WorldWideScience

Sample records for constitution diagnosis method

  1. Development of an integrated Sasang constitution diagnosis method using face, body shape, voice, and questionnaire information.

    Science.gov (United States)

    Do, Jun-Hyeong; Jang, Eunsu; Ku, Boncho; Jang, Jun-Su; Kim, Honggie; Kim, Jong Yeol

    2012-07-04

    Sasang constitutional medicine (SCM) is a unique form of traditional Korean medicine that divides human beings into four constitutional types (Tae-Yang: TY, Tae-Eum: TE, So-Yang: SY, and So-Eum: SE), which differ in inherited characteristics, such as external appearance, personality traits, susceptibility to particular diseases, drug responses, and equilibrium among internal organ functions. According to SCM, herbs that belong to a certain constitution cannot be used in patients with other constitutions; otherwise, this practice may result in no effect or in an adverse effect. Thus, the diagnosis of SC type is the most crucial step in SCM practice. The diagnosis, however, tends to be subjective due to a lack of quantitative standards for SC diagnosis. We have attempted to make the diagnosis method as objective as possible by basing it on an analysis of quantitative data from various Oriental medical clinics. Four individual diagnostic models were developed with multinomial logistic regression based on face, body shape, voice, and questionnaire responses. Inspired by SCM practitioners' holistic diagnostic processes, an integrated diagnostic model was then proposed by combining the four individual models. The diagnostic accuracies in the test set, after the four individual models had been integrated into a single model, improved to 64.0% and 55.2% in the male and female patient groups, respectively. Using a cut-off value for the integrated SC score, such as 1.6, the accuracies increased by 14.7% in male patients and by 4.6% in female patients, which showed that a higher integrated SC score corresponded to a higher diagnostic accuracy. This study represents the first trial of integrating the objectification of SC diagnosis based on quantitative data and SCM practitioners' holistic diagnostic processes. Although the diagnostic accuracy was not great, it is noted that the proposed diagnostic model represents common rules among practitioners who have various points of

  2. Quantitative Sasang Constitution Diagnosis Method for Distinguishing between Tae-eumin and Soeumin Types Based on Elasticity Measurements of the Skin of the Human Hand

    OpenAIRE

    Song, Han Wook; Lee, SungJun; Park, Yon Kyu; Woo, Sam Yong

    2009-01-01

    The usefulness of constitutional diagnoses based on skin measurements has been established in oriental medicine. However, it is very difficult to standardize traditional diagnosis methods. According to Sasang constitutional medicine, humans can be distinguished based on properties of the skin, including its texture, roughness, hardness and elasticity. The elasticity of the skin was previously used to distinguish between people with Tae-eumin (TE) and Soeumin (SE) constitutions. The present st...

  3. Quantitative Sasang Constitution Diagnosis Method for Distinguishing between Tae-eumin and Soeumin Types Based on Elasticity Measurements of the Skin of the Human Hand.

    Science.gov (United States)

    Song, Han Wook; Lee, Sungjun; Park, Yon Kyu; Woo, Sam Yong

    2009-09-01

    The usefulness of constitutional diagnoses based on skin measurements has been established in oriental medicine. However, it is very difficult to standardize traditional diagnosis methods. According to Sasang constitutional medicine, humans can be distinguished based on properties of the skin, including its texture, roughness, hardness and elasticity. The elasticity of the skin was previously used to distinguish between people with Tae-eumin (TE) and Soeumin (SE) constitutions. The present study designed a system that uses a compression method to measure the elasticity of hand skin and evaluated its measurement repeatability. The proposed system was used to compare the skin elasticity between SE and TE subjects, which produced a measurement repeatability error of <3%. The proposed system is suitable for use as a quantitative constitution diagnosis method for distinguishing between TE and SE subjects with an acceptable level of uncertainty.

  4. Repeatability of Pulse Diagnosis and Body Constitution Diagnosis in Traditional Indian Ayurveda Medicine

    Science.gov (United States)

    Waagepetersen, Rasmus; Toft, Egon; Prasad, Ramjee; Raturi, Lokesh

    2012-01-01

    In Ayurveda, pulse diagnosis and body constitution diagnosis have a long historical use; still, there is lack of quantitative measure of the reliability of these diagnostic methods. Reliability means consistency of information. Consistent diagnosis leads to consistent treatment and is important for clinical practice, education, and research. The objective of this study is to study the methodology to evaluate the test-retest reliability (repeatability) of pulse diagnosis and body constitution diagnosis. A double-blinded, controlled, clinical trial was conducted in Copenhagen. The same doctor, an expert in Ayurvedic pulse diagnosis, examined the pulse and body constitution of 17 healthy participants twice, in random order without seeing them. A metric on pulse and body constitution variables was developed. Cohen's weighted kappa statistic was used as a measure of intra-rater reliability. Permutation tests were used to test the hypothesis of homogeneous diagnosis (ie, the doctor's diagnosis does not depend on the subject). The hypothesis of homogeneous classification was rejected on the 5% significance level (P values of .02 and .001, respectively, for pulse and body constitution diagnosis). According to the Landis and Koch scale, values of the weighted kappa for pulse diagnosis (P = .42) and body constitution diagnosis (P = .65) correspond to “moderate” and “substantial” agreement, respectively. There was a reasonable level of consistency between 2 pulse and body constitution diagnoses. Further studies are required to quantify inter-subject and intra-subject agreement for greater understanding of reliability of pulse and body constitution diagnosis. PMID:27257530

  5. Repeatability of pulse diagnosis and body constitution diagnosis in traditional Indian Ayurveda medicine

    DEFF Research Database (Denmark)

    Kurande, Vrinda; Waagepetersen, Rasmus; Toft, Egon

    2012-01-01

    In Ayurveda, pulse and body constitution diagnosis have a long historical use; still there is lack of quantitative measure on e.g. reliability of this diagnostic method. Reliability means consistency of information. Consistent diagnosis leads to consistent treatment and is important for clinical ...

  6. Loading method of core constituting elements

    International Nuclear Information System (INIS)

    Kasai, Shigeo

    1976-01-01

    Purpose: To provide a remote-controlled replacing method for core constituting elements in a liquid-metal cooling fast breeder, wherein particularly, the core constituting elements are prevented from being loaded on the core position other than as designated. Constitution: The method comprises a first step which determines a position of a suitable neutron shielding body in order to measure a reference level of complete insertion of the core constituting elements, a second step which inserts a gripper for a fuel exchanger, a third step which decides stroke dimensions of the complete insertion, and a fourth step which discriminates the core constituting elements to begin handling of fuel rods. The method further comprises a fifth step which determines a loading position of fuel rod, and a sixth step which inserts and loads fuel rods into the core. The method still further comprises a seventh step which compares and judges the dimension of loading stroke and the dimension of complete inserting stroke so that when coincided, loading is completed, and when not coincided, loading is not completed and then the cycle of the fourth step is repeated. (Kawakami, Y.)

  7. Current Researches on the Methods of Diagnosing Sasang Constitution: An Overview

    Directory of Open Access Journals (Sweden)

    Si-Woo Lee

    2009-01-01

    Full Text Available Sasang constitution diagnosis has traditionally been conducted by a Sasang constitutional medicine (SCM doctor who examines the external appearance, temperament and various symptoms of an individual and then collectively analyzes this information to determine their own constitutions. However, because this process is subjective and not quantitative, many researchers have been attempting to develop objective and reasonable methods of determining constitutions. In Korea, even though a wide range of research regarding SCM has been conducted, most of the work has not been revealed internationally. So in this review, the authors have searched the Journal of Sasang Constitutional Medicine, as well as other Korean domestic journal databases and Pubmed for research regarding modernized constitution diagnosis methods so to provide the understanding of current research state and outlook for future research.

  8. Diagnosis of Constitutional Hyperbilirubinemias by Sequential Scanning with 131I-BSP

    International Nuclear Information System (INIS)

    Ueda, Hideo; Lio, Masahiro; Yamada, Hideo; Kamada, Haruo; Luchi, Masahiko; Ishiwa, Mamoru

    1971-01-01

    Sequential liver scanning was introduced for the diagnosis of medical and surgical jaundices by Yamada and Taplin (1) using 131 I-Rose Bengal. Following this trial authors have reevaluated the 131 I-BSP (monoiodide) (2) and applied this dye successfully for the same purpose as well as for hepatic function study (2). In this paper, taking note of the fact that 131 I-BSP sequential scanning method makes visible the mechanism of liver uptake, intrahepatic transport and biliary excretion of this dye, the authors aimed to make clear the classification of constitutional hyperbilirubinemias and the pathophysiology of this disease subjects, which are still controversial among researchers.

  9. Determination of brazed joint constitutive law by inverse method

    International Nuclear Information System (INIS)

    Lovato, G.; Moret, F.; Gallo, P. le; Cailletaud, G.; Pilvin, P.

    1993-01-01

    An important parameter often neglected for the calculation of residual stresses in brazed ceramic/metal assemblies is the joint constitutive law. In situ camber measurements on a model system (axisymmetric TZM/InCuSil ABA/316L samples) performed using a special vertical dilatometer during the whole brazing thermal cycle are compared with results of FEM calculations based on published filler metal constitutive laws. A strong disagreement is observed. Actual constitutive law of the joint is determined from these measurements using a numerical inverse method. Calculated displacements are fully consistent with experimental ones. True solidification temperature of the joint is determined. The identified constitutive law of the joint exhibits a low flow stress from solidification temperature to 320 C. (orig.)

  10. [Modified Delphi method in the constitution of school sanitation standard].

    Science.gov (United States)

    Yin, Xunqiang; Liang, Ying; Tan, Hongzhuan; Gong, Wenjie; Deng, Jing; Luo, Jiayou; Di, Xiaokang; Wu, Yue

    2012-11-01

    To constitute school sanitation standard using modified Delphi method, and to explore the feasibility and the predominance of Delphi method in the constitution of school sanitation standard. Two rounds of expert consultations were adopted in this study. The data were analyzed with SPSS15.0 to screen indices of school sanitation standard. Thirty-two experts accomplished the 2 rounds of consultations. The average length of expert service was (24.69 ±8.53) years. The authority coefficient was 0.729 ±0.172. The expert positive coefficient was 94.12% (32/34) in the first round and 100% (32/32) in the second round. The harmonious coefficients of importance, feasibility and rationality in the second round were 0.493 (PDelphi method is a rapid, effective and feasible method in this field.

  11. Diagnosis and constitutional and laboratory features of Korean girls referred for precocious puberty

    Directory of Open Access Journals (Sweden)

    Doosoo Kim

    2012-12-01

    Full Text Available &lt;B&gt;Purpose:&lt;/B&gt; Precocious puberty is defined as breast development before the age of 8 years in girls. The present study aimed to reveal the diagnosis of Korean girls referred for precocious puberty and to compare the constitutional and endocrinological features among diagnosis groups. &lt;B&gt;Methods:&lt;/B&gt; The present study used a retrospective chart review of 988 Korean girls who had visited a pediatric endocrinology clinic from 2006 to 2010 for the evaluation of precocious puberty. Study groups comprised fast puberty, true precocious puberty (PP, pseudo PP, premature thelarche, and control. We determined the height standard deviation score (HSDS, weight standard deviation score (WSDS, and body mass index standard deviation score (BMISDS of each group using the published 2007 Korean growth charts. Hormone tests were performed at our outpatient clinic. &lt;B&gt;Results:&lt;/B&gt; The PP groups comprised fast puberty (67%, premature thelarche (17%, true PP (15%, and pseudo PP (1%. Advanced bone age and levels of estradiol, basal luteinizing hormone (LH, and peak LH after gonadotropin-releasing hormone stimulation testing were significantly high in the fast puberty and true PP groups compared with the control group. HSDS, WSDS, and BMISDS were significantly higher in the true PP group than in the control group (P&lt;0.05. &lt;B&gt;Conclusion:&lt;/B&gt; The frequent causes of PP were found to be fast puberty, true PP, and premature thelarche. Furthermore, BMISDS were significantly elevated in the true PP group. Therefore, we emphasize the need for regular follow-up of girls who are heavier or taller than others in the same age group.

  12. Diagnosis of Constitutional Mismatch Repair-Deficiency Syndrome Based on Microsatellite Instability and Lymphocyte Tolerance to Methylating Agents

    DEFF Research Database (Denmark)

    Bodo, Sahra; Colas, Chrystelle; Buhard, Olivier

    2015-01-01

    BACKGROUND & AIMS: Patients with bi-allelic germline mutations in mismatch repair (MMR) genes (MLH1, MSH2, MSH6, or PMS2) develop a rare but severe variant of Lynch syndrome called constitutional MMR deficiency (CMMRD). This syndrome is characterized by early-onset colorectal cancers, lymphomas...... or leukemias, and brain tumors. There is no satisfactory method for diagnosis of CMMRD because screens for mutations in MMR genes are noninformative for 30% of patients. MMR-deficient cancer cells are resistant to genotoxic agents and have microsatellite instability (MSI), due to accumulation of errors...

  13. Simple detection of germline microsatellite instability for diagnosis of constitutional mismatch repair cancer syndrome.

    Science.gov (United States)

    Ingham, Danielle; Diggle, Christine P; Berry, Ian; Bristow, Claire A; Hayward, Bruce E; Rahman, Nazneen; Markham, Alexander F; Sheridan, Eamonn G; Bonthron, David T; Carr, Ian M

    2013-06-01

    Heterozygous mutations in DNA mismatch repair (MMR) genes result in predisposition to colorectal cancer (hereditary nonpolyposis colorectal cancer or Lynch syndrome). Patients with biallelic mutations in these genes, however, present earlier, with constitutional mismatch repair deficiency cancer syndrome (CMMRD), which is characterized by a spectrum of rare childhood malignancies and café-au-lait skin patches. The hallmark of MMR deficiency, microsatellite instability (MSI), is readily detectable in tumor DNA in Lynch syndrome, but is also present in constitutional DNA of CMMRD patients. However, detection of constitutional or germline MSI (gMSI) has hitherto relied on technically difficult assays that are not routinely applicable for clinical diagnosis. Consequently, we have developed a simple high-throughput screening methodology to detect gMSI in CMMRD patients based on the presence of stutter peaks flanking a dinucleotide repeat allele when amplified from patient blood DNA samples. Using the three different microsatellite markers, the gMSI ratio was determined in a cohort of normal individuals and 10 CMMRD patients, with biallelic germline mutations in PMS2 (seven patients), MSH2 (one patient), or MSH6 (two patients). Subjects with either PMS2 or MSH2 mutations were easily identified; however, this measure was not altered in patients with CMMRD due to MSH6 mutation. © 2013 Wiley Periodicals, Inc.

  14. A Bibliographical Research of the Correlation Among Sasang Constitutional Disease and the Pulse Diagnosis

    Directory of Open Access Journals (Sweden)

    Kim Dong-jun

    2003-06-01

    Full Text Available The purpose of this research was to investigate the correlation Among Sasang Constitutional Disease and Examination of the pulse. I have gone over literatures of mainly 「Dongyi Soose Bowon」and the others Oriental Medical book was studied about the Pulse Diagnosis. And then I came to get some conclusion as follows. 1. Soeumin(소음인 the initial-stage symptoms of wulkwang disease(울광증; when the Superficial Pulse and the Superficial+Moderate Pulse is made a diagnosis, Ceongunggyegitang(천궁계지탕 and Gunggyuhyangsosan(궁귀향소산 can be used. 2. Soeumin(소음인 the initial-stage blood disease symptoms of wulkwang disease(울광증; when the Minute+deep Pulse is made a diagnosis, Palmulgunjatang(팔물군자탕 and Guakhyanggeonggisan(곽향정기산 can be used. 3. Soeumin(소음인 the initial-stage symptoms of mangyang disease(망양증; when the Yang region Superficial Pulse and the Yin region Weak Pulse is made a diagnosis, Hwanggigyegitang(황기계지탕, Bojungikgitang(보중익기탕 and Sengyangikgitang(승양익기탕 can be used. 4. Soeumin(소음인 the symptoms of taeum disease(태음증; when the Minute Pulse and Deep+Thin Pulse is made a diagnosis, Sasang Prescription can be used. 5. Soeumin(소음인 the symptoms of soeum disease(소음증; when the Minute+Thin Pulse, Deep Pulse and Thin+Deep+Rapid Pulse is made a diagnosis, Sasang Prescription can be used. 6. Soyangin(소양인 Wind of soyang disease(소양상풍증; when the Superficial+Tight Pulse is made a diagnosis, Hungbangpaedogsan(형방패독산 can be used. And when the Deep+Full with strong power Pulse is made a diagnosis, Hyungbangdojeoksan(형방도적산 can be used. 7. Soyangin(소양인 the symptoms of mangyeum disease(망음증; when the Superficial+Large+Rapid Pulse and Flood+Large Pulse is made a diagnosis, Hungbangsabaeksan(형방사백산 can be used. And when the Wiry+Thin Pulse is made a diagnosis, Hungbanggiwhangtang(형방지황탕 can

  15. [Modern methods of diagnosis dyslipidemia ].

    Science.gov (United States)

    Sukhorukov, V N; Karagodin, V P; Orekhov, A N

    2016-01-01

    Dyslipidemia is abnormalities of lipid and lipoprotein metabolism. Most dyslipidemias are hyperlipidemias; that is an abnormally high level of lipids and/or lipoproteins in the blood. Lipid and lipoprotein abnormalities are common in the general population, and are regarded as a modifiable risk factor for cardiovascular disease due to their influence on atherosclerosis. Primary dyslipidemia is usually due to genetic causes, while secondary dyslipidemia arises due to other underlying causes such as diabetes mellitus. Thus, dyslipidemia is an important factor in the development of atherosclerosis and cardiovascular diseases therefore, it is important to diagnose it in time. This review focuses on the modern methods of diagnosis of dyslipidemia.

  16. Radiological methods in liver diagnosis

    International Nuclear Information System (INIS)

    Boeck, N.M.

    1982-01-01

    In 63 localized masses in a group of 169 patients, CT was found to be the most reliable diagnostic method with an accuracy of 97%, a sensitivity of 95%, and a specificity of 97%. With an accuracy of 87%, a sensitivity of 75% and a specificity of 95%, sonography was more efficient than scintiscanning which had an accuracy of 73%, a sensitivity of 71%, and a specificity of 63%. CT and sonography were further compared in a group of 600 patients with 150 proved localized masses. With an accuracy of 82%, a sensitivity of 66% and a specificity of 87%, sonography was clearly inferior to CT which had an accuracy of 97%, a sensitivity of 92%, and a specificity of 98%. CT provided a sure differential diagnosis in 73% of all cases and sonography in 60% (referred to the number of processes detected). Diffuse processes can be detected by radiological methods only at a certain intensity. Here, scintiscanning had a sensitivity of 66%, CT of 53% and somography of 47%. Angiography is indicated for pre-operative determination of the intrahepatic vascular and collateral supply and of the patency of the portal veins. Differential diagnosis is usually reliable. (orig./MG) [de

  17. Constitutional mismatch repair deficiency in a healthy child: On the spot diagnosis?

    Science.gov (United States)

    Suerink, M; Potjer, T P; Versluijs, A B; Ten Broeke, S W; Tops, C M; Wimmer, K; Nielsen, M

    2018-01-01

    Constitutional mismatch repair deficiency (CMMRD) is a rare, recessively inherited childhood cancer predisposition syndrome caused by biallelic germline mutations in one of the mismatch repair genes. The CMMRD phenotype overlaps with that of neurofibromatosis type 1 (NF1), since many patients have multiple café-au-lait macules (CALM) and other NF1 signs, but no germline NF1 mutations. We report of a case of a healthy 6-year-old girl who fulfilled the diagnostic criteria of NF1 with >6 CALM and freckling. Since molecular genetic testing was unable to confirm the diagnosis of NF1 or Legius syndrome and the patient was a child of consanguineous parents, we suspected CMMRD and found a homozygous PMS2 mutation that impairs MMR function. Current guidelines advise testing for CMMRD only in cancer patients. However, this case illustrates that including CMMRD in the differential diagnosis in suspected sporadic NF1 without causative NF1 or SPRED1 mutations may facilitate identification of CMMRD prior to cancer development. We discuss the advantages and potential risks of this CMMRD testing scenario. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  18. Diagnosis of Constitutional Mismatch Repair-Deficiency Syndrome Based on Microsatellite Instability and Lymphocyte Tolerance to Methylating Agents.

    Science.gov (United States)

    Bodo, Sahra; Colas, Chrystelle; Buhard, Olivier; Collura, Ada; Tinat, Julie; Lavoine, Noémie; Guilloux, Agathe; Chalastanis, Alexandra; Lafitte, Philippe; Coulet, Florence; Buisine, Marie-Pierre; Ilencikova, Denisa; Ruiz-Ponte, Clara; Kinzel, Miriam; Grandjouan, Sophie; Brems, Hilde; Lejeune, Sophie; Blanché, Hélène; Wang, Qing; Caron, Olivier; Cabaret, Odile; Svrcek, Magali; Vidaud, Dominique; Parfait, Béatrice; Verloes, Alain; Knappe, Ulrich J; Soubrier, Florent; Mortemousque, Isabelle; Leis, Alexander; Auclair-Perrossier, Jessie; Frébourg, Thierry; Fléjou, Jean-François; Entz-Werle, Natacha; Leclerc, Julie; Malka, David; Cohen-Haguenauer, Odile; Goldberg, Yael; Gerdes, Anne-Marie; Fedhila, Faten; Mathieu-Dramard, Michèle; Hamelin, Richard; Wafaa, Badre; Gauthier-Villars, Marion; Bourdeaut, Franck; Sheridan, Eamonn; Vasen, Hans; Brugières, Laurence; Wimmer, Katharina; Muleris, Martine; Duval, Alex

    2015-10-01

    Patients with bi-allelic germline mutations in mismatch repair (MMR) genes (MLH1, MSH2, MSH6, or PMS2) develop a rare but severe variant of Lynch syndrome called constitutional MMR deficiency (CMMRD). This syndrome is characterized by early-onset colorectal cancers, lymphomas or leukemias, and brain tumors. There is no satisfactory method for diagnosis of CMMRD because screens for mutations in MMR genes are noninformative for 30% of patients. MMR-deficient cancer cells are resistant to genotoxic agents and have microsatellite instability (MSI), due to accumulation of errors in repetitive DNA sequences. We investigated whether these features could be used to identify patients with CMMRD. We examined MSI by PCR analysis and tolerance to methylating or thiopurine agents (functional characteristics of MMR-deficient tumor cells) in lymphoblastoid cells (LCs) from 3 patients with CMMRD and 5 individuals with MMR-proficient LCs (controls). Using these assays, we defined experimental parameters that allowed discrimination of a series of 14 patients with CMMRD from 52 controls (training set). We then used the same parameters to assess 23 patients with clinical but not genetic features of CMMRD. In the training set, we identified parameters, based on MSI and LC tolerance to methylation, that detected patients with CMMRD vs controls with 100% sensitivity and 100% specificity. Among 23 patients suspected of having CMMRD, 6 had MSI and LC tolerance to methylation (CMMRD highly probable), 15 had neither MSI nor LC tolerance to methylation (unlikely to have CMMRD), and 2 were considered doubtful for CMMRD based on having only 1 of the 2 features. The presence of MSI and tolerance to methylation in LCs identified patients with CMMRD with 100% sensitivity and specificity. These features could be used in diagnosis of patients. Copyright © 2015 AGA Institute. Published by Elsevier Inc. All rights reserved.

  19. Modern methods of thyroid diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Hehrmann, R

    1980-11-01

    An attempt is made to provide a systematic general view at the diagnostical methods and facilities which nowadays are applied in the case of thyroid diseases. The reasonable and accurate application of the various methods possible is of decisive importance for the thyroid diagnostics. This planned application requires exact knowledge of the case history and of the findings as well as knowledge of the preconditions, the advantages and disadvantages of and the possible errors in the methods applied. Proposals and guiding lines for a planned step-by-step application of methods of diagnosing thyroid diseases were published by the Section Thyroid Society for Endocrinology in Wiesbaden in December 1978. For step-by-step diagnostics of thyroid diseaeses, these publications may be of help.

  20. Imaging methods in medical diagnosis

    International Nuclear Information System (INIS)

    Krestel, E.

    1981-01-01

    Pictures of parts of the human body or of the human body (views, superposition pictures, pictures of body layers, or photographs) are considerable helps for the medical diagnostics. Physics, electrotechnique, and machine construction make the picture production possible. Modern electronics and optics offer facilities of picture processing which influences the picture quality. Picture interpretation is the the physican's task. The picture-delivering methods applied in medicine include the conventional X-ray diagnostics, X-ray computer tomography, nuclear diagnostics, sonography with ultas sound, and endoscopy. Their rapid development and immprovement was caused by the development of electronics during the past 20 years. A method presently in discussion and development is the Kernspin-tomography. (orig./MG) [de

  1. Constitutional mismatch repair deficiency in a healthy child : On the spot diagnosis?

    NARCIS (Netherlands)

    Suerink, Manon; Potjer, Thomas P.; Versluijs, A. B.; Ten Broeke, Sanne W.; Tops, Carli M.; Wimmer, K.; Nielsen, M.

    2018-01-01

    Constitutional mismatch repair deficiency (CMMRD) is a rare, recessively inherited childhood cancer predisposition syndrome caused by biallelic germline mutations in one of the mismatch repair genes. The CMMRD phenotype overlaps with that of neurofibromatosis type 1 (NF1), since many patients have

  2. Fault diagnosis methods for district heating substations

    Energy Technology Data Exchange (ETDEWEB)

    Pakanen, J.; Hyvaerinen, J.; Kuismin, J.; Ahonen, M. [VTT Building Technology, Espoo (Finland). Building Physics, Building Services and Fire Technology

    1996-12-31

    A district heating substation is a demanding process for fault diagnosis. The process is nonlinear, load conditions of the district heating network change unpredictably and standard instrumentation is designed only for control and local monitoring purposes, not for automated diagnosis. Extra instrumentation means additional cost, which is usually not acceptable to consumers. That is why all conventional methods are not applicable in this environment. The paper presents five different approaches to fault diagnosis. While developing the methods, various kinds of pragmatic aspects and robustness had to be considered in order to achieve practical solutions. The presented methods are: classification of faults using performance indexing, static and physical modelling of process equipment, energy balance of the process, interactive fault tree reasoning and statistical tests. The methods are applied to a control valve, a heat excharger, a mud separating device and the whole process. The developed methods are verified in practice using simulation, simulation or field tests. (orig.) (25 refs.)

  3. Advanced methods in diagnosis and therapy

    International Nuclear Information System (INIS)

    1987-01-01

    This important meeting covers the following topics: use and optimization of monoclonal antibobies in oncology: - Tumor markers: Clinical follow-up of patients through tumor marker serum determinations. - Cancer and medical imaging: The use of monoclonal antibodies in immunoscintigraphy. - Immunoradiotherapy: Monoclonal antibodies as therapeutic vectors. Advanced methods in diagnosis: - Contribution of monoclonal antibodies in modern immunochemistry (RIA, EIA). - Interest of monoclonal antibody in immunohistochemical pathology diagnosis. - In vitro diagnosis future prospects: with receptors and oncogenes. - Immunofluoroassay: a new sensitive immunoanalytical procedure with broad applications. Recent advances in brachitherapy: - Interest of computer processing. Blood products irradiation: - Interest in transfusion and bone marrow transplantations [fr

  4. Methods to isolate extracellular vesicles for diagnosis

    Science.gov (United States)

    Kang, Hyejin; Kim, Jiyoon; Park, Jaesung

    2017-12-01

    Extracellular vesicles (EVs) are small membrane-bound bodies that are released into extracellular space by diverse cells, and are found in body fluids like blood, urine and saliva. EVs contain RNA, DNA and proteins, which can be biomarkers for diagnosis. EVs can be obtained by minimally-invasive biopsy, so they are useful in disease diagnosis. High yield and purity contribute to precise diagnosis of disease, but damaged EVs and impurities can cause confu sed results. However, EV isolation methods have different yields and purities. Furthermore, the isolation method that is most suitable to maximize EV recovery efficiency depends on the experimental conditions. This review focuses on merits and demerits of several types of EV isolation methods, and provides examples of how to diagnose disease by exploiting information obtained by analysis of EVs.

  5. Method to determine the optimal constitutive model from spherical indentation tests

    Directory of Open Access Journals (Sweden)

    Tairui Zhang

    2018-03-01

    Full Text Available The limitation of current indentation theories was investigated and a method to determine the optimal constitutive model through spherical indentation tests was proposed. Two constitutive models, the Power-law and the Linear-law, were used in Finite Element (FE calculations, and then a set of indentation governing equations was established for each model. The load-depth data from the normal indentation depth was used to fit the best parameters in each constitutive model while the data from the further loading part was compared with those from FE calculations, and the model that better predicted the further deformation was considered the optimal one. Moreover, a Yang’s modulus calculation model which took the previous plastic deformation and the phenomenon of pile-up (or sink-in into consideration was also proposed to revise the original Sneddon-Pharr-Oliver model. The indentation results on six materials, 304, 321, SA508, SA533, 15CrMoR, and Fv520B, were compared with tensile ones, which validated the reliability of the revised E calculation model and the optimal constitutive model determination method in this study. Keywords: Optimal constitutive model, Spherical indentation test, Finite Element calculations, Yang’s modulus

  6. Constituting the Field: An Essay on Harry Torrance's "Qualitative Research Methods in Education"

    Science.gov (United States)

    Dimitriadis, Greg

    2011-01-01

    This article critically explores Harry Torrance's four-volume edited collection "Qualitative Research Methods in Education." The author argues that this text is an important intervention in the constitution of a meta-discourse on qualitative research today. Torrance pays particular attention to the field of education, providing much needed…

  7. A method for the quantification of biased signalling at constitutively active receptors.

    Science.gov (United States)

    Hall, David A; Giraldo, Jesús

    2018-06-01

    Biased agonism, the ability of an agonist to differentially activate one of several signal transduction pathways when acting at a given receptor, is an increasingly recognized phenomenon at many receptors. The Black and Leff operational model lacks a way to describe constitutive receptor activity and hence inverse agonism. Thus, it is impossible to analyse the biased signalling of inverse agonists using this model. In this theoretical work, we develop and illustrate methods for the analysis of biased inverse agonism. Methods were derived for quantifying biased signalling in systems that demonstrate constitutive activity using the modified operational model proposed by Slack and Hall. The methods were illustrated using Monte Carlo simulations. The Monte Carlo simulations demonstrated that, with an appropriate experimental design, the model parameters are 'identifiable'. The method is consistent with methods based on the measurement of intrinsic relative activity (RA i ) (ΔΔlogR or ΔΔlog(τ/K a )) proposed by Ehlert and Kenakin and their co-workers but has some advantages. In particular, it allows the quantification of ligand bias independently of 'system bias' removing the requirement to normalize to a standard ligand. In systems with constitutive activity, the Slack and Hall model provides methods for quantifying the absolute bias of agonists and inverse agonists. This provides an alternative to methods based on RA i and is complementary to the ΔΔlog(τ/K a ) method of Kenakin et al. in systems where use of that method is inappropriate due to the presence of constitutive activity. © 2018 The British Pharmacological Society.

  8. The Virtual Fields Method Extracting Constitutive Mechanical Parameters from Full-field Deformation Measurements

    CERN Document Server

    Pierron, Fabrice

    2012-01-01

    The Virtual Fields Method: Extracting Constitutive Mechanical Parameters from Full-field Deformation Measurements is the first book on the Virtual Fields Method (VFM), a technique to identify materials mechanical properties from full-field measurements. Firmly rooted with extensive theoretical description of the method, the book presents numerous examples of application to a wide range of materials (composites, metals, welds, biomaterials) and situations (static, vibration, high strain rate). The authors give a detailed training section with examples of progressive difficulty to lead the reader to program the VFM and include a set of commented Matlab programs as well as GUI Matlab-based software for more general situations. The Virtual Fields Method: Extracting Constitutive Mechanical Parameters from Full-field Deformation Measurements is an ideal book for researchers, engineers, and students interested in applying the VFM to new situations motivated by their research.  

  9. Method to determine the optimal constitutive model from spherical indentation tests

    Science.gov (United States)

    Zhang, Tairui; Wang, Shang; Wang, Weiqiang

    2018-03-01

    The limitation of current indentation theories was investigated and a method to determine the optimal constitutive model through spherical indentation tests was proposed. Two constitutive models, the Power-law and the Linear-law, were used in Finite Element (FE) calculations, and then a set of indentation governing equations was established for each model. The load-depth data from the normal indentation depth was used to fit the best parameters in each constitutive model while the data from the further loading part was compared with those from FE calculations, and the model that better predicted the further deformation was considered the optimal one. Moreover, a Yang's modulus calculation model which took the previous plastic deformation and the phenomenon of pile-up (or sink-in) into consideration was also proposed to revise the original Sneddon-Pharr-Oliver model. The indentation results on six materials, 304, 321, SA508, SA533, 15CrMoR, and Fv520B, were compared with tensile ones, which validated the reliability of the revised E calculation model and the optimal constitutive model determination method in this study.

  10. Numerical investigations on contactless methods for measuring critical current density in HTS: application of modified constitutive-relation method

    International Nuclear Information System (INIS)

    Kamitani, A.; Takayama, T.; Itoh, T.; Ikuno, S.

    2011-01-01

    A fast method is proposed for calculating the shielding current density in an HTS. The J-E constitutive relation is modified so as not to change the solution. A numerical code is developed on the basis of the proposed method. The permanent magnet method is successfully simulated by means of the code. A fast method has been proposed for calculating the shielding current density in a high-temperature superconducting thin film. An initial-boundary-value problem of the shielding current density cannot be always solved by means of the Runge-Kutta method even when an adaptive step-size control algorithm is incorporated to the method. In order to suppress an overflow in the algorithm, the J-E constitutive relation is modified so that its solution may satisfy the original constitutive relation. A numerical code for analyzing the shielding current density has been developed on the basis of this method and, as an application of the code, the permanent magnet method for measuring the critical current density has been investigated numerically.

  11. A dynamic integrated fault diagnosis method for power transformers.

    Science.gov (United States)

    Gao, Wensheng; Bai, Cuifen; Liu, Tong

    2015-01-01

    In order to diagnose transformer fault efficiently and accurately, a dynamic integrated fault diagnosis method based on Bayesian network is proposed in this paper. First, an integrated fault diagnosis model is established based on the causal relationship among abnormal working conditions, failure modes, and failure symptoms of transformers, aimed at obtaining the most possible failure mode. And then considering the evidence input into the diagnosis model is gradually acquired and the fault diagnosis process in reality is multistep, a dynamic fault diagnosis mechanism is proposed based on the integrated fault diagnosis model. Different from the existing one-step diagnosis mechanism, it includes a multistep evidence-selection process, which gives the most effective diagnostic test to be performed in next step. Therefore, it can reduce unnecessary diagnostic tests and improve the accuracy and efficiency of diagnosis. Finally, the dynamic integrated fault diagnosis method is applied to actual cases, and the validity of this method is verified.

  12. A Dynamic Integrated Fault Diagnosis Method for Power Transformers

    Science.gov (United States)

    Gao, Wensheng; Liu, Tong

    2015-01-01

    In order to diagnose transformer fault efficiently and accurately, a dynamic integrated fault diagnosis method based on Bayesian network is proposed in this paper. First, an integrated fault diagnosis model is established based on the causal relationship among abnormal working conditions, failure modes, and failure symptoms of transformers, aimed at obtaining the most possible failure mode. And then considering the evidence input into the diagnosis model is gradually acquired and the fault diagnosis process in reality is multistep, a dynamic fault diagnosis mechanism is proposed based on the integrated fault diagnosis model. Different from the existing one-step diagnosis mechanism, it includes a multistep evidence-selection process, which gives the most effective diagnostic test to be performed in next step. Therefore, it can reduce unnecessary diagnostic tests and improve the accuracy and efficiency of diagnosis. Finally, the dynamic integrated fault diagnosis method is applied to actual cases, and the validity of this method is verified. PMID:25685841

  13. Constitutive Modelling in Thermomechanical Processes, Using The Control Volume Method on Staggered Grid

    DEFF Research Database (Denmark)

    Thorborg, Jesper

    , however, is constituted by the implementation of the $J_2$ flow theory in the control volume method. To apply the control volume formulation on the process of hardening concrete viscoelastic stress-strain models has been examined in terms of various rheological models. The generalized 3D models are based...... on two different suggestions in the literature, that is compressible or incompressible behaviour of the viscos response in the dashpot element. Numerical implementation of the models has shown very good agreement with corresponding analytical solutions. The viscoelastic solid mechanical model is used...

  14. Contribution of MLH1 constitutional methylation for Lynch syndrome diagnosis in patients with tumor MLH1 downregulation.

    Science.gov (United States)

    Pinto, Diana; Pinto, Carla; Guerra, Joana; Pinheiro, Manuela; Santos, Rui; Vedeld, Hege Marie; Yohannes, Zeremariam; Peixoto, Ana; Santos, Catarina; Pinto, Pedro; Lopes, Paula; Lothe, Ragnhild; Lind, Guro Elisabeth; Henrique, Rui; Teixeira, Manuel R

    2018-02-01

    Constitutional epimutation of the two major mismatch repair genes, MLH1 and MSH2, has been identified as an alternative mechanism that predisposes to the development of Lynch syndrome. In the present work, we aimed to investigate the prevalence of MLH1 constitutional methylation in colorectal cancer (CRC) patients with abnormal expression of the MLH1 protein in their tumors. In a series of 38 patients who met clinical criteria for Lynch syndrome genetic testing, with loss of MLH1 expression in the tumor and with no germline mutations in the MLH1 gene (35/38) or with tumors presenting the BRAF p.Val600Glu mutation (3/38), we screened for constitutional methylation of the MLH1 gene promoter using methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) in various biological samples. We found four (4/38; 10.5%) patients with constitutional methylation in the MLH1 gene promoter. RNA studies demonstrated decreased MLH1 expression in the cases with constitutional methylation when compared with controls. We could infer the mosaic nature of MLH1 constitutional hypermethylation in tissues originated from different embryonic germ layers, and in one family we could show that it occurred de novo. We conclude that constitutional MLH1 methylation occurs in a significant proportion of patients who have loss of MLH1 protein expression in their tumors and no MLH1 pathogenic germline mutation. Furthermore, we provide evidence that MLH1 constitutional hypermethylation is the molecular mechanism behind about 3% of Lynch syndrome families diagnosed in our institution, especially in patients with early onset or multiple primary tumors without significant family history. © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

  15. The constitutive compatibility method for identification of material parameters based on full-field measurements

    KAUST Repository

    Moussawi, Ali; Lubineau, Gilles; Florentin, É ric; Blaysat, Benoî t

    2013-01-01

    We revisit here the concept of the constitutive relation error for the identification of elastic material parameters based on image correlation. An additional concept, so called constitutive compatibility of stress, is introduced defining a subspace

  16. Identification of the parameters of an elastic material model using the constitutive equation gap method

    KAUST Repository

    Florentin, Éric

    2010-04-23

    Today, the identification ofmaterialmodel parameters is based more and more on full-field measurements. This article explains how an appropriate use of the constitutive equation gap method (CEGM) can help in this context. The CEGM is a well-known concept which, until now, has been used mainly for the verification of finite element simulations. This has led to many developments, especially concerning the techniques for constructing statically admissible stress fields. The originality of the present study resides in the application of these recent developments to the identification problem. The proposed CEGM is described in detail, then evaluated through the identification of heterogeneous isotropic elastic properties. The results obtained are systematically compared with those of the equilibrium gap method, which is a well-known technique for the resolution of such identification problems. We prove that the use of the enhanced CEGM significantly improves the quality of the results. © Springer-Verlag 2010.

  17. Thermal constitutive matrix applied to asynchronous electrical machine using the cell method

    Science.gov (United States)

    Domínguez, Pablo Ignacio González; Monzón-Verona, José Miguel; Rodríguez, Leopoldo Simón; Sánchez, Adrián de Pablo

    2018-03-01

    This work demonstrates the equivalence of two constitutive equations. One is used in Fourier's law of the heat conduction equation, the other in electric conduction equation; both are based on the numerical Cell Method, using the Finite Formulation (FF-CM). A 3-D pure heat conduction model is proposed. The temperatures are in steady state and there are no internal heat sources. The obtained results are compared with an equivalent model developed using the Finite Elements Method (FEM). The particular case of 2-D was also studied. The errors produced are not significant at less than 0.2%. The number of nodes is the number of the unknowns and equations to resolve. There is no significant gain in precision with increasing density of the mesh.

  18. Constitutive Investigation on Viscoelasticity of PolyVinyl Butyral: Experiments Based on Dynamic Mechanical Analysis Method

    Directory of Open Access Journals (Sweden)

    Bohan Liu

    2014-01-01

    Full Text Available PolyVinyl Butyral (PVB film is now widely used in automotive industry and architectures serving as the protective interlayer. The dynamic modulus of PVB is measured through systematic experiments based on Dynamic Mechanical Analysis (DMA method at various temperatures, heating rates, and vibration frequencies. Further, viscoelasticity of PVB influenced by time and temperature is systematically studied. Fitted empirical formulas describing the relationship between glass transition temperature and frequency, as well as the heating rate of PVB, are established. The master curve of PVB at 293 K is suggested based on the experiment data as to express the dynamic modulus variation at various frequencies in a wider range. Constitutive behavior of PVB is then analyzed based on Generalized Maxwell (GM model and Fractional Derivative (FD model, respectively. It is shown that PVB has higher efficiency of energy dissipation in its high energy absorption state, while both fifth-order GM model and FD model can characterize the viscoelasticity of PVB at glassy transition area. Results may offer useful fundamental experimental data and important constitutive characteristics of PVB and shed lights on further studies on viscoelasticity behavior of PVB and energy mitigation ability of laminated glass.

  19. Grading of methods of thyroid diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Pfannenstiel, P [Stiftung Deutsche Klinik fuer Diagnostik, Wiesbaden (Germany, F.R.). Fachbereich Nuklearmedizin

    1980-09-24

    After anamnesis and physical examination, the first step in thyroid diagnosis is the determination of serum thyroxine, if necessary together with a parameter to determine the free thyroxine. If the findings are still unclear and if hypo- or hyperthyroidism are suspected, triiodothyronine determination, the TSH-TRH test, and in some cases also the two-phase radioiodine test are applied. The functional diagnosis is supplemented by thyroid scintiscanning, with the aid of short-lived radionuclides, e.g. /sup 99/sup(m)Tc-O/sub 4/ or /sup 123/I. If an autonomous transformation of part of the thyroid is suspected, scintiscanning is repeated after suppression of the thyroid by thyroid hormone. If scintiscanning has shown a cold area inside the thyroid, biopsy followed by a cytological evaluation of the aspirate is indicated. Depending on the suspected clinical diagnosis, the available tests should be used carefully and efficiently for the initial diagnosis as well as for course control of thyroid diseases.

  20. Using constitutive equation gap method for identification of elastic material parameters: Technical insights and illustrations

    KAUST Repository

    Florentin, Éric

    2011-08-09

    The constitutive equation gap method (CEGM) is a well-known concept which, until now, has been used mainly for the verification of finite element simulations. Recently, CEGM-based functional has been proposed to identify local elastic parameters based on experimental full-field measurement. From a technical point of view, this approach requires to quickly describe a space of statically admissible stress fields. We present here the technical insights, inspired from previous works in verification, that leads to the construction of such a space. Then, the identification strategy is implemented and the obtained results are compared with the actual material parameters for numerically generated benchmarks. The quality of the identification technique is demonstrated that makes it a valuable tool for interactive design as a way to validate local material properties. © 2011 Springer-Verlag.

  1. Constitutive modeling of two phase materials using the Mean Field method for homogenization

    NARCIS (Netherlands)

    Perdahcioglu, Emin Semih; Geijselaers, Hubertus J.M.

    2010-01-01

    A Mean-Field homogenization framework for constitutive modeling of materials involving two distinct elastic-plastic phases is presented. With this approach it is possible to compute the macroscopic mechanical behavior of this type of materials based on the constitutive models of the constituent

  2. Cancer Detection and Diagnosis Methods - Annual Plan

    Science.gov (United States)

    Early cancer detection is a proven life-saving strategy. Learn about the research opportunities NCI supports, including liquid biopsies and other less-invasive methods, for detecting early cancers and precancerous growths.

  3. Nuclear Power Plants Fault Diagnosis Method Based on Data Fusion

    International Nuclear Information System (INIS)

    Xie Chunli; Liu Yongkuo; Xia Hong

    2009-01-01

    The data fusion is a method suit for complex system fault diagnosis such as nuclear power plants, which is multisource information processing technology. This paper uses data fusion information hierarchical thinking and divides nuclear power plants fault diagnosis into three levels. Data level adopts data mining method to handle data and reduction attributes. Feature level uses three parallel neural networks to deal with attributes of data level reduction and the outputs of three networks are as the basic probability assignment of Dempster-Shafer (D-S) evidence theory. The improved D-S evidence theory synthesizes the outputs of neural networks in decision level, which conquer the traditional D-S evidence theory limitation which can't dispose conflict information. The diagnosis method was tested using correlation data of literature. The test results indicate that the data fusion diagnosis system can diagnose nuclear power plants faults accurately and the method has application value. (authors)

  4. A Fuzzy Method for Medical Diagnosis of Headache

    Science.gov (United States)

    Ahn, Jeong-Yong; Mun, Kill-Sung; Kim, Young-Hyun; Oh, Sun-Young; Han, Beom-Soo

    In this note we propose a fuzzy diagnosis of headache. The method is based on the relations between symptoms and diseases. For this purpose, we suggest a new diagnosis measure using the occurrence information of patient's symptoms and develop an improved interview chart with fuzzy degrees assigned according to the relation among symptoms and three labels of headache. The proposed method is illustrated by two examples.

  5. Molecular methods for diagnosis of odontogenic infections.

    Science.gov (United States)

    Flynn, Thomas R; Paster, Bruce J; Stokes, Lauren N; Susarla, Srinivas M; Shanti, Rabie M

    2012-08-01

    Historically, the identification of microorganisms has been limited to species that could be cultured in the microbiology laboratory. The purpose of the present study was to apply molecular techniques to identify microorganisms in orofacial odontogenic infections (OIs). Specimens were obtained from subjects with clinical evidence of OI. To identify the microorganisms involved, 16S rRNA sequencing methods were used on clinical specimens. The name and number of the clones of each species identified and the combinations of species present were recorded for each subject. Descriptive statistics were computed for the study variables. Specimens of pus or wound fluid were obtained from 9 subjects. A mean of 7.4 ± 3.7 (standard deviation) species per case were identified. The predominant species detected in the present study that have previously been associated with OIs were Fusobacterium spp, Parvimonas micra, Porphyromonas endodontalis, and Prevotella oris. The predominant species detected in our study that have not been previously associated with OIs were Dialister pneumosintes and Eubacterium brachy. Unculturable phylotypes accounted for 24% of the species identified in our study. All species detected were obligate or facultative anaerobes. Streptococci were not detected. Molecular methods have enabled us to detect previously cultivated and not-yet-cultivated species in OIs; these methods could change our understanding of the pathogenic flora of orofacial OIs. Copyright © 2012 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  6. Doppler and ultrasound methods for diagnosis.

    Science.gov (United States)

    Strandness, D E

    2000-09-01

    With the availability of ultrasonic duplex scanning we now have a method of safely screening those patients who may be thought to have renal artery stenosis as the basis for hypertension or renal failure. Modern instrumentation combined with an experienced technologist makes this a reasonable and accurate screening test. One of its major advantages is that it can be used for repeat studies to document the outcome of any form of intervention designed to remove or bypass areas of stenosis. We no longer need to wonder if a reconstruction has been successful or not. Another great advantage is its role in documenting both the degree of narrowing and its effect on kidney size. It is now known, because of information obtained with this technology, that high-grade renal artery stenoses are accompanied by a decrease in kidney size. It is also possible to document disease progression with atherosclerotic involvement of the renal arteries. With more widespread use of this method, we will be able to obtain useful information on how renal artery disease should be treated and monitored.

  7. The constitutive compatibility method for identification of material parameters based on full-field measurements

    KAUST Repository

    Moussawi, Ali

    2013-10-01

    We revisit here the concept of the constitutive relation error for the identification of elastic material parameters based on image correlation. An additional concept, so called constitutive compatibility of stress, is introduced defining a subspace of the classical space of statically admissible stresses. The key idea is to define stresses as compatible with the observed deformation field through the chosen class of constitutive equation. This makes possible the uncoupling of the identification of stress from the identification of the material parameters. As a result, the global cost of the identification is strongly reduced. This uncoupling also leads to parametrized solutions in cases where the solution is non-unique as demonstrated on 2D numerical examples. © 2013 Elsevier B.V.

  8. Plasma diagnosis using the Hook method, 2

    International Nuclear Information System (INIS)

    Horiguchi, Shiro; Ninomiya, Hideki; Osumi, Hiroshi; Nakaya, Toshizo

    1978-01-01

    This paper deals with the measurement of the population of metastable Hg atoms in pulsed discharge by the Hook method, and the experimental results are described in connection with the time relation, then comparison of the experimental results with the numerical calculation based on the rate equation is also made. The optical setup for the Hook method consists of a Mach-Zehnder interferometer, an Ebert-mount spectrograph of 180 cm focal length with a grating of 1200 groves/mm blazed at 5000 x 10 -8 cm and a dye laser pumped by N 2 laser as a light source for the interferometer. The discharge tube is placed in one of the arms of the interferometer. In order to examine plasma at the various stage of discharge, the N 2 laser was operated by the trigger pulses with predetermined delay time. In order to study the time variation of the population densities of Hg (6 3 P 2 , P 1 and P 0 ) levels, the Hook spectrograms were taken. It is evident that the population densities of low-lying excited Hg levels begin to increase rapidly up to a maximum within 1 microsec, and then gradually decrease. A set of the rate equations describing the population of the ions, the metastable state Hg atoms and the ground state Hg atoms is introduced. As the results of numerical calculation, the variation of the population is obtained. The time at which the population is maximum depends not only on the coefficient of excitation from ground state to metastable states, but also on the coefficient of stepwise excitation. (Kato, T.)

  9. Ontology-Based Method for Fault Diagnosis of Loaders.

    Science.gov (United States)

    Xu, Feixiang; Liu, Xinhui; Chen, Wei; Zhou, Chen; Cao, Bingwei

    2018-02-28

    This paper proposes an ontology-based fault diagnosis method which overcomes the difficulty of understanding complex fault diagnosis knowledge of loaders and offers a universal approach for fault diagnosis of all loaders. This method contains the following components: (1) An ontology-based fault diagnosis model is proposed to achieve the integrating, sharing and reusing of fault diagnosis knowledge for loaders; (2) combined with ontology, CBR (case-based reasoning) is introduced to realize effective and accurate fault diagnoses following four steps (feature selection, case-retrieval, case-matching and case-updating); and (3) in order to cover the shortages of the CBR method due to the lack of concerned cases, ontology based RBR (rule-based reasoning) is put forward through building SWRL (Semantic Web Rule Language) rules. An application program is also developed to implement the above methods to assist in finding the fault causes, fault locations and maintenance measures of loaders. In addition, the program is validated through analyzing a case study.

  10. Pregnancy diagnosis in sheep: review of the most practical methods

    International Nuclear Information System (INIS)

    Karen, A.; Szenci, O.; Kovacs, P.; Beckers, J.F.

    2001-01-01

    Various practical methods have been used for pregnancy diagnosis in sheep: radiography, rectal abdominal palpation, assessment of progesterone, assessment of estrone sulphate, RIA assay of placental lactogen, assessment of pregnancy proteins or pregnancy-associated glycoproteins, A-mode ultrasound, Doppler ultrasound and real-time B-mode ultrasonography. Real-time, B-mode ultrasonography appears to be the most practical and accurate method for diagnosing pregnancy and determining fetal numbers in sheep. Transabdominal B-mode ultrasonography achieved high accuracy for pregnancy diagnosis (94-100 %) and the determination of fetal numbers (92-99 %) on d 29 to 106 of gestation

  11. Comparison of the Methods for the Diagnosis of Onychomycosis

    Directory of Open Access Journals (Sweden)

    Banu Bayraktar

    2008-10-01

    Full Text Available Background and Design: A potassium hydroxide (KOH direct microscopic examination, histopathological investigation with periodic acid-Schiff (PAS stain and fungal culture are common diagnostic methods in the diagnosis of onychomycosis. The purpose of this study was to compare these three methods for the diagnosis of onychomycosis.Material and Method: A total of 100 patients who were suspected clinically of having onychomycosis on their toenails were included in this study. Three diagnostic tests were performed for each patients. In addition to clinical suspicion when one of the diagnostic tests was positive the diagnosis of onychomycosis was made. Accordingly, the sensitivity and the negative predictive value were calculated for each diagnostic test.Results: In 92 (92% of the patients, at least one of the three diagnostic methods was positive. The sensitivites of these methods were as follows: KOH direct microscopic examination, 92%; histopathological investigation with PAS stain, 80%; and culture, 20%. Their negative predictive values were also 53%, 42%, and 10% respectively. Conclusion: KOH direct microscopic examination is the most sensitive method for the diagnosis of onychomycosis. Its high negative predictive value supports this finding. (Turkderm 2008; 42: 91-3

  12. Compositions, antibodies, asthma diagnosis methods, and methods for preparing antibodies

    Energy Technology Data Exchange (ETDEWEB)

    Jin, Hongjun; Zangar, Richard C.

    2017-01-17

    Methods for preparing an antibody are provided with the method including incorporating 3-bromo-4-hydroxy-benzoic acid into a protein to form an antigen, immunizing a mammalian host with the antigen, and recovering an antibody having an affinity for the antigen from the host. Antibodies having a binding affinity for a monohalotyrosine are provided as well as composition comprising an antibody bound with monohalotyrosine. Compositions comprising a protein having a 3-bromo-4-hydroxy-benzoic acid moiety are also provided. Methods for evaluating the severity of asthma are provide with the methods including analyzing sputum of a patient using an antibody having a binding affinity for monohalotyrosine, and measuring the amount of antibody bound to protein. Methods for determining eosinophil activity in bodily fluid are also provided with the methods including exposing bodily fluid to an antibody having a binding affinity for monohalotyrosine, and measuring the amount of bound antibody to determine the eosinophil activity.

  13. Methods of Helminthiasis Diagnosis at the Present Stage

    Directory of Open Access Journals (Sweden)

    I.B. Yershova

    2014-04-01

    Full Text Available The article describes the methods of diagnosis of helminth infestations: microscopic, immunoenzyme analysis, serology, polymerase chain reaction, bioresonance diagnostics, haemoscanning, as well as instrumental methods (ultrasound and X-ray examination, computed tomography and laboratory analysis of indirect value (complete blood count, liver function tests, fecal dysbiosis. Advantages of methods, as well as disadvantages, the reliability of the findings are described. Questionnaire for patients are offered to determine the risk of helminth infestation.

  14. A Fast Kurtogram Demodulation Method in Rolling Bearing Fault Diagnosis

    Directory of Open Access Journals (Sweden)

    Li Li

    2016-01-01

    Full Text Available Targeting at the problem of finding the best demodulation band when applying envelope analysis in rolling bearing fault diagnosis, this paper proposes a novel Fast Kurtogram Demodulation Method (FKDM to solve the problem. FKDM is established based on the theory of spectrum kurtosis and the short-time Fourier Transform. It determines the best demodulation band firstly, which is also known as the central frequency and frequency resolution. Then, the fault signals can be demodulated in the obtained frequency band by using envelope demodulation algorithm. The FKDM method ensures the fault diagnosis correction by solving the problem of demodulation band selection. Applied FKDM in rolling bearing fault diagnosis and compared with conventional envelope analysis, the results demonstrate FKDM can achieve a better performance.

  15. Accuracy-enhanced constitutive parameter identification using virtual fields method and special stereo-digital image correlation

    Science.gov (United States)

    Zhang, Zhongya; Pan, Bing; Grédiac, Michel; Song, Weidong

    2018-04-01

    The virtual fields method (VFM) is generally used with two-dimensional digital image correlation (2D-DIC) or grid method (GM) for identifying constitutive parameters. However, when small out-of-plane translation/rotation occurs to the test specimen, 2D-DIC and GM are prone to yield inaccurate measurements, which further lessen the accuracy of the parameter identification using VFM. In this work, an easy-to-implement but effective "special" stereo-DIC (SS-DIC) method is proposed for accuracy-enhanced VFM identification. The SS-DIC can not only deliver accurate deformation measurement without being affected by unavoidable out-of-plane movement/rotation of a test specimen, but can also ensure evenly distributed calculation data in space, which leads to simple data processing. Based on the accurate kinematics fields with evenly distributed measured points determined by SS-DIC method, constitutive parameters can be identified by VFM with enhanced accuracy. Uniaxial tensile tests of a perforated aluminum plate and pure shear tests of a prismatic aluminum specimen verified the effectiveness and accuracy of the proposed method. Experimental results show that the constitutive parameters identified by VFM using SS-DIC are more accurate and stable than those identified by VFM using 2D-DIC. It is suggested that the proposed SS-DIC can be used as a standard measuring tool for mechanical identification using VFM.

  16. Methods for Instructional Diagnosis with Limited Available Resources.

    Science.gov (United States)

    Gillmore, Gerald M.; Clark, D. Joseph

    College teaching should be approached with the same careful delineation of problems and systematic attempts to find solutions which characterize research. Specific methods for the diagnosis of instructional problems include audio-video taping, use of teaching assistants, colleague assistance, classroom tests, student projects in and out of class,…

  17. Laboratory methods for diagnosis and detection of drug resistant ...

    African Journals Online (AJOL)

    Data source: Published series of peer reviewed journals and manuals written on laboratory methods that are currently used for diagnosis and detection of drug resistance of Mycobacterium tuberculosis complex were reviewed using the index medicus, pubmed and medline search. Conventional bacteriological microscopy ...

  18. Influence of constitutive equations and calculation methods on the results of inelastic analysis of benchmark problems

    International Nuclear Information System (INIS)

    Konter, A.W.A.; Kusters, G.M.A.

    1981-01-01

    Several constitutive equations are used to analyse the structural behaviour of a simply supported beam and circular plate loaded at its center, both tested at 1100 0 F. The time-independent plastic behaviour has been analysed with the isotropic and kinematic hardening model as well as with the ORNL 10th cycle model and the fraction model of Besseling. The time-dependent creep behaviour has been analysed using the isotropic hardening rules and the ORNL auxiliary hardening rules. No interaction of the creep and plastic behaviour was taken into account. Especially for cyclic loading conditions, large differences occur in the predictions of the inelastic behaviour. Good agreement between theory and prediction can be obtained with models which accurately account for the ratio of kinematic and saturating isotropic hardening of the used material. (orig./HP)

  19. Two-step Raman spectroscopy method for tumor diagnosis

    Science.gov (United States)

    Zakharov, V. P.; Bratchenko, I. A.; Kozlov, S. V.; Moryatov, A. A.; Myakinin, O. O.; Artemyev, D. N.

    2014-05-01

    Two-step Raman spectroscopy phase method was proposed for differential diagnosis of malignant tumor in skin and lung tissue. It includes detection of malignant tumor in healthy tissue on first step with identification of concrete cancer type on the second step. Proposed phase method analyze spectral intensity alteration in 1300-1340 and 1640-1680 cm-1 Raman bands in relation to the intensity of the 1450 cm-1 band on first step, and relative differences between RS intensities for tumor area and healthy skin closely adjacent to the lesion on the second step. It was tested more than 40 ex vivo samples of lung tissue and more than 50 in vivo skin tumors. Linear Discriminant Analysis, Quadratic Discriminant Analysis and Support Vector Machine were used for tumors type classification on phase planes. It is shown that two-step phase method allows to reach 88.9% sensitivity and 87.8% specificity for malignant melanoma diagnosis (skin cancer); 100% sensitivity and 81.5% specificity for adenocarcinoma diagnosis (lung cancer); 90.9% sensitivity and 77.8% specificity for squamous cell carcinoma diagnosis (lung cancer).

  20. Galactoscopy - is it a new interventional method for breast diagnosis?

    International Nuclear Information System (INIS)

    Schulz-Wendtland, R.; Aichinger, U.; Tartsch, M.; Bautz, W.; Schaaf, H.

    2002-01-01

    Based on experimental studies with animals we examined 22 patients with pathological (bloody) nipple discharge by cryotology, ultrasonography, galactography and the newly developed galactoscopy [Endoscopic-System EndoGnost trademark (Polydiagnost)]. The duct's cannula has an outer/inner diameter of 0.45 mm/0.36 mm and a working length of 30 mm, the endoscope a length of 1200 mm, adapted to a CCD-camera (2500 pixel). All patients underwent surgery and histo-pathological diagnosis. The best diagnostic results were received with galactoscopy (21/22). By using an additional cutter it is possible to obtain a histological sample for diagnosis endoscopically. Galactoscopy is an emerging technique and will expand the spectrum of interventional methods in breast diagnosis. (orig.) [de

  1. Method of dynamic fuzzy symptom vector in intelligent diagnosis

    International Nuclear Information System (INIS)

    Sun Hongyan; Jiang Xuefeng

    2010-01-01

    Aiming at the requirement of diagnostic symptom real-time updating brought from diagnostic knowledge accumulation and great gap in unit and value of diagnostic symptom in multi parameters intelligent diagnosis, the method of dynamic fuzzy symptom vector is proposed. The concept of dynamic fuzzy symptom vector is defined. Ontology is used to specify the vector elements, and the vector transmission method based on ontology is built. The changing law of symptom value is analyzed and fuzzy normalization method based on fuzzy membership functions is built. An instance proved method of dynamic fussy symptom vector is efficient to solve the problems of symptom updating and unify of symptom value and unit. (authors)

  2. Unsupervised process monitoring and fault diagnosis with machine learning methods

    CERN Document Server

    Aldrich, Chris

    2013-01-01

    This unique text/reference describes in detail the latest advances in unsupervised process monitoring and fault diagnosis with machine learning methods. Abundant case studies throughout the text demonstrate the efficacy of each method in real-world settings. The broad coverage examines such cutting-edge topics as the use of information theory to enhance unsupervised learning in tree-based methods, the extension of kernel methods to multiple kernel learning for feature extraction from data, and the incremental training of multilayer perceptrons to construct deep architectures for enhanced data

  3. Diagnosis of thyroid diseases. The diagnosis value of the various methods of examination

    Energy Technology Data Exchange (ETDEWEB)

    Pfannenstiel, P [Stiftung Deutsche Klinik fuer Diagnostik, Wiesbaden (Germany, F.R.). Fachbereich Nuklearmedizin

    1980-03-01

    The recommendations of the thyroid section of the Deutsche Gesellschaft fuer Endokrinologie take account of practical requirements and serve as a basis for assessing the indications of the various diagnostic methods in view of their value, expenditure, and hazards. Progress in methodology and recent scientific findings have been taken into account as well as economic aspects and the available equipment. In spite of all the possibilities offered by modern laboratory diagnosis, the diagnosis and theory of thyroid diseases should always depend on a special anamnesis and a physical examination of the patient. The measured values must agree with the patient's complaints and with clinical findings. In diagnoses involving several steps, one should always start with simple in-vitro techniques in order to spare the patient stress. Functional diagnosis of thyroid diseases are supplemented by thyroid scintiscanning with short-lived radionuclides and by thyroid cytology. Experience and precise knowledge help to 'save expense and radiation'. Of course, uncertain diagnoses and untypical findings require a more extensive use of diagnostic means than diagnosis that are more or less clinically proved.

  4. Diagnosis of toxic alcohols: limitations of present methods.

    Science.gov (United States)

    Kraut, Jeffrey A

    2015-01-01

    Methanol, ethylene glycol, diethylene glycol, and propylene glycol intoxications are associated with cellular dysfunction and an increased risk of death. Adverse effects can develop quickly; thus, there is a need for methods for rapidly detecting their presence. To examine the value and limitations of present methods to diagnose patients with possible toxic alcohol exposure. I searched MEDLINE for articles published between 1969 and 2014 using the terms: toxic alcohols, serum osmolality, serum osmol gap, serum anion gap, metabolic acidosis, methanol, ethylene glycol, diethylene glycol, propylene glycol, and fomepizole. Each article was reviewed for additional references. The diagnosis of toxic alcohol exposure is often made on the basis of this history and physical findings along with an increase in the serum osmol and anion gaps. However, an increase in the osmol and/or anion gaps is not always present. Definitive detection in blood requires gas or liquid chromatography, laborious and expensive procedures which are not always available. Newer methods including a qualitative colorimetric test for detection of all alcohols or enzymatic tests for a specific alcohol might allow for more rapid diagnosis. Exposure to toxic alcohols is associated with cellular dysfunction and increased risk of death. Treatment, if initiated early, can markedly improve outcome, but present methods of diagnosis including changes in serum osmol and anion gap, and use of gas or liquid chromatography have important limitations. Development of more rapid and effective tests for detection of these intoxications is essential for optimal care of patients.

  5. Maxillary sinusitis - a comparative study of different imaging diagnosis methods

    International Nuclear Information System (INIS)

    Hueb, Marcelo Miguel; Borges, Fabiano de Almeida; Pulcinelli, Emilte; Souza, Wandir Ferreira; Borges, Luiz Marcondes

    1999-01-01

    We conducted prospective study comparing different methods (plain X-rays, computed tomography and ultrasonography mode-A) for the initial diagnosis of maxillary sinusitis. Twenty patients (40 maxillary sinuses) with a clinical history suggestive of sinusitis included in this study. The results were classified as abnormal or normal, using computed tomography as gold standard. The sensitivity for ultrasonography and plain X-rays was 84.6% and 69.2%, respectively. The specificity of both methods was 92.6%. This study suggests that ultrasonography can be used as a good follow-up method for patients with maxillary. sinusitis. (author)

  6. A qualitative diagnosis method for a continuous process monitor system

    International Nuclear Information System (INIS)

    Lucas, B.; Evrard, J.M.; Lorre, J.P.

    1993-01-01

    SEXTANT, an expert system for the analysis of transients, was built initially to study physical transients in nuclear reactors. It combines several knowledge bases concerning measurements, models and qualitative behavior of the plant with a generate-and-test mechanism and a set of numerical models of the physical process. The integration of an improved diagnosis method using a mixed model in SEXTANT in order to take into account the existence and the reliability of only a few number of sensors, the knowledge on failure and the possibility of non anticipated failures, is presented. This diagnosis method is based on two complementary qualitative models of the process and a methodology to build these models from a system description. 8 figs., 17 refs

  7. Thermal Efficiency Degradation Diagnosis Method Using Regression Model

    International Nuclear Information System (INIS)

    Jee, Chang Hyun; Heo, Gyun Young; Jang, Seok Won; Lee, In Cheol

    2011-01-01

    This paper proposes an idea for thermal efficiency degradation diagnosis in turbine cycles, which is based on turbine cycle simulation under abnormal conditions and a linear regression model. The correlation between the inputs for representing degradation conditions (normally unmeasured but intrinsic states) and the simulation outputs (normally measured but superficial states) was analyzed with the linear regression model. The regression models can inversely response an associated intrinsic state for a superficial state observed from a power plant. The diagnosis method proposed herein is classified into three processes, 1) simulations for degradation conditions to get measured states (referred as what-if method), 2) development of the linear model correlating intrinsic and superficial states, and 3) determination of an intrinsic state using the superficial states of current plant and the linear regression model (referred as inverse what-if method). The what-if method is to generate the outputs for the inputs including various root causes and/or boundary conditions whereas the inverse what-if method is the process of calculating the inverse matrix with the given superficial states, that is, component degradation modes. The method suggested in this paper was validated using the turbine cycle model for an operating power plant

  8. Isotopic methods or immuno diagnosis: The Radioimmunoassay and immunoradiometric assay

    International Nuclear Information System (INIS)

    Caso, R.

    1997-01-01

    This work offers an explanation about the more used isotopic techniques for immuno diagnosis: the radioimmunoassay (RIA) and immunoradiometric assay (IRMA). It describes the basic principles of these assays, the antigen-antibody reaction, the radioiodination methods with I-125 for antigens and antibodies, the purification and characterization of labelled compounds. On the order hand they present work gives a review of the methods for separate the bound and free fractions. At the end it offers the principles of the quality control of immunoassay and the future lines of research in the field of RIA and IRMA

  9. An evidential sensor fusion method in fault diagnosis

    Directory of Open Access Journals (Sweden)

    Wen Jiang

    2016-03-01

    Full Text Available Dempster–Shafer evidence theory is widely used in information fusion. However, it may lead to an unreasonable result when dealing with high conflict evidence. In order to solve this problem, we put forward a new method based on the credibility of evidence. First, a novel belief entropy, Deng entropy, is applied to measure the information volume of the evidence and then the discounting coefficients of each evidence are obtained. Finally, weighted averaging the evidence in the system, the Dempster combination rule was used to realize information fusion. A weighted averaging combination role is presented for multi-sensor data fusion in fault diagnosis. It seems more reasonable than before using the new belief function to determine the weight. A numerical example is given to illustrate that the proposed rule is more effective to perform fault diagnosis than classical evidence theory in fusing multi-symptom domains.

  10. Noise diagnosis - a method for early detection of failures in a nuclear plant

    International Nuclear Information System (INIS)

    Brinckmann, H.F.

    1981-01-01

    Noise diagnosis constitutes one method for early detection of plant failures. The method is based on the fact that nearly all undesired processes in a nuclear power plant make a measurable contribution to the noise portion of signals. Well-known examples of undesired processes in pressurized water reactors include core-barrel movement, the vibration of control elements, the appearance of loose parts in the coolant flow, and the process of coolant boiling. Each of these processes has been implicated in past nuclear plant failures. In the German Democratic Republic (GDR) P. Liewers and his colleagues have introduced noise analysis systems into the primary circuit of WWER-440 pressurized water reactors (PWR). The most progressive version (RAS-II) has become a prototype for research and routine investigations. This system is described. (author)

  11. Biotechnological Methods for Precise Diagnosis of Methicillin Resistance in Staphylococci

    Directory of Open Access Journals (Sweden)

    Aija Zilevica

    2005-04-01

    Full Text Available Antimicrobial resistance is one of the most urgent problems in medicine nowadays. The purpose of the study was to investigate the microorganisms resistant to first-line antimicrobials, including gram-positive cocci, particularly the methicillin-resistant Staphylococcus aureus and coagulase-negative Staphylococci, the major agents of nosocomial infections. Owing to the multi-resistance of these agents, precise diagnosis of the methicillin resistance of Staphylococci is of greatest clinical importance. It is not enough to use only conventional microbiological diagnostic methods. Biotechnological methods should be also involved. In our studies, the following methicillin resistance identification methods were used: the disk diffusion method, detection of the mecA gene by PCR, E-test and Slidex MRSA test. For molecular typing, PFGL, RAPD tests and detection of the coa gene were used. All the MRS strains were multiresistant to antibacterials. No vancomycine resistance was registered.

  12. [Laboratory diagnosis of genital herpes--direct immunofluorescence method].

    Science.gov (United States)

    Majewska, Anna; Romejko-Wolniewicz, Ewa; Zareba-Szczudlik, Julia; Kilijańczyk, Marek; Gajewska, Małgorzata; Młynarczyk, Grazyna

    2013-07-01

    Aim of the study was to determine clinical usefulness of direct immunofluorescence method in the laboratory diagnosis of genital herpes in women. Overall 187 anogenital swabs were collected from 120 women. Using a dacron-tipped applicator 83 swabs were collected from women suspected of genital herpes and 104 from patients with no signs of genital infection. All samples were tested using cell culture (Vero cell line) and then direct immunofluorescence method (DIF) for the identification of antigens of herpes simplex viruses: HSV-1 and HSV-2. Characteristic cytopathic effect (CPE), indicative of alphaherpesvirus infection, was observed in 43.4% of cultures with clinical specimens collected from women with suspected genital herpes and in 29.8% of cultures of clinical specimens taken from patients with no clinical symptoms of genital herpes. Herpes simplex viruses were determined in 73 samples by direct immunofluorescence method after amplification of the virus in cell culture. The DIF test confirmed the diagnosis based on the microscopic CPE observation in 85%. In 15% of samples (taken from pregnant women without clinical signs of infection) we reported positive immunofluorescence in the absence of CPE. The frequency of antigen detection was statistically significantly higher in samples that were positive by culture study (chi-square test with Yates's correction, p genital herpes in swabs taken from the vestibule of the vagina and the vulva. However, there was no statistically significant difference in the frequency of detection of Herpes Simplex Virus antigens in specimens from different parts of the genital tract in both groups of women (chi-square test, p > 0.05). In our study HHV-1 was the main causative agent of genital herpes. The growing worldwide prevalence of genital herpes, challenges with the clinical diagnosis, and availability of effective antiviral therapy are the main reasons for a growing interest in rapid, proper laboratory diagnosis of infected

  13. Research Progress on Diagnosis Methods for Fungal Infection

    Directory of Open Access Journals (Sweden)

    Feng Hua

    2015-12-01

    Full Text Available In recent years, owing to abuse of antibiotics, extensive use of antitumor drugs and immunosuppressive agents and other reasons, an increasing number of people suffered from fungal infection. In this situation, researchers proposed new diagnosis methods, such as G test, galactomannan (GM test, and polymerase chain reaction (PCR. G test is simple, quick, and highly sensitive and can detect multiple fungi; however, it cannot distinguish fungal types and may result in false positive and false negative results. GM test is less time consuming and feature highly positive detection rates but can simply be used in inspection of invasive aspergillosis. However, optimal positive critical values of GM test remain controversial. PCR is currently one of the fastest methods but is not formally used in clinical practice because of its lack of standardized operation and evaluation criteria. This study reviews the above three methods with the aim of discovering and summarizing their advantages and disadvantages to facilitate research and development of new diagnosis methods.

  14. A Novel Method for Bacterial UTI Diagnosis Using Raman Spectroscopy

    Directory of Open Access Journals (Sweden)

    Evdokia Kastanos

    2012-01-01

    Full Text Available The current state of the art on bacterial classification using Raman and Surface Enhanced Raman Spectroscopy (SERS for the purpose of developing a rapid and more accurate method for urinary tract infection (UTI diagnosis is presented. SERS, an enhanced version of Raman offering much increased sensitivity, provides complex biochemical information which, in conjunction with advanced analysis and classification techniques, can become a valuable diagnostic tool. The variety of metal substrates used for SERS, including silver and gold colloids, as well as nanostructured metal surfaces, is reviewed. The challenges in preprocessing noisy and complicated spectra and the various methods used for feature creation as well as a novel method using spectral band ratios are described. The various unsupervised and supervised classification methods commonly used for SERS spectra of bacteria are evaluated. Current research on transforming SERS into a valuable clinical tool for the diagnosis of UTIs is presented. Specifically, the classification of bacterial spectra (a as positive or negative for an infection, (b as belonging to a particular species of bacteria, and (c as sensitive or resistant to an antibiotic are described. This work can lead to the development of novel technology with extremely important benefits for public health.

  15. Diagnosis of condensation-induced waterhammer: Methods and background

    International Nuclear Information System (INIS)

    Izenson, M.G.; Rothe, P.H.; Wallis, G.B.

    1988-10-01

    This guidebook provides reference material and diagnostic procedures concerning condensation-induced waterhammer in nuclear power plants. Condensation-induced waterhammer is the most damaging form of waterhammer and its diagnosis is complicated by the complex nature of the underlying phenomena. In Volume 1, the guidebook groups condensation-induced waterhammers into five event classes which have similar phenomena and levels of damage. Diagnostic guidelines focus on locating the event center where condensation and slug acceleration take place. Diagnosis is described in three stages: an initial assessment, detailed evaluation and final confirmation. Graphical scoping analyses are provided to evaluate whether an event from one of the event classes could have occurred at the event center. Examples are provided for each type of waterhammer. Special instructions are provided for walking down damaged piping and evaluating damage due to waterhammer. To illustrate the diagnostic methods and document past experience, six case studies have been compiled in Volume 2. These case studies, based on actual condensation-induced waterhammer events at nuclear plants, present detailed data and work through the event diagnosis using the tools introduced in the first volume. 65 figs., 8 tabs

  16. Contemporary constellations of nuclear medical methods for diagnosis of hyperparathyroidism

    International Nuclear Information System (INIS)

    Radeva, M.; Doseva, V.

    2000-01-01

    There are selected contemporary methods for diagnosis of the primary and the secondary hyperparathyroidism. The serum concentration of the parathormone were determined by radioimmunoassay method for 178 patients with different stage of progress hyperparathyroidism. In 26 patients was performed scintigraphy by SPECT gamma camera for visualization of eventual parathyroid adenoma. The double isotope method namely 123 I for visualization thyroid gland and 99m Tc-MIBI for study parathyroid adenomas ware put into practice for the first time in Bulgaria. In consequence of the study in the part of the patients with primary and secondary hyperparathyroidism were visualized adenomas and determined the localization relationship of thyroid gland. The results were compared with echography and with serum level of Ca and P in the patients with primary hyperparathyroidism. (authors)

  17. Non-immunologic methods of diagnosis of babesiosis

    Directory of Open Access Journals (Sweden)

    G. Wagner

    1992-01-01

    Full Text Available The diagnosis of tick-borne diseases such as babesiosis still depends on observing the parasite in the infected erythrocyte. Microscopic observation is tedious and often problematic in both early and carrier infections. Better diagnostic methods are needed to prevent clinical disease, especially when susceptible cattle are being moved into disease enzootic areas. This study evaluates two techniques for early diagnosis of Babesia bovis infections in cattle, DNA probes specific for the organism and fluorescent probes specific nucleic acid. The radioisotopically labeled DNA probes are used in slot blot hybridizations whith lysed blood samples, not purified DNA. Thusfar, the probe is specific for B. bovis and can detect as few as 1000 B. bovis parasites in 10µl of blood. The specificity of the fluorescent probe depends on the characteristic morphology of the babesia in whole blood samples, as determined microscopically. The fluorescent probe detects as afew as 10,000 B. bovis parasites in 10*l as blood. The application of each method for alboratory and field use is discussed.

  18. Advanced soft computing diagnosis method for tumour grading.

    Science.gov (United States)

    Papageorgiou, E I; Spyridonos, P P; Stylios, C D; Ravazoula, P; Groumpos, P P; Nikiforidis, G N

    2006-01-01

    To develop an advanced diagnostic method for urinary bladder tumour grading. A novel soft computing modelling methodology based on the augmentation of fuzzy cognitive maps (FCMs) with the unsupervised active Hebbian learning (AHL) algorithm is applied. One hundred and twenty-eight cases of urinary bladder cancer were retrieved from the archives of the Department of Histopathology, University Hospital of Patras, Greece. All tumours had been characterized according to the classical World Health Organization (WHO) grading system. To design the FCM model for tumour grading, three experts histopathologists defined the main histopathological features (concepts) and their impact on grade characterization. The resulted FCM model consisted of nine concepts. Eight concepts represented the main histopathological features for tumour grading. The ninth concept represented the tumour grade. To increase the classification ability of the FCM model, the AHL algorithm was applied to adjust the weights of the FCM. The proposed FCM grading model achieved a classification accuracy of 72.5%, 74.42% and 95.55% for tumours of grades I, II and III, respectively. An advanced computerized method to support tumour grade diagnosis decision was proposed and developed. The novelty of the method is based on employing the soft computing method of FCMs to represent specialized knowledge on histopathology and on augmenting FCMs ability using an unsupervised learning algorithm, the AHL. The proposed method performs with reasonably high accuracy compared to other existing methods and at the same time meets the physicians' requirements for transparency and explicability.

  19. Constitutional Conservatism

    Science.gov (United States)

    Berkowitz, Peter

    2009-01-01

    After their dismal performance in election 2008, conservatives are taking stock. As they examine the causes that have driven them into the political wilderness and as they explore paths out, they should also take heart. After all, election 2008 shows that America's constitutional order is working as designed. Indeed, while sorting out their errors…

  20. Fault Diagnosis of Batch Reactor Using Machine Learning Methods

    Directory of Open Access Journals (Sweden)

    Sujatha Subramanian

    2014-01-01

    Full Text Available Fault diagnosis of a batch reactor gives the early detection of fault and minimizes the risk of thermal runaway. It provides superior performance and helps to improve safety and consistency. It has become more vital in this technical era. In this paper, support vector machine (SVM is used to estimate the heat release (Qr of the batch reactor both normal and faulty conditions. The signature of the residual, which is obtained from the difference between nominal and estimated faulty Qr values, characterizes the different natures of faults occurring in the batch reactor. Appropriate statistical and geometric features are extracted from the residual signature and the total numbers of features are reduced using SVM attribute selection filter and principle component analysis (PCA techniques. artificial neural network (ANN classifiers like multilayer perceptron (MLP, radial basis function (RBF, and Bayes net are used to classify the different types of faults from the reduced features. It is observed from the result of the comparative study that the proposed method for fault diagnosis with limited number of features extracted from only one estimated parameter (Qr shows that it is more efficient and fast for diagnosing the typical faults.

  1. Differential diagnosis of neurodegenerative dementias with nuclear medicine methods

    International Nuclear Information System (INIS)

    Kluge, R.

    2015-01-01

    Full text: Neurodegenerative dementias (NDD) are characterized by insidious onset and gradual progression of cognitive dysfunction, initially relatively focal with respect to cognitive domains and brain regions involved. Nuclear medicine techniques help to clarify differential diagnoses of syndromes such as Alzheimer’s disease (AD), dementia with Lewy bodies (DlB), posterior cortical atrophy (PCA), logopenic primary progressive aphasia (PPA), agrammatic PPA, semantic dementia (SD), behavioral variant frontotemporal dementia (bvFTD) and progressive supranuclear palsy syndrome (PSPS). The process of pathologic changes in the brain may start decades before first clinical symptoms become evident. An early diagnosis already in the pre-clinical phase of the diseases will be of immense importance when expected effective therapeutic options have been introduced. NDDs are histopathologically characterized by accumulation of pathological proteins in the brain like beta amyloid or protein tau. While radiotracers for labeling of protein tau are in preclinical evaluation, different radiotracers labeling amyloid plaques ([11C]PIB, [18F]Florbetapir (Amyvid, Fa. EliLilly), [18F]Florbetaben (Neuraceq, Fa. Piramal), [18F]Flutemetamol (vVzamyl, Fa. Ge) have already been established in clinical use during the last years. In AD these tracers are intensively accumulated in the whole cortical brain. Even an early disease can be excluded in case of a negative amyloid PET. The method is, however, not highly specific since amyloid plaques may also be present in DlB (70 – 80%), FTD (30%) orlogopenicPPA (100%). Neuronal dysfunction goes along with decreased glucose consumption. Different diseases are characterized by different topographical zones of reduced [18F]FDG uptake. In AD the posterior cingular, temporopariatal and (later) frontal cortex are affected, in DlB the pattern is similar, including the occipital cortex, in FTD the frontal cortex is affected, in nonfluent PPA the

  2. Toxoplasmosis: The value of molecular methods in diagnosis compared to conventional methods

    Directory of Open Access Journals (Sweden)

    Zineb Tlamçani

    2013-06-01

    Full Text Available Toxoplasmosis is a parasitic infection due to Toxoplasma gondii an obligate intracellular protozoan parasite. It is considerateone of the most common parasite worldwide. The contamination of the parasite is generally occurred via consumptionof infected food or water or, undercooked contaminated meat. Toxoplasma gondii infection may lead to seriousillness when the organism is contracted while pregnancy or when it is reactivated in immune-suppressed persons.Diagnosis of toxoplasmosis in humans is elaborated using various techniques such as detection of anti-Toxoplasmaantibodies, mouse inoculation, histological revelation of tachyzoites in tissue sections or smears of body fluid, but thedetection of Toxoplasma gondii DNA by molecular methods has revolutionized prenatal diagnosis of congenital toxoplasmosisand in immunocompromised patients. In this paper we will discuss the parasite and different methods ofdiagnosis including the usefulness of molecular methods. J Microbiol Infect Dis 2013; 3(2: 93-99Key words: Toxoplamosis, Toxoplasma gondii, diagnosis

  3. Expert System Diagnosis of Cataract Eyes Using Fuzzy Mamdani Method

    Science.gov (United States)

    Santosa, I.; Romla, L.; Herawati, S.

    2018-01-01

    Cataracts are eye diseases characterized by cloudy or opacity of the lens of the eye by changing the colour of black into grey-white which slowly continues to grow and develop without feeling pain and pain that can cause blindness in human vision. Therefore, researchers make an expert system of cataract eye disease diagnosis by using Fuzzy Mamdani and how to care. The fuzzy method can convert the crisp value to linguistic value by fuzzification and includes in the rule. So this system produces an application program that can help the public in knowing cataract eye disease and how to care based on the symptoms suffered. From the results of the design implementation and testing of expert system applications to diagnose eye disease cataracts, it can be concluded that from a trial of 50 cases of data, obtained test results accuracy between system predictions with expert predictions obtained a value of 78% truth.

  4. An improved microculture method for diagnosis of cutaneous leishmaniasis.

    Science.gov (United States)

    Pagheh, Abdolsattar; Fakhar, Mahdi; Mesgarian, Fatemeh; Gholami, Shirzad; Ahmadpour, Ehsan

    2014-12-01

    This study evaluated the performance of three diagnostic methods for cutaneous leishmaniasis (CL). Patients who came to the Health Center Laboratory of Gonbad-e-Qabus in Golestan Province, Iran, were enrolled in the study. Skin scraping smear, improved microculture (IMC) and polymerase chain reaction (PCR) were performed. A total of 303 subjects were recruited, among whom 273 subjects fulfilled the criteria for CL. Sensitivity and specificity were 88.8 % (95 % CI = 84.2-92.2 %) and 100.0 % for smears, 98.4 % (95 % CI = 96.1-99.1 %) and 100.0 % for IMC, both of them 100.0 % for PCR. Although, PCR was relatively more sensitive than the IMC, the high correlation (agreement = 96 %, Kappa = 0.82) between IMC and PCR along with the advantages of simplicity, rapidity, adequate sensitivity and as a needle free method, offers the IMC as a valuable alternative diagnostic method for PCR in diagnosis of CL.

  5. Application of forwardchaining method to diagnosis of onion plant diseases

    Science.gov (United States)

    Sitanggang, Delima; Siregar, Saut D.; Situmeang, Suryani M. F.; Indra, Evta; Sagala, Ayu R.; Sihombing, Oloan; Nababan, Marlince; Pasaribu, Hendra; Damanik, Rudolf R.; Turnip, Mardi; Saragih, Rijois I. E.

    2018-04-01

    Red Onion is a tuber plant that is widely used by the people of Indonesia, both as herbs and herbal medicines. Onion farmers have limitations in identifying diseases that attack their crops.This disease can cause crop failure against the onion.This design begins with the creation of a knowledge base up to input-output design with forward chaining method. The results of this design can assist farmers in identifying their plant diseases. Based on diagnostic results of several methods that have been done testing can diagnose diseases contained in onion plants. With symptoms data that has been determined by the expert with the value of each symptom is different. As for the symptoms that have been determined that the leaves contain patches with a value of 0.3, White leaf spots value 0.4, Leaf spots form a purple zone if it is severe 0.5, Leaf tip of 0.2, Tubers rot 0.4. Based on the above diagnostic results then get the value of diagnosis 67% forward chaining with trotol disease type, Purple spotting.

  6. A sensitive new microculture method for diagnosis of cutaneous leishmaniasis.

    Science.gov (United States)

    Allahverdiyev, Adil M; Uzun, Soner; Bagirova, Malahat; Durdu, Murat; Memisoglu, Hamdi R

    2004-03-01

    A sensitive microcapillary culture method (MCM) was developed for rapid diagnosis of cutaneous leishmaniasis (CL). The MCM is superior to the traditional culture method (TCM) as determined by the smaller inoculum size, the higher sensitivity for detection of promastigotes, and the more rapid time for emergence of promastigotes. With lesion amastigote loads from grade III to 0, the positive rates and the periods for promastigote emergence were 3-4-fold higher and faster with the MCM than with the TCM, e.g., 83-97% positive in 4-7 days versus 20-40% positive in 15-30 days (P = 0.0001). The higher Pco(2) and lower Po(2) and pH presumably encourage a rapid amastigote-to-promastigote differentiation and/or the survival or growth of the latter. This MCM has the advantage of simplicity, and may be suitable for diagnostic use and for parasite retrieval in many other endemic sites where parasites are known to be difficult to grow.

  7. Equivalent circuit method research of resonant magnetoelectric characteristic in magnetoelectric laminate composites using nonlinear magnetostrictive constitutive model

    International Nuclear Information System (INIS)

    Zhou, Hao-Miao; Li, Chao; Xuan, Li-Ming; Zhao, Ji-Xiang; Wei, Jing

    2011-01-01

    This paper analyzes the magnetoelectric (ME) response around the resonance frequency in the magnetostrictive/piezoelectric/magnetostrictive (MPM) magnetoelectric laminate composites. Following the equivalent circuit method and considering the mechanical loss, we select the nonlinear magnetostrictive constitutive model to present a novel explicit nonlinear expression for the resonant magnetoelectric (ME) coefficient of the magnetoelectric laminate composites. Compared with the experimental results, the predicted resonant ME coefficient of the explicit expression shows a good agreement both qualitatively and quantitatively. Also, when the electromechanical coupling factor of the piezoelectric material, k 31 p , is small, this explicit expression can be reduced to the existing model. On this basis, this paper considers and predicts the magnetoelectric conversion characteristics of the magnetoelectric laminate composites, calculates and analyzes the influences of the thickness ratio of magnetostrictive layer and piezoelectric material, bias magnetic field, and saturation magnetostrictive coefficient on the resonant ME coefficient. This research can provide a theoretical basis for the preparation of magnetoelectric devices with good magnetoelectric conversion characteristics, such as magnetoelectric sensors, energy harvesting transducers, microwave devices etc

  8. APPLICATION IMMUNOHISTOCHEMICALLY RESEARCH METHODS IN THE DIAGNOSIS OF PROSTATE CANCER

    Directory of Open Access Journals (Sweden)

    S. A. Pulbere

    2017-01-01

    Full Text Available Introduction. The actual problem of modern urology remains differential diagnostics of various diseases of the prostate gland. The purpose of the study. Increasing the effectiveness of differential diagnosis of diseases of the prostate. Materials and methods. In the biopsy specimens of patients with benign prostatic hyperplasia (BPH and prostate cancer (PCa, an immunohistochemical study of the production of the Ki-67 proliferation marker, matrix metalloproteinase-9, the matrix metalloproteinase inhibitor TIMP-1, and the distribution of collagen type IV was performed. Results. A moderate positive correlation was found between Gleason gradation and the cell proliferation index for Ki 67 (rs = 0.674 and a moderate negative correlation of Gleason gradation with the level of production of matrix metalloproteinase-9 (rs = -0.660. A weak significant negative correlation was established between the level of proliferative cell activity and the production of  MMP-9 tumor cells (rs = -0.369. A significant decrease in the level of MMP-9 and TIMP-1 in adenocarcinoma of different grades was revealed. The invasive properties of tumor cells, expressed in the destruction of collagen of the IV type of the basal membrane and connective tissue prostatic stroma, are mediated by the imbalance between MMP-9 and the protein blocking this enzyme - TIMP-1, whose production decreases in adenocarcinomas of different grades compared with BPH. Conclusions: 1. BPH is characterized by high production of MMP-9 type, which destroys the collagen of the basal membranes and stroma, the proteolytic action of which is blocked by the high content of TIMP-1.

  9. THE COMBINATION METHOD FOR DEPENDENT EVIDENCE AND ITS APPLICATION FOR SIMULTANEOUS FAULTS DIAGNOSIS

    OpenAIRE

    HAI-NA JIANG; XIAO-BIN XU; CHENG-LIN WEN

    2015-01-01

    This paper provides a method based on Dezert-Smarandache Theory (DSmT) for simultaneous faults diagnosis when evidence is dependent. Firstly, according to the characteristics of simultaneous faults, a frame of discernment is given for both single fault and simultaneous faults diagnosis, the DSmT combination rule applicable to simultaneous faults diagnosis is introduced.

  10. A Mixed Methods Study of Barriers to Formal Diagnosis of Autism Spectrum Disorder in Adults

    Science.gov (United States)

    Lewis, Laura Foran

    2017-01-01

    Delayed diagnosis of autism spectrum disorder (ASD) into adulthood is common, and self-diagnosis is a growing phenomenon. This mixed methods study aimed to explore barriers to formal diagnosis of ASD in adults. In a qualitative strand, secondary analysis of data on the experiences of 114 individuals who were self-diagnosed or formally diagnosed…

  11. β-characterization by irreversibility analysis: A thermoeconomic diagnosis method

    International Nuclear Information System (INIS)

    Zaleta-Aguilar, Alejandro; Olivares-Arriaga, Abraham; Cano-Andrade, Sergio; Rodriguez-Alejandro, David A.

    2016-01-01

    This paper presents a reconciliation methodology for the diagnosis of energy systems. The methodology is based on the characterization of irreversibilities in the components of an energy system. These irreversibilities can be attributed to malfunctions or dysfunctions. The characterization of irreversibilities as presented here makes possible to reconcile the Actual Operating Condition (AOC) versus the Reference Operating Condition (ROC) of the energy system in a real-time manner. The diagnosis methodology introduces a parameter β, which represents the total exergy or useful work of a component in terms of its inlet and output streams at either design (full-load) or off-design (partial-load) conditions. The methodology is applied to the diagnosis of an actual Natural Gas Combined Cycle (NGCC) power plant. Data for the model is obtained directly from the plant by monitoring its performance at every time; thus, a real-time thermodynamic diagnosis for the system is obtained. Results show that the methodology presented here is able to detect and quantify the deviations on the performance of the NGCC power plant during its real-time operation. Based on the detection and quantification of these deviations, the user is able to make recommendations to schedule maintenance on the components where the irreversibilities are present. - Highlights: • A new methodology for thermoeconomic diagnosis of energy systems is presented. • A parameter β is defined for characterization of the components of an energy system. • The β characterization methodology is tested in a real 420 MW NGCC power plant. • Results show that the complexity of a diagnosis analysis is reduced substantially.

  12. Methods for Improving the Diagnosis of a Brugada ECG Pattern.

    Science.gov (United States)

    Gottschalk, Byron H; Garcia-Niebla, Javier; Anselm, Daniel D; Glover, Benedict; Baranchuk, Adrian

    2016-03-01

    Brugada syndrome (BrS) is an inherited channelopathy that predisposes individuals to malignant arrhythmias and can lead to sudden cardiac death. The condition is characterized by two electrocardiography (ECG) patterns: the type-1 or "coved" ECG and the type-2 or "saddleback" ECG. Although the type-1 Brugada ECG pattern is diagnostic for the condition, the type-2 Brugada ECG pattern requires differential diagnosis from conditions that produce a similar morphology. In this article, we present a case that is suspicious but not diagnostic for BrS and discuss the application of ECG methodologies for increasing or decreasing suspicion for a diagnosis of BrS. © 2015 Wiley Periodicals, Inc.

  13. Diagnosis of Cognitive Errors by Statistical Pattern Recognition Methods.

    Science.gov (United States)

    Tatsuoka, Kikumi K.; Tatsuoka, Maurice M.

    The rule space model permits measurement of cognitive skill acquisition, diagnosis of cognitive errors, and detection of the strengths and weaknesses of knowledge possessed by individuals. Two ways to classify an individual into his or her most plausible latent state of knowledge include: (1) hypothesis testing--Bayes' decision rules for minimum…

  14. Nuclear power plant pressurizer fault diagnosis using fuzzy signed-digraph and spurious faults elimination methods

    International Nuclear Information System (INIS)

    Park, Joo Hyun

    1994-02-01

    In this work, the Fuzzy Signed Digraph(FSD) method which has been researched for the fault diagnosis of industrial process plant systems is improved and applied to the fault diagnosis of the Kori-2 nuclear power plant pressurizer. A method for spurious faults elimination is also suggested and applied to the fault diagnosis. By using these methods, we could diagnose the multi-faults of the pressurizer and could also eliminate the spurious faults of the pressurizer caused by other subsystems. Besides the multi-fault diagnosis and system-wide diagnosis capabilities, the proposed method has many merits such as real-time diagnosis capability, independency of fault pattern, direct use of sensor values, and transparency of the fault propagation to the operators

  15. Nuclear power plant pressurizer fault diagnosis using fuzzy signed-digraph and spurious faults elimination methods

    International Nuclear Information System (INIS)

    Park, Joo Hyun; Seong, Poong Hyun

    1994-01-01

    In this work, the Fuzzy Signed Digraph (FSD) method which has been researched for the fault diagnosis of industrial process plant systems is improved and applied to the fault diagnosis of the Kori-2 nuclear power plant pressurizer. A method for spurious faults elimination is also suggested and applied to the fault diagnosis. By using these methods, we could diagnose the multi-faults of the pressurizer and could also eliminate the spurious faults of the pressurizer caused by other subsystems. Besides the multi-fault diagnosis and system-wide diagnosis capabilities, the proposed method has many merits such as real-time diagnosis capability, independency of fault pattern, direct use of sensor values, and transparency of the fault propagation to the operators. (Author)

  16. Constitutive analysis to predict the hot deformation behavior of 34CrMo4 steel with an optimum solution method for stress multiplier

    International Nuclear Information System (INIS)

    Xu, Wujiao; Zou, Mingping; Zhang, Lei

    2014-01-01

    The hot deformation behaviors of steel 34CrMo4 is investigated by hot compression test with the temperature range of 1073–1373 K and the strain rate range of 0.01–10 s −1 . The flow behaviors of 34CrMo4 steel were characterized based on the true stress–true strain curves. The hyperbolic sine law in Arrhenius type is adopted in the constitutive modeling for 34CrMo4. Solving algorithm of the stress multiplier α in hyperbolic sine law is a key factor to guarantee the constitutive model accuracy. How to solve the stress multiplier α is investigated and an optimum solution method for α is proposed. Meanwhile, the influence of strain is incorporated in constitutive analysis by considering the effect of strain on material constants α, n, Q and A. With the optimum solution method for stress multiplier α proposed, the stress prediction is satisfactory with the higher correlation coefficient, R = 0.988 and the lower average absolute relative error, AARE = 3.44% for the entire strain rate-temperature domain. The optimum solution method for stress multiplier α can also be applied for other materials to predict the flow behavior more accurately. - Highlights: • Isothermal compression tests were conducted to study the flow behavior of 34CrMo4. • The influence of strain is incorporated in constitutive model. • An optimum solution method for stress multiplier α is proposed

  17. Handling Diagnosis of Schizophrenia by a Hybrid Method

    Directory of Open Access Journals (Sweden)

    Luciano Comin Nunes

    2015-01-01

    Full Text Available Psychotics disorders, most commonly known as schizophrenia, have incapacitated professionals in different sectors of activities. Those disorders have caused damage in a microlevel to the individual and his/her family and in a macrolevel to the economic and production system of the country. The lack of early and sometimes very late diagnosis has provided reactive measures, when the professional is already showing psychological signs of incapacity to work. This study aims to help the early diagnosis of psychotics’ disorders with a hybrid proposal of an expert system that is integrated to structured methodologies in decision support (multicriteria decision analysis: MCDA and knowledge structured representations into production rules and probabilities (artificial intelligence: AI.

  18. Inference method using bayesian network for diagnosis of pulmonary nodules

    International Nuclear Information System (INIS)

    Kawagishi, Masami; Iizuka, Yoshio; Yamamoto, Hiroyuki; Yakami, Masahiro; Kubo, Takeshi; Fujimoto, Koji; Togashi, Kaori

    2010-01-01

    This report describes the improvements of a naive Bayes model that infers the diagnosis of pulmonary nodules in chest CT images based on the findings obtained when a radiologist interprets the CT images. We have previously introduced an inference model using a naive Bayes classifier and have reported its clinical value based on evaluation using clinical data. In the present report, we introduce the following improvements to the original inference model: the selection of findings based on correlations and the generation of a model using only these findings, and the introduction of classifiers that integrate several simple classifiers each of which is specialized for specific diagnosis. These improvements were found to increase the inference accuracy by 10.4% (p<.01) as compared to the original model in 100 cases (222 nodules) based on leave-one-out evaluation. (author)

  19. Critical analysis of imaging methods for the detection and diagnosis of breast cancer

    International Nuclear Information System (INIS)

    Mendonca, Maria Helena Siqueira

    1999-01-01

    Breast cancer is a significant health problem. Early diagnosis of the disease is mandatory to increase the effectiveness of the treatment, to augment the chances of cure and to permit conservative surgery. The use of imaging methods is essential in the early diagnosis of the disease. Imaging methods advantages and disadvantages, use and limitations, specificity and sensitivity are presented and discussed. (author)

  20. Fault diagnosis method for nuclear power plants based on neural networks and voting fusion

    International Nuclear Information System (INIS)

    Zhou Gang; Ge Shengqi; Yang Li

    2010-01-01

    A new fault diagnosis method based on multiple neural networks (ANNs) and voting fusion for nuclear power plants (NPPs) was proposed in view of the shortcoming of single neural network fault diagnosis method. In this method, multiple neural networks that the types of neural networks were different were trained for the fault diagnosis of NPP. The operation parameters of NPP, which have important affect on the safety of NPP, were selected as the input variable of neural networks. The output of neural networks is fault patterns of NPP. The last results of diagnosis for NPP were obtained by fusing the diagnosing results of different neural networks by voting fusion. The typical operation patterns of NPP were diagnosed to demonstrate the effect of the proposed method. The results show that employing the proposed diagnosing method can improve the precision and reliability of fault diagnosis results of NPPs. (authors)

  1. Aided diagnosis methods of breast cancer based on machine learning

    Science.gov (United States)

    Zhao, Yue; Wang, Nian; Cui, Xiaoyu

    2017-08-01

    In the field of medicine, quickly and accurately determining whether the patient is malignant or benign is the key to treatment. In this paper, K-Nearest Neighbor, Linear Discriminant Analysis, Logistic Regression were applied to predict the classification of thyroid,Her-2,PR,ER,Ki67,metastasis and lymph nodes in breast cancer, in order to recognize the benign and malignant breast tumors and achieve the purpose of aided diagnosis of breast cancer. The results showed that the highest classification accuracy of LDA was 88.56%, while the classification effect of KNN and Logistic Regression were better than that of LDA, the best accuracy reached 96.30%.

  2. Fecal specimens preparation methods for PCR diagnosis of human taeniosis

    Directory of Open Access Journals (Sweden)

    Nunes Cáris Maroni

    2006-01-01

    Full Text Available Sample preparation and DNA extraction protocols for DNA amplification by PCR, which can be applied in human fecal samples for taeniasis diagnosis, are described. DNA extracted from fecal specimens with phenol/chloroform/isoamilic alcohol and DNAzol® reagent had to be first purified to generate fragments of 170 pb and 600 pb by HDP2-PCR. This purification step was not necessary with the use of QIAmp DNA stool mini kit®. Best DNA extraction results were achieved after eggs disruption with glass beads, either with phenol/chloroform/isoamilic alcohol, DNAzol® reagent or QIAmp DNA stool mini kit®.

  3. Research on the Method of Big Data Collecting, Storing and Analyzing of Tongue Diagnosis System

    Science.gov (United States)

    Chen, Xiaowei; Wu, Qingfeng

    2018-03-01

    This paper analyzes the contents of the clinical data of tongue diagnosis of TCM (Traditional Chinese Medicine), and puts forward a method to collect, store and analyze the clinical data of tongue diagnosis. Under the guidance of TCM theory of syndrome differentiation and treatment, this method combines with Hadoop, which is a distributed computing system with strong expansibility, and integrates the functions of analysis and conversion of big data of clinic tongue diagnosis. At the same time, the consistency, scalability and security of big data in tongue diagnosis are realized.

  4. Device and method for traditional chinese medicine diagnosis using radioactive tracer method

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Shanling; Shen, Miaohe

    1997-05-29

    Disclosed is a device and method for traditional chinese medicine diagnosis using radioactive-tracer method. At least two nuclear radiation probes are arranged apart along the channels to detect the changing with time and on space of the intensity of radioactivity of the nuclear radioactive tracer which has been injected into the body in the channel position. The detected signals are amplified by amplifiers, and the outputs of the amplifiers are applied to data processing means which monitor the whole detecting process in real time and analyse and process the detected information about the changing of the intensity of radioactivity with time and on space indicating the operating of vital energy and blood, and obtain state parameters about operating of vital energy and blood in the body which is then output through data output means. (author) figs.

  5. Track Circuit Fault Diagnosis Method based on Least Squares Support Vector

    Science.gov (United States)

    Cao, Yan; Sun, Fengru

    2018-01-01

    In order to improve the troubleshooting efficiency and accuracy of the track circuit, track circuit fault diagnosis method was researched. Firstly, the least squares support vector machine was applied to design the multi-fault classifier of the track circuit, and then the measured track data as training samples was used to verify the feasibility of the methods. Finally, the results based on BP neural network fault diagnosis methods and the methods used in this paper were compared. Results shows that the track fault classifier based on least squares support vector machine can effectively achieve the five track circuit fault diagnosis with less computing time.

  6. Logarithmic Similarity Measure between Interval-Valued Fuzzy Sets and Its Fault Diagnosis Method

    Directory of Open Access Journals (Sweden)

    Zhikang Lu

    2018-02-01

    Full Text Available Fault diagnosis is an important task for the normal operation and maintenance of equipment. In many real situations, the diagnosis data cannot provide deterministic values and are usually imprecise or uncertain. Thus, interval-valued fuzzy sets (IVFSs are very suitable for expressing imprecise or uncertain fault information in real problems. However, existing literature scarcely deals with fault diagnosis problems, such as gasoline engines and steam turbines with IVFSs. However, the similarity measure is one of the important tools in fault diagnoses. Therefore, this paper proposes a new similarity measure of IVFSs based on logarithmic function and its fault diagnosis method for the first time. By the logarithmic similarity measure between the fault knowledge and some diagnosis-testing samples with interval-valued fuzzy information and its relation indices, we can determine the fault type and ranking order of faults corresponding to the relation indices. Then, the misfire fault diagnosis of the gasoline engine and the vibrational fault diagnosis of a turbine are presented to demonstrate the simplicity and effectiveness of the proposed diagnosis method. The fault diagnosis results of gasoline engine and steam turbine show that the proposed diagnosis method not only gives the main fault types of the gasoline engine and steam turbine but also provides useful information for multi-fault analyses and predicting future fault trends. Hence, the logarithmic similarity measure and its fault diagnosis method are main contributions in this study and they provide a useful new way for the fault diagnosis with interval-valued fuzzy information.

  7. Nuclear power plant pressurizer fault diagnosis using fuzzy signed-digraph method

    International Nuclear Information System (INIS)

    Park, Joo Hyun; Seong, Poong Hyun

    2004-01-01

    In this study, The Fuzzy Signed Digraph method which has been researched and applied to the chemical process is improved and applied to the fault diagnosis of the pressurizer in nuclear power plants. The Fuzzy Signed-Digraph (FSD) is the method which applies the fuzzy number to the Signed-Digraph (SDG) method. The current SDG methods have many merits as follows: (1) SDG method can directly use the value of sensors not the alarm to the fault diagnosis. (2) This method can diagnose the fault independent on the pattern. (3) This method can diagnose the faults fastly because the method uses the cause-effect relation instead of the complex control equation among the variables. But, they are not proper to be applied to the diagnosis of the multi-faults and to diagnose faults on real time. It is because the unmeasured nodes in those methods must be connected to each other in order to find out the single fault under the single-fault assumption. These methods need long CPU time and cannot be applied to the multi-faults diagnosis. We propose a method in which the values of the unmeasured nodes are calculated from the relations between the unmeasured nodes and the measured nodes. By using this method, the CPU time for diagnosis can be reduced. This CPU time reduction makes the real-time diagnosis possible. This method can also be applied for the multi-faults diagnosis. This method is applied to the diagnosis of the pressurizer of the nuclear power plant KORI-2 in Korea. (author)

  8. Patient and staff dose optimisation in nuclear medicine diagnosis methods

    International Nuclear Information System (INIS)

    Marta Wasilewska-Radwanska; Katarzyna Natkaniec

    2007-01-01

    Complete test of publication follows. The implementation of the Basic Safety Standards (BSS) Directive 96/29 on the protection of workers and general population against the danger arising from ionising radiation and the Directive 97/43 on health protection of individuals against dangers of ionising radiation in relation to medical exposure, known as the Medical Exposure Directive (MED), they started in Poland some years ago with the Polish Atomic Law and executive orders published by the Polish Government and Polish Health Minister. Poland's Government has applied for several years transitory period to complete implementation of the Directive 97/43/Euratom because of the technical, organising and economical problems related with this procedure. The most important task has arisen to prepare procedures according with the current state of knowledge in the area of Quality Assurance (QA) and Quality Control (QC) of medical equipment using ionising radiation in diagnosis. QA and QC in X-ray diagnosis equipment started to be introduced since several years ago and nowadays they are put in common practice in almost each X-ray laboratory in Poland. As result, the nuclear medicine departments must follows the new legislation which has imposed also obligatory necessity of regular Quality Assurance and Quality Control of equipment and procedures for preparing and using radiopharmaceuticals. Documentation for QA system in nuclear medicine includes, among others, quality book, general procedures applied in diagnosis, description of specific procedures prepared in accordance with the rules in current legislation. The physical parameters of equipment (gamma camera, SPECT) undergo the basic tests and some special ones. The basic tests are carried out by staff of the nuclear medicine department. Units with accreditation perform special tests annually. The basic test for planar gamma camera includes: measurement of radioactivity, measurement of background, estimation of photons energy

  9. Economic and Financial Diagnosis - Fundamental Method in Management Accounting

    Directory of Open Access Journals (Sweden)

    Riana Iren RADU

    2012-11-01

    Full Text Available The purpose of the „financial analysis - financial diagnosis phrase is to characterize in a more relevant and more conservative manner the company situation, in order to develop, based on optimal decisions for the establishment and use of resources” . Analysis of company's financial position at a time, usually at the end of the year, permits to assess the size and development of heritage, and making judgments on how to achieve financial balance. In this paper an analysis is made based on diagnostic key economic and financial indicators, calculated using information from the balance sheet and profit and loss account in the period 2006-2011 to Navrom Company Galati, to can measurable effects of the economic crisis on the company.

  10. Molecular Methods To Improve Diagnosis and Identification of Mucormycosis▿

    Science.gov (United States)

    Hammond, Sarah P.; Bialek, Ralf; Milner, Danny A.; Petschnigg, Eva M.; Baden, Lindsey R.; Marty, Francisco M.

    2011-01-01

    Mucormycosis is difficult to diagnose. Samples from suspected cases often fail to grow Mucorales in microbiologic cultures. We identified all hematologic malignancy and stem cell transplant patients diagnosed with proven mucormycosis between 2001 and 2009 at Brigham and Women's Hospital/Dana-Farber Cancer Institute. Seminested PCR targeting Mucorales 18S ribosomal DNA and sequencing were performed on formalin-fixed paraffin-embedded tissue samples. Of 29 cases of mucormycosis, 27 had tissue samples available for PCR and sequencing. Mucorales PCR was positive in 22. Among 12 culture-positive cases, 10 were PCR positive and sequencing was concordant with culture results to the genus level in 9. Among 15 culture-negative cases, PCR was positive and sequencing allowed genus identification in 12. Mucorales PCR is useful for confirmation of the diagnosis of mucormycosis and for further characterization of the infection in cases where cultures are negative. PMID:21508149

  11. Molecular methods to improve diagnosis and identification of mucormycosis.

    Science.gov (United States)

    Hammond, Sarah P; Bialek, Ralf; Milner, Danny A; Petschnigg, Eva M; Baden, Lindsey R; Marty, Francisco M

    2011-06-01

    Mucormycosis is difficult to diagnose. Samples from suspected cases often fail to grow Mucorales in microbiologic cultures. We identified all hematologic malignancy and stem cell transplant patients diagnosed with proven mucormycosis between 2001 and 2009 at Brigham and Women's Hospital/Dana-Farber Cancer Institute. Seminested PCR targeting Mucorales 18S ribosomal DNA and sequencing were performed on formalin-fixed paraffin-embedded tissue samples. Of 29 cases of mucormycosis, 27 had tissue samples available for PCR and sequencing. Mucorales PCR was positive in 22. Among 12 culture-positive cases, 10 were PCR positive and sequencing was concordant with culture results to the genus level in 9. Among 15 culture-negative cases, PCR was positive and sequencing allowed genus identification in 12. Mucorales PCR is useful for confirmation of the diagnosis of mucormycosis and for further characterization of the infection in cases where cultures are negative.

  12. A Combined Fault Diagnosis Method for Power Transformer in Big Data Environment

    Directory of Open Access Journals (Sweden)

    Yan Wang

    2017-01-01

    Full Text Available The fault diagnosis method based on dissolved gas analysis (DGA is of great significance to detect the potential faults of the transformer and improve the security of the power system. The DGA data of transformer in smart grid have the characteristics of large quantity, multiple types, and low value density. In view of DGA big data’s characteristics, the paper first proposes a new combined fault diagnosis method for transformer, in which a variety of fault diagnosis models are used to make a preliminary diagnosis, and then the support vector machine is used to make the second diagnosis. The method adopts the intelligent complementary and blending thought, which overcomes the shortcomings of single diagnosis model in transformer fault diagnosis, and improves the diagnostic accuracy and the scope of application of the model. Then, the training and deployment strategy of the combined diagnosis model is designed based on Storm and Spark platform, which provides a solution for the transformer fault diagnosis in big data environment.

  13. Gastroesophageal reflux diagnosis by scintigraphic method - a comparison among different methods

    International Nuclear Information System (INIS)

    Cruz, Maria das Gracas de Almedia; Penas, Maria Exposito; Maliska, Carmelindo; Fonseca, Lea Miriam B. da; Lemme, Eponina M.; Campos, Deisy Guacyaba S.; Rebelo, Ana Maria de O.; Martinho, Maria Jose R.; Dias, Vera Maria

    1996-01-01

    The gastroesophageal reflux disease is characterized by the return of gastric liquid to the esophagus which can origin the reflux esophagitis. The aim is to evaluate the contribution of dynamic quality scintigraphy of reflux (CTR) in the diagnosis of DRGE. We studied a ground of sick people with typical symptoms and compared the results given by digestive endoscopy (EDA), the histopathology and 24 hours pHmetry. There have been evaluated 24 healthy individuals and 97 who were sick. The first ones were submitted to CTR. In 20 controlled and 34 patients, the reflux index (IR) was determined by the evaluation of the reflux material percentage in relation to the basal activity. All the sick patients were submitted to CTR and EDA. This one classified them in: group A with esophagitis 45 patients (46,4%) where 14 did the biopsy of the third segment/part from the esophagus and 16 did the long pHmetry and group B without esophagitis = 52 patients (53.6%), 26 did the biopsy and 36 the pHmetry. In group A the CTR was positive in 38 (84%), the biopsy showed esophagitis in 11 (78,6%) and the pHmetry showed normal reflux in 14 (87,5%). The positivity of the same exams in group B were of 42 (81%), 11 (42,3%) and 19 (53%) respectively. The IR were determined to the controls and the measure to the patients were of 59% and 106% respectively as p<0,0001 (test from Mann Whitney). The correlation of CTR with the other methods showed sensitivity of 84,1%, specificity of 95,8%, positive predictive value of 98,3% and negative predictive value of 67,7%. As it was showed the authors concluded that the scintigraphy method can confirm the diagnosis of DRGE in patients of typical symptomology which can be recommended by the initial of investigation method in these conditions. (author)

  14. Development of a Long-Column Method to Test Constitutive Relations for LNAPL Movement in Two-Phase Systems

    Science.gov (United States)

    Oostrom, M.; Zhong, L.; Wietsma, T.; Covert, M.

    2007-12-01

    Multifluid relative permeability - saturation - capillary pressure (k-S-P) empirical constitutive models are components of numerical simulators that are used to predict fluid distributions following a nonaqueous phase liquid (NAPL) contamination event or during remediation. The S-P parameter values for these empirical models are either obtained from the literature or determined experimentally by fitting the models to measured data. Most of the experimental emphasis so far has been on testing the S-P component of the k-S-P constitutive relations. Due to the difficulties in obtaining quality relative permeability laboratory data for multiphase systems, testing of the k-S models that are used in multifluid flow simulators has been virtually non-existent. A new tool, the Multiple Location Saturation Pressure Apparatus (MLSPA), located in PNNL's EMSL Subsurface Flow and Transport Laboratory, has been developed to obtain data sets that can be used to test both S-P and k-S relationships for two-phase NAPL-water systems. The MLSPA is a long column (~1 m) equipped with several hydrophilic and hydrophobic pressure transducers. Fluid saturations are determined along the length of a column using a dual-energy gamma radiation system. Although the MLSPA is limited to porous media with a relatively small entry pressure and fairly homogeneous pore-size distributions, it offers the distinct advantage of obtaining S-P data at multiple locations. Besides for static determinations of S-P relations, the MLSPA offers the benefit that it can be used for more dynamic experiments where fluid pressures are changed more rapidly. The data sets produced by the dynamic experiments can be used in relative permeability models. Results of several experiments with crude-oil brine systems will be presented.

  15. Fault Diagnosis Method for a Mine Hoist in the Internet of Things Environment.

    Science.gov (United States)

    Li, Juanli; Xie, Jiacheng; Yang, Zhaojian; Li, Junjie

    2018-06-13

    To reduce the difficulty of acquiring and transmitting data in mining hoist fault diagnosis systems and to mitigate the low efficiency and unreasonable reasoning process problems, a fault diagnosis method for mine hoisting equipment based on the Internet of Things (IoT) is proposed in this study. The IoT requires three basic architectural layers: a perception layer, network layer, and application layer. In the perception layer, we designed a collaborative acquisition system based on the ZigBee short distance wireless communication technology for key components of the mine hoisting equipment. Real-time data acquisition was achieved, and a network layer was created by using long-distance wireless General Packet Radio Service (GPRS) transmission. The transmission and reception platforms for remote data transmission were able to transmit data in real time. A fault diagnosis reasoning method is proposed based on the improved Dezert-Smarandache Theory (DSmT) evidence theory, and fault diagnosis reasoning is performed. Based on interactive technology, a humanized and visualized fault diagnosis platform is created in the application layer. The method is then verified. A fault diagnosis test of the mine hoisting mechanism shows that the proposed diagnosis method obtains complete diagnostic data, and the diagnosis results have high accuracy and reliability.

  16. Imaging method in the diagnosis of pulmonary thromboembolism

    International Nuclear Information System (INIS)

    Medaglia Monge, Luis Gerardo

    2011-01-01

    its usefulness must be demonstrated in all possible scenarios before generalizing their applications. Pulmonary angiography, was in the past the gold standard for the diagnosis of pulmonary thromboembolism, there is sufficient evidence that angioTC can prove, single mode and noninvasive, with increased rates of sensitivity and specificity of the presence of this pathology and optionally be the line first study to confirm the diagnosis. (author) [es

  17. Methylthioadenosine phosphorylase compositions and methods of use in the diagnosis and treatment of proliferative disorders

    Science.gov (United States)

    Olopade, Olufunmilayo I.

    2005-03-22

    Disclosed are novel nucleic acid and peptide compositions comprising methythlioadenosine phosphorylase (MTAP) and methods of use for MTAP amino acid sequences and DNA segments comprising MTAP in the diagnosis of human cancers and development of MTAP-specific antibodies. Also disclosed are methods for the diagnosis and treatment of tumors and other proliferative cell disorders, and idenification tumor suppressor genes and gene products from the human 9p21-p22 chromosome region. Such methods are useful in the diagnosis of multiple tumor types such as bladder cancer, lung cancer, breast cancer, pancreatic cancer, brain tumors, lymphomas, gliomas, melanomas, and leukemias.

  18. Compositions and methods involving methyladenosine phosphorylase in the diagnosis and treatment of proliferative disorders

    Science.gov (United States)

    Olopade, Olufunmilayo I.

    2007-03-20

    Disclosed are novel nucleic acid and peptide compositions comprising methylthioadenosine phosphorylase (MTAP) and methods of use for MTAP amino acid sequences and DNA segments comprising MTAP in the diagnosis of human cancers and development of MTAP-specific antibodies. Also disclosed are methods for the diagnosis and treatment of tumors and other proliferative cell disorders, and identification of tumor suppressor genes and gene products from the human 9p21-p22 chromosome region. Such methods are useful in the diagnosis of multiple tumor types such as bladder cancer, lung cancer, breast cancer, pancreatic cancer, brain tumors, lymphomas, gliomas, melanomas, and leukemias.

  19. Quantitative Diagnosis of Rotor Vibration Fault Using Process Power Spectrum Entropy and Support Vector Machine Method

    Directory of Open Access Journals (Sweden)

    Cheng-Wei Fei

    2014-01-01

    Full Text Available To improve the diagnosis capacity of rotor vibration fault in stochastic process, an effective fault diagnosis method (named Process Power Spectrum Entropy (PPSE and Support Vector Machine (SVM (PPSE-SVM, for short method was proposed. The fault diagnosis model of PPSE-SVM was established by fusing PPSE method and SVM theory. Based on the simulation experiment of rotor vibration fault, process data for four typical vibration faults (rotor imbalance, shaft misalignment, rotor-stator rubbing, and pedestal looseness were collected under multipoint (multiple channels and multispeed. By using PPSE method, the PPSE values of these data were extracted as fault feature vectors to establish the SVM model of rotor vibration fault diagnosis. From rotor vibration fault diagnosis, the results demonstrate that the proposed method possesses high precision, good learning ability, good generalization ability, and strong fault-tolerant ability (robustness in four aspects of distinguishing fault types, fault severity, fault location, and noise immunity of rotor stochastic vibration. This paper presents a novel method (PPSE-SVM for rotor vibration fault diagnosis and real-time vibration monitoring. The presented effort is promising to improve the fault diagnosis precision of rotating machinery like gas turbine.

  20. Brain diagnosis with imaging methods: Psychical changes made visible

    International Nuclear Information System (INIS)

    Anon.

    1988-01-01

    The First International Symposium on Imaging Methods in Psychiatry, held in May 1988 in Wuerzburg, very impressively has shown that imaging methods are on advance not only in medical diagnostics, but also in psychiatric diagnostics, where they already proved to be a valuable tool. (orig./MG) [de

  1. Serological diagnosis of syphilis: a comparison of different diagnostic methods.

    Science.gov (United States)

    Simčič, Saša; Potočnik, Marko

    2015-01-01

    Serological tests' limitations in syphilis diagnosis as well as numerous test interpretations mean that patients with discordant serology results can present diagnostic and treatment challenges for clinicians. We analyzed three common diagnostic algorithms for detecting suspected syphilis in high-prevalence populations in Slovenia. The prospective study included a total of 437 clinical serum samples from adults throughout Slovenia tested with Rapid Plasma Reagin (RPR), Treponema pallidum hemagglutination (TPHA), and an automated chemiluminescence immunoassay (CIA) according to the manufacturer's instructions. In addition to percent agreement, kappa coefficients were calculated as a secondary measure of agreement between the three algorithms. Overall, of 183 subjects that had seroreactive results, 180 were seroreactive in both the reverse sequence and the European Centre for Disease Prevention and Control (ECDC) algorithm. The traditional algorithm had a missed serodiagnosis rate of 30.0%, the overall percent agreement between the traditional and the reverse algorithm (or the ECDC algorithm) was 87.6%, and the kappa value was 0.733. However, the reverse and ECDC algorithm failed to detect three subjects with positive serodiagnosis determined by additional confirmative treponemal assays. Our results supported the ECDC algorithm in the serodiagnosis of syphilis in high-prevalence populations and the use of nontreponemal serology to monitor the response to treatment.

  2. Next Generation Sequencing Methods for Diagnosis of Epilepsy Syndromes

    Directory of Open Access Journals (Sweden)

    Paul Dunn

    2018-02-01

    Full Text Available Epilepsy is a neurological disorder characterized by an increased predisposition for seizures. Although this definition suggests that it is a single disorder, epilepsy encompasses a group of disorders with diverse aetiologies and outcomes. A genetic basis for epilepsy syndromes has been postulated for several decades, with several mutations in specific genes identified that have increased our understanding of the genetic influence on epilepsies. With 70-80% of epilepsy cases identified to have a genetic cause, there are now hundreds of genes identified to be associated with epilepsy syndromes which can be analyzed using next generation sequencing (NGS techniques such as targeted gene panels, whole exome sequencing (WES and whole genome sequencing (WGS. For effective use of these methodologies, diagnostic laboratories and clinicians require information on the relevant workflows including analysis and sequencing depth to understand the specific clinical application and diagnostic capabilities of these gene sequencing techniques. As epilepsy is a complex disorder, the differences associated with each technique influence the ability to form a diagnosis along with an accurate detection of the genetic etiology of the disorder. In addition, for diagnostic testing, an important parameter is the cost-effectiveness and the specific diagnostic outcome of each technique. Here, we review these commonly used NGS techniques to determine their suitability for application to epilepsy genetic diagnostic testing.

  3. Helicobacter pylori in dyspepsia: Phenotypic and genotypic methods of diagnosis

    Directory of Open Access Journals (Sweden)

    Vignesh Shetty

    2017-01-01

    Full Text Available Background: Helicobacter pylori affects almost half of the world's population and therefore is one of the most frequent and persistent bacterial infections worldwide. H. pylori is associated with chronic gastritis, ulcer disease (gastric and duodenal, mucosa-associated lymphoid tissue lymphoma, and gastric cancer. Several diagnostic methods exist to detect infection and the option of one method or another depends on various genes, such as availability, advantages and disadvantages of each method, monetary value, and the age of patients. Materials and Methods: Patients with complaints of abdominal pain, discomfort, acidity, and loss of appetite were chosen for endoscopy, detailed history was contained, and a physical examination was conducted before endoscopy. Biopsies (antrum + body were received from each patient and subjected to rapid urease test (RUT, histopathological examination (HPE, polymerase chain reaction (PCR, and culture. Results: Of the total 223 biopsy specimens obtained from dyspeptic patients, 122 (54.7% were positive for H. pylori for HPE, 109 (48.9% by RUT, 65 (29.1% by culture, and 117 (52.5% by PCR. The specificity and sensitivity were as follows: RUT (99% and 88.5%, phosphoglucosamine mutase PCR assay (100% and 95.9%, and culture (100% and 53.3%, respectively. Conclusion: In this study, we compared the various diagnostic methods used to identify H. pylori infection indicating that, in comparison with histology as gold standard for detection of H. pylori infection, culture and PCR showed 100% specificity whereas RUT and PCR showed 99% and 100% sensitivity, respectively.

  4. A novel method for intelligent fault diagnosis of rolling bearings using ensemble deep auto-encoders

    Science.gov (United States)

    Shao, Haidong; Jiang, Hongkai; Lin, Ying; Li, Xingqiu

    2018-03-01

    Automatic and accurate identification of rolling bearings fault categories, especially for the fault severities and fault orientations, is still a major challenge in rotating machinery fault diagnosis. In this paper, a novel method called ensemble deep auto-encoders (EDAEs) is proposed for intelligent fault diagnosis of rolling bearings. Firstly, different activation functions are employed as the hidden functions to design a series of auto-encoders (AEs) with different characteristics. Secondly, EDAEs are constructed with various auto-encoders for unsupervised feature learning from the measured vibration signals. Finally, a combination strategy is designed to ensure accurate and stable diagnosis results. The proposed method is applied to analyze the experimental bearing vibration signals. The results confirm that the proposed method can get rid of the dependence on manual feature extraction and overcome the limitations of individual deep learning models, which is more effective than the existing intelligent diagnosis methods.

  5. The use of RTG methods for the diagnosis of TMD

    International Nuclear Information System (INIS)

    Ondrasovicova, J.; Jenca, A.

    2008-01-01

    The importance of X-ray examination in diagnosing TMD is used standard, mostly lateral and oblique imaging as summation of the joint structures with the surrounding tissues. X-ray methods can be divided into transfacial, transcranial and subcranial. (authors)

  6. A YinYang bipolar fuzzy cognitive TOPSIS method to bipolar disorder diagnosis.

    Science.gov (United States)

    Han, Ying; Lu, Zhenyu; Du, Zhenguang; Luo, Qi; Chen, Sheng

    2018-05-01

    Bipolar disorder is often mis-diagnosed as unipolar depression in the clinical diagnosis. The main reason is that, different from other diseases, bipolarity is the norm rather than exception in bipolar disorder diagnosis. YinYang bipolar fuzzy set captures bipolarity and has been successfully used to construct a unified inference mathematical modeling method to bipolar disorder clinical diagnosis. Nevertheless, symptoms and their interrelationships are not considered in the existing method, circumventing its ability to describe complexity of bipolar disorder. Thus, in this paper, a YinYang bipolar fuzzy multi-criteria group decision making method to bipolar disorder clinical diagnosis is developed. Comparing with the existing method, the new one is more comprehensive. The merits of the new method are listed as follows: First of all, multi-criteria group decision making method is introduced into bipolar disorder diagnosis for considering different symptoms and multiple doctors' opinions. Secondly, the discreet diagnosis principle is adopted by the revised TOPSIS method. Last but not the least, YinYang bipolar fuzzy cognitive map is provided for the understanding of interrelations among symptoms. The illustrated case demonstrates the feasibility, validity, and necessity of the theoretical results obtained. Moreover, the comparison analysis demonstrates that the diagnosis result is more accurate, when interrelations about symptoms are considered in the proposed method. In a conclusion, the main contribution of this paper is to provide a comprehensive mathematical approach to improve the accuracy of bipolar disorder clinical diagnosis, in which both bipolarity and complexity are considered. Copyright © 2018 Elsevier B.V. All rights reserved.

  7. Method of fault diagnosis in nuclear power plant base on genetic algorithm and knowledge base

    International Nuclear Information System (INIS)

    Zhou Yangping; Zhao Bingquan

    2000-01-01

    Via using the knowledge base, combining Genetic Algorithm and classical probability and contraposing the characteristic of the fault diagnosis of NPP. The authors put forward a method of fault diagnosis. In the process of fault diagnosis, this method contact the state of NPP with the colony in GA and transform the colony to get the individual that adapts to the condition. On the 950MW full size simulator in Beijing NPP simulation training center, experimentation shows it has comparative adaptability to the imperfection of expert knowledge, illusive signal and other instance

  8. A method of the asymmetric Abel's inversion in plasma diagnosis

    International Nuclear Information System (INIS)

    Matoba, Tohru; Funahashi, Akimasa

    1975-09-01

    In the case of a noncylindrical plasma, axis symmetric components are drawn from observed projected intensities of physical quantities, assuming an asymmetric form. And the radial intensity distribution is determined by Abel's inversion method. The best fitting curve is obtained analytically from measured values by the least-square estimation of nonlinear parameters. The cylindrical symmetric Abel's inversion code ( ABELIC ) and the asymmetric Abel's inversion code ( ABELILSENP 2 ) are described. (auth.)

  9. Role of X-ray examination methods in the diagnosis of endophytic stomach carcinomas

    International Nuclear Information System (INIS)

    Gorshkov, A.N.; Akberov, R.F.

    1998-01-01

    Results of studying potentialities of radiographic methods in the diagnosis of stomach endophytic neoplasms (130 cases) are presented. All of patients were exposed to complex radiographic-endoscopic studies of stomach. X-ray computerized tomography is used as an additional method. It is shown that the complex approach to the diagnosis of endophytic neoplasms of stomach is necessary. Radiographic method is proposed to be used as an initial examination method. Endoscopic method with multiple biopsy is also used. X-ray computerized tomography is used for certain anatomic stomach section at the final stage [ru

  10. Alternative methods of determining phase transition temperatures of phospholipids that constitute liposomes on the example of DPPC and DMPC

    Energy Technology Data Exchange (ETDEWEB)

    Pentak, Danuta, E-mail: danuta.pentak@us.edu.pl

    2014-05-01

    Highlights: • New phase transition for DMPC was found. • FT-IR method is an important addition to the DSC studies. • The proposed method for determining the T{sub C} give very consistent results. - Abstract: In this work, alternatives to differential scanning calorimetry (DSC) as a method of determining the main phospholipid phase transition temperature are presented. The bilayer phase transitions from the ripple gel phase (P{sub β{sup ′}}) to the liquid-crystal phase (L{sub α}) of 1,2-dipalmitoyl-sn-glycerol-3-phosphocholine (DPPC) and 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) were studied by differential scanning calorimetry (DSC), Fourier transform infrared (FT-IR), nuclear magnetic resonance (NMR), and electron paramagnetic resonance (EPR) methods. In this work, two correlations between the DSC and FT-IR methods, and NMR and EPR methods are shown. The proposed methods allow for determining the T{sub C} temperature with a high degree of accuracy. Furthermore, a comparison of results obtained using the DSC and FT-IR methods allowed for an observation of a new DMPC phase transition. The liposomes analyzed in this work were obtained by the modified reverse-phase evaporation method (mREV)

  11. Application of learning techniques based on kernel methods for the fault diagnosis in industrial processes

    Directory of Open Access Journals (Sweden)

    Jose M. Bernal-de-Lázaro

    2016-05-01

    Full Text Available This article summarizes the main contributions of the PhD thesis titled: "Application of learning techniques based on kernel methods for the fault diagnosis in Industrial processes". This thesis focuses on the analysis and design of fault diagnosis systems (DDF based on historical data. Specifically this thesis provides: (1 new criteria for adjustment of the kernel methods used to select features with a high discriminative capacity for the fault diagnosis tasks, (2 a proposed approach process monitoring using statistical techniques multivariate that incorporates a reinforced information concerning to the dynamics of the Hotelling's T2 and SPE statistics, whose combination with kernel methods improves the detection of small-magnitude faults; (3 an robustness index to compare the diagnosis classifiers performance taking into account their insensitivity to possible noise and disturbance on historical data.

  12. Research on fault diagnosis with SDG method for nuclear power plant

    International Nuclear Information System (INIS)

    Liu Yongkuo; Liu Zhen; Wu Xiaotian

    2014-01-01

    Abstract: The diagnosis of the operational state of a nuclear power plant (NPP) plays an important role for the safety and reliability of NPP operation. In this paper, the qualitative method for fault diagnosis based on signed directed graph (SDG) was applied in a complex NPP system because the mathematical model of NPP is difficult to be built. The reactor coolant system (RCS) was taken as the diagnostic object, and the approach of building SDG model was presented and the SDG model of the RCS was built. Based on the SDG model, a fault diagnosis system of RCS was developed, and the steam generator tube rupture (SGTR) and rod ejection accidents were taken as example to analyze the process of diagnosis inference. The simulation results show that the method based on SDG can effectively diagnose the fault in RCS, and it can also provide good explanation for the fault propagation paths. Therefore, this method can help operators to make correct decisions. (authors)

  13. Application of the microscopic method in cutaneous leishmania diagnosis

    Directory of Open Access Journals (Sweden)

    Mohammed Wael Daboul

    2011-10-01

    Full Text Available Introduction: Cutaneous leishmania is spreading fast. This study aims at developing the microscopic method to achieve a full detection of all positive cases of leishmania.Methods: 50 human cases have been studied by applying microscopic smears stained with Wright stain. Microscopic photos were taken for the presumed unfamiliar figures.Results: Mononuclear cells with tails are present at a rate of (98%. They are associated with Leishman Donovan (LD bodies in 50% of the cases. The polygonal figures and the spherical forms are present at the same rate (60% and are associated with LD bodies in 24% of the cases. The small promastigote like forms are seen at a rate of (76% and are associated with LD bodies in 26% of the cases. The giant promastigotes like forms are present in (80% of the cases and are associated with LD bodies in 28% of the cases. Candle flame forms are present in (40% of the cases and are associated with the LD bodies in 21% of the cases.Discussion: It is applicable to use those discovered figures in diagnosing cutaneous leishmania.

  14. Diagnosis methods based on noise analysis at Cernavoda NPP, Romania

    International Nuclear Information System (INIS)

    Banica, Constantin; Dobrea, Dumitru

    1999-01-01

    This paper describes a recent noise analysis of the neutronic signals provided by in-core flux detectors (ICFD) and ion chambers (IC). This analysis is part of on-going program developed for Unit 1 of the Cernavoda NPP, Romania, with the following main objectives: - prediction of detector failures based on pattern recognition; - determination of fast excursions from steady states; - detection of abnormal mechanical vibrations in the reactor core. The introduction presents briefly the reactor, the location of ICFD's and IC's. The second section presents the data acquisition systems and their capabilities. The paper continues with a brief presentation of the numerical methods used for analysis (section 3). The most significant results can be found in section 4, while section 5 concludes about useful information that can be obtained from the neutronic signals at high power steady-state operation. (authors)

  15. Tangent modulus in numerical integration of constitutive relations and its influence on convergence of N-R method

    Directory of Open Access Journals (Sweden)

    Poruba Z.

    2009-06-01

    Full Text Available For the numerical solution of elasto-plastic problems with use of Newton-Raphson method in global equilibrium equation it is necessary to determine the tangent modulus in each integration point. To reach the parabolic convergence of Newton-Raphson method it is convenient to use so called algorithmic tangent modulus which is consistent with used integration scheme. For more simple models for example Chaboche combined hardening model it is possible to determine it in analytical way. In case of more robust macroscopic models it is in many cases necessary to use the approximation approach. This possibility is presented in this contribution for radial return method on Chaboche model. An example solved in software Ansys corresponds to line contact problem with assumption of Coulomb's friction. The study shows at the end that the number of iteration of N-R method is higher in case of continuum tangent modulus and many times higher with use of modified N-R method, initial stiffness method.

  16. Sensitivity of radiation methods of diagnosis of electric potentials in dielectric materials

    International Nuclear Information System (INIS)

    Sapozhkov, Yu.I.; Smekalin, L.F.; Yagushkin, N.I.

    1985-01-01

    On the base of the albedo method the characteristics of radiation methods of diagnosis of electric potentials inside dielectrics, such as sensitivity and resolution are considered. Investigations are carried out for electron energies of tens keV. It is shown that with energy growth the sensitivity to electric field in the dielectrics volume drops. The target atomic number growth reduces the sensitivity approximately 1/lnz. The albedo method resolution in the investigated energy range is constant. The results obtained testify to the usability radiation methods of the diagnosis for control of electric fields of dielectric structural materials in the course of their operation

  17. Advances in intelligent diagnosis methods for pulmonary ground-glass opacity nodules.

    Science.gov (United States)

    Yang, Jing; Wang, Hailin; Geng, Chen; Dai, Yakang; Ji, Jiansong

    2018-02-07

    Pulmonary nodule is one of the important lesions of lung cancer, mainly divided into two categories of solid nodules and ground glass nodules. The improvement of diagnosis of lung cancer has significant clinical significance, which could be realized by machine learning techniques. At present, there have been a lot of researches focusing on solid nodules. But the research on ground glass nodules started late, and lacked research results. This paper summarizes the research progress of the method of intelligent diagnosis for pulmonary nodules since 2014. It is described in details from four aspects: nodular signs, data analysis methods, prediction models and system evaluation. This paper aims to provide the research material for researchers of the clinical diagnosis and intelligent analysis of lung cancer, and further improve the precision of pulmonary ground glass nodule diagnosis.

  18. Research on Big Data Attribute Selection Method in Submarine Optical Fiber Network Fault Diagnosis Database

    Directory of Open Access Journals (Sweden)

    Chen Ganlang

    2017-11-01

    Full Text Available At present, in the fault diagnosis database of submarine optical fiber network, the attribute selection of large data is completed by detecting the attributes of the data, the accuracy of large data attribute selection cannot be guaranteed. In this paper, a large data attribute selection method based on support vector machines (SVM for fault diagnosis database of submarine optical fiber network is proposed. Mining large data in the database of optical fiber network fault diagnosis, and calculate its attribute weight, attribute classification is completed according to attribute weight, so as to complete attribute selection of large data. Experimental results prove that ,the proposed method can improve the accuracy of large data attribute selection in fault diagnosis database of submarine optical fiber network, and has high use value.

  19. Fuzzy method for pre-diagnosis of breast cancer from the Fine Needle Aspirate analysis

    Directory of Open Access Journals (Sweden)

    Sizilio Gláucia RMA

    2012-11-01

    Full Text Available Abstract Background Across the globe, breast cancer is one of the leading causes of death among women and, currently, Fine Needle Aspirate (FNA with visual interpretation is the easiest and fastest biopsy technique for the diagnosis of this deadly disease. Unfortunately, the ability of this method to diagnose cancer correctly when the disease is present varies greatly, from 65% to 98%. This article introduces a method to assist in the diagnosis and second opinion of breast cancer from the analysis of descriptors extracted from smears of breast mass obtained by FNA, with the use of computational intelligence resources - in this case, fuzzy logic. Methods For data acquisition of FNA, the Wisconsin Diagnostic Breast Cancer Data (WDBC, from the University of California at Irvine (UCI Machine Learning Repository, available on the internet through the UCI domain was used. The knowledge acquisition process was carried out by the extraction and analysis of numerical data of the WDBC and by interviews and discussions with medical experts. The PDM-FNA-Fuzzy was developed in four steps: 1 Fuzzification Stage; 2 Rules Base; 3 Inference Stage; and 4 Defuzzification Stage. Performance cross-validation was used in the tests, with three databases with gold pattern clinical cases randomly extracted from the WDBC. The final validation was held by medical specialists in pathology, mastology and general practice, and with gold pattern clinical cases, i.e. with known and clinically confirmed diagnosis. Results The Fuzzy Method developed provides breast cancer pre-diagnosis with 98.59% sensitivity (correct pre-diagnosis of malignancies; and 85.43% specificity (correct pre-diagnosis of benign cases. Due to the high sensitivity presented, these results are considered satisfactory, both by the opinion of medical specialists in the aforementioned areas and by comparison with other studies involving breast cancer diagnosis using FNA. Conclusions This paper presents an

  20. A Novel Fault Diagnosis Method for Rotating Machinery Based on a Convolutional Neural Network.

    Science.gov (United States)

    Guo, Sheng; Yang, Tao; Gao, Wei; Zhang, Chen

    2018-05-04

    Fault diagnosis is critical to ensure the safety and reliable operation of rotating machinery. Most methods used in fault diagnosis of rotating machinery extract a few feature values from vibration signals for fault diagnosis, which is a dimensionality reduction from the original signal and may omit some important fault messages in the original signal. Thus, a novel diagnosis method is proposed involving the use of a convolutional neural network (CNN) to directly classify the continuous wavelet transform scalogram (CWTS), which is a time-frequency domain transform of the original signal and can contain most of the information of the vibration signals. In this method, CWTS is formed by discomposing vibration signals of rotating machinery in different scales using wavelet transform. Then the CNN is trained to diagnose faults, with CWTS as the input. A series of experiments is conducted on the rotor experiment platform using this method. The results indicate that the proposed method can diagnose the faults accurately. To verify the universality of this method, the trained CNN was also used to perform fault diagnosis for another piece of rotor equipment, and a good result was achieved.

  1. Development of an Agrobacterium-Mediated Transformation Method and Evaluation of Two Exogenous Constitutive Promoters in Oleaginous Yeast Lipomyces starkeyi.

    Science.gov (United States)

    Lin, Xinping; Liu, Sasa; Bao, Ruiqi; Gao, Ning; Zhang, Sufang; Zhu, Rongqian; Zhao, Zongbao Kent

    2017-11-01

    Oleaginous yeast Lipomyces starkeyi, a promising strain of great biotechnical importance, is able to accumulate over 60% of its cell biomass as triacylglycerols (TAGs). It is promising to directly produce the derivatives of TAGs, such as long-chain fatty acid methyl esters and alkanes, in L. starkeyi. However, techniques for genetic modification of this oleaginous yeast are lacking, thus, further research is needed to develop genetic tools and functional elements. Here, we used two exogenous promoters (pGPD and pPGK) from oleaginous yeast Rhodosporidium toruloides to establish a simpler Agrobacterium-mediated transformation (AMT) method for L. starkeyi. Hygromycin-resistant transformants were obtained on antibiotic-contained plate. Mitotic stability test, genotype verification by PCR, and protein expression confirmation all demonstrated the success of this method. Furthermore, the strength of these two promoters was evaluated at the phenotypic level on a hygromycin-gradient plate and at the transcriptional level by real-time quantitative PCR. The PGK promoter strength was 2.2-fold as that of GPD promoter to initiate the expression of the hygromycin-resistance gene. This study provided an easy and efficient genetic manipulation method and elements of the oleaginous yeast L. starkeyi for constructing superior strains to produce advanced biofuels.

  2. Diagnosis of Diabetes Using Computer Methods: Soft Computing Methods for Diabetes Detection Using Iris

    OpenAIRE

    Piyush Samant; Ravinder Agarwal

    2017-01-01

    Complementary and Alternative Medicine (CAM) techniques are quite popular and effective for chronic diseases. Iridology is more than 150 years old CAM technique which analyzes the patterns, tissue weakness, color, shape, structure, etc. for disease diagnosis. The objective of this paper is to validate the use of iridology for the diagnosis of the diabetes. The suggested model was applied in a systemic disease with ocular effects. 200 subject data of 100 each diabetic and non-diabetic were eva...

  3. Identification of constitutive theory parameters using a tensile machine for deposited filaments of microcrystalline ink by the direct-write method

    International Nuclear Information System (INIS)

    Lourdel, N; Therriault, D; Lévesque, M

    2009-01-01

    A custom-designed tensile machine is developed to characterize the mechanical properties of ink micro-filaments deposited by the direct-write method. The direct-write method has been used for the fabrication of a wide variety of micro-systems such as microvascular networks, chaotic mixers and laboratory on chips. The tensile machine was used to measure the induced force in ink filaments during tensile and tension-relaxation tests as a function of the applied strain rate, the ink composition and the filament diameter. Experimental data were fitted by a linearly viscoelastic model using a data reduction procedure in order to identify the constitutive theory parameters of the deposited ink filaments. The model predictions based on the linearly viscoelastic model and the defined constitutive theory parameters give a close approximation of all experimental data generated in this study. Such models will be useful for the development and optimization of future 3D complex structures made by the direct-write method

  4. Research on Fault Diagnosis Method Based on Rule Base Neural Network

    Directory of Open Access Journals (Sweden)

    Zheng Ni

    2017-01-01

    Full Text Available The relationship between fault phenomenon and fault cause is always nonlinear, which influences the accuracy of fault location. And neural network is effective in dealing with nonlinear problem. In order to improve the efficiency of uncertain fault diagnosis based on neural network, a neural network fault diagnosis method based on rule base is put forward. At first, the structure of BP neural network is built and the learning rule is given. Then, the rule base is built by fuzzy theory. An improved fuzzy neural construction model is designed, in which the calculated methods of node function and membership function are also given. Simulation results confirm the effectiveness of this method.

  5. Development of an analysis rule of diagnosis error for standard method of human reliability analysis

    International Nuclear Information System (INIS)

    Jeong, W. D.; Kang, D. I.; Jeong, K. S.

    2003-01-01

    This paper presents the status of development of Korea standard method for Human Reliability Analysis (HRA), and proposed a standard procedure and rules for the evaluation of diagnosis error probability. The quality of KSNP HRA was evaluated using the requirement of ASME PRA standard guideline, and the design requirement for the standard HRA method was defined. Analysis procedure and rules, developed so far, to analyze diagnosis error probability was suggested as a part of the standard method. And also a study of comprehensive application was performed to evaluate the suitability of the proposed rules

  6. SNPs and real-time quantitative PCR method for constitutional allelic copy number determination, the VPREB1 marker case

    Directory of Open Access Journals (Sweden)

    Costa Elena

    2011-05-01

    Full Text Available Abstract Background 22q11.2 microdeletion is responsible for the DiGeorge Syndrome, characterized by heart defects, psychiatric disorders, endocrine and immune alterations and a 1 in 4000 live birth prevalence. Real-time quantitative PCR (qPCR approaches for allelic copy number determination have recently been investigated in 22q11.2 microdeletions detection. The qPCR method was performed for 22q11.2 microdeletions detection as a first-level screening approach in a genetically unknown series of patients with congenital heart defects. A technical issue related to the VPREB1 qPCR marker was pointed out. Methods A set of 100 unrelated Italian patients with congenital heart defects were tested for 22q11.2 microdeletions by a qPCR method using six different markers. Fluorescence In Situ Hybridization technique (FISH was used for confirmation. Results qPCR identified six patients harbouring the 22q11.2 microdeletion, confirmed by FISH. The VPREB1 gene marker presented with a pattern consistent with hemideletion in one 3 Mb deleted patient, suggestive for a long distal deletion, and in additional five non-deleted patients. The long distal 22q11.2 deletion was not confirmed by Comparative Genomic Hybridization. Indeed, the VPREB1 gene marker generated false positive results in association with the rs1320 G/A SNP, a polymorphism localized within the VPREB1 marker reverse primer sequence. Patients heterozygous for rs1320 SNP, showed a qPCR profile consistent with the presence of a hemideletion. Conclusions Though the qPCR technique showed advantages as a screening approach in terms of cost and time, the VPREB1 marker case revealed that single nucleotide polymorphisms can interfere with qPCR data generating erroneous allelic copy number interpretations.

  7. METHODS AND PROCEDURES FOR COMPREHENSIVE DIAGNOSIS OF RISKS OF THE ENTERPRISES OF REAL SECTOR OF ECONOMY

    Directory of Open Access Journals (Sweden)

    A. M. Medvedeva

    2010-01-01

    Full Text Available The article covers a conceptually new method of industrial Company Risks’ complex Diagnosis. This method orders the possibility of diagnosing these risks as events resulting from each of the factors and leading to the changes of the company and company’s systems/subdivisions activities’ results.

  8. Two Thermoeconomic Diagnosis Methods Applied to Representative Operating Data of a Commercial Transcritical Refrigeration Plant

    DEFF Research Database (Denmark)

    Ommen, Torben Schmidt; Sigthorsson, Oskar; Elmegaard, Brian

    2017-01-01

    In order to investigate options for improving the maintenance protocol of commercial refrigeration plants, two thermoeconomic diagnosis methods were evaluated on a state-of-the-art refrigeration plant. A common relative indicator was proposed for the two methods in order to directly compare the q...

  9. Joint Parametric Fault Diagnosis and State Estimation Using KF-ML Method

    DEFF Research Database (Denmark)

    Sun, Zhen; Yang, Zhenyu

    2014-01-01

    The paper proposes a new method for a kind of parametric fault online diagnosis with state estimation jointly. The considered fault affects not only the deterministic part of the system but also the random circumstance. The proposed method first applies Kalman Filter (KF) and Maximum Likelihood (...

  10. The Constitutional Amendment Process

    Science.gov (United States)

    Chism, Kahlil

    2005-01-01

    This article discusses the constitutional amendment process. Although the process is not described in great detail, Article V of the United States Constitution allows for and provides instruction on amending the Constitution. While the amendment process currently consists of six steps, the Constitution is nevertheless quite difficult to change.…

  11. A new diagnosis method using alarm annunciation for nuclear power plants

    International Nuclear Information System (INIS)

    Ozaki, Yoshihiko; Suda, Kazunori; Ozawa, Kenji

    1997-01-01

    We discuss the methodology diversity for diagnosis reasoning in an autonomous operation system, and propose a new diagnosis method using an alarm annunciation system. The combination of annunciated alarms is expected to be peculiar to the anomalous phenomenon or accident. Moreover, as the state of affairs is developing, each appearance of the pattern is changing with time peculiarly to each anomaly or accident. The matter is utilized for the new diagnosis method. The patterns of annunciated alarms with progress of the events are prepared in advance under the condition of the anomalies or accidents by use of a plant simulator. The diagnostic reasoning can be done by comparing the obtained combination of annunciated alarms with the reference templates by using pattern matching method. On the other hand, we have another method, called COBWEB used for conceptual classification in cognitive science, to reason for diagnosis. We have carried out the experiments using the loop type LMFBR plant simulator to obtain the various combinations of annunciated alarms with progress of the events under the conditions of anomalies and accidents. The examined cases were related to the anomalies and accidents in the water/steam system of the LMFBR power plant. The simulation examination showed that each change of the pattern of annunciated alarms is specific to each anomaly or accident, and we have applied the pattern matching technique and COBWEB methods into the diagnostic reasoning using annunciated alarms. We could show the capability of these two methods to reason and focus among various candidates of causes of anomalies with gradually improved conviction degree as time passes from the occurrence of anomalies. It was also confirmed that these methods are effective in diagnosis reasoning as a way the operators are doing the diagnosis reasoning in existing plants. (author)

  12. Fault Diagnosis for Rotating Machinery: A Method based on Image Processing.

    Directory of Open Access Journals (Sweden)

    Chen Lu

    Full Text Available Rotating machinery is one of the most typical types of mechanical equipment and plays a significant role in industrial applications. Condition monitoring and fault diagnosis of rotating machinery has gained wide attention for its significance in preventing catastrophic accident and guaranteeing sufficient maintenance. With the development of science and technology, fault diagnosis methods based on multi-disciplines are becoming the focus in the field of fault diagnosis of rotating machinery. This paper presents a multi-discipline method based on image-processing for fault diagnosis of rotating machinery. Different from traditional analysis method in one-dimensional space, this study employs computing method in the field of image processing to realize automatic feature extraction and fault diagnosis in a two-dimensional space. The proposed method mainly includes the following steps. First, the vibration signal is transformed into a bi-spectrum contour map utilizing bi-spectrum technology, which provides a basis for the following image-based feature extraction. Then, an emerging approach in the field of image processing for feature extraction, speeded-up robust features, is employed to automatically exact fault features from the transformed bi-spectrum contour map and finally form a high-dimensional feature vector. To reduce the dimensionality of the feature vector, thus highlighting main fault features and reducing subsequent computing resources, t-Distributed Stochastic Neighbor Embedding is adopt to reduce the dimensionality of the feature vector. At last, probabilistic neural network is introduced for fault identification. Two typical rotating machinery, axial piston hydraulic pump and self-priming centrifugal pumps, are selected to demonstrate the effectiveness of the proposed method. Results show that the proposed method based on image-processing achieves a high accuracy, thus providing a highly effective means to fault diagnosis for

  13. Fault Diagnosis for Rotating Machinery: A Method based on Image Processing.

    Science.gov (United States)

    Lu, Chen; Wang, Yang; Ragulskis, Minvydas; Cheng, Yujie

    2016-01-01

    Rotating machinery is one of the most typical types of mechanical equipment and plays a significant role in industrial applications. Condition monitoring and fault diagnosis of rotating machinery has gained wide attention for its significance in preventing catastrophic accident and guaranteeing sufficient maintenance. With the development of science and technology, fault diagnosis methods based on multi-disciplines are becoming the focus in the field of fault diagnosis of rotating machinery. This paper presents a multi-discipline method based on image-processing for fault diagnosis of rotating machinery. Different from traditional analysis method in one-dimensional space, this study employs computing method in the field of image processing to realize automatic feature extraction and fault diagnosis in a two-dimensional space. The proposed method mainly includes the following steps. First, the vibration signal is transformed into a bi-spectrum contour map utilizing bi-spectrum technology, which provides a basis for the following image-based feature extraction. Then, an emerging approach in the field of image processing for feature extraction, speeded-up robust features, is employed to automatically exact fault features from the transformed bi-spectrum contour map and finally form a high-dimensional feature vector. To reduce the dimensionality of the feature vector, thus highlighting main fault features and reducing subsequent computing resources, t-Distributed Stochastic Neighbor Embedding is adopt to reduce the dimensionality of the feature vector. At last, probabilistic neural network is introduced for fault identification. Two typical rotating machinery, axial piston hydraulic pump and self-priming centrifugal pumps, are selected to demonstrate the effectiveness of the proposed method. Results show that the proposed method based on image-processing achieves a high accuracy, thus providing a highly effective means to fault diagnosis for rotating machinery.

  14. Lessons learned with molecular methods targeting the BCSP-31 membrane protein for diagnosis of human brucellosis.

    Science.gov (United States)

    Sanjuan-Jimenez, Rocio; Colmenero, Juan D; Morata, Pilar

    2017-06-01

    Brucellosis remains an emerging and re-emerging zoonosis worldwide causing high human morbidity. It usually affects persons who are permanently exposed to fastidious microorganisms of the Brucella genus and has a nonspecific clinical picture. Thus, diagnosis of brucellosis can sometimes be difficult. Molecular techniques have recently been found very useful in the diagnosis of brucellosis together with its common and very diverse focal complications. We herein review all the lessons learned by our group concerning the molecular diagnosis of human brucellosis over the last twenty years. The results, initially using one-step conventional PCR, later PCR-ELISA and more recently real-time PCR, using both fluorescent intercalating reagents (SYBR-Green I) and specific probes (Taqman), have shown that these techniques are all much more sensitive than bacteriological methods and more specific than the usual serological techniques for the diagnosis of primary infection, the post-treatment control of the disease, early detection of relapse and the diagnosis of focal complications. Optimization of the technique and improvements introduced over the years show that molecular methods, currently accessible for most clinical laboratories, enable easy rapid diagnosis of brucellosis at the same time as they avoid any risk to laboratory personnel while handling live Brucella spp. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. A new method of knowledge processing for equipment diagnosis of nuclear power plants

    International Nuclear Information System (INIS)

    Fujii, M.; Fukumoto, A.; Tai, I.; Morioka, T.

    1987-01-01

    In this work, the authors complete the development of a new knowledge processing method and representation for equipment diagnosis of nuclear power plants and evaluate its functions by applying to the maintenance and diagnosis support system of the reactor instrumentation. This knowledge processing method system is based on the Cause Generation and Checking concept and has sufficient performance not only in the diagnosis function but also in the man-machine interfacing function. The maintenance and diagnosis support system based on this method leads to the possibility for users to diagnose various phenomena occurred in an objective equipment to the considerable extent by consulting with the system, even if they don't have enough knowledge. With this system, it becomes easy for operators or plant engineers to take immediate actions to counteract against the abnormality. The maintainability of the equipments is improved and MTTR (Mean Time To Repair) is expected to be shorter. This new knowledge processing method is proved to be suited for fault diagnosis of the equipments of nuclear power plants

  16. Application of Integrated Neural Network Method to Fault Diagnosis of Nuclear Steam Generator

    International Nuclear Information System (INIS)

    Zhou Gang; Yang Li

    2009-01-01

    A new fault diagnosis method based on integrated neural networks for nuclear steam generator (SG) was proposed in view of the shortcoming of the conventional fault monitoring and diagnosis method. In the method, two neural networks (ANNs) were employed for the fault diagnosis of steam generator. A neural network, which was used for predicting the values of steam generator operation parameters, was taken as the dynamics model of steam generator. The principle of fault monitoring method using the neural network model is to detect the deviations between process signals measured from an operating steam generator and corresponding output signals from the neural network model of steam generator. When the deviation exceeds the limit set in advance, the abnormal event is thought to occur. The other neural network as a fault classifier conducts the fault classification of steam generator. So, the fault types of steam generator are given by the fault classifier. The clear information on steam generator faults was obtained by fusing the monitoring and diagnosis results of two neural networks. The simulation results indicate that employing integrated neural networks can improve the capacity of fault monitoring and diagnosis for the steam generator. (authors)

  17. A fault diagnosis method based on signed directed graph and matrix for nuclear power plants

    International Nuclear Information System (INIS)

    Liu, Yong-Kuo; Wu, Guo-Hua; Xie, Chun-Li; Duan, Zhi-Yong; Peng, Min-Jun; Li, Meng-Kun

    2016-01-01

    Highlights: • “Rules matrix” is proposed for FDD. • “State matrix” is proposed to solve SDG online inference. • SDG inference and search method are combined for FDD. - Abstract: In order to solve SDG online fault diagnosis and inference, matrix diagnosis and inference methods are proposed for fault detection and diagnosis (FDD). Firstly, “rules matrix” based on SDG model is used for FDD. Secondly, “status matrix” is proposed to achieve SDG online inference. According to different diagnosis results, “status matrix” is applied for the depth-first search and the breadth-first search respectively to find the propagation paths of each fault. Finally, the SDG model of the secondary-loop system in pressurized water reactor (PWR) is built to verify the effectiveness of the proposed method. The simulation experiment results indicate that the “status matrix” used for online inference can be used to find the fault propagation paths and to explain the causes for fault. Therefore, it can be concluded that the proposed method is one of the fault diagnosis for nuclear power plants (NPPs), which can be used to facilitate the development of fault diagnostic system.

  18. A fault diagnosis method based on signed directed graph and matrix for nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Yong-Kuo, E-mail: LYK08@126.com [Fundamental Science on Nuclear Safety and Simulation Technology Laboratory, Harbin Engineering University, Harbin 150001 (China); Wu, Guo-Hua [Fundamental Science on Nuclear Safety and Simulation Technology Laboratory, Harbin Engineering University, Harbin 150001 (China); Institute of Nuclear Energy Technology, Tsinghua University, Beijing 100084 (China); Xie, Chun-Li [Traffic College, Northeast Forestry University, Harbin, 150040 (China); Duan, Zhi-Yong; Peng, Min-Jun; Li, Meng-Kun [Fundamental Science on Nuclear Safety and Simulation Technology Laboratory, Harbin Engineering University, Harbin 150001 (China)

    2016-02-15

    Highlights: • “Rules matrix” is proposed for FDD. • “State matrix” is proposed to solve SDG online inference. • SDG inference and search method are combined for FDD. - Abstract: In order to solve SDG online fault diagnosis and inference, matrix diagnosis and inference methods are proposed for fault detection and diagnosis (FDD). Firstly, “rules matrix” based on SDG model is used for FDD. Secondly, “status matrix” is proposed to achieve SDG online inference. According to different diagnosis results, “status matrix” is applied for the depth-first search and the breadth-first search respectively to find the propagation paths of each fault. Finally, the SDG model of the secondary-loop system in pressurized water reactor (PWR) is built to verify the effectiveness of the proposed method. The simulation experiment results indicate that the “status matrix” used for online inference can be used to find the fault propagation paths and to explain the causes for fault. Therefore, it can be concluded that the proposed method is one of the fault diagnosis for nuclear power plants (NPPs), which can be used to facilitate the development of fault diagnostic system.

  19. A sequential fuzzy diagnosis method for rotating machinery using ant colony optimization and possibility theory

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Hao; Ping, Xueliang; Cao, Yi; Lie, Ke [Jiangnan University, Wuxi (China); Chen, Peng [Mie University, Mie (Japan); Wang, Huaqing [Beijing University, Beijing (China)

    2014-04-15

    This study proposes a novel intelligent fault diagnosis method for rotating machinery using ant colony optimization (ACO) and possibility theory. The non-dimensional symptom parameters (NSPs) in the frequency domain are defined to reflect the features of the vibration signals measured in each state. A sensitive evaluation method for selecting good symptom parameters using principal component analysis (PCA) is proposed for detecting and distinguishing faults in rotating machinery. By using ACO clustering algorithm, the synthesizing symptom parameters (SSP) for condition diagnosis are obtained. A fuzzy diagnosis method using sequential inference and possibility theory is also proposed, by which the conditions of the machinery can be identified sequentially. Lastly, the proposed method is compared with a conventional neural networks (NN) method. Practical examples of diagnosis for a V-belt driving equipment used in a centrifugal fan are provided to verify the effectiveness of the proposed method. The results verify that the faults that often occur in V-belt driving equipment, such as a pulley defect state, a belt defect state and a belt looseness state, are effectively identified by the proposed method, while these faults are difficult to detect using conventional NN.

  20. Constitutional Rights in Indonesia

    OpenAIRE

    Judhariksawan

    2018-01-01

    The constitution is fundamental to the life of the modern state as a major foothold in state governance. Includes the guarantee of constitutional rights of citizens. The The constitution is the basis of state organizers to be implemented so that the state is obliged to guarantee the fulfillment of citizens' constitutional rights. Human rights have become an important part of the modern constitution. This study will describe how human rights guarantees become part of consti...

  1. A new diagnosis method using alarm annunciation for FBR power plants

    International Nuclear Information System (INIS)

    Ozaki, Y.; Suda, K.; Yoshikawa, S.; Ozawa, K.

    1997-01-01

    We discuss the methodology diversity for diagnosis reasoning in autonomous operation system, and propose a new diagnosis method using alarm annunciation system. The methodology diversity is assured by preparing plural agents, each of which is based on its own different methodology, therefore, it is expected for the reliability in diagnosis to be improved. Meanwhile, the combination of annunciated alarms is expected to be peculiar to the anomalous phenomenon or accident. Moreover, as the state of affairs is developing, each appearance of the pattern is changing with time peculiarly to each anomaly or accident. The matter is utilized for the new diagnosis method. The patterns of annunciated alarms with progress of the events are prepared in advance under the condition of the anomalies or accidents by use of plant simulatory. The diagnostic reasoning can be done by comparing the obtained combination of annunciated alarms with the reference templates, pattern matching method. On the other hand, we have another method, called as COBWEB used for conceptual classification in cognitive science, to reason for diagnosis. We have carried out the experiments using the loop type LMFBR plant simulator to obtain the various combinations of annunciated alarms with progress of the events under the conditions of anomalies and accidents. The examined cases were related to the anomalies and accidents in the water/steam system of the LMFBR power plant. We have obtained the conclusions that it is effective to reason the causes of anomalies using the annunciated alarms. We are going to apply the pattern matching technique or COBWEB method into the diagnostic reasoning to confirm the performance of the proposed diagnosis method based on the alarm annunciation. (author). 5 refs, 14 figs

  2. Constitutional changes and the dilemmas of constitutionalism

    Directory of Open Access Journals (Sweden)

    Arsen Bačić

    2009-01-01

    Full Text Available The need to develop constitutional mechanisms whose aim is to resolve fundamental relations in society demands the widest possible inclusion of all of society’s active participants in the discussion on the need to adopt or revise the Constitution. The opening of every new round of constitutional changes is of great importance because it always unlocks certain new and important questions. The answers to those questions should be offered by state authority (policy and civil society including science and its disciplines. In this paper, the author mentions several topics which are of interest in the current discussion on the significance of current constitutional changes for the future of the development of constitutionalism and democracy in the Republic of Croatia. These are above all topics of political and legal constitutionalism and suggestions linked to strengthening the independence of judicial powers. The author advocates consistent application of constitutional control and check mechanisms which exclude all insularity of judicial powers in relation to democratic control.

  3. Clostridium difficile infection: Early history, diagnosis and molecular strain typing methods.

    Science.gov (United States)

    Rodriguez, C; Van Broeck, J; Taminiau, B; Delmée, M; Daube, G

    2016-08-01

    Recognised as the leading cause of nosocomial antibiotic-associated diarrhoea, the incidence of Clostridium difficile infection (CDI) remains high despite efforts to improve prevention and reduce the spread of the bacterium in healthcare settings. In the last decade, many studies have focused on the epidemiology and rapid diagnosis of CDI. In addition, different typing methods have been developed for epidemiological studies. This review explores the history of C. difficile and the current scope of the infection. The variety of available laboratory tests for CDI diagnosis and strain typing methods are also examined. Copyright © 2016 Elsevier Ltd. All rights reserved.

  4. Nonparametric Change Point Diagnosis Method of Concrete Dam Crack Behavior Abnormality

    Directory of Open Access Journals (Sweden)

    Zhanchao Li

    2013-01-01

    Full Text Available The study on diagnosis method of concrete crack behavior abnormality has always been a hot spot and difficulty in the safety monitoring field of hydraulic structure. Based on the performance of concrete dam crack behavior abnormality in parametric statistical model and nonparametric statistical model, the internal relation between concrete dam crack behavior abnormality and statistical change point theory is deeply analyzed from the model structure instability of parametric statistical model and change of sequence distribution law of nonparametric statistical model. On this basis, through the reduction of change point problem, the establishment of basic nonparametric change point model, and asymptotic analysis on test method of basic change point problem, the nonparametric change point diagnosis method of concrete dam crack behavior abnormality is created in consideration of the situation that in practice concrete dam crack behavior may have more abnormality points. And the nonparametric change point diagnosis method of concrete dam crack behavior abnormality is used in the actual project, demonstrating the effectiveness and scientific reasonableness of the method established. Meanwhile, the nonparametric change point diagnosis method of concrete dam crack behavior abnormality has a complete theoretical basis and strong practicality with a broad application prospect in actual project.

  5. Sequential Fuzzy Diagnosis Method for Motor Roller Bearing in Variable Operating Conditions Based on Vibration Analysis

    Directory of Open Access Journals (Sweden)

    Yi Cao

    2013-06-01

    Full Text Available A novel intelligent fault diagnosis method for motor roller bearings which operate under unsteady rotating speed and load is proposed in this paper. The pseudo Wigner-Ville distribution (PWVD and the relative crossing information (RCI methods are used for extracting the feature spectra from the non-stationary vibration signal measured for condition diagnosis. The RCI is used to automatically extract the feature spectrum from the time-frequency distribution of the vibration signal. The extracted feature spectrum is instantaneous, and not correlated with the rotation speed and load. By using the ant colony optimization (ACO clustering algorithm, the synthesizing symptom parameters (SSP for condition diagnosis are obtained. The experimental results shows that the diagnostic sensitivity of the SSP is higher than original symptom parameter (SP, and the SSP can sensitively reflect the characteristics of the feature spectrum for precise condition diagnosis. Finally, a fuzzy diagnosis method based on sequential inference and possibility theory is also proposed, by which the conditions of the machine can be identified sequentially as well.

  6. Comparison of nine DNA extraction methods for the diagnosis of bovine tuberculosis by real time PCR

    OpenAIRE

    Moura, André; Hodon, Mikael Arrais; Soares Filho, Paulo Martins; Issa, Marina de Azevedo; Oliveira, Ana Paula Ferreira de; Fonseca Júnior, Antônio Augusto

    2016-01-01

    ABSTRACT: Bovine tuberculosis is an infectious disease with a high impact on the cattle industry, particularly in developing countries. PCR is a very sensitive method for detection of infectious agents, but the sensitivity of molecular diagnosis is largely dependent on the efficiency of the DNA extraction methods. The objective of this study was to evaluate DNA extraction methods for direct detection of Mycobacterium bovis in bovine tissue. Nine commercial kits for DNA extraction were evalua...

  7. A New Method of PV Array Faults Diagnosis in Smart Grid

    Directory of Open Access Journals (Sweden)

    Ze Cheng

    2014-01-01

    Full Text Available A new fault diagnosis method is proposed for PV arrays with SP connection in this study, the advantages of which are that it would minimize the number of sensors needed and that the accuracy and anti-interference ability are improved with the introduction of fuzzy group decision-making theory. We considered five “decision makers” contributing to the diagnosis of PV array faults, including voltage, current, environmental temperature, panel temperature, and solar illumination. The accuracy and reliability of the proposed method were verified experimentally, and the possible factors contributing to diagnosis deviation were analyzed, based on which solutions were suggested to reduce or eliminate errors in aspects of hardware and software.

  8. Intelligence diagnosis method for roller bearings using features of AE signal

    International Nuclear Information System (INIS)

    Pan, J; Wang, H Q; Wang, F; Yang, J F; Liu, W B

    2012-01-01

    Rolling bearings are important components in rotating machines, which are wildly used in industrial production. The fault diagnosis technology plays a very important role for quality and life of machines. Based on symptom parameters of acoustic emission (AE) signals, this paper presents an intelligent diagnosis method for roller bearings using the principal component analysis, rough sets, and BP neural network to detect faults and distinguish fault types. The principal component analysis and the rough sets algorithm are used to reduce details of time-domain symptom parameters for training the BP neural network. The BP neural network, which is used for condition diagnosis of roller bearings, can obtain good convergence using the symptom parameters acquired by the principal component analysis and the rough sets during learning, and automatically distinguish fault types during diagnosing. Practical examples are provided to verify the efficiency of the proposed method.

  9. Nuclear power plant monitoring and fault diagnosis methods based on the artificial intelligence technique

    International Nuclear Information System (INIS)

    Yoshikawa, S.; Saiki, A.; Ugolini, D.; Ozawa, K.

    1996-01-01

    The main objective of this paper is to develop an advanced diagnosis system based on the artificial intelligence technique to monitor the operation and to improve the operational safety of nuclear power plants. Three different methods have been elaborated in this study: an artificial neural network local diagnosis (NN ds ) scheme that acting at the component level discriminates between normal and abnormal transients, a model-based diagnostic reasoning mechanism that combines a physical causal network model-based knowledge compiler (KC) that generates applicable diagnostic rules from widely accepted physical knowledge compiler (KC) that generates applicable diagnostic rules from widely accepted physical knowledge. Although the three methods have been developed and verified independently, they are highly correlated and, when connected together, form a effective and robust diagnosis and monitoring tool. (authors)

  10. [Molecular diagnostic methods of respiratory infections. Has the scheme diagnosis changed?].

    Science.gov (United States)

    Vila Estapé, Jordi; Zboromyrska, Yuliya; Vergara Gómez, Andrea; Alejo Cancho, Izaskun; Rubio García, Elisa; Álvarez-Martínez, Miriam José; la Bellacasa Brugada, Jorge Puig de; Marcos Maeso, M Ángeles

    2016-07-01

    Lower respiratory tract infections remain one of the most common causes of mortality worldwide, which is why early diagnosis is crucial. Traditionally the microbiological diagnosis of these infections has been based on conventional methods including culture on artificial media for isolation of bacteria and fungi and cell cultures for virus and antibody or antigen detection using antigen-antibody reactions. The main drawback of the above mentioned methods is the time needed for an etiological diagnosis of the infection. The techniques based on molecular biology have drawn much attention in recent decades as tools for rapid diagnosis of infections. Some techniques are very expensive, especially those that can detect various microorganisms in the same reaction, therefore the question that arises is whether the cost of such testing is justified by the information obtained and by the clinical impact that its implementation will determine. In this article we make a review of the various techniques of molecular biology applied to the diagnosis of pneumonia and focus primarily on analysing the impact they may have on the management of patients with acute respiratory tract infections. Copyright © 2016 Elsevier España, S.L.U. All rights reserved.

  11. NN-Es Fault Diagnosis Method in Nuclear Power Equipment Based on Concept Lattice

    International Nuclear Information System (INIS)

    Liu Yongkuo; Xie Chunli; Xia Hong

    2010-01-01

    In order to improve the fault diagnosis accuracy of nuclear power plant,neural network and expert systems were combined to give full play to their advantages. In this paper, the concept lattice was applied to get the object properties, extracting the core attributes, dispensable attributes and relative necessary attributes from a large number raw data of fault symptoms.Based on these attributes, neural networks with different levels of importance were designed to improve the learning speed and diagnosis accuracy, and the diagnosis results of the neural networks were verified by using rule-based reasoning expert system. To verify the accuracy of this method, some simulation experiments about the typical faults of nuclear power plant were conducted. And the simulation results show that it is feasible to diagnose nuclear power plant faults with the confederation diagnosis methods combined the neural networks based on the concept lattice theory and expert system, with the distinctive features such as the efficiency of neural network learning, less calculation and reliability of diagnosis results and so on. (authors)

  12. Assessment of Two Alternative Sample Transport and Fixation Methods in the Microbiological Diagnosis of Bacterial Vaginosis

    Directory of Open Access Journals (Sweden)

    Erica Eason

    2003-01-01

    Full Text Available BACKGROUND: The standard method for specimen collection and transport for microbiological diagnosis of bacterial vaginosis is an air-dried smear of vaginal secretions, promptly heat- or alcohol-fixed, Gram-stained and scored by Nugent's criteria.

  13. Fault diagnosis method based on FFT-RPCA-SVM for Cascaded-Multilevel Inverter.

    Science.gov (United States)

    Wang, Tianzhen; Qi, Jie; Xu, Hao; Wang, Yide; Liu, Lei; Gao, Diju

    2016-01-01

    Thanks to reduced switch stress, high quality of load wave, easy packaging and good extensibility, the cascaded H-bridge multilevel inverter is widely used in wind power system. To guarantee stable operation of system, a new fault diagnosis method, based on Fast Fourier Transform (FFT), Relative Principle Component Analysis (RPCA) and Support Vector Machine (SVM), is proposed for H-bridge multilevel inverter. To avoid the influence of load variation on fault diagnosis, the output voltages of the inverter is chosen as the fault characteristic signals. To shorten the time of diagnosis and improve the diagnostic accuracy, the main features of the fault characteristic signals are extracted by FFT. To further reduce the training time of SVM, the feature vector is reduced based on RPCA that can get a lower dimensional feature space. The fault classifier is constructed via SVM. An experimental prototype of the inverter is built to test the proposed method. Compared to other fault diagnosis methods, the experimental results demonstrate the high accuracy and efficiency of the proposed method. Copyright © 2015 ISA. Published by Elsevier Ltd. All rights reserved.

  14. Method for fault diagnosis of digital control systems in nuclear power plant

    International Nuclear Information System (INIS)

    Suzuki, Satoshi; Nagaoka, Yukio; Ohga, Yukiharu; Ito, Tetsuo

    1990-01-01

    This paper presents a method for localizing faulty components of control systems by replaceable parts such as print boards and cables, in a large scale plant like a nuclear power plant. Most of today's control systems form a distributed configuration including many digital controllers interconnected by data communication networks. Usually, to localize the faulty components in nuclear plant control systems, suspected faulty components are narrowed down by executing manual tests to examine whether the objects are normal or abnormal based on design documents and personnel know-how, besides the uses of self-diagnosis functions built into the control systems. In the present method, procedures of various tests including the know-how and checking of self-diagnosis functions are provided as knowledge of tests. The tests to be executed is determined by considering failure probabilities of objects, and easiness and effectiveness of testing. Then, the suspects are narrowed down sequentially based on the test result. In checking feasibility of this diagnosis method for a simulated control system, intended faults are satisfactorily localized. This method is confirmed to be practicable for diagnosis of large scale digital control systems. (author)

  15. Constitutional reform as process

    OpenAIRE

    Schultze, Rainer-Olaf (Prof.)

    2000-01-01

    Constitutional reform as process. - In: The politics of constitutional reform in North America / Rainer-Olaf Schultze ... (eds.). - Opladen : Leske + Budrich, 2000. - S. 11-31. - (Politikwissenschaftliche paperbacks ; 30)

  16. Transnational Constitutional Law

    NARCIS (Netherlands)

    Zumbansen, P (Peer); K.I. Bhatt (Kinnari)

    2018-01-01

    textabstractThis chapter provides an overview of the emerging field of transnational constitutional law (TCL). Whilst questions of constitutional law are typically discussed in the context of a specific domestic legal setting, a salient strategy of TCL is to understand constitutional law and its

  17. Evaluation of thermal resistance constitution for packaged AlGaN/GaN high electron mobility transistors by structure function method

    International Nuclear Information System (INIS)

    Zhang Guang-Chen; Feng Shi-Wei; Zhou Zhou; Li Jing-Wan; Guo Chun-Sheng

    2011-01-01

    The evaluation of thermal resistance constitution for packaged AlGaN/GaN high electron mobility transistor (HEMT) by structure function method is proposed in this paper. The evaluation is based on the transient heating measurement of the AlGaN/GaN HEMT by pulsed electrical temperature sensitive parameter method. The extracted chip-level and package-level thermal resistances of the packaged multi-finger AlGaN/GaN HEMT with 400-μm SiC substrate are 22.5 K/W and 7.2 K/W respectively, which provides a non-invasive method to evaluate the chip-level thermal resistance of packaged AlGaN/GaN HEMTs. It is also experimentally proved that the extraction of the chip-level thermal resistance by this proposed method is not influenced by package form of the tested device and temperature boundary condition of measurement stage. (condensed matter: electronic structure, electrical, magnetic, and optical properties)

  18. Bioanalytical methods for food allergy diagnosis, allergen detection and new allergen discovery

    OpenAIRE

    Gasilova, Natalia; Girault, Hubert H

    2015-01-01

    For effective monitoring and prevention of the food allergy, one of the emerging health problems nowadays, existing diagnostic procedures and allergen detection techniques are constantly improved. Meanwhile, new methods are also developed, and more and more putative allergens are discovered. This review describes traditional methods and summarizes recent advances in the fast evolving field of the in vitro food allergy diagnosis, allergen detection in food products and discovery of the new all...

  19. Diagnosis of aetiology and complications of relapsing urinary tract infections via imaging methods

    International Nuclear Information System (INIS)

    Rieden, K.; Mende, U.

    1985-01-01

    The indication and efficiency of various radiological examination methods in relapsing infections of the urinary tract, as well as the complications of such infections, are described, and characteristic and pathognomical findings are demonstrated. The diagnostic accuracy of the individual imaging methods depends on the site, size, and density of the pathological process. Accurate diagnosis also requires the incorporation of clinical findings including those established by means of clinical pathology setups. (orig.) [de

  20. Organizational capabilities assessment: a dynamic methodology, methods and a tool for supporting organizational diagnosis

    OpenAIRE

    Rauffet , Philippe; Da Cunha , Catherine ,; Bernard , Alain

    2010-01-01

    Many methods, like CMMI, ISO norms or 5 steps roadmapping, are implemented in organizations in order to develop collective competencies, called also organizational capabilities, around organizational needs. They aim at providing new means to controls resources of organization, and enabling an organizational diagnosis, it is to say the evaluation of the strengths and the weaknesses of the organization. Nevertheless, these methods are generally based on knowledge based models (they are composed...

  1. An Effective Fault Feature Extraction Method for Gas Turbine Generator System Diagnosis

    Directory of Open Access Journals (Sweden)

    Jian-Hua Zhong

    2016-01-01

    Full Text Available Fault diagnosis is very important to maintain the operation of a gas turbine generator system (GTGS in power plants, where any abnormal situations will interrupt the electricity supply. The fault diagnosis of the GTGS faces the main challenge that the acquired data, vibration or sound signals, contain a great deal of redundant information which extends the fault identification time and degrades the diagnostic accuracy. To improve the diagnostic performance in the GTGS, an effective fault feature extraction framework is proposed to solve the problem of the signal disorder and redundant information in the acquired signal. The proposed framework combines feature extraction with a general machine learning method, support vector machine (SVM, to implement an intelligent fault diagnosis. The feature extraction method adopts wavelet packet transform and time-domain statistical features to extract the features of faults from the vibration signal. To further reduce the redundant information in extracted features, kernel principal component analysis is applied in this study. Experimental results indicate that the proposed feature extracted technique is an effective method to extract the useful features of faults, resulting in improvement of the performance of fault diagnosis for the GTGS.

  2. A Fault Alarm and Diagnosis Method Based on Sensitive Parameters and Support Vector Machine

    Science.gov (United States)

    Zhang, Jinjie; Yao, Ziyun; Lv, Zhiquan; Zhu, Qunxiong; Xu, Fengtian; Jiang, Zhinong

    2015-08-01

    Study on the extraction of fault feature and the diagnostic technique of reciprocating compressor is one of the hot research topics in the field of reciprocating machinery fault diagnosis at present. A large number of feature extraction and classification methods have been widely applied in the related research, but the practical fault alarm and the accuracy of diagnosis have not been effectively improved. Developing feature extraction and classification methods to meet the requirements of typical fault alarm and automatic diagnosis in practical engineering is urgent task. The typical mechanical faults of reciprocating compressor are presented in the paper, and the existing data of online monitoring system is used to extract fault feature parameters within 15 types in total; the inner sensitive connection between faults and the feature parameters has been made clear by using the distance evaluation technique, also sensitive characteristic parameters of different faults have been obtained. On this basis, a method based on fault feature parameters and support vector machine (SVM) is developed, which will be applied to practical fault diagnosis. A better ability of early fault warning has been proved by the experiment and the practical fault cases. Automatic classification by using the SVM to the data of fault alarm has obtained better diagnostic accuracy.

  3. Forward chaining method on diagnosis of diseases and pests corn crop

    Science.gov (United States)

    Nurlaeli, Subiyanto

    2017-03-01

    Integrated pest management should be done to control the explosion of plants pest and diseases due to climate change is uncertain. This paper is a present implementation of the forward chaining method in the diagnosis diseases and pests of corn crop to help farmers/agricultural facilitators in getting knowledge about disease and pest corn crop. Forward chaining method as inference engine is used to get a disease/pest that attacks the corn crop based on symptoms. The forward chaining method works based on the fact that there is to get a conclusion. Fact in this system derived from the symptoms of the selected user is matched with the premise on every rule in the knowledge base. A rule that matches the facts to be executed to be the conclusion in the form of diagnosis. This validation using 36 data test, 32 data showed the same diagnostic results between systems with an expert. So, the percentage accuracy of results of diagnosis using data test of 88%. Finally, it can be concluded that the diagnosis system of diseases and pests corn crop can be used to help farmers/agricultural facilitators to diagnose diseases and pests corn crop.

  4. Multi-sensor information fusion method for vibration fault diagnosis of rolling bearing

    Science.gov (United States)

    Jiao, Jing; Yue, Jianhai; Pei, Di

    2017-10-01

    Bearing is a key element in high-speed electric multiple unit (EMU) and any defect of it can cause huge malfunctioning of EMU under high operation speed. This paper presents a new method for bearing fault diagnosis based on least square support vector machine (LS-SVM) in feature-level fusion and Dempster-Shafer (D-S) evidence theory in decision-level fusion which were used to solve the problems about low detection accuracy, difficulty in extracting sensitive characteristics and unstable diagnosis system of single-sensor in rolling bearing fault diagnosis. Wavelet de-nosing technique was used for removing the signal noises. LS-SVM was used to make pattern recognition of the bearing vibration signal, and then fusion process was made according to the D-S evidence theory, so as to realize recognition of bearing fault. The results indicated that the data fusion method improved the performance of the intelligent approach in rolling bearing fault detection significantly. Moreover, the results showed that this method can efficiently improve the accuracy of fault diagnosis.

  5. A multi-method evaluation of a training course on dual diagnosis.

    LENUS (Irish Health Repository)

    Rani, S

    2012-08-01

    A training course on dual diagnosis was developed within the Irish forensic mental health service, to bridge the gap in the lack of training on dual diagnosis in Ireland. The course was designed for service providers within mental health and addiction services. Twenty participants involving nursing, social work, police and social welfare disciplines attended the first training course. A mixed methodology research design was adapted to describe participants\\' evaluation of the training course. Data were collected using multiple methods: pre- and post-test, daily evaluation and focus group interviews. Quantitative data were analysed using the spss Version 16.0 and qualitative data were analysed thematically. Findings from the pre- and post-test suggest an increase in participants\\' knowledge of dual diagnosis and an increase in confidence in conducting groups. Daily evaluation indicates that the course content largely met participants\\' needs. Finally, three themes emerged from the focus group interview: increased confidence, the training course\\/teaching methods and personal\\/organizational challenges. This study implies that service providers within mental health and addiction services benefit from inter-professional, needs and skills based courses incorporating a variety of teaching methods. The way forward for future dual diagnosis training course developments would be working in partnership with service users and carers.

  6. Intelligent Condition Diagnosis Method Based on Adaptive Statistic Test Filter and Diagnostic Bayesian Network.

    Science.gov (United States)

    Li, Ke; Zhang, Qiuju; Wang, Kun; Chen, Peng; Wang, Huaqing

    2016-01-08

    A new fault diagnosis method for rotating machinery based on adaptive statistic test filter (ASTF) and Diagnostic Bayesian Network (DBN) is presented in this paper. ASTF is proposed to obtain weak fault features under background noise, ASTF is based on statistic hypothesis testing in the frequency domain to evaluate similarity between reference signal (noise signal) and original signal, and remove the component of high similarity. The optimal level of significance α is obtained using particle swarm optimization (PSO). To evaluate the performance of the ASTF, evaluation factor Ipq is also defined. In addition, a simulation experiment is designed to verify the effectiveness and robustness of ASTF. A sensitive evaluation method using principal component analysis (PCA) is proposed to evaluate the sensitiveness of symptom parameters (SPs) for condition diagnosis. By this way, the good SPs that have high sensitiveness for condition diagnosis can be selected. A three-layer DBN is developed to identify condition of rotation machinery based on the Bayesian Belief Network (BBN) theory. Condition diagnosis experiment for rolling element bearings demonstrates the effectiveness of the proposed method.

  7. Intelligent Condition Diagnosis Method Based on Adaptive Statistic Test Filter and Diagnostic Bayesian Network

    Directory of Open Access Journals (Sweden)

    Ke Li

    2016-01-01

    Full Text Available A new fault diagnosis method for rotating machinery based on adaptive statistic test filter (ASTF and Diagnostic Bayesian Network (DBN is presented in this paper. ASTF is proposed to obtain weak fault features under background noise, ASTF is based on statistic hypothesis testing in the frequency domain to evaluate similarity between reference signal (noise signal and original signal, and remove the component of high similarity. The optimal level of significance α is obtained using particle swarm optimization (PSO. To evaluate the performance of the ASTF, evaluation factor Ipq is also defined. In addition, a simulation experiment is designed to verify the effectiveness and robustness of ASTF. A sensitive evaluation method using principal component analysis (PCA is proposed to evaluate the sensitiveness of symptom parameters (SPs for condition diagnosis. By this way, the good SPs that have high sensitiveness for condition diagnosis can be selected. A three-layer DBN is developed to identify condition of rotation machinery based on the Bayesian Belief Network (BBN theory. Condition diagnosis experiment for rolling element bearings demonstrates the effectiveness of the proposed method.

  8. Intelligent Condition Diagnosis Method Based on Adaptive Statistic Test Filter and Diagnostic Bayesian Network

    Science.gov (United States)

    Li, Ke; Zhang, Qiuju; Wang, Kun; Chen, Peng; Wang, Huaqing

    2016-01-01

    A new fault diagnosis method for rotating machinery based on adaptive statistic test filter (ASTF) and Diagnostic Bayesian Network (DBN) is presented in this paper. ASTF is proposed to obtain weak fault features under background noise, ASTF is based on statistic hypothesis testing in the frequency domain to evaluate similarity between reference signal (noise signal) and original signal, and remove the component of high similarity. The optimal level of significance α is obtained using particle swarm optimization (PSO). To evaluate the performance of the ASTF, evaluation factor Ipq is also defined. In addition, a simulation experiment is designed to verify the effectiveness and robustness of ASTF. A sensitive evaluation method using principal component analysis (PCA) is proposed to evaluate the sensitiveness of symptom parameters (SPs) for condition diagnosis. By this way, the good SPs that have high sensitiveness for condition diagnosis can be selected. A three-layer DBN is developed to identify condition of rotation machinery based on the Bayesian Belief Network (BBN) theory. Condition diagnosis experiment for rolling element bearings demonstrates the effectiveness of the proposed method. PMID:26761006

  9. Infrared thermography based on artificial intelligence as a screening method for carpal tunnel syndrome diagnosis.

    Science.gov (United States)

    Jesensek Papez, B; Palfy, M; Mertik, M; Turk, Z

    2009-01-01

    This study further evaluated a computer-based infrared thermography (IRT) system, which employs artificial neural networks for the diagnosis of carpal tunnel syndrome (CTS) using a large database of 502 thermal images of the dorsal and palmar side of 132 healthy and 119 pathological hands. It confirmed the hypothesis that the dorsal side of the hand is of greater importance than the palmar side when diagnosing CTS thermographically. Using this method it was possible correctly to classify 72.2% of all hands (healthy and pathological) based on dorsal images and > 80% of hands when only severely affected and healthy hands were considered. Compared with the gold standard electromyographic diagnosis of CTS, IRT cannot be recommended as an adequate diagnostic tool when exact severity level diagnosis is required, however we conclude that IRT could be used as a screening tool for severe cases in populations with high ergonomic risk factors of CTS.

  10. The role of advanced MR methods in the diagnosis of cerebral amyloidoma.

    Science.gov (United States)

    Nossek, Erez; Bashat, Dafna Ben; Artzi, Moran; Rosenberg, Keren; Lichter, Irith; Shtern, Orit; Ami, Haim Ben; Aizenstein, Orna; Vlodavsky, Euvgeni; Constantinescu, Marius; Ram, Zvi

    2009-01-01

    Amyloidoma is a term referring to a tumor-like deposition of extracellular insoluble fibrillar protein. Tumor-like amyloid formation in the brain had been described in isolated cases. However no advanced radiological studies to characterize these lesions have been reported. In the report, we have describe a 59-year-old woman, presented several months prior to diagnosis with memory decline, dizziness, walking instability, and speech difficulties. MRI revealed a left basal ganglia lesion with an intraventricular component. The patient underwent a stereotactic biopsy, which confirmed the diagnosis of amyloidoma, an extensive radiographic characterization of amyloidoma using advanced MR techniques was done, including magnetic resonance spectroscopy, dynamic susceptibility contrast, susceptibility weighted image (SWI), and magnetization transfer (MTR). All advanced MR techniques were able to characterize the amyloidoma as a non-neoplastic process. This is an example where such methods can be used for differential diagnosis of atypical brain lesions.

  11. A fault diagnosis system for PV power station based on global partitioned gradually approximation method

    Science.gov (United States)

    Wang, S.; Zhang, X. N.; Gao, D. D.; Liu, H. X.; Ye, J.; Li, L. R.

    2016-08-01

    As the solar photovoltaic (PV) power is applied extensively, more attentions are paid to the maintenance and fault diagnosis of PV power plants. Based on analysis of the structure of PV power station, the global partitioned gradually approximation method is proposed as a fault diagnosis algorithm to determine and locate the fault of PV panels. The PV array is divided into 16x16 blocks and numbered. On the basis of modularly processing of the PV array, the current values of each block are analyzed. The mean current value of each block is used for calculating the fault weigh factor. The fault threshold is defined to determine the fault, and the shade is considered to reduce the probability of misjudgments. A fault diagnosis system is designed and implemented with LabVIEW. And it has some functions including the data realtime display, online check, statistics, real-time prediction and fault diagnosis. Through the data from PV plants, the algorithm is verified. The results show that the fault diagnosis results are accurate, and the system works well. The validity and the possibility of the system are verified by the results as well. The developed system will be benefit for the maintenance and management of large scale PV array.

  12. A Novel Mittag-Leffler Kernel Based Hybrid Fault Diagnosis Method for Wheeled Robot Driving System

    Directory of Open Access Journals (Sweden)

    Xianfeng Yuan

    2015-01-01

    presents a novel hybrid fault diagnosis framework based on Mittag-Leffler kernel (ML-kernel support vector machine (SVM and Dempster-Shafer (D-S fusion. Using sensor data sampled under different running conditions, the proposed approach initially establishes multiple principal component analysis (PCA models for fault feature extraction. The fault feature vectors are then applied to train the probabilistic SVM (PSVM classifiers that arrive at a preliminary fault diagnosis. To improve the accuracy of preliminary results, a novel ML-kernel based PSVM classifier is proposed in this paper, and the positive definiteness of the ML-kernel is proved as well. The basic probability assignments (BPAs are defined based on the preliminary fault diagnosis results and their confidence values. Eventually, the final fault diagnosis result is archived by the fusion of the BPAs. Experimental results show that the proposed framework not only is capable of detecting and identifying the faults in the robot driving system, but also has better performance in stability and diagnosis accuracy compared with the traditional methods.

  13. Diagnosis of porcine enzootic pneumonia by post mortem sanitary inspection: comparison with other diagnostic methods

    Directory of Open Access Journals (Sweden)

    Kênia de Fátima Carrijo

    2014-06-01

    Full Text Available ABSTRACT. Carrijo K.F., Nascimento E.R., Pereira V.L.A., Morés N., Klein, C.S., Domingues L.M. & Tortelly R. [Diagnosis of porcine enzootic pneumonia by post mortem sanitary inspection: comparison with other diagnostic methods.] Diagnóstico da pneumonia enzoótica suína pela inspeção sanitária post mortem: comparação com outros métodos de diagnóstico. Revista Brasileira de Veterinária Brasileira 36(2:188-194, 2014. Faculdade de Medicina Veterinária, Universidade Federal de Uberlândia, Av. Pará, 1720, Bloco 2T, Jardim Umuarama, Uberlândia, MG 38400-902, Brasil. E-mail: keniacarrijo@ famev.ufu.br To compare the concordance of the diagnosis of porcine enzootic pneumonia (PEP by post-mortem Sanitary Inspection with other methods (histophatology and immunohistochemistry - IHC, were used lung tissue samples from 100 pigs slaughtered under sanitary inspection, and 50 of these had macroscopic lesions suggestive of PEP and 50 had no such lesions. These were fixed in 10% buffered formalin and processed by routine procedures for paraffin embedding and IHC technique for Mycoplasma hyopneumoniae using a monoespecific polyclonal antibody. The study demonstrating that there is concordance between the diagnosis of Sanitary Inspection with histophatology, between the diagnosis of Sanitary Inspection with IHC and histophatology with IHC. It can be conclude that when the lung has gross lesions of PEP, the probability the result is positive to M. hyopneumoniae by IHC and the presence of microscopic lesions increases. Thus, the microscopic diagnosis for PEP is feasible because it is associated to the other, so that the diagnosis given by the officials of Sanitary Inspection in slaughterhouses is not wrong; the macroscopic diagnosis is therefore a valid method for the diagnosis of PEP, it being understood this is not to say that the detection of M. hyopneumoniae.

  14. UNDERSTANDING INFORMAL CONSTITUTIONAL CHANGE

    Directory of Open Access Journals (Sweden)

    Stephen M. Griffin

    2016-01-01

    Full Text Available Amid much recent American work on the problem of informal constitutional change, this article stakes out a distinctive position. I argue that theories of constitutional change in the US must address the question of the relationship between the “small c” and “big C” Constitution and treat seriously the possibility of conflict between them. I stress the unavoidable role the text of the Constitution and structural doctrines of federalism and separation of powers play in this relationship and thus in constitutional change, both formal and informal. I therefore counsel against theories that rely solely on a practice-based approach or analogies between “small c” constitutional developments and British or Commonwealth traditions of the “unwritten” constitution and constitutional “conventions.” The alternative I advocate is to approach constitutional change from a historicist perspective that focuses attention on state building and the creation of new institutional capacities. This approach will allow us to make progress by highlighting that there can be multiple constitutional orders in a given historical era, thus accounting for the conflictual nature of contemporary constitutional development in the US.

  15. Bioanalytical methods for food allergy diagnosis, allergen detection and new allergen discovery.

    Science.gov (United States)

    Gasilova, Natalia; Girault, Hubert H

    2015-01-01

    For effective monitoring and prevention of the food allergy, one of the emerging health problems nowadays, existing diagnostic procedures and allergen detection techniques are constantly improved. Meanwhile, new methods are also developed, and more and more putative allergens are discovered. This review describes traditional methods and summarizes recent advances in the fast evolving field of the in vitro food allergy diagnosis, allergen detection in food products and discovery of the new allergenic molecules. A special attention is paid to the new diagnostic methods under laboratory development like various immuno- and aptamer-based assays, including immunoaffinity capillary electrophoresis. The latter technique shows the importance of MS application not only for the allergen detection but also for the allergy diagnosis.

  16. CORRELATIONS BETWEEN CONTEMPORARY METHODS IN THE DIAGNOSIS OF CHLAMYDIA TRACHOMATIS UROGENITAL INFECTIONS.

    Directory of Open Access Journals (Sweden)

    Ilko Bakardzhiev

    2011-10-01

    Full Text Available The subject of this study were 486 outpatients between the ages of 17 and 62, diagnosed with urethritis, epidydimitis, prostatitis, cervicitis, endocervicitis, pelvic inflammatory disease and sterility. The following tests were used to make the diagnosis of Chlamydia trachomatis: Enzyme Immunoassay (EIA, Enzyme-Linked Fluorescent Assay (ELFA, Polymerase Chain Reaction DNA amplification for Chlamydia Trachomatis, Neisseria Gonorrhoeae, Mycoplasma Genitalium and Ureaplasma Urealyiticum. Comparison PCR and EIA showed statistically significant difference between the positive results obtained by the two methods (p0,1. EIA is a method that gives a higher percentage of nonspecific positive reactions, while the results obtained from ELFA are much closer to the ones obtained by PCR. According to contemporary evidence based medicine, the developmet of unified standard methods for diagnosis and evaluation is of vital importance, not only for the patient and the treating physician but also concerns for the healthcare system, the general public and the pharmaceutical companies as well.

  17. Comparison of the Sensitivity of Three Methods for the Early Diagnosis of Sporotrichosis in Cats.

    Science.gov (United States)

    Silva, J N; Miranda, L H M; Menezes, R C; Gremião, I D F; Oliveira, R V C; Vieira, S M M; Conceição-Silva, F; Ferreiro, L; Pereira, S A

    2018-04-01

    Sporotrichosis is caused by species of fungi within the Sporothrix schenckii complex that infect man and animals. In Rio de Janeiro, Brazil, an epidemic has been observed since 1998, with most of the cases being related to transmission from infected cats. Although the definitive diagnosis of feline sporotrichosis is made by fungal culture, cytopathological and histopathological examinations are used routinely, because the long culture period may delay treatment onset. However, alternative methods are desirable in cases of low fungal burden. Immunohistochemistry (IHC) has been described as a sensitive method for diagnosing human and canine sporotrichosis, but there are no reports of its application to cats. The aim of this study was to analyse the sensitivity of cytopathological examination (Quick Panoptic method), histopathology (Grocott silver stain) and anti-Sporothrix IHC by blinded comparisons, using fungal culture as the reference standard. Samples were collected from 184 cats with sporotrichosis that exhibited skin ulcers. The sensitivities of Grocott silver stain, cytopathological examination and IHC were 91.3%, 87.0% and 88.6%, respectively. Grocott silver stain showed the best performance. IHC showed high sensitivity, as did cytopathological examination and these may be considered as alternative methodologies. When the three methods were combined, the diagnosis was established in 180 (97.8%) out of 184 cases. Taken together, these findings indicate the need to implement these methods as routine tools for the early diagnosis of sporotrichosis in cats, notably when fungal culture is not available. Copyright © 2018 Elsevier Ltd. All rights reserved.

  18. A survey on constitutional justice

    Directory of Open Access Journals (Sweden)

    Kheirollah Parvin

    2015-05-01

    Full Text Available The idea of supervising the conformity of statutory law with constitutional law, is due to necessities rooted in two essential principles: the supremacy of constitution and the hierarchy of the law. Constitution as the supreme law in the sense of status and legal value , is placed at the top of the legal pyramid of every political system and therefore requires a special organization and discipline that will act as the sanction of the principles and the main content incorporated in this legal instrument. this special organization and discipline known as Constitutional justice in legal Literature now and have studing in two main patterns. Firs pattern based on Supervision of courts on rules and other pattern is Apply by Emphasis on role of Political Institutions in Supervision on rules. This two patterns have common purpose but have different backgrounds and methods.

  19. Development of in-house serological methods for diagnosis and surveillance of chikungunya

    Directory of Open Access Journals (Sweden)

    Saira Saborío Galo

    2017-08-01

    Full Text Available ABSTRACT Objective To develop and evaluate serological methods for chikungunya diagnosis and research in Nicaragua. Methods Two IgM ELISA capture systems (MAC-ELISA for diagnosis of acute chikungunya virus (CHIKV infections, and two Inhibition ELISA Methods (IEM to measure total antibodies against CHIKV were developed using monoclonal antibodies (mAbs and hyperimmune serum at the National Virology Laboratory of Nicaragua in 2014–2015. The sensitivity, specificity, predictive values, and agreement of the MAC-ELISAs were obtained by comparing the results of 198 samples (116 positive; 82 negative with the Centers for Disease Control and Prevention’s IgM ELISA (Atlanta, Georgia, United States; CDC-MAC-ELISA. For clinical evaluation of the four serological techniques, 260 paired acute and convalescent phase serum samples of suspected chikungunya cases were used. Results All four assays were standardized by determining the optimal concentrations of the different reagents. Processing times were substantially reduced compared to the CDC-MAC-ELISA. For the MAC-ELISA systems, a sensitivity of 96.6% and 97.4%, and a specificity of 98.8% and 91.5% were obtained using mAb and hyperimmune serum, respectively, compared with the CDC method. Clinical evaluation of the four serological techniques versus the CDC real-time RT-PCR assay resulted in a sensitivity of 95.7% and a specificity of 88.8%–95.9%. Conclusion Two MAC-ELISA and two IEM systems were standardized, demonstrating very good quality for chikungunya diagnosis and research demands. This will achieve more efficient epidemiological surveillance in Nicaragua, the first country in Central America to produce its own reagents for serological diagnosis of CHIKV. The methods evaluated here can be applied in other countries and will contribute to sustainable diagnostic systems to combat the disease.

  20. A Novel Bearing Fault Diagnosis Method Based on Gaussian Restricted Boltzmann Machine

    Directory of Open Access Journals (Sweden)

    Xiao-hui He

    2016-01-01

    Full Text Available To realize the fault diagnosis of bearing effectively, this paper presents a novel bearing fault diagnosis method based on Gaussian restricted Boltzmann machine (Gaussian RBM. Vibration signals are firstly resampled to the same equivalent speed. Subsequently, the envelope spectrums of the resampled data are used directly as the feature vectors to represent the fault types of bearing. Finally, in order to deal with the high-dimensional feature vectors based on envelope spectrum, a classifier model based on Gaussian RBM is applied. Gaussian RBM has the ability to provide a closed-form representation of the distribution underlying the training data, and it is very convenient for modeling high-dimensional real-valued data. Experiments on 10 different data sets verify the performance of the proposed method. The superiority of Gaussian RBM classifier is also confirmed by comparing with other classifiers, such as extreme learning machine, support vector machine, and deep belief network. The robustness of the proposed method is also studied in this paper. It can be concluded that the proposed method can realize the bearing fault diagnosis accurately and effectively.

  1. A new method of CT scanning for the diagnosis of mandibular fractures; A preliminary report: diagnosis of condyle fractures

    Energy Technology Data Exchange (ETDEWEB)

    Tsukagoshi, Taku; Satoh, Kaneshige; Onizuka, Takuya (Showa Univ., Tokyo (Japan). School of Medicine)

    1990-08-01

    The condylar neck of the mandible is one of the most common fracture sites in the facial skeleton. Such a fracture is routinely diagnosed by A-P, lateral oblique, and Towne projection roentgenography or orthopantomography. Despite the combination of these films, fracture of the neck of the mandible is still difficult to diagnose definitely. Therefore, a new CT scanning method was developed for diagnosing fractures of the neck of the condylar mandible. The CT axis is projected along the length of the mandible, extending from the condyle to the symphysis. This projection visualizes both the condyle and the mandibular symphysis in the same plane. The patient is placed in a supine position with the head fully extended. The base line, a line extending from the midpoint of the glenoid fossa to the menton, is determined with a lateral facial cephalogram. CT scanning with a 5 mm window is performed in parallel with and 2 cm anterior to and 2 cm posterior to the base line. When CT scanning was performed in a healthy volunteer, the condition of the condyle and the condylar neck of the mandible was clearly shown, and the view extended from the condyle to the symphysis. For automobile accident patients in whom fracture of the neck of the mandible was associated with fracture of the symphysis, two fractures were found in the same plane. A newly developed CT scanning technique is useful in the diagnosis of fractures of the condylar neck of the mandible and in the identification of fractures at other mandibular sites. It also allows scanning of patients in a supine position, which may aid in managing patients with multiple traumas. (N.K.).

  2. Comparison between Two Methods for Diagnosis of Trichinellosis: Trichinoscopy and Artificial Digestion

    Directory of Open Access Journals (Sweden)

    María Laura Vignau

    1997-09-01

    Full Text Available Two direct methods for the diagnosis of trichinellosis were compared: trichinoscopy and artificial digestion. Muscles from 17 wistar rats, orally infected with 500 Trichinella spiralis encysted larvae were examined. From each of the following muscles: diaphragm, tongue, masseters, intercostals, triceps brachialis and cuadriceps femoralis, 648,440 larvae from 1 g samples were recovered. The linear correlation between trichinoscopy and artificial digestion was very high and significant (r=0.94, p< 0.0001, showing that both methods for the detection of muscular larvae did not differ significantly. In both methods, significant differences were found in the distribution of larvae per gramme of muscle

  3. Constitutive models in LAME.

    Energy Technology Data Exchange (ETDEWEB)

    Hammerand, Daniel Carl; Scherzinger, William Mark

    2007-09-01

    The Library of Advanced Materials for Engineering (LAME) provides a common repository for constitutive models that can be used in computational solid mechanics codes. A number of models including both hypoelastic (rate) and hyperelastic (total strain) constitutive forms have been implemented in LAME. The structure and testing of LAME is described in Scherzinger and Hammerand ([3] and [4]). The purpose of the present report is to describe the material models which have already been implemented into LAME. The descriptions are designed to give useful information to both analysts and code developers. Thus far, 33 non-ITAR/non-CRADA protected material models have been incorporated. These include everything from the simple isotropic linear elastic models to a number of elastic-plastic models for metals to models for honeycomb, foams, potting epoxies and rubber. A complete description of each model is outside the scope of the current report. Rather, the aim here is to delineate the properties, state variables, functions, and methods for each model. However, a brief description of some of the constitutive details is provided for a number of the material models. Where appropriate, the SAND reports available for each model have been cited. Many models have state variable aliases for some or all of their state variables. These alias names can be used for outputting desired quantities. The state variable aliases available for results output have been listed in this report. However, not all models use these aliases. For those models, no state variable names are listed. Nevertheless, the number of state variables employed by each model is always given. Currently, there are four possible functions for a material model. This report lists which of these four methods are employed in each material model. As far as analysts are concerned, this information is included only for the awareness purposes. The analyst can take confidence in the fact that model has been properly implemented

  4. A Method of Rotating Machinery Fault Diagnosis Based on the Close Degree of Information Entropy

    Institute of Scientific and Technical Information of China (English)

    GENG Jun-bao; HUANG Shu-hong; JIN Jia-shan; CHEN Fei; LIU Wei

    2006-01-01

    This paper presents a method of rotating machinery fault diagnosis based on the close degree of information entropy. In the view of the information entropy, we introduce four information entropy features of the rotating machinery, which describe the vibration condition of the machinery. The four features are, respectively, denominated as singular spectrum entropy, power spectrum entropy, wavelet space state feature entropy and wavelet power spectrum entropy. The value scopes of the four information entropy features of the rotating machinery in some typical fault conditions are gained by experiments, which can be acted as the standard features of fault diagnosis. According to the principle of the shorter distance between the more similar models, the decision-making method based on the close degree of information entropy is put forward to deal with the recognition of fault patterns. We demonstrate the effectiveness of this approach in an instance involving the fault pattern recognition of some rotating machinery.

  5. Development of failure diagnosis method based on transient information of nuclear power plant

    International Nuclear Information System (INIS)

    Washio, Takashi; Kitamura, Masaharu; Sugiyama, Kazusuke

    1987-01-01

    This paper proposes a new method of failure diagnosis of nuclear power plant (NPP). Transient behavior of the NPP includes ample failure information even for a limited period of time from the failure onset. We tried to develop a diagnosis system with high capability of identifying the failure cause and of estimating failure severeness. The Walsh function transformation of transient time series data and the reduction of the Walsh coefficients into ternary valued amplitude indicators were utilized to extract the essential characteristics of failure. The correspondences of the transient characteristics and causes were summarized in a failure symptom database. A method of ternary tree search using an information measure as a heuristic strategy was adopted to conduct the efficient retrieval of failure causes in the database. Through numerical experiments using a simulation model of a NPP, the diagnostic capability of the system was proved to be satisfactory. (author)

  6. A novel diagnosis method for a Hall plates-based rotary encoder with a magnetic concentrator.

    Science.gov (United States)

    Meng, Bumin; Wang, Yaonan; Sun, Wei; Yuan, Xiaofang

    2014-07-31

    In the last few years, rotary encoders based on two-dimensional complementary metal oxide semiconductors (CMOS) Hall plates with a magnetic concentrator have been developed to measure contactless absolute angle. There are various error factors influencing the measuring accuracy, which are difficult to locate after the assembly of encoder. In this paper, a model-based rapid diagnosis method is presented. Based on an analysis of the error mechanism, an error model is built to compare minimum residual angle error and to quantify the error factors. Additionally, a modified particle swarm optimization (PSO) algorithm is used to reduce the calculated amount. The simulation and experimental results show that this diagnosis method is feasible to quantify the causes of the error and to reduce iteration significantly.

  7. Fault Diagnosis Method Based on Information Entropy and Relative Principal Component Analysis

    Directory of Open Access Journals (Sweden)

    Xiaoming Xu

    2017-01-01

    Full Text Available In traditional principle component analysis (PCA, because of the neglect of the dimensions influence between different variables in the system, the selected principal components (PCs often fail to be representative. While the relative transformation PCA is able to solve the above problem, it is not easy to calculate the weight for each characteristic variable. In order to solve it, this paper proposes a kind of fault diagnosis method based on information entropy and Relative Principle Component Analysis. Firstly, the algorithm calculates the information entropy for each characteristic variable in the original dataset based on the information gain algorithm. Secondly, it standardizes every variable’s dimension in the dataset. And, then, according to the information entropy, it allocates the weight for each standardized characteristic variable. Finally, it utilizes the relative-principal-components model established for fault diagnosis. Furthermore, the simulation experiments based on Tennessee Eastman process and Wine datasets demonstrate the feasibility and effectiveness of the new method.

  8. Diagnosis of human malignancies using laser-induced breakdown spectroscopy in combination with chemometric methods

    Science.gov (United States)

    Chen, Xue; Li, Xiaohui; Yu, Xin; Chen, Deying; Liu, Aichun

    2018-01-01

    Diagnosis of malignancies is a challenging clinical issue. In this work, we present quick and robust diagnosis and discrimination of lymphoma and multiple myeloma (MM) using laser-induced breakdown spectroscopy (LIBS) conducted on human serum samples, in combination with chemometric methods. The serum samples collected from lymphoma and MM cancer patients and healthy controls were deposited on filter papers and ablated with a pulsed 1064 nm Nd:YAG laser. 24 atomic lines of Ca, Na, K, H, O, and N were selected for malignancy diagnosis. Principal component analysis (PCA), linear discriminant analysis (LDA), quadratic discriminant analysis (QDA), and k nearest neighbors (kNN) classification were applied to build the malignancy diagnosis and discrimination models. The performances of the models were evaluated using 10-fold cross validation. The discrimination accuracy, confusion matrix and receiver operating characteristic (ROC) curves were obtained. The values of area under the ROC curve (AUC), sensitivity and specificity at the cut-points were determined. The kNN model exhibits the best performances with overall discrimination accuracy of 96.0%. Distinct discrimination between malignancies and healthy controls has been achieved with AUC, sensitivity and specificity for healthy controls all approaching 1. For lymphoma, the best discrimination performance values are AUC = 0.990, sensitivity = 0.970 and specificity = 0.956. For MM, the corresponding values are AUC = 0.986, sensitivity = 0.892 and specificity = 0.994. The results show that the serum-LIBS technique can serve as a quick, less invasive and robust method for diagnosis and discrimination of human malignancies.

  9. Transnational Constitutional Law

    OpenAIRE

    Zumbansen, P (Peer); Bhatt, Kinnari

    2018-01-01

    textabstractThis chapter provides an overview of the emerging field of transnational constitutional law (TCL). Whilst questions of constitutional law are typically discussed in the context of a specific domestic legal setting, a salient strategy of TCL is to understand constitutional law and its values by placing them ‘in context’ with existing and evolving cultural norms and political, social and economic discourses and struggles. Drawing on socio-legal investigations into the relationships ...

  10. [Accuracy of three methods for the rapid diagnosis of oral candidiasis].

    Science.gov (United States)

    Lyu, X; Zhao, C; Yan, Z M; Hua, H

    2016-10-09

    Objective: To explore a simple, rapid and efficient method for the diagnosis of oral candidiasis in clinical practice. Methods: Totally 124 consecutive patients with suspected oral candidiasis were enrolled from Department of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing, China. Exfoliated cells of oral mucosa and saliva or concentrated oral rinse) obtained from all participants were tested by three rapid smear methods(10% KOH smear, gram-stained smear, Congo red stained smear). The diagnostic efficacy(sensitivity, specificity, Youden's index, likelihood ratio, consistency, predictive value and area under curve(AUC) of each of the above mentioned three methods was assessed by comparing the results with the gold standard(combination of clinical diagnosis, laboratory diagnosis and expert opinion). Results: Gram-stained smear of saliva(or concentrated oral rinse) demonstrated highest sensitivity(82.3%). Test of 10%KOH smear of exfoliated cells showed highest specificity(93.5%). Congo red stained smear of saliva(or concentrated oral rinse) displayed highest diagnostic efficacy(79.0% sensitivity, 80.6% specificity, 0.60 Youden's index, 4.08 positive likelihood ratio, 0.26 negative likelihood ratio, 80% consistency, 80.3% positive predictive value, 79.4% negative predictive value and 0.80 AUC). Conclusions: Test of Congo red stained smear of saliva(or concentrated oral rinse) could be used as a point-of-care tool for the rapid diagnosis of oral candidiasis in clinical practice. Trial registration: Chinese Clinical Trial Registry, ChiCTR-DDD-16008118.

  11. Nonparametric Change Point Diagnosis Method of Concrete Dam Crack Behavior Abnormality

    OpenAIRE

    Li, Zhanchao; Gu, Chongshi; Wu, Zhongru

    2013-01-01

    The study on diagnosis method of concrete crack behavior abnormality has always been a hot spot and difficulty in the safety monitoring field of hydraulic structure. Based on the performance of concrete dam crack behavior abnormality in parametric statistical model and nonparametric statistical model, the internal relation between concrete dam crack behavior abnormality and statistical change point theory is deeply analyzed from the model structure instability of parametric statistical model ...

  12. A Novel Data Hierarchical Fusion Method for Gas Turbine Engine Performance Fault Diagnosis

    Directory of Open Access Journals (Sweden)

    Feng Lu

    2016-10-01

    Full Text Available Gas path fault diagnosis involves the effective utilization of condition-based sensor signals along engine gas path to accurately identify engine performance failure. The rapid development of information processing technology has led to the use of multiple-source information fusion for fault diagnostics. Numerous efforts have been paid to develop data-based fusion methods, such as neural networks fusion, while little research has focused on fusion architecture or the fusion of different method kinds. In this paper, a data hierarchical fusion using improved weighted Dempster–Shaffer evidence theory (WDS is proposed, and the integration of data-based and model-based methods is presented for engine gas-path fault diagnosis. For the purpose of simplifying learning machine typology, a recursive reduced kernel based extreme learning machine (RR-KELM is developed to produce the fault probability, which is considered as the data-based evidence. Meanwhile, the model-based evidence is achieved using particle filter-fuzzy logic algorithm (PF-FL by engine health estimation and component fault location in feature level. The outputs of two evidences are integrated using WDS evidence theory in decision level to reach a final recognition decision of gas-path fault pattern. The characteristics and advantages of two evidences are analyzed and used as guidelines for data hierarchical fusion framework. Our goal is that the proposed methodology provides much better performance of gas-path fault diagnosis compared to solely relying on data-based or model-based method. The hierarchical fusion framework is evaluated in terms to fault diagnosis accuracy and robustness through a case study involving fault mode dataset of a turbofan engine that is generated by the general gas turbine simulation. These applications confirm the effectiveness and usefulness of the proposed approach.

  13. Development of in-house serological methods for diagnosis and surveillance of chikungunya.

    Science.gov (United States)

    Galo, Saira Saborío; González, Karla; Téllez, Yolanda; García, Nadezna; Pérez, Leonel; Gresh, Lionel; Harris, Eva; Balmaseda, Ángel

    2017-08-21

    To develop and evaluate serological methods for chikungunya diagnosis and research in Nicaragua. Two IgM ELISA capture systems (MAC-ELISA) for diagnosis of acute chikungunya virus (CHIKV) infections, and two Inhibition ELISA Methods (IEM) to measure total antibodies against CHIKV were developed using monoclonal antibodies (mAbs) and hyperimmune serum at the National Virology Laboratory of Nicaragua in 2014-2015. The sensitivity, specificity, predictive values, and agreement of the MAC-ELISAs were obtained by comparing the results of 198 samples (116 positive; 82 negative) with the Centers for Disease Control and Prevention's IgM ELISA (Atlanta, Georgia, United States; CDC-MAC-ELISA). For clinical evaluation of the four serological techniques, 260 paired acute and convalescent phase serum samples of suspected chikungunya cases were used. All four assays were standardized by determining the optimal concentrations of the different reagents. Processing times were substantially reduced compared to the CDC-MAC-ELISA. For the MAC-ELISA systems, a sensitivity of 96.6% and 97.4%, and a specificity of 98.8% and 91.5% were obtained using mAb and hyperimmune serum, respectively, compared with the CDC method. Clinical evaluation of the four serological techniques versus the CDC real-time RT-PCR assay resulted in a sensitivity of 95.7% and a specificity of 88.8%-95.9%. Two MAC-ELISA and two IEM systems were standardized, demonstrating very good quality for chikungunya diagnosis and research demands. This will achieve more efficient epidemiological surveillance in Nicaragua, the first country in Central America to produce its own reagents for serological diagnosis of CHIKV. The methods evaluated here can be applied in other countries and will contribute to sustainable diagnostic systems to combat the disease.

  14. [Application of optimized parameters SVM based on photoacoustic spectroscopy method in fault diagnosis of power transformer].

    Science.gov (United States)

    Zhang, Yu-xin; Cheng, Zhi-feng; Xu, Zheng-ping; Bai, Jing

    2015-01-01

    In order to solve the problems such as complex operation, consumption for the carrier gas and long test period in traditional power transformer fault diagnosis approach based on dissolved gas analysis (DGA), this paper proposes a new method which is detecting 5 types of characteristic gas content in transformer oil such as CH4, C2H2, C2H4, C2H6 and H2 based on photoacoustic Spectroscopy and C2H2/C2H4, CH4/H2, C2H4/C2H6 three-ratios data are calculated. The support vector machine model was constructed using cross validation method under five support vector machine functions and four kernel functions, heuristic algorithms were used in parameter optimization for penalty factor c and g, which to establish the best SVM model for the highest fault diagnosis accuracy and the fast computing speed. Particles swarm optimization and genetic algorithm two types of heuristic algorithms were comparative studied in this paper for accuracy and speed in optimization. The simulation result shows that SVM model composed of C-SVC, RBF kernel functions and genetic algorithm obtain 97. 5% accuracy in test sample set and 98. 333 3% accuracy in train sample set, and genetic algorithm was about two times faster than particles swarm optimization in computing speed. The methods described in this paper has many advantages such as simple operation, non-contact measurement, no consumption for the carrier gas, long test period, high stability and sensitivity, the result shows that the methods described in this paper can instead of the traditional transformer fault diagnosis by gas chromatography and meets the actual project needs in transformer fault diagnosis.

  15. Advantages in diagnosis of coronary artery disease by a combination of nuclear medicine methods

    International Nuclear Information System (INIS)

    Schmidt, H.A.E.; Birk, W.; Michele, E.

    1983-01-01

    Investigations on 106 patients with coronary artery disease were performed to improve the diagnosis of myocardial ischemia by combining myocardial scintigraphy and gated blood pool studies. The results show that it is possible to enhance the detection of coronary artery and to classify haemodynamic efficiency. In addition we found that in investigations performed on patients with arrhytmia and under stress conditions the 'hybrid-technique' is superior to the framemode acquisition method. (orig.) [de

  16. Methods of formation of the knowledge base in the diagnosis of melanoma

    International Nuclear Information System (INIS)

    Selchuk, V Y; Rodionova, O V; Sukhova, O G; Polyakov, E V; Grebennikova, O P; Burov, D A; Emelianova, G S

    2017-01-01

    The method of building of information systems for the diagnosis of skin melanoma is described in the presented work. Malignant tumors at the level of macro - and microimages in combination with clinical data are investigated. The development is made with the use of MySQL. An information system is a result of joint activities of the National research nuclear University “MEPhI” (Moscow Engineering Physics Institute) with N. N. Blokhin Russian Cancer Scientific Center. (paper)

  17. Fault Diagnosis Method of Polymerization Kettle Equipment Based on Rough Sets and BP Neural Network

    Directory of Open Access Journals (Sweden)

    Shu-zhi Gao

    2013-01-01

    Full Text Available Polyvinyl chloride (PVC polymerizing production process is a typical complex controlled object, with complexity features, such as nonlinear, multivariable, strong coupling, and large time-delay. Aiming at the real-time fault diagnosis and optimized monitoring requirements of the large-scale key polymerization equipment of PVC production process, a real-time fault diagnosis strategy is proposed based on rough sets theory with the improved discernibility matrix and BP neural networks. The improved discernibility matrix is adopted to reduct the attributes of rough sets in order to decrease the input dimensionality of fault characteristics effectively. Levenberg-Marquardt BP neural network is trained to diagnose the polymerize faults according to the reducted decision table, which realizes the nonlinear mapping from fault symptom set to polymerize fault set. Simulation experiments are carried out combining with the industry history datum to show the effectiveness of the proposed rough set neural networks fault diagnosis method. The proposed strategy greatly increased the accuracy rate and efficiency of the polymerization fault diagnosis system.

  18. What Is the Best NGS Enrichment Method for the Molecular Diagnosis of Monogenic Diabetes and Obesity?

    Directory of Open Access Journals (Sweden)

    Julien Philippe

    Full Text Available Molecular diagnosis of monogenic diabetes and obesity is of paramount importance for both the patient and society, as it can result in personalized medicine associated with a better life and it eventually saves health care spending. Genetic clinical laboratories are currently switching from Sanger sequencing to next-generation sequencing (NGS approaches but choosing the optimal protocols is not easy. Here, we compared the sequencing coverage of 43 genes involved in monogenic forms of diabetes and obesity, and variant detection rates, resulting from four enrichment methods based on the sonication of DNA (Agilent SureSelect, RainDance technologies, or using enzymes for DNA fragmentation (Illumina Nextera, Agilent HaloPlex. We analyzed coding exons and untranslated regions of the 43 genes involved in monogenic diabetes and obesity. We found that none of the methods achieves yet full sequencing of the gene targets. Nonetheless, the RainDance, SureSelect and HaloPlex enrichment methods led to the best sequencing coverage of the targets; while the Nextera method resulted in the poorest sequencing coverage. Although the sequencing coverage was high, we unexpectedly found that the HaloPlex method missed 20% of variants detected by the three other methods and Nextera missed 10%. The question of which NGS technique for genetic diagnosis yields the highest diagnosis rate is frequently discussed in the literature and the response is still unclear. Here, we showed that the RainDance enrichment method as well as SureSelect, which are both based on the sonication of DNA, resulted in a good sequencing quality and variant detection, while the use of enzymes to fragment DNA (HaloPlex or Nextera might not be the best strategy to get an accurate sequencing.

  19. An Improved Method Based on CEEMD for Fault Diagnosis of Rolling Bearing

    Directory of Open Access Journals (Sweden)

    Meijiao Li

    2014-11-01

    Full Text Available In order to improve the effectiveness for identifying rolling bearing faults at an early stage, the present paper proposed a method that combined the so-called complementary ensemble empirical mode decomposition (CEEMD method with a correlation theory for fault diagnosis of rolling element bearing. The cross-correlation coefficient between the original signal and each intrinsic mode function (IMF was calculated in order to reduce noise and select an effective IMF. Using the present method, a rolling bearing fault experiment with vibration signals measured by acceleration sensors was carried out, and bearing inner race and outer race defect at a varying rotating speed with different degrees of defect were analyzed. And the proposed method was compared with several algorithms of empirical mode decomposition (EMD to verify its effectiveness. Experimental results showed that the proposed method was available for detecting the bearing faults and able to detect the fault at an early stage. It has higher computational efficiency and is capable of overcoming modal mixing and aliasing. Therefore, the proposed method is more suitable for rolling bearing diagnosis.

  20. Fault Diagnosis of Rotating Machinery Based on the Multiscale Local Projection Method and Diagonal Slice Spectrum

    Directory of Open Access Journals (Sweden)

    Yong Lv

    2018-04-01

    Full Text Available The vibration signals of bearings and gears measured from rotating machinery usually have nonlinear, nonstationary characteristics. The local projection algorithm cannot only reduce the noise of the nonlinear system, but can also preserve the nonlinear deterministic structure of the signal. The influence of centroid selection on the performance of noise reduction methods is analyzed, and the multiscale local projection method of centroid was proposed in this paper. This method considers both the geometrical shape and statistical error of the signal in high dimensional phase space, which can effectively eliminate the noise and preserve the complete geometric structure of the attractors. The diagonal slice spectrum can identify the frequency components of quadratic phase coupling and enlarge the coupled frequency component in the nonlinear signal. Therefore, the proposed method based on the above two algorithms can achieve more accurate results of fault diagnosis of gears and rolling bearings. The simulated signal is used to verify its effectiveness in a numerical simulation. Then, the proposed method is conducted for fault diagnosis of gears and rolling bearings in application researches. The fault characteristics of faulty bearings and gears can be extracted successfully in the researches. The experimental results indicate the effectiveness of the novel proposed method.

  1. [Exercise laryngoscopy: a new method for the differential diagnosis of dyspnea on exertion].

    Science.gov (United States)

    Tervonen, Hanna; Iljukov, Sergei; Niskanen, Minna-Liisa; Vilkman, Erkki; Sovijärvi, Anssi; Aaltonen, Leena-Maija

    2011-01-01

    Exertional dyspnea originating from the laryngeal level can be established with certainty only if the paradoxical vocal cord adduction is observed during dyspnea. We have developed a novel diagnostic method, exercise laryngoscopy, which involves observation of the larynx with a flexible endoscope applied via the nose during a bicycle ergometry test. It has been our aim to improve the differential diagnosis of dyspnea on exertion and thus also reduce unnecessary antiasthmatic medication. Exercise laryngoscopy allows examination in the out-patient clinics because the method is well tolerated.

  2. Diagnosis of clinical samples spotted on FTA cards using PCR-based methods.

    Science.gov (United States)

    Jamjoom, Manal; Sultan, Amal H

    2009-04-01

    The broad clinical presentation of Leishmaniasis makes the diagnosis of current and past cases of this disease rather difficult. Differential diagnosis is important because diseases caused by other aetiologies and a clinical spectrum similar to that of leishmaniasis (e.g. leprosy, skin cancers and tuberculosis for CL; malaria and schistosomiasis for VL) are often present in endemic areas of endemicity. Presently, a variety of methods have been developed and tested to aid the identification and diagnosis of Leishmania. The advent of the PCR technology has opened new channels for the diagnosis of leishmaniasis in a variety of clinical materials. PCR is a simple, rapid procedure that has been adapted for diagnosis of leishmaniasis. A range of tools is currently available for the diagnosis and identification of leishmaniasis and Leishmania species, respectively. However, none of these diagnostic tools are examined and tested using samples spotted on FTA cards. Three different PCR-based approaches were examined including: kDNA minicircle, Leishmania 18S rRNA gene and PCR-RFLP of Intergenic region of ribosomal protein. PCR primers were designed that sit within the coding sequences of genes (relatively well conserved) but which amplify across the intervening intergenic sequence (relatively variable). These were used in PCR-RFLP on reference isolates of 10 of the most important Leishmania species: L. donovani, L. infantum, L. major & L. tropica. Digestion of PCR products with restriction enzymes produced species-specific restriction patterns allowed discrimination of reference isolates. The kDNA minicircle primers are highly sensitive in diagnosis of both bone marrow and skin smears from FTA cards. Leishmania 18S rRNA gene conserved region is sensitive in identification of bone marrow smear but less sensitive in diagnosing skin smears. The intergenic nested PCR-RFLP using P5 & P6 as well as P1 & P2 newly designed primers showed high level of reproducibility and sensitivity

  3. Method of Fusion Diagnosis for Dam Service Status Based on Joint Distribution Function of Multiple Points

    Directory of Open Access Journals (Sweden)

    Zhenxiang Jiang

    2016-01-01

    Full Text Available The traditional methods of diagnosing dam service status are always suitable for single measuring point. These methods also reflect the local status of dams without merging multisource data effectively, which is not suitable for diagnosing overall service. This study proposes a new method involving multiple points to diagnose dam service status based on joint distribution function. The function, including monitoring data of multiple points, can be established with t-copula function. Therefore, the possibility, which is an important fusing value in different measuring combinations, can be calculated, and the corresponding diagnosing criterion is established with typical small probability theory. Engineering case study indicates that the fusion diagnosis method can be conducted in real time and the abnormal point can be detected, thereby providing a new early warning method for engineering safety.

  4. Importance of X-ray diagnosis of colorectal polyps as compared to the endoscopic method

    International Nuclear Information System (INIS)

    Lass, B.

    1980-01-01

    The importance of X-ray diagnosis of colorectal polyps as compared with endoscopy is assessed on the basis of the literature and the authoress's own investigations. These make clean that the double contrast method attains a degree of accuracy approaching that of endoscopy. Some investigations by the authoress in 98 patients show that the procedure permits to recognize 72% of polyps under 1 cm of length and 81% above if the patients are well prepared. 4 out of 129 polyps were not detected by endoscopy. Coloscopy is not an infallible method. Both methods should not be viewed as rivalling but as complementary ones. Knowledge of the limitations and methods, and contant endeavour to combine all methods will entail the best diagnostic results. (orig.) [de

  5. Tomography reconstruction methods for damage diagnosis of wood structure in construction field

    Science.gov (United States)

    Qiu, Qiwen; Lau, Denvid

    2018-03-01

    The structural integrity of wood building element plays a critical role in the public safety, which requires effective methods for diagnosis of internal damage inside the wood body. Conventionally, the non-destructive testing (NDT) methods such as X-ray computed tomography, thermography, radar imaging reconstruction method, ultrasonic tomography, nuclear magnetic imaging techniques, and sonic tomography have been used to obtain the information about the internal structure of wood. In this paper, the applications, advantages and disadvantages of these traditional tomography methods are reviewed. Additionally, the present article gives an overview of recently developed tomography approach that relies on the use of mechanical and electromagnetic waves for assessing the structural integrity of wood buildings. This developed tomography reconstruction method is believed to provide a more accurate, reliable, and comprehensive assessment of wood structural integrity

  6. A new constitutive analysis of hexagonal close-packed metal in equal channel angular pressing by crystal plasticity finite element method

    Science.gov (United States)

    Li, Hejie; Öchsner, Andreas; Yarlagadda, Prasad K. D. V.; Xiao, Yin; Furushima, Tsuyoshi; Wei, Dongbin; Jiang, Zhengyi; Manabe, Ken-ichi

    2018-01-01

    Most of hexagonal close-packed (HCP) metals are lightweight metals. With the increasing application of light metal products, the production of light metal is increasingly attracting the attentions of researchers worldwide. To obtain a better understanding of the deformation mechanism of HCP metals (especially for Mg and its alloys), a new constitutive analysis was carried out based on previous research. In this study, combining the theories of strain gradient and continuum mechanics, the equal channel angular pressing process is analyzed and a HCP crystal plasticity constitutive model is developed especially for Mg and its alloys. The influence of elevated temperature on the deformation mechanism of the Mg alloy (slip and twin) is novelly introduced into a crystal plasticity constitutive model. The solution for the new developed constitutive model is established on the basis of the Lagrangian iterations and Newton Raphson simplification.

  7. Diagnosis of Giardia infections by PCR-based methods in children of an endemic area

    Directory of Open Access Journals (Sweden)

    EB David

    2011-01-01

    Full Text Available The present study was designed to estimate the prevalence of Giardia infection in preschool- and school-aged children living in an endemic area. Fecal samples from 573 children were processed by zinc sulfate centrifugal flotation, centrifugal sedimentation (using a commercial device for fecal concentration - TF-Test kit® and polymerase chain reaction (PCR-based methods. Of the stool samples assessed, 277 (48.3% were positive for intestinal parasites and/or commensal protozoa. Centrifugal flotation presented the highest diagnostic sensitivity for Giardia infections. The kappa index revealed that both coproparasitological techniques closely agreed on the Giardia diagnosis (86% versus satisfactory (72% and poor (35% concordances for commensal protozoan and helminth infections, respectively. Concerning Giardia molecular diagnosis, from the 71 microscopy-positive samples, specific amplification of gdh and tpi fragments was noted in 68 (95.7% and 64 (90% samples, respectively. Amplification of gdh and tpi genes was observed, respectively, in 95.7% and 90% of microscopy-positive Giardia samples. For 144 microscopy-negative samples, gdh and tpi gene amplification products were obtained from 8.3% and 35.9% samples, respectively. The agreement between these genes was about 40%. The centrifuge-flotation based method was the most suitable means of Giardia diagnosis assessed in the present study by combining accuracy and low cost.

  8. Computational Intelligence Method for Early Diagnosis Dengue Haemorrhagic Fever Using Fuzzy on Mobile Device

    Directory of Open Access Journals (Sweden)

    Salman Afan

    2014-03-01

    Full Text Available Mortality from Dengue Haemorrhagic Fever (DHF is still increasing in Indonesia particularly in Jakarta. Diagnosis of the dengue shall be made as early as possible so that first aid can be given in expectation of decreasing death risk. The Study will be conducted by developing expert system based on Computational Intelligence Method. On the first year, study will use the Fuzzy Inference System (FIS Method to diagnose Dengue Haemorrhagic Fever particularly in Mobile Device consist of smart phone. Expert system application which particularly using fuzzy system can be applied in mobile device and it is useful to make early diagnosis of Dengue Haemorrhagic Fever that produce outcome faster than laboratory test. The evaluation of this application is conducted by performing accuracy test before and after validation using data of patient who has the Dengue Haemorrhagic Fever. This expert system application is easy, convenient, and practical to use, also capable of making the early diagnosis of Dengue Haemorraghic to avoid mortality in the first stage.

  9. A simple modification of the Baermann method for diagnosis of strongyloidiasis

    Directory of Open Access Journals (Sweden)

    Francisco Hernández-Chavarría

    2001-08-01

    Full Text Available The diagnosis of Strongyloides stercoralis infections is routinely made by microscopic observation of larvae in stool samples, a low sensitivity method, or by other, most effective methods, such as the Baermann or agar culture plate methods. We propose in this paper a practical modification of Baermann method. One hundred and six stool samples from alcoholic patients were analyzed using the direct smear test, agar culture plate method, the standard Baermann method, and its proposed modification. For this modification the funnel used in the original version of the method is substituted by a test tube with a rubber stopper, perforated to allow insertion of a pipette tip. The tube with a fecal suspension is inverted over another tube containing 6 ml of saline solution and incubated at 37°C for at least 2 h. The saline solution from the second tube is centrifuged and the pellet is observed microscopically. Larva of S. stercoralis were detected in six samples (5.7% by the two versions of the Baermann method. Five samples were positive using the agar culture plate method, and only in two samples the larva were observed using direct microscopic observation of fecal smears. Cysts of Endolimax nana and Entamoeba histolytica/dyspar were also detected in the modification of Baermann method. Data obtained by the modified Baermann method suggest that this methodology may helps concentrate larvae of S. stercoralis as efficiently as the original method.

  10. Radionuclide Methods in the Diagnosis of Sacroiliitis in Patients with Spondyloarthritis: An Update

    Directory of Open Access Journals (Sweden)

    Karina Zilber

    2016-10-01

    Full Text Available Sacroiliitis, inflammation of the sacroiliac joint (SIJ, is the hallmark of ankylosing spondylitis and spondyloarthritis (SpA in general. The arsenal of recommended diagnostic modalities for imaging of the SIJ is scanty and, in practice, includes only conventional X-rays and magnetic resonance imaging (MRI. This review suggests that bone scintigraphy, particularly single-photon emission computed tomography (SPECT with calculation of indices, or SPECT in combination with low-dose computed tomography (CT can be a sensitive and specific tool for the diagnosis of sacroiliitis and can be used as part of the individualized approach to the diagnosis of axial SpA. In addition, [18F]fluoride positron emission tomography (PET/CT imaging and immunoscintigraphy, using labeled monoclonal anti-cytokine antibodies, are promising methods of current scientific interest in this field.

  11. Critical analysis of the images methods in detection and diagnosis in breast cancer

    International Nuclear Information System (INIS)

    Mendonca, Maria H.S.

    1995-01-01

    The female breast cancer is a relevant health issue among female population, due its incidence and remarkable effects in the biological, psychological and social levels. Its early diagnosis is important because it allows more effective treatments and enhances changes of cure, even allowing conservative surgical procedures. To make this possible it is essential the periodic breast imaging exams. The available imaging methods to date are: mammography, ultrasonography, thermography, nuclear medicine, computed tomography and MRI. All these methods have their advantages and disadvantages, applications and limitations and some are even in experimental stages. These methods must exercised in association to become more effective. Mammography is still, beyond and doubt the elected breast exam. even though imperfect. It must be performed repeatedly at periodic intervals depending upon the intrinsic conditions of the patient. The other methods complement the mammographic findings, clearing some of them. In this paper, the imaging methods available in our environmental for detected diagnosis of the early breast cancer are analyzed with emphasis in mammography and ultrasonography. Their advantages, disadvantages, indications and limitations are discussed. (author)

  12. Multiple-Fault Diagnosis Method Based on Multiscale Feature Extraction and MSVM_PPA

    Directory of Open Access Journals (Sweden)

    Min Zhang

    2018-01-01

    Full Text Available Identification of rolling bearing fault patterns, especially for the compound faults, has attracted notable attention and is still a challenge in fault diagnosis. In this paper, a novel method called multiscale feature extraction (MFE and multiclass support vector machine (MSVM with particle parameter adaptive (PPA is proposed. MFE is used to preprocess the process signals, which decomposes the data into intrinsic mode function by empirical mode decomposition method, and instantaneous frequency of decomposed components was obtained by Hilbert transformation. Then, statistical features and principal component analysis are utilized to extract significant information from the features, to get effective data from multiple faults. MSVM method with PPA parameters optimization will classify the fault patterns. The results of a case study of the rolling bearings faults data from Case Western Reserve University show that (1 the proposed intelligent method (MFE_PPA_MSVM improves the classification recognition rate; (2 the accuracy will decline when the number of fault patterns increases; (3 prediction accuracy can be the best when the training set size is increased to 70% of the total sample set. It verifies the method is feasible and efficient for fault diagnosis.

  13. Comparison of nine DNA extraction methods for the diagnosis of bovine tuberculosis by real time PCR

    Directory of Open Access Journals (Sweden)

    André Moura

    2016-07-01

    Full Text Available ABSTRACT: Bovine tuberculosis is an infectious disease with a high impact on the cattle industry, particularly in developing countries. PCR is a very sensitive method for detection of infectious agents, but the sensitivity of molecular diagnosis is largely dependent on the efficiency of the DNA extraction methods. The objective of this study was to evaluate DNA extraction methods for direct detection of Mycobacterium bovis in bovine tissue. Nine commercial kits for DNA extraction were evaluated when combined with two real time PCRs. The DNeasy Blood & Tissue Kit from QIAGEN showed better performance and sensitivity followed by the DNA Mini Kit RBC and FTA Elute Micro Card. Results suggested that, even when the analytical sensitivity of the qPCR is very high, the extraction method can influence the diagnostic sensitivity.

  14. A novel KFCM based fault diagnosis method for unknown faults in satellite reaction wheels.

    Science.gov (United States)

    Hu, Di; Sarosh, Ali; Dong, Yun-Feng

    2012-03-01

    Reaction wheels are one of the most critical components of the satellite attitude control system, therefore correct diagnosis of their faults is quintessential for efficient operation of these spacecraft. The known faults in any of the subsystems are often diagnosed by supervised learning algorithms, however, this method fails to work correctly when a new or unknown fault occurs. In such cases an unsupervised learning algorithm becomes essential for obtaining the correct diagnosis. Kernel Fuzzy C-Means (KFCM) is one of the unsupervised algorithms, although it has its own limitations; however in this paper a novel method has been proposed for conditioning of KFCM method (C-KFCM) so that it can be effectively used for fault diagnosis of both known and unknown faults as in satellite reaction wheels. The C-KFCM approach involves determination of exact class centers from the data of known faults, in this way discrete number of fault classes are determined at the start. Similarity parameters are derived and determined for each of the fault data point. Thereafter depending on the similarity threshold each data point is issued with a class label. The high similarity points fall into one of the 'known-fault' classes while the low similarity points are labeled as 'unknown-faults'. Simulation results show that as compared to the supervised algorithm such as neural network, the C-KFCM method can effectively cluster historical fault data (as in reaction wheels) and diagnose the faults to an accuracy of more than 91%. Copyright © 2011 ISA. Published by Elsevier Ltd. All rights reserved.

  15. Partly Duffing Oscillator Stochastic Resonance Method and Its Application on Mechanical Fault Diagnosis

    Directory of Open Access Journals (Sweden)

    Jian Dang

    2016-01-01

    Full Text Available Due to the fact that the slight fault signals in early failure of mechanical system are usually submerged in heavy background noise, it is unfeasible to extract the weak fault feature via the traditional vibration analysis. Stochastic resonance (SR, as a method of utilizing noise to amplify weak signals in nonlinear dynamical systems, can detect weak signals overwhelmed in the noise. However, based on the analysis of the impact of noise intensity on SR effect, it is concluded that the detection results are dramatically limited by the noise intensity of measured signals, especially for incipient fault feature of mechanical system with poor working environment. Therefore, this paper proposes a partly Duffing oscillator SR method to extract the fault feature of mechanical system. In this method, to locate the appearance of weak fault feature and decrease noise intensity, the permutation entropy index is constructed to select the measured signals for the input of Duffing oscillator system. Then, according to the regulation of system parameters, a reasonable match between the selected signals and Duffing oscillator model is achieved to produce a SR phenomenon and realize the fault diagnosis of mechanical system. Experiment results demonstrate that the proposed method achieves a better effect on the fault diagnosis of mechanical system.

  16. A Method for Medical Diagnosis Based on Optical Fluence Rate Distribution at Tissue Surface.

    Science.gov (United States)

    Hamdy, Omnia; El-Azab, Jala; Al-Saeed, Tarek A; Hassan, Mahmoud F; Solouma, Nahed H

    2017-09-20

    Optical differentiation is a promising tool in biomedical diagnosis mainly because of its safety. The optical parameters' values of biological tissues differ according to the histopathology of the tissue and hence could be used for differentiation. The optical fluence rate distribution on tissue boundaries depends on the optical parameters. So, providing image displays of such distributions can provide a visual means of biomedical diagnosis. In this work, an experimental setup was implemented to measure the spatially-resolved steady state diffuse reflectance and transmittance of native and coagulated chicken liver and native and boiled breast chicken skin at 635 and 808 nm wavelengths laser irradiation. With the measured values, the optical parameters of the samples were calculated in vitro using a combination of modified Kubelka-Munk model and Bouguer-Beer-Lambert law. The estimated optical parameters values were substituted in the diffusion equation to simulate the fluence rate at the tissue surface using the finite element method. Results were verified with Monte-Carlo simulation. The results obtained showed that the diffuse reflectance curves and fluence rate distribution images can provide discrimination tools between different tissue types and hence can be used for biomedical diagnosis.

  17. The 32P test and other methods in the diagnosis of intraocular tumours

    International Nuclear Information System (INIS)

    Dijk, R.A. van.

    1978-01-01

    Why the 32 P test was reintroduced into The Netherlands for the diagnosis of intraocular tumours and how the present study was started is explained. The physical features of 32 P and the biochemical behaviour of radioactive phosphate in healthy and neoplastic tissue are described. The complications, which can be encountered after the administration of 32 P, are mentioned. A review of the 32 P test in ophthalmology is given, with special attention to the methods used and the development of instruments for the measurements. The way in which the 32 P test was performed in this study is described. The 32 P test results obtained in the patients of this study are described. A good diagnostic accuracy of the 32 P test was present in the 192 lesions located in the posterior segment, with a correct result obtained in 186 patients. Only three malignant and three benign lesions showed an incorrect test result. The results obtained with scintigraphy, fluorescein angiography, perimetry, transillumination, and ultrasonography are given and compared with data in the literature. The value of fluorescein angiography, perimetry, and the 32 P test for the diagnosis of various lesions, with relevance to the differential diagnosis of a choroidal tumour, is described. The 32 P tests performed in 12 patients with an extraocular lesion are mentioned. (Auth.)

  18. A Method for Medical Diagnosis Based on Optical Fluence Rate Distribution at Tissue Surface

    Directory of Open Access Journals (Sweden)

    Omnia Hamdy

    2017-09-01

    Full Text Available Optical differentiation is a promising tool in biomedical diagnosis mainly because of its safety. The optical parameters’ values of biological tissues differ according to the histopathology of the tissue and hence could be used for differentiation. The optical fluence rate distribution on tissue boundaries depends on the optical parameters. So, providing image displays of such distributions can provide a visual means of biomedical diagnosis. In this work, an experimental setup was implemented to measure the spatially-resolved steady state diffuse reflectance and transmittance of native and coagulated chicken liver and native and boiled breast chicken skin at 635 and 808 nm wavelengths laser irradiation. With the measured values, the optical parameters of the samples were calculated in vitro using a combination of modified Kubelka-Munk model and Bouguer-Beer-Lambert law. The estimated optical parameters values were substituted in the diffusion equation to simulate the fluence rate at the tissue surface using the finite element method. Results were verified with Monte-Carlo simulation. The results obtained showed that the diffuse reflectance curves and fluence rate distribution images can provide discrimination tools between different tissue types and hence can be used for biomedical diagnosis.

  19. Computer aided diagnosis based on medical image processing and artificial intelligence methods

    Science.gov (United States)

    Stoitsis, John; Valavanis, Ioannis; Mougiakakou, Stavroula G.; Golemati, Spyretta; Nikita, Alexandra; Nikita, Konstantina S.

    2006-12-01

    Advances in imaging technology and computer science have greatly enhanced interpretation of medical images, and contributed to early diagnosis. The typical architecture of a Computer Aided Diagnosis (CAD) system includes image pre-processing, definition of region(s) of interest, features extraction and selection, and classification. In this paper, the principles of CAD systems design and development are demonstrated by means of two examples. The first one focuses on the differentiation between symptomatic and asymptomatic carotid atheromatous plaques. For each plaque, a vector of texture and motion features was estimated, which was then reduced to the most robust ones by means of ANalysis of VAriance (ANOVA). Using fuzzy c-means, the features were then clustered into two classes. Clustering performances of 74%, 79%, and 84% were achieved for texture only, motion only, and combinations of texture and motion features, respectively. The second CAD system presented in this paper supports the diagnosis of focal liver lesions and is able to characterize liver tissue from Computed Tomography (CT) images as normal, hepatic cyst, hemangioma, and hepatocellular carcinoma. Five texture feature sets were extracted for each lesion, while a genetic algorithm based feature selection method was applied to identify the most robust features. The selected feature set was fed into an ensemble of neural network classifiers. The achieved classification performance was 100%, 93.75% and 90.63% in the training, validation and testing set, respectively. It is concluded that computerized analysis of medical images in combination with artificial intelligence can be used in clinical practice and may contribute to more efficient diagnosis.

  20. Computer aided diagnosis based on medical image processing and artificial intelligence methods

    International Nuclear Information System (INIS)

    Stoitsis, John; Valavanis, Ioannis; Mougiakakou, Stavroula G.; Golemati, Spyretta; Nikita, Alexandra; Nikita, Konstantina S.

    2006-01-01

    Advances in imaging technology and computer science have greatly enhanced interpretation of medical images, and contributed to early diagnosis. The typical architecture of a Computer Aided Diagnosis (CAD) system includes image pre-processing, definition of region(s) of interest, features extraction and selection, and classification. In this paper, the principles of CAD systems design and development are demonstrated by means of two examples. The first one focuses on the differentiation between symptomatic and asymptomatic carotid atheromatous plaques. For each plaque, a vector of texture and motion features was estimated, which was then reduced to the most robust ones by means of ANalysis of VAriance (ANOVA). Using fuzzy c-means, the features were then clustered into two classes. Clustering performances of 74%, 79%, and 84% were achieved for texture only, motion only, and combinations of texture and motion features, respectively. The second CAD system presented in this paper supports the diagnosis of focal liver lesions and is able to characterize liver tissue from Computed Tomography (CT) images as normal, hepatic cyst, hemangioma, and hepatocellular carcinoma. Five texture feature sets were extracted for each lesion, while a genetic algorithm based feature selection method was applied to identify the most robust features. The selected feature set was fed into an ensemble of neural network classifiers. The achieved classification performance was 100%, 93.75% and 90.63% in the training, validation and testing set, respectively. It is concluded that computerized analysis of medical images in combination with artificial intelligence can be used in clinical practice and may contribute to more efficient diagnosis

  1. Computer aided diagnosis based on medical image processing and artificial intelligence methods

    Energy Technology Data Exchange (ETDEWEB)

    Stoitsis, John [National Technical University of Athens, School of Electrical and Computer Engineering, Athens 157 71 (Greece)]. E-mail: stoitsis@biosim.ntua.gr; Valavanis, Ioannis [National Technical University of Athens, School of Electrical and Computer Engineering, Athens 157 71 (Greece); Mougiakakou, Stavroula G. [National Technical University of Athens, School of Electrical and Computer Engineering, Athens 157 71 (Greece); Golemati, Spyretta [National Technical University of Athens, School of Electrical and Computer Engineering, Athens 157 71 (Greece); Nikita, Alexandra [University of Athens, Medical School 152 28 Athens (Greece); Nikita, Konstantina S. [National Technical University of Athens, School of Electrical and Computer Engineering, Athens 157 71 (Greece)

    2006-12-20

    Advances in imaging technology and computer science have greatly enhanced interpretation of medical images, and contributed to early diagnosis. The typical architecture of a Computer Aided Diagnosis (CAD) system includes image pre-processing, definition of region(s) of interest, features extraction and selection, and classification. In this paper, the principles of CAD systems design and development are demonstrated by means of two examples. The first one focuses on the differentiation between symptomatic and asymptomatic carotid atheromatous plaques. For each plaque, a vector of texture and motion features was estimated, which was then reduced to the most robust ones by means of ANalysis of VAriance (ANOVA). Using fuzzy c-means, the features were then clustered into two classes. Clustering performances of 74%, 79%, and 84% were achieved for texture only, motion only, and combinations of texture and motion features, respectively. The second CAD system presented in this paper supports the diagnosis of focal liver lesions and is able to characterize liver tissue from Computed Tomography (CT) images as normal, hepatic cyst, hemangioma, and hepatocellular carcinoma. Five texture feature sets were extracted for each lesion, while a genetic algorithm based feature selection method was applied to identify the most robust features. The selected feature set was fed into an ensemble of neural network classifiers. The achieved classification performance was 100%, 93.75% and 90.63% in the training, validation and testing set, respectively. It is concluded that computerized analysis of medical images in combination with artificial intelligence can be used in clinical practice and may contribute to more efficient diagnosis.

  2. Nonparametric method for failures diagnosis in the actuating subsystem of aircraft control system

    Science.gov (United States)

    Terentev, M. N.; Karpenko, S. S.; Zybin, E. Yu; Kosyanchuk, V. V.

    2018-02-01

    In this paper we design a nonparametric method for failures diagnosis in the aircraft control system that uses the measurements of the control signals and the aircraft states only. It doesn’t require a priori information of the aircraft model parameters, training or statistical calculations, and is based on analytical nonparametric one-step-ahead state prediction approach. This makes it possible to predict the behavior of unidentified and failure dynamic systems, to weaken the requirements to control signals, and to reduce the diagnostic time and problem complexity.

  3. A diagnosis method for physical systems using a multi-modeling approach

    International Nuclear Information System (INIS)

    Thetiot, R.

    2000-01-01

    In this thesis we propose a method for diagnosis problem solving. This method is based on a multi-modeling approach describing both normal and abnormal behavior of a system. This modeling approach allows to represent a system at different abstraction levels (behavioral, functional and teleological. Fundamental knowledge is described according to a bond-graph representation. We show that bond-graph representation can be exploited in order to generate (completely or partially) the functional models. The different models of the multi-modeling approach allows to define the functional state of a system at different abstraction levels. We exploit this property to exonerate sub-systems for which the expected behavior is observed. The behavioral and functional descriptions of the remaining sub-systems are exploited hierarchically in a two steps process. In a first step, the abnormal behaviors explaining some observations are identified. In a second step, the remaining unexplained observations are used to generate conflict sets and thus the consistency based diagnoses. The modeling method and the diagnosis process have been applied to a Reactor Coolant Pump Sets. This application illustrates the concepts described in this thesis and shows its potentialities. (authors)

  4. Application of L1/2 regularization logistic method in heart disease diagnosis.

    Science.gov (United States)

    Zhang, Bowen; Chai, Hua; Yang, Ziyi; Liang, Yong; Chu, Gejin; Liu, Xiaoying

    2014-01-01

    Heart disease has become the number one killer of human health, and its diagnosis depends on many features, such as age, blood pressure, heart rate and other dozens of physiological indicators. Although there are so many risk factors, doctors usually diagnose the disease depending on their intuition and experience, which requires a lot of knowledge and experience for correct determination. To find the hidden medical information in the existing clinical data is a noticeable and powerful approach in the study of heart disease diagnosis. In this paper, sparse logistic regression method is introduced to detect the key risk factors using L(1/2) regularization on the real heart disease data. Experimental results show that the sparse logistic L(1/2) regularization method achieves fewer but informative key features than Lasso, SCAD, MCP and Elastic net regularization approaches. Simultaneously, the proposed method can cut down the computational complexity, save cost and time to undergo medical tests and checkups, reduce the number of attributes needed to be taken from patients.

  5. An Automatic Diagnosis Method of Facial Acne Vulgaris Based on Convolutional Neural Network.

    Science.gov (United States)

    Shen, Xiaolei; Zhang, Jiachi; Yan, Chenjun; Zhou, Hong

    2018-04-11

    In this paper, we present a new automatic diagnosis method for facial acne vulgaris which is based on convolutional neural networks (CNNs). To overcome the shortcomings of previous methods which were the inability to classify enough types of acne vulgaris. The core of our method is to extract features of images based on CNNs and achieve classification by classifier. A binary-classifier of skin-and-non-skin is used to detect skin area and a seven-classifier is used to achieve the classification task of facial acne vulgaris and healthy skin. In the experiments, we compare the effectiveness of our CNN and the VGG16 neural network which is pre-trained on the ImageNet data set. We use a ROC curve to evaluate the performance of binary-classifier and use a normalized confusion matrix to evaluate the performance of seven-classifier. The results of our experiments show that the pre-trained VGG16 neural network is effective in extracting features from facial acne vulgaris images. And the features are very useful for the follow-up classifiers. Finally, we try applying the classifiers both based on the pre-trained VGG16 neural network to assist doctors in facial acne vulgaris diagnosis.

  6. An Efficient Quality-Related Fault Diagnosis Method for Real-Time Multimode Industrial Process

    Directory of Open Access Journals (Sweden)

    Kaixiang Peng

    2017-01-01

    Full Text Available Focusing on quality-related complex industrial process performance monitoring, a novel multimode process monitoring method is proposed in this paper. Firstly, principal component space clustering is implemented under the guidance of quality variables. Through extraction of model tags, clustering information of original training data can be acquired. Secondly, according to multimode characteristics of process data, the monitoring model integrated Gaussian mixture model with total projection to latent structures is effective after building the covariance description form. The multimode total projection to latent structures (MTPLS model is the foundation of problem solving about quality-related monitoring for multimode processes. Then, a comprehensive statistics index is defined which is based on the posterior probability of the monitored samples belonging to each Gaussian component in the Bayesian theory. After that, a combined index is constructed for process monitoring. Finally, motivated by the application of traditional contribution plot in fault diagnosis, a gradient contribution rate is applied for analyzing the variation of variable contribution rate along samples. Our method can ensure the implementation of online fault monitoring and diagnosis for multimode processes. Performances of the whole proposed scheme are verified in a real industrial, hot strip mill process (HSMP compared with some existing methods.

  7. A new CFD based non-invasive method for functional diagnosis of coronary stenosis.

    Science.gov (United States)

    Xie, Xinzhou; Zheng, Minwen; Wen, Didi; Li, Yabing; Xie, Songyun

    2018-03-22

    Accurate functional diagnosis of coronary stenosis is vital for decision making in coronary revascularization. With recent advances in computational fluid dynamics (CFD), fractional flow reserve (FFR) can be derived non-invasively from coronary computed tomography angiography images (FFR CT ) for functional measurement of stenosis. However, the accuracy of FFR CT is limited due to the approximate modeling approach of maximal hyperemia conditions. To overcome this problem, a new CFD based non-invasive method is proposed. Instead of modeling maximal hyperemia condition, a series of boundary conditions are specified and those simulated results are combined to provide a pressure-flow curve for a stenosis. Then, functional diagnosis of stenosis is assessed based on parameters derived from the obtained pressure-flow curve. The proposed method is applied to both idealized and patient-specific models, and validated with invasive FFR in six patients. Results show that additional hemodynamic information about the flow resistances of a stenosis is provided, which cannot be directly obtained from anatomy information. Parameters derived from the simulated pressure-flow curve show a linear and significant correlations with invasive FFR (r > 0.95, P < 0.05). The proposed method can assess flow resistances by the pressure-flow curve derived parameters without modeling of maximal hyperemia condition, which is a new promising approach for non-invasive functional assessment of coronary stenosis.

  8. A quantitative assessment method for the NPP operators' diagnosis of accidents

    International Nuclear Information System (INIS)

    Kim, M. C.; Seong, P. H.

    2003-01-01

    In this research, we developed a quantitative model for the operators' diagnosis of the accident situation when an accident occurs in a nuclear power plant. After identifying the occurrence probabilities of accidents, the unavailabilities of various information sources, and the causal relationship between accidents and information sources, Bayesian network is used for the analysis of the change in the occurrence probabilities of accidents as the operators receive the information related to the status of the plant. The developed method is applied to a simple example case and it turned out that the developed method is a systematic quantitative analysis method which can cope with complex relationship between the accidents and information sources and various variables such accident occurrence probabilities and unavailabilities of various information sources

  9. Biochemical method for fast affinity diagnosis in grape-vine transplantation

    International Nuclear Information System (INIS)

    Lilov, D.

    1977-01-01

    Long term experiments have proved the affinity of cv. Mavroud in transplantations on various root stocks. Best affinity was observed in the combination cv. Mavroud X Riparia tomanteau, followed, in a descending order, by the combinations Mavroud X Mavroud (autotransplantation), Mavroud X Berlandieri X Riparia Kobber SBB and Mavroud X Riparia 33 EM. In view to establish indices for predicting the transplantation affinity a great number of physiological-biochemical and morphological-anatomical studies were carried out. The results obtained showed that a most clearly expressed positive, statistically significant correlation exists between the amount of 15 N transported from the root stock to the scions, shoots and leaves. As a result, a biochemical method for fast affinity diagnosis in grape-vine transplantation has been developed. The reliability of the method has been checked up also with other cultivars. Up to the present no such method was known in grape-vine science and practice. (author)

  10. Comparison of Fluorescence Microscopy and Different Growth Media Culture Methods for Acanthamoeba Keratitis Diagnosis.

    Science.gov (United States)

    Peretz, Avi; Geffen, Yuval; Socea, Soergiu D; Pastukh, Nina; Graffi, Shmuel

    2015-08-01

    Acanthamoeba keratitis (AK), a potentially blinding infection of the cornea, is caused by a free-living protozoan. Culture and microscopic examination of corneal scraping tissue material is the conventional method for identifying Acanthamoeba. In this article, we compared several methods for AK diagnosis of 32 patients: microscopic examination using fluorescent dye, specific culture on growth media-non-nutrient agar (NNA), culture on liquid growth media-peptone yeast glucose (PYG), and TYI-S-33. AK was found in 14 patients. Thirteen of the specimens were found AK positive by fluorescence microscopic examination, 11 specimens were found AK positive on PYG growth media, and 9 specimens were found AK positive on TYI-S-33 growth media. Only five specimens were found AK positive on NNA growth media. Therefore, we recommend using fluorescence microscopy technique and culture method, especially PYG liquid media. © The American Society of Tropical Medicine and Hygiene.

  11. Diagnosis of Intermittent Faults in IGBTs Using the Latent Nestling Method with Hybrid Coloured Petri Nets

    Directory of Open Access Journals (Sweden)

    Leonardo Rodriguez-Urrego

    2015-01-01

    Full Text Available This paper presents a fault diagnosis application of the Latent Nestling Method to IGBTs. The paper extends the Latent Nestling Method based in Coloured Petri Nets (CPNs to hybrid systems in such a manner that IGBTs performance can be modeled. CPNs allow for an enhanced capability for synthesis and modeling in contrast to the classical phenomena of combinational state explosion when Finite State Machine methods are applied. We present an IGBT model with different fault modes including those of intermittent nature that can be used advantageously as predictive symptoms within a predictive maintenance strategy. Ageing stress tests have been experimentally applied to the IGBTs modules and intermittent faults are diagnosed as precursors of permanent failures. In addition, ageing is validated with morphological analysis (Scanning Electron Microscopy and semiqualitative analysis (Energy Dispersive Spectrometry.

  12. A study of interpolation method in diagnosis of carpal tunnel syndrome

    Directory of Open Access Journals (Sweden)

    Alireza Ashraf

    2013-01-01

    Full Text Available Context: The low correlation between the patients′ signs and symptoms of carpal tunnel syndrome (CTS and results of electrodiagnostic tests makes the diagnosis challenging in mild cases. Interpolation is a mathematical method for finding median nerve conduction velocity (NCV exactly at carpal tunnel site. Therefore, it may be helpful in diagnosis of CTS in patients with equivocal test results. Aim: The aim of this study is to evaluate interpolation method as a CTS diagnostic test. Settings and Design: Patients with two or more clinical symptoms and signs of CTS in a median nerve territory with 3.5 ms ≤ distal median sensory latency <4.6 ms from those who came to our electrodiagnostic clinics and also, age matched healthy control subjects were recruited in the study. Materials and Methods: Median compound motor action potential and median sensory nerve action potential latencies were measured by a MEDLEC SYNERGY VIASIS electromyography and conduction velocities were calculated by both routine method and interpolation technique. Statistical Analysis Used: Chi-square and Student′s t-test were used for comparing group differences. Cut-off points were calculated using receiver operating characteristic curve. Results: A sensitivity of 88%, specificity of 67%, positive predictive value (PPV and negative predictive value (NPV of 70.8% and 84.7% were obtained for median motor NCV and a sensitivity of 98.3%, specificity of 91.7%, PPV and NPV of 91.9% and 98.2% were obtained for median sensory NCV with interpolation technique. Conclusions: Median motor interpolation method is a good technique, but it has less sensitivity and specificity than median sensory interpolation method.

  13. New Infrared spectroscopic methods for tumor diagnosis and medicinal plants analytics

    International Nuclear Information System (INIS)

    Pezzei, C.

    2012-01-01

    This work was done to verify the feasibility of infrared spectroscopy as a method for tumor diagnosis and medicinal plants analysis. The method of IR imaging has been successfully used for the diagnosis of prostate-, bladder- and oral squamous cell carcinoma as well as for localization of different ingredients of plant roots. All measurements have been done with a resolution down to 1,2 µm. As a non-invasive method, IR imaging can be used for qualitative analysis of 2-dimensional chemical structures and distribution of these substances in plant roots. It was found that IR imaging can be used for detecting cancer-affected areas in tissue-samples. For more profound results, IR-imaging has to be combined with chemometric evaluation methods like multi- and univariate data analysis. Measurements applying that combination of methods allow the identification of cancer-affected areas of tissue-samples of prostate-, bladder- and oral squamous cell carcinoma as well as an illustration of the local distribution of components like carbon-hydrates, proteins, lipids, amides and nucleic acids in samples from Urtica dioica, Phytolacca americana, Levisticum officinale, Primula veris, Cimicifuga racemosa and Gentiana lutea. All research was done by using state of the art technology for IR-imaging and image processing. It was found that IR-imaging can be used for localizing dissolved substances in roots of medical plants with a high resolution down to 1,2 µm. This work shows that different species of Polygala can be identified using FT-NIR and FT-IR spectroscopy. Future developments of more sophisticated and powerful detectors will help to establish IR-imaging as an objective technology for diagnostics of cancer as well as a method in the field of research on medical plants and botany in general. (author) [de

  14. Application of an improved maximum correlated kurtosis deconvolution method for fault diagnosis of rolling element bearings

    Science.gov (United States)

    Miao, Yonghao; Zhao, Ming; Lin, Jing; Lei, Yaguo

    2017-08-01

    The extraction of periodic impulses, which are the important indicators of rolling bearing faults, from vibration signals is considerably significance for fault diagnosis. Maximum correlated kurtosis deconvolution (MCKD) developed from minimum entropy deconvolution (MED) has been proven as an efficient tool for enhancing the periodic impulses in the diagnosis of rolling element bearings and gearboxes. However, challenges still exist when MCKD is applied to the bearings operating under harsh working conditions. The difficulties mainly come from the rigorous requires for the multi-input parameters and the complicated resampling process. To overcome these limitations, an improved MCKD (IMCKD) is presented in this paper. The new method estimates the iterative period by calculating the autocorrelation of the envelope signal rather than relies on the provided prior period. Moreover, the iterative period will gradually approach to the true fault period through updating the iterative period after every iterative step. Since IMCKD is unaffected by the impulse signals with the high kurtosis value, the new method selects the maximum kurtosis filtered signal as the final choice from all candidates in the assigned iterative counts. Compared with MCKD, IMCKD has three advantages. First, without considering prior period and the choice of the order of shift, IMCKD is more efficient and has higher robustness. Second, the resampling process is not necessary for IMCKD, which is greatly convenient for the subsequent frequency spectrum analysis and envelope spectrum analysis without resetting the sampling rate. Third, IMCKD has a significant performance advantage in diagnosing the bearing compound-fault which expands the application range. Finally, the effectiveness and superiority of IMCKD are validated by a number of simulated bearing fault signals and applying to compound faults and single fault diagnosis of a locomotive bearing.

  15. Impact of serology and molecular methods on improving the microbiologic diagnosis of infective endocarditis in Egypt.

    Science.gov (United States)

    El-Kholy, Amany Aly; El-Rachidi, Nevine Gamal El-din; El-Enany, Mervat Gaber; AbdulRahman, Eiman Mohammed; Mohamed, Reem Mostafa; Rizk, Hussien Hasan

    2015-10-01

    Conventional diagnosis of infective endocarditis (IE) is based mainly on culture-dependent methods that may fail because of antibiotic therapy or fastidious microorganisms. We aimed to evaluate the added values of serological and molecular methods for diagnosis of infective endocarditis. One hundred and fifty-six cases of suspected endocarditis were enrolled in the study. For each patient, three sets of blood culture were withdrawn and serum sample was collected for Brucella, Bartonella and Coxiella burnetii antibody testing. Galactomannan antigen was added if fungal endocarditis was suspected. Broad range PCR targeting bacterial and fungal pathogens were done on blood culture bottles followed by sequencing. Culture and molecular studies were done on excised valve tissue when available. One hundred and thirty-two cases were diagnosed as definite IE. Causative organisms were detected by blood cultures in 40 (30.3 %) of cases. Blood culture-negative endocarditis (BCNE) represented 69.7 %. Of these cases, PCR followed by sequencing on blood and valvular tissue could diagnose five cases of Aspergillus flavus. Eleven patients with BCNE (8.3 %) were diagnosed as zoonotic endocarditis by serology and PCR including five cases of Brucella spp, four cases of Bartonella spp and two cases of Coxiella burnetii. PCR detected three cases of Brucella spp and two cases of Bartonella spp, while cases of Coxiella burnetii were PCR negative. The results of all diagnostic tools decreased the percentage of non-identified cases of BCNE from 69.7 to 49.2 %. Our data underline the role of serologic and molecular tools for the diagnosis of blood culture-negative endocarditis.

  16. Application of nuclear medicine methods for diagnosis of urolithiasis and its complications

    International Nuclear Information System (INIS)

    Hadzhiyska, V.

    2012-01-01

    The most common complications of urolithiasis are obstructive nephropathy and pyelonephritis, which often lead to irreversible consequences for the affected kidney. For the diagnosis is not sufficient just to visualize the stone, but also to evaluate the extent of functional changes in renal parenchyma, which will determine the type of therapeutic approach. The most common diagnostic algorithm of imaging methods in the diagnosis of urolithiasis includes ultrasound, X-ray overview and intravenous urography. Less commonly are performed CT, renal scintigraphy and retrograde urography and others. Problems in application of that algorithm are mainly related to incorrect localization of stones and difficulties to assess its effects on renal function. Dynamic renal scintigraphy (DRS) and its variety the diuretic scintigraphy is an established method for assessing the functional status of parenhima and drainage disorders of the kidney in renal colic and long standing hydronephrosis. Advantages of the method is rapid, accurate and noninvasive determination of the renal parenchyma and function, urodynamics of upper urinary tract, and the ability to present the relative percentage contribution of each kidney in total renal function. DRS is characterized by precise quantitative results, lack of bias and low radiation dose. However, recently in the literature we found some contradictory views on the application protocol and the importance of diuretic renal scintigraphy in the evaluation of renal obstruction. Moreover, there are some different viewpoints about the exact location of DRS in the diagnostic algorithm of patients with urolithiasis. In could be summarized that there are various imaging methods which provide extensive diagnostic capabilities in diagnoses of urolithiasis and its complications. Nevertheless, an express and complex method that combine functional and morphological data and provides comprehensive and reliable information hasn't been described yet. (authors)

  17. Combined expert system/neural networks method for process fault diagnosis

    Science.gov (United States)

    Reifman, Jaques; Wei, Thomas Y. C.

    1995-01-01

    A two-level hierarchical approach for process fault diagnosis is an operating system employs a function-oriented approach at a first level and a component characteristic-oriented approach at a second level, where the decision-making procedure is structured in order of decreasing intelligence with increasing precision. At the first level, the diagnostic method is general and has knowledge of the overall process including a wide variety of plant transients and the functional behavior of the process components. An expert system classifies malfunctions by function to narrow the diagnostic focus to a particular set of possible faulty components that could be responsible for the detected functional misbehavior of the operating system. At the second level, the diagnostic method limits its scope to component malfunctions, using more detailed knowledge of component characteristics. Trained artificial neural networks are used to further narrow the diagnosis and to uniquely identify the faulty component by classifying the abnormal condition data as a failure of one of the hypothesized components through component characteristics. Once an anomaly is detected, the hierarchical structure is used to successively narrow the diagnostic focus from a function misbehavior, i.e., a function oriented approach, until the fault can be determined, i.e., a component characteristic-oriented approach.

  18. Combined expert system/neural networks method for process fault diagnosis

    Science.gov (United States)

    Reifman, J.; Wei, T.Y.C.

    1995-08-15

    A two-level hierarchical approach for process fault diagnosis of an operating system employs a function-oriented approach at a first level and a component characteristic-oriented approach at a second level, where the decision-making procedure is structured in order of decreasing intelligence with increasing precision. At the first level, the diagnostic method is general and has knowledge of the overall process including a wide variety of plant transients and the functional behavior of the process components. An expert system classifies malfunctions by function to narrow the diagnostic focus to a particular set of possible faulty components that could be responsible for the detected functional misbehavior of the operating system. At the second level, the diagnostic method limits its scope to component malfunctions, using more detailed knowledge of component characteristics. Trained artificial neural networks are used to further narrow the diagnosis and to uniquely identify the faulty component by classifying the abnormal condition data as a failure of one of the hypothesized components through component characteristics. Once an anomaly is detected, the hierarchical structure is used to successively narrow the diagnostic focus from a function misbehavior, i.e., a function oriented approach, until the fault can be determined, i.e., a component characteristic-oriented approach. 9 figs.

  19. The sensitivity of clinical diagnostic methods in the diagnosis of diabetic neuropathy.

    Science.gov (United States)

    Onde, M E; Ozge, A; Senol, M G; Togrol, E; Ozdag, F; Saracoglu, M; Misirli, H

    2008-01-01

    This study assessed the sensitivity of various methods for the clinical diagnosis of diabetic peripheral neuropathy. A total of 147 randomly selected patients with diabetes mellitus and 65 age- and sex-matched healthy controls were evaluated by various clinical (the neuropathy symptom score [NSS], the neuropathy disability score [NDS], vibration perception thresholds [VPTs], Tinel's sign and Phalen's sign), laboratory (fasting plasma glucose and glycosylated haemoglobin levels) and electro-physiological (nerve conduction studies, H-reflex and F-wave measurements) methods. In the patient group, 8.2% had an abnormal NSS, 28.5% had a positive Phalen's sign, 32.6% had a positive Tinel's sign, 42.8% had an abnormal VPT and 57.1% had an abnormal NDS. Significant correlations were found between electro-physiologically confirmed neuropathy and the two provocation tests and abnormal VPTs. In conclusion, assessment with a complete neurological examination and standard electrophysiological tests is very important for the diagnosis of diabetic peripheral neuropathy and the prevention of morbidity in patients with or without symptoms.

  20. Consideration of the method of image diagnosis with respect to frontal lobe atrophy

    Science.gov (United States)

    Sato, K.; Sugawara, K.; Narita, Y.; Namura, I.

    1996-12-01

    Proposes a segmentation method for a quantitative image diagnosis as a means of realizing an objective diagnosis of the frontal lobe atrophy. From the data obtained on the grade of membership, the fractal dimensions of the cerebral tissue [cerebral spinal fluid (CSF), gray matter, and white matter] and the contours are estimated. The mutual relationship between the degree of atrophy and the fractal dimension has been analyzed based on the estimated fractal dimensions. Using a sample of 42 male and female cases, ranging In age from 50's to 70's, it has been concluded that the frontal lobe atrophy can be quantified by regarding it as an expansion of CSF region on the magnetic resonance imaging (MRI) of the brain. Furthermore, when the process of frontal lobe atrophy is separated into early and advanced stages, the volumetric change of CSF and white matter in frontal lobe displays meaningful differences between the two stages, demonstrating that the fractal dimension of CSF rises with the progress of atrophy. Moreover, an interpolation method for three-dimensional (3-D) shape reconstruction of the region of diagnostic interest is proposed and 3-D shape visualization, with respect to the degree and form of atrophy, is performed on the basis of the estimated fractal dimension of the segmented cerebral tissue.

  1. An artificial neural network ensemble method for fault diagnosis of proton exchange membrane fuel cell system

    International Nuclear Information System (INIS)

    Shao, Meng; Zhu, Xin-Jian; Cao, Hong-Fei; Shen, Hai-Feng

    2014-01-01

    The commercial viability of PEMFC (proton exchange membrane fuel cell) systems depends on using effective fault diagnosis technologies in PEMFC systems. However, many researchers have experimentally studied PEMFC (proton exchange membrane fuel cell) systems without considering certain fault conditions. In this paper, an ANN (artificial neural network) ensemble method is presented that improves the stability and reliability of the PEMFC systems. In the first part, a transient model giving it flexibility in application to some exceptional conditions is built. The PEMFC dynamic model is built and simulated using MATLAB. In the second, using this model and experiments, the mechanisms of four different faults in PEMFC systems are analyzed in detail. Third, the ANN ensemble for the fault diagnosis is built and modeled. This model is trained and tested by the data. The test result shows that, compared with the previous method for fault diagnosis of PEMFC systems, the proposed fault diagnosis method has higher diagnostic rate and generalization ability. Moreover, the partial structure of this method can be altered easily, along with the change of the PEMFC systems. In general, this method for diagnosis of PEMFC has value for certain applications. - Highlights: • We analyze the principles and mechanisms of the four faults in PEMFC (proton exchange membrane fuel cell) system. • We design and model an ANN (artificial neural network) ensemble method for the fault diagnosis of PEMFC system. • This method has high diagnostic rate and strong generalization ability

  2. Evaluation of imaging methods in the diagnosis of urolithiasis: review of the literature

    International Nuclear Information System (INIS)

    Freitas, Ricardo Miguel Costa de; Silva, Luciana Costa; Santos, Jovita Lane Soares; Tavares Junior, Wilson Campos

    2004-01-01

    The aim of this study is to compare helical computed tomography with imaging studies currently used to evaluate patients with acute low back pain. In addition, we briefly review the pathophysiology of urolithiasis. The literature published in the last 30 years was reviewed, and the following methods were discussed: plain abdominal radiographs, intravenous pyelography, ultrasound of the urinary tract, and helical computed tomography. Helical computed tomography showed high sensitivity and specificity for detecting urolithiasis, virtually showing all stones, except in patients receiving indinavir. The accuracy of plain abdominal radiographs associated with ultrasound was similar to helical computed tomography, although the latter showed superiority as an isolated method. Data from literature suggest that whenever helical computed tomography is available, it is helpful in the evaluation of low back pain and also allows differential diagnosis between conditions that mimic the symptoms of urolithiasis.(author)

  3. EEMD-based multiscale ICA method for slewing bearing fault detection and diagnosis

    Science.gov (United States)

    Žvokelj, Matej; Zupan, Samo; Prebil, Ivan

    2016-05-01

    A novel multivariate and multiscale statistical process monitoring method is proposed with the aim of detecting incipient failures in large slewing bearings, where subjective influence plays a minor role. The proposed method integrates the strengths of the Independent Component Analysis (ICA) multivariate monitoring approach with the benefits of Ensemble Empirical Mode Decomposition (EEMD), which adaptively decomposes signals into different time scales and can thus cope with multiscale system dynamics. The method, which was named EEMD-based multiscale ICA (EEMD-MSICA), not only enables bearing fault detection but also offers a mechanism of multivariate signal denoising and, in combination with the Envelope Analysis (EA), a diagnostic tool. The multiscale nature of the proposed approach makes the method convenient to cope with data which emanate from bearings in complex real-world rotating machinery and frequently represent the cumulative effect of many underlying phenomena occupying different regions in the time-frequency plane. The efficiency of the proposed method was tested on simulated as well as real vibration and Acoustic Emission (AE) signals obtained through conducting an accelerated run-to-failure lifetime experiment on a purpose-built laboratory slewing bearing test stand. The ability to detect and locate the early-stage rolling-sliding contact fatigue failure of the bearing indicates that AE and vibration signals carry sufficient information on the bearing condition and that the developed EEMD-MSICA method is able to effectively extract it, thereby representing a reliable bearing fault detection and diagnosis strategy.

  4. An automated retinal imaging method for the early diagnosis of diabetic retinopathy.

    Science.gov (United States)

    Franklin, S Wilfred; Rajan, S Edward

    2013-01-01

    Diabetic retinopathy is a microvascular complication of long-term diabetes and is the major cause for eyesight loss due to changes in blood vessels of the retina. Major vision loss due to diabetic retinopathy is highly preventable with regular screening and timely intervention at the earlier stages. Retinal blood vessel segmentation methods help to identify the successive stages of such sight threatening diseases like diabetes. To develop and test a novel retinal imaging method which segments the blood vessels automatically from retinal images, which helps the ophthalmologists in the diagnosis and follow-up of diabetic retinopathy. This method segments each image pixel as vessel or nonvessel, which in turn, used for automatic recognition of the vasculature in retinal images. Retinal blood vessels were identified by means of a multilayer perceptron neural network, for which the inputs were derived from the Gabor and moment invariants-based features. Back propagation algorithm, which provides an efficient technique to change the weights in a feed forward network, is utilized in our method. Quantitative results of sensitivity, specificity and predictive values were obtained in our method and the measured accuracy of our segmentation algorithm was 95.3%, which is better than that presented by state-of-the-art approaches. The evaluation procedure used and the demonstrated effectiveness of our automated retinal imaging method proves itself as the most powerful tool to diagnose diabetic retinopathy in the earlier stages.

  5. An educational method for evaluating the resistance to the treatment in the diagnosis of dyscalculia

    Directory of Open Access Journals (Sweden)

    Giampaolo Chiappini

    2016-04-01

    Full Text Available In this paper a didactical method that has been proven effective for evaluating the “resistance to the treatment” of the student is presented. This parameter is essential for distinguishing the learning difficulties in mathematics from the learning disorder of dyscalculia. The method is based on GimmeFive, an application that has been designed to develop skills in mental calculation of multi-digit additions and subtractions. In this paper we present the results of two experiments conducted with groups of students respectively with learning difficulties in mathematics and dyscalculia. These experiments allowed to show the effectiveness of the didactical method in the evaluation of the resistance to the treatment and to discuss the features that make it adequate for the evaluation of the learning disorder. An educational method for evaluating the resistance to the treatment in the diagnosis of dyscalculiaIn questo lavoro viene presentato un metodo didattico che si è dimostrato efficace per valutare la resistenza al trattamento dello studente che è uno dei parametri fondamentali per distinguere la difficoltà di apprendimento in matematica dal disturbo di apprendimento noto come discalculia. Il metodo si basa sull’uso dell’applicazione GimmeFive che è stata progettata per sviluppare competenze nel calcolo mentale di addizioni e sottrazioni a più cifre. In questo lavoro vengono presentati risultati di due sperimentazioni condotte con gruppi di studenti rispettivamente con difficoltà di apprendimento e con diagnosi di discalculia. Queste sperimentazioni hanno consentito di mostrare l’efficacia del metodo didattico nella valutazione della resistenza al trattamento e di discutere le caratteristiche che lo rendono adeguato per la valutazione del disturbo di apprendimento.

  6. Right ventriculography as a valid method for the diagnosis of tricuspid insufficiency.

    Science.gov (United States)

    Ubago, J L; Figueroa, A; Colman, T; Ochoteco, A; Rodríguez, M; Durán, C M

    1981-01-01

    The value of right ventriculography in the diagnosis of tricuspid insufficiency (TI) is often questioned because of 1) the high incidence of premature ventricular contractions (PVCs) during injections and 2) interference of the catheter in the valve closure mechanism. In 168 patients a commercially available, not preshaped, balloon-tipped catheter was used for right ventriculography. To avoid the induction of PVCs, the catheter tip was placed in the middle third of the diafragmatic wall of the right ventricle, and the balloon was inflated, becoming trapped by the trabeculae. In this position the catheter's side holes should be located in the inflow chamber. To ensure this correct position, and therefore lack of ectopic beats during angiography, a saline test injection was performed previously in every case. With this technique the incidence of PVCs during ventriculography was only 7.7%. In all but one case, such beats were isolated. The 168 patients were divided into three groups according to their likelihood of experiencing tricuspid interference by the catheter: group 1 included 41 patients with a normal heart or with coronary artery disease. No one from this group had TI. Of group II, 28 patients with right ventricular pressure or volume overload or cardiomyopathy, only 2 had TI, both with a previous clinical diagnosis of regurgitation. Group III contained 99 patients with rheumatic heart disease. Thirty-five of them showed angiographic TI, and 24 of these had this diagnosis confirmed either clinically or at surgery. It is felt that this technique of right ventriculography, with its low incidence of PVCs and slight interference with tricuspid closure, is a valid method for the objective study of the tricuspid valve.

  7. Clinical, laboratory and instrumental methods of pre-surgical diagnosis of the parathyroid glands cancer

    Directory of Open Access Journals (Sweden)

    Natalia G. Mokrysheva

    2017-12-01

    Full Text Available Backgraund. When defining symptomatic primary hyperparathyroidism (PHPT, differential diagnosis between a benign and malignant neoplasm of parathyroid glands (PG may be challenging. The diagnosis of carcinoma or a benign tumor determines the extent of the surgical intervention and further observation tactics. Aims. The purpose of the study is to determine the clinical and laboratory and instrumental predictors of PG cancer. Materials and methods. A retrospective study included 385 patients with PHPT (273 with adenomas of the PG, 66 with hyperplasia, and 19 patients with cancer of the PG, who had been examined and operated from 2000 to 2014. The primary goal of the study was to define the level of ionized calcium (Ca++, parathyroid hormone (PTH, and the volume of the tumor PG specific for cancer of the PG. The level of parathyroid hormone (PTH was determined by electrochemoluminescent method on the Roche analyzer Cobas 6000; ionized calcium (Ca++ ion-selective method. The size of the PG was determined by the ellipse formula: V(cm3 = (A × B × C × 0.49 by ultrasound investigation using the Valuson E8 device from General Electric. Results. The group of patients with PG carcinoma showed the increased level of Ca++ of more than 1.60 mmol/l (p = 0.004 and increased level of PTH of more than 600 pg/ml (p = 0.03. The size of tumors of more than 6 cm3 is more typical to malignant neoplasm compared to the adenoma of the PG (p = 0.01. Conclusions. The group of patients with PHPT that are at risk of having PG carcinoma include individuals that have a combination of the following indicators: PTH levels of more than 600 pg/ml, an increase in ionized calcium of more than 1.60 mmol/l, the tumor size of more than 6 cm3.

  8. Valuation In The Constitutional Era

    Directory of Open Access Journals (Sweden)

    Elmien du Plessis

    2015-12-01

    Full Text Available The Constitution brought about a new compensation regime for expropriations. Compensation for expropriation must now be "just and equitable". Whereas before the Constitution came into force market value played a central role in compensation for expropriation, market value is now only one factor or aspect of compensation that the court needs to take into account. Yet we find that courts tend to focus on market value and to still employ the valuation methods used to calculate market value. This article argues that the methods used to calculate the market value, once thought to be objective, are not as objective as was believed. While it is impossible to give judges specific tools for the assessment of market value, this article provides guidelines on how the calculation of compensation should be approached.

  9. Automated image processing method for the diagnosis and classification of malaria on thin blood smears.

    Science.gov (United States)

    Ross, Nicholas E; Pritchard, Charles J; Rubin, David M; Dusé, Adriano G

    2006-05-01

    Malaria is a serious global health problem, and rapid, accurate diagnosis is required to control the disease. An image processing algorithm to automate the diagnosis of malaria on thin blood smears is developed. The image classification system is designed to positively identify malaria parasites present in thin blood smears, and differentiate the species of malaria. Images are acquired using a charge-coupled device camera connected to a light microscope. Morphological and novel threshold selection techniques are used to identify erythrocytes (red blood cells) and possible parasites present on microscopic slides. Image features based on colour, texture and the geometry of the cells and parasites are generated, as well as features that make use of a priori knowledge of the classification problem and mimic features used by human technicians. A two-stage tree classifier using backpropogation feedforward neural networks distinguishes between true and false positives, and then diagnoses the species (Plasmodium falciparum, P. vivax, P. ovale or P. malariae) of the infection. Malaria samples obtained from the Department of Clinical Microbiology and Infectious Diseases at the University of the Witwatersrand Medical School are used for training and testing of the system. Infected erythrocytes are positively identified with a sensitivity of 85% and a positive predictive value (PPV) of 81%, which makes the method highly sensitive at diagnosing a complete sample provided many views are analysed. Species were correctly determined for 11 out of 15 samples.

  10. Applied Ecosystem Analysis - Background EDT - The Ecosystem Diagnosis and Treatment Method

    International Nuclear Information System (INIS)

    Mobrand, L.E.; Lichatowich, J.A.; Howard, D.A.; Vogel, T.S.

    1996-05-01

    This volume consists of eight separate reports. We present them as background to the Ecosystem Diagnosis and Treatment (EDT) methodology. They are a selection from publications, white papers, and presentations prepared over the past two years. Some of the papers are previously published, others are currently being prepared for publication. In the early to mid 1980's the concern for failure of both natural and hatchery production of Columbia river salmon populations was widespread. The concept of supplementation was proposed as an alternative solution that would integrate artificial propagation with natural production. In response to the growing expectations placed upon the supplementation tool, a project called Regional Assessment of Supplementation Project (RASP) was initiated in 1990. The charge of RASP was to define supplementation and to develop guidelines for when, where and how it would be the appropriate solution to salmon enhancement in the Columbia basin. The RASP developed a definition of supplementation and a set of guidelines for planning salmon enhancement efforts which required consideration of all factors affecting salmon populations, including environmental, genetic, and ecological variables. The results of RASP led to a conclusion that salmon issues needed to be addressed in a manner that was consistent with an ecosystem approach. If the limitations and potentials of supplementation or any other management tool were to be fully understood it would have to be within the context of a broadly integrated approach - thus the Ecosystem Diagnosis and Treatment (EDT) method was born

  11. Comparison of visceral fat with computed tomography and other obesity diagnosis methods

    International Nuclear Information System (INIS)

    Kawasaki, Yoshiyuki; Takada, Koichiro; Shinozaki, Kumiko; Sukegawa, Kazuya; Watanabe, Nozomi; Kobayashi, Toshimitsu; Sato, Kazuhiko; Imura, Hitoshi

    2006-01-01

    The metabolic syndrome is closely associated with coronary artery disease, and the syndrome is suggested to be based on visceral fat accumulation. Therefore, estimating the amount of visceral fat is important. There is such a background, and institutions enforcing measurement system for visceral fat with computed tomography increase. However, many institutions are diagnosing the obesity in body mass index or %FAT. Therefore, we compared it with visceral fat about other obesity diagnosis methods. We have developed this time a software program that allows automated analysis of computed tomography (CT) image as well as measurement of area of visceral fat, area of subcutaneous fat and abdominal circumference. With this software, we examined 7369 patients who analyzed it in February 2005 from September 2003. An examination item is a coefficient of correlation, sensitivity, specificity, cut-off value. As a result, it was waist that visceral fat and correlation were high. Visceral fat correlation were high in body mass index (BMI) and %FAT, but were not able to satisfy sensitivity and specificity. It is reported that the measurement of visceral fat is effective for a diagnosis of obesity. However, we want to recommend the measurement of waist in such an institution because cannot do it in all institutions. (author)

  12. A cephalometric method to diagnosis the craniovertebral junction abnormalities in osteogenesis imperfecta patients

    Science.gov (United States)

    Ríos-Rodenas, Mercedes; Gutiérrez-Díez, María-Pilar; Feijóo, Gonzalo; Mourelle, Maria-Rosa; Garcilazo, Mario; Ortega-Aranegui, Ricardo

    2015-01-01

    Osteogenesis imperfecta (OI) is a hereditary bone fragility disorder that in most patients is caused by mutations affecting collagen type I. Their typical oral and craneofacial characteristics (Dentinogenesis imperfecta type I and class III malocclusion), involve the dentist in the multidisciplinary team that treat these patients. It is usual to perform lateral skull radiographs for the orthodontic diagnosis. In addition, this radiograph is useful to analyse the junctional area between skull base and spine, that could be damaged in OI. Pathology in the craneovertebral junction (CVJ) is a serious complication of OI with a prevalence ranging from rare to 37%. To diagnosis early skull base anomalies in these patients, previously the neurological symptoms have been appear, we make a simple cephalometric analysis of the CVJ. This method has four measurements and one angle. Once we calculate the values of the OI patient, we compare the result with the mean and the standard deviations of an age-appropriate average in healthy controls. If the patient has a result more than 2,5 SDs above the age-appropriate average in healthy controls, we should to refer the patient to his/her pediatrician or neurologist. These doctors have to consider acquiring another diagnostic images to be used to determine cranial base measurements with more reliability. Thereby, dentists who treat these patients, must be aware of the normal radiological anatomy of the cervical spine on the lateral cephalogram. Key words:Osteogenesis imperfecta, craniovertebral junction, cephalometric. PMID:25810828

  13. Applied Ecosystem Analysis - Background : EDT the Ecosystem Diagnosis and Treatment Method.

    Energy Technology Data Exchange (ETDEWEB)

    Mobrand, Lars E.

    1996-05-01

    This volume consists of eight separate reports. We present them as background to the Ecosystem Diagnosis and Treatment (EDT) methodology. They are a selection from publications, white papers, and presentations prepared over the past two years. Some of the papers are previously published, others are currently being prepared for publication. In the early to mid 1980`s the concern for failure of both natural and hatchery production of Columbia river salmon populations was widespread. The concept of supplementation was proposed as an alternative solution that would integrate artificial propagation with natural production. In response to the growing expectations placed upon the supplementation tool, a project called Regional Assessment of Supplementation Project (RASP) was initiated in 1990. The charge of RASP was to define supplementation and to develop guidelines for when, where and how it would be the appropriate solution to salmon enhancement in the Columbia basin. The RASP developed a definition of supplementation and a set of guidelines for planning salmon enhancement efforts which required consideration of all factors affecting salmon populations, including environmental, genetic, and ecological variables. The results of RASP led to a conclusion that salmon issues needed to be addressed in a manner that was consistent with an ecosystem approach. If the limitations and potentials of supplementation or any other management tool were to be fully understood it would have to be within the context of a broadly integrated approach - thus the Ecosystem Diagnosis and Treatment (EDT) method was born.

  14. A Method for Aileron Actuator Fault Diagnosis Based on PCA and PGC-SVM

    Directory of Open Access Journals (Sweden)

    Wei-Li Qin

    2016-01-01

    Full Text Available Aileron actuators are pivotal components for aircraft flight control system. Thus, the fault diagnosis of aileron actuators is vital in the enhancement of the reliability and fault tolerant capability. This paper presents an aileron actuator fault diagnosis approach combining principal component analysis (PCA, grid search (GS, 10-fold cross validation (CV, and one-versus-one support vector machine (SVM. This method is referred to as PGC-SVM and utilizes the direct drive valve input, force motor current, and displacement feedback signal to realize fault detection and location. First, several common faults of aileron actuators, which include force motor coil break, sensor coil break, cylinder leakage, and amplifier gain reduction, are extracted from the fault quadrantal diagram; the corresponding fault mechanisms are analyzed. Second, the data feature extraction is performed with dimension reduction using PCA. Finally, the GS and CV algorithms are employed to train a one-versus-one SVM for fault classification, thus obtaining the optimal model parameters and assuring the generalization of the trained SVM, respectively. To verify the effectiveness of the proposed approach, four types of faults are introduced into the simulation model established by AMESim and Simulink. The results demonstrate its desirable diagnostic performance which outperforms that of the traditional SVM by comparison.

  15. Discrimination method of large log-likelihood study in differential diagnosis of pulmonary diffuse mild micro-nodule

    International Nuclear Information System (INIS)

    Chen Budong; Ma Daqing; He Wen; Tang Hongqu; Qian Linxue; Zhou Ronglin

    2001-01-01

    Objective: To analyze HRCT and thin-slice CT scan findings in 150 patients with pulmonary diffuse mild micro-nodule, and to find the features with the purpose of identifying random micro-nodule, peri-lymphatic micro-nodule, and centrilobular micro-nodule. Methods: The useful features i 150 patients with pulmonary diffuse mild micro-nodule were translated into scores by means of discrimination method of large log-likelihood to identify the micro-nodular category. Results: The accuracy of diagnosis was 94.0% for random micro-nodule, 76.0% for peri-lymphatic micro-nodule, and 90.0% for centrilobular micro-nodule. Conclusion: HRCT and thin-slice CT scans were helpful in differential diagnosis of pulmonary diffuse mild micro-nodule. The discrimination method of large log-likelihood was propitious to diagnosis and differential diagnosis

  16. Model-Based Methods for Fault Diagnosis: Some Guide-Lines

    DEFF Research Database (Denmark)

    Patton, R.J.; Chen, J.; Nielsen, S.B.

    1995-01-01

    This paper provides a review of model-based fault diagnosis techniques. Starting from basic principles, the properties.......This paper provides a review of model-based fault diagnosis techniques. Starting from basic principles, the properties....

  17. Crushed Salt Constitutive Model

    International Nuclear Information System (INIS)

    Callahan, G.D.

    1999-01-01

    The constitutive model used to describe the deformation of crushed salt is presented in this report. Two mechanisms -- dislocation creep and grain boundary diffusional pressure solution -- are combined to form the basis for the constitutive model governing the deformation of crushed salt. The constitutive model is generalized to represent three-dimensional states of stress. Upon complete consolidation, the crushed-salt model reproduces the Multimechanism Deformation (M-D) model typically used for the Waste Isolation Pilot Plant (WIPP) host geological formation salt. New shear consolidation tests are combined with an existing database that includes hydrostatic consolidation and shear consolidation tests conducted on WIPP and southeastern New Mexico salt. Nonlinear least-squares model fitting to the database produced two sets of material parameter values for the model -- one for the shear consolidation tests and one for a combination of the shear and hydrostatic consolidation tests. Using the parameter values determined from the fitted database, the constitutive model is validated against constant strain-rate tests. Shaft seal problems are analyzed to demonstrate model-predicted consolidation of the shaft seal crushed-salt component. Based on the fitting statistics, the ability of the model to predict the test data, and the ability of the model to predict load paths and test data outside of the fitted database, the model appears to capture the creep consolidation behavior of crushed salt reasonably well

  18. Communicative Constitution of Organizations

    DEFF Research Database (Denmark)

    Schoeneborn, Dennis; Vasquez, Consuelo

    2017-01-01

    The notion of the communicative constitution of organizations (CCO) is at the center of a growing theoretical development within organizational communication studies. CCO scholarship is based on the idea that organization emerges in and is sustained and transformed by communication. This entry...

  19. Gender and the Constitution

    Science.gov (United States)

    Ginsburg, Ruth Bader

    1975-01-01

    In discussing the constitutional aspects of the sex-role debate in the U.S. the author traces the tradition, compares the present criterion of equal protection to the equal rights argument, and analyzes the equality principle with reference to affirmative action and to childbearing and childrearing, supporting the proposed equal rights amendment.…

  20. constitutional adjudication in ethiopia

    African Journals Online (AJOL)

    eliasn

    2000-01-25

    Jan 25, 2000 ... Thus the seeds of what some authors call. “federal .... Pre-WWII Europe trusted its legislature and led to .... European and Civil Law Forum v. 11 ...... on the sovereignty of nationalities and the fact that language constitutes one.

  1. The constitutive sofa cushion

    DEFF Research Database (Denmark)

    Hanghøj, Sara

    2009-01-01

    personal values materialize through a hand-made everyday artefact, and how can the artefact constitute action and self-perception? The empirical research and analysis concerns how a former textile crafts teacher's subjective values and professional identity materialize through a hand-woven sofa cushion...

  2. A Prospect and Challenges for Adopting Constitutional Complaint and Constitutional Question in the Indonesian Constitutional Court

    OpenAIRE

    Faiz, Pan Mohamad

    2016-01-01

    A jurisdiction of the Indonesian Constitutional Court concerning constitutional adjudication is only limited to review the constitutionality of national law. There is no mechanism for challenging any decision or action made by public authorities that violate fundamental rights enshrined in the Indonesian Constitution. This article argues that constitutional complaint and constitutional question might be adopted as new jurisdictions of the Indonesian Constitutional Court in order to strengthen...

  3. Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis

    Directory of Open Access Journals (Sweden)

    Antti Cajanus

    2018-02-01

    Full Text Available Aims: We assessed the value of automated MRI quantification methods in the differential diagnosis of behavioral-variant frontotemporal dementia (bvFTD from Alzheimer disease (AD, Lewy body dementia (LBD, and subjective memory complaints (SMC. We also examined the role of the C9ORF72-related genetic status in the differentiation sensitivity. Methods: The MRI scans of 50 patients with bvFTD (17 C9ORF72 expansion carriers were analyzed using 6 quantification methods as follows: voxel-based morphometry (VBM, tensor-based morphometry, volumetry (VOL, manifold learning, grading, and white-matter hyperintensities. Each patient was then individually compared to an independent reference group in order to attain diagnostic suggestions. Results: Only VBM and VOL showed utility in correctly identifying bvFTD from our set of data. The overall classification sensitivity of bvFTD with VOL + VBM achieved a total sensitivity of 60%. Using VOL + VBM, 32% were misclassified as having LBD. There was a trend of higher values for classification sensitivity of the C9ORF72 expansion carriers than noncarriers. Conclusion: VOL, VBM, and their combination are effective in differential diagnostics between bvFTD and AD or SMC. However, MRI atrophy profiles for bvFTD and LBD are too similar for a reliable differentiation with the quantification methods tested in this study.

  4. Stator and Rotor Faults Diagnosis of Squirrel Cage Motor Based on Fundamental Component Extraction Method

    Directory of Open Access Journals (Sweden)

    Guoqing An

    2017-01-01

    Full Text Available Nowadays, stator current analysis used for detecting the incipient fault in squirrel cage motor has received much attention. However, in the case of interturn short circuit in stator, the traditional symmetrical component method has lost the precondition due to the harmonics and noise; the negative sequence component (NSC is hard to be obtained accurately. For broken rotor bars, the new added fault feature blanked by fundamental component is also difficult to be discriminated in the current spectrum. To solve the above problems, a fundamental component extraction (FCE method is proposed in this paper. On one hand, via the antisynchronous speed coordinate (ASC transformation, NSC of extracted signals is transformed into the DC value. The amplitude of synthetic vector of NSC is used to evaluate the severity of stator fault. On the other hand, the extracted fundamental component can be filtered out to make the rotor fault feature emerge from the stator current spectrum. Experiment results indicate that this method is feasible and effective in both interturn short circuit and broken rotor bars fault diagnosis. Furthermore, only stator currents and voltage frequency are needed to be recorded, and this method is easy to implement.

  5. A pre-trained convolutional neural network based method for thyroid nodule diagnosis.

    Science.gov (United States)

    Ma, Jinlian; Wu, Fa; Zhu, Jiang; Xu, Dong; Kong, Dexing

    2017-01-01

    In ultrasound images, most thyroid nodules are in heterogeneous appearances with various internal components and also have vague boundaries, so it is difficult for physicians to discriminate malignant thyroid nodules from benign ones. In this study, we propose a hybrid method for thyroid nodule diagnosis, which is a fusion of two pre-trained convolutional neural networks (CNNs) with different convolutional layers and fully-connected layers. Firstly, the two networks pre-trained with ImageNet database are separately trained. Secondly, we fuse feature maps learned by trained convolutional filters, pooling and normalization operations of the two CNNs. Finally, with the fused feature maps, a softmax classifier is used to diagnose thyroid nodules. The proposed method is validated on 15,000 ultrasound images collected from two local hospitals. Experiment results show that the proposed CNN based methods can accurately and effectively diagnose thyroid nodules. In addition, the fusion of the two CNN based models lead to significant performance improvement, with an accuracy of 83.02%±0.72%. These demonstrate the potential clinical applications of this method. Copyright © 2016 Elsevier B.V. All rights reserved.

  6. Fault diagnosis of rolling element bearing using a new optimal scale morphology analysis method.

    Science.gov (United States)

    Yan, Xiaoan; Jia, Minping; Zhang, Wan; Zhu, Lin

    2018-02-01

    Periodic transient impulses are key indicators of rolling element bearing defects. Efficient acquisition of impact impulses concerned with the defects is of much concern to the precise detection of bearing defects. However, transient features of rolling element bearing are generally immersed in stochastic noise and harmonic interference. Therefore, in this paper, a new optimal scale morphology analysis method, named adaptive multiscale combination morphological filter-hat transform (AMCMFH), is proposed for rolling element bearing fault diagnosis, which can both reduce stochastic noise and reserve signal details. In this method, firstly, an adaptive selection strategy based on the feature energy factor (FEF) is introduced to determine the optimal structuring element (SE) scale of multiscale combination morphological filter-hat transform (MCMFH). Subsequently, MCMFH containing the optimal SE scale is applied to obtain the impulse components from the bearing vibration signal. Finally, fault types of bearing are confirmed by extracting the defective frequency from envelope spectrum of the impulse components. The validity of the proposed method is verified through the simulated analysis and bearing vibration data derived from the laboratory bench. Results indicate that the proposed method has a good capability to recognize localized faults appeared on rolling element bearing from vibration signal. The study supplies a novel technique for the detection of faulty bearing. Copyright © 2018. Published by Elsevier Ltd.

  7. A novel relational regularization feature selection method for joint regression and classification in AD diagnosis.

    Science.gov (United States)

    Zhu, Xiaofeng; Suk, Heung-Il; Wang, Li; Lee, Seong-Whan; Shen, Dinggang

    2017-05-01

    In this paper, we focus on joint regression and classification for Alzheimer's disease diagnosis and propose a new feature selection method by embedding the relational information inherent in the observations into a sparse multi-task learning framework. Specifically, the relational information includes three kinds of relationships (such as feature-feature relation, response-response relation, and sample-sample relation), for preserving three kinds of the similarity, such as for the features, the response variables, and the samples, respectively. To conduct feature selection, we first formulate the objective function by imposing these three relational characteristics along with an ℓ 2,1 -norm regularization term, and further propose a computationally efficient algorithm to optimize the proposed objective function. With the dimension-reduced data, we train two support vector regression models to predict the clinical scores of ADAS-Cog and MMSE, respectively, and also a support vector classification model to determine the clinical label. We conducted extensive experiments on the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset to validate the effectiveness of the proposed method. Our experimental results showed the efficacy of the proposed method in enhancing the performances of both clinical scores prediction and disease status identification, compared to the state-of-the-art methods. Copyright © 2015 Elsevier B.V. All rights reserved.

  8. 201thallium myocardial scintigraphy. A non-invasive method for diagnosis of ischaemic heart disease

    International Nuclear Information System (INIS)

    Kyst Madsen, J.; Utne, H.E.

    1982-01-01

    Myocardial perfusion scintigraphy with the isotope 201 thallium is a new non-invasive technique for the diagnosis of ischaemic heart disease. This article presents the results of scintigraphy in four persons with presumably healthy hearts and 12 with ischaemic heart disease. In addition, some foreign works are reviewed. The method possesses only slightly greater nosographical sensitivity than the exercise ECG alone but can be employed to advantage if the results of the exercise ECG are inconclusive e.g. on account of bundle branch block, digoxin therapy etc. Another, although somewhat more special indication, is employment prior to and after coronary artery by-pass operation with subsequent control of the result. (authors)

  9. Radionuclide visualization of uterin fibromyoma as a new method of differential diagnosis

    International Nuclear Information System (INIS)

    Kalantarov, K.D.; Ashikhmina, I.G.; Juokov, V.A.

    1982-01-01

    Since fibromateous uterus is very vascularized, it is very promising to visualize this blood pool by using radionuclide technique. The study consists of 30 patients with fibromyoma, cyst and other diseases of genital system (salpingitis, ooforit etc.). Blood pool labeling was performed by ''in vivo'' labeling of red blood cells (chlorous tin injection followed by pertechnetate administration) or by intravenous injection of serum albumin labelled with Tc-99m. Both methods were found satisfactory. Gammacamera GKS-I (Soviet production) connected with data store and processing system (CINE-200) was positioned over region of uterus, radioactivity injected and data collected as dynamic study at I frame/sec during 60 seconds. Static visualization was performed 30 min after dynamic study. Radionuclide visualization can be considered as reliable and non-invasive tool in differential diagnosis of fibromyoma and cyst of uterus as well as of endometritis

  10. Carbogen Enhanced Femto Oximetry Breast Cancer Diagnosis Method with High Specificity

    Science.gov (United States)

    Maglich, Bogdan C.; Shultis, J. K.; Solomon, C. J.

    2011-03-01

    As large malignant tumors are oxygen deficient (hypoxic), cancer could be diagnosed in vivo and online, by non-invasive measurement of oxygen difference between tumor and adjacent tissue. Computer simulations of noninvasive diagnosis by Femto Oximetry (FO) of hypoxia in 1 cm tumor in 10 cm breast shows that background γ 's from non hypoxic tissue will mask hypoxia. To amplify the hypoxic-to-normal O difference, air breathing will be replaced with carbogen (O2 95 % , CO2 5 %) using vasco-constrictive property whereby carbogen breathing increases O in normal tissue, while not in malignant hypoxic tumors. 90% hypoxia will be detectable by FO with specificity 99%. Our method will be tested on R3230 tumors in Fischer rats at UCI.

  11. Implementation of Segmentation Methods for the Diagnosis and Prognosis of Mild Cognitive Impairment and Alzheimer Disease

    International Nuclear Information System (INIS)

    Matoug, S; Abdel-Dayem, A

    2012-01-01

    Alzheimer's disease (AD) is the most common form of dementia affecting seniors age 65 and over. When AD is suspected, the diagnosis is usually confirmed with behavioural assessments and cognitive tests, often followed by a brain scan. Advanced medical imaging is a good tool to predict conversion from prodromal stages (mild cognitive impairment) to Alzheimer's disease. Since volumetric MRI can detect changes in the size of brain regions, measuring those regions that atrophy during the progress of Alzheimer's disease can help the neurologist in his diagnostic. In the present investigation, we present an automatic tool that reads volumetric MRI and performs 2-dimensional (volume slices) and volumetric segmentation methods in order to segment gray matter, white matter and cerebrospinal fluid (CSF). We used the MRI data sets database from the Open Access Series of Imaging Studies (OASIS).

  12. Diagnosis of porcine enzootic pneumonia by post mortem sanitary inspection: comparison with other diagnostic methods

    OpenAIRE

    Kênia de Fátima Carrijo; Elmiro Rosendo do Nascimento; Virginia Léo de Almeida Pereira; Nelson Morés; Catia Silene Klein; Leonardo Muliterno Domingues; Rogerio Tortelly

    2014-01-01

    ABSTRACT. Carrijo K.F., Nascimento E.R., Pereira V.L.A., Morés N., Klein, C.S., Domingues L.M. & Tortelly R. [Diagnosis of porcine enzootic pneumonia by post mortem sanitary inspection: comparison with other diagnostic methods.] Diagnóstico da pneumonia enzoótica suína pela inspeção sanitária post mortem: comparação com outros métodos de diagnóstico. Revista Brasileira de Veterinária Brasileira 36(2):188-194, 2014. Faculdade de Medicina Veterinária, Universidade Federal de Uberlândia, Av. Par...

  13. Fault Diagnosis of Demountable Disk-Drum Aero-Engine Rotor Using Customized Multiwavelet Method

    Directory of Open Access Journals (Sweden)

    Jinglong Chen

    2015-10-01

    Full Text Available The demountable disk-drum aero-engine rotor is an important piece of equipment that greatly impacts the safe operation of aircraft. However, assembly looseness or crack fault has led to several unscheduled breakdowns and serious accidents. Thus, condition monitoring and fault diagnosis technique are required for identifying abnormal conditions. Customized ensemble multiwavelet method for aero-engine rotor condition identification, using measured vibration data, is developed in this paper. First, customized multiwavelet basis function with strong adaptivity is constructed via symmetric multiwavelet lifting scheme. Then vibration signal is processed by customized ensemble multiwavelet transform. Next, normalized information entropy of multiwavelet decomposition coefficients is computed to directly reflect and evaluate the condition. The proposed approach is first applied to fault detection of an experimental aero-engine rotor. Finally, the proposed approach is used in an engineering application, where it successfully identified the crack fault of a demountable disk-drum aero-engine rotor. The results show that the proposed method possesses excellent performance in fault detection of aero-engine rotor. Moreover, the robustness of the multiwavelet method against noise is also tested and verified by simulation and field experiments.

  14. [Concordance between the zinc sulphate flotation and centrifugal sedimentation methods for the diagnosis of intestinal parasites].

    Science.gov (United States)

    Inês, Elizabete De Jesus; Pacheco, Flavia Thamiris Figueiredo; Pinto, Milena Carneiro; Mendes, Patrícia Silva de Almeida; Da Costa-Ribeiro, Hugo; Soares, Neci Matos; Teixeira, Márcia Cristina Aquino

    2016-12-01

    The diagnosis of intestinal parasitic infections depends on the parasite load, the specific gravity density of the parasite eggs, oocysts or cysts, and the density and viscosity of flotation or sedimentation medium where faeces are processed. To evaluate the concordance between zinc sulphate flotation and centrifugal sedimentation in the recovery of parasites in faecal samples of children. Faecal samples of 330 children from day care centers were evaluated by zinc sulphate flotation and centrifugal sedimentation techniques. The frequencies of detection of parasites by each method were determined and the agreement between the diagnostic techniques was evaluated using the kappa index, with 95% confidence intervals. The faecal flotation in zinc sulphate diagnosed significantly more cases of Trichuris trichiura infection when compared to centrifugal sedimentation (39/330; 11.8% vs. 13/330; 3.9%, p<0.001), with low diagnostic concordance between methods (kappa=0.264; 95% CI: 0.102-0.427). Moreover, all positive samples for Enterobius vermicularis eggs (n=5) and Strongyloides stercoralis larvae (n=3) were diagnosed only by zinc sulphate. No statistical differences were observed between methods for protozoa identification. The results showed that centrifugal flotation in zinc sulphate solution was significantly more likely to detect light helminths eggs such as those of T. trichiura and E. vermicularis in faeces than the centrifugal sedimentation process.

  15. A Roller Bearing Fault Diagnosis Method Based on LCD Energy Entropy and ACROA-SVM

    Directory of Open Access Journals (Sweden)

    HungLinh Ao

    2014-01-01

    Full Text Available This study investigates a novel method for roller bearing fault diagnosis based on local characteristic-scale decomposition (LCD energy entropy, together with a support vector machine designed using an Artificial Chemical Reaction Optimisation Algorithm, referred to as an ACROA-SVM. First, the original acceleration vibration signals are decomposed into intrinsic scale components (ISCs. Second, the concept of LCD energy entropy is introduced. Third, the energy features extracted from a number of ISCs that contain the most dominant fault information serve as input vectors for the support vector machine classifier. Finally, the ACROA-SVM classifier is proposed to recognize the faulty roller bearing pattern. The analysis of roller bearing signals with inner-race and outer-race faults shows that the diagnostic approach based on the ACROA-SVM and using LCD to extract the energy levels of the various frequency bands as features can identify roller bearing fault patterns accurately and effectively. The proposed method is superior to approaches based on Empirical Mode Decomposition method and requires less time.

  16. What constitutes information integrity?

    Directory of Open Access Journals (Sweden)

    S. Flowerday

    2008-01-01

    Full Text Available This research focused on what constitutes information integrity as this is a problem facing companies today. Moreover, information integrity is a pillar of information security and is required in order to have a sound security management programme. However, it is acknowledged that 100% information integrity is not currently achievable due to various limitations and therefore the auditing concept of reasonable assurance is adopted. This is in line with the concept that 100% information security is not achievable and the notion that adequate security is the goal, using appropriate countermeasures. The main contribution of this article is to illustrate the importance of and provide a macro view of what constitutes information integrity. The findings are in harmony with Samuel Johnson's words (1751: 'Integrity without knowledge is weak and useless, and knowledge without integrity is dangerous and dreadful.'

  17. What constitutes information integrity?

    Directory of Open Access Journals (Sweden)

    S. Flowerday

    2007-12-01

    Full Text Available This research focused on what constitutes information integrity as this is a problem facing companies today. Moreover, information integrity is a pillar of information security and is required in order to have a sound security management programme. However, it is acknowledged that 100% information integrity is not currently achievable due to various limitations and therefore the auditing concept of reasonable assurance is adopted. This is in line with the concept that 100% information security is not achievable and the notion that adequate security is the goal, using appropriate countermeasures. The main contribution of this article is to illustrate the importance of and provide a macro view of what constitutes information integrity. The findings are in harmony with Samuel Johnson's words (1751: 'Integrity without knowledge is weak and useless, and knowledge without integrity is dangerous and dreadful.'

  18. The constitutional view

    Directory of Open Access Journals (Sweden)

    Roberto Horácio Sá Pereira

    2016-05-01

    Full Text Available http://dx.doi.org/10.5007/1808-1711.2016v20n2p165   This brief paper is devoted to criticizing the widespread reading of Kant’s first Critique, according to which reference to subject-independent objects is “constituted” by higherorder cognitive abilities (concepts. Let us call this the “constitutional view”. In this paper, I argue that the constitutional reading confuses the un-Kantian problem of how we come to represent objects (which I call the intentionality thesis, with the quite different problem of how we cognize (erkennen (which I call the “cognition thesis” that we do represent objects, that is, things that exist independently of the subject.

  19. Transnational Governance and Constitutionalism

    DEFF Research Database (Denmark)

    Joerges, Christian; Sand, Inger-Johanne; Teubner, Gunther

    of democratic governance. The book refers to this term as a yardstick to which then contributors feel committed even where they plead for a reconceptualisation of constitutionalism or a discussion of its functional equivalents. 'Transnational governance' is neither public nor private, nor purely international......The term transnational governance designates untraditional types of international and regional collaboration among both public and private actors. These legally-structured or less formal arrangements link economic, scientific and technological spheres with political and legal processes...

  20. A human reliability analysis (HRA) method for identifying and assessing the error of commission (EOC) from a diagnosis failure

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae Whan; Jung, Won Dea; Park, Jin Yun; Kang, Dae Il

    2005-01-01

    The study deals with a method for systematically identifying and assessing the EOC events that might be caused from a diagnosis failure or misdiagnosis of the expected events in accident scenarios of nuclear power plants. The method for EOC identification and assessment consists of three steps: analysis of the potential for a diagnosis failure (or misdiagnosis), identification of the EOC events from the diagnosis failure, quantitative assessment of the identified EOC events. As a tool for analysing a diagnosis failure, the MisDiagnosis Tree Analysis (MDTA) technique is proposed with the taxonomy of misdiagnosis causes. Also, the guidance on the identification of EOC events and the classification system and data are given for quantitiative assessment. As an applicaton of the proposed method, the EOCs identification and assessment for Younggwang 3 and 4 plants and their impact on the plant risk were performed. As the result, six events or event sequences were considered for diagnosis failures and about 20 new Human Failure Events (HFEs) involving EOCs were identified. According to the assessment of the risk impact of the identified HFEs, they increase the CDF by 11.4 % of the current CDF value, which corresponds to 10.2 % of the new CDF. The small loss of coolant accident (SLOCA) turned out to be a major contributor to the increase of CDF resulting in 9.2 % increaseof the current CDF.

  1. The method of diagnosis and classification of the gingival line defects of the teeth hard tissues

    Directory of Open Access Journals (Sweden)

    Olena Bulbuk

    2017-06-01

    Full Text Available For solving the problem of diagnosis and treatment of hard tissue defects the significant role belongs to the choice of tactics for dental treatment of hard tissue defects located in the gingival line of any tooth. This work aims to study the problems of diagnosis and classification of gingival line defects of the teeth hard tissues. That will contribute to the objectification of differentiated diagnostic and therapeutic approaches in the dental treatment of various clinical variants of these defects localization. The objective of the study – is to develop the anatomical-functional classification for differentiated estimation of hard tissue defects in the gingival part, as the basis for the application of differential diagnostic-therapeutic approaches to the dental treatment of hard tissue defects disposed in the gingival part of any tooth. Materials and methods of investigation: There was conducted the examination of 48 patients with hard tissue defects located in the gingival part of any tooth. To assess the magnitude of gingival line destruction the periodontal probe and X-ray examination were used. Results. The result of the performed research the classification of the gingival line defects of the hard tissues was offered using exponent power. The value of this indicator is equal to an integer number expressed in millimeters of distance from the epithelial attachment to the cavity’s bottom of defect. Conclusions. The proposed classification fills an obvious gap in academic representations about hard tissue defects located in the gingival part of any tooth. Also it offers the prospects of consensus on differentiated diagnostic-therapeutic approaches in different clinical variants of location.  This classification builds methodological “bridge of continuity” between therapeutic and prosthetic dentistry in the field of treatment of the gingival line defects of dental hard tissues.

  2. An implementation of the diagnosis method DYANA, applied to a combined heat-power device

    Energy Technology Data Exchange (ETDEWEB)

    Van der Neut, F.

    1993-10-01

    The development and implementation of the monitor-and-diagnosis method DYANA is presented. This implementation is applied to and tested on a combined heat and power generating device (CHP). The steps that have been taken in realizing this implementation are evaluated into detail . In chapter two the theory behind DYANA is recapitulated. Attention is paid to the basic theory of diagnoses, and the steps of the path from this theory to the algorithm DYANA are revealed. These steps include the hierarchical approach, and explain the following features of DYANA: a) the use of best-first dynamic model zooming based on heuristics with respect to parsimony of the number of components within the diagnoses, b) the use of consistency of fault models with observations to focus on the most likely diagnoses, and c) the use of online diagnosis: the current set of diagnoses is incrementally updated after a new observation of the system is made. In chapter three the relevant aspects of the system to be diagnosed, the CHP, are dealt with in detail. An explanation is given of the broad working of the CHP, its hierarchical structure and mathematical representation are given, CHP observation is commented, and some possible forms of fault models are stated. In chapter four the pseudocode of the implementation, developed for DYANA, is presented. The pseudocode consists of two parts: the monitoring process (using numerical simulation), and the diagnostic process. The differences between the pseudocode and the actual implementation are mentioned. The CHP will then be monitored and diagnosed with this algorithm and results of this test are given in chapter five. An actual implementation of DYANA can be found in a separately supplied appendix, the Programme Appendix. The implementation of the monitoring process is meant only for this example of the CHP. The code for the diagnostic process can be easily adjusted for diagnosing other devices, such as electronic circuits. The language is Pascal.

  3. A new method for lumbar herniated inter-vertebral disc diagnosis based on image analysis of transverse sections.

    Science.gov (United States)

    Tsai, Ming Dar; Jou, Shyan Bin; Hsieh, Ming Shium

    2002-01-01

    This paper describes an image analysis method that uses automatic algorithms for the evaluation of herniation classification and geometry in the diagnosis of lumbar herniated inter-vertebral disc (HIVD). The method uses boundary approximation that uses a B-spline curve to approximate circle-like disc boundary and excludes the herniation from other normal parts of the disc boundary and, feature recognition that classifies the herniation, and herniation shape reconstruction that infers the 3D geometry from one or more transverse sections. This method can be used as a qualitative and quantitative tool for the diagnosis of lumbar HIVD using transverse sections.

  4. Methods of rapid diagnosis for the etiology of meningitis in adults

    Science.gov (United States)

    Bahr, Nathan C; Boulware, David R

    2014-01-01

    Infectious meningitis may be due to bacterial, mycobacterial, fungal or viral agents. Diagnosis of meningitis must take into account numerous items of patient history and symptomatology along with regional epidemiology and basic cerebrospinal fluid testing (protein, etc.) to allow the clinician to stratify the likelihood of etiology possibilities and rationally select additional diagnostic tests. Culture is the mainstay for diagnosis in many cases, but technology is evolving to provide more rapid, reliable diagnosis. The cryptococcal antigen lateral flow assay (Immuno-Mycologics) has revolutionized diagnosis of cryptococcosis and automated nucleic acid amplification assays hold promise for improving diagnosis of bacterial and mycobacterial meningitis. This review will focus on a holistic approach to diagnosis of meningitis as well as recent technological advances. PMID:25402579

  5. An Adaptive Multi-Sensor Data Fusion Method Based on Deep Convolutional Neural Networks for Fault Diagnosis of Planetary Gearbox

    Science.gov (United States)

    Jing, Luyang; Wang, Taiyong; Zhao, Ming; Wang, Peng

    2017-01-01

    A fault diagnosis approach based on multi-sensor data fusion is a promising tool to deal with complicated damage detection problems of mechanical systems. Nevertheless, this approach suffers from two challenges, which are (1) the feature extraction from various types of sensory data and (2) the selection of a suitable fusion level. It is usually difficult to choose an optimal feature or fusion level for a specific fault diagnosis task, and extensive domain expertise and human labor are also highly required during these selections. To address these two challenges, we propose an adaptive multi-sensor data fusion method based on deep convolutional neural networks (DCNN) for fault diagnosis. The proposed method can learn features from raw data and optimize a combination of different fusion levels adaptively to satisfy the requirements of any fault diagnosis task. The proposed method is tested through a planetary gearbox test rig. Handcraft features, manual-selected fusion levels, single sensory data, and two traditional intelligent models, back-propagation neural networks (BPNN) and a support vector machine (SVM), are used as comparisons in the experiment. The results demonstrate that the proposed method is able to detect the conditions of the planetary gearbox effectively with the best diagnosis accuracy among all comparative methods in the experiment. PMID:28230767

  6. [Advance in the methods of preimplantation genetic diagnosis for single gene diseases].

    Science.gov (United States)

    Ren, Yixin; Qiao, Jie; Yan, Liying

    2017-06-10

    More than 7000 single gene diseases have been identified and most of them lack effective treatment. As an early form of prenatal diagnosis, preimplantation genetic diagnosis (PGD) is a combination of in vitro fertilization and genetic diagnosis. PGD has been applied in clinics for more than 20 years to avoid the transmission of genetic defects through analysis of embryos at early stages of development. In this paper, a review for the recent advances in PGD for single gene diseases is provided.

  7. Diagnosis of Dementia by Machine learning methods in Epidemiological studies: a pilot exploratory study from south India.

    Science.gov (United States)

    Bhagyashree, Sheshadri Iyengar Raghavan; Nagaraj, Kiran; Prince, Martin; Fall, Caroline H D; Krishna, Murali

    2018-01-01

    There are limited data on the use of artificial intelligence methods for the diagnosis of dementia in epidemiological studies in low- and middle-income country (LMIC) settings. A culture and education fair battery of cognitive tests was developed and validated for population based studies in low- and middle-income countries including India by the 10/66 Dementia Research Group. We explored the machine learning methods based on the 10/66 battery of cognitive tests for the diagnosis of dementia based in a birth cohort study in South India. The data sets for 466 men and women for this study were obtained from the on-going Mysore Studies of Natal effect of Health and Ageing (MYNAH), in south India. The data sets included: demographics, performance on the 10/66 cognitive function tests, the 10/66 diagnosis of mental disorders and population based normative data for the 10/66 battery of cognitive function tests. Diagnosis of dementia from the rule based approach was compared against the 10/66 diagnosis of dementia. We have applied machine learning techniques to identify minimal number of the 10/66 cognitive function tests required for diagnosing dementia and derived an algorithm to improve the accuracy of dementia diagnosis. Of 466 subjects, 27 had 10/66 diagnosis of dementia, 19 of whom were correctly identified as having dementia by Jrip classification with 100% accuracy. This pilot exploratory study indicates that machine learning methods can help identify community dwelling older adults with 10/66 criterion diagnosis of dementia with good accuracy in a LMIC setting such as India. This should reduce the duration of the diagnostic assessment and make the process easier and quicker for clinicians, patients and will be useful for 'case' ascertainment in population based epidemiological studies.

  8. SELF-DIAGNOSIS METHOD FOR CHECKING THE WAYSIDE SYSTEMS FOR WHEEL-RAIL VERTICAL LOAD MEASUREMENT

    Directory of Open Access Journals (Sweden)

    Daniele CORTIS

    2017-12-01

    Full Text Available Nowadays, wayside measurement systems of wheel-rail contact forces have acquired great relevance for the monitoring of rolling stock, especially for freight trains. Thanks to these solutions, infrastructure managers can check and monitor the status of rolling stock and, when necessary, impose corrective actions for the railway companies. On the other hand, the evaluation of contact forces is part of the rolling stock authorisation process [1] and a mainstone for the study of the running stability. The data provided by these measurements could give useful information to correlate the wear of the track with the frequency of applied loads, helping in the development of a better maintenance strategy of railway networks [2]. In this paper, the monitoring of vertical forces is based on the SMCV (Vertical Loads Monitoring System method, where shear strains of the rail web are measured with a simple combination of four electrical strain gauges, placed on both sides of the rail web along each span. The research has identified self-diagnosis methods for the SMCV system to ensure the reliability and the quality of the measurements and to extend the knowledge of the system. The recorded signals have been processed and converted into easily interpretable physical quantities by means of MATLAB® algorithm.

  9. The Leukocyte Culture Method in the Diagnosis of Free-martinism

    Science.gov (United States)

    Kanagawa, H.; Basrur, Parvathi K.

    1968-01-01

    The clinical application and reliability of the leukocyte culture method for the diagnosis of freemartinism were examined and the length of time that blood samples could be held at room temperature and in the refrigerator prior to culturing, was investigated. The chromosome findings by the leukocyte culture method in 14 freemartins and 9 non-freemartin females belonging to heterosexual twins or triplets revealed that XX-XY cell chimerism exists only in the former, whereas the latter were exclusively of normal female complement. The mitotic index in bovine blood after preservation for varying periods was studied on samples from two animals. Blood samples from these two animals stored at 5°C for 6 hours in a refrigerator showed the mitotic index to be 3.8 and 5.3 per cent which gradually decreased in samples stored for longer than 12 hours. After 72 hours, a very rapid decrease in mitotic index occurred in both cases, reaching zero in samples stored for 96 and 108 hours. Samples kept at room temperature followed a similar pattern as under refrigeration but with slightly lower values throughout. ImagesFig. 1.Fig. 2. PMID:4234791

  10. A rare case of trihobezoar of the stomach: imaging methods for diagnosis

    International Nuclear Information System (INIS)

    Yanakiev, A.

    2012-01-01

    Full text: Introduction: Bezoar formations are formed in the stomach of ingested foreign particles. In most cases those foreign particles are organic, such as hair, plant fibers, seeds, fruit and vegetables and more. According to their composition bezoars are divided into trihobezoari (composed of hair), fitobezoari (composed of vegetable particles), mixed and others. The most common bezoars are trihobezoars. They are formed by chewing and swallowing hair, especially in girls or occupational disease in people who work with wool (brushmakers). Aim: The aim of this study is to demonstrate the value of non-conventional imaging methods, ultrasound, CT and MRI in the diagnosis of trihobezoar in the stomach. Material and methods: Patient of 70 years is hospitalized in Gastrointestinal ward with abdominal pain, nausea, vomiting, a feeling of satiation and weight loss. At physical examination a moving epigastric formation was found with the following characteristics: size 4-5 cm, smooth, hard surface. The patient was carried out echographic, CT and MRI examinations. Results: With the echographic examination in the lumen of the stomach, it was found mainly hipoehogenic formation of relatively sharp and smooth lines and multiple hyperechogenic inclusions. CT results - the described formation is visualized as a parenchymal lesion with a homogeneous structure and smooth contours. MRI results - the gastric formation appears as hipointensiv mainly in T1 and T2 sequences respectively in T1 and T2 hipointensive areas. The patient underwent surgery and was ultimately diagnosed with trihobezoar in the stomach

  11. Interventional method in diagnosis and treatment of vascular complication after liver transplantation

    International Nuclear Information System (INIS)

    Huang Yonghui; Yang Jianyong; Chen Wei; Zhuang Wenquan; Yu Shenping; Chen Guihua

    2001-01-01

    Objective: To evaluate the role of interventional method in the diagnosis and treatment of vascular complication after liver transplantation. Methods: Seven patients (3 vena cava stenosis, 1 hepatic artery stenosis, 2 hepatic artery thrombosis, and 1 hepatic artery pseudo-aneurysm) with vascular complication after liver transplantation had been studied retrospectively, including the correlative biochemistry data and angiographic signs. Results: Among the 7 patients, 6 patients had been successfully treated by interventional radiology procedure. The technical success rate was 85.56%. The renal functions of 3 patients with vena cava stenosis who had been treated by angioplasty improved satisfactorily. The survival time after this intervention of these 3 patients ranged from 10 days to 20 months. 1 patient still lived 20 months after the intervention, 2 died of other complications beside caval stenosis within one month after the intervention. The hepatic function of the 4 patients with hepatic artery complications treated by interventional procedures had not been redressed. Conclusion: Angiography played an important role in diagnosing the hepatic vascular complication after liver transplantation. The result of interventional radiology treatment of vena cava stenosis was encouraging

  12. Antisperm antibodies as a factor of male infertility. Relevance, modern methods of diagnosis and treatment

    Directory of Open Access Journals (Sweden)

    O. A. Nikiforov

    2017-08-01

    Full Text Available According to WHO statistics 40 % of childless marriage is due to factors of male infertility. One of them is the presence of antisperm antibodies in the male organism, which may be in blood serum, on the surface of spermatozoids and seminal plasma. Aim. Оn the grounds of specialized literature analysis, to show the relevance of this problem in Reproductive Medicine, to descript Basic methods of Modern treatment and diagnosis of this pathology in the body of infertile males. The most common methods of antisperm antibodies identifying are: MAR-test sample Shuvarskiy–Sims–Hyuner, Kurtsrok–Miller test, the method of latex agglutination, solid-phase immunoenzymatic blood test. Indications for antisperm antibodies determining are: modified indices, deviations in post-coital test, a negative test of sperm and cervical mucus interaction in vitro, unexplained infertility in the married couples, failure or low indices during IVF (in vitro fertilization and of course, the exclusion of other causes of infertility. When antisperm antibodies are detected, the strategy of treatment may be destined to reduction of their titer for further pregnancy. Such types of therapy can be used: contraceptive (long-term use contraception barrier to reduce antisperm antibodies titer in women, plasmapheresis, artificial insemination with pretreated from antisperm antibodies husband's sperm, methods of assisted reproductive technologies. Conclusoins. The formation of antisperm antibodies leads to infertility of immunological genesis (in 20 % of couples with unexplained infertility. To confirm their presence in the male body it is necessary to perform the MAR-test, Shuvarsky test, other tests and, of course, the exclusion of other causes of infertility. Men of reproductive age with an immunological factor of infertility provides for a comprehensive treatment, including elimination of all possible causative and contributing factors of infertility (infection of the male

  13. Comparison of molecular methods for visceral leishmaniasis diagnosis in asymptomatic dogs

    International Nuclear Information System (INIS)

    Carregal, Virginia M.; Leite, Rodrigo S.; Andrade, Antero S.R.; Melo, Maria N.

    2011-01-01

    Visceral Leishmaniasis (VL) is a serious public health problem in Brazil. In the urban area dog is the main source of infection and VL control in Brazil involves the elimination of infected dogs. Serological tests are used for routine surveys, but they present problems of specificity and sensitivity. In addition, serologic test performance depends on infection status and an important limitation in VL control programs is the inability to identify asymptomatic dogs because these tests are insufficiently sensitive. Molecular methods as the kPCR PCR - hybridization are useful in the diagnosis and identification of Leishmania species. The kDNA PCR - hybridization uses radioactive probes to improve the sensibility of the PCR and allow the discrimination between Leishmania species. The aim of this work was compare the sensibility of the method kDNA PCR - Hybridization with different PCR methods, in different clinical samples, for VL diagnosis in asymptomatic animals. Bone marrow, peripheral blood, conjunctival swab and skin biopsies had been analyzed by the methods kDNA PCR - hybridization, kDNA semi nested PCR (kDNA snPCR), Leishmania nested PCR (LnPCR) e Internal Transcribed Spacer 1 nested PCR (ITS-1 nPCR). Thirty positive asymptomatic dogs with positive serologic and parasitologic tests were used. Six not infected dogs had been used as controls. The DNA extraction from swabs was performed by Phenol-Chloroform method. Commercial kits had been used for DNA extraction of peripheral blood, bone marrow and skin biopsies. The kDNA PCR - hybridization detected 5/30 (16.7 %) positive dogs for peripheral blood, 17/30 (57%) for skin, 19/30 (63.3 %) for bone marrow and 21/30 (70%) for conjunctival swab. The kDNA snPCR found 7/30 (23.3%) positive dogs for peripheral blood, 17/30 (57%) for skin, 12/30 (40%) for bone marrow and 24/30 (80%) samples of conjunctival swab. The LnPCR method detected 9/30 (30%) positive dogs for the samples of peripheral blood, 15/30 (50%) for bone

  14. Comparison of molecular methods for visceral leishmaniasis diagnosis in asymptomatic dogs

    Energy Technology Data Exchange (ETDEWEB)

    Carregal, Virginia M.; Leite, Rodrigo S.; Andrade, Antero S.R., E-mail: antero@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil). Lab. de Radiobiologia; Melo, Maria N., E-mail: melo@icb.ufmg.br [Universidade Federal de Minas Gerais (ICB/UFMG), Belo Horizonte, MG (Brazil). Inst. de Ciencias Biologicas. Dept. de Parasitologia

    2011-07-01

    Visceral Leishmaniasis (VL) is a serious public health problem in Brazil. In the urban area dog is the main source of infection and VL control in Brazil involves the elimination of infected dogs. Serological tests are used for routine surveys, but they present problems of specificity and sensitivity. In addition, serologic test performance depends on infection status and an important limitation in VL control programs is the inability to identify asymptomatic dogs because these tests are insufficiently sensitive. Molecular methods as the kPCR PCR - hybridization are useful in the diagnosis and identification of Leishmania species. The kDNA PCR - hybridization uses radioactive probes to improve the sensibility of the PCR and allow the discrimination between Leishmania species. The aim of this work was compare the sensibility of the method kDNA PCR - Hybridization with different PCR methods, in different clinical samples, for VL diagnosis in asymptomatic animals. Bone marrow, peripheral blood, conjunctival swab and skin biopsies had been analyzed by the methods kDNA PCR - hybridization, kDNA semi nested PCR (kDNA snPCR), Leishmania nested PCR (LnPCR) e Internal Transcribed Spacer 1 nested PCR (ITS-1 nPCR). Thirty positive asymptomatic dogs with positive serologic and parasitologic tests were used. Six not infected dogs had been used as controls. The DNA extraction from swabs was performed by Phenol-Chloroform method. Commercial kits had been used for DNA extraction of peripheral blood, bone marrow and skin biopsies. The kDNA PCR - hybridization detected 5/30 (16.7 %) positive dogs for peripheral blood, 17/30 (57%) for skin, 19/30 (63.3 %) for bone marrow and 21/30 (70%) for conjunctival swab. The kDNA snPCR found 7/30 (23.3%) positive dogs for peripheral blood, 17/30 (57%) for skin, 12/30 (40%) for bone marrow and 24/30 (80%) samples of conjunctival swab. The LnPCR method detected 9/30 (30%) positive dogs for the samples of peripheral blood, 15/30 (50%) for bone

  15. Constitutional collisions of criminal law

    Directory of Open Access Journals (Sweden)

    Sergey M. Inshakov

    2016-12-01

    Full Text Available Objective to identify and resolve conflicts between the norms of constitutional and criminal law which regulate the issue of legal liability of senior officials of the state. Methods formallogical systematic comparativelegal. Results the article analyzes the embodiment of the principle of citizensrsquo equality under the law regarding the criminal responsibility of the President of the Russian Federation as one of the segments of the elite right other criminal and legal conflicts are considered associated with the creation of conditions for derogation from the principle of equality. Basing on this analysis the means of overcoming collisions between the norms of constitutional and criminal law are formulated. Scientific novelty in the article for the first time it has been shown that in the Russian criminal law there are exceptions to the principle of citizensrsquo equality under the law relating to the President of the Russian Federation the conflicts are identified between the norms of constitutional and criminal law regulating the issue of legal liability of senior officials of the state ways of overcoming conflicts are suggested. Practical significance the main provisions and conclusions of the article can be used in research and teaching in the consideration of issues of senior state officialsrsquo criminal liability.

  16. Comparison of conventional methods for diagnosis of visceral leishmaniasis in children of the Center-West Region of Brazil

    Directory of Open Access Journals (Sweden)

    Yvone M. Brustoloni

    Full Text Available In Brazil, sophisticated techniques currently employed for diagnosis of visceral leishmaniasis, such as polymerase chain reaction-based assays, are only available in major research centers, whereas conventional methods are still used in many areas where the disease occurs. In the state of Mato Grosso do Sul, in the country's Center-West Region, visceral leishmaniasis has recently emerged in many cities, and duration of the disease, from the onset of symptoms to diagnosis, has been short. Considering that results of diagnostic tests may depend on the phase of the disease, we compared direct examination of bone marrow aspirates (BMAs, BMA culture, and serology by Indirect Immunofluorescence Antibody Test (IFAT for diagnosis in children, according to time of evolution (30 days and to spleen size ( 5 cm at admission. Duration of the illness did not interfere with test positivity: direct smear examination and IFAT were positive in more than 80% of patients, as was culture in around 60%. Results of positive microscopy, however, where predominant in patients with larger spleens. Thanks to the association of traditional techniques, only a few patients had to begin a treatment trial without confirming the diagnosis. Conventional methods for diagnosis of visceral leishmaniasis are still indispensable in our region, and training professionals in basic techniques should be incremented. The highest sensitivity in laboratory diagnosis among the cases investigated was that obtained with a combination of BMA direct examination and IFAT, nearing 100%.

  17. Malignant gliomas: current perspectives in diagnosis, treatment, and early response assessment using advanced quantitative imaging methods

    Directory of Open Access Journals (Sweden)

    Ahmed R

    2014-03-01

    Full Text Available Rafay Ahmed,1 Matthew J Oborski,2 Misun Hwang,1 Frank S Lieberman,3 James M Mountz11Department of Radiology, 2Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; 3Department of Neurology and Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAAbstract: Malignant gliomas consist of glioblastomas, anaplastic astrocytomas, anaplastic oligodendrogliomas and anaplastic oligoastrocytomas, and some less common tumors such as anaplastic ependymomas and anaplastic gangliogliomas. Malignant gliomas have high morbidity and mortality. Even with optimal treatment, median survival is only 12–15 months for glioblastomas and 2–5 years for anaplastic gliomas. However, recent advances in imaging and quantitative analysis of image data have led to earlier diagnosis of tumors and tumor response to therapy, providing oncologists with a greater time window for therapy management. In addition, improved understanding of tumor biology, genetics, and resistance mechanisms has enhanced surgical techniques, chemotherapy methods, and radiotherapy administration. After proper diagnosis and institution of appropriate therapy, there is now a vital need for quantitative methods that can sensitively detect malignant glioma response to therapy at early follow-up times, when changes in management of nonresponders can have its greatest effect. Currently, response is largely evaluated by measuring magnetic resonance contrast and size change, but this approach does not take into account the key biologic steps that precede tumor size reduction. Molecular imaging is ideally suited to measuring early response by quantifying cellular metabolism, proliferation, and apoptosis, activities altered early in treatment. We expect that successful integration of quantitative imaging biomarker assessment into the early phase of clinical trials could provide a novel approach for testing new therapies

  18. Application of blocking diagnosis methods to general circulation models. Part II: model simulations

    Energy Technology Data Exchange (ETDEWEB)

    Barriopedro, D.; Trigo, R.M. [Universidade de Lisboa, CGUL-IDL, Faculdade de Ciencias, Lisbon (Portugal); Garcia-Herrera, R.; Gonzalez-Rouco, J.F. [Universidad Complutense de Madrid, Departamento de Fisica de la Tierra II, Facultad de C.C. Fisicas, Madrid (Spain)

    2010-12-15

    A previously defined automatic method is applied to reanalysis and present-day (1950-1989) forced simulations of the ECHO-G model in order to assess its performance in reproducing atmospheric blocking in the Northern Hemisphere. Unlike previous methodologies, critical parameters and thresholds to estimate blocking occurrence in the model are not calibrated with an observed reference, but objectively derived from the simulated climatology. The choice of model dependent parameters allows for an objective definition of blocking and corrects for some intrinsic model bias, the difference between model and observed thresholds providing a measure of systematic errors in the model. The model captures reasonably the main blocking features (location, amplitude, annual cycle and persistence) found in observations, but reveals a relative southward shift of Eurasian blocks and an overall underestimation of blocking activity, especially over the Euro-Atlantic sector. Blocking underestimation mostly arises from the model inability to generate long persistent blocks with the observed frequency. This error is mainly attributed to a bias in the basic state. The bias pattern consists of excessive zonal winds over the Euro-Atlantic sector and a southward shift at the exit zone of the jet stream extending into in the Eurasian continent, that are more prominent in cold and warm seasons and account for much of Euro-Atlantic and Eurasian blocking errors, respectively. It is shown that other widely used blocking indices or empirical observational thresholds may not give a proper account of the lack of realism in the model as compared with the proposed method. This suggests that in addition to blocking changes that could be ascribed to natural variability processes or climate change signals in the simulated climate, attention should be paid to significant departures in the diagnosis of phenomena that can also arise from an inappropriate adaptation of detection methods to the climate of the

  19. A novel Multiple-Marker Method for the Early Diagnosis of Oral Squamous Cell Carcinoma

    Directory of Open Access Journals (Sweden)

    Jutta Ries

    2009-01-01

    Full Text Available Objective: Melanoma associated antigens-A (MAGE-A expression is highly specific to cancer cells. Thus, they can be the most suitable targets for the diagnosis of malignancy. The aim of this study was to evaluate the sensitivity of multiple MAGE-A expression analysis for the diagnosis of oral squamous cell carcinoma (OSCC.

  20. A method for reducing the sloughing of thick blood films for malaria diagnosis.

    Science.gov (United States)

    Norgan, Andrew P; Arguello, Heather E; Sloan, Lynne M; Fernholz, Emily C; Pritt, Bobbi S

    2013-07-08

    The gold standard for malaria diagnosis is the examination of thick and thin blood films. Thick films contain 10 to 20 times more blood than thin films, correspondingly providing increased sensitivity for malaria screening. A potential complication of thick film preparations is sloughing of the blood droplet from the slide during staining or rinsing, resulting in the loss of sample. In this work, two methods for improving thick film slide adherence ('scratch' (SCM) and 'acetone dip' (ADM) methods) were compared to the 'standard method' (SM) of thick film preparation. Standardized blood droplets from 26 previously examined EDTA whole blood specimens (22 positive and four negative) were concurrently spread on glass slides using the SM, ADM, and SCM. For the SM and ADM prepared slides, the droplet was gently spread to an approximate 22 millimeters in diameter spot on the slide using the edge of a second glass slide. For the SCM, the droplet was spread by carefully grinding (or scratching) it into the slide with the point of a second glass slide. Slides were dried for one hour in a laminar flow hood. For the ADM, slides were dipped once in an acetone filled Coplin jar and allowed to air dry. All slides were then Giemsa-stained and examined in a blinded manner. Adherence was assessed by blinded reviewers. No significant or severe defects were observed for slides prepared with the SCM. In contrast, 8 slides prepared by the ADM and 3 prepared using the SM displayed significant or severe defects. Thick films prepared by the three methods were microscopically indistinguishable and concordant results (positive or negative) were obtained for the three methods. Estimated parasitaemia of the blood samples ranged from 25 to 429,169 parasites/μL of blood. The SCM is an inexpensive, rapid, and simple method that improves the adherence of thick blood films to standard glass slides without altering general slide preparation, microscopic appearance or interpretability. Using the SCM

  1. Method of modelization assistance with bond graphs and application to qualitative diagnosis of physical systems

    International Nuclear Information System (INIS)

    Lucas, B.

    1994-05-01

    After having recalled the usual diagnosis techniques (failure index, decision tree) and those based on an artificial intelligence approach, the author reports a research aimed at exploring the knowledge and model generation technique. He focuses on the design of an aid to model generation tool and aid-to-diagnosis tool. The bond graph technique is shown to be adapted to the aid to model generation, and is then adapted to the aid to diagnosis. The developed tool is applied to three projects: DIADEME (a diagnosis system based on physical model), the improvement of the SEXTANT diagnosis system (an expert system for transient analysis), and the investigation on an Ariane 5 launcher component. Notably, the author uses the Reiter and Greiner algorithm

  2. Echocardiography as a Predicting Method in Diagnosis, Evaluation and Assessment of Children with Subvalvar Aortic Stenosis

    Science.gov (United States)

    Bejiqi, Ramush; Bejiqi, Hana; Retkoceri, Ragip

    2016-01-01

    BACKGROUND: Obstruction to the left ventricular outflow of the heart may be above the aortic valve (5%), at the valve (74%), or in the subvalvar region (23%). These anomalies represent 3 to 6% of all patients with congenital heart defects (CHD), and it occurs more often in males (male-female ratio of 4:1). AIM: The purpose of this study was to determine the sensitivity and specificity of transthoracic echocardiography in diagnosis of discrete subaortic membrane, to determine convenient time for surgical intervention, and for identifying involvement of the aortic valve by subaortic shelf. MATERIAL AND METHODS: A retrospective review of the medical records and echocardiograms of 18 patients [14 male (77%) and 4 female (23%)] with discrete subaortic membrane, aged 11 month to 12 years, with mean age of 5 years and 3 month, diagnosed at the Pediatric Clinic in Prishtina, during the period September, 1999 and December, 2010 were done. RESULTS: Four patients, in neonatal age were operated from critical coarctation of the aorta and, initial signs of congestive heart failure were presented. 2 of them were operated in Belgrade, Serbia and 2 in Lausanne, Switzerland. CONCLUSION: In all presented patients bicuspid aortic valve was noted, but none of them subaortic membrane was registered. PMID:27275334

  3. Is preimplantation genetic diagnosis the ideal embryo selection method in aneuploidy screening?

    Directory of Open Access Journals (Sweden)

    Levent Sahin

    2014-10-01

    Full Text Available To select cytogenetically normal embryos, preimplantation genetic diagnosis (PGD aneuploidy screening (AS is used in numerous centers around the world. Chromosomal abnormalities lead to developmental problems, implantation failure, and early abortion of embryos. The usefulness of PGD in identifying single-gene diseases, human leukocyte antigen typing, X-linked diseases, and specific genetic diseases is well-known. In this review, preimplantation embryo genetics, PGD research studies, and the European Society of Human Reproduction and Embryology PGD Consortium studies and reports are examined. In addition, criteria for embryo selection, technical aspects of PGD-AS, and potential noninvasive embryo selection methods are described. Indications for PGD and possible causes of discordant PGD results between the centers are discussed. The limitations of fluorescence in situ hybridization, and the advantages of the array comparative genomic hybridization are included in this review. Although PGD-AS for patients of advanced maternal age has been shown to improve in vitro fertilization outcomes in some studies, to our knowledge, there is not sufficient evidence to use advanced maternal age as the sole indication for PGD-AS. PGD-AS might be harmful and may not increase the success rates of in vitro fertilization. At the same time PGD, is not recommended for recurrent implantation failure and unexplained recurrent pregnancy loss.

  4. An intelligent fault diagnosis method of rolling bearings based on regularized kernel Marginal Fisher analysis

    International Nuclear Information System (INIS)

    Jiang Li; Shi Tielin; Xuan Jianping

    2012-01-01

    Generally, the vibration signals of fault bearings are non-stationary and highly nonlinear under complicated operating conditions. Thus, it's a big challenge to extract optimal features for improving classification and simultaneously decreasing feature dimension. Kernel Marginal Fisher analysis (KMFA) is a novel supervised manifold learning algorithm for feature extraction and dimensionality reduction. In order to avoid the small sample size problem in KMFA, we propose regularized KMFA (RKMFA). A simple and efficient intelligent fault diagnosis method based on RKMFA is put forward and applied to fault recognition of rolling bearings. So as to directly excavate nonlinear features from the original high-dimensional vibration signals, RKMFA constructs two graphs describing the intra-class compactness and the inter-class separability, by combining traditional manifold learning algorithm with fisher criteria. Therefore, the optimal low-dimensional features are obtained for better classification and finally fed into the simplest K-nearest neighbor (KNN) classifier to recognize different fault categories of bearings. The experimental results demonstrate that the proposed approach improves the fault classification performance and outperforms the other conventional approaches.

  5. [The role of neurovisualization methods in diagnosis and verification of vertigo etiology].

    Science.gov (United States)

    Alekseeva, N S; Krotenkova, M V; Konovalov, R N; Kirichenko, I M; Baev, A A; Petrova, E I

    2006-01-01

    Roentgen computed tomography (RCT) and MR-imaging (MRI) were used in investigation of vertigo etiology and affection of the cochleovestibular analyzer in 130 patients aged 28 to 74 years with recurrent systemic rotatory vertigo or its other symptoms. All the patients have undergone comprehensive otoneurological examination, RCT and MRI which showed that peripheral cochleovestibular syndromes (PCVS) caused by arterial hypertension (AH), atherosclerosis (AS), vascular dystonia (VD) are rarely characterized by focal alterations in the brain. PCVS comparison with blood flow in the vertebral arteries (VA) detected most frequently anomalies and asymmetries of the diameters. MR-angiography plays an important role in verification of pathology of intracranial VA. In central cochleovestibular syndrome (CCVS) with AH, AS, VD, principal pathological changes were registered in the brain trunk and cerebellum by MRI. Vestibulometry and otoneurological method detect not only vascular cochleovestibular peripheral and central syndromes but also to make differential diagnosis. RCT and MRI verify cochleovestibular syndromes in patients with multiple encephalomyelitis, VIII nerve neurinoma and tumors of the posterior cranial fossa.

  6. A ROC-based feature selection method for computer-aided detection and diagnosis

    Science.gov (United States)

    Wang, Songyuan; Zhang, Guopeng; Liao, Qimei; Zhang, Junying; Jiao, Chun; Lu, Hongbing

    2014-03-01

    Image-based computer-aided detection and diagnosis (CAD) has been a very active research topic aiming to assist physicians to detect lesions and distinguish them from benign to malignant. However, the datasets fed into a classifier usually suffer from small number of samples, as well as significantly less samples available in one class (have a disease) than the other, resulting in the classifier's suboptimal performance. How to identifying the most characterizing features of the observed data for lesion detection is critical to improve the sensitivity and minimize false positives of a CAD system. In this study, we propose a novel feature selection method mR-FAST that combines the minimal-redundancymaximal relevance (mRMR) framework with a selection metric FAST (feature assessment by sliding thresholds) based on the area under a ROC curve (AUC) generated on optimal simple linear discriminants. With three feature datasets extracted from CAD systems for colon polyps and bladder cancer, we show that the space of candidate features selected by mR-FAST is more characterizing for lesion detection with higher AUC, enabling to find a compact subset of superior features at low cost.

  7. Fault Diagnosis of Internal Combustion Engine Valve Clearance Using the Impact Commencement Detection Method

    Science.gov (United States)

    Jiang, Zhinong; Wang, Zijia; Zhang, Jinjie

    2017-01-01

    Internal combustion engines (ICEs) are widely used in many important fields. The valve train clearance of an ICE usually exceeds the normal value due to wear or faulty adjustment. This work aims at diagnosing the valve clearance fault based on the vibration signals measured on the engine cylinder heads. The non-stationarity of the ICE operating condition makes it difficult to obtain the nominal baseline, which is always an awkward problem for fault diagnosis. This paper overcomes the problem by inspecting the timing of valve closing impacts, of which the referenced baseline can be obtained by referencing design parameters rather than extraction during healthy conditions. To accurately detect the timing of valve closing impact from vibration signals, we carry out a new method to detect and extract the commencement of the impacts. The results of experiments conducted on a twelve-cylinder ICE test rig show that the approach is capable of extracting the commencement of valve closing impact accurately and using only one feature can give a superior monitoring of valve clearance. With the help of this technique, the valve clearance fault becomes detectable even without the comparison to the baseline, and the changing trend of the clearance could be trackable. PMID:29244722

  8. Fault Diagnosis of Internal Combustion Engine Valve Clearance Using the Impact Commencement Detection Method.

    Science.gov (United States)

    Jiang, Zhinong; Mao, Zhiwei; Wang, Zijia; Zhang, Jinjie

    2017-12-15

    Internal combustion engines (ICEs) are widely used in many important fields. The valve train clearance of an ICE usually exceeds the normal value due to wear or faulty adjustment. This work aims at diagnosing the valve clearance fault based on the vibration signals measured on the engine cylinder heads. The non-stationarity of the ICE operating condition makes it difficult to obtain the nominal baseline, which is always an awkward problem for fault diagnosis. This paper overcomes the problem by inspecting the timing of valve closing impacts, of which the referenced baseline can be obtained by referencing design parameters rather than extraction during healthy conditions. To accurately detect the timing of valve closing impact from vibration signals, we carry out a new method to detect and extract the commencement of the impacts. The results of experiments conducted on a twelve-cylinder ICE test rig show that the approach is capable of extracting the commencement of valve closing impact accurately and using only one feature can give a superior monitoring of valve clearance. With the help of this technique, the valve clearance fault becomes detectable even without the comparison to the baseline, and the changing trend of the clearance could be trackable.

  9. [Joint application of 7 interventional pulmonology methods in early diagnosis of lung cancer].

    Science.gov (United States)

    Jin, Fa-Guang; Li, Wang-Ping; Mu, De-Guang; Chu, Dong-Ling; Fu, En-Qing; Xie, Yong-Hong; Lu, Jing-Li; Sun, Ya-Ni

    2009-06-23

    To evaluate the combination of 7 interventional pulmonology methods in early diagnosis of lung cancer. A total of 467 patients with thoracic and pulmonary lesions (include hilum pulmonis lymphadenectasis, mediastinal lymphadenectasis, pulmonary scobination, lump, lamellar infiltration, small amount of pleural fluid and pleural scobination) had negative results via exfoliative cytology, bacteriology and routine bronchoscopy. All these patients had ultrathin bronchoscopy with biopsy and brushing. For those 155 cases whose foci were located at porta pulmonis, inner zone or median zone, the authors applied ultrathin bronchoscopy with biopsy and brushing guided by X-ray. For those 95 cases whose foci were located at median zone or outer zone and unconnected with chest wall, per cutem lung puncture needle aspiration was employed under the guidance of X-ray. For those 102 cases whose foci were tightly connected with pleural membrane, per cutem lung puncture biopsy was employed under the guidance of type-B ultrasonic. For those 59 cases with suspected central airway foci, auto-fluorescence bronchoscopic biopsy and brushing were employed. For those 67 cases with hilum pulmonis or mediastinal lymphadenectasis, endobronchial ultrasonic transbronchial needle aspiration (EBUS-TBNA) was employed. For those 23 cases with small amount of pleural fluid or pleural scobination, electronic thoracoscopic biopsy and brushing were employed. It was found that 118 cases were diagnosed by ultrathin bronchoscopic biopsy and brushing with a positive rate of 25.3% (118/467), 105 cases by ultrathin bronchoscopy with biopsy and brushing guided by X-ray with a positive rate of 67.7% (105/155), 63 cases by per cutem lung puncture needle aspiration under the guidance of X-ray with a positive rate of 66.3% (63/95), 69 cases by per cutem lung puncture biopsy under the guidance of type-B ultrasound with a positive rate of 67.6% (69/102), 18 cases by auto-fluorescence bronchoscopic biopsy and brushing

  10. Method of fault diagnosis in nozzle cascades for U-235 enrichment

    International Nuclear Information System (INIS)

    Schuette, R.; Steinhaus, H.

    1978-09-01

    In a separation nozzle cascade for enrichment of the light uranium isotope U-235 some 450 stages are connected in series. For optimum separation performance of such a plant the design values of the nozzle inlet pressure, of the UF 6 concentration of the UF 6 -cut and the cut of the light additional gas must be matched in all separation stages. Also the feed stream, the product stream, and the tails stream have to be controlled according to the cascade design values. Since it is not possible to measure the cuts directly, these values are calculated on the basis of the material flow balances of the cascade using the pressure values and the UF 6 concentration measurements in each stage, these data being supplemented by concentration measurements in the light and heavy fractions of selected stages. This approach requires the use of a digital computer for processing some 1500 readings to calculate the 2500 plant parameters defining the plant state. This study describes a method of diagnosing the major faults to be expected in a separation nozzle cascade. It is based on the fact that the fault profiles are characterized sufficiently well by maximum values and values to identify the cause of a fault and localize the point where it occurs by means of simple relations between these six values and of their relative positions. The performance of the method has been tested in experiments in the ten-stage pilot plant. For use in commercial separation nozzle cascades the range of performance and the special mode of implementation can be derived from the characteristics of the plant components (separation nozzles, compressors, control valves). The methodological approach in this fault diagnosis also provides the basis for computer aided control procedures to raise a separation cascade from any steady plant condition to its set point operation. (orig./HP) 891 HP [de

  11. Prostate cancer diagnosis: Efficacy of a simple electromagnetic MRI-TRUS fusion method to target biopsies

    International Nuclear Information System (INIS)

    Jelidi, Amina; Ohana, Mickael; Labani, Aïssam; Alemann, Guillaume; Lang, Herve; Roy, Catherine

    2017-01-01

    Highlights: • A very simple electromagnetic device for fusion with MRI examination during TRUS guided biopsies increases the detection of clinically significant prostate cancer. • This device has advantages: a short time for the fusion registration, no additional cumbersome material and no intense training to be fluent with. • Low or intermediate suspicious area for prostate carcinoma on mpMRI can be due to benign histological abnormalities or high grade prostatic intraepithelial neoplasia. - Abstract: Objective: To assess that transrectal ultrasound guidance (TRUS) targeted biopsies (TB) aimed with an easy to use electronic real-time fusion registration device have a higher rate of prostate cancer (PC) detection than standard biopsies (SB). Material and methods: This prospective study included 130 patients referred for TRUS biopsies after suspicious MRI. They underwent 16-core SB and 2 to 3 cores in each MRI suspicious area, using a fusion software. We noted SB and TB positivity for PC and Gleason score (GS). We used the McNemar test to compare SB and TB, with a statistical significance p < 0.05. Results: Among 130 patients, 68.5% had PC. Additional time due to the fusion registration was 3.3 min. One hundred fifteen patients (88.4%) had pathological findings on the histological analysis (prostate cancer n = 89, others n = 26). TB diagnosed PC in 75 patients with negative SB. Positivity rate for PC was significantly higher for TB than SB (p = 0.03). Among highly suspicious MRI lesions, detection rate of histological abnormalities using SB and TB was 96% with 79.7% of PC. Most PC that TB diagnosed alone were clinically significant (86.3%). Conclusion: TRUS biopsies performed with a simple MRI and US electronic fusion is an unrestrainedly method to increase PC diagnosis.

  12. Application of diagnostic methods and molecular diagnosis of hemoglobin disorders in Khuzestan province of Iran

    Science.gov (United States)

    Fakher, Rahim; Bijan, Kaeikhaei; Taghi, Akbari Mohammad

    2007-01-01

    BACKGROUND: The hemoglobinopathies refer to a diverse group of inherited disorders characterized by a reduced synthesis of one or more globin chains (thalassemias) or the synthesis of structurally abnormal hemoglobin (Hb). The thalassemias often coexist with a variety of structural Hb variants giving rise to complex genotypes and an extremely wide spectrum of clinical and hematological phenotypes. Hematological and biochemical investigations and family studies provide essential clues to the different interactions and are fundamental to DNA diagnostics of the Hb disorders. Although DNA diagnostics have made a major impact on our understanding and detection of the hemoglobinopathies, DNA mutation testing should never be considered a shortcut or the test of first choice in the workup of a hemoglobinopathy. MATERIALS AND METHODS: A careful three-tier approach involving: (1) Full blood count (2) Special hematological tests, followed by (3) DNA mutation analysis, provides the most effective way in which to detect primary gene mutations as well as gene-gene interactions that can influence the overall phenotype. With the exception of a few rare deletions and rearrangements, the molecular lesions causing hemoglobinopathies are all identifiable by PCR-based techniques. Furthermore, each at-risk ethnic group has its own combination of common Hb variants and thalassemia mutations. In Iran, there are many different forms of α and β thalassemia. Increasingly, different Hb variants are being detected and their effects per se or in combination with the thalassemias, provide additional diagnostic challenges. RESULTS: We did step-by-step diagnosis workup in 800 patients with hemoglobinopathies who referred to Research center of Thalassemia and Hemoglobinopathies in Shafa Hospital of Ahwaz Joundishapour University of medical sciences, respectively. We detected 173 patients as iron deficiency anemia (IDA) and 627 individuals as thalassemic patients by use of different indices. We

  13. Magnetic resonance tomography - an additive method complementary to ultrasonographic diagnosis of fetal malformations

    International Nuclear Information System (INIS)

    Bloechle, M.; Bollmann, R.; Zienert, A.; Kalache, K.; Koerner, H.; Tennstedt, C.; Ivanow, S.

    1992-01-01

    A case of prenatal sonographic diagnosis of polycystic renal degeneration is reported in this paper. With oligophydramnion established, the extent of the malformation could not be reliable diagnosed by means of sonography. It was also not possible to determine safely whether both kidneys were affected by malformation or if one possibly intact kidney was superimposed by one with dysplasia. In addition, the urinary bladder could not be sonographically delineated with reliability. Magnetic resonance tomography (MRT) was thus performed as an additional modality to complete the fetal diagnosis. The results thus obtained and the role of MRI in prenatal diagnosis and therapy are discussed. (orig.) [de

  14. Constitution, 5 May 1989.

    Science.gov (United States)

    1989-01-01

    This document contains provisions of Cambodia's Constitution of May 5, 1989. Article 7 gives men and women equal rights in marriage and the family, calls for monogamous marriages, and affords social protection to mothers and children. Article 8 guides parent-child relationships. The 14th article defines state property, and the 15th gives citizens full rights to own, use, and inherit land. The use of agricultural and forested land can only be changed with permission. Article 22 assigns educational responsibilities to the state, including free elementary education and a gradual expansion of higher education. Adult literacy classes are also promoted. Article 26 guarantees free medical consultations, and article 27 gives women a 90-day paid maternity leave. Breast-feeding women are also given special privileges. Article 33 guarantees the right to pay equity and to social security benefits. Article 36 grants the freedom to travel, the inviolability of homes, and privacy in correspondence of all types.

  15. Constitution, 5 October 1988.

    Science.gov (United States)

    1989-01-01

    This document contains major provisions of the constitution adopted by Brazil on 5 October 1988. This constitution seeks to promote the welfare of all citizens without discrimination. The equality of all citizens is guaranteed, and the equal rights of women are specifically mentioned. Property rights are also guaranteed and defined. Female inmates are granted the right to remain with their children while breast feeding. Workers are guaranteed a minimum wage, a family allowance for dependents, maternity/paternity leave, specific incentives to protect the labor market for women, retirement benefits, free day care for preschool-age children, pay equity, and equal rights between tenured and sporadically employed workers. Agrarian reform provisions are given, including the authority to expropriate land. Social and economic policies to promote health are called for, and public health services are to be decentralized, to be integrated, and to foster community participation. Pension plan and social assistance provisions are outlined as are duties of the state in regard to education. The amount of money to be dedicated to education is set out, and a national educational plan is called for to achieve such goals as the eradication of illiteracy, the universalization of school attendance, the improvement of instruction, and the provision of vocational training. Specific measures are set out to protect and preserve the environment. Family policy deals with issues of marriage, the definition of a family, divorce, the right to family planning services, and the deterrence of domestic violence. Social protection provisions cover mothers and children, handicapped persons, and protection of minors. Finally, the customs and rights of Indians are protected, with special provisions given to protect land tenure and to protect the rights of Indians in water resource development and prospecting and mining activities.

  16. COMPARATIVE EVALUATION OF THE EFFECTIVENESS OF FIVE METHODS FOR EARLY DIAGNOSIS OF OCCLUSAL CARIES LESIONS – in vitro study.

    Directory of Open Access Journals (Sweden)

    Mirela Marinova-Takorova

    2014-07-01

    Full Text Available Purpose: The aim of the presented in vitro study was to evaluate the effectiveness of the device DIAGNOcam and the laser fluorescence device DIAGNOdent for early diagnosis of occlusal caries and to compare it with three traditional methods – visual and tactile, dye and radiographic examination. Material and methods: The sample consisted of 60 extracted human teeth. Three clinicians diagnosed independently the presence or absence of early occlusal surface caries with the visible tactile method,DIAGNOcam andDIAGNOdent. Then X-rays were taken and the dentists viewed them separately, without magnification.Fuchsine was applied for 30 sec. and then washed under running water for 20 min. Places where dye was present were registered. Statistical analysis was performed with SPSS package of Windows. Results: The results showed high level of correspondence between the authors for all the diagnostic methods. Concerning different methods applied for caries diagnosis there was a correlation between the methods, but it was diverging for the different methods. No correlation between radiographic exam and data obtained with DIAGNOdent and dye staining was observed. Conclusions: Based on the obtained results we may conclude that the least sensitive method for fissure caries diagnosis was the dye staining, followed by the radiographic exam. The results, obtained by DIAGNOdent and DIAGNOcam were very close, but DIAGNOcams’ data was better correlating with the clinical results.DIAGNOcam procedure can be judged as equivalent in the detection of occlusal dentine lesions when compared to clinical results.

  17. Molecular Diagnosis of Brettanomyces bruxellensis’ Sulfur Dioxide Sensitivity Through Genotype Specific Method

    Directory of Open Access Journals (Sweden)

    Marta Avramova

    2018-06-01

    Full Text Available The yeast species Brettanomyces bruxellensis is associated with important economic losses due to red wine spoilage. The most common method to prevent and/or control B. bruxellensis spoilage in winemaking is the addition of sulfur dioxide into must and wine. However, recently, it was reported that some B. bruxellensis strains could be tolerant to commonly used doses of SO2. In this work, B. bruxellensis response to SO2 was assessed in order to explore the relationship between SO2 tolerance and genotype. We selected 145 isolates representative of the genetic diversity of the species, and from different fermentation niches (roughly 70% from grape wine fermentation environment, and 30% from beer, ethanol, tequila, kombucha, etc.. These isolates were grown in media harboring increasing sulfite concentrations, from 0 to 0.6 mg.L-1 of molecular SO2. Three behaviors were defined: sensitive strains showed longer lag phase and slower growth rate and/or lower maximum population size in presence of increasing concentrations of SO2. Tolerant strains displayed increased lag phase, but maximal growth rate and maximal population size remained unchanged. Finally, resistant strains showed no growth variation whatever the SO2 concentrations. 36% (52/145 of B. bruxellensis isolates were resistant or tolerant to sulfite, and up to 43% (46/107 when considering only wine isolates. Moreover, most of the resistant/tolerant strains belonged to two specific genetic groups, allowing the use of microsatellite genotyping to predict the risk of sulfur dioxide resistance/tolerance with high reliability (>90%. Such molecular diagnosis could help the winemakers to adjust antimicrobial techniques and efficient spoilage prevention with minimal intervention.

  18. A new method of CT scanning for the diagnosis of mandibular fractures

    International Nuclear Information System (INIS)

    Tsukagoshi, Taku; Satoh, Kaneshige; Onizuka, Takuya

    1990-01-01

    The condylar neck of the mandible is one of the most common fracture sites in the facial skeleton. Such a fracture is routinely diagnosed by A-P, lateral oblique, and Towne projection roentgenography or orthopantomography. Despite the combination of these films, fracture of the neck of the mandible is still difficult to diagnose definitely. Therefore, a new CT scanning method was developed for diagnosing fractures of the neck of the condylar mandible. The CT axis is projected along the length of the mandible, extending from the condyle to the symphysis. This projection visualizes both the condyle and the mandibular symphysis in the same plane. The patient is placed in a supine position with the head fully extended. The base line, a line extending from the midpoint of the glenoid fossa to the menton, is determined with a lateral facial cephalogram. CT scanning with a 5 mm window is performed in parallel with and 2 cm anterior to and 2 cm posterior to the base line. When CT scanning was performed in a healthy volunteer, the condition of the condyle and the condylar neck of the mandible was clearly shown, and the view extended from the condyle to the symphysis. For automobile accident patients in whom fracture of the neck of the mandible was associated with fracture of the symphysis, two fractures were found in the same plane. A newly developed CT scanning technique is useful in the diagnosis of fractures of the condylar neck of the mandible and in the identification of fractures at other mandibular sites. It also allows scanning of patients in a supine position, which may aid in managing patients with multiple traumas. (N.K.)

  19. Do Parents Recognize Autistic Deviant Behavior Long before Diagnosis? Taking into Account Interaction Using Computational Methods

    Science.gov (United States)

    Saint-Georges, Catherine; Mahdhaoui, Ammar; Chetouani, Mohamed; Cassel, Raquel S.; Laznik, Marie-Christine; Apicella, Fabio; Muratori, Pietro; Maestro, Sandra; Muratori, Filippo; Cohen, David

    2011-01-01

    Background To assess whether taking into account interaction synchrony would help to better differentiate autism (AD) from intellectual disability (ID) and typical development (TD) in family home movies of infants aged less than 18 months, we used computational methods. Methodology and Principal Findings First, we analyzed interactive sequences extracted from home movies of children with AD (N = 15), ID (N = 12), or TD (N = 15) through the Infant and Caregiver Behavior Scale (ICBS). Second, discrete behaviors between baby (BB) and Care Giver (CG) co-occurring in less than 3 seconds were selected as single interactive patterns (or dyadic events) for analysis of the two directions of interaction (CG→BB and BB→CG) by group and semester. To do so, we used a Markov assumption, a Generalized Linear Mixed Model, and non negative matrix factorization. Compared to TD children, BBs with AD exhibit a growing deviant development of interactive patterns whereas those with ID rather show an initial delay of development. Parents of AD and ID do not differ very much from parents of TD when responding to their child. However, when initiating interaction, parents use more touching and regulation up behaviors as early as the first semester. Conclusion When studying interactive patterns, deviant autistic behaviors appear before 18 months. Parents seem to feel the lack of interactive initiative and responsiveness of their babies and try to increasingly supply soliciting behaviors. Thus we stress that credence should be given to parents' intuition as they recognize, long before diagnosis, the pathological process through the interactive pattern with their child. PMID:21818320

  20. A Diagnosis Method for Rotation Machinery Faults Based on Dimensionless Indexes Combined with K-Nearest Neighbor Algorithm

    Directory of Open Access Journals (Sweden)

    Jianbin Xiong

    2015-01-01

    Full Text Available It is difficult to well distinguish the dimensionless indexes between normal petrochemical rotating machinery equipment and those with complex faults. When the conflict of evidence is too big, it will result in uncertainty of diagnosis. This paper presents a diagnosis method for rotation machinery fault based on dimensionless indexes combined with K-nearest neighbor (KNN algorithm. This method uses a KNN algorithm and an evidence fusion theoretical formula to process fuzzy data, incomplete data, and accurate data. This method can transfer the signals from the petrochemical rotating machinery sensors to the reliability manners using dimensionless indexes and KNN algorithm. The input information is further integrated by an evidence synthesis formula to get the final data. The type of fault will be decided based on these data. The experimental results show that the proposed method can integrate data to provide a more reliable and reasonable result, thereby reducing the decision risk.

  1. A Novel Method for Inverter Faults Detection and Diagnosis in PMSM Drives of HEVs based on Discrete Wavelet Transform

    Directory of Open Access Journals (Sweden)

    AKTAS, M.

    2012-11-01

    Full Text Available The paper proposes a novel method, based on wavelet decomposition, for detection and diagnosis of faults (switch short-circuits and switch open-circuits in the driving systems with Field Oriented Controlled Permanent Magnet Synchro?nous Motors (PMSM of Hybrid Electric Vehicles. The fault behaviour of the analyzed system was simulated by Matlab/SIMULINK R2010a. The stator currents during transients were analysed up to the sixth level detail wavelet decomposition by Symlet2 wavelet. The results prove that the proposed fault diagnosis system have very good capabilities.

  2. ECHR and national constitutional courts

    Directory of Open Access Journals (Sweden)

    Nastić Maja

    2015-01-01

    Full Text Available Comprising fundamental rights and freedoms and establishing the effective control system, the European Convention on Human Rights (ECHR encroaches upon the area that is traditional reserved for constitutional law. Although built on the doctrine reserved for international treaty law, the Convention goes beyond the traditional boundaries that exist between international and constitutional law. It has gradually infiltrated into the national legal systems. Constitutional courts have had the crucial role in this process. This paper will focus on the applicability of the ECHR in proceedings before national constitutional courts. Having in mind the jurisdiction of the national constitutional court, the ECHR may be applied in two ways: first, in the process of constitutional review by national constitutional courts and, second, in the process of deciding on constitutional complaints.

  3. VALUATION IN THE CONSTITUTIONAL ERA

    African Journals Online (AJOL)

    Brimer

    16 ..... stem from the pre-constitutional era, and the constitutional framework and its legitimate reform efforts. A decision on what is just ...... Carroll L Alice's Adventures in Wonderland (Digital Scanning Scituate MA. 2007). Dagan 1999 Va L Rev.

  4. Research on method of nuclear power plant operation fault diagnosis based on a combined artificial neural network

    International Nuclear Information System (INIS)

    Liu Feng; Yu Ren; Li Fengyu; Zhang Meng

    2007-01-01

    To solve the online real-time diagnosis problem of the nuclear power plant in operating condition, a method based on a combined artificial neural network is put forward in the paper. Its main principle is: using the BP neural network for the fast group diagnosis, and then using the RBF neural network for distinguishing and verifying the diagnostic result. The accuracy of the method is verified using the simulation values of the key parameters in normal status and malfunction status of a nuclear power plant. The results show that the method combining the advantages of the two neural networks can not only diagnose the learned faults in similar power level of the nuclear power plant quickly and accurately, but also can identify the faults in different power status, as well as the unlearned faults. The outputs of the diagnosis system are in form of the reliability of the faults, and are changing with the lasting of the operation time of the plant. This makes the diagnosis results be more acceptable to operators. (authors)

  5. Legal theology in imposed constitutionalism

    DEFF Research Database (Denmark)

    Abat Ninet, Antoni

    2018-01-01

    The focus of this paper is the question of legitimacy, and how can we consider legitimate an imposed constitution and the subsequent constitutional principles, practices and values that go hand-in-hand with the legal and political acculturation. Constitutional texts around the world are good...

  6. The diffusion of constitutional rights

    NARCIS (Netherlands)

    Goderis, B.V.G.; Versteeg, M.

    Constitutions are commonly regarded as uniquely national products, shaped by domestic ideals and politics. This paper develops and empirically investigates a novel hypothesis, which is that constitutions are also shaped by transnational influence, or “diffusion.” Constitutional rights can diffuse

  7. Ontoteleological Constitution of Entrepreneurship

    Directory of Open Access Journals (Sweden)

    Diego Luiz Teixeira Boava

    2017-06-01

    Full Text Available Entrepreneurship is a pluri-disciplinary phenomenon, object of research in several areas of knowledge. However, studies on this theme present approaches that start to consider entrepreneurship as a field of private knowledge in the phase of epistemological construction. In this context, the aim of this investigation is to contribute to the discussions on the theme, through studies on the ontoteleological constitution of entrepreneurship, in propaedeutic character, deflagrating new approaches. Thus, there is a presentation concerning the study of entrepreneurship, which may emphasize its ontical and ontological aspects. In addition, the reason why it is complex to define entrepreneurship is investigated. Subjects regarding the philosophy of entrepreneurship are introduced, seeking to present the bases for an ontoteleological approach to the phenomenon. Such an approach assumes that the finality of the entrepreneurial act relates to the main principles and transformations required into the organization. Finally, it is concluded that man is an entrepreneurial being, the meta-entrepreneur, and his entrepreneurial actions are not determined by external factors, but rather by the condition of his potentiality.

  8. Method research of fault diagnosis based on rough set for nuclear power plant

    International Nuclear Information System (INIS)

    Chen Zhihui; Xia Hong

    2005-01-01

    Nuclear power equipment fault feature is complicated and uncertain. Rough set theory can express and deal with vagueness and uncertainty, so that it can be introduced nuclear power fault diagnosis to analyze and process historical data to find rule of fault feature. Rough set theory treatment step: Data preprocessing, attribute reduction, attribute value reduction, rule generation. According to discernibility matrix definition and nature, we can utilize discernibility matrix in reduction algorithm that make attribute and attribute value reduction, so that it can minish algorithmic complication and simplify programming. This algorithm is applied to the nuclear power fault diagnosis to generate rules of diagnosis. Using these rules, we have diagnosed five kinds of model faults correctly. (authors)

  9. A quality control method by ultrasonic vibration energy and diagnosis system at trimming process

    International Nuclear Information System (INIS)

    Suh, Chang Min; Song, Gil Ho; Pyoun, Young Shik

    2007-01-01

    In this paper, the characteristics in mechanical properties of ultrasonic cold forging treatment (UCFT) used for the trimming knife and the effects of ultrasonic vibration energy (UVE) into the trimming process on the state of the strip cutting face were studied. And a diagnosis system to quality control for trimming knife and strip cutting face was developed and installed in plant. By the plant application of UCFT, service life of knife was more increased over 100% than that of conventional knife and using the developed diagnosis system, the knife breakage and saw ear have been perfectly detected and quality control of trimming face is effectively obtained

  10. Discussion on “A Fuzzy Method for Medical Diagnosis of Headache”

    Science.gov (United States)

    Hung, Kuo-Chen; Wou, Yu-Wen; Julian, Peterson

    This paper is in response to the report of Ahn, Mun, Kim, Oh, and Han published in IEICE Trans. INF. & SYST., Vol.E91-D, No.4, 2008, 1215-1217. They tried to extend their previous paper that published on IEICE Trans. INF. & SYST., Vol.E86-D, No.12, 2003, 2790-2793. However, we will point out that their extension is based on the detailed data of knowing the frequency of three types. Their new occurrence information based on intuitionistic fuzzy set for medical diagnosis of headache becomes redundant. We advise researchers to directly use the detailed data to decide the diagnosis of headache.

  11. Urgensi Pengaturan Perkara Constitutional Complaint Dalam Kewenangan Mahkamah Konstitusi

    Directory of Open Access Journals (Sweden)

    Rahmat Muhajir Nugroho

    2016-02-01

    Full Text Available This study aimed to evaluate the mechanism for settling disputes in the Constitutional Court containing elements of constitutional complaint. In particular, this study focused on two things: first assessing the urgency/ importance of the idea of setting constitutional complaint in the Constitutional Court's authority. Secondly, to formulate recommendations on setting constitutional complaint in the Constitutional Court's authority. The method used in this research is descriptive qualitative. This type of research is a doctrinal law. This research studied the concept and implementation of the judicial settlement of cases that contain elements of constitutional complaint (complaint constitution by the Constitutional Court. The conclusion of this study is an important constitutional complaint mechanism is contained within the competence of the Constitutional Court to solve problems of injustice experienced by citizens as a result of public policies undertaken by the government in a broad sense, namely the executive, legislature and judiciary. Setting constitutional complaint within the competence of the Constitutional Court does not have to be explicitly stipulated in the constitution, but enough in the explanation of the Constitutional Court Act. That is not to add direct authority of the Court, but expand the meaning of the authority of the Court in testing the law.

  12. Wind Turbine Diagnosis under Variable Speed Conditions Using a Single Sensor Based on the Synchrosqueezing Transform Method.

    Science.gov (United States)

    Guo, Yanjie; Chen, Xuefeng; Wang, Shibin; Sun, Ruobin; Zhao, Zhibin

    2017-05-18

    The gearbox is one of the key components in wind turbines. Gearbox fault signals are usually nonstationary and highly contaminated with noise. The presence of amplitude-modulated and frequency-modulated (AM-FM) characteristics compound the difficulty of precise fault diagnosis of wind turbines, therefore, it is crucial to develop an effective fault diagnosis method for such equipment. This paper presents an improved diagnosis method for wind turbines via the combination of synchrosqueezing transform and local mean decomposition. Compared to the conventional time-frequency analysis techniques, the improved method which is performed in non-real-time can effectively reduce the noise pollution of the signals and preserve the signal characteristics, and hence is suitable for the analysis of nonstationary signals with high noise. This method is further validated by simulated signals and practical vibration data measured from a 1.5 MW wind turbine. The results confirm that the proposed method can simultaneously control the noise and increase the accuracy of time-frequency representation.

  13. Lung scintigraphy in the diagnosis of pulmonary embolism: current methods and interpretation criteria in clinical practice

    International Nuclear Information System (INIS)

    Skarlovnik, Ajda; Hrastnik, Damjana; Fettich, Jure; Grmek, Marko

    2014-01-01

    In current clinical practice lung scintigraphy is mainly used to exclude pulmonary embolism (PE). Modified diagnostic criteria for planar lung scintigraphy are considered, as newer scitigraphic methods, especially single photon emission computed tomography (SPECT) are becoming more popular. Data of 98 outpatients who underwent planar ventilation/perfusion (V/Q) scintigraphy and 49 outpatients who underwent V/Q SPECT from the emergency department (ED) were retrospectively collected. Planar V/Q images were interpreted according to 0.5 segment mismatch criteria and revised PIOPED II criteria and perfusion scans according to PISA-PED criteria. V/Q SPECT images were interpreted according to the criteria suggested in EANM guidelines. Final diagnosis of PE was based on the clinical decision of an attending physician and evaluation of a 12 months follow-up period. Using 0.5 segment mismatch criteria and revised PIOPED II, planar V/Q scans were diagnostic in 93% and 84% of cases, respectively. Among the diagnostic planar scans readings specificity for 0.5 segment mismatch criteria was 98%, and 99% for revised PIOPED II criteria. V/Q SPECT showed a sensitivity of 100% and a specificity of 98%, without any non-diagnostic cases. In patients with low pretest probability for PE, planar V/Q scans assessed by 0.5 segment mismatch criteria were diagnostic in 92%, and in 85% using revised PIOPED II criteria, while perfusion scintigraphy without ventilation scans was diagnostic in 80%. Lung scintigraphy yielded diagnostically definitive results and is reliable in ruling out PE in patients from ED. V/Q SPECT has excellent specificity and sensitivity without any non-diagnostic results. Percentage of non-diagnostic results in planar lung scintigraphy is considerably smaller when 0.5 segment mismatch criteria instead of revised PIOPED II criteria are used. Diagnostic value of perfusion scintigraphy according to PISA-PED criteria is inferior to combined V/Q scintigraphy; the difference is

  14. Methods of validating the Advanced Diagnosis and Warning system for aircraft ICing Environments (ADWICE)

    Science.gov (United States)

    Rosczyk, S.; Hauf, T.; Leifeld, C.

    2003-04-01

    In-flight icing is one of the most hazardous problems in aviation. It was determined as contributing factor in more than 800 incidents worldwide. And though the meteorological factors of airframe icing become more and more transparent, they have to be integrated into the Federal Aviation Administration's (FAA) certification rules first. Therefore best way to enhance aviational safety is to know the areas of dangerous icing conditions in order to prevent flying in them. For this reason the German Weather Service (DWD), the Institute for Atmospheric Physics at the German Aerospace Centre (DLR) and the Institute of Meteorology and Climatology (ImuK) of the University of Hanover started developingADWICE - theAdvanced Diagnosis and Warning system for aircraft ICing Environments - in 1998. This algorithm is based on the DWDLocal Model (LM) forecast of temperature and humidity, in fusion with radar and synop and, coming soon, satellite data. It gives an every-hour nowcast of icing severity and type - divided into four categories: freezing rain, convective, stratiform and general - for the middle European area. A first validation of ADWICE took place in 1999 with observational data from an in-flight icing campaign during EURICE in 1997. The momentary validation deals with a broader database. As first step the output from ADWICE is compared to observations from pilots (PIREPs) to get a statistic of the probability of detecting icing and either no-icing conditions within the last icing-seasons. There were good results of this method with the AmericanIntegrated Icing Diagnostic Algorithm (IIDA). A problem though is the small number of PIREPs from Europe in comparison to the US. So a temporary campaign of pilots (including Lufthansa and Aerolloyd) collecting cloud and icing information every few miles is intended to solve this unpleasant situation. Another source of data are the measurements of theFalcon - a DLR research aircraft carrying an icing sensor. In addition to that

  15. Constitution, 1989. [Selected provisions].

    Science.gov (United States)

    1989-01-01

    Chapter XII of the Hungarian Constitution, 1989, details the Fundamental Rights and Duties of Citizens. Everyone lawfully within the territory of Hungary has the right to liberty of movement and the freedom to choose his or her residence, except when restricted by law, including the right to leave his or her residence or county. The Republic of Hungary grants asylum to foreign citizens who were persecuted for racial, religious ethnic, linguistic, or political reasons. Men and women shall equally enjoy all civil, political, economic, social and political rights. Mothers are entitled to special care and protection before and after childbirth; women and juveniles are protected at work by special regulations. Every child has the right to special care an assistance from his or her family, the State, and society, for appropriate physical, spiritual, and moral development. Parents shall decide the kind of education their children receive. Hungary grants equal rights to all person within its territories, without regard to race, color, sex, language, religion, political, or other opinion, national, and social origin, property, birth and other status. Prejudicial discrimination shall be severely punished. Everyone has the right to work, to the free choice of employment and profession and to equal pay for equal work. Citizens have the right to social security, including social services necessary in old age, sickness, disability, widowhood, orphanhood an unemployment through no fault of their own. Hungary guarantees the right to culture for its citizens and realized this right by free and compulsory elementary education, by secondary and higher education which is accessible to all on the basis of capacity, and by the financial support of those receiving an education.

  16. Application of an improved enzyme-linked immunosorbent assay method for serological diagnosis of canine leishmaniasis

    NARCIS (Netherlands)

    Santarém, Nuno; Silvestre, Ricardo; Cardoso, Luís; Schallig, Henk; Reed, Steven G.; Cordeiro-da-Silva, Anabela

    2010-01-01

    Accurate diagnosis of canine leishmaniasis (CanL) is essential toward a more efficient control of this zoonosis, but it remains problematic due to the high incidence of asymptomatic infections. In this study, we present data on the development of enzyme-linked immunosorbent assay (ELISA)-based

  17. Diagnosis of Periodontal Diseases: Building a Bridge from Today's Methods to Tomorrow's Technology.

    Science.gov (United States)

    Jeffcoat, Marjorie K.

    1994-01-01

    A discussion of advancements in diagnosis of periodontal diseases looks first at the screening process, reviews specific periodontal diseases and their clinical signs and symptoms, and explains both traditional and newly developed diagnostic tests. A framework for understanding the tests' clinical usefulness is also presented. (MSE)

  18. Constitutional judges (guarantee of the Constitution and responsibility

    Directory of Open Access Journals (Sweden)

    Francisco Javier Ansuátegui Roig

    2012-06-01

    Full Text Available My aim in this paper is to propose a reflection on the position and the importance that the constitutional judge has in the legal systems of contemporary constitutionalism. The figure of the judge responsible of protecting the Constitution is a key institution, without which we cannot understand the laws of constitutional democracies, their current lines of development, and the guarantee of rights and freedoms that constitute the normative core of these systems. Moreover, the reflection on the exercise of the powers of the judge, its scope and its justification is an important part of contemporary legal discussion, still relevant, albeit not exclusively - in the field of legal philosophy. The object of attention of my reflection is the judge who has the power of judicial review, in a scheme of defense of the Constitution, regardless the specific ways of this defense.

  19. [Etiologic spectrum of solitary constitutional syndrome].

    Science.gov (United States)

    Hernández Hernández, J L; Matorras Galán, P; Riancho Moral, J A; González-Macías, J

    2002-07-01

    To know the spectrum of diseases responsible for the solitary constitutional syndrome in our setting. This syndrome was defined as a clinical picture characterized by the presence of asthenia, anorexia, and weight loss of at least 5% of body weight in the last six months, not associated with any other symptom or sign suggesting the diagnosis of an organ or system disease. All patients diagnosed of the solitary constitutional syndrome (328) in a tertiary-care level teaching hospital between January 1991 and December 1996. Fifty-two (170) percent of patients with solitary constitutional syndrome were males and 48% (158) females. The mean age was 65.4%, ranging from 15 to 97 years. The average of the monthly estimated weight loss was 3 to 4 kilograms. A total of 115 (35%) malignant neoplasms and 5 (1.5%) benign tumors were diagnosed. The most common malignant tumors corresponded to the digestive tract (51.3% of the total malignant tumors). The second cause in frequency of the solitary constitutional syndrome corresponded to psychiatric diseases, with a total of 80 patients (24.3%). A total of 116 non-neoplastic organic diseases were detected, with digestive tract diseases --mainly peptic disease-- being the most common cause in this group. After follow-up, only in twenty cases were we unable to detect the underlying disease responsible for the syndrome. In nine of these, the solitary constitutional syndrome was self-limited. Forty-four percent of patients had at least another concomitant disease and in 24% of patients more than one associated condition was found. The most common diseases responsible for the solitary constitutional syndrome were, by decreasing frequency, malignant tumors, psychiatric disorders, and non-malignant organic diseases located in the digestive tract. A better knowledge of the etiological spectrum of this syndrome might be useful for a more efficient management of these patients.

  20. Essential Medicines in National Constitutions

    Science.gov (United States)

    Toebes, Brigit; Hogerzeil, Hans

    2016-01-01

    Abstract A constitutional guarantee of access to essential medicines has been identified as an important indicator of government commitment to the progressive realization of the right to the highest attainable standard of health. The objective of this study was to evaluate provisions on access to essential medicines in national constitutions, to identify comprehensive examples of constitutional text on medicines that can be used as a model for other countries, and to evaluate the evolution of constitutional medicines-related rights since 2008. Relevant articles were selected from an inventory of constitutional texts from WHO member states. References to states’ legal obligations under international human rights law were evaluated. Twenty-two constitutions worldwide now oblige governments to protect and/or to fulfill accessibility of, availability of, and/or quality of medicines. Since 2008, state responsibilities to fulfill access to essential medicines have expanded in five constitutions, been maintained in four constitutions, and have regressed in one constitution. Government commitments to essential medicines are an important foundation of health system equity and are included increasingly in state constitutions. PMID:27781006

  1. A deep convolutional neural network with new training methods for bearing fault diagnosis under noisy environment and different working load

    Science.gov (United States)

    Zhang, Wei; Li, Chuanhao; Peng, Gaoliang; Chen, Yuanhang; Zhang, Zhujun

    2018-02-01

    In recent years, intelligent fault diagnosis algorithms using machine learning technique have achieved much success. However, due to the fact that in real world industrial applications, the working load is changing all the time and noise from the working environment is inevitable, degradation of the performance of intelligent fault diagnosis methods is very serious. In this paper, a new model based on deep learning is proposed to address the problem. Our contributions of include: First, we proposed an end-to-end method that takes raw temporal signals as inputs and thus doesn't need any time consuming denoising preprocessing. The model can achieve pretty high accuracy under noisy environment. Second, the model does not rely on any domain adaptation algorithm or require information of the target domain. It can achieve high accuracy when working load is changed. To understand the proposed model, we will visualize the learned features, and try to analyze the reasons behind the high performance of the model.

  2. [Effect of elastic strain rate ratio method and virtual touch tissue quantification on the diagnosis of breast masses].

    Science.gov (United States)

    Gong, LiJie; He, Yan; Tian, Peng; Yan, Yan

    2016-07-01

    To determine the effect of elastic strain rate ratio method and virtual touch tissue quantification (VTQ) on the diagnosis of breast masses.
 Sixty female patients with breast cancer, who received surgical treatment in Daqing Oilfield General Hospital, were enrolled. All patients signed the informed consent paperwork and they were treated by routine ultrasound examination, compression elastography (CE) examination, and VTQ examination in turn. Strain ratio (SR) was checked by CE and shear wave velocity (SWV) value was measured by VTQ. The diagnostic values of different methods were evaluated by receiver operating characteristic (ROC) curves in the diagnosis of benign and malignant breast tumors.
 The maximum diameter and SWV value of the benign tumors were lower than those of the malignant tumors, and the SR ratio of benign masses was higher than that of malignant tumors (Pbreast mass than that used alone.

  3. James Madison's "Public" As Interpreter of the Constitution.

    Science.gov (United States)

    Dewey, Donald O.

    James Madison's thoughts on various interpretations of the Constitution maintain that public opinion is the ultimate method of legitimizing the document. The Constitution must prevail against mere public opinion, but public opinion may be used to establish the meaning of the Constitution when conflicting interpretations exist. The public good and…

  4. Proteomic Mass Spectrometry Imaging for Skin Cancer Diagnosis.

    Science.gov (United States)

    Lazova, Rossitza; Seeley, Erin H

    2017-10-01

    Mass spectrometry imaging can be successfully used for skin cancer diagnosis, particularly for the diagnosis of challenging melanocytic lesions. This method analyzes proteins within benign and malignant melanocytic tumor cells and, based on their differences, which constitute a unique molecular signature of 5 to 20 proteins, can render a diagnosis of benign nevus versus malignant melanoma. Mass spectrometry imaging may assist in the differentiation between metastases and nevi as well as between proliferative nodules in nevi and melanoma arising in a nevus. In the difficult area of atypical Spitzoid neoplasms, mass spectrometry diagnosis can predict clinical outcome better than histopathology. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Echocardiography as a Predicting Method in Diagnosis, Evaluation and Assessment of Children with Subvalvar Aortic Stenosis

    OpenAIRE

    Bejiqi, Ramush; Bejiqi, Hana; Retkoceri, Ragip

    2016-01-01

    BACKGROUND: Obstruction to the left ventricular outflow of the heart may be above the aortic valve (5%), at the valve (74%), or in the subvalvar region (23%). These anomalies represent 3 to 6% of all patients with congenital heart defects (CHD), and it occurs more often in males (male-female ratio of 4:1). AIM: The purpose of this study was to determine the sensitivity and specificity of transthoracic echocardiography in diagnosis of discrete subaortic membrane, to determine convenient ti...

  6. Performances of the PCA method in electrical machines diagnosis using Matlab

    OpenAIRE

    Ramahaleomiarantsoa , J.F.; Sambatra , Eric Jean Roy; Heraud , Nicolas; Razafimahenina , Jean Marie

    2012-01-01

    Nowadays, faults diagnosis is almost an inevitable step to be maintained in the optimal safety operating of every physical system. Electrical machines, main elements of every electromechanical system, are among the research topics of many academic and industrial laboratories because of the importance of their roles in the industrial process. Lots of technologies of these machines are old and well controlled. However, they remain the seat of several electrical and mechanical faults [1-4]. Thus...

  7. Clinical study on constitutional herbal tea for treating chronic fatigue.

    Science.gov (United States)

    Park, Soo-Jung; Bae, Young-Chun; Choi, Na-Rae; Ryu, Seung-Yeob; Kwon, Young-Mi; Joo, Jong-Cheon

    2014-12-01

    This study was designed to evaluate the efficacy and the safety of constitutional herbal tea for treating chronic fatigue with no diagnosed cause, which is called Mibyeong in Korea. Males and females with ages between 40 and 59 years who had complained of fatigue for 1 month consistently or for 6 months intermittently without a definite cause were recruited. At the same time, a Chalder fatigue scale (CFS) score of 19 was essential for participation in this study. Sixty five subjects completed the entire process, including blood tests and tests with medical devices. Five assessments of health status were accomplished over 8 weeks by using the CFS and the visual analogue scale (VAS). To ensure that the constitutional herbal tea was being safely used, we conducted and analyzed renal function and liver function tests. For the diagnosis of the Sasang constitution, the Sasang Constitutional Analysis Tool (SCAT) was used, and a specialist in Sasang constitutional medicine made the final diagnosis based on the SCAT result. Constitutional herbal tea was served four weeks after the first visit. The subjects took the constitutional herbal tea twice a day for one month. The results are as follows: The CFS and the VAS scores were significantly improved for the subjects in the constitutional herbal tea. No abnormalities were found on the blood tests to evaluate safety after taking the constitutional herbal tea. The improvements in the CFS and the VAS scores due to the constitutional herbal tea had no significant differences according to the Sasang constitution. Constitutional herbal tea may be used to reduce fatigue and improve health and has no adverse effect on either the kidney or the liver.

  8. Agarose cell block technique as a complementary method in the diagnosis of fungal osteomyelitis in a dog

    Directory of Open Access Journals (Sweden)

    N.S. Rocha

    2012-04-01

    Full Text Available A 7-year-old Labrador Retriever female dog presenting left forelimb lameness for one day was admitted to the Veterinary Hospital (UNESP-Botucatu for clinical evaluation. Several tests, including blood and image analysis, microbiological culture and cytology of lytic areas of affected bone were made in order to establish a diagnosis. Serum biochemical profile revealed increased levels of liver enzymes, plasma globulin, creatine kinase (CK and calcium. Hemogram revealed anemia and leukocytosis; left humerus image analysis revealed an osteolytic lesion and cytology revealed a suppurative periostitis. Differential diagnosis was a nonspecific infectious inflammatory process or osteosarcoma. Since it was not possible to achieve a definitive diagnosis and there was a highly suspicious for an infectious agent, an agarose cell block of the bone marrow fine-needle aspiration was made. The cytological examination of cell block presented similar findings as described previously. However, additional stains including periodic acid-Schiff (PAS were positive for fungal hyphae, which rendered a diagnosis of fungal osteomyelitis due to Aspergillus spp. This case report illustrates an uncommon cause of osteomyelitis for breed that was diagnosed by an underused method in veterinary medicine.

  9. Constitutional aneuploidy and cancer predisposition.

    Science.gov (United States)

    Ganmore, Ithamar; Smooha, Gil; Izraeli, Shai

    2009-04-15

    Constitutional aneuploidies are rare syndromes associated with multiple developmental abnormalities and the alterations in the risk for specific cancers. Acquired somatic chromosomal aneuploidies are the most common genetic aberrations in sporadic cancers. Thus studies of these rare constitutional aneuploidy syndromes are important not only for patient counseling and clinical management, but also for deciphering the mechanisms by which chromosomal aneuploidy affect cancer initiation and progression. Here we review the major constitutional aneuploidy syndromes and suggest some general mechanisms for the associated cancer predisposition.

  10. Economic Reforms and Constitutional Transition

    OpenAIRE

    Jeffrey D. Sachs; Wing Thye Woo; Xiaokai Yang

    2000-01-01

    This paper investigates the relationship between economic reforms and constitutional transition, which has been neglected by many transition economists. It is argued that assessment of reform performance might be very misleading if it is not recognized that economic reforms are just a small part of large scale of constitutional transition. Rivalry and competition between states and between political forces within each country are the driving forces for constitutional transition. We use Russia...

  11. ECHR and national constitutional courts

    OpenAIRE

    Nastić, Maja

    2015-01-01

    Comprising fundamental rights and freedoms and establishing the effective control system, the European Convention on Human Rights (ECHR) encroaches upon the area that is traditional reserved for constitutional law. Although built on the doctrine reserved for international treaty law, the Convention goes beyond the traditional boundaries that exist between international and constitutional law. It has gradually infiltrated into the national legal systems. Constitutional courts have had the cruc...

  12. Constitutional Issues--Watergate and the Constitution. Teaching with Documents.

    Science.gov (United States)

    National Archives and Records Administration, Washington, DC.

    When U.S. President Richard Nixon resigned in 1974 in the wake of the Watergate scandal, it was only the second time that impeachment of a president had been considered. Although the U.S. Constitution has provisions for a person removed from office to be indicted, there are no guidelines in the Constitution about a President who has resigned. The…

  13. Using the modified Delphi method to establish clinical consensus for the diagnosis and treatment of patients with rotator cuff pathology

    Directory of Open Access Journals (Sweden)

    Breda H. Eubank

    2016-05-01

    Full Text Available Abstract Background Patients presenting to the healthcare system with rotator cuff pathology do not always receive high quality care. High quality care occurs when a patient receives care that is accessible, appropriate, acceptable, effective, efficient, and safe. The aim of this study was twofold: 1 to develop a clinical pathway algorithm that sets forth a stepwise process for making decisions about the diagnosis and treatment of rotator cuff pathology presenting to primary, secondary, and tertiary healthcare settings; and 2 to establish clinical practice guidelines for the diagnosis and treatment of rotator cuff pathology to inform decision-making processes within the algorithm. Methods A three-step modified Delphi method was used to establish consensus. Fourteen experts representing athletic therapy, physiotherapy, sport medicine, and orthopaedic surgery were invited to participate as the expert panel. In round 1, 123 best practice statements were distributed to the panel. Panel members were asked to mark “agree” or “disagree” beside each statement, and provide comments. The same voting method was again used for round 2. Round 3 consisted of a final face-to-face meeting. Results In round 1, statements were grouped and reduced to 44 statements that met consensus. In round 2, five statements reached consensus. In round 3, ten statements reached consensus. Consensus was reached for 59 statements representing five domains: screening, diagnosis, physical examination, investigations, and treatment. The final face-to-face meeting was also used to develop clinical pathway algorithms (i.e., clinical care pathways for three types of rotator cuff pathology: acute, chronic, and acute-on-chronic. Conclusion This consensus guideline will help to standardize care, provide guidance on the diagnosis and treatment of rotator cuff pathology, and assist in clinical decision-making for all healthcare professionals.

  14. A method for reduction of Acoustic Emission (AE) data with application in machine failure detection and diagnosis

    Science.gov (United States)

    Vicuña, Cristián Molina; Höweler, Christoph

    2017-12-01

    The use of AE in machine failure diagnosis has increased over the last years. Most AE-based failure diagnosis strategies use digital signal processing and thus require the sampling of AE signals. High sampling rates are required for this purpose (e.g. 2 MHz or higher), leading to streams of large amounts of data. This situation is aggravated if fine resolution and/or multiple sensors are required. These facts combine to produce bulky data, typically in the range of GBytes, for which sufficient storage space and efficient signal processing algorithms are required. This situation probably explains why, in practice, AE-based methods consist mostly in the calculation of scalar quantities such as RMS and Kurtosis, and the analysis of their evolution in time. While the scalar-based approach offers the advantage of maximum data reduction; it has the disadvantage that most part of the information contained in the raw AE signal is lost unrecoverably. This work presents a method offering large data reduction, while keeping the most important information conveyed by the raw AE signal, useful for failure detection and diagnosis. The proposed method consist in the construction of a synthetic, unevenly sampled signal which envelopes the AE bursts present on the raw AE signal in a triangular shape. The constructed signal - which we call TriSignal - also permits the estimation of most scalar quantities typically used for failure detection. But more importantly, it contains the information of the time of occurrence of the bursts, which is key for failure diagnosis. Lomb-Scargle normalized periodogram is used to construct the TriSignal spectrum, which reveals the frequency content of the TriSignal and provides the same information as the classic AE envelope. The paper includes application examples in planetary gearbox and low-speed rolling element bearing.

  15. Process signal selection method to improve the impact mitigation of sensor broken for diagnosis using machine learning

    International Nuclear Information System (INIS)

    Minowa, Hirotsugu; Gofuku, Akio

    2014-01-01

    Accidents of industrial plants cause large loss on human, economic, social credibility. In recent, studies of diagnostic methods using techniques of machine learning are expected to detect early and correctly abnormality occurred in a plant. However, the general diagnostic machines are generated generally to require all process signals (hereafter, signals) for plant diagnosis. Thus if trouble occurs such as process sensor is broken, the diagnostic machine cannot diagnose or may decrease diagnostic performance. Therefore, we propose an important process signal selection method to improve impact mitigation without reducing the diagnostic performance by reducing the adverse effect of noises on multi-agent diagnostic system. The advantage of our method is the general-purpose property that allows to be applied to various supervised machine learning and to set the various parameters to decide termination of search. The experiment evaluation revealed that diagnostic machines generated by our method using SVM improved the impact mitigation and did not reduce performance about the diagnostic accuracy, the velocity of diagnosis, predictions of plant state near accident occurrence, in comparison with the basic diagnostic machine which diagnoses by using all signals. This paper reports our proposed method and the results evaluated which our method was applied to the simulated abnormal of the fast-breeder reactor Monju. (author)

  16. National constitutional courts in the European Constitutional Democracy

    DEFF Research Database (Denmark)

    Komárek, Jan

    2014-01-01

    This article critically assesses the transformation of national constitutional courts’ place in the law and politics of the EU and its member states. This process eliminates the difference between constitutional and ordinary national courts, which is crucial for the institutional implementation...... of the discourse theory of law and democracy. It also disrupts the symbiotic relationship between national constitutional democracies established after World War II and European integration. The article argues that maintaining the special place of national constitutional courts is in the vital interest of both...... the EU and its member states, understood together as the European Constitutional Democracy—the central notion developed in this article in order to support an argument that should speak to both EU lawyers and national constitutionalists....

  17. New computer-aided diagnosis of dementia using positron emission tomography: brain regional sensitivity-mapping method.

    Directory of Open Access Journals (Sweden)

    Akihiro Kakimoto

    Full Text Available PURPOSE: We devised a new computer-aided diagnosis method to segregate dementia using one estimated index (Total Z score derived from the Brodmann area (BA sensitivity map on the stereotaxic brain atlas. The purpose of this study is to investigate its accuracy to differentiate patients with Alzheimer's disease (AD or mild cognitive impairment (MCI from normal adults (NL. METHODS: We studied 101 adults (NL: 40, AD: 37, MCI: 24 who underwent (18FDG positron emission tomography (PET measurement. We divided NL and AD groups into two categories: a training group with (Category A and a test group without (Category B clinical information. In Category A, we estimated sensitivity by comparing the standard uptake value per BA (SUVR between NL and AD groups. Then, we calculated a summated index (Total Z score by utilizing the sensitivity-distribution maps and each BA z-score to segregate AD patterns. To confirm the validity of this method, we examined the accuracy in Category B. Finally, we applied this method to MCI patients. RESULTS: In Category A, we found that the sensitivity and specificity of differentiation between NL and AD were all 100%. In Category B, those were 100% and 95%, respectively. Furthermore, we found this method attained 88% to differentiate AD-converters from non-converters in MCI group. CONCLUSIONS: The present automated computer-aided evaluation method based on a single estimated index provided good accuracy for differential diagnosis of AD and MCI. This good differentiation power suggests its usefulness not only for dementia diagnosis but also in a longitudinal study.

  18. New Computer-Aided Diagnosis of Dementia Using Positron Emission Tomography: Brain Regional Sensitivity-Mapping Method

    Science.gov (United States)

    Kakimoto, Akihiro; Kamekawa, Yuichi; Ito, Shigeru; Yoshikawa, Etsuji; Okada, Hiroyuki; Nishizawa, Sadahiko; Minoshima, Satoshi; Ouchi, Yasuomi

    2011-01-01

    Purpose We devised a new computer-aided diagnosis method to segregate dementia using one estimated index (Total Z score) derived from the Brodmann area (BA) sensitivity map on the stereotaxic brain atlas. The purpose of this study is to investigate its accuracy to differentiate patients with Alzheimer's disease (AD) or mild cognitive impairment (MCI) from normal adults (NL). Methods We studied 101 adults (NL: 40, AD: 37, MCI: 24) who underwent 18FDG positron emission tomography (PET) measurement. We divided NL and AD groups into two categories: a training group with (Category A) and a test group without (Category B) clinical information. In Category A, we estimated sensitivity by comparing the standard uptake value per BA (SUVR) between NL and AD groups. Then, we calculated a summated index (Total Z score) by utilizing the sensitivity-distribution maps and each BA z-score to segregate AD patterns. To confirm the validity of this method, we examined the accuracy in Category B. Finally, we applied this method to MCI patients. Results In Category A, we found that the sensitivity and specificity of differentiation between NL and AD were all 100%. In Category B, those were 100% and 95%, respectively. Furthermore, we found this method attained 88% to differentiate AD-converters from non-converters in MCI group. Conclusions The present automated computer-aided evaluation method based on a single estimated index provided good accuracy for differential diagnosis of AD and MCI. This good differentiation power suggests its usefulness not only for dementia diagnosis but also in a longitudinal study. PMID:21966405

  19. Evaluation of an advanced physical diagnosis course using consumer preferences methods: the nominal group technique.

    Science.gov (United States)

    Coker, Joshua; Castiglioni, Analia; Kraemer, Ryan R; Massie, F Stanford; Morris, Jason L; Rodriguez, Martin; Russell, Stephen W; Shaneyfelt, Terrance; Willett, Lisa L; Estrada, Carlos A

    2014-03-01

    Current evaluation tools of medical school courses are limited by the scope of questions asked and may not fully engage the student to think on areas to improve. The authors sought to explore whether a technique to study consumer preferences would elicit specific and prioritized information for course evaluation from medical students. Using the nominal group technique (4 sessions), 12 senior medical students prioritized and weighed expectations and topics learned in a 100-hour advanced physical diagnosis course (4-week course; February 2012). Students weighted their top 3 responses (top = 3, middle = 2 and bottom = 1). Before the course, 12 students identified 23 topics they expected to learn; the top 3 were review sensitivity/specificity and high-yield techniques (percentage of total weight, 18.5%), improving diagnosis (13.8%) and reinforce usual and less well-known techniques (13.8%). After the course, students generated 22 topics learned; the top 3 were practice and reinforce advanced maneuvers (25.4%), gaining confidence (22.5%) and learn the evidence (16.9%). The authors observed no differences in the priority of responses before and after the course (P = 0.07). In a physical diagnosis course, medical students elicited specific and prioritized information using the nominal group technique. The course met student expectations regarding education of the evidence-based physical examination, building skills and confidence on the proper techniques and maneuvers and experiential learning. The novel use for curriculum evaluation may be used to evaluate other courses-especially comprehensive and multicomponent courses.

  20. Iatrogenic femoral artery pseudoaneurysms - A review of current methods of diagnosis and treatment

    Energy Technology Data Exchange (ETDEWEB)

    Ahmad, F. [Department of Interventional Radiology, Royal Berkshire NHS Foundation Trust, Reading (United Kingdom)], E-mail: farhan@doctors.org.uk; Turner, S.A.; Torrie, P.; Gibson, M. [Department of Interventional Radiology, Royal Berkshire NHS Foundation Trust, Reading (United Kingdom)

    2008-12-15

    The common femoral artery is commonly used as arterial access for a wide range of radiological and cardiological procedures. Pseudoaneurysm formation is the most common arterial complication of femoral artery catheterization, and is diagnosed using colour Doppler ultrasound. Ultrasound-guided thrombin injection has replaced ultrasound-guided compression as the first-line treatment. The practicalities of thrombin injection (technique and types of thrombin available) and other treatment options are discussed. Awareness of pseudoaneurysm formation and the treatment options allows prompt diagnosis and successful treatment.

  1. Comparison of alternative weight recalibration methods for diagnosis-related groups

    Science.gov (United States)

    Rogowski, Jeannette Roskamp; Byrne, Daniel J.

    1990-01-01

    In this article, alternative methodologies for recalibration of the diagnosis-related group (DRG) weights are examined. Based on 1984 data, cost and charge-based weights are less congruent than those calculated with 1981 data. Previous studies using 1981 data demonstrated that cost- and charge-based weights were not very different. Charge weights result in higher payments to surgical DRGs and lower payments to medical DRGs, relative to cost weights. At the provider level, charge weights result in higher payments to large urban hospitals and teaching hospitals, relative to cost weights. PMID:10113568

  2. Iatrogenic femoral artery pseudoaneurysms - A review of current methods of diagnosis and treatment

    International Nuclear Information System (INIS)

    Ahmad, F.; Turner, S.A.; Torrie, P.; Gibson, M.

    2008-01-01

    The common femoral artery is commonly used as arterial access for a wide range of radiological and cardiological procedures. Pseudoaneurysm formation is the most common arterial complication of femoral artery catheterization, and is diagnosed using colour Doppler ultrasound. Ultrasound-guided thrombin injection has replaced ultrasound-guided compression as the first-line treatment. The practicalities of thrombin injection (technique and types of thrombin available) and other treatment options are discussed. Awareness of pseudoaneurysm formation and the treatment options allows prompt diagnosis and successful treatment

  3. Modification of the Integrated Sasang Constitutional Diagnostic Model

    Directory of Open Access Journals (Sweden)

    Jiho Nam

    2017-01-01

    Full Text Available In 2012, the Korea Institute of Oriental Medicine proposed an objective and comprehensive physical diagnostic model to address quantification problems in the existing Sasang constitutional diagnostic method. However, certain issues have been raised regarding a revision of the proposed diagnostic model. In this paper, we propose various methodological approaches to address the problems of the previous diagnostic model. Firstly, more useful variables are selected in each component. Secondly, the least absolute shrinkage and selection operator is used to reduce multicollinearity without the modification of explanatory variables. Thirdly, proportions of SC types and age are considered to construct individual diagnostic models and classify the training set and the test set for reflecting the characteristics of the entire dataset. Finally, an integrated model is constructed with explanatory variables of individual diagnosis models. The proposed integrated diagnostic model significantly improves the sensitivities for both the male SY type (36.4% → 62.0% and the female SE type (43.7% → 64.5%, which were areas of limitation of the previous integrated diagnostic model. The ideas of these new algorithms are expected to contribute not only to the scientific development of Sasang constitutional medicine in Korea but also to that of other diagnostic methods for traditional medicine.

  4. Comparison of the prevalence of malnutrition diagnosis in head and neck, gastrointestinal and lung cancer patients by three classification methods

    Science.gov (United States)

    Platek, Mary E.; Popp KPf, Johann V.; Possinger, Candi S.; DeNysschen, Carol A.; Horvath, Peter; Brown, Jean K.

    2011-01-01

    Background Malnutrition is prevalent among patients within certain cancer types. There is lack of universal standard of care for nutrition screening, lack of agreement on an operational definition and on validity of malnutrition indicators. Objective In a secondary data analysis, we investigated prevalence of malnutrition diagnosis by three classification methods using data from medical records of a National Cancer Institute (NCI)-designated comprehensive cancer center. Interventions/Methods Records of 227 patients hospitalized during 1998 with head and neck, gastrointestinal or lung cancer were reviewed for malnutrition based on three methods: 1) physician diagnosed malnutrition related ICD-9 codes; 2) in-hospital nutritional assessment summary conducted by Registered Dietitians; and 3) body mass index (BMI). For patients with multiple admissions, only data from the first hospitalization was included. Results Prevalence of malnutrition diagnosis ranged from 8.8% based on BMI to approximately 26% of all cases based on dietitian assessment. Kappa coefficients between any methods indicated a weak (kappa=0.23, BMI and Dietitians and kappa=0.28, Dietitians and Physicians) to fair strength of agreement (kappa=0.38, BMI and Physicians). Conclusions Available methods to identify patients with malnutrition in an NCI designated comprehensive cancer center resulted in varied prevalence of malnutrition diagnosis. Universal standard of care for nutrition screening that utilizes validated tools is needed. Implications for Practice The Joint Commission on the Accreditation of Healthcare Organizations requires nutritional screening of patients within 24 hours of admission. For this purpose, implementation of a validated tool that can be used by various healthcare practitioners, including nurses, needs to be considered. PMID:21242767

  5. Complex radiological diagnosis and choice of a method of surgical treatment of the lung and the liver hydatidosis

    International Nuclear Information System (INIS)

    Ikramov, A.I.

    2003-01-01

    In dissertation work there were analyzed results of diagnosis and surgical treatment 1.741 patients with lung and liver hydatidosis. The investigations were executed with application of a complex of radiologic methods such X-ray, sonography, CT and MRI tomography. Were analyzed separate and cumulative information of the listed methods on the basis of their sensitivity, specificity and general accuracy. The questions of classification of complicated forms of the lung hydatidosis and criteria to differential diagnosis of spherical lung formations and liver focal formations are discussed. The technique of transthoracic sonography for revealing and differential diagnostics subpleural localization of the hydatidosis and congestions of a liquid in pleural cavity is developed. The indications and contraindications to use transcutaneus fine needle biopsy for diagnostics of the hydatidosis are determined. On the basis of results of complex X-ray diagnostics the original algorithms of a sequence of performance various methods of visualization are developed. The indications to performance pancreatocholangiography are proved at suspicion on ruptured hydatid cysts into biliar tract with mechanical jaundice. The analysis of results of traditional surgical treatment of the hydatidosis, and low invasive transcutaneus procedures, endovisual surgical operations and chemotherapy is carried out. The indications to performance of the listed methods are developed depending on the form and stage of disease, localization of cysts. Were analyzed results of transcutaneus aspiration and drainage of residual cavities after hydatidectomy. The comparative estimation to traditional surgical methods, CT- and US-guided transcutaneus aspirations, drainage is given. Are determined a role and place of complex radiological diagnosis with use sonography, X-ray and CT in early and late postoperative complications after hydatidectomy from the lung and liver (pleural effusion, subdiaphragmal abscess and

  6. Application of an immunoassay method to improve the diagnosis and control of African trypanosomosis. Proceedings of the workshop

    International Nuclear Information System (INIS)

    1997-02-01

    The Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture supports the introduction and use of nuclear and related techniques in developing countries through co-ordinated research programmes. A co-ordinated research programme (CRP) entitled ''Improving the diagnosis and control of trypanosomosis and other research programme (CRP) entitled ''Improving the diagnosis and control of trypanosomosis and other vector-borne diseases of African livestock using immunoassay methods'' was executed from 1987 to 1993 with funding from the Directorate General of Development Co-operation (DGIS) of the Netherlands. A total of 12 reports by the various Research Contract holders were compiled and published as a Technical Document (IAEA-TECDOC-707) together with conclusions, recommendations and reports by experts in the field. Refs, figs tabs

  7. Application of an immunoassay method to improve the diagnosis and control of African trypanosomosis. Proceedings of the workshop

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-02-01

    The Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture supports the introduction and use of nuclear and related techniques in developing countries through co-ordinated research programmes. A co-ordinated research programme (CRP) entitled ``Improving the diagnosis and control of trypanosomosis and other research programme (CRP) entitled ``Improving the diagnosis and control of trypanosomosis and other vector-borne diseases of African livestock using immunoassay methods`` was executed from 1987 to 1993 with funding from the Directorate General of Development Co-operation (DGIS) of the Netherlands. A total of 12 reports by the various Research Contract holders were compiled and published as a Technical Document (IAEA-TECDOC-707) together with conclusions, recommendations and reports by experts in the field. Refs, figs tabs.

  8. Influence of antibiotic therapy prior to admission on the efficacy of classical methods for the diagnosis of meningococcal disease.

    Science.gov (United States)

    Nemescu, Roxana Elena; Iancu, Luminiţa Smaranda; Dorneanu, Olivia Simona; Ursu, Ramona Gabriela; Dorobăţ, Carmen Mihaela

    2014-01-01

    To assess the influence of preadmission antibiotic therapy on the results of the classical methods for bacteriological confirmation of meningococcal disease (MD). Retrospective study of the MD cases diagnosed in the "St. Parascheva" Universitary Clinical Infectious Diseases Iaşi between 1994 and 2011. The etiological diagnosis was made by identifying the meningococcus in the CSF (cerebrospinal fluid) in 71.9% of the 323 patients and by blood culture in 8%. Preadmission antibiotic therapy received 39% of the patients, thus the sensitivity of test was significantly reduced: direct examination from 64.6% to 43.2% (p antibiotic therapy significantly increased the ratio of cases in which meningococcus was not detected in CSF by any of the classical methods (44% compared to 17.9% in the cases without prior treatment). The proportion of cases in which meningococcal isolation was done by two methods decreased from 38.5% to 19.2%, and of those by all three methods from 16.9% to 5.6% (p antibiotic therapy also decreased the rate of positive blood cultures from 14.7% to 3.5% (Fisher's exact test, p = 0.009). Antibiotic treatment prior to admission significantly decreases the percentage of patients with MD in which meningococcal isolation can be done; this requires the use of a more sensitive diagnosis method (ex. qPCR).

  9. Methods for Probabilistic Fault Diagnosis: An Electrical Power System Case Study

    Science.gov (United States)

    Ricks, Brian W.; Mengshoel, Ole J.

    2009-01-01

    Health management systems that more accurately and quickly diagnose faults that may occur in different technical systems on-board a vehicle will play a key role in the success of future NASA missions. We discuss in this paper the diagnosis of abrupt continuous (or parametric) faults within the context of probabilistic graphical models, more specifically Bayesian networks that are compiled to arithmetic circuits. This paper extends our previous research, within the same probabilistic setting, on diagnosis of abrupt discrete faults. Our approach and diagnostic algorithm ProDiagnose are domain-independent; however we use an electrical power system testbed called ADAPT as a case study. In one set of ADAPT experiments, performed as part of the 2009 Diagnostic Challenge, our system turned out to have the best performance among all competitors. In a second set of experiments, we show how we have recently further significantly improved the performance of the probabilistic model of ADAPT. While these experiments are obtained for an electrical power system testbed, we believe they can easily be transitioned to real-world systems, thus promising to increase the success of future NASA missions.

  10. Constitutive Effects of Performance Indicators

    DEFF Research Database (Denmark)

    Dahler-Larsen, Peter

    2014-01-01

    that are demonstrably problematic. Based on a distinction between trivial and advanced measure fixation, an argument is made for constitutive effects that are based on less problematic assumptions. Through this conceptual move, the political dimension of performance indicators is appreciated. The conceptual dimensions...... of constitutive effects are carved out, empirical illustrations of their applicability are offered and implications discussed....

  11. Using the modified Delphi method to establish clinical consensus for the diagnosis and treatment of patients with rotator cuff pathology.

    Science.gov (United States)

    Eubank, Breda H; Mohtadi, Nicholas G; Lafave, Mark R; Wiley, J Preston; Bois, Aaron J; Boorman, Richard S; Sheps, David M

    2016-05-20

    Patients presenting to the healthcare system with rotator cuff pathology do not always receive high quality care. High quality care occurs when a patient receives care that is accessible, appropriate, acceptable, effective, efficient, and safe. The aim of this study was twofold: 1) to develop a clinical pathway algorithm that sets forth a stepwise process for making decisions about the diagnosis and treatment of rotator cuff pathology presenting to primary, secondary, and tertiary healthcare settings; and 2) to establish clinical practice guidelines for the diagnosis and treatment of rotator cuff pathology to inform decision-making processes within the algorithm. A three-step modified Delphi method was used to establish consensus. Fourteen experts representing athletic therapy, physiotherapy, sport medicine, and orthopaedic surgery were invited to participate as the expert panel. In round 1, 123 best practice statements were distributed to the panel. Panel members were asked to mark "agree" or "disagree" beside each statement, and provide comments. The same voting method was again used for round 2. Round 3 consisted of a final face-to-face meeting. In round 1, statements were grouped and reduced to 44 statements that met consensus. In round 2, five statements reached consensus. In round 3, ten statements reached consensus. Consensus was reached for 59 statements representing five domains: screening, diagnosis, physical examination, investigations, and treatment. The final face-to-face meeting was also used to develop clinical pathway algorithms (i.e., clinical care pathways) for three types of rotator cuff pathology: acute, chronic, and acute-on-chronic. This consensus guideline will help to standardize care, provide guidance on the diagnosis and treatment of rotator cuff pathology, and assist in clinical decision-making for all healthcare professionals.

  12. Political dimension of European constitutionalism

    Directory of Open Access Journals (Sweden)

    Kaplánová Patricia

    2015-04-01

    Full Text Available Author in the article tries to analyse different elements of document called European Constitution. Analysis is supported with theoretical framework of federalism, presented by Brezovšek. Authors is playing with idea of (confederal and international organization elements of European Constitution and their mix. They are also trying to set some connections between so called common European identity as necessary condition to give legitimacy to the European Constitution. This became important question after „votes of non-confidence“ to the European Constitution in France, despite it should be addressed already before. However, European Constitution is important document on the path of European integration and lack of support to it will slow down this process of widening and deepening European ties.

  13. [Comparison of manual and automated (MagNA Pure) nucleic acid isolation methods in molecular diagnosis of HIV infections].

    Science.gov (United States)

    Alp, Alpaslan; Us, Dürdal; Hasçelik, Gülşen

    2004-01-01

    Rapid quantitative molecular methods are very important for the diagnosis of human immunodeficiency virus (HIV) infections, assessment of prognosis and follow up. The purpose of this study was to compare and evaluate the performances of conventional manual extraction method and automated MagNA Pure system, for the nucleic acid isolation step which is the first and most important step in molecular diagnosis of HIV infections. Plasma samples of 35 patients in which anti-HIV antibodies were found as positive by microparticule enzyme immunoassay and confirmed by immunoblotting method, were included in the study. The nucleic acids obtained simultaneously by manual isolation kit (Cobas Amplicor, HIV-1 Monitor Test, version 1.5, Roche Diagnostics) and automated system (MagNA Pure LC Total Nucleic Acid Isolation Kit, Roche Diagnostics), were amplified and detected in Cobas Amplicor (Roche Diagnostics) instrument. Twenty three of 35 samples (65.7%) were found to be positive, and 9 (25.7%) were negative by both of the methods. The agreement between the methods were detected as 91.4%, for qualitative results. Viral RNA copies detected by manual and MagNA Pure isolation methods were found between 76.0-7.590.000 (mean: 487.143) and 113.0-20.300.0000 (mean: 2.174.097) copies/ml, respectively. When both of the overall and individual results were evaluated, the number of RNA copies obtained with automatized system, were found higher than the manual method (p<0.05). Three samples which had low numbers of nucleic acids (113, 773, 857, respectively) with MagNA Pure, yielded negative results with manual method. In conclusion, the automatized MagNA Pure system was found to be a reliable, rapid and practical method for the isolation of HIV-RNA.

  14. Study on intelligence fault diagnosis method for nuclear power plant equipment based on rough set and fuzzy neural network

    International Nuclear Information System (INIS)

    Liu Yongkuo; Xia Hong; Xie Chunli; Chen Zhihui; Chen Hongxia

    2007-01-01

    Rough set theory and fuzzy neural network are combined, to take full advantages of the two of them. Based on the reduction technology to knowledge of Rough set method, and by drawing the simple rule from a large number of initial data, the fuzzy neural network was set up, which was with better topological structure, improved study speed, accurate judgment, strong fault-tolerant ability, and more practical. In order to test the validity of the method, the inverted U-tubes break accident of Steam Generator and etc are used as examples, and many simulation experiments are performed. The test result shows that it is feasible to incorporate the fault intelligence diagnosis method based on rough set and fuzzy neural network in the nuclear power plant equipment, and the method is simple and convenience, with small calculation amount and reliable result. (authors)

  15. Statistical time series methods for damage diagnosis in a scale aircraft skeleton structure: loosened bolts damage scenarios

    International Nuclear Information System (INIS)

    Kopsaftopoulos, Fotis P; Fassois, Spilios D

    2011-01-01

    A comparative assessment of several vibration based statistical time series methods for Structural Health Monitoring (SHM) is presented via their application to a scale aircraft skeleton laboratory structure. A brief overview of the methods, which are either scalar or vector type, non-parametric or parametric, and pertain to either the response-only or excitation-response cases, is provided. Damage diagnosis, including both the detection and identification subproblems, is tackled via scalar or vector vibration signals. The methods' effectiveness is assessed via repeated experiments under various damage scenarios, with each scenario corresponding to the loosening of one or more selected bolts. The results of the study confirm the 'global' damage detection capability and effectiveness of statistical time series methods for SHM.

  16. Analysis of the discriminative methods for diagnosis of benign and malignant solitary pulmonary nodules based on serum markers.

    Science.gov (United States)

    Wang, Wanping; Liu, Mingyue; Wang, Jing; Tian, Rui; Dong, Junqiang; Liu, Qi; Zhao, Xianping; Wang, Yuanfang

    2014-01-01

    Screening indexes of tumor serum markers for benign and malignant solitary pulmonary nodules (SPNs) were analyzed to find the optimum method for diagnosis. Enzyme-linked immunosorbent assays, an automatic immune analyzer and radioimmunoassay methods were used to examine the levels of 8 serum markers in 164 SPN patients, and the sensitivity for differential diagnosis of malignant or benign SPN was compared for detection using a single plasma marker or a combination of markers. The results for serological indicators that closely relate to benign and malignant SPNs were screened using the Fisher discriminant analysis and a non-conditional logistic regression analysis method, respectively. The results were then verified by the k-means clustering analysis method. The sensitivity when using a combination of serum markers to detect SPN was higher than that using a single marker. By Fisher discriminant analysis, cytokeratin 19 fragments (CYFRA21-1), carbohydrate antigen 125 (CA125), squamous cell carcinoma antigen (SCC) and breast cancer antigen (CA153), which relate to the benign and malignant SPNs, were screened. Through non-conditional logistic regression analysis, CYFRA21-1, SCC and CA153 were obtained. Using the k-means clustering analysis, the cophenetic correlation coefficient (0.940) obtained by the Fisher discriminant analysis was higher than that obtained with logistic regression analysis (0.875). This study indicated that the Fisher discriminant analysis functioned better in screening out serum markers to recognize the benign and malignant SPN. The combined detection of CYFRA21-1, CA125, SCC and CA153 is an effective way to distinguish benign and malignant SPN, and will find an important clinical application in the early diagnosis of SPN. © 2014 S. Karger GmbH, Freiburg.

  17. A noninvasive method for coronary artery diseases diagnosis using a clinically-interpretable fuzzy rule-based system

    Directory of Open Access Journals (Sweden)

    Hamid Reza Marateb

    2015-01-01

    Full Text Available Background: Coronary heart diseases/coronary artery diseases (CHDs/CAD, the most common form of cardiovascular disease (CVD, are a major cause for death and disability in developing/developed countries. CAD risk factors could be detected by physicians to prevent the CAD occurrence in the near future. Invasive coronary angiography, a current diagnosis method, is costly and associated with morbidity and mortality in CAD patients. The aim of this study was to design a computer-based noninvasive CAD diagnosis system with clinically interpretable rules. Materials and Methods: In this study, the Cleveland CAD dataset from the University of California UCI (Irvine was used. The interval-scale variables were discretized, with cut points taken from the literature. A fuzzy rule-based system was then formulated based on a neuro-fuzzy classifier (NFC whose learning procedure was speeded up by the scaled conjugate gradient algorithm. Two feature selection (FS methods, multiple logistic regression (MLR and sequential FS, were used to reduce the required attributes. The performance of the NFC (without/with FS was then assessed in a hold-out validation framework. Further cross-validation was performed on the best classifier. Results: In this dataset, 16 complete attributes along with the binary CHD diagnosis (gold standard for 272 subjects (68% male were analyzed. MLR + NFC showed the best performance. Its overall sensitivity, specificity, accuracy, type I error (α and statistical power were 79%, 89%, 84%, 0.1 and 79%, respectively. The selected features were "age and ST/heart rate slope categories," "exercise-induced angina status," fluoroscopy, and thallium-201 stress scintigraphy results. Conclusion: The proposed method showed "substantial agreement" with the gold standard. This algorithm is thus, a promising tool for screening CAD patients.

  18. Significance of roentgenologic and nuclear medicine methods in diagnosis and operative indications of coronary artery disease

    Energy Technology Data Exchange (ETDEWEB)

    Felix, R [Bonn Univ. (F.R. Germany). Radiologische Klinik; Winkler, C [Bonn Univ. (F.R. Germany). Inst. fuer Klinische und Experimentelle Nuklearmedizin; Schaede, A [Bonn Univ. (F.R. Germany). Medizinische Klinik

    1976-03-01

    Significance and technique of roentgenologic and nuclear medicine methods for evaluation of coronary artery disease and myocardial perfusion are presented. Some routinely used methods in nuclear medicine are briefly discussed concerning the evaluation of left ventricular function.

  19. Diagnostic accuracy of scintigraphic methods in the differential diagnosis of focal liver lesions

    International Nuclear Information System (INIS)

    Czermak, H.; Gomez, I.; Gallowitsch, H.J.; Lind, P.

    1993-01-01

    In a retrospective study of 160 patients who were examined within 12 months, we analysed the diagnosic value of scintigraphic techniques in the differential diagnosis of solid focal liver lesions. Haemangiomas were found in 77 patients. Bloodpool scintigraphy was true-positive in 66 (sensivitity 85%); for lesions greater than 2 cm in diameter, sensitivity increased to 94%. Metastases of CEA-expressing tumors were found in 42 patients, anti-CEA-immunoscintigraphy was true-positive in 33 patients (sensitivity 78.5%). Focal nodulary hyperplasia was found in 3 patients, adenomas in 6 patients. In the remaining 32 patiens we saw 4 hepatocellular carcinomas, 28 metastases from lung and breast cancer, 2 echinococcus cysts and 1 choledochus cyst. (orig.) [de

  20. Diapo, applying advanced AI methods to diagnosis of PWR reactor coolant pump

    International Nuclear Information System (INIS)

    Porcheron, M.; Ricard, B.

    1993-01-01

    Electricite de France has decided to increase the capabilities of its monitoring and diagnostic architecture with the development of an AI system for reactor coolant pump diagnostic support. This development is carried out with the cooperation of the equipment constructor Jeumont Schneider Industries. This diagnostic system will eventually be included in an integrated surveillance architecture. We present the architecture of the system and the basics of the knowledge model used. Main data for diagnosis are provided by sensor data issued by the pump monitoring system. Diagnostic reasoning is based on the cooperation of two main activities : a heuristic search among typical symptomatic situations that leads to the formulation of hypotheses and a ''deep'' causal analysis that consists in backtracking from identified situations up to initial faults or causes. This approach is well fitted to field expert reasoning, and provides powerful diagnostic capabilities that help to overcome conventional limitations of expert systems entirely based on heuristic knowledge. (authors). 9 figs., 11 refs

  1. Statistical Diagnosis of the Best Weibull Methods for Wind Power Assessment for Agricultural Applications

    Directory of Open Access Journals (Sweden)

    Abul Kalam Azad

    2014-05-01

    Full Text Available The best Weibull distribution methods for the assessment of wind energy potential at different altitudes in desired locations are statistically diagnosed in this study. Seven different methods, namely graphical method (GM, method of moments (MOM, standard deviation method (STDM, maximum likelihood method (MLM, power density method (PDM, modified maximum likelihood method (MMLM and equivalent energy method (EEM were used to estimate the Weibull parameters and six statistical tools, namely relative percentage of error, root mean square error (RMSE, mean percentage of error, mean absolute percentage of error, chi-square error and analysis of variance were used to precisely rank the methods. The statistical fittings of the measured and calculated wind speed data are assessed for justifying the performance of the methods. The capacity factor and total energy generated by a small model wind turbine is calculated by numerical integration using Trapezoidal sums and Simpson’s rules. The results show that MOM and MLM are the most efficient methods for determining the value of k and c to fit Weibull distribution curves.

  2. Comparison of three methods for gastrointestinal nematode diagnosis determination in grazing dairy cattle in relation to milk production.

    Science.gov (United States)

    Mejía, M E; Perri, A F; Licoff, N; Miglierina, M M; Cseh, S; Ornstein, A M; Becu-Villalobos, D; Lacau-Mengido, I M

    2011-12-29

    Development of resistance to anthelmintic drugs has motivated the search for diagnostic methods to identify animals for targeted selective treatments. We compared three methods for the diagnosis of nematode infection in relation to milk production in a fully grazing dairy herd of 150 cows in the humid Pampa (Argentina). Animals had feces, blood and milk sampled during the first postpartum month for EPG, pepsinogen and anti-Ostertagia antibody determination, respectively. With the results obtained two groups of cows, divided in high and low parasite burden, were conformed for each method, and milk production was then compared between groups. When cows were separated by the EPG method (EPG=0 (N=106) vs. EPG>0 (N=44)) a difference of nearly 800 l of milk per cow per lactation was found (P 1000) or by anti-Ostertagia (ODR ≤ 0.5 vs. ODR > 0.5) results did not differ. Interestingly, proportion of cows in each group differed between methods (P<0.0001), and the anti-Ostertagia method yielded significantly more cows in the high index group compared to results using the EPG or Pepsinogen method. No correlations were found between parasite indexes determined by the different methods. High parasite burden estimation found may be ascribed to the production system, fully grazing all year round, and to the sampling time, at the beginning of lactation with cows in negative energy balance and depressed immunity. The fact that the cows were born and reared outside, on pasture with continuous nematode larvae exposure, may also account for the results obtained. In conclusion, EPG counting during the first postpartum month may be a useful tool for the diagnosis of production impairment induced by high nematode burden in adult grazing dairy cows. The anthelmintic treatment of only the EPG-positive recently calved cows would improve milk production, while reducing selective pressure on nematode population for the development of resistance. Copyright © 2011 Elsevier B.V. All rights

  3. Vegetative-vascular dystonia: diagnosis and treatment with the inclusion of modern methods of physiotherapy

    Directory of Open Access Journals (Sweden)

    N. I. Samosyuk

    2015-07-01

      В статье рассматриваются вопросы нейроциркуляторной дистонии и вегетативно-сосудистой дистонии, нозологическая принадлежность которых широко дискутируется в литературе. Авторы показывают в данной работе формирование клинического представления от «ВСД» и «НЦД», приводят классификацию, особенности их клинического течения и методики современной физиотерапии. Статья может представлять интерес широкому кругу врачей: неврологам, терапевтам, семейным врачам, врачам общей практики, студентам старших курсов медицинских ВУЗов и др.   Ключевые слова: вегетативно-сосудистая дистония, вегето-сосудистая дистония, диагностика, лечение, физиотерапия.   Abstract   The article discusses using neuro-circulator dystonia and vegetative-vascular dystonia, nosologic belonging which is widely discussed in the literature. In this paper, the authors show the formation of the clinical presentation of "VCD" and "NCD", lead classification, peculiarities of their clinical evolution and modern methods of physiotherapy. The article may be of interest to a wide range of doctors: neurologists, general practitioners, family doctors, physicians, undergraduate students of medical universities, etc.   Key words: vegetative-vascular dystonia, vegeto-vascular dystonia, diagnosis, treatment, physiotherapy.     Содержание   Вступление Соматоформные расстройства Лечение расстройств,

  4. Optimizing culture medium for debittering constitutive enzyme ...

    African Journals Online (AJOL)

    The objective of this study was to investigate nutrient requirements for extracellular constitutive naringinase production by Aspergillus oryzae JMU316. The one-factor-at-a-time method was used to determine the impact of different carbon and nitrogen sources on naringinase production. Naringin exhibited the highest ...

  5. A cross-validation Delphi method approach to the diagnosis and treatment of personality disorders in older adults.

    Science.gov (United States)

    Rosowsky, Erlene; Young, Alexander S; Malloy, Mary C; van Alphen, S P J; Ellison, James M

    2018-03-01

    The Delphi method is a consensus-building technique using expert opinion to formulate a shared framework for understanding a topic with limited empirical support. This cross-validation study replicates one completed in the Netherlands and Belgium, and explores US experts' views on the diagnosis and treatment of older adults with personality disorders (PD). Twenty-one geriatric PD experts participated in a Delphi survey addressing diagnosis and treatment of older adults with PD. The European survey was translated and administered electronically. First-round consensus was reached for 16 out of 18 items relevant to diagnosis and specific mental health programs for personality disorders in older adults. Experts agreed on the usefulness of establishing criteria for specific types of treatments. The majority of psychologists did not initially agree on the usefulness of pharmacotherapy. Expert consensus was reached following two subsequent rounds after clarification addressing medication use. Study results suggest consensus among regarding psychosocial treatments. Limited acceptance amongst US psychologists about the suitability of pharmacotherapy for late-life PDs contrasted with the views expressed by experts surveyed in Netherlands and Belgium studies.

  6. Radioactive waste disposal and constitution

    International Nuclear Information System (INIS)

    Stober, R.

    1983-01-01

    The radioactive waste disposal has many dimensions with regard to the constitutional law. The central problem is the corret delimitation between adequate governmental precautions against risks and or the permitted risk which the state can impose on the citizen, and the illegal danger which nobody has to accept. The solution requires to consider all aspects which are relevant to the constitutional law. Therefore, the following analysis deals not only with the constitutional risks and the risks of the nuclear energy, but also with the liberal, overall-economic, social, legal, and democratic aspects of radioactive waste disposal. (HSCH) [de

  7. Constitutional aneuploidy and cancer predisposition†

    Science.gov (United States)

    Ganmore, Ithamar; Smooha, Gil; Izraeli, Shai

    2009-01-01

    Constitutional aneuploidies are rare syndromes associated with multiple developmental abnormalities and the alterations in the risk for specific cancers. Acquired somatic chromosomal aneuploidies are the most common genetic aberrations in sporadic cancers. Thus studies of these rare constitutional aneuploidy syndromes are important not only for patient counseling and clinical management, but also for deciphering the mechanisms by which chromosomal aneuploidy affect cancer initiation and progression. Here we review the major constitutional aneuploidy syndromes and suggest some general mechanisms for the associated cancer predisposition. PMID:19297405

  8. Methods and equipment for diagnosis of components of Novovoronezh nuclear power plant

    Energy Technology Data Exchange (ETDEWEB)

    Prokop, K [Energoinvest, Dukovany (Czechoslovakia). Zavod Jaderna Elektrarna

    1981-12-01

    The results are reported obtained in applying diagnostic techniques adn diagnostic equipment in the Novovoronezh nuclear power plant. Vibroacoustic, neutron and hydrodynamic noiose of the installation was monitored. The test level method and the mean value comparison method were used for assessing the installation condition. Dispersion analysis methods are used for predicting the propagation of anomalies while for determining specific defects leading to the formation of anomalies the method is used based on the correlation analysis of vibroacoustic signals and other technological noise. The flow charts and descriptions are given of the systems of acoustic emission testing, reactor internals testing using neutron noise, pump testing, and the spectral analyzer.

  9. Use of radionuclide method in preoperative and intraoperative diagnosis of osteoid osteoma of the spine. Case report

    International Nuclear Information System (INIS)

    Israeli, A.; Zwas, S.T.; Horoszowski, H.; Farine, I.

    1983-01-01

    A 24-year-old man with persistent low back pain and right sciatica, was found to have an osteoid osteoma of the right pedicle of the second lumbar vertebra. /sup 99m/Tc-MDP bone scan and CAT scan produced an early diagnosis of the lesion. Intraoperative /sup 99m/Tc-MDP in vitro combined with imaging and quantitative activity measurements were useful for accurate localization and complete removal. The method is simple and can be performed in every nuclear medicine department, with no need for special operating room facilities

  10. The significance of imaging methods in the diagnosis of periarticular diseases of the shoulder caused by sports injuries

    International Nuclear Information System (INIS)

    Reichelt, A.

    1989-01-01

    Numerous kinds of sports lead to lesions of the periarticular tissue of the shoulder, which can result in the supraspinatus syndrome or incomplete and complete rupture of the rotator cuff. Standard radiography is of limited use in the diagnosis of periarticular diseases of the shoulder. Osseous alterations in the greater tubercle and undersurface of the acromion can be explained as a supraspinatus syndrome or a long-standing rupture of the rotator cuff in connection with high positioning of the head of the humerus. A rupture of the rotator cuff is demonstrated by arthrography of the shoulder joint, a diagnostic method that we think is necessary despite regular examinations with ultrasonography. (orig.) [de

  11. Adaptive Multiscale Noise Control Enhanced Stochastic Resonance Method Based on Modified EEMD with Its Application in Bearing Fault Diagnosis

    Directory of Open Access Journals (Sweden)

    Jimeng Li

    2016-01-01

    Full Text Available The structure of mechanical equipment becomes increasingly complex, and tough environments under which it works often make bearings and gears subject to failure. However, effective extraction of useful feature information submerged in strong noise that is indicative of structural defects has remained a major challenge. Therefore, an adaptive multiscale noise control enhanced stochastic resonance (SR method based on modified ensemble empirical mode decomposition (EEMD for mechanical fault diagnosis is proposed in the paper. According to the oscillation characteristics of signal itself, the algorithm of modified EEMD can adaptively decompose the fault signals into different scales and it reduces the decomposition levels to improve calculation efficiency of the proposed method. Through filter processing with the constructed filters, the orthogonality of adjacent intrinsic mode functions (IMFs can be improved, which is conducive to enhancing the extraction of weak features from strong noise. The constructed signal obtained by using IMFs is inputted into the SR system, and the noise control parameter of different scales is optimized and selected with the help of the genetic algorithm, thus achieving the enhancement extraction of weak features. Finally, simulation experiments and engineering application of bearing fault diagnosis demonstrate the effectiveness and feasibility of the proposed method.

  12. The value of a new microculture method for diagnosis of visceral leishmaniasis by using bone marrow and peripheral blood.

    Science.gov (United States)

    Allahverdiyev, Adil M; Bagirova, Malahat; Uzun, Soner; Alabaz, Derya; Aksaray, Necmi; Kocabas, Emine; Koksal, Fatih

    2005-08-01

    We have demonstrated that the microculture method (MCM) enables the diagnosis of visceral leishmaniasis (VL) with samples from both the bone marrow (BM) and peripheral blood (PB). The MCM is superior to the traditional culture method (TCM) as determined by its higher sensitivity in the detection of promastigotes and the more rapid time for emergence of promastigotes. The sensitivity of MCM (100% in BMs and 77.8-100% in PB) was considerably higher than that of the TCM (37.5-100% in BMs and 0-100% in PB) according to decreasing parasite density (P < 0.05). The concentration of parasites in buffy coats has increased the sensitivity of both methods, especially that of the MCM. Detection of promastigotes by MCM requires lower amounts of culture media (25-50 microL) and shorter incubation periods (2-7 days) than TCM (2.5-3.5 mL and 15-35 days, respectively). MCM was found to be valuable with the advantages of simplicity and sensitivity, in addition to being cost-effective in the routine diagnosis for VL in Adana Turkey.

  13. A method for diagnosis of plant environmental stresses by gene expression profiling using a cDNA macroarray

    International Nuclear Information System (INIS)

    Tamaoki, Masanori; Matsuyama, Takashi; Nakajima, Nobuyoshi; Aono, Mitsuko; Kubo, Akihiro; Saji, Hikaru

    2004-01-01

    Plants in the field are subjected to numerous environmental stresses. Lengthy continuation of such environmental stresses or a rapid increase in their intensity is harmful to vegetation. Assessments of the phytotoxicity of various stresses have been performed in many countries, although they have largely been based on estimates of leaf injury. We developed a novel method of detecting plant stresses that is more sensitive and specific than those previously available. This method is based on the detection of mRNA expression changes in 205 ozone-responsive Arabidopsis expressed sequence tags (ESTs) by cDNA macroarray analysis. By using this method, we illustrated shifts in gene expression in response to stressors such as drought, salinity, UV-B, low temperature, high temperature, and acid rain, as distinct from those in response to ozone. We also made a mini-scale macroarray with 12 ESTs for diagnosis of the above environmental stresses in plants. These results illustrate the potential of our cDNA macroarray for diagnosis of various stresses in plants

  14. High dimension feature extraction based visualized SOM fault diagnosis method and its application in p-xylene oxidation process☆

    Institute of Scientific and Technical Information of China (English)

    Ying Tian; Wenli Du; Feng Qian

    2015-01-01

    Purified terephthalic acid (PTA) is an important chemical raw material. P-xylene (PX) is transformed to terephthalic acid (TA) through oxidation process and TA is refined to produce PTA. The PX oxidation reaction is a complex process involving three-phase reaction of gas, liquid and solid. To monitor the process and to im-prove the product quality, as wel as to visualize the fault type clearly, a fault diagnosis method based on self-organizing map (SOM) and high dimensional feature extraction method, local tangent space alignment (LTSA), is proposed. In this method, LTSA can reduce the dimension and keep the topology information simultaneously, and SOM distinguishes various states on the output map. Monitoring results of PX oxidation reaction process in-dicate that the LTSA–SOM can wel detect and visualize the fault type.

  15. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis

    DEFF Research Database (Denmark)

    Gundersen, H J; Bendtsen, T F; Korbo, L

    1988-01-01

    Stereology is a set of simple and efficient methods for quantitation of three-dimensional microscopic structures which is specifically tuned to provide reliable data from sections. Within the last few years, a number of new methods has been developed which are of special interest to pathologists...... are invariably simple and easy....

  16. Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis

    DEFF Research Database (Denmark)

    Cajanus, Antti; Hall, Anette; Koikkalainen, Juha

    2018-01-01

    genetic status in the differentiation sensitivity. Methods: The MRI scans of 50 patients with bvFTD (17 C9ORF72 expansion carriers) were analyzed using 6 quantification methods as follows: voxel-based morphometry (VBM), tensor-based morphometry, volumetry (VOL), manifold learning, grading, and white...

  17. Application of a PCR method for the diagnosis of ulcerative enteritis: preliminary results

    Directory of Open Access Journals (Sweden)

    Fabrizio Agnoletti

    2010-01-01

    Full Text Available Ulcerative enteritis or “quail disease” is an acute clostridial infection of young birds reported in many avian species, chicken and turkey included. Clostridium colinum is the causative agent of ulcerative enteritis and because of the difficulties bound to the isolation and identification of this bacterium by means of classic bacteriological techniques, its detection appears very hard and the prevalence of this disease could be underestimated. To investigate the diffusion of C. colinum in enteric disease of birds, a recently developed PCR protocol was applied to 42 cultural broths previously inoculated with organs and intestinal samples collected from diseased subjects. PCR-positive broths were cultivated to attempt the isolation of C. colinum. Samples collected from positive birds were subjected to histological examinations. 4 birds (3 broilers chickens and 1 pigeon resulted PCR-positive and, in one case, C. colinum was isolated. Gross and histological lesions of positive birds were compatible with those described in other ulcerative enteritis outbreaks. These preliminary results demonstrates that C. colinum is sporadically implicated in enteric diseases of broiler chickens (14.2%. In addition, the PCR assay proved to be an useful and reliable instrument to support the diagnosis of ulcerative enteritis and to facilitate the isolation of C. colinum.

  18. Iodination of monoclonal antibodies for diagnosis and radiotherapy using a convenient one vial method

    International Nuclear Information System (INIS)

    Haisma, H.J.; Hilgers, J.; Zurawski, V.R. Jr.

    1986-01-01

    We have developed a convenient system that can be used to iodinate monoclonal antibodies for diagnosis or therapy. A vial, previously coated with 1,3,4,6-tetrachloro-3a, 6a-diphenyl glycouril (iodogen), is used as a reaction vessel. Iodination and separation of bound and free iodide, using AG1-X8 ion exchange resin, are both accomplished in this vial. We found 90 +/- 4% of the iodide which was added was incorporated, respectively, into each of four different monoclonal antibodies evaluated. Approximately 90% of labeled antibody was recovered in each case. The monoclonal antibody OC125 was labeled to specific activities up to 25 mCi/mg. Immunoreactivities of 82 +/- 2% using 125 I and 66 +/- 5% using 131 I were achieved. As the radioiodination is done in one sealed vial and takes less than 15 min, this procedure is safe and can be performed in any nuclear medicine laboratory. The final product, which is sterile and apyrogenic, is suitable for diagnostic and radiotherapeutic applications

  19. Fault Diagnosis of Car Engine by Using a Novel GA-Based Extension Recognition Method

    Directory of Open Access Journals (Sweden)

    Meng-Hui Wang

    2014-01-01

    Full Text Available Due to the passenger’s security, the recognized hidden faults in car engines are the most important work for a maintenance engineer, so they can regulate the engines to be safe and improve the reliability of automobile systems. In this paper, we will present a novel fault recognition method based on the genetic algorithm (GA and the extension theory and also apply this method to the fault recognition of a practical car engine. The proposed recognition method has been tested on the Nissan Cefiro 2.0 engine and has also been compared to other traditional classification methods. Experimental results are of great effect regarding the hidden fault recognition of car engines, and the proposed method can also be applied to other industrial apparatus.

  20. A Novel Characteristic Frequency Bands Extraction Method for Automatic Bearing Fault Diagnosis Based on Hilbert Huang Transform

    Directory of Open Access Journals (Sweden)

    Xiao Yu

    2015-11-01

    Full Text Available Because roller element bearings (REBs failures cause unexpected machinery breakdowns, their fault diagnosis has attracted considerable research attention. Established fault feature extraction methods focus on statistical characteristics of the vibration signal, which is an approach that loses sight of the continuous waveform features. Considering this weakness, this article proposes a novel feature extraction method for frequency bands, named Window Marginal Spectrum Clustering (WMSC to select salient features from the marginal spectrum of vibration signals by Hilbert–Huang Transform (HHT. In WMSC, a sliding window is used to divide an entire HHT marginal spectrum (HMS into window spectrums, following which Rand Index (RI criterion of clustering method is used to evaluate each window. The windows returning higher RI values are selected to construct characteristic frequency bands (CFBs. Next, a hybrid REBs fault diagnosis is constructed, termed by its elements, HHT-WMSC-SVM (support vector machines. The effectiveness of HHT-WMSC-SVM is validated by running series of experiments on REBs defect datasets from the Bearing Data Center of Case Western Reserve University (CWRU. The said test results evidence three major advantages of the novel method. First, the fault classification accuracy of the HHT-WMSC-SVM model is higher than that of HHT-SVM and ST-SVM, which is a method that combines statistical characteristics with SVM. Second, with Gauss white noise added to the original REBs defect dataset, the HHT-WMSC-SVM model maintains high classification accuracy, while the classification accuracy of ST-SVM and HHT-SVM models are significantly reduced. Third, fault classification accuracy by HHT-WMSC-SVM can exceed 95% under a Pmin range of 500–800 and a m range of 50–300 for REBs defect dataset, adding Gauss white noise at Signal Noise Ratio (SNR = 5. Experimental results indicate that the proposed WMSC method yields a high REBs fault

  1. Constitutive Modelling in Geomechanics Introduction

    CERN Document Server

    Puzrin, Alexander M

    2012-01-01

    The purpose of this book is to bridge the gap between the traditional Geomechanics and Numerical Geotechnical Modelling with applications in science and practice. Geomechanics is rarely taught within the rigorous context of Continuum Mechanics and Thermodynamics, while when it comes to Numerical Modelling, commercially available finite elements or finite differences software utilize constitutive relationships within the rigorous framework. As a result, young scientists and engineers have to learn the challenging subject of constitutive modelling from a program manual and often end up with using unrealistic models which violate the Laws of Thermodynamics.  The book is introductory, by no means does it claim any completeness and state of the art in such a dynamically developing field as numerical and constitutive modelling of soils. The author gives basic understanding of conventional continuum mechanics approaches to constitutive modelling, which can serve as a foundation for exploring more advanced theories....

  2. The Constitution's Prescription for Freedom.

    Science.gov (United States)

    Peach, Lucinda

    1986-01-01

    Examines how the framers of the Constitution came to choose our system of government, how that system was designed to function, and how the separation of powers has served to maintain our democracy despite attempts to violate it. (JDH)

  3. Jonathan's Constitutional Conference in Nigeria

    African Journals Online (AJOL)

    ian

    2013-10-01

    Oct 1, 2013 ... Adeniyi S. Basiru is an independent researcher and a PhD candidate ... constitution-making are fundamentally the exclusive reserve of the elites, ..... agenda must be situated against the background of events that heralded his.

  4. THE EMERGING INTERNATIONAL CONSTITUTIONAL ORDER ...

    African Journals Online (AJOL)

    Dr Tanya du Plessis

    CFI) affirmed ... primarily include the value system of the international legal order, meaning norms of ... the existence of such a traditional constitutional demos. Europe's ..... between the African Development Bank (BAD) and one of its employees,.

  5. Constitutional Verbosity and Social Trust

    DEFF Research Database (Denmark)

    Bjørnskov, Christian; Voigt, Stefan

    2014-01-01

    A common argument in the trust literature is that high-trust cultures allow efficient commercial contracts to be shorter, covering fewer contingencies. We take this idea to the topic of social contracts. Specifically, we ask whether social trust affects the length and detail of constitutions. Cross......-country estimates suggest that national trust levels are indeed robustly and negatively associated with the length of countries’ constitutions....

  6. Constitutional orders in multinational firms

    DEFF Research Database (Denmark)

    Hull Kristensen, Peer; Morgan, Glenn

    Multinationals are faced with the problem of how to coordinate different actors and stop `fiefdoms' emerging that inhibits the achievement of transnational cooperation? We identify this as a problem of `constitutional ordering' in the firm. Drawing on Varieties of Capitalism approaches, we explore...... how multinationals from different contexts seek to create constitutional orders. We argue that the models which exist appear to be destructive of coordination. We explore the implications for MNCs....

  7. Application of the ecosystem diagnosis and treatment method to the Grande Ronde Model Watershed project. Final report

    International Nuclear Information System (INIS)

    Mobrand, L.; Lestelle, L.

    1997-01-01

    In the spring of 1994 a technical planning support project was initiated by the Grande Ronde Model Watershed Board of Directors (Board) with funding from the Bonneville Power Administration. The project was motivated by a need for a science based method for prioritizing restoration actions in the basin that would promote effectiveness and accountability. In this section the authors recall the premises for the project. The authors also present a set of recommendations for implementing a watershed planning process that incorporates a science-based framework to help guide decision making. This process is intended to assist the Grande Ronde Model Watershed Board in its effort to plan and implement watershed improvement measures. The process would also assist the Board in coordinating its efforts with other entities in the region. The planning process is based on an approach for developing an ecosystem management strategy referred to as the Ecosystem Diagnosis and Treatment (EDT) method (Lichatowich et al. 1995, Lestelle et al. 1996). The process consists of an on-going planning cycle. Included in this cycle is an assessment of the ability of the watershed to support and sustain natural resources and other economic and societal values. This step in the process, which the authors refer to as the diagnosis, helps guide the development of actions (also referred to as treatments) aimed at improving the conditions of the watershed to achieve long-term objectives. The planning cycle calls for routinely reviewing and updating, as necessary, the basis for the diagnosis and other analyses used by the Board in adopting actions for implementation. The recommendations offered here address this critical need to habitually update the information used in setting priorities for action

  8. Application of the Ecosystem Diagnosis and Treatment Method to the Grande Ronde Model Watershed project : Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    Mobrand, Lars Erik; Lestelle, Lawrence C.

    1997-01-01

    In the spring of 1994 a technical planning support project was initiated by the Grande Ronde Model Watershed Board of Directors (Board) with funding from the Bonneville Power Administration. The project was motivated by a need for a science based method for prioritizing restoration actions in the basin that would promote effectiveness and accountability. In this section the authors recall the premises for the project. The authors also present a set of recommendations for implementing a watershed planning process that incorporates a science-based framework to help guide decision making. This process is intended to assist the Grande Ronde Model Watershed Board in its effort to plan and implement watershed improvement measures. The process would also assist the Board in coordinating its efforts with other entities in the region. The planning process is based on an approach for developing an ecosystem management strategy referred to as the Ecosystem Diagnosis and Treatment (EDT) method (Lichatowich et al. 1995, Lestelle et al. 1996). The process consists of an on-going planning cycle. Included in this cycle is an assessment of the ability of the watershed to support and sustain natural resources and other economic and societal values. This step in the process, which the authors refer to as the diagnosis, helps guide the development of actions (also referred to as treatments) aimed at improving the conditions of the watershed to achieve long-term objectives. The planning cycle calls for routinely reviewing and updating, as necessary, the basis for the diagnosis and other analyses used by the Board in adopting actions for implementation. The recommendations offered here address this critical need to habitually update the information used in setting priorities for action.

  9. Phenol-ammonium sulfate microscopy method for diagnosis of pulmonary tuberculosis

    Directory of Open Access Journals (Sweden)

    Ritu Singhal

    2013-01-01

    Conclusion: Sputum microscopy with PhAS solution is a safe, reliable and inexpensive alternative for direct microscopy. This method can be conveniently applied for usage in microscopy centers with limited bio-safety facilities.

  10. Efficacy of parasitological diagnosis methods in wild animals kept in captivity

    OpenAIRE

    Carvalho, Aline Feola; Barnabe, Anderson Sena; Federsoni, Igor Popovic; Ferraz, Renato Ribeiro Nogueira; Marco, Rogerio Milton De; Garcia, Isabel Priscilla

    2018-01-01

    ABSTRACT: Parasitic diseases are common in wild animals kept in captivity, and the research of these parasites is a tool used in wildlife management actions. Once the method most used in the practice of veterinary laboratories is the direct examination, it was considered appropriate to report the parasitism in captivity wildlife comparing this technique with modified methods of Hoffman, Pons and Janer (HPJ) and Willis. Fresh feces were surveyed in eleven precincts with specimens of the class ...

  11. Dobutamine stress magnetic resonance imaging: a valuable method in the noninvasive diagnosis of ischemic heart disease.

    Science.gov (United States)

    van Dijkman, Paul R M; Kuijpers, Dirkjan A; Blom, Bernadette M; van Herpen, Gerard

    2002-01-01

    We assessed the clinical applicability of dobutamine stress magnetic resonance imaging (DS-MRI) for the detection of myocardial ischemia and myocardial viability. One hundred patients with suspected coronary artery disease and inconclusive exercise electrocardiography or significant repolarization abnormalities on the resting ECG underwent breath hold DS-MRI (1 Tesla), 4 days after cessation of anti-ischemic medication. Three left ventricular short axis planes were imaged at increasing doses of dobutamine. Recovery of wall thickening in a previously diminished or non contracting segment at low dose dobutamine was considered proof of viability. Development of hypo-, a- or dyskinesia at higher doses of dobutamine was taken to indicate ischemia. If the DS-MRI test was positive for ischemia, coronary angiography was performed. If indicated, this was followed by revascularization. If DS-MRI did not demonstrate ischemia, neither angiography nor revascularization were carried out. Ninety five DS-MRI investigations were available for diagnosis. Forty two patients had DS-MRI scans positive for ischemia and subsequently coronary angiography assessment of the clinical applicability of DS-MRI for the detection of myocardial ischemia was performed. One patient was false-positive. All 53 patients with non-ischemic DS-MRI scans had follow-up for 11-23 months (mean 17 months). One patient died suddenly 2 weeks after the MRI-test. The other 52 patients did not experience any coronary event nor sudden cardiac death. The predictive value of a positive (for ischemia) DS-MRI test is 98% and the predictive value of a negative DS-MRI test is also 98%.

  12. Utility of PCR, Culture, and Antigen Detection Methods for Diagnosis of Legionellosis.

    Science.gov (United States)

    Chen, Derrick J; Procop, Gary W; Vogel, Sherilynn; Yen-Lieberman, Belinda; Richter, Sandra S

    2015-11-01

    The goal of this retrospective study was to evaluate the performance of different diagnostic tests for Legionnaires' disease in a clinical setting where Legionella pneumophila PCR had been introduced. Electronic medical records at the Cleveland Clinic were searched for Legionella urinary antigen (UAG), culture, and PCR tests ordered from March 2010 through December 2013. For cases where two or more test methods were performed and at least one was positive, the medical record was reviewed for relevant clinical and epidemiologic factors. Excluding repeat testing on a given patient, 19,912 tests were ordered (12,569 UAG, 3,747 cultures, and 3,596 PCR) with 378 positive results. The positivity rate for each method was 0.4% for culture, 0.8% for PCR, and 2.7% for UAG. For 37 patients, at least two test methods were performed with at least one positive result: 10 (27%) cases were positive by all three methods, 16 (43%) were positive by two methods, and 11 (30%) were positive by one method only. For the 32 patients with medical records available, clinical presentation was consistent with proven or probable Legionella infection in 84% of the cases. For those cases, the sensitivities of culture, PCR, and UAG were 50%, 92%, and 96%, respectively. The specificities were 100% for culture and 99.9% for PCR and UAG. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  13. Right Product, Wrong Packaging: Not 'Constitution', but 'Constitutional Charter'

    Directory of Open Access Journals (Sweden)

    John Law

    2007-05-01

    Full Text Available The article seeks to locate the principal cause of Europe’s prevailing ratification crisis in the inappropriate title arrived at in the European Convention, Treaty Establishing a Constitution for Europe. This over-ambitious styling led the media to characterise the text as simply an ‘EU Constitution’. Yet, the text was not a Constitution as we traditionally understand the term, i.e. the founding document of a State: scholars are agreed that the EU is not, and will not become upon ratification, a State.In terms of substance, whilst the text certainly strengthened some emerging constitutional aspects, it was not a major departure from the status quo like the Single European Act and Treaty on European Union had been; and it remained technically a treaty like all its predecessors. Arguably, therefore, it did not require referenda to ratify. However, confusion over the scale and importance of what was proposed, stemming from ambiguity in the title, pushed politicians down this unfortunate path.The article identifies a high level of consensus among commentators as to the true nature of the text: most are happy designating it a treaty (noun with constitutional (adjective aspects. The early proposed title Constitutional Treaty for Europe was arguably, therefore, the correct one; but it is now too late to choose this option, as the terms Constitution and Constitutional Treaty have already been muddled in debate. A more distinctive change is required. One idea could be to follow the principle employed elsewhere in the text of codifying the generally accepted but presently unwritten legal concepts of the European Court of Justice, as was done for example for ‘primacy’ and ‘direct effect’. The Court has characterised the EU treaties as a ‘constitutional charter’ for over twenty years now, and on this basis a modified title could read Treaty Establishing a Constitutional Charter for Europe. Importantly, the term ‘charter’ is recognised

  14. Study on vibration characteristics and fault diagnosis method of oil-immersed flat wave reactor in Arctic area converter station

    Science.gov (United States)

    Lai, Wenqing; Wang, Yuandong; Li, Wenpeng; Sun, Guang; Qu, Guomin; Cui, Shigang; Li, Mengke; Wang, Yongqiang

    2017-10-01

    Based on long term vibration monitoring of the No.2 oil-immersed fat wave reactor in the ±500kV converter station in East Mongolia, the vibration signals in normal state and in core loose fault state were saved. Through the time-frequency analysis of the signals, the vibration characteristics of the core loose fault were obtained, and a fault diagnosis method based on the dual tree complex wavelet (DT-CWT) and support vector machine (SVM) was proposed. The vibration signals were analyzed by DT-CWT, and the energy entropy of the vibration signals were taken as the feature vector; the support vector machine was used to train and test the feature vector, and the accurate identification of the core loose fault of the flat wave reactor was realized. Through the identification of many groups of normal and core loose fault state vibration signals, the diagnostic accuracy of the result reached 97.36%. The effectiveness and accuracy of the method in the fault diagnosis of the flat wave reactor core is verified.

  15. On-line and real-time diagnosis method for proton membrane fuel cell (PEMFC) stack by the superposition principle

    Science.gov (United States)

    Lee, Young-Hyun; Kim, Jonghyeon; Yoo, Seungyeol

    2016-09-01

    The critical cell voltage drop in a stack can be followed by stack defect. A method of detecting defective cell is the cell voltage monitoring. The other methods are based on the nonlinear frequency response. In this paper, the superposition principle for the diagnosis of PEMFC stack is introduced. If critical cell voltage drops exist, the stack behaves as a nonlinear system. This nonlinearity can explicitly appear in the ohmic overpotential region of a voltage-current curve. To detect the critical cell voltage drop, a stack is excited by two input direct test-currents which have smaller amplitude than an operating stack current and have an equal distance value from the operating current. If the difference between one voltage excited by a test current and the voltage excited by a load current is not equal to the difference between the other voltage response and the voltage excited by the load current, the stack system acts as a nonlinear system. This means that there is a critical cell voltage drop. The deviation from the value zero of the difference reflects the grade of the system nonlinearity. A simulation model for the stack diagnosis is developed based on the SPP, and experimentally validated.

  16. Comparison of viral RNA electrophoresis and indirect ELISA methods in the diagnosis of human rotavirus infection

    Energy Technology Data Exchange (ETDEWEB)

    Avendano, L F; Dubinovsky, S; James, Jr, H D

    1984-01-01

    A total of 177 stool samples from Chilean diarrhea patients under two years of age were tested for rotavirus by two methods - the indirect enzyme-linked immunosorbent assay (indirect ELISA) and viral RNA electrophoresis in agarose gels (v RNA EPH). Fifty of the specimens came from patients with acute diarrhea and 127 came from patients with protracted diarrhea. The indirect ELISA testing was performed at the National Institutes of Health in the United States: the electrophoretic testing was carried out in Santiago, Chile by the authors. The electrophoretic method detected rotavirus in 36% of the acute samples and 25% of the samples from protracted cases, while the indirect ELISA method detected rotavirus in higher percentages of samples - 46% and 38%, respectively. These results support the conclusion that v RNA EPH is a less sensitive method for detecting rotavirus than the indirect ELISA. Nevertheless, the former method's high specificity, ease of application, and low cost make it a worthwhile alternative to indirect ELISA. Thus, considering the important role played by rotavirus in infant diarrhea and the need for a diagnostic technique that can be incorporated into the routines of medical center laboratories in developing countries, there is good reason to conclude that v RNA EPH is a useful tool for studying rotavirus diarrhea. 18 refs, 3 tabs. Also published in the Bol. Oficina Sanit. Panam. (1984) v. 97(1), p. 1-7 (In Spanish).

  17. Comparison of viral RNA electrophoresis and indirect ELISA methods in the diagnosis of human rotavirus infection

    International Nuclear Information System (INIS)

    Avendano, L.F.; Dubinovsky, S.

    1984-01-01

    A total of 177 stool samples from Chilean diarrhea patients under two years of age were tested for rotavirus by two methods - the indirect enzyme-linked immunosorbent assay (indirect ELISA) and viral RNA electrophoresis in agarose gels (v RNA EPH). Fifty of the specimens came from patients with acute diarrhea and 127 came from patients with protracted diarrhea. The indirect ELISA testing was performed at the National Institutes of Health in the United States: the electrophoretic testing was carried out in Santiago, Chile by the authors. The electrophoretic method detected rotavirus in 36% of the acute samples and 25% of the samples from protracted cases, while the indirect ELISA method detected rotavirus in higher percentages of samples - 46% and 38%, respectively. These results support the conclusion that v RNA EPH is a less sensitive method for detecting rotavirus than the indirect ELISA. Nevertheless, the former method's high specificity, ease of application, and low cost make it a worthwhile alternative to indirect ELISA. Thus, considering the important role played by rotavirus in infant diarrhea and the need for a diagnostic technique that can be incorporated into the routines of medical center laboratories in developing countries, there is good reason to conclude that v RNA EPH is a useful tool for studying rotavirus diarrhea. (author)

  18. Sensitivity assessment of direct method for diagnosis of Trichomonas vaginalis in comparison with Dorset Culture media

    Directory of Open Access Journals (Sweden)

    ebrahim badparva

    2010-04-01

    Full Text Available Trichomonas vaginalis is a flagellate protozoan that lives in the genital tract and causes trichomoniasis in women. About 200 million people all over the world are infected with T. vaginalis. There are various methods with different sensitivity and specificity for detection of this parasite, that one of them is direct smear of vaginal secretions which is simpler, rapid and cheaper than other diagnostic methods. Materials and Methods: Demographic data was gathered by a questionnaire which contained different variables. Vaginal secretions samples were taken by spicolum and two swaps that maintained in glucose solution in separate tubes from 160 women referred to health centers of Khorramabad. One of the vaginal samples was examined by direct smear in saline solution and the other was cultured in Dorse medium. Results: Of 160 women suspected of trichomoniasis, 11.8% and 18.75% were positive by direct smear and culture respectively. The sensitivity of the direct method was 63.3%. Our findings indicated that 30% of the infected women belonged to the 31 – 35 age group, which had the most relative frequency of positive cases. Most of the patients (43% were illiterate or had elementary educational level. Conclussion: The sensivity of direct method is 63% in compare to culture ( as a Gold standard , which is ralatively low . Although the efficacy of this test could be imporved by shortening the elapsed time between sampling and examination , use of skilled microscopists , and different samples , but we recommend that more sensitive methods such as culture and PCR should be used .

  19. Feasibility study of structured diagnosis methods for functional dyspepsia in Korean medicine clinics

    Directory of Open Access Journals (Sweden)

    Jeong Hwan Park

    2017-12-01

    Full Text Available Background: Functional dyspepsia (FD is the seventh most common disease encountered in Korean medicine (KM clinics. Despite the large number of FD patients visiting KM clinics, the accumulated medical records have no utility in evidence development, due to being unstructured. This study aimed to construct a standard operating procedure (SOP with appropriate structured diagnostic methods for FD, and assess the feasibility for use in KM clinics. Methods: Two rounds of professional surveys were conducted by 10 Korean internal medicine professors to select the representative diagnostic methods. A feasibility study was conducted to evaluate compliance and time required for using the structured diagnostic methods by three specialists in two hospitals. Results: As per the results of the professional survey, five questionnaires and one basic diagnostic method were selected. An SOP was constructed based on the survey results, and a feasibility study showed that the SOP compliance score (out of 5 was 3.45 among the subjects, and 3.25 among the practitioners. The SOP was acceptable and was not deemed difficult to execute. The total execution time was 136.5 minutes, out of which the gastric emptying test time was 129 minutes. Conclusion: This feasibility study of the SOP with structured diagnostic methods for FD confirmed it was adequate for use in KM clinics. It is expected that these study findings will be helpful to clinicians who wish to conduct observational studies as well as to generate quantitative medical records to facilitate Big Data research. Keywords: Big Data, Dyspepsia, Korean medicine, Feasibility studies, Observational study

  20. The Diagnosis of Internal Leakage of Control Valve Based on the Grey Correlation Analysis Method

    Directory of Open Access Journals (Sweden)

    Zheng DING

    2014-07-01

    Full Text Available The valve plays an important part in the industrial automation system. Whether it operates normally or not relates with the quality of the products directly while its faults are relatively common because of bad working conditions. And the internal leakage is one of the common faults. Consequently, this paper sets up the experimental platform to make the valve in different working condition and collect relevant data online. Then, diagnose the internal leakage of the valve by using the grey correlation analysis method. The results show that this method can not only diagnose the internal leakage of valve accurately, but also distinguish fault degree quantitatively.

  1. Automated method to compute Evans index for diagnosis of idiopathic normal pressure hydrocephalus on brain CT images

    Science.gov (United States)

    Takahashi, Noriyuki; Kinoshita, Toshibumi; Ohmura, Tomomi; Matsuyama, Eri; Toyoshima, Hideto

    2017-03-01

    The early diagnosis of idiopathic normal pressure hydrocephalus (iNPH) considered as a treatable dementia is important. The iNPH causes enlargement of lateral ventricles (LVs). The degree of the enlargement of the LVs on CT or MR images is evaluated by using a diagnostic imaging criterion, Evans index. Evans index is defined as the ratio of the maximal width of frontal horns (FH) of the LVs to the maximal width of the inner skull (IS). Evans index is the most commonly used parameter for the evaluation of ventricular enlargement. However, manual measurement of Evans index is a time-consuming process. In this study, we present an automated method to compute Evans index on brain CT images. The algorithm of the method consisted of five major steps: standardization of CT data to an atlas, extraction of FH and IS regions, the search for the outmost points of bilateral FH regions, determination of the maximal widths of both the FH and the IS, and calculation of Evans index. The standardization to the atlas was performed by using linear affine transformation and non-linear wrapping techniques. The FH regions were segmented by using a three dimensional region growing technique. This scheme was applied to CT scans from 44 subjects, including 13 iNPH patients. The average difference in Evans index between the proposed method and manual measurement was 0.01 (1.6%), and the correlation coefficient of these data for the Evans index was 0.98. Therefore, this computerized method may have the potential to accurately compute Evans index for the diagnosis of iNPH on CT images.

  2. Early Diagnosis of Breas Cancer Dissemination by Tumor Markers Follow-Up and Method of Prediction

    Czech Academy of Sciences Publication Activity Database

    Nekulová, M.; Šimíčková, M.; Pecen, Ladislav; Eben, Kryštof; Vermousek, I.; Stratil, P.; Černoch, M.; Lang, B.

    1994-01-01

    Roč. 41, č. 2 (1994), s. 113-118 ISSN 0028-2685 R&D Projects: GA AV ČR IAA230106 Keywords : breast cancer * progression * CEA * CA 15-3 * MCA * TPA * mathematical method of prediction Impact factor: 0.354, year: 1994

  3. A quantitative and qualitative evaluation of trainee opinions of four methods of personality disorder diagnosis.

    Science.gov (United States)

    Nelson, Sharon M; Huprich, Steven K; Shankar, Sneha; Sohnleitner, Aimee; Paggeot, Amy V

    2017-07-01

    Four methods of how to assess and diagnose personality disorders have received much attention within the literature: the Shedler-Westen Assessment Procedure (Shedler & Westen, 1998), the DSM-5 Section III Personality Disorders section (APA, 2011), the DSM-5 Section III trait model (APA, 2013), and the Psychodynamic Diagnostic Manual (PDM; PDM Task Force, 2006) descriptions of 15 personality disorders. Given that much of the debate has been driven by clinician concerns, it is important to consider clinical utility when evaluating the usefulness of each method. The present study compares the 4 models on ratings of several dimensions of clinical utility provided by 329 graduate student clinicians and psychology interns from across the United States. Findings suggest that participants rated the DSM-5 trait model significantly higher in most clinical utility domains. Additionally, qualitative analyses of the open-ended responses provided by participants indicated that each method had strengths and weaknesses. Most notably, participants commented positively on the PDM's level of comprehensiveness and appreciated the SWAP-II's inclusion of a health category, despite the ease of use not being as highly rated for these methods. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  4. [Diagnosis of insulin resistance by indirect methods in obese school children].

    Science.gov (United States)

    Angulo, Nerkis; de Szarvas, Sobeida Barbella; Mathison, Yaira; Hadad, Erika; González, Dora; Hernández, Ana; Guevara, Harold

    2013-06-01

    Obesity leads to a deterioration of glucose tolerance and the action of insulin. The purpose of this study was to determine insulin resistance (IR) by indirect methods, and its correlation with clinical, anthropometric and biochemical variables in obese normoglycemic school children. This was a descriptive-correlational study of 72 school prepubescent children, who attended the ambulatory "El Concejo" of the University of Carabobo (UC) and at the Gastroenterology and Pediatric Nutrition service of the city hospital "Enrique Tejera" (CHET), in Valencia, Venezuela, between January-April 2011. exogenous obesity. We assessed personal and family history, presence of Acanthosis Nigricans and nutritional and biochemical status. We found a higher percentage of IR, through the use of the QUICKI method (66.7%), followed by the HOMA (55.6%) and basal insulin (45.9%). The mean (chi) indexes of body mass and waist circumference were significantly greater (p method detected significant differences (p methods. In conclusion, the evaluated techniques, QUICKI, HOMA and basal insulin indexes, were most effective for detecting the IR.

  5. Entropy Based Test Point Evaluation and Selection Method for Analog Circuit Fault Diagnosis

    Directory of Open Access Journals (Sweden)

    Yuan Gao

    2014-01-01

    Full Text Available By simplifying tolerance problem and treating faulty voltages on different test points as independent variables, integer-coded table technique is proposed to simplify the test point selection process. Usually, simplifying tolerance problem may induce a wrong solution while the independence assumption will result in over conservative result. To address these problems, the tolerance problem is thoroughly considered in this paper, and dependency relationship between different test points is considered at the same time. A heuristic graph search method is proposed to facilitate the test point selection process. First, the information theoretic concept of entropy is used to evaluate the optimality of test point. The entropy is calculated by using the ambiguous sets and faulty voltage distribution, determined by component tolerance. Second, the selected optimal test point is used to expand current graph node by using dependence relationship between the test point and graph node. Simulated results indicate that the proposed method more accurately finds the optimal set of test points than other methods; therefore, it is a good solution to minimize the size of the test point set. To simplify and clarify the proposed method, only catastrophic and some specific parametric faults are discussed in this paper.

  6. Diagnosis of austenitic steel valves with the magneto-optical method

    Czech Academy of Sciences Publication Activity Database

    Novotný, P.; Macháč, P.; Kučera, M.; Nitsch, Karel; Skrbek, B.

    2007-01-01

    Roč. 40, - (2007), s. 203-207 ISSN 0963-8695 Institutional research plan: CEZ:AV0Z10100521 Keywords : austenic steel * mangetooptical method * LPG garnet films Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.131, year: 2007

  7. Development and Validation of a GC-FID Method for Diagnosis of Methylmalonic Acidemia

    Directory of Open Access Journals (Sweden)

    Fatemeh Keyfi

    2016-05-01

    Full Text Available Background: Urinary organic acids are water-soluble intermediates and end products of the metabolism of amino acids, carbohydrates, lipids, and a number of other metabolic processes. In the hereditary diseases known as organic acidurias, an enzyme or co-factor defect in a metabolic pathway leads to the accumulation and increased excretion of one or more of these acidic metabolites. Gas chromatography is the most commonly-used technology to separate and identify these metabolites. In this report the analytical conditions for the determination of methylmalonic acid using a gas chromatography/flame ionization detector (GC-FID are studied with the aim to establish a method to analyze organic acids in human urine. Methods: Studies included the GC-FID method development, the conditions of the derivatization (trimethylsilylation reaction, and the stability of the methylmalonic acid standard solution and trimethylsilyl derivatives during storage. Also, a systematic comparison between GC-FID and gas chromatography/mass spectrometry (GC-MS was performed. Results: The highest resolution and sensitivity were obtained at 60 oC with a 30 min reaction time. Standard solutions and derivatized samples were stable for 7 days at 4-8 oC. Relative standard deviations of within-day and day-to-day assay results were less than 5%. Methylmalonic acid was detected in thirty human urine samples by the proposed GC-FID, and the results were compared with gold standard technique GC-MS. The correlation coefficient between GC-MS and GC-FID was obtained with R2= 0.997. Conclusions: The developed method was applied to the quantitative analysis of methylmalonic acid in urine from hospitalized children with methylmalonic acidemia. With this method we aim to support pediatric clinics in Iran and assist in clinical diagnostics.

  8. Constitutional compatibility of energy systems

    International Nuclear Information System (INIS)

    Rossnagel, A.

    1983-01-01

    The paper starts from the results of the Enquiry Commission on 'Future Nuclear Energy Policy' of the 8th Federal German Parliament outlining technically feasible energy futures in four 'pathways'. For the purpose of the project, which was to establish the comparative advantages and disadvantages of different energy systems, these four scenarios were reduced to two alternatives: cases K (= nuclear energy) and S (= solar energy). The question to Ge put is: Which changes within our legal system will be ushered in by certain technological developments and how do these changes relate to the legal condition intended so far. Proceeding in this manner will not lead to the result of a nuclear energy system or a solar energy system being in conformity or in contradiction with the constitutional law, but will provide a catalogue of implications orientated to the aims of legal standards: a person deciding in favour of a nuclear energy system or a solar energy system supports this or that development of constitutional policy, and a person purishing this or that aim of legal policy should be consistent and decide in favour of this or that energy system. The investigation of constitutional compatibility leads to the question what effects different energy systems will have on the forms of political intercourse laid down in the constitutional law, which are orientated to models of a liberal constitutional tradition of citizens. (orig./HSCH) [de

  9. Automation Diagnosis of Skin Disease in Humans using Dempster-Shafer Method

    Science.gov (United States)

    Khairina, Dyna Marisa; Hatta, Heliza Rahmania; Rustam; Maharani, Septya

    2018-02-01

    Skin disease is an infectious disease that is common in people of all ages. Disorders of the skin often occur because there are factors, among others, are climate, environment, shelter, unhealthy living habits, allergies and others. Skin diseases in Indonesia are mostly caused by bacterial, fungal, parasitic, and allergies. The objective of the research is to diagnose skin diseases in humans by using the method of making decision tree then performing the search by forward chaining and calculating the probability value of Dempster-Shafer method. The results of research in the form of an automated system that can resemble an expert in diagnosing skin disease accurately and can help in overcoming the problem of skin diseases.

  10. Use of aspiration method for collecting brain samples for rabies diagnosis in small wild animals.

    Science.gov (United States)

    Iamamoto, K; Quadros, J; Queiroz, L H

    2011-02-01

    In developing countries such as Brazil, where canine rabies is still a considerable problem, samples from wildlife species are infrequently collected and submitted for screening for rabies. A collaborative study was established involving environmental biologists and veterinarians for rabies epidemiological research in a specific ecological area located at the Sao Paulo State, Brazil. The wild animals' brains are required to be collected without skull damage because the skull's measurements are important in the identification of the captured animal species. For this purpose, samples from bats and small mammals were collected using an aspiration method by inserting a plastic pipette into the brain through the magnum foramen. While there is a progressive increase in the use of the plastic pipette technique in various studies undertaken, it is also appreciated that this method could foster collaborative research between wildlife scientists and rabies epidemiologists thus improving rabies surveillance. © 2009 Blackwell Verlag GmbH.

  11. Web Based Cattle Disease Expert System Diagnosis with forward Chaining Method

    Science.gov (United States)

    Zamsuri, Ahmad; Syafitri, Wenni; Sadar, Muhamad

    2017-12-01

    Cattle is one of the livestock who have high economic potential, whether for livestock, cattle seed, or even for food stock. Everything that comes from Cattle is a treasure for example the Milk, the Meat, and Cattle-hide. The factor that cause Cattles to die is the spread of disease that could crock up the Cattle’s health. So that the Expert system is needed to utilize and analye the Cattle’s disease so it could detect the disease without going to the veterinarian. Forward chaining method is one of the correct method in this expert system wherein began with Symptoms to determine the illness. From this matter, we built a web based expert system application on Cattles disease to ease the disease detection and showing the brief information about the Cattles itself.

  12. A comparative study of sensor fault diagnosis methods based on observer for ECAS system

    Science.gov (United States)

    Xu, Xing; Wang, Wei; Zou, Nannan; Chen, Long; Cui, Xiaoli

    2017-03-01

    The performance and practicality of electronically controlled air suspension (ECAS) system are highly dependent on the state information supplied by kinds of sensors, but faults of sensors occur frequently. Based on a non-linearized 3-DOF 1/4 vehicle model, different methods of fault detection and isolation (FDI) are used to diagnose the sensor faults for ECAS system. The considered approaches include an extended Kalman filter (EKF) with concise algorithm, a strong tracking filter (STF) with robust tracking ability, and the cubature Kalman filter (CKF) with numerical precision. We propose three filters of EKF, STF, and CKF to design a state observer of ECAS system under typical sensor faults and noise. Results show that three approaches can successfully detect and isolate faults respectively despite of the existence of environmental noise, FDI time delay and fault sensitivity of different algorithms are different, meanwhile, compared with EKF and STF, CKF method has best performing FDI of sensor faults for ECAS system.

  13. DiaTreat: a new method of communication for better diagnosis and treatment of dental problems.

    Science.gov (United States)

    Reddy, K Srinivas; Reddy, R Sunil Kumar; Sudheer, A; Reddy, R Vamshidhar; Rao, N Venugopal; Reddy, P Lakshmipathy

    2013-01-01

    The aim of this article is to present a simple method of communication between two oral health professionals so that the problem can be conveyed easily and treatment options obtained equally easily and quickly, using current electronic communication technologies. Treatment of dental problems involves a thorough understanding of the underlying dental and medical conditions. The arena of dentistry being ever changing, with new specialties arising each year, it has become virtually impossible for an average dentist to keep track of all the treatment modalities available for various problems at a given time. It is the duty of a dentist, however, to treat his patients to the best of his ability. Professional ethics bind the other health professionals to render their opinion to the dentist so that the patient will ultimately get the best possible treatment. Method of communication is the only problem remaining in the path to achieving a total oral health care. DiaTreat is a unique method of clinical charting by which a dentist can incorporate all the ailments affecting his patient, and by withholding the patients name and address, can communicate with any of his colleagues for their opinion on the best treatment option for his patient. It is a new and innovative method of communication between a dentist and specialist. Even though it has some shortcomings of its own, on a wider range, the advantages far outweigh the drawbacks of the system. CLINICAL AND ACADEMIC SIGNIFICANCE: This can also be used by educational institutes for easy communication during interdisciplinary exchanges. Improvements need to be made yet to incorporate all the ailments known in dental discipline and make communication a comprehensive one.

  14. Applied ecosystem analysis - a primer; the ecosystem diagnosis and treatment method

    International Nuclear Information System (INIS)

    Lestelle, L.C.; Mobrand, L.E.; Lichatowich, J.A.; Vogel, T.S.

    1996-05-01

    The aim of this document is to inform and instruct the reader about an approach to ecosystem management that is based upon salmon as an indicator species. It is intended to provide natural resource management professionals with the background information needed to answer questions about why and how to apply the approach. The methods and tools the authors describe are continually updated and refined, so this primer should be treated as a first iteration of a sequentially revised manual

  15. Current methods in the radiological diagnosis of oesophageal tumours. Aktuelle radiologische Diagnostik von Oesophagustumoren

    Energy Technology Data Exchange (ETDEWEB)

    Georgi, M.; Busch, H.P.; Simon, R.; Sommer, A.; Wetzel, E. (Heidelberg Univ., Mannheim (Germany, F.R.). Inst. fuer Klinische Radiologie)

    1990-09-01

    The presence of dysphagia can easily be confirmed or disproven on the basis of conventional X-ray pictures without thereby compromising the patients' well-being. Such X-ray procedures should preferably precede endoscopy, as any pathological findings thus revealed may provide clues to the use of the latter method. Double contrast procedures may yield very useful additional information in hypotension, while CT and MRT have their merits in preoperative tumour staging. (orig.).

  16. Evaluation of quatitative scintigraphic method in diagnosis of esophagic involvement of Progressive Systemic Sclerosis

    International Nuclear Information System (INIS)

    Von Muehlen, C.A.

    1985-01-01

    Twenty patients with Progressive Systemic Sclerosis are studied by scintigraphic methodology. The esophageal transit method is used for liquid and solid meals. The results are compared with the ones of a control group, without or not gastrintestinal problems but without autoimmune diasese. 99 sup(m)Tc-sulfurcolloid is used as labelling compound. The studies were done in supine and orthostatical position. (M.A.C.) [pt

  17. Cerebral Ischemia versus MS in Young Adults Clinical Imaging Diagnosis Difficulties and Recovery Methods

    OpenAIRE

    Any DOCU-AXELERAD; Dan DOCU-AXELERAD

    2012-01-01

    Ischemia in young adults is often the result of non-atherosclerotic vasculopathies, cardiac embolism or clotting disorders. One third of young adults ischemic stroke etiology remains undetermined. Materials and methods: We present the case of a patient aged 42, diagnosed with probable MS without cardiovascular or metabolic risk factors, presented to our clinic for decrease of force at right limbs and recent dysarthria. Results and discussion: The history revealed recurrent episodes of right h...

  18. Applied Ecosystem Analysis - - a Primer : EDT the Ecosystem Diagnosis and Treatment Method.

    Energy Technology Data Exchange (ETDEWEB)

    Lestelle, Lawrence C.; Mobrand, Lars E.

    1996-05-01

    The aim of this document is to inform and instruct the reader about an approach to ecosystem management that is based upon salmon as an indicator species. It is intended to provide natural resource management professionals with the background information needed to answer questions about why and how to apply the approach. The methods and tools the authors describe are continually updated and refined, so this primer should be treated as a first iteration of a sequentially revised manual.

  19. MR cisternography: a new method for the diagnosis of CSF fistulae

    International Nuclear Information System (INIS)

    Eberhardt, K.E.W.; Tomandl, B.F.; Huk, W.J.; Hollenbach, H.P.; Deimling, M.

    1997-01-01

    The aim of this study was to compare a new MRI method for detecting the existence of cerebrospinal fluid (CSF) fistulae, i. e. MR cisternography, with CT cisternography. In a prospective study, 30 patients with post-traumatic CSF fistulae were examined. The MR examinations were performed with a 1.0-T whole-body MR system, using two T2 * -weighted sequences, a 3D PSIF (time-inversed fast imaging with steady-state precession, FISP) and a 3D constructive interference steady-state (CISS) sequence. The results of MRI and CT cisternography were compared with the surgical findings. The sensitivity in detecting CSF fistulae with MR cisternography (PSIF: 89.9 %; CISS: 93.6 %) was higher than with CT cisternography (72.3 %). The sensitivity of CT cisternography at detecting CSF fistulae in patients with a size of dural lesion less than 2 mm or in patients with multiple dural lesions is significantly lower compared with the MR method. Although the localization of CSF fistulae always proved possible with MR cisternography, this could only be accomplished wih CT in 70 % of cases. The MR cisternography technique is a new examination method with a higher sensitivity for the detection of CSF fistulae than CT cisternography. The CISS technique is superior compared with PSIF and should be used in patients with high-flow CSF fistulas. (orig.)

  20. Machinery Fault Diagnosis Using Two-Channel Analysis Method Based on Fictitious System Frequency Response Function

    Directory of Open Access Journals (Sweden)

    Kihong Shin

    2015-01-01

    Full Text Available Most existing techniques for machinery health monitoring that utilize measured vibration signals usually require measurement points to be as close as possible to the expected fault components of interest. This is particularly important for implementing condition-based maintenance since the incipient fault signal power may be too small to be detected if a sensor is located further away from the fault source. However, a measurement sensor is often not attached to the ideal point due to geometric or environmental restrictions. In such a case, many of the conventional diagnostic techniques may not be successfully applicable. In this paper, a two-channel analysis method is proposed to overcome such difficulty. It uses two vibration signals simultaneously measured at arbitrary points in a machine. The proposed method is described theoretically by introducing a fictitious system frequency response function. It is then verified experimentally for bearing fault detection. The results show that the suggested method may be a good alternative when ideal points for measurement sensors are not readily available.

  1. Novel driver method to improve ordinary CCD frame rate for high-speed imaging diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Tong-Ding, E-mail: snuohui@126.com; Li, Bin-Kang; Yang, Shao-Hua; Guo, Ming-An; Yan, Ming

    2016-06-21

    The use of ordinary Charge-coupled-Device (CCD) imagers for the analysis of fast physical phenomenon is restricted because of the low-speed performance resulting from their long output times. Even though the form of Intensified-CCD (ICCD), coupled with a gated image intensifier, has extended their use for high speed imaging, the deficiency remains to be solved that ICDD could record only one image in a single shot. This paper presents a novel driver method designed to significantly improve the ordinary interline CCD burst frame rate for high-speed photography. This method is based on the use of vertical registers as storage, so that a small number of additional frames comprised of reduced-spatial-resolution images obtained via a specific sampling operation can be buffered. Hence, the interval time of the received series of images is related to the exposure and vertical transfer times only and, thus, the burst frame rate can be increased significantly. A prototype camera based on this method is designed as part of this study, exhibiting a burst rate of up to 250,000 frames per second (fps) and a capacity to record three continuous images. This device exhibits a speed enhancement of approximately 16,000 times compared with the conventional speed, with a spatial resolution reduction of only 1/4.

  2. A Sparse Modulation Signal Bispectrum Analysis Method for Rolling Element Bearing Diagnosis

    Directory of Open Access Journals (Sweden)

    Guangbin Wang

    2018-01-01

    Full Text Available Modulation signal bispectrum (MSB analysis is an effective method to obtain the fault frequency for rolling bearing, but harmonics make fault frequency dense and even frequency aliasing. Carrier frequency of bearing is generally determined by its structure and inherent characteristics and changes with the increase of the damage degree, so it is hard to be accurately found. To solve these problems, this paper proposes a sparse modulation signal bispectrum analysis method. Firstly the vibration signal is demodulated by MSB analysis and its bispectrum is obtained. After the frequency domain filtering, the carrier frequency is computed based on the characteristics of energy concentration at the carrier frequency on MSB. By shift-frequency MSB (SF-MSB, the carrier frequency is moved to the coordinate origin, the entire MSB is shifted for the same distance, and SF-MSB is obtained. At last, the bispectrum is shifted to the frequency zero point and diagonal slices are performed to obtain a sparse representation of MSB. Experimental results show that sparse MSB (S-MSB method can not only eliminate the interference of harmonic frequency, but also make the extracted characteristic frequency of fault more obvious.

  3. Application of blocking diagnosis methods to general circulation models. Part I: a novel detection scheme

    Energy Technology Data Exchange (ETDEWEB)

    Barriopedro, D. [Universidade de Lisboa, CGUL-IDL, Faculdade de Ciencias, Ed. C-8, Lisbon (Portugal); Universidad de Extremadura, Departamento de Fisica, Facultad de Ciencias, Badajoz (Spain); Garcia-Herrera, R. [Universidad Complutense de Madrid, Departamento de Fisica de la Tierra II, Facultad de C.C. Fisicas, Madrid (Spain); Trigo, R.M. [Universidade de Lisboa, CGUL-IDL, Faculdade de Ciencias, Ed. C-8, Lisbon (Portugal)

    2010-12-15

    This paper aims to provide a new blocking definition with applicability to observations and model simulations. An updated review of previous blocking detection indices is provided and some of their implications and caveats discussed. A novel blocking index is proposed by reconciling two traditional approaches based on anomaly and absolute flows. Blocks are considered from a complementary perspective as a signature in the anomalous height field capable of reversing the meridional jet-based height gradient in the total flow. The method succeeds in identifying 2-D persistent anomalies associated to a weather regime in the total flow with blockage of the westerlies. The new index accounts for the duration, intensity, extension, propagation, and spatial structure of a blocking event. In spite of its increased complexity, the detection efficiency of the method is improved without hampering the computational time. Furthermore, some misleading identification problems and artificial assumptions resulting from previous single blocking indices are avoided with the new approach. The characteristics of blocking for 40 years of reanalysis (1950-1989) over the Northern Hemisphere are described from the perspective of the new definition and compared to those resulting from two standard blocking indices and different critical thresholds. As compared to single approaches, the novel index shows a better agreement with reported proxies of blocking activity, namely climatological regions of simultaneous wave amplification and maximum band-pass filtered height standard deviation. An additional asset of the method is its adaptability to different data sets. As critical thresholds are specific of the data set employed, the method is useful for observations and model simulations of different resolutions, temporal lengths and time variant basic states, optimizing its value as a tool for model validation. Special attention has been paid on the devise of an objective scheme easily applicable

  4. Entamoeba spp. diagnosis in patients with inflmmatory diarrhea by staining, copro-antigen ELISA and multiplex PCR methods

    Directory of Open Access Journals (Sweden)

    Zahra Gharibi

    2017-10-01

    Full Text Available Objective: To evaluate Entamoeba spp. diagnosis in patients with inflammatory diarrhea by staining, copro-antigen ELISA and multiplex PCR methods. Methods: In this descriptive cross-sectional survey, 200 stool samples were randomly collected during 2015–2016. The stool samples were evaluated microscopically for the presence of the parasite using direct and formalin-ether concentration and trichrome staining methods. Then, the stool samples were examined by copro-antigen ELISA (Biomerica Company and multiplex PCR methods. Results: Of 200 samples, 17, 29 and 23 cases were positive for Entamoeba species by the staining, copro-antigen ELISA and multiplex PCR methods, respectively. Of 23 positive samples in multiplex PCR test, 13 and 10 samples were positive for Entamoeba dispar (E. dispar and Entamoeba histolytica (E. histolytica, respectively. Conclusions: Our finding indicated a relatively high prevalence of Entamoeba species in patients with inflammatory diarrhea in Ahvaz city. Due to the complications of E. histolytica/ dispar infection, the health authorities of the city must pay more attention to control and prevent the transmission of E. histolytica/dispar to individuals.

  5. Constitutionalism and Development in Nigeria: The 1999 Constitution

    African Journals Online (AJOL)

    Fr. Ikenga

    the 3 arms of government the Executive, Legislative, Judiciary, Public Service and Marketing .... Rotation principle of a presidency position in Nigeria which will cultivate a sense of ... the issues survived inclusion in the 1999 Constitution of the Federal Republic of Nigeria. 13. S. 2 of Decree No. ..... Oxford, 5th Edition p.245.

  6. The Spanish Constitution, the Constitutional Court and the Catalan Referendum

    DEFF Research Database (Denmark)

    Abat Ninet, Antoni

    2015-01-01

    and politeia that Aristotle defined now clashes between two powerful symbolic and romantic phenomena. In the Spanish-Catalan binomial scenario, there are some elements that need to be analysed to obtain a complete picture of the constitutional possibilities to of accommodating a Catalan self...

  7. Time and constitution of sense

    Directory of Open Access Journals (Sweden)

    Pedro Gerardo Acosta

    2014-06-01

    Full Text Available This article proposes a reflection over our time-consciousness under the Phenomenology of Edmund Husserl. The idea is make a release the key role of the sense constitution like the fundament and development of the ongoing intentionality, a shape that make the possibility to catch sight of the sense of every life situation like conscience experience that displays itself over the time, and open the world of the Phenomenon World, constituted in the flux and flow of our live experience. The immanent time in which the things served in a lived-present inevitably displays to its own immediate-past of retentions, then of commemorations, constituting and enabling, not just the sense of ever present, but the sense of our own past like memory and our future like expectative. This reflection is based and supporter over the text “Phenomenology Lesson of the Internal Time-Consiusness” (Husserl, 2002.

  8. Potential benefit of the CT adaptive statistical iterative reconstruction method for pediatric cardiac diagnosis

    Science.gov (United States)

    Miéville, Frédéric A.; Ayestaran, Paul; Argaud, Christophe; Rizzo, Elena; Ou, Phalla; Brunelle, Francis; Gudinchet, François; Bochud, François; Verdun, Francis R.

    2010-04-01

    Adaptive Statistical Iterative Reconstruction (ASIR) is a new imaging reconstruction technique recently introduced by General Electric (GE). This technique, when combined with a conventional filtered back-projection (FBP) approach, is able to improve the image noise reduction. To quantify the benefits provided on the image quality and the dose reduction by the ASIR method with respect to the pure FBP one, the standard deviation (SD), the modulation transfer function (MTF), the noise power spectrum (NPS), the image uniformity and the noise homogeneity were examined. Measurements were performed on a control quality phantom when varying the CT dose index (CTDIvol) and the reconstruction kernels. A 64-MDCT was employed and raw data were reconstructed with different percentages of ASIR on a CT console dedicated for ASIR reconstruction. Three radiologists also assessed a cardiac pediatric exam reconstructed with different ASIR percentages using the visual grading analysis (VGA) method. For the standard, soft and bone reconstruction kernels, the SD is reduced when the ASIR percentage increases up to 100% with a higher benefit for low CTDIvol. MTF medium frequencies were slightly enhanced and modifications of the NPS shape curve were observed. However for the pediatric cardiac CT exam, VGA scores indicate an upper limit of the ASIR benefit. 40% of ASIR was observed as the best trade-off between noise reduction and clinical realism of organ images. Using phantom results, 40% of ASIR corresponded to an estimated dose reduction of 30% under pediatric cardiac protocol conditions. In spite of this discrepancy between phantom and clinical results, the ASIR method is as an important option when considering the reduction of radiation dose, especially for pediatric patients.

  9. Selection of method is crucial for the diagnosis of porcine circovirus type 2 associated reproductive failures

    DEFF Research Database (Denmark)

    Hansen, Mette Sif; Hjulsager, Charlotte Kristiane; Bille-Hansen, Vivi

    2010-01-01

    During a 2-month period a newly repopulated Danish pig herd experienced an increase in numbers of stillborn and mummies, caused by porcine circovirus type 2 (PCV2) associated reproductive failure. Based on recordings of data over time, the progression of the clinical outbreak was studied......, it is suggested that IHC only is suited for diagnosing acute stages of reproductive failure, whereas quantitative PCR can be used as a sensitive diagnostic method within a wider time span. It seems that IgG measurements are unpredictable as indication of intrauterine infection with PCV2. Copyright © 2010 Elsevier...

  10. A comparison of imaging methods for the diagnosis of gallbladder and biliary duct carcinomas

    International Nuclear Information System (INIS)

    Kersjes, W.; Koester, O.; Heuer, M.; Schneider, B.; Bonn Univ.

    1990-01-01

    Fourteen patients with carcinomas of the gallbladder and eight patients with biliary duct carcinomas were examined by CT, sonography, percutaneous transhepatic cholangiography (PTC), endoscopic retrograde cholangiography (ERC) and angiography. The results were compared retrospectively. Sonography proved suitable as a screening method. For accurate demonstration, this should be supplemented by C.T.. PTC and ERC demonstrate intraductal extension of biliary carcinomas and of gallbladder carcinomas infiltrating the bile ducts. The value of angiography consists merely in the pre-operative demonstration of the vascular anatomy. (orig.) [de

  11. The role of methods of radiation diagnosis in detecting vascular dementia

    International Nuclear Information System (INIS)

    Sokolov, V.N.; Anishchenko, L.V.; Rozhkovsky, G.M.; Tsvigovsky, V.M.; Dorofeeva, T.K.; Stasiuk, Y.V.

    2013-01-01

    The objective of our research was to identify characteristic morphological changes in the structure of the brain, their location, the size, the study of association cortex, sub cortex, the establishment of differential diagnostic features for vascular discirculatory encephalopathy various etiologies (aneurysms, AVMs, tumor lesions of the brain, various vasculopathy ). We used a CT scanner ASTENYON-SUPER 4 (firm Toshiba), staffed workstation 'VITREA-2' and 'VITREA-3' firm 'VITAL IMAGES Inc.' (U.S. and Avanto MRI T1, 5 (Siemens). Multislice CT angiography is a fairly modern method in clinical practice and in the foreign medicine (authors)

  12. Comparison of sputum collection methods for tuberculosis diagnosis: a systematic review and pairwise and network meta-analysis.

    Science.gov (United States)

    Datta, Sumona; Shah, Lena; Gilman, Robert H; Evans, Carlton A

    2017-08-01

    The performance of laboratory tests to diagnose pulmonary tuberculosis is dependent on the quality of the sputum sample tested. The relative merits of sputum collection methods to improve tuberculosis diagnosis are poorly characterised. We therefore aimed to investigate the effects of sputum collection methods on tuberculosis diagnosis. We did a systematic review and meta-analysis to investigate whether non-invasive sputum collection methods in people aged at least 12 years improve the diagnostic performance of laboratory testing for pulmonary tuberculosis. We searched PubMed, Google Scholar, ProQuest, Web of Science, CINAHL, and Embase up to April 14, 2017, to identify relevant experimental, case-control, or cohort studies. We analysed data by pairwise meta-analyses with a random-effects model and by network meta-analysis. All diagnostic performance data were calculated at the sputum-sample level, except where authors only reported data at the individual patient-level. Heterogeneity was assessed, with potential causes identified by logistic meta-regression. We identified 23 eligible studies published between 1959 and 2017, involving 8967 participants who provided 19 252 sputum samples. Brief, on-demand spot sputum collection was the main reference standard. Pooled sputum collection increased tuberculosis diagnosis by microscopy (odds ratio [OR] 1·6, 95% CI 1·3-1·9, pmeta-analysis confirmed these findings, and revealed that both pooled and instructed spot sputum collections were similarly effective techniques for increasing the diagnostic performance of microscopy. Tuberculosis diagnoses were substantially increased by either pooled collection or by providing instruction on how to produce a sputum sample taken at any time of the day. Both interventions had a similar effect to that reported for the introduction of new, expensive laboratory tests, and therefore warrant further exploration in the drive to end the global tuberculosis epidemic. Wellcome Trust

  13. Assessment of laboratory methods used in the diagnosis of congenital toxoplasmosis after maternal treatment with spiramycin in pregnancy

    Science.gov (United States)

    2014-01-01

    Background The different laboratory methods used in the diagnosis of congenital toxoplasmosis have variable sensitivity and specificity. There is no evidence to prove that maternal treatment reduces the risk of fetal infection. The purpose of this study was to assess methods for the confirmation of congenital toxoplasmosis after maternal treatment with spiramycin during pregnancy, and to evaluate the effect of this treatment on clinical manifestations of the disease in newborns (NB). Methods This was a community-based, cross-sectional study of acute toxoplasmosis in newborns at risk of acquiring congenital infection. Participating newborns were born in the Clinical Hospital Maternity Ward of the Federal University of Goiás. Eligible participants were divided into 2 groups: group 1 consisted of 44 newborns born to mothers treated with spiramycin during pregnancy and group 2 consisted of 24 newborns born to mothers not treated with spiramycin during pregnancy because the diagnosis of toxoplasmosis was not performed. The sensitivity and specifity of PCR for T. gondii DNA in peripheral blood and serological testing for specific anti-T. gondii IgM and IgA, and the effects of maternal spiramycin treatment on these parameters, were determined by associating test results with clinical manifestations of disease. Results The sensitivity of the markers (T. gondii DNA detected by PCR, and the presence of specific anti-T. gondii IgM and IgA) for congenital toxoplasmosis was higher in group 2 than in group 1 (31.6, 68.4, 36.8% and 3.7, 25.9, 11.1% respectively). Even with a low PCR sensitivity, the group 2 results indicate the importance of developing new techniques for the diagnosis of congenital toxoplasmosis in newborns. Within group 1, 70.4% of the infected newborns were asymptomatic and, in group 2, 68.4% showed clinical manifestations of congenital toxoplasmosis. Conclusions The higher proportion of infants without clinical symptoms in group 1 (70.4%) suggests the

  14. Comparison of kDNA PCR-hybridization assay with three PCR methods for canines visceral Leishmaniasis diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Pilatti, Marcia M.; Andrade, Antero S.R. [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)], e-mail: marciapilatti@yahoo.com.br, e-mail: antero@cdtn.br; Ferreira, Sidney A. [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Dept. de Parasitologia], e-mail: saninoalmeida@gmail.com

    2009-07-01

    The sensitivity of the kDNA PCR-Hybridization assay, which uses radioactive DNA probes (labeled with {sup 32}P), was compared with three conventional PCR methods used for canine visceral leishmaniasis diagnosis. All PCR methods had two steps: a first amplification followed by hybridization or by a new amplification (nested or semi nested). Two methods (kDNA PCR-Hybridization and kDNA snPCR) used primers addressed to kinetoplast minicircles and the other two methods to the coding (LnPCR) and intergenic noncoding regions (ITS-1 nPCR) of the ribosomal rRNA genes. The comparison was accomplished in two groups of 23 infected dogs using samples collected by the conjunctival swab procedure. In the Group 1 the DNA was extracted from cotton swabs by phenol-chloroform and in Group 2 by boiling. The most efficient PCR methods in the Group 1 were those based on kDNA targets. The kDNA PCR-Hybridization was able to detect parasites in 22/23 dogs (95.6%) and in 40/46 samples (86.9%). The kDNA snPCR was positive for 21/23 dogs (91.3%) and for 40/46 samples (86.9%). The positivities of the kDNA based methods were significantly higher than the positivities verified for the methods based on ribosomal rRNA genes (p<0.05). In the Group 2 the kDNA PCR- Hybridization showed a better performance detecting parasites in 18/23 dogs (78.3%) and in 31/46 samples (67.4%), significantly higher than the other three methods (p<0.05). The higher sensitivity of the minicircle kDNA based assays reported by others was confirmed in this study and kDNA PCR-Hybridization showed the best sensitivity among the assays evaluated. (author)

  15. Comparison of kDNA PCR-hybridization assay with three PCR methods for canines visceral Leishmaniasis diagnosis

    International Nuclear Information System (INIS)

    Pilatti, Marcia M.; Andrade, Antero S.R.; Ferreira, Sidney A.

    2009-01-01

    The sensitivity of the kDNA PCR-Hybridization assay, which uses radioactive DNA probes (labeled with 32 P), was compared with three conventional PCR methods used for canine visceral leishmaniasis diagnosis. All PCR methods had two steps: a first amplification followed by hybridization or by a new amplification (nested or semi nested). Two methods (kDNA PCR-Hybridization and kDNA snPCR) used primers addressed to kinetoplast minicircles and the other two methods to the coding (LnPCR) and intergenic noncoding regions (ITS-1 nPCR) of the ribosomal rRNA genes. The comparison was accomplished in two groups of 23 infected dogs using samples collected by the conjunctival swab procedure. In the Group 1 the DNA was extracted from cotton swabs by phenol-chloroform and in Group 2 by boiling. The most efficient PCR methods in the Group 1 were those based on kDNA targets. The kDNA PCR-Hybridization was able to detect parasites in 22/23 dogs (95.6%) and in 40/46 samples (86.9%). The kDNA snPCR was positive for 21/23 dogs (91.3%) and for 40/46 samples (86.9%). The positivities of the kDNA based methods were significantly higher than the positivities verified for the methods based on ribosomal rRNA genes (p<0.05). In the Group 2 the kDNA PCR- Hybridization showed a better performance detecting parasites in 18/23 dogs (78.3%) and in 31/46 samples (67.4%), significantly higher than the other three methods (p<0.05). The higher sensitivity of the minicircle kDNA based assays reported by others was confirmed in this study and kDNA PCR-Hybridization showed the best sensitivity among the assays evaluated. (author)

  16. Multispectral photoacoustic method for the early detection and diagnosis of osteoporosis

    Science.gov (United States)

    Steinberg, Idan; Eyal, Avishay; Gannot, Israel

    2013-03-01

    Osteoporosis is a major health problem worldwide, with healthcare costs of billions of dollars annually. The risk of fracture depends on the bone mineral density (measured in clinical practice) as well as on the bone microstructure and functional status. Since pure ultrasonic methods can measure bone strength and spectroscopic optical methods can provide valuable functional information, a hybrid multispectral photoacoustic technique can be of great value. We have developed such a system based on a tunable Ti:Sapph laser at 750 - 950 nm, followed by an acousto-optic modulator to generate photoacoustic signals with frequencies of 0.5 - 2.5 MHz. Another system was based on two directly modulated 830nm laser diodes. The systems were used to photoacoustically excite the proximal end of a rat tibia. Spectrum analyzer with tracking generator was used for measuring both the amplitude and the phase at the distal end. Scanning along both the optical wavelength as well as the acoustic frequency enables full mapping of the bone transfer function. Analyzing this function along the wavelength axis allows deducing the gross biochemical composition related to the bone functional and pathological state. Analyzing the amplitude and phase along the acoustic frequency axis yields the speed of sound dispersion and the broadband ultrasonic attenuation - both have shown clinical relevance.

  17. [Vertigo and a role of neurovisual methods in it etiology and diagnosis].

    Science.gov (United States)

    Alekseeva, N S; Krotenkova, M V; Konovalov, R N; Baev, A A; Petrova, E I

    2005-01-01

    Investigation of vestibular system using a standard method of electro-nystagmography in complex otoneurologic examination does not provide enough information on the etiology of vestibular analyzer lesion, location and diffusion of the pathological process. Neurovisual methods, in particular MRI and CT, have demonstrated high diagnostic validity in such pathological states as tumors of pons cerebellum and posterior focca; infarctions in the stem and cerebellum regions. The study revealed a role of MRI and CT in etiology of vertigo and lesions of cochleovestibular analyzer. One hundred thirty patients aged 28-74 years with recurrent attacks of systemic rotary vertigo and other its appearances have been examined. In 14 (11%) patients such an attack was accompanied by loss of consciousness, falls, double-vision and other neurological symptoms. All the patients underwent otoneurological examination, computer electronystagmography, auditory evoked potentials registration, CT and MRI. It is shown that peripheral cochleovestibular syndromes caused by arterial hypertension, atherosclerosis and autonomic vascular dystonia are rarely characterized by focal cerebral changes (11 patients by CT data and 17 by MRI).

  18. Survey of the Role of Combined Screening Method with Ultrasonography in the Diagnosis of Breast Cancer

    Directory of Open Access Journals (Sweden)

    F. Gharekhanloo

    2011-01-01

    Full Text Available Introduction & Objective: The breast cancer is the most common malignancy in women and in recent years it is seen in younger ages. Because of dense breast tissue in these ages, the mammography sensitivity for breast cancer detection is reduced, so high quality ultrasonography (US as a combined screening method is effective. The aim of this study is the evaluation of the mammographic finding with the positive finding of ultrasonogarphy.Materials & Methods: In this cross-sectional study 300 cases were referred to the Mehr Medical Imaging Center for breast US and sonography of breast and axilla was performed. Mammography before or after US was also performed by another radiologist. All suspicious patients were referred for biopsy or surgery.Results: Mean age of patients was 46 y/o with the range of 32-76 y/o. Pathologic specimens approved malignancy in 21 patients and abscess in 1 patient. The most frequent symptom was palpable breast mass with mean diameter of 29 mm. Mean diameter of lymph nodes was 17.3 mm. Positive mammographic findings were seen in 85.7%and negative findings or only an asymmetric density in 14.3%.Conclusion: According to dense breast tissue especially in young women sensitivity of single screening by mammography is reduced in breast cancer detection, so combined screening with sonography and mammography especially in younger women improves the detection rate of breast carcinoma. (Sci J Hamadan Univ Med Sci 2011;17(4:57-60

  19. A Pathway Based Classification Method for Analyzing Gene Expression for Alzheimer's Disease Diagnosis.

    Science.gov (United States)

    Voyle, Nicola; Keohane, Aoife; Newhouse, Stephen; Lunnon, Katie; Johnston, Caroline; Soininen, Hilkka; Kloszewska, Iwona; Mecocci, Patrizia; Tsolaki, Magda; Vellas, Bruno; Lovestone, Simon; Hodges, Angela; Kiddle, Steven; Dobson, Richard Jb

    2016-01-01

    Recent studies indicate that gene expression levels in blood may be able to differentiate subjects with Alzheimer's disease (AD) from normal elderly controls and mild cognitively impaired (MCI) subjects. However, there is limited replicability at the single marker level. A pathway-based interpretation of gene expression may prove more robust. This study aimed to investigate whether a case/control classification model built on pathway level data was more robust than a gene level model and may consequently perform better in test data. The study used two batches of gene expression data from the AddNeuroMed (ANM) and Dementia Case Registry (DCR) cohorts. Our study used Illumina Human HT-12 Expression BeadChips to collect gene expression from blood samples. Random forest modeling with recursive feature elimination was used to predict case/control status. Age and APOE ɛ4 status were used as covariates for all analysis. Gene and pathway level models performed similarly to each other and to a model based on demographic information only. Any potential increase in concordance from the novel pathway level approach used here has not lead to a greater predictive ability in these datasets. However, we have only tested one method for creating pathway level scores. Further, we have been able to benchmark pathways against genes in datasets that had been extensively harmonized. Further work should focus on the use of alternative methods for creating pathway level scores, in particular those that incorporate pathway topology, and the use of an endophenotype based approach.

  20. Diagnosis of Magnetic Structures and Intermittency in Space Plasma Turbulence using the Method of Surrogate Data

    Science.gov (United States)

    Sahraoui, Fouad; Goldstein, Melvyn

    2008-01-01

    Several observations in space plasmas have reported the presence of coherent structures at different plasma scales. Structure formation is believed to be a direct consequence of nonlinear interactions between the plasma modes, which depend strongly on phase synchronization of those modes. Despite this important role of the phases in turbulence, very limited work has been however devoted to study the phases as a potential tracers of nonlinearities in comparison with the wealth of literature on power spectra of turbulence where phases are totally missed. We present a method based on surrogate data to systematically detect coherent structures in turbulent signals. The new method has been applied successfully to magnetosheath turbulence (Sahraoui, Phys. Rev. E, 2008, in press), where the relationship between the identified phase coherence and intermittency (classically identified as non Gaussian tails of the PDFs) as well as the energy cascade has been studied. Here we review the main results obtained in that study and show further applications to small scale solar wind turbulence. Implications of the results on theoretical modelling of space turbulence (applicability of weak/wave turbulence, its validity limits and its connection to intermittency) will be discussed.

  1. A Communicatively Constituted Online Crisis

    DEFF Research Database (Denmark)

    Valentini, Chiara; Romenti, Stefania; Kruckeberg, Dean

    2017-01-01

    into specific public crisis perceptions. Drawing from a communicative constitution perspective, the authors argue that if crises are perceptions or experiences of difficult situations that exceed a person’s current resources and coping mechanisms, and if perceptions and experiences in social media are typically...... by offering suggestions on how to study online critical conversations through the lens of a communicative constitution perspective that could inform how critical issues eventually transform and become crises and how crisis perceptions evolve and are discursively shaped by communicative practices occurring...

  2. Constitutional and acquired autosomal aneuploidy.

    Science.gov (United States)

    Jackson-Cook, Colleen

    2011-12-01

    Chromosomal imbalances can result from numerical or structural anomalies. Numerical chromosomal abnormalities are often referred to as aneuploid conditions. This article focuses on the occurrence of constitutional and acquired autosomal aneuploidy in humans. Topics covered include frequency, mosaicism, phenotypic findings, and etiology. The article concludes with a consideration of anticipated advances that might allow for the development of screening tests and/or lead to improvements in our understanding and management of the role that aneuploidy plays in the aging process and acquisition of age-related and constitutional conditions.

  3. Method and apparatus for the diagnosis of respiratory diseases and allergies

    International Nuclear Information System (INIS)

    Kremer, C.P.

    1984-01-01

    A method and apparatus are described for uniformly coating the airways of the lung of a patient with a mist formed by aspirating a liquid. The maximum size of the particles of the mist is restricted to about 1.2 microns with the major portion of the particles being in the range of 0.056 microns to 1 micron causing the mist to behave as a gas. Conduits are used for feeding the mist together with a gas containing oxygen to a patient to be inhaled during the normal breathing process, and valves are connected to the conduits for diverting the exhaled mist and gas through a discharge path. By radioactively tagging the liquid prior to production of the mist, the uniform deposition of the mist throughout the entire lung without encountering heavy accumulations in the large airways and at branch points, enables the production of high definition image scans of the lung. (author)

  4. A guide to radiologic methods of diagnosis. 9. rev. and enlarged ed.

    International Nuclear Information System (INIS)

    Thurn, P.; Buecheler, E.; Frommhold, H.

    1992-01-01

    With the 9th edition of this guide an attempt was made to take account of technical innovations in radiology and the appropriate range of indications. Attention was mainly focused on the various possibilities offered at the clinical level by high-resolution computed tomography as well as nmr imaging and digitized radiography. The chapter on radioprotection and radiation injuries has been rewritten and updated through the addition of recently prepared tables. The clinical chapters chiefly deal with the roles of nmr imaging and computed tomography. This applies in particular to discussions relating to the central nervous system, facial skull, cervical region and soft tissues. Radiologic methods of intervention were given some coverage. The chapter on contrast media and mishaps attributable to these was completely revised. (orig./MG) With 761 figs., 29 tabs [de

  5. Statistical Diagnosis Method of Conductor Motions in Superconducting Magnets to Predict their Quench Performance

    CERN Document Server

    Khomenko, B A; Rijllart, A; Sanfilippo, S; Siemko, A

    2001-01-01

    Premature training quenches are usually caused by the transient energy released within the magnet coil as it is energised. Two distinct varieties of disturbances exist. They are thought to be electrical and mechanical in origin. The first type of disturbance comes from non-uniform current distribution in superconducting cables whereas the second one usually originates from conductor motions or micro-fractures of insulating materials under the action of Lorentz forces. All of these mechanical events produce in general a rapid variation of the voltages in the so-called quench antennas and across the magnet coil, called spikes. A statistical method to treat the spatial localisation and the time occurrence of spikes will be presented. It allows identification of the mechanical weak points in the magnet without need to increase the current to provoke a quench. The prediction of the quench level from detailed analysis of the spike statistics can be expected.

  6. A review and comparison of fault detection and diagnosis methods for squirrel-cage induction motors: State of the art.

    Science.gov (United States)

    Liu, Yiqi; Bazzi, Ali M

    2017-09-01

    Preventing induction motors (IMs) from failure and shutdown is important to maintain functionality of many critical loads in industry and commerce. This paper provides a comprehensive review of fault detection and diagnosis (FDD) methods targeting all the four major types of faults in IMs. Popular FDD methods published up to 2010 are briefly introduced, while the focus of the review is laid on the state-of-the-art FDD techniques after 2010, i.e. in 2011-2015 and some in 2016. Different FDD methods are introduced and classified into four categories depending on their application domains, instead of on fault types like in many other reviews, to better reveal hidden connections and similarities of different FDD methods. Detailed comparisons of the reviewed papers after 2010 are given in tables for fast referring. Finally, a dedicated discussion session is provided, which presents recent developments, trends and remaining difficulties regarding to FDD of IMs, to inspire novel research ideas and new research possibilities. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

  7. Determination of human platelet antigen typing by molecular methods: Importance in diagnosis and early treatment of neonatal alloimmune thrombocytopenia.

    Science.gov (United States)

    Arinsburg, Suzanne A; Shaz, Beth H; Westhoff, Connie; Cushing, Melissa M

    2012-05-01

    Neonatal alloimmune thrombocytopenia (NAIT) is the most common cause of severe thrombocytopenia and intracranial hemorrhage in the perinatal period. While the gold standard for making a diagnosis of NAIT is detection of a human platelet antigen (HPA)-specific antibody in maternal serum, together with identifying an incompatibility between the parents for the cognate HPA antigen, platelet genotyping is the gold standard method for HPA typing. Platelet genotyping is critical in screening at-risk fetuses for the presence ofthe HPA corresponding to the maternal antibody. In addition, platelet genotyping may play a role in population screening to identify women at risk for sensitization, and thus, fetuses at risk for NAIT. The most commonly used methods of platelet genotyping are sequence-specific primer-polymerase chain reaction (PCR-SSP), restriction fragment length polymorphism-PCR (PCR-RFLP), and TaqMan real-time PCR. PCR-SSP and PCR-RFLP are relatively inexpensive and technically simple methods, but they are not easily automated and require expertise for reliable interpretation of results. Newer methods that allow for multiplexing, automation, and easily interpretable results, such as bead arrays, are currently in development and available for research purposes. Copyright © 2012 Wiley Periodicals, Inc.

  8. Early diagnosis of morphologic-functional changes of the airways by a simple method of inhalation scintigraphy

    International Nuclear Information System (INIS)

    Flierdt, E. van de; Bauer, R.; Laubenbacher, C.; Didic, M.; Langhammer, H.R.; Pabst, H.W.

    1992-01-01

    In order to validate a method of inhalation scintigraphy with 99m Tc-labeled human serum albumin in the early diagnosis of morphologic-functional changes of the airways 35 volunteers and patients (12 healthy non-smokers and smokers each, 11 patients with bronchitis) were studied. Deposition of the aerosol immediately after inhalation was calculated quantitatively by a ROI technique and qualitatively (scoring of central deposition, homogeneity, and recognizability of lung outline). Additionally, the regional clearance of the inhaled aerosol was determined by continuous lung imaging up to 60 min (mainly regional mucociliary removal rates). Discrimination between healthy volunteers and patients with bronchitis was possible by means of deposition patterns immediately after inhalation. On the other hand, no differences could be recognized in this way between healthy non-smokers and smokers. Regional mucociliary removal was higher in non-smokers than in smokers, but there was no difference between smokers and patients with bronchitis. (orig.) [de

  9. Importance of the radiological methods in the diagnosis of the paralytics and combined stenosis of the larynx

    International Nuclear Information System (INIS)

    Banari, I.

    2006-01-01

    In recent years there has been great progress in radiology and the investigation of imagery. These methods have been used successfully in the diagnosis of the paralytic and combined laryngeal stenosis. The value of the radiographic profile without canister; the value of the tomography, laryngography, radio cinematography, and the value of computerized tomography were analyzed in the cases of 52 patients. Research examined the value of the characteristic radiological signs: asymmetry of the glottis, deformation and enlargement of the laryngeal ventricle, and change of the shape of the sub glottal space in the affected part. The results determines the selection criterions of patients for treatment and selection of the type of the surgical intervention. (authors)

  10. Place of the imaging methods for diagnosis and treatment of primary and secondary hepatic tumors

    Energy Technology Data Exchange (ETDEWEB)

    Mircheva, M [Meditsinska Akademiya, Sofia (Bulgaria). Nauchen Institut po Vytreshni Bolesti

    1991-01-01

    A review is presented of the methods in which the imaging and treatment of liver tumors are mutually connected: ultrasound study, radioimmunoscintigraphy with {sup 111}InF(ab){sub 2}-fragments from anti-CEA monoclonal antibodies and computerized tomography (CT). Special attention has been paid to different approaches for increasing of the sensitivity and specificity of CT: contrast intensification of the image with water-soluble contrast media; bolus administration of the contrast media by dynamic CT-scanning; introduction of the contrast matter in truncus coeliacus and/or a. hepatica; late CT. From the terapeutic point of view suspending of different cytostatics in Lipiodol and their intraarterial administration are discussed. The angiographic study is a prerequisite for arterial chemotherapy. Its advantages is stressed against to transcatheter introduction of antimitotic drugs (by using of percutaneous catheters through a. brachialis, a. femoralis or by surgical implantation). The creation of conjugated chemotherapeutic polymers which helps to obtain a depot-effect in conservative treatment is mentioned as a new approach in improving the regional chemotherapy. The first results from nuclear-magnetic resonance tomography are evaluated. The tendency for integration of the individual visualization and therapeutic approaches is stressed. 58 refs.

  11. Cerebral Ischemia versus MS in Young Adults Clinical Imaging Diagnosis Difficulties and Recovery Methods

    Directory of Open Access Journals (Sweden)

    Any DOCU-AXELERAD

    2012-12-01

    Full Text Available Ischemia in young adults is often the result of non-atherosclerotic vasculopathies, cardiac embolism or clotting disorders. One third of young adults ischemic stroke etiology remains undetermined. Materials and methods: We present the case of a patient aged 42, diagnosed with probable MS without cardiovascular or metabolic risk factors, presented to our clinic for decrease of force at right limbs and recent dysarthria. Results and discussion: The history revealed recurrent episodes of right hemi-body numbness and vertigo labeled as relapse in MS. Patient is non smoker, does not take oral contraceptives and has no history of cerebrovascular disease in the family. Extensive imaging and laboratory investigations confirms the ischemic clinical picture, carotid Doppler ultrasound showing significant stenosis of the bulbo-left carotid. The patient is guided to the cardiovascular surgery clinic for specialized treatment. Two weeks postoperatively we apply a kinetic-therapy program. Conclusion: Uncertain imaging and lack of vascular and metabolic risk factors do not preclude ischemia in young adults.

  12. A Parameterized Method for Air-Quality Diagnosis and Its Applications

    Directory of Open Access Journals (Sweden)

    J. Z. Wang

    2012-01-01

    Full Text Available A parameterized method is developed to diagnose the air quality in Beijing and other cities with an index termed (parameters linking air-quality to meteorological elements PLAM derived from a correlation between PM10 and relevant weather elements based on the data between 2000 and 2007. Key weather factors for diagnosing the air pollution intensity are identified and included in PLAM that include atmospheric condensation of water vapour, wet potential equivalent temperature, and wind velocity. It is found that the poor air quality days with elevated PM10 are usually associated with higher PLAM values, featuring higher temperature, humidity, lower wind velocity, and higher stability compared to the averaged values in the same period. Both 24 h and 72 h forecasts provided useful services for the day of the opening ceremony of the Beijing Olympic Games and subsequent sport events. A correlation coefficient of 0.82 was achieved between the forecasts and (air pollution index API and 0.59 between the forecasts and observed PM10, all reaching the significant level of 0.001, for the summer period. A correction factor was also introduced to enable the PLAM to diagnose the observed PM10 concentrations all year round.

  13. Choice of urine collection methods for the diagnosis of urinary tract infection in young, febrile infants.

    Science.gov (United States)

    Schroeder, Alan R; Newman, Thomas B; Wasserman, Richard C; Finch, Stacia A; Pantell, Robert H

    2005-10-01

    The optimal method of urine collection in febrile infants is debatable; catheterization, considered more accurate, is technically difficult and invasive. To determine predictors of urethral catheterization in febrile infants and to compare bag and catheterized urine test performance characteristics. Prospective analysis of infants enrolled in the Pediatric Research in Office Settings' Febrile Infant Study. A total of 219 practices from within the Pediatric Research in Office Settings' network, including 44 states, the District of Columbia, and Puerto Rico. A total of 3066 infants aged 0 to 3 months with temperatures of 38 degrees C or higher. We calculated adjusted odds ratios for predictors of catheterization. Diagnostic test characteristics were compared between bag and catheterization. Urinary tract infection was defined as pure growth of 100 000 CFU/mL or more (bag) and 20 000 CFU/mL or more (catheterization). Seventy percent of urine samples were obtained by catheterization. Predictors of catheterization included female sex, practitioner older than 40 years, Medicaid, Hispanic ethnicity, nighttime evaluation, and severe dehydration. For leukocyte esterase levels, bag specimens demonstrated no difference in sensitivity but somewhat lower specificity (84% [bag] vs 94% [catheterization], PInfection rates were similar in bag and catheterized specimens (8.5% vs 10.8%). Ambiguous cultures were more common in bag specimens (7.4% vs 2.7%, Purinary tract infection. Although both urine cultures and urinalyses are more accurate in catheterized specimens, the magnitude of difference is small but should be factored into clinical decision making.

  14. Conventional versus molecular methods for diagnosis of tuberculosis in a tertiary care center: A study from Punjab

    Directory of Open Access Journals (Sweden)

    Shavi Nagpal

    2016-01-01

    Full Text Available Background: A fast and accurate diagnosis is necessary to control and eliminate tuberculosis (TB. There have been various studies evaluating the efficacy of polymerase chain reaction (PCR testing in clinical practice. Most of these studies have found PCR as a useful tool to diagnose TB and more so for the extra-pulmonary cases. Aims and Objectives: The aim of the study was to evaluate the results of TB by real-time PCR versus the conventional methods of diagnosis in a tertiary care center in Punjab. Materials and Methods: This study was done in a tertiary care center of Punjab to look for the results of clinical samples tested for TB using PCR, Ziehl–Neelsen staining and culture on Lowenstein–Jensen medium. 16S rRNA gene was used for Mycobacterium tuberculosis detection in PCR. This study included all samples tested for TB from July 2015 to October 2015. Results: A total of 214 samples were tested for TB using smear microscopy, culture and PCR (including 194 [90.6%] extra-pulmonary and 20 [9.3%] pulmonary samples. These included 76 cerebrospinal fluid, 30 pleural fluid, 42 tissues, 17 ascitic fluid, 13 urine, 15 bronchoalveolar lavage (BAL, 16 pus, and 5 sputum samples. Smear microscopy was positive in a total of 4 samples out of 214 (1.8%, which included 2 sputum, 1 tissue, and 1 ascitic fluid samples, while culture was positive for 6 samples (2.8% which included 2 sputum, 1 pus, 1 BAL, 1 tissue, and 1 ascitic fluid sample. The TB PCR results were positive in a total of 71 (33.1% samples out of 214. In addition, three samples also tested positive for Mycobacteria other than TB. Conclusion: PCR is a very rapid and accurate diagnostic tool for early detection of TB in particularly for extrapulmonary TB.

  15. [Constitutional mismatch repair deficiency syndrome

    NARCIS (Netherlands)

    Jongmans, M.C.J.; Gidding, C.E.M.; Loeffen, J.; Wesseling, P.; Mensenkamp, A.; Hoogerbrugge, N.

    2015-01-01

    BACKGROUND: Constitutional mismatch repair deficiency (CMMR-D) syndrome is characterised by a significantly increased risk for developing cancer in childhood. It arises when both parents have a mutation in the same mismatch repair gene and pass it on to their child. CASE DESCRIPTION: An 8-year-old

  16. The Constitution and Academic Freedom.

    Science.gov (United States)

    Gilbertson, Eric R.

    During the past 150 years U.S. courts have demonstrated a special protectiveness toward academics and academic institutions. Academic freedom was not a concern when the U.S. Constitution and the First Amendment were drafted and is not mentioned in the "Federalist Papers." However, decisions by a series of Supreme Court justices led to…

  17. Signal de-noising methods for fault diagnosis and troubleshooting at CANDU{sup ®} stations

    Energy Technology Data Exchange (ETDEWEB)

    Nasimi, Elnara; Gabbar, Hossam A., E-mail: hossam.gabbar@uoit.ca

    2014-12-15

    Highlights: • Fault modelling using a Fault Semantic Network (FSN). • Intelligent filtering techniques for signal de-noise in NPP. • Signal feature extraction is applied as integrated with FSN. • Increase signal-to-noise ratio (SNR). - Abstract: Over the past several years a number of domestic CANDU{sup ®} stations have experienced issues with neutron detection systems that challenged safety and operation. Intelligent troubleshooting methodology is required to aid in making risk-informed decisions related to design and operational activities, which can aid current stations and be used for the future generation of CANDU{sup ®} designs. Fault modelling approach using Fault Semantic Network (FSN) with risk estimation is proposed for this purpose. One major challenge in troubleshooting is the determination of accurate data. It is typical to have missing, incomplete or corrupted data points in large process data sets from dynamically changing systems. Therefore, it is expected that quality of obtained data will have a direct impact on the system's ability to recognize developing trends in the process upset situations. In order to enable fault detection process, intelligent filtering techniques are required to de-noise process data and extract valuable signal features in the presence of background noise. In this study, the impact of applying an optimized and intelligent filtering of process signals prior to data analysis is discussed. This is particularly important for neutronic signals in order to increase signal-to-noise ratio (SNR) which suffers the most during start-ups and low power operation. This work is complimentary to the previously published studies on FSN-based fault modelling in CANDU stations. The main objective of this work is to explore the potential research methods using a specific case study and, based on the results and outcomes from this work, to note the possible future improvements and innovation areas.

  18. Gastroesophageal reflux diagnosis by scintigraphic method - a comparison among different methods; Diagnostico de refluxo gastro-esofagico por metodo cintilografico - correlacao com outros metodos

    Energy Technology Data Exchange (ETDEWEB)

    Cruz, Maria das Gracas de Almedia; Penas, Maria Exposito; Maliska, Carmelindo; Fonseca, Lea Miriam B. da; Lemme, Eponina M.; Campos, Deisy Guacyaba S.; Rebelo, Ana Maria de O.; Martinho, Maria Jose R.; Dias, Vera Maria [Hospital Universitario Clementino Fraga Filho, Rio de Janeiro, RJ (Brazil). Servico de Medicina Nuclear

    1996-07-01

    The gastroesophageal reflux disease is characterized by the return of gastric liquid to the esophagus which can origin the reflux esophagitis. The aim is to evaluate the contribution of dynamic quality scintigraphy of reflux (CTR) in the diagnosis of DRGE. We studied a ground of sick people with typical symptoms and compared the results given by digestive endoscopy (EDA), the histopathology and 24 hours pHmetry. There have been evaluated 24 healthy individuals and 97 who were sick. The first ones were submitted to CTR. In 20 controlled and 34 patients, the reflux index (IR) was determined by the evaluation of the reflux material percentage in relation to the basal activity. All the sick patients were submitted to CTR and EDA. This one classified them in: group A with esophagitis 45 patients (46,4%) where 14 did the biopsy of the third segment/part from the esophagus and 16 did the long pHmetry and group B without esophagitis = 52 patients (53.6%), 26 did the biopsy and 36 the pHmetry. In group A the CTR was positive in 38 (84%), the biopsy showed esophagitis in 11 (78,6%) and the pHmetry showed normal reflux in 14 (87,5%). The positivity of the same exams in group B were of 42 (81%), 11 (42,3%) and 19 (53%) respectively. The IR were determined to the controls and the measure to the patients were of 59% and 106% respectively as p<0,0001 (test from Mann Whitney). The correlation of CTR with the other methods showed sensitivity of 84,1%, specificity of 95,8%, positive predictive value of 98,3% and negative predictive value of 67,7%. As it was showed the authors concluded that the scintigraphy method can confirm the diagnosis of DRGE in patients of typical symptomology which canbe recommended by the initial of investigation method in these conditions. (author)

  19. Automated diagnosis of myositis from muscle ultrasound: Exploring the use of machine learning and deep learning methods.

    Science.gov (United States)

    Burlina, Philippe; Billings, Seth; Joshi, Neil; Albayda, Jemima

    2017-01-01

    To evaluate the use of ultrasound coupled with machine learning (ML) and deep learning (DL) techniques for automated or semi-automated classification of myositis. Eighty subjects comprised of 19 with inclusion body myositis (IBM), 14 with polymyositis (PM), 14 with dermatomyositis (DM), and 33 normal (N) subjects were included in this study, where 3214 muscle ultrasound images of 7 muscles (observed bilaterally) were acquired. We considered three problems of classification including (A) normal vs. affected (DM, PM, IBM); (B) normal vs. IBM patients; and (C) IBM vs. other types of myositis (DM or PM). We studied the use of an automated DL method using deep convolutional neural networks (DL-DCNNs) for diagnostic classification and compared it with a semi-automated conventional ML method based on random forests (ML-RF) and "engineered" features. We used the known clinical diagnosis as the gold standard for evaluating performance of muscle classification. The performance of the DL-DCNN method resulted in accuracies ± standard deviation of 76.2% ± 3.1% for problem (A), 86.6% ± 2.4% for (B) and 74.8% ± 3.9% for (C), while the ML-RF method led to accuracies of 72.3% ± 3.3% for problem (A), 84.3% ± 2.3% for (B) and 68.9% ± 2.5% for (C). This study demonstrates the application of machine learning methods for automatically or semi-automatically classifying inflammatory muscle disease using muscle ultrasound. Compared to the conventional random forest machine learning method used here, which has the drawback of requiring manual delineation of muscle/fat boundaries, DCNN-based classification by and large improved the accuracies in all classification problems while providing a fully automated approach to classification.

  20. Automated diagnosis of myositis from muscle ultrasound: Exploring the use of machine learning and deep learning methods.

    Directory of Open Access Journals (Sweden)

    Philippe Burlina

    Full Text Available To evaluate the use of ultrasound coupled with machine learning (ML and deep learning (DL techniques for automated or semi-automated classification of myositis.Eighty subjects comprised of 19 with inclusion body myositis (IBM, 14 with polymyositis (PM, 14 with dermatomyositis (DM, and 33 normal (N subjects were included in this study, where 3214 muscle ultrasound images of 7 muscles (observed bilaterally were acquired. We considered three problems of classification including (A normal vs. affected (DM, PM, IBM; (B normal vs. IBM patients; and (C IBM vs. other types of myositis (DM or PM. We studied the use of an automated DL method using deep convolutional neural networks (DL-DCNNs for diagnostic classification and compared it with a semi-automated conventional ML method based on random forests (ML-RF and "engineered" features. We used the known clinical diagnosis as the gold standard for evaluating performance of muscle classification.The performance of the DL-DCNN method resulted in accuracies ± standard deviation of 76.2% ± 3.1% for problem (A, 86.6% ± 2.4% for (B and 74.8% ± 3.9% for (C, while the ML-RF method led to accuracies of 72.3% ± 3.3% for problem (A, 84.3% ± 2.3% for (B and 68.9% ± 2.5% for (C.This study demonstrates the application of machine learning methods for automatically or semi-automatically classifying inflammatory muscle disease using muscle ultrasound. Compared to the conventional random forest machine learning method used here, which has the drawback of requiring manual delineation of muscle/fat boundaries, DCNN-based classification by and large improved the accuracies in all classification problems while providing a fully automated approach to classification.