Construction of recombinant adenovirus with Egr-1 promoter and Smad7 cDNA and study of the Egr-1 promoter's biological activity

International Nuclear Information System (INIS)

Cai Xuwei; Fu Xiaolong; Yang Jian; Song Houyan

2005-01-01

Objective: To construct a recombinant replication-defective adenovirus containing Egr-1 promoter and Smad7 cDNA, then to evaluate the biological activity of Egr-1 promoter. Methods: Based on Adeno- X TM expression system, CMV promoter of the pShuttle vector was replaced by Egr-1 promoter, and the Smad7 cDNA was subcloned into the MCS(multiple cloning site) of pShuttle. The recombinant pShuttle was then sub-cloned into the Adeno-X TM genome, which was transformed into E. coli to get recombinant Adeno-X TM plasmid DNA. The recombinant adenovirus was packaged and amplified in the transfected HEK293 cells before it was purified and tested for viral titer. The fibroblasts (3T6 cells) infected by the recombinant adenovirus were irradiated , and the activity of Egr-1 promoter was quantitively determined by the amount of Smad7 protein expressed in the 3T6 cells using Western blot. Results: Identified by restriction endonuclease analysis and PCR, the recombinant adenovirus containing Egr-1 promoter and Smad7 cDNA was constructed successfully, with a viral titer of 1.0 x 10 11 TCID 50 /ml. The expressed amount of Smad7 protein varied at different dose levels and different time points post-irradiation in the 3T6 cells infected with the recombinant adenovirus. The amount of Smad7 protein increased along with the rising of the irradiation dose, and remained at a high expression level from 8 Gy to 15 Gy. The amount of Smad7 protein started to increase at 2 hours post-irradiation, and maintained a relatively high level for the next 5 hours before it descended, which was not observed in the control 3T6 cells. Conclusions: With the aid of Adeno-X TM expression system and molecular cloning techniques, construction of recombinant adenovirus could be quick and efficient. The recombined Egr-1 promoter has the activity of regulating the expression of downstream Smad7 cDNA. The increase in Smad7 expression under control of Egr-1 promoter induced by ionizing radiation is time- and dose

MUC1-C Oncoprotein Integrates a Program of EMT, Epigenetic Reprogramming and Immune Evasion in Human Carcinomas.

Science.gov (United States)

Rajabi, Hasan; Kufe, Donald

2017-08-01

The MUC1 gene evolved in mammalian species to provide protection of epithelia. The transmembrane MUC1 C-terminal subunit (MUC1-C) signals stress to the interior of the epithelial cell and, when overexpressed as in most carcinomas, functions as an oncoprotein. MUC1-C induces the epithelial-mesenchymal transition (EMT) by activating the inflammatory NF-κB p65 pathway and, in turn, the EMT-transcriptional repressor ZEB1. Emerging evidence has indicated that MUC1-C drives a program integrating the induction of EMT with activation of stem cell traits, epigenetic reprogramming and immune evasion. This mini-review focuses on the potential importance of this MUC1-C program in cancer progression. Copyright © 2017 Elsevier B.V. All rights reserved.

Constructing and detecting a cDNA library for mites.

Science.gov (United States)

Hu, Li; Zhao, YaE; Cheng, Juan; Yang, YuanJun; Li, Chen; Lu, ZhaoHui

2015-10-01

RNA extraction and construction of complementary DNA (cDNA) library for mites have been quite challenging due to difficulties in acquiring tiny living mites and breaking their hard chitin. The present study is to explore a better method to construct cDNA library for mites that will lay the foundation on transcriptome and molecular pathogenesis research. We selected Psoroptes cuniculi as an experimental subject and took the following steps to construct and verify cDNA library. First, we combined liquid nitrogen grinding with TRIzol for total RNA extraction. Then, switching mechanism at 5' end of the RNA transcript (SMART) technique was used to construct full-length cDNA library. To evaluate the quality of cDNA library, the library titer and recombination rate were calculated. The reliability of cDNA library was detected by sequencing and analyzing positive clones and genes amplified by specific primers. The results showed that the RNA concentration was 836 ng/μl and the absorbance ratio at 260/280 nm was 1.82. The library titer was 5.31 × 10(5) plaque-forming unit (PFU)/ml and the recombination rate was 98.21%, indicating that the library was of good quality. In the 33 expressed sequence tags (ESTs) of P. cuniculi, two clones of 1656 and 1658 bp were almost identical with only three variable sites detected, which had an identity of 99.63% with that of Psoroptes ovis, indicating that the cDNA library was reliable. Further detection by specific primers demonstrated that the 553-bp Pso c II gene sequences of P. cuniculi had an identity of 98.56% with those of P. ovis, confirming that the cDNA library was not only reliable but also feasible.

Optimization of the annual construction program solutions

Directory of Open Access Journals (Sweden)

Oleinik Pavel

2017-01-01

Full Text Available The article considers potentially possible optimization solutions in scheduling while forming the annual production programs of the construction complex organizations. The optimization instrument is represented as a two-component system. As a fundamentally new approach in the first block of the annual program solutions, the authors propose to use a scientifically grounded methodology for determining the scope of work permissible for the transfer to a subcontractor without risk of General Contractor’s management control losing over the construction site. For this purpose, a special indicator is introduced that characterizes the activity of the general construction organization - the coefficient of construction production management. In the second block, the principal methods for the formation of calendar plans for the fulfillment of the critical work effort by the leading stream are proposed, depending on the intensity characteristic.

Practical C++ Programming

CERN Document Server

Oualline, Steve

2003-01-01

C++ is a powerful, highly flexible, and adaptable programming language that allows software engineers to organize and process information quickly and effectively. But this high-level language is relatively difficult to master, even if you already know the C programming language. The 2nd edition of Practical C++ Programming is a complete introduction to the C++ language for programmers who are learning C++. Reflecting the latest changes to the C++ standard, this 2nd edition takes a useful down-to-earth approach, placing a strong emphasis on how to design clean, elegant code. In short, to-th

RECOMMENDED FOUNDATION FILL MATERIALS CONSTRUCTION STANDARD OF THE FLORIDA RADON RESEARCH PROGRAM

Science.gov (United States)

The report summarizes the technical basis for a recommended foundation fill materials standard for new construction houses in Florida. he radon-control construction standard was developed by the Florida Radon Research Program (FRRP). ill material standards are formulated for: (1)...

Construction safety program for the National Ignition Facility

Energy Technology Data Exchange (ETDEWEB)

Cerruti, S.J.

1997-06-26

The Construction Safety Program (CSP) for NIF sets forth the responsibilities, guidelines, rules, policies and regulations for all workers involved in the construction, special equipment installation, acceptance testing, and initial activation and operation of NIF at LLNL during the construction period of NIF.

Construction safety program for the National Ignition Facility

International Nuclear Information System (INIS)

Cerruti, S.J.

1997-01-01

The Construction Safety Program (CSP) for NIF sets forth the responsibilities, guidelines, rules, policies and regulations for all workers involved in the construction, special equipment installation, acceptance testing, and initial activation and operation of NIF at LLNL during the construction period of NIF

Construction and Verification of PLC LD-programs by LTL-specification

Directory of Open Access Journals (Sweden)

E. V. Kuzmin

2013-01-01

Full Text Available An approach to construction and verification of PLC LD-programs for discrete problems is proposed. For the specification of the program behavior, we use the linear-time temporal logic LTL. Programming is carried out in the LD-language (Ladder Diagram according to an LTL-specification. The correctness analysis of an LTL-specification is carried out by the symbolic model checking tool Cadence SMV. A new approach to programming and verification of PLC LD-programs is shown by an example. For a discrete problem, we give a LD-program, its LTL-specification and an SMV-model. The purpose of the article is to describe an approach to programming PLC, which would provide a possibility of LD-program correctness analysis by the model checking method. Under the proposed approach, the change of the value of each program variable is described by a pair of LTL-formulas. The first LTL-formula describes situations which increase the value of the corresponding variable, the second LTL-formula specifies conditions leading to a decrease of the variable value. The LTL-formulas (used for speci- fication of the corresponding variable behavior are constructive in the sense that they construct the PLC-program (LD-program, which satisfies temporal properties expressed by these formulas. Thus, the programming of PLC is reduced to the construction of LTLspecification of the behavior of each program variable. In addition, an SMV-model of a PLC LD-program is constructed according to LTL-specification. Then, the SMV-model is analysed by the symbolic model checking tool Cadence SMV.

The technical feasibility of uranium enrichment for nuclear bomb construction at the parallel nuclear program plant

International Nuclear Information System (INIS)

Rosa, L.P.

1990-01-01

It is discussed the hole of the Parallel Nuclear Program is Brazil and the feasibility of uranium enrichment for nuclear bomb construction. This program involves two research centers, one belonging to the brazilian navy and another to the aeronautics. Some other brazilian institutes like CTA, IPEN, COPESP and CETEX and also taking part in the program. (A.C.A.S.)

On Construction and Verification of PLC-Programs

Directory of Open Access Journals (Sweden)

E. V. Kuzmin

2012-01-01

Full Text Available We review some methods and approaches to programming discrete problems for Programmable Logic Controllers on the example of constructing PLC-programs for controling a code lock. For these approaches we evaluate the usability of the model checking method for the analysis of program correctness with respect to the automatic verification tool Cadence SMV. Some possible PLC-program vulnerabilities arising at a number approaches to programming of PLC are revealed.

[Construction of fetal mesenchymal stem cell cDNA subtractive library].

Science.gov (United States)

Yang, Li; Wang, Dong-Mei; Li, Liang; Bai, Ci-Xian; Cao, Hua; Li, Ting-Yu; Pei, Xue-Tao

2002-04-01

To identify differentially expressed genes between fetal mesenchymal stem cell (MSC) and adult MSC, especially specified genes expressed in fetal MSC, a cDNA subtractive library of fetal MSC was constructed using suppression subtractive hybridization (SSH) technique. At first, total RNA was isolated from fetal and adult MSC. Using SMART PCR synthesis method, single-strand and double-strand cDNAs were synthesized. After Rsa I digestion, fetal MSC cDNAs were divided into two groups and ligated to adaptor 1 and adaptor 2 respectively. Results showed that the amplified library contains 890 clones. Analysis of 890 clones with PCR demonstrated that 768 clones were positive. The positive rate is 86.3%. The size of inserted fragments in these positive clones was between 0.2 - 1 kb, with an average of 400 - 600 bp. SSH is a convenient and effective method for screening differentially expressed genes. The constructed cDNA subtractive library of fetal MSC cDNA lays solid foundation for screening and cloning new and specific function related genes of fetal MSC.

Perspex machine: V. Compilation of C programs

Science.gov (United States)

Spanner, Matthew P.; Anderson, James A. D. W.

2006-01-01

The perspex machine arose from the unification of the Turing machine with projective geometry. The original, constructive proof used four special, perspective transformations to implement the Turing machine in projective geometry. These four transformations are now generalised and applied in a compiler, implemented in Pop11, that converts a subset of the C programming language into perspexes. This is interesting both from a geometrical and a computational point of view. Geometrically, it is interesting that program source can be converted automatically to a sequence of perspective transformations and conditional jumps, though we find that the product of homogeneous transformations with normalisation can be non-associative. Computationally, it is interesting that program source can be compiled for a Reduced Instruction Set Computer (RISC), the perspex machine, that is a Single Instruction, Zero Exception (SIZE) computer.

Practical C programming

CERN Document Server

Oualline, Steve

1997-01-01

There are lots of introductory C books, but this is the first one that has the no-nonsense, practical approach that has made Nutshell Handbooks® famous. C programming is more than just getting the syntax right. Style and debugging also play a tremendous part in creating programs that run well and are easy to maintain. This book teaches you not only the mechanics of programming, but also describes how to create programs that are easy to read, debug, and update. Practical rules are stressed. For example, there are fifteen precedence rules in C (&& comes before || comes before ?:). The practi

Identifying the Critical Factors Affecting Safety Program Performance for Construction Projects within Pakistan Construction Industry

Directory of Open Access Journals (Sweden)

Zubair Ahmed Memon

2013-04-01

Full Text Available Many studies have shown that the construction industry one of the most hazardous industries with its high rates of fatalities and injuries and high financial losses incurred through work related accident. To reduce or overcome the safety issues on construction sites, different safety programs are introduced by construction firms. A questionnaire survey study was conducted to highlight the influence of the Construction Safety Factors on safety program implementation. The input from the questionnaire survey was analyzed by using AIM (Average Index Method and rank correlation test was conducted between different groups of respondents to measure the association between different groups of respondent. The finding of this study highlighted that management support is the critical factor for implementing the safety program on projects. From statistical test, it is concluded that all respondent groups were strongly in the favor of management support factor as CSF (Critical Success Factor. The findings of this study were validated on selected case studies. Results of the case studies will help to know the effect of the factors on implementing safety programs during the execution stage.

Measurement plan and observational construction program on drift excavation at the Horonobe Underground Research Laboratory project

International Nuclear Information System (INIS)

Yamasaki, Masanao; Yamaguchi, Takehiro; Funaki, Hironori; Fujikawa, Daisuke; Tsusaka, Kimikazu

2008-09-01

The Horonobe URL Project is being pursued by the Japan Atomic Energy Agency (JAEA) to enhance the reliability of relevant disposal technologies through investigations of the deep geological environment within the host sedimentary formations at Horonobe, northern Hokkaido. The project consists of two major research areas, 'Geoscientific Research' and 'R and D' on Geological Disposal', and proceeds in three overlapping phases, 'Phase I: Surface-based investigation', 'Phase II: Construction' and 'Phase III: Operation', over a period of 20 years. On the Horonobe URL Project, 'Phase 1' was finished in 2005FY and construction of the underground facility was started since then. Now, 'Phase 2' (investigations during construction of the underground facilities) is on-going. On the 'Development of engineering techniques for use in the deep underground environment' in Phase 1, based on the various types of data acquired on investigations from the surface, the design of underground facility in advance was planned. At the inception of the Phase II investigations, an investigation report titled 'Measurement Plan and Observational Construction Program on Shaft Excavation at the Horonobe URL Project' (hereinafter referred to as 'Observational Construction Program') was published. The Observational Construction Program summarizes followings from the Phase I investigations: measurements for safety/reasonable construction, measurements for R and D on enhancement of shaft design/construction technology, and measurements for verification of the deep geological environment model estimated before shaft excavation, and it is on-going. This report summarizes the measurement plan during construction of drifts based on the design in advance and the observational construction program for feedback measurements data into design and construction on subsequent steps. This report also describes about design and construction management program of underground facility and R and D program on

Mastering C pointers tools for programming power

CERN Document Server

Traister, Robert J

2014-01-01

If you don't fully understand C pointers and how they are used, you're not getting the most out of C programming. This book features complete coverage on using and controlling C language pointers to make C applications more powerful and expressive. This new edition is completely updated and revised to reflect the changes that have been brought about with the full adoption of ANSI C. All discussions and program examples have been updated, and reading materials necessary for any modern ANSI C programmer have also been added.Includes one 3 1/2"" disk containing all of the working programs and m

Simultaneous test construction by zero-one programming

NARCIS (Netherlands)

Boekkooi-Timminga, Ellen

1986-01-01

A method is described for simultaneous test construction using the Operations Research technique zero-one programming. The model for zero-one programming consists of two parts. The first contains the objective function that describes the aspect to be optimized. The second part contains the

43 CFR 12.830 - Buy American Act-Construction materials.

Science.gov (United States)

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Buy American Act-Construction materials... Assistance Programs Buy American Act-Construction Materials § 12.830 Buy American Act—Construction materials...—Construction Materials (a) The Buy American Act (41 U.S.C. 10) provides that the Government give preference to...

Construction safety management guide for use with DOE Order 440.1

International Nuclear Information System (INIS)

1997-01-01

DOE Order (DOE O) 440.1, Worker Protection Management for DOE Federal and Contractor Employees, establishes the framework for an effective worker protection program to reduce or eliminate accidental losses, injuries, and illnesses by providing workers with places of employment free of recognized hazards. In addition to prescribing program requirements applicable to all activities performed by DOE and its contractors, DOE O 440.1 provides specific requirements applicable only to construction activities. The intent of these construction-specific requirements is to compel the proactive management of construction safety on a project-by-project basis and, to the greatest extent possible, integrate the management of safety and health, both in terms of project personnel and management methodologies, with the management of the other primary elements of construction project performance: quality, cost and schedule

A worksite prevention program for construction workers: design of a randomized controlled trial.

Science.gov (United States)

Oude Hengel, Karen M; Joling, Catelijne I; Proper, Karin I; Blatter, Birgitte M; Bongers, Paulien M

2010-06-14

A worksite prevention program was developed to promote the work ability of construction workers and thereby prolong a healthy working life. The objective of this paper is to present the design of a randomized controlled trial evaluating the effectiveness of that intervention program compared with usual care for construction workers. The study is designed as a randomized controlled trial with a follow-up of one year. Employees eligible for this study are construction workers performing actual construction work. The worksite intervention will be compared with usual care. This intervention was developed by using the Intervention Mapping approach and consists of the following components: (1) two individual training sessions of a physical therapist to lower the physical workload, (2) a Rest-Break tool to improve the balance between work and recovery, and (3) two empowerment training sessions to increase the influence of the construction workers at the worksite. Outcome measures are assessed at baseline, 3, 6, and 12 months. The primary outcome measures of this study are work ability and health-related quality of life. Secondary outcome measures include need for recovery, musculoskeletal complaints, work engagement and self efficacy. Cost-effectiveness will be evaluated from the company perspective. Moreover, a process evaluation will be conducted. The feasibility of the intervention and the study has been enhanced by creating an intervention program that explicitly appeals to construction workers and will not interfere too much with the ongoing construction. The feasibility and effectiveness of this worksite prevention program will be investigated by means of an effect- and a process evaluation. If proven effective, this worksite prevention program can be implemented on a larger scale within the construction industry. NTR1278.

C++ how to program

CERN Document Server

Deitel, Paul J

2014-01-01

This best-selling comprehensive text is aimed at readers with little or no programming experience. It teaches programming by presenting the concepts in the context of full working programs and takes an early-objects approach. The authors emphasize achieving program clarity through structured and object-oriented programming, software reuse and component-oriented software construction. The Ninth Edition encourages students to connect computers to the community, using the Internet to solve problems and make a difference in our world. All content has been carefully fine-tuned in response to a team of distinguished academic and industry reviewers.

Efficient C/C++ programming smaller, faster, better

CERN Document Server

Heller, Steve

1994-01-01

Efficient C/C++ Programming describes a practical, real-world approach to efficient C/C++ programming. Topics covered range from how to save storage using a restricted character set and how to speed up access to records by employing hash coding and caching. A selective mailing list system is used to illustrate rapid access to and rearrangement of information selected by criteria specified at runtime.Comprised of eight chapters, this book begins by discussing factors to consider when deciding whether a program needs optimization. In the next chapter, a supermarket price lookup system is used to

A Solid Foundation: Key Capacities of Construction Pre-Apprenticeship Programs

Science.gov (United States)

Helmer, Matt; Blair, Amy; Gerber, Allison

2012-01-01

This publication shares research from site visits conducted to construction pre-apprenticeship programs in Baltimore, Hartford, Milwaukee and Portland (OR). Findings from the site visits, which included interviews and focus groups with pre-apprenticeship program staff, public officials, philanthropic leaders, construction industry leaders and…

Construction of a T7 Human Lung Cancer cDNA Library

Directory of Open Access Journals (Sweden)

Wentao YUE

2008-10-01

Full Text Available Background and objective Currently, only a limited numbers of tumor markers for non small lung cancer (NSCLC diagnosis, new biomarker, such as serum autoantibody may improve the early detection of lung cancer. Our objective is construction human lung squamous carcinoma and adenocarcinoma T7 phage display cDNA library from the tissues of NSCLC patients. Methods mRNA was isolated from a pool of total RNA extract from NSCLC tissues obtained from 5 adenocarcinomas and 5 squamous carcinomas, and then mRNA was reverse transcribed into double stranded cDNA. After digestion, the cDNA was inserted into T7Select 10-3 vector. The phage display cDNA library was constructed by package reaction in vitro and plate proliferation. Plaque assay and PCR were used to evaluate the library.Results Two T7 phage display cDNA library were established. Plaque assay show the titer of lung squamas carcinoma library was 1.8×106 pfu, and the adenocarcinoma library was 5×106 pfu. The phage titer of the amplified library were 3.2×1010 pfu/mL and 2.5×1010 pfu/mL. PCR amplification of random plaque show insert ratio were 100% (24/24 in adenocarcinoma library and 95.8% in human lung squamas carcinoma library (23/24. Insert range from 300 bp to 1 500 bp. Conclusion Two phage display cDNA library from NSCLC were constructed.

Impact of Disease Management Programs on HbA1c Values in Type 2 Diabetes Patients in Germany.

Science.gov (United States)

Kostev, Karel; Rockel, Timo; Jacob, Louis

2017-01-01

The aim was to analyze the impact of disease management programs on HbA1c values in type 2 diabetes mellitus (T2DM) patients in Germany. This study included 9017 patients followed in disease management programs (DMPs) who started an antihyperglycemic treatment upon inclusion in a DMP. Standard care (SC) patients were included after individual matching (1:1) to DMP cases based on age, gender, physician (diabetologist versus nondiabetologist care), HbA1c values at baseline, and index year. The main outcome was the share of patients with HbA1c HbA1c level as a dependent variable and the potential predictor (DMP versus SC). The mean age was 64.3 years and 54.7% of the patients were men. The mean HbA1c level at baseline was equal to 8.7%. In diabetologist practices, 64.7% of DMP patients and 55.1% of SC patients had HbA1c levels HbA1c levels HbA1c levels HbA1c levels HbA1c levels lower than 7.5% or 6.5% after 6 months of therapy in both diabetologist and general care practices. The present study indicates that the enrollment of T2DM patients in DMPs has a positive impact on HbA1c values in Germany.

A worksite prevention program for construction workers: design of a randomized controlled trial

Directory of Open Access Journals (Sweden)

Proper Karin I

2010-06-01

Full Text Available Abstract Background A worksite prevention program was developed to promote the work ability of construction workers and thereby prolong a healthy working life. The objective of this paper is to present the design of a randomized controlled trial evaluating the effectiveness of that intervention program compared with usual care for construction workers. Methods The study is designed as a randomized controlled trial with a follow-up of one year. Employees eligible for this study are construction workers performing actual construction work. The worksite intervention will be compared with usual care. This intervention was developed by using the Intervention Mapping approach and consists of the following components: (1 two individual training sessions of a physical therapist to lower the physical workload, (2 a Rest-Break tool to improve the balance between work and recovery, and (3 two empowerment training sessions to increase the influence of the construction workers at the worksite. Outcome measures are assessed at baseline, 3, 6, and 12 months. The primary outcome measures of this study are work ability and health-related quality of life. Secondary outcome measures include need for recovery, musculoskeletal complaints, work engagement and self efficacy. Cost-effectiveness will be evaluated from the company perspective. Moreover, a process evaluation will be conducted. Discussion The feasibility of the intervention and the study has been enhanced by creating an intervention program that explicitly appeals to construction workers and will not interfere too much with the ongoing construction. The feasibility and effectiveness of this worksite prevention program will be investigated by means of an effect- and a process evaluation. If proven effective, this worksite prevention program can be implemented on a larger scale within the construction industry. Trial Registration NTR1278

Algorithms and programs for consequence diagram and fault tree construction

International Nuclear Information System (INIS)

Hollo, E.; Taylor, J.R.

1976-12-01

A presentation of algorithms and programs for consequence diagram and sequential fault tree construction that are intended for reliability and disturbance analysis of large systems. The system to be analyzed must be given as a block diagram formed by mini fault trees of individual system components. The programs were written in LISP programming language and run on a PDP8 computer with 8k words of storage. A description is given of the methods used and of the program construction and working. (author)

Programming While Construction of Engineering 3D Models of Complex Geometry

Science.gov (United States)

Kheyfets, A. L.

2017-11-01

The capabilities of geometrically accurate computational 3D models construction with the use of programming are presented. The construction of models of an architectural arch and a glo-boid worm gear is considered as an example. The models are designed in the AutoCAD pack-age. Three programs of construction are given. The first program is for designing a multi-section architectural arch. The control of the arch’s geometry by impacting its main parameters is shown. The second program is for designing and studying the working surface of a globoid gear’s worm. The article shows how to make the animation for this surface’s formation. The third program is for formation of a worm gear cavity surface. The cavity formation dynamics is studied. The programs are written in the AutoLisp programming language. The program texts are provided.

Gap Analysis Approach for Construction Safety Program Improvement

Directory of Open Access Journals (Sweden)

Thanet Aksorn

2007-06-01

Full Text Available To improve construction site safety, emphasis has been placed on the implementation of safety programs. In order to successfully gain from safety programs, factors that affect their improvement need to be studied. Sixteen critical success factors of safety programs were identified from safety literature, and these were validated by safety experts. This study was undertaken by surveying 70 respondents from medium- and large-scale construction projects. It explored the importance and the actual status of critical success factors (CSFs. Gap analysis was used to examine the differences between the importance of these CSFs and their actual status. This study found that the most critical problems characterized by the largest gaps were management support, appropriate supervision, sufficient resource allocation, teamwork, and effective enforcement. Raising these priority factors to satisfactory levels would lead to successful safety programs, thereby minimizing accidents.

Dicty_cDB: Contig-U05935-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available MOF-029C10, gen... 42 5.6 1 ( CT497775 ) A BAC library has been constructed from cultivar ... 42 5.6 1 ( CC2...... 42 5.6 1 ( CK278923 ) EST725001 potato abiotic stress cDNA library Sola... 42... 5.6 1 ( CK276546 ) EST722624 potato abiotic stress cDNA library Sola... 42 5.6 1 ( CK256717 ) EST740354 potato callus cDNA library...14 ) GR_Sa0007H24.b1 Gossypium raimondii WGS library G... 42 5.6 1 ( DU663768 ) OG_ABa0072K07.r OG_ABa Oryza granulata genomic...) Macropus eugenii clone ME_KBa-598C23, WORKING DRA... 42 5.6 1 ( AY714860 ) Unculture

Programming principles and practice using C++

CERN Document Server

Stroustrup, Bjarne

2014-01-01

An Introduction to Programming by the Inventor of C++ Preparation for Programming in the Real World The book assumes that you aim eventually to write non-trivial programs, whether for work in software development or in some other technical field. Focus on Fundamental Concepts and Techniques The book explains fundamental concepts and techniques in greater depth than traditional introductions. This approach will give you a solid foundation for writing useful, correct, maintainable, and efficient code. Programming with Today's C++ (C++11 and C++14) The book is an introduction to programming in general, including object-oriented programming and generic programming. It is also a solid introduction to the C++ programming language, one of the most widely used languages for real-world software. The book presents modern C++ programming techniques from the start, introducing the C++ standard library and C++11 and C++14 features to simplify programming tasks. For Beginners-And Anyone Who Wants to Learn Something New The...

M2-F1 in flight being towed by a C-47

Science.gov (United States)

1964-01-01

The M2-F1 Lifting Body is seen here being towed behind a C-47 at the Flight Research Center (later redesignated the Dryden Flight Research Center), Edwards, California. In this rear view, the M2-F1 is flying above and to one side of the C-47. This was done to avoid wake turbulence from the towplane. Lacking wings, the M2-F1 used an unusual configuration for its control surfaces. It had two rudders on the fins, two elevons (called 'elephant ears') mounted on the outsides of the fins, and two body flaps on the upper rear fuselage. The wingless, lifting body aircraft design was initially concieved as a means of landing an aircraft horizontally after atmospheric reentry. The absence of wings would make the extreme heat of re-entry less damaging to the vehicle. In 1962, Dryden management approved a program to build a lightweight, unpowered lifting body as a prototype to flight test the wingless concept. It would look like a 'flying bathtub,' and was designated the M2-F1, the 'M' referring to 'manned' and 'F' referring to 'flight' version. It featured a plywood shell placed over a tubular steel frame crafted at Dryden. Construction was completed in 1963. The first flight tests of the M2-F1 were over Rogers Dry Lake at the end of a tow rope attached to a hopped-up Pontiac convertible driven at speeds up to about 120 mph. These initial tests produced enough flight data about the M2-F1 to proceed with flights behind the C-47 tow plane at greater altitudes. The C-47 took the craft to an altitude of 12,000 where free flights back to Rogers Dry Lake began. Pilot for the first series of flights of the M2-F1 was NASA research pilot Milt Thompson. Typical glide flights with the M2-F1 lasted about two minutes and reached speeds of 110 to l20 mph. More than 400 ground tows and 77 aircraft tow flights were carried out with the M2-F1. The success of Dryden's M2-F1 program led to NASA's development and construction of two heavyweight lifting bodies based on studies at NASA's Ames and

Radical C-H functionalization to construct heterocyclic compounds.

Science.gov (United States)

Yu, Jin-Tao; Pan, Changduo

2016-02-07

Heterocyclic compounds are widely present in natural products, pharmaceuticals and bioactive molecules. Thus, organic and pharmaceutical chemists have been making extensive efforts to construct those heterocyclic frameworks through developing versatile and efficient synthetic strategies. The direct C-H functionalization via the radical pathway has emerged as a promising and dramatic approach towards heterocycles with high atom- and step-economy. Heterocyclic compounds such as coumarins, furans, benzofurans, xanthones, benzothiazoles, indoles, indolines, oxindoles, quinolines, isoquinolines, quinoxaline, and phenanthridines have been successfully synthesized by C-H functionalization through the radical pathway. In this review, recent advances on radical C-H functionalization to construct heterocyclic compounds are highlighted with discussions.

Construction Improvement for the Korean Nuclear Program

International Nuclear Information System (INIS)

Yang, T. E.

1992-01-01

Construction of the nine Nuclear plants requires an enormous financial investment. The decision to build a nuclear unit is based on both economic and resource requirements. Korea has few natural resources to use for power generation so the use of diversified fuel sources is a part of the planning process. Nuclear has historically had economic advantages over the fossil fueled plant, however, this advantage has been reduced. This is mainly due to increasing decommissioning and waste disposal costs plus the financial outlays associated with gaining public acceptance of new nuclear units. One of the principal means to recover the economic advantage of a nuclear plant is to shorten the time needed for construction. Every extra day of construction costs large sums of money in interest and escalation expenses alone. The challenge is to shorten the construction period to the minimum feasible time and thereby reduce the financing costs. The methods that have to be employed to achieve this goal require the total commitment from the management of all entities involved in the program. Through the application of advanced management and construction techniques a new era in the construction of nuclear plants in Korea will occur. This will include changes to the methods used for managing, planning, licensing, designing and constructing the new plants. The ability to meet the aggressive plan for the construction of new nuclear power plants in Korea rests in the hands of the managers of all the parties involved. These men set all the rules by which the new plants will be constructed. It is their responsibility to tackle the current problems and develop the solutions to enable the plan to be realized. The changes suggested within this paper are major, but the potential benefits will allow the Korean Nuclear Industry to advance into the twenty first Century as a leader. The number of fully trained specialists needed to make this happen will not appear overnight. They will have to be

Beginning C# Object-Oriented Programming

CERN Document Server

Clark, Dan

2011-01-01

Beginning C# Object-Oriented Programming brings you into the modern world of development as you master the fundamentals of programming with C# and learn to develop efficient, reusable, elegant code through the object-oriented programming (OOP) methodology. Take your skills out of the 20th century and into this one with Dan Clark's accessible, quick-paced guide to C# and object-oriented programming, completely updated for .NET 4.0 and C# 4.0. As you develop techniques and best practices for coding in C#, one of the world's most popular contemporary languages, you'll experience modeling a "real

Utility residential new construction programs: Going beyond the code. A report from the Database on Energy Efficiency Programs (DEEP) Project

Energy Technology Data Exchange (ETDEWEB)

Vine, E.

1995-08-01

Based on an evaluation of 10 residential new construction programs, primarily sponsored by investor-owned utilities in the United States, we find that many of these programs are in dire straits and are in danger of being discontinued because current inclusion of only direct program effects leads to the conclusion that they are not cost-effective. We believe that the cost-effectiveness of residential new construction programs can be improved by: (1) promoting technologies and advanced building design practices that significantly exceed state and federal standards; (2) reducing program marketing costs and developing more effective marketing strategies; (3) recognizing the role of these programs in increasing compliance with existing state building codes; and (4) allowing utilities to obtain an ``energy-savings credit`` from utility regulators for program spillover (market transformation) impacts. Utilities can also leverage their resources in seizing these opportunities by forming strong and trusting partnerships with the building community and with local and state government.

Synthesis of the C1-C28 Portion of Spongistatin 1 (Altohyrtin A).

Science.gov (United States)

Claffey, Michelle M.; Hayes, Christopher J.; Heathcock, Clayton H.

1999-10-29

A synthetic approach was developed to the C1-C28 subunit of spongistatin 1 (altohyrtin A, 65). The key step was the coupling of the AB and CD spiroketal moieties via an anti-aldol reaction of aldehyde 62 and ethyl ketone 57. The development of a method for the construction of the AB spiroketal fragment is described and included the desymmetrization of C(2)-symmetric diketone 10 and the differentiation of the two primary alcohols of 16. Further elaboration of this advanced intermediate to the desired aldehyde 62 included an Evans' syn-aldol reaction and Tebbe olefination. The synthesis of the CD spiroketal fragment 56 involved the ketalization of a triol-dione, generated in situ by deprotection of 45, to provide a favorable ratio (6-7:1) of spiroketal isomers 46 and 47, respectively. The overall protecting group strategy, involving many selective manipulations of silyl protecting groups, was successfully developed to provide the desired C1-C28 subunit of spongistatin 1 (altohyrtin A) (65).

25 CFR Appendix C to Subpart C - Relative Need Distribution Factor

Science.gov (United States)

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Relative Need Distribution Factor C Appendix C to Subpart...—Relative Need Distribution Factor The Relative Need Distribution Factor (RNDF) is a mathematical formula for distributing the IRR Program construction funds using the following three factors: Cost to...

Process Evaluation of a Toolbox-training Program for Construction Foremen in Denmark

DEFF Research Database (Denmark)

Jeschke, Katharina Christiane; Kines, Pete; Rasmussen, Liselotte

2017-01-01

for the majority of the foremen, who experienced positive changes in their daily work methods and interactions with their crews, colleagues, leaders, customers and other construction professions. The program is a unique contribution to leadership training in the construction industry, and can potentially......Daily dialogue between leaders and workers on traditional construction sites is primarily focused on production, quality and time issues, and rarely involves occupational safety and health (OSH) issues. A leadership training program entitled 'Toolbox-training' was developed to improve construction...

7 CFR Appendix C to Part 225 - Child Nutrition (CN) Labeling Program

Science.gov (United States)

2010-01-01

...). EC17SE91.006 (c) The CN label statement includes the following: (1) The product identification number... 7 Agriculture 4 2010-01-01 2010-01-01 false Child Nutrition (CN) Labeling Program C Appendix C to... Appendix C to Part 225—Child Nutrition (CN) Labeling Program 1. The Child Nutrition (CN) Labeling Program...

Development of a safety communication and recognition program for construction.

Science.gov (United States)

Sparer, Emily H; Herrick, Robert F; Dennerlein, Jack T

2015-05-01

Leading-indicator-based (e.g., hazard recognition) incentive programs provide an alternative to controversial lagging-indicator-based (e.g., injury rates) programs. We designed a leading-indicator-based safety communication and recognition program that incentivized safe working conditions. The program was piloted for two months on a commercial construction worksite and then redesigned using qualitative interview and focus group data from management and workers. We then ran the redesigned program for six months on the same worksite. Foremen received detailed weekly feedback from safety inspections, and posters displayed worksite and subcontractor safety scores. In the final program design, the whole site, not individual subcontractors, was the unit of analysis and recognition. This received high levels of acceptance from workers, who noted increased levels of site unity and team-building. This pilot program showed that construction workers value solidarity with others on site, demonstrating the importance of health and safety programs that engage all workers through a reliable and consistent communication infrastructure. © The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Loyalty Program in the Pharmacy. Case of Construction and Implementation

Directory of Open Access Journals (Sweden)

Agnieszka Woś

2008-03-01

Full Text Available This paper presents the process of construction the loyalty programs between pharmaceutical market that is shaped warehouse, pharmacy and patient. The examples of this loyalty programs in this article has confirm the opinion about programs as efficiency in the pharmaceutical environment in Poland.

Name management in the construction of large programs. [Modular decomposition, programmed in PL/I for IBM 360/65

Energy Technology Data Exchange (ETDEWEB)

Carr, P.A.; Keller, R.F.; Wright, C.T. Jr.

1976-08-01

There has been much recent work on the problem of constructing large programs. One aspect of this problem that has been somewhat ignored is the management of names during the program construction process. A framework emphasizing this aspect of the problem is presented. Linguistic constructs for the manipulation of names between independently written pieces of text are defined. An implementation model defining the effect of these constructs on the naming structure of the resulting language is presented. The implementation model is demonstrated in terms of an example to illustrate the usefulness of the framework.

48 CFR 252.225-7044 - Balance of Payments Program-Construction Material.

Science.gov (United States)

2010-10-01

... Program-Construction Material. 252.225-7044 Section 252.225-7044 Federal Acquisition Regulations System...—Construction Material. As prescribed in 225.7503(a), use the following clause: Balance of Payments Program—Construction Material (JAN 2009) (a) Definitions. As used in this clause— Commercially available off-the-shelf...

LOADING SIMULATION PROGRAM C

Data.gov (United States)

U.S. Environmental Protection Agency — LSPC is the Loading Simulation Program in C++, a watershed modeling system that includes streamlined Hydrologic Simulation Program Fortran (HSPF) algorithms for...

Functional Programming in C# Classic Programming Techniques for Modern Projects

CERN Document Server

Sturm, Oliver

2011-01-01

Take advantage of the growing trend in functional programming. C# is the number-one language used by .NET developers and one of the most popular programming languages in the world. It has many built-in functional programming features, but most are complex and little understood. With the shift to functional programming increasing at a rapid pace, you need to know how to leverage your existing skills to take advantage of this trend. Functional Programming in C# leads you along a path that begins with the historic value of functional ideas. Inside, C# MVP and functional programming expert Oli

LOADING SIMULATION PROGRAM C

Science.gov (United States)

LSPC is the Loading Simulation Program in C++, a watershed modeling system that includes streamlined Hydrologic Simulation Program Fortran (HSPF) algorithms for simulating hydrology, sediment, and general water quality

Object-oriented graphics programming in C++

CERN Document Server

Stevens, Roger T

2014-01-01

Object-Oriented Graphics Programming in C++ provides programmers with the information needed to produce realistic pictures on a PC monitor screen.The book is comprised of 20 chapters that discuss the aspects of graphics programming in C++. The book starts with a short introduction discussing the purpose of the book. It also includes the basic concepts of programming in C++ and the basic hardware requirement. Subsequent chapters cover related topics in C++ programming such as the various display modes; displaying TGA files, and the vector class. The text also tackles subjects on the processing

7 CFR Appendix C to Part 226 - Child Nutrition (CN) Labeling Program

Science.gov (United States)

2010-01-01

...). EC17SE91.009 (c) The CN label statement includes the following: (1) The product identification number... 7 Agriculture 4 2010-01-01 2010-01-01 false Child Nutrition (CN) Labeling Program C Appendix C to.... C Appendix C to Part 226—Child Nutrition (CN) Labeling Program 1. The Child Nutrition (CN) Labeling...

Dicty_cDB: Contig-U02520-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available ) KBrH001K21F KBrH, Brassica rapa HindIII BAC libra... 46 3.3 1 ( CT538104 ) A BAC library has been constructed from culti...1 ( DR026249 ) Osmo00116 F. cylindrus osmotic stress library Fra... 46 3.3 1 ( DN805411 ) 76947238 Sea Urchi...( CV793140 ) c-030216-1w_E04.abd cDNA library of Tamarix andro... 46 3.3 1 ( CV672849 ) RET7SJ_07D06.T7 Schistosoma japonicum re...012 2 ( CK416159 ) AUF_IpPit_34_o05 Pituitary cDNA library Ictalurus... 54 0.013 1 ( FE840166 ) CCAG48972.g1...99 ) NF075H11EC1F1095 Elicited cell culture Medicago t... 48 0.20 2 ( BF647354 ) NF075A06EC1F1040 Elicited cell culture Medic

Development status of the HTGR in the world. Outline and construction status of the demonstration HTGR program (HTR-PM) of China

International Nuclear Information System (INIS)

Ohashi, Kazutaka; Okamoto, Futoshi; Mouri, Tomoaki; Saito, Masanao; Nishio, Hiroki; Ohashi, Junpei

2014-01-01

Based on successful construction and operation experiences of HTR-10 reactor with pebble bed fuel and helium coolant, HTR-PM (HTR Pebble-bed Modular) reactor program was under way with 200 MWe of twin reactors with the same core configuration as HTR-10 reactor, which, each with a single steam generator, would drive a single steam turbine. Core height was 11 meters, and main steam temperature would be at 566 C. Although HTR-PM reactor program was interrupted by effects of the Fukushima accident, first concrete basement construction was started in December 2012 with aiming at connecting the Grid in 2017. This article reviewed outline and construction status of HTR-PM reactor in China. (T. Tanaka)

Dicty_cDB: Contig-U06515-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available bicolorF (DH5a methyl filtered) S... 46 1.5 1 ( FL639764 ) TG_26_G7 Termite gut library Reticuliterm...0375 ) 1092960187571 Global-Ocean-Sampling_GS-31-01-01-1... 44 6.0 1 ( CT500356 ) A BAC library has been constructed...01013_1( AK301013 |pid:none) Homo sapiens cDNA FLJ60076 complet... 54 4e-06 EU973819_1( EU973819 |pid:none) ...K290984 |pid:none) Homo sapiens cDNA FLJ75459 complet... 51 2e-05 CP001097_2035( CP001097 |pid:none) Chlorobium lim... ( EJ751844 ) 1092963041016 Global-Ocean-Sampling_GS-30-02-01-1... 46 1.5 1 ( EJ5

The C++ programming language

CERN Document Server

Stroustrup, Bjarne

2013-01-01

The new C++11 standard allows programmers to express ideas more clearly, simply, and directly, and to write faster, more efficient code. Bjarne Stroustrup, the designer and original implementer of C++, has updated his definitive reference and tutorial for everyone who uses the language and needs to understand its latest version. The C++ Programming Language, Fourth Edition, delivers meticulous, richly explained, and integrated coverage of the entire language—its facilities, abstraction mechanisms, standard libraries, and key design techniques. Throughout, Stroustrup presents concise, “pure C++11” examples, which have been carefully crafted to clarify both usage and program design. To promote deeper understanding, the author provides extensive cross-references, both within the book and to the ISO standard.

Determining Safety Inspection Thresholds for Employee Incentives Programs on Construction Sites.

Science.gov (United States)

Sparer, Emily; Dennerlein, Jack

2013-01-01

The goal of this project was to evaluate approaches of determining the numerical value of a safety inspection score that would activate a reward in an employee safety incentive program. Safety inspections are a reflection of the physical working conditions at a construction site and provide a safety score that can be used in incentive programs to reward workers. Yet it is unclear what level of safety should be used when implementing this kind of program. This study explored five ways of grouping safety inspection data collected during 19 months at Harvard University-owned construction projects. Each approach grouped the data by one of the following: owner, general contractor, project, trade, or subcontractor. The median value for each grouping provided the threshold score. These five approaches were then applied to data from a completed project in order to calculate the frequency and distribution of rewards in a monthly safety incentive program. The application of each approach was evaluated qualitatively for consistency, competitiveness, attainability, and fairness. The owner-specific approach resulted in a threshold score of 96.3% and met all of the qualitative evaluation goals. It had the most competitive reward distribution (only 1/3 of the project duration) yet it was also attainable. By treating all workers equally and maintaining the same value throughout the project duration, this approach was fair and consistent. The owner-based approach for threshold determination can be used by owners or general contractors when creating leading indicator incentives programs and by researchers in future studies on incentive program effectiveness.

Wetlands Research Program. Corps of Engineers Wetlands Delineation Manual. Appendix C. Sections 1 and 2. Region 2 - Southeast.

Science.gov (United States)

1987-01-01

22 7.V.: 14 -1b Jil -7 1 N.- .- WETLANDS RESEARCH PROGRAM TECHNICAL REPORT Y-87-1 CORPS OF ENGINEERS WETLANDS DELINEATION MANUAL APPENDIX C SECTIONS ...ARMYLA- US Army Corps of Engineers Washington, DC 20314-1000 B , , , -I *. 4 -w *" APPENDIX C SECTION 1 NATIONAL LIST OF PLANT SPECIES THAT OCCUR IN...Redtop FACW A. hiernalia (Walter) B.S.P. Winter bent FAC A. scabra Wilid. Rough bentgrass FAC A. st~nfyaL. Carpet bentgrass FACW Aletris aurea

A Toolchain to Produce Correct-by-Construction OCaml Programs

OpenAIRE

Filliâtre , Jean-Christophe; Gondelman , Léon; Paskevich , Andrei; Pereira , Mário; Melo De Sousa , Simão

2018-01-01

This paper presents a methodology to get correct-by-construction OCaml programs using the Why3 tool. First, a formal behavioral specification is given in the form of an OCaml module signature extended with type invariants and function contracts, in the spirit of JML. Second, an implementation is written in the programming language of Why3 and then verified with respect to the specification. Finally, an OCaml program is obtained by an automated translation. Our methodology is illustrated with ...

Construction and characterization of cDNA library for IRM-2 mice

International Nuclear Information System (INIS)

Wang Qin; Li Jin; Song Li; Liu Qiang; Yue Jingyin; Mu Chuanjie; Tang Weisheng; Fan Feiyue

2010-01-01

Objective: To screen and isolate the radioresistance related genes of IRM-2 mice. Methods: cDNA library of IRM-2 mice was constructed by SMART technique. Total RNA was isolated from spleens of IRM-2 male mice. The first-strand cDNA was synthesized by using PowerScript reverse transcriptase, and double-strand cDNA was synthesized and amplified by long PCR. The PCR products were purified, digested with restriction enzyme Sfi I. The ds-cDNA fragment less than 500 bp was fractionated and ligated to the Sfi I-digested pDNR-LIB vector. The ligation mixture was transformed into E. coil DH5 α by electroporation transformation to generate the unamplified cDNA library. The quality of cDNA library was identified by PCR technique. 130 clones from cDNA library were sequenced and compared with GenBank database. Results: The cDNA library contained 2.25 x 10 6 independent clones with an average insert size of 1.2 kb. The ratio of recombination and full-length was 95% and 55%, respectively. 21 pieces of EST sequences from cDNA library were not the same as the known mice genes and registered into GenBank EST database, with registered number DW474856-DW474876. Conclusions: cDNA library of IRM-2 mice has been constructed successfully. 21 pieces of EST implies that radioresistance correlative genes may be in IRM-2 mice, which will lay a foundation for isolating and identifying radioresistance related genes in further study. (authors)

Probabilistic Programming : A True Verification Challenge

NARCIS (Netherlands)

Katoen, Joost P.; Finkbeiner, Bernd; Pu, Geguang; Zhang, Lijun

2015-01-01

Probabilistic programs [6] are sequential programs, written in languages like C, Java, Scala, or ML, with two added constructs: (1) the ability to draw values at random from probability distributions, and (2) the ability to condition values of variables in a program through observations. For a

Construction of Agrobacterium tumefaciens-mediated tomato black ring virus infectious cDNA clones.

Science.gov (United States)

Zarzyńska-Nowak, Aleksandra; Ferriol, Inmaculada; Falk, Bryce W; Borodynko-Filas, Natasza; Hasiów-Jaroszewska, Beata

2017-02-15

Tomato black ring virus (TBRV, genus Nepovirus) infects a wide range of economically important plants such as tomato, potato, tobacco and cucumber. Here, a successful construction of infectious full-length cDNA clones of the TBRV genomic RNAs (RNA1 and RNA2) is reported for the first time. The engineered constructs consisting of PCR-amplified DNAs were cloned into binary vector pJL89 immediately downstream of a double cauliflower mosaic virus (CaMV) 35S promoter, and upstream of the hepatitis delta virus (HDV) ribozyme and nopaline synthase terminator (NOS). The symptoms induced on plants agroinoculated with both constructs were indistinguishable from those caused by the wild-type virus. The infectivity of obtained clones was verified by reinoculation to Nicotiana tabacum cv. Xanthi, Chenopodium quinoa and Cucumis sativus. The presence of viral particles and RNA was confirmed by electron microscopy and reverse transcription polymerase chain reaction, respectively. Constructed full-length infectious cDNA clones will serve as an excellent tool to study virus-host-vector interactions. Copyright © 2017 Elsevier B.V. All rights reserved.

A Study of Construction Reactor Oversight Process in US

International Nuclear Information System (INIS)

Yun, I.; Kim, S. Y.; Jeong, G. Y.; Kim, S. P.

2015-01-01

This process provides a risk-informed approach such as construction significance determination process (SDP) and construction program performance index analogous to those used in the Reactor Oversight Process (ROP). The cROP has been applied to Vogtle units 3, 4 and V.C. Summer units 2, 3 under construction for the regulatory inspection. In this paper, the cROP is dissected to present its major contents and characteristics. The main features of the cROP can be summarized as followings: 1) The cROP which adopts the concept of the ROP used for operating NPPs assesses NPP under construction periodically to determine the appropriate level of regulatory response. 2) The cROP consists of three parts: the CIP, the CAP and the CEP. 3) The inspections for NPPs under construction can be categorized into three parts: vendor inspection, baseline inspection and supplemental and plant specific inspections. USNRC's regulatory resources can be used effectively based on baseline inspection, which is using ITAAC inspections. The construction SDP is used to assign the color scheme to categorize the significance of inspection findings. Regulatory actions are taken from CAM to which the significance of inspection findings input. In this paper, major contents and characteristics of USNRC's cROP have been presented

A Method of Sample Models of Program Construction in Terms of Petri Nets

Directory of Open Access Journals (Sweden)

D. I. Kharitonov

2015-01-01

Full Text Available In the article a method of automated construction of Petri nets simulating the behaviour of imperative programs is considered from the formal point of view. Petri net samples with certain characteristics are necessary in programming new algorithms for program analysis; in particular, they can be used for developing or optimizing algorithms of Petri nets compositions and decompositions, building the reachability tree, checking invariants and so on. The generation process consists of two stages. At the first stage, construction templates for a resulting net and parameters for construction are described. With the help of these parameters it is possible to regulate the final size and the absolute or relative amount of certain structures in the resulting net. At the second stage, iterative process of automated net construction is used for Petri net generation of any size, limited only by an available computer memory. In the first section of the article the minimum necessary definitions are given and a new version of Petri nets composition operation by places is introduced. Commutative and associative properties of introduced binary operation allow to synchronize any number of Petri nets in arbitrary order. Then construction template is defined as a marked Petri net with input and output interfaces and rules for templates composition using this interfaces. A number of construction templates can be united in a collection, for which the evolution rules are defined. The completeness property of a collection guarantees that the collection evolution results in a Petri net that simulates the imperative program behavior. The article provides a version of the construction templates complete collection and an example of Petri net simulating sequential imperative program construction.

[Design for constructability studies in support of the DOE ALWR (Advanced Light Water Reactor) Program

International Nuclear Information System (INIS)

1990-03-01

This technical report accounts for work performed as part of Duke Power Company's Design for Constructability Program. This program is contractual agreement AC03-86SF16566, part of the US Department of Energy's Technology Program in Support of Advanced Light Water Reactors. This report covers the period from contract inception (September 1986) through completion (March 1990). This report is divided into 4 volumes. Volume 1 includes the executive summary and significant program conclusions. The details supporting these conclusions are in Volume 3, Improving Construction Performance, and Volume 4, Enchancing Constructability Through Design. Volume 2 includes a description of the program, objectives, and approach. A significant conclusion from these discussions was the identification of a ''missing link'' in ALWR programs. With an essentially complete, certified design, the majority of the up-front planning and preparation for implementing the design can be accomplished. Though a monumental undertaking beyond the scope of this project, this up-front planning and preparation must be considered as the next logical step for standardization. Much of the planning can be repeated with future plants and marketed to recoup expenditures. Devoting resources to develop the standard design (evolutionary or passive) to a marketable, standard, and comprehensive plant package is essential to revitalizing the option of nuclear energy. The DOE should seriously consider devoting these resources as a logical extension of its ALWR support

The LHCD Launcher for Alcator C-Mod - Design, Construction, Calibration and Testing

International Nuclear Information System (INIS)

Hosea, J.; Beals, D.; Beck, W.; Bernabei, S.; Burke, W.; Childs, R.; Ellis, R.; Fredd, E.; Greenough, N.; Grimes, M.; Gwinn, D.; Irby, J.; Jurczynski, S.; Koert, P.; Kung, C.C.; Loesser, G.D.; Marmar, E.; Parker, R.; Rushinski, J.; Schilling, G.; Terry, D.; Vieira, R.; Wilson, J.R.; Zaks, J.

2005-01-01

MIT and PPPL have joined together to fabricate a high-power lower hybrid current drive (LHCD) system for supporting steady-state AT regime research on Alcator C-Mod. The goal of the first step of this project is to provide 1.5 MW of 4.6 GHz rf [radio frequency] power to the plasma with a compact launcher which has excellent spectral selectivity and fits into a single C-Mod port. Some of the important design, construction, calibration and testing considerations for the launcher leading up to its installation on C-Mod are presented here

46 CFR 167.20-1 - Construction.

Science.gov (United States)

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Construction. 167.20-1 Section 167.20-1 Shipping COAST... Requirements, Construction and Arrangement of Nautical School Ships § 167.20-1 Construction. Except as otherwise provided by law or regulations in this subpart, the following standards for construction are...

Design and construction of AT89C2051 micro controller based water level indicator for poly tank manufacturers

International Nuclear Information System (INIS)

Ashong, Cynthia Ama

2011-08-01

This project is aimed at designing and constructing an AT89C2051 Micro controller Based Water level Indicator by programming a micro controller that has high frequency, logic, clock circuitry and 2.7V to 6V operating range with 5V volts being logic level 1 and 0 Volts being logic level 0 using Assembler language and programming the AT89C2051 Microcontroller using Galep 4 programmer. The device component and assembly includes A T89C2051 Micro controller, sensor (copper probe), bread board, electric bell for alarm to indicate low water level and a bulb to indicate high water level (that is the water tank is full). The AT89C2051 Micro controller Based Water Level Indicator works by sounding a bell when the tank is empty or the water level is low and light a bulb when the poly tank is full. The boundary within which the device operates is at the upper water level and the lower water level of the device (tank). That is it can operate within the levels of high to low limit. The result is very useful since it will help in ensuring water security. It is satisfactory since the project is working and indicating that the water level is low or high (that is the tank is empty or full). (au)

ROW (Right-of-Way) interfering construction activities management program

Energy Technology Data Exchange (ETDEWEB)

Rosito, Roberta; Oliveira, Marisa; Lima, Shirley [TRANSPETRO - PETROBRAS Transporte S.A., Rio de Janeiro, RJ (Brazil)

2009-07-01

A significant portion of pipeline failures occurs due to external damage. This includes third party right of way (ROW) encroachment, which shall be identified and avoided. However, injuries caused by known and planned activities do happen. Construction of crossing or sharing ROW pipelines, crossing roads and bridges, neighboring buildings and excavations of any kind might put existing pipelines in risk. This paper presents how the TRANSPETRO ROW Interfering Construction Activities Management Program is implemented by a regional ROW maintenance department responsible for more than 3,000 km of pipelines, mostly in Rio de Janeiro and Minas Gerais states. This program is based on a TRANSPETRO procedure that was written after the publication of the Official Order number 125 of ANP (Oil, Gas and Biofuel Brazilian National Agency). Tasks from design review and approval to field construction supervision are performed by the staff responsible for the routine patrols and maintenance management. The ability of foreseeing risky activities is improved by expertise gained from day-to-day work on site. (author)

Method for construction of normalized cDNA libraries

Science.gov (United States)

Soares, Marcelo B.; Efstratiadis, Argiris

1998-01-01

This invention provides a method to normalize a directional cDNA library constructed in a vector that allows propagation in single-stranded circle form comprising: (a) propagating the directional cDNA library in single-stranded circles; (b) generating fragments complementary to the 3' noncoding sequence of the single-stranded circles in the library to produce partial duplexes; (c) purifying the partial duplexes; (d) melting and reassociating the purified partial duplexes to appropriate Cot; and (e) purifying the unassociated single-stranded circles, thereby generating a normalized cDNA library. This invention also provides normalized cDNA libraries generated by the above-described method and uses of the generated libraries.

Scalable data structure detection and classification for C/C++ binaries

NARCIS (Netherlands)

Haller, I.; Slowinska, J.M.; Bos, H.J.

2015-01-01

Many existing techniques for reversing data structures in C/C ++ binaries are limited to low-level programming constructs, such as individual variables or structs. Unfortunately, without detailed information about a program's pointer structures, forensics and reverse engineering are exceedingly

[Primary culture of cat intestinal epithelial cell and construction of its cDNA library].

Science.gov (United States)

Ye, L; Gui-Hua, Z; Kun, Y; Hong-Fa, W; Ting, X; Gong-Zhen, L; Wei-Xia, Z; Yong, C

2017-04-12

Objective To establish the primary cat intestinal epithelial cells (IECs) culture methods and construct the cDNA library for the following yeast two-hybrid experiment, so as to screen the virulence interaction factors among the final host. Methods The primary cat IECs were cultured by the tissue cultivation and combined digestion with collagenase XI and dispase I separately. Then the cat IECs cultured was identified with the morphological observation and cyto-keratin detection, by using goat anti-cyto-keratin monoclonal antibodies. The mRNA of cat IECs was isolated and used as the template to synthesize the first strand cDNA by SMART™ technology, and then the double-strand cDNAs were acquired by LD-PCR, which were subsequently cloned into the plasmid PGADT7-Rec to construct yeast two-hybrid cDNA library in the yeast strain Y187 by homologous recombination. Matchmaker™ Insert Check PCR was used to detect the size distribution of cDNA fragments after the capacity calculation of the cDNA library. Results The comparison of the two cultivation methods indicated that the combined digestion of collagenase XI and dispase I was more effective than the tissue cultivation. The cat IECs system of continuous culture was established and the cat IECs with high purity were harvested for constructing the yeast two-hybrid cDNA library. The library contained 1.1×10 6 independent clones. The titer was 2.8×10 9 cfu/ml. The size of inserted fragments was among 0.5-2.0 kb. Conclusion The yeast two-hybrid cDNA library of cat IECs meets the requirements of further screen research, and this study lays the foundation of screening the Toxoplasma gondii virulence interaction factors among the cDNA libraries of its final hosts.

Programming C# 40

CERN Document Server

Griffiths, Ian; Liberty, Jesse

2010-01-01

With its support for dynamic programming, C# 4.0 continues to evolve as a versatile language on its own. But when C# is used with .NET Framework 4, the combination is incredibly powerful. This bestselling tutorial shows you how to build web, desktop, and rich Internet applications using C# 4.0 with .NET's database capabilities, UI framework (WPF), extensive communication services (WCF), and more. In this sixth edition, .NET experts Ian Griffiths, Matthew Adams, and Jesse Liberty cover the latest enhancements to C#, as well as the fundamentals of both the language and framework. You'll learn

Economic efficiency of high-rise construction in the Moscow program of renovation of housing stock

Science.gov (United States)

Misailovov, Andrey

2018-03-01

The article considers a new initiative of the regional authorities of updating the housing stock designated as the renovation of housing. Its main aspects are analyzed, including the nature of program, economic efficiency of its implementation due to high-rise construction and the regulatory and legislative framework, the procedure for implementing the program, and the time frame for its implementation. The role of the program for regions in which high depreciation of the housing stock is combined with a limited number of sites for a new housing construction is disclosed. The high-rise construction in the renovation program is presented as a variant of a successful solution not only of the tasks of renovating the housing stock, but also of filling the regional budget. The social and economic orientation of the high-rise construction and the involvement of residents in the process of making town-planning decisions in the field of high-rise construction at all stages of implementing the program are shown.

Careers in Construction: Construction Industry Series: Student Manual and Instructor's Guide.

Science.gov (United States)

Texas Education Agency, Austin. Dept. of Occupational Education and Technology.

The guide for instructors of construction occupations provides instructional suggestions and informational sources for structuring an exploratory program. The program is divided into the following blocks, representing different experiences in construction: (1) wood; (2) finishing; (3) engineering, support, and management services; (4) metal; (5)…

Construction and identification of subtracted cDNA library in bone marrow cells of radon-exposed mice

International Nuclear Information System (INIS)

Li Jianxiang; Nie Jihua; Tong Jian; Fu Chunling; Zhou Jianwei

2008-01-01

Objective: To construct and identify subtracted cDNA library in bone marrow cells of mice exposed to radon inhalation. Methods: Adult male BALB/c mice, weighing 18-22 g, were placed in a multi- functional radon chamber. One group of mice was exposed to radon up to the accumulative dose of 105 work level month (WLM). The control group of mice was housed in a room with an accumulative dose of 1 WLM. To construct a subtracted cDNA library enriched with differentially expressed genes, the SMART technique and the suppression subtractive hybridization were performed. The obtained forward and reverse cDNA fragments were directly inserted into pMD18-T vector and transformed into E. coli JM109. The inserting cDNA fragments were screened by the blue-and-white blot screening and nested PCR of bacterium liquid. Results: The 244 of 285 white bacteria clones obtained randomly were positive clones contained 100-1100 bp inserted cDNA fragments. Conclusions: The forward and reverse subtracted cDNA library in bone marrow cells of mice exposed to radon inhalation is successfully constructed. (authors)

Development of support tools for efficient construction of dynamic simulation program for engineering systems

International Nuclear Information System (INIS)

Gofuku, Akio

1993-01-01

In this study, two support tools are developed for construction of a dynamic simulation program for engineering systems (especially nuclear systems) by combining software modules. These are (1) a sub-system to support the module selection suitable for dynamic simulation and (2) a graphical user interface to support visual construction of simulation programs. The support tools are designed to be independent on the conception of software modules (data communication methods between modules). In the module selection sub-system of item 1, a module is characterized beforehand by keywords for several criteria. The similarity between the characteristic of requested module by users and that of registered modules in the module library is estimated by a weighted average of similarity indexes for criteria. In the module selection sub-system, the weights are flexibly extracted from users by applying the analytic hierarchy process. The graphical user interface helps users to specify both calling order of modules and data transfer between two modules. The availability of the support tools is evaluated by several sample problems of module selection and dynamic simulation model construction. The support tools will be a strong tool for the efficient usage of software modules. (author)

12 CFR 410.151 - Program accessibility: New construction and alterations.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Program accessibility: New construction and alterations. 410.151 Section 410.151 Banks and Banking EXPORT-IMPORT BANK OF THE UNITED STATES ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY EXPORT-IMPORT BANK OF THE UNITED...

Practical C++ financial programming

CERN Document Server

Oliveira, Carlos

2015-01-01

Practical C++ Financial Programming is a hands-on book for programmers wanting to apply C++ to programming problems in the financial industry. The book explains those aspects of the language that are more frequently used in writing financial software, including the STL, templates, and various numerical libraries. The book also describes many of the important problems in financial engineering that are part of the day-to-day work of financial programmers in large investment banks and hedge funds. The author has extensive experience in the New York City financial industry that is now distilled in

Electrodril system field test program. Phase II: Task C-1-deep drilling system demonstration. Final report for Phase II: Task C-1

Energy Technology Data Exchange (ETDEWEB)

Taylor, P D

1981-04-01

The Electrodril Deep Drilling System field test demonstrations were aborted in July 1979, due to connector problems. Subsequent post test analyses concluded that the field replacable connectors were the probable cause of the problems encountered. The designs for both the male and female connectors, together with their manufacturing processes, were subsequently modified, as was the acceptance test procedures. A total of nine male and nine female connectors were manufactured and delivered during the 2nd Quarter 1980. Exhaustive testing was then conducted on each connector as a precursor to formal qualification testing conducted during the month of October 1980, at the Brown Oil Tool test facility located in Houston, Texas. With this report, requirements under Phase II, Task C-1 are satisfied. The report documents the results of the connector qualification test program which was successfully completed October 28, 1980. In general, it was concluded that connector qualification had been achieved and plans are now in progress to resume the field test demonstration program so that Electrodril System performance predictions and economic viability can be evaluated.

48 CFR 252.225-7045 - Balance of Payments Program-Construction Material Under Trade Agreements.

Science.gov (United States)

2010-10-01

.... Designated country means— (1) A World Trade Organization Government Procurement Agreement (WTO GPA) country... another country, has been substantially transformed in a Free Trade Agreement country into a new and... Program-Construction Material Under Trade Agreements. 252.225-7045 Section 252.225-7045 Federal...

40 CFR 40.115-1 - Construction.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Construction. 40.115-1 Section 40.115-1... DEMONSTRATION GRANTS § 40.115-1 Construction. May include the preliminary planning to determine the economic and... action necessary to the construction of a facility, the erection, acquisition, alteration, remodeling...

Detecting C Program Vulnerabilities

OpenAIRE

Anton, Ermakov; Natalia, Kushik

2011-01-01

C/C++ language is widely used for developing tools in various applications, in particular, software tools for critical systems are often written in C language. Therefore, the security of such software should be thoroughly tested, i.e., the absence of vulnerabilities has to be confirmed. When detecting C program vulnerabilities static source code analysis can be used. In this paper, we present a short survey of existing software tools for such analysis and show that for some kinds of C code vu...

MemPick : High-level data structure detection in C/C++ binaries

NARCIS (Netherlands)

Haller, Istvan; Slowinska, Asia; Bos, Herbert

2013-01-01

Many existing techniques for reversing data structures in C/C++ binaries are limited to low-level programming constructs, such as individual variables or structs. Unfortunately, without detailed information about a program's pointer structures, forensics and reverse engineering are exceedingly hard.

Knowledge, programming, and programming cultures: LISP, C, and Ada

Science.gov (United States)

Rochowiak, Daniel

1990-01-01

The results of research 'Ada as an implementation language for knowledge based systems' are presented. The purpose of the research was to compare Ada to other programming languages. The report focuses on the programming languages Ada, C, and Lisp, the programming cultures that surround them, and the programming paradigms they support.

Efficient detection of dangling pointer error for C/C++ programs

Science.gov (United States)

Zhang, Wenzhe

2017-08-01

Dangling pointer error is pervasive in C/C++ programs and it is very hard to detect. This paper introduces an efficient detector to detect dangling pointer error in C/C++ programs. By selectively leave some memory accesses unmonitored, our method could reduce the memory monitoring overhead and thus achieves better performance over previous methods. Experiments show that our method could achieve an average speed up of 9% over previous compiler instrumentation based method and more than 50% over previous page protection based method.

Beginning programming with C for dummies

CERN Document Server

Gookin, Dan

2013-01-01

Learn the basics of programming with C with this fun and friendly guide! C offers a reliable, strong foundation for programming and serves as a stepping stone upon which to expand your knowledge and learn additional programming languages. Written by veteran For Dummies author Dan Gookin, this straightforward-but-fun beginner's guide covers the fundamentals of using C and gradually walks you through more advanced topics including pointers, linked lists, file I/O, and debugging. With a special focus on the subject of an Integrated Development Environment, it gives you a solid understanding of

Computer aided construction of fault tree

International Nuclear Information System (INIS)

Kovacs, Z.

1982-01-01

Computer code CAT for the automatic construction of the fault tree is briefly described. Code CAT makes possible simple modelling of components using decision tables, it accelerates the fault tree construction process, constructs fault trees of different complexity, and is capable of harmonized co-operation with programs PREPandKITT 1,2 for fault tree analysis. The efficiency of program CAT and thus the accuracy and completeness of fault trees constructed significantly depends on the compilation and sophistication of decision tables. Currently, program CAT is used in co-operation with programs PREPandKITT 1,2 in reliability analyses of nuclear power plant systems. (B.S.)

Construction of cDNA libraries from Pseudocercospora fijiensis Morelet infected leaves of the cultivars Calcutta 4 and Niyarma Yik

Directory of Open Access Journals (Sweden)

Milady Mendoza-Rodríguez

2004-01-01

Full Text Available Molecular studies of plant-pathogen interaction are very important for the identification of gene (s related with the pathogenic process, as well as with the plant resistance. These gene (s could be use for the genetic improvement programs in order to obtain resistant cultivars. The aim of this work was to construct complementary DNA (cDNA libraries from infected leaves with Pseudocercospora fijiensis CCIBP-Pf1 isolated of two banana cultivars (a resistant one Calcutta4 and another one susceptible Niyarma Yik. First-strand cDNA synthesis, was made beginning with one microgram of total RNA by using oligo dT primer and cDNA quality was checked by Polimerase chain reaction (PCR with cytochrome b specific primers. Second-strand cDNA synthesis was performed by using the homopolymeric tailing with dC-BamH I + dT-Not I primer combination. Four cDNA libraries of infected plants at different times of infection with the pathogen were obtained. Forty one clones of one of the libraries of Niyarma Yik were sequenced and the obtained sequences correspond with genes related to fungi. Key words: Banana-Mycosphaerella fijiensis interaction,Black Sigatoka, Musa spp.

Financial Awareness Education with Apprentices in the Australian Construction Industry: Program Evaluation

Science.gov (United States)

Du Plessis, Karin; Green, Emma

2013-01-01

A financial awareness education program was implemented with construction industry apprentices in Victoria, Australia. The program included face-to-face delivery of education around a range of financial management issues that apprentices face as they begin their apprenticeship. The paper reports on an evaluation of the program, which included…

Hydrogen sulfide flux measurements from construction and demolition debris (C&D) landfills.

Science.gov (United States)

Eun, Sangho; Reinhart, Debra R; Cooper, C David; Townsend, Timothy G; Faour, Ayman

2007-01-01

Hydrogen sulfide (H2S) has been identified as a principal odorous component of gaseous emissions from construction and demolition debris (C&D) landfills. Although several studies have reported the ambient concentrations of H2S near C&D landfills, few studies have quantified emission rates of H2S. One of the most widely used techniques for measuring surface gas emission rates from landfills is the flux chamber method. Flux measurements using the flux chamber were performed at five different C&D landfills from April to August, 2003. The flux rates of H2S measured in this research were between 0.192 and 1.76 mg/(m2-d).

Dicty_cDB: Contig-U12726-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available ( DU826786 ) FLAS_CR30-2002_05F11.T7M FLAS_CR30-2002 unculture... 46 0.41 1 ( AL404104 ) T3 end of clone AT0AA013B12 of library...mid clone: MOF-010N15, gen... 46 0.41 1 ( CT559968 ) A BAC library has been constructed from cultivar ... 46...1 ( BG450438 ) NF015E06DT1F1051 Drought Medicago truncatula cDNA... 50 0.027 1 ( BF649099 ) NF055E07EC1F1053 Elicited cell culture... Medicago t... 50 0.027 1 ( BF644378 ) NF061A10EC1F1072 Elicited cell culture Medicago...M0435G20F Mouse 10kb plasmid UUGC1M library Mus ... 48 0.10 1 ( AL405948 ) T7 end of clone AU0AA007C03 of library

48 CFR 53.236-1 - Construction.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Construction. 53.236-1... AND FORMS FORMS Prescription of Forms 53.236-1 Construction. The following forms are prescribed, as stated below, for use in contracting for construction, alteration, or repair, or dismantling, demolition...

An Environmental Management Maturity Model of Construction Programs Using the AHP-Entropy Approach

Directory of Open Access Journals (Sweden)

Libiao Bai

2018-06-01

Full Text Available The accelerating process of urbanization in China has led to considerable opportunities for the development of construction projects, however, environmental issues have become an important constraint on the implementation of these projects. To quantitatively describe the environmental management capabilities of such projects, this paper proposes a 2-dimensional Environmental Management Maturity Model of Construction Program (EMMMCP based on an analysis of existing projects, group management theory and a management maturity model. In this model, a synergetic process was included to compensate for the lack of consideration of synergies in previous studies, and it was involved in the construction of the first dimension, i.e., the environmental management index system. The second dimension, i.e., the maturity level of environment management, was then constructed by redefining the hierarchical characteristics of construction program (CP environmental management maturity. Additionally, a mathematical solution to this proposed model was derived via the Analytic Hierarchy Process (AHP-entropy approach. To verify the effectiveness and feasibility of this proposed model, a computational experiment was conducted, and the results show that this approach could not only measure the individual levels of different processes, but also achieve the most important objective of providing a reference for stakeholders when making decisions on the environmental management of construction program, which reflects this model is reasonable for evaluating the level of environmental management maturity in CP. To our knowledge, this paper is the first study to evaluate the environmental management maturity levels of CP, which would fill the gap between project program management and environmental management and provide a reference for relevant management personnel to enhance their environmental management capabilities.

COOPERATIVE RESEARCH IN C1 CHEMISTRY

Energy Technology Data Exchange (ETDEWEB)

Gerald P. Huffman

2001-04-30

Faculty and students from five universities (Kentucky, West Virginia, Utah, Pittsburgh and Auburn) are collaborating on a basic research program to develop novel C1 chemistry processes for the production of clean, high quality transportation fuel. An Industrial Advisory Board (IAB) with members from Chevron, Eastman Chemical, Energy International, Teir Associates, and the Department of Defense has been formed to provide practical guidance to the program. The program has two principal objectives. (1) Develop technology for conversion of C1 source materials (natural gas, synthesis gas, carbon dioxide and monoxide, and methanol) into clean, high efficiency transportation fuel. (2) Develop novel processes for producing hydrogen from natural gas and other hydrocarbons. Some of the principal accomplishments of the program in its first two years are: (1) The addition of acetylenic compounds in Fischer-Tropsch synthesis is found to produce significant amounts of oxygenated products in FT diesel fuels. Such oxygenated products should decrease particulate matter (PM) emissions. (2) Nanoscale, binary, Fe-based catalysts supported on alumina have been shown to have significant activity for the decomposition of methane into pure hydrogen and potentially valuable multi-walled carbon nanotubes. (3) Catalytic synthesis processes have been developed for synthesis of diethyl carbonate, higher ethers, and higher alcohols from C1 source materials. Testing of the effect of adding these oxygenates to diesel fuel on PM emissions has begun using a well-equipped small diesel engine test facility. (4) Supercritical fluid (SCF) FT synthesis has been conducted under SCF hexane using both Fe and Co catalysts. There is a marked effect on the hydrocarbon product distribution, with a shift to higher carbon number products. These and other results are summarized.

26 CFR 1.127-1 - Amounts received under a qualified educational assistance program.

Science.gov (United States)

2010-04-01

... employee under a qualified educational assistance program described in § 1.127-2, or (2) The value of... Income § 1.127-1 Amounts received under a qualified educational assistance program. (a) Exclusion from.... (c) Amounts received under a nonqualified program. Any amount received under an educational...

25 CFR 170.404 - What happens when a tribe uses its IRR Program construction funds for transportation planning?

Science.gov (United States)

2010-04-01

... of Indian Reservation Roads Program Facilities Transportation Planning § 170.404 What happens when a... 25 Indians 1 2010-04-01 2010-04-01 false What happens when a tribe uses its IRR Program construction funds for transportation planning? 170.404 Section 170.404 Indians BUREAU OF INDIAN AFFAIRS...

Concept document of the repository-based software engineering program: A constructive appraisal

Science.gov (United States)

1992-01-01

A constructive appraisal of the Concept Document of the Repository-Based Software Engineering Program is provided. The Concept Document is designed to provide an overview of the Repository-Based Software Engineering (RBSE) Program. The Document should be brief and provide the context for reading subsequent requirements and product specifications. That is, all requirements to be developed should be traceable to the Concept Document. Applied Expertise's analysis of the Document was directed toward assuring that: (1) the Executive Summary provides a clear, concise, and comprehensive overview of the Concept (rewrite as necessary); (2) the sections of the Document make best use of the NASA 'Data Item Description' for concept documents; (3) the information contained in the Document provides a foundation for subsequent requirements; and (4) the document adequately: identifies the problem being addressed; articulates RBSE's specific role; specifies the unique aspects of the program; and identifies the nature and extent of the program's users.

Construction of Infectious cDNA Clone of a Chrysanthemum stunt viroid Korean Isolate

Directory of Open Access Journals (Sweden)

Ju-Yeon Yoon

2014-03-01

Full Text Available Chrysanthemum stunt viroid (CSVd, a noncoding infectious RNA molecule, causes seriously economic losses of chrysanthemum for 3 or 4 years after its first infection. Monomeric cDNA clones of CSVd isolate SK1 (CSVd-SK1 were constructed in the plasmids pGEM-T easy vector and pUC19 vector. Linear positive-sense transcripts synthesized in vitro from the full-length monomeric cDNA clones of CSVd-SK1 could infect systemically tomato seedlings and chrysanthemum plants, suggesting that the linear CSVd RNA transcribed from the cDNA clones could be replicated as efficiently as circular CSVd in host species. However, direct inoculation of plasmid cDNA clones containing full-length monomeric cDNA of CSVd-SK1 failed to infect tomato and chrysanthemum and linear negative-sense transcripts from the plasmid DNAs were not infectious in the two plant species. The cDNA sequences of progeny viroid in systemically infected tomato and chrysanthemum showed a few substitutions at a specific nucleotide position, but there were no deletions and insertions in the sequences of the CSVd progeny from tomato and chrysanthemum plants.

Runtime Verification of C Programs

Science.gov (United States)

Havelund, Klaus

2008-01-01

We present in this paper a framework, RMOR, for monitoring the execution of C programs against state machines, expressed in a textual (nongraphical) format in files separate from the program. The state machine language has been inspired by a graphical state machine language RCAT recently developed at the Jet Propulsion Laboratory, as an alternative to using Linear Temporal Logic (LTL) for requirements capture. Transitions between states are labeled with abstract event names and Boolean expressions over such. The abstract events are connected to code fragments using an aspect-oriented pointcut language similar to ASPECTJ's or ASPECTC's pointcut language. The system is implemented in the C analysis and transformation package CIL, and is programmed in OCAML, the implementation language of CIL. The work is closely related to the notion of stateful aspects within aspect-oriented programming, where pointcut languages are extended with temporal assertions over the execution trace.

The molecular spin filter constructed from 1D organic chain

International Nuclear Information System (INIS)

Chen, Wei; Xu, Ning; Wang, Baolin; Bian, Baoan

2014-01-01

We proposed a molecular spin filter, which is constructed from the 1D metallic organic chain (Fe n+1 (C 6 H 4 ) n ). The spin-polarized transport properties of the molecular spin filter are explored by combining density functional theory with nonequilibrium Green's function formalism. Theoretical results reveal that Fe n+1 (C 6 H 4 ) n molecular chain exhibits robust spin filtering effect, and only the spin-down electrons can transmit through the molecular chain. At the given bias voltage window [−1 eV,1 eV], the calculated spin filter efficiency is close to 100% in the case of n≥3. We find that the effect of spin polarization origin from both Fe n+1 and (C 6 H 4 ) n . In addition, negative difference resistance behavior appears in Fe n+1 (C 6 H 4 ) n molecular chain. The results can help us understand the spin transport properties of organic molecular chain. - Highlights: • Theoretical results reveal that Fe n+1 (C 6 H 4 ) n molecular chain exhibits robust spin filtering effect. • The effect of spin polarization origin from both of Fe n+1 and (C 6 H 4 ) n . • Negative difference resistance behavior appears in Fe n+1 (C 6 H 4 ) n molecular chain

Programming with C++

CERN Document Server

Juneja, BL

2009-01-01

About the Book: Authors have taken special care to present the various topics in Programming with C++ in an easy-to-learn style. Almost every topic is followed by well designed live programmes so that it becomes easy to grasp the underlying principle or programming technique. A total of more than 450 live programmes are included in the book. It is also taken care that programmes are short and do not include such details which do not relate to the topic on hand. This makes them easy to be tested and suitable for practice students. Authors are confident that the book will prove its worth for th

Producing Reality Stardom: Constructing, Programming, and Branding Celebrity on Reality Television

OpenAIRE

Giggey, Lindsay Nicole

2017-01-01

The popular preoccupation with celebrity in American culture in the past decade has been bolstered by a corresponding increase in the amount of reality programming across cable and broadcast networks that centers either on established celebrities or on celebrities in the making. This dissertation examines the questions: How is celebrity constructed, scheduled, and branded by networks, production companies, and individual participants, and how do the constructions and mechanisms of celebrity i...

20 CFR 655.1111 - Element I-What hospitals are eligible to participate in the H-1C program?

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Element I-What hospitals are eligible to participate in the H-1C program? 655.1111 Section 655.1111 Employees' Benefits EMPLOYMENT AND TRAINING... Internet website at http://www.access.gpo.gov. (d) To make a determination about information in the settled...

Dicty_cDB: Contig-U05453-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available 4_N20_R IASMA L1 HindIII BAC library Vitis v... 44 1.6 1 ( DU234107 ) 1098574026029 CHORI-243 Ovis aries genomic... clone ... 44 1.6 1 ( CW007337 ) ZMMBLa0008O17.f ZMMBLa Zea mays genomic clone ZMM... 44 1.6 1 ( CU838323 ) A BAC library... EST Darmstadt I Hydra magnipapi... 44 1.6 1 ( BM439300 ) GIT0000114 Root-induced cDNA library from Glomus .... mays chromosome 8 clone CH201-12I21; ZMMBBc00... 44 1.6 1 ( AZ319107 ) 1M0038L02R Mouse 10kb plasmid UUGC1M library... has been constructed from PN40024 g... 44 1.6 1 ( CT525490 ) A BAC library

Development and construct validation of the Client-Centredness of Goal Setting (C-COGS) scale.

Science.gov (United States)

Doig, Emmah; Prescott, Sarah; Fleming, Jennifer; Cornwell, Petrea; Kuipers, Pim

2015-07-01

Client-centred philosophy is integral to occupational therapy practice and client-centred goal planning is considered fundamental to rehabilitation. Evaluation of whether goal-planning practices are client-centred requires an understanding of the client's perspective about goal-planning processes and practices. The Client-Centredness of Goal Setting (C-COGS) was developed for use by practitioners who seek to be more client-centred and who require a scale to guide and evaluate individually orientated practice, especially with adults with cognitive impairment related to acquired brain injury. To describe development of the C-COGS scale and examine its construct validity. The C-COGS was administered to 42 participants with acquired brain injury after multidisciplinary goal planning. C-COGS scores were correlated with the Canadian Occupational Performance Measure (COPM) importance scores, and measures of therapeutic alliance, motivation, and global functioning to establish construct validity. The C-COGS scale has three subscales evaluating goal alignment, goal planning participation, and client-centredness of goals. The C-COGS subscale items demonstrated moderately significant correlations with scales measuring similar constructs. Findings provide preliminary evidence to support the construct validity of the C-COGS scale, which is intended to be used to evaluate and reflect on client-centred goal planning in clinical practice, and to highlight factors contributing to best practice rehabilitation.

Effective Analysis of C Programs by Rewriting Variability

DEFF Research Database (Denmark)

Iosif-Lazar, Alexandru Florin; Melo, Jean; Dimovski, Aleksandar

2017-01-01

and effective analysis and verification of real-world C program families. Importance. We report some interesting variability-related bugs that we discovered using various state-of-the-art single-program C verification tools, such as Frama-C, Clang, LLBMC.......Context. Variability-intensive programs (program families) appear in many application areas and for many reasons today. Different family members, called variants, are derived by switching statically configurable options (features) on and off, while reuse of the common code is maximized. Inquiry....... Verification of program families is challenging since the number of variants is exponential in the number of features. Existing single-program analysis and verification tools cannot be applied directly to program families, and designing and implementing the corresponding variability-aware versions is tedious...

The ABCs of diabetes: diabetes self-management education program for African Americans affects A1C, lipid-lowering agent prescriptions, and emergency department visits.

Science.gov (United States)

Magee, Michelle; Bowling, Andrea; Copeland, James; Fokar, Ali; Pasquale, Patricia; Youssef, Gretchen

2011-01-01

The purpose of the study was to examine the feasibility and impact of a concise community-based program on diabetes self-management education (DSME), according to frequency of emergency department visits and knowledge of, prescriptions for, and control of A1C, blood pressure, and low-density lipoprotein (LDL) cholesterol. A free community-based DSME program was placed in a public library. Adults with diabetes (N, 360) consented to participate in this prospective nonrandomized cohort study with preintervention-postintervention design. The small-group interactive DSME (two 2.5-hour classes) focused on improving cardiovascular disease risk factors and facilitating communication with the primary care physician. An increase in knowledge of American Diabetes Association-recommended targets for A1C, blood pressure, and LDL cholesterol from baseline to postintervention was seen among participants. Significant clinical outcomes included reduction in self-reported emergency department visits and reduction in mean A1C. However, despite an increase in prescriptions written for lipid-lowering drugs, blood pressure and LDL cholesterol did not change. Participants who started on insulin were more likely to achieve or maintain A1C location for offering DSME programs.

Assumption and program of the earlier stage construction of L/ILW disposal site

International Nuclear Information System (INIS)

Li Xuequn; Chen Shi; Li Xinbang

1993-01-01

The authors analysed the production and treatment of low- and intermediate-level radwastes (L/ILW) in China. Some problems and situation in this field are introduced. Over the past ten years, preliminary efforts have been made by CNNC (China National Nuclear Corporation) in policy, law and rules, developing program, management system, siting, engineering techniques, and safety assessment for radwaste disposal. The investment of the earlier stage work of L/ILW disposal site construction is estimated, the program and assumption to disposal site construction of the L/ILW are reviewed

NEW INSTRUMENTS FOR MANAGEMENT OF CONSTRUCTION PROGRAMS AND PROJECTS IN THE NEW ECONOMY STRUCTURE

Directory of Open Access Journals (Sweden)

Silka Dmitriy Nikolaevich

2017-11-01

Full Text Available Subject: the new economy structure is directly related to the active application of digital technologies. Economic processes are more formalized and for making administrative decisions it becomes possible to operate in a greater degree with precise criteria and information than probabilistic assumptions. As a subject of research, new tools for managing construction programs and projects are presented. Research objectives: the purpose of the study is to formulate general principles and directions for the digitization of economic relations in investment and construction activities to ensure the effectiveness of implementation of new generation projects. Materials and methods: to achieve the goal, the article shows the composition of state programs and projects in the construction sector and the system problems of their implementation. Organizational methods of increasing their effectiveness are considered. Results: the most promising areas of implementation of new management tools for investment and construction programs and projects are identified. Conclusions: the article shows the current dynamics of changes in technical and socio-economic systems at the level of construction sector. It is pointed out that the tasks of socio-economic nature require the development of unique approaches since the peculiarities of Russian legislation, of the prevailing norms and rules of economic activity prevent the direct replication of successful foreign experience.

Functional Programming with C++ Template Metaprograms

Science.gov (United States)

Porkoláb, Zoltán

Template metaprogramming is an emerging new direction of generative programming. With the clever definitions of templates we can force the C++ compiler to execute algorithms at compilation time. Among the application areas of template metaprograms are the expression templates, static interface checking, code optimization with adaption, language embedding and active libraries. However, as template metaprogramming was not an original design goal, the C++ language is not capable of elegant expression of metaprograms. The complicated syntax leads to the creation of code that is hard to write, understand and maintain. Although template metaprogramming has a strong relationship with functional programming, this is not reflected in the language syntax and existing libraries. In this paper we give a short and incomplete introduction to C++ templates and the basics of template metaprogramming. We will enlight the role of template metaprograms, and some important and widely used idioms. We give an overview of the possible application areas as well as debugging and profiling techniques. We suggest a pure functional style programming interface for C++ template metaprograms in the form of embedded Haskell code which is transformed to standard compliant C++ source.

CoC Awards by Program Component

Data.gov (United States)

Department of Housing and Urban Development — CoC Awards by Program Component reports provide snapshots of award data broken down by eligible program component types for the year selected. The reports, which can...

Summary of breakout Session C1: C1, chemical countermeasures; dispersants

International Nuclear Information System (INIS)

Anon.

1992-01-01

The discussions in breakout session C1 are summarized. The topics discussed include the pros and cons of dispersant use. Many of the positions which have been heard for the last twenty years were restated. Neither group convinced the other of the advisability of easing the use of dispersants. There was better agreement on the need for research and development programs to get a better handle on some of the questions being raised. The R ampersand D needs on which the participants could agree are summarized

Object-oriented design and programming with C++ your hands-on guide to C++ programming, with special emphasis on design, testing, and reuse

CERN Document Server

Leach, Ronald

2014-01-01

Object-Oriented Design and Programming with C++: Your Hands-On Guide to C++ Programming, with Special Emphasis on Design, Testing, and Reuse provides a list of software engineering principles to guide the software development process. This book presents the fundamentals of the C++ language.Organized into two parts encompassing 10 chapters, this book begins with an overview of C++ and describes object-oriented programming and the history of C++. This text then introduces classes, polymorphism, inheritance, and overloading. Other chapters consider the C++ preprocessor and organization of class l

C programming language essentials

CERN Document Server

Ackermann, Ernest C

2012-01-01

REA's Essentials provide quick and easy access to critical information in a variety of different fields, ranging from the most basic to the most advanced. As its name implies, these concise, comprehensive study guides summarize the essentials of the field covered. Essentials are helpful when preparing for exams, doing homework and will remain a lasting reference source for students, teachers, and professionals. C Programming Language discusses fundamental notions, data types and objects, expressions, statements, declarations, function and program structure, the preprocessor, and the standar

Constructing Adult Literacies at a Local Literacy Tutor-Training Program

Science.gov (United States)

Roderick, Ryan

2013-01-01

This study investigates how literacy was constructed at an adult literacy organization's volunteer tutor-training program. By drawing on qualitative analysis of training texts used during training, such as training evaluations, and data gathered from interviews with experienced tutors, it is possible to identify the assumptions about literacy…

Construction of RNAi lentiviral vector targeting mouse Islet-1 gene

Directory of Open Access Journals (Sweden)

Shen-shen ZHI

2011-02-01

Full Text Available Objective To construct and select RNAi lentiviral vectors that can silence mouse Islet-1 gene effectively.Methods Three groups of RNAi-target of mouse Islet-1 gene were designed,and corresponding shRNA oligo(sh1,sh2 and sh3 were synthesized,and then they were respectively inserted to the PLVTHM vector that had been digested by endonuclease.Agarose gel electrophoresis and sequencing were used to select and indentify the positive clones.The positive clones were extracted and then mixed with E.coli to amplify positive clones.The amplified clones were then infected into 293T along with the other 3 helper plasmids to produce lentiviral vector.After the construction of the lentiviral vector,plaque formation test was performed to determine the titer of lentiviral vector.The lentiviral vectors were then infected into C3H10T1/2 cells.The transfect efficiency of the lentiviral vectors was determined with flow cytometry with detection of green fluorescent protein(GFP.Q-PCR was employed to detect the RNAi efficiency of the lentiviral vectors.Results Agarose gel electrophoresis analysis showed that the clones with right gene at the target size were successfully established;gene sequencing showed that the right DNA fragments had been inserted;plaque formation test showed that the titer of the virus solution was 3.87×108TU/ml;the transfect efficiency of the lentiviral vector infected into C3H10T1/2 cells was 90.36%.All the 3 groups of shRNA targets(sh1,sh2 and sh3 showed an inhibitory effect on Islet-1 gene,and the sh1 showed the highest inhibitory effect(76.8%,as compared with that of normal cells(P < 0.05.Conclusion The RNAi lentiviral vector that can effectively silence the mouse Islet-1 gene has been constructed successfully,which may lay a foundation for further investigation of Islet-1 gene.

C-SAFE: A Computer-Delivered Sexual Health Promotion Program for Latinas.

Science.gov (United States)

Klein, Charles H; Kuhn, Tamara; Altamirano, Midori; Lomonaco, Carmela

2017-07-01

This article describes the development and evaluation of C-SAFE (Sexual Awareness for Everyone), a computer-delivered sexual health promotion program for Latinas. We first describe the process of adapting an evidence-based, group-level intervention into an individually administered computer-delivered program. We then present the methods and results of a randomized control trial with 321 Latinas in California and Florida to test C-SAFE's preliminary efficacy in reducing sexual health risk. We found no statistically significant differences between the two conditions at a six-month follow-up in terms of sexual behaviors or attitudes toward sexually transmitted infections and condoms, although C-SAFE women reported fewer days in the past month when their mental health was not good (p = .02). C-SAFE condition women also reported more satisfaction than control condition women in their assessment of information presentation (on a scale of 1 = poor and 5 = excellent; C-SAFE = 4.45 vs. control = 4.25, p = .053) and having learned something new (C-SAFE = 95.1% vs. control = 79.3%, χ 2 importance of teachable moments, matching of delivery modalities to implementation contexts, and possible directions for evidence-based sexual health promotion programs given the current sexual health landscape.

A computer-oriented approach to fault-tree construction. Topical report No. 1

International Nuclear Information System (INIS)

Chu, B.B.

1976-11-01

Fault Tree Analysis is one of the major tools for the safety and reliability analysis of large systems. A methodology for systematically constructing fault trees for general complex systems is developed and applied, via the computer program CAT, to several systems. First, a means of representing component behavior by decision tables is presented. In order to use these tables, a procedure for constructing and editing fault trees, either manually or by computer, is described. In order to verify the methodology the computer program CAT has been developed and used to construct fault trees for two systems

Identification of expressed genes in cDNA library of hemocytes from the RLO-challenged oyster, Crassostrea ariakensis Gould with special functional implication of three complement-related fragments (CaC1q1, CaC1q2 and CaC3).

Science.gov (United States)

Xu, Ting; Xie, Jiasong; Li, Jianming; Luo, Ming; Ye, Shigen; Wu, Xinzhong

2012-06-01

A SMARTer™ cDNA library of hemocyte from Rickettsia-like organism (RLO) challenged oyster, Crassostrea ariakensis Gould was constructed. Random clones (400) were selected and single-pass sequenced, resulted in 200 unique sequences containing 96 known genes and 104 unknown genes. The 96 known genes were categorized into 11 groups based on their biological process. Furthermore, we identified and characterized three complement-related fragments (CaC1q1, CaC1q2 and CaC3). Tissue distribution analysis revealed that all of three fragments were ubiquitously expressed in all tissues studied including hemocyte, gills, mantle, digestive glands, gonads and adductor muscle, while the highest level was seen in the hemocyte. Temporal expression profile in the hemocyte monolayers reveled that the mRNA expression levels of three fragments presented huge increase after the RLO incubation at 3 h and 6 h in post-challenge, respectively. And the maximal expression levels at 3 h in post-challenge are about 256, 104 and 64 times higher than the values detected in the control of CaC1q1, CaC1q2 and CaC3, respectively. Copyright © 2012 Elsevier Ltd. All rights reserved.

A worksite prevention program for construction workers: Design of a randomized controlled trial

NARCIS (Netherlands)

Oude Hengel, K.M.; Joling, C.I.; Proper, K.I.; Blatter, B.M.; Bongers, P.M.

2010-01-01

Background. A worksite prevention program was developed to promote the work ability of construction workers and thereby prolong a healthy working life. The objective of this paper is to present the design of a randomized controlled trial evaluating the effectiveness of that intervention program

Vogtle Unit 1 readiness review: Assessment of Georgia Power Company readiness review pilot program

International Nuclear Information System (INIS)

Lewis, G.

1987-09-01

Georgia Power Company (GPC) performed a readiness review at Vogtle Unit 1 as a pilot program. The pilot program was a new and innovative approach for the systematic and disciplined review, with senior management involvement, of GPC's implementation of design, construction, and operational readiness processes. The program's principal objective was to increase the level of assurance that quality programs at Vogtle Unit 1 have been accomplished in accordance with regulatory requirements. This report assesses the effectiveness of the GPC's readiness review pilot program (RRPP) at Vogtle Unit 1. It includes (1) an overview of what was experienced during the program's implementation, (2) an assessment of how well program objectives were met, and (3) lessons learned on the future use of the readiness review concept. Overall, GPC and the NRC staff believe that the RRPP at Vogtle Unit 1 was a success and that the program provided significant added assurance that Vogtle Unit 1 licensing commitments and NRC regulations have been adequately implemented. Although altering the NRC licensing review process for the few plants still in the construction pipeline may not be appropriate, licensees may benefit significantly by performing readiness reviews on their own initiative as GPC did for Vogtle. (7 refs.)

Construction of a cDNA microarray derived from the ascidian Ciona intestinalis.

Science.gov (United States)

Azumi, Kaoru; Takahashi, Hiroki; Miki, Yasufumi; Fujie, Manabu; Usami, Takeshi; Ishikawa, Hisayoshi; Kitayama, Atsusi; Satou, Yutaka; Ueno, Naoto; Satoh, Nori

2003-10-01

A cDNA microarray was constructed from a basal chordate, the ascidian Ciona intestinalis. The draft genome of Ciona has been read and inferred to contain approximately 16,000 protein-coding genes, and cDNAs for transcripts of 13,464 genes have been characterized and compiled as the "Ciona intestinalis Gene Collection Release I". In the present study, we constructed a cDNA microarray of these 13,464 Ciona genes. A preliminary experiment with Cy3- and Cy5-labeled probes showed extensive differential gene expression between fertilized eggs and larvae. In addition, there was a good correlation between results obtained by the present microarray analysis and those from previous EST analyses. This first microarray of a large collection of Ciona intestinalis cDNA clones should facilitate the analysis of global gene expression and gene networks during the embryogenesis of basal chordates.

[Design for constructability studies in support of the DOE ALWR (Advanced Light Water Reactor) Program

International Nuclear Information System (INIS)

1990-03-01

An objective of this program was to influence two key areas: inputs to plant design that can enhance constructability; and improvements in the construction process. The investigations, workshops, meetings, and studies focused the program topics toward these areas. This document, Volume IV is Enchancing Constructability through design. The report is arranged to produce sections on major issues in each subject. At the end of each section are significant conclusions divided as: recommendations--conclusions worthy of acceptance; considerations--conclusions that were not universally accepted in the discussions but should be taken into account; and cautions--conclusions that should be evaluated to avoid past problems

Analytical representation of the thermal conductivity and electrical resistivity of UC/sub 1 +- x/, PuC/sub 1-x/, and (U/sub y/Pu/sub 1-y/)C/sub 1 +- x/

International Nuclear Information System (INIS)

Storms, E.K.

1982-12-01

This report uses selected measurements from the literature to construct analytical expressions that describe the electrical and thermal conductivity of pure, high-density UC/sub 1 +- x/, PuC/sub 1-x/, and (U/sub y/Pu/sub 1-y/C/sub 1 +- x/ as a function of x,y, and temperature. The approach shows that many of the differences between the reported measurements can be resolved if the carbon cntent of the single-phase material is taken into account. Analytical expressions are also given that describe the temperature variation of the phase boundaries for these phases. 16 figures

PCR-based cDNA library construction: general cDNA libraries at the level of a few cells.

OpenAIRE

Belyavsky, A; Vinogradova, T; Rajewsky, K

1989-01-01

A procedure for the construction of general cDNA libraries is described which is based on the amplification of total cDNA in vitro. The first cDNA strand is synthesized from total RNA using an oligo(dT)-containing primer. After oligo(dG) tailing the total cDNA is amplified by PCR using two primers complementary to oligo(dA) and oligo(dG) ends of the cDNA. For insertion of the cDNA into a vector a controlled trimming of the 3' ends of the cDNA by Klenow enzyme was used. Starting from 10 J558L ...

Construction of full-length cDNA library of white flower Salvia ...

African Journals Online (AJOL)

In order to screen and isolate secondary metabolite biosynthesis related gene, we construct a cDNA library of white flower Salvia miltiorrhiza bge. f.alba. High quality of total RNA was successfully isolated from roots of white flower S. miltiorrhiza using modified CTAB method. Double strand cDNA was cloned into pDNR-LIB ...

Hepatitis C virus nonstructural protein-5A activates sterol regulatory element-binding protein-1c through transcription factor Sp1

Energy Technology Data Exchange (ETDEWEB)

Xiang, Zhonghua; Qiao, Ling; Zhou, Yan [Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E3 (Canada); Babiuk, Lorne A. [University of Alberta, Edmonton, Alberta (Canada); Liu, Qiang, E-mail: qiang.liu@usask.ca [Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E3 (Canada)

2010-11-19

Research highlights: {yields} A chimeric subgenomic HCV replicon expresses HCV-3a NS5A in an HCV-1b backbone. {yields} HCV-3a NS5A increases mature SREBP-1c protein level. {yields} HCV-3a NS5A activates SREBP-1c transcription. {yields} Domain II of HCV-3a NS5A is more effective in SREBP-1c promoter activation. {yields} Transcription factor Sp1 is required for SREBP-1c activation by HCV-3a NS5A. -- Abstract: Steatosis is an important clinical manifestation of hepatitis C virus (HCV) infection. The molecular mechanisms of HCV-associated steatosis are not well understood. Sterol regulatory element-binding protein-1c (SREBP-1c) is a key transcription factor which activates the transcription of lipogenic genes. Here we showed that the nuclear, mature SREBP-1c level increases in the nucleus of replicon cells expressing HCV-3a nonstructural protein-5A (NS5A). We further showed that HCV-3a NS5A up-regulates SREBP-1c transcription. Additional analysis showed that transcriptional factor Sp1 is involved in SREBP-1c activation by HCV-3a NS5A because inhibition of Sp1 activity by mithramycin A or a dominant-negative Sp1 construct abrogated SREBP-1c promoter activation by HCV-3a NS5A. In addition, chromatin immunoprecipitation (ChIP) assay demonstrated enhanced binding of Sp1 on the SREBP-1c promoter in HCV-3a NS5A replicon cells. These results showed that HCV-3a NS5A activates SREBP-1c transcription through Sp1. Taken together, our results suggest that HCV-3a NS5A is a contributing factor for steatosis caused by HCV-3a infection.

Hepatitis C virus nonstructural protein-5A activates sterol regulatory element-binding protein-1c through transcription factor Sp1

International Nuclear Information System (INIS)

Xiang, Zhonghua; Qiao, Ling; Zhou, Yan; Babiuk, Lorne A.; Liu, Qiang

2010-01-01

Research highlights: → A chimeric subgenomic HCV replicon expresses HCV-3a NS5A in an HCV-1b backbone. → HCV-3a NS5A increases mature SREBP-1c protein level. → HCV-3a NS5A activates SREBP-1c transcription. → Domain II of HCV-3a NS5A is more effective in SREBP-1c promoter activation. → Transcription factor Sp1 is required for SREBP-1c activation by HCV-3a NS5A. -- Abstract: Steatosis is an important clinical manifestation of hepatitis C virus (HCV) infection. The molecular mechanisms of HCV-associated steatosis are not well understood. Sterol regulatory element-binding protein-1c (SREBP-1c) is a key transcription factor which activates the transcription of lipogenic genes. Here we showed that the nuclear, mature SREBP-1c level increases in the nucleus of replicon cells expressing HCV-3a nonstructural protein-5A (NS5A). We further showed that HCV-3a NS5A up-regulates SREBP-1c transcription. Additional analysis showed that transcriptional factor Sp1 is involved in SREBP-1c activation by HCV-3a NS5A because inhibition of Sp1 activity by mithramycin A or a dominant-negative Sp1 construct abrogated SREBP-1c promoter activation by HCV-3a NS5A. In addition, chromatin immunoprecipitation (ChIP) assay demonstrated enhanced binding of Sp1 on the SREBP-1c promoter in HCV-3a NS5A replicon cells. These results showed that HCV-3a NS5A activates SREBP-1c transcription through Sp1. Taken together, our results suggest that HCV-3a NS5A is a contributing factor for steatosis caused by HCV-3a infection.

Duct Remediation Program: Engineered access research and construction

International Nuclear Information System (INIS)

Beckman, T.D.; Davis, M.M.; Karas, T.M.

1992-01-01

The Rocky Flats Plant, Duct Remediation mission concentrated on removing Plutonium Oxide from the process ductwork in the primary Plutonium processing facility. When possible, remediation took place from existing process gloveboxes. Fifteen locations were identified, however, that required accessing duct runs where no process gloveboxes existed. The building's second floor utility areas had many locations where long, inaccessible duct runs were prevalent. Consequently, an extensive program for design, procurement and construction was initiated to contain and isolate ducts for penetration when existing glovebox sites were not present

ABSTRACT IMPLEMENTATION OF A KIND TO MANAGE DATA SETS USING PROGRAMMING LANGUAGE C + +

OpenAIRE

Ruiz L., Edgar; Hinojosa L., Hilmar

2014-01-01

This article presents the implementation of a data abstract type to represent the Set Theory Mathematical Concept, The program has been written in C++ Program Language applying the Object Oriented Programming Paradigm through a Dev C++ v.4.1 Compiler, a GNU compiler with GPL licence. El artículo presenta la implementación de un tipo abstracto de datos para representar el concepto matemático de la teoría de conjuntos. El programa ha sido escrito en lenguaje de programación C++ aplicando el ...

Constructive conflict coverage - A social-psychological research and development program

Directory of Open Access Journals (Sweden)

Wilhelm Kempf

2003-10-01

Full Text Available Peace journalism is a relatively new research area in psychology which emerged in the last decade of the last century. Building on findings from social psychology (group processes, social influence, conflict research, attitude change, propaganda, and enemy concept research and on models of conflict management and the constructive transformation of conflicts, an investigation is made of the factors that determine the escalation oriented bias of conventional war reporting, and of how this can be transformed into de-escalation and/or peace oriented conflict reporting. This paper provides an outline of this research and development program in six sections: (1 Interest Perception, (2 Task Formulation, (3 Basic Theoretical Assumptions, (4 War Discourse vs. Peace Discourse, (5 a Two Step Model, and (6 Journalist Training.

Practical C++ programming

National Research Council Canada - National Science Library

Oualline, Steve

2003-01-01

... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xv Part I. The Basics 1. What Is C++? A Brief History of C++ C++ Organization How to Learn C++...

Community Building Services Training Program: A Model Training Program to Provide Technical Training for Minority Adults in Construction, Building Maintenance,and Property Management. Final Report.

Science.gov (United States)

Community Building Maintenance Corp., Chicago, IL.

A demonstration program, administered by a community based building maintenance, management, and construction corporation, was developed to provide technical training for minority adults in construction, building maintenance, and property management in the Chicago area. The program was concerned with seeking solutions to the lack of housing, job…

Construction quality assurance program plan for the WIPP project, Carlsbad, NM

International Nuclear Information System (INIS)

1987-05-01

The purpose of this plan is to describe the Quality Assurance (QA) Program to be established and implemented by the US Department of Energy (DOE) Waste Isolation Pilot Plant (WIPP) Project Office (WPO) and by the Major Project Participants: the Architect-Engineer (Bechtel), the Construction Manager (US Army Corps of Engineers), the Scientific Advisor (Sandia National Laboratory), and the Management and Operating Contractor (Westinghouse Electric Corporation). This plan addresses the construction, including site evaluation, design, and turnover phases of WIPP. Other work in progress during the same period is controlled by DOE documents applicable to that work effort. The prime responsibility for ensuring the quality of construction rests with the DOE WIPP Project Office and is implemented through the combined efforts of the Construction Manager, the Construction Contractors, the Management and Operating Contractor, and the Architect-Engineer. Inspection and burden of proof of acceptability rests with the Construction Contractor as defined by the technical provisions of the contract and as otherwise specified by the DOE WIPP Project Office on an individual work-package basis. To the maximum extent possible, acceptance of work will be based upon first-hand witnessing by the Construction Manager and other representatives of the DOE organization

C Versus Fortran-77 for Scientific Programming

Directory of Open Access Journals (Sweden)

Tom MacDonald

1992-01-01

Full Text Available The predominant programming language for numeric and scientific applications is Fortran-77 and supercomputers are primarily used to run large-scale numeric and scientific applications. Standard C* is not widely used for numerical and scientific programming, yet Standard C provides many desirable linguistic features not present in Fortran-77. Furthermore, the existence of a standard library and preprocessor eliminates the worst portability problems. A comparison of Standard C and Fortran-77 shows several key deficiencies in C that reduce its ability to adequately solve some numerical problems. Some of these problems have already been addressed by the C standard but others remain. Standard C with a few extensions and modifications could be suitable for all numerical applications and could become more popular in supercomputing environments.

C.A.R. insurance and its significance in the construction of power plants

International Nuclear Information System (INIS)

Friedrich, J.

1975-01-01

The construction of a power lant entails a multitude of risks for the operator and for all parties participating in the construction. The progress of construction technology, reduced manufacturing times and new construction materials and methods result in greater risks. As a property insurance, C.A.R. insurance covers unforeseen destruction of or damage to the construction works from commencement of construction until handling over. It is thereby irrelevant whether such loss or damage falls to the burden of the principal or the contractors and craftsmen. In the event of loss or damage occurring, the search for those responsible is thus eliminated. Rectification of the loss or damage and continuation of the work is not delayed. (orig.) [de

Swift vs. Objective-C: A New Programming Language

Directory of Open Access Journals (Sweden)

Cristian González García

2015-06-01

In this article, we compare the new programming language of Apple, Swift, with the main programming language of Apple before Swift, Objective-C. We are going to show the differences, characteristics and novelties to verify the words of Apple about Swift. With that we want to answer the next question: Is Swift a new programming language easier, more secure and quicker to develop than Objective-C?

Economic evaluation of screening programs for hepatitis C virus infection: evidence from literature

Directory of Open Access Journals (Sweden)

Coretti S

2015-04-01

Full Text Available Silvia Coretti,1 Federica Romano,1 Valentina Orlando,2 Paola Codella,1 Sabrina Prete,1 Eugenio Di Brino,1 Matteo Ruggeri1 1Post-Graduate School of Economics and Management (ALTEMS, Università Cattolica del Sacro Cuore, Rome, Italy; 2Center of Pharmacoeconomics (CIRFF, Department of Pharmacy, Federico II University, Naples, Italy Background: Hepatitis C is a liver infection caused by hepatitis C virus. Its main complications are cirrhosis and liver cancer. According to the World Health Organization (WHO, more than 185 million people worldwide are infected with hepatitis C virus and, of these, 350,000 die every year. Due to the high disease prevalence and the existence of effective (and expensive medical treatments able to dramatically change the prognosis, early detection programs can potentially prevent the development of serious chronic conditions, improve health, and save resources. Objective: To summarize the available evidence on the cost-effectiveness of screening programs for hepatitis C. Methods: A literature search was performed on PubMed and Scopus search engines. Trip database was queried to identify reports produced by the major Health Technology Assessment (HTA agencies. Three reviewers dealt with study selection and data extraction blindly. Results: Ten papers eventually met the inclusion criteria. In studies focusing on asymptomatic cohorts of individuals at general risk the cost/quality adjusted life year of screening programs ranged between US $4,200 and $50,000/quality adjusted life year gained, while in those focusing on specific risk factors the incremental cost-effectiveness ratio ranged between $848 and $128,424/quality adjusted life year gained. Age of the target population and disease prevalence were the main cost-effectiveness drivers. Conclusion: Our results suggest that, especially in the long run, screening programs represent a cost-effective strategy for the management of hepatitis C. Keywords: hepatitis C, screening

[Construction of cTnC-linker-TnI (P) Genes, Expression of Fusion Protein and Preparation of Lyophilized Protein].

Science.gov (United States)

Song, Xiaoli; Liu, Xiaoyun; Cai, Lei; Wu, Jianwei; Wang, Jihua

2015-12-01

In order to construct and express human cardiac troponin C-linker-troponin I(P) [ cTnC-linker-TnI(P)] fusion protein, detect its activity and prepare lyophilized protein, we searched the CDs of human cTnC and cTnI from GenBank, synthesized cTnC and cTnI(30-110aa) into cloning vector by a short DNA sequence coding for 15 neutral amino acid residues. pCold I-cTnC-linker-TnI(P) was constructed and transformed into E. coli BL21(DE3). Then, cTnC-linker-TnI(P) fusion protein was induced by isopropyl-β-D-thiogalactopyranoside (IPTG). Soluable expression of cTnC-linker-TnI(P) in prokaryotic system was successfully obtained. The fusion protein was purified by Ni²⁺ Sepharose 6 Fast Flow affinity chromatography with over 95% purity and prepared into lyophilized protein. The activity of purified cTnC-linker-TnI(P) and its lyophilized protein were detected by Wondfo Finecare™ cTnI Test. Lyophilized protein of cTnC-linker-TnI(P) was stable for 10 or more days at 37 °C and 4 or more months at 25 °C and 4 °C. The expression system established in this research is feasible and efficient. Lyophilized protein is stable enough to be provided as biological raw materials for further research.

C++QEDv2 Milestone 10: A C++/Python application-programming framework for simulating open quantum dynamics

Science.gov (United States)

Sandner, Raimar; Vukics, András

2014-09-01

The v2 Milestone 10 release of C++QED is primarily a feature release, which also corrects some problems of the previous release, especially as regards the build system. The adoption of C++11 features has led to many simplifications in the codebase. A full doxygen-based API manual [1] is now provided together with updated user guides. A largely automated, versatile new testsuite directed both towards computational and physics features allows for quickly spotting arising errors. The states of trajectories are now savable and recoverable with full binary precision, allowing for trajectory continuation regardless of evolution method (single/ensemble Monte Carlo wave-function or Master equation trajectory). As the main new feature, the framework now presents Python bindings to the highest-level programming interface, so that actual simulations for given composite quantum systems can now be performed from Python. Catalogue identifier: AELU_v2_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AELU_v2_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: yes No. of lines in distributed program, including test data, etc.: 492422 No. of bytes in distributed program, including test data, etc.: 8070987 Distribution format: tar.gz Programming language: C++/Python. Computer: i386-i686, x86 64. Operating system: In principle cross-platform, as yet tested only on UNIX-like systems (including Mac OS X). RAM: The framework itself takes about 60MB, which is fully shared. The additional memory taken by the program which defines the actual physical system (script) is typically less than 1MB. The memory storing the actual data scales with the system dimension for state-vector manipulations, and the square of the dimension for density-operator manipulations. This might easily be GBs, and often the memory of the machine limits the size of the simulated system. Classification: 4.3, 4.13, 6.2. External routines: Boost C

Selective classification and quantification model of C&D waste from material resources consumed in residential building construction.

Science.gov (United States)

Mercader-Moyano, Pilar; Ramírez-de-Arellano-Agudo, Antonio

2013-05-01

The unfortunate economic situation involving Spain and the European Union is, among other factors, the result of intensive construction activity over recent years. The excessive consumption of natural resources, together with the impact caused by the uncontrolled dumping of untreated C&D waste in illegal landfills have caused environmental pollution and a deterioration of the landscape. The objective of this research was to generate a selective classification and quantification model of C&D waste based on the material resources consumed in the construction of residential buildings, either new or renovated, namely the Conventional Constructive Model (CCM). A practical example carried out on ten residential buildings in Seville, Spain, enabled the identification and quantification of the C&D waste generated in their construction and the origin of the waste, in terms of the building material from which it originated and its impact for every m(2) constructed. This model enables other researchers to establish comparisons between the various improvements proposed for the minimization of the environmental impact produced by building a CCM, new corrective measures to be proposed in future policies that regulate the production and management of C&D waste generated in construction from the design stage to the completion of the construction process, and the establishment of sustainable management for C&D waste and for the selection of materials for the construction on projected or renovated buildings.

Development and implementation of a construction environmental protection program at a solid radioactive waste management facility

Energy Technology Data Exchange (ETDEWEB)

Wong, T.S. [Atomic Energy of Canada Limited, Mississauga, Ontario (Canada); Bishop, T. [Atomic Energy of Canada Limited, Saint John, New Brunswick (Canada); Hickman, C.N. [Point Lepreau Generating Station, Saint John, New Brunswick (Canada)

2007-07-01

Refurbishment of ageing nuclear stations has great economic and environmental benefits, including reduced greenhouse gas emissions. The Government of New Brunswick (NB) decided in 2005 to refurbish the Point Lepreau Generating Station with Atomic Energy of Canada Limited (AECL) as the general contractor. The project includes construction of additional radioactive waste management facilities. AECL developed, for the construction project, an environmental protection program to comply with commitments made during the environmental assessment process, and regulatory requirements. The program covers detailed environmental plans, training courses, and engagement of consultants to provide training and conduct monitoring of the construction activities. Construction related environmental effects have been successfully mitigated and the monitoring results indicate compliance with all environmental requirements. (author)

Experience in Using Russian Program Complex «APM Winmachine» for Computing Local Strength of the Umbilical Mast Bearing Construction in the SR “Soyuz-2.1B"

Directory of Open Access Journals (Sweden)

V. A. Zverev

2015-01-01

Full Text Available The research concerns the computational analyses of local strength of the umbilical mast (UM, which is designed for the prelaunch preparation and launch security of the space rocket (SR "SOYUZ-2" of 1B stage.Based on the finite elements method, modeling and calculation of local strength for the most loaded UM elements are conducted using Russian program complex «APM WINMACHINE». The paper gives a justification for choosing the program complex «APM WINMACHINE, as a program calculation device.In calculating the principles of a local analysis are used. Physical models of the UM particular constructive units are formed to observe them under certain boundary conditions: forces and movements. Parameters of boundary conditions are determined in terms of stress-strain condition of UM simplified model as a whole.As the research results, the paper presents the finite element models of two UM constructive units, namely a joint of the mast farm branches with strengthening of the mast rotating part and an element in the UM bottom rotating part (“the spine”. Besides, there are also the calculated results of the local strength of abovementioned UM rotating part units: a general pattern of the stress distribution with stress values exceeding the allowable ones.The research results allow us to draw conclusions that the units under consideration have performance capability and require their constructive strengthening.The UM developers have taken in consideration recommendations, based on the UM rotating part local strength calculation, making appropriate correction in the project documentation. The experience gained in using the «APM WINMACHINE» allowed us to support the conclusion that it is efficient to solve the tasks of defining stress-strain condition of complicated spatial constructions.

45 CFR 1170.33 - New construction.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false New construction. 1170.33 Section 1170.33 Public... ASSISTED PROGRAMS OR ACTIVITIES Accessibility § 1170.33 New construction. (a) Design, construction, and... Federal Accessibility Standards. (1) Effective as of January 18, 1991, design, construction, or alteration...

26 CFR 148.1-5 - Constructive sale price.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 17 2010-04-01 2010-04-01 false Constructive sale price. 148.1-5 Section 148.1... § 148.1-5 Constructive sale price. (a) Purpose of this section. The purpose of this section is to set forth temporary rules to be used in determining a constructive sale price under section 4216(b) of the...

Alcohol binding in the C1 (C1A + C1B) domain of protein kinase C epsilon

Science.gov (United States)

Pany, Satyabrata; Das, Joydip

2015-01-01

Background Alcohol regulates the expression and function of protein kinase C epsilon (PKCε). In a previous study we identified an alcohol binding site in the C1B, one of the twin C1 subdomains of PKCε. Methods In this study, we investigated alcohol binding in the entire C1 domain (combined C1A and C1B) of PKCε. Fluorescent phorbol ester, SAPD and fluorescent diacylglycerol (DAG) analog, dansyl-DAG were used to study the effect of ethanol, butanol, and octanol on the ligand binding using fluorescence resonance energy transfer (FRET). To identify alcohol binding site(s), PKCεC1 was photolabeled with 3-azibutanol and 3-azioctanol, and analyzed by mass spectrometry. The effects of alcohols and the azialcohols on PKCε were studied in NG108-15 cells. Results In the presence of alcohol, SAPD and dansyl-DAG showed different extent of FRET, indicating differential effects of alcohol on the C1A and C1B subdomains. Effects of alcohols and azialcohols on PKCε in NG108-15 cells were comparable. Azialcohols labeled Tyr-176 of C1A and Tyr-250 of C1B. Inspection of the model structure of PKCεC1 reveals that these residues are 40 Å apart from each other indicating that these residues form two different alcohol binding sites. Conclusions The present results provide evidence for the presence of multiple alcohol-binding sites on PKCε and underscore the importance of targeting this PKC isoform in developing alcohol antagonists. PMID:26210390

TaC Studios New Construction Test House

Energy Technology Data Exchange (ETDEWEB)

Butler, T. [NAHB Research Center Industry Partnership, Upper Marlboro, MD (United States); Curtis, O. [NAHB Research Center Industry Partnership, Upper Marlboro, MD (United States); Kim, E. [NAHB Research Center Industry Partnership, Upper Marlboro, MD (United States); Roberts, S. [NAHB Research Center Industry Partnership, Upper Marlboro, MD (United States); Stephenson, R. [NAHB Research Center Industry Partnership, Upper Marlboro, MD (United States)

2013-03-01

As part of the NAHB Research Center Industry Partnership, Southface partnered with TaC Studios, an Atlanta based architecture firm specializing in residential and light commercial design, on the construction of a new test home in Atlanta, GA, in the mixed humid climate zone. This home will serve as a model home for the builder partner and addresses Building America energy savings targets through the planning and implementation of a design package will serve as a basis of design for the builder partner’s future homes. As a BA test house, this home will be evaluated to detail whole house energy use, end use loads, and HVAC and hot water efficiency.

On the GKP and BS constructions of c-boundary

International Nuclear Information System (INIS)

Kuang Zhiquan; Liang Canbin.

1987-07-01

Two examples are presented in this paper, the first is unfavorable to the c-boundary construction given by Geroch, Kronheimer and Penrose but in favor of that given by Budic and Sachs, while the second plays an opposite role. The second example is also an example of a causally continuous spacetime with a ''really big gap'', contrary to what was believed in the literature. (author). 10 refs

Penalty model for delay of bidding section construction period in South-to-North Water Diversion Eastern Route Project from perspective of programs

Directory of Open Access Journals (Sweden)

Jing-chun Feng

2012-09-01

Full Text Available According to the multi-project and program management theory, this paper analyzes the program generation principle and establishes a program based on progress goals. On the basis of the present situation of calculation of penalty for delay of the bidding section construction period with the critical path method, we studied the effects of contractor-induced delay of the bidding section construction period in detail, including the effects on the construction period of the bidding section itself, the earliest start times of the next bidding section and other subsequent bidding sections, and the construction period of the program, and then constructed a penalty model for delay of the bidding section construction period from the perspective of programs. Using the penalty model, we conducted a practical analysis of penalty for delay of the construction period of the Baoying station program in the South-to-North Water Diversion Project. The model can help determine the amount of penalty for delay of the construction period in bidding sections scientifically and reasonably.

C-84 Selective Porphyrin Macrocycle with an Adaptable Cavity Constructed Through Alkyne Metathesis

Energy Technology Data Exchange (ETDEWEB)

Zhang, C. X.; Long, H.; Zhang, W.

2012-06-21

A bisporphyrin macrocycle was constructed from a porphyrin-based diyne monomer in one step through alkyne metathesis. The fullerene binding studies (C{sub 60}, C{sub 70} and C{sub 84}) showed the highest binding affinity of the macrocycle for C{sub 84}, which is in great contrast to its bisporphyrin four-armed cage analogue that showed the strongest binding with C{sub 70}.

Social marketing to plan a fall prevention program for Latino construction workers.

Science.gov (United States)

Menzel, Nancy N; Shrestha, Pramen P

2012-08-01

Latino construction workers experience disparities in occupational death and injury rates. The Occupational Safety and Health Administration funded a fall prevention training program at the University of Nevada, Las Vegas in response to sharp increases in fall-related accidents from 2005 to 2007. The grant's purpose was to improve fall protection for construction workers, with a focus on Latinos. This study assessed the effectiveness of social marketing for increasing fall prevention behaviors. A multi-disciplinary team used a social marketing approach to plan the program. We conducted same day class evaluations and follow-up interviews 8 weeks later. The classes met trainee needs as evidenced by class evaluations and increased safety behaviors. However, Spanish-speaking Latinos did not attend in the same proportion as their representation in the Las Vegas population. A social marketing approach to planning was helpful to customize the training to Latino worker needs. However, due to the limitations of behavior change strategies, future programs should target employers and their obligation to provide safer workplaces. Copyright © 2012 Wiley Periodicals, Inc.

[cDNA library construction from panicle meristem of finger millet].

Science.gov (United States)

Radchuk, V; Pirko, Ia V; Isaenkov, S V; Emets, A I; Blium, Ia B

2014-01-01

The protocol for production of full-size cDNA using SuperScript Full-Length cDNA Library Construction Kit II (Invitrogen) was tested and high quality cDNA library from meristematic tissue of finger millet panicle (Eleusine coracana (L.) Gaertn) was created. The titer of obtained cDNA library comprised 3.01 x 10(5) CFU/ml in avarage. In average the length of cDNA insertion consisted about 1070 base pairs, the effectivity of cDNA fragment insertions--99.5%. The selective sequencing of cDNA clones from created library was performed. The sequences of cDNA clones were identified with usage of BLAST-search. The results of cDNA library analysis and selective sequencing represents prove good functionality and full length character of inserted cDNA clones. Obtained cDNA library from meristematic tissue of finger millet panicle represents good and valuable source for isolation and identification of key genes regulating metabolism and meristematic development and for mining of new molecular markers to conduct out high quality genetic investigations and molecular breeding as well.

[A study on the construction, expression and immunosterility of Lagurus laguru zona pellucida 3 DNA vaccine pVAX1-sig-LTB-lZP3-C3d3].

Science.gov (United States)

Li, Chen-Chen; Yu, Ji-Yun; Jiang, Min; Tu, Yi-Xian; Ma, Xiao-Lin; Zhang, Fu-Chun

2011-09-01

To enhance the immunocontraceptive effect of Lagurus lagurus zona pellucida 3 DNA vaccine, and to achieve the prospect of application through the pVAX1-sig-LTB-lZP3-C3d3 different immunity pathway. Two adjuvant molecules were constructed into the recombinant plasmid pVAX1-sig-LTB-lZP3-C3d3 as DNA vaccine which contains Escherichia coli heat-labile enterotoxin B subunit and the molecular adjuvant 3 copies of C3d. The results of RT-PCR and western blot showed that the DNA vaccine was expressed in mRNA and protein level. The female C57BL/6 mice were immunized by three ways: intramuscular injection, intranasal or oral route.Antibody levels and types were detected by ELISA. ELISA results showed that recombinant plasmid pVAX1-sig-LTB-lZP3-C3d3 immunization induced specific IgG, IgA levels were significantly different comparing with control (Psig-LTB-lZP3-C3d3 can induce the specific immune response efficiently and enhance the immunocontraceptive effects.

34 CFR 76.662 - Construction.

Science.gov (United States)

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Construction. 76.662 Section 76.662 Education Office of... State and Its Subgrantees? Participation of Students Enrolled in Private Schools § 76.662 Construction. A subgrantee shall insure that program funds are not used for the construction of private school...

KINKFOLD—an AutoLISP program for construction of geological cross-sections using borehole image data

Science.gov (United States)

Özkaya, Sait Ismail

2002-04-01

KINKFOLD is an AutoLISP program designed to construct geological cross-sections from borehole image or dip meter logs. The program uses the kink-fold method for cross-section construction. Beds are folded around hinge lines as angle bisectors so that bedding thickness remains unchanged. KINKFOLD may be used to model a wide variety of parallel fold structures, including overturned and faulted folds, and folds truncated by unconformities. The program accepts data from vertical or inclined boreholes. The KINKFOLD program cannot be used to model fault drag, growth folds, inversion structures or disharmonic folds where the bed thickness changes either because of deformation or deposition. Faulted structures and similar folds can be modelled by KINKFOLD by omitting dip measurements within fault drag zones and near axial planes of similar folds.

27 CFR 555.207 - Construction of type 1 magazines.

Science.gov (United States)

2010-04-01

... constructed of, or covered with, a nonsparking material. (3) Wood frame wall construction. The exterior of... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Construction of type 1... Construction of type 1 magazines. A type 1 magazine is a permanent structure: a building, an igloo or “Army...

Construction of Fixed Rate Non-Binary WOM Codes Based on Integer Programming

Science.gov (United States)

Fujino, Yoju; Wadayama, Tadashi

In this paper, we propose a construction of non-binary WOM (Write-Once-Memory) codes for WOM storages such as flash memories. The WOM codes discussed in this paper are fixed rate WOM codes where messages in a fixed alphabet of size $M$ can be sequentially written in the WOM storage at least $t^*$-times. In this paper, a WOM storage is modeled by a state transition graph. The proposed construction has the following two features. First, it includes a systematic method to determine the encoding regions in the state transition graph. Second, the proposed construction includes a labeling method for states by using integer programming. Several novel WOM codes for $q$ level flash memories with 2 cells are constructed by the proposed construction. They achieve the worst numbers of writes $t^*$ that meet the known upper bound in many cases. In addition, we constructed fixed rate non-binary WOM codes with the capability to reduce ICI (inter cell interference) of flash cells. One of the advantages of the proposed construction is its flexibility. It can be applied to various storage devices, to various dimensions (i.e, number of cells), and various kind of additional constraints.

Dynamic Programming Approach for Construction of Association Rule Systems

KAUST Repository

Alsolami, Fawaz

2016-11-18

In the paper, an application of dynamic programming approach for optimization of association rules from the point of view of knowledge representation is considered. The association rule set is optimized in two stages, first for minimum cardinality and then for minimum length of rules. Experimental results present cardinality of the set of association rules constructed for information system and lower bound on minimum possible cardinality of rule set based on the information obtained during algorithm work as well as obtained results for length.

Dynamic Programming Approach for Construction of Association Rule Systems

KAUST Repository

Alsolami, Fawaz; Amin, Talha M.; Chikalov, Igor; Moshkov, Mikhail; Zielosko, Beata

2016-01-01

In the paper, an application of dynamic programming approach for optimization of association rules from the point of view of knowledge representation is considered. The association rule set is optimized in two stages, first for minimum cardinality and then for minimum length of rules. Experimental results present cardinality of the set of association rules constructed for information system and lower bound on minimum possible cardinality of rule set based on the information obtained during algorithm work as well as obtained results for length.

Human pro. cap alpha. 1)(I) collagen: cDNA sequence for the C-propeptide domain

Energy Technology Data Exchange (ETDEWEB)

Maekelae, J K; Raassina, M; Virta, A; Vuorio, E

1988-01-11

The authors have previously constructed a cDNA clone pHCAL1, covering most of the C-terminal propeptide domain of human pro..cap alpha..1(I) collagen mRNA,by inserting a 678 bp EcoRI-XhoI fragment of cDNA into pBR322. Since the XhoI/SalI ligation prevented removal of the insert, they used the same strategy to obtain a similar clone in pUC8. RNA was isolated from fetal calvarial bones. The cDNA was digested with EcoRI and XhoI and fractionated on a 1 % agarose gel. Fragments of 650-700 bp were cloned in pUC8 at the polylinker site, which now permits easy removal of the insert. The new clone was named pHCAL1U since the RNA was isolated from another individual. The approach outlined is useful for studies on individual variation which is important to recognize when searching for disease-related mutations in type I collagen.

The Pekin duck programmed death-ligand 1: cDNA cloning, genomic structure, molecular characterization and mRNA expression analysis.

Science.gov (United States)

Yao, Q; Fischer, K P; Tyrrell, D L; Gutfreund, K S

2015-04-01

Programmed death ligand-1 (PD-L1) plays an important role in the attenuation of adaptive immune responses in higher vertebrates. Here, we describe the identification of the Pekin duck PD-L1 orthologue (duPD-L1) and its gene structure. The duPD-L1 cDNA encodes a 311-amino acid protein that has an amino acid identity of 78% and 42% with chicken and human PD-L1, respectively. Mapping of the duPD-L1 cDNA with duck genomic sequences revealed an exonic structure of its coding sequence similar to those of other vertebrates but lacked a noncoding exon 1. Homology modelling of the duPD-L1 extracellular domain was compatible with the tandem IgV-like and IgC-like IgSF domain structure of human PD-L1 (PDB ID: 3BIS). Residues known to be important for receptor binding of human PD-L1 were mostly conserved in duPD-L1 within the N-terminus and the G sheet, and partially conserved within the F sheet but not within sheets C and C'. DuPD-L1 mRNA was constitutively expressed in all tissues examined with highest expression levels in lung and spleen and very low levels of expression in muscle, kidney and brain. Mitogen stimulation of duck peripheral blood mononuclear cells transiently increased duPD-L1 mRNA expression. Our observations demonstrate evolutionary conservation of the exonic structure of its coding sequence, the extracellular domain structure and residues implicated in receptor binding, but the role of the longer cytoplasmic tail in avian PD-L1 proteins remains to be determined. © 2014 John Wiley & Sons Ltd.

Construction and characterization of a cDNA library from human ...

African Journals Online (AJOL)

The tumor-suppressor gene p53 and its downstream genes consist of a complicated gene network, and the challenge to understand the network is to identify p53 downstream genes. In order to isolate and identify new p53 regulated genes, we constructed and characterized a normalized cDNA library from human brain ...

The Jefferson Lab Quality Assurance Program for the SNS Superconducting Linac Construction Project

International Nuclear Information System (INIS)

Joseph Ozelis

2003-01-01

As part of a multi-laboratory collaboration, Jefferson Lab is currently engaged in the fabrication, assembly, and testing of 23 cryomodules for the superconducting linac portion of the Spallation Neutron Source (SNS) being built at Oak Ridge National Laboratory. As with any large accelerator construction project, it is vitally important that these components be built in a cost effective and timely manner, and that they meet the stringent performance requirements dictated by the project specifications. A comprehensive Quality Assurance (QA) program designed to help accomplish these goals has been implemented as an inherent component of JLab's SNS construction effort. This QA program encompasses the traditional spectrum of component performance, from incoming parts inspection, raw materials testing, through to sub-assembly and finished article performance evaluation

TaC Studios New Construction Test House

Energy Technology Data Exchange (ETDEWEB)

Butler, T.; Curtis, O.; Kim, E.; Roberts, S.; Stephenson, R.

2013-03-01

As part of the NAHB Research Center Industry Partnership, Southface partnered with TaC Studios, an Atlanta based architecture firm specializing in residential and light commercial design, on the construction of a new test home in Atlanta, GA in the mixed humid climate zone. This home will serve as a model home for the builder partner and addresses Building America energy savings targets through the planning and implementation of a design package will serve as a basis of design for the builder partner's future homes. As a BA test house, this home will be evaluated to detail whole house energy use, end use loads, and HVAC and hot water efficiency.

A non-traditional multinational approach to construction inspection program

International Nuclear Information System (INIS)

Ram, Srinivasan; Smith, M.E.; Walker, T.F.

2007-01-01

The next generation of nuclear plants would be fabricated, constructed and licensed in markedly different ways than the present light water reactors. Non-traditional commercial nuclear industry suppliers, shipyards in Usa and international fabricators, would be a source to supply major components and subsystems. The codes of construction may vary depending upon the prevailing codes and standards used by the respective supplier. Such codes and standards need to be reconciled with the applicable regulations (e.g., 10 CFR 52). A Construction Inspection Program is an integral part of the Quality Assurance Measures required during the Construction Phase of the power plant. In order to achieve the stated cost and schedule goals of the new build plants, a nontraditional multi-national approach would be required. In lieu of the traditional approach of individual utility inspecting the quality of fabrication and construction, a multi-utility team approach is a method that will be discussed. Likewise, a multinational cooperative licensing approach is suggested taking advantage of inspectors of the regulatory authority where the component would be built. The multi-national approach proposed here is based on the principle of forming teaming agreements between the utilities, vendors and the regulators. For instance, rather than sending Country A's inspectors all over the world, inspectors of the regulator in Country B where a particular component is being fabricated would in fact be performing the required inspections for Country A's regulator. Similarly teaming arrangements could be set up between utilities and vendors in different countries. The required oversight for the utility or the vendor could be performed by their counterparts in the country where a particular item is being fabricated

Assertion checking environment (ACE) for formal verification of C programs

International Nuclear Information System (INIS)

Sharma, Babita; Dhodapkar, S.D.; Ramesh, S.

2003-01-01

In this paper we describe an Assertion Checking Environment (ACE) for compositional verification of programs, which are written in an industrially sponsored safe subset of C programming language called MISRA C [Guidelines for the Use of the C Language in Vehicle Based Software, 1998]. The theory is based on Hoare logic [Commun. ACM 12 (1969) 576] and the C programs are verified using static assertion checking technique. First the functional specifications of the program, captured in the form of pre- and post-conditions for each C function, are derived from the specifications. These pre- and post-conditions are then introduced as assertions (also called annotations or formal comments) in the program code. The assertions are then proved formally using ACE and theorem proving tool called Stanford Temporal Prover [The Stanford Temporal Prover User's Manual, 1998]. ACE has been developed by us and consists mainly of a translator c2spl, a GUI and some utility programs. The technique and tools developed are targeted towards verification of real-time embedded software

An exact bosonization rule for c = 1 noncritical string theory

International Nuclear Information System (INIS)

Ishibashi, Nobuyuki; Yamaguchi, Atsushi

2007-01-01

We construct a string field theory for c = 1 noncritical strings using the loop variables as the string field. We show how one can express the nonrelativistic free fermions which describes the theory, in terms of these string fields

1-Nitropyrene (1-NP) induces apoptosis and apparently a non-apoptotic programmed cell death (paraptosis) in Hepa1c1c7 cells

International Nuclear Information System (INIS)

Asare, Nana; Landvik, Nina E.; Lagadic-Gossmann, Dominique; Rissel, Mary; Tekpli, Xavier; Ask, Kjetil; Lag, Marit; Holme, Jorn A.

2008-01-01

Mechanistic studies of nitro-PAHs (polycyclic aromatic hydrocarbons) of interest might help elucidate which chemical characteristics are most important in eliciting toxic effects. 1-Nitropyrene (1-NP) is the predominant nitrated PAH emitted in diesel exhaust. 1-NP-exposed Hepa1c1c7 cells exhibited marked changes in cellular morphology, decreased proliferation and different forms of cell death. A dramatic increase in cytoplasmic vacuolization was observed already after 6 h of exposure and the cells started to round up at 12 h. The rate of cell proliferation was markedly reduced at 24 h and apoptotic as well as propidium iodide (PI)-positive cells appeared. Electron microscopic examination revealed that the vacuolization was partly due to mitochondria swelling. The caspase inhibitor Z-VAD-FMK inhibited only the apoptotic cell death and Nec-1 (an inhibitor of necroptosis) exhibited no inhibitory effects on either cell death or vacuolization. In contrast, cycloheximide markedly reduced both the number of apoptotic and PI-positive cells as well as the cytoplasmic vacuolization, suggesting that 1-NP induced paraptotic cell death. All the MAPKs; ERK1/2, p38 and JNK, appear to be involved in the death process since marked activation was observed upon 1-NP exposure, and their inhibitors partly reduced the induced cell death. The ERK1/2 inhibitor PD 98057 completely blocked the induced vacuolization, whereas the other MAPKs inhibitors only had minor effects on this process. These findings suggest that 1-NP may cause apoptosis and paraptosis. In contrast, the corresponding amine (1-aminopyrene) elicited only minor apoptotic and necrotic cell death, and cells with characteristics typical of paraptosis were absent

Synthesis of [2-13C, 2-14C] 2-aminoethanol, [1-13C, 1-14C] 2-chloroethylamine, N,N'-bis([1-13C, 1-14C] 2-chloroethyl)-N-nitrosourea(BCNU) and N-([1-13C, 1-14C] 2-chloroethyl)-N-nitrosourea(CNU)

International Nuclear Information System (INIS)

Narayan, R.; Chang, C-j.

1982-01-01

[2- 13 C, 2- 14 C]2-Aminoethanol hydrochloride was prepared in good yield from Na*CN in a two step sequence by first converting the Na*CN to OHCH 2 *CN and then reducing the nitrile directly with a solution of borane-tetrahydrofuran complex. The reaction procedure was simple and the pure product could be obtained readily. Using this specifically labelled precursor, the synthesis of [1- 13 C, 1- 14 C]2-chloroethylamine hydrochloride, N-([1- 13 C, 1- 14 C]2-chloroethyl)-N-nitrosourea(CNU) and N,N'-bis([1- 13 C, 1- 14 C]2-chloroethyl)-N-nitrosourea(BCNU) in good yield without isotope scrambling was also reported. (author)

Static Analysis of Lockless Microcontroller C Programs

Directory of Open Access Journals (Sweden)

Eva Beckschulze

2012-11-01

Full Text Available Concurrently accessing shared data without locking is usually a subject to race conditions resulting in inconsistent or corrupted data. However, there are programs operating correctly without locking by exploiting the atomicity of certain operations on a specific hardware. In this paper, we describe how to precisely analyze lockless microcontroller C programs with interrupts by taking the hardware architecture into account. We evaluate this technique in an octagon-based value range analysis using access-based localization to increase efficiency.

Construction and clinical application of complex utility programs in the SEGAMS-80 system

International Nuclear Information System (INIS)

Mate, E.; Csirik, J.; Csernay, L.; Makay, A.

1981-01-01

SEGAMS-80 is a system for processing isotope-diagnostic pictures easily and safely for physicians. The functions built into the system form a tree-structure. In certain stages of processing, tables completed according to the medical point of view show identification and a short description of the actual performable functions. The functions available allow an interactive performance of diagnostic processes for different purposes. Interactivity is undesirable while processing routine examinations, since the functions to be performed, their sequence and parameters could be identical in all cases. SEGAMS-80 makes it possible to construct complex programs, to put them into the system and execute them. During the complex program the desired functions are automatically executed. The operator's interference is needed only where the author of the complex program has stated that it is necessary from the medical aspects. Experience gained with several SEGAMS-80 systems has shown that they can be successfully used in isotope diagnostics, without requiring any training in computing techniques from the physicians. A schematic description is given of the structure of SEGAMS-80 together with a detailed account of how to construct complex utility programs. (author)

The role of cysteine residues in the sulphate transporter, SHST1: construction of a functional cysteine-less transporter.

Science.gov (United States)

Howitt, Susan M

2005-05-20

We investigated the role of cysteine residues in the sulphate transporter, SHST1, with the aim of generating a functional cysteine-less variant. SHST1 contains five cysteine residues and none was essential for function. However, replacement of C421 resulted in a reduction in transport activity. Sulphate transport by C205 mutants was dependent on the size of the residue at this position. Alanine at position 205 resulted in a complete loss of function whereas leucine resulted in a 3-fold increase in sulphate transport relative to wild type SHST1. C205 is located in a putative intracellular loop and our results suggest that this loop may be important for sulphate transport. By replacing C205 with leucine and the other four cysteine residues with alanine, we constructed a cysteine-less variant of SHST1 that has transport characteristics indistinguishable from wild type. This construct will be useful for further structure and function studies of SHST1.

Infectious genotype 1a, 1b, 2a, 2b, 3a, 5a, 6a and 7a hepatitis C virus lacking the hypervariable region 1 (HVR1)

DEFF Research Database (Denmark)

2014-01-01

.sub.1389c,A1590G (6a/2a) constructs for the deletion of Hypervariable Region 1 (HVR1) to construct viable, JFH 1 (genotype 2a) based, genomes. The present inventors serially passaged the viruses in cell culture obtaining relatively high HCV RNA titers and infectivity titers. Sequence analysis...... of the viruses identified mutations adapting H77/JFH 1.sub.T27OOC,A4O8OT,.DELTA.HVR1 (1a/2a), J8/JFH .sub.1.DELTA.HVR1 (2b/2a), S52/JFH 1.sub.T2718G,T716OC,.DELTA.HVR1 (3a/2a) and J4/JFH 1.sub.T2996C,A4827T,.DELTA.HVR1 (1b/2a) to the HVR1 deletion....

MATES in Construction: Impact of a Multimodal, Community-Based Program for Suicide Prevention in the Construction Industry

Directory of Open Access Journals (Sweden)

Graham Martin

2011-11-01

Full Text Available A large-scale workplace-based suicide prevention and early intervention program was delivered to over 9,000 construction workers on building sites across Queensland. Intervention components included universal General Awareness Training (GAT; general mental health with a focus on suicide prevention; gatekeeper training provided to construction worker volunteer ‘Connectors’; Suicide First Aid (ASIST training offered to key workers; outreach support provided by trained and supervised MIC staff; state-wide suicide prevention hotline; case management service; and postvention support provided in the event of a suicide. Findings from over 7,000 workers (April 2008 to November 2010 are reported, indicating strong construction industry support, with 67% building sites and employers approached agreeing to participate in MIC. GAT participants demonstrated significantly increased suicide prevention awareness compared with a comparison group. Connector training participants rated MIC as helpful and effective, felt prepared to intervene with a suicidal person, and knew where to seek help for a suicidal individual following the training. Workers engaged positively with the after-hours crisis support phone line and case management. MIC provided postvention support to 10 non-MIC sites and sites engaged with MIC, but not yet MIC-compliant. Current findings support the potential effectiveness and social validity of MIC for preventing suicide in construction workers.

MATES in Construction: Impact of a Multimodal, Community-Based Program for Suicide Prevention in the Construction Industry

Science.gov (United States)

Gullestrup, Jorgen; Lequertier, Belinda; Martin, Graham

2011-01-01

A large-scale workplace-based suicide prevention and early intervention program was delivered to over 9,000 construction workers on building sites across Queensland. Intervention components included universal General Awareness Training (GAT; general mental health with a focus on suicide prevention); gatekeeper training provided to construction worker volunteer ‘Connectors’; Suicide First Aid (ASIST) training offered to key workers; outreach support provided by trained and supervised MIC staff; state-wide suicide prevention hotline; case management service; and postvention support provided in the event of a suicide. Findings from over 7,000 workers (April 2008 to November 2010) are reported, indicating strong construction industry support, with 67% building sites and employers approached agreeing to participate in MIC. GAT participants demonstrated significantly increased suicide prevention awareness compared with a comparison group. Connector training participants rated MIC as helpful and effective, felt prepared to intervene with a suicidal person, and knew where to seek help for a suicidal individual following the training. Workers engaged positively with the after-hours crisis support phone line and case management. MIC provided postvention support to 10 non-MIC sites and sites engaged with MIC, but not yet MIC-compliant. Current findings support the potential effectiveness and social validity of MIC for preventing suicide in construction workers. PMID:22163201

Overexpression of the cAMP Receptor 1 in Growing Dictyostelium Cells

NARCIS (Netherlands)

Johnson, Ronald L.; Vaughan, Roxanne A.; Caterina, Michael J.; Haastert, Peter J.M. van; Devreotes, Peter N.

1991-01-01

cAR1, the cAMP receptor expressed normally during the early aggregation stage of the Dictyostelium developmental program, has been expressed during the growth stage, when only low amounts of endogenous receptors are present. Transformants expressing cAR1 have 7-40 times over growth stage and

Lace plant ethylene receptors, AmERS1a and AmERS1c, regulate ethylene-induced programmed cell death during leaf morphogenesis.

Science.gov (United States)

Rantong, Gaolathe; Evans, Rodger; Gunawardena, Arunika H L A N

2015-10-01

The lace plant, Aponogeton madagascariensis, is an aquatic monocot that forms perforations in its leaves as part of normal leaf development. Perforation formation occurs through developmentally regulated programmed cell death (PCD). The molecular basis of PCD regulation in the lace plant is unknown, however ethylene has been shown to play a significant role. In this study, we examined the role of ethylene receptors during perforation formation. We isolated three lace plant ethylene receptors AmERS1a, AmERS1b and AmERS1c. Using quantitative PCR, we examined their transcript levels at seven stages of leaf development. Through laser-capture microscopy, transcript levels were also determined in cells undergoing PCD and cells not undergoing PCD (NPCD cells). AmERS1a transcript levels were significantly lower in window stage leaves (in which perforation formation and PCD are occurring) as compared to all other leaf developmental stages. AmERS1a and AmERS1c (the most abundant among the three receptors) had the highest transcript levels in mature stage leaves, where PCD is not occurring. Their transcript levels decreased significantly during senescence-associated PCD. AmERS1c had significantly higher transcript levels in NPCD compared to PCD cells. Despite being significantly low in window stage leaves, AmERS1a transcripts were not differentially expressed between PCD and NPCD cells. The results suggested that ethylene receptors negatively regulate ethylene-controlled PCD in the lace plant. A combination of ethylene and receptor levels determines cell fate during perforation formation and leaf senescence. A new model for ethylene emission and receptor expression during lace plant perforation formation and senescence is proposed.

C in CS1: Snags and Viable Solution

Directory of Open Access Journals (Sweden)

Shumail Naveed

2018-01-01

Full Text Available Programming is one of the career rewarding skills; however, learning programming skill is extremely hard and arduous as supported by several studies. The first programming language has an everlasting impact on the programmer’s program’s development abilities. In most of the universities the imperative paradigm is used for introductory programming courses and generally C language is used as a base language of a first programming course. The C language is a leading programming language and extensively utilized for commercial applications. The majority of the programming languages are highly motivated from the C language, yet its intrinsic complexities and non-pedagogic origin evidently makes it hard and a complex choice for a first programming course. This paper proposed a rational and realizable solution that can make a C language a suitable choice for a first the course of programming.

C in CS1: Snags and viable solution

International Nuclear Information System (INIS)

Naveed, S.; Sarim, M.; Nadeem, A.

2018-01-01

Programming is one of the career rewarding skills; however, learning programming skill is extremely hard and arduous as supported by several studies. The first programming language has an everlasting impact on the programmer’s program’s development abilities. In most of the universities the imperative paradigm is used for introductory programming courses and generally C language is used as a base language of a first programming course. The C language is a leading programming language and extensively utilized for commercial applications. The majority of the programming languages are highly motivated from the C language, yet its intrinsic complexities and non-pedagogic origin evidently makes it hard and a complex choice for a first programming course. This paper proposed a rational and realizable solution that can make a C language a suitable choice for a first the course of programming. (author)

Construction and performance of two multicell Cherenkov counters used in FRAMM-NA1 spectrometer

International Nuclear Information System (INIS)

Amendolia, S.R.; Batignani, G.; Bedeschi, F.; Bertolucci, E.; Bettoni, D.; Bosisio, L.; Bottigli, U.; Bradaschia, C.; Budinich, M.; Dell'Orso, M.; Fidecaro, F.; Foa, L.; Focardi, E.; Giazotto, A.; Giorgi, M.A.; Liello, F.; Marrocchesi, P.S.; Mensa, A.; Menzione, A.; Ristori, L.; Rolandi, L.; Scribano, A.; Stanga, R.; Stefanini, A.; Tonelli, G.

1983-01-01

Two small dimension multicell Cherenkov counters have been built for FRAMM-NA1 multiparticle spectrometer to identify pions and kaons in the momentum range between 5 and 22 GeV/c. The performances achieved and the construction details are reported. (orig.)

Compiling the parallel programming language NestStep to the CELL processor

OpenAIRE

Holm, Magnus

2010-01-01

The goal of this project is to create a source-to-source compiler which will translate NestStep code to C code. The compiler's job is to replace NestStep constructs with a series of function calls to the NestStep runtime system. NestStep is a parallel programming language extension based on the BSP model. It adds constructs for parallel programming on top of an imperative programming language. For this project, only constructs extending the C language are relevant. The output code will compil...

Project W-320, 241-C-106 sluicing: Construction specification W-320-C1

International Nuclear Information System (INIS)

Bailey, J.W.

1998-01-01

Project W-320, Waste Retrieval Sluicing System (WRSS), specification is for procurement, fabrication and installation of equipment at the C Tank Farm, including Operator Station and some equipment just outside the C Tank Farm fence, necessary to support the sluicing operation. Work consists of furnishing labor, equipment, and materials to provide the means to procure materials and equipment, fabricate items, excavate and place concrete, and install equipment, piping, wiring, and structures in accordance with the Contract Documents. Major work elements include: Excavation for process and fire protection piping, electrical conduit trenches, and foundations for small structures; Placement of concrete cover blocks, foundations, and equipment pads; Procurement and installation of double walled piping, electrical conduit, fire and raw water piping, chilled water piping, and electrical cable; Procurement and installation of above-ground ventilation system piping between the (HVAC) Process building and Tank C-106; Core drill existing concrete; Furnish and installation of electrical distribution equipment; Installation of the concrete foundation, and assembly installation of the two Seismic Shutdown Systems with Environmental Enclosures; Fabrication and installation of in-pit pipe jumpers, including related valves, instruments and wiring; and Installation of a vertical submersible pump, horizontal booster pump, and winch assembly into tank access riser pits

Phase Transition Enthalpy Measurements of Organic and Organometallic Compounds. Sublimation, Vaporization and Fusion Enthalpies From 1880 to 2015. Part 1. C1 - C10

Science.gov (United States)

Acree, William; Chickos, James S.

2016-09-01

A compendium of phase change enthalpies published in 2010 is updated to include the period 1880-2015. Phase change enthalpies including fusion, vaporization, and sublimation enthalpies are included for organic, organometallic, and a few inorganic compounds. Part 1 of this compendium includes organic compounds from C1 to C10. Part 2 of this compendium, to be published separately, will include organic and organometallic compounds from C11 to C192. Sufficient data are presently available to permit thermodynamic cycles to be constructed as an independent means of evaluating the reliability of the data. Temperature adjustments of phase change enthalpies from the temperature of measurement to the standard reference temperature, T = 298.15 K, and a protocol for doing so are briefly discussed.

Synthesis of C3/C1-Substituted Tetrahydroisoquinolines

Directory of Open Access Journals (Sweden)

Mohamed Mihoubi

2015-08-01

Full Text Available A broad biological screening of the natural alkaloid N-methylisosalsoline (2 extracted from Hammada scoparia leaves against a panel of human and parasitic proteases revealed an interesting activity profile of 2 towards human 20S proteasome. This outcome suggests that the 1,2,3,4-tetrahydroisoquinoline skeleton may be exploited as a template for the development of novel anticancer agents. In this article, we report the synthesis and chemical characterization of a new series of isosalsoline-type alkaloids (10–11 with variations at N2 and C3 positions with respect to the natural Compound 2, obtained by a synthetic strategy that involves the Bischler-Napieralski cyclization. The substrate for the condensation to the tetrahydroisoquinoline system, i.e., a functionalized β-arylethyl amine, was obtained through an original double reduction of nitroalkene. The synthetic strategy can be directed to the construction of highly substituted and functionalized 1,2,3,4-tetrahydroisoquinolines.

AUTOMATA PROGRAMS CONSTRUCTION FROM SPECIFICATION WITH AN ANT COLONY OPTIMIZATION ALGORITHM BASED ON MUTATION GRAPH

Directory of Open Access Journals (Sweden)

Daniil S. Chivilikhin

2014-11-01

Full Text Available The procedure of testing traditionally used in software engineering cannot guarantee program correctness; therefore verification is used at the excess requirements to programs reliability. Verification makes it possible to check certain properties of programs in all possible computational states; however, this process is very complex. In the model checking method a model of the program is built (often, manually and requirements in terms of temporal logic are formulated. Such temporal properties of the model can be checked automatically. The main issue in this framework is the gap between the program and its model. Automata-based programming paradigm gives the possibility to overcome this limitation. In this paradigm, program logic is represented using finite-state machines. The advantage of finite-state machines is that their models can be constructed automatically. The paper deals with the application of mutation-based ant colony optimization algorithm to the problem of finite-state machine construction from their specification, defined by test scenarios and temporal properties. The presented approach has been tested on the elevator doors control problem as well as on randomly generated data. Obtained results show the ant colony algorithm is two-three times faster than the previously used genetic algorithm. The proposed approach can be recommended for inferring control programs for critical systems.

C.E.C. program on radioactive waste management disposal and risk assessment

International Nuclear Information System (INIS)

Orlowski, S.; Girardi, F.; Bresesti, M.

1976-01-01

The Commission of the European Communities (CEC) has been involved many years with the radioactive waste problem; but a major effort started in 1973 when a specific program was given to the Commission's own laboratories (C.E.C. Joint Research Center, Ispra Establishment). This effort is very much enlarged since June 1975, when the Commission was authorized to start a coordinated program with the national laboratories of the nine member states, financed on a 50/50 basis. The contribution of the Commission for the 1975-79 plan amounts to $19 million. The overall program now involves several laboratories and does represent a significant European effort to contribute to solving a world scale problem; it is intended to promote a large international cooperation

Power Grid Construction Project Portfolio Optimization Based on Bi-level programming model

Science.gov (United States)

Zhao, Erdong; Li, Shangqi

2017-08-01

As the main body of power grid operation, county-level power supply enterprises undertake an important emission to guarantee the security of power grid operation and safeguard social power using order. The optimization of grid construction projects has been a key issue of power supply capacity and service level of grid enterprises. According to the actual situation of power grid construction project optimization of county-level power enterprises, on the basis of qualitative analysis of the projects, this paper builds a Bi-level programming model based on quantitative analysis. The upper layer of the model is the target restriction of the optimal portfolio; the lower layer of the model is enterprises’ financial restrictions on the size of the enterprise project portfolio. Finally, using a real example to illustrate operation proceeding and the optimization result of the model. Through qualitative analysis and quantitative analysis, the bi-level programming model improves the accuracy and normative standardization of power grid enterprises projects.

Orbifold constructions and the classification of self-dual c=24 conformal field theories

International Nuclear Information System (INIS)

Montague, P.S.

1994-01-01

We discuss questions arising from the work of Schellekens [A.N. Schellekens, Phys. Lett. B 277 (1992) 277; Meromorphic c=24 conformal field theories, CERN-TH.6478/92, 1992.] After introducing the concept of complementary representations, we examine Z 2 -orbifold constructions in general, and propose a technique for identifying the orbifold theory without knowledge of its explicit construction. This technique is then generalised to twists of order 3, 5 and 7, and we proceed to apply our considerations to the FKS constructions H (Λ) (Λ an even self-dual lattice) and the reflection-twisted orbifold theories and H ;(Λ), which together remain the only c=24 theories which have so far been proven to exist [L. Dolan, P. Goddard and P. Montague, Nucl. Phys. B 338 (1990) 529.] We also make, in the course of our arguments, some comments on the automorphism groups of the theories H (Λ) and and H ;(Λ), and of meromorphic theories in general, introducing the concept of deterministic theories. ((orig.))

Plan of development of ZrC-TRISO coated fuel particle and construction of ZrC coater

Energy Technology Data Exchange (ETDEWEB)

Ueta, Shohei; Ino, Hiroichi; Sawa, Kazuhiro [Japan Atomic Energy Research Inst., Oarai, Ibaraki (Japan). Oarai Research Establishment; Tobita, Tsutomu [Nuclear Engineering Company, Ltd., Tokai, Ibaraki (Japan); Takahashi, Masashi [Nuclear Fuel Industries, Ltd., Tokyo (Japan)

2002-11-01

In order to use coated fuel particle under higher temperature condition, more refractory coating material, which is more refractory than conventional silicon carbide (SiC), should be applied. Zirconium carbide (ZrC) is considered to be one of the promising materials, which is proposed as candidate for VHTR fuel material in GENERATION-IV, because of its intactness under high temperature of around 2000degC and its higher stability against kernel migration (amoeba effect) and fission product corrosion under normal operating condition. In order to develop ZrC coated particle for commercial use, research and development items were extracted based on review of the previous works. Research and development plan was determined. Based on the plan, a new ZrC coater of 100g batch size, which applies bromine process, was constructed. This report describes the review of precious works, extracted research and develop items and plan, and specifications of the ZrC coater. (author)

Construction of Six Coordination Polymers Based on a 5,5′-(1,2-Ethynyl)bis-1,3-benzenedicarboxylic Ligand: Synthesis, Structure, Gas Sorption, and Magnetic Properties

KAUST Repository

Zheng, Bing

2013-03-06

Six novel coordination polymers based on a multifunctional ligand, 5,5\\'-(1,2-ethynyl)bis-1,3-benzenedicarboxylic (H4EBDC), namely, |(C3H7NO)2(H2O)7(C 2H5OH)3| [Zn2(C18H 6O8)(C10H8N2) 2] (1), |(C3H7NO)3(H2O)30- (CH3CN)2|[Zn 6(C18H6O8)3(C 6H12N2O2)2] (2), |(C 3H7NO)2- (H2O)2(H 3O)2|[Cd3(C18H6O 8)2] (3), |(C3H7NO)|[Mn- (C 18H8O8)(C3H7NO) 2] (4), |(C3H7NO)2(H2O)(C 2H7N)3| [Mn6(C18H 7O8)4(H2O)8] (5), and [Mn2(C18H6O8)(C3H 7NO)2] (6), have been constructed under solvothermal conditions and structurally characterized by single-crystal X-ray diffraction. In these compounds, the ligand, H4EBDC, exhibits different coordination modes and conformations, constructing various architectures by bridging a variety of metal ions or polynuclear clusters. Compound 1 forms a three-dimensional (3D) FSC network constructed from two-dimensional (2D) layer motifs joined by EBDC4- and 4,4\\'-bipyridine bridges. Compound 2 possesses an NbO topology by linking Zn2(CO2)4 units with the ligand, coordinated amine molecules fill the pores, while compound 3 exhibits a 3D FLU network with Cd2+ as the cation and features an infinite framework built from tricadmium clusters. Compound 4 is based on PtS net, constructed of 4-connected rectangular H4EBDC units with tetrahedral monometallic Mn(CO2)4 nodes. Compound 5 is composed of 2D layers with (3,6)-connected KGD topology, and compound 6 consists of a 3D PtS-X network, built by bridging a metal chain with the ligand. The structures of these compounds have been discussed together with their corresponding properties, such as gas storage, separation, and magnetic properties. © 2013 American Chemical Society.

A new 1-2 GeV/c separated beam for BNL

Energy Technology Data Exchange (ETDEWEB)

Pile, P.H.; Beavis, D.; Brown, R.L.; Chrien, R.; Danby, G.; Jackson, J.; Lazarus, D.M.; Leonhardt, W.; Pearson, C.; Pendzick, A.; Montemurro, P.; Russo, T.; Sandberg, J.; Sawafta, R.; Spataro, C.; Walker, J. (Brookhaven National Lab. Associated Universities, Inc., Upton, NY (United States)); Enge, H.A. (Massachusetts Inst. of Tech., Cambridge, MA (United States))

1992-09-15

A 1-2 GeV/c beam line has been constructed at the Brookhaven National Laboratory alternating gradient synchrotron (BNL AGS). The beam line is optimized to deliver an intense clean beam of 1.8 GeV/c negative kaons for an H particle search experiment and incorporates two stages of velocity selection with the magnetic optics corrected to third order. Details of the beam line design as well as results of the commissioning will be discussed. (orig.).

[Effect of the Disease Management Program on HbA1c Value in Type 2 Diabetes Mellitus Patients: A Retrospective Comparison between Disease Management Programs and Standard Care].

Science.gov (United States)

Wiefarn, Stefan; Kostev, Karel; Heumann, Christian; Rettelbach, Anja

2017-10-01

Background  This retrospective study aims to measure the effect of the disease management program (DMP) for type 2 diabetes mellitus (T2DM) patients on HbA 1c value within Germany. Methods  This study is based on patient data from the Disease Analyzer panel (IMS Health). An adequate control group was created using 2:1 propensity score matching. After matching, the analysis included 14 759 patients. Of these, 5875 participated in a DMP while 8884 received standard care. The DMP effect was estimated on the basis of the matched data, using an unpaired t-test. In addition, subgroups were considered from the perspective of personalized medicine. Results  The reduction in HbA 1c values in the DMP group amounted to an average of 1.0 percentage point (baseline HbA 1c  = 8.1 vs. final HbA 1c  = 7.1), while the SC group was able to achieve an average reduction in HbA 1c values of 0.9 percentage point (baseline HbA 1c  = 8.1 vs. final HbA 1c  = 7.2). The DMP group thus achieved an average reduction in HbA 1c values that exceeded that of the SC group by only 0.1 percentage point (95 % CI: 0.04 - 0.16). Descriptively, it also became apparent that patients from the DMP group received a greater average number of annual prescriptions and had more HbA 1c measurements. The subgroup analysis identified groups of patients who benefit more from DMPs than others. Thus, young patients or patients who are being treated by diabetologists are able to benefit most from a DMP. Furthermore, the baseline HbA 1c value has an influence on the DMP effect. Conclusion  T2DM patients in the DMP exhibit a significantly higher reduction in HbA 1c value. However, it is questionable whether this effect is clinically relevant. Certain groups of patients benefit more from DMPs than others. Nevertheless, further studies are needed in order to better understand the impact of the DMP on HbA 1c value and the reasons for the subgroup effects. Such studies should be carried

46 CFR 58.05-1 - Material, design and construction.

Science.gov (United States)

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Material, design and construction. 58.05-1 Section 58.05... AUXILIARY MACHINERY AND RELATED SYSTEMS Main Propulsion Machinery § 58.05-1 Material, design and construction. (a) The material, design, construction, workmanship, and arrangement of main propulsion machinery...

Linear programming model to construct phylogenetic network for 16S rRNA sequences of photosynthetic organisms and influenza viruses.

Science.gov (United States)

Mathur, Rinku; Adlakha, Neeru

2014-06-01

Phylogenetic trees give the information about the vertical relationships of ancestors and descendants but phylogenetic networks are used to visualize the horizontal relationships among the different organisms. In order to predict reticulate events there is a need to construct phylogenetic networks. Here, a Linear Programming (LP) model has been developed for the construction of phylogenetic network. The model is validated by using data sets of chloroplast of 16S rRNA sequences of photosynthetic organisms and Influenza A/H5N1 viruses. Results obtained are in agreement with those obtained by earlier researchers.

Overexpression of the polycystin-1 (PC-1) C-tail enhances sensitivity of M-1 cells to ouabain

Science.gov (United States)

Jansson, Kyle; Magenheimer, Brenda S.; Maser, Robin L.; Calvet, James P.; Blanco, Gustavo

2014-01-01

Cells derived from renal cysts of patients with autosomal dominant polycystic kidney disease (ADPKD) are abnormally sensitive to ouabain, responding to physiological ouabain concentrations with enhanced proliferation and increased forskolin-induced transepithelial fluid secretion. This requires activation of the epidermal growth factor receptor (EGFR), Src kinase, and the extracellular regulated kinases MEK and ERK. Here, we have determined if the ADPKD phenotype obtained in mouse cortical collecting duct cells by stable overexpression of the C-terminal domain of polycystin-1 (PC-1 C-tail) also elicits the ADPKD-like response to ouabain in the cells. M-1 C20 cells expressing the PC-1 C-tail, and M-1 C17 cells, lacking expression of this construct, were treated with physiological concentrations of ouabain, and cell proliferation, activation of the EGFR-Src-MEK-ERK pathway, forskolin-induced transepithelial Cl− secretion, and the sensitivity of the Na,K-ATPase to ouabain were explored. M-1 C20 cells responded to ouabain with increased cell proliferation and ERK phosphorylation. Ouabain also augmented forskolin-induced and cystic fibrosis transmembrane conductance regulator (CFTR)-mediated apical secretion of Cl− in M-1 C20 cells. These effects required activation of EGFR, Src and MEK. In contrast, ouabain had no significant effects on M-1 C17 cells. Interestingly, approximately 20 % of the Na,K-ATPase from M-1 C20 cells presented an abnormally increased sensitivity to ouabain. Overexpression of PC-1 C-tail in M-1 C20 cells is associated with a ouabain sensitive phenotype and an increased ability of the cells to proliferate and secrete anions upon ouabain stimulation. This phenotype mimics the ouabain sensitivity of ADPKD cells and may help promote their cystogenic potential. PMID:23784065

The Abbott School Construction Program: NJ Department of Education Proposed Facilities Regulations. Analysis of Preschool Issues

Science.gov (United States)

Ponessa, Joan; Boylan, Ellen

2004-01-01

This report on preschool facilities analyzes regulations proposed by the New Jersey Department of Education (NJDOE) to implement the Educational Facilities Construction and Financing Act. (EFCFA). EFCFA, which authorizes and governs New Jersey's public school construction program, was enacted in July 2000 to implement the State Supreme Court's…

Quality assurance program requirements (design and construction). Task RS 002-5. Revision 3

International Nuclear Information System (INIS)

1985-08-01

This regulatory guide describes a method acceptable to the NRC staff for complying with regard to establishing and implementing the requisite quality assurance program for the design and construction of nuclear power plants. Guidance for the establishment and execution of quality assurance programs during operation and decommissioning of nuclear power plants have been or will be addressed in separate regulatory guides. Similarly, quality assurance provisions concerning fuel cycle facilities have been or will be addressed in separate regulatory guides

[Construction and identification of Nogo extra cellular peptide residues 1-40 gene lentiviral vector].

Science.gov (United States)

Yuan, Haifeng; Song, Yueming; Liu, Hao; Zhou, Chunguang; Kong, Qingquan; Liu, Liming; Gong, Quan

2012-02-01

To construct a lentiviral expression vector carrying Nogo extra cellular peptide residues 1-40 (NEP1-40) and to obtain NEP1-40 efficient and stable expression in mammalian cells. The DNA fragment of NEP1-40 coding sequence was amplified by PCR with designed primer from the cDNA library including NEP1-40 gene, and then subcloned into pGC-FU vector with in-fusion technique to generate the lentiviral expression vector, pGC-FU-NEP1-40. The positive clones were screened by PCR and the correct NEP1-40 was confirmed by sequencing. Recombinant lentiviruses were produced in 293T cells after the cotransfection of pGC-FU-NEP1-40, and packaging plasmids of pHelper 1.0 and pHelper 2.0. Green fluorescent protein (GFP) expression of infected 293T cells was observed to evaluate gene delivery efficiency. NEP1-40 protein expression in 293T cells was detected by Western blot. The lentiviral expression vector carrying NEP1-40 was successfully constructed by GFP observation, and NEP1-40 protein expression was detected in 293T cells by Western blot. The recombinant lentivirus pGC-FU-NEP1-40 is successfully constructed and it lays a foundation for further molecular function study of NEP 1-40.

Command Leadership DEOCS 4.1 Construct Validity Summary

Science.gov (United States)

2017-08-01

Command Leadership DEOCS 4.1 Construct Validity Summary DEFENSE EQUAL OPPORTUNITY MANAGEMENT INSTITUTE...Report #15-18 1 Command Leadership DEOCS 4.1 Construct Validity Summary Background In 2014, DEOMI released DEOCS 4.0 for Department of Defense...individual items on the DEOCS. The following paper details the work conducted to modify the factor of Leadership Cohesion so that it focuses more

A constructive Indian country response to the evidence-based program mandate.

Science.gov (United States)

Walker, R Dale; Bigelow, Douglas A

2011-01-01

Over the last 20 years governmental mandates for preferentially funding evidence-based "model" practices and programs has become doctrine in some legislative bodies, federal agencies, and state agencies. It was assumed that what works in small sample, controlled settings would work in all community settings, substantially improving safety, effectiveness, and value-for-money. The evidence-based "model" programs mandate has imposed immutable "core components," fidelity testing, alien programming and program developers, loss of familiar programs, and resource capacity requirements upon tribes, while infringing upon their tribal sovereignty and consultation rights. Tribal response in one state (Oregon) went through three phases: shock and rejection; proposing an alternative approach using criteria of cultural appropriateness, aspiring to evaluability; and adopting logic modeling. The state heard and accepted the argument that the tribal way of knowing is different and valid. Currently, a state-authorized tribal logic model and a review panel process are used to approve tribal best practices for state funding. This constructive response to the evidence-based program mandate elevates tribal practices in the funding and regulatory world, facilitates continuing quality improvement and evaluation, while ensuring that practices and programs remain based on local community context and culture. This article provides details of a model that could well serve tribes facing evidence-based model program mandates throughout the country.

Algorithms for computerized test construction using classical item parameters

NARCIS (Netherlands)

Adema, Jos J.; van der Linden, Willem J.

1989-01-01

Recently, linear programming models for test construction were developed. These models were based on the information function from item response theory. In this paper another approach is followed. Two 0-1 linear programming models for the construction of tests using classical item and test

Grumman OV-1C in flight

Science.gov (United States)

1983-01-01

Grumman OV-1C in flight. This OV-1C Mohawk, serial #67-15932, was used in a joint NASA/US Army Aviation Engineering Flight Activity (USAAEFA) program to study a stall-speed warning system in the early 1980s. NASA designed and built an automated stall-speed warning system which presented both airspeed and stall speed to the pilot. Visual indication of impending stall would be displayed to the pilot as a cursor or pointer located on a conventional airspeed indicator. In addition, an aural warning at predetermined stall margins was presented to the pilot through a voice synthesizer. The Mohawk was developed by Grumman Aircraft as a photo observation and reconnaissance aircraft for the US Marines and the US Army. The OV-1 entered production in October 1959 and served the US Army in Europe, Korea, the Viet Nam War, Central and South America, Alaska, and during Desert Shield/Desert Storm in the Middle East. The Mohawk was retired from service in September 1996. 133 OV-1Cs were built, the 'C' designating the model which used an IR (infrared) imaging system to provide reconnaissance.

阴道毛滴虫Rac1蛋白的cDNA克隆和序列分析%Molecular Cloning and Characterization of a Rac1 Homologue cDNA from Trichomonas vaginalis

Institute of Scientific and Technical Information of China (English)

傅玉才; 章家新; 郑晓虹; 刘红

2004-01-01

Objective To clone and characterize a Racl homologue from Trichomonas vaginalis for studying cell cycle of the organism. Methods A cDNA library derived from T. vaginalis mRNA was constructed into λ TriplEx2 phage vector. An expression sequence tag program was launched. Sequences of cDNA clones were analyzed using NCBI BLAST algorithms, and ClustalW and Treeview programs. Results A cDNA clone with a length of 714 base pairs was isolated. The sequence analysis showed that the cDNA clone has an open reading frame with 600 bp. The deduced amino acid sequence from the open reading frame contains 200 residuals and is most homologous to Rac1 subfamily of Rho GTPases with ＞ 60% identity. The conserved sequence elements of Rho GTPases, such as GTP-binding sites, GTPase-activating protein (GAP) interaction motifs, GTP-dissociation inhibitors (GDI) interaction motifs, guanine nucleotide exchange factor (GEF) interaction elements, etc, were detected in the amino acid sequence. The phylogenetic analysis showed that the cDNA clone is grouped in the Rac subfamily and is more closely related to Rac1 proteins of protozoa. Conclusion The cDNA clone isolated belongs to Rac subfamily of Rho GTPases and is probably a Rac1 protein of T. vaginalis.%目的获得阴道毛滴虫Rac1蛋白的cDNA克隆,研究其在细胞周期中的调解作用.方法提取阴道毛滴虫总RNA,构建cDNA表达文库,随机分离cDNA克隆并测序.用在线生物分析软件NCBI BLAST、ClustalW以及Treeview等程序进行序列分析.结果获得一株有714 bp的cDNA克隆.序列分析表明,该克隆开放阅读框具600 bp,推测肽链具200个氨基酸.该肽链与Rho家族中Rac1鸟苷三磷酸(GTP)酶同源性最高(＞60%),并具多种Rho GTP酶的保守基序,如GTP结合部位、GTP酶激活蛋白作用基序、GTP分离抑制因子作用基序、鸟嘌呤核苷酸交换因子作用基序等.进化树分析显示该克隆属于Rac亚家族GTP酶,与原虫Rac1蛋白最接近.结论该克隆�

Niemann-Pick C1 (NPC1/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor

Directory of Open Access Journals (Sweden)

Esther Ndungo

2012-10-01

Full Text Available We recently demonstrated that Niemann-Pick C1 (NPC1, a ubiquitous 13-pass cellular membrane protein involved in lysosomal cholesterol transport, is a critical entry receptor for filoviruses. Here we show that Niemann-Pick C1-like1 (NPC1L1, an NPC1 paralog and hepatitis C virus entry factor, lacks filovirus receptor activity. We exploited the structural similarity between NPC1 and NPC1L1 to construct and analyze a panel of chimeras in which NPC1L1 sequences were replaced with cognate sequences from NPC1. Only one chimera, NPC1L1 containing the second luminal domain (C of NPC1 in place of its own, bound to the viral glycoprotein, GP. This engineered protein mediated authentic filovirus infection nearly as well as wild-type NPC1, and more efficiently than did a minimal NPC1 domain C-based receptor recently described by us. A reciprocal chimera, NPC1 containing NPC1L1’s domain C, was completely inactive. Remarkably, an intra-domain NPC1L1-NPC1 chimera bearing only a ~130-amino acid N–terminal region of NPC1 domain C could confer substantial viral receptor activity on NPC1L1. Taken together, these findings account for the failure of NPC1L1 to serve as a filovirus receptor, highlight the central role of the luminal domain C of NPC1 in filovirus entry, and reveal the direct involvement of N–terminal domain C sequences in NPC1’s function as a filovirus receptor.

C-E productivity improvement program

International Nuclear Information System (INIS)

Chiu, C.; Ching, B.; Van Haltern, M.L.

1984-01-01

This paper describes the C-E Productivity Improvement Program (CEPIP), which is a computer algorithm for heat rate monitoring and diagnostics for a nuclear power plant. CEPIP uses the pattern recognition technique to identify cause(s) of heat rate degradation. The benefits of such an automated program to the plant performance engineer include early identification of the degrading component(s), provision of necessary economic information (cost of energy loss) to the performance engineer so that he can decide when to repair the degrading components, and identification of operator actions resulting in heat rate degradation (such as closing the valve on the live steam extraction line for the second stage of reheat). In summary, CEPIP improves the overall plant performance by increasing the capacity factor. CEPIP was developed to meet the growing needs of the utilities for an automated performance program. The diagnostic capability has been verified by plant data

Requirements for class 1C, 2C, and 3C pressure-retaining components and supports in CANDU nuclear power plants

International Nuclear Information System (INIS)

1989-01-01

This Standard applies to pressure-retaining components of CANDU nuclear power plants that have a code classification of Class 1C, 2C or 3C. These are pressure-retaining components where, because of the design concept, the rules of the ASME Boiler and Pressure Vessel Code do not exist, are not applicable, or are not sufficient. The Standard provides rules for the design, fabrication, installation, examination and inspection of these components and supports. It provides rules intended to ensure the pressure-retaining integrity of components, not the operability. It also provides rules for the support of fueling machines. The Standard applies only to new construction prior to the plant being declared in service

Matlab and C programming for Trefftz finite element methods

CERN Document Server

Qin, Qing-Hua

2008-01-01

Although the Trefftz finite element method (FEM) has become a powerful computational tool in the analysis of plane elasticity, thin and thick plate bending, Poisson's equation, heat conduction, and piezoelectric materials, there are few books that offer a comprehensive computer programming treatment of the subject. Collecting results scattered in the literature, MATLAB® and C Programming for Trefftz Finite Element Methods provides the detailed MATLAB® and C programming processes in applications of the Trefftz FEM to potential and elastic problems. The book begins with an introduction to th

The Impact of Ecological Construction Programs on Grassland Conservation in Inner Mongolia, China

NARCIS (Netherlands)

Liu, Min; Dries, Liesbeth; Heijman, Wim; Huang, Jikun; Zhu, Xueqin; Hu, Yuanning; Chen, Haibin

2018-01-01

A series of Ecological Construction Programs have been initiated to protect the condition of grasslands in China during recent decades. However, grassland degradation is still severe, and conditions have not been restored as intended. This paper aims to empirically examine the effectiveness of these

Trajectories of HbA1c Levels in Children and Youth with Type 1 Diabetes

Science.gov (United States)

Pinhas-Hamiel, Orit; Hamiel, Uri; Boyko, Valentina; Graph-Barel, Chana; Reichman, Brian; Lerner-Geva, Liat

2014-01-01

Purpose To illustrate the distribution of Hemoglobin A1c (HbA1c) levels according to age and gender among children, adolescents and youth with type 1 diabetes (T1DM). Methods Consecutive HbA1c measurements of 349 patients, aged 2 to 30 years with T1DM were obtained from 1995 through 2010. Measurement from patients diagnosed with celiac disease (n = 20), eating disorders (n = 41) and hemoglobinopathy (n = 1) were excluded. The study sample comprised 4815 measurements of HbA1c from 287 patients. Regression percentiles of HbA1c were calculated as a function of age and gender by the quantile regression method using the SAS procedure QUANTREG. Results Crude percentiles of HbA1c as a function of age and gender, and the modeled curves produced using quantile regression showed good concordance. The curves show a decline in HbA1c levels from age 2 to 4 years at each percentile. Thereafter, there is a gradual increase during the prepubertal years with a peak at ages 12 to 14 years. HbA1c levels subsequently decline to the lowest values in the third decade. Curves of females and males followed closely, with females having HbA1c levels about 0.1% (1.1 mmol/mol) higher in the 25th 50th and 75th percentiles. Conclusion We constructed age-specific distribution curves for HbA1c levels for patients with T1DM. These percentiles may be used to demonstrate the individual patient's measurements longitudinally compared with age-matched patients. PMID:25275650

Construction and uniqueness of the C*-Weyl algebra over a general pre-symplectic space

International Nuclear Information System (INIS)

Binz, Ernst; Honegger, Reinhard; Rieckers, Alfred

2004-01-01

A systematic approach to the C*-Weyl algebra W(E,σ) over a possibly degenerate pre-symplectic form σ on a real vector space E of possibly infinite dimension is elaborated in an almost self-contained manner. The construction is based on the theory of Kolmogorov decompositions for σ-positive-definite functions on involutive semigroups and their associated projective unitary group representations. The σ-positive-definite functions provide also the C*-norm of W(E,σ), the latter being shown to be *-isomorphic to the twisted group C*-algebra of the discrete vector group E. The connections to related constructions are indicated. The treatment of the fundamental symmetries is outlined for arbitrary pre-symplectic σ. The construction method is especially applied to the trivial symplectic form σ=0, leading to the commutative Weyl algebra over E, which is shown to be isomorphic to the C*-algebra of the almost periodic continuous function on the topological dual E τ ' of E with respect to an arbitrary locally convex Hausdorff topology τ on E. It is demonstrated that the almost periodic compactification aE τ ' of E τ ' is independent of the chosen locally convex τ on E, and that aE τ ' is continuously group isomorphic to the character group E of E. Applications of the results to the procedures of strict and continuous deformation quantizations are mentioned in the outlook

30 CFR 75.1708-1 - Surface structures; fireproof construction.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Surface structures; fireproof construction. 75... Surface structures; fireproof construction. Structures of fireproof construction is interpreted to mean structures with fireproof exterior surfaces. ...

The C1Σ+ state of KLi studied by polarization labelling spectroscopy technique

International Nuclear Information System (INIS)

Grochola, A.; Kowalczyk, P.; Jastrzebski, W.; Crozet, P.; Ross, A.J.

2002-01-01

The polarization labelling spectroscopy method is applied to study the C 1 Σ + - X 1 Σ + band system of the KLi molecule. Rotationally resolved polarization spectra are observed in the spectral range 17150 - 20350 cm -1 . A set of Dunham coefficients describes the C 1 Σ + state to 95% of its potential well depth, and the potential curve is constructed by the Rydberg-Klein-Rees procedure. The molecular parameters deduced from this work are compared with theoretical calculations. (author)

Construction of insertion and deletion mxa mutants of Methylobacterium extorquens AM1 by electroporation.

Science.gov (United States)

Toyama, H; Anthony, C; Lidstrom, M E

1998-09-01

Methylobacterium extorquens AM1 is a pink-pigmented facultative methylotroph which is widely used for analyzing pathways of C1 metabolism with biochemical and molecular biological techniques. To facilitate this approach, we have applied a new method to construct insertion or disruption mutants with drug resistance genes by electroporation. By using this method, mutants were obtained in four genes present in the mxa methylotrophy gene cluster for which the functions were unknown, mxaR, mxaS, mxaC and mxaD. These mutants were unable to grow on methanol except the mutant of mxaD, which showed reduced growth on methanol.

KNK I Test Program, Final Report Part 1

International Nuclear Information System (INIS)

Kathol, W.

1976-01-01

The compact sodium cooled nuclear reactor KNK I of the Karlsruhe Research Center reached full power for the first time in February 1974. The goal of KNK I is to collect experience for the construction and operation of larger reactors, such as SNR 300. In order to deepen these experiences, a test program was drawn up and conducted from 1973 until 1975 within the framework of R and D work on the development of fast breeder reactors. The program included individual tasks concerning reactor design, safety instrumentation, irradiation and post-examination as well as behavior of components during operation. The performance of the tests was essentially governed by the licensing procedure imposed under the atomic energy act for the construction and operation of nuclear facilities. This report is the first part of the final report of the test program

Sustainable construction: construction and demolition waste reconsidered.

Science.gov (United States)

del Río Merino, Mercedes; Izquierdo Gracia, Pilar; Weis Azevedo, Isabel Salto

2010-02-01

Construction activity in Europe has increased substantially in the past decade. Likewise, there has also been a commensurate rise in the generation of construction and demolition waste (C&DW). This, together with the fact that in many European countries the rate of recycling and reuse of C&DW is still quite low has engendered a serious environmental problem and a motivation to develop strategies and management plans to solve it. Due to its composition, there is a significant potential to reuse and/or recycle C&DW, and thereby, contribute to improving the sustainability of construction and development, but practical procedures are not yet widely known or practiced in the construction industry. This article (a) summarizes the different applications that are presently practiced to optimize the recovery and/or application of C&DW for reuse, and (b) proposes various measures and strategies to improve the processing of this waste. The authors suggest that to enhance environmental effectiveness, a conscious and comprehensive C&DW management plan should be implemented in each jurisdiction. More precisely, this study presents a holistic approach towards C&DW management, through which environmental benefits can be achieved through the application of new construction methods that can contribute to sustainable growth.

Program-oriented approach to resource saving issues in construction materials industry

Directory of Open Access Journals (Sweden)

Novikova Galina

2017-01-01

Full Text Available The construction as a sector of the economy is one of the largest consumers of energy resources, and the building materials industry is today one of the most energy-intensive construction industry. At the enterprises of the building materials industry the different approaches and methods are used to solve resource and energy problems. Energy saving is considered not as an complex approach in the enterprise activity, but as activity for the implementation of specific energy-saving projects, which have limitations in time and in resources. The authors suggest to use a softwareoriented approach to solving the problems of resource and energy saving. For practical application of program-oriented approach we offer to use a structuring method of the decision-making, not previously used to solve problems of resource and energy saving.

C1 Rational Quadratic Trigonometric Interpolation Spline for Data Visualization

Directory of Open Access Journals (Sweden)

Shengjun Liu

2015-01-01

Full Text Available A new C1 piecewise rational quadratic trigonometric spline with four local positive shape parameters in each subinterval is constructed to visualize the given planar data. Constraints are derived on these free shape parameters to generate shape preserving interpolation curves for positive and/or monotonic data sets. Two of these shape parameters are constrained while the other two can be set free to interactively control the shape of the curves. Moreover, the order of approximation of developed interpolant is investigated as O(h3. Numeric experiments demonstrate that our method can construct nice shape preserving interpolation curves efficiently.

33 CFR Appendix C to Part 273 - Information Requirements for Aquatic Plant Control Program Environmental Impact Statements

Science.gov (United States)

2010-07-01

... Aquatic Plant Control Program Environmental Impact Statements C Appendix C to Part 273 Navigation and... Environmental Impact Statements 1. Description of the problem. a. Pests. Identify the pest to be controlled by.... Relationship to environmental situation. Non-target organisms and integrated pest management programs. 2...

25 CFR 170.500 - What program reviews do the Secretaries conduct?

Science.gov (United States)

2010-04-01

... planning; (3) Design; (4) Contract administration; (5) Construction; (6) Financial management; and (7) Systems management and existing stewardship agreements. (c) After the IRR process review, the review team... RESERVATION ROADS PROGRAM Planning, Design, and Construction of Indian Reservation Roads Program Facilities...

HbA1c as a Predictor of Diabetes and as an Outcome in the Diabetes Prevention Program: A Randomized Clinical Trial

Science.gov (United States)

2015-01-01

OBJECTIVE Glycated hemoglobin (HbA1c), a standard measure of chronic glycemia for managing diabetes, has been proposed to diagnose diabetes and identify people at risk. The Diabetes Prevention Program (DPP) was a 3.2-year randomized clinical trial of preventing type 2 diabetes with a 10-year follow-up study, the DPP Outcomes Study (DPPOS). We evaluated baseline HbA1c as a predictor of diabetes and determined the effects of treatments on diabetes defined by an HbA1c ≥6.5% (48 mmol/mol). RESEARCH DESIGN AND METHODS We randomized 3,234 nondiabetic adults at high risk of diabetes to placebo, metformin, or intensive lifestyle intervention and followed them for the development of diabetes as diagnosed by fasting plasma glucose (FPG) and 2-h postload glucose (2hPG) concentrations (1997 American Diabetes Association [ADA] criteria). HbA1c was measured but not used for study eligibility or outcomes. We now evaluate treatment effects in the 2,765 participants who did not have diabetes at baseline according to FPG, 2hPG, or HbA1c (2010 ADA criteria). RESULTS Baseline HbA1c predicted incident diabetes in all treatment groups. Diabetes incidence defined by HbA1c ≥6.5% was reduced by 44% by metformin and 49% by lifestyle during the DPP and by 38% by metformin and 29% by lifestyle throughout follow-up. Unlike the primary DPP and DPPOS findings based on glucose criteria, metformin and lifestyle were similarly effective in preventing diabetes defined by HbA1c. CONCLUSIONS HbA1c predicted incident diabetes. In contrast to the superiority of the lifestyle intervention on glucose-defined diabetes, metformin and lifestyle interventions had similar effects in preventing HbA1c-defined diabetes. The long-term implications for other health outcomes remain to be determined. PMID:25336746

Programs of quality improvement: an exploratory study in large Brazilian construction companies

Directory of Open Access Journals (Sweden)

Silvia Helena Boarin Pinto

2009-03-01

Full Text Available This article aims to identify the major characteristics of the implementation of quality programs in large construction companies in Brazil. This study focuses on the most accepted and implemented models such as ISO 9000:2000, ISO 14001, Six Sigma and Total Quality Management (TQM. An exploratory study was carried out in seven large companies (approximately 37% of the total number. These companies were chosen from the “500 Largest and Best Brazilian Companies” list, published by Exame Magazine, in 2005, out of a total number of 15 large companies in the sector. The indings of this study show that the companies have been implementing quality programs, have been using more basic quality tools, and have been dificulty accounting resources that come from the implementation of quality programs.

TAP 1, Training Program Manual

International Nuclear Information System (INIS)

1991-01-01

Training programs at DOE nuclear facilities should provide well-trained, qualified personnel to safely and efficiently operate the facilities in accordance with DOE requirements. A need has been identified for guidance regarding analysis, design, development, implementation, and evaluation of consistent and reliable performance-based training programs. Accreditation of training programs at Category A reactors and high-hazard and selected moderate-hazard nonreactor nuclear facilities will assure consistent, appropriate, and cost-effective training of personnel responsible for the operation, maintenance, and technical support of these facilities. Training programs that are designed and based on systematically determined job requirements, instead of subjective estimation of trainee needs, yield training activities that are consistent and develop or improve knowledge, skills, and abilities that can be directly related to the work setting. Because the training is job-related, the content of these programs more efficiently meets the needs of the employee. Besides a better trained work force, a greater level of operational reactor safety can be realized. This manual is intended to provide an overview of the accreditation process and a brief description of the elements necessary to construct and maintain training programs that are based on the requirements of the job. Two companion manuals provide additional information to assist contractors in their efforts to accredit training programs

77 FR 12106 - Kapka Butte Sno-Park Construction

Science.gov (United States)

2012-02-28

... DEPARTMENT OF TRANSPORTATION Federal Highway Administration Kapka Butte Sno-Park Construction... Construction project. SUMMARY: The FHWA is issuing this notice to advise the public that the FHWA is officially designated as the Joint-Lead Agency pursuant to 23 U.S.C. 139(c)(1) for the Kapka Butte Sno-Park Construction...

Grumman OV-1C in hangar

Science.gov (United States)

1983-01-01

Grumman OV-1C in the hangar used at the time by the Army at Edwards Air Force Base. This OV-1C Mohawk, serial #67-15932, was used in a joint NASA/US Army Aviation Engineering Flight Activity (USAAEFA) program to study a stall-speed warning system in the early 1980s. NASA designed and built an automated stall-speed warning system which presented both airspeed and stall speed to the pilot. Visual indication of impending stall would be displayed to the pilot as a cursor or pointer located on a conventional airspeed indicator. In addition, an aural warning at predetermined stall margins was presented to the pilot through a voice synthesizer. The Mohawk was developed by Grumman Aircraft as a photo observation and electronic reconnaissance aircraft for the US Marines and the US Army. The OV-1 entered production in October 1959 and served the US Army in Europe, Korea, the Viet Nam War, Central and South America, Alaska, and during Desert Shield/Desert Storm in the Middle East. The Mohawk was retired from service in September 1996. 133 OV-1Cs were built, the 'C' designating the model which used an IR (infrared) imaging system to provide reconnaissance.

Constructing an I and C Upgrade Architecture for Korea Standard Nuclear Power Plants

International Nuclear Information System (INIS)

Suh, Yong Suk; Hur, Seop; Kim, Dong Hoon; Sung, Chan Ho; Kang, Hyun Tai; Lee, Jae Ki; Cho, Chang Hwan

2008-01-01

This paper presents three architectures of the KSNP I and C upgrade. The architectures are constructed with an adoption of PLCs and DCS technology and 3-phase upgrade strategy. The 3-phase upgrade strategy is established to ensure the safety of the upgrade. Based on the architecture, the cabinet configuration is being constructed. From the configuration, it is expected to figure out how to optimize the layout of the cabinets. It is required to study the performance and safety design requirements of the upgrade further

The Westinghouse approach - an I and C modernization program for WWERs

International Nuclear Information System (INIS)

Werner, C.L.; Wassel, W.W.; Novak, V.

1993-01-01

When entering into a design program that is a marriage between two designs it is very difficult to separate self imposed design criteria from the requirements of the program. Therefore, the criteria of and the requirements for the Westinghouse modernization program will be discussed as one. These are outlined below: 1) The OSART Mission that was conducted by the IAEA at the Temelin Plant in 1990 identified the need to provide a new comprehensive Safety Analysis to verify the various aspects of the WWER safety system design. This recommendation is one that Westinghouse will provide as part of the WWER I and C Modernization Program. The design, no matter how well proven or verified from a hardware design point of view, is only as good as the basis for the system design; 2) Minimize the impact on the civil design aspects of the plant where possible and where this requirements do not affect the safety features of the design; 3) Ensure compatibility of the design to meet the latest US NRC requirements and those of the implementing country, applicable to the systems functional and hardware designs. This is a Westinghouse standard corporate requirement for all nuclear plant and systems design whether they be foreign or domestic; 4) Provide the most modern, proven design for the I and C systems. Application of the Westinghouse Instrumentation and Control microprocessor based design to the WWER Modernization Program will provide the basis for upgrading plants to meet western standards. (author) 6 figs., 1 ref

Volatility study of [C1C1im][NTf2] and [C2C3im][NTf2] ionic liquids

International Nuclear Information System (INIS)

Rocha, Marisa A.A.; Ribeiro, Filipe M.S.; Schröder, Bernd; Coutinho, João A.P.; Santos, Luís M.N.B.F.

2014-01-01

Highlights: • Vapor pressures of [C 1 C 1 im][NTf 2 ] and [C 2 C 3 im][NTf 2 ] ionic liquids are reported. • [C 1 C 1 im][NTf 2 ] presents higher enthalpy and entropy of vaporization than expected. • The high volatility of [C 2 C 3 im][NTf 2 ] is a result from its asymmetric character. -- Abstract: Vapor pressures of 1,3-dimethylimidazolium bis(trifluoromethylsulfonyl)imide, ([C 1 C 1 im][NTf 2 ]) and 1-ethyl-3-propylimidazolium bis(trifluoromethylsulfonyl)imide, ([C 2 C 3 im][NTf 2 ]) ionic liquids were measured as a function of temperature using a Knudsen effusion apparatus combined with a quartz crystal microbalance. Enthalpies and entropies of vaporization were derived from the fitting of vapor pressure and temperature results to the Clarke and Glew equation. [C 1 C 1 im][NTf 2 ] presents a higher enthalpy and entropy of vaporization than the neighboring members of the series. The enthalpy of vaporization of [C 2 C 3 im][NTf 2 ] lies in between the asymmetric and symmetric ionic liquid series, reflecting a decrease in the electrostatic interactions due to a decrease of the charge accessibility between the ionic pairs when the methyl group is replaced by an ethyl group. The obtained higher volatility of [C 2 C 3 im][NTf 2 ] arises from its asymmetric character, leading to an higher entropic contribution that compensates the enthalpic penalty. The border conditions ([C 1 C 1 im][NTf 2 ], [C 2 C 1 im][NTf 2 ] and [C 2 C 2 im][NTf 2 ]), topology ([C 2 C 3 im][NTf 2 ]) and symmetry/asymmetry of the ILs effect were evaluated and rationalized based on a comparative analysis of the thermodynamic properties, enthalpies and entropies of vaporization

Lessons learned from new construction utility demand side management programs and their implications for implementing building energy codes

Energy Technology Data Exchange (ETDEWEB)

Wise, B.K.; Hughes, K.R.; Danko, S.L.; Gilbride, T.L.

1994-07-01

This report was prepared for the US Department of Energy (DOE) Office of Codes and Standards by the Pacific Northwest Laboratory (PNL) through its Building Energy Standards Program (BESP). The purpose of this task was to identify demand-side management (DSM) strategies for new construction that utilities have adopted or developed to promote energy-efficient design and construction. PNL conducted a survey of utilities and used the information gathered to extrapolate lessons learned and to identify evolving trends in utility new-construction DSM programs. The ultimate goal of the task is to identify opportunities where states might work collaboratively with utilities to promote the adoption, implementation, and enforcement of energy-efficient building energy codes.

On the GKP and BS constructions of the c-boundary

International Nuclear Information System (INIS)

Kuang zhi-quan; Liang can-bin

1988-01-01

Two examples are presented in this paper, the first is unfavorable to the c-boundary construction given by Geroch, Kronheimer, and Penrose [Proc. R. Soc. London Ser. A 327, 545 (1972)] but in favor of that given by Budic and Sachs [J. Math. Phys. 15, 1302 (1974)], while the second plays an opposite role. The second example is also an example of a causally continuous space-time with a ''really big gap,'' contrary to what was believed in the literature

Catalytic constructive deoxygenation of lignin-derived phenols: new C-C bond formation processes from imidazole-sulfonates and ether cleavage reactions.

Science.gov (United States)

Leckie, Stuart M; Harkness, Gavin J; Clarke, Matthew L

2014-10-09

As part of a programme aimed at exploiting lignin as a chemical feedstock for less oxygenated fine chemicals, several catalytic C-C bond forming reactions utilising guaiacol imidazole sulfonate are demonstrated. These include the cross-coupling of a Grignard, a non-toxic cyanide source, a benzoxazole, and nitromethane. A modified Meyers reaction is used to accomplish a second constructive deoxygenation on a benzoxazole functionalised anisole.

Applications of Environmental Remote Sensing by HJ-1C SAR Imageries

Directory of Open Access Journals (Sweden)

Tian Wei

2014-06-01

Full Text Available The HJ-1C satellite was successfully launched in November 19, 2012. The HJ-1C and HJ-1A/1B satellites, which were launched in September 06, 2008, constitute the “2+1” small satellite constellation for environmental and disaster monitoring. This study focuses on the analysis and evaluation of the satellite performance with respect to environmental remote sensing, including land use interpretation, land cover classification, oil spill identification, retrieval of sea waves, and monitoring of coastal mariculture. The data used in this study cover the city of Beijing and the sea of the Fujian Province. Nine HJ-1C satellite images (level-2, S band, VV Pol, strip mode, 5 m resolution from December 2012 to January 2013 are used. The conclusions are as follows: (1 the HJ-1C SAR images can be used to manually identify farmland, woodland, roads, rivers, urban construction, and rural residential areas; (2 the accuracy of the automatic land cover classification increased significantly when the HJ-1C SAR and HJ-1B CCD fusion images are used; (3 the HJ-1C satellite can be used to identify oil spills, to invert wave parameters, and to extract information regarding inshore aquaculture.

Employers' Perception of Graduates with Entry-Level Technical Skills from Construction Industry Programs in Ghana and Nigeria

Science.gov (United States)

Acheampong, Philip

2013-01-01

The purpose of this comparative study was to identify the technical skills and abilities needed by prospective employees of construction industries in Ghana and Nigeria. Potential employees were defined here as recent graduates of construction industry programs with entry-level technical skills. The continuous growth in and expansion of these two…

A quantum group approach to cL > 1 Liouville gravity

International Nuclear Information System (INIS)

Suzuki, Takashi.

1995-03-01

A candidate of c L > 1 Liouville gravity is studied via infinite dimensional representations of U q sl(2, C) with q at a root of unity. We show that vertex operators in this Liouville theory are factorized into classical vertex operators and those which are constructed from finite dimensional representations of U q sl(2, C). Expressions of correlation functions and transition amplitudes are presented. We discuss about our results and find an intimate relation between our quantization of the Liouville theory and the geometric quantization of moduli space of Riemann surfaces. An interpretation of quantum space-time is also given within this formulation. (author)

Construction of cDNA library and preliminary analysis of expressed sequence tags from Siberian tiger

Science.gov (United States)

Liu, Chang-Qing; Lu, Tao-Feng; Feng, Bao-Gang; Liu, Dan; Guan, Wei-Jun; Ma, Yue-Hui

2010-01-01

In this study we successfully constructed a full-length cDNA library from Siberian tiger, Panthera tigris altaica, the most well-known wild Animal. Total RNA was extracted from cultured Siberian tiger fibroblasts in vitro. The titers of primary and amplified libraries were 1.30×106 pfu/ml and 1.62×109 pfu/ml respectively. The proportion of recombinants from unamplified library was 90.5% and average length of exogenous inserts was 1.13 kb. A total of 282 individual ESTs with sizes ranging from 328 to 1,142bps were then analyzed the BLASTX score revealed that 53.9% of the sequences were classified as strong match, 38.6% as nominal and 7.4% as weak match. 28.0% of them were found to be related to enzyme/catalytic protein, 20.9% ESTs to metabolism, 13.1% ESTs to transport, 12.1% ESTs to signal transducer/cell communication, 9.9% ESTs to structure protein, 3.9% ESTs to immunity protein/defense metabolism, 3.2% ESTs to cell cycle, and 8.9 ESTs classified as novel genes. These results demonstrated that the reliability and representativeness of the cDNA library attained to the requirements of a standard cDNA library. This library provided a useful platform for the functional genomic research of Siberian tigers. PMID:20941376

Construction of a psb C deletion strain in Synechocystis 6803.

Science.gov (United States)

Goldfarb, N; Knoepfle, N; Putnam-Evans, C

1997-01-01

Synechocystis 6803 is a cyanobacterium that carries out-oxygenic photosynthesis. We are interested in the introduction of mutations in the large extrinsic loop region of the CP43 protein of Photosystem II (PSII). CP43 appears to be required for the stable assembly of the PSII complex and also appears to play a role in photosynthetic oxygen evolution. Deletion of short segments of the large extrinsic loop results in mutants incapable of evolving oxygen. Alterations in psbC, the gene encoding CP43, are introduced into Synechocystis 6803 by transformation and homologous recombination. Specifically, plasmid constructs bearing the site-directed mutations are introduced into a deletion strain where the portion of the gene encoding the area of mutation has been deleted and replaced by a gene conferring antibiotic resistance. We have constructed a deletion strain of Synechocystis appropriate for the introduction of mutations in the large extrinsic loop of CP43 and have used it successfully to produce site-directed mutants.

Project W-320, 241-C-106 sluicing: Construction specification W-320-C2

International Nuclear Information System (INIS)

Bailey, J.W.

1998-01-01

This supporting document has been prepared to make the construction specifications for Project W-320 readily available. Project W-320, Waste Retrieval Sluicing System (WRSS), specification is for procurement, fabrication and installation of equipment at the C Tank Farm, including Operator Station and some equipment just outside the C Tank Farm fence, necessary to support the sluicing operation. Work consists of furnishing labor, equipment, and materials to provide the means to procure materials and equipment, fabricate items, excavate and place concrete, and install equipment, piping, wiring, and structures in accordance with the Contract Documents. Major work elements include: Excavation for process and fire protection piping, electrical conduit trenches, and foundations for small structures; Placement of concrete cover blocks, foundations, and equipment pads; Procurement and installation of double walled piping, electrical conduit, fire and raw water piping, chilled water piping, and electrical cable; Procurement and installation of above-ground ventilation system piping between the (HVAC) Process building and Tank C-106; Core drill existing concrete; Furnish and installation of electrical distribution equipment; Installation of the concrete foundation, and assembly installation of the two Seismic Shutdown Systems with Environmental Enclosures; Fabrication and installation of in-pit pipe jumpers, including related valves, instruments and wiring; and Installation of a vertical submersible pump, horizontal booster pump, and winch assembly into tank access riser pits

Project W-320, 241-C-106 sluicing: Construction specification W-320-C2

Energy Technology Data Exchange (ETDEWEB)

Bailey, J.W.

1998-07-20

This supporting document has been prepared to make the construction specifications for Project W-320 readily available. Project W-320, Waste Retrieval Sluicing System (WRSS), specification is for procurement, fabrication and installation of equipment at the C Tank Farm, including Operator Station and some equipment just outside the C Tank Farm fence, necessary to support the sluicing operation. Work consists of furnishing labor, equipment, and materials to provide the means to procure materials and equipment, fabricate items, excavate and place concrete, and install equipment, piping, wiring, and structures in accordance with the Contract Documents. Major work elements include: Excavation for process and fire protection piping, electrical conduit trenches, and foundations for small structures; Placement of concrete cover blocks, foundations, and equipment pads; Procurement and installation of double walled piping, electrical conduit, fire and raw water piping, chilled water piping, and electrical cable; Procurement and installation of above-ground ventilation system piping between the (HVAC) Process building and Tank C-106; Core drill existing concrete; Furnish and installation of electrical distribution equipment; Installation of the concrete foundation, and assembly installation of the two Seismic Shutdown Systems with Environmental Enclosures; Fabrication and installation of in-pit pipe jumpers, including related valves, instruments and wiring; and Installation of a vertical submersible pump, horizontal booster pump, and winch assembly into tank access riser pits.

Project W-320, 241-C-106 sluicing: Construction specification W-320-C6

International Nuclear Information System (INIS)

Bailey, J.W.

1998-01-01

This supporting document has been prepared to make the construction specifications for Project W-320 readily available. Project W-320, Waste Retrieval Sluicing System (WRSS), specification is for procurement, fabrication and installation of equipment at the C Tank Farm, including Operator Station and some equipment just outside the C Tank Farm fence, necessary to support the sluicing operation. Work consists of furnishing labor, equipment, and materials to provide the means to procure materials and equipment, fabricate items, excavate and place concrete, and install equipment, piping, wiring, and structures in accordance with the Contract Documents. Major work elements include: Excavation for process and fire protection piping, electrical conduit trenches, and foundations for small structures; Placement of concrete cover blocks, foundations, and equipment pads; Procurement and installation of double walled piping, electrical conduit, fire and raw water piping, chilled water piping, and electrical cable; Procurement and installation of above-ground ventilation system piping between the (HVAC) Process building and Tank C-106; Core drill existing concrete; Furnish and installation of electrical distribution equipment; Installation of the concrete foundation, and assembly installation of the two Seismic Shutdown Systems with Environmental Enclosures; Fabrication and installation of in-pit pipe jumpers, including related valves, instruments and wiring; and Installation of a vertical submersible pump, horizontal booster pump, and winch assembly into tank access riser pits

Project W-320, 241-C-106 sluicing: Construction specification W-320-C5

International Nuclear Information System (INIS)

Bailey, J.W.

1998-01-01

This supporting document has been prepared to make the construction specifications for Project W-320 readily available. Project W-320, Waste Retrieval Sluicing System (WRSS), specification is for procurement, fabrication and installation of equipment at the C Tank Farm, including Operator Station and some equipment just outside the C Tank Farm fence, necessary to support the sluicing operation. Work consists of furnishing labor, equipment, and materials to provide the means to procure materials and equipment, fabricate items, excavate and place concrete, and install equipment, piping, wiring, and structures in accordance with the Contract Documents. Major work elements include: Excavation for process and fire protection piping, electrical conduit trenches, and foundations for small structures; Placement of concrete cover blocks, foundations, and equipment pads; Procurement and installation of double walled piping, electrical conduit, fire and raw water piping, chilled water piping, and electrical cable; Procurement and installation of above-ground ventilation system piping between the (HVAC) Process building and Tank C-106; Core drill existing concrete; Furnish and installation of electrical distribution equipment; Installation of the concrete foundation, and assembly installation of the two Seismic Shutdown Systems with Environmental Enclosures; Fabrication and installation of in-pit pipe jumpers, including related valves, instruments and wiring; and Installation of a vertical submersible pump, horizontal booster pump, and winch assembly into tank access riser pits

Project W-320, 241-C-106 sluicing: Construction specification W-320-C7

International Nuclear Information System (INIS)

Bailey, J.W.

1998-01-01

This supporting document has been prepared to make the construction specifications for Project W-320 readily available. Project W-320, Waste Retrieval Sluicing System (WRSS), specification is for procurement, fabrication and installation of equipment at the C Tank Farm, including Operator Station and some equipment just outside the C Tank Farm fence, necessary to support the sluicing operation. Work consists of furnishing labor, equipment, and materials to provide the means to procure materials and equipment, fabricate items, excavate and place concrete, and install equipment, piping, wiring, and structures in accordance with the Contract Documents. Major work elements include: Excavation for process and fire protection piping, electrical conduit trenches, and foundations for small structures; Placement of concrete cover blocks, foundations, and equipment pads; Procurement and installation of double walled piping, electrical conduit, fire and raw water piping, chilled water piping, and electrical cable; Procurement and installation of above-ground ventilation system piping between the (HVAC) Process building and Tank C-106; Core drill existing concrete; Furnish and installation of electrical distribution equipment; Installation of the concrete foundation, and assembly installation of the two Seismic Shutdown Systems with Environmental Enclosures; Fabrication and installation of in-pit pipe jumpers, including related valves, instruments and wiring; and Installation of a vertical submersible pump, horizontal booster pump, and winch assembly into tank access riser pits

Project W-320, 241-C-106 sluicing: Construction specification W-320-C5

Energy Technology Data Exchange (ETDEWEB)

Bailey, J.W.

1998-07-20

This supporting document has been prepared to make the construction specifications for Project W-320 readily available. Project W-320, Waste Retrieval Sluicing System (WRSS), specification is for procurement, fabrication and installation of equipment at the C Tank Farm, including Operator Station and some equipment just outside the C Tank Farm fence, necessary to support the sluicing operation. Work consists of furnishing labor, equipment, and materials to provide the means to procure materials and equipment, fabricate items, excavate and place concrete, and install equipment, piping, wiring, and structures in accordance with the Contract Documents. Major work elements include: Excavation for process and fire protection piping, electrical conduit trenches, and foundations for small structures; Placement of concrete cover blocks, foundations, and equipment pads; Procurement and installation of double walled piping, electrical conduit, fire and raw water piping, chilled water piping, and electrical cable; Procurement and installation of above-ground ventilation system piping between the (HVAC) Process building and Tank C-106; Core drill existing concrete; Furnish and installation of electrical distribution equipment; Installation of the concrete foundation, and assembly installation of the two Seismic Shutdown Systems with Environmental Enclosures; Fabrication and installation of in-pit pipe jumpers, including related valves, instruments and wiring; and Installation of a vertical submersible pump, horizontal booster pump, and winch assembly into tank access riser pits.

Project W-320, 241-C-106 sluicing: Construction specification W-320-C7

Energy Technology Data Exchange (ETDEWEB)

Bailey, J.W.

1998-07-20

This supporting document has been prepared to make the construction specifications for Project W-320 readily available. Project W-320, Waste Retrieval Sluicing System (WRSS), specification is for procurement, fabrication and installation of equipment at the C Tank Farm, including Operator Station and some equipment just outside the C Tank Farm fence, necessary to support the sluicing operation. Work consists of furnishing labor, equipment, and materials to provide the means to procure materials and equipment, fabricate items, excavate and place concrete, and install equipment, piping, wiring, and structures in accordance with the Contract Documents. Major work elements include: Excavation for process and fire protection piping, electrical conduit trenches, and foundations for small structures; Placement of concrete cover blocks, foundations, and equipment pads; Procurement and installation of double walled piping, electrical conduit, fire and raw water piping, chilled water piping, and electrical cable; Procurement and installation of above-ground ventilation system piping between the (HVAC) Process building and Tank C-106; Core drill existing concrete; Furnish and installation of electrical distribution equipment; Installation of the concrete foundation, and assembly installation of the two Seismic Shutdown Systems with Environmental Enclosures; Fabrication and installation of in-pit pipe jumpers, including related valves, instruments and wiring; and Installation of a vertical submersible pump, horizontal booster pump, and winch assembly into tank access riser pits.

Project W-320, 241-C-106 sluicing: Construction specification W-320-C6

Energy Technology Data Exchange (ETDEWEB)

Bailey, J.W.

1998-07-20

This supporting document has been prepared to make the construction specifications for Project W-320 readily available. Project W-320, Waste Retrieval Sluicing System (WRSS), specification is for procurement, fabrication and installation of equipment at the C Tank Farm, including Operator Station and some equipment just outside the C Tank Farm fence, necessary to support the sluicing operation. Work consists of furnishing labor, equipment, and materials to provide the means to procure materials and equipment, fabricate items, excavate and place concrete, and install equipment, piping, wiring, and structures in accordance with the Contract Documents. Major work elements include: Excavation for process and fire protection piping, electrical conduit trenches, and foundations for small structures; Placement of concrete cover blocks, foundations, and equipment pads; Procurement and installation of double walled piping, electrical conduit, fire and raw water piping, chilled water piping, and electrical cable; Procurement and installation of above-ground ventilation system piping between the (HVAC) Process building and Tank C-106; Core drill existing concrete; Furnish and installation of electrical distribution equipment; Installation of the concrete foundation, and assembly installation of the two Seismic Shutdown Systems with Environmental Enclosures; Fabrication and installation of in-pit pipe jumpers, including related valves, instruments and wiring; and Installation of a vertical submersible pump, horizontal booster pump, and winch assembly into tank access riser pits.

SNEAK assembly 12B - Construction and experimental program

International Nuclear Information System (INIS)

Helm, F.

1982-10-01

The assembly SNEAK 12A is the second SNEAK assembly in which the neutron physics of disturbed material configurations, as they might occur in a postulated fast reactor accident, is investigated. The core is characterized by a central zone with fuel rods containing PuO 2 UO 2 mixed oxide pellets. This zone is cylindrically surrounded by a buffer zone for spectral adaptation, a driver zone sufficiently reactive to maintain criticality and a radial depleted uranium blanket. The purpose of the experiments is to test calculational methods of neutron physics which are used in the accident analysis of fast breeder reactors. The report describes the construction of the core and its assemblies and their content and outlines the foreseen experimental program. It includes measurements in the clean critical core and investigations of vertical and horizontal fuel relocations and steel blockages

A revised simplex method for test construction problems

NARCIS (Netherlands)

Adema, Jos J.; Adema, J.J.

1990-01-01

Linear programming models with 0-1 variables are useful for the construction of tests from an item bank. Most solution strategies for these models start with solving the relaxed 0-1 linear programming model, allowing the 0-1 variables to take on values between 0 and 1. Then, a 0-1 solution is found

SYSTEMIC INNOVATION IN CONSTRUCTION: THE

DEFF Research Database (Denmark)

Jensen, Jens Stissing; Koch, Christian

2007-01-01

-based. This approach evaluates the outcome of the program against the main intentions formulated in the tender material. Drawing on systemic innovation theory an alternative evaluative approach is suggested which focuses on the build-up of organizational and institutional resources to support the development...... of an emerging ICT trajectory. While the result-based evaluation points to some weaknesses in the quality of the best-practice and cross-organizational elements of the case-material, the systemic approach point to some important sideeffects of the program, such as the stabilization and enrolment of the industry......This paper offers an evaluation of a best practice program called ‘Best in Construction’ (BiC) which aimed to identify and document cases of successful ICT use in the Danish construction industry. The program is evaluated using two different approaches. The first approach is result...

Complete cDNA sequence of human complement C1s and close physical linkage of the homologous genes C1s and C1r

International Nuclear Information System (INIS)

Tosi, M.; Duponchel, C.; Meo, T.; Julier, C.

1987-01-01

Overlapping molecular clones encoding the complement subcomponent C1s were isolated from a human liver cDNA library. The nucleotide sequence reconstructed from these clones spans about 85% of the length of the liver C1s messenger RNAs, which occur in three distinct size classes around 3 kilobases in length. Comparisons with the sequence of C1r, the other enzymatic subcomponent of C1, reveal 40% amino acid identity and conservation of all the cysteine residues. Beside the serine protease domain, the following sequence motifs, previously described in C1r, were also found in C1s: (a) two repeats of the type found in the Ba fragment of complement factor B and in several other complement but also noncomplement proteins, (b) a cysteine-rich segment homologous to the repeats of epidermal growth factor precursor, and (c) a duplicated segment found only in C1r and C1s. Differences in each of these structural motifs provide significant clues for the interpretation of the functional divergence of these interacting serine protease zymogens. Hybridizations of C1r and C1s probes to restriction endonuclease fragments of genomic DNA demonstrate close physical linkage of the corresponding genes. The implications of this finding are discussed with respect to the evolution of C1r and C1s after their origin by tandem gene duplication and to the previously observed combined hereditary deficiencies of Clr and Cls

Trust in Leadership DEOCS 4.1 Construct Validity Summary

Science.gov (United States)

2017-08-01

Trust in Leadership DEOCS 4.1 Construct Validity Summary DEFENSE EQUAL OPPORTUNITY MANAGEMENT INSTITUTE...Report #04-18 1 Trust in Leadership DEOCS 4.1 Construct Validity Summary Background In 2014, DEOMI released DEOCS 4.0 for Department of Defense...and individual items on the DEOCS. The following details the efforts directed toward updating the factor of Trust in Leadership . Included is a review

Inclusion at Work DEOCS 4.1 Construct Validity Summary

Science.gov (United States)

2017-08-01

Inclusion at Work DEOCS 4.1 Construct Validity Summary DEFENSE EQUAL OPPORTUNITY MANAGEMENT INSTITUTE DIRECTORATE...Report #10-18 1 Inclusion DEOCS 4.1 Construct Validity Summary Background In 2011, the Department of Defense (DoD) published the Government-Wide...Diversity and Inclusion Strategic Plan that established a government-wide initiative to promote Diversity and Inclusion . While the military is a

Correlation between safety climate and contractor safety assessment programs in construction.

Science.gov (United States)

Sparer, Emily H; Murphy, Lauren A; Taylor, Kathryn M; Dennerlein, Jack T

2013-12-01

Contractor safety assessment programs (CSAPs) measure safety performance by integrating multiple data sources together; however, the relationship between these measures of safety performance and safety climate within the construction industry is unknown. Four hundred and one construction workers employed by 68 companies on 26 sites and 11 safety managers employed by 11 companies completed brief surveys containing a nine-item safety climate scale developed for the construction industry. CSAP scores from ConstructSecure, Inc., an online CSAP database, classified these 68 companies as high or low scorers, with the median score of the sample population as the threshold. Spearman rank correlations evaluated the association between the CSAP score and the safety climate score at the individual level, as well as with various grouping methodologies. In addition, Spearman correlations evaluated the comparison between manager-assessed safety climate and worker-assessed safety climate. There were no statistically significant differences between safety climate scores reported by workers in the high and low CSAP groups. There were, at best, weak correlations between workers' safety climate scores and the company CSAP scores, with marginal statistical significance with two groupings of the data. There were also no significant differences between the manager-assessed safety climate and the worker-assessed safety climate scores. A CSAP safety performance score does not appear to capture safety climate, as measured in this study. The nature of safety climate in construction is complex, which may be reflective of the challenges in measuring safety climate within this industry. Am. J. Ind. Med. 56:1463-1472, 2013. © 2013 Wiley Periodicals, Inc. © 2013 Wiley Periodicals, Inc.

Construction of relativistic quantum theory: a progress report

International Nuclear Information System (INIS)

Noyes, H.P.

1986-06-01

We construct the particulate states of quantum physics using a recursive computer program that incorporates non-determinism by means of locally arbitrary choices. Quantum numbers and coupling constants arise from the construction via the unique 4-level combinatorial hierarchy. The construction defines indivisible quantum events with the requisite supraluminal correlations, yet does not allow supraluminal communication. Measurement criteria incorporate c, h-bar and m/sub p/ or (not ''and'') G, connected to laboratory events via finite particle number scattering theory and the counter paradigm. The resulting theory is discrete throughout, contains no infinities, and, as far as we have developed it, is in agreement with quantum mechanical and cosmological fact

Pharmacogenetics of aldo-keto reductase 1C (AKR1C) enzymes.

Science.gov (United States)

Alshogran, Osama Y

2017-10-01

Genetic variation in metabolizing enzymes contributes to variable drug response and disease risk. Aldo-keto reductase type 1C (AKR1C) comprises a sub-family of reductase enzymes that play critical roles in the biotransformation of various drug substrates and endogenous compounds such as steroids. Several single nucleotide polymorphisms have been reported among AKR1C encoding genes, which may affect the functional expression of the enzymes. Areas covered: This review highlights and comprehensively discusses previous pharmacogenetic reports that have examined genetic variations in AKR1C and their association with disease development, drug disposition, and therapeutic outcomes. The article also provides information about the effect of AKR1C genetic variants on enzyme function in vitro. Expert opinion: The current evidence that links the effect of AKR1C gene polymorphisms to disease progression and development is inconsistent and needs further validation, despite of the tremendous knowledge available. Information about association of AKR1C genetic variants and drug efficacy, safety, and pharmacokinetics is limited, thus, future studies that advance our understanding about these relationships and their clinical relevance are needed. It is imperative to achieve consistent findings before the potential translation and adoption of AKR1C genetic variants in clinical practice.

Participation in a farmers' market fruit and vegetable prescription program at a federally qualified health center improves hemoglobin A1C in low income uncontrolled diabetics

Directory of Open Access Journals (Sweden)

Richard Bryce

2017-09-01

Access to a fruit and vegetable prescription program over a 13-week period led to decreased HbA1C concentrations in uncontrolled type 2 diabetic patients living in an urban area of predominately-lower socioeconomic status.

Construction of a recombinant eukaryotic human ZHX1 gene expression plasmid and the role of ZHX1 in hepatocellular carcinoma.

Science.gov (United States)

Wang, Jianping; Liu, Dejie; Liang, Xiaohong; Gao, Lifen; Yue, Xuetian; Yang, Yang; Ma, Chunhong; Liu, Jun

2013-11-01

The zinc-fingers and homeoboxes protein 1 (ZHX1) consists of 873 amino acid residues, is localized in the cell nucleus and appears to act as a transcriptional repressor. Previous studies have shown that ZHX1 interacts with nuclear factor Y subunit α (NF-YA), DNA methyltransferases (DNMT) 3B and ZHX2, all of which are involved in tumorigenesis. However, the exact role of ZHX1 in tumorigenesis remains unknown. The aim of the current study was to construct a recombinant eukaryotic expression plasmid containing the human ZHX1 (hZHX1) gene and to investigate the biological activities of ZHX1 in hepatocellular carcinoma (HCC). Reverse transcription-polymerase chain reaction (RT‑PCR) was used to amplify the N- and C-terminal fragments (ZHX1‑N and ZHX1‑C, respectively) of the hZHX1 gene. The two PCR fragments were cloned into the pEASY-T1 vector and subcloned into the pcDNA3 plasmid to generate a recombinant pcDNA3‑ZHX1 plasmid. Following identification by enzyme digestion and DNA sequencing, the recombinant pcDNA3‑ZHX1 plasmid was transfected into SMMC-7721 cells. The level of ZHX1 expression was detected by RT-PCR and western blot analysis. Cell growth curve assays were used to evaluate the effect of ZHX1 on cell proliferation. Moreover, the differential expression of ZHX1 between cancer and adjacent cirrhotic liver tissue was investigated by quantitative PCR (qPCR). Enzyme digestion and DNA sequencing confirmed the successful construction of the recombinant plasmid, pcDNA3‑ZHX1. qPCR and western blot analysis demonstrated that ZHX1 was efficiently expressed in SMMC-7721 cells and overexpression of ZHX1 may inhibit the proliferation of SMMC-7721 cells. In addition, reduced ZHX1 expression is widespread among cancer tissues from HCC patients. In conclusion, a recombinant eukaryotic expression plasmid, pcDNA3‑ZHX1, was successfully constructed. In addition, the current results indicate that a low expression of ZHX1 may be responsible for hepatocarcinogenesis.

Constructing Hardware in a Scale Embedded Language

Energy Technology Data Exchange (ETDEWEB)

2014-08-21

Chisel is a new open-source hardware construction language developed at UC Berkeley that supports advanced hardware design using highly parameterized generators and layered domain-specific hardware languages. Chisel is embedded in the Scala programming language, which raises the level of hardware design abstraction by providing concepts including object orientation, functional programming, parameterized types, and type inference. From the same source, Chisel can generate a high-speed C++-based cycle-accurate software simulator, or low-level Verilog designed to pass on to standard ASIC or FPGA tools for synthesis and place and route.

Synthesis of 1-13C-1-indanone and 2-13C-1,2,3,4-tetrahydroquinoline

International Nuclear Information System (INIS)

Pickering, R.E.; Wysocki, M.A.; Eisenbraun, E.J.

1985-01-01

The synthesis of 2- 13 C-1,2,3,4-tetrahydroquinoline (5) via 1- 13 C-3-phenylpropanoic acid (1), 1- 13 C-1-indanone (2), 1- 13 C-1-indanone hydrazone (3) and 2- 13 C-3,4-dihydro-2(1H)-quinolinone (4) proceeded in 78, 96, 95, 79, and 85% individual yields respectively for 1, 2, 3, 4, 5 and 61% overall yield of the latter from 1. (author)

Basic research program for innovated coal utilization in Japan. BRAIN-C program; Sekitan riyo kiban gijutsu kaihatsu. BRAIN-C program

Energy Technology Data Exchange (ETDEWEB)

Harada, M [Center for Coal Utilization, Japan, Tokyo (Japan)

1996-09-01

This paper introduces the circumstances and purpose of establishing the Basic Research Associate for Innovated Coal Utilization (BRAIN-C) Program started in October 1995, and the summary of the results therefrom in fiscal 1995. Although development of coal utilization technologies has been implemented over a number of years, there are many problems still requiring solutions. Early realization has been urged on diversification of coal utilization, acceleration of technological development and diversification of coal types. In order to achieve these goals, the necessity was recognized afresh on not only the hardwares, but also on basic technologies in terms of software which can identify properties of coals, systematize different reactions, and estimate reactions, fluidity and heat transmission of coals. Therefore, receiving a subsidy from the Agency of Natural Resources and Energy of the Ministry of International Trade and Industry, a research and development program to be implemented jointly by industries, administrative agencies and academic societies had been started with a five-year plan for the time being. With the activities for the program such as collecting 50 to 100 types of coals and supplying them to researchers, the program had been accelerated in fiscal 1995 on a large number of themes and results therefrom, including fundamental properties and thermo-chemical reactions. 2 figs., 4 tabs.

Quality assurance program description. Topical report SDQAPD-1

International Nuclear Information System (INIS)

1975-01-01

The topical report presented describes the SDG and E QA Program that is applied to the design, procurement, construction, and preoperational testing of nuclear power plants. The QA plan describes the SDG and E organizational structure for quality assurance; identifies the functions, duties, and responsibilities of key departments and individuals; describes interrelationships and interfaces among internal groups and external organizations; delineates program requirements, and prescribes methods of implementation. SDG and E Procedures and Directives provide detailed direction for accomplishment of program requirements in consonance with the methods specified in the QA Plan

Synthesis of [5,6-13C2, 1-14C]olivetolic acid, methyl [1'-13C]olivetolate and [5,6-13C2, 1-14C]cannabigerolic acid

International Nuclear Information System (INIS)

Porwoll, J.P.; Leete, E.

1985-01-01

Potential advanced intermediates in the biosynthesis of delta 9 -tetrahydrocannabinol, the major psychoactive principle of marijuana, have been synthesized labeled with two contiguous 13 C atoms and 14 C. Methyl [5,6- 13 C 2 , 1- 14 C]olivetolate was prepared from lithium [ 13 C 2 ]acetylide and dimethyl [2- 14 C]malonate. Reaction with geranyl bromide afforded methyl [5,6- 13 C 2 , 1- 14 C]cannabigerolate, and hydrolysis of these methyl esters with lithium propyl mercaptide yielded the corresponding labeled acids. The 13 C- 13 C couplings observable in the 13 C NMR spectra of these 13 C-enriched compounds and their synthetic precursors are recorded. Methyl [1'- 14 C]olivetolate was prepared from 13 CO 2 to confirm assignments of the 13 C chemical shifts in the pentyl side chain of these compounds. (author)

Production and construction technology of C100 high strength concrete filled steel tube

Science.gov (United States)

Wu, Yanli; Sun, Jinlin; Yin, Suhua; Liu, Yu

2017-10-01

In this paper, the effect of the amount of cement, water cement ratio and sand ratio on compressive strength of C100 concrete was studied. The optimum mix ratio was applied to the concrete filled steel tube for the construction of Shenyang Huangchao Wanxin mansion. The results show that the increase of amount of cement, water cement ratio can improve the compressive strength of C100 concrete but increased first and then decreased with the increase of sand ratio. The compressive strength of C100 concrete can reach 110MPa with the amount of cement 600kg/m3, sand ratio 40% and water cement ratio 0.25.

34 CFR 76.600 - Where to find construction regulations.

Science.gov (United States)

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Where to find construction regulations. 76.600 Section 76.600 Education Office of the Secretary, Department of Education STATE-ADMINISTERED PROGRAMS What Conditions Must Be Met by the State and Its Subgrantees? Construction § 76.600 Where to find construction...

Handbook of energy use for building construction

Energy Technology Data Exchange (ETDEWEB)

Stein, R.G.; Stein, C.; Buckley, M.; Green, M.

1980-03-01

The construction industry accounts for over 11.14% of the total energy consumed in the US annually. This represents the equivalent energy value of 1 1/4 billion barrels of oil. Within the construction industry, new building construction accounts for 5.19% of national annual energy consumption. The remaining 5.95% is distributed among new nonbuilding construction (highways, ralroads, dams, bridges, etc.), building maintenance construction, and nonbuilding maintenance construction. The handbook focuses on new building construction; however, some information for the other parts of the construction industry is also included. The handbook provides building designers with information to determine the energy required for buildings construction and evaluates the energy required for alternative materials, assemblies, and methods. The handbook is also applicable to large-scale planning and policy determination in that it provides the means to estimate the energy required to carry out major building programs.

Handbook of energy use for building construction

Science.gov (United States)

Stein, R. G.; Stein, C.; Buckley, M.; Green, M.

1980-03-01

The construction industry accounts for over 11.14% of the total energy consumed in the US annually. This represents the equivalent energy value of 1 1/4 billion barrels of oil. Within the construction industry, new building construction accounts for 5.19% of national annual energy consumption. The remaining 5.95% is distributed among new nonbuilding construction (highways, railroads, dams, bridges, etc.), building maintenance construction, and nonbuilding maintenance construction. Emphasis is given to new building construction; however, some information for the other parts of the construction industry is also included. Building designers are provided with information to determine the energy required for buildings construction and to evaluate the energy required for alternative materials, assemblies, and methods. It is also applicable to large-scale planning and policy determination in that it provides the means to estimate the energy required to carry out major building programs.

Synthesis of 1,2,4-Triazoles via Oxidative Heterocyclization: Selective C-N Bond Over C-S Bond Formation.

Science.gov (United States)

Gogoi, Anupal; Guin, Srimanta; Rajamanickam, Suresh; Rout, Saroj Kumar; Patel, Bhisma K

2015-09-18

The higher propensity of C-N over C-S bond forming ability was demonstrated, through formal C-H functionalization during the construction of 4,5-disubstituted 1,2,4-triazole-3-thiones from arylidenearylthiosemicarbazides catalyzed by Cu(II). However, steric factors imparted by the o-disubstituted substrates tend to change the reaction path giving thiodiazole as the major or an exclusive product. Upon prolonging the reaction time, the in situ generated thiones are transformed to 4,5-disubstituted 1,2,4-triazoles via a desulfurization process. Two classes of heterocycles viz. 4,5-disubstituted 1,2,4-triazole-3-thiones and 4,5-disubstituted 1,2,4-triazoles can be synthesized from arylidenearylthiosemicarbazides by simply adjusting the reaction time. Desulfurization of 1,2,4-triazole-3-thiones is assisted by thiophilic Cu to provide 1,2,4-triazoles with concomitant formation of CuS and polynuclear sulfur anions as confirmed from scanning electron microscope and energy dispersive X-ray spectroscopy measurements. A one-pot synthesis of an antimicrobial compound has been successfully achieved following this strategy.

A quantum group approach to c{sub L} > 1 Liouville gravity

Energy Technology Data Exchange (ETDEWEB)

Suzuki, Takashi

1995-03-01

A candidate of c{sub L} > 1 Liouville gravity is studied via infinite dimensional representations of U{sub q}sl(2, C) with q at a root of unity. We show that vertex operators in this Liouville theory are factorized into classical vertex operators and those which are constructed from finite dimensional representations of U{sub q}sl(2, C). Expressions of correlation functions and transition amplitudes are presented. We discuss about our results and find an intimate relation between our quantization of the Liouville theory and the geometric quantization of moduli space of Riemann surfaces. An interpretation of quantum space-time is also given within this formulation. (author).

X(3872), IG(JPC) = 0+(1++), as the χc1(2P) charmonium

Science.gov (United States)

Achasov, N. N.; Rogozina, E. V.

2015-09-01

Contrary to almost standard opinion that the X(3872) resonance is the D∗0D¯0 + c.c. molecule or the qcq¯c¯ four-quark state, we discuss the scenario where the X(3872) resonance is the cc¯ = χc1(2P) charmonium which “sits on” the D∗0D¯0 threshold. We explain the shift of the mass of the X(3872) resonance with respect to the prediction of a potential model for the mass of the χc1(2P) charmonium by the contribution of the virtual D∗D¯ + c.c. intermediate states into the self energy of the X(3872) resonance. This allows us to estimate the coupling constant of the X(7872) resonance with the D∗0D¯0 channel, the branching ratio of the X(3872) → D∗0D¯0 + c.c. decay, and the branching ratio of the X(3872) decay into all non-D∗0D¯0 + c.c. states. We predict a significant number of unknown decays of X(3872) via two gluon: X(3872) →gluon gluon →hadrons. We suggest a physically clear program of experimental researches for verification of our assumption.

Toward a constructive physics

International Nuclear Information System (INIS)

Noyes, H.P.; Gefwert, C.; Manthey, M.J.

1983-06-01

We argue that the discretization of physics which has occurred thanks to the advent of quantum mechanics has replaced the continuum standards of time, length and mass which brought physics to maturity by counting. The (arbitrary in the sense of conventional dimensional analysis) standards have been replaced by three dimensional constants: the limiting velocity c, the unit of action h, and either a reference mass (eg m/sub p/) or a coupling constant (eg G related to the mass scale by hc/(2πGm/sub p/ 2 ) approx. = 1.7 x 10 38 ). Once these physical and experimental reference standards are accepted, the conventional approach is to connect physics to mathematics by means of dimensionless ratios. But these standards now rest on counting rather than ratios, and allow us to think of a fourth dimensionless mathematical concept, which is counting integers. According to constructive mathematics, counting has to be understood before engaging in the practice of mathematics in order to avoid redundancy. In its strict form constructive mathematics allows no completed infinities, and must provide finite algorithms for the computation of any acceptable concept. This finite requirement in constructive mathematics is in keeping with the practice of physics when that practice is restricted to hypotheses which are testable in a finite time. In this paper we attempt to outline a program for physics which will meet these rigid criteria while preserving, in so far as possible, the successes that conventional physics has already achieved

Toward a constructive physics

Energy Technology Data Exchange (ETDEWEB)

Noyes, H.P.; Gefwert, C.; Manthey, M.J.

1983-06-01

We argue that the discretization of physics which has occurred thanks to the advent of quantum mechanics has replaced the continuum standards of time, length and mass which brought physics to maturity by counting. The (arbitrary in the sense of conventional dimensional analysis) standards have been replaced by three dimensional constants: the limiting velocity c, the unit of action h, and either a reference mass (eg m/sub p/) or a coupling constant (eg G related to the mass scale by hc/(2..pi..Gm/sub p//sup 2/) approx. = 1.7 x 10/sup 38/). Once these physical and experimental reference standards are accepted, the conventional approach is to connect physics to mathematics by means of dimensionless ratios. But these standards now rest on counting rather than ratios, and allow us to think of a fourth dimensionless mathematical concept, which is counting integers. According to constructive mathematics, counting has to be understood before engaging in the practice of mathematics in order to avoid redundancy. In its strict form constructive mathematics allows no completed infinities, and must provide finite algorithms for the computation of any acceptable concept. This finite requirement in constructive mathematics is in keeping with the practice of physics when that practice is restricted to hypotheses which are testable in a finite time. In this paper we attempt to outline a program for physics which will meet these rigid criteria while preserving, in so far as possible, the successes that conventional physics has already achieved.

MUC1-C integrates PD-L1 induction with repression of immune effectors in non-small-cell lung cancer.

Science.gov (United States)

Bouillez, A; Rajabi, H; Jin, C; Samur, M; Tagde, A; Alam, M; Hiraki, M; Maeda, T; Hu, X; Adeegbe, D; Kharbanda, S; Wong, K-K; Kufe, D

2017-07-13

Immunotherapeutic approaches, particularly programmed death 1/programmed death ligand 1 (PD-1/PD-L1) blockade, have improved the treatment of non-small-cell lung cancer (NSCLC), supporting the premise that evasion of immune destruction is of importance for NSCLC progression. However, the signals responsible for upregulation of PD-L1 in NSCLC cells and whether they are integrated with the regulation of other immune-related genes are not known. Mucin 1 (MUC1) is aberrantly overexpressed in NSCLC, activates the nuclear factor-κB (NF-κB) p65→︀ZEB1 pathway and confers a poor prognosis. The present studies demonstrate that MUC1-C activates PD-L1 expression in NSCLC cells. We show that MUC1-C increases NF-κB p65 occupancy on the CD274/PD-L1 promoter and thereby drives CD274 transcription. Moreover, we demonstrate that MUC1-C-induced activation of NF-κB→︀ZEB1 signaling represses the TLR9 (toll-like receptor 9), IFNG, MCP-1 (monocyte chemoattractant protein-1) and GM-CSF genes, and that this signature is associated with decreases in overall survival. In concert with these results, targeting MUC1-C in NSCLC tumors suppresses PD-L1 and induces these effectors of innate and adaptive immunity. These findings support a previously unrecognized central role for MUC1-C in integrating PD-L1 activation with suppression of immune effectors and poor clinical outcome.

Construction of relativistic quantum theory: a progress report

Energy Technology Data Exchange (ETDEWEB)

Noyes, H.P.

1986-06-01

We construct the particulate states of quantum physics using a recursive computer program that incorporates non-determinism by means of locally arbitrary choices. Quantum numbers and coupling constants arise from the construction via the unique 4-level combinatorial hierarchy. The construction defines indivisible quantum events with the requisite supraluminal correlations, yet does not allow supraluminal communication. Measurement criteria incorporate c, h-bar and m/sub p/ or (not ''and'') G, connected to laboratory events via finite particle number scattering theory and the counter paradigm. The resulting theory is discrete throughout, contains no infinities, and, as far as we have developed it, is in agreement with quantum mechanical and cosmological fact.

[Co-construction of a program to promote community participation among seniors living with psychosocial issues, with or without mental health problems].

Science.gov (United States)

Parisien, Manon; Nour, Kareen; Belley, Anne-Marie; Aubin, Ginette; Billette, Véronique; Dallaire, Bernadette

Objectives A significant proportion of Quebec seniors are living with mental health problems or psychosocial issues such as isolation, bereavement, and psychological distress. These people face many forms of exclusion and are likely to have limited social participation. This paper describes the co-construction steps of a program aimed at promoting community participation among this population.Methods A method for the co-construction of innovative practices in health promotion was used to develop a program that is relevant, rigorous and feasible in diverse settings. The process included several steps, notably: need analysis among seniors and practitioners, development of a logical model for the program, preparation of the leader's manual, validation of the manual by experts, and pilot testing of the program among groups of seniors.Results The goal of the Count me in! program is to promote utilization of the resources of the community that can provide seniors living with mental health conditions or psychosocial issues with activities and positive social contact. The intervention is based on the Strength Model. It includes an individual interview, an eight-meeting workshop, visits to community resources, and collective production of media communication.Conclusion A co-construction process allowed the program to be continuously adjusted in response to stakeholders' feedback. The most important lever for the co-construction was the reconciliation of the partners' practical, conceptual, and experiential expertise. However, contextual factors such as the organization and the availability of mental health services for seniors constituted important barriers to the process.

Psi4 1.1: An Open-Source Electronic Structure Program Emphasizing Automation, Advanced Libraries, and Interoperability.

Science.gov (United States)

Parrish, Robert M; Burns, Lori A; Smith, Daniel G A; Simmonett, Andrew C; DePrince, A Eugene; Hohenstein, Edward G; Bozkaya, Uğur; Sokolov, Alexander Yu; Di Remigio, Roberto; Richard, Ryan M; Gonthier, Jérôme F; James, Andrew M; McAlexander, Harley R; Kumar, Ashutosh; Saitow, Masaaki; Wang, Xiao; Pritchard, Benjamin P; Verma, Prakash; Schaefer, Henry F; Patkowski, Konrad; King, Rollin A; Valeev, Edward F; Evangelista, Francesco A; Turney, Justin M; Crawford, T Daniel; Sherrill, C David

2017-07-11

Psi4 is an ab initio electronic structure program providing methods such as Hartree-Fock, density functional theory, configuration interaction, and coupled-cluster theory. The 1.1 release represents a major update meant to automate complex tasks, such as geometry optimization using complete-basis-set extrapolation or focal-point methods. Conversion of the top-level code to a Python module means that Psi4 can now be used in complex workflows alongside other Python tools. Several new features have been added with the aid of libraries providing easy access to techniques such as density fitting, Cholesky decomposition, and Laplace denominators. The build system has been completely rewritten to simplify interoperability with independent, reusable software components for quantum chemistry. Finally, a wide range of new theoretical methods and analyses have been added to the code base, including functional-group and open-shell symmetry adapted perturbation theory, density-fitted coupled cluster with frozen natural orbitals, orbital-optimized perturbation and coupled-cluster methods (e.g., OO-MP2 and OO-LCCD), density-fitted multiconfigurational self-consistent field, density cumulant functional theory, algebraic-diagrammatic construction excited states, improvements to the geometry optimizer, and the "X2C" approach to relativistic corrections, among many other improvements.

Senescent cells re-engineered to express soluble programmed death receptor-1 for inhibiting programmed death receptor-1/programmed death ligand-1 as a vaccination approach against breast cancer.

Science.gov (United States)

Chen, Zehong; Hu, Kang; Feng, Lieting; Su, Ruxiong; Lai, Nan; Yang, Zike; Kang, Shijun

2018-06-01

Various types of vaccines have been proposed as approaches for prevention or delay of the onset of cancer by boosting the endogenous immune system. We previously developed a senescent-cell-based vaccine, induced by radiation and veliparib, as a preventive and therapeutic tool against triple-negative breast cancer. However, the programmed death receptor-1/programmed death ligand-1 (PD-1/PD-L1) pathway was found to play an important role in vaccine failure. Hence, we further developed soluble programmed death receptor-1 (sPD1)-expressing senescent cells to overcome PD-L1/PD-1-mediated immune suppression while vaccinating to promote dendritic cell (DC) maturity, thereby amplifying T-cell activation. In the present study, sPD1-expressing senescent cells showed a particularly active status characterized by growth arrest and modified immunostimulatory cytokine secretion in vitro. As expected, sPD1-expressing senescent tumor cell vaccine (STCV/sPD-1) treatment attracted more mature DC and fewer exhausted-PD1 + T cells in vivo. During the course of the vaccine studies, we observed greater safety and efficacy for STCV/sPD-1 than for control treatments. STCV/sPD-1 pre-injections provided complete protection from 4T1 tumor challenge in mice. Additionally, the in vivo therapeutic study of mice with s.c. 4T1 tumor showed that STCV/sPD-1 vaccination delayed tumorigenesis and suppressed tumor progression at early stages. These results showed that STCV/sPD-1 effectively induced a strong antitumor immune response against cancer and suggested that it might be a potential strategy for TNBC prevention. © 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

Embedded C Programming Using FRDM to Enhance Engineering Students’ Learning Skill

Directory of Open Access Journals (Sweden)

Zulzilawati Jusoh

2017-08-01

Full Text Available Computer programming course that utilizes languages such as C/C++ is always packed with dreary syntax details that consume most of the students’ learning time to obtain ‘grammatically’ correct source code. Consequently, it is difficult for most of the students to apply the theory they have learned in a real life context. Thus, this project proposed a hardware based learning approach for C programming curriculum and reports the effectiveness of using microcontroller board named FRDM-KL05Z to assist teaching and learning activities. The USB-powered microcontroller board is very easy to use and is programmable using C programming language. Students will have the opportunity to learn selection statement with real sensors, touse repetition statement to blink LEDs and utilizing function as well as structure to control actual input and output peripherals. In general we evaluated the students’ response in five criteria namely the students attributes, lecturer’s profile, implementation, facilities and students’ understanding. From the survey, the results in exit survey are higher compared to entrance survey for all criteria. This shows that the students are satisfied with the implementation of the module which has increased their understanding in learning C Programming.

A software complex intended for constructing applied models and meta-models on the basis of mathematical programming principles

Directory of Open Access Journals (Sweden)

Михаил Юрьевич Чернышов

2013-12-01

Full Text Available A software complex (SC elaborated by the authors on the basis of the language LMPL and representing a software tool intended for synthesis of applied software models and meta-models constructed on the basis of mathematical programming (MP principles is described. LMPL provides for an explicit form of declarative representation of MP-models, presumes automatic constructing and transformation of models and the capability of adding external software packages. The following software versions of the SC have been implemented: 1 a SC intended for representing the process of choosing an optimal hydroelectric power plant model (on the principles of meta-modeling and 2 a SC intended for representing the logic-sense relations between the models of a set of discourse formations in the discourse meta-model.

Practical C++ programming

National Research Council Canada - National Science Library

Oualline, Steve

2003-01-01

... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 4 6 3 2. The Basics of Program Writing Programs from Conception to Execution Creating a Real Program Getting Help in Unix Getting Help in an IDE Programming...

Hemoglobin A1c (HbA1c) Test: MedlinePlus Lab Test Information

Science.gov (United States)

... page: https://medlineplus.gov/labtests/hemoglobina1chba1ctest.html Hemoglobin A1c (HbA1c) Test To use the sharing features on this page, please enable JavaScript. What is a hemoglobin A1c (HbA1c) test? A hemoglobin A1c (HbA1c) test measures ...

The construction of representations of Lie supergroups U(p,q) and C(m,n)

International Nuclear Information System (INIS)

Berezin, F.A.

1977-01-01

The construction of finite-dimensional representations of the Lie supergroups under some general assumptions is given. It is shown that U(p,q) and C(m,n) supergroups satisfy these assumptions. The detailed study of representations of U(p,q) supergroup is given

Electric utility power plant construction costs, 1st Edition

International Nuclear Information System (INIS)

Anon.

1993-01-01

New UDI report combines historical construction costs for more than 1,000 coal, oil, gas, nuclear and geothermal units that have entered commercial operation since 1966 and projected power plant construction costs for about 400 utility-owned generating units scheduled to enter commercial operation during the next 20 years. Key design characteristics and equipment suppliers, A/E, constructor and original installed cost data. Direct construction costs without AFUDC are provided where known. Historical construction cost data are also provided for about 130 utility-owned hydroelectric, gas turbine, combined-cycle and diesel units (these data are generally for units entering service after 1980)

Design and construction of an oscillator with a higly stable frequency

International Nuclear Information System (INIS)

Jardon, A.H.

1978-01-01

An instrument producing pulses with a highly stable frequency was considered necessary for time measurement at the INEN Plasma Physics Program. For this purpose an oscillator with a higly stable frequency which is a measurement instrument was designed and constructed since it can be used as a reference for the measurement of frequency, time, length and phase. The parameters required for this oscillator were as follows: aging lesser than 1 part/10 9 , for sampling period of 0.1 sec.; frequency change equal or smaller than 1 part/10 9 for normal temperature fluctuations found in the laboratory (10 0 C-30 0 C); frequency 1 MHz; amplitude 2 V. After the oscillator was built the parameters were not verified and therefore its characteristics are not exactly known; the reported partial results show that the approximations used for the design are generally valid. (author)

MCSD certification toolkit (exam 70-483) programming in C#

CERN Document Server

Covaci, Tiberiu; Varallo, Vincent; O'Brien, Gerry

2013-01-01

A perfectly crafted prep guide that prepares you for the MCSD 70-483 The MCSD 70-483 exam is the entry-level Microsoft certification exam for C# developers and this must-have resource offers essential coverage of the exam that will test your competency in C# programming. Each chapter covers one of the core subject domains that comprise the exam. Among the authors are experienced trainers who advised Microsoft on the development of its certification programs, affording them a unique understanding of both the objectives and what it takes to master them. This invaluable knowledge is p

Construction and Cloning of Reporter-Tagged Replicon cDNA for an In Vitro Replication Study of Murine Norovirus-1 (MNV-1).

Science.gov (United States)

Ahmad, Muhammad Khairi; Tabana, Yasser M; Ahmed, Mowaffaq Adam; Sandai, Doblin Anak; Mohamed, Rafeezul; Ismail, Ida Shazrina; Zulkiflie, Nurulisa; Yunus, Muhammad Amir

2017-12-01

A norovirus maintains its viability, infectivity and virulence by its ability to replicate. However, the biological mechanisms of the process remain to be explored. In this work, the NanoLuc™ Luciferase gene was used to develop a reporter-tagged replicon system to study norovirus replication. The NanoLuc™ Luciferase reporter protein was engineered to be expressed as a fusion protein for MNV-1 minor capsid protein, VP2. The foot-and-mouth disease virus 2A (FMDV2A) sequence was inserted between the 3'end of the reporter gene and the VP2 start sequence to allow co-translational 'cleavage' of fusion proteins during intracellular transcript expression. Amplification of the fusion gene was performed using a series of standard and overlapping polymerase chain reactions. The resulting amplicon was then cloned into three readily available backbones of MNV-1 cDNA clones. Restriction enzyme analysis indicated that the NanoLucTM Luciferase gene was successfully inserted into the parental MNV-1 cDNA clone. The insertion was further confirmed by using DNA sequencing. NanoLuc™ Luciferase-tagged MNV-1 cDNA clones were successfully engineered. Such clones can be exploited to develop robust experimental assays for in vitro assessments of viral RNA replication.

Mitigation of socio-economic impacts due to the construction of energy projects in rural communities: an evaluation of the Hartsville nuclear power plant transportation-mitigation program

International Nuclear Information System (INIS)

Whitney, T.C.

1982-01-01

This study analyzes the effects of a commuter ride-sharing program in mitigating the harmful socio-economic impacts of a short-term, labor-intensive nuclear-power-plant construction project. The major hypothesis is that transportation-mitigation programs are more cost-effective in reducing the undesirable socio-economic impacts of large-scale construction projects than programs designed to mitigate impacts through the provision of public services for migrating workers. The dissertation begins by delineating the socio-economic effects of large-scale construction projects in rural areas. It proceeds to show how some of the deleterious impacts were mitigated using a commuter ride-sharing program. After the range of potential socio-economic impacts was established, a framework was developed to evaluate the effects of the transportation-mitigation program in mediating the harmful impacts. The framework involved the integration of the cost-benefit technique with social-impact assessment. The evaluation was grounded in a comparative framework whereby the Hartsville project community was compared with a similar community undergoing the construction of a nuclear power plant but without a commuter ride-sharing program, and a community not experiencing a major construction project. The research findings indicated that the transportation-mitigation program substantially reduced the in-migration of construction workers into the Hartsville-Trousdale County area. Further, the program was cost effective, with a benefit-cost ratio of 2.5 and net benefits totalling 28 million dollars

Closed cycle construction: an integrated process for the separation and reuse of C&D waste.

Science.gov (United States)

Mulder, Evert; de Jong, Tako P R; Feenstra, Lourens

2007-01-01

In The Netherlands, construction and demolition (C&D) waste is already to a large extent being reused, especially the stony fraction, which is crushed and reused as a road base material. In order to increase the percentage of reuse of the total C&D waste flow to even higher levels, a new concept has been developed. In this concept, called 'Closed Cycle Construction', the processed materials are being reused at a higher quality level and the quantity of waste that has to be disposed of is minimised. For concrete and masonry, the new concept implies that the material cycle will be completely closed, and the original constituents (clay bricks, gravel, sand, cement stone) are recovered in thermal processes. The mixed C&D waste streams are separated and decontaminated. For this purpose several dry separation techniques are being developed. The quality of the stony fraction is improved so much, that this fraction can be reused as an aggregate in concrete. The new concept has several benefits from a sustainability point of view, namely less energy consumption, less carbon dioxide emission, less waste production and less land use (for excavation and disposal sites). One of the most remarkable benefits of the new concept is that the thermal process steps are fuelled with the combustible fraction of the C&D waste itself. Economically the new process is more or less comparable with the current way of processing C&D waste. On the basis of the positive results of a feasibility study, currently a pilot and demonstration project is being carried out. The aim is to optimise the different process steps of the Closed Cycle Construction process on a laboratory scale, and then to verify them on a large scale. The results of the project are promising, so far.

[Construction and expression of recombinant lentiviral vectors of AKT2,PDK1 and BAD].

Science.gov (United States)

Zhu, Jing; Chen, Bo-Jiang; Huang, Na; Li, Wei-Min

2014-03-01

To construct human protein kinase B (ATK2), phosphoinositide-dependent kinase 1 (PDK1) and bcl-2-associated death protein (BAD) lentiviral expression vector, and to determine their expressions in 293T cells. Total RNA was extracted from lung cancer tissues. The full-length coding regions of human ATK2, BAD and PDK1 cDNA were amplified via RT-PCR using specific primers, subcloned into PGEM-Teasy and then sequenced for confirmation. The full-length coding sequence was cut out with a specific restriction enzyme digest and subclone into pCDF1-MCS2-EF1-copGFP. The plasmids were transfected into 293T cells using the calcium phosphate method. The over expression of AKT2, BAD and PDK1 were detected by Western blot. AKT2, PDK1 and BAD were subcloned into pCDF1-MCS2-EF1-copGFP, with an efficiency of transfection of 100%, 95%, and 90% respectively. The virus titers were 6.7 x 10(6) PFU/mL in the supernatant. After infection, the proteins of AKT2, PDK1 and BAD were detected by Western blot. The lentivial vector pCDF1-MCS2-EF1-copGFP containing AKT2, BAD and PDK1 were successfully constructed and expressed in 293T cells.

The Abbott School Construction Program: Report on the NJ Department of Education Proposed Regulations on Long-Range Facilities Plans

Science.gov (United States)

Ponessa, Joan

2004-01-01

This report on Long Range Facilities Plans (LRFPs) analyzes regulations proposed by the New Jersey Department of Education (NJDOE) to implement the Educational Facilities Construction and Financing Act. (EFCFA). EFCFA, which authorizes and governs New Jersey's public school construction program, was enacted in July 2000 to implement the State…

Construction of a BAC library and identification of Dmrt1 gene of the rice field eel, Monopterus albus

International Nuclear Information System (INIS)

Jang Songhun; Zhou Fang; Xia Laixin; Zhao Wei; Cheng Hanhua; Zhou Rongjia

2006-01-01

A bacterial artificial chromosome (BAC) library was constructed using nuclear DNA from the rice field eel (Monopterus albus). The BAC library consists of a total of 33,000 clones with an average insert size of 115 kb. Based on the rice field eel haploid genome size of 600 Mb, the BAC library is estimated to contain approximately 6.3 genome equivalents and represents 99.8% of the genome of the rice field eel. This is first BAC library constructed from this species. To estimate the possibility of isolating a specific clone, high-density colony hybridization-based library screening was performed using Dmrt1 cDNA of the rice field eel as a probe. Both library screening and PCR identification results revealed three positive BAC clones which were overlapped, and formed a contig covering the Dmrt1 gene of 195 kb. By sequence comparisons with the Dmrt1 cDNA and sequencing of first four intron-exon junctions, Dmrt1 gene of the rice field eel was predicted to contain four introns and five exons. The sizes of first and second intron are 1.5 and 2.6 kb, respectively, and the sizes of last two introns were predicted to be about 20 kb. The Dmrt1 gene structure was conserved in evolution. These results also indicate that the BAC library is a useful resource for BAC contig construction and molecular isolation of functional genes

Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity.

Science.gov (United States)

Lorenz, Sonja; Deng, Patricia; Hantschel, Oliver; Superti-Furga, Giulio; Kuriyan, John

2015-06-01

Constitutive activation of the non-receptor tyrosine kinase c-Abl (cellular Abelson tyrosine protein kinase 1, Abl1) in the Bcr (breakpoint cluster region)-Abl1 fusion oncoprotein is the molecular cause of chronic myeloid leukaemia (CML). Recent studies have indicated that an interaction between the SH2 (Src-homology 2) domain and the N-lobe (N-terminal lobe) of the c-Abl kinase domain (KD) has a critical role in leukaemogenesis [Grebien et al. (2011) Cell 147, 306-319; Sherbenou et al. (2010) Blood 116, 3278-3285]. To dissect the structural basis of this phenomenon, we studied c-Abl constructs comprising the SH2 and KDs in vitro. We present a crystal structure of an SH2-KD construct bound to dasatinib, which contains the relevant interface between the SH2 domain and the N-lobe of the KD. We show that the presence of the SH2 domain enhances kinase activity moderately and that this effect depends on contacts in the SH2/N-lobe interface and is abrogated by specific mutations. Consistently, formation of the interface decreases slightly the association rate of imatinib with the KD. That the effects are small compared with the dramatic in vivo consequences suggests an important function of the SH2-N-lobe interaction might be to help disassemble the auto-inhibited conformation of c-Abl and promote processive phosphorylation, rather than substantially stimulate kinase activity.

Quality during construction

International Nuclear Information System (INIS)

Rogers, C.B.

1977-01-01

This paper outlines the quality assurance program used by Bechtel Corp. in constructing Nuclear Power Plants. As a tool for scheduling and visualizing situations during construction, power plant scale models are used. The use of models, preplanning, detail scheduling, and early development of procedures and inspection plans, have all contributed to a lower cost integrated quality program. Quality control and quality assurance are built in, thus satisfying the regulatory requirements

Prioritization of proposed waste management construction projects for the Waste Management program within the Department of Energy

International Nuclear Information System (INIS)

Johnson, J.V.

1995-01-01

A prioritization process is used to evaluate and rank proposed construction projects within the Department of Energy's Waste Management program. The process is used to determine which projects should proceed with conceptual design activities. The proposed construction projects are evaluated against a set of criteria which reflect Waste Management priorities. A management review team ranks and scores the projects thereby generating a prioritized list of projects. Despite decreasing budgets and changing political climates, the process has been a successful decision-aiding tool for selecting construction projects to carry out the Waste Management mission within the Department of Energy

[Construction of forward and reverse subtracted cDNA libraries between muscle tissue of Meishan and Landrace pigs].

Science.gov (United States)

Xu, De-Quan; Zhang, Yi-Bing; Xiong, Yuan-Zhu; Gui, Jian-Fang; Jiang, Si-Wen; Su, Yu-Hong

2003-07-01

Using suppression subtractive hybridization (SSH) technique, forward and reverse subtracted cDNA libraries were constructed between Longissimus muscles from Meishan and Landrace pigs. A housekeeping gene, G3PDH, was used to estimate the efficiency of subtractive cDNA. In two cDNA libraries, G3PDH was subtracted very efficiently at appropriate 2(10) and 2(5) folds, respectively, indicating that some differentially expressed genes were also enriched at the same folds and the two subtractive cDNA libraries were very successful. A total of 709 and 673 positive clones were isolated from forward and reverse subtracted cDNA libraries, respectively. Analysis of PCR showed that most of all plasmids in the clones contained 150-750 bp inserts. The construction of subtractive cDNA libraries between muscle tissue from different pig breeds laid solid foundations for isolating and identifying the genes determining muscle growth and meat quality, which will be important to understand the mechanism of muscle growth, determination of meat quality and practice of molecular breeding.

Objective-C for Absolute Beginners iPhone and Mac Programming Made Easy

CERN Document Server

Bennett, Gary; Fisher, Mitchell

2010-01-01

It seems as if everyone is writing applications for Apple's iPhone and iPad, but how do they all do it? It's best to learn Objective-C, the native language of both the iOS and Mac OS X, but where to begin? Right here, even if you've never programmed before! Objective-C for Absolute Beginners will teach you how to write software for your Mac, iPhone,or iPad using Objective-C, an elegant and powerful language with a rich set of developer tools. Using a hands-on approach, you'll learn to think in programming terms, how to use Objective-C to build program logic, and how to write your own applicati

All-MXene-Based Integrated Electrode Constructed by Ti3C2 Nanoribbon Framework Host and Nanosheet Interlayer for High-Energy-Density Li-S Batteries.

Science.gov (United States)

Dong, Yanfeng; Zheng, Shuanghao; Qin, Jieqiong; Zhao, Xuejun; Shi, Haodong; Wang, Xiaohui; Chen, Jian; Wu, Zhong-Shuai

2018-03-27

High-energy-density lithium-sulfur (Li-S) batteries hold promise for next-generation portable electronic devices, but are facing great challenges in rational construction of high-performance flexible electrodes and innovative cell configurations for actual applications. Here we demonstrated an all-MXene-based flexible and integrated sulfur cathode, enabled by three-dimensional alkalized Ti 3 C 2 MXene nanoribbon (a-Ti 3 C 2 MNR) frameworks as a S/polysulfides host (a-Ti 3 C 2 -S) and two-dimensional delaminated Ti 3 C 2 MXene (d-Ti 3 C 2 ) nanosheets as interlayer on a polypropylene (PP) separator, for high-energy and long-cycle Li-S batteries. Notably, an a-Ti 3 C 2 MNR framework with open interconnected macropores and an exposed surface area guarantees high S loading and fast ionic diffusion for prompt lithiation/delithiation kinetics, and the 2D d-Ti 3 C 2 MXene interlayer remarkably prevents the shuttle effect of lithium polysulfides via both chemical absorption and physical blocking. As a result, the integrated a-Ti 3 C 2 -S/d-Ti 3 C 2 /PP electrode was directly used for Li-S batteries, without the requirement of a metal current collector, and exhibited a high reversible capacity of 1062 mAh g -1 at 0.2 C and enhanced capacity of 632 mAh g -1 after 50 cycles at 0.5 C, outperforming the a-Ti 3 C 2 -S/PP electrode (547 mAh g -1 ) and conventional a-Ti 3 C 2 -S on an Al current collector (a-Ti 3 C 2 -S/Al) (597 mAh g -1 ). Furthermore, the all-MXene-based integrated cathode displayed outstanding rate capacity of 288 mAh g -1 at 10 C and long-life cyclability. Therefore, this proposed strategy of constructing an all-MXene-based cathode can be readily extended to assemble a large number of MXene-derived materials, from a group of 60+ MAX phases, for applications such as various batteries and supercapacitors.

Construction labor productivity during nuclear power plant construction

International Nuclear Information System (INIS)

Murray, W.B.

1980-01-01

This paper discusses the three different types of productivity programs used at the Wm. H. Zimmer Nuclear Power Station construction site. The Standard Cost Estimate as Productivity Measurement compares actual units installed to estimated units. The Manpower and Equipment Utilization Study measures the present utilization level of the construction work force, identifies opportunities for productivity improvement, and establishes a data base against which future improvements could be made. The special productivity program is a specialized and detailed study of first line supervision. Productivity is defined as the degree of efficiency attained in the use of labor, professional and management skills and knowledge, materials and equipment, and time and money to produce an end result. It is concluded that a more consistent system of productivity measurements needs to be developed and promoted for general use in the construction industry

324 and 325 Building hot cell cleanout program: Decontamination of C-Cell

International Nuclear Information System (INIS)

Katayama, Y.B.; Holton, L.K. Jr.

1989-10-01

During FY 1989 the decontamination of C-Cell of Hanford's 324 Building was completed as part of the 324 and 325 Building Hot Cell Cleanout Program sponsored by the DOE Nuclear Energy's Surplus Facilities Management Program. The decontamination effort was completed using a series of remote and contact decontamination techniques. Initial radiation readings in C-Cell averaged 50 rad/hr and were reduced remotely to less than 200 mrad/hr using an alkaline foam cleaner followed by a 5000-psi water flush. Contact decontamination was then permissible using ultra high-pressure water, at 36,000 psi, further reducing the average radiation level in the cell to less than 86 mrem/hr. The approach used in decontaminating C-Cell resulted in a savings in radiation exposure of 87% and a cost savings of 39% compared to a hands-on procedure used in A-Cell, 324 Building in 1987. The radiation dose and the costs to achieve a 244-fold reduction in radiation contamination were 1.65 mrem per ft 2 and $96 per ft 2 of cell surface area. 14 figs., 4 tabs

Real-Time MENTAT programming language and architecture

Science.gov (United States)

Grimshaw, Andrew S.; Silberman, Ami; Liu, Jane W. S.

1989-01-01

Real-time MENTAT, a programming environment designed to simplify the task of programming real-time applications in distributed and parallel environments, is described. It is based on the same data-driven computation model and object-oriented programming paradigm as MENTAT. It provides an easy-to-use mechanism to exploit parallelism, language constructs for the expression and enforcement of timing constraints, and run-time support for scheduling and exciting real-time programs. The real-time MENTAT programming language is an extended C++. The extensions are added to facilitate automatic detection of data flow and generation of data flow graphs, to express the timing constraints of individual granules of computation, and to provide scheduling directives for the runtime system. A high-level view of the real-time MENTAT system architecture and programming language constructs is provided.

HTR-PROTEUS pebble bed experimental program cores 9 & 10: columnar hexagonal point-on-point packing with a 1:1 moderator-to-fuel pebble ratio

Energy Technology Data Exchange (ETDEWEB)

Bess, John D. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2014-03-01

PROTEUS is a zero-power research reactor based on a cylindrical graphite annulus with a central cylindrical cavity. The graphite annulus remains basically the same for all experimental programs, but the contents of the central cavity are changed according to the type of reactor being investigated. Through most of its service history, PROTEUS has represented light-water reactors, but from 1992 to 1996 PROTEUS was configured as a pebble-bed reactor (PBR) critical facility and designated as HTR-PROTEUS. The nomenclature was used to indicate that this series consisted of High Temperature Reactor experiments performed in the PROTEUS assembly. During this period, seventeen critical configurations were assembled and various reactor physics experiments were conducted. These experiments included measurements of criticality, differential and integral control rod and safety rod worths, kinetics, reaction rates, water ingress effects, and small sample reactivity effects (Ref. 3). HTR-PROTEUS was constructed, and the experimental program was conducted, for the purpose of providing experimental benchmark data for assessment of reactor physics computer codes. Considerable effort was devoted to benchmark calculations as a part of the HTR-PROTEUS program. References 1 and 2 provide detailed data for use in constructing models for codes to be assessed. Reference 3 is a comprehensive summary of the HTR-PROTEUS experiments and the associated benchmark program. This document draws freely from these references. Only Cores 9 and 10 are evaluated in this benchmark report due to similarities in their construction. The other core configurations of the HTR-PROTEUS program are evaluated in their respective reports as outlined in Section 1.0. Cores 9 and 10 were evaluated and determined to be acceptable benchmark experiments.

HTR-PROTEUS PEBBLE BED EXPERIMENTAL PROGRAM CORES 9 & 10: COLUMNAR HEXAGONAL POINT-ON-POINT PACKING WITH A 1:1 MODERATOR-TO-FUEL PEBBLE RATIO

Energy Technology Data Exchange (ETDEWEB)

John D. Bess

2013-03-01

PROTEUS is a zero-power research reactor based on a cylindrical graphite annulus with a central cylindrical cavity. The graphite annulus remains basically the same for all experimental programs, but the contents of the central cavity are changed according to the type of reactor being investigated. Through most of its service history, PROTEUS has represented light-water reactors, but from 1992 to 1996 PROTEUS was configured as a pebble-bed reactor (PBR) critical facility and designated as HTR-PROTEUS. The nomenclature was used to indicate that this series consisted of High Temperature Reactor experiments performed in the PROTEUS assembly. During this period, seventeen critical configurations were assembled and various reactor physics experiments were conducted. These experiments included measurements of criticality, differential and integral control rod and safety rod worths, kinetics, reaction rates, water ingress effects, and small sample reactivity effects (Ref. 3). HTR-PROTEUS was constructed, and the experimental program was conducted, for the purpose of providing experimental benchmark data for assessment of reactor physics computer codes. Considerable effort was devoted to benchmark calculations as a part of the HTR-PROTEUS program. References 1 and 2 provide detailed data for use in constructing models for codes to be assessed. Reference 3 is a comprehensive summary of the HTR-PROTEUS experiments and the associated benchmark program. This document draws freely from these references. Only Cores 9 and 10 are evaluated in this benchmark report due to similarities in their construction. The other core configurations of the HTR-PROTEUS program are evaluated in their respective reports as outlined in Section 1.0. Cores 9 and 10 were evaluated and determined to be acceptable benchmark experiments.

Hazing DEOCS 4.1 Construct Validity Summary

Science.gov (United States)

2017-08-01

Hazing DEOCS 4.1 Construct Validity Summary DEFENSE EQUAL OPPORTUNITY MANAGEMENT INSTITUTE DIRECTORATE OF...water; and the forced consumption of food , alcohol, drugs, or any other substance. Hazing can be conducted through the use of electronic devices or

Pharmacist-led, primary care-based disease management improves hemoglobin A1c in high-risk patients with diabetes.

Science.gov (United States)

Rothman, Russell; Malone, Robb; Bryant, Betsy; Horlen, Cheryl; Pignone, Michael

2003-01-01

We developed and evaluated a comprehensive pharmacist-led, primary care-based diabetes disease management program for patients with Type 2 diabetes and poor glucose control at our academic general internal medicine practice. The primary goal of this program was to improve glucose control, as measured by hemoglobin A1c (HbA1c). Clinic-based pharmacists offered support to patients with diabetes through direct teaching about diabetes, frequent phone follow-up, medication algorithms, and use of a database that tracked patient outcomes and actively identified opportunities to improve care. From September 1999, to May 2000, 159 subjects were enrolled, and complete follow-up data were available for 138 (87%) patients. Baseline HbA1c averaged 10.8%, and after an average of 6 months of intervention, the mean reduction in HbA1c was 1.9 percentage points (95% confidence interval, 1.5-2.3). In predictive regression modeling, baseline HbA1c and new onset diabetes were associated with significant improvements in HbA1c. Age, race, gender, educational level, and provider status were not significant predictors of improvement. In conclusion, a pharmacist-based diabetes care program integrated into primary care practice significantly reduced HbA1c among patients with diabetes and poor glucose control.

Development of C++ Application Program for Solving Quadratic Equation in Elementary School in Nigeria

Science.gov (United States)

Bandele, Samuel Oye; Adekunle, Adeyemi Suraju

2015-01-01

The study was conducted to design, develop and test a c++ application program CAP-QUAD for solving quadratic equation in elementary school in Nigeria. The package was developed in c++ using object-oriented programming language, other computer program that were also utilized during the development process is DevC++ compiler, it was used for…

Dicty_cDB: VHI596 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available 295 |pid:none) Pongo abelii mRNA; cDNA DKFZp469L1... 62 9e-09 BC114006_1( BC114006 |pid:none) Bos taurus L-pipecoli...one) Synthetic construct Homo sapiens c... 61 2e-08 BC027622_1( BC027622 |pid:none) Homo sapiens pipecolic a

Bullying DEOCS 4.1 Construct Validity Summary

Science.gov (United States)

2017-08-01

Bullying DEOCS 4.1 Construct Validity Summary DEFENSE EQUAL OPPORTUNITY MANAGEMENT INSTITUTE DIRECTORATE OF...excessive or abusive use of water; the forced consumption of food , alcohol, drugs, or any other substance; and degrading or damaging the person or his

Sugawara construction for affine SL(N,1)

International Nuclear Information System (INIS)

Henningson, M.

1990-01-01

We investigate the sl(N,1) superalgebras, their affine extensions and their representations. This is used to perform a Sugawara construction of the Virasoro algebra. The allowed values of the conformal anomaly and the conformal dimension are computed. (orig.)

"1"3CO/C"1"8O Gradients across the Disks of Nearby Spiral Galaxies

International Nuclear Information System (INIS)

Jiménez-Donaire, María J.; Cormier, Diane; Bigiel, Frank; Leroy, Adam K.; Gallagher, Molly; Krumholz, Mark R.; Usero, Antonio; Hughes, Annie; Kramer, Carsten; Meier, David; Murphy, Eric; Pety, Jérôme; Schuster, Karl; Schinnerer, Eva; Sliwa, Kazimierz; Tomicic, Neven; Schruba, Andreas

2017-01-01

We use the IRAM Large Program EMPIRE and new high-resolution ALMA data to measure "1"3CO(1-0)/C"1"8O(1-0) intensity ratios across nine nearby spiral galaxies. These isotopologues of "1"2CO are typically optically thin across most of the area in galaxy disks, and this ratio allows us to gauge their relative abundance due to chemistry or stellar nucleosynthesis effects. Resolved "1"3CO/C"1"8O gradients across normal galaxies have been rare due to the faintness of these lines. We find a mean "1"3CO/C"1"8O ratio of 6.0 ± 0.9 for the central regions of our galaxies. This agrees well with results in the Milky Way, but differs from results for starburst galaxies (3.4 ± 0.9) and ultraluminous infrared galaxies (1.1 ± 0.4). In our sample, the "1"3CO/C"1"8O ratio consistently increases with increasing galactocentric radius and decreases with increasing star formation rate surface density. These trends could be explained if the isotopic abundances are altered by fractionation; the sense of the trends also agrees with those expected for carbon and oxygen isotopic abundance variations due to selective enrichment by massive stars.

Construction and immunogenicity of replication-competent adenovirus 5 host range mutant recombinants expressing HIV-1 gp160 of SF162 and TV1 strains.

Science.gov (United States)

Hidajat, Rachmat; Kuate, Seraphin; Venzon, David; Kalyanaraman, Vaniambadi; Kalisz, Irene; Treece, James; Lian, Ying; Barnett, Susan W; Robert-Guroff, Marjorie

2010-05-21

An HIV Env immunogen capable of eliciting broad immunity is critical for a successful vaccine. We constructed and characterized adenovirus 5 host range mutant (Ad5hr) recombinants encoding HIV(SF162) gp160 (subtype B) and HIV(TV1) gp160 (subtype C). Immunization of mice with one or both induced cellular immunity to subtype B and C peptides by ELISpot, and antibody responses with high binding titers to HIV Env of subtypes A, B, C, and E. Notably, Ad5hr-HIV(TV1) gp160 induced better cellular immunity than Ad5hr-HIV(SF162) gp160, either alone or following co-administration. Thus, the TV1 Env recombinant alone may be sufficient for eliciting immune responses against both subtype B and C envelopes. Further studies of Ad5hr-HIV(TV1) gp160 in rhesus macaques will evaluate the suitability of this insert for a future phase I clinical trial using a replication-competent Ad4 vector. Published by Elsevier Ltd.

DNA vaccine expressing herpes simplex virus 1 glycoprotein C and D protects mice against herpes simplex keratitis

OpenAIRE

Li-Li Dong; Ru Tang; Yu-Jia Zhai; Tejsu Malla; Kai Hu

2017-01-01

AIM: To investigate whether DNA vaccine encoding herpes simplex virus 1 (HSV-1) glycoprotein C (gC) and glycoprotein D (gD) will achieve better protective effect against herpes simplex keratitis (HSK) than DNA vaccine encoding gD alone. METHODS: DNA vaccine expressing gD or gC combined gD (gD.gC) were constructed and carried by chitosan nanoparticle. The expression of fusion protein gD and gC were detected in DNA/nanoparticle transfected 293T cells by Western-blot. For immunization, mice w...

Constructive tensorial group field theory II: the {U(1)-T^4_4} model

Science.gov (United States)

Lahoche, Vincent

2018-05-01

In this paper, we continue our program of non-pertubative constructions of tensorial group field theories (TGFT). We prove analyticity and Borel summability in a suitable domain of the coupling constant of the simplest super-renormalizable TGFT which contains some ultraviolet divergencies, namely the color-symmetric quartic melonic rank-four model with Abelian gauge invariance, nicknamed . We use a multiscale loop vertex expansion. It is an extension of the loop vertex expansion (the basic constructive technique for non-local theories) which is required for theories that involve non-trivial renormalization.

Secure Programming Cookbook for C and C++ Recipes for Cryptography, Authentication, Input Validation & More

CERN Document Server

Viega, John

2009-01-01

Secure Programming Cookbook for C and C++ is an important new resource for developers serious about writing secure code for Unix® (including Linux®) and Windows® environments. This essential code companion covers a wide range of topics, including safe initialization, access control, input validation, symmetric and public key cryptography, cryptographic hashes and MACs, authentication and key exchange, PKI, random numbers, and anti-tampering.

Tank 241-TX-302C grab samples 302C-TX-97-1A through 302C-TX-97-3B analytical results for the final report

Energy Technology Data Exchange (ETDEWEB)

Esch, R.A.

1998-03-12

This document is the final report for tank 241-TX-302C grab samples. Six grabs samples (302C-TX-97-1A, 302C-TX-97-1B, 302C-TX-97-2A, 302C-TX-97-2B, 302C-TX-97-3A, and 302C-TX-97-3B) were collected from the catch tank level gauge riser on December 19, 1997. The ``A`` and ``B`` portions from each sample location were composited and analyses were performed on the composites in accordance with the Compatibility Grab Sampling and Analysis Plan (TSAP) (Sasaki, 1997) and the Data Quality Objectives for Tank Farms Waste Compatibility Program (DQO) (Rev. 1: Fowler, 1995; Rev. 2: Mulkey and Miller, 1997). The analytical results are presented in Table 1. No notification limits were exceeded. Appearance and Sample Handling Attachment 1 is provided as a cross-reference for relating the tank farm customer identification numbers with the 222-S Laboratory sample numbers and the portion of sample analyzed. Table 2 provides the appearance information.

Tank 241-TX-302C grab samples, 302C-TX-97-1A through 302C-TX-97-3B analytical results for the final report

International Nuclear Information System (INIS)

Esch, R.A.

1998-01-01

This document is the final report for tank 241-TX-302C grab samples. Six grabs samples (302C-TX-97-1A, 302C-TX-97-1B, 302C-TX-97-2A, 302C-TX-97-2B, 302C-TX-97-3A, and 302C-TX-97-3B) were collected from the catch tank level gauge riser on December 19, 1997. The ''A'' and ''B'' portions from each sample location were composited and analyses were performed on the composites in accordance with the Compatibility Grab Sampling and Analysis Plan (TSAP) (Sasaki, 1997) and the Data Quality Objectives for Tank Farms Waste Compatibility Program (DQO) (Rev. 1: Fowler, 1995; Rev. 2: Mulkey and Miller, 1997). The analytical results are presented in Table 1. No notification limits were exceeded. Appearance and Sample Handling Attachment 1 is provided as a cross-reference for relating the tank farm customer identification numbers with the 222-S Laboratory sample numbers and the portion of sample analyzed. Table 2 provides the appearance information

The Long and Winding Road to Optimal HbA1c Measurement

Science.gov (United States)

Little, Randie R.; Rohlfing, Curt

2016-01-01

The importance of hemoglobin A1c (HbA1c) as an indicator of mean glycemia and risks for complications in patients with diabetes mellitus was established by the results of long-term clinical trials, most notably the Diabetes Control and Complications Trial (DCCT) and United Kingdom Prospective Diabetes Study (UKPDS), published in 1993 and 1998 respectively. However, clinical application of recommended HbA1c targets that were based on these studies was difficult due to lack of comparability of HbA1c results among assay methods and laboratories. Thus, the National Glycohemoglobin Standardization Program (NGSP) was initiated in 1996 with the goal of standardizing HbA1c results to those of the DCCT/UKPDS. HbA1c standardization efforts have been highly successful; however, a number of issues have emerged on the “long and winding road” to better HbA1c, including the development of a higher-order HbA1c reference method by the International Federation of Clinical Chemistry (IFCC), recommendations to use HbA1c to diagnose as well as monitor diabetes, and point-of-care (POC) HbA1c testing. Here, we review the past, present and future of HbA1c standardization and describe the current status of HbA1c testing, including limitations that healthcare providers need to be aware of when interpreting HbA1c results. PMID:23318564

Semiannual progress report for the Idaho Geothermal Program, April 1--September 30, 1978

Energy Technology Data Exchange (ETDEWEB)

Blake, G.L. (ed.)

1978-11-01

Research and development performed by the Idaho Geothermal Program between April 1 and September 30, 1978 are discussed. Well drilling and facility construction at the Raft River geothermal site are described. Efforts to understand the geothermal reservoir are explained, and attempts to predict the wells' potential are summarized. Investigations into the direct uses of geothermal water, such as for industrial drying, fish farming, and crop irrigation, are reported. The operation of the facility's first electrical generator is described. Construction of the first 5-megawatt power plant is recounted. The design effort for the second pilot power plant is also described. University of Utah work with direct-contact heat exchangers is outlined. Special environmental studies of injection tests, ferruginous hawks, and dental fluorisis are summarized. The regional planning effort for accelerated commercialization is described. Demonstration projects in Oregon, Utah, and South Dakota are noted. A bibliographical appendix lists each internal and external report the Idaho Geothermal Program has published since its beginning in 1973.

Process evaluation of a Toolbox-training program for construction foremen in Denmark

DEFF Research Database (Denmark)

Jeschke, Katharina Christiane; Kines, Pete; Rasmussen, Liselotte

2017-01-01

foremen’s knowledge and communication skills in daily planning of work tasks and their related OSH risks on construction sites. The program builds on the popular 'toolbox meeting' concept, however there is very little research evaluating these types of meetings. This article describes the development...... and revised until the final version after the fifth group. The evaluation utilized an action research strategy with a mixed–methods approach of triangulating questionnaire, interview, and observation data. Process evaluation results showed that the eight Toolbox-training topics were relevant and useful...

42 CFR 137.410 - For the purposes of section 110 of the Act [25 U.S.C. 450m-1] does the term contract include...

Science.gov (United States)

2010-10-01

....C. 450m-1] does the term contract include compacts, funding agreements, and construction project... the term contract include compacts, funding agreements, and construction project agreements entered into under Title V? Yes, for the purposes of section 110 of the Act [25 U.S.C. 450m-1] the term...

Modular construction approach for advanced nuclear plants

International Nuclear Information System (INIS)

Johnson, F.T.; Orr, R.S.; Boudreaux, C.P.

1988-01-01

Modular construction has been designated as one of the major features of the AP600 program, a small innovative 600-MW (electric) advanced light water reactor (ALWR) that is currently being developed by Westinghouse and its subcontractors. This program is sponsored by the US Department of Energy (DOE) in conjunction with several other DOE and Electric Power Research Institute ALWR programs. Two major objectives of the AP600 program are as follows: (1) to provide a cost of power competitive with other power generation alternatives; and (2) to provide a short construction schedule that can be met with a high degree of certainty. The AP600 plant addresses these objectives by providing a simplified plant design and an optimized plant arrangement that result in a significant reduction in the number and size of systems and components, minimizes the overall building volumes, and consequently reduces the required bulk quantities. However, only by adopting a modular construction approach for the AP600 can the full cost and schedule benefits be realized from the advances made in the plant systems design and plant arrangement. Modularization is instrumental in achieving both of the above objectives, but most of all, a total modularization approach is considered absolutely essential to ensure that an aggressive construction schedule can be met with a high degree of certainty

Nevada Test Site Radiation Protection Program - Revision 1

International Nuclear Information System (INIS)

Nevada Test Site Radiological Control Managers' Council

2008-01-01

Title 10 Code of Federal Regulations (CFR) Part 835, 'Occupational Radiation Protection,' establishes radiation protection standards, limits, and program requirements for protecting individuals from ionizing radiation resulting from the conduct of U.S. Department of Energy (DOE) activities. 10 CFR 835.101(a) mandates that DOE activities be conducted in compliance with a documented Radiation Protection Program (RPP) as approved by DOE. This document promulgates the RPP for the Nevada Test Site (NTS), related (on-site or off-site) U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) operations, and environmental restoration off-site projects. This NTS RPP promulgates the radiation protection standards, limits, and program requirements for occupational exposure to ionizing radiation resulting from NNSA/NSO activities at the NTS and other operational areas as stated in 10 CFR 835.1(a). NNSA/NSO activities (including design, construction, operation, and decommissioning) within the scope of this RPP may result in occupational exposures to radiation or radioactive material. Therefore, a system of control is implemented through specific references to the site-specific NV/YMP RCM. This system of control is intended to ensure that the following criteria are met: (1) occupational exposures are maintained as low as reasonably achievable (ALARA), (2) DOE's limiting values are not exceeded, (3) employees are aware of and are prepared to cope with emergency conditions, and (4) employees are not inadvertently exposed to radiation or radioactive material

Nevada Test Site Radiation Protection Program - Revision 1

Energy Technology Data Exchange (ETDEWEB)

Radiological Control Managers' Council

2008-06-01

Title 10 Code of Federal Regulations (CFR) Part 835, 'Occupational Radiation Protection,' establishes radiation protection standards, limits, and program requirements for protecting individuals from ionizing radiation resulting from the conduct of U.S. Department of Energy (DOE) activities. 10 CFR 835.101(a) mandates that DOE activities be conducted in compliance with a documented Radiation Protection Program (RPP) as approved by DOE. This document promulgates the RPP for the Nevada Test Site (NTS), related (on-site or off-site) U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) operations, and environmental restoration off-site projects. This NTS RPP promulgates the radiation protection standards, limits, and program requirements for occupational exposure to ionizing radiation resulting from NNSA/NSO activities at the NTS and other operational areas as stated in 10 CFR 835.1(a). NNSA/NSO activities (including design, construction, operation, and decommissioning) within the scope of this RPP may result in occupational exposures to radiation or radioactive material. Therefore, a system of control is implemented through specific references to the site-specific NV/YMP RCM. This system of control is intended to ensure that the following criteria are met: (1) occupational exposures are maintained as low as reasonably achievable (ALARA), (2) DOE's limiting values are not exceeded, (3) employees are aware of and are prepared to cope with emergency conditions, and (4) employees are not inadvertently exposed to radiation or radioactive material.

Synthesis and biological activity of fused tetracyclic Pyrrolo[2,1-c][1,4]benzodiazepines

Directory of Open Access Journals (Sweden)

Joel K. Annor-Gyamfi

2018-02-01

Full Text Available Cancer remains the second major cause of death in the world. Thus, there is a pressing need to identify potential synthetic route for the development of novel anticancer agents which will serve as lead compounds to effectively combat this life-threatening epidemic. Pyrrolo[2,1-c][1,4]benzodiazepines (PBDs have sparked a great interest as lead compounds because of their cancerostatic and anti-infective properties. The twisted molecular structure of PBD analogs provides both helical and chiral elements. In an effort to expand novel PBDs that interact with the key exocyclic amino group of the DNA-guanine base, we hypothesized that construction of a fused cyclic active system, would likely serve as an electrophilic site when compared to traditional electrophilic C11-N10 imine group. To examine our theory, we report herein the synthesis and cell viability/cytotoxicity of a series of PBD analogs using NCI-60 cell lines screening. Thus, compounds 1–13 were synthesized and fully characterized. The selected PBDs were found to have marginal inhibition of growth, up to 30%, for certain cell lines.

Life cycle assessment of construction and demolition waste management

DEFF Research Database (Denmark)

Butera, Stefania; Christensen, Thomas Højlund; Astrup, Thomas Fruergaard

2015-01-01

Life cycle assessment (LCA) modelling of construction and demolition waste (C&DW) management was carried out. The functional unit was management of 1 Mg mineral, source separated C&DW, which is either utilised in road construction as a substitute for natural aggregates, or landfilled. The assessed...... of the use of C&DW. Typical uncertainties related to contaminant leaching were addressed. For most impact categories, utilisation of C&DW in road construction was preferable to landfilling; however, for most categories, utilisation resulted in net environmental burdens. Transportation represented the most...... of the impact assessment was critical for modelling the leaching impacts. Compared with the overall life cycle of building and construction materials, leaching emissions were shown to be potentially significant for toxicity impacts, compared with contributions from production of the same materials, showing...

Design and construction of automatic operating system of double chamber plasma nitriding device PLC based

International Nuclear Information System (INIS)

Saminto; Slamet Santosa; Eko Priyono

2012-01-01

The automatic operating system of double chamber plasma nitriding device has been done. The system is used for operating double chamber plasma nitriding automatically as according to the standard operating procedure by pressing push button on the human machine interface (HMI). The system consists of hardware and software. The hardware was constructed using main components T100MD1616+ PLC module and supported by temperature signal conditioner module, Wheatstone bridge module, isolated amplifier module and EMS 30A H Bridge motor driver module. A software program that is planted on T100MD1616+ PLC using ladder diagrams and Tbasic program. Test system functions performed by inserting a set values of temperature and pressure by pressing the button on the human machine interface (HMI). The test results show that the temperature control with a set of values 100 °C obtained stable coverage of 98 °C to 102 °C, (Δ ± 2 °C) with a 2% tolerance and the output voltage of the DAC is 2.436 volts to 2.913 volts. The pressure control with a set of values 2.169 x 10 -1 mbar obtained stable coverage of 1.995 x 10 -1 mbar to 2.205 x 10 -1 mbar, (Δ ± 0.105 x 10 -1 mbar) with a 5% tol. (author)

Soluble Programmed Death 1 (PD-1) Is Decreased in Patients With Immune Thrombocytopenia (ITP): Potential Involvement of PD-1 Pathway in ITP Immunopathogenesis.

Science.gov (United States)

Birtas Atesoglu, Elif; Tarkun, Pinar; Demirsoy, Esra Terzi; Geduk, Ayfer; Mehtap, Ozgur; Batman, Adnan; Kaya, Fatih; Cekmen, Mustafa Baki; Gulbas, Zafer; Hacıhanefioglu, Abdullah

2016-04-01

Immune thrombocytopenia (ITP) is an autoimmune disease characterized by dysregulation of T cells. Programmed death (PD) 1 and programmed death 1 ligand 1 (PD-L1) are cosignaling molecules, and the major role of the PD-1 pathway is the inhibition of self-reactive T cells and to protect against autoimmune diseases. We measured levels of serum soluble PD 1 (sPD-1) and serum soluble PD-L1 (sPD-L1) in 67 patients with ITP (24 newly diagnosed ITP [ndITP], 43 chronic ITP [cITP]) and 21 healthy controls (HCs). We determined decreased serum sPD-1 levels both in patients with ndITP and in patients with cITP when compared to HC. Moreover, there was a positive correlation between sPD-1 levels and platelet counts. The sPD-L1 levels were decreased in patients with ndITP when compared to patients with cITP. This is the first study investigating PD-1 signaling pathway in ITP. Decreased sPD-1 levels may have a role in ITP pathogenesis as without the inhibitory regulation of PD-1, sustained activation of T cells may cause inflammatory responses which is the case in ITP. © The Author(s) 2014.

Construction and Demolition Waste

DEFF Research Database (Denmark)

Christensen, Thomas Højlund; Andersen, L.

2011-01-01

Construction and demolition waste (C&D waste) is the waste generated during the building, repair, remodeling or removal of constructions. The constructions can be roads, residential housing and nonresidential buildings. C&D waste has traditionally been considered without any environmental problems...... should be managed accordingly. Another reason is that it has been documented that a large fraction of C&D waste (about 90 %) can be easily recycled and thus can conserve landfill capacity. C&D waste may conveniently be divided into three subcategories: Buildings, roads and excavations. This chapter...

Programming 16-Bit PIC Microcontrollers in C Learning to Fly the PIC 24

CERN Document Server

Di Jasio, Lucio

2011-01-01

New in the second edition: * MPLAB X support and MPLAB C for the PIC24F v3 and later libraries * I2C™ interface * 100% assembly free solutions * Improved video, PAL/NTSC * Improved audio, RIFF files decoding * PIC24F GA1, GA2, GB1 and GB2 support   Most readers will associate Microchip's name with the ubiquitous 8-bit PIC microcontrollers but it is the new 16-bit PIC24F family that is truly stealing the scene. Orders of magnitude increases of performance, memory size and the rich peripheral set make programming these devices in C a must. This new guide by Microchip insid

LEAR construction completed

CERN Multimedia

CERN PhotoLab

1982-01-01

In July 1982, LEAR construction was completed, the individual systems had been dry-tested. On 16 July, the first 50 MeV (309 MeV/c) protons from Linac 1 were injected and circulated. On 11 October, the first antiprotons from the AA, decelerated in the PS to 609 MeV/c, were injected. Also in 1982, acceleration, deceleration and stochastic cooling were successfully tested. See 9007366 for a more detailed description. See also 8201061, 8204131, 8309026.

Stirling Space Engine Program. Volume 2; Appendixes A, B, C and D

Science.gov (United States)

Dhar, Manmohan

1999-01-01

The objective of this program was to develop the technology necessary for operating Stirling power converters in a space environment and to demonstrate this technology in full-scale engine tests. Volume 2 of the report includes the following appendices: Appendix A: Heater Head Development (Starfish Heater Head Program, 1/10th Segment and Full-Scale Heat Pipes, and Sodium Filling and Processing); Appendix B: Component Test Power Converter (CTPC) Component Development (High-temperature Organic Materials, Heat Exchanger Fabrication, Beryllium Issues, Sodium Issues, Wear Couple Tests, Pressure Boundary Penetrations, Heating System Heaters, and Cooler Flow Test); Appendix C: Udimet Testing (Selection of the Reference Material for the Space Stirling Engine Heater Head, Udimet 720LI Creep Test Result Update, Final Summary of Space Stirling Endurance Engine Udimet 720L1 Fatigue Testing Results, Udimet 720l1 Weld Development Summary, and Udimet 720L1 Creep Test Final Results Summary), and Appendix D: CTPC Component Development Photos.

Association of -31T>C and -511 C>T polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients.

Science.gov (United States)

Kim, So-Hee; Mok, Jee-Won; Kim, Hyun-Seok; Joo, C K

2008-01-01

To investigate the genetic association between unrelated Korean keratoconus patients and interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and IL1 receptor antagonist (IL1RN) gene polymorphisms. We investigated the association between IL1A (rs1800587, rs2071376, and rs17561), IL1B (rs1143627, rs16944, rs1143634, and rs1143633), and IL1RN (rs419598, rs423904, rs424078, and rs315952, variable number tandem repeat [VNTR]) polymorphisms in 100 unrelated Korean keratoconus patients. One hundred control individuals without any corneal disease were selected from the general population. Polymerase chain reaction (PCR) - restriction fragment length polymorphism (RFLP) analysis and direct sequencing were used to screen for genetic variations in the IL1 gene cluster. Haplotypes for the IL1 gene cluster were constructed using Haploview version 4.0. We analyzed a total of 12 polymorphic sites in the IL1 gene cluster. Among them, the -511 (rs16944) and -31 (rs1143627) positions in the promoter region of IL1B were significantly different between patient and control groups. The C allele of rs16944 (-511C>T, p=0.022, odds ratio of risk [OR]=1.46, 95% confidence intervals [CI] 0.94C, p=0.025, OR=1.43, 95% CI 0.92<2.22) were associated with a significantly increased risk of keratoconus in Korean patients. Linkage of the two alleles, -31*C and -511*T, was associated with an increased risk for keratoconus with OR=2.38 (p=0.012, 95% CI=1.116-5.046). The *C/*A genotype of rs2071376 in IL1A intron 6 was significantly different between the keratoconus patients and control subjects (p=0.034, OR=0.59, 95% CI 0.32<1.11). Other polymorphisms did not show an association with keratoconus risk. This is the first report of IL1 gene cluster mutation screening in Korean keratoconus patients. Significant differences in allelic frequency of IL1B between keratoconus patients and the control group suggest that IL1B polymorphisms may play a role in the susceptibility of unrelated Koreans to develop

STUDI SIMULASI MENGGUNAKAN FUZZY C-MEANS DALAM MENGKLASIFIKASI KONSTRUK TES

Directory of Open Access Journals (Sweden)

Rukli Rukli

2013-01-01

Full Text Available Tulisan ini memperkenalkan metode fuzzy c-means dalam mengklasifikasi konstruk tes. Untuk memverifikasi sifat unidimensional suatu tes biasanya menggunakan analisis faktor sebagai bagian dari statistik parametrik dengan beberapa persyaratan yang ketat sedangkan metode fuzzy c-means termasuk metode heuristik yang tidak memerlukan persyaratan yang ketat. Studi simulasi penelitian ini menggunakan dua metode yakni analisis faktor menggunakan program SPSS dan fuzzy c-means menggunakan program Matlab. Data simulasi menggunakan tipe data dikotomi dan politomi yang dibangkitkan lewat prog-ram Microsoft Office Excel dengan desain 2 kategori, yakni: tiga butir soal dengan banyak peserta tes 10, dan 30 butir soal dengan banyak peserta tes 100. Hasil simulasi menunjukkan bahwa metode fuzzy c-means lebih memberikan gambaran pengelompokan secara deskriptif dan dinamis pada semua desain yang telah dibuat dalam memverifikasi unidimensional pada suatu tes. Kata kunci: fuzzy c-means, analisis faktor, unidimensional _____________________________________________________________ SIMULATION STUDY USING FUZZY C-MEANS FOR CLASIFYING TEST CONSTRUCTION Abstract This paper introduces the fuzzy c-means method for classifying the test constructs. To verify the unidimensional a test typically uses factor analysis as part of parametric statistics with some strict requirements, while fuzzy c-means methods including method heuristic that do not require strict require-ments. Simulation comparison between the method of factor analysis using SPSS program and fuzzy c-means methods using Matlab. Simulation data using data type dichotomy and politomus generated through Microsoft Office Excel programs each with a number of 3 items using the number of participants 10 tests, while the number of 30 test items using the number as many as 100 participants. The simulation results show that the fuzzy c-means method provides a more descriptive and dyna-mic grouping of all the designs that

Construction and characterization of spherical Si solar cells combined with SiC electric power inverter

Science.gov (United States)

Oku, Takeo; Matsumoto, Taisuke; Hiramatsu, Kouichi; Yasuda, Masashi; Shimono, Akio; Takeda, Yoshikazu; Murozono, Mikio

2015-02-01

Spherical silicon (Si) photovoltaic solar cell systems combined with an electric power inverter using silicon carbide (SiC) field-effect transistor (FET) were constructed and characterized, which were compared with an ordinary Si-based converter. The SiC-FET devices were introduced in the direct current-alternating current (DC-AC) converter, which was connected with the solar panels. The spherical Si solar cells were used as the power sources, and the spherical Si panels are lighter and more flexible compared with the ordinary flat Si solar panels. Conversion efficiencies of the spherical Si solar cells were improved by using the SiC-FET.

Construction of a highly thermostable 1,3-1,4-β-glucanase by combinational mutagenesis and its potential application in the brewing industry.

Science.gov (United States)

Niu, Chengtuo; Zhu, Linjiang; Hill, Annie; Alex Speers, R; Li, Qi

2017-01-01

To improve the thermostability and catalytic property of a mesophilic 1,3-1,4-β-glucanase by combinational mutagenesis and to test its effect in congress mashing. A mutant β-glucanase (rE-BglTO) constructed by combinational mutagenesis showed a 25 °C increase in optimal temperature (to 70 °C) a 19.5 °C rise in T 50 value and a 15.6 °C increase in melting temperature compared to wild-type enzyme. Its half-life values at 60 and 70 °C were 152 and 99 min, which were 370 and 800 % higher than those of wild-type enzyme. Besides, its specific activity and k cat value were 42,734 U mg -1 and 189 s -1 while its stability under acidic conditions was also improved. In flask fermentation, the catalytic activity of rE-BglTO reached 2381 U ml -1 , which was 63 % higher than that of wild-type enzyme. The addition of rE-BglTO in congress mashing decreased the filtration time and viscosity by 21.3 and 9.6 %, respectively. The mutant β-glucanase showed high catalytic activity and thermostability which indicated that rE-BglTO is a good candidate for application in the brewing industry.

[Construction of Corynebacterium crenatum AS 1.542 δ argR and analysis of transcriptional levels of the related genes of arginine biosynthetic pathway].

Science.gov (United States)

Chen, Xuelan; Tang, Li; Jiao, Haitao; Xu, Feng; Xiong, Yonghua

2013-01-04

ArgR, coded by the argR gene from Corynebacterium crenatum AS 1.542, acts as a negative regulator in arginine biosynthetic pathway. However, the effect of argR on transcriptional levels of the related biosynthetic genes has not been reported. Here, we constructed a deletion mutant of argR gene: C. crenatum AS 1.542 Delta argR using marker-less knockout technology, and compared the changes of transcriptional levels of the arginine biosynthetic genes between the mutant strain and the wild-type strain. We used marker-less knockout technology to construct C. crenatum AS 1.542 Delta argR and analyzed the changes of the relate genes at the transcriptional level using real-time fluorescence quantitative PCR. C. crenatum AS 1.542 Delta argR was successfully obtained and the transcriptional level of arginine biosynthetic genes in this mutant increased significantly with an average of about 162.1 folds. The arginine biosynthetic genes in C. crenatum are clearly controlled by the negative regulator ArgR. However, the deletion of this regulator does not result in a clear change in arginine production in the bacteria.

Dicty_cDB: Contig-U14038-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available hophyton rubrum cDNA library 8 Tric... 54 0.006 1 ( DW708366 ) EST031847 Tric...hophyton rubrum cDNA library 8 Tric... 54 0.006 1 ( DW693636 ) EST017117 Trichophyton rubrum cDNA library 3 Tric...... 54 0.006 1 ( DW688891 ) EST012372 Trichophyton rubrum cDNA library 2 Tric... 54 0.006 1 ( DW688872 ) EST012353 Tric...hophyton rubrum cDNA library 2 Tric... 54 0.006 1 ( DW686711 ) EST010192 Tric...hophyton rubrum cDNA library 1 Tric... 54 0.006 1 ( DW685118 ) EST008599 Trichophyton rubrum cDNA library 1 Tric

χ_{c1} and χ_{c2} Resonance Parameters with the Decays χ_{c1,c2}→J/ψμ^{+}μ^{-}.

Science.gov (United States)

Aaij, R; Adeva, B; Adinolfi, M; Ajaltouni, Z; Akar, S; Albrecht, J; Alessio, F; Alexander, M; Alfonso Albero, A; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves, A A; Amato, S; Amerio, S; Amhis, Y; An, L; Anderlini, L; Andreassi, G; Andreotti, M; Andrews, J E; Appleby, R B; Archilli, F; d'Argent, P; Arnau Romeu, J; Artamonov, A; Artuso, M; Aslanides, E; Atzeni, M; Auriemma, G; Baalouch, M; Babuschkin, I; Bachmann, S; Back, J J; Badalov, A; Baesso, C; Baker, S; Balagura, V; Baldini, W; Baranov, A; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Baryshnikov, F; Batozskaya, V; Battista, V; Bay, A; Beaucourt, L; Beddow, J; Bedeschi, F; Bediaga, I; Beiter, A; Bel, L J; Beliy, N; Bellee, V; Belloli, N; Belous, K; Belyaev, I; Ben-Haim, E; Bencivenni, G; Benson, S; Beranek, S; Berezhnoy, A; Bernet, R; Berninghoff, D; Bertholet, E; Bertolin, A; Betancourt, C; Betti, F; Bettler, M-O; van Beuzekom, M; Bezshyiko, Ia; Bifani, S; Billoir, P; Birnkraut, A; Bizzeti, A; Bjørn, M; Blake, T; Blanc, F; Blusk, S; Bocci, V; Boettcher, T; Bondar, A; Bondar, N; Bordyuzhin, I; Borghi, S; Borisyak, M; Borsato, M; Bossu, F; Boubdir, M; Bowcock, T J V; Bowen, E; Bozzi, C; Braun, S; Britton, T; Brodzicka, J; Brundu, D; Buchanan, E; Burr, C; Bursche, A; Buytaert, J; Byczynski, W; Cadeddu, S; Cai, H; Calabrese, R; Calladine, R; Calvi, M; Calvo Gomez, M; Camboni, A; Campana, P; Campora Perez, D H; Capriotti, L; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carniti, P; Carson, L; Carvalho Akiba, K; Casse, G; Cassina, L; Cattaneo, M; Cavallero, G; Cenci, R; Chamont, D; Chapman, M G; Charles, M; Charpentier, Ph; Chatzikonstantinidis, G; Chefdeville, M; Chen, S; Cheung, S F; Chitic, S-G; Chobanova, V; Chrzaszcz, M; Chubykin, A; Ciambrone, P; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Cogan, J; Cogneras, E; Cogoni, V; Cojocariu, L; Collins, P; Colombo, T; Comerma-Montells, A; Contu, A; Cook, A; Coombs, G; Coquereau, S; Corti, G; Corvo, M; Costa Sobral, C M; Couturier, B; Cowan, G A; Craik, D C; Crocombe, A; Cruz Torres, M; Currie, R; D'Ambrosio, C; Da Cunha Marinho, F; Dall'Occo, E; Dalseno, J; Davis, A; De Aguiar Francisco, O; De Capua, S; De Cian, M; De Miranda, J M; De Paula, L; De Serio, M; De Simone, P; Dean, C T; Decamp, D; Del Buono, L; Dembinski, H-P; Demmer, M; Dendek, A; Derkach, D; Deschamps, O; Dettori, F; Dey, B; Di Canto, A; Di Nezza, P; Dijkstra, H; Dordei, F; Dorigo, M; Dosil Suárez, A; Douglas, L; Dovbnya, A; Dreimanis, K; Dufour, L; Dujany, G; Durante, P; Dzhelyadin, R; Dziewiecki, M; Dziurda, A; Dzyuba, A; Easo, S; Ebert, M; Egede, U; Egorychev, V; Eidelman, S; Eisenhardt, S; Eitschberger, U; Ekelhof, R; Eklund, L; Ely, S; Esen, S; Evans, H M; Evans, T; Falabella, A; Farley, N; Farry, S; Fazzini, D; Federici, L; Ferguson, D; Fernandez, G; Fernandez Declara, P; Fernandez Prieto, A; Ferrari, F; Ferreira Rodrigues, F; Ferro-Luzzi, M; Filippov, S; Fini, R A; Fiorini, M; Firlej, M; Fitzpatrick, C; Fiutowski, T; Fleuret, F; Fohl, K; Fontana, M; Fontanelli, F; Forshaw, D C; Forty, R; Franco Lima, V; Frank, M; Frei, C; Fu, J; Funk, W; Furfaro, E; Färber, C; Gabriel, E; Gallas Torreira, A; Galli, D; Gallorini, S; Gambetta, S; Gandelman, M; Gandini, P; Gao, Y; Garcia Martin, L M; García Pardiñas, J; Garra Tico, J; Garrido, L; Garsed, P J; Gascon, D; Gaspar, C; Gavardi, L; Gazzoni, G; Gerick, D; Gersabeck, E; Gersabeck, M; Gershon, T; Ghez, Ph; Gianì, S; Gibson, V; Girard, O G; Giubega, L; Gizdov, K; Gligorov, V V; Golubkov, D; Golutvin, A; Gomes, A; Gorelov, I V; Gotti, C; Govorkova, E; Grabowski, J P; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graverini, E; Graziani, G; Grecu, A; Greim, R; Griffith, P; Grillo, L; Gruber, L; Gruberg Cazon, B R; Grünberg, O; Gushchin, E; Guz, Yu; Gys, T; Göbel, C; Hadavizadeh, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hamilton, B; Han, X; Hancock, T H; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Hasse, C; Hatch, M; He, J; Hecker, M; Heinicke, K; Heister, A; Hennessy, K; Henrard, P; Henry, L; van Herwijnen, E; Heß, M; Hicheur, A; Hill, D; Hombach, C; Hopchev, P H; Hu, W; Huard, Z C; Hulsbergen, W; Humair, T; Hushchyn, M; Hutchcroft, D; Ibis, P; Idzik, M; Ilten, P; Jacobsson, R; Jalocha, J; Jans, E; Jawahery, A; Jiang, F; John, M; Johnson, D; Jones, C R; Joram, C; Jost, B; Jurik, N; Kandybei, S; Karacson, M; Kariuki, J M; Karodia, S; Kazeev, N; Kecke, M; Keizer, F; Kelsey, M; Kenzie, M; Ketel, T; Khairullin, E; Khanji, B; Khurewathanakul, C; Kirn, T; Klaver, S; Klimaszewski, K; Klimkovich, T; Koliiev, S; Kolpin, M; Kopecna, R; Koppenburg, P; Kosmyntseva, A; Kotriakhova, S; Kozeiha, M; Kravchuk, L; Kreps, M; Kress, F; Krokovny, P; Kruse, F; Krzemien, W; Kucewicz, W; Kucharczyk, M; Kudryavtsev, V; Kuonen, A K; Kvaratskheliya, T; Lacarrere, D; Lafferty, G; Lai, A; Lanfranchi, G; Langenbruch, C; Latham, T; Lazzeroni, C; Le Gac, R; Leflat, A; Lefrançois, J; Lefèvre, R; Lemaitre, F; Lemos Cid, E; Leroy, O; Lesiak, T; Leverington, B; Li, P-R; Li, T; Li, Y; Li, Z; Likhomanenko, T; Lindner, R; Lionetto, F; Lisovskyi, V; Liu, X; Loh, D; Loi, A; Longstaff, I; Lopes, J H; Lucchesi, D; Luchinsky, A; Lucio Martinez, M; Luo, H; Lupato, A; Luppi, E; Lupton, O; Lusiani, A; Lyu, X; Machefert, F; Maciuc, F; Macko, V; Mackowiak, P; Maddrell-Mander, S; Maev, O; Maguire, K; Maisuzenko, D; Majewski, M W; Malde, S; Malecki, B; Malinin, A; Maltsev, T; Manca, G; Mancinelli, G; Marangotto, D; Maratas, J; Marchand, J F; Marconi, U; Marin Benito, C; Marinangeli, M; Marino, P; Marks, J; Martellotti, G; Martin, M; Martinelli, M; Martinez Santos, D; Martinez Vidal, F; Massacrier, L M; Massafferri, A; Matev, R; Mathad, A; Mathe, Z; Matteuzzi, C; Mauri, A; Maurice, E; Maurin, B; Mazurov, A; McCann, M; McNab, A; McNulty, R; Mead, J V; Meadows, B; Meaux, C; Meier, F; Meinert, N; Melnychuk, D; Merk, M; Merli, A; Michielin, E; Milanes, D A; Millard, E; Minard, M-N; Minzoni, L; Mitzel, D S; Mogini, A; Molina Rodriguez, J; Mombächer, T; Monroy, I A; Monteil, S; Morandin, M; Morello, M J; Morgunova, O; Moron, J; Morris, A B; Mountain, R; Muheim, F; Mulder, M; Müller, D; Müller, J; Müller, K; Müller, V; Naik, P; Nakada, T; Nandakumar, R; Nandi, A; Nasteva, I; Needham, M; Neri, N; Neubert, S; Neufeld, N; Neuner, M; Nguyen, T D; Nguyen-Mau, C; Nieswand, S; Niet, R; Nikitin, N; Nikodem, T; Nogay, A; O'Hanlon, D P; Oblakowska-Mucha, A; Obraztsov, V; Ogilvy, S; Oldeman, R; Onderwater, C J G; Ossowska, A; Otalora Goicochea, J M; Owen, P; Oyanguren, A; Pais, P R; Palano, A; Palutan, M; Papanestis, A; Pappagallo, M; Pappalardo, L L; Parker, W; Parkes, C; Passaleva, G; Pastore, A; Patel, M; Patrignani, C; Pearce, A; Pellegrino, A; Penso, G; Pepe Altarelli, M; Perazzini, S; Perret, P; Pescatore, L; Petridis, K; Petrolini, A; Petrov, A; Petruzzo, M; Picatoste Olloqui, E; Pietrzyk, B; Pikies, M; Pinci, D; Pisani, F; Pistone, A; Piucci, A; Placinta, V; Playfer, S; Plo Casasus, M; Polci, F; Poli Lener, M; Poluektov, A; Polyakov, I; Polycarpo, E; Pomery, G J; Ponce, S; Popov, A; Popov, D; Poslavskii, S; Potterat, C; Price, E; Prisciandaro, J; Prouve, C; Pugatch, V; Puig Navarro, A; Pullen, H; Punzi, G; Qian, W; Quagliani, R; Quintana, B; Rachwal, B; Rademacker, J H; Rama, M; Ramos Pernas, M; Rangel, M S; Raniuk, I; Ratnikov, F; Raven, G; Ravonel Salzgeber, M; Reboud, M; Redi, F; Reichert, S; Dos Reis, A C; Remon Alepuz, C; Renaudin, V; Ricciardi, S; Richards, S; Rihl, M; Rinnert, K; Rives Molina, V; Robbe, P; Robert, A; Rodrigues, A B; Rodrigues, E; Rodriguez Lopez, J A; Rogozhnikov, A; Roiser, S; Rollings, A; Romanovskiy, V; Romero Vidal, A; Ronayne, J W; Rotondo, M; Rudolph, M S; Ruf, T; Ruiz Valls, P; Ruiz Vidal, J; Saborido Silva, J J; Sadykhov, E; Sagidova, N; Saitta, B; Salustino Guimaraes, V; Sanchez Mayordomo, C; Sanmartin Sedes, B; Santacesaria, R; Santamarina Rios, C; Santimaria, M; Santovetti, E; Sarpis, G; Sarti, A; Satriano, C; Satta, A; Saunders, D M; Savrina, D; Schael, S; Schellenberg, M; Schiller, M; Schindler, H; Schmelling, M; Schmelzer, T; Schmidt, B; Schneider, O; Schopper, A; Schreiner, H F; Schubiger, M; Schune, M-H; Schwemmer, R; Sciascia, B; Sciubba, A; Semennikov, A; Sepulveda, E S; Sergi, A; Serra, N; Serrano, J; Sestini, L; Seyfert, P; Shapkin, M; Shapoval, I; Shcheglov, Y; Shears, T; Shekhtman, L; Shevchenko, V; Siddi, B G; Silva Coutinho, R; Silva de Oliveira, L; Simi, G; Simone, S; Sirendi, M; Skidmore, N; Skwarnicki, T; Smith, E; Smith, I T; Smith, J; Smith, M; Soares Lavra, L; Sokoloff, M D; Soler, F J P; Souza De Paula, B; Spaan, B; Spradlin, P; Sridharan, S; Stagni, F; Stahl, M; Stahl, S; Stefko, P; Stefkova, S; Steinkamp, O; Stemmle, S; Stenyakin, O; Stepanova, M; Stevens, H; Stone, S; Storaci, B; Stracka, S; Stramaglia, M E; Straticiuc, M; Straumann, U; Sun, J; Sun, L; Sutcliffe, W; Swientek, K; Syropoulos, V; Szumlak, T; Szymanski, M; T'Jampens, S; Tayduganov, A; Tekampe, T; Tellarini, G; Teubert, F; Thomas, E; van Tilburg, J; Tilley, M J; Tisserand, V; Tobin, M; Tolk, S; Tomassetti, L; Tonelli, D; Toriello, F; Tourinho Jadallah Aoude, R; Tournefier, E; Traill, M; Tran, M T; Tresch, M; Trisovic, A; Tsaregorodtsev, A; Tsopelas, P; Tully, A; Tuning, N; Ukleja, A; Usachov, A; Ustyuzhanin, A; Uwer, U; Vacca, C; Vagner, A; Vagnoni, V; Valassi, A; Valat, S; Valenti, G; Vazquez Gomez, R; Vazquez Regueiro, P; Vecchi, S; van Veghel, M; Velthuis, J J; Veltri, M; Veneziano, G; Venkateswaran, A; Verlage, T A; Vernet, M; Vesterinen, M; Viana Barbosa, J V; Viaud, B; Vieira, D; Vieites Diaz, M; Viemann, H; Vilasis-Cardona, X; Vitti, M; Volkov, V; Vollhardt, A; Voneki, B; Vorobyev, A; Vorobyev, V; Voß, C; de Vries, J A; Vázquez Sierra, C; Waldi, R; Wallace, C; Wallace, R; Walsh, J; Wang, J; Ward, D R; Wark, H M; Watson, N K; Websdale, D; Weiden, A; Weisser, C; Whitehead, M; Wicht, J; Wilkinson, G; Wilkinson, M; Williams, M; Williams, M P; Williams, M; Williams, T; Wilson, F F; Wimberley, J; Winn, M; Wishahi, J; Wislicki, W; Witek, M; Wormser, G; Wotton, S A; Wraight, K; Wyllie, K; Xie, Y; Xu, M; Xu, Z; Yang, Z; Yang, Z; Yao, Y; Yin, H; Yu, J; Yuan, X; Yushchenko, O; Zarebski, K A; Zavertyaev, M; Zhang, L; Zhang, Y; Zhelezov, A; Zheng, Y; Zhu, X; Zhukov, V; Zonneveld, J B; Zucchelli, S

2017-12-01

The decays χ_{c1}→J/ψμ^{+}μ^{-} and χ_{c2}→J/ψμ^{+}μ^{-} are observed and used to study the resonance parameters of the χ_{c1} and χ_{c2} mesons. The masses of these states are measured to be m(χ_{c1})=3510.71±0.04(stat)±0.09(syst)  MeV and m(χ_{c2})=3556.10±0.06(stat)±0.11(syst)  MeV, where the knowledge of the momentum scale for charged particles dominates the systematic uncertainty. The momentum-scale uncertainties largely cancel in the mass difference m(χ_{c2})-m(χ_{c1})=45.39±0.07(stat)±0.03(syst)  MeV. The natural width of the χ_{c2} meson is measured to be Γ(χ_{c2})=2.10±0.20(stat)±0.02(syst)  MeV. These results are in good agreement with and have comparable precision to the current world averages.

Comparison of systems for memory allocation in the C programming language

OpenAIRE

Zavrtanik, Matej

2016-01-01

The bachelor thesis describes memory allocation. Work begins with description of mechanism, system calls and data structures used in memory allocators. Goals of memory allocation ares listed along with problems which must be avoided. Afterwards construction and allocating of popular memory allocators is described. Work ends with comparison of memory allocators based on time of execution of programs and memory usage, on which conclusion is based.

The Construction of a Vague Fuzzy Measure Through L1 Parameter Optimization

Science.gov (United States)

2012-08-26

Programming v. 1.21, http://cvxr.com/cvx, (2011) 11 [3] E.J. Candes, J. Romberg and T. Tao. Robust Uncertainty Principles: Exact Signal Reconstruction From...Annales de I’institut Fourer, 5 (1954), pp. 131-295 [9] D. Diakoulaki, C. Antunes and A. Martins. MCDA in Energy Planning, Int. Series in Operations...formance and Tests , Fuzzy Sets and Systems, Vol. 65, Issues 2-3 (1994), pp.255-271 [15] M. Grabisch. Fuzzy Integral in Multicriteria Decision Making, Fuzzy

26 CFR 1.381(c)(5)-1 - Inventories.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 4 2010-04-01 2010-04-01 false Inventories. 1.381(c)(5)-1 Section 1.381(c)(5)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Insolvency Reorganizations § 1.381(c)(5)-1 Inventories. (a) Carryover requirement—(1...

Constructing passive houses

Energy Technology Data Exchange (ETDEWEB)

Oehler, S. [Oehler Faigle Archkom Solar Architektur, Bretten (Germany)

2005-07-01

Everybody can learn to build energy-efficient. It needs theoretical and practical experience. 1997 we built the first freestanding Passive House in Europe, the Passive House Oehler. There had been a lot of questions, starting with the insecurity, whether the calculation program of the Passive House Institute, the PHPP, is working properly in our case. Nobody knew at that time because nobody tried it out before. It took us a lot of time to find out and every detail of the construction hat to be invented to meet the very high demand of thermal quality. All the following houses needed less time and had fewer open questions, adding one piece of experience with every building. 2002 we realised the biggest Passive House, the office building Energon Ulm with 420 working spaces. In the meantime we have learned a lot like how to produce prefabricated timber elements for the facades, providing good insulation, air tightness and avoiding serious thermal bridges. We have proofed, that any kind of building type can be a Passive House. And with increasing experience the freedom of design and construction is growing. Even the economical efficiency increased. The Energon Ulm is providing a much better indoor climate than any other office building and was build 10 % cheaper than an average German office building. At present the Passive House Standard is the most efficient solution for the user to live in the desired comfort zone between 20 C and 25 C. This zone of individual feeling-well can be described with the term ''operative temperature''. This term is defined by factors like air temperature, radiation temperature of warm and cold surfaces, air speed and humidity. The result of all these factors has to be within 18 C to 25 C without accepting one of the factors getting extreme.

Programming Language Software For Graphics Applications

Science.gov (United States)

Beckman, Brian C.

1993-01-01

New approach reduces repetitive development of features common to different applications. High-level programming language and interactive environment with access to graphical hardware and software created by adding graphical commands and other constructs to standardized, general-purpose programming language, "Scheme". Designed for use in developing other software incorporating interactive computer-graphics capabilities into application programs. Provides alternative to programming entire applications in C or FORTRAN, specifically ameliorating design and implementation of complex control and data structures typifying applications with interactive graphics. Enables experimental programming and rapid development of prototype software, and yields high-level programs serving as executable versions of software-design documentation.

Professional Parallel Programming with C# Master Parallel Extensions with NET 4

CERN Document Server

Hillar, Gastón

2010-01-01

Expert guidance for those programming today's dual-core processors PCs As PC processors explode from one or two to now eight processors, there is an urgent need for programmers to master concurrent programming. This book dives deep into the latest technologies available to programmers for creating professional parallel applications using C#, .NET 4, and Visual Studio 2010. The book covers task-based programming, coordination data structures, PLINQ, thread pools, asynchronous programming model, and more. It also teaches other parallel programming techniques, such as SIMD and vectorization.Teach

Construction and characterization of a full-length cDNA library for the wheat stripe rust pathogen (Puccinia striiformis f. sp. tritici

Directory of Open Access Journals (Sweden)

Chen Xianming

2007-06-01

Full Text Available Abstract Background Puccinia striiformis is a plant pathogenic fungus causing stripe rust, one of the most important diseases on cereal crops and grasses worldwide. However, little is know about its genome and genes involved in the biology and pathogenicity of the pathogen. We initiated the functional genomic research of the fungus by constructing a full-length cDNA and determined functions of the first group of genes by sequence comparison of cDNA clones to genes reported in other fungi. Results A full-length cDNA library, consisting of 42,240 clones with an average cDNA insert of 1.9 kb, was constructed using urediniospores of race PST-78 of P. striiformis f. sp. tritici. From 196 sequenced cDNA clones, we determined functions of 73 clones (37.2%. In addition, 36 clones (18.4% had significant homology to hypothetical proteins, 37 clones (18.9% had some homology to genes in other fungi, and the remaining 50 clones (25.5% did not produce any hits. From the 73 clones with functions, we identified 51 different genes encoding protein products that are involved in amino acid metabolism, cell defense, cell cycle, cell signaling, cell structure and growth, energy cycle, lipid and nucleotide metabolism, protein modification, ribosomal protein complex, sugar metabolism, transcription factor, transport metabolism, and virulence/infection. Conclusion The full-length cDNA library is useful in identifying functional genes of P. striiformis.

Quick Way to Port Existing C/C++ Chemoinformatics Toolkits to the Web Using Emscripten.

Science.gov (United States)

Jiang, Chen; Jin, Xi

2017-10-23

Emscripten is a special open source compiler that compiles C and C++ code into JavaScript. By utilizing this compiler, some typical C/C++ chemoinformatics toolkits and libraries are quickly ported to to web. The compiled JavaScript files have sizes similar to native programs, and from a series of constructed benchmarks, the performance of the compiled JavaScript codes is also close to that of the native codes and is better than the handwritten JavaScript codes. Therefore, we believe that Emscripten is a feasible and practical tool for reusing existing C/C++ codes on the web, and many other chemoinformatics or molecular calculation software tools can also be easily ported by Emscripten.

Sexual Harassment DEOCS 4.1 Construct Validity Summary

Science.gov (United States)

2017-08-01

Sexual Harassment DEOCS 4.1 Construct Validity Summary DEFENSE EQUAL OPPORTUNITY MANAGEMENT INSTITUTE...DIRECTORATE OF RESEARCH DEVELOPMENT AND STRATEGIC INITIATIVES Directed by Dr. Daniel P. McDonald, Executive Director 366 Tuskegee Airmen Drive Patrick AFB

Interaction of C1q and mannan-binding lectin (MBL) with C1r, C1s, MBL-associated serine proteases 1 and 2, and the MBL-associated protein MAp19

DEFF Research Database (Denmark)

Thiel, S; Petersen, Steen Vang; Vorup-Jensen, T

2000-01-01

. There is controversy as to whether MBL can utilize C1r and C1s or, inversely, whether C1q can utilize MASP-1 and 2. Serum deficient in C1r produced no complement activation in IgG-coated microwells, whereas activation was seen in mannan-coated microwells. In serum, C1r and C1s were found to be associated only with C1q...

IRT-based test construction

OpenAIRE

van der Linden, Willem J.; Theunissen, T.J.J.M.; Boekkooi-Timminga, Ellen; Kelderman, Henk

1987-01-01

Four discussions of test construction based on item response theory (IRT) are presented. The first discussion, "Test Design as Model Building in Mathematical Programming" (T.J.J.M. Theunissen), presents test design as a decision process under certainty. A natural way of modeling this process leads to mathematical programming. General models of test construction are discussed, with information about algorithms and heuristics; ideas about the analysis and refinement of test constraints are also...

Constructing effective photocatalytic purification system with P-introduced g-C3N4 for elimination of UO22+

Science.gov (United States)

Wu, Xi; Jiang, Shujuan; Song, Shaoqing; Sun, Chuanzhi

2018-02-01

Due to the inherent defects of precursor molecular structure, the limited effect of structure in the formed g-C3N4 will weaken the extension of delocalization of π electrons between the adjacent tri-s-triazine or heptazine units of g-C3N4, which thus leads to poor visible-light absorption, low utilization efficiency of charge carrier. Herein, P-introduced g-C3N4 (PC3N4) photocatalysts were constructed by partially replacing C with tributyl phosphate as precursor, and the as-designed PC3N4 photocatalysts were used to eliminate aqueous uranyl ion by photocatalytic reduction technology under visible-light irradiation. Experimental and DFT revealed that introduction of P into g-C3N4 significantly modified its electronic structure, as reflected by the narrowed band gap, enhanced visible-light absorption as well as improved transfer capability of photogenerated charge. Therefore, photocatalytic activity of PC3N4 was much better than that of pristine g-C3N4 and conventional reducing-type photocatalysts. This study suggests an efficient strategy for construct effective visible-light-responsive photocatalysts for radioactive environmental remediation.

Dicty_cDB: Contig-U04547-1 [Dicty_cDB