Health effects models for nuclear power plant accident consequence analysis. Modification of models resulting from addition of effects of exposure to alpha-emitting radionuclides: Revision 1, Part 2, Scientific bases for health effects models, Addendum 2

Energy Technology Data Exchange (ETDEWEB)

Abrahamson, S. [Wisconsin Univ., Madison, WI (United States); Bender, M.A. [Brookhaven National Lab., Upton, NY (United States); Boecker, B.B.; Scott, B.R. [Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research Inst.; Gilbert, E.S. [Pacific Northwest Lab., Richland, WA (United States)

1993-05-01

The Nuclear Regulatory Commission (NRC) has sponsored several studies to identify and quantify, through the use of models, the potential health effects of accidental releases of radionuclides from nuclear power plants. The Reactor Safety Study provided the basis for most of the earlier estimates related to these health effects. Subsequent efforts by NRC-supported groups resulted in improved health effects models that were published in the report entitled {open_quotes}Health Effects Models for Nuclear Power Plant Consequence Analysis{close_quotes}, NUREG/CR-4214, 1985 and revised further in the 1989 report NUREG/CR-4214, Rev. 1, Part 2. The health effects models presented in the 1989 NUREG/CR-4214 report were developed for exposure to low-linear energy transfer (LET) (beta and gamma) radiation based on the best scientific information available at that time. Since the 1989 report was published, two addenda to that report have been prepared to (1) incorporate other scientific information related to low-LET health effects models and (2) extend the models to consider the possible health consequences of the addition of alpha-emitting radionuclides to the exposure source term. The first addendum report, entitled {open_quotes}Health Effects Models for Nuclear Power Plant Accident Consequence Analysis, Modifications of Models Resulting from Recent Reports on Health Effects of Ionizing Radiation, Low LET Radiation, Part 2: Scientific Bases for Health Effects Models,{close_quotes} was published in 1991 as NUREG/CR-4214, Rev. 1, Part 2, Addendum 1. This second addendum addresses the possibility that some fraction of the accident source term from an operating nuclear power plant comprises alpha-emitting radionuclides. Consideration of chronic high-LET exposure from alpha radiation as well as acute and chronic exposure to low-LET beta and gamma radiations is a reasonable extension of the health effects model.

Postulated weather modification effects of large energy releases

Energy Technology Data Exchange (ETDEWEB)

Ramsdell, J.V.; Scott, B.C.; Orgill, M.M.; Renne, D.S.; Hubbard, J.E.; McGinnis, K.A.

1977-02-01

Postulated impacts of large energy releases were examined in the light of existing technical information. The magnitudes of direct atmospheric modifications were estimated, and the ecological and economic implications of the modifications were explored. Energy releases from energy centers (10 to 40 power plants at a single site) and individual power plant clusters (1 to 4 power plants) were considered. In the atmosphere the energy will exist initially as increased temperature (sensible heat), moisture (latent heat), and air motion (kinetic energy). Addition of energy could result in increased cloudiness and fog, and changed precipitation patterns. A framework for economic analysis of the impacts of the postulated atmospheric modifications was established on the basis of costs and benefits. Willingness-to-pay was selected as the appropriate measure for valuing each impact. The primary and secondary atmospheric modifications may affect recreation, transportation, and aesthetics as well as agriculture and forestry. Economic values can be placed on some of the effects. However, the willingness of people to pay to gain benefits and avoid damages in many cases can only be determined through extensive surveys. The economic consequences of a given energy release would be highly site specific.

Postulated weather modification effects of large energy releases

International Nuclear Information System (INIS)

Ramsdell, J.V.; Scott, B.C.; Orgill, M.M.; Renne, D.S.; Hubbard, J.E.; McGinnis, K.A.

1977-02-01

Postulated impacts of large energy releases were examined in the light of existing technical information. The magnitudes of direct atmospheric modifications were estimated, and the ecological and economic implications of the modifications were explored. Energy releases from energy centers (10 to 40 power plants at a single site) and individual power plant clusters (1 to 4 power plants) were considered. In the atmosphere the energy will exist initially as increased temperature (sensible heat), moisture (latent heat), and air motion (kinetic energy). Addition of energy could result in increased cloudiness and fog, and changed precipitation patterns. A framework for economic analysis of the impacts of the postulated atmospheric modifications was established on the basis of costs and benefits. Willingness-to-pay was selected as the appropriate measure for valuing each impact. The primary and secondary atmospheric modifications may affect recreation, transportation, and aesthetics as well as agriculture and forestry. Economic values can be placed on some of the effects. However, the willingness of people to pay to gain benefits and avoid damages in many cases can only be determined through extensive surveys. The economic consequences of a given energy release would be highly site specific

Uncertainty and sensitivity analysis in nuclear accident consequence assessment

International Nuclear Information System (INIS)

Karlberg, Olof.

1989-01-01

This report contains the results of a four year project in research contracts with the Nordic Cooperation in Nuclear Safety and the National Institute for Radiation Protection. An uncertainty/sensitivity analysis methodology consisting of Latin Hypercube sampling and regression analysis was applied to an accident consequence model. A number of input parameters were selected and the uncertainties related to these parameter were estimated within a Nordic group of experts. Individual doses, collective dose, health effects and their related uncertainties were then calculated for three release scenarios and for a representative sample of meteorological situations. From two of the scenarios the acute phase after an accident were simulated and from one the long time consequences. The most significant parameters were identified. The outer limits of the calculated uncertainty distributions are large and will grow to several order of magnitudes for the low probability consequences. The uncertainty in the expectation values are typical a factor 2-5 (1 Sigma). The variation in the model responses due to the variation of the weather parameters is fairly equal to the parameter uncertainty induced variation. The most important parameters showed out to be different for each pathway of exposure, which could be expected. However, the overall most important parameters are the wet deposition coefficient and the shielding factors. A general discussion of the usefulness of uncertainty analysis in consequence analysis is also given. (au)

Consequence analysis for nuclear reactors, Yongbyon

International Nuclear Information System (INIS)

Kang, Taewook; Jae, Moosung

2017-01-01

Since the Fukushima nuclear power plant accidents in 2011, there have been an increased public anxiety about the safety of nuclear power plants in Korea. The lack of safeguards and facility aging issues at the Yongbyon nuclear facilities have increased doubts. In this study, the consequence analysis for the 5-MWe graphite-moderated reactor in North Korea was performed. Various accident scenarios including accidents at the interim spent fuel pool in the 5-MWe reactor have been developed and evaluated quantitatively. Since data on the design and safety system of nuclear facilities are currently insufficient, the release fractions were set by applying the alternative source terms made for utilization in the analysis of a severe accident by integrating the results of studies of severe accidents occurred before. The calculation results show the early fatality zero deaths and latent cancer fatality about only 13 deaths in Seoul. Thus, actual impacts of a radiological release will be psychological in terms of downwind perceptions and anxiety on the part of potentially exposed populations. Even considering the simultaneous accident occurrence in both 5-MWe graphite-moderated reactor and 100-MWt light water reactor, the consequence analysis using the MACCS2 code shows no significant damage to people in South Korea. (author)

Hanford Waste Tank Bump Accident and Consequence Analysis

International Nuclear Information System (INIS)

BRATZEL, D.R.

2000-01-01

This report provides a new evaluation of the Hanford tank bump accident analysis and consequences for incorporation into the Authorization Basis. The analysis scope is for the safe storage of waste in its current configuration in single-shell and double-shell tanks

Economic Consequence Analysis of Disasters: The ECAT Software Tool

Energy Technology Data Exchange (ETDEWEB)

Rose, Adam; Prager, Fynn; Chen, Zhenhua; Chatterjee, Samrat; Wei, Dan; Heatwole, Nathaniel; Warren, Eric

2017-04-15

This study develops a methodology for rapidly obtaining approximate estimates of the economic consequences from numerous natural, man-made and technological threats. This software tool is intended for use by various decision makers and analysts to obtain estimates rapidly. It is programmed in Excel and Visual Basic for Applications (VBA) to facilitate its use. This tool is called E-CAT (Economic Consequence Analysis Tool) and accounts for the cumulative direct and indirect impacts (including resilience and behavioral factors that significantly affect base estimates) on the U.S. economy. E-CAT is intended to be a major step toward advancing the current state of economic consequence analysis (ECA) and also contributing to and developing interest in further research into complex but rapid turnaround approaches. The essence of the methodology involves running numerous simulations in a computable general equilibrium (CGE) model for each threat, yielding synthetic data for the estimation of a single regression equation based on the identification of key explanatory variables (threat characteristics and background conditions). This transforms the results of a complex model, which is beyond the reach of most users, into a "reduced form" model that is readily comprehensible. Functionality has been built into E-CAT so that its users can switch various consequence categories on and off in order to create customized profiles of economic consequences of numerous risk events. E-CAT incorporates uncertainty on both the input and output side in the course of the analysis.

Toxic release consequence analysis tool (TORCAT) for inherently safer design plant

International Nuclear Information System (INIS)

Shariff, Azmi Mohd; Zaini, Dzulkarnain

2010-01-01

Many major accidents due to toxic release in the past have caused many fatalities such as the tragedy of MIC release in Bhopal, India (1984). One of the approaches is to use inherently safer design technique that utilizes inherent safety principle to eliminate or minimize accidents rather than to control the hazard. This technique is best implemented in preliminary design stage where the consequence of toxic release can be evaluated and necessary design improvements can be implemented to eliminate or minimize the accidents to as low as reasonably practicable (ALARP) without resorting to costly protective system. However, currently there is no commercial tool available that has such capability. This paper reports on the preliminary findings on the development of a prototype tool for consequence analysis and design improvement via inherent safety principle by utilizing an integrated process design simulator with toxic release consequence analysis model. The consequence analysis based on the worst-case scenarios during process flowsheeting stage were conducted as case studies. The preliminary finding shows that toxic release consequences analysis tool (TORCAT) has capability to eliminate or minimize the potential toxic release accidents by adopting the inherent safety principle early in preliminary design stage.

Drug Addiction and DNA Modifications.

Science.gov (United States)

Brown, Amber N; Feng, Jian

2017-01-01

Drug addiction is a complex disorder which can be influenced by both genetic and environmental factors. Research has shown that epigenetic modifications can translate environmental signals into changes in gene expression, suggesting that epigenetic changes may underlie the causes and possibly treatment of substance use disorders. This chapter will focus on epigenetic modifications to DNA, which include DNA methylation and several recently defined additional DNA epigenetic changes. We will discuss the functions of DNA modifications and methods for detecting them, followed by a description of the research investigating the function and consequences of drug-induced changes in DNA methylation patterns. Understanding these epigenetic changes may provide us translational tools for the diagnosis and treatment of addiction in the future.

CoverageAnalyzer (CAn: A Tool for Inspection of Modification Signatures in RNA Sequencing Profiles

Directory of Open Access Journals (Sweden)

Ralf Hauenschild

2016-11-01

Full Text Available Combination of reverse transcription (RT and deep sequencing has emerged as a powerful instrument for the detection of RNA modifications, a field that has seen a recent surge in activity because of its importance in gene regulation. Recent studies yielded high-resolution RT signatures of modified ribonucleotides relying on both sequence-dependent mismatch patterns and reverse transcription arrests. Common alignment viewers lack specialized functionality, such as filtering, tailored visualization, image export and differential analysis. Consequently, the community will profit from a platform seamlessly connecting detailed visual inspection of RT signatures and automated screening for modification candidates. CoverageAnalyzer (CAn was developed in response to the demand for a powerful inspection tool. It is freely available for all three main operating systems. With SAM file format as standard input, CAn is an intuitive and user-friendly tool that is generally applicable to the large community of biomedical users, starting from simple visualization of RNA sequencing (RNA-Seq data, up to sophisticated modification analysis with significance-based modification candidate calling.

Evaluation of Proteomic Search Engines for the Analysis of Histone Modifications

Science.gov (United States)

2015-01-01

Identification of histone post-translational modifications (PTMs) is challenging for proteomics search engines. Including many histone PTMs in one search increases the number of candidate peptides dramatically, leading to low search speed and fewer identified spectra. To evaluate database search engines on identifying histone PTMs, we present a method in which one kind of modification is searched each time, for example, unmodified, individually modified, and multimodified, each search result is filtered with false discovery rate less than 1%, and the identifications of multiple search engines are combined to obtain confident results. We apply this method for eight search engines on histone data sets. We find that two search engines, pFind and Mascot, identify most of the confident results at a reasonable speed, so we recommend using them to identify histone modifications. During the evaluation, we also find some important aspects for the analysis of histone modifications. Our evaluation of different search engines on identifying histone modifications will hopefully help those who are hoping to enter the histone proteomics field. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium with the data set identifier PXD001118. PMID:25167464

Evaluation of proteomic search engines for the analysis of histone modifications.

Science.gov (United States)

Yuan, Zuo-Fei; Lin, Shu; Molden, Rosalynn C; Garcia, Benjamin A

2014-10-03

Identification of histone post-translational modifications (PTMs) is challenging for proteomics search engines. Including many histone PTMs in one search increases the number of candidate peptides dramatically, leading to low search speed and fewer identified spectra. To evaluate database search engines on identifying histone PTMs, we present a method in which one kind of modification is searched each time, for example, unmodified, individually modified, and multimodified, each search result is filtered with false discovery rate less than 1%, and the identifications of multiple search engines are combined to obtain confident results. We apply this method for eight search engines on histone data sets. We find that two search engines, pFind and Mascot, identify most of the confident results at a reasonable speed, so we recommend using them to identify histone modifications. During the evaluation, we also find some important aspects for the analysis of histone modifications. Our evaluation of different search engines on identifying histone modifications will hopefully help those who are hoping to enter the histone proteomics field. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium with the data set identifier PXD001118.

DNA modification by alkylating compounds

Energy Technology Data Exchange (ETDEWEB)

Kruglyakova, E.E.

1985-09-01

Results are given for research on the physico-chemical properties of alkylating compounds - nitroso alkyl ureas (NAU) which possess a broad spectrum of biological activity, such as mutagenic, carcinogenic, and anti-tumor action that is due to the alkylation and carbamoylation of DNA as well as other cellular components. Identified chemical products of NAU interaction with DNA and its components are cited. Structural conversions of a DNA macromolecule resulting from its chemical modification are examined. NAU are used to discuss possible biological consequences of DNA modification. 148 references.

Safety of modifications at nuclear power plants - the role of minor modifications and human and organisational factors

International Nuclear Information System (INIS)

2005-01-01

in the present report. The ultimate responsibility for plant safety lies with the licensee. Consequently, modification processes at the utilities are controlled by written procedures. The modification processes vary depending on the type and scope of the modification. Large modifications generally lead to fewer problems, because these projects are given a great deal of attention and resources together with flexibility in milestones and timing of activities. In contrast, minor modifications seem to, according to recent experience, represent a generic challenge because they are less likely to be recognised as safety significant. Similar kinds of challenges may arise during plant maintenance, when changes in the design or materials may be made without anyone recognising that the maintenance work has actually led to functional modification of plant equipment. A modification process, in which possible safety influences are assessed early, may improve nuclear safety to a significant extent and, at the same time, reduce overall modification cost. Screening of intended changes can be used to estimate design and analysis effort required in the modification process. In the screening, it should be observed that system complexity sometimes may have unexpected impacts. Screening criteria should address the safety significance of the systems and components modified. Also, the impact of the changes on tasks performed by operators and maintainers should be assessed. Major modification projects should always include an analysis of both technical and human contributions to plant operability and maintainability as a part of their comprehensive review process. It is important to create awareness and understanding of the potential safety impacts of modifications at NPPs. This awareness may be improved by collecting and disseminating information about modification-related events. Good results may only be achieved by integrating technical and human factors considerations in the safety

40 CFR 1400.5 - Internet access to certain off-site consequence analysis data elements.

Science.gov (United States)

2010-07-01

... consequence analysis data elements. 1400.5 Section 1400.5 Protection of Environment ENVIRONMENTAL PROTECTION... UNDER THE CLEAN AIR ACT SECTION 112(r)(7); DISTRIBUTION OF OFF-SITE CONSEQUENCE ANALYSIS INFORMATION DISTRIBUTION OF OFF-SITE CONSEQUENCE ANALYSIS INFORMATION Public Access § 1400.5 Internet access to certain off...

40 CFR 1400.8 - Access to off-site consequence analysis information by Federal government officials.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Access to off-site consequence... MANAGEMENT PROGRAMS UNDER THE CLEAN AIR ACT SECTION 112(r)(7); DISTRIBUTION OF OFF-SITE CONSEQUENCE ANALYSIS INFORMATION DISTRIBUTION OF OFF-SITE CONSEQUENCE ANALYSIS INFORMATION Access to Off-Site Consequence Analysis...

Coal handling system structural analysis for modifications or plant life extension

International Nuclear Information System (INIS)

Dufault, A.; Weider, F.; Doyle, P.

1989-01-01

One neglected aspect of plant modification or life extension is the extent to which previous projects may have affected the integrity of existing structures. During the course of a project to backfit fire protection facilities to existing coal handling systems, it was found that past modifications had added loads to existing coal handling structures which exceeded the available design margin. This paper describes the studies that discovered the original problem areas, as well as the detailed analysis and design considerations used to repair these structures

Genetic analysis of the heparan modification network in Caenorhabditis elegans.

Science.gov (United States)

Townley, Robert A; Bülow, Hannes E

2011-05-13

Heparan sulfates (HS) are highly modified sugar polymers in multicellular organisms that function in cell adhesion and cellular responses to protein signaling. Functionally distinct, cell type-dependent HS modification patterns arise as the result of a conserved network of enzymes that catalyze deacetylations, sulfations, and epimerizations in specific positions of the sugar residues. To understand the genetic interactions of the enzymes during the HS modification process, we have measured the composition of HS purified from mutant strains of Caenorhabditis elegans. From these measurements we have developed a genetic network model of HS modification. We find the interactions to be highly recursive positive feed-forward and negative feedback loops. Our genetic analyses show that the HS C-5 epimerase hse-5, the HS 2-O-sulfotransferase hst-2, or the HS 6-O-sulfotransferase hst-6 inhibit N-sulfation. In contrast, hse-5 stimulates both 2-O- and 6-O-sulfation and, hst-2 and hst-6 inhibit 6-O- and 2-O-sulfation, respectively. The effects of hst-2 and hst-6 on N-sulfation, 6-O-sulfation, and 2-O-sulfation appear largely dependent on hse-5 function. This core of regulatory interactions is further modulated by 6-O-endosulfatase activity (sul-1). 47% of all 6-O-sulfates get removed from HS and this editing process is dependent on hst-2, thereby providing additional negative feedback between 2-O- and 6-O-sulfation. These findings suggest that the modification patterns are highly sensitive to the relative composition of the HS modification enzymes. Our comprehensive genetic analysis forms the basis of understanding the HS modification network in metazoans.

Genetic Analysis of the Heparan Modification Network in Caenorhabditis elegans*

Science.gov (United States)

Townley, Robert A.; Bülow, Hannes E.

2011-01-01

Heparan sulfates (HS) are highly modified sugar polymers in multicellular organisms that function in cell adhesion and cellular responses to protein signaling. Functionally distinct, cell type-dependent HS modification patterns arise as the result of a conserved network of enzymes that catalyze deacetylations, sulfations, and epimerizations in specific positions of the sugar residues. To understand the genetic interactions of the enzymes during the HS modification process, we have measured the composition of HS purified from mutant strains of Caenorhabditis elegans. From these measurements we have developed a genetic network model of HS modification. We find the interactions to be highly recursive positive feed-forward and negative feedback loops. Our genetic analyses show that the HS C-5 epimerase hse-5, the HS 2-O-sulfotransferase hst-2, or the HS 6-O-sulfotransferase hst-6 inhibit N-sulfation. In contrast, hse-5 stimulates both 2-O- and 6-O-sulfation and, hst-2 and hst-6 inhibit 6-O- and 2-O-sulfation, respectively. The effects of hst-2 and hst-6 on N-sulfation, 6-O-sulfation, and 2-O-sulfation appear largely dependent on hse-5 function. This core of regulatory interactions is further modulated by 6-O-endosulfatase activity (sul-1). 47% of all 6-O-sulfates get removed from HS and this editing process is dependent on hst-2, thereby providing additional negative feedback between 2-O- and 6-O-sulfation. These findings suggest that the modification patterns are highly sensitive to the relative composition of the HS modification enzymes. Our comprehensive genetic analysis forms the basis of understanding the HS modification network in metazoans. PMID:21454666

Consequences of Modification of Photosystem Stoichiometry and Amount in Cyanobacteria

Energy Technology Data Exchange (ETDEWEB)

Vermaas, Willem [Arizona State Univ., Tempe, AZ (United States)

2016-12-13

The proposed research seeks to address two interconnected, important questions that impact photosynthetic processes and that reflect key differences between the photosynthetic systems of cyanobacteria and plants or algae. The first question is what are the reasons and consequences of the high photosystem I / photosystem II (PS I/PS II) ratio in many cyanobacteria, vs. a ratio that is close to unity in many plants and algae. The corresponding hypothesis is that most of PS I functions in cyclic electron transport, and that reduction in PS I will result primarily in a shortage of ATP rather than reducing power. This hypothesis will be tested by reducing the amount of PS I by changing the promoter region of the psaAB operon in the cyanobacterium Synechocystis sp. PCC 6803 and generating a range of mutants with different PS I content and thereby different PS I/PS II ratios, with some of the mutants having a PS II/PS I ratio closer to that in plants. The resulting mutants will be probed in terms of their growth rates, electron transfer rates, and P700 redox kinetics. A second question relates to a Mehler-type reaction catalyzed by two flavoproteins, Flv1 and Flv3, that accept electrons from PS I and that potentially function as an electron safety valve leading to no useful purpose of the photosynthesis-generated electrons. The hypothesis to be tested is that Flv1 and Flv3 use the electrons for useful purposes such as cyclic electron flow around PS I. This hypothesis will be tested by analysis of a mutant strain lacking flv3, the gene for one of the flavoproteins. This research is important for a more detailed understanding of the consequences of photosystem stoichiometry and amounts in a living system. Such an understanding is critical for not only insights in the regulatory systems of the organism but also to guide the development of biological or bio-hybrid systems for solar energy conversion into fuels.

A probabilistic generative model for quantification of DNA modifications enables analysis of demethylation pathways.

Science.gov (United States)

Äijö, Tarmo; Huang, Yun; Mannerström, Henrik; Chavez, Lukas; Tsagaratou, Ageliki; Rao, Anjana; Lähdesmäki, Harri

2016-03-14

We present a generative model, Lux, to quantify DNA methylation modifications from any combination of bisulfite sequencing approaches, including reduced, oxidative, TET-assisted, chemical-modification assisted, and methylase-assisted bisulfite sequencing data. Lux models all cytosine modifications (C, 5mC, 5hmC, 5fC, and 5caC) simultaneously together with experimental parameters, including bisulfite conversion and oxidation efficiencies, as well as various chemical labeling and protection steps. We show that Lux improves the quantification and comparison of cytosine modification levels and that Lux can process any oxidized methylcytosine sequencing data sets to quantify all cytosine modifications. Analysis of targeted data from Tet2-knockdown embryonic stem cells and T cells during development demonstrates DNA modification quantification at unprecedented detail, quantifies active demethylation pathways and reveals 5hmC localization in putative regulatory regions.

40 CFR 1400.9 - Access to off-site consequence analysis information by State and local government officials.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Access to off-site consequence... CONSEQUENCE ANALYSIS INFORMATION DISTRIBUTION OF OFF-SITE CONSEQUENCE ANALYSIS INFORMATION Access to Off-Site Consequence Analysis Information by Government Officials. § 1400.9 Access to off-site consequence analysis...

Research on Browsing Behavior in the Libraries: An Empirical Analysis of Consequences, Success and Influences

Directory of Open Access Journals (Sweden)

Shan-Ju L. Chang

2000-12-01

Full Text Available Browsing as an important part of human information behavior has been observed and investigated in the context of information seeking in the library in general and has assumed greater importance in human-machine interaction in particular. However, the nature and consequences of browsing are not well understood, and little is known of the success rate of such behavior.In this research, exploratory empirical case studies from three types of libraries were conducted, using questionnaires, observation logs, interviews, and computer search logs, to derive the empirical evidence to understand, from the user point of view, what are the consequences of browsing, what constitutes successful browsing, and what factors influence the extent of browsing. Content analysis and statistical analysis were conducted to analyze and synthesize the data. The research results show: (1 There are nine categories of the consequence of browsing, including accidental findings, modification of information need, found the desirable information, learning, feeling relaxation/recreational, information gathering, keeping updated, satisfying curiosity, and not finding what is needed. (2 Four factors that produce successful browsing: intention, the amount or quality of information, the utility of what is found, and help for solving problem or making judgment. (3 Three types of reasons for unsuccessful experience in browsing: not finding what one wanted, inadequate volume or quality of information, and not finding some things useful or interesting. (4 Three types of reasons for partial success: found the intended object but not happy with the quality or amount of information in it, not finding what one wanted but discovering new or potential useful information, not accomplish one purpose but achieve another one given multiple purposes. (5 The influential factors that affect the extent one engages in browsing include browser’s time, scheme of information organization, proximity to

40 CFR 1400.3 - Public access to paper copies of off-site consequence analysis information.

Science.gov (United States)

2010-07-01

...-site consequence analysis information. 1400.3 Section 1400.3 Protection of Environment ENVIRONMENTAL... PROGRAMS UNDER THE CLEAN AIR ACT SECTION 112(r)(7); DISTRIBUTION OF OFF-SITE CONSEQUENCE ANALYSIS INFORMATION DISTRIBUTION OF OFF-SITE CONSEQUENCE ANALYSIS INFORMATION Public Access § 1400.3 Public access to...

Consequence Analysis of the MHTGR and PBMR

International Nuclear Information System (INIS)

Jeong, Jong Tae; Yang, Joon Eon; Lee, Won Jae

2006-01-01

The probabilistic safety assessment of the VHTR design provides a systematic analysis to identify and quantify all risks that the plant imposes to the operators, general public, and the environment and thus demonstrates compliance to regulatory risk criteria. During the preliminary conceptual design of VHTR in Korea, both block- and pebble type-fuel are considered. Therefore, the consequence analysis of VHTR using both types of fuel were made in order to obtain the basic insights for the classification of events and the formation of the PSA framework of the VHTR

Modification and analysis of engineering hot spot factor of HFETR

International Nuclear Information System (INIS)

Hu Yuechun; Deng Caiyu; Li Haitao; Xu Taozhong; Mo Zhengyu

2014-01-01

This paper presents the modification and analysis of engineering hot spot factors of HFETR. The new factors are applied in the fuel temperature analysis and the estimated value of the safety allowable operating power of HFETR. The result shows the maximum cladding temperature of the fuel is lower when the new factor are in utilization, and the safety allowable operating power of HFETR if higher, thus providing the economical efficiency of HFETR. (authors)

Minimal modification to tribimaximal mixing

International Nuclear Information System (INIS)

He Xiaogang; Zee, A.

2011-01-01

We explore some ways of minimally modifying the neutrino mixing matrix from tribimaximal, characterized by introducing at most one mixing angle and a CP violating phase thus extending our earlier work. One minimal modification, motivated to some extent by group theoretic considerations, is a simple case with the elements V α2 of the second column in the mixing matrix equal to 1/√(3). Modifications by keeping one of the columns or one of the rows unchanged from tribimaximal mixing all belong to the class of minimal modification. Some of the cases have interesting experimentally testable consequences. In particular, the T2K and MINOS collaborations have recently reported indications of a nonzero θ 13 . For the cases we consider, the new data sharply constrain the CP violating phase angle δ, with δ close to 0 (in some cases) and π disfavored.

Debye screening modifications in ponderomotive effects

International Nuclear Information System (INIS)

Sodha, M.S.; Subbarao, D.

1979-01-01

The effective Debye screening length is shown to be increased in the presence of a high-power electromagnetic wave. The consequent modifications in ponderomotive redistributive effects and strong violations of charge neutrality have been shown to be in agreement with recent laser-plasma experiments

MICROSTRUCTURE MODIFICATIONS INDUCED IN SPRUCE WOOD BY FREEZING

Directory of Open Access Journals (Sweden)

Maria Bernadett SZMUTKU

2011-12-01

Full Text Available Scanning Electron Microscopy (SEM is amodern, non-invasive method for objective andspecialized image analysis of anatomical materialfeatures at microscopic level. Referring to wood, itoffers the possibility to view in 3D a bunch ofneighboring cells, in all three grain directions.This allows the imaging of modifications thatmight appear in the structure of the wood cellmembrane (e.g. micro-fissures caused by differentfactors, including temperature variations. This paperpresents the results of the SEM analysis performedon European spruce (Picea abies samples, cut fromboards which were subjected to freezing and thawingunder different conditions of temperature variationand time of exposure.The main aim of this research was to reveal theconditions which determine the occurrence of microfissuresin the cell wall and consequently lead tostrength losses in wood.

Status of large-scale analysis of post-translational modifications by mass spectrometry

DEFF Research Database (Denmark)

Olsen, Jesper V; Mann, Matthias

2013-01-01

Cellular function can be controlled through the gene expression program but often protein post translations modifications (PTMs) provide a more precisely and elegant mechanism. Key functional roles of specific modification events for instance during the cell cycle have been known for decades...... of protein modifications. For many PTMs, including phosphorylation, ubiquitination, glycosylation and acetylation, tens of thousands of sites can now be confidently identified and localized in the sequence of the protein. Quantitation of PTM levels between different cellular states is likewise established......, with label-free methods showing particular promise. It is also becoming possible to determine the absolute occupancy or stoichiometry of PTMS sites on a large scale. Powerful software for the bioinformatic analysis of thousands of PTM sites has been developed. However, a complete inventory of sites has...

Modification of the SAS4A Safety Analysis Code for Integration with the ADAPT Discrete Dynamic Event Tree Framework.

Energy Technology Data Exchange (ETDEWEB)

Jankovsky, Zachary Kyle [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Denman, Matthew R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2017-05-01

It is difficult to assess the consequences of a transient in a sodium-cooled fast reactor (SFR) using traditional probabilistic risk assessment (PRA) methods, as numerous safety-related sys- tems have passive characteristics. Often there is significant dependence on the value of con- tinuous stochastic parameters rather than binary success/failure determinations. One form of dynamic PRA uses a system simulator to represent the progression of a transient, tracking events through time in a discrete dynamic event tree (DDET). In order to function in a DDET environment, a simulator must have characteristics that make it amenable to changing physical parameters midway through the analysis. The SAS4A SFR system analysis code did not have these characteristics as received. This report describes the code modifications made to allow dynamic operation as well as the linking to a Sandia DDET driver code. A test case is briefly described to demonstrate the utility of the changes.

Surface charging, discharging and chemical modification at a sliding contact

DEFF Research Database (Denmark)

Singh, Shailendra Vikram; Kusano, Yukihiro; Morgen, Per

2012-01-01

Electrostatic charging, discharging, and consequent surface modification induced by sliding dissimilar surfaces have been studied. The surface-charge related phenomena were monitored by using a home-built capacitive, non-contact electrical probe, and the surface chemistry was studied by X...... are also able to comment on the behavior and the charge decay time in the ambient air-like condition, once the sliding contact is discontinued. XPS analysis showed a marginal deoxidation effect on the polyester disks due to the charging and discharging of the surfaces. Moreover, these XPS results clearly...

Cassini Spacecraft Uncertainty Analysis Data and Methodology Review and Update/Volume 1: Updated Parameter Uncertainty Models for the Consequence Analysis

Energy Technology Data Exchange (ETDEWEB)

WHEELER, TIMOTHY A.; WYSS, GREGORY D.; HARPER, FREDERICK T.

2000-11-01

Uncertainty distributions for specific parameters of the Cassini General Purpose Heat Source Radioisotope Thermoelectric Generator (GPHS-RTG) Final Safety Analysis Report consequence risk analysis were revised and updated. The revisions and updates were done for all consequence parameters for which relevant information exists from the joint project on Probabilistic Accident Consequence Uncertainty Analysis by the United States Nuclear Regulatory Commission and the Commission of European Communities.

Demonstration uncertainty/sensitivity analysis using the health and economic consequence model CRAC2

International Nuclear Information System (INIS)

Alpert, D.J.; Iman, R.L.; Johnson, J.D.; Helton, J.C.

1985-01-01

This paper summarizes a demonstration uncertainty/sensitivity analysis performed on the reactor accident consequence model CRAC2. The study was performed with uncertainty/sensitivity analysis techniques compiled as part of the MELCOR program. The principal objectives of the study were: 1) to demonstrate the use of the uncertainty/sensitivity analysis techniques on a health and economic consequence model, 2) to test the computer models which implement the techniques, 3) to identify possible difficulties in performing such an analysis, and 4) to explore alternative means of analyzing, displaying, and describing the results. Demonstration of the applicability of the techniques was the motivation for performing this study; thus, the results should not be taken as a definitive uncertainty analysis of health and economic consequences. Nevertheless, significant insights on health and economic consequence analysis can be drawn from the results of this type of study. Latin hypercube sampling (LHS), a modified Monte Carlo technique, was used in this study. LHS generates a multivariate input structure in which all the variables of interest are varied simultaneously and desired correlations between variables are preserved. LHS has been shown to produce estimates of output distribution functions that are comparable with results of larger random samples

The hidden radiation chemistry in plasma modification and XPS analysis of polymer surfaces

International Nuclear Information System (INIS)

George, G.A.; Le, T.T.; Elms, F.M.; Wood, B.J.

1996-01-01

Full text: The surface modification of polymers using plasma treatments is being widely researched to achieve changes in the surface energetics and consequent wetting and reactivity for a range of applications. These include i) adhesion for polymer bonding and composite material fabrication and ii) biocompatibility of polymers when used as orthopedic implants, catheters and prosthetics. A low pressure rf plasma produces a variety of species from the introduced gas which may react with the surface of a hydrocarbon polymer, such as polyethylene. In the case of 0 2 and H 2 0, these species include oxygen atoms, singlet molecular oxygen and hydroxyl radicals, all of which may oxidise and, depending on their energy, ablate the polymer surface. In order to better understand the reactive species formed both in and downstream from a plasma and the relative contributions of oxidation and ablation, self-assembled monolayers of n-alkane thiols on gold are being used as well characterised substrates for quantitative X-ray photoelectron spectroscopy (XPS). The identification and quantification of oxidised carbon species on plasma treated polymers from broad, asymmetric XPS signals is difficult, so derivatisation is often used to enhance sensitivity and specificity. For example, trifluoroacetic anhydride (TFAA) selectively labels hydroxyl functionality. The surface analysis of a modified polymer surface may be confounded by high energy radiation chemistry which may occur during XPS analysis. Examples include scission of carbon-halogen bonds (as in TFM adducts), decarboxylation and main-chain polyene formation. The extent of free-radical chemistry occurring in polyethylene while undergoing XPS analysis may be seen by both ESR and FT-IR analysis

Risk-oriented analysis of the German prototype fast breeder reactor SNR-300: off-site accident consequence model and results of the study

International Nuclear Information System (INIS)

Bayer, A.; Ehrhardt, J.

1984-01-01

Accident off-site consequence calculations and risk assessments performed for the ''risk oriented analysis'' of the German prototype fast breeder reactor SNR-300 were performed with a modified version of the off-site accident consequence model UFOMOD. The modifications mainly relate to the deposition and resuspension processes, the ingestion model, and the dose factors. Consequence calculations at the site of Kalkar on the Rhine River were performed for 115 weather sequences in 36 wind directions. They were based on seven release categories evaluated for the SNR-300 with two different fueling strategies: plutonium from Magnox reactors only and plutonium from light water reactors and Magnox reactors. In parallel, the corresponding frequencies of occurrence are determined. The following results are generated: 1. complementary cumulative frequency distribution functions for collective fatalities and collective doses 2. expected values of the collective fatalities and collective doses as well as distance-dependent expected values of individual fatality 3. contributions of the different exposure pathways to fatalities with respect to the various organs. For comparison with the risk of a PWR-1300, calculations for the PWR-1300 of the ''German Risk Study'' were repeated with the same modified consequence model. Comparison shows that smaller risks result for the SNR-300. However, the confidence interval bandwidths obtained for the frequencies of the release categories for the SNR-300 are larger than those of the PWR-1300

Long-term psychological consequences of symptomatic pulmonary embolism: a qualitative study.

Science.gov (United States)

Noble, Simon; Lewis, Rhian; Whithers, Jodie; Lewis, Sarah; Bennett, Paul

2014-04-02

To explore the psychological consequences of experiencing symptomatic pulmonary embolism (PE). Qualitative interview-based study using interpretative phenomenological analysis. Outpatients who attended an anticoagulation clinic in a district general hospital. Patients attending an anticoagulation clinic following hospital admission for symptomatic PE were approached to participate. A total of 9 (4 women, 5 men) of 11 patients approached agreed to be interviewed. Participants were aged between 26 and 72 years and had previously experienced a PE between 9 and 60 months (median=26 months, mean=24 months). Audiotaped semistructured qualitative interviews were undertaken to explore participants experiences of having a PE and how it had affected their lives since. Data were transcribed and analysed using interpretative phenomenological analysis to identify emergent themes. Three major themes with associated subthemes were identified. Participants described having a PE as a life-changing experience comprising initial shock, followed by feeling of loss of self, life-changing decisions and behaviour modification. Features of post-traumatic stress disorder (PTSD) were described with flashbacks, hypervigilance and intrusive thoughts being most prevalent. Participants identified several areas of support needed for such patients including easier access to support through information giving and emotional support. Long-term consequences of venous thromboembolism go beyond the physical alone. Patients describe experiencing symptomatic PE to be a life-changing distressing event leading to behaviour modification and in some PTSD. It is likely that earlier psychological intervention may reduce such long-term sequelae.

Axisym finite element code: modifications for pellet-cladding mechanical interaction analysis

International Nuclear Information System (INIS)

Engelman, G.P.

1978-10-01

Local strain concentrations in nuclear fuel rods are known to be potential sites for failure initiation. Assessment of such strain concentrations requires a two-dimensional analysis of stress and strain in both the fuel and the cladding during pellet-cladding mechanical interaction. To provide such a capability in the FRAP (Fuel Rod Analysis Program) codes, the AXISYM code (a small finite element program developed at the Idaho National Engineering Laboratory) was modified to perform a detailed fuel rod deformation analysis. This report describes the modifications which were made to the AXISYM code to adapt it for fuel rod analysis and presents comparisons made between the two-dimensional AXISYM code and the FRACAS-II code. FRACAS-II is the one-dimensional (generalized plane strain) fuel rod mechanical deformation subcode used in the FRAP codes. Predictions of these two codes should be comparable away from the fuel pellet free ends if the state of deformation at the pellet midplane is near that of generalized plane strain. The excellent agreement obtained in these comparisons checks both the correctness of the AXISYM code modifications as well as the validity of the assumption of generalized plane strain upon which the FRACAS-II subcode is based

The radiological assessment system for consequence analysis - RASCAL

International Nuclear Information System (INIS)

Sjoreen, A.L.; Ramsdell, J.V.; Athey, G.F.

1996-01-01

The Radiological Assessment System for Consequence Analysis, Version 2.1 (RASCAL 2.1) has been developed for use during a response to radiological emergencies. The model estimates doses for comparison with U.S. Environmental Protection Agency (EPA) Protective Action Guides (PAGs) and thresholds for acute health effects. RASCAL was designed to be used by U.S. Nuclear Regulatory Commission (NRC) personnel who report to the site of a nuclear accident to conduct an independent evaluation of dose and consequence projections and personnel who conduct training and drills on emergency responses. It allows consideration of the dominant aspects of the source term, transport, dose, and consequences. RASCAL consists of three computational tools: ST-DOSE, FM-DOSE, and DECAY. ST-DOSE computes source term, atmospheric transport, and dose to man from accidental airborne releases of radionuclides. The source-term calculations are appropriate for accidents at U.S. power reactors. FM-DOSE computes doses from environmental concentrations of radionuclides in the air and on the ground. DECAY computes radiological decay and daughter in-growth. RASCAL 2.1 is a DOS application that can be run under Windows 3.1 and 95. RASCAL has been the starting point for other accident consequence models, notably INTERRAS, an international version of RASCAL, and HASCAL, an expansion of RASCAL that will model radiological, biological, and chemical accidents

Fukushima, two years later, modification requirements in nuclear power plants

International Nuclear Information System (INIS)

Sanchez J, J.; Camargo C, R.; Nunez C, A.; Mendoza F, J. E.; Salmeron V, J. A.

2013-10-01

The occurred events in the nuclear power plant of Fukushima Daiichi as consequence of the strong earthquake of 9 grades in the Richter scale and the later tsunami with waves estimated in more than 14 meters high began a series of important questions about the safety of the nuclear power plants in operation and of the new designs. Firstly, have allowed to be questioned on the magnitudes and consequences of the extreme external natural events; that can put in risk the integrity of the safety barriers of a nuclear power plant when being presented in a multiple way. As consequence of the events of the Fukushima Daiichi NPP, the countries with NPPs in operation and /or construction carried out evaluations about their safety operation. They have also realized evaluations about accidents and their impact in the safety, analysis and studies too that have forced to the regulatory bodies to continue a systematic and methodical revision of their procedures and regulations, to identify the possible improvements to the safety in response to the events happened in Japan; everything has taken it to determine the necessity to incorporate additional requirements to the nuclear power plants to mitigate events Beyond the Design Base. Due to Mexico has the nuclear power plant of Laguna Verde, with two units of BWR-5 type with contention Mark III, some the modifications can be applicable to these units to administrate and/or to mitigate the consequences of the possible occurrence of an accident Beyond the Design Base and that could generate a severe accident. In this work an exposition is presented on the modification requirements to confront external natural events Beyond the Design Base, and its application in our country. (Author)

Nature, frequency and determinants of prescription modifications in Dutch community pharmacies

Science.gov (United States)

Buurma, Henk; de Smet, Peter A G M; van den Hoff, Olga P; Egberts, Antoine C G

2001-01-01

modification was also higher (OR = 1.61 [1.33-1.94]). Multivariate analysis revealed that a nonprinted prescription was the strongest independent determinant of prescription modifications (OR = 3.32 [2.87-3.84]), remaining so after adjustment for GP computer link to the pharmacy and for type of prescriber. Conclusions At least 30% of Dutch community pharmacies corrected 2.8 POM prescriptions per pharmacy per working day, which could potentially have had clinical consequences if not altered. If the study sample is representative for The Netherlands, Dutch community pharmacies correct a total of approximately 4400 of these prescriptions per working day. Using computerized systems to generate prescriptions is an important strategy to reduce the incidence of prescription errors. PMID:11453894

An investigation of the relations between fault tree analysis and cause consequence analysis with special reference to a photometry and conductimetry system

International Nuclear Information System (INIS)

Weber, G.

1980-02-01

For an automated photometry and conductimetry system, the relations between cause consequence analysis and fault tree analysis have been investigated. It has been shown how failure combinations of a cause consequence diagram and minimal cuts of a fault tree can be identified. This procedure allows a mutual control of fault tree analysis and cause consequence analysis. From a representation of all failure combinations of the system by means of a matrix we obtain a control of our analysis. Moreover, heuristic rules improving and simplifying the cause consequence analysis can be found. Necessary assumptions for the validity of these rules are discussed. Methodologically, the relation of a fault tree and a cause consequence diagram can be represented (under certain conditions) as a relation of a Boolean function and a binary decision tree. (orig.) 891 HP/orig. 892 MKO [de

Cost-effectiveness analysis of countermeasures using accident consequence assessment models

International Nuclear Information System (INIS)

Alonso, A.; Gallego, E.

1987-01-01

In the event of a large release of radionuclides from a nuclear power plant, protective actions for the population potentially affected must be implemented. Cost-effectiveness analysis will be useful to define the countermeasures and the criteria needed to implement them. This paper shows the application of Accident Consequence Assessment (ACA) models to cost-effectiveness analysis of emergency and long-term countermeasures, making use of the different relationships between dose, contamination levels, affected areas and population distribution, included in such a model. The procedure is illustrated with the new Melcor Accident Consequence Code System (MACCS 1.3), developed at Sandia National Laboratories (USA), for a fixed accident scenario. Different alternative actions are evaluated with regard to their radiological and economical impact, searching for an 'optimum' strategy. (author)

A study on the weather sampling method for probabilistic consequence analysis

International Nuclear Information System (INIS)

Oh, Hae Cheol

1996-02-01

The main task of probabilistic accident consequence analysis model is to predict the radiological situation and to provide a reliable quantitative data base for making decisions on countermeasures. The magnitude of accident consequence is depended on the characteristic of the accident and the weather coincident. In probabilistic accident consequence analysis, it is necessary to repeat the atmospheric dispersion calculation with several hundreds of weather sequences to predict the full distribution of consequences which may occur following a postulated accident release. It is desirable to select a representative sample of weather sequences from a meteorological record which is typical of the area over which the released radionuclides will disperse and which spans a sufficiently long period. The selection process is done by means of sampling techniques from a full year of hourly weather data characteristic of the plant site. In this study, the proposed Weighted importance sampling method selects proportional to the each bin size to closely approximate the true frequency distribution of weather condition at the site. The Weighted importance sampling method results in substantially less sampling uncertainty than the previous technique. The proposed technique can result in improve confidence in risk estimates

Postural habits of young adults and possibilities of modification.

Science.gov (United States)

Nowotny-Czupryna, Olga; Czupryna, Krzysztof; Bąk, Krzysztof; Wróblewska, Ewa; Rottermund, Jerzy

2013-01-01

The aim of the study was to assess postural habits in young, healthy people, identify correlations between postural errors and pain and attempt to modify bad habits. 144 people, aged 18-23 were enrolled. The intervention consisted of 4 stages: Stage 1 - identification of postural habits, description of responses to stress, back pain frequency and intensity (Jackson & Moskowitz); Stage 2 - correction of habitual position with the help of a physiotherapist, briefing about ergonomic everyday behaviours and consequences of continued non-ergonomic behaviours, Stage 3 - follow-up examination: self-assessment of changes, evaluation of the effects of modifications, determination of causes for discontinuing the behaviour modification programme, where applicable; and Stage 4 - final examination, assessment of results. Correlations were sought between inappropriate postural behaviour in various positions and between non-ergonomic postural behaviour and pain location and response to stress. Statistical analysis was carried out with Excel and Statistica v. 7.1. A non-parametric χ(2) test was used at phabit. 3. An attempt to modify non-ergonomic postural behaviours usually results in pain, which may act as a demotivating factor. 4. Discomfort associated with the modification of habitual postural behaviours is reduced after 3-4 months of regular training.

Ion bombardment modification of surfaces

International Nuclear Information System (INIS)

Auciello, O.

1984-01-01

An historical overview of the main advances in the understanding of bombardment-induced surface topography is presented. The implantation and sputtering mechanisms which are relevant to ion bombardment modification of surfaces and consequent structural, electronic and compositional changes are described. Descriptions of plasma and ion-beam sputtering-induced film formation, primary ion-beam deposition, dual beam techniques, cluster of molecule ion-beam deposition, and modification of thin film properties by ion bombardment during deposition are presented. A detailed account is given of the analytical and computational modelling of topography from the viewpoint of first erosion theory. Finally, an account of the possible application and/or importance of textured surfaces in technologies and/or experimental techniques not considered in previous chapters is presented. refs.; figs.; tabs

The BsaHI restriction-modification system: Cloning, sequencing and analysis of conserved motifs

Directory of Open Access Journals (Sweden)

Roberts Richard J

2008-05-01

Full Text Available Abstract Background Restriction and modification enzymes typically recognise short DNA sequences of between two and eight bases in length. Understanding the mechanism of this recognition represents a significant challenge that we begin to address for the BsaHI restriction-modification system, which recognises the six base sequence GRCGYC. Results The DNA sequences of the genes for the BsaHI methyltransferase, bsaHIM, and restriction endonuclease, bsaHIR, have been determined (GenBank accession #EU386360, cloned and expressed in E. coli. Both the restriction endonuclease and methyltransferase enzymes share significant similarity with a group of 6 other enzymes comprising the restriction-modification systems HgiDI and HgiGI and the putative HindVP, NlaCORFDP, NpuORFC228P and SplZORFNP restriction-modification systems. A sequence alignment of these homologues shows that their amino acid sequences are largely conserved and highlights several motifs of interest. We target one such conserved motif, reading SPERRFD, at the C-terminal end of the bsaHIR gene. A mutational analysis of these amino acids indicates that the motif is crucial for enzymatic activity. Sequence alignment of the methyltransferase gene reveals a short motif within the target recognition domain that is conserved among enzymes recognising the same sequences. Thus, this motif may be used as a diagnostic tool to define the recognition sequences of the cytosine C5 methyltransferases. Conclusion We have cloned and sequenced the BsaHI restriction and modification enzymes. We have identified a region of the R. BsaHI enzyme that is crucial for its activity. Analysis of the amino acid sequence of the BsaHI methyltransferase enzyme led us to propose two new motifs that can be used in the diagnosis of the recognition sequence of the cytosine C5-methyltransferases.

Strong Cation Exchange Chromatography in Analysis of Posttranslational Modifications: Innovations and Perspectives

Science.gov (United States)

Edelmann, Mariola J.

2011-01-01

Strong cation exchange (SCX) chromatography has been utilized as an excellent separation technique that can be combined with reversed-phase (RP) chromatography, which is frequently used in peptide mass spectrometry. Although SCX is valuable as the second component of such two-dimensional separation methods, its application goes far beyond efficient fractionation of complex peptide mixtures. Here I describe how SCX facilitates mapping of the protein posttranslational modifications (PTMs), specifically phosphorylation and N-terminal acetylation. The SCX chromatography has been mainly used for enrichment of these two PTMs, but it might also be beneficial for high-throughput analysis of other modifications that alter the net charge of a peptide. PMID:22174558

histoneHMM: Differential analysis of histone modifications with broad genomic footprints

Czech Academy of Sciences Publication Activity Database

Heinig, M.; Colomé-Tatché, M.; Taudt, A.; Rintisch, C.; Schafer, S.; Pravenec, Michal; Hubner, N.; Vingron, M.; Johannes, F.

2015-01-01

Roč. 16, Feb 22 (2015), s. 60 ISSN 1471-2105 R&D Projects: GA MŠk(CZ) 7E10067; GA ČR(CZ) GA13-04420S Institutional support: RVO:67985823 Keywords : ChIP - seq * histone modifications * Hidden Markov model * computational biology * differential analysis Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.435, year: 2015

Prediction of protein modification sites of pyrrolidone carboxylic acid using mRMR feature selection and analysis.

Directory of Open Access Journals (Sweden)

Lu-Lu Zheng

Full Text Available Pyrrolidone carboxylic acid (PCA is formed during a common post-translational modification (PTM of extracellular and multi-pass membrane proteins. In this study, we developed a new predictor to predict the modification sites of PCA based on maximum relevance minimum redundancy (mRMR and incremental feature selection (IFS. We incorporated 727 features that belonged to 7 kinds of protein properties to predict the modification sites, including sequence conservation, residual disorder, amino acid factor, secondary structure and solvent accessibility, gain/loss of amino acid during evolution, propensity of amino acid to be conserved at protein-protein interface and protein surface, and deviation of side chain carbon atom number. Among these 727 features, 244 features were selected by mRMR and IFS as the optimized features for the prediction, with which the prediction model achieved a maximum of MCC of 0.7812. Feature analysis showed that all feature types contributed to the modification process. Further site-specific feature analysis showed that the features derived from PCA's surrounding sites contributed more to the determination of PCA sites than other sites. The detailed feature analysis in this paper might provide important clues for understanding the mechanism of the PCA formation and guide relevant experimental validations.

Exploring oxidative modifications of tyrosine

DEFF Research Database (Denmark)

Houée-Lévin, C; Bobrowski, K; Horakova, L

2015-01-01

residues are oxidised in vivo with impact on cellular homeostasis and redox signalling pathways. A notable example is tyrosine, which can undergo a number of oxidative post-translational modifications to form 3-hydroxy-tyrosine, tyrosine crosslinks, 3-nitrotyrosine and halogenated tyrosine, with different...... effects on cellular functions. Tyrosine oxidation has been studied extensively in vitro, and this has generated detailed information about the molecular mechanisms that may occur in vivo. An important aspect of studying tyrosine oxidation both in vitro and in biological systems is the ability to monitor...... residues modified and the nature of the modification. These approaches have helped understanding of the consequences of tyrosine oxidation in biological systems, especially its effects on cell signalling and cell dysfunction, linking to roles in disease. There is mounting evidence that tyrosine oxidation...

Radiological Consequences Analysis for Abnormal Condition on NPPs 1000 MWe by Using Radcon Model

International Nuclear Information System (INIS)

Pande Mande Udiyani; Sri Kuntjoro

2009-01-01

The operation of NPPs (Nuclear Power Plants) in Indonesia to anticipates rare of energy will generate various challenges, especially about NPPs safety. So installation organizer of nuclear must provide scientific argument to safety NPPs, one of them is by providing document of safety analysis. Calculation of radiological consequences after abnormal condition applies on generic PWR-1000 power reactor. Calculation is done by using program package RadCon (Radiological Consequences Model), with postulate condition is based on DBA (Design Basis Accident). Calculation of dispersion of radionuclide concentration is using PC-COSYMA as input data for RadCon. Simulation for radiological consequences analysis uses by site data sample. Analysis result shows that maximum receiving of internal - externals radiological consequence for short term and long-term below 1 km radius area is below the limit acceptably effective dose for a member of the public as a result of an accident which should not exceed 5 mSv (ICRP 1990). (author)

Assessing economic consequences of radiation accidents

International Nuclear Information System (INIS)

Rowe, M.D.; Lee, J.C.; Grimshaw, C.A.; Kalb, P.D.

1987-01-01

A recent review of existing models and methods for assessing potential consequences of accidents in the high-level radioactive waste (HLW) disposal system identifies economic consequence assessment methods as a weak point. Existing methods have mostly been designed to assess economic consequences of reactor accidents, the possible scale of which can be several orders of magnitude greater than anything possible in the HLW disposal system. There is therefore some question about the applicability of these methods, their assumptions, and their level of detail to assessments of smaller accidents. The US Dept. of Energy funded this study to determine needs for code modifications or model development for assessing economic costs of accidents in the HLW disposal system. The objectives of the study were as follows: (1) review the literature on economic consequences of accidents to determine the availability of assessment methods and data and their applicability to the HLW disposal system before closure. (2) Determine needs for expansion, revision, or adaptation of methods and data for modeling economic consequences of accidents of the scale projected for the disposal system. (3) Gather data that might be useful for the needed revisions for modeling economic impacts on this scale

Unintended Consequences of Wearable Sensor Use in Healthcare

Science.gov (United States)

McCaldin, D.; Wang, K.; Schreier, G.; Lovell, N. H.; Marschollek, M.; Redmond, S. J.

2016-01-01

Summary Objectives As wearable sensors take the consumer market by storm, and medical device manufacturers move to make their devices wireless and appropriate for ambulatory use, this revolution brings with it some unintended consequences, which we aim to discuss in this paper. Methods We discuss some important unintended consequences, both beneficial and unwanted, which relate to: modifications of behavior; creation and use of big data sets; new security vulnerabilities; and unforeseen challenges faced by regulatory authorities, struggling to keep pace with recent innovations. Where possible, we proposed potential solutions to unwanted consequences. Results Intelligent and inclusive design processes may mitigate unintended modifications in behavior. For big data, legislating access to and use of these data will be a legal and political challenge in the years ahead, as we trade the health benefits of wearable sensors against the risk to our privacy. The wireless and personal nature of wearable sensors also exposes them to a number of unique security vulnerabilities. Regulation plays an important role in managing these security risks, but also has the dual responsibility of ensuring that wearable devices are fit for purpose. However, the burden of validating the function and security of medical devices is becoming infeasible for regulators, given the many software apps and wearable sensors entering the market each year, which are only a subset of an even larger ‘internet of things’. Conclusion Wearable sensors may serve to improve wellbeing, but we must be vigilant against the occurrence of unintended consequences. With collaboration between device manufacturers, regulators, and end-users, we balance the risk of unintended consequences occurring against the incredible benefit that wearable sensors promise to bring to the world. PMID:27830234

A tandem regression-outlier analysis of a ligand cellular system for key structural modifications around ligand binding.

Science.gov (United States)

Lin, Ying-Ting

2013-04-30

A tandem technique of hard equipment is often used for the chemical analysis of a single cell to first isolate and then detect the wanted identities. The first part is the separation of wanted chemicals from the bulk of a cell; the second part is the actual detection of the important identities. To identify the key structural modifications around ligand binding, the present study aims to develop a counterpart of tandem technique for cheminformatics. A statistical regression and its outliers act as a computational technique for separation. A PPARγ (peroxisome proliferator-activated receptor gamma) agonist cellular system was subjected to such an investigation. Results show that this tandem regression-outlier analysis, or the prioritization of the context equations tagged with features of the outliers, is an effective regression technique of cheminformatics to detect key structural modifications, as well as their tendency of impact to ligand binding. The key structural modifications around ligand binding are effectively extracted or characterized out of cellular reactions. This is because molecular binding is the paramount factor in such ligand cellular system and key structural modifications around ligand binding are expected to create outliers. Therefore, such outliers can be captured by this tandem regression-outlier analysis.

Use of fire hazard analysis to cost effectively manage facility modifications

Energy Technology Data Exchange (ETDEWEB)

Krueger, K., E-mail: kkruger@plcfire.com [PLC Fire Safety Solutions, Fredericton, NB (Canada); Cronk, R., E-mail: rcronk@plcfire.com [PLC Fire Safety Solutions, Mississauga, ON (Canada)

2014-07-01

In Canada, licenced Nuclear power facilities, or facilities that process, handle or store nuclear material are required by the Canadian Nuclear Safety Commission to have a change control process in place. These processes are in place to avoid facility modifications that could result in an increase in fire hazards, or degradation of fire protection systems. Change control processes can have a significant impact on budgets associated with plant modifications. A Fire Hazard Analysis (FHA) is also a regulatory requirement for licenced facilities in Canada. An FHA is an extensive evaluation of a facility's construction, nuclear safety systems, fire hazards, and fire protection features. This paper is being presented to outline how computer based data management software can help organize facilities' fire safety information, manage this information, and reduce the costs associated with preparation of FHAs as well as facilities' change control processes. (author)

Radiological consequence analysis of a repository for radioactive waste

International Nuclear Information System (INIS)

Fitzpatrick, J.; Buchheim, B.; Hoop, F.J.

1982-01-01

One of the methods under consideration for the disposal of radioactive wastes is emplacement in a repository within deep, continental formations. This paper presents the experience gained in developing a methodology to make an assessment of the radiological consequences both for normal operation and for possible accident situations for a specific repository design in a salt dome at Gorleben in Germany , designed to accommodate all categories of radioactive waste. Radionuclide release scenarios were derived from a systematic analysis of the facility design and proposed operational procedure. Where necessary simple numerical models for such topics as direct radiation exposure from waste containers, release and transport of radionuclides, radiolysis, heat transfer, creep and impact were developed to give a first estimate of the radiological consequences due to radionuclide releases. (author)

An environmental-economic assessment of genetic modification of agricultural crops

NARCIS (Netherlands)

van den Bergh, J.C.J.M.; Holley, J.M.

2002-01-01

The advantages and disadvantages of genetic modification of organisms in agriculture are reviewed. These relate to the environment, human health, socio-economic effects, population growth, and differential consequences for developed and developing countries. An overall evaluation requires that

Tank waste compositions and atmospheric dispersion coefficients for use in accelerated safety analysis consequence assessments. Revision 1

International Nuclear Information System (INIS)

Savino, A.V.

1995-11-01

This topical report contains technical support information used to determine accident consequences for the Tank Farms Accelerated Safety Analysis (ASA) Interim Chapter 3, Hazard and Accident Analysis: Potential for Releases and Required Mitigation and Prevention and the Tank Waste Remediation System (TWRS) environmental impact statement (EIS) accident consequence report. It does not determine accident consequences or describe specific accident scenarios, but instead provides generic information used to calculate radiological and toxic chemical consequences for postulated tank farms accident releases

The effect of halloysite modification combined with in situ matrix modifications on the structure and properties of polypropylene/halloysite nanocomposites

Directory of Open Access Journals (Sweden)

V. Khunova

2013-05-01

Full Text Available The effect of various modifications/intercalations of halloysite and the combination of these modifications with in situ PP matrix modification was investigated with respect to the structure and properties of the polypropylene/halloysite nanocomposites. Hexadecyl-tri-methyl-ammonium-bromide (HEDA, 3-aminopropyltrimethoxysilane and urea were used as the intercalators/modifiers. The best intercalation was found for urea, although an unexpected insignificant impact on the mechanical properties also resulted as a consequence of the urea polarity and the significant decrease in PP crystallinity. However, the simultaneous application of 4,4!-diphenylmethylene dimaleinimide (DBMI brought about an increase in the mechanical behavior by increasing the halloysite/PP affinity as a result of in situ matrix modification. This effect was further supported by coupling between the PP and halloysite (HNT in the system containing urea-intercalated HNT. This can be explained by the occurrence of a urea-supported reaction between the imide ring of DBMI and the OH groups of the HNT, which resulted in the best mechanical behaviors achieved in this study.

Identification of cofactor and herbicide binding domains in acetolactate synthase by bromopyruvate modification

International Nuclear Information System (INIS)

Van Dyk, D.E.; Schloss, J.V.

1987-01-01

Bromopyruvate is an affinity label for acetolactate synthase isozyme II from Salmonella typhimurium (ALSII). The concentration of bromopyruvate giving half-maximal inactivation is 0.1 mM, and the maximal rate of inactivation is 0.56 hr -1 . Inactivation with [ 14 C]bromopyruvate is associated with the incorporation of 4 molecules of reagent per active site lost. Two cysteinyl residues are modified extremely rapidly, with no loss of enzymatic activity, as judged by quenching the reaction with thiol after its initial phase. Inactivation is a consequence of the additional two moles of reagent incorporated per mole of protomer. The additional incorporation is divided between one major and two minor sites of modification. Substantial protection against inactivation is afforded by FAD, with virtually complete protection provided by a mixture of FAD and thiamine pyrophosphate (TPP). The major site of modification, protected by FAD, is cysteinyl residue number67, based upon amino acid sequence analysis of the purified tryptic peptide that encompasses this site. The remaining site of modification, protected by TPP, is associated with cysteinyl residue number44. Both sites of modification are afforded protection by the sulfonylurea herbicide sulfometuron methyl (SM). Although inactivation by bromopyruvate exhibits rate saturation, indicating binding as a prerequisite to inactivation, neither pyruvate nor α-ketobutyrate prevent modification of the enzyme by bromopyruvate. Thus, it would appear that the bromopyruvate binding site is not the site normally occupied by substrate

Greenhouse effect: analysis, incertitudes, consequences

International Nuclear Information System (INIS)

Perrier, A.

1991-01-01

A general presentation of climatic changes due to greenhouse effect with their consequences is analysed. After a schematic description of this effect a simplified atmospheric model (box model) is proposed. This model integrates the main feedback effects and quantifies them. The effects of astronomic and atmospheric factors on climatic changes are analyzed and compared with classical paleoclimatic results. This study shows the need of good global modelization to evaluate long term quantification of climatic greenhouse effects according to the main time lag of the several biospheric boxes. An overview of biologic and agronomic consequences is given to promote new research subjects and to orientate protecting and conservative biospheric actions [fr

Some consequences of a non-commutative space-time structure

International Nuclear Information System (INIS)

Vilela Mendes, R.

2005-01-01

The existence of a fundamental length (or fundamental time) has been conjectured in many contexts. Here we discuss some consequences of a fundamental constant of this type, which emerges as a consequence of deformation-stability considerations leading to a non-commutative space-time structure. This mathematically well defined structure is sufficiently constrained to allow for unambiguous experimental predictions. In particular we discuss the phase-space volume modifications and their relevance for the calculation of the Greisen-Zatsepin-Kuz'min sphere. The (small) corrections to the spectrum of the Coulomb problem are also computed. (orig.)

Uncertainty Analysis of Consequence Management (CM) Data Products.

Energy Technology Data Exchange (ETDEWEB)

Hunt, Brian D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Eckert-Gallup, Aubrey Celia [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Cochran, Lainy Dromgoole [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Kraus, Terrence D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Fournier, Sean Donovan [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Allen, Mark B. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Schetnan, Richard Reed [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Simpson, Matthew D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Okada, Colin E. [Remote Sensing Lab. (RSL), Nellis AFB, Las Vegas, NV (United States); Bingham, Avery A. [Remote Sensing Lab. (RSL), Nellis AFB, Las Vegas, NV (United States)

2018-01-01

The goal of this project is to develop and execute methods for characterizing uncertainty in data products that are deve loped and distributed by the DOE Consequence Management (CM) Program. A global approach to this problem is necessary because multiple sources of error and uncertainty from across the CM skill sets contribute to the ultimate p roduction of CM data products. This report presents the methods used to develop a probabilistic framework to characterize this uncertainty and provides results for an uncertainty analysis for a study scenario analyzed using this framework.

PERSPECTIVES ON A DOE CONSEQUENCE INPUTS FOR ACCIDENT ANALYSIS APPLICATIONS

International Nuclear Information System (INIS)

O'Kula, K.R.; Thoman, D.C.; Lowrie, J.; Keller, A.

2008-01-01

Department of Energy (DOE) accident analysis for establishing the required control sets for nuclear facility safety applies a series of simplifying, reasonably conservative assumptions regarding inputs and methodologies for quantifying dose consequences. Most of the analytical practices are conservative, have a technical basis, and are based on regulatory precedent. However, others are judgmental and based on older understanding of phenomenology. The latter type of practices can be found in modeling hypothetical releases into the atmosphere and the subsequent exposure. Often the judgments applied are not based on current technical understanding but on work that has been superseded. The objective of this paper is to review the technical basis for the major inputs and assumptions in the quantification of consequence estimates supporting DOE accident analysis, and to identify those that could be reassessed in light of current understanding of atmospheric dispersion and radiological exposure. Inputs and assumptions of interest include: Meteorological data basis; Breathing rate; and Inhalation dose conversion factor. A simple dose calculation is provided to show the relative difference achieved by improving the technical bases

The Use of Chemical Modification of Polymer Waste for Obtaining Polymer Flocculants

Institute of Scientific and Technical Information of China (English)

W.W.Sulkowski; K.Nowak; A.Sulkowska; A.Wolin; ska; S.Malanka; W.M.Baldur; D.Pentak

2007-01-01

1 Results Chemical modification of polymer plastic wastes to useful products can be one of the way of effective waste plastics management (chemical recycling). Chemical modification of polymers and polymer plastic wastes can yield products with suitable physical and chemical properties. In consequence they can be used as polyelectrolytes[1]. The variety of pollutants, universality of various water and sewage treatment technologies, introduction of new water quality improved technologies have caused a gr...

Continuous creation of matter and Tolman's modification of Einstein field equations

International Nuclear Information System (INIS)

Turkowski, P.

1985-01-01

A modification of Einstein field equations which permits processes of creation or destruction of energy, suggested by Richard C. Tolman, is presented. Brief comment is given and the cosmological consequences of the hypothesis are examined. 8 refs. (author)

Microscopic mechanism of amino silicone oil modification and modification effect with different amino group contents based on molecular dynamics simulation

Science.gov (United States)

He, Liping; Li, Wenjun; Chen, Dachuan; Yuan, Jianmin; Lu, Gang; Zhou, Dianwu

2018-05-01

The microscopic mechanism of amino silicone oil (ASO) modification of natural fiber was investigated for the first time using molecular dynamics (MD) simulation at the atomic and molecular levels. The MD simulation results indicated that the ASO molecular interacted with the cellulose molecular within the natural fiber, mainly by intermolecular forces of Nsbnd Hsbnd O and Osbnd Hsbnd N hydrogen bonds and the molecular chain of ASO absorbed onto the natural fiber in a selective orientation, i.e., the hydrophobic alkyl groups (sbnd CnH2n+1) project outward and the polar amino groups (sbnd NH2) point to the surface of natural fiber. Consequently, the ASO modification changed the surface characteristic of natural fiber from hydrophilic to hydrophobic. Furthermore, the modification effects of the ASO modification layer with different amino group contents (m:n ratio) were also evaluated in this study by calculating the binding energy between the ASO modifier and natural fiber, and the cohesive energy density and free volume of the ASO modification layer. The results showed that the binding energy reached a maximum when the m:n ratio of ASO was of 8:4, suggesting that a good bonding strength was achieved at this m:n ratio. It was also found that the cohesive energy density enhanced with the increase in the amino group content, and the higher the cohesive energy density, the easier the formation of the ASO modification layer. However, the fraction free volume decreased with the increase in the amino group content. This is good for improving the water-proof property of natural fiber. The present work can provide an effective method for predicting the modification effects and designing the optimized m:n ratio of ASO modification.

Sensitive analysis and modifications to reflood-related constitutive models of RELAP5

International Nuclear Information System (INIS)

Li Dong; Liu Xiaojing; Yang Yanhua

2014-01-01

Previous system code calculation reveals that the cladding temperature is underestimated and quench front appears too early during reflood process. To find out the parameters shows important effect on the results, sensitive analysis is performed on parameters of constitutive physical models. Based on the phenomenological and theoretical analysis, four parameters are selected: wall to vapor film boiling heat transfer coefficient, wall to liquid film boiling heat transfer coefficient, dry wall interfacial friction coefficient and minimum droplet diameter. In order to improve the reflood simulation ability of RELAP5 code, the film boiling heat transfer model and dry wall interfacial friction model which are corresponding models of those influential parameters are studied. Modifications have been made and installed into RELAP5 code. Six tests of FEBA are simulated by RELAP5 to study the predictability of reflood-related physical models. A dispersed flow film boiling heat transfer (DFFB) model is applied when void fraction is above 0.9. And a factor is multiplied to the post-CHF drag coefficient to fit the experiment better. Finally, the six FEBA tests are calculated again so as to assess the modifications. Better results are obtained which prove the advantage of the modified models. (author)

Niagara pumping generation station inundation mapping and consequence analysis with ArcGIS and Mike 21

Energy Technology Data Exchange (ETDEWEB)

Grover, Patrick; Khayer, Yasmin; Naumov, Aleksey [4DM Inc., Toronto, (Canada); Zhang, Yibing [Ontario Power Generation, Toronto, (Canada)

2010-07-01

Inundation mapping is a key factor of Ontario Power Generation's dam safety program. It is the basis for determining the hazard potential classification of the dam by modelling the consequences of a hypothetical dam failure. This paper presented the project for updating the inundation mapping and consequence analysis study at the Niagara Pump generating station (PGS) reservoir. A complete hydrotechnical assessment of the Niagara PGS reservoir was conducted. The modelling of various breach scenarios was carried out using the 2-D hydrodynamic software MIKE 21 in order to provide the hydraulic data necessary for producing the inundation maps. Updated EPRP maps were produced and a consequence analysis was performed which confirmed the existing hazard classification. The ArcGIS system was used as the underlying framework for all major components of the project. It was found that the use of GIS technologies improve the efficiency of both modelling and analysis.

Consequence Analysis of Release from KN-18 Cask during a Severe Transportation Accident

International Nuclear Information System (INIS)

Lim, Heoksoon; Bhang, Giin; Na, Janghwan; Ban, Jaeha; Kim, Myungsu

2015-01-01

Korea Hydro and Nuclear Power (KHNP) has launched a project entitled 'Development of APR1400 Physical Protection System Design' and conducting a new conceptual physical protection system(PPS) design. One of mayor contents is consequence analysis for spent nuclear fuel cask. Proper design of physical protection system for facilities and storage and transformation involving nuclear and radioactive material requires the quantification of potential consequence from prescribed sabotage and theft scenarios in order to properly understand the level of PPS needed for specific facilities and materials. An important aspect of the regulation of the nuclear industry is assessing the risk to the public and the environment from a release of radioactive material produced by accidental or intentional scenarios. This paper describes the consequence analysis methodology, structural analysis for KN-18 cask and results of release from the cask during a severe transportation accident. Accident during spent fuel cask transportation was numerically calculated for KN-18, and showed the integrity of the fuel assemblies and cask itself was unharmed on a scenario that is comparable to state of art NRC research. Even assumption of leakage as a size of 1 x 10''2 mm''2 does not exceed for a certain criteria at any distance

Consequence Analysis of Release from KN-18 Cask during a Severe Transportation Accident

Energy Technology Data Exchange (ETDEWEB)

Lim, Heoksoon; Bhang, Giin; Na, Janghwan; Ban, Jaeha; Kim, Myungsu [KAERI, Daejeon (Korea, Republic of)

2015-05-15

Korea Hydro and Nuclear Power (KHNP) has launched a project entitled 'Development of APR1400 Physical Protection System Design' and conducting a new conceptual physical protection system(PPS) design. One of mayor contents is consequence analysis for spent nuclear fuel cask. Proper design of physical protection system for facilities and storage and transformation involving nuclear and radioactive material requires the quantification of potential consequence from prescribed sabotage and theft scenarios in order to properly understand the level of PPS needed for specific facilities and materials. An important aspect of the regulation of the nuclear industry is assessing the risk to the public and the environment from a release of radioactive material produced by accidental or intentional scenarios. This paper describes the consequence analysis methodology, structural analysis for KN-18 cask and results of release from the cask during a severe transportation accident. Accident during spent fuel cask transportation was numerically calculated for KN-18, and showed the integrity of the fuel assemblies and cask itself was unharmed on a scenario that is comparable to state of art NRC research. Even assumption of leakage as a size of 1 x 10''2 mm''2 does not exceed for a certain criteria at any distance.

Consequences for central nervous system functional state of exposure to ionizing radiation modification with antioxidants

International Nuclear Information System (INIS)

Tukalenko, Je.V.; Varets'kij, V.V.; Rakochyi, O.G.; Dmyitryijeva, Yi.R.

2004-01-01

Aim: to estimate the pattern of ionizing radiation effects modification by antioxidants using central nervous system functional state indices. The studies were carried out using 84 rats. Beta-carotene and alpha-tocopherol were found to significantly improve conditioned activity indices level of the animals exposed to ionizing radiation and emotional-pain stress

Computational and statistical methods for high-throughput analysis of post-translational modifications of proteins

DEFF Research Database (Denmark)

Schwämmle, Veit; Braga, Thiago Verano; Roepstorff, Peter

2015-01-01

The investigation of post-translational modifications (PTMs) represents one of the main research focuses for the study of protein function and cell signaling. Mass spectrometry instrumentation with increasing sensitivity improved protocols for PTM enrichment and recently established pipelines...... for high-throughput experiments allow large-scale identification and quantification of several PTM types. This review addresses the concurrently emerging challenges for the computational analysis of the resulting data and presents PTM-centered approaches for spectra identification, statistical analysis...

Modifications in the Teach-C computer code for convection analysis-two-dimensional transient diffusion

International Nuclear Information System (INIS)

Sampaio, P.A.B. de.

1987-08-01

Some modifications in Teach-C computer program to analyse the heat conduction with convective heat transport are presented. The utilization of the program to solve a convective - diffusion problem is studied and the results are compared with an analysis of the same problem, in steady - state conditions, by finite element method [pt

Modifications to Replacement Costs System

International Nuclear Information System (INIS)

Godec, M.

1989-01-01

The purpose of this memorandum is to document the improvements and modifications made to the Replacement Costs of Crude Oil (REPCO) Supply Analysis System. While some of this work was performed under our previous support contract to DOE/ASFE, we are presenting all modifications and improvements are presented here for completeness. The memo primarily documents revisions made to the Lower-48 Onshore Model. Revisions and modifications made to other components and models in the REPCO system which are documented elsewhere are only highlighted in this memo. Generally, the modifications made to the Lower-48 Onshore Model reflect changes that have occurred in domestic drilling, oil field costs, and reserves since 1982, the date of the most recent available data used for the original Replacement Costs report, published in 1985

Evaluation system for the analysis of the radiological consequences (RASCAL)

International Nuclear Information System (INIS)

Miguel Martinez, M. J. de

2011-01-01

The code currently employed by the Spanish Nuclear power is the IRDAM (Interactive Rapid Dose Assessment Model). This code will now be replaced by the RASCAL (Radiological Assessment System for Consequence Analysis) version 4.0. This is a significant improvement in dose calculation for escapes to the atmosphere for radioactive emergencies. The main objective is to highlight the most significant changes introduced in the RASCAL when performing these dose estimates.

Development of web-based Off-Site Consequence Analysis Program (OSCAP) for extending ILRT intervals and its application

International Nuclear Information System (INIS)

Jeon, Ho-Jun; Hwang, Seok-Won; Oh, Ji-Yong

2012-01-01

Highlights: ► We develop web-based offsite consequence analysis program based on MACCS II code. ► The program has an automatic processing module to make the main input data. ► It is effective in conducting risk assessments according to extending ILRT intervals. ► Even a beginner can perform offsite consequence analysis with the program. - Abstract: For an offsite consequence analysis, MELCOR Accident Consequence Code System (MACCS) II code is widely used as a tool. In this study, the algorithm of web-based Off-Site Consequence Analysis Program (OSCAP) using the MACCS II code was developed for an integrated leak rate test (ILRT) interval extension and Level 3 probabilistic safety assessment (PSA), and verification and validation (V and V) of the program was performed. The main input data of the MACCS II code are meteorological data, population distribution data and source term data. However, it requires lots of time and efforts to generate the main input data for an offsite consequence analysis using the MACCS II code. For example, the meteorological data are collected from each nuclear power site in real time, but the formats of the raw data collected are different from each other as a site. To reduce efforts and time for risk assessments, the web-based OSCAP has an automatic processing module which converts the format of the raw data collected from each site in Korea to the input data format of the MACCS II code. The program also provides an automatic function of converting the latest population data from Statistics Korea, the National Statistical Office, to the population distribution input data format of the MACCS II code. In case of the source term data, the program includes the release fraction of each source term category resulting from Modular Accident Analysis Program (MAAP) code analysis and the core inventory data from ORIGEN code analysis. These analysis results of each plant in Korea are stored in a database module of the web-based OSCAP, so a

Surface modification and endothelialization of biomaterials as potential scaffolds for vascular tissue engineering applications.

Science.gov (United States)

Ren, Xiangkui; Feng, Yakai; Guo, Jintang; Wang, Haixia; Li, Qian; Yang, Jing; Hao, Xuefang; Lv, Juan; Ma, Nan; Li, Wenzhong

2015-08-07

Surface modification and endothelialization of vascular biomaterials are common approaches that are used to both resist the nonspecific adhesion of proteins and improve the hemocompatibility and long-term patency of artificial vascular grafts. Surface modification of vascular grafts using hydrophilic poly(ethylene glycol), zwitterionic polymers, heparin or other bioactive molecules can efficiently enhance hemocompatibility, and consequently prevent thrombosis on artificial vascular grafts. However, these modified surfaces may be excessively hydrophilic, which limits initial vascular endothelial cell adhesion and formation of a confluent endothelial lining. Therefore, the improvement of endothelialization on these grafts by chemical modification with specific peptides and genes is now arousing more and more interest. Several active peptides, such as RGD, CAG, REDV and YIGSR, can be specifically recognized by endothelial cells. Consequently, graft surfaces that are modified by these peptides can exhibit targeting selectivity for the adhesion of endothelial cells, and genes can be delivered by targeting carriers to specific tissues to enhance the promotion and regeneration of blood vessels. These methods could effectively accelerate selective endothelial cell recruitment and functional endothelialization. In this review, recent developments in the surface modification and endothelialization of biomaterials in vascular tissue engineering are summarized. Both gene engineering and targeting ligand immobilization are promising methods to improve the clinical outcome of artificial vascular grafts.

Consequence analysis of IWTS metal water reactions (Fauske and Associates report 99-35)

International Nuclear Information System (INIS)

DUNCAN, D.R.

1999-01-01

The report describes the consequences of postulated thermally unstable conditions in the IWTS knock out pot. The consequence analysis shows that both the knock out pot and particulate bed will stay intact, and that releases will be minor. Reaction rate limitations prevent knock out pot pressure and/or temperature from even approaching values that would threaten structural integrity. Source term calculations based on a particle bed with a homogeneous mixture of metal and oxide particles yield a release above the K Basin pool of about 12 grams

Sensitivity Analysis of Weather Variables on Offsite Consequence Analysis Tools in South Korea and the United States

Directory of Open Access Journals (Sweden)

Min-Uk Kim

2018-05-01

Full Text Available We studied sensitive weather variables for consequence analysis, in the case of chemical leaks on the user side of offsite consequence analysis (OCA tools. We used OCA tools Korea Offsite Risk Assessment (KORA and Areal Location of Hazardous Atmospheres (ALOHA in South Korea and the United States, respectively. The chemicals used for this analysis were 28% ammonia (NH3, 35% hydrogen chloride (HCl, 50% hydrofluoric acid (HF, and 69% nitric acid (HNO3. The accident scenarios were based on leakage accidents in storage tanks. The weather variables were air temperature, wind speed, humidity, and atmospheric stability. Sensitivity analysis was performed using the Statistical Package for the Social Sciences (SPSS program for dummy regression analysis. Sensitivity analysis showed that impact distance was not sensitive to humidity. Impact distance was most sensitive to atmospheric stability, and was also more sensitive to air temperature than wind speed, according to both the KORA and ALOHA tools. Moreover, the weather variables were more sensitive in rural conditions than in urban conditions, with the ALOHA tool being more influenced by weather variables than the KORA tool. Therefore, if using the ALOHA tool instead of the KORA tool in rural conditions, users should be careful not to cause any differences in impact distance due to input errors of weather variables, with the most sensitive one being atmospheric stability.

Sensitivity Analysis of Weather Variables on Offsite Consequence Analysis Tools in South Korea and the United States.

Science.gov (United States)

Kim, Min-Uk; Moon, Kyong Whan; Sohn, Jong-Ryeul; Byeon, Sang-Hoon

2018-05-18

We studied sensitive weather variables for consequence analysis, in the case of chemical leaks on the user side of offsite consequence analysis (OCA) tools. We used OCA tools Korea Offsite Risk Assessment (KORA) and Areal Location of Hazardous Atmospheres (ALOHA) in South Korea and the United States, respectively. The chemicals used for this analysis were 28% ammonia (NH₃), 35% hydrogen chloride (HCl), 50% hydrofluoric acid (HF), and 69% nitric acid (HNO₃). The accident scenarios were based on leakage accidents in storage tanks. The weather variables were air temperature, wind speed, humidity, and atmospheric stability. Sensitivity analysis was performed using the Statistical Package for the Social Sciences (SPSS) program for dummy regression analysis. Sensitivity analysis showed that impact distance was not sensitive to humidity. Impact distance was most sensitive to atmospheric stability, and was also more sensitive to air temperature than wind speed, according to both the KORA and ALOHA tools. Moreover, the weather variables were more sensitive in rural conditions than in urban conditions, with the ALOHA tool being more influenced by weather variables than the KORA tool. Therefore, if using the ALOHA tool instead of the KORA tool in rural conditions, users should be careful not to cause any differences in impact distance due to input errors of weather variables, with the most sensitive one being atmospheric stability.

Probabilistic accident consequence uncertainty analysis: Dispersion and deposition uncertainty assessment, main report

International Nuclear Information System (INIS)

Harper, F.T.; Young, M.L.; Miller, L.A.; Hora, S.C.; Lui, C.H.; Goossens, L.H.J.; Cooke, R.M.; Paesler-Sauer, J.; Helton, J.C.

1995-01-01

The development of two new probabilistic accident consequence codes, MACCS and COSYMA, was completed in 1990. These codes estimate the risks presented by nuclear installations based on postulated frequencies and magnitudes of potential accidents. In 1991, the US Nuclear Regulatory Commission (NRC) and the Commission of the European Communities (CEC) began a joint uncertainty analysis of the two codes. The ultimate objective of the joint effort was to develop credible and traceable uncertainty distributions for the input variables of the codes. Expert elicitation was identified as the best technology available for developing a library of uncertainty distributions for the selected consequence parameters. The study was formulated jointly and was limited to the current code models and to physical quantities that could be measured in experiments. Experts developed their distributions independently. To validate the distributions generated for the wet deposition input variables, samples were taken from these distributions and propagated through the wet deposition code model. Resulting distributions closely replicated the aggregated elicited wet deposition distributions. To validate the distributions generated for the dispersion code input variables, samples from the distributions and propagated through the Gaussian plume model (GPM) implemented in the MACCS and COSYMA codes. Project teams from the NRC and CEC cooperated successfully to develop and implement a unified process for the elaboration of uncertainty distributions on consequence code input parameters. Formal expert judgment elicitation proved valuable for synthesizing the best available information. Distributions on measurable atmospheric dispersion and deposition parameters were successfully elicited from experts involved in the many phenomenological areas of consequence analysis. This volume is the first of a three-volume document describing the project

COMPARISON OF CONSEQUENCE ANALYSIS RESULTS FROM TWO METHODS OF PROCESSING SITE METEOROLOGICAL DATA

International Nuclear Information System (INIS)

, D

2007-01-01

Consequence analysis to support documented safety analysis requires the use of one or more years of representative meteorological data for atmospheric transport and dispersion calculations. At minimum, the needed meteorological data for most atmospheric transport and dispersion models consist of hourly samples of wind speed and atmospheric stability class. Atmospheric stability is inferred from measured and/or observed meteorological data. Several methods exist to convert measured and observed meteorological data into atmospheric stability class data. In this paper, one year of meteorological data from a western Department of Energy (DOE) site is processed to determine atmospheric stability class using two methods. The method that is prescribed by the U.S. Nuclear Regulatory Commission (NRC) for supporting licensing of nuclear power plants makes use of measurements of vertical temperature difference to determine atmospheric stability. Another method that is preferred by the U.S. Environmental Protection Agency (EPA) relies upon measurements of incoming solar radiation, vertical temperature gradient, and wind speed. Consequences are calculated and compared using the two sets of processed meteorological data from these two methods as input data into the MELCOR Accident Consequence Code System 2 (MACCS2) code

Swift heavy ion induced modification of aliphatic polymers

International Nuclear Information System (INIS)

Hossain, Umme Habiba

2015-01-01

In this thesis, the high energy heavy ion induced modification of aliphatic polymers is studied. Two polymer groups, namely polyvinyl polymers (PVF, PVAc, PVA and PMMA) and fluoropolymers (PVDF, ETFE, PFA and FEP) were used in this work. Polyvinyl polymers were investigated since they will be used as insulating materials in the superconducting magnets of the new ion accelerators of the planned International Facility for Antiproton and Ion Research (FAIR) at the GSI Helmholtz-Centre of Heavy Ion Research (GSI) in Darmstadt. In order to study ion-beam induced degradation, all polymer foils were irradiated at the GSI linear accelerator UNILAC using several projectiles (U, Au, Sm, Xe) and experimentation sites (beam lines X0 and M3) over a large fluence regime (1 x 10 10 - 5 x 10 12 ions/cm 2 ). Five independent techniques, namely infrared (FT-IR) and ultraviolet-visible (UV-Vis) spectroscopy, residual gas analysis (RGA), thermal gravimetric analysis (TGA), and mass loss analysis (ML), were used to analyze the irradiated samples. FT-IR spectroscopy revealed that ion irradiation led to the decrease of characteristic band intensities showing the general degradation of the polymers, with scission of side groups and the main backbone. As a consequence of the structural modification, new bands appeared. UV-Vis transmission analysis showed an absorption edge shift from the ultraviolet region towards the visible region indicating double bond and conjugated double bond formation. On-line massspectrometric residual gas analysis showed the release of small gaseous fragment molecules. TGA analysis gave evidence of a changed thermal stability. With ML analysis, the considerable mass loss was quantified. The results of the five complementary analytical methods show how heavy ion irradiation changes the molecular structure of the polymers. Molecular degradation mechanisms are postulated. The amount of radiation damage is found to be sensitive to the used type of ionic species. While

Functional consequences of piceatannol binding to glyceraldehyde-3-phosphate dehydrogenase.

Science.gov (United States)

Gerszon, Joanna; Serafin, Eligiusz; Buczkowski, Adam; Michlewska, Sylwia; Bielnicki, Jakub Antoni; Rodacka, Aleksandra

2018-01-01

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is one of the key redox-sensitive proteins whose activity is largely affected by oxidative modifications at its highly reactive cysteine residue in the enzyme's active site (Cys149). Prolonged exposure to oxidative stress may cause, inter alia, the formation of intermolecular disulfide bonds leading to accumulation of GAPDH aggregates and ultimately to cell death. Recently these anomalies have been linked with the pathogenesis of Alzheimer's disease. Novel evidences indicate that low molecular compounds may be effective inhibitors potentially preventing the GAPDH translocation to the nucleus, and inhibiting or slowing down its aggregation and oligomerization. Therefore, we decided to establish the ability of naturally occurring compound, piceatannol, to interact with GAPDH and to reveal its effect on functional properties and selected parameters of the dehydrogenase structure. The obtained data revealed that piceatannol binds to GAPDH. The ITC analysis indicated that one molecule of the tetrameric enzyme may bind up to 8 molecules of polyphenol (7.3 ± 0.9). Potential binding sites of piceatannol to the GAPDH molecule were analyzed using the Ligand Fit algorithm. Conducted analysis detected 11 ligand binding positions. We indicated that piceatannol decreases GAPDH activity. Detailed analysis allowed us to presume that this effect is due to piceatannol ability to assemble a covalent binding with nucleophilic cysteine residue (Cys149) which is directly involved in the catalytic reaction. Consequently, our studies strongly indicate that piceatannol would be an exceptional inhibitor thanks to its ability to break the aforementioned pathologic disulfide linkage, and therefore to inhibit GAPDH aggregation. We demonstrated that by binding with GAPDH piceatannol blocks cysteine residue and counteracts its oxidative modifications, that induce oligomerization and GAPDH aggregation.

The concept of validation of numerical models for consequence analysis

International Nuclear Information System (INIS)

Borg, Audun; Paulsen Husted, Bjarne; Njå, Ove

2014-01-01

Numerical models such as computational fluid dynamics (CFD) models are increasingly used in life safety studies and other types of analyses to calculate the effects of fire and explosions. The validity of these models is usually established by benchmark testing. This is done to quantitatively measure the agreement between the predictions provided by the model and the real world represented by observations in experiments. This approach assumes that all variables in the real world relevant for the specific study are adequately measured in the experiments and in the predictions made by the model. In this paper the various definitions of validation for CFD models used for hazard prediction are investigated to assess their implication for consequence analysis in a design phase. In other words, how is uncertainty in the prediction of future events reflected in the validation process? The sources of uncertainty are viewed from the perspective of the safety engineer. An example of the use of a CFD model is included to illustrate the assumptions the analyst must make and how these affect the prediction made by the model. The assessments presented in this paper are based on a review of standards and best practice guides for CFD modeling and the documentation from two existing CFD programs. Our main thrust has been to assess how validation work is performed and communicated in practice. We conclude that the concept of validation adopted for numerical models is adequate in terms of model performance. However, it does not address the main sources of uncertainty from the perspective of the safety engineer. Uncertainty in the input quantities describing future events, which are determined by the model user, outweighs the inaccuracies in the model as reported in validation studies. - Highlights: • Examine the basic concept of validation applied to models for consequence analysis. • Review standards and guides for validation of numerical models. • Comparison of the validation

Undermining and Strengthening Social Networks through Network Modification

Science.gov (United States)

Mellon, Jonathan; Yoder, Jordan; Evans, Daniel

2016-10-01

Social networks have well documented effects at the individual and aggregate level. Consequently it is often useful to understand how an attempt to influence a network will change its structure and consequently achieve other goals. We develop a framework for network modification that allows for arbitrary objective functions, types of modification (e.g. edge weight addition, edge weight removal, node removal, and covariate value change), and recovery mechanisms (i.e. how a network responds to interventions). The framework outlined in this paper helps both to situate the existing work on network interventions but also opens up many new possibilities for intervening in networks. In particular use two case studies to highlight the potential impact of empirically calibrating the objective function and network recovery mechanisms as well as showing how interventions beyond node removal can be optimised. First, we simulate an optimal removal of nodes from the Noordin terrorist network in order to reduce the expected number of attacks (based on empirically predicting the terrorist collaboration network from multiple types of network ties). Second, we simulate optimally strengthening ties within entrepreneurial ecosystems in six developing countries. In both cases we estimate ERGM models to simulate how a network will endogenously evolve after intervention.

[Genotoxic modification of nucleic acid bases and biological consequences of it. Review and prospects of experimental and computational investigations

Science.gov (United States)

Poltev, V. I.; Bruskov, V. I.; Shuliupina, N. V.; Rein, R.; Shibata, M.; Ornstein, R.; Miller, J.

1993-01-01

The review is presented of experimental and computational data on the influence of genotoxic modification of bases (deamination, alkylation, oxidation) on the structure and biological functioning of nucleic acids. Pathways are discussed for the influence of modification on coding properties of bases, on possible errors of nucleic acid biosynthesis, and on configurations of nucleotide mispairs. The atomic structure of nucleic acid fragments with modified bases and the role of base damages in mutagenesis and carcinogenesis are considered.

Modification-specific proteomics: strategies for characterization of post-translational modifications using enrichment techniques

DEFF Research Database (Denmark)

Zhao, Yingming; Jensen, Ole N

2009-01-01

More than 300 different types of protein post-translational modifications (PTMs) have been described, many of which are known to have pivotal roles in cellular physiology and disease. Nevertheless, only a handful of PTMs have been extensively investigated at the proteome level. Knowledge of protein...... substrates and their PTM sites is key to dissection of PTM-mediated cellular processes. The past several years have seen a tremendous progress in developing MS-based proteomics technologies for global PTM analysis, including numerous studies of yeast and other microbes. Modification-specific enrichment...

Meta-analysis of the antecedent and consequent constructs of materialism

OpenAIRE

Fernando de Oliveira Santini; Wagner Júnior Ladeira; Cláudio Hoffmann Sampaio; Clécio Falcão Araújo

2017-01-01

Purpose – Materialism has been gaining ground in the academic field, especially from the 1980s on, given the relevance of understanding sentiments connected to possessing and acquiring goods. Thus, this meta-analysis was carried out to assess the antecedents and consequents of materialism. Design/methodology/approach – Based on a systematic review, we gathered a total 77 articles that examined those aspects, generating 99 effects-sizes and a cumulative sample of 40,288 studied individuals...

Gender Affirmation and Body Modification Among Transgender Persons in Bogotá, Colombia.

Science.gov (United States)

Aguayo-Romero, Rodrigo A; Reisen, Carol A; Zea, Maria Cecilia; Bianchi, Fernanda T; Poppen, Paul J

This paper examined structural, social, and personal characteristics that shape the processes of gender affirmation and body modification among transgender persons (assigned male at birth) in Bogotá, Colombia. Qualitative data from life-history interviews (N=14) and a focus group (N=11) explored research questions concerning the ways in which the internal psychological and external contextual processes influence individuals' decisions and behaviors concerning hormonal treatment, injections, or surgery. Research questions concerning practices and consequences of treatment performed without medical supervision were addressed through qualitative data, as well as quantitative data from 58 transgender participants. Findings indicated variation in ways participants conceptualized gender (e.g., binary or fluid), but an increased feminine presentation was a strong personal desire expressed by many and often encouraged by romantic partners and transgender friends. Transgender individuals within participants' social networks were frequently instrumental not only in providing information about hormones and contouring injections, but also in carrying out procedures-sometimes with negative consequences. Body modification procedures occurred primarily outside the health care system, due to limited access to or awareness of medical care, societal stigma, social norms within the transgender community, and personal decision-making. Public health approaches to protect the health of transgender persons undergoing body modification were suggested.

Application of residual modification approach in seasonal ARIMA for electricity demand forecasting: A case study of China

International Nuclear Information System (INIS)

Wang Yuanyuan; Wang Jianzhou; Zhao Ge; Dong Yao

2012-01-01

Electricity demand forecasting could prove to be a useful policy tool for decision-makers; thus, accurate forecasting of electricity demand is valuable in allowing both power generators and consumers to make their plans. Although a seasonal ARIMA model is widely used in electricity demand analysis and is a high-precision approach for seasonal data forecasting, errors are unavoidable in the forecasting process. Consequently, a significant research goal is to further improve forecasting precision. To help people in the electricity sectors make more sensible decisions, this study proposes residual modification models to improve the precision of seasonal ARIMA for electricity demand forecasting. In this study, PSO optimal Fourier method, seasonal ARIMA model and combined models of PSO optimal Fourier method with seasonal ARIMA are applied in the Northwest electricity grid of China to correct the forecasting results of seasonal ARIMA. The modification models forecasting of the electricity demand appears to be more workable than that of the single seasonal ARIMA. The results indicate that the prediction accuracy of the three residual modification models is higher than the single seasonal ARIMA model and that the combined model is the most satisfactory of the three models. - Highlights: ► Three residual modification models are proposed to improve the precision of seasonal ARIMA. ► Accurate electricity demand forecast is helpful for a power production sector to come to a correct and reasonable decision. ► The results conclude that the residual modification approaches could enhance the prediction accuracy of seasonal ARIMA. ► The modification models could be applied to forecast electricity demand.

Probabilistic accident consequence uncertainty analysis -- Late health effects uncertain assessment. Volume 2: Appendices

Energy Technology Data Exchange (ETDEWEB)

Little, M.P.; Muirhead, C.R. [National Radiological Protection Board (United Kingdom); Goossens, L.H.J.; Kraan, B.C.P.; Cooke, R.M. [Delft Univ. of Technology (Netherlands); Harper, F.T. [Sandia National Labs., Albuquerque, NM (United States); Hora, S.C. [Univ. of Hawaii, Hilo, HI (United States)

1997-12-01

The development of two new probabilistic accident consequence codes, MACCS and COSYMA, was completed in 1990. These codes estimate the consequence from the accidental releases of radiological material from hypothesized accidents at nuclear installations. In 1991, the US Nuclear Regulatory Commission and the Commission of the European Communities began cosponsoring a joint uncertainty analysis of the two codes. The ultimate objective of this joint effort was to systematically develop credible and traceable uncertainty distributions for the respective code input variables. A formal expert judgment elicitation and evaluation process was identified as the best technology available for developing a library of uncertainty distributions for these consequence parameters. This report focuses on the results of the study to develop distribution for variables related to the MACCS and COSYMA late health effects models. This volume contains appendices that include (1) a summary of the MACCS and COSYMA consequence codes, (2) the elicitation questionnaires and case structures, (3) the rationales and results for the expert panel on late health effects, (4) short biographies of the experts, and (5) the aggregated results of their responses.

Probabilistic accident consequence uncertainty analysis -- Early health effects uncertainty assessment. Volume 2: Appendices

Energy Technology Data Exchange (ETDEWEB)

Haskin, F.E. [Univ. of New Mexico, Albuquerque, NM (United States); Harper, F.T. [Sandia National Labs., Albuquerque, NM (United States); Goossens, L.H.J.; Kraan, B.C.P. [Delft Univ. of Technology (Netherlands)

1997-12-01

The development of two new probabilistic accident consequence codes, MACCS and COSYMA, was completed in 1990. These codes estimate the consequence from the accidental releases of radiological material from hypothesized accidents at nuclear installations. In 1991, the US Nuclear Regulatory Commission and the Commission of the European Communities began cosponsoring a joint uncertainty analysis of the two codes. The ultimate objective of this joint effort was to systematically develop credible and traceable uncertainty distributions for the respective code input variables. A formal expert judgment elicitation and evaluation process was identified as the best technology available for developing a library of uncertainty distributions for these consequence parameters. This report focuses on the results of the study to develop distribution for variables related to the MACCS and COSYMA early health effects models. This volume contains appendices that include (1) a summary of the MACCS and COSYMA consequence codes, (2) the elicitation questionnaires and case structures, (3) the rationales and results for the panel on early health effects, (4) short biographies of the experts, and (5) the aggregated results of their responses.

Probabilistic accident consequence uncertainty analysis -- Uncertainty assessment for internal dosimetry. Volume 2: Appendices

Energy Technology Data Exchange (ETDEWEB)

Goossens, L.H.J.; Kraan, B.C.P.; Cooke, R.M. [Delft Univ. of Technology (Netherlands); Harrison, J.D. [National Radiological Protection Board (United Kingdom); Harper, F.T. [Sandia National Labs., Albuquerque, NM (United States); Hora, S.C. [Univ. of Hawaii, Hilo, HI (United States)

1998-04-01

The development of two new probabilistic accident consequence codes, MACCS and COSYMA, was completed in 1990. These codes estimate the consequence from the accidental releases of radiological material from hypothesized accidents at nuclear installations. In 1991, the US Nuclear Regulatory Commission and the Commission of the European Communities began cosponsoring a joint uncertainty analysis of the two codes. The ultimate objective of this joint effort was to systematically develop credible and traceable uncertainty distributions for the respective code input variables. A formal expert judgment elicitation and evaluation process was identified as the best technology available for developing a library of uncertainty distributions for these consequence parameters. This report focuses on the results of the study to develop distribution for variables related to the MACCS and COSYMA internal dosimetry models. This volume contains appendices that include (1) a summary of the MACCS and COSYMA consequence codes, (2) the elicitation questionnaires and case structures, (3) the rationales and results for the panel on internal dosimetry, (4) short biographies of the experts, and (5) the aggregated results of their responses.

Atmospheric dispersion and the radiological consequences of normal airborne effluents from a nuclear power plant

International Nuclear Information System (INIS)

Fang, D.; Yang, L.; Sun, C.Z.

1995-01-01

The relationship between the consequences of the normal exhaust of radioactive materials in air from nuclear power plants and atmospheric dispersion is studied. Because the source terms of the exhaust from a nuclear power plant are relatively low and their radiological consequences are far less than the corresponding authoritative limits, the atmospheric dispersion models, their various modifications, and selections of relevant parameters have few effects on those consequences. In the environmental assessment and siting, the emphasis should not be placed on the consequence evaluation of routine exhaust of nuclear power plants, and the calculation of consequences of the exhaust and atmospheric field measurements should be appropriately, simplified. 12 refs., 5 figs., 7 tabs

Methodological guidelines for developing accident modification functions

DEFF Research Database (Denmark)

Elvik, Rune

2015-01-01

This paper proposes methodological guidelines for developing accident modification functions. An accident modification function is a mathematical function describing systematic variation in the effects of road safety measures. The paper describes ten guidelines. An example is given of how to use...... limitations in developing accident modification functions are the small number of good evaluation studies and the often huge variation in estimates of effect. It is therefore still not possible to develop accident modification functions for very many road safety measures. © 2015 Elsevier Ltd. All rights...... the guidelines. The importance of exploratory analysis and an iterative approach in developing accident modification functions is stressed. The example shows that strict compliance with all the guidelines may be difficult, but represents a level of stringency that should be strived for. Currently the main...

Analysis of radiological consequences in a typical BWR with a mark-II containment

International Nuclear Information System (INIS)

Funayama, Kyoko; Kajimoto, Mitsuhiro

2003-01-01

INS/NUPEC in Japan has been carrying out the Level 3 PSA program. In the program, the MACCS2 code has been extensively applied to analyze radiological consequences for typical BWR and PWR plants in Japan. The present study deals with analysis of effects of the AMs, which were implemented by industries, on radiological consequence for a typical BWR with a Mark-II containment. In the present study, source terms and their frequencies of source terms were used based on results of Level 2 PSA taking into account AM countermeasures. Radiological consequences were presented with dose risks (Sv/ry), which were multiplied doses (Sv) by containment damage frequencies (/ry), and timing of radionuclides release to the environment. The results of the present study indicated that the dose risks became negligible in most cases taking AM countermeasures and evacuations. (author)

Accident consequence calculations for project W-058 safety analysis

International Nuclear Information System (INIS)

Van Keuren, J.C.

1997-01-01

Accident consequence analyses have been performed for Project W-058, the Replacement Cross Site Transfer System. using the assumption and analysis techniques developed for the Tank Remediation Waste system Basis for Interim Operation. most potential accident involving the FISTS are bounded by the TWRS BIO analysis. However, the spray leak and pool leak scenarios require revised analyses since the RCSTS design utilizes larger diameter pipe and higher pressures than those analyzed in the TWRS BIO. Also the volume of diversion box and vent station are larger than that assumed for the valve pits in the TWRS BIO, which effects results of sprays or spills into the pits. the revised analysis for the spray leak is presented in Section 2, for the above ground spill in Section 3, for the presented in Section 2, for the above ground spill in Section 3, for the subsurface spill forming a pool in Section 4, and for the subsurface pool remaining subsurface in Section 5. The conclusion from these sections are summarized below

Epigenomic landscape modified by histone modification correlated with activation of IGF2 gene

Science.gov (United States)

The links of histone post-translational modifications and chromatin structure to cell cycle progression, DNA replication, and overall chromosome functions are very clear. The modulation of genome expression as a consequence of chromatin structural changes is most likely a basic mechanism. The epige...

Sleep modifications in acute transient global amnesia.

Science.gov (United States)

Della Marca, Giacomo; Mazza, Marianna; Losurdo, Anna; Testani, Elisa; Broccolini, Aldobrando; Frisullo, Giovanni; Marano, Giuseppe; Morosetti, Roberta; Pilato, Fabio; Profice, Paolo; Vollono, Catello; Di Lazzaro, Vincenzo

2013-09-15

Transient global amnesia (TGA) is a temporary memory loss characterized by an abrupt onset of antero-grade and retrograde amnesia, totally reversible. Since sleep plays a major role in memory consolidation, and in the storage of memory-related traces into the brain cortex, the aims of the present study were: (1) to evaluate changes in sleep macro-structure in TGA; (2) to assess modifications in sleep micro-structure in TGA, with particular reference to the arousal EEG and to cyclic alternating pattern (CAP); (3) to compare sleep parameters in TGA patients with a control group of patients with acute ischemic events ("minor stroke" or transient ischemic attack [TIA]) clinically and neuroradiologically "similar" to the TGA. TGA GROUP: 17 patients, (8 men and 9 women, 60.2 ± 12.5 years). Stroke or TIA (SoT) group: 17 patients hospitalized in the Stroke Unit for recent onset of minor stroke or TIA with hemispheric localization; healthy controls (HC) group: 17 healthy volunteers, matched for age and sex. Patients and controls underwent full-night polysomnography. In the multivariate analysis (conditions TGA, SoT, and HC) a significant effect of the condition was observed for sleep efficiency index, number of awakenings longer 1 min, REM latency, CAP time, and CAP rate. TGA and SoT differed only for CAP time and CAP rate, which were lower in the TGA group. Microstructural modification associated with tga could be consequent to: (1) hippocampal dysfunction and memory impairment; (2) impairment of arousal-related structures (in particular, cholinergic pathways); (3) emotional distress.

The application of the health effects models to the severe accident consequence analysis of nuclear power plants

International Nuclear Information System (INIS)

Yang Ling; Yeung, M.R.

1998-01-01

Health Effect Model (HEM) is an important model used in the analysis of severe accidents consequence of the Nuclear Power Plants (NPP). The accuracy of HEM affects the reliability of the assessment for the accidents consequences, and furthermore, the effectiveness of the emergency countermeasures taken for the health protection of the public around the NPPs. Based on the NUREG/CR4214 series reports, the paper sets appropriate parameters for HEM by studying both early and late HEMs used for domestic NPP accident consequence analysis. In the study, the Guangdong Daya Bay NPP is chosen as an example study to calculate the health risk of the Hong Kong population caused by Daya Bay NPP

Modeling maize response to climate modification in Hungary

OpenAIRE

Angela Anda

2006-01-01

Modeling provides a tool for a better understanding of the modified plant behaviour that results from various climatic differences. The present study provides new information about the physiological processes in maize (Zea mays L.) in response to climatic changes. The aim was to help local farmers adapt to climate modifications in Hungary and mitigate the future consequences of these changes. A simulation model was applied to estimate the possible feedback on crop properties and elevated CO2....

Accident consequence calculations for project W-058 safety analysis

International Nuclear Information System (INIS)

Van Keuren, J.C.

1997-01-01

This document describes the calculations performed to determine the accident consequences for the W-058 safety analysis. Project W-058 is the replacement cross site transfer system (RCSTS), which is designed to transort liquid waste between the 200 W and 200 E areas. Calculations for RCSTS safety analyses used the same methods as the calculations for the Tank Waste Remediation System (TWRS) Basis for Interim Operation (BIO) and its supporting calculation notes. Revised analyses were performed for the spray and pool leak accidents since the RCSTS flows and pressures differ from those assumed in the TWRS BIO. Revision 1 of the document incorporates review comments

Materials analysis by ion backscattering and channeling. Materials modification by ion irradiation and implementation

International Nuclear Information System (INIS)

Meyer, O.

1984-08-01

A description will be given of the basic processes occuring during ion implantation and ion beam analyses. The usefulness of the backscattering and channeling technique is demonstrated by a discussion of the applications to thin film analysis, studies of diffusion and reactions in thin films, lattice location investigations, disorder analysis and surface studies. Ion implantation is a valuable research tool in metallurgy. The process operates very far from equilibrium conditions and thus will influence near surface properties in a unique way. The observed modifications are related to special microscopic structures which will be considered in detail. (orig.) [de

Meta-analysis of the antecedent and consequent constructs of materialism

Directory of Open Access Journals (Sweden)

Fernando de Oliveira Santini

2017-10-01

Full Text Available Purpose – Materialism has been gaining ground in the academic field, especially from the 1980s on, given the relevance of understanding sentiments connected to possessing and acquiring goods. Thus, this meta-analysis was carried out to assess the antecedents and consequents of materialism. Design/methodology/approach – Based on a systematic review, we gathered a total 77 articles that examined those aspects, generating 99 effects-sizes and a cumulative sample of 40,288 studied individuals. Findings – The antecedents of materialism that showed a significant relationship with this construct were: perceived hedonic value, interpersonal influence, life satisfaction, and income. As for the consequents, we observed significance for purchase intention, impulsive buying, compulsive buying, conspicuous consumption, status consumption, and consumer involvement. Regarding the moderating effect, we observed that small samples produce greater effects. Furthermore, for the relationship between materialism and purchase intention, there are stronger effects for surveys conducted in Western countries. Originality/value – Based on the methodology applied in this study, we expected a solid and generalizable contribution regarding construct materialism.

Biochemical systems approaches for the analysis of histone modification readout.

Science.gov (United States)

Soldi, Monica; Bremang, Michael; Bonaldi, Tiziana

2014-08-01

Chromatin is the macromolecular nucleoprotein complex that governs the organization of genetic material in the nucleus of eukaryotic cells. In chromatin, DNA is packed with histone proteins into nucleosomes. Core histones are prototypes of hyper-modified proteins, being decorated by a large number of site-specific reversible and irreversible post-translational modifications (PTMs), which contribute to the maintenance and modulation of chromatin plasticity, gene activation, and a variety of other biological processes and disease states. The observations of the variety, frequency and co-occurrence of histone modifications in distinct patterns at specific genomic loci have led to the idea that hPTMs can create a molecular barcode, read by effector proteins that translate it into a specific transcriptional state, or process, on the underlying DNA. However, despite the fact that this histone-code hypothesis was proposed more than 10 years ago, the molecular details of its working mechanisms are only partially characterized. In particular, two questions deserve specific investigation: how the different modifications associate and synergize into patterns and how these PTM configurations are read and translated by multi-protein complexes into a specific functional outcome on the genome. Mass spectrometry (MS) has emerged as a versatile tool to investigate chromatin biology, useful for both identifying and validating hPTMs, and to dissect the molecular determinants of histone modification readout systems. We review here the MS techniques and the proteomics methods that have been developed to address these fundamental questions in epigenetics research, emphasizing approaches based on the proteomic dissection of distinct native chromatin regions, with a critical evaluation of their present challenges and future potential. This article is part of a Special Issue entitled: Molecular mechanisms of histone modification function. Copyright © 2014 Elsevier B.V. All rights reserved.

Statutory Instrument No. 2056, The Nuclear Installations Act 1965 etc. (Repeals and Modifications) Regulations 1974

International Nuclear Information System (INIS)

1975-01-01

These Regulations contain repeals and modifications of provisions of the Nuclear Installations Act 1965 and a modification of the Nuclear Installations (Dangerous Occurrences) Regulations 1965. They are made in consequence of the establishment on 1st January 1975 of the Health and Safety Executive and the coming into operation on that date of provisions of the Health and Safety at Work etc. Act 1974 which supersede or affect provisions of the 1965 Act and the 1965 Regulations. (NEA) [fr

Functional consequences of piceatannol binding to glyceraldehyde-3-phosphate dehydrogenase.

Directory of Open Access Journals (Sweden)

Joanna Gerszon

Full Text Available Glyceraldehyde-3-phosphate dehydrogenase (GAPDH is one of the key redox-sensitive proteins whose activity is largely affected by oxidative modifications at its highly reactive cysteine residue in the enzyme's active site (Cys149. Prolonged exposure to oxidative stress may cause, inter alia, the formation of intermolecular disulfide bonds leading to accumulation of GAPDH aggregates and ultimately to cell death. Recently these anomalies have been linked with the pathogenesis of Alzheimer's disease. Novel evidences indicate that low molecular compounds may be effective inhibitors potentially preventing the GAPDH translocation to the nucleus, and inhibiting or slowing down its aggregation and oligomerization. Therefore, we decided to establish the ability of naturally occurring compound, piceatannol, to interact with GAPDH and to reveal its effect on functional properties and selected parameters of the dehydrogenase structure. The obtained data revealed that piceatannol binds to GAPDH. The ITC analysis indicated that one molecule of the tetrameric enzyme may bind up to 8 molecules of polyphenol (7.3 ± 0.9. Potential binding sites of piceatannol to the GAPDH molecule were analyzed using the Ligand Fit algorithm. Conducted analysis detected 11 ligand binding positions. We indicated that piceatannol decreases GAPDH activity. Detailed analysis allowed us to presume that this effect is due to piceatannol ability to assemble a covalent binding with nucleophilic cysteine residue (Cys149 which is directly involved in the catalytic reaction. Consequently, our studies strongly indicate that piceatannol would be an exceptional inhibitor thanks to its ability to break the aforementioned pathologic disulfide linkage, and therefore to inhibit GAPDH aggregation. We demonstrated that by binding with GAPDH piceatannol blocks cysteine residue and counteracts its oxidative modifications, that induce oligomerization and GAPDH aggregation.

Nitric Oxide-Mediated Posttranslational Modifications: Impacts at the Synapse

Directory of Open Access Journals (Sweden)

Sophie A. Bradley

2016-01-01

Full Text Available Nitric oxide (NO is an important gasotransmitter molecule that is involved in numerous physiological processes throughout the nervous system. In addition to its involvement in physiological plasticity processes (long-term potentiation, LTP; long-term depression, LTD which can include NMDAR-mediated calcium-dependent activation of neuronal nitric oxide synthase (nNOS, new insights into physiological and pathological consequences of nitrergic signalling have recently emerged. In addition to the canonical cGMP-mediated signalling, NO is also implicated in numerous pathways involving posttranslational modifications. In this review we discuss the multiple effects of S-nitrosylation and 3-nitrotyrosination on proteins with potential modulation of function but limit the analyses to signalling involved in synaptic transmission and vesicular release. Here, crucial proteins which mediate synaptic transmission can undergo posttranslational modifications with either pre- or postsynaptic origin. During normal brain function, both pathways serve as important cellular signalling cascades that modulate a diverse array of physiological processes, including synaptic plasticity, transcriptional activity, and neuronal survival. In contrast, evidence suggests that aging and disease can induce nitrosative stress via excessive NO production. Consequently, uncontrolled S-nitrosylation/3-nitrotyrosination can occur and represent pathological features that contribute to the onset and progression of various neurodegenerative diseases, including Parkinson’s, Alzheimer’s, and Huntington’s.

Greenhouse effect increase and its consequences

International Nuclear Information System (INIS)

Royer, J.F.; Mahfouf, J.F.

1992-01-01

Observations on the evolution of the atmospheric composition concerning trace gases (CO 2 , CH 4 , NO 2 , CFC) are first described. Then the fundamental role played by these gases in the radiative equilibrium of the earth through the greenhouse effect is examined. Numerical models have been developed to forecast the consequences of an increase of the greenhouse effect. The importance of the feedback mechanism, where the oceans and the clouds have the central part, but not well estimated by the models, is explained. Climatic changes generally accepted are reviewed. In conclusion the need to improve our knowledge of the global climatic system to forecast future modifications is underlined

Modification of MELCOR for severe accident analysis of candidate accident tolerant cladding materials

Energy Technology Data Exchange (ETDEWEB)

Merrill, Brad J., E-mail: brad.merrill@inl.gov; Bragg-Sitton, Shannon M., E-mail: shannon.bragg-sitton@inl.gov; Humrickhouse, Paul W., E-mail: paul.humrickhouse@inl.gov

2017-04-15

Highlights: • Accident tolerant fuels (ATF) systems are currently under development for LWRs. • Many performance analysis tools are specifically developed for UO{sub 2}–Zr alloy fuel. • Modifications were made to the MELCOR code for candidate ATF cladding. • Preliminary analysis results for SiC and FeCrAl cladding concepts are presented. - Abstract: A number of materials are currently under development as candidate accident tolerant fuel and cladding for application in the current fleet of commercial light water reactors (LWRs). The safe, reliable and economic operation of the nation’s nuclear power reactor fleet has always been a top priority for the nuclear industry. Continual improvement of technology, including advanced materials and nuclear fuels, remains central to the industry’s success. Enhancing the accident tolerance of light water reactors became a topic of serious discussion following the 2011 Great East Japan Earthquake, resulting tsunami, and subsequent damage to the Fukushima Daiichi nuclear power plant complex. The overall goal for the development of accident tolerant fuel (ATF) systems for LWRs is to identify alternative fuel system technologies to further enhance the safety, competitiveness, and economics of commercial nuclear power. Designed for use in the current fleet of commercial LWRs, or in reactor concepts with design certifications (GEN-III+), to achieve their goal enhanced ATF must endure loss of active cooling in the reactor core for a considerably longer period of time than the current fuel system, while maintaining or improving performance during normal operation. Many available nuclear fuel performance analysis tools are specifically developed for the current UO{sub 2}–Zirconium alloy fuel system. The MELCOR severe-accident analysis code, under development at the Sandia National Laboratory in New Mexico (SNL-NM) for the US Nuclear Regulatory Commission (NRC), is one of these tools. This paper describes modifications

Modeling polyvinyl chloride Plasma Modification by Neural Networks

Science.gov (United States)

Wang, Changquan

2018-03-01

Neural networks model were constructed to analyze the connection between dielectric barrier discharge parameters and surface properties of material. The experiment data were generated from polyvinyl chloride plasma modification by using uniform design. Discharge voltage, discharge gas gap and treatment time were as neural network input layer parameters. The measured values of contact angle were as the output layer parameters. A nonlinear mathematical model of the surface modification for polyvinyl chloride was developed based upon the neural networks. The optimum model parameters were obtained by the simulation evaluation and error analysis. The results of the optimal model show that the predicted value is very close to the actual test value. The prediction model obtained here are useful for discharge plasma surface modification analysis.

Motivations for body piercings and tattoos - the role of sexual abuse and the frequency of body modifications.

Science.gov (United States)

Stirn, Aglaja; Oddo, Silvia; Peregrinova, Ludmila; Philipp, Swetlana; Hinz, Andreas

2011-12-30

Though the popularity of body modification increases, psychosocial data about practitioners of body piercing and tattooing are few and controversial. Most studies used semi-structured interviews and relatively small sample sizes. The aim of this study was to explore psychosocial background information (motivation, sexual abuse) for body modification practises based on a sufficiently large sample. A core group of 432 subjects with body piercings and/or tattoos (readers of a specialised magazine on body modification; mean age: 28 years) was investigated in this study using a 55-item questionnaire. The mean number of body modifications (piercings and tattoos) was nine. Participants with a history of sexual abuse and high users with more than 10 body modifications differed from those without these features with respect to several motivations and consequences of body modification. Participants with sexual abuse often stated that they wanted to overcome certain experiences, and high users were characterised by the feeling of an addiction to continue body modification. Clinicians should include questions on body modifications and their motives in anamnestic schedules. Copyright © 2011 Elsevier Ltd. All rights reserved.

Statistics and analysis of the inspection report´s modification rate

Directory of Open Access Journals (Sweden)

Xing HE

2014-08-01

Full Text Available Objective: Accordingto the statistics and regulatory inspection reports modification rate, incorporated in the hospital quality control target,together withthe strictly control and management makethe inspection results change rate up to the hospital quality management requirements. Methods: Counted upevery kind of biochemical items which were monitored by machine 7180 in the biochemical laboratory from April to October 2013, and strengthen the inspector´s sense of responsibility by the modification rate of timely rectification. Results: Every kind of biochemical items which were monitored by the machine 7180 including 62022 persons in the biochemical laboratory from April to October 2013, 896 persons´ inspection results were altered before printing ,which was 1.45 percent ;75 persons´ inspection results were altered by upper administrator after printing, which was 0.12 percent of the total and 8.37 percent of the altered people. Conclusion: Our inspection report modification rate decreased from 27.77 percent in April to 1.88 percent in October ,the percentage decreased obviously. It proved that the PDCA model was successful in inspection report modification rate of Lis in our hospital, which achieved our quality management target.

Covalent Surface Modifications of Carbon Nanotubes.

Energy Technology Data Exchange (ETDEWEB)

Pavia Sanders, Adriana [Sandia National Lab. (SNL-CA), Livermore, CA (United States); O' Bryan, Greg [Sandia National Lab. (SNL-CA), Livermore, CA (United States)

2017-07-01

A report meant to document the chemistries investigated by the author for covalent surface modification of CNTs. Oxidation, cycloaddition, and radical reactions were explored to determine their success at covalently altering the CNT surface. Characterization through infrared spectroscopy, Raman spectroscopy, and thermo gravimetric analysis was performed in order to determine the success of the chemistries employed. This report is not exhaustive and was performed for CNT surface modification exploration as it pertains to the "Next Gen" project.

Proteomic analysis of post translational modifications in cyanobacteria.

Science.gov (United States)

Xiong, Qian; Chen, Zhuo; Ge, Feng

2016-02-16

Cyanobacteria are a diverse group of Gram-negative bacteria and the only prokaryotes capable of oxygenic photosynthesis. Recently, cyanobacteria have attracted great interest due to their crucial roles in global carbon and nitrogen cycles and their ability to produce clean and renewable biofuels. To survive in various environmental conditions, cyanobacteria have developed a complex signal transduction network to sense environmental signals and implement adaptive changes. The post-translational modifications (PTMs) systems play important regulatory roles in the signaling networks of cyanobacteria. The systematic investigation of PTMs could contribute to the comprehensive description of protein species and to elucidate potential biological roles of each protein species in cyanobacteria. Although the proteomic studies of PTMs carried out in cyanobacteria were limited, these data have provided clues to elucidate their sophisticated sensing mechanisms that contribute to their evolutionary and ecological success. This review aims to summarize the current status of PTM studies and recent publications regarding PTM proteomics in cyanobacteria, and discuss the novel developments and applications for the analysis of PTMs in cyanobacteria. Challenges, opportunities and future perspectives in the proteomics studies of PTMs in cyanobacteria are also discussed. Copyright © 2015 Elsevier B.V. All rights reserved.

DYNAMIC HYBRIDS UNDER SOLVENCY II: RISK ANALYSIS AND MODIFICATION POSSIBILITIES

Directory of Open Access Journals (Sweden)

Christian Maier

2017-06-01

Full Text Available In this study, we investigate the new and standardized European system of supervisory called Solvency II. In essence, asymmetric distribution of information between policyholder and insurer triggered this new regulation which aims at better protecting policyholders. Its three-pillar model is about to challenge both, insurers as well as policyholders. The first pillar includes quantitative aspects, the second pillar contains qualitative aspects and the third pillar comprises market transparency and reporting obligations. Underwriting risks, the default risk of a bank and market risks can be identified for the dynamic hybrid. Solvency II covers all these risks in the first pillar and insurers shall deposit sufficient risk-bearing capital. In our analysis, we first identify the dynamic hybrid specific risks under the Solvency II regime und then develop product modifications to reduce this risk.

Modifications of the Weibull distribution: A review

International Nuclear Information System (INIS)

Almalki, Saad J.; Nadarajah, Saralees

2014-01-01

It is well known that the Weibull distribution is the most popular and the most widely used distribution in reliability and in analysis of lifetime data. Unfortunately, its hazard function cannot exhibit non-monotonic shapes like the bathtub shape or the unimodal shape. Since 1958, the Weibull distribution has been modified by many researchers to allow for non-monotonic hazard functions. This paper gives an extensive review of some discrete and continuous versions of the modifications of the Weibull distribution. - Highlights: • A comprehensive review of known discrete modifications and generalizations of the Weibull distribution. • A comprehensive review of known continuous modifications and generalizations of the Weibull distribution. • Over 110 references on modifications/generalizations of the Weibull distribution. • More than 55% of the cited references appeared in the last 5 years

An uncertainty analysis using the NRPB accident consequence code Marc

International Nuclear Information System (INIS)

Jones, J.A.; Crick, M.J.; Simmonds, J.R.

1991-01-01

This paper describes an uncertainty analysis of MARC calculations of the consequences of accidental releases of radioactive materials to atmosphere. A total of 98 parameters describing the transfer of material through the environment to man, the doses received, and the health effects resulting from these doses, was considered. The uncertainties in the numbers of early and late health effects, numbers of people affected by countermeasures, the amounts of food restricted and the economic costs of the accident were estimated. This paper concentrates on the results for early death and fatal cancer for a large hypothetical release from a PWR

Analysis and modification of blue sapphires from Rwanda by ion beam techniques

International Nuclear Information System (INIS)

Bootkul, D.; Chaiwai, C.; Tippawan, U.; Wanthanachaisaeng, B.; Intarasiri, S.

2015-01-01

Highlights: • Ion beam analysis is an effective method for detecting trace elements. • Ion beam treatment is able to improve optical and color appearances of the blue sapphire from Rwanda. • These alternative methods can be extended to jewelry industry for large scale application. - Abstract: Blue sapphire is categorised in a corundum (Al_2O_3) group. The gems of this group are always amazed by their beauties and thus having high value. In this study, blue sapphires from Rwanda, recently came to Thai gemstone industry, are chosen for investigations. On one hand, we have applied Particle Induced X-ray Emission (PIXE), which is a highly sensitive and precise analytical technique that can be used to identify and quantify trace elements, for chemical analysis of the sapphires. Here we have found that the major element of blue sapphires from Rwanda is Al with trace elements such as Fe, Ti, Cr, Ga and Mg as are commonly found in normal blue sapphire. On the other hand, we have applied low and medium ion implantations for color improvement of the sapphire. It seems that a high amount of energy transferring during cascade collisions have altered the gems properties. We have clearly seen that the blue color of the sapphires have been intensified after nitrogen ion bombardment. In addition, the gems were also having more transparent and luster. The UV–Vis–NIR measurement detected the modification of their absorption properties, implying of the blue color increasing. Here the mechanism of these modifications is postulated and reported. In any point of view, the bombardment by using nitrogen ion beam is a promising technique for quality improvement of the blue sapphire from Rwanda.

The surface modification of polystyrene

International Nuclear Information System (INIS)

Tremlett, C.

2000-03-01

Polymers have ideal bulk properties for many applications. However, adhesion to many polymers is poor without surface pretreatment. This can result, for example, in peeling paint and printing, adhesive joint failure and bio-incompatibility. In applications such as painting, printing, adhesive bonding and biocompatibility, various cleaning or surface chemical modifications may be employed. A commodity polymer where pretreatment is sometimes needed is polystyrene. This project investigated, in detail, the effects of a novel method of modification namely mediated electrochemical oxidation (MEO), as a mode of surface modification on polystyrene and a comparison was made with other polymers. The resulting modification was investigated using a range of surface analysis techniques to obtain complementary information. These included, X-ray photoelectron spectroscopy, contact angles, static secondary ion mass spectrometry, atomic force microscopy, chemical derivatization, scanning electron microscopy, attenuated total reflection Fourier Transform infrared spectroscopy and composite lap shear joint testing. It has been shown that MEO modifies the surface of polystyrene introduced oxygen mainly as hydroxyl groups, and a small number of carbonyl groups, that are positioned only on the backbone hydrocarbon chain. This modification improved adhesion, was stable and samples could be stored in aqueous media. The resulting hydroxylation was further derivatized using an amino acid to provide a specialised surface. This was very different from the multiple oxygen functionalities introduced in the comparison studies by UV/ozone and plasma treatments. (author)

Nuclear Dynamics Consequence Analysis (NDCA) for the Disposal of Spent Nuclear Fuel in an Underground Geologic Repository - Volume 3: Appendices

International Nuclear Information System (INIS)

Taylor, L.L.; Wilson, J.R.; Sanchez, L.C.; Aguilar, R.; Trellue, H.R.; Cochrane, K.; Rath, J.S.

1998-01-01

The United States Department of Energy Office of Environmental Management's (DOE/EM's) National Spent Nuclear Fuel Program (NSNFP), through a collaboration between Sandia National Laboratories (SNL) and Idaho National Engineering and Environmental Laboratory (INEEL), is conducting a systematic Nuclear Dynamics Consequence Analysis (NDCA) of the disposal of SNFs in an underground geologic repository sited in unsaturated tuff. This analysis is intended to provide interim guidance to the DOE for the management of the SNF while they prepare for final compliance evaluation. This report presents results from a Nuclear Dynamics Consequence Analysis (NDCA) that examined the potential consequences and risks of criticality during the long-term disposal of spent nuclear fuel owned by DOE-EM. This analysis investigated the potential of post-closure criticality, the consequences of a criticality excursion, and the probability frequency for post-closure criticality. The results of the NDCA are intended to provide the DOE-EM with a technical basis for measuring risk which can be used for screening arguments to eliminate post-closure criticality FEPs (features, events and processes) from consideration in the compliance assessment because of either low probability or low consequences. This report is composed of an executive summary (Volume 1), the methodology and results of the NDCA (Volume 2), and the applicable appendices (Volume 3)

Posttranslational modifications of proopiomelanocortin in vertebrates and their biological significance

Directory of Open Access Journals (Sweden)

Akiyoshi eTakahashi

2013-10-01

Full Text Available Proopiomelanocortin (POMC is the precursor of several peptide hormones generated in the pituitary gland. After biosynthesis, POMC undergoes several posttranslational modifications, including proteolytic cleavage, acetylation, amidation, phosphorylation, glycosylation, and disulfide linkage formation, which generate mature POMC-derived peptides. Therefore, POMC is a useful model for the investigation of posttranslational modifications. These processes have been extensively investigated in mammals, primarily in rodents. In addition, over the last decade, much information has been obtained about the posttranslational processing of POMC in non-mammalian animals such as fish, amphibians, reptiles, and birds through sequencing and peptide identification by mass spectrometry. One POMC modification, acetylation, is known to modulate the biological activities of POMC-derived alpha-melanocyte-stimulating hormone (alpha-MSH having an acetyl group at N-terminal through potentiation or inhibition. This bidirectional regulation depends on its intrinsic roles in the tissue or cell; for example, alpha-MSH, as well as desacety-alpha-MSH, stimulates pigment dispersion in the xanthophores of a flounder. In contrast, alpha-MSH does not stimulate pigment dispersion in the melanophores of the same species, whereas desacetyl-alpha-MSH does. Regulation of pigment-dispersing activities may be associated with the subtle balance in the expression of receptor genes. In this review, we consider the posttranslational modifications of POMC in vertebrates from an evolutionary aspect, with a focus on the relationship between acetylation and the biological activities of alpha-MSH as an important consequence of posttranslational modification.

Factors Causing Delay of Modification Projects at Koeberg Nuclear Power Station

International Nuclear Information System (INIS)

Ntoyanto, S.

2017-01-01

Modification project delays could lead to: disrupting the maintenance shutdown (outage) projects' schedule, affecting electricity capacity of the national grid., possible load-shedding restricting electricity supply to domestic, commercial, and industrial consumers; and detrimental consequences to the country's economic activities. To address proficiency of a project manager by improving: Understanding of the organizational processes, High-level technical knowledge of a nuclear power plant technology

Consumer perceptions of food products involving genetic modification

DEFF Research Database (Denmark)

Grunert, Klaus G.; Lähteenmäki, L.; Nielsen, Niels Asger

2001-01-01

Product descriptions of cheese, candy and salmon products were presented to samples of respondents in four Nordic countries. The descriptions represented various applications of genetic modification (GM), varied along a "distance" dimension and a "what is modified" dimension, and were presented...... along with a conventionally produced product. Respondents ranked the products according to preference, and their perceptions were ascertained by the laddering method. Results indicate that respondents regard "non-GM" as a value in itself, and associate the use of GM with a host of negative consequences...... were product specific....

Probabilistic accident consequence uncertainty analysis: Dispersion and deposition uncertainty assessment, appendices A and B

International Nuclear Information System (INIS)

Harper, F.T.; Young, M.L.; Miller, L.A.; Hora, S.C.; Lui, C.H.; Goossens, L.H.J.; Cooke, R.M.; Paesler-Sauer, J.; Helton, J.C.

1995-01-01

The development of two new probabilistic accident consequence codes, MACCS and COSYMA, completed in 1990, estimate the risks presented by nuclear installations based on postulated frequencies and magnitudes of potential accidents. In 1991, the US Nuclear Regulatory Commission (NRC) and the Commission of the European Communities (CEC) began a joint uncertainty analysis of the two codes. The objective was to develop credible and traceable uncertainty distributions for the input variables of the codes. Expert elicitation, developed independently, was identified as the best technology available for developing a library of uncertainty distributions for the selected consequence parameters. The study was formulated jointly and was limited to the current code models and to physical quantities that could be measured in experiments. To validate the distributions generated for the wet deposition input variables, samples were taken from these distributions and propagated through the wet deposition code model along with the Gaussian plume model (GPM) implemented in the MACCS and COSYMA codes. Resulting distributions closely replicated the aggregated elicited wet deposition distributions. Project teams from the NRC and CEC cooperated successfully to develop and implement a unified process for the elaboration of uncertainty distributions on consequence code input parameters. Formal expert judgment elicitation proved valuable for synthesizing the best available information. Distributions on measurable atmospheric dispersion and deposition parameters were successfully elicited from experts involved in the many phenomenological areas of consequence analysis. This volume is the second of a three-volume document describing the project and contains two appendices describing the rationales for the dispersion and deposition data along with short biographies of the 16 experts who participated in the project

Probabilistic accident consequence uncertainty analysis: Dispersion and deposition uncertainty assessment, appendices A and B

Energy Technology Data Exchange (ETDEWEB)

Harper, F.T.; Young, M.L.; Miller, L.A. [Sandia National Labs., Albuquerque, NM (United States); Hora, S.C. [Univ. of Hawaii, Hilo, HI (United States); Lui, C.H. [Nuclear Regulatory Commission, Washington, DC (United States); Goossens, L.H.J.; Cooke, R.M. [Delft Univ. of Technology (Netherlands); Paesler-Sauer, J. [Research Center, Karlsruhe (Germany); Helton, J.C. [and others

1995-01-01

The development of two new probabilistic accident consequence codes, MACCS and COSYMA, completed in 1990, estimate the risks presented by nuclear installations based on postulated frequencies and magnitudes of potential accidents. In 1991, the US Nuclear Regulatory Commission (NRC) and the Commission of the European Communities (CEC) began a joint uncertainty analysis of the two codes. The objective was to develop credible and traceable uncertainty distributions for the input variables of the codes. Expert elicitation, developed independently, was identified as the best technology available for developing a library of uncertainty distributions for the selected consequence parameters. The study was formulated jointly and was limited to the current code models and to physical quantities that could be measured in experiments. To validate the distributions generated for the wet deposition input variables, samples were taken from these distributions and propagated through the wet deposition code model along with the Gaussian plume model (GPM) implemented in the MACCS and COSYMA codes. Resulting distributions closely replicated the aggregated elicited wet deposition distributions. Project teams from the NRC and CEC cooperated successfully to develop and implement a unified process for the elaboration of uncertainty distributions on consequence code input parameters. Formal expert judgment elicitation proved valuable for synthesizing the best available information. Distributions on measurable atmospheric dispersion and deposition parameters were successfully elicited from experts involved in the many phenomenological areas of consequence analysis. This volume is the second of a three-volume document describing the project and contains two appendices describing the rationales for the dispersion and deposition data along with short biographies of the 16 experts who participated in the project.

Evaluation of atmospheric dispersion/consequence models supporting safety analysis

International Nuclear Information System (INIS)

O'Kula, K.R.; Lazaro, M.A.; Woodard, K.

1996-01-01

Two DOE Working Groups have completed evaluation of accident phenomenology and consequence methodologies used to support DOE facility safety documentation. The independent evaluations each concluded that no one computer model adequately addresses all accident and atmospheric release conditions. MACCS2, MATHEW/ADPIC, TRAC RA/HA, and COSYMA are adequate for most radiological dispersion and consequence needs. ALOHA, DEGADIS, HGSYSTEM, TSCREEN, and SLAB are recommended for chemical dispersion and consequence applications. Additional work is suggested, principally in evaluation of new models, targeting certain models for continued development, training, and establishing a Web page for guidance to safety analysts

Global study of nuclear modifications on parton distribution functions

Directory of Open Access Journals (Sweden)

Rong Wang

2017-07-01

Full Text Available A global analysis of nuclear medium modifications of parton distributions is presented using deeply inelastic scattering data of various nuclear targets. Two obtained data sets are provided for quark and gluon nuclear modification factors, referred as nIMParton16. One is from the global fit only to the experimental data of isospin-scalar nuclei (Set A, and the other is from the fit to all the measured nuclear data (Set B. The scale-dependence is described by DGLAP equations with nonlinear corrections in this work. The Fermi motion and off-shell effect, nucleon swelling, and parton–parton recombination are taken into account together for modeling the complicated x-dependence of nuclear modification. The nuclear gluon shadowing in this paper is dynamically generated by the QCD evolution of parton splitting and recombination processes with zero gluon density at the input scale. Sophisticated nuclear dependence of nuclear medium effects is studied with only two free parameters. With the obtained free parameters from the global analysis, the nuclear modifications of parton distribution functions of unmeasured nuclei can be predicted in our model. Nuclear modification of deuteron is also predicted and shown with recent measurement at JLab.

Environmental decision support system on base of geoinformational technologies for the analysis of nuclear accident consequences

International Nuclear Information System (INIS)

Haas, T.C.; Maigan, M.; Arutyunyan, R.V.; Bolshov, L.A.; Demianov, V.V.

1996-01-01

The report deals with description of the concept and prototype of environmental decision support system (EDSS) for the analysis of late off-site consequences of severe nuclear accidents and analysis, processing and presentation of spatially distributed radioecological data. General description of the available software, use of modem achievements of geostatistics and stochastic simulations for the analysis of spatial data are presented and discussed

PARTITION: A program for defining the source term/consequence analysis interface in the NUREG--1150 probabilistic risk assessments

International Nuclear Information System (INIS)

Iman, R.L.; Helton, J.C.; Johnson, J.D.

1990-05-01

The individual plant analyses in the US Nuclear Regulatory Commission's reassessment of the risk from commercial nuclear power plants (NUREG-1150) consist of four parts: systems analysis, accident progression analysis, source term analysis, and consequence analysis. Careful definition of the interfaces between these parts is necessary for both information flow and computational efficiency. This document has been designed for users of the PARTITION computer program developed by the authors at Sandia National Laboratories for defining the interface between the source term analysis (performed with the XXSOR programs) and the consequence analysis (performed with the MACCS program). This report provides a tutorial that details how the interactive partitioning is performed, along with detailed information on the partitioning process. The PARTITION program was written in ANSI standard FORTRAN 77 to make the code as machine-independent (i.e., portable) as possible. 9 refs., 4 figs

Modifications made to the MELCOR Code for Analyzing Lithium Fires in Fusion Reactors

International Nuclear Information System (INIS)

Merrill, B.J.

2000-01-01

This report documents initial modifications made to the MELCOR code that allows MELCOR to predict the consequences of lithium spill accidents for evolving fusion reactor designs. These modifications include thermodynamic and transport properties for lithium, and physical models for predicting the rate of reaction of and energy production from the lithium-air reaction. A benchmarking study was performed with this new MELCOR capability. Two lithium-air reaction tests conducted at the Hanford Engineering Development Laboratory (HEDL) were selected for this benchmark study. Excellent agreement was achieved between MELCOR predictions and measured data. Recommendations for modeling lithium fires with MELCOR and for future work in this area are included in this report

Metformin and lifestyle modification in polycystic ovary syndrome: systematic review and meta-analysis.

Science.gov (United States)

Naderpoor, Negar; Shorakae, Soulmaz; de Courten, Barbora; Misso, Marie L; Moran, Lisa J; Teede, Helena J

2015-01-01

Polycystic ovary syndrome (PCOS) is a common endocrine disorder with diverse reproductive and metabolic features. It is underpinned by insulin resistance that is exacerbated by obesity. Lifestyle modification is the first line treatment in PCOS, but it is associated with low adherence and sustainability. In small studies, metformin improves outcomes such as hyperinsulinaemia, ovulation and menstrual cyclicity. We conducted a systematic review and meta-analysis to compare the effect of lifestyle modification + metformin with lifestyle modification ± placebo, and of metformin alone with lifestyle modification ± placebo in PCOS on anthropometric, metabolic, reproductive and psychological outcomes. Databases including MEDLINE, EMBASE, Pubmed, Scopus, Cochrane, PsycINFO, CINAHL, Clinical Trials registry and ANZCTR were searched for RCTs conducted on humans and published in English up to August 2014. Inclusion criteria were diagnosis of PCOS based on Rotterdam criteria (inclusive of National Institutes of Health criteria) at any age and with any BMI. Interventions of interest included lifestyle + metformin (with any dose and any duration) or metformin alone compared with lifestyle ± placebo. Of 2372 identified studies, 12 RCTs were included for analysis comprising 608 women with PCOS. Lifestyle + metformin were associated with lower BMI (mean difference (MD) -0.73 kg/m(2), 95% confidence intervals (CI) -1.14, -0.32, P = 0.0005) and subcutaneous adipose tissue (MD -92.49 cm(2), 95% CI -164.14, -20.84, P = 0.01) and increased number of menstrual cycles (MD 1.06, 95% CI 0.30, 1.82, P = 0.006) after 6 months compared with lifestyle ± placebo. There were no differences in other anthropometric, metabolic (surrogate markers of insulin resistance, fasting and area under the curve glucose, lipids and blood pressure), reproductive (clinical and biochemical hyperandrogenism), and psychological (quality of life) outcomes after 6 months between lifestyle + metformin compared with

Analysis and modification of blue sapphires from Rwanda by ion beam techniques

Energy Technology Data Exchange (ETDEWEB)

Bootkul, D., E-mail: mo_duangkhae@hotmail.com [Department of General Science - Gems & Jewelry, Faculty of Science, Srinakharinwirot University, Bangkok 10110 (Thailand); Chaiwai, C.; Tippawan, U. [Plasma and Beam Physics Research Facility, Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai 50200 (Thailand); Wanthanachaisaeng, B. [Gems Enhancement Research Unit, Faculty of Gems, Burapha University, Chanthaburi Campus, Chanthaburi 22170 (Thailand); Intarasiri, S., E-mail: saweat@gmail.com [Science and Technology Research Institute, Chiang Mai University, Chiang Mai 50200 (Thailand)

2015-12-15

Highlights: • Ion beam analysis is an effective method for detecting trace elements. • Ion beam treatment is able to improve optical and color appearances of the blue sapphire from Rwanda. • These alternative methods can be extended to jewelry industry for large scale application. - Abstract: Blue sapphire is categorised in a corundum (Al{sub 2}O{sub 3}) group. The gems of this group are always amazed by their beauties and thus having high value. In this study, blue sapphires from Rwanda, recently came to Thai gemstone industry, are chosen for investigations. On one hand, we have applied Particle Induced X-ray Emission (PIXE), which is a highly sensitive and precise analytical technique that can be used to identify and quantify trace elements, for chemical analysis of the sapphires. Here we have found that the major element of blue sapphires from Rwanda is Al with trace elements such as Fe, Ti, Cr, Ga and Mg as are commonly found in normal blue sapphire. On the other hand, we have applied low and medium ion implantations for color improvement of the sapphire. It seems that a high amount of energy transferring during cascade collisions have altered the gems properties. We have clearly seen that the blue color of the sapphires have been intensified after nitrogen ion bombardment. In addition, the gems were also having more transparent and luster. The UV–Vis–NIR measurement detected the modification of their absorption properties, implying of the blue color increasing. Here the mechanism of these modifications is postulated and reported. In any point of view, the bombardment by using nitrogen ion beam is a promising technique for quality improvement of the blue sapphire from Rwanda.

X-ray studies on piroxicam modifications

International Nuclear Information System (INIS)

Reck, G.; Bannier, G.; Hoehne, E.

1988-01-01

The anti-inflammatory drug piroxicam, 4-hydroxy-2-methyl-N-(2-pyridyl)2H-1,2-benzothiazine-3-car-boxamide-1,1-dioxide, crystallizes in three different forms, two anhydrates and one monohydrate. Crystal structure analyses of the monohydrate and one of the anhydrate were carried out by Bordner et al. and Kojic-Prodic et al., respectively. The results of the analysis of the third piroxicam modification and of an independently performed structure determination of the monohydrate are reported. Molecular structures and hydrogen bonding of all modifications are discussed. (author)

Use of principal components analysis and three-dimensional atmospheric-transport models for reactor-consequence evaluation

International Nuclear Information System (INIS)

Gudiksen, P.H.; Walton, J.J.; Alpert, D.J.; Johnson, J.D.

1982-01-01

This work explores the use of principal components analysis coupled to three-dimensional atmospheric transport and dispersion models for evaluating the environmental consequences of reactor accidents. This permits the inclusion of meteorological data from multiple sites and the effects of topography in the consequence evaluation; features not normally included in such analyses. The technique identifies prevailing regional wind patterns and their frequencies for use in the transport and dispersion calculations. Analysis of a hypothetical accident scenario involving a release of radioactivity from a reactor situated in a river valley indicated the technique is quite useful whenever recurring wind patterns exist, as is often the case in complex terrain situations. Considerable differences were revealed in a comparison with results obtained from a more conventional Gaussian plume model using only the reactor site meteorology and no topographic effects

Evaluating the effects of dam breach methodologies on Consequence Estimation through Sensitivity Analysis

Science.gov (United States)

Kalyanapu, A. J.; Thames, B. A.

2013-12-01

Dam breach modeling often includes application of models that are sophisticated, yet computationally intensive to compute flood propagation at high temporal and spatial resolutions. This results in a significant need for computational capacity that requires development of newer flood models using multi-processor and graphics processing techniques. Recently, a comprehensive benchmark exercise titled the 12th Benchmark Workshop on Numerical Analysis of Dams, is organized by the International Commission on Large Dams (ICOLD) to evaluate the performance of these various tools used for dam break risk assessment. The ICOLD workshop is focused on estimating the consequences of failure of a hypothetical dam near a hypothetical populated area with complex demographics, and economic activity. The current study uses this hypothetical case study and focuses on evaluating the effects of dam breach methodologies on consequence estimation and analysis. The current study uses ICOLD hypothetical data including the topography, dam geometric and construction information, land use/land cover data along with socio-economic and demographic data. The objective of this study is to evaluate impacts of using four different dam breach methods on the consequence estimates used in the risk assessments. The four methodologies used are: i) Froehlich (1995), ii) MacDonald and Langridge-Monopolis 1984 (MLM), iii) Von Thun and Gillete 1990 (VTG), and iv) Froehlich (2008). To achieve this objective, three different modeling components were used. First, using the HEC-RAS v.4.1, dam breach discharge hydrographs are developed. These hydrographs are then provided as flow inputs into a two dimensional flood model named Flood2D-GPU, which leverages the computer's graphics card for much improved computational capabilities of the model input. Lastly, outputs from Flood2D-GPU, including inundated areas, depth grids, velocity grids, and flood wave arrival time grids, are input into HEC-FIA, which provides the

Epigenetic modifications: basic mechanisms and role in cardiovascular disease (2013 Grover Conference series)

OpenAIRE

Loscalzo, Joseph; Handy, Diane E.

2014-01-01

Abstract Epigenetics refers to heritable traits that are not a consequence of DNA sequence. Three classes of epigenetic regulation exist: DNA methylation, histone modification, and noncoding RNA action. In the cardiovascular system, epigenetic regulation affects development, differentiation, and disease propensity or expression. Defining the determinants of epigenetic regulation offers opportunities for novel strategies for disease prevention and treatment.

Epigenetic modifications: basic mechanisms and role in cardiovascular disease (2013 Grover Conference series).

Science.gov (United States)

Loscalzo, Joseph; Handy, Diane E

2014-06-01

Epigenetics refers to heritable traits that are not a consequence of DNA sequence. Three classes of epigenetic regulation exist: DNA methylation, histone modification, and noncoding RNA action. In the cardiovascular system, epigenetic regulation affects development, differentiation, and disease propensity or expression. Defining the determinants of epigenetic regulation offers opportunities for novel strategies for disease prevention and treatment.

Theoretical analysis of epigenetic cell memory by nucleosome modification

DEFF Research Database (Denmark)

Dodd, Ian B; Micheelsen, Mille A; Sneppen, Kim

2007-01-01

to involve positive feedback where modified nucleosomes recruit enzymes that similarly modify nearby nucleosomes. We developed a simplified stochastic model for dynamic nucleosome modification based on the silent mating-type region of the yeast Schizosaccharomyces pombe. We show that the mechanism can give...

An integrative analysis of post-translational histone modifications in the marine diatom Phaeodactylum tricornutum

KAUST Repository

Veluchamy, Alaguraj

2015-05-20

Background: Nucleosomes are the building blocks of chromatin where gene regulation takes place. Chromatin landscapes have been profiled for several species, providing insights into the fundamental mechanisms of chromatin-mediated transcriptional regulation of gene expression. However, knowledge is missing for several major and deep-branching eukaryotic groups, such as the Stramenopiles, which include the diatoms. Diatoms are highly diverse and ubiquitous species of phytoplankton that play a key role in global biogeochemical cycles. Dissecting chromatin-mediated regulation of genes in diatoms will help understand the ecological success of these organisms in contemporary oceans. Results: Here, we use high resolution mass spectrometry to identify a full repertoire of post-translational modifications on histones of the marine diatom Phaeodactylum tricornutum, including eight novel modifications. We map five histone marks coupled with expression data and show that P. tricornutum displays both unique and broadly conserved chromatin features, reflecting the chimeric nature of its genome. Combinatorial analysis of histone marks and DNA methylation demonstrates the presence of an epigenetic code defining activating or repressive chromatin states. We further profile three specific histone marks under conditions of nitrate depletion and show that the histone code is dynamic and targets specific sets of genes. Conclusions: This study is the first genome-wide characterization of the histone code from a stramenopile and a marine phytoplankton. The work represents an important initial step for understanding the evolutionary history of chromatin and how epigenetic modifications affect gene expression in response to environmental cues in marine environments. © 2015 Veluchamy et al.

Quasifree η photoproduction from nuclei and medium modifications of resonances

International Nuclear Information System (INIS)

Ventel, B.I.S. van der; Abu-Raddad, L.J.; Hillhouse, G.C.

2003-01-01

This paper establishes the case that the process of quasifree η photoproduction from nuclei is an important tool to study medium modifications and changes to the elementary process γN→ηN in the nuclear medium. We investigate the sensitivity of the differential cross section, recoil nucleon polarization, and the photon asymmetry to changes in the elementary amplitude, medium modifications of the resonance (S 11 ,D 13 ) masses, as well as nuclear target effects. All calculations are performed within a relativistic plane-wave impulse approximation formalism resulting in analytical expressions for all observables. Our results indicate that polarization observables are largely insensitive to nuclear target effects. Depending on the type of coupling, the spin observables do display a sensitivity to the magnitude of the ηNN coupling constant. The polarization observables are identified to be the prime candidates to investigate the background processes and their medium modifications in the elementary process such as the D 13 resonance. Moreover, as a consequence of the large dominance in the differential cross section of the S 11 resonance, the quasifree differential cross section provides an exceptional instrument to study medium modifications to the S 11 resonance in such a manner that helps to distinguish between various models that attempt to understand the S 11 resonance and its distinctive position as the lowest lying negative parity state in the baryon spectrum

Nuclear Dynamics Consequence Analysis (NDCA) for the Disposal of Spent Nuclear Fuel in an Underground Geologic Repository--Volume 1: Executive Summary

International Nuclear Information System (INIS)

Taylor, L.L.; Wilson, J.R.; Sanchez, L.Z.; Aguilar, R.; Trellue, H.R.; Cochrane, K.; Rath, J.S.

1998-01-01

The US Department of Energy Office of Environmental Management's (DOE/EM's) National Spent Nuclear Fuel Program (NSNFP), through a collaboration between Sandia National Laboratories (SNL) and Idaho National Engineering and Environmental Laboratory (INEEL), is conducting a systematic Nuclear Dynamics Consequence Analysis (NDCA) of the disposal of SNFs in an underground geologic repository sited in unsaturated tuff. This analysis is intended to provide interim guidance to the DOE for the management of the SNF while they prepare for final compliance evaluation. This report presents results from a Nuclear Dynamics Consequence Analysis (NDCA) that examined the potential consequences and risks of criticality during the long-term disposal of spent nuclear fuel owned by DOE-EM. This analysis investigated the potential of post-closure criticality, the consequences of a criticality excursion, and the probability frequency for post-closure criticality. The results of the NDCA are intended to provide the DOE-EM with a technical basis for measuring risk which can be used for screening arguments to eliminate post-closure criticality FEPs (features, events and processes) from consideration in the compliance assessment because of either low probability or low consequences. This report is composed of an executive summary (Volume 1), the methodology and results of the NDCA (Volume 2), and the applicable appendices (Volume 3)

Modification of a cyclo-olefin surface by radio-sterilization: is there any effect on the interaction with drug solutions?

Science.gov (United States)

Barakat, Hala; Saunier, Johanna; Aymes Chodur, Caroline; Aubert, Pascal; Vigneron, Jackie; Etcheberry, Arnaud; Yagoubi, Najet

2013-11-01

A cyclo-olefin copolymer was subjected to an e-beam ionizing treatment. Two doses were studied: one corresponding to the recommended dose for the sterilization of pharmaceutical packaging (25 kGy), and a greater one to enhance the modifications caused by the treatment (150 kGy). The surface modifications were studied by X-ray photoelectron spectroscopy (XPS), contact angle measurements and atomic force microscopy (AFM). The roughness and the wettability of the surface were enhanced by the treatment. The consequences of the surface modifications on the drug interaction with the polymer were studied. Copyright © 2013 Elsevier B.V. All rights reserved.

Surface modification of polyethylene by plasma

International Nuclear Information System (INIS)

Colin O, E.

2003-01-01

The products made of polyethylene (PE) go from construction materials, electric insulating until packing material. The films for bags and pack occupy 83.6% of the distribution of the market of PE approximately. The enormous quantity of PE that is generated by its indiscriminate use brings as consequence a deterioration to the atmosphere, due to the long life that they present as waste. This work is a study on the modification of low density polyethylene films. In this type of thin materials, the changes in the surface meet with largely on the conformation of the rest of the material. To induce changes that modify the surface of PE, plasmas were used with reactive atmospheres of air, oxygen and nitrogen. The experimentation that was carries out went to introduce the PE to a cylindrical reactor where it was generated the plasma of air, oxygen and nitrogen to different times of exposure. After having carried out the exposure to the plasma, it was found that in the polyethylene it modifies their morphology, crystallinity, hydrophobicity, composition and electric conductivity. The analytical techniques that were used to characterize later to the polyethylene of being in contact with the plasma were: X-ray diffraction, Scanning Electron Microscopy, Infrared spectroscopy, Electric conductivity, Angle of contact and finally Thermal Gravimetric Analysis. The content of this work it is presented in five chapters: In the chapter 1 there are presented some general concepts of plasma and of the one polymer in study PE. In the chapter 2 it is made a general revision on modification of surfaces, as well as the properties that were modified in polymeric materials that were exposed to plasma in previous works. In the chapter 3 the experimental part and the conditions used are described in the modification of the PE. Also in this chapter a brief description it is made of the used characterization techniques. The results and discussion are presented in the chapter 4. These results

Analysis of epigenetic modifications of DNA in human cells

DEFF Research Database (Denmark)

Kristensen, Lasse Sommer; Treppendahl, Marianne Bach; Grønbæk, Kirsten

2013-01-01

Epigenetics, the study of somatically heritable changes in gene expression not related to changes in the DNA sequence, is a rapidly expanding research field that plays important roles in healthy as well as in diseased cells. DNA methylation and hydroxymethylation are epigenetic modifications found...

Modification of computational auditory scene analysis (CASA) for noise-robust acoustic feature

Science.gov (United States)

Kwon, Minseok

While there have been many attempts to mitigate interferences of background noise, the performance of automatic speech recognition (ASR) still can be deteriorated by various factors with ease. However, normal hearing listeners can accurately perceive sounds of their interests, which is believed to be a result of Auditory Scene Analysis (ASA). As a first attempt, the simulation of the human auditory processing, called computational auditory scene analysis (CASA), was fulfilled through physiological and psychological investigations of ASA. CASA comprised of Zilany-Bruce auditory model, followed by tracking fundamental frequency for voice segmentation and detecting pairs of onset/offset at each characteristic frequency (CF) for unvoiced segmentation. The resulting Time-Frequency (T-F) representation of acoustic stimulation was converted into acoustic feature, gammachirp-tone frequency cepstral coefficients (GFCC). 11 keywords with various environmental conditions are used and the robustness of GFCC was evaluated by spectral distance (SD) and dynamic time warping distance (DTW). In "clean" and "noisy" conditions, the application of CASA generally improved noise robustness of the acoustic feature compared to a conventional method with or without noise suppression using MMSE estimator. The intial study, however, not only showed the noise-type dependency at low SNR, but also called the evaluation methods in question. Some modifications were made to capture better spectral continuity from an acoustic feature matrix, to obtain faster processing speed, and to describe the human auditory system more precisely. The proposed framework includes: 1) multi-scale integration to capture more accurate continuity in feature extraction, 2) contrast enhancement (CE) of each CF by competition with neighboring frequency bands, and 3) auditory model modifications. The model modifications contain the introduction of higher Q factor, middle ear filter more analogous to human auditory system

Identifying modifications in RNA by MALDI mass spectrometry

DEFF Research Database (Denmark)

Douthwaite, Stephen; Kirpekar, Finn

2007-01-01

as RNA modifications added in cell-free in vitro systems. MALDI-MS is particularly useful in cases in which other techniques such as those involving primer extension or chromatographic analyses are not practicable. To date, MALDI-MS has been used to localize rRNA modifications that are involved......Posttranscriptional modifications on the base or sugar of ribonucleosides generally result in mass increases that can be measured by mass spectrometry. Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is a direct and accurate means of determining the masses of RNAs. Mass...... spectra produced by MALDI are relatively straightforward to interpret, because they are dominated by singly charged ions, making it possible to analyze complex mixtures of RNA oligonucleotides ranging from trinucleotides up to 20-mers. Analysis of modifications within much longer RNAs, such as ribosomal...

Analysis of uncertainties caused by the atmospheric dispersion model in accident consequence assessments with UFOMOD

International Nuclear Information System (INIS)

Fischer, F.; Ehrhardt, J.

1988-06-01

Various techniques available for uncertainty analysis of large computer models are applied, described and selected as most appropriate for analyzing the uncertainty in the predictions of accident consequence assessments. The investigation refers to the atmospheric dispersion and deposition submodel (straight-line Gaussian plume model) of UFOMOD, whose most important input variables and parameters are linked with probability distributions derived from expert judgement. Uncertainty bands show how much variability exists, sensitivity measures determine what causes this variability in consequences. Results are presented as confidence bounds of complementary cumulative frequency distributions (CCFDs) of activity concentrations, organ doses and health effects, partially as a function of distance from the site. In addition the ranked influence of the uncertain parameters on the different consequence types is shown. For the estimation of confidence bounds it was sufficient to choose a model parameter sample size of n (n=59) equal to 1.5 times the number of uncertain model parameters. Different samples or an increase of sample size did not change the 5%-95% - confidence bands. To get statistically stable results of the sensitivity analysis, larger sample sizes are needed (n=100, 200). Random or Latin-hypercube sampling schemes as tools for uncertainty and sensitivity analyses led to comparable results. (orig.) [de

Ion beam modification and analysis of thin YBa2Cu3O7 films

International Nuclear Information System (INIS)

Meyer, O.

1989-04-01

The application of ion beams for the analysis and modification of high Tc superconductors is reviewed. Ion backscattering and channeling spectroscopy is used to optimize the film composition and the epitaxial growth performance on various single crystalline substrates. The influence of radiation damage on the transport properties and on the structure of polycrystalline as well as of single crystalline thin films is presented. The irradiation induced metal to insulator phase transition is discussed in detail. Some applications including the use of ion implantation for structuring are summarized. (orig.) [de

Exploratory Factor Analysis of NRG Oncology's University of Washington Quality of Life Questionnaire – RTOG Modification

Science.gov (United States)

Pugh, Stephanie L.; Wyatt, Gwen; Wong, Raimond K. W.; Sagar, Stephen M.; Yueh, Bevan; Singh, Anurag K.; Yao, Min; Nguyen-Tan, Phuc Felix; Yom, Sue S.; Cardinale, Francis S.; Sultanem, Khalil; Hodson, D. Ian; Krempl, Greg A.; Chavez, Ariel; Yeh, Alexander M.; Bruner, Deborah W.

2016-01-01

Context The 15-item University of Washington Quality of Life questionnaire – Radiation Therapy Oncology Group (RTOG) modification (UW-QOL-RTOG modification) has been used in several trials of head and neck cancer conducted by NRG Oncology such as RTOG 9709, RTOG 9901, RTOG 0244, and RTOG 0537. Objectives This study is an exploratory factor analysis (EFA) to establish validity and reliability of the instrument subscales. Methods EFA on the UW-QOL - RTOG modification was conducted using baseline data from NRG Oncology's RTOG 0537, a trial of acupuncture-like transcutaneous electrical nerve stimulation in treating radiation-induced xerostomia. Cronbach's α coefficient was calculated to measure reliability; correlation with the University of Michigan Xerostomia Related Quality of Life Scale (XeQOLS) was used to evaluate concurrent validity; and correlations between consecutive time points were used to assess test-retest reliability. Results The 15-item EFA of the modified tool resulted in 11 items split into 4 factors: mucus, eating, pain, and activities. Cronbach's α ranged from 0.71 to 0.93 for the factors and total score, consisting of all 11 items. There were strong correlations (ρ≥0.60) between consecutive time points and between total score and the XeQOLS total score (ρ>0.65). Conclusion The UW-QOL-RTOG modification is a valid tool that can be used to assess symptom burden of head and neck cancer patients receiving radiation therapy or those who have recently completed radiation. The modified tool has acceptable reliability, concurrent validity, and test-retest reliability in this patient population, as well as the advantage of having being shortened from 15 to 11 items. PMID:27899312

Tyrosine residues modification studied by MALDI-TOF mass spectrometry

International Nuclear Information System (INIS)

Santrucek, Jiri; Strohalm, Martin; Kadlcik, Vojtech; Hynek, Radovan; Kodicek, Milan

2004-01-01

Amino acid residue-specific reactivity in proteins is of great current interest in structural biology as it provides information about solvent accessibility and reactivity of the residue and, consequently, about protein structure and possible interactions. In the work presented tyrosine residues of three model proteins with known spatial structure are modified with two tyrosine-specific reagents: tetranitromethane and iodine. Modified proteins were specifically digested by proteases and the mass of resulting peptide fragments was determined using matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry. Our results show that there are only small differences in the extent of tyrosine residues modification by tetranitromethane and iodine. However, data dealing with accessibility of reactive residues obtained by chemical modifications are not completely identical with those obtained by nuclear magnetic resonance and X-ray crystallography. These interesting discrepancies can be caused by local molecular dynamics and/or by specific chemical structure of the residues surrounding

Modification of grey scale in computer tomographic images

International Nuclear Information System (INIS)

Hemmingsson, A.; Jung, B.

1980-01-01

Optimum perception of minute but relevant attenuation differences in CT images often requires display window settings so narrow that a considerable fraction of the image appears completely black or white and consequently without structure. In order to improve the display characteristics two principles of grey scale modification are presented. In one method the pixel contents are displayed unchanged within a selectable attenuation band but moved towards the limits of the band for pixels that are outside it. In the other the grey scale is arranged to a constant number of pixels per grey scale interval. (Auth.)

Recent Advances in Attention Bias Modification for Substance Addictions

Directory of Open Access Journals (Sweden)

Melvyn Weibin Zhang

2018-04-01

Full Text Available Research on attentional bias modification has increased since 2014. A recent meta-analysis demonstrates evidence for bias modification for substance disorders, including alcohol and tobacco use disorders. Several pharmacological trials have shown that pharmacological agents can attenuate and modify such attentional bias. The pharmacological trials that have appeared to date have produced mixed results, which has clinical implications. Developments in Internet and mobile technologies have transformed how attention bias modification is currently being achieved. There remains great potential for further research that examines the efficacy of technology-aided attention bias interventions.

Modification of semiconductors with proton beams. A review

International Nuclear Information System (INIS)

Kozlovskii, V.V.; Lomasov, V.N.; Kozlov, V.A.

2000-01-01

Analysis is given of the progress in the modification of semiconductors by proton beams in fields such as proton-enhanced diffusion, ion-beam mixing, and formation of porous layers. This method of modification (doping) is shown to have high potential in monitoring the properties of semiconductor materials and designing devices of micro and nano electronics as compared to the conventional doping techniques such as thermal diffusion, epitaxy, and ion implantation

Safety in the Utilization and Modification of Research Reactors. Specific Safety Guide

Energy Technology Data Exchange (ETDEWEB)

NONE

2012-07-15

This Safety Guide is a revision of Safety Series No. 35-G2 on safety in the utilization and modification of research reactors. It provides recommendations on meeting the requirements for the categorization, safety assessment and approval of research reactor experiments and modification projects. Specific safety considerations in different phases of utilization and modification projects are covered, including the pre-implementation, implementation and post-implementation phases. Guidance is also provided on the operational safety of experiments, including in the handling, dismantling, post-irradiation examination and disposal of experimental devices. Examples of the application of the safety categorization process for experiments and modification projects and of the content of the safety analysis report for an experiment are also provided. Contents: 1. Introduction; 2. Management system for the utilization and modification of a research reactor; 3. Categorization, safety assessment and approval of an experiment or modification; 4. Safety considerations for the design of an experiment or modification; 5. Pre-implementation phase of a modification or utilization project; 6. Implementation phase of a modification or utilization project; 7. Post-implementation phase of a utilization or modification project; 8. Operational safety of experiments at a research reactor; 9. Safety considerations in the handling, dismantling, post-irradiation examination and disposal of experimental devices; 10. Safety aspects of out-of-reactor-core installations; Annex I: Example of a checklist for the categorization of an experiment or modification at a research reactor; Annex II: Example of the content of the safety analysis report for an experiment at a research reactor; Annex III: Examples of reasons for a modification at a research reactor.

Safety in the Utilization and Modification of Research Reactors. Specific Safety Guide

International Nuclear Information System (INIS)

2012-01-01

This Safety Guide is a revision of Safety Series No. 35-G2 on safety in the utilization and modification of research reactors. It provides recommendations on meeting the requirements for the categorization, safety assessment and approval of research reactor experiments and modification projects. Specific safety considerations in different phases of utilization and modification projects are covered, including the pre-implementation, implementation and post-implementation phases. Guidance is also provided on the operational safety of experiments, including in the handling, dismantling, post-irradiation examination and disposal of experimental devices. Examples of the application of the safety categorization process for experiments and modification projects and of the content of the safety analysis report for an experiment are also provided. Contents: 1. Introduction; 2. Management system for the utilization and modification of a research reactor; 3. Categorization, safety assessment and approval of an experiment or modification; 4. Safety considerations for the design of an experiment or modification; 5. Pre-implementation phase of a modification or utilization project; 6. Implementation phase of a modification or utilization project; 7. Post-implementation phase of a utilization or modification project; 8. Operational safety of experiments at a research reactor; 9. Safety considerations in the handling, dismantling, post-irradiation examination and disposal of experimental devices; 10. Safety aspects of out-of-reactor-core installations; Annex I: Example of a checklist for the categorization of an experiment or modification at a research reactor; Annex II: Example of the content of the safety analysis report for an experiment at a research reactor; Annex III: Examples of reasons for a modification at a research reactor.

Analysis and modification of blue sapphires from Rwanda by ion beam techniques

Science.gov (United States)

Bootkul, D.; Chaiwai, C.; Tippawan, U.; Wanthanachaisaeng, B.; Intarasiri, S.

2015-12-01

Blue sapphire is categorised in a corundum (Al2O3) group. The gems of this group are always amazed by their beauties and thus having high value. In this study, blue sapphires from Rwanda, recently came to Thai gemstone industry, are chosen for investigations. On one hand, we have applied Particle Induced X-ray Emission (PIXE), which is a highly sensitive and precise analytical technique that can be used to identify and quantify trace elements, for chemical analysis of the sapphires. Here we have found that the major element of blue sapphires from Rwanda is Al with trace elements such as Fe, Ti, Cr, Ga and Mg as are commonly found in normal blue sapphire. On the other hand, we have applied low and medium ion implantations for color improvement of the sapphire. It seems that a high amount of energy transferring during cascade collisions have altered the gems properties. We have clearly seen that the blue color of the sapphires have been intensified after nitrogen ion bombardment. In addition, the gems were also having more transparent and luster. The UV-Vis-NIR measurement detected the modification of their absorption properties, implying of the blue color increasing. Here the mechanism of these modifications is postulated and reported. In any point of view, the bombardment by using nitrogen ion beam is a promising technique for quality improvement of the blue sapphire from Rwanda.

Probabilistic Criticality Consequence Evaluation

International Nuclear Information System (INIS)

P. Gottlieb; J.W. Davis; J.R. Massari

1996-01-01

This analysis is prepared by the Mined Geologic Disposal System (MGDS) Waste Package Development (WPD) department with the objective of providing a comprehensive, conservative estimate of the consequences of the criticality which could possibly occur as the result of commercial spent nuclear fuel emplaced in the underground repository at Yucca Mountain. The consequences of criticality are measured principally in terms of the resulting changes in radionuclide inventory as a function of the power level and duration of the criticality. The purpose of this analysis is to extend the prior estimates of increased radionuclide inventory (Refs. 5.52 and 5.54), for both internal and external criticality. This analysis, and similar estimates and refinements to be completed before the end of fiscal year 1997, will be provided as input to Total System Performance Assessment-Viability Assessment (TSPA-VA) to demonstrate compliance with the repository performance objectives

Fukushima, two years later, modification requirements in nuclear power plants; Fukushima, dos anos despues, requerimientos de modificacion en centrales nucleares de potencia

Energy Technology Data Exchange (ETDEWEB)

Sanchez J, J.; Camargo C, R.; Nunez C, A.; Mendoza F, J. E.; Salmeron V, J. A., E-mail: jerson.sanchez@cnsns.gob.mx [Comision Nacional de Seguridad Nuclear y Salvaguardias, Dr. Jose Ma. Barragan No. 779, Col. Narvarte, 03020 Mexico D. F. (Mexico)

2013-10-15

The occurred events in the nuclear power plant of Fukushima Daiichi as consequence of the strong earthquake of 9 grades in the Richter scale and the later tsunami with waves estimated in more than 14 meters high began a series of important questions about the safety of the nuclear power plants in operation and of the new designs. Firstly, have allowed to be questioned on the magnitudes and consequences of the extreme external natural events; that can put in risk the integrity of the safety barriers of a nuclear power plant when being presented in a multiple way. As consequence of the events of the Fukushima Daiichi NPP, the countries with NPPs in operation and /or construction carried out evaluations about their safety operation. They have also realized evaluations about accidents and their impact in the safety, analysis and studies too that have forced to the regulatory bodies to continue a systematic and methodical revision of their procedures and regulations, to identify the possible improvements to the safety in response to the events happened in Japan; everything has taken it to determine the necessity to incorporate additional requirements to the nuclear power plants to mitigate events Beyond the Design Base. Due to Mexico has the nuclear power plant of Laguna Verde, with two units of BWR-5 type with contention Mark III, some the modifications can be applicable to these units to administrate and/or to mitigate the consequences of the possible occurrence of an accident Beyond the Design Base and that could generate a severe accident. In this work an exposition is presented on the modification requirements to confront external natural events Beyond the Design Base, and its application in our country. (Author)

Radiological consequence analysis with HEU and LEU fuels

Energy Technology Data Exchange (ETDEWEB)

Woodruff, W.L.; Warinner, D.K.; Matos, J.E.

1984-01-01

A model for estimating the radiological consequences from a hypothetical accident in HEU and LEU fueled research and test reactors is presented. Simple hand calculations based on fission product yield table inventories and non-site specific dispersion data may be adequate in many cases. However, more detailed inventories and site specific data on meteorological conditions and release rates and heights can result in substantial reductions in the dose estimates. LEU fuel gives essentially the same doses as HEU fuel. The plutonium buildup in the LEU fuel does not significantly increase the radiological consequences. The dose to the thyroid is the limiting dose. 10 references, 3 figures, 7 tables.

Radiological consequence analysis with HEU and LEU fuels

International Nuclear Information System (INIS)

Woodruff, W.L.; Warinner, D.K.; Matos, J.E.

1984-01-01

A model for estimating the radiological consequences from a hypothetical accident in HEU and LEU fueled research and test reactors is presented. Simple hand calculations based on fission product yield table inventories and non-site specific dispersion data may be adequate in many cases. However, more detailed inventories and site specific data on meteorological conditions and release rates and heights can result in substantial reductions in the dose estimates. LEU fuel gives essentially the same doses as HEU fuel. The plutonium buildup in the LEU fuel does not significantly increase the radiological consequences. The dose to the thyroid is the limiting dose. 10 references, 3 figures, 7 tables

Motivation and Consequences of Lying. A Qualitative Analysis of Everyday Lying

Directory of Open Access Journals (Sweden)

Beata Arcimowicz

2015-09-01

Full Text Available This article presents findings of qualitative analysis of semi-structured interviews with a group of "frequent liars" and another of "rare liars" who provided their subjective perspectives on the phenomenon of lying. Participants in this study previously had maintained a diary of their social interactions and lies over the course of one week, which allowed to assign them to one of the two groups: frequent or rare liars. Thematic analysis of the material followed by elements of theory formulation resulted in an extended lying typology that includes not only the target of the lie (the liar vs. other but also the motivation (protection vs. bringing benefits. We offer an analysis of what prevents from telling the truth, i.e. penalties, relationship losses, distress of the lied-to, and anticipated lack of criticism for telling the truth. We also focus on understanding moderatorsof consequences of lying (significance of the area of life, the type of lie and capacity to understand the liar that can be useful in future studies. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1503318

Mass-spectrometry analysis of histone post-translational modifications in pathology tissue using the PAT-H-MS approach

Directory of Open Access Journals (Sweden)

Roberta Noberini

2016-06-01

Full Text Available Aberrant histone post-translational modifications (hPTMs have been implicated with various pathologies, including cancer, and may represent useful epigenetic biomarkers. The data described here provide a mass spectrometry-based quantitative analysis of hPTMs from formalin-fixed paraffin-embedded (FFPE tissues, from which histones were extracted through the recently developed PAT-H-MS method. First, we analyzed FFPE samples from mouse spleen and liver or human breast cancer up to six years old, together with their corresponding fresh frozen tissue. We then combined the PAT-H-MS approach with a histone-focused version of the super-SILAC strategy-using a mix of histones from four breast cancer cell lines as a spike-in standard- to accurately quantify hPTMs from breast cancer specimens belonging to different subtypes. The data, which are associated with a recent publication (Pathology tissue-quantitative mass spectrometry analysis to profile histone post-translational modification patterns in patient samples (Noberini, 2015 [1], are deposited at the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier http://www.ebi.ac.uk/pride/archive/projects/PXD002669.

Nuclear Dynamics Consequence Analysis (NDCA) for the Disposal of Spent Nuclear Fuel in an Underground Geologic Repository--Volume 2: Methodology and Results

International Nuclear Information System (INIS)

Taylor, L.L.; Wilson, J.R.; Sanchez, L.C.; Aguilar, R.; Trellue, H.R.; Cochrane, K.; Rath, J.S.

1998-01-01

The US Department of Energy Office of Environmental Management's (DOE/EM's) National Spent Nuclear Fuel Program (NSNFP), through a collaboration between Sandia National Laboratories (SNL) and Idaho National Engineering and Environmental Laboratory (INEEL), is conducting a systematic Nuclear Dynamics Consequence Analysis (NDCA) of the disposal of SNFs in an underground geologic repository sited in unsaturated tuff. This analysis is intended to provide interim guidance to the DOE for the management of the SNF while they prepare for final compliance evaluation. This report presents results from a Nuclear Dynamics Consequence Analysis (NDCA) that examined the potential consequences and risks of criticality during the long-term disposal of spent nuclear fuel owned by DOE-EM. This analysis investigated the potential of post-closure criticality, the consequences of a criticality excursion, and the probability frequency for post-closure criticality. The results of the NDCA are intended to provide the DOE-EM with a technical basis for measuring risk which can be used for screening arguments to eliminate post-closure criticality FEPs (features, events and processes) from consideration in the compliance assessment because of either low probability or low consequences. This report is composed of an executive summary (Volume 1), the methodology and results of the NDCA (Volume 2), and the applicable appendices (Volume 3)

Nuclear Dynamics Consequence Analysis (NDCA) for the Disposal of Spent Nuclear Fuel in an Underground Geologic Repository--Volume 2: Methodology and Results

Energy Technology Data Exchange (ETDEWEB)

Taylor, L.L.; Wilson, J.R.; Sanchez, L.C.; Aguilar, R.; Trellue, H.R.; Cochrane, K.; Rath, J.S.

1998-10-01

The US Department of Energy Office of Environmental Management's (DOE/EM's) National Spent Nuclear Fuel Program (NSNFP), through a collaboration between Sandia National Laboratories (SNL) and Idaho National Engineering and Environmental Laboratory (INEEL), is conducting a systematic Nuclear Dynamics Consequence Analysis (NDCA) of the disposal of SNFs in an underground geologic repository sited in unsaturated tuff. This analysis is intended to provide interim guidance to the DOE for the management of the SNF while they prepare for final compliance evaluation. This report presents results from a Nuclear Dynamics Consequence Analysis (NDCA) that examined the potential consequences and risks of criticality during the long-term disposal of spent nuclear fuel owned by DOE-EM. This analysis investigated the potential of post-closure criticality, the consequences of a criticality excursion, and the probability frequency for post-closure criticality. The results of the NDCA are intended to provide the DOE-EM with a technical basis for measuring risk which can be used for screening arguments to eliminate post-closure criticality FEPs (features, events and processes) from consideration in the compliance assessment because of either low probability or low consequences. This report is composed of an executive summary (Volume 1), the methodology and results of the NDCA (Volume 2), and the applicable appendices (Volume 3).

Uncertainty and sensitivity analysis of early exposure results with the MACCS Reactor Accident Consequence Model

International Nuclear Information System (INIS)

Helton, J.C.; Johnson, J.D.; McKay, M.D.; Shiver, A.W.; Sprung, J.L.

1995-01-01

Uncertainty and sensitivity analysis techniques based on Latin hypercube sampling, partial correlation analysis and stepwise regression analysis are used in an investigation with the MACCS model of the early health effects associated with a severe accident at a nuclear power station. The primary purpose of this study is to provide guidance on the variables to be considered in future review work to reduce the uncertainty in the important variables used in the calculation of reactor accident consequences. The effects of 34 imprecisely known input variables on the following reactor accident consequences are studied: number of early fatalities, number of cases of prodromal vomiting, population dose within 10 mi of the reactor, population dose within 1000 mi of the reactor, individual early fatality probability within 1 mi of the reactor, and maximum early fatality distance. When the predicted variables are considered collectively, the following input variables were found to be the dominant contributors to uncertainty: scaling factor for horizontal dispersion, dry deposition velocity, inhalation protection factor for nonevacuees, groundshine shielding factor for nonevacuees, early fatality hazard function alpha value for bone marrow exposure, and scaling factor for vertical dispersion

Probabilistic accident consequence uncertainty analysis -- Uncertainty assessment for deposited material and external doses. Volume 2: Appendices

Energy Technology Data Exchange (ETDEWEB)

Goossens, L.H.J.; Kraan, B.C.P.; Cooke, R.M. [Delft Univ. of Technology (Netherlands); Boardman, J. [AEA Technology (United Kingdom); Jones, J.A. [National Radiological Protection Board (United Kingdom); Harper, F.T.; Young, M.L. [Sandia National Labs., Albuquerque, NM (United States); Hora, S.C. [Univ. of Hawaii, Hilo, HI (United States)

1997-12-01

The development of two new probabilistic accident consequence codes, MACCS and COSYMA, was completed in 1990. These codes estimate the consequence from the accidental releases of radiological material from hypothesized accidents at nuclear installations. In 1991, the US Nuclear Regulatory Commission and the Commission of the European Communities began cosponsoring a joint uncertainty analysis of the two codes. The ultimate objective of this joint effort was to systematically develop credible and traceable uncertainty distributions for the respective code input variables. A formal expert judgment elicitation and evaluation process was identified as the best technology available for developing a library of uncertainty distributions for these consequence parameters. This report focuses on the results of the study to develop distribution for variables related to the MACCS and COSYMA deposited material and external dose models. This volume contains appendices that include (1) a summary of the MACCS and COSYMA consequence codes, (2) the elicitation questionnaires and case structures, (3) the rationales and results for the panel on deposited material and external doses, (4) short biographies of the experts, and (5) the aggregated results of their responses.

Analysis of Changes in SUMO-2/3 Modification during Breast Cancer Progression and Metastasis

DEFF Research Database (Denmark)

Subramonian, Divya; Raghunayakula, Sarita; Olsen, Jesper V

2014-01-01

SUMOylation is an essential posttranslational modification and regulates many cellular processes. Dysregulation of SUMOylation plays a critical role in metastasis, yet how its perturbation affects this lethal process of cancer is not well understood. We found that SUMO-2/3 modification is greatly...... in metastatic cells. Targets with altered SUMOylation are involved in cell cycle, migration, inflammation, glycolysis, gene expression, and SUMO/ubiquitin pathways, suggesting that perturbations of SUMO-2/3 modification might contribute to metastasis by affecting these processes. Consistent with this, up...... progression and metastasis....

Albumin modification and fragmentation in renal disease.

Science.gov (United States)

Donadio, Carlo; Tognotti, Danika; Donadio, Elena

2012-02-18

Albumin is the most important antioxidant substance in plasma and performs many physiological functions. Furthermore, albumin is the major carrier of endogenous molecules and exogenous ligands. This paper reviews the importance of post-translational modifications of albumin and fragments thereof in patients with renal disease. First, current views and controversies on renal handling of proteins, mainly albumin, will be discussed. Post-translational modifications, namely the fragmentation of albumin found with proteomic techniques in nephrotic patients, diabetics, and ESRD patients will be presented and discussed. It is reasonable to hypothesize that proteolytic fragmentation of serum albumin is due to a higher susceptibility to proteases, induced by oxidative stress. The clinical relevance of the fragmentation of albumin has not yet been established. These modifications could affect some physiological functions of albumin and have a patho-physiological role in uremic syndrome. Proteomic analysis of serum allows the identification of over-expressed proteins and can detect post-translational modifications of serum proteins, hitherto hidden, using standard laboratory techniques. Copyright © 2011 Elsevier B.V. All rights reserved.

Final Hazard Classification and Auditable Safety Analysis for the 105-F Building Interim Safe Storage Project

International Nuclear Information System (INIS)

Rodovsky, T.J.; Bond, S.L.

1998-07-01

The auditable safety analysis (ASA) documents the authorization basis for the partial decommissioning and facility modifications to place the 105-F Building into interim safe storage (ISS). Placement into the ISS is consistent with the preferred alternative identified in the Record of Decision (58 FR). Modifications will reduce the potential for release and worker exposure to hazardous and radioactive materials, as well as lower surveillance and maintenance (S ampersand M) costs. This analysis includes the following: A description of the activities to be performed in the course of the 105-F Building ISS Project. An assessment of the inventory of radioactive and other hazardous materials within the 105-F Building. Identification of the hazards associated with the activities of the 105-F Building ISS Project. Identification of internally and externally initiated accident scenarios with the potential to produce significant local or offsite consequences during the 105-F Building ISS Project. Bounding evaluation of the consequences of the potentially significant accident scenarios. Hazard classification based on the bounding consequence evaluation. Associated safety function and controls, including commitments. Radiological and other employee safety and health considerations

An Interdisciplinary Meta-Analysis of the Potential Antecedents, Correlates, and Consequences of Protege Perceptions of Mentoring

Science.gov (United States)

Eby, Lillian Turner de Tormes; Allen, Tammy D.; Hoffman, Brian J.; Baranik, Lisa E.; Sauer, Julia B.; Baldwin, Sean; Morrison, M. Ashley; Kinkade, Katie M.; Maher, Charleen P.; Curtis, Sara; Evans, Sarah C.

2013-01-01

This meta-analysis summarized youth, academic, and workplace research on the potential antecedents (demographics, human capital, and relationship attributes), correlates (interaction frequency, relationship length, performance, motivation, and social capital), and consequences (attitudinal, behavioral, career-related, and health-related outcomes)…

A structural modification of the two dimensional fuel behaviour analysis code FEMAXI-III with high-speed vectorized operation

International Nuclear Information System (INIS)

Yanagisawa, Kazuaki; Ishiguro, Misako; Yamazaki, Takashi; Tokunaga, Yasuo.

1985-02-01

Though the two-dimensional fuel behaviour analysis code FEMAXI-III has been developed by JAERI in form of optimized scalar computer code, the call for more efficient code usage generally arized from the recent trends like high burn-up and load follow operation asks the code into further modification stage. A principal aim of the modification is to transform the already implemented scalar type subroutines into vectorized forms to make the programme structure efficiently run on high-speed vector computers. The effort of such structural modification has been finished on a fair way to success. The benchmarking two tests subsequently performed to examine the effect of the modification led us the following concluding remarks: (1) In the first benchmark test, comparatively high-burned three fuel rods that have been irradiated in HBWR, BWR, and PWR condition are prepared. With respect to all cases, a net computing time consumed in the vectorized FEMAXI is approximately 50 % less than that consumed in the original one. (2) In the second benchmark test, a total of 26 PWR fuel rods that have been irradiated in the burn-up ranges of 13-30 MWd/kgU and subsequently power ramped in R2 reactor, Sweden is prepared. In this case the code is purposed to be used for making an envelop of PCI-failure threshold through 26 times code runs. Before coming to the same conclusion, the vectorized FEMAXI-III consumed a net computing time 18 min., while the original FEMAXI-III consumed a computing time 36 min. respectively. (3) The effects obtained from such structural modification are found to be significantly attributed to saving a net computing time in a mechanical calculation in the vectorized FEMAXI-III code. (author)

Unrestricted Mass Spectrometric Data Analysis for Identification, Localization, and Quantification of Oxidative Protein Modifications

DEFF Research Database (Denmark)

Rykær, Martin; Svensson, Birte; Davies, Michael J

2017-01-01

modifications based on so-called "dependent peptides". The strategy involves unrestricted database searches with rigorous filtering focusing on oxidative modifications. The approach was applied to bovine serum albumin and human serum proteins subjected to metal ion-catalyzed oxidation, resulting...

The Human Thioredoxin System: Modifications and Clinical Applications

Directory of Open Access Journals (Sweden)

Seyed Isaac Hashemy

2011-03-01

Full Text Available The thioredoxin system, comprising thioredoxin (Trx, thioredoxin reductase (TrxR and NADPH, is one of the major cellular antioxidant systems, implicated in a large and growing number of biological functions. Trx acts as an oxidoreductase via a highly conserved dithiol/disulfide motif located in the active site (-Trp-Cys-Gly-Pro-Cys-Lys-. Different factors are involved in the regulation of Trx activity, including its expression level, localization, protein-protein interactions, post-translational modifications and some chemical inhibitors. Mammalian TrxRs are selenoproteins which have a –Cys-Val-Asn-Val-Gly-Cys- N-terminal active site, as well as a C-terminal selenium-containing active site. Besides two Cys-residues in the redox-regulatory domain of cytosolic Trx (Trx1, human Trx1 has three additional Cys-residues. Post-translational modifications of human Trx1 which are involved in the regulation of its activity can happen via modification of Cys-residues including thiol oxidation, glutathionylation and S-nitrosylation or via modification of other amino acid residues such as nitration of Tyr-49. Because of the numerous functions of the thioredoxin system, its inhibition (mainly happens via the targeting TrxR can result in major cellular consequences, which are potentially pro-oxidant in nature, leading to cell death via necrosis or apoptosis if overexpression of Trx and other antioxidative enzymes can not recuperate cell response. Considering this feature, several anticancer drugs have been used which can inhibit TrxR. Elevated levels of Trx and/or TrxR have been reported in many different human malignancies, positively correlated with aggressive tumor growth and poor prognosis. Moreover, anti-oxidative and anti-apoptotic effects of Trx are reasons to study its clinical application as a drug.

The good, the bad, and the unknown about telecommuting: meta-analysis of psychological mediators and individual consequences.

Science.gov (United States)

Gajendran, Ravi S; Harrison, David A

2007-11-01

What are the positive and negative consequences of telecommuting? How do these consequences come about? When are these consequences more or less potent? The authors answer these questions through construction of a theoretical framework and meta-analysis of 46 studies in natural settings involving 12,883 employees. Telecommuting had small but mainly beneficial effects on proximal outcomes, such as perceived autonomy and (lower) work-family conflict. Importantly, telecommuting had no generally detrimental effects on the quality of workplace relationships. Telecommuting also had beneficial effects on more distal outcomes, such as job satisfaction, performance, turnover intent, and role stress. These beneficial consequences appeared to be at least partially mediated by perceived autonomy. Also, high-intensity telecommuting (more than 2.5 days a week) accentuated telecommuting's beneficial effects on work-family conflict but harmed relationships with coworkers. Results provide building blocks for a more complete theoretical and practical treatment of telecommuting. (c) 2007 APA

PSA effect analysis of a design modification of the auxiliary feedwater system for a Westinghouse type plant

International Nuclear Information System (INIS)

Bae, Yeon Kyoung; Lee, Eun Chan

2012-01-01

The auxiliary feedwater system is an important system used to mitigate most accidents considered in probabilistic safety assessment (PSA). The reference plant has produced electric power for about thirty years. Due to age related deterioration and lack of parts, a turbine driven auxiliary feedwater pump (TD AFWP), some valves, and piping of the auxiliary feedwater system should be replaced. This change includes relocation of some valves, installation of valves for maintenance of the steam generator, and a new cross tie line. According to the design change, the Final Safety Analysis Report (FSAR) has been revised. Therefore, this design modification affects the PSA. It is thus necessary to assess the improvement of plant safety. In this paper, the impact of the design change of the auxiliary feedwater system on the PSA is assessed. The results demonstrate that this modification considering the plant safety decreased the total CDF

Modification of an x-ray diffraction unit to comply with the NH and MRC code of practice

International Nuclear Information System (INIS)

Ibbetson, V.J.; Young, J.G.

2004-01-01

X-ray analysis units are commonly used in research and industrial laboratories throughout Australia. Despite a well-established Code of Practice and working protocols for the safe use of such units, there are all too many stories of users by-passing safety features significantly increasing the risk of accidental exposure to the primary X-ray beam. Since the output of such units may be as high as 300 Gy x s 1 , such accidental exposures could have very serious consequences. Australian Radiation Services Pty Ltd undertook a compliance audit of an X-ray diffraction unit with respect to the NH and MRC Code of Practice for protection against ionising radiation emitted from X-ray analysis equipment. This paper discusses the findings from the initial inspection and the modifications recommended for the XRD unit to ensure compliance with the Code, without unnecessarily restricting its use. Copyright (2004) Australasian Radiation Protection Society Inc

College Alcohol Beliefs and Drinking Consequences: A Multiple Mediation Analysis of Norms, Expectancies, and Willingness to Experience Drinking Consequences

Science.gov (United States)

Osberg, Timothy M.; Boyer, Amber

2018-01-01

Objective: We explored the potential mediating role of willingness to experience drinking consequences and other traditional alcohol outcome predictors (descriptive norms, injunctive norms, positive alcohol expectancies) in explaining the association between college alcohol beliefs1 (CABs) and the actual experience of drinking consequences among…

The continual fuel management modification in Qinshan project II

International Nuclear Information System (INIS)

Ye Guodong; Pan Zefei; Zhang Xingtian

2010-01-01

The fuel management strategy is the basis of the nuclear power plants. The performance of the fuel management strategy affects the plants' safety and economy indicators directly. The paper summarizes all the modifications on the fuel management work in Qinshan Project II since the plant was established. It includes the surveillance system of physics tests, fetching in high performance fuel assemblies, reloading pattern optimization, and the modifications of the final safety analysis report. At the same time, it evaluates the benefit of the modifications in the few years. The experience in this paper is much helpful and could be implemented on the same type plants. (authors)

Modifications Of Discrete Ordinate Method For Computations With High Scattering Anisotropy: Comparative Analysis

Science.gov (United States)

Korkin, Sergey V.; Lyapustin, Alexei I.; Rozanov, Vladimir V.

2012-01-01

A numerical accuracy analysis of the radiative transfer equation (RTE) solution based on separation of the diffuse light field into anisotropic and smooth parts is presented. The analysis uses three different algorithms based on the discrete ordinate method (DOM). Two methods, DOMAS and DOM2+, that do not use the truncation of the phase function, are compared against the TMS-method. DOMAS and DOM2+ use the Small-Angle Modification of RTE and the single scattering term, respectively, as an anisotropic part. The TMS method uses Delta-M method for truncation of the phase function along with the single scattering correction. For reference, a standard discrete ordinate method, DOM, is also included in analysis. The obtained results for cases with high scattering anisotropy show that at low number of streams (16, 32) only DOMAS provides an accurate solution in the aureole area. Outside of the aureole, the convergence and accuracy of DOMAS, and TMS is found to be approximately similar: DOMAS was found more accurate in cases with coarse aerosol and liquid water cloud models, except low optical depth, while the TMS showed better results in case of ice cloud.

Reinforcement of Defence-in-Depth: Modification Practice After the Fukushima Nuclear Accident

Energy Technology Data Exchange (ETDEWEB)

Wang, Y.; Tang, H.; Mao, Q., E-mail: wangyuhong@cgnpc.com.cn [China Nuclear Power Design Co., Ltd Xia Meilin, Futian District, Shenzhen, Guangdong Province (China)

2014-10-15

The Fukushima Daiichi nuclear accident revealed the importance and demand for further reinforcement of defence in- depth. CGN (China General Nuclear Power Group) has made a complete safety assessment on CPR1000 nuclear power plants under construction in China. Dozens of modifications have been implemented based on the assessment findings and lessons learned from Fukushima nuclear accident, taking into account of PSA (Probabilistic Safety Analysis) and comparison analysis of the latest regulations and standards. These modifications help to enhance nuclear safety significantly for nuclear power plants under construction in China, and provide helpful modification guidance for nuclear power plants in operation of the same type. (author)

Quantitative Analysis and Efficient Surface Modification of Silica Nanoparticles

Directory of Open Access Journals (Sweden)

Hak-Sung Jung

2012-01-01

Full Text Available Aminofunctional trialkoxysilanes such as aminopropyltrimethoxysilane (APTMS and (3-trimethoxysilylpropyldiethylenetriamine (DETAS were employed as a surface modification molecule for generating monolayer modification on the surface of silica (SiO2 nanoparticles. We were able to quantitatively analyze the number of amine functional groups on the modified SiO2 nanoparticles by acid-base back titration method and determine the effective number of amine functional groups for the successive chemical reaction by absorption measurements after treating with fluorescent rhodamine B isothiocyanate (RITC molecules. The numbers of amine sites measured by back titration were 2.7 and 7.7 ea/nm2 for SiO2-APTMS and SiO2-DETAS, respectively, while the numbers of effective amine sites measured by absorption calibration were about one fifth of the total amine sites, namely, 0.44 and 1.3 ea/nm2 for SiO2-APTMS(RITC and SiO2-DETAS(RITC, respectively. Furthermore, it was confirmed that the reactivity of amino groups on the surface-modified silica nanoparticles could be maintained in ethanol for more than 1.5 months without showing any significant differences in the reactivity.

A Consequence Analysis of the Explosion of Spherical Tanks Containing Liquefied Petroleum Gas (LPG

Directory of Open Access Journals (Sweden)

Hadi Zareei

2016-07-01

Full Text Available A consequence analysis was performed in one of the gas refineries in Iran to investigate the risks andpotential losses resulted from accidents. Specifically, the consequences of an explosion in LPGspherical tanks were modeled using PHAST and MATLAB software. In this paper, three methods ofcalculation of PHAST software TNT, multi-energy, and BST were used. The results showed thatmulti energy method is the best method to evaluate overpressure. It was 0.150 bar and 0.159 bar in adistance of 1000 m far from the blast using PHAST and MATLAB respectively. This overpressurecan damage a wall with 30 cm thickness. It also affects the human threshold (1% ruptured eardrum.Finally, it was found that 100% lethality in a minute happened at 285.5 m and 37.5 kW/m2 when theexplosion happened.

Estradiol protective role in atherogenesis through LDL structure modification

International Nuclear Information System (INIS)

Papi, Massimiliano; Ciasca, Gabriele; Maiorana, Alessandro; Maulucci, Giuseppe; Palmieri, Valentina; De Spirito, Marco; Brunelli, Roberto; Parasassi, Tiziana

2016-01-01

Relevant physiological functions are exerted by circulating low density lipoprotein (LDL) as well as eventual pathological processes triggering atherogenesis. Modulation of these functions can well be founded on modifications of LDL structure. Given its large dimension, multicomponent organization and strong interactions between the protein apoB-100 and lipids, determining LDL 3D structure remains a challenge. We propose a novel quantitative physical approach to this complex biological problem. We introduce a three-component model, fitted to small angle x-ray scattering data on LDL maintained in physiological conditions, able to achieve a consistent 3D structure. Unexpected features include three distinct protein domains protruding out of a sphere, quite rough in its surface, where several core lipid areas are exposed. All LDL components are affected by 17- β -estradiol (E2) binding to apoB-100. Mostly one of the three protruding protein domains, dramatically reducing its presence on the surface and with a consequent increase of core lipids’ exposure. This result suggests a structural basis for some E2 protecting roles and LDL physiological modifications. (paper)

Offsite radiological consequence analysis for the bounding aircraft crash accident

International Nuclear Information System (INIS)

OBERG, B.D.

2003-01-01

The purpose of this calculation note is to quantitatively analyze a bounding aircraft crash accident for comparison to the DOE-STD-3009-94, ''Preparation Guide for U.S. Department of Energy Nonreactor Nuclear Facility Documented Safety Analyses'', Appendix A, Evaluation Guideline of 25 rem. The potential of aircraft impacting a facility was evaluated using the approach given in DOE-STD-3014-96, ''Accident Analysis for Aircraft Crash into Hazardous Facilities''. The following aircraft crash FR-equencies were determined for the Tank Farms in RPP-11736, ''Assessment Of Aircraft Crash FR-equency For The Hanford Site 200 Area Tank Farms'': (1) The total aircraft crash FR-equency is ''extremely unlikely.'' (2) The general aviation crash FR-equency is ''extremely unlikely.'' (3) The helicopter crash FR-equency is ''beyond extremely unlikely.'' (4) For the Hanford Site 200 Areas, other aircraft type, commercial or military, each above ground facility, and any other type of underground facility is ''beyond extremely unlikely.'' As the potential of aircraft crash into the 200 Area tank farms is more FR-equent than ''beyond extremely unlikely,'' consequence analysis of the aircraft crash is required

Unintended Consequences of Wearable Sensor Use in Healthcare. Contribution of the IMIA Wearable Sensors in Healthcare WG.

Science.gov (United States)

Schukat, M; McCaldin, D; Wang, K; Schreier, G; Lovell, N H; Marschollek, M; Redmond, S J

2016-11-10

As wearable sensors take the consumer market by storm, and medical device manufacturers move to make their devices wireless and appropriate for ambulatory use, this revolution brings with it some unintended consequences, which we aim to discuss in this paper. We discuss some important unintended consequences, both beneficial and unwanted, which relate to: modifications of behavior; creation and use of big data sets; new security vulnerabilities; and unforeseen challenges faced by regulatory authorities, struggling to keep pace with recent innovations. Where possible, we proposed potential solutions to unwanted consequences. Intelligent and inclusive design processes may mitigate unintended modifications in behavior. For big data, legislating access to and use of these data will be a legal and political challenge in the years ahead, as we trade the health benefits of wearable sensors against the risk to our privacy. The wireless and personal nature of wearable sensors also exposes them to a number of unique security vulnerabilities. Regulation plays an important role in managing these security risks, but also has the dual responsibility of ensuring that wearable devices are fit for purpose. However, the burden of validating the function and security of medical devices is becoming infeasible for regulators, given the many software apps and wearable sensors entering the market each year, which are only a subset of an even larger 'internet of things'. Wearable sensors may serve to improve wellbeing, but we must be vigilant against the occurrence of unintended consequences. With collaboration between device manufacturers, regulators, and end-users, we balance the risk of unintended consequences occurring against the incredible benefit that wearable sensors promise to bring to the world.

Quantitative Analysis of MicroRNAs in Vaccinia virus Infection Reveals Diversity in Their Susceptibility to Modification and Suppression.

Directory of Open Access Journals (Sweden)

Amy H Buck

Full Text Available Vaccinia virus (VACV is a large cytoplasmic DNA virus that causes dramatic alterations to many cellular pathways including microRNA biogenesis. The virus encodes a poly(A polymerase which was previously shown to add poly(A tails to the 3' end of cellular miRNAs, resulting in their degradation by 24 hours post infection (hpi. Here we used small RNA sequencing to quantify the impact of VACV infection on cellular miRNAs in human cells at both early (6 h and late (24 h times post infection. A detailed quantitative analysis of individual miRNAs revealed marked diversity in the extent of their modification and relative change in abundance during infection. Some miRNAs became highly modified (e.g. miR-29a-3p, miR-27b-3p whereas others appeared resistant (e.g. miR-16-5p. Furthermore, miRNAs that were highly tailed at 6 hpi were not necessarily among the most reduced at 24 hpi. These results suggest that intrinsic features of human cellular miRNAs cause them to be differentially polyadenylated and altered in abundance during VACV infection. We also demonstrate that intermediate and late VACV gene expression are required for optimal repression of some miRNAs including miR-27-3p. Overall this work reveals complex and varied consequences of VACV infection on host miRNAs and identifies miRNAs which are largely resistant to VACV-induced polyadenylation and are therefore present at functional levels during the initial stages of infection and replication.

A joint analysis of determinants and performance consequences of ambidexterity

OpenAIRE

Eva M. Pertusa-Ortega; José F. Molina-Azorín

2018-01-01

Summary: This paper simultaneously analyzes antecedents and consequences of organizational ambidexterity. Regarding antecedents, the paper examines the influence of internal antecedents (organizational structure) and external antecedents (environmental dynamism). With regard to consequences, the paper analyzes the impact of ambidexterity on firm performance. Moreover, we use two different approaches to ambidexterity (structural and contextual perspectives). The findings show that a hybrid org...

Epigenetic Consequences of Low Birth-Weight and Preterm Birth in Adult Twins

DEFF Research Database (Denmark)

Tan, Qihua

2018-01-01

could be detrimental to health later in life. Current epigenetic studies using genome-wide DNA methylation profiling have discovered molecular evidence confirming that, as important early life events, both low birth-weight and premature birth can result in long-lasting epigenetic consequences...... that impact health at adult ages. Results from our epigenome-wide association studies indicate that the two moderately correlated traits of adverse pregnancy outcome could be linked to increased susceptibility to different health problems with low birth-weight more relevant to metabolic disorders, while......Adverse birth outcomes including low birth-weight and preterm birth are associated with long-term morbidity and health consequences at adult ages. Molecular mechanisms including epigenetic modification may have been involved in the adaptation to the stressful condition in peridelivery period which...

Tank Bump Accident Potential and Consequences During Waste Retrieval

International Nuclear Information System (INIS)

BRATZEL, D.R.

2000-01-01

This report provides an evaluation of Hanford tank bump accident potential and consequences during waste retrieval operations. The purpose of this report is to consider the best available new information to support recommendations for safety controls. A new tank bump accident analysis for safe storage (Epstein et al. 2000) is extended for this purpose. A tank bump is a postulated event in which gases, consisting mostly of water vapor, are suddenly emitted from the waste and cause tank headspace pressurization. Tank bump scenarios, physical models, and frequency and consequence methods are fully described in Epstein et al. (2000). The analysis scope is waste retrieval from double-shell tanks (DSTs) including operation of equipment such as mixer pumps and air lift circulators. The analysis considers physical mechanisms for tank bump to formulate criteria for bump potential during retrieval, application of the criteria to the DSTs, evaluation of bump frequency, and consequence analysis of a bump. The result of the consequence analysis is the mass of waste released from tanks; radiological dose is calculated using standard methods (Cowley et al. 2000)

Plasma polymerization surface modification of Carbon black and its effect in elastomers

NARCIS (Netherlands)

Mathew, T.; Datta, Rabin; Dierkes, Wilma K.; Talma, Auke; Ooij, W.J.; Noordermeer, Jacobus W.M.

2011-01-01

Surface modification of carbon black by plasma polymerization was aimed to reduce its surface energy in order to compatibilize the filler with various elastomers. A fullerenic carbon black was used for the modification process. Thermogravimetric analysis, wetting behavior with liquids of known

Turbulence modification due to bubbles and particles in dispersed two-phase upflows in a vertical pipe

International Nuclear Information System (INIS)

Hosokawa, Shigeo; Tomiyama, Akio

1999-01-01

One of the key issues in two-phase turbulence modeling is the turbulence modification due to the momentum exchange between the dispersed and continuous phases. As for the gas-liquid two-phase flows in vertical pipes, Serizawa and Kataoka carried out detailed measurement of turbulence intensity and detected the turbulence modification. Gore and Crowe pointed out that the modification is well correlated with the ratio of a particle diameter to a turbulence length scale (d/l t ). However the modification may depend on not only the length scales but also the eddy viscosities of shear-induced and particle-induced turbulence. Hosokawa et al. proposed the ratio φ of the eddy viscosity induced by a dispersed phase to the shear-induced eddy viscosity and confirmed that measured turbulence modification was well correlated with φ for a gas-solid two-phase flow. In this study, we examine whether or not φ is also applicable to gas-liquid and solid-liquid two-phase dispersed upflows in vertical pipes. Using the eddy viscosity ratio instead of d/l t , we could obtain much better correlation. The critical point at which no modification occurred was close to φ = 1, irrespective of a type of a two-phase dispersed flow. Consequently, we could confirm that the eddy viscosity ratio is a more appropriate parameter for correlating the turbulent modification than the conventional critical parameter d/l t . (author)

A radiological consequence analysis with HEU and LEU fuels

International Nuclear Information System (INIS)

Woodruff, W.L.; Warinner, D.K.; Matos, J.E.

1985-01-01

A model for estimating the radiological consequences from a hypothetical accident in HEU and LEU fueled research and test reactors is presented. Simple hand calculations based on fission product yield table inventories and nonsite specific dispersion data may be adequate in many cases. However, more detailed inventories and site specific data on meteorological conditions and release rates and heights can result in substantial reductions in the dose estimates. LEU fuel gives essentially the same doses as HEU fuel. The plutonium buildup in the LEU fuel does not significantly increase the radiological consequences. The dose to the thyroid is the limiting dose. (author)

Modification of leaf morphology and anatomy as a consequence of columnar architecture in domestic apple (Malus x domestica Borkh.) trees

DEFF Research Database (Denmark)

Talwara, Susheela; Grout, Brian William Wilson; Toldam-Andersen, Torben Bo

2013-01-01

A quantitative study has been made of the modifications to leaf morphology and anatomy evident in columnar apples trees when compared to standard ones, using the original cultivar and the first columnar mutant derived from it, as well as other closely and more distantly related cultivars. Signifi......A quantitative study has been made of the modifications to leaf morphology and anatomy evident in columnar apples trees when compared to standard ones, using the original cultivar and the first columnar mutant derived from it, as well as other closely and more distantly related cultivars....... Significant increases in leaf number, area, weight per unit area, thickness and midrib angle, together with altered shape, have been recorded consistently for the leaves subtending the developing fruits of the columnar cultivars. Additionally, significant increases in leaf rolling, epicuticular wax, stomatal...... of leaf characteristics is considered in terms of the very open architectural phenotype of columnar trees and the impact this may have on the canopy microclimate that influences leaf development....

N-terminal modifications of cellular proteins: The enzymes involved, their substrate specificities and biological effects

Science.gov (United States)

Varland, Sylvia; Osberg, Camilla; Arnesen, Thomas

2015-01-01

The vast majority of eukaryotic proteins are N-terminally modified by one or more processing enzymes. Enzymes acting on the very first amino acid of a polypeptide include different peptidases, transferases, and ligases. Methionine aminopeptidases excise the initiator methionine leaving the nascent polypeptide with a newly exposed amino acid that may be further modified. N-terminal acetyl-, methyl-, myristoyl-, and palmitoyltransferases may attach an acetyl, methyl, myristoyl, or palmitoyl group, respectively, to the α-amino group of the target protein N-terminus. With the action of ubiquitin ligases, one or several ubiquitin molecules are transferred, and hence, constitute the N-terminal modification. Modifications at protein N-termini represent an important contribution to proteomic diversity and complexity, and are essential for protein regulation and cellular signaling. Consequently, dysregulation of the N-terminal modifying enzymes is implicated in human diseases. We here review the different protein N-terminal modifications occurring co- or post-translationally with emphasis on the responsible enzymes and their substrate specificities. PMID:25914051

Structural consequences of carbon taxes: An input-output analysis

International Nuclear Information System (INIS)

Che Yuhu.

1992-01-01

A model system is provided for examining for examining the structural consequences of carbon taxes on economic, energy, and environmental issues. The key component is the Iterative Multi-Optimization (IMO) Process model which describes, using an Input-Output (I-O) framework, the feedback between price changes and substitution. The IMO process is designed to assure this feedback process when the input coefficients in an I-O table can be changed while holding the I-O price model. The theoretical problems of convergence to a limit in the iterative process and uniqueness (which requires all IMO processes starting from different initial prices to converge to a unique point for a given level of carbon taxes) are addressed. The empirical analysis also examines the effects of carbon taxes on the US economy as described by a 78 sector I-O model. Findings are compared with those of other models that assess the effects of carbon taxes, and the similarities and differences with them are interpreted in terms of differences in the scope, sectoral detail, time frame, and policy assumptions among the models

Energy sector from 1990 to 2005 - analysis and consequences

International Nuclear Information System (INIS)

Granic, G.

2005-01-01

The paper analyzes the energy sector in the period from 1990 to 2005. What is shown here through an analysis of political, economic, energy, technological and institutional processes, and based on actual developments and non-developments, the consequences on energy situation to be evolved in the next 15 years, are analyzed. A crucial characteristic of this period is the fact that consumption growth is more distant from the trends in the developed countries and is increasingly approaching ones occurring in developing and undeveloped countries. The other such characteristic is lack of technological progress, which could generate desirable structural changes in energy production and demand. Taking in consideration what has been accomplished so far and what has not been accomplished, we cannot expect in the coming period the changes that could significantly modify the relations in the structure of energy production and demand. Keeping the balance between production and demand will be increasingly difficult, as well as keeping the influence on energy prices which will be growing. In this, it is more than ever indispensable that the state takes up its role.(author)

Identification and Interrogation of Combinatorial Histone Modifications

Directory of Open Access Journals (Sweden)

Kelly R Karch

2013-12-01

Full Text Available Histone proteins are dynamically modified to mediate a variety of cellular processes including gene transcription, DNA damage repair, and apoptosis. Regulation of these processes occurs through the recruitment of non-histone proteins to chromatin by specific combinations of histone post-translational modifications (PTMs. Mass spectrometry has emerged as an essential tool to discover and quantify histone PTMs both within and between samples in an unbiased manner. Developments in mass spectrometry that allow for characterization of large histone peptides or intact protein has made it possible to determine which modifications occur simultaneously on a single histone polypeptide. A variety of techniques from biochemistry, biophysics, and chemical biology have been employed to determine the biological relevance of discovered combinatorial codes. This review first describes advancements in the field of mass spectrometry that have facilitated histone PTM analysis and then covers notable approaches to probe the biological relevance of these modifications in their nucleosomal context.

FEATUREOUS: AN INTEGRATED ENVIRONMENT FOR FEATURE-CENTRIC ANALYSIS AND MODIFICATION OF OBJECT-ORIENTED SOFTWARE

DEFF Research Database (Denmark)

Olszak, Andrzej; Jørgensen, Bo Nørregaard

2011-01-01

The decentralized nature of collaborations between objects in object-oriented software makes it difficult to understand the implementations of user-observable program features and their respective interdependencies. As feature-centric program understanding and modification are essential during...... software maintenance and evolution, this situation needs to change. In this paper, we present Featureous, an integrated development environment built on top of the NetBeans IDE that facilitates feature-centric analysis of object-oriented software. Our integrated development environment encompasses...... a lightweight feature location mechanism, a number of reusable analytical views, and necessary APIs for supporting future extensions. The base of the integrated development environment is a conceptual framework comprising of three complementary dimensions of comprehension: perspective, abstraction...

The Effectiveness of Cognitive Bias Modification Interventions for Substance Addictions: A Meta-Analysis

DEFF Research Database (Denmark)

Cristea, Ioana; Kok, Robin; Cuijpers, Pim

2016-01-01

Background and Aims Cognitive bias modification (CBM) interventions, presumably targeting automatic processes, are considered particularly promising for addictions. We conducted a meta-analysis examining randomized controlled trials (RCTs) of CBM for substance addiction outcomes. Methods Studies...... were identified through systematic searches in bibliographical databases. We included RCTs of CBM interventions, alone or in combination with other treatments, for any type of addiction. We examined trial risk of bias, publication bias and possible moderators. Effects sizes were computed for post......-test and follow-up, using a random-effects model. We grouped outcome measures and reported results for addiction (all related measures), craving and cognitive bias. Results We identified 25 trials, 18 for alcohol problems, and 7 for smoking. At post-test, there was no significant effect of CBM for addiction, g...

Effect of Aminosilane Modification on Nanocrystalline Cellulose Properties

Directory of Open Access Journals (Sweden)

Nurul Hanisah Mohd

2016-01-01

Full Text Available The application of renewable nanomaterials, like nanocrystalline cellulose (NCC, has recently been widely studied by many researchers. NCC has many benefits such as high aspect ratio, biodegradability, and high number of hydroxyl groups which offer great opportunities for modification. In this study, the NCC derived from empty fruit bunches (EFB was modified with aminosilane, 3-(2-aminoethylaminopropyl-dimethoxymethylsilane (AEAPDMS, and the characterization was performed to investigate the potential as carbon dioxide (CO2 capture. Modification of NCC with AEAPDMS was carried out in water/ethanol solvent (80/20 (v/v with a ratio of NCC to aminosilane of 1 : 1, 1 : 2, 1 : 3, and 1 : 4 w/w%. The effects of AEAPDMS on NCC were characterized using Fourier transform infrared (FTIR spectroscopy, thermogravimetric analysis (TGA, X-ray diffraction (XRD analysis, elemental analysis (CHNS, and transmission electron microscopy (TEM. The existence of AEAPDMS onto NCC was confirmed by ATR-FTIR spectroscopy as the new peaks of NH2 were bending and wagging, and Si-CH3 appeared. The thermal stability of NCC increased after modification due to the interaction with AEAPDMS. The elemental analysis result showed that the nitrogen content increased with an enhancement ratio of the modifiers. The XRD indicated that the crystallinity decreased while the rod-like geometry of NCC was maintained after amorphous AEAPDMS grafted on the NCC. Since AEAPDMS can be grafted on the NCC, the sample is applicable as CO2 capture.

Consequences of additional use of PET information for target volume delineation and radiotherapy dose distribution for esophageal cancer

International Nuclear Information System (INIS)

Muijs, Christina T.; Schreurs, Liesbeth M.; Busz, Dianne M.; Beukema, Jannet C.; Borden, Arnout J. van der; Pruim, Jan; Van der Jagt, Eric J.; Plukker, John Th.; Langendijk, Johannes A.

2009-01-01

Background and purpose: To determine the consequences of target volume (TV) modifications, based on the additional use of PET information, on radiation planning, assuming PET/CT-imaging represents the true extent of the tumour. Materials and methods: For 21 patients with esophageal cancer, two separate TV's were retrospectively defined based on CT (CT-TV) and co-registered PET/CT images (PET/CT-TV). Two 3D-CRT plans (prescribed dose 50.4 Gy) were constructed to cover the corresponding TV's. Subsequently, these plans were compared for target coverage, normal tissue dose-volume histograms and the corresponding normal tissue complication probability (NTCP) values. Results: The addition of PET led to the modification of CT-TV with at least 10% in 12 of 21 patients (57%) (reduction in 9, enlargement in 3). PET/CT-TV was inadequately covered by the CT-based treatment plan in 8 patients (36%). Treatment plan modifications resulted in significant changes (p < 0.05) in dose distributions to heart and lungs. Corresponding changes in NTCP values ranged from -3% to +2% for radiation pneumonitis and from -0.2% to +1.2% for cardiac mortality. Conclusions: This study demonstrated that TV's based on CT might exclude PET-avid disease. Consequences are under dosing and thereby possibly ineffective treatment. Moreover, the addition of PET in radiation planning might result in clinical important changes in NTCP.

On an efficient modification of singular value decomposition using independent component analysis for improved MRS denoising and quantification

International Nuclear Information System (INIS)

Stamatopoulos, V G; Karras, D A; Mertzios, B G

2009-01-01

An efficient modification of singular value decomposition (SVD) is proposed in this paper aiming at denoising and more importantly at quantifying more accurately the statistically independent spectra of metabolite sources in magnetic resonance spectroscopy (MRS). Although SVD is known in MRS applications and several efficient algorithms exist for estimating SVD summation terms in which the raw MRS data are analyzed, however, it would be more beneficial for such an analysis if techniques with the ability to estimate statistically independent spectra could be employed. SVD is known to separate signal and noise subspaces but it assumes orthogonal properties for the components comprising signal subspace, which is not always the case, and might impose heavy constraints for the MRS case. A much more relaxing constraint would be to assume statistically independent components. Therefore, a modification of the main methodology incorporating techniques for calculating the assumed statistically independent spectra is proposed by applying SVD on the MRS spectrogram through application of the short time Fourier transform (STFT). This approach is based on combining SVD on STFT spectrogram followed by an iterative application of independent component analysis (ICA). Moreover, it is shown that the proposed methodology combined with a regression analysis would lead to improved quantification of the MRS signals. An experimental study based on synthetic MRS signals has been conducted to evaluate the herein proposed methodologies. The results obtained have been discussed and it is shown to be quite promising

Assessment of modification level of hypoeutectic Al -Si alloys by pattern recognition of cooling curves

Directory of Open Access Journals (Sweden)

CHEN Xiang

2005-11-01

Full Text Available Most evaluations of modification level are done according to a specific scale based on an merican Foundry Society (AFS standard wall chart as qualitative analysis in Al-Si casting production currently. This method is quite dependent on human experience when making comparisons of the microstructure with the standard chart. And the structures depicted in the AFS chart do not always resemble those seen in actual Al-Si castings. Therefore, this ualitativeanalysis procedure is subjective and can introduce human-caused errors into comparative metallographic analyses. A quantization parameter of the modification level was introduced by setting up the relationship between mean area weighted shape factor of eutectic silicon phase and the modification level using image analysis technology. In order to evaluate the modification level, a new method called "intelligent evaluating of melt quality by pattern recognition of hermal analysis cooling curves" has also been introduced. The results show that silicon modification level can be precisely assessed by comparison of the cooling curve of the melt to be evaluated with the one most similar to it in a database.

Radiation effects on the parotid gland of mammals. Pt. 2. Modifications of plasma and parotid amylase activity

Energy Technology Data Exchange (ETDEWEB)

Balzi, M; Cremonini, D; Tomassi, I; Becciolini, A; Giannardi, G [Florence Univ. (Italy). Istituto di Radiologia; Pelu, G [I.N.R.C.A., Florence (Italy). Inst. of Radiology

1979-08-01

The early modifications of the activity of plasma and parotid amylase have been evaluated in rats after whole-body irradiation in different experimental conditions. The modifications observed in the rat are less evident than in humans. The results have shown an initial decrease and a subsequent increase appearing significant 74 hours after irradiation. This could be due to a direct action of ionizing radiation on the parotid glands. However we cannot exclude that the increase of ..cap alpha..-amylase could be determined by the intestinal radiation syndrome. In fact, this syndrome leads to a reduced food uptake, and consequently ..cap alpha..-amylase could accumulate in parotids.

Impact of magnetic shear modification on confinement and turbulent fluctuations in LHD plasmas

International Nuclear Information System (INIS)

Fukuda, T.; Tamura, N.; Ida, K.

2008-10-01

For the comprehensive understandings of transport phenomena in toroidal confinement systems and improvement of the predictive capability of burning plasmas in ITER, the impact of magnetic shear has been extensively investigated in the Large Helical Device (LHD) for comparison with tokamaks. Consequently, it was heuristically documented that the pronounced effect of magnetic shear, which has been hitherto considered to be ubiquitous and strongly impacts the core transport in the tokamak experiments, is not quite obvious. Namely, the kinetic profiles respond little under extensive modification of the magnetic shear in the core, although the local transport analysis indicates the sign of improvement in confinement transiently when the magnetic shear is reduced. It was thereby concluded that the magnetic shear in the core strongly influences the MHD activity, but it may only be one of the necessary conditions for the transport reduction, and some other crucial knobs, such as the density gradient or T e /T i ratio, would have to be simultaneously controlled. The low wavenumber turbulence seems to be suppressed under the weak shear, and the turbulent fluctuation intensity behaves in a consistent manner as a whole, following the conventional paradigm accumulated in the negative shear experiments in tokamaks. However, vigorous dynamics of turbulent fluctuations have occasionally been observed under the magnetic shear modification, which respond in much faster time scale than the characteristic time scale for either the magnetic diffusion or the profile evolution. (author)

Controller modification applied for active fault detection

DEFF Research Database (Denmark)

Niemann, Hans Henrik; Stoustrup, Jakob; Poulsen, Niels Kjølstad

2014-01-01

This paper is focusing on active fault detection (AFD) for parametric faults in closed-loop systems. This auxiliary input applied for the fault detection will also disturb the external output and consequently reduce the performance of the controller. Therefore, only small auxiliary inputs are used...... with the result that the detection and isolation time can be long. In this paper it will be shown, that this problem can be handled by using a modification of the feedback controller. By applying the YJBK-parameterization (after Youla, Jabr, Bongiorno and Kucera) for the controller, it is possible to modify...... the frequency for the auxiliary input is selected. This gives that it is possible to apply an auxiliary input with a reduced amplitude. An example is included to show the results....

Hypervelocity Impact Test Fragment Modeling: Modifications to the Fragment Rotation Analysis and Lightcurve Code

Science.gov (United States)

Gouge, Michael F.

2011-01-01

Hypervelocity impact tests on test satellites are performed by members of the orbital debris scientific community in order to understand and typify the on-orbit collision breakup process. By analysis of these test satellite fragments, the fragment size and mass distributions are derived and incorporated into various orbital debris models. These same fragments are currently being put to new use using emerging technologies. Digital models of these fragments are created using a laser scanner. A group of computer programs referred to as the Fragment Rotation Analysis and Lightcurve code uses these digital representations in a multitude of ways that describe, measure, and model on-orbit fragments and fragment behavior. The Dynamic Rotation subroutine generates all of the possible reflected intensities from a scanned fragment as if it were observed to rotate dynamically while in orbit about the Earth. This calls an additional subroutine that graphically displays the intensities and the resulting frequency of those intensities as a range of solar phase angles in a Probability Density Function plot. This document reports the additions and modifications to the subset of the Fragment Rotation Analysis and Lightcurve concerned with the Dynamic Rotation and Probability Density Function plotting subroutines.

Choice & Consequence

DEFF Research Database (Denmark)

Khan, Azam

to support hypothesis generation, hypothesis testing, and decision making. In addition to sensors in buildings, infrastructure, or the environment, we also propose the instrumentation of user interfaces to help measure performance in decision making applications. We show the benefits of applying principles...... between cause and effect in complex systems complicates decision making. To address this issue, we examine the central role that data-driven decision making could play in critical domains such as sustainability or medical treatment. We developed systems for exploratory data analysis and data visualization...... of data analysis and instructional interface design, to both simulation systems and decision support interfaces. We hope that projects such as these will help people to understand the link between their choices and the consequences of their decisions....

Risk-based input-output analysis of influenza epidemic consequences on interdependent workforce sectors.

Science.gov (United States)

Santos, Joost R; May, Larissa; Haimar, Amine El

2013-09-01

Outbreaks of contagious diseases underscore the ever-looming threat of new epidemics. Compared to other disasters that inflict physical damage to infrastructure systems, epidemics can have more devastating and prolonged impacts on the population. This article investigates the interdependent economic and productivity risks resulting from epidemic-induced workforce absenteeism. In particular, we develop a dynamic input-output model capable of generating sector-disaggregated economic losses based on different magnitudes of workforce disruptions. An ex post analysis of the 2009 H1N1 pandemic in the national capital region (NCR) reveals the distribution of consequences across different economic sectors. Consequences are categorized into two metrics: (i) economic loss, which measures the magnitude of monetary losses incurred in each sector, and (ii) inoperability, which measures the normalized monetary losses incurred in each sector relative to the total economic output of that sector. For a simulated mild pandemic scenario in NCR, two distinct rankings are generated using the economic loss and inoperability metrics. Results indicate that the majority of the critical sectors ranked according to the economic loss metric comprise of sectors that contribute the most to the NCR's gross domestic product (e.g., federal government enterprises). In contrast, the majority of the critical sectors generated by the inoperability metric include sectors that are involved with epidemic management (e.g., hospitals). Hence, prioritizing sectors for recovery necessitates consideration of the balance between economic loss, inoperability, and other objectives. Although applied specifically to the NCR, the proposed methodology can be customized for other regions. © 2012 Society for Risk Analysis.

Changes in Structural-Mechanical Properties and Degradability of Collagen during Aging-associated Modifications*

Science.gov (United States)

Panwar, Preety; Lamour, Guillaume; Mackenzie, Neil C. W.; Yang, Heejae; Ko, Frank; Li, Hongbin; Brömme, Dieter

2015-01-01

During aging, changes occur in the collagen network that contribute to various pathological phenotypes in the skeletal, vascular, and pulmonary systems. The aim of this study was to investigate the consequences of age-related modifications on the mechanical stability and in vitro proteolytic degradation of type I collagen. Analyzing mouse tail and bovine bone collagen, we found that collagen at both fibril and fiber levels varies in rigidity and Young's modulus due to different physiological changes, which correlate with changes in cathepsin K (CatK)-mediated degradation. A decreased susceptibility to CatK-mediated hydrolysis of fibrillar collagen was observed following mineralization and advanced glycation end product-associated modification. However, aging of bone increased CatK-mediated osteoclastic resorption by ∼27%, and negligible resorption was observed when osteoclasts were cultured on mineral-deficient bone. We observed significant differences in the excavations generated by osteoclasts and C-terminal telopeptide release during bone resorption under distinct conditions. Our data indicate that modification of collagen compromises its biomechanical integrity and affects CatK-mediated degradation both in bone and tissue, thus contributing to our understanding of extracellular matrix aging. PMID:26224630

An examination of the consequences in high consequence operations

Energy Technology Data Exchange (ETDEWEB)

Spray, S.D.; Cooper, J.A.

1996-06-01

Traditional definitions of risk partition concern into the probability of occurrence and the consequence of the event. Most safety analyses focus on probabilistic assessment of an occurrence and the amount of some measurable result of the event, but the real meaning of the ``consequence`` partition is usually afforded less attention. In particular, acceptable social consequence (consequence accepted by the public) frequently differs significantly from the metrics commonly proposed by risk analysts. This paper addresses some of the important system development issues associated with consequences, focusing on ``high consequence operations safety.``

Risk analysis of nuclear safeguards regulations

International Nuclear Information System (INIS)

Al-Ayat, R.A.; Altman, W.D.; Judd, B.R.

1982-06-01

The Aggregated Systems Model (ASM), a probabilisitic risk analysis tool for nuclear safeguards, was applied to determine benefits and costs of proposed amendments to NRC regulations governing nuclear material control and accounting systems. The objective of the amendments was to improve the ability to detect insiders attempting to steal large quantities of special nuclear material (SNM). Insider threats range from likely events with minor consequences to unlikely events with catastrophic consequences. Moreover, establishing safeguards regulations is complicated by uncertainties in threats, safeguards performance, and consequences, and by the subjective judgments and difficult trade-offs between risks and safeguards costs. The ASM systematically incorporates these factors in a comprehensive, analytical framework. The ASM was used to evaluate the effectiveness of current safeguards and to quantify the risk of SNM theft. Various modifications designed to meet the objectives of the proposed amendments to reduce that risk were analyzed. Safeguards effectiveness was judged in terms of the probability of detecting and preventing theft, the expected time to detection, and the expected quantity of SNM diverted in a year. Data were gathered in tours and interviews at NRC-licensed facilities. The assessment at each facility was begun by carefully selecting scenarios representing the range of potential insider threats. A team of analysts and facility managers assigned probabilities for detection and prevention events in each scenario. Using the ASM we computed the measures of system effectiveness and identified cost-effective safeguards modifications that met the objectives of the proposed amendments

Modifications to POISSON

International Nuclear Information System (INIS)

Harwood, L.H.

1981-01-01

At MSU we have used the POISSON family of programs extensively for magnetic field calculations. In the presently super-saturated computer situation, reducing the run time for the program is imperative. Thus, a series of modifications have been made to POISSON to speed up convergence. Two of the modifications aim at having the first guess solution as close as possible to the final solution. The other two aim at increasing the convergence rate. In this discussion, a working knowledge of POISSON is assumed. The amount of new code and expected time saving for each modification is discussed

Consequence and impact of electric utility industry restructuring on transient stability and small-signal stability analysis

International Nuclear Information System (INIS)

Vittal, V.

2000-01-01

The electric utility industry is undergoing unprecedented changes in its structure worldwide. With the advent of an open market environment and competition in the industry, and restructuring of the industry into separate generation, transmission, and distribution entities, new issues in power system operation and planning are inevitable. One of the major consequences of this new electric utility environment is the greater emphasis on reliability and secure operation of the power system. This paper examines the impact of restructuring on power system dynamic analysis. It specifically addresses issues related to transient stability analysis and small-signal stability analysis. Four major topics to examine the effect on the nature of studies conducted are considered. These topics are (1) system adequacy and security, (2) system modeling data requirements, (3) system protection and control, and (4) system restoration. The consequences and impact of each of these topics on the nature of the studies conducted are examined and discussed. The emphasis on greater reliability has led to a clearer enunciation of standards, measurements, and guides in some countries. These requirements will result in: (1) more measurements on existing systems, (2) rigorous analysis of transient stability and small-signal stability to determine operating limits and plan systems, (3) greater emphasis on studies to verify coordination and proper performance of protection and controls, and (4) development of a detailed plan for system restoration in the case of wide-spread outages

The IAEA transport regulations: main modifications included in the 1996 edition and the possible impact of its adoption in Argentina

International Nuclear Information System (INIS)

Lopez Vietri, J.R.; Novo, R.G.; Bianchi, A.J.

1998-01-01

Full text: This paper points out a comparative analysis between the requirements of the 1985 edition (as Amended 1990), in-force in almost all countries included Argentina, and the 1996 edition, that is foresee to put in-force 1st January 2001, of the Regulations for the safe transport of radioactive material, published by the International Atomic Energy Agency (IAEA). The English version of the 1996 edition was published in December 1996 and the Spanish one in September 1997. Such edition was the culmination of a difficult consensus and harmonisation reached after an analysis process of the-years cycle between the IAEA Member Sates and related international organisations (United Nations, International Civil Aviation Organisation, International Air Transport Association, International Federation of Air Lines Pilots Associations, International Maritime Organisation) as well as regional organisations (Economic Commission for Europe, Commission of the European Communities). Both editions of the Regulations include a set of design, operational and administrative requirements that substantially do not differ as for their safety basic philosophy. However, the 1996 edition introduces numerous modifications of different magnitude, which will derive in technological, economic and operative consequences. Of such modifications the paper only analysed the relevant ones which update the state of art in the subject and allow the Regulations continue maintaining an acceptable level of control of the radiation, criticality and thermal hazards to persons, property and the environment during the transport of radioactive material. In addition, the paper briefly describes the possible impact that the main modifications induced in the 1996 edition of the Regulations should have, depending on the type of user considered either in Argentina or in other Latin America countries. However, it is desirable that the personal of competent authorities of each country involved in transport

Health effects estimation code development for accident consequence analysis

International Nuclear Information System (INIS)

Togawa, O.; Homma, T.

1992-01-01

As part of a computer code system for nuclear reactor accident consequence analysis, two computer codes have been developed for estimating health effects expected to occur following an accident. Health effects models used in the codes are based on the models of NUREG/CR-4214 and are revised for the Japanese population on the basis of the data from the reassessment of the radiation dosimetry and information derived from epidemiological studies on atomic bomb survivors of Hiroshima and Nagasaki. The health effects models include early and continuing effects, late somatic effects and genetic effects. The values of some model parameters are revised for early mortality. The models are modified for predicting late somatic effects such as leukemia and various kinds of cancers. The models for genetic effects are the same as those of NUREG. In order to test the performance of one of these codes, it is applied to the U.S. and Japanese populations. This paper provides descriptions of health effects models used in the two codes and gives comparisons of the mortality risks from each type of cancer for the two populations. (author)

Disparity modifications and the emotional effects of stereoscopic images

Science.gov (United States)

Kawai, Takashi; Atsuta, Daiki; Tomiyama, Yuya; Kim, Sanghyun; Morikawa, Hiroyuki; Mitsuya, Reiko; Häkkinen, Jukka

2014-03-01

This paper describes a study that focuses on disparity changes in emotional scenes of stereoscopic (3D) images, in which an examination of the effects on pleasant and arousal was carried out by adding binocular disparity to 2D images that evoke specific emotions, and applying disparity modification based on the disparity analysis of famous 3D movies. From the results of the experiment, for pleasant, a significant difference was found only for the main effect of the emotions. On the other hand, for arousal, there was a trend of increasing the evaluation values in the order 2D condition, 3D condition and 3D condition applied the disparity modification for happiness, surprise, and fear. This suggests the possibility that binocular disparity and the modification affect arousal.

Probabilistic accident consequence uncertainty analysis: Dispersion and deposition uncertainty assessment. Volume 3, Appendices C, D, E, F, and G

Energy Technology Data Exchange (ETDEWEB)

Harper, F.T.; Young, M.L.; Miller, L.A. [Sandia National Labs., Albuquerque, NM (United States)] [and others

1995-01-01

The development of two new probabilistic accident consequence codes, MACCS and COSYMA, completed in 1990, estimate the risks presented by nuclear installations based on postulated frequencies and magnitudes of potential accidents. In 1991, the US Nuclear Regulatory Commission (NRC) and the Commission of the European Communities (CEC) began a joint uncertainty analysis of the two codes. The objective was to develop credible and traceable uncertainty distributions for the input variables of the codes. Expert elicitation, developed independently, was identified as the best technology available for developing a library of uncertainty distributions for the selected consequence parameters. The study was formulated jointly and was limited to the current code models and to physical quantities that could be measured in experiments. To validate the distributions generated for the wet deposition input variables, samples were taken from these distributions and propagated through the wet deposition code model along with the Gaussian plume model (GPM) implemented in the MACCS and COSYMA codes. Resulting distributions closely replicated the aggregated elicited wet deposition distributions. Project teams from the NRC and CEC cooperated successfully to develop and implement a unified process for the elaboration of uncertainty distributions on consequence code input parameters. Formal expert judgment elicitation proved valuable for synthesizing the best available information. Distributions on measurable atmospheric dispersion and deposition parameters were successfully elicited from experts involved in the many phenomenological areas of consequence analysis. This volume is the third of a three-volume document describing the project and contains descriptions of the probability assessment principles; the expert identification and selection process; the weighting methods used; the inverse modeling methods; case structures; and summaries of the consequence codes.

Probabilistic accident consequence uncertainty analysis: Dispersion and deposition uncertainty assessment. Volume 3, Appendices C, D, E, F, and G

International Nuclear Information System (INIS)

Harper, F.T.; Young, M.L.; Miller, L.A.

1995-01-01

The development of two new probabilistic accident consequence codes, MACCS and COSYMA, completed in 1990, estimate the risks presented by nuclear installations based on postulated frequencies and magnitudes of potential accidents. In 1991, the US Nuclear Regulatory Commission (NRC) and the Commission of the European Communities (CEC) began a joint uncertainty analysis of the two codes. The objective was to develop credible and traceable uncertainty distributions for the input variables of the codes. Expert elicitation, developed independently, was identified as the best technology available for developing a library of uncertainty distributions for the selected consequence parameters. The study was formulated jointly and was limited to the current code models and to physical quantities that could be measured in experiments. To validate the distributions generated for the wet deposition input variables, samples were taken from these distributions and propagated through the wet deposition code model along with the Gaussian plume model (GPM) implemented in the MACCS and COSYMA codes. Resulting distributions closely replicated the aggregated elicited wet deposition distributions. Project teams from the NRC and CEC cooperated successfully to develop and implement a unified process for the elaboration of uncertainty distributions on consequence code input parameters. Formal expert judgment elicitation proved valuable for synthesizing the best available information. Distributions on measurable atmospheric dispersion and deposition parameters were successfully elicited from experts involved in the many phenomenological areas of consequence analysis. This volume is the third of a three-volume document describing the project and contains descriptions of the probability assessment principles; the expert identification and selection process; the weighting methods used; the inverse modeling methods; case structures; and summaries of the consequence codes

Modification of surfaces and surface layers by non equilibrium processes

International Nuclear Information System (INIS)

Beamson, G.; Brennan, W.J.; Clark, D.T.; Howard, J.

1988-01-01

Plasmas are examples of non-equilibrium phenomena which are being used increasingly for the synthesis and modification of materials impossible by conventional routes. This paper introduces methods available by describing the construction and characteristics of some equipment used for the production of different types of plasmas and other non-equilibrium phenomena. This includes high energy ion beams. The special features, advantages and disadvantages of the techniques will be described. There are a multitude of potential application relevant to electronic, metallic, ceramic, and polymeric materials. However, scale-up from the laboratory to production equipment depends on establishing a better understanding of both the physics and chemistry of plasma as well as plasma-solid interactions. Examples are given of how such an understanding can be gained. The chemical analysis of polymer surfaces undergoing modification by inert gas, hydrogen or oxygen plasmas is shown to give physical information regarding the relative roles of diffusion of active species, and direct and radiative energy transfer from the plasma. Surface modification by plasma depositing a new material onto an existing substrate is discussed with particular reference to the deposition of amorphous carbon films. Applications of the unique properties of these films are outlined together with our current understanding of these properties based on chemical and physical methods of analysis of both the films and the plasmas producing them. Finally, surface modification by ion beams is briefly illustrated using examples from the electronics and metals industries where the modification has had a largely physical rather than chemical effect on the starting material. (orig.)

Evidence of Coal-Fly-Ash Toxic Chemical Geoengineering in the Troposphere: Consequences for Public Health.

Science.gov (United States)

Herndon, J Marvin

2015-08-11

The widespread, intentional and increasingly frequent chemical emplacement in the troposphere has gone unidentified and unremarked in the scientific literature for years. The author presents evidence that toxic coal combustion fly ash is the most likely aerosolized particulate sprayed by tanker-jets for geoengineering, weather-modification and climate-modification purposes and describes some of the multifold consequences on public health. Two methods are employed: (1) Comparison of 8 elements analyzed in rainwater, leached from aerosolized particulates, with corresponding elements leached into water from coal fly ash in published laboratory experiments, and (2) Comparison of 14 elements analyzed in dust collected outdoors on a high-efficiency particulate air (HEPA) filter with corresponding elements analyzed in un-leached coal fly ash material. The results show: (1) the assemblage of elements in rainwater and in the corresponding experimental leachate are essentially identical. At a 99% confidence interval, they have identical means (T-test) and identical variances (F-test); and (2) the assemblage of elements in the HEPA dust and in the corresponding average un-leached coal fly ash are likewise essentially identical. The consequences on public health are profound, including exposure to a variety of toxic heavy metals, radioactive elements, and neurologically-implicated chemically mobile aluminum released by body moisture in situ after inhalation or through transdermal induction.

Design basis event consequence analyses for the Yucca Mountain project

International Nuclear Information System (INIS)

Orvis, D.D.; Haas, M.N.; Martin, J.H.

1997-01-01

Design basis event (DBE) definition and analysis is an ongoing and integrated activity among the design and analysis groups of the Yucca Mountain Project (YMP). DBE's are those that potentially lead to breach of the waste package and waste form (e.g., spent fuel rods) with consequent release of radionuclides to the environment. A Preliminary Hazards Analysis (PHA) provided a systematic screening of external and internal events that were candidate DBE's that will be subjected to analyses for radiological consequences. As preparation, pilot consequence analyses for the repository subsurface and surface facilities have been performed to define the methodology, data requirements, and applicable regulatory limits

The Optimal Design Method and Standardized Mathematical Model of Tooth Profile Modification of Spur Gear

Directory of Open Access Journals (Sweden)

Wenjie Mei

2016-01-01

Full Text Available The paper reports a tooth profile modification method of spur gear. After establishing a standardized mathematical model for optimized tooth profile and simulating meshing process with ANSYS finite element analysis, we obtained 625 groups of gear models with different modification parameters. The group with minimum transmission errors owns the optimal parameters. Genetic algorithm was adopted in the entire process for the purpose of reducing the variation of transmission errors in meshing process. The arc and parabolic modification were doing the same processing. After comparing the transmission errors fluctuation produced by the meshing process of gear of nonmodification with arc modification and parabolic modification, we found that the best modification effects of arc modification and parabolic modification were both reduced by 90%. The modification method makes the gear drive process more stable and efficient, and it is also promising in general application for gear drive.

How to freak a Black & Mild: a multi-study analysis of YouTube videos illustrating cigar product modification.

Science.gov (United States)

Nasim, Aashir; Blank, Melissa D; Cobb, Caroline O; Berry, Brittany M; Kennedy, May G; Eissenberg, Thomas

2014-02-01

Cigar smoking is increasingly common among adolescents who perceive cigars as less harmful than cigarettes. This perception of reduced harm is especially true for cigars that are user-modified by removing the tobacco binder through a process called 'freaking'. Little is known about 'freaking' and this multi-study, mixed-methods analysis sought to understand better the rationale and prevailing beliefs about this smoking practice using YouTube videos. In Study 1, we conducted a descriptive content analysis on the characteristics of 26 randomly sampled cigar product modification (CPM) videos posted during 2006-10. In Study 2, a thematic analysis was performed on the transcripts of commentary associated with each video to characterize viewers' comments about video content. Study 1 results revealed that 90% of videos illustrated a four-step CPM technique: 'Loosening the tobacco'; 'Dumping the tobacco'; 'Removing the cigar binder' and 'Repacking the tobacco'. Four themes related to the purpose of CPM were also derived from video content: 'Easier to smoke' (54%), 'Beliefs in reduction of health risks' (31%), 'Changing the burn rate' (15%) and 'Taste enhancement' (12%). Study 2 results concerning the content characteristics of video comments were categorized into three themes: 'Disseminating information/answering questions' (81%), 'Seeking advice/asking questions' (69%) and 'Learning cigar modification techniques' (35%). Favorable comments were more common (81%) compared to unfavorable (58%) and comment content suggested low-risk perceptions and poor understanding of smoking harms. These findings highlight a novel means for youth to access information concerning CPM that may have important implications for tobacco control policy and prevention.

Strengthening, modification and repair techniques’ prioritization for structural integrity control of ageing offshore structures

International Nuclear Information System (INIS)

Samarakoon, Samindi M.K.; Ratnayake, R.M. Chandima

2015-01-01

Structural integrity control is vital for existing ageing as well as newly built offshore and onshore structures. Structural integrity control becomes highly sensitive to interventions under a potential loss of structural integrity when it comes to offshore oil and gas production and process facilities. This is mainly due to the inherent constraints present in carrying out engineering work in the offshore atmosphere. It has been further exacerbated by the ageing offshore structures and the necessity of carrying out life extension toward the end of their design service lives. Local and international regulations demand the implementation of appropriate strengthening, modification and repair plans when significant changes in the structural integrity are revealed. In this context, strengthening, modification and repair techniques such as welding, member removal/reduction of loading, mechanical clamping and grouted repairs play a vital role. This manuscript presents an approach for prioritizing the strengthening, modification and repair techniques using a multi-criteria analysis approach. An analytic hierarchy process has been selected for the analysis via an illustrative case. It also provides a comprehensive overview of currently existing; strengthening, modification and repair techniques and their comparative pros and cons. - Highlights: • Structural integrity control (SIC) of ageing and intact offshore structures. • Strengthening, modification and/or repair (SMR) techniques have been explained. • Application of multi-criteria analysis conserving SI has been illustrated. • SMR techniques prioritization and sensitivity analysis has been performed

Potential Indoor Worker Exposure From Handling Area Leakage: Dose Calculation Methodology and Example Consequence Analysis

International Nuclear Information System (INIS)

Nes, Razvan; Benke, Roland R.

2008-01-01

The U.S. Department of Energy (DOE) is currently considering design options for preclosure facilities in a license application for a geologic repository for spent nuclear fuel and high-level radioactive waste at Yucca Mountain, Nevada. The Center for Nuclear Waste Regulatory Analyses (CNWRA) developed the PCSA Tool Version 3.0.0 software for the U.S. Nuclear Regulatory Commission (NRC) to aid in the regulatory review of a potential DOE license application. The objective of this paper is to demonstrate PCSA Tool modeling capabilities (i.e., a generic two-compartment, mass-balance model) for estimating radionuclide concentrations in air and radiological dose consequences to indoor workers in a control room from potential leakage of radioactively contaminated air from an adjacent handling area. The presented model computes internal and external worker doses from inhalation and submersion in a finite cloud of contaminated air in the control room and augments previous capabilities for assessing indoor worker dose. As a complement to the example event sequence frequency analysis in the companion paper, example consequence calculations are presented in this paper for the postulated event sequence. In conclusion: this paper presents a model for estimating radiological doses to indoor workers for the leakage of airborne radioactive material from handling areas. Sensitivity of model results to changes in various input parameters was investigated via illustrative example calculations. Indoor worker dose estimates were strongly dependent on the duration of worker exposure and the handling-area leakage flow rate. In contrast, doses were not very sensitive to handling-area exhaust ventilation flow rates. For the presented example, inhalation was the dominant radiological dose pathway. The two companion papers demonstrate independent analysis capabilities of the regulator for performing confirmatory calculations of frequency and consequence, which assist the assessment of worker

Modification site localization scoring integrated into a search engine.

Science.gov (United States)

Baker, Peter R; Trinidad, Jonathan C; Chalkley, Robert J

2011-07-01

Large proteomic data sets identifying hundreds or thousands of modified peptides are becoming increasingly common in the literature. Several methods for assessing the reliability of peptide identifications both at the individual peptide or data set level have become established. However, tools for measuring the confidence of modification site assignments are sparse and are not often employed. A few tools for estimating phosphorylation site assignment reliabilities have been developed, but these are not integral to a search engine, so require a particular search engine output for a second step of processing. They may also require use of a particular fragmentation method and are mostly only applicable for phosphorylation analysis, rather than post-translational modifications analysis in general. In this study, we present the performance of site assignment scoring that is directly integrated into the search engine Protein Prospector, which allows site assignment reliability to be automatically reported for all modifications present in an identified peptide. It clearly indicates when a site assignment is ambiguous (and if so, between which residues), and reports an assignment score that can be translated into a reliability measure for individual site assignments.

Analysis of Histones H3 and H4 Reveals Novel and Conserved Post-Translational Modifications in Sugarcane.

Science.gov (United States)

Moraes, Izabel; Yuan, Zuo-Fei; Liu, Shichong; Souza, Glaucia Mendes; Garcia, Benjamin A; Casas-Mollano, J Armando

2015-01-01

Histones are the main structural components of the nucleosome, hence targets of many regulatory proteins that mediate processes involving changes in chromatin. The functional outcome of many pathways is "written" in the histones in the form of post-translational modifications that determine the final gene expression readout. As a result, modifications, alone or in combination, are important determinants of chromatin states. Histone modifications are accomplished by the addition of different chemical groups such as methyl, acetyl and phosphate. Thus, identifying and characterizing these modifications and the proteins related to them is the initial step to understanding the mechanisms of gene regulation and in the future may even provide tools for breeding programs. Several studies over the past years have contributed to increase our knowledge of epigenetic gene regulation in model organisms like Arabidopsis, yet this field remains relatively unexplored in crops. In this study we identified and initially characterized histones H3 and H4 in the monocot crop sugarcane. We discovered a number of histone genes by searching the sugarcane ESTs database. The proteins encoded correspond to canonical histones, and their variants. We also purified bulk histones and used them to map post-translational modifications in the histones H3 and H4 using mass spectrometry. Several modifications conserved in other plants, and also novel modified residues, were identified. In particular, we report O-acetylation of serine, threonine and tyrosine, a recently identified modification conserved in several eukaryotes. Additionally, the sub-nuclear localization of some well-studied modifications (i.e., H3K4me3, H3K9me2, H3K27me3, H3K9ac, H3T3ph) is described and compared to other plant species. To our knowledge, this is the first report of histones H3 and H4 as well as their post-translational modifications in sugarcane, and will provide a starting point for the study of chromatin regulation in

Radiological consequence analysis for upgradation of Pakistan Research Reactor-1 from 9 to 10 MW

International Nuclear Information System (INIS)

Khan, L.A.; Raza, S.S.

1993-12-01

Radiological consequence analysis has been carried out for upgradation of PARR-I from 9 to 10 MW. A hypothetical loss of coolant accident resulting in core meltdown and release of fission products to the atmosphere has been analyzed. Whole body and thyroid doses have been calculated as a function of time and distance from the containment building. Based on these dose estimates, boundaries of exclusion and low population zones are assessed. (author)

Examination of Conservatism in Ground-level Source Release Assumption when Performing Consequence Analysis

Energy Technology Data Exchange (ETDEWEB)

Kim, Sung-yeop; Lim, Ho-Gon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2015-10-15

One of these assumptions frequently assumed is the assumption of ground-level source release. The user manual of a consequence analysis software HotSpot is mentioning like below: 'If you cannot estimate or calculate the effective release height, the actual physical release height (height of the stack) or zero for ground-level release should be used. This will usually yield a conservative estimate, (i.e., larger radiation doses for all downwind receptors, etc).' This recommendation could be agreed in aspect of conservatism but quantitative examination of the effect of this assumption to the result of consequence analysis is necessary. The source terms of Fukushima Dai-ichi NPP accident have been estimated by several studies using inverse modeling and one of the biggest sources of the difference between the results of these studies was different effective source release height assumed by each studies. It supports the importance of the quantitative examination of the influence by release height. Sensitivity analysis of the effective release height of radioactive sources was performed and the influence to the total effective dose was quantitatively examined in this study. Above 20% difference is maintained even at longer distances, when we compare the dose between the result assuming ground-level release and the results assuming other effective plume height. It means that we cannot ignore the influence of ground-level source assumption to the latent cancer fatality estimations. In addition, the assumption of ground-level release fundamentally prevents detailed analysis including diffusion of plume from effective plume height to the ground even though the influence of it is relatively lower in longer distance. When we additionally consider the influence of surface roughness, situations could be more serious. The ground level dose could be highly over-estimated in short downwind distance at the NPP sites which have low surface roughness such as Barakah site in

Oxygenates in automotive fuels. Consequence analysis - preliminary study

International Nuclear Information System (INIS)

Brandberg, Aa.; Saevbark, B.

1994-01-01

Oxygenates is used in gasoline due to several reasons. They are added as high-octane components in unleaded gasoline and as agents to reduce the emission of harmful substances. Oxygenates produced from biomass might constitute a coming market for alternative fuels. This preliminary study describes the prerequisites and consequences of such an oxygenate utilization. 39 refs, 9 figs, 5 tabs

A joint analysis of determinants and performance consequences of ambidexterity

Directory of Open Access Journals (Sweden)

Eva M. Pertusa-Ortega

2018-04-01

Full Text Available Summary: This paper simultaneously analyzes antecedents and consequences of organizational ambidexterity. Regarding antecedents, the paper examines the influence of internal antecedents (organizational structure and external antecedents (environmental dynamism. With regard to consequences, the paper analyzes the impact of ambidexterity on firm performance. Moreover, we use two different approaches to ambidexterity (structural and contextual perspectives. The findings show that a hybrid organizational structure, with organic (decentralization and mechanistic characteristics (differentiation and formalization, and environmental dynamism, influence ambidexterity, and there is a positive impact of ambidexterity on firm performance. Keywords: Organizational ambidexterity, Structural approach, Contextual approach, Organizational structure, Environmental dynamism, Firm performance

Nuclear dynamics consequence analysis of SNF disposed in volcanic tuff

International Nuclear Information System (INIS)

Sanchez, L.C.; Cochrane, K.; Rath, J.S.; Taylor, L.L.

1998-05-01

This paper describes criticality analyses for spent nuclear fuels in a geologic repository. The analyses investigated criticality potential, criticality excursion consequences, and the probability frequency for nuclear criticality. Key findings include: expected number of fissions per excursion range from 10 17 to 10 20 , repeated rate of criticalities range from 3 to 30 per year, and the probability frequency for criticality initiators (based on rough-order-of-magnitude calculations) is 7x10 -7 . Overall results indicate that criticality consequences are a minor contribution to the biological hazards caused by the disposal of spent nuclear material

A cost-consequences analysis of a primary care librarian question and answering service.

Directory of Open Access Journals (Sweden)

Jessie McGowan

Full Text Available BACKGROUND: Cost consequences analysis was completed from randomized controlled trial (RCT data for the Just-in-time (JIT librarian consultation service in primary care that ran from October 2005 to April 2006. The service was aimed at providing answers to clinical questions arising during the clinical encounter while the patient waits. Cost saving and cost avoidance were also analyzed. The data comes from eighty-eight primary care providers in the Ottawa area working in Family Health Networks (FHNs and Family Health Groups (FHGs. METHODS: We conducted a cost consequences analysis based on data from the JIT project. We also estimated the potential economic benefit of JIT librarian consultation service to the health care system. RESULTS: The results show that the cost per question for the JIT service was $38.20. The cost could be as low as $5.70 per question for a regular service. Nationally, if this service was implemented and if family physicians saw additional patients when the JIT service saved them time, up to 61,100 extra patients could be seen annually. A conservative estimate of the cost savings and cost avoidance per question for JIT was $11.55. CONCLUSIONS: The cost per question, if the librarian service was used at full capacity, is quite low. Financial savings to the health care system might exceed the cost of the service. Saving physician's time during their day could potentially lead to better access to family physicians by patients. Implementing a librarian consultation service can happen quickly as the time required to train professional librarians to do this service is short.

Demonstration uncertainty/sensitivity analysis using the health and economic consequence model CRAC2

International Nuclear Information System (INIS)

Alpert, D.J.; Iman, R.L.; Johnson, J.D.; Helton, J.C.

1984-12-01

The techniques for performing uncertainty/sensitivity analyses compiled as part of the MELCOR program appear to be well suited for use with a health and economic consequence model. Two replicate samples of size 50 gave essentially identical results, indicating that for this case, a Latin hypercube sample of size 50 seems adequate to represent the distribution of results. Though the intent of this study was a demonstration of uncertainty/sensitivity analysis techniques, a number of insights relevant to health and economic consequence modeling can be gleaned: uncertainties in early deaths are significantly greater than uncertainties in latent cancer deaths; though the magnitude of the source term is the largest source of variation in estimated distributions of early deaths, a number of additional parameters are also important; even with the release fractions for a full SST1, one quarter of the CRAC2 runs gave no early deaths; and comparison of the estimates of mean early deaths for a full SST1 release in this study with those of recent point estimates for similar conditions indicates that the recent estimates may be significant overestimations of early deaths. Estimates of latent cancer deaths, however, are roughly comparable. An analysis of the type described here can provide insights in a number of areas. First, the variability in the results gives an indication of the potential uncertainty associated with the calculations. Second, the sensitivity of the results to assumptions about the input variables can be determined. Research efforts can then be concentrated on reducing the uncertainty in the variables which are the largest contributors to uncertainty in results

Cost-consequence analysis of different active flowable hemostatic matrices in cardiac surgical procedures.

Science.gov (United States)

Makhija, D; Rock, M; Xiong, Y; Epstein, J D; Arnold, M R; Lattouf, O M; Calcaterra, D

2017-06-01

A recent retrospective comparative effectiveness study found that use of the FLOSEAL Hemostatic Matrix in cardiac surgery was associated with significantly lower risks of complications, blood transfusions, surgical revisions, and shorter length of surgery than use of SURGIFLO Hemostatic Matrix. These outcome improvements in cardiac surgery procedures may translate to economic savings for hospitals and payers. The objective of this study was to estimate the cost-consequence of two flowable hemostatic matrices (FLOSEAL or SURGIFLO) in cardiac surgeries for US hospitals. A cost-consequence model was constructed using clinical outcomes from a previously published retrospective comparative effectiveness study of FLOSEAL vs SURGIFLO in adult cardiac surgeries. The model accounted for the reported differences between these products in length of surgery, rates of major and minor complications, surgical revisions, and blood product transfusions. Costs were derived from Healthcare Cost and Utilization Project's National Inpatient Sample (NIS) 2012 database and converted to 2015 US dollars. Savings were modeled for a hospital performing 245 cardiac surgeries annually, as identified as the average for hospitals in the NIS dataset. One-way sensitivity analysis and probabilistic sensitivity analysis were performed to test model robustness. The results suggest that if FLOSEAL is utilized in a hospital that performs 245 mixed cardiac surgery procedures annually, 11 major complications, 31 minor complications, nine surgical revisions, 79 blood product transfusions, and 260.3 h of cumulative operating time could be avoided. These improved outcomes correspond to a net annualized saving of $1,532,896. Cost savings remained consistent between $1.3m and $1.8m and between $911k and $2.4m, even after accounting for the uncertainty around clinical and cost inputs, in a one-way and probabilistic sensitivity analysis, respectively. Outcome differences associated with FLOSEAL vs SURGIFLO

RASCAL 4.l: evaluation system for the analysis of the radiological consequences

International Nuclear Information System (INIS)

Miguel, I. de; Gomez-Arguello, B.

2012-01-01

Recently the Spanish Nuclear Safety Council (CSN) has promoted the replacement of the code used in the Spanish Nuclear Power Plants to estimate potential and actual doses due to atmospheric releases. IRDAM Code (interactive Rapid Dose Assessment Model, 1983) by RASCAL Code version 4.1 (Radiological Assessment System for consequence Analysis). This code was developed by the NRC (Nuclear Regulatory Commission) to evaluate releases from nuclear power plants, spent fuel storage pools and casks, fuel cycle facilities and radioactive material handling facilities. RASCAL was officially requested to the Spanish nuclear power plants in February 1st, 2012, and it can be used for external dose assessment and to evaluate the recommended protective action for the public in a specific situation (sheltering, prophylaxis, evacuation, etc.). (Author)

Aspects of risk analysis application to estimation of nuclear accidents and tests consequences and intervention management

International Nuclear Information System (INIS)

Demin, V.F.; Hedemann-Jensen, P.; Rolevich, I.V.; Schneider, T.S.; Sobolev, B.G.

1996-01-01

For assessment of accident consequences and a post-accident management a risk analysis methodology and data bank (BARD) with allowance for radiation and non-radiation risk causes should be developed and used. Aspects of these needs and developments are considered. Some illustrative results of health risk estimation made with BARD for the Bryansk region territory with relatively high radioactive contamination from the Chernobyl accident are presented

A nutrient-driven tRNA modification alters translational fidelity and genome-wide protein coding across an animal genus.

Science.gov (United States)

Zaborske, John M; DuMont, Vanessa L Bauer; Wallace, Edward W J; Pan, Tao; Aquadro, Charles F; Drummond, D Allan

2014-12-01

Natural selection favors efficient expression of encoded proteins, but the causes, mechanisms, and fitness consequences of evolved coding changes remain an area of aggressive inquiry. We report a large-scale reversal in the relative translational accuracy of codons across 12 fly species in the Drosophila/Sophophora genus. Because the reversal involves pairs of codons that are read by the same genomically encoded tRNAs, we hypothesize, and show by direct measurement, that a tRNA anticodon modification from guanosine to queuosine has coevolved with these genomic changes. Queuosine modification is present in most organisms but its function remains unclear. Modification levels vary across developmental stages in D. melanogaster, and, consistent with a causal effect, genes maximally expressed at each stage display selection for codons that are most accurate given stage-specific queuosine modification levels. In a kinetic model, the known increased affinity of queuosine-modified tRNA for ribosomes increases the accuracy of cognate codons while reducing the accuracy of near-cognate codons. Levels of queuosine modification in D. melanogaster reflect bioavailability of the precursor queuine, which eukaryotes scavenge from the tRNAs of bacteria and absorb in the gut. These results reveal a strikingly direct mechanism by which recoding of entire genomes results from changes in utilization of a nutrient.

A nutrient-driven tRNA modification alters translational fidelity and genome-wide protein coding across an animal genus.

Directory of Open Access Journals (Sweden)

John M Zaborske

2014-12-01

Full Text Available Natural selection favors efficient expression of encoded proteins, but the causes, mechanisms, and fitness consequences of evolved coding changes remain an area of aggressive inquiry. We report a large-scale reversal in the relative translational accuracy of codons across 12 fly species in the Drosophila/Sophophora genus. Because the reversal involves pairs of codons that are read by the same genomically encoded tRNAs, we hypothesize, and show by direct measurement, that a tRNA anticodon modification from guanosine to queuosine has coevolved with these genomic changes. Queuosine modification is present in most organisms but its function remains unclear. Modification levels vary across developmental stages in D. melanogaster, and, consistent with a causal effect, genes maximally expressed at each stage display selection for codons that are most accurate given stage-specific queuosine modification levels. In a kinetic model, the known increased affinity of queuosine-modified tRNA for ribosomes increases the accuracy of cognate codons while reducing the accuracy of near-cognate codons. Levels of queuosine modification in D. melanogaster reflect bioavailability of the precursor queuine, which eukaryotes scavenge from the tRNAs of bacteria and absorb in the gut. These results reveal a strikingly direct mechanism by which recoding of entire genomes results from changes in utilization of a nutrient.

Changes in Classes of Injury-Related Risks and Consequences of Risk-Level Drinking: a Latent Transition Analysis.

Science.gov (United States)

Cochran, Gerald; Field, Craig; Caetano, Raul

2015-07-01

Risk-level drinking, drinking and driving, and alcohol-related violence are risk factors that result in injuries. The current study sought to identify which subgroups of patients experience the most behavioral change following a brief intervention. A secondary analysis of data from a brief alcohol intervention study was conducted. The sample (N = 664) includes at-risk drinkers who experienced an injury and were admitted for care to a Level 1 trauma center. Injury-related items from the Short Inventory of Problems+6 were used to perform a latent transition analysis to describe class transitions participants experienced following discharge. Four classes emerged for the year before and after the current injury. Most individuals transitioned from higher-risk classes into those with lower risk. Some participants maintained risky profiles, and others increased risks and consequences. Drinking and driving remained a persistent problem among the study participants. Although a large portion of intervention recipients improved risks and consequences of alcohol use following discharge, more intensive intervention services may be needed for a subset of patients who showed little or no improvement.

Comparative proteome analysis between C . briggsae embryos and larvae reveals a role of chromatin modification proteins in embryonic cell division

KAUST Repository

An, Xiaomeng

2017-06-21

Caenorhabditis briggsae has emerged as a model for comparative biology against model organism C. elegans. Most of its cell fate specifications are completed during embryogenesis whereas its cell growth is achieved mainly in larval stages. The molecular mechanism underlying the drastic developmental changes is poorly understood. To gain insights into the molecular changes between the two stages, we compared the proteomes between the two stages using iTRAQ. We identified a total of 2,791 proteins in the C. briggsae embryos and larvae, 247 of which undergo up- or down-regulation between the two stages. The proteins that are upregulated in the larval stages are enriched in the Gene Ontology categories of energy production, protein translation, and cytoskeleton; whereas those upregulated in the embryonic stage are enriched in the categories of chromatin dynamics and posttranslational modification, suggesting a more active chromatin modification in the embryos than in the larva. Perturbation of a subset of chromatin modifiers followed by cell lineage analysis suggests their roles in controlling cell division pace. Taken together, we demonstrate a general molecular switch from chromatin modification to metabolism during the transition from C. briggsae embryonic to its larval stages using iTRAQ approach. The switch might be conserved across metazoans.

Complete abandonment of nuclear power and aggregate consequences

International Nuclear Information System (INIS)

Heilemann, U.; Weiss, T.

1986-01-01

The aggregate social and economic consequences of a complete abandonment of nuclear power very often are pushed to the background in discussions about the MCA. But backing out of nuclear energy will not be achieved or left without costs. The authors present an analysis of the short-term aggregate consequences. (orig./UA) [de

Biomaterials modification by ion beam

International Nuclear Information System (INIS)

Zhang Tonghe; Yi Zhongzhen; Zhang Xu; Wu Yuguang

2001-01-01

Ion beam technology is one of best ways for the modification of biomaterials. The results of ion beam modification of biomaterials are given. The method and results of improved biocompatibility are indicated by ion beam technology. The future development of ion beam modification of biomaterials is discussed

Different drinking motives, different adverse consequences?

DEFF Research Database (Denmark)

Wicki, Matthias; Kuntsche, Emmanuel; Eichenberger, Yvonne

2017-01-01

INTRODUCTION AND AIM: This study, which builds on previous research demonstrating that drinking motives are associated with adverse consequences, investigates the associations between drinking motives and non-alcohol-attributed adverse consequences and disentangles alcohol-related and direct......, differences across countries were tested in a multigroup analysis. RESULTS: The indirect effect (via alcohol use) was greater for injuries and academic problems than for more general outcomes such as life dissatisfaction and negative body image. For social, enhancement and coping motives, we found positive...... indirect effects (via alcohol use) on injuries and academic problems; the association was negative for conformity motives. The direct effect, that is, the effect above and beyond alcohol use, indicated more negative consequences among those who tended to drink more frequently for coping motives. More...

Three consequences of the 2012 general elections

Directory of Open Access Journals (Sweden)

Daniel Buti

2013-04-01

Full Text Available The article represents an analysis of the 2012 general elections and their consequences on the Romanian political system. The variables analysed in the study are: the effective number of parties (N, the level of electoral disproportionality (G and the nature of bicameralism. Although measured indicators appear to call for an institutional approach and a formal analysis, the article tries to capture and simultaneously takes into account the functional dimension of the political system too. Thus, the consequences of the 2012 parliamentary elections reveal not necessarily the imbalance in the party system or the improvisation of a delegitimized electoral formula, but rather the current makeshift relationships between actors.

Surface modification effects on defect-related photoluminescence in colloidal CdS quantum dots.

Science.gov (United States)

Lee, TaeGi; Shimura, Kunio; Kim, DaeGwi

2018-05-03

We investigated the effects of surface modification on the defect-related photoluminescence (PL) band in colloidal CdS quantum dots (QDs). A size-selective photoetching process and a surface modification technique with a Cd(OH)2 layer enabled the preparation of size-controlled CdS QDs with high PL efficiency. The Stokes shift of the defect-related PL band before and after the surface modification was ∼1.0 eV and ∼0.63 eV, respectively. This difference in the Stokes shifts suggests that the origin of the defect-related PL band was changed by the surface modification. Analysis by X-ray photoelectron spectroscopy revealed that the surface of the CdS QDs before and after the surface modification was S rich and Cd rich, respectively. These results suggest that Cd-vacancy acceptors and S-vacancy donors affect PL processes in CdS QDs before and after the surface modification, respectively.

Modification of JRR-2

International Nuclear Information System (INIS)

Miyasaka, Yasuhiko

1978-01-01

This report gives an outline of some of the main modifications carried out around the Reactor Core on the Research Reactor JRR-2, at the Tokai Research Establishment of JAERI. The JRR-2 was shut down in December 1973, to improve it in heavy water leakage from the metal packing between core tank and support ring, corrosion of the lower shielding plug, and fault in the control-rod mechanism. Main modifications were a standing seal weld at the support ring to stop heavy water leakage, replacement of the reactor top shield and improvement of the helium system. The control-rod assemblies and the refueling devices were replaced by the newly designed ones also. In addition to the modification plan, the irradiated air exhaust system was improved to reduce radioactive argon gas release through the stack. Works were completed successfully in September 1975. But a light water leakage occurred at the stand pipe below the light water tank on November 11, 1975, which was repaired in about 4 months. When considering the operation of above 5,000 hours after the modification, however, the quality of the modification work may be said to be quite satisfactory. The present report in which works to the completion are described may be valuable as a record of reactor modification which is a new experience at JAERI. (auth.)

Enhancing the water stability of Al-MIL-101-NH2 via postsynthetic modification.

Science.gov (United States)

Wittmann, Thomas; Siegel, Renée; Reimer, Nele; Milius, Wolfgang; Stock, Norbert; Senker, Jürgen

2015-01-02

The resistance of metal-organic frameworks towards water is a very critical issue concerning their practical use. Recently, it was shown for microporous MOFs that the water stability could be increased by introducing hydrophobic pendant groups. Here, we demonstrate a remarkable stabilisation of the mesoporous MOF Al-MIL-101-NH2 by postsynthetic modification with phenyl isocyanate. In this process 86 % of the amino groups were converted into phenylurea units. As a consequence, the long-term stability of Al-MIL-101-URPh in liquid water could be extended beyond a week. In water saturated atmospheres Al-MIL-101-URPh decomposed at least 12-times slower than the unfunctionalised analogue. To study the underlying processes both materials were characterised by Ar, N2 and H2 O sorption measurements, powder X-ray diffraction, thermogravimetric and chemical analysis as well as solid-state NMR and IR spectroscopy. Postsynthetic modification decreased the BET equivalent surface area from 3363 to 1555 m(2)  g(-1) for Al-MIL-101-URPh and reduced the mean diameters of the mesopores by 0.6 nm without degrading the structure significantly and reducing thermal stability. In spite of similar water uptake capacities, the relative humidity-dependent uptake of Al-MIL-101-URPh is slowed and occurs at higher relative humidity values. In combination with (1) H-(27) Al D-HMQC NMR spectroscopy experiments this favours a shielding mechanism of the Al clusters by the pendant phenyl groups and rules out pore blocking. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Modifications of the bubble rise model and heat transfer model used in RELAP 4/Mod 5 computer code for transient analysis

International Nuclear Information System (INIS)

Scharfmann, E.; Silva, D.E. da

1981-01-01

The modifications on the phase separation model and heat tranfer model in Relap4/Mod 5 computer code, in order to make more realistic estimates of the core thermohydraulic behavior submitted to a loss of coolant accident. This research is directed to the accident analysis caused by small breaks in the primary circuits of PWR plants, where two-phase flow occurs most of the time. Calculation have been performed with the help of the original version of Relap code, as well as the version containing the proposed modifications on this work. Comparing one results with the original ones, we arrive at the conclusion that our results show more conservative values of core pressure and coolant temperature, while the peak values of fuel temperature are not exceeded. (Author) [pt

RASCAL [Radiological Assessment System for Consequence AnaLysis]: A screening model for estimating doses from radiological accidents

International Nuclear Information System (INIS)

Sjoreen, A.L.; Athey, G.F.; Sakenas, C.A.; McKenna, T.J.

1988-01-01

The Radiological Assessment System for Consequence AnaLysis (RASCAL) is a new MS-DOS-based dose assessment model which has been written for the US Nuclear Regulatory Commission for use during response to radiological emergencies. RASCAL is designed to provide crude estimates of the effects of an accident while the accident is in progress and only limited information is available. It has been designed to be very simple to use and to run quickly. RASCAL is unique in that it estimates the source term based on fundamental plant conditions and does not rely solely on release rate estimation (e.g., Ci/sec of I-131). Therefore, it can estimate consequences of accidents involving unmonitored pathways or projected failures. RASCAL will replace the older model, IRDAM. 6 refs

Cradle modification for hydraulic ram

International Nuclear Information System (INIS)

Koons, B.M.

1995-01-01

The analysis of the cradle hydraulic system considers stress, weld strength, and hydraulic forces required to lift and support the cradle/pump assembly. The stress and weld strength of the cradle modifications is evaluated to ensure that they meet the requirements of the American Institute for Steel Construction (AISC 1989). The hydraulic forces are evaluated to ensure that the hydraulic system is capable of rotating the cradle and pump assembly to the vertical position (between 70 degrees and 90 degrees)

Post-Translational Modifications of Desulfovibrio vulgaris Hildenborough Sulfate Reduction Pathway Proteins

Energy Technology Data Exchange (ETDEWEB)

Gaucher, S.P.; Redding, A.M.; Mukhopadhyay, A.; Keasling, J.D.; Singh, A.K.

2008-03-01

Recent developments in shotgun proteomics have enabled high-throughput studies of a variety of microorganisms at a proteome level and provide experimental validation for predicted open reading frames in the corresponding genome. More importantly, advances in mass spectrometric data analysis now allow mining of large proteomics data sets for the presence of post-translational modifications(PTMs). Although PTMs are a critical aspectof cellular activity, such information eludes cell-wide studies conducted at the transcript level. Here, we analyze several mass spectrometric data sets acquired using two-dimensional liquid chromatography tandem mass spectrometry, 2D-LC/MS/MS, for the sulfate reducing bacterium, Desulfovibrio vulgaris Hildenborough. Our searches of the raw spectra led us to discover several post-translationally modified peptides in D. vulgaris. Of these, several peptides containing a lysine with a +42 Da modification were found reproducibly across all data sets. Both acetylation and trimethylation have the same nominal +42 Da mass, and are therefore candidates for this modification. Several spectra were identified having markers for trimethylation, while one is consistent with an acetylation. Surprisingly, these modified peptides predominantly mapped to proteins involved in sulfate respiration. Other highly expressed proteins in D. vulgaris, such as enzymes involved in electron transport and other central metabolic processes, did not contain this modification. Decoy database searches were used to control for random spectrum/sequence matches. Additional validation for these modifications was provided by alternate workflows, for example, two-dimensional gel electrophoresis followed by mass spectrometry analysis of the dissimilatory sulfite reductase gamma-subunit(DsrC) protein. MS data for DsrC in this alternate workflow also contained the +42 Da modification at the same loci. Furthermore, the DsrC homologue in another sulfate reducing bacterium

Consequence analysis and probabilistic safety analysis of Angra-1

International Nuclear Information System (INIS)

Guimaraes, A.C.F.

1987-07-01

A methodology for determining the environmental consequences in the site of nuclear power plants, is presented. The methodology obtains as final result the 'S' site matrix, which represents the probabilities of health damage. Two types of healt damages were analysed: the early fatalities and injury. The damages are calculated from the determination of radiation doses which the population in surrounding of the site could be submitted, in the case of severe accident with the core meltdown. The accidents are defined from an initial event, leading to the failure of reactor containment. The results presented the same magnitude order when they were compared with ones obtained in studies of the Zion Nuclear Power Plant. The Angra-1 was adopted as reference reactor and the CRAC-2 computer code was used. (M.C.K.) [pt

Permit application modifications

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-11-01

This document contains the Permit Application Modifications for the Y-12 Industrial Landfill V site on the Oak Ridge Reservation. These modifications include the assessment of stability of the proposed Landfill V under static and loading conditions. Analyses performed include the general slope stability, veneer stability of the bottom liner and cover system, and a liquefaction potential assessment of the foundation soils.

Permit application modifications

International Nuclear Information System (INIS)

1995-11-01

This document contains the Permit Application Modifications for the Y-12 Industrial Landfill V site on the Oak Ridge Reservation. These modifications include the assessment of stability of the proposed Landfill V under static and loading conditions. Analyses performed include the general slope stability, veneer stability of the bottom liner and cover system, and a liquefaction potential assessment of the foundation soils

Radiological consequence analysis. Report on the work package 10. Preliminary safety analysis for the site Gorleben; Radiologische Konsequenzanalyse. Bericht zum Arbeitspaket 10. Vorlaeufige Sicherheitsanalyse fuer den Standort Gorleben

Energy Technology Data Exchange (ETDEWEB)

Larue, Juergen; Baltes, Bruno; Fischer, Heidemarie; Frieling, Gerd; Kock, Ingo; Navarro, Martin; Seher, Holger

2013-02-15

Work package 10 of the preliminary safety analysis for the site Gorleben concerns the analysis of release scenarios and the radiological consequences. The report includes the description of the applied methodology, the concept for the mathematical description of scenarios, the variety of scenarios for the radiological consequence analysis with the definition of the reference scenario. The database for the calculation covers geology and hydrology, the final repository concept and the process of the final disposal system. The used models were the one-phase transport model MARINE and the two-phase transport model TOUGH2. The report summarizes the results including an evaluation of the realization of the demonstration concept with respect to solution transport, fluid transport, robustness of the modeling results and analogy discussion to other disposal variants (i.e. borehole disposal and storage of transport or storage casks).

The reality of life safety consequence classification

International Nuclear Information System (INIS)

Hartford, D.N.D.; Assaf, H.; Kerr, I.R.

1999-01-01

Because empirical methods of consequence estimation were not designed for application in risk analysis for dam safety, BC Hydro developed its own method for determining loss of life due to dam failures as part of the development of the risk analysis process. Because loss of life estimation for consequence classification entails the generation of essentially the same information, the method can also be used to determine the consequence category of the dam for life safety considerations, and the model can be extended to third party property damage. The methodology adopted for dealing with life safety differs considerably from the empirical approach by modelling the response of the downstream population to a dam failure flood. The algorithm simulates the response of various groups of populations to the warnings of dam failure and the physical process of fleeing from the areas of potential innundation. Assessing the life safety consequences of dam failure is a first step in estimating dam safety in terms of CDA Guidelines, and empirical methods in use are not suitable for determining loss of life due to dam failures. The process described herein is the only physically based method available for estimating loss of life due to dam failures required by the Dam Safety Guidelines. The model is transparent, logically sound, and has been peer reviewed. The method provides a rational basis for the first step in performing safety assessments of dams in terms of the Guidelines, particularly high consequence dams. 8 refs., 3 figs

Age-related carbonylation of fibrocartilage structural proteins drives tissue degenerative modification.

Science.gov (United States)

Scharf, Brian; Clement, Cristina C; Yodmuang, Supansa; Urbanska, Aleksandra M; Suadicani, Sylvia O; Aphkhazava, David; Thi, Mia M; Perino, Giorgio; Hardin, John A; Cobelli, Neil; Vunjak-Novakovic, Gordana; Santambrogio, Laura

2013-07-25

Aging-related oxidative stress has been linked to degenerative modifications in different organs and tissues. Using redox proteomic analysis and illustrative tandem mass spectrometry mapping, we demonstrate oxidative posttranslational modifications in structural proteins of intervertebral discs (IVDs) isolated from aging mice. Increased protein carbonylation was associated with protein fragmentation and aggregation. Complementing these findings, a significant loss of elasticity and increased stiffness was measured in fibrocartilage from aging mice. Studies using circular dichroism and intrinsic tryptophan fluorescence revealed a significant loss of secondary and tertiary structures of purified collagens following oxidation. Collagen unfolding and oxidation promoted both nonenzymatic and enzymatic degradation. Importantly, induction of oxidative modification in healthy fibrocartilage recapitulated the biochemical and biophysical modifications observed in the aging IVD. Together, these results suggest that protein carbonylation, glycation, and lipoxidation could be early events in promoting IVD degenerative changes. Copyright © 2013 Elsevier Ltd. All rights reserved.

Comparative genome and methylome analysis reveals restriction/modification system diversity in the gut commensal Bifidobacterium breve

Science.gov (United States)

Bottacini, Francesca; Morrissey, Ruth; Roberts, Richard John; James, Kieran; van Breen, Justin; Egan, Muireann; Lambert, Jolanda; van Limpt, Kees; Knol, Jan; Motherway, Mary O’Connell; van Sinderen, Douwe

2018-01-01

Abstract Bifidobacterium breve represents one of the most abundant bifidobacterial species in the gastro-intestinal tract of breast-fed infants, where their presence is believed to exert beneficial effects. In the present study whole genome sequencing, employing the PacBio Single Molecule, Real-Time (SMRT) sequencing platform, combined with comparative genome analysis allowed the most extensive genetic investigation of this taxon. Our findings demonstrate that genes encoding Restriction/Modification (R/M) systems constitute a substantial part of the B. breve variable gene content (or variome). Using the methylome data generated by SMRT sequencing, combined with targeted Illumina bisulfite sequencing (BS-seq) and comparative genome analysis, we were able to detect methylation recognition motifs and assign these to identified B. breve R/M systems, where in several cases such assignments were confirmed by restriction analysis. Furthermore, we show that R/M systems typically impose a very significant barrier to genetic accessibility of B. breve strains, and that cloning of a methyltransferase-encoding gene may overcome such a barrier, thus allowing future functional investigations of members of this species. PMID:29294107

Fast Multi-blind Modification Search through Tandem Mass Spectrometry*

Science.gov (United States)

Na, Seungjin; Bandeira, Nuno; Paek, Eunok

2012-01-01

With great biological interest in post-translational modifications (PTMs), various approaches have been introduced to identify PTMs using MS/MS. Recent developments for PTM identification have focused on an unrestrictive approach that searches MS/MS spectra for all known and possibly even unknown types of PTMs at once. However, the resulting expanded search space requires much longer search time and also increases the number of false positives (incorrect identifications) and false negatives (missed true identifications), thus creating a bottleneck in high throughput analysis. Here we introduce MODa, a novel “multi-blind” spectral alignment algorithm that allows for fast unrestrictive PTM searches with no limitation on the number of modifications per peptide while featuring over an order of magnitude speedup in relation to existing approaches. We demonstrate the sensitivity of MODa on human shotgun proteomics data where it reveals multiple mutations, a wide range of modifications (including glycosylation), and evidence for several putative novel modifications. Based on the reported findings, we argue that the efficiency and sensitivity of MODa make it the first unrestrictive search tool with the potential to fully replace conventional restrictive identification of proteomics mass spectrometry data. PMID:22186716

Behavior Modification in Coaching.

Science.gov (United States)

Lynch, Annette Rutt; Stillman, Stephen M.

1979-01-01

An example of behavior modification used in athletic coaching is presented. The case study involves a member of a women's basketball team and details the use of behavior modification for both weight reduction and skill improvement. (JMF)

Maillard reaction versus other nonenzymatic modifications in neurodegenerative processes.

Science.gov (United States)

Pamplona, Reinald; Ilieva, Ekaterina; Ayala, Victoria; Bellmunt, Maria Josep; Cacabelos, Daniel; Dalfo, Esther; Ferrer, Isidre; Portero-Otin, Manuel

2008-04-01

Nonenzymatic protein modifications are generated from direct oxidation of amino acid side chains and from reaction of the nucleophilic side chains of specific amino acids with reactive carbonyl species. These reactions give rise to specific markers that have been analyzed in different neurodegenerative diseases sharing protein aggregation, such as Alzheimer's disease, Pick's disease, Parkinson's disease, dementia with Lewy bodies, Creutzfeldt-Jakob disease, and amyotrophic lateral sclerosis. Collectively, available data demonstrate that oxidative stress homeostasis, mitochondrial function, and energy metabolism are key factors in determining the disease-specific pattern of protein molecular damage. In addition, these findings suggest the lack of a "gold marker of oxidative stress," and, consequently, they strengthen the need for a molecular dissection of the nonenzymatic reactions underlying neurodegenerative processes.

Effects of Computer-Based Training on Procedural Modifications to Standard Functional Analyses

Science.gov (United States)

Schnell, Lauren K.; Sidener, Tina M.; DeBar, Ruth M.; Vladescu, Jason C.; Kahng, SungWoo

2018-01-01

Few studies have evaluated methods for training decision-making when functional analysis data are undifferentiated. The current study evaluated computer-based training to teach 20 graduate students to arrange functional analysis conditions, analyze functional analysis data, and implement procedural modifications. Participants were exposed to…

MELCOR aerosol transport module modification for NSSR-1

International Nuclear Information System (INIS)

Merrill, B.J.; Hagrman, D.L.

1996-03-01

This report describes modifications of the MELCOR computer code aerosol transport module that will increase the accuracy of calculations for safety analysis of the International Thermonuclear Experimental Reactor (ITER). The modifications generalize aerosol deposition models to consider gases other than air, add specialized models for aerosol deposition during high speed gas flows in ducts, and add models for resuspension of aerosols that are entrained in coolants when these coolants flash. Particular attention has been paid to the adhesion of aerosol particles once they are transported to duct walls. The results of calculations with the modified models have been successfully compared to data from Light Water Reactor Aerosol Containment Experiments (LACE) conducted by an international consortium at Hanford, Washington

Cross-Talk between Dnmt2-Dependent tRNA Methylation and Queuosine Modification

Directory of Open Access Journals (Sweden)

Ann E. Ehrenhofer-Murray

2017-02-01

Full Text Available Enzymes of the Dnmt2 family of methyltransferases have yielded a number of unexpected discoveries. The first surprise came more than ten years ago when it was realized that, rather than being DNA methyltransferases, Dnmt2 enzymes actually are transfer RNA (tRNA methyltransferases for cytosine-5 methylation, foremost C38 (m5C38 of tRNAAsp. The second unanticipated finding was our recent discovery of a nutritional regulation of Dnmt2 in the fission yeast Schizosaccharomyces pombe. Significantly, the presence of the nucleotide queuosine in tRNAAsp strongly stimulates Dnmt2 activity both in vivo and in vitro in S. pombe. Queuine, the respective base, is a hypermodified guanine analog that is synthesized from guanosine-5’-triphosphate (GTP by bacteria. Interestingly, most eukaryotes have queuosine in their tRNA. However, they cannot synthesize it themselves, but rather salvage it from food or from gut microbes. The queuine obtained from these sources comes from the breakdown of tRNAs, where the queuine ultimately was synthesized by bacteria. Queuine thus has been termed a micronutrient. This review summarizes the current knowledge of Dnmt2 methylation and queuosine modification with respect to translation as well as the organismal consequences of the absence of these modifications. Models for the functional cooperation between these modifications and its wider implications are discussed.

IEA-R1 renewed primary coolant piping system stress analysis

International Nuclear Information System (INIS)

Fainer, Gerson; Faloppa, Altair A.; Oliveira, Carlos A. de; Mattar Neto, Miguel

2015-01-01

A partial replacement of the IEA-R1 piping system was conducted in 2014. The aim of this work is to perform the stress analysis of the renewed primary piping system of the IEA-R1, taking into account the as built conditions and the pipe modifications. The nuclear research reactor IEA-R1 is a pool type reactor designed by Babcox-Willcox, which is operated by IPEN since 1957. The primary coolant system is responsible for removing the residual heat of the Reactor core. As a part of the life management, a regular inspection detected some degradation in the primary piping system. In consequence, part of the piping system was replaced. The partial renewing of the primary piping system did not imply in major piping layout modifications. However, the stress condition of the piping systems had to be reanalyzed. The structural stress analysis of the primary piping systems is now presented and the final results are discussed. (author)

Uncertainty and sensitivity analysis of chronic exposure results with the MACCS reactor accident consequence model

International Nuclear Information System (INIS)

Helton, J.C.; Johnson, J.D.; Rollstin, J.A.; Shiver, A.W.; Sprung, J.L.

1995-01-01

Uncertainty and sensitivity analysis techniques based on Latin hypercube sampling, partial correlation analysis and stepwise regression analysis are used in an investigation with the MACCS model of the chronic exposure pathways associated with a severe accident at a nuclear power station. The primary purpose of this study is to provide guidance on the variables to be considered in future review work to reduce the uncertainty in the important variables used in the calculation of reactor accident consequences. The effects of 75 imprecisely known input variables on the following reactor accident consequences are studied: crop growing season dose, crop long-term dose, water ingestion dose, milk growing season dose, long-term groundshine dose, long-term inhalation dose, total food pathways dose, total ingestion pathways dose, total long-term pathways dose, total latent cancer fatalities, area-dependent cost, crop disposal cost, milk disposal cost, population-dependent cost, total economic cost, condemnation area, condemnation population, crop disposal area and milk disposal area. When the predicted variables are considered collectively, the following input variables were found to be the dominant contributors to uncertainty: dry deposition velocity, transfer of cesium from animal feed to milk, transfer of cesium from animal feed to meat, ground concentration of Cs-134 at which the disposal of milk products will be initiated, transfer of Sr-90 from soil to legumes, maximum allowable ground concentration of Sr-90 for production of crops, fraction of cesium entering surface water that is consumed in drinking water, groundshine shielding factor, scale factor defining resuspension, dose reduction associated with decontamination, and ground concentration of 1-131 at which disposal of crops will be initiated due to accidents that occur during the growing season

Evidence of Coal-Fly-Ash Toxic Chemical Geoengineering in the Troposphere: Consequences for Public Health

Directory of Open Access Journals (Sweden)

J. Marvin Herndon

2015-08-01

Full Text Available The widespread, intentional and increasingly frequent chemical emplacement in the troposphere has gone unidentified and unremarked in the scientific literature for years. The author presents evidence that toxic coal combustion fly ash is the most likely aerosolized particulate sprayed by tanker-jets for geoengineering, weather-modification and climate-modification purposes and describes some of the multifold consequences on public health. Two methods are employed: (1 Comparison of 8 elements analyzed in rainwater, leached from aerosolized particulates, with corresponding elements leached into water from coal fly ash in published laboratory experiments, and (2 Comparison of 14 elements analyzed in dust collected outdoors on a high-efficiency particulate air (HEPA filter with corresponding elements analyzed in un-leached coal fly ash material. The results show: (1 the assemblage of elements in rainwater and in the corresponding experimental leachate are essentially identical. At a 99% confidence interval, they have identical means (T-test and identical variances (F-test; and (2 the assemblage of elements in the HEPA dust and in the corresponding average un-leached coal fly ash are likewise essentially identical. The consequences on public health are profound, including exposure to a variety of toxic heavy metals, radioactive elements, and neurologically-implicated chemically mobile aluminum released by body moisture in situ after inhalation or through transdermal induction.

Implementing shared decision-making: consider all the consequences.

Science.gov (United States)

Elwyn, Glyn; Frosch, Dominick L; Kobrin, Sarah

2016-08-08

challenges. In the long-term, shared decision-making might lead to changes in resource utilization, perhaps to reductions in cost, and to modification of workforce composition. Despite the gradual shift to value-based payment, some organizations, motivated by continued income derived from achieving high volumes of procedures and contacts, will see this as a negative consequence. We suggest that a broader conceptualization and measurement of shared decision-making would provide a more substantive evidence base to guide implementation. We outline a framework which illustrates a hypothesized set of proximal, distal, and distant consequences that might occur if collaboration and deliberation could be achieved routinely, proposing that well-informed preference-based patient decisions might lead to safer, more cost-effective healthcare, which in turn might result in reduced utilization rates and improved health outcomes.

Life cycle-dependent cytoskeletal modifications in Plasmodium falciparum infected erythrocytes.

Directory of Open Access Journals (Sweden)

Hui Shi

Full Text Available Plasmodium falciparum infection of human erythrocytes is known to result in the modification of the host cell cytoskeleton by parasite-coded proteins. However, such modifications and corresponding implications in malaria pathogenesis have not been fully explored. Here, we probed the gradual modification of infected erythrocyte cytoskeleton with advancing stages of infection using atomic force microscopy (AFM. We reported a novel strategy to derive accurate and quantitative information on the knob structures and their connections with the spectrin network by performing AFM-based imaging analysis of the cytoplasmic surface of infected erythrocytes. Significant changes on the red cell cytoskeleton were observed from the expansion of spectrin network mesh size, extension of spectrin tetramers and the decrease of spectrin abundance with advancing stages of infection. The spectrin network appeared to aggregate around knobs but also appeared sparser at non-knob areas as the parasite matured. This dramatic modification of the erythrocyte skeleton during the advancing stage of malaria infection could contribute to the loss of deformability of the infected erythrocyte.

Life cycle-dependent cytoskeletal modifications in Plasmodium falciparum infected erythrocytes.

Science.gov (United States)

Shi, Hui; Liu, Zhuo; Li, Ang; Yin, Jing; Chong, Alvin G L; Tan, Kevin S W; Zhang, Yong; Lim, Chwee Teck

2013-01-01

Plasmodium falciparum infection of human erythrocytes is known to result in the modification of the host cell cytoskeleton by parasite-coded proteins. However, such modifications and corresponding implications in malaria pathogenesis have not been fully explored. Here, we probed the gradual modification of infected erythrocyte cytoskeleton with advancing stages of infection using atomic force microscopy (AFM). We reported a novel strategy to derive accurate and quantitative information on the knob structures and their connections with the spectrin network by performing AFM-based imaging analysis of the cytoplasmic surface of infected erythrocytes. Significant changes on the red cell cytoskeleton were observed from the expansion of spectrin network mesh size, extension of spectrin tetramers and the decrease of spectrin abundance with advancing stages of infection. The spectrin network appeared to aggregate around knobs but also appeared sparser at non-knob areas as the parasite matured. This dramatic modification of the erythrocyte skeleton during the advancing stage of malaria infection could contribute to the loss of deformability of the infected erythrocyte.

Genome-wide identification of sweet orange (Citrus sinensis) histone modification gene families and their expression analysis during the fruit development and fruit-blue mold infection process.

Science.gov (United States)

Xu, Jidi; Xu, Haidan; Liu, Yuanlong; Wang, Xia; Xu, Qiang; Deng, Xiuxin

2015-01-01

In eukaryotes, histone acetylation and methylation have been known to be involved in regulating diverse developmental processes and plant defense. These histone modification events are controlled by a series of histone modification gene families. To date, there is no study regarding genome-wide characterization of histone modification related genes in citrus species. Based on the two recent sequenced sweet orange genome databases, a total of 136 CsHMs (Citrus sinensis histone modification genes), including 47 CsHMTs (histone methyltransferase genes), 23 CsHDMs (histone demethylase genes), 50 CsHATs (histone acetyltransferase genes), and 16 CsHDACs (histone deacetylase genes) were identified. These genes were categorized to 11 gene families. A comprehensive analysis of these 11 gene families was performed with chromosome locations, phylogenetic comparison, gene structures, and conserved domain compositions of proteins. In order to gain an insight into the potential roles of these genes in citrus fruit development, 42 CsHMs with high mRNA abundance in fruit tissues were selected to further analyze their expression profiles at six stages of fruit development. Interestingly, a numbers of genes were expressed highly in flesh of ripening fruit and some of them showed the increasing expression levels along with the fruit development. Furthermore, we analyzed the expression patterns of all 136 CsHMs response to the infection of blue mold (Penicillium digitatum), which is the most devastating pathogen in citrus post-harvest process. The results indicated that 20 of them showed the strong alterations of their expression levels during the fruit-pathogen infection. In conclusion, this study presents a comprehensive analysis of the histone modification gene families in sweet orange and further elucidates their behaviors during the fruit development and the blue mold infection responses.

Modification of the mesoscopic structure in neutron irradiated EPDM viewed through positron annihilation spectroscopy and dynamic mechanical analysis

International Nuclear Information System (INIS)

Lambri, O.A.; Plazaola, F.; Axpe, E.; Mocellini, R.R.; Zelada-Lambri, G.I.; Garcia, J.A.; Matteo, C.L.; Sorichetti, P.A.

2011-01-01

This article focuses on the study of the mesoscopic structure in neutron irradiated EPDM both from experimental and theoretical points of view. In this work we reveal completely the modification of the mesostructure of the EPDM due to neutron irradiation, resolving volume fraction, size and distribution of the crystalline zones as a function of the irradiation dose. Positron annihilation spectroscopy and dynamic mechanical analysis techniques are applied and the results are discussed by means of new theoretical results for describing the interaction process between the crystals and amorphous zones in EPDM.

Risk-based consequences of extreme natural hazard processes in mountain regions - Multi-hazard analysis in Tyrol (Austria)

Science.gov (United States)

Huttenlau, Matthias; Stötter, Johann

2010-05-01

weighting within the risk concept, this has sufficient implications on the results of risk analyses. Thus, an equal and scale appropriated balance of those risk components is a fundamental key factor for effective natural hazard risk analyses. The results of such analyses inform especially decision makers in the insurance industry, the administration, and politicians on potential consequences and are the basis for appropriate risk management strategies. Thereby, results (i) on an annual or probabilistic risk comprehension have to be distinguished from (ii) scenario-based analyses. The first analyses are based on statistics of periodically or episodically occurring events whereas the latter approach is especially applied for extreme, non-linear, stochastic events. Focusing on the needs especially of insurance companies, the first approaches are appropriate for premium pricing and reinsurance strategies with an annual perspective, whereas the latter is focusing on events with extreme loss burdens under worst-case criteria to guarantee accordant reinsurance coverage. Moreover, the demand of adequate loss model approaches and methods is strengthened by the risk-based requirements of the upcoming capital requirement directive Solvency II. The present study estimates the potential elements at risk, their corresponding damage potentials and the Probable Maximum Losses (PMLs) of extreme natural hazards events in Tyrol (Austria) and considers adequatly the scale dependency and balanced application of the introduced risk components. Beside the introduced analysis an additionally portfolio analysis of a regional insurance company was executed. The geocoded insurance contracts of this portfolio analysis were the basis to estimate spatial, socio-economical and functional differentiated mean insurance values for the different risk categories of (i) buildings, (ii) contents or inventory, (iii) vehicles, and (iv) persons in the study area. The estimated mean insurance values were

Chemical modification of jute fibers for the production of green-composites

Energy Technology Data Exchange (ETDEWEB)

Corrales, F. [Group Lepamap, Department of Chemical Engineering, University of Girona, Girona 17071 (Spain)]. E-mail: farners.corrales@udg.es; Vilaseca, F. [Group Lepamap, Department of Chemical Engineering, University of Girona, Girona 17071 (Spain); Llop, M. [Group Lepamap, Department of Chemical Engineering, University of Girona, Girona 17071 (Spain); Girones, J. [Group Lepamap, Department of Chemical Engineering, University of Girona, Girona 17071 (Spain); Mendez, J.A. [Group Lepamap, Department of Chemical Engineering, University of Girona, Girona 17071 (Spain); Mutje, P. [Group Lepamap, Department of Chemical Engineering, University of Girona, Girona 17071 (Spain)

2007-06-18

Natural fiber reinforced composites is an emerging area in polymer science. Fibers derived from annual plants are considered a potential substitute for non-renewable synthetic fibers like glass and carbon fibers. The hydrophilic nature of natural fibers affects negatively its adhesion to hydrophobic polymeric matrices. To improve the compatibility between both components a surface modification has been proposed. The aim of the study is the chemical modification of jute fibers using a fatty acid derivate (oleoyl chloride) to confer hydrophobicity and resistance to biofibers. This reaction was applied in swelling and non-swelling solvents, pyridine and dichloromethane, respectively. The formation of ester groups, resulting from the reaction of oleoyl chloride with hydroxyl group of cellulose were studied by elemental analysis (EA) and Fourier Transform infrared spectroscopy (FTIR). The characterization methods applied has proved the chemical interaction between the cellulosic material and the coupling agent. The extent of the reactions evaluated by elemental analysis was calculated using two ratios. Finally electron microscopy was applied to evaluate the surface changes of cellulose fibers after modification process.

Thermal biology mediates responses of amphibians and reptiles to habitat modification.

Science.gov (United States)

Nowakowski, A Justin; Watling, James I; Thompson, Michelle E; Brusch, George A; Catenazzi, Alessandro; Whitfield, Steven M; Kurz, David J; Suárez-Mayorga, Ángela; Aponte-Gutiérrez, Andrés; Donnelly, Maureen A; Todd, Brian D

2018-03-01

Human activities often replace native forests with warmer, modified habitats that represent novel thermal environments for biodiversity. Reducing biodiversity loss hinges upon identifying which species are most sensitive to the environmental conditions that result from habitat modification. Drawing on case studies and a meta-analysis, we examined whether observed and modelled thermal traits, including heat tolerances, variation in body temperatures, and evaporative water loss, explained variation in sensitivity of ectotherms to habitat modification. Low heat tolerances of lizards and amphibians and high evaporative water loss of amphibians were associated with increased sensitivity to habitat modification, often explaining more variation than non-thermal traits. Heat tolerances alone explained 24-66% (mean = 38%) of the variation in species responses, and these trends were largely consistent across geographic locations and spatial scales. As habitat modification alters local microclimates, the thermal biology of species will likely play a key role in the reassembly of terrestrial communities. © 2018 John Wiley & Sons Ltd/CNRS.

Particle size - An important factor in environmental consequence modeling

International Nuclear Information System (INIS)

Yuan, Y.C.; MacFarlane, D.

1991-01-01

Most available environmental transport and dosimetry codes for radiological consequence analysis are designed primarily for estimating dose and health consequences to specific off-site individuals as well as the population as a whole from nuclear facilities operating under either normal or accident conditions. Models developed for these types of analyses are generally based on assumptions that the receptors are at great distances (several kilometers), and the releases are prolonged and filtered. This allows the use of simplified approaches such as averaged meteorological conditions and the use of a single (small) particle size for atmospheric transport and dosimetry analysis. Source depletion from particle settling, settle-out, and deposition is often ignored. This paper estimates the effects of large particles on the resulting dose consequences from an atmospheric release. The computer program AI-RISK has been developed to perform multiparticle-sized atmospheric transport, dose, and pathway analyses for estimating potential human health consequences from the accidental release of radioactive materials. The program was originally developed to facilitate comprehensive analyses of health consequences, ground contamination, and cleanup associated with possible energetic chemical reactions in high-level radioactive waste (HLW) tanks at a US Department of Energy site

Effect of Terminal Modification on the Molecular Assembly and Mechanical Properties of Protein-Based Block Copolymers.

Science.gov (United States)

Jacobsen, Matthew M; Tokareva, Olena S; Ebrahimi, Davoud; Huang, Wenwen; Ling, Shengjie; Dinjaski, Nina; Li, David; Simon, Marc; Staii, Cristian; Buehler, Markus J; Kaplan, David L; Wong, Joyce Y

2017-09-01

Accurate prediction and validation of the assembly of bioinspired peptide sequences into fibers with defined mechanical characteristics would aid significantly in designing and creating materials with desired properties. This process may also be utilized to provide insight into how the molecular architecture of many natural protein fibers is assembled. In this work, computational modeling and experimentation are used in tandem to determine how peptide terminal modification affects a fiber-forming core domain. Modeling shows that increased terminal molecular weight and hydrophilicity improve peptide chain alignment under shearing conditions and promote consolidation of semicrystalline domains. Mechanical analysis shows acute improvements to strength and elasticity, but significantly reduced extensibility and overall toughness. These results highlight an important entropic function that terminal domains of fiber-forming peptides exhibit as chain alignment promoters, which ultimately has notable consequences on the mechanical behavior of the final fiber products. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Development of a Methodology for VHTR Accident Consequence Assessment

Energy Technology Data Exchange (ETDEWEB)

Lee, Joeun; Kim, Jintae; Jae, Moosung [Hanyang University, Seoul (Korea, Republic of)

2016-05-15

The substitution of the VHTR for burning fossil fuels conserves these hydrocarbon resources for other uses and eliminates the emissions of greenhouse. In Korea, for these reasons, constructing the VHTR plan for hydrogen production is in progress. In this study, the consequence analysis for the off-site releases of radioactive materials during severe accidents has been performed using the level 3 PRA technology. The offsite consequence analysis for a VHTR using the MACCS code has been performed. Since the passive system such as the RCCS(Reactor Cavity Cooling System) are equipped, the frequency of occurrence of accidents has been evaluated to be very low. For further study, the assessment for characteristic of VHTR safety system and precise quantification of its accident scenarios is expected to conduct more certain consequence analysis. This methodology shown in this study might contribute to enhancing the safety of VHTR design by utilizing the results having far lower effect on the environment than the LWRs.

Consequence of potential accidents in heavy water plants

International Nuclear Information System (INIS)

Croitoru, C.; Lazar, R.E.; Preda, I.A.; Dumitrescu, M.

1998-01-01

Heavy water plants realize the primary isotopic concentrations of water using H 2 O-H 2 S chemical exchange and they are chemical plants. As these plants are handling and spreading large quantities of hydrogen sulphide (high toxic, corrosive, flammable and explosive as) maintained in the process at relative high temperatures and pressures, it is required an assessing of risks associated with the potential accidents. The H 2 S released in atmosphere as a result of an accident will have negative consequences to property, population and environment. This paper presents a model of consequences quantitative assessment and its outcome for the most dangerous accident in heavy water plants. Several states of the art risk based methods were modified and linked together to form a proper model for this analyse. Five basic steps to identify the risks involved in operating the plants are followed: hazard identification, accident sequence development, H 2 S emissions calculus, dispersion analyses and consequences determination. A brief description of each step and some information of analysis results are provided. The accident proportions, the atmospheric conditions and the population density in the respective area were accounted for consequences calculus. The specific results of the consequences analysis allow to develop the plant's operating safety requirements so that the risk remain at an acceptable level. (authors)

Chronic exposure to glufosinate-ammonium induces spatial memory impairments, hippocampal MRI modifications and glutamine synthetase activation in mice.

Science.gov (United States)

Calas, André-Guilhem; Richard, Olivier; Même, Sandra; Beloeil, Jean-Claude; Doan, Bich-Thuy; Gefflaut, Thierry; Même, William; Crusio, Wim E; Pichon, Jacques; Montécot, Céline

2008-07-01

Glufosinate-ammonium (GLA), the active compound of a worldwide-used herbicide, acts by inhibiting the plant glutamine synthetase (GS) leading to a lethal accumulation of ammonia. GS plays a pivotal role in the mammalian brain where it allows neurotransmitter glutamate recycling within astroglia. Clinical studies report that an acute GLA ingestion induces convulsions and memory impairment in humans. Toxicological studies performed at doses used for herbicidal activity showed that GLA is probably harmless at short or medium range periods. However, effects of low doses of GLA on chronically exposed subjects are not known. In our study, C57BL/6J mice were treated during 10 weeks three times a week with 2.5, 5 and 10mg/kg of GLA. Effects of this chronic treatment were assessed at behavioral, structural and metabolic levels by using tests of spatial memory, locomotor activity and anxiety, hippocampal magnetic resonance imaging (MRI) texture analysis, and hippocampal GS activity assay, respectively. Chronic GLA treatments have effects neither on anxiety nor on locomotor activity of mice but at 5 and 10mg/kg induce (1) mild memory impairments, (2) a modification of hippocampal texture and (3) a significant increase in hippocampal GS activity. It is suggested that these modifications may be causally linked one to another. Since glutamate is the main neurotransmitter in hippocampus where it plays a crucial role in spatial memory, hippocampal MRI texture and spatial memory alterations might be the consequences of hippocampal glutamate homeostasis modification revealed by increased GS activity in hippocampus. The present study provides the first data that show cerebral alterations after chronic exposure to GLA.

Research on consequence analysis method for probabilistic safety assessment of nuclear fuel facilities (4). Investigation of safety evaluation method for fire and explosion incidents

International Nuclear Information System (INIS)

Abe, Hitoshi; Tashiro, Shinsuke; Ueda, Yoshinori

2010-01-01

A special committee on 'Research on the analysis methods for accident consequence of nuclear fuel facilities (NFFs)' was organized by the Atomic Energy Society of Japan (AESJ) under the entrustment of Japan Atomic Energy Agency (JAEA). The committee aims to research on the state-of-the-art consequence analysis method for Probabilistic Safety Assessment (PSA) of NFFs, such as fuel reprocessing and fuel fabrication facilities. The objective of this research is to obtain the useful information related to the establishment of quantitative performance objectives and to risk-informed regulation through qualifying issues needed to be resolved for applying PSA to NFFs. The research activities of the committee were mainly focused on the analysis method of consequences for postulated accidents with potentially large consequences in NFFs, e.g., events of criticality, spill of molten glass, hydrogen explosion, boiling of radioactive solution, and fire (including rapid decomposition of TBP complexes), resulting in the release of radio active materials into the environment. The results of the research were summarized in a series of six reports, which consist of a review report and five technical ones. In this technical report, the research results about basic experimental data and the method for safety evaluation of fire and explosion incidents were summarized. (author)

Labor Migration from Ukraine to the EU: an Analysis of Characteristics and Consequences

Directory of Open Access Journals (Sweden)

Bezrukova Nataliya V.

2016-02-01

Full Text Available The article is aimed at analyzing characteristics of labor migration from Ukraine to the European Union and evaluating the possible consequences of this process, as well as determining the future development trends in terms of emigration from Ukraine. The main directions of labor migration from Ukraine have been examined. An estimation of the volume of labor migration has been provided. Data about the socio-demographic characteristics of migrants have been presented. It is specified that the process of emigration has both positive and negative consequences for our country. Particular attention is paid to the analysis of employment settings of migrants in the Member States of the European Union. The main causes of emigration from Ukraine, among which both unemployment and low wages, have been allocated. The authors prove that the average monthly salary of Ukrainian migrants in the EU Member States is much higher than in Ukraine. On the basis of the carried out study has been concluded that labor migration from Ukraine to the EU has important socio-economic importance to our State. At the same time, signing of the Association agreement between Ukraine, on the one hand, and the European Union, the European Atomic Energy Community and their Member States, on the other hand, as well as introduction of a visa-free regime, will contribute to an increase in the number of labor migrants.

The management of modifications

International Nuclear Information System (INIS)

Bernard, C.

1992-01-01

Description of the management methods of modifications at EDF. To maintain safety standards of the nuclear power station the 'Direction de l'Equipment' and the 'Direction du Parc en Exploitation' have jointly fixed the modalities of management for all modifications and recorded them in a 'Practical Guide'

Centrifugal compressor shape modification using a proposed inverse design method

International Nuclear Information System (INIS)

Niliahmadabadi, Mahdi; Poursadegh, Farzad

2013-01-01

This paper is concerned with a quasi-3D design method for the radial and axial diffusers of a centrifugal compressor on the meridional plane. The method integrates a novel inverse design algorithm, called ball-spine algorithm (BSA), and a quasi-3D analysis code. The Euler equation is solved on the meridional plane for a numerical domain, of which unknown boundaries (hub and shroud) are iteratively modified under the BSA until a prescribed pressure distribution is reached. In BSA, unknown walls are composed of a set of virtual balls that move freely along specified directions called spines. The difference between target and current pressure distributions causes the flexible boundary to deform at each modification step. In validating the quasi-3D analysis code, a full 3D Navier-Stokes code is used to analyze the existing and designed compressors numerically. Comparison of the quasi-3D analysis results with full 3D analysis results shows viable agreement. The 3D numerical analysis of the current compressor shows a huge total pressure loss on the 90 .deg. bend between the radial and axial diffusers. Geometric modification of the meridional plane causes the efficiency to improve by about 10%.

Centrifugal compressor shape modification using a proposed inverse design method

Energy Technology Data Exchange (ETDEWEB)

Niliahmadabadi, Mahdi [Isfahan University of Technology, Isfahan (Iran, Islamic Republic of); Poursadegh, Farzad [Sharif University of Technology, Tehran (Iran, Islamic Republic of)

2013-03-15

This paper is concerned with a quasi-3D design method for the radial and axial diffusers of a centrifugal compressor on the meridional plane. The method integrates a novel inverse design algorithm, called ball-spine algorithm (BSA), and a quasi-3D analysis code. The Euler equation is solved on the meridional plane for a numerical domain, of which unknown boundaries (hub and shroud) are iteratively modified under the BSA until a prescribed pressure distribution is reached. In BSA, unknown walls are composed of a set of virtual balls that move freely along specified directions called spines. The difference between target and current pressure distributions causes the flexible boundary to deform at each modification step. In validating the quasi-3D analysis code, a full 3D Navier-Stokes code is used to analyze the existing and designed compressors numerically. Comparison of the quasi-3D analysis results with full 3D analysis results shows viable agreement. The 3D numerical analysis of the current compressor shows a huge total pressure loss on the 90 .deg. bend between the radial and axial diffusers. Geometric modification of the meridional plane causes the efficiency to improve by about 10%.

Analysis of Modifications on a Spark Ignition Engine for Operation with Natural Gas

Directory of Open Access Journals (Sweden)

Ramasamy D.

2016-01-01

Full Text Available Transportation is one of the key contributors to petroleum usage and emissions to the atmosphere. According to researchers, there are many ways to use transport by using renewable energy sources. Of these solutions, the immediate solution which requires less modification to current engine technology is by using gaseous fuels. Natural gas is the fuel of choice for minor modification to current engines. As it can be derived from anaerobic digestion process, the potential as a renewable energy source is tremendous, especially for an agricultural country such a Malaysia. The aim in the future will be operating an engine with natural gas only with pipelines straight to houses for easy filling. The fuel is light and can be easily carried in vehicles when in compressed form. As such, Compressed Natural Gas (CNG is currently used in bi-fuel engines, but is mostly not optimized in term of their performance. The focus of the paper is to optimize a model of natural gas engine by one dimensional flow modeling for operation with natural gas. The model is analyzed for performance and emission characteristics produced by a gasoline engine and later compared with natural gas. The average performance drop is about 15% from its gasoline counterpart. The 4% benchmark indicates that the modification to ignition timing and compression ratio does improve engine performance using natural gas as fuel.

How the causes, consequences and solutions for problem gambling are reported in Australian newspapers: a qualitative content analysis.

Science.gov (United States)

Miller, Helen E; Thomas, Samantha L; Robinson, Priscilla; Daube, Mike

2014-12-01

To inform public health approaches to problem gambling by examining how the news media covers problem gambling, with a particular focus on the causes, consequences and solutions to problem gambling, and the 'actors' and sources who influence media coverage. A qualitative content analysis guided by framing theory analysed coverage of problem gambling in Australian newspapers in the period 1 July 2011 to 30 June 2012. Solutions to problem gambling were more frequently discussed than causes and consequences. A focus on the responsibility of individuals was preferred to reporting that focused on broader social, ecological, and industry determinants of problem gambling. Reporting was highly politicised, with politicians frequently quoted and political issues frequently discussed. In contrast, the community sector, health professionals and problem gamblers were rarely quoted. This analysis has revealed the need for a more proactive, coordinated approach to the media by both public health researchers and health groups. The establishment of a gambling-specific coalition to push for evidence-based reform is recommended. © 2014 Public Health Association of Australia.

Conceptual design report of hot cell modification and process for fission Mo-99 production

International Nuclear Information System (INIS)

Park, Jin Ho; Choung, W. M.; Lee, K. I.; Hwang, D. S.; Kim, Y. K.; Park, K. B.; Jung, Y. J.; Kim, D. S.; Park, Y. C.

2001-05-01

In this conceptual design report, the basic data and design guides for detail design of fission Mo-99 production process and hot cell modification are included.The basic data and design guides for detail design of fission Mo-99 production process contains following contents. -design capacity, the basic process, process flow diagram, process material balance, process data. The basic data and design guides for modification of existing hot cell contains following contents. - plot plan of hot cell facility, the plan for shield reinforcement of hot cell, the plan for management and storage of high level liquid wastes, the plan of ventilation system, the plan for modification of auxiliary facilities. And also, the results of preliminary safety analysis(normal operation and accidents) and criticality analysis are included in this conceptual design report

Conceptual design report of hot cell modification and process for fission Mo-99 production

Energy Technology Data Exchange (ETDEWEB)

Park, Jin Ho; Choung, W. M.; Lee, K. I.; Hwang, D. S.; Kim, Y. K.; Park, K. B.; Jung, Y. J.; Kim, D. S.; Park, Y. C

2001-05-01

In this conceptual design report, the basic data and design guides for detail design of fission Mo-99 production process and hot cell modification are included.The basic data and design guides for detail design of fission Mo-99 production process contains following contents. -design capacity, the basic process, process flow diagram, process material balance, process data. The basic data and design guides for modification of existing hot cell contains following contents. - plot plan of hot cell facility, the plan for shield reinforcement of hot cell, the plan for management and storage of high level liquid wastes, the plan of ventilation system, the plan for modification of auxiliary facilities. And also, the results of preliminary safety analysis(normal operation and accidents) and criticality analysis are included in this conceptual design report.

Probabilistic risk assessment course documentation. Volume 7. Environmental transport and consequence analysis

International Nuclear Information System (INIS)

Ritchie, L.T.; Alpert, D.J.; Burke, R.P.; Ostmeyer, R.M.; Kaiser, G.D.; Runkle, G.E.; Woodard, K.

1985-08-01

Consequence models have been designed to assess health and economic risks from potential accidents at nuclear power plants. These models have been applied to an ever increasing variety of problems with ever increasing demands to improve modeling capabilities and provide greater realism. This course discusses the environmental transport of postulated radiological releases and the elements and purpose of accident consequence evaluation

Virtual Instruments for the Circuit Analysis with Interactive Parameter Modification

Directory of Open Access Journals (Sweden)

Eberhard Stefan Brenner

2006-08-01

Full Text Available Abstract—The contribution presents the possibilities of LabVIEW in the special application as formula interpreter by using of the formula node. The main advantage is the immediate presentation of results in case of a parameter modification. The presentation of the time behaviour, the calculation of characteristic values and curves for typical examples of power electronics and control engineering are shown. Index Terms—Education; Formula Interpretation; LabVIEW; Power Electronics; Virtual Instruments

Analysis of various modifications in spectra analysis on accuracy of dose reconstructions in EPR dosimetry in tooth enamel

Energy Technology Data Exchange (ETDEWEB)

Ciesielski, B., E-mail: bciesiel@gumed.edu.pl [Department of Physics and Biophysics, Medical University of Gdansk, Debinki 1, 80-211 Gdansk (Poland); Kaminska, J. [Department of Oncology and Radiotherapy, Medical University of Gdansk, Debinki 7, 80-211 Gdansk (Poland); Emerich, K. [Department of Paediatric Dentistry, Medical University of Gdansk, Orzeszkowej 18, 80-208 Gdansk (Poland)

2011-09-15

The results of EPR measurements performed due to our participation in the 4th International Comparison of EPR Dosimetry using tooth enamel were used to analyze the effects of modifications in numerical analysis of the measured spectra on precision and accuracy of reconstructed doses. The studied modifications included effects of: (1) a use of Mn{sup 2+} standard, (2) variations in experimental native background signals of tooth enamel used for dose reconstructions, (3) signal filtration, (4) subtraction of empty tube spectra, and (5) variations in the spectra ranges used for calculations (fitting windows). It was shown, that the use of a Mn standard, for normalization of intensities of the recorded signals in the spectra processing, strongly increased the dosimetric accuracy. The regression lines of the doses reconstructed using different background spectra against nominal doses, obtained without Mn standard, had slopes about 30% higher and their scatter range was about 2 times higher than the same parameters obtained when Mn standard was applied in the spectra processing. Accuracy of the measured doses characterized by root mean square deviations from the nominal doses was 71 mGy for calculations with Mn standard and 241 mGy without normalization to Mn lines. Despite the large beneficial effect of the use of Mn standard on accuracy (root mean square deviations of the data, slope of the regression lines), it did not significantly improve the dosimetry performance characterized by the critical dose and detection limit. The smoothing of the spectra by 9 point filtration resulted in 1.6% increase of the reconstructed doses. The subtraction of empty tube spectrum had no effect on precision and accuracy of the dose reconstruction. The performance parameters were also practically insensitive to a choice of a width of the spectral window used for the analysis, provided it encompassed the {approx}1.6 mT range covering the main peaks of the radiation induced signal in

Panel on atmospheric and climatic consequences

International Nuclear Information System (INIS)

Anon.

1984-01-01

This article reviews some of the important details and undergirding of the presentations on the atmospheric, climatic and biological consequences of nuclear war. The discussion focuses on two questions that have been raised: whether the scenerios that have been presented are a credible basis for analysis of the consequences of possible nuclear wars, given the sizes of the existing arsenals and the available knowledge about how these arsenals might be used; and, whether the various numbers that were given for radiation doses from fallout are in fact internally consistent and compatible with those calculated by other analysts

Uncertainty and sensitivity analysis of food pathway results with the MACCS Reactor Accident Consequence Model

International Nuclear Information System (INIS)

Helton, J.C.; Johnson, J.D.; Rollstin, J.A.; Shiver, A.W.; Sprung, J.L.

1995-01-01

Uncertainty and sensitivity analysis techniques based on Latin hypercube sampling, partial correlation analysis and stepwise regression analysis are used in an investigation with the MACCS model of the food pathways associated with a severe accident at a nuclear power station. The primary purpose of this study is to provide guidance on the variables to be considered in future review work to reduce the uncertainty in the important variables used in the calculation of reactor accident consequences. The effects of 87 imprecisely-known input variables on the following reactor accident consequences are studied: crop growing season dose, crop long-term dose, milk growing season dose, total food pathways dose, total ingestion pathways dose, total long-term pathways dose, area dependent cost, crop disposal cost, milk disposal cost, condemnation area, crop disposal area and milk disposal area. When the predicted variables are considered collectively, the following input variables were found to be the dominant contributors to uncertainty: fraction of cesium deposition on grain fields that is retained on plant surfaces and transferred directly to grain, maximum allowable ground concentrations of Cs-137 and Sr-90 for production of crops, ground concentrations of Cs-134, Cs-137 and I-131 at which the disposal of milk will be initiated due to accidents that occur during the growing season, ground concentrations of Cs-134, I-131 and Sr-90 at which the disposal of crops will be initiated due to accidents that occur during the growing season, rate of depletion of Cs-137 and Sr-90 from the root zone, transfer of Sr-90 from soil to legumes, transfer of Cs-137 from soil to pasture, transfer of cesium from animal feed to meat, and the transfer of cesium, iodine and strontium from animal feed to milk

Uncertainty and sensitivity analysis of food pathway results with the MACCS reactor accident consequence model

International Nuclear Information System (INIS)

Helton, J.C.; Johnson, J.D.; Rollstin, J.A.; Shiver, A.W.; Sprung, J.L.

1995-01-01

Uncertainty and sensitivity analysis techniques based on Latin hypercube sampling, partial correlation analysis and stepwise regression analysis are used in an investigation with the MACCS model of the food pathways associated with a severe accident at a nuclear power station. The primary purpose of this study is to provide guidance on the variables to be considered in future review work to reduce the uncertainty in the important variables used in the calculation of reactor accident consequences. The effects of 87 imprecisely-known input variables on the following reactor accident consequences are studied: crop growing-season dose, crop long-term dose, milk growing-season dose, total food pathways dose, total ingestion pathways dose, total long-term pathways dose, area dependent cost, crop disposal cost, milk disposal cost, condemnation area, crop disposal area and milk disposal area. When the predicted variables are considered collectively, the following input variables were found to be the dominant contributors to uncertainty: fraction of cesium deposition on grain fields that is retained on plant surfaces and transferred directly to grain, maximum allowable ground concentrations of Cs-137 and Sr-90 for production of crops, ground concentrations of Cs-134, Cs-137 and I-131 at which the disposal of milk will be initiated due to accidents that occur during the growing season, ground concentrations of Cs-134, I-131 and Sr-90 at which the disposal of crops will be initiated due to accidents that occur during the growing season, rate of depletion of Cs-137 and Sr-90 from the root zone, transfer of Sr-90 from soil to legumes, transfer of Cs-137 from soil to pasture, transfer of cesium from animal feed to meat, and the transfer of cesium, iodine and strontium from animal feed to milk

Research on consequence analysis method for probabilistic safety assessment of nuclear fuel facilities (5). Evaluation method and trial evaluation of criticality accident

International Nuclear Information System (INIS)

Yamane, Yuichi; Abe, Hitoshi; Nakajima, Ken; Hayashi, Yoshiaki; Arisawa, Jun; Hayami, Satoru

2010-01-01

A special committee of 'Research on the analysis methods for accident consequence of nuclear fuel facilities (NFFs)' was organized by the Atomic Energy Society of Japan (AESJ) under the entrustment of Japan Atomic Energy Agency (JAEA). The committee aims to research on the state-of-the-art consequence analysis method for the Probabilistic Safety Assessment (PSA) of NFFs, such as fuel reprocessing and fuel fabrication facilities. The objectives of this research are to obtain information useful for establishing quantitative performance objectives and to demonstrate risk-informed regulation through qualifying issues needed to be resolved for applying PSA to NFFs. The research activities of the committee were mainly focused on the consequence analysis method for postulated accidents with potentially large consequences in NFFs, e.g., events of criticality, spill of molten glass, hydrogen explosion, boiling of radioactive solution and fire (including the rapid decomposition of TBP complexes), resulting in the release of radioactive materials to the environment. The results of the research were summarized in a series of six reports, which consist of a review report and five technical ones. In this report, the evaluation methods of criticality accident, such as simplified methods, one-point reactor kinetics codes and quasi-static method, were investigated and their features were summarized to provide information useful for the safety evaluation of NFFs. In addition, several trial evaluations were performed for a hypothetical scenario of criticality accident using the investigated methods, and their results were compared. The release fraction of volatile fission products in a criticality accident was also investigated. (author)

Cell Signalling Through Covalent Modification and Allostery

Science.gov (United States)

Johnson, Louise N.

Phosphorylation plays essential roles in nearly every aspect of cell life. Protein kinases catalyze the transfer of the γ-phosphate of ATP to a serine, threonine or tyrosine residue in protein substrates. This covalent modification allows activation or inhibition of enzyme activity, creates recognition sites for other proteins and promotes order/disorder or disorder/order transitions. These properties regulate ­signalling pathways and cellular processes that mediate metabolism, transcription, cell cycle progression, differentiation, cytoskeleton arrangement and cell movement, apoptosis, intercellular communication, and neuronal and immunological functions. In this lecture I shall review the structural consequences of protein phosphorylation using our work on glycogen phosphorylase and the cell cycle cyclin dependent protein kinases as illustrations. Regulation of protein phosphorylation may be disrupted in the diseased state and protein kinases have become high profile targets for drug development. To date there are 11 compounds that have been approved for clinical use in the treatment of cancer.

Shielding modification and safety review on the nuclear ship 'Mutsu'

International Nuclear Information System (INIS)

Osanai, Masao

1978-01-01

The Japan Atomic Energy Commission (JAEC) called on the Japan Nuclear Ship Development Agency (JNSDA) for shielding modification and safety review on the nuclear ship ''Mutsu'', and JNSDA has conducted the research and development (R and D) to meet the request of JAEC for the above two items. Concerning the shield modification, the following matters are described: the study on the cause of radiation leakage which was concluded to the fast neutron streaming, the conceptual design for this modification, the mock up experiment for shielding utilizing JRR-4, the basic design following on the conceptual design, including the detailed drawings of the modified construction and the shielding analysis using RADHEAT-V3 code, and the relating experiments such as the heat transfer test of the primary shielding structure and the test of strength in stranding. As for the safety review, the survey of the troubles and the technical problems having been experienced in the light water reactor plants of land use, for example, fuel integrity, stress corrosion cracking and the leakage of steam generator tubes, the revision of the design so as to adapt to current safety standards and regulations, for example, in-service inspection, the setting of additional leak detectors in the primary cooling system, the modification of emergeney filters, etc., and the review of the design and construction corresponding to recent R and D works, such as re-evaluation of the core design, cooling capability of natural circulation, thermal stress analysis of main pipings, and the evaluation of ECCS performance are presented . (Nakai, Y.)

Human Rights and Behavior Modification

Science.gov (United States)

Roos, Philip

1974-01-01

Criticisms of behavior modification, which charge that it violates ethical and legal principles, are discussed and reasons are presented to explain behavior modification's susceptibility to attack. (GW)

HVAC modifications and computerized energy analysis for the Operations Support Building at the Mars Deep Space Station at Goldstone

Science.gov (United States)

Halperin, A.; Stelzmuller, P.

1986-01-01

The key heating, ventilation, and air-conditioning (HVAC) modifications implemented at the Mars Deep Space Station's Operation Support Building at Jet Propulsion Laboratories (JPL) in order to reduce energy consumption and decrease operating costs are described. An energy analysis comparison between the computer simulated model for the building and the actual meter data was presented. The measurement performance data showed that the cumulative energy savings was about 21% for the period 1979 to 1981. The deviation from simulated data to measurement performance data was only about 3%.

Chronic Δ⁸-THC Exposure Differently Affects Histone Modifications in the Adolescent and Adult Rat Brain.

Science.gov (United States)

Prini, Pamela; Penna, Federica; Sciuccati, Emanuele; Alberio, Tiziana; Rubino, Tiziana

2017-10-04

Adolescence represents a vulnerable period for the psychiatric consequences of delta9-tetrahydrocannabinol (Δ⁸-THC) exposure, however, the molecular underpinnings of this vulnerability remain to be established. Histone modifications are emerging as important epigenetic mechanisms involved in the etiopathogenesis of psychiatric diseases, thus, we investigated the impact of chronic Δ⁸-THC exposure on histone modifications in different brain areas of female rats. We checked histone modifications associated to both transcriptional repression (H3K9 di- and tri-methylation, H3K27 tri-methylation) and activation (H3K9 and H3K14 acetylation) after adolescent and adult chronic Δ⁸-THC exposure in the hippocampus, nucleus accumbens, and amygdala. Chronic exposure to increasing doses of Δ⁸-THC for 11 days affected histone modifications in a region- and age-specific manner. The primary effect in the adolescent brain was represented by changes leading to transcriptional repression, whereas the one observed after adult treatment led to transcriptional activation. Moreover, only in the adolescent brain, the primary effect was followed by a homeostatic response to counterbalance the Δ⁸-THC-induced repressive effect, except in the amygdala. The presence of a more complex response in the adolescent brain may be part of the mechanisms that make the adolescent brain vulnerable to Δ⁸-THC adverse effects.

Improving the antimicrobial properties of titanium condenser material by surface modification using nanotechnology

International Nuclear Information System (INIS)

George, Rani P.; Dash, S.; Krishnan, R.; Kamruddin, M.; Kalavathi, S.; Tyagi, A.K.; Manoharan, N.; Dayal, R.K.; Vishwakarma, Vinita; Theresa, Josephine

2008-01-01

Biofouling is one of the major problems faced by condenser materials of power plants using seawater for cooling. Fouling control strategies in condensers include a combination of mechanical and chemical treatments like sponge ball cleaning, back washing and chlorination. In general, numerous studies have shown that no routine treatment regime can successfully keep the condenser tube clean over a period extending to years. Surface properties of the substratum influence initial adhesion and growth of bacterial cells on materials, modification of the surface for mitigating microbial attachment is the need of the hour. Metal nanoparticles are known to exhibit enhanced physical and chemical properties when compared to their bulk counter parts because of their high surface to volume ratios. Metals like copper are very toxic to microorganisms and effectively kill most of the microbes by blocking the respiratory enzyme. Copper alloys with their excellent resistance to biofouling are used extensively for marine applications. However, they are prone to localized corrosion initiation and consequently are getting replaced by extremely corrosion resistant titanium. Still, the inertness and biocompatibility of titanium makes it very susceptible to biofouling. Hence, this study attempts to use nano technology methods of surface modification of titanium using thin film of copper and also multilayers and bilayers of copper and nickel. This is aimed at improving the antimicrobial properties of this condenser pipe material. These nano structured thin films have been grown on titanium substrate using pulsed DC magnetron-sputtering and pulsed laser deposition. The thin films were characterized using Atomic Force Microscopy (AFM), Glancing Incidence X-ray Diffraction (GIXRD) and scanning electron microscopy (SEM with EDAX analysis). Antimicrobial properties were evaluated by exposure studies in seawater and bacterial cultures and by post exposure analysis using culture and

Thermophysical properties of solid lithium hydride and its isotopic modifications

International Nuclear Information System (INIS)

Mel'nikova, T.N.

1981-01-01

The theory of the anharmonic lattice is used to calculate the thermophysical properties (thermal expansivity, lattice constant, compressibility, and elastic moduli) of all the isotopic modifications of solid lithium hydride sup(6,7)Li(H,D,T) at temperatures up to the melting point. A general analysis of isotopic effects is carried out; in particular the reverse isotopic effect in the lattice constant is explained and the isotopic effect in melting is discussed. The results of the calculations agree with available experimental data and can be used for those isotopic modifications of lithium hydride for which there exist no experimental results. (author)

Proteins from Erwinia asparaginase Erwinase ® and E. coli asparaginase 2 MEDAC ® for treatment of human leukemia, show a multitude of modifications for which the consequences are completely unclear.

Science.gov (United States)

Bae, Narkhyun; Pollak, Arnold; Lubec, Gert

2011-07-01

L-Asparaginase from Erwinia chrysanthemi (ASPG_ERWCH; UniProtKB accession number P06608 (Erwinase(®))) and L-asparaginase 2 from Escherichia coli (ASPG2_ECOLI; UniProtKB accession number P00805 (Medac(®))), both L-asparagine amidohydrolases, are widely used for the treatment of acute lymphoblastic leukemia. A series of serious side effects have been reported and this warrants studies into the protein chemistry of the medical products sold. Mass spectrometry (MS) data on ASPG_ERWCH and ASPG2_ECOLI have not been published so far and herein a gel-based proteomics study was performed to provide information about sequence and modifications of the commercially available medical products. ASPG_ERWCH and ASPG2_ECOLI were applied onto two-dimensional gel electrophoresis, spots were in-gel digested with several proteases and resulting peptides and protein modifications were analysed by nano-ESI-LC-MS/MS. Four spots were observed for ASPG_ERWCH, six spots were observed for ASPG2_ECOLI and the identified proteins showed high sequence coverage without sequence conflicts. Several protein modifications including technical and posttranslational modifications were demonstrated. Protein modifications are known to change physicochemical, immunochemical, biological and pharmacological properties and results from this work may challenge re-designing of the product including possible removal of the modifications by the manufacturer because it is not known whether they are contributing to the serious adverse effects of the protein drug. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Application of the cause-consequence diagram method to static systems

International Nuclear Information System (INIS)

Andrews, J.D.; Ridley, L.M.

2002-01-01

In the last 30 years, various mathematical models have been used to identify the effect of component failures on the performance of a system. The most frequently used technique for system reliability assessment is Fault Tree Analysis (FTA) and a large proportion of its popularity can be attributed to the fact that it provides a very good documentation of the way that the system failure logic was developed. Exact quantification of the fault tree, however, can be problematic for very large systems and in such situations, approximations can be used. Alternatively, an exact result can be obtained via the conversion of the fault tree into a binary decision diagram (BDD). The BDD, however, loses all failure logic documentation during the conversion process. This paper outlines the use of the cause-consequence diagram method as a tool for system risk and reliability analysis. As with the FTA method, the cause-consequence diagram documents the failure logic of the system. In addition to this the cause-consequence diagram produces the exact failure probability in a very efficient calculation procedure. The cause-consequence diagram technique has been applied to a static system and shown to yield the same result as those produced by the solution of the equivalent fault tree and BDD. On the basis of this general rules have been devised for the correct construction of the cause-consequence diagram given a static system. The use of the cause-consequence method in this manner has significant implications in terms of efficiency of the reliability analysis and can be shown to have benefits for static systems

Behavior Modification in the Classroom

Science.gov (United States)

Whitman, Mryon; Whitman, Joan

1971-01-01

This article presents the theoretical rationale for behavior modification, principally through its comparison with traditional psychotherapies, and suggests some behavior modification techniques for the classroom management of maladaptive behavior. (Author)

Analysis the Human and Environmental Consequences of Power Pplants Using Combined Delphi and AHP Method

International Nuclear Information System (INIS)

Jozi, S. A.; Saffarian, Sh.; Shafiee, M.; Akbari, A.

2016-01-01

Power plants, due to the nature of their processes and activities and also by producing the effluents, emitting the air pollutants and hazardous wastes, have the potential to cause negative human and environmental consequences. Given the importance of the issue, for determining the most important consequences of Abadan Gas Power Plant and also their impact on the human and natural environment, as a case study, a questionnaire was developed with Delphi method. This questionnaire was distributed within the environmentalists and experts of power plant. The human and environmental consequences of Power Plant were analyzed by Multiple Criteria Decision-Making methods including AHP and eigenvector technique. For this purpose, with applying of AHP method, the hierarchical structure of the human and environmental consequences of Abadan Gas Power Plant was constructed and then the decision making matrix was formed. The pair wise matrices were formed separately for criteria pair wise comparisons with respect to severity and occurrence probability of indoor and outdoor environment of power plant .With entering the data in EXPERT CHOICE software, criteria weights were computed with applying the eigenvector method. Then the final weights of consequences in terms of severity and occurrence probability of risk were computed. The results from the compution of Abadan Gas Power Plant consequences indicate that in human consequences, shallow wounds with a .105 weight and in environmental consequences, air pollution by weighing 0.66 are the most important consequences of power plant. Finally, the most important executable strategies and actions for mitigation of negative human and environmental consequences were presented.

MODIFICATION OF PAPERMAKING GRADE FILLERS: A BRIEF REVIEW

Directory of Open Access Journals (Sweden)

Jing Shen

2009-08-01

Full Text Available The use of fillers in paper products can provide cost and energy savings, improved paper properties, increased productivities, and specifically desired paper functionalities. There are many problems associated with the use of fillers, such as unsuitability of calcium carbonate fillers in acid papermaking, negative effects of filler loading on paper strength, sizing, and retention, and tendencies of fillers to cause abrasion and dusting. In order to solve these problems and to make better use of fillers, many methods have been proposed, among which filler modification has been a hot topic. The available technologies of filler modification mainly include modification with inorganic substances, modification with natural polymers or their derivatives, modification with water-soluble synthetic polymers, modification with surfactants, modification with polymer latexes, hydrophobic modification, cationic modification, surface nano-structuring, physical modification by compressing, calcination or grinding, and modification for use in functional papers. The methods of filler modification can provide improved acid tolerant and optical properties of fillers, enhanced fiber-filler bonding, improved filler retention and filler sizabilities, alleviated filler abrasiveness, improved filler dispersability, and functionalization of filled papers. Filler modification has been an indispensable way to accelerate the development of high filler technology in papermaking, which is likely to create additional benefits to papermaking industry in the future.

PLMD: An updated data resource of protein lysine modifications.

Science.gov (United States)

Xu, Haodong; Zhou, Jiaqi; Lin, Shaofeng; Deng, Wankun; Zhang, Ying; Xue, Yu

2017-05-20

Post-translational modifications (PTMs) occurring at protein lysine residues, or protein lysine modifications (PLMs), play critical roles in regulating biological processes. Due to the explosive expansion of the amount of PLM substrates and the discovery of novel PLM types, here we greatly updated our previous studies, and presented a much more integrative resource of protein lysine modification database (PLMD). In PLMD, we totally collected and integrated 284,780 modification events in 53,501 proteins across 176 eukaryotes and prokaryotes for up to 20 types of PLMs, including ubiquitination, acetylation, sumoylation, methylation, succinylation, malonylation, glutarylation, glycation, formylation, hydroxylation, butyrylation, propionylation, crotonylation, pupylation, neddylation, 2-hydroxyisobutyrylation, phosphoglycerylation, carboxylation, lipoylation and biotinylation. Using the data set, a motif-based analysis was performed for each PLM type, and the results demonstrated that different PLM types preferentially recognize distinct sequence motifs for the modifications. Moreover, various PLMs synergistically orchestrate specific cellular biological processes by mutual crosstalks with each other, and we totally found 65,297 PLM events involved in 90 types of PLM co-occurrences on the same lysine residues. Finally, various options were provided for accessing the data, while original references and other annotations were also present for each PLM substrate. Taken together, we anticipated the PLMD database can serve as a useful resource for further researches of PLMs. PLMD 3.0 was implemented in PHP + MySQL and freely available at http://plmd.biocuckoo.org. Copyright © 2017 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Ltd. All rights reserved.

Immuno-Northern Blotting: Detection of RNA Modifications by Using Antibodies against Modified Nucleosides.

Directory of Open Access Journals (Sweden)

Eikan Mishima

Full Text Available The biological roles of RNA modifications are still largely not understood. Thus, developing a method for detecting RNA modifications is important for further clarification. We developed a method for detecting RNA modifications called immuno-northern blotting (INB analysis and herein introduce its various capabilities. This method involves the separation of RNAs using either polyacrylamide or agarose gel electrophoresis, followed by transfer onto a nylon membrane and subsequent immunoblotting using antibodies against modified nucleosides for the detection of specific modifications. We confirmed that INB with the antibodies for 1-methyladenosine (m1A, N6-methyladenosine (m6A, pseudouridine, and 5-methylcytidine (m5C showed different modifications in a variety of RNAs from various species and organelles. INB with the anti-m5C antibody revealed that the antibody cross-reacted with another modification on DNA, suggesting the application of this method for characterization of the antibody for modified nucleosides. Additionally, using INB with the antibody for m1A, which is a highly specific modification in eukaryotic tRNA, we detected tRNA-derived fragments known as tiRNAs under the cellular stress response, suggesting the application for tracking target RNA containing specific modifications. INB with the anti-m6A antibody confirmed the demethylation of m6A by the specific demethylases fat mass and obesity-associated protein (FTO and ALKBH5, suggesting its application for quantifying target modifications in separated RNAs. Furthermore, INB demonstrated that the knockdown of FTO and ALKBH5 increased the m6A modification in small RNAs as well as in mRNA. The INB method has high specificity, sensitivity, and quantitative capability, and it can be employed with conventional experimental apparatus. Therefore, this method would be useful for research on RNA modifications and metabolism.

Immuno-Northern Blotting: Detection of RNA Modifications by Using Antibodies against Modified Nucleosides.

Science.gov (United States)

Mishima, Eikan; Jinno, Daisuke; Akiyama, Yasutoshi; Itoh, Kunihiko; Nankumo, Shinnosuke; Shima, Hisato; Kikuchi, Koichi; Takeuchi, Yoichi; Elkordy, Alaa; Suzuki, Takehiro; Niizuma, Kuniyasu; Ito, Sadayoshi; Tomioka, Yoshihisa; Abe, Takaaki

2015-01-01

The biological roles of RNA modifications are still largely not understood. Thus, developing a method for detecting RNA modifications is important for further clarification. We developed a method for detecting RNA modifications called immuno-northern blotting (INB) analysis and herein introduce its various capabilities. This method involves the separation of RNAs using either polyacrylamide or agarose gel electrophoresis, followed by transfer onto a nylon membrane and subsequent immunoblotting using antibodies against modified nucleosides for the detection of specific modifications. We confirmed that INB with the antibodies for 1-methyladenosine (m1A), N6-methyladenosine (m6A), pseudouridine, and 5-methylcytidine (m5C) showed different modifications in a variety of RNAs from various species and organelles. INB with the anti-m5C antibody revealed that the antibody cross-reacted with another modification on DNA, suggesting the application of this method for characterization of the antibody for modified nucleosides. Additionally, using INB with the antibody for m1A, which is a highly specific modification in eukaryotic tRNA, we detected tRNA-derived fragments known as tiRNAs under the cellular stress response, suggesting the application for tracking target RNA containing specific modifications. INB with the anti-m6A antibody confirmed the demethylation of m6A by the specific demethylases fat mass and obesity-associated protein (FTO) and ALKBH5, suggesting its application for quantifying target modifications in separated RNAs. Furthermore, INB demonstrated that the knockdown of FTO and ALKBH5 increased the m6A modification in small RNAs as well as in mRNA. The INB method has high specificity, sensitivity, and quantitative capability, and it can be employed with conventional experimental apparatus. Therefore, this method would be useful for research on RNA modifications and metabolism.

Not just gene expression: 3D implications of chromatin modifications during sexual plant reproduction.

Science.gov (United States)

Dukowic-Schulze, Stefanie; Liu, Chang; Chen, Changbin

2018-01-01

DNA methylation and histone modifications are epigenetic changes on a DNA molecule that alter the three-dimensional (3D) structure locally as well as globally, impacting chromatin looping and packaging on a larger scale. Epigenetic marks thus inform higher-order chromosome organization and placement in the nucleus. Conventional epigenetic marks are joined by chromatin modifiers like cohesins, condensins and membrane-anchoring complexes to support particularly 3D chromosome organization. The most popular consequences of epigenetic modifications are gene expression changes, but chromatin modifications have implications beyond this, particularly in actively dividing cells and during sexual reproduction. In this opinion paper, we will focus on epigenetic mechanisms and chromatin modifications during meiosis as part of plant sexual reproduction where 3D management of chromosomes and re-organization of chromatin are defining features and prime tasks in reproductive cells, not limited to modulating gene expression. Meiotic chromosome organization, pairing and synapsis of homologous chromosomes as well as distribution of meiotic double-strand breaks and resulting crossovers are presumably highly influenced by epigenetic mechanisms. Special mobile small RNAs have been described in anthers, where these so-called phasiRNAs seem to direct DNA methylation in meiotic cells. Intriguingly, many of the mentioned developmental processes make use of epigenetic changes and small RNAs in a manner other than gene expression changes. Widening our approaches and opening our mind to thinking three-dimensionally regarding epigenetics in plant development holds high promise for new discoveries and could give us a boost for further knowledge.

Physical activity and exercise training in multiple sclerosis: a review and content analysis of qualitative research identifying perceived determinants and consequences.

Science.gov (United States)

Learmonth, Yvonne C; Motl, Robert W

2016-01-01

This systematic review was conducted to provide rich and deep evidence of the perceived determinants and consequences of physical activity and exercise based on qualitative research in multiple sclerosis (MS). Electronic databases and article reference lists were searched to identify qualitative studies of physical activity and exercise in MS. Studies were included if they were written in English and examined consequences/determinants of physical activity in persons with MS. Content analysis of perceived determinants and consequences of physical activity and exercise was undertaken using an inductive analysis guided by the Physical Activity for people with Disabilities framework and Social Cognitive Theory, respectively. Nineteen articles were reviewed. The most commonly identified perceived barriers of physical activity and exercise were related to the environmental (i.e. minimal or no disabled facilities, and minimal or conflicting advice from healthcare professionals) and related to personal barriers (i.e. fatigue, and fear and apprehension). The most commonly identified perceived facilitators of physical activity were related to the environment (i.e. the type of exercise modality and peer support) and related to personal facilitators (i.e. appropriate exercise and feelings of accomplishment). The most commonly identified perceived beneficial consequences of physical activity and exercise were maintaining physical functions, increased social participation and feelings of self-management and control. The most commonly identified perceived adverse consequences were increased fatigue and feelings of frustration and lost control. Results will inform future research on the perceived determinants and consequences of physical activity and exercise in those with MS and can be adopted for developing professional education and interventions for physical activity and exercise in MS. Physical activity and exercise behaviour in people with multiple sclerosis (MS) is subject

Do multiple body modifications alter pain threshold?

Science.gov (United States)

Yamamotová, A; Hrabák, P; Hříbek, P; Rokyta, R

2017-12-30

In recent years, epidemiological data has shown an increasing number of young people who deliberately self-injure. There have also been parallel increases in the number of people with tattoos and those who voluntarily undergo painful procedures associated with piercing, scarification, and tattooing. People with self-injury behaviors often say that they do not feel the pain. However, there is no information regarding pain perception in those that visit tattoo parlors and piercing studios compared to those who don't. The aim of this study was to compare nociceptive sensitivity in four groups of subjects (n=105, mean age 26 years, 48 women and 57 men) with different motivations to experience pain (i.e., with and without multiple body modifications) in two different situations; (1) in controlled, emotionally neutral conditions, and (2) at a "Hell Party" (HP), an event organized by a piercing and tattoo parlor, with a main event featuring a public demonstration of painful techniques (burn scars, hanging on hooks, etc.). Pain thresholds of the fingers of the hand were measured using a thermal stimulator and mechanical algometer. In HP participants, information about alcohol intake, self-harming behavior, and psychiatric history were used in the analysis as intervening variables. Individuals with body modifications as well as without body modifications had higher thermal pain thresholds at Hell Party, compared to thresholds measured at control neutral conditions. No such differences were found relative to mechanical pain thresholds. Increased pain threshold in all HP participants, irrespectively of body modification, cannot be simply explained by a decrease in the sensory component of pain; instead, we found that the environment significantly influenced the cognitive and affective component of pain.

Antecedents and Consequences of Individual Performance Analysis of Turnover Intention Model (Empirical Study of Public Accountants in Indonesia)

OpenAIRE

Raza, Hendra; Maksum, Azhar; Erlina; Lumban Raja, Prihatin

2014-01-01

Azhar Maksum This study aims to examine empirically the antecedents of individual performance on its consequences of turnover intention in public accounting firms. There are eight variables measured which consists of auditors' empowerment, innovation professionalism, role ambiguity, role conflict, organizational commitment, individual performance and turnover intention. Data analysis is based on 163 public accountant using the Structural Equation Modeling assisted with an appli...

Consequence Prioritization Process for Potential High Consequence Events (HCE)

Energy Technology Data Exchange (ETDEWEB)

Freeman, Sarah G. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2016-10-31

This document describes the process for Consequence Prioritization, the first phase of the Consequence-Driven Cyber-Informed Engineering (CCE) framework. The primary goal of Consequence Prioritization is to identify potential disruptive events that would significantly inhibit an organization’s ability to provide the critical services and functions deemed fundamental to their business mission. These disruptive events, defined as High Consequence Events (HCE), include both events that have occurred or could be realized through an attack of critical infrastructure owner assets. While other efforts have been initiated to identify and mitigate disruptive events at the national security level, such as Presidential Policy Directive 41 (PPD-41), this process is intended to be used by individual organizations to evaluate events that fall below the threshold for a national security. Described another way, Consequence Prioritization considers threats greater than those addressable by standard cyber-hygiene and includes the consideration of events that go beyond a traditional continuity of operations (COOP) perspective. Finally, Consequence Prioritization is most successful when organizations adopt a multi-disciplinary approach, engaging both cyber security and engineering expertise, as in-depth engineering perspectives are required to recognize and characterize and mitigate HCEs. Figure 1 provides a high-level overview of the prioritization process.

Jellyfish blooms in China: Dominant species, causes and consequences

International Nuclear Information System (INIS)

Dong Zhijun; Liu Dongyan; Keesing, John K.

2010-01-01

Three jellyfish species, Aurelia aurita, Cyanea nozakii and Nemopilema nomurai, form large blooms in Chinese seas. We report on the distribution and increasing incidence of jellyfish blooms and their consequences in Chinese coastal seas and analyze their relationship to anthropogenically derived changes to the environment in order to determine the possible causes. A. aurita, C. nozakii and N. nomurai form blooms in the temperate Chinese seas including the northern East China Sea, Yellow Sea and Bohai Sea. N. nomurai forms offshore blooms while the other two species bloom mainly in inshore areas. Eutrophication, overfishing, habitat modification for aquaculture and climate change are all possible contributory factors facilitating plausible mechanisms for the proliferation of jellyfish blooms. In the absence of improvement in coastal marine ecosystem health, jellyfish blooms could be sustained and may even spread from the locations in which they now occur.

Application of xenon difluoride for surface modification of polymers

International Nuclear Information System (INIS)

Barsamyan, G.B.; Belokonov, K.V.; Vargasova, N.A.; Sokolov, V.B.; Chaivanov, B.B.; Zubov, V.P.

1994-01-01

Chemical interaction between xenon difluoride (XeF 2 ) and polymeric materials was investigated. It was shown that the reaction occurs on the surface of solid polymer layer and brings to chemical modification of the surface properties of the polymer leaving the bulk properties unchanged. The results of various analysis of the fluorinated samples (IR, FTIR-ATR, ESCA, bulk analysis etc) are presented. The mechanism of reaction is proposed. 12 refs.; 13 figs

Value-impact assessment of safety-related modifications

International Nuclear Information System (INIS)

Knowles, W.M.C.; Dinnie, K.S.; Gordon, C.W.

1992-01-01

Like other nuclear utilities, Ontario Hydro, as part of its risk management activities, continually assesses the safety of its nuclear operations. In addition, new regulatory requirements are being applied to the older nuclear power plants. Both of these result in proposed plant modifications designed to reduce the risk to the public. However, modifications to an operating plant can have serious economic effects, and the resources, both financial and personnel, required for the implementation of these modifications are limited. Thus, all potential benefits and effects of a proposed modification must be thoroughly investigated to judge whether the modification is beneficial. Ontario Hydro has begun to use comprehensive value-impact assessments, utilizing plant-specific probabilistic risk assessments (PRAs), as tools to provide an informed basis for judgments on the benefit of safety-related modifications. The results from value-impact assessments can also be used to prioritize the implementation of these modifications

Characterization of Cell Wall Components and Their Modifications during Postharvest Storage of Asparagus officinalis L.: Storage-Related Changes in Dietary Fiber Composition.

Science.gov (United States)

Schäfer, Judith; Wagner, Steffen; Trierweiler, Bernhard; Bunzel, Mirko

2016-01-20

Changes in cell wall composition during storage of plant foods potentially alter the physiological effects of dietary fiber components. To investigate postharvest cell wall modifications of asparagus and their consequences in terms of insoluble dietary fiber structures, asparagus was stored at 20 and 1 °C for different periods of time. Structural analyses demonstrated postharvest changes in the polysaccharide profile, dominated by decreased portions of galactans. Increasing lignin contents correlated with compositional changes (monolignol ratios and linkage types) of the lignin polymer as demonstrated by chemical and two-dimensional nuclear magnetic resonance (2D-NMR) methods. Depending on the storage time and temperature, syringyl units were preferentially incorporated into the lignin polymer. Furthermore, a drastic increase in the level of ester-linked phenolic monomers (i.e., p-coumaric acid and ferulic acid) and polymer cross-links (di- and triferulic acids) was detected. The attachment of p-coumaric acid to lignin was demonstrated by 2D-NMR experiments. Potential consequences of postharvest modifications on physiological effects of asparagus dietary fiber are discussed.

Effect of nutrition education and diet modification in iron depleted preschool children in nurseries in Tehran: a pilot study.

Science.gov (United States)

Khoshnevisan, Farnaz; Kimiagar, Masood; Kalantaree, Nasser; Valaee, Nasser; Shaheedee, Nooshin

2004-07-01

In view of the high prevalence of iron deficiency in preschool children and its consequences, this study was carried out to examine the effect of nutrition education and dietary modification on 438 two- to six-year-old nursery school children in Tehran in 1999. Sixty-two children who were judged anemic, iron-depleted, or having low iron stores were randomly allocated to "control," "dietary modification" (consuming one additional citrus fruit after lunch), and "nutrition education" (teaching the mothers proper eating patterns based on the food pyramid) groups. Food habits were surveyed, including 24-hour dietary recall and food frequency, as well as timing of consumption of special items; this survey was carried out for each child before and after intervention. After three months, blood samples were taken from the subjects. The prevalence of anemia, iron depletion, and low iron stores was 11.4, 62.8, and 15.1% respectively, with no significant differences observed in hemoglobin and percent transferrin saturation (%TS) between the groups. Mean+/-SD serum ferritin concentrations in "control," "diet modification," and "nutrition education" groups were 8.9+/-3.1, 9.5+/-3.7, and 6.9+/-2.3 microg/dL. The same figures at the end of intervention were 6.9+/-3.5, 11.2+/-5, and 10.7+/-5.9 microg/dL, respectively. Analysis of variance showed ferritin concentrations to be significantly different, in that there was a reduction in the control and elevation in the nutrition education groups. There was no significant difference in %TS before and after the intervention. During three months of intervention, changes in frequency of fruit and fruit juice intake after the meals in nutrition education and diet modification groups were significantly correlated to serum ferritin alteration. Frequency of fruit juice intake (rich in vitamin C) after meals (at least five times a week) can significantly increase serum ferritin within three months. Therefore, educating mothers of iron

The Gouy-Stodola Theorem in Bioenergetic Analysis of Living Systems (Irreversibility in Bioenergetics of Living Systems

Directory of Open Access Journals (Sweden)

Umberto Lucia

2014-09-01

Full Text Available Thermodynamics studies the transformations of energy occurring in open systems. Living systems, with particular reference to cells, are complex systems in which energy transformations occur. Thermo-electro-chemical processes and transports occur across their border, the cells membranes. These processes take place with important differences between healthy and diseased states. In particular, different thermal and biochemical behaviours can be highlighted between these two states and they can be related to the energy transformations inside the living systems, in particular the metabolic behaviour. Moreover, living systems waste heat. This heat is the consequence of the internal irreversibility. Irreversibility is effectively studied by using the Gouy-Stodola theorem. Consequently, this approach can be introduced in the analysis of the states of living systems, in order to obtain a unifying approach to study them. Indeed, this approach allows us to consider living systems as black boxes and analyze only the inflows and outflows and their changes in relation to the modification of the environment, so information on the systems can be obtained by analyzing their behaviour in relation to the modification of external perturbations. This paper presents a review of the recent results obtained in the thermodynamics analysis of cell systems.

Probabilistic accident consequence uncertainty analysis: Food chain uncertainty assessment. Volume 1: Main report

Energy Technology Data Exchange (ETDEWEB)

Brown, J. [National Radiological Protection Board (United Kingdom); Goossens, L.H.J.; Kraan, B.C.P. [Delft Univ. of Technology (Netherlands)] [and others

1997-06-01

This volume is the first of a two-volume document that summarizes a joint project conducted by the US Nuclear Regulatory Commission and the European Commission to assess uncertainties in the MACCS and COSYMA probabilistic accident consequence codes. These codes were developed primarily for estimating the risks presented by nuclear reactors based on postulated frequencies and magnitudes of potential accidents. This document reports on an ongoing project to assess uncertainty in the MACCS and COSYMA calculations for the offsite consequences of radionuclide releases by hypothetical nuclear power plant accidents. A panel of sixteen experts was formed to compile credible and traceable uncertainty distributions for food chain variables that affect calculations of offsite consequences. The expert judgment elicitation procedure and its outcomes are described in these volumes. Other panels were formed to consider uncertainty in other aspects of the codes. Their results are described in companion reports. Volume 1 contains background information and a complete description of the joint consequence uncertainty study. Volume 2 contains appendices that include (1) a summary of the MACCS and COSYMA consequence codes, (2) the elicitation questionnaires and case structures for both panels, (3) the rationales and results for the panels on soil and plant transfer and animal transfer, (4) short biographies of the experts, and (5) the aggregated results of their responses.

Probabilistic accident consequence uncertainty analysis: Food chain uncertainty assessment. Volume 1: Main report

International Nuclear Information System (INIS)

Brown, J.; Goossens, L.H.J.; Kraan, B.C.P.

1997-06-01

This volume is the first of a two-volume document that summarizes a joint project conducted by the US Nuclear Regulatory Commission and the European Commission to assess uncertainties in the MACCS and COSYMA probabilistic accident consequence codes. These codes were developed primarily for estimating the risks presented by nuclear reactors based on postulated frequencies and magnitudes of potential accidents. This document reports on an ongoing project to assess uncertainty in the MACCS and COSYMA calculations for the offsite consequences of radionuclide releases by hypothetical nuclear power plant accidents. A panel of sixteen experts was formed to compile credible and traceable uncertainty distributions for food chain variables that affect calculations of offsite consequences. The expert judgment elicitation procedure and its outcomes are described in these volumes. Other panels were formed to consider uncertainty in other aspects of the codes. Their results are described in companion reports. Volume 1 contains background information and a complete description of the joint consequence uncertainty study. Volume 2 contains appendices that include (1) a summary of the MACCS and COSYMA consequence codes, (2) the elicitation questionnaires and case structures for both panels, (3) the rationales and results for the panels on soil and plant transfer and animal transfer, (4) short biographies of the experts, and (5) the aggregated results of their responses

Health consequences of nuclear accidents

International Nuclear Information System (INIS)

Masse, Roland

2011-10-01

The author first outlines that no exposure of mankind to environmental risks has been as exhaustively and continuously studied as that resulting from ionizing radiations. Apart from lethal effects, he describes non lethal cell lesions which are induced in tissues: mutations and modifications of gene expressions, either directly under the effect of radiation, or by water hydrolysis, or indirectly through a biochemical response to these initial events. Then, the author evokes the controversy about Chernobyl: according to scientists, there is no relationship between the health degradation (human morbidity and mortality) and fallouts whereas activist groups state that there is. The author then evokes that the WHO and the IAEA were accused to lie about the issue of victims and health consequences. He outlines that UNSCEAR reports are a reference for radio-biologists, and that the 2011 report confirmed the conclusions of the 2006 report. He comments some published data, notably those on the acute irradiation syndrome (ARS), on carcinogenic effects (essentially thyroid cancers for children, as there is no clear nor admitted relationship for other forms of cancer), on other pathologies. Finally, the author briefly discusses the issue of crisis management, the information about Fukushima, and the issue of Chernobyl fallouts in France

Surface-Modification of Carbonate Apatite Nanoparticles Enhances Delivery and Cytotoxicity of Gemcitabine and Anastrozole in Breast Cancer Cells

Directory of Open Access Journals (Sweden)

Fitya Syarifa Mozar

2017-06-01

Full Text Available pH sensitive nanoparticles of carbonate apatite (CA have been proven to be effective delivery vehicles for DNA, siRNAs and proteins. More recently, conventional anti-cancer drugs, such as doxorubicin, methotrexate and cyclophosphamide have been successfully incorporated into CA for intracellular delivery to breast cancer cells. However, physical and chemical properties of drug molecules appeared to affect their interactions with CA, with hydrophillic drug so far exhibiting better binding affinity and cellular uptakes compared to hydrophobic drugs. In this study, anastrozole, a non-steroidal aromatase inhibitor which is largely hydrophobic, and gemcitabine, a hydrophilic nucleoside inhibitor were used as solubility models of chemotherapy drug. Aggregation tendency of poorly soluble drugs resulting in larger particle-drug complex size might be the main factor hindering their delivery effectiveness. For the first time, surface modification of CA with poly(ethylene glycol (PEG has shown promising result to drastically reduce anastrozole- loaded CA particle size, from approximately 1000 to 500 nm based on zeta sizer analysis. Besides PEG, a cell specific ligand, in this case fibronectin, was attached to the particles in order to facilitate receptor mediated endocytosis based on fibronectin–integrin interaction. High-performance liquid chromatography (HPLC was performed to measure uptake of the drugs by breast cancer cells, revealing that surface modification increased the drug uptake, especially for the hydrophobic drug, compared to the uncoated particles and the free drug. In vitro chemosensitivity assay and in vivo tumor regression study also showed that coated apatite/drug nanoparticle complexes presented higher cytotoxicity and tumor regression effects than uncoated apatite/drug nanoparticles and free drugs, indicating that surface modification successfully created optimum particles size with the consequence of more effective uptake along with

Thoracoabdominal computed tomography in trauma patients: a cost-consequences analysis

NARCIS (Netherlands)

Vugt, R. van; Kool, D.R.; Brink, M.; Dekker, H.M.; Deunk, J.; Edwards, M.J.R.

2014-01-01

BACKGROUND: CT is increasingly used during the initial evaluation of blunt trauma patients. In this era of increasing cost-awareness, the pros and cons of CT have to be assessed. OBJECTIVES: This study was performed to evaluate cost-consequences of different diagnostic algorithms that use

Modification of Sr on 4004 Aluminum Alloy

Science.gov (United States)

Guo, Erjun; Cao, Guojian; Feng, Yicheng; Wang, Liping; Wang, Guojun; Lv, Xinyu

2013-05-01

As a brazing foil, 4004 Al alloy has good welding performance. However, the high Si content decreases the plasticity of the alloy. To improve the plasticity of 4004 Al alloy and subsequently improve the productivity of 4004 Al foil or 434 composite foil, 4004 Al alloy was modified by Al-10%Sr master alloy. Modification effects of an additional amount of Sr, modification temperature, and holding time on 4004 aluminum alloy were studied by orthogonal design. The results showed that the greatest impact parameter of 4004 aluminum alloy modification was the additional amount of Sr, followed by holding time and modification temperature. The optimum modification parameters obtained by orthogonal design were as follows: Sr addition of 0.04%, holding time of 60 min, and modification temperature of 760°C. The effect of Sr addition on modification was analyzed in detail based on orthogonal results. With increasing of Sr addition, elongation of 4004 alloy increased at first, and decreased after reaching the maximum value.

Chemical Modifications of Starch: Microwave Effect

Directory of Open Access Journals (Sweden)

Kamila Lewicka

2015-01-01

Full Text Available This paper presents basic methods of starch chemical modification, the effect of microwave radiation on the modification process, and the physicochemical properties of starch. It has been shown that the modifications contribute to improvement of the material performance and likewise to significant improvement of its mechanical properties. As a result, more and more extensive use of starch is possible in various industries. In addition, methods of oxidized starch and starch esters preparation are discussed. Properties of microwave radiation and its impact on starch (with particular regard to modifications described in literature are characterized.

Modification Semantics in Now-Relative Databases

DEFF Research Database (Denmark)

Torp, Kristian; Jensen, Christian Søndergaard; Snodgrass, R. T.

2004-01-01

Most real-world databases record time-varying information. In such databases, the notion of ??the current time,?? or NOW, occurs naturally and prominently. For example, when capturing the past states of a relation using begin and end time columns, tuples that are part of the current state have some...... past time as their begin time and NOW as their end time. While the semantics of such variable databases has been described in detail and is well understood, the modification of variable databases remains unexplored. This paper defines the semantics of modifications involving the variable NOW. More...... specifically,  the problems with modifications in the presence of NOW are explored, illustrating that the main problems are with modifications of tuples that reach into the future. The paper defines the semantics of modifications?including insertions, deletions, and updates?of databases without NOW, with NOW...

The SocioEconomic Analysis of Repository Siting (SEARS): Supplement to the SEARS technical documentation for the SEARS modifications

International Nuclear Information System (INIS)

Parpia, B.; Fannin, D.; Murdock, S.; Hamm, R.; Ransom-Nelson, W.; Leistritz, F.L.

1985-09-01

This supplement follows a format similar to that used in the SEARS Technical Documentation. Chapter 1 consists of a brief description of each of the modifications and then describes the alterations and additions to the relevant model components, subroutines and/or data files. Chapter 2 provides a partial model run showing the user- alterable procedures involved in the implementation of each of these modifications, and chapter 3 contains the schematic flowcharts and supplemental listings of the APL computer code altered as a result of these modifications. This report is part of the overall model documentation. 5 figs

Development of Cognitive Bias Modification (CBM) Tools to Promote Adjustment during Reintegration following Deployment

Science.gov (United States)

2017-06-01

a meta-analysis. Child development 73 (3), 916-934. Owen, J.M., 2011. Transdiagnostic cognitive processes in high trait anger. Clinical Psychology ...Award Number: W81XWH-13-2-0001 TITLE: : Development of Cognitive Bias Modification (CBM) Tools to Promote Adjustment during Reintegration...DATES COVERED 15-OCT-2012 TO 14-OCT-2016 4. TITLE AND SUBTITLE Development of Cognitive Bias Modification (CBM) Tools to Promote Adjustment during

Structured self monitoring of blood glucose in Iranian people with type 2 diabetes; A cost consequence analysis

Directory of Open Access Journals (Sweden)

Aghili Rokhsareh

2012-09-01

Full Text Available Abstract Background Self-Monitoring of Blood Glucose (SMBG is considered as a key factor in management of people with diabetes which is a growing and cost demanding health problem. The purpose of this study was to investigate the effect of comprehensive patient management using structured SMBG on metabolic control as well as its cost consequence analysis. Methods Sixty subjects were recruited in an observational study for a period of 6 months. They were provided with the ACCU-CHEK 360° View tool to fill in the values of the 7-point blood glucose profiles in three consecutive days during the study on a monthly basis. Changes in metabolic control were assessed by HbA1c and lipid profile measurement at the beginning and at the end of the study. In addition, cost consequence analysis was done considering different level of health care professionals with or without insurance coverage. The Average Cost Effectiveness Ratio (ACER as well as Cost saving analysis were calculated and compared. Results The analysis showed significant reduction in HbA1c during the 6-month period in all subjects (P = 0.000. Furthermore, a positive effect was observed on lipid profile. The cost of endocrinologist’s visit in private sector was estimated to be 265.76 USD while this figure was149.15 USD for general practitioner in public sector with insurance coverage. Total complications and mortality cost saving was 154.8 USD. The lowest ACER was calculated for intervention with general practitioner in public sector with insurance coverage. Conclusion Structured SMBG results in significant improvement of glycemic status. Moreover, it is more cost saving in public sector with insurance coverage. It seems that general practitioner visits with insurance coverage is the most affordable option for people with type 2 diabetes.

Determinants of Health Information Use for Self-Efficacy in Lifestyle Modification for Chronic Disease Patients

Directory of Open Access Journals (Sweden)

Ebele N. Anyaoku

2016-04-01

Full Text Available Objectives – Various efforts are being made to disseminate lifestyle modification information. What is the role of health information in building patients self-efficacy in lifestyle modification? The research examined level of access to lifestyle modification information for patients with chronic diseases in two Federal Government Teaching Hospitals in South East Nigeria. It explored the relationship between self-efficacy and access to lifestyle modification information and also factors that are associated with self-efficacy when patients have access to lifestyle modification information. Methods – The research is a cross-sectional correlation study that used a questionnaire to collect data. (See Appendix A. Sample was 784 patients with chronic diseases. Questionnaires were distributed to the patients as they attended clinics in the medical and surgical outpatients’ clinics of the hospitals. Results – Findings showed access to lifestyle modification information was significantly and positively correlated with self-efficacy. Multiple Regression analysis suggest that age, type of illness, and length of treatment in the teaching hospitals were associated with self-efficacy when patients have access to lifestyle modification information. Conclusion – It will be pertinent that demographic and disease factors are considered when making lifestyle modification information available to patients for greater self-efficacy.

Design assurance programme for modifications at the Ringhals Nuclear Power Plant

International Nuclear Information System (INIS)

Persson, K.

1985-01-01

The Engineering Department within the site organization is responsible for modifications and improvements of plant design. Internal and external specialists are also involved in the design activities. Modifications follow the procedures laid down in the Design Assurance Programme (DAP), according to the overall directions given in 10CFR50 APP B and the more detailed recommendations in American Nuclear Standard 3.2, and the United States Nuclear Regulatory Commission's Regulatory Guides 1.33 and 1.64. The site Quality Assurance Department has adapted these directions to Swedish conditions. All plant modifications are ordered from customers within the site organization. The design work is performed according to the following steps: priority of problems or requirements; overall analysis of problems or requirements; basic design (preliminary and final); detailed design (electrical, mechanical, civil); purchase of equipment; installation in plant; testing of installed equipment. The project engineer is responsible for modifications from the initiation of analysis until testing and documentation are finalized. For each step, procedures and checklists are available. Internal and external specialists as well as the Swedish Nuclear Inspectorate are involved when appropriate. Design engineers and QC/QE engineers are also involved. Special groups within the site organization handle purchase and installation. Testing the installed equipment is performed in co-operation with the operation staff. Deviations from DAP must be reported by all personnel, and corrective actions must be taken. Internal audits have to be done once a year for the entire DAP and the audit, with its findings and the corrective actions taken, must be reported to the QA group. (author)

Structure modification of Mg-Nb films under hydrogen sorption cycles

Energy Technology Data Exchange (ETDEWEB)

Mengucci, P., E-mail: p.mengucci@univpm.it [Dipartimento di Fisica e Ingegneria dei Materiali e del Territorio, Universita Politecnica delle Marche, Via Brecce Bianche, I-60131 Ancona (Italy); Barucca, G.; Majni, G. [Dipartimento di Fisica e Ingegneria dei Materiali e del Territorio, Universita Politecnica delle Marche, Via Brecce Bianche, I-60131 Ancona (Italy); Bazzanella, N.; Checchetto, R.; Miotello, A. [Dipartimento di Fisica, Universita di Trento, Via Sommarive, I-38123 Povo (Italy)

2011-09-15

Research highlights: > Influence of Nb additions on the hydrogen kinetics of Mg layers. > Structure modification of the Mg matrix during hydrogen cycling. > Lattice strains induced by Nb tends to decrease during hydrogen cycling. > Nb nanoparticles form during hydrogen cycling. > Nb enhances the porous structure of the Mg layer formed during hydrogen cycling. - Abstract: In the present work we focus our attention on the structural modifications induced by repeated absorption/desorption cycles on Mg-Nb layers. Samples consisting of a 30 {mu}m thick pure Mg or Mg-5 at.% Nb doped films, coated with a 20 nm thick Pd layer were submitted to repeated H{sub 2} sorption cycles in a volumetric apparatus. Isothermal desorption analysis at 350 deg. C was performed to evaluate the amount of absorbed hydrogen. X-ray diffraction (XRD), energy dispersive spectroscopy (EDS) and electron microscopy techniques (SEM and TEM) were used for the structural characterisation of the samples. Analyses show a deep modification of the material upon cycling. The presence of Nb enhances the structural modifications and induces an initial lattice contraction of the Mg matrix that tends to decrease on cycling via the formation of Nb nanoparticles (with average size of {approx}10 nm). SEM and TEM observations performed in cross section evidenced the formation of a porous structure.

Dynamical tendencies of health consequences caused by competitive risk factors

International Nuclear Information System (INIS)

Bykov, A.A.; Pronina, I.A.; Kudriavtsev, G.I.

2000-01-01

The paper deals with the generalized probabilistic approach for analyzing health consequences caused by various exposure factors. Formally basing on the competitive risk theory, it is introduced a general risk model for analysis the influence of environmental risk factors to human health. The usefulness of the model approach is in the opportunity of taking into account: time delay of impact and consequence manifestation; easy comparisons of exposure factors with different nature and various consequences (morbidity and mortality, carcinogenic and genetic); social and environmental components in overall mortality. Preliminary examples of comparative risk analysis are demonstrated on the Russian demography and environmental data with the attempt of characterizing the dynamical tendencies and evolution of introduced risk index. The prospects of the probabilistic approach and the results obtaining on this basis are discussed. (author)

An Analysis of the Causes and Consequences of Kidnapping in ...

African Journals Online (AJOL)

Thus, the objectives of the study are: to examine the nexus between terrorism and kidnapping; to investigate the mutual reinforcement between corruption and kidnapping; to find out if kidnapping and poverty are correlated; and to examine the consequences of the problem. Using secondary qualitative data, the study found ...

Attitudes Toward Genetic Modification Research: An Analysis of the Views of the Sputnik Generation.

Science.gov (United States)

Miller, Jon D.

1982-01-01

Utilizing data from the 1977 National Assessment of Educational Progress (NAEP) survey of young adults, summarizes attitudes toward genetic modification research and the demographic, educational, and occupational correlates of these attitudes. (Author/SK)

RCRA permit modifications and the functional equivalency demonstration: A case study

International Nuclear Information System (INIS)

Kinker, J.; Lyon, W.; Carnes, R.; Loehr, C.; Elsberry, K.; Garcia, P.

1996-01-01

Hazardous waste operating permits issued under the Resource Conservation and Recovery Act (RCRA) often impose requirements, typically by reference to the original permit application, that specific components and equipment be used. Consequently, changing these items, even for the purpose of routine maintenance, may first require that the owner/operator request a potentially time-consuming and costly permit modification. However, the owner/operator may demonstrate that a modification is not required because the planned changes are functionally equivalent, as defined by RCRA, to the original specifications embodied by the permit. The Controlled-Air Incinerator at Los Alamos National Laboratory is scheduled for maintenance and improvements that involve replacement of components. The incinerator's carbon adsorption unit/high efficiency particulate air filtration system, in particular, was redesigned to improve reliability and minimize maintenance. A study was performed to determine whether the redesigned unit would qualify as functionally equivalent to the original component. in performing this study, the following steps were taken: (a) the key performance factors were identified; (b) performance data describing the existing unit were obtained; (c) performance of both the existing and redesigned units was simulated; and (d) the performance data were compared to ascertain whether the components could qualify as functionally equivalent

Uncertainty and sensitivity analysis of chronic exposure results with the MACCS reactor accident consequence model

International Nuclear Information System (INIS)

Helton, J.C; Johnson, J.D; Rollstin, J.A; Shiver, A.W; Sprung, J.L

1995-01-01

Uncertainty and sensitivity analysis techniques based on Latin hypercube sampling, partial correlation analysis and stepwise regression analysis are used in an investigation with the MACCS model of the chronic exposure pathways associated with a severe accident at a nuclear power station. The primary purpose of this study is to provide guidance on the variables to be considered in future review work to reduce the uncertainty in the important variables used in the calculation of reactor accident consequences. The effects of 75 imprecisely known input variables on the following reactor accident consequences are studied: crop growing-season dose, crop long-term dose, water ingestion dose, milk growing-season dose, long-term groundshine dose, long-term inhalation dose, total food pathways dose, total ingestion pathways dose, total long-term pathways dose, total latent cancer fatalities, area-dependent cost, crop disposal cost, milk disposal cost, population-dependent cost, total economic cost, condemnation area, condemnation population, crop disposal area and milk disposal area. When the predicted variables are considered collectively, the following input variables were found to be the dominant contributors to uncertainty: dry deposition velocity, transfer of cesium from animal feed to milk, transfer of cesium from animal feed to meet, ground concentration of Cs-134 at which the disposal of milk products will be initiated, transfer of Sr-90 from soil to legumes, maximum allowable ground concentration of Sr-90 for production of crops, fraction of cesium entering surface water that is consumed in drinking water, groundshine shielding factor, scale factor defining resuspension, dose reduction associated with decontamination, and ground concentration of I-131 at which disposal of crops will be initiated due to accidents that occur during the growing season. Reducing the uncertainty in the preceding variables was found to substantially reduce the uncertainty in the

An Examination of the Relationship between Consequence-Specific Normative Belief Patterns and Alcohol-Related Consequences among College Students

Science.gov (United States)

Reavy, Racheal; Cleveland, Michael J.; Mallett, Kimberly A.; Scaglione, Nichole M.; Sell, Nichole M.; Turrisi, Rob

2016-01-01

Background Research has previously identified a high-risk subgroup of college students who experience high levels of multiple and repeated alcohol-related consequences (MRC group). The purpose of this study was to examine the association between consequence-specific normative influences and experiencing multiple and repeated drinking-related consequences using a person-centered approach. Normative subgroups were identified using latent profile analysis (LPA), which were then used to predict MRC group status at 6-month follow-up. Methods First-year college student drinkers (N=2024) at a large northeastern university completed online surveys during the fall and spring semesters of their freshman year. Retention was high with 92% of invited participants completing T2, of which the MRC group accounted for 27%. Results Three student profiles were identified from LPA on T1 data: Non Permissive Parents (77%), Positive Peer and Parent Norms (20%), and Permissive Parents (3%). Logistic regression revealed that both the Positive Peer and Parent Norms and Permissive Parents profiles had significantly higher odds of MRC group membership at follow-up (1.81 and 2.78 times greater, respectively). Conclusions The results suggest value in prevention efforts that include normative beliefs about alcohol-related consequences. Further, parental norms in particular have the potential to enhance interventions, especially through direct communication of disapproval for experiencing consequences. PMID:27805274

Specialized rheumatology nurse substitutes for rheumatologists in the diagnostic process of fibromyalgia: a cost-consequence analysis and a randomized controlled trial

NARCIS (Netherlands)

Kroese, Mariëlle E.; Severens, Johan L.; Schulpen, Guy J.; Bessems, Monique C.; Nijhuis, Frans J.; Landewé, Robert B.

2011-01-01

To perform a cost-consequence analysis of the substitution of specialized rheumatology nurses (SRN) for rheumatologists (RMT) in the diagnostic process of fibromyalgia (FM), using both a healthcare and societal perspective and a 9-month period. Alongside a randomized controlled trial, we measured

Site specific modification of the human plasma proteome by methylglyoxal

International Nuclear Information System (INIS)

Kimzey, Michael J.; Kinsky, Owen R.; Yassine, Hussein N.; Tsaprailis, George; Stump, Craig S.; Monks, Terrence J.; Lau, Serrine S.

2015-01-01

Increasing evidence identifies dicarbonyl stress from reactive glucose metabolites, such as methylglyoxal (MG), as a major pathogenic link between hyperglycemia and complications of diabetes. MG covalently modifies arginine residues, yet the site specificity of this modification has not been thoroughly investigated. Sites of MG adduction in the plasma proteome were identified using LC–MS/MS analysis in vitro following incubation of plasma proteins with MG. Treatment of plasma proteins with MG yielded 14 putative MG hotspots from five plasma proteins (albumin [nine hotspots], serotransferrin, haptoglobin [2 hotspots], hemopexin, and Ig lambda-2 chain C regions). The search results revealed two versions of MG-arginine modification, dihydroxyimidazolidine (R + 72) and hydroimidazolone (R + 54) adducts. One of the sites identified was R257 in human serum albumin, which is a critical residue located in drug binding site I. This site was validated as a target for MG modification by a fluorescent probe displacement assay, which revealed significant drug dissociation at 300 μM MG from a prodan–HSA complex (75 μM). Moreover, twelve human plasma samples (six male, six female, with two type 2 diabetic subjects from both genders) were analyzed using multiple reaction monitoring (MRM) tandem mass spectrometry and revealed the presence of the MG-modified albumin R257 peptide. These data provide insights into the nature of the site-specificity of MG modification of arginine, which may be useful for therapeutic treatments that aim to prevent MG-mediated adverse responses in patients. - Highlights: • Methylglyoxal (MG) selectively modifies arginine sites in human plasma proteome. • Dihydroxyimidazolidine and hydroimidazolone adducts on serum albumin identified • MG modification on albumin R257 associated with loss of drug site I binding capacity • MRM-tandem mass spectrometry enables sensitive detection of albumin MG-R257. • Site-specific MG modification may

Site specific modification of the human plasma proteome by methylglyoxal

Energy Technology Data Exchange (ETDEWEB)

Kimzey, Michael J.; Kinsky, Owen R. [Southwest Environmental Health Sciences Center, Department of Pharmacology & Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ 85721 (United States); Yassine, Hussein N. [Department of Medicine, The University of Arizona, Tucson, AZ 85721 (United States); Tsaprailis, George [Southwest Environmental Health Sciences Center, Department of Pharmacology & Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ 85721 (United States); Stump, Craig S. [Department of Medicine, The University of Arizona, Tucson, AZ 85721 (United States); Southern Arizona VA Health Care System, Tucson, AZ 85723 (United States); Monks, Terrence J. [Southwest Environmental Health Sciences Center, Department of Pharmacology & Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ 85721 (United States); Lau, Serrine S., E-mail: lau@pharmacy.arizona.edu [Southwest Environmental Health Sciences Center, Department of Pharmacology & Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ 85721 (United States)

2015-12-01

Increasing evidence identifies dicarbonyl stress from reactive glucose metabolites, such as methylglyoxal (MG), as a major pathogenic link between hyperglycemia and complications of diabetes. MG covalently modifies arginine residues, yet the site specificity of this modification has not been thoroughly investigated. Sites of MG adduction in the plasma proteome were identified using LC–MS/MS analysis in vitro following incubation of plasma proteins with MG. Treatment of plasma proteins with MG yielded 14 putative MG hotspots from five plasma proteins (albumin [nine hotspots], serotransferrin, haptoglobin [2 hotspots], hemopexin, and Ig lambda-2 chain C regions). The search results revealed two versions of MG-arginine modification, dihydroxyimidazolidine (R + 72) and hydroimidazolone (R + 54) adducts. One of the sites identified was R257 in human serum albumin, which is a critical residue located in drug binding site I. This site was validated as a target for MG modification by a fluorescent probe displacement assay, which revealed significant drug dissociation at 300 μM MG from a prodan–HSA complex (75 μM). Moreover, twelve human plasma samples (six male, six female, with two type 2 diabetic subjects from both genders) were analyzed using multiple reaction monitoring (MRM) tandem mass spectrometry and revealed the presence of the MG-modified albumin R257 peptide. These data provide insights into the nature of the site-specificity of MG modification of arginine, which may be useful for therapeutic treatments that aim to prevent MG-mediated adverse responses in patients. - Highlights: • Methylglyoxal (MG) selectively modifies arginine sites in human plasma proteome. • Dihydroxyimidazolidine and hydroimidazolone adducts on serum albumin identified • MG modification on albumin R257 associated with loss of drug site I binding capacity • MRM-tandem mass spectrometry enables sensitive detection of albumin MG-R257. • Site-specific MG modification may

Modification of GNPS environment radiation monitoring network system

International Nuclear Information System (INIS)

Jiang Lili; Cao Chunsheng

1999-01-01

GNPS Environment Radiation Continuous Monitoring System (KRS), the only real time on-line system of site radiation monitoring, was put into service in 1993 prior to the first loading the the plant. It is revealed through several years of operation that this system has some deficiencies such as inadequate real time monitoring means, no figure and diagram display function on the central computer, high failures, frequent failure warning signals, thus making the availability of the system at a low level. In recent years, with the rapid development of computer network technology and increasingly strict requirements on the NPP environment protection raised by the government and public, KRS modification had become necessary and urgent. In 1996, GNPS carried out modification work on the measuring geometry condition of γ radiation monitoring sub-station and lightening protection. To enhance the functions of real time monitoring and data auto-processing, further modification of the system was made in 1998, including the update of the software and hardware of KRS central processor, set-up of system computer local network and database. In this way, the system availability and monitoring quality are greatly improved and effective monitoring and analysis means are provided for gaseous release during normal operation and under accident condition

Epigenetic Modifications and Diabetic Retinopathy

Directory of Open Access Journals (Sweden)

Renu A. Kowluru

2013-01-01

Full Text Available Diabetic retinopathy remains one of the most debilitating chronic complications, but despite extensive research in the field, the exact mechanism(s responsible for how retina is damaged in diabetes remains ambiguous. Many metabolic pathways have been implicated in its development, and genes associated with these pathways are altered. Diabetic environment also facilitates epigenetics modifications, which can alter the gene expression without permanent changes in DNA sequence. The role of epigenetics in diabetic retinopathy is now an emerging area, and recent work has shown that genes encoding mitochondrial superoxide dismutase (Sod2 and matrix metalloproteinase-9 (MMP-9 are epigenetically modified, activates of epigenetic modification enzymes, histone lysine demethylase 1 (LSD1, and DNA methyltransferase are increased, and the micro RNAs responsible for regulating nuclear transcriptional factor and VEGF are upregulated. With the growing evidence of epigenetic modifications in diabetic retinopathy, better understanding of these modifications has potential to identify novel targets to inhibit this devastating disease. Fortunately, the inhibitors and mimics targeted towards histone modification, DNA methylation, and miRNAs are now being tried for cancer and other chronic diseases, and better understanding of the role of epigenetics in diabetic retinopathy will open the door for their possible use in combating this blinding disease.

A Development of Domestic Food Chain Model Data for Chronic Effect Estimation of Off-site Consequence Analysis

Energy Technology Data Exchange (ETDEWEB)

Han, Seok-Jung; KEUM, Dong-Kwon; Jang, Seung-Cheol [KAERI, Daejeon (Korea, Republic of)

2015-05-15

The FCM includes complex transport phenomena of radiation materials on a biokinetic system of contaminated environments. An estimation of chronic health effects is a key part of the level 3 PSA (Probabilistic Safety Assessment), which depends on the FCM estimation from contaminated foods ingestion. A cultural ingestion habit of a local region and agricultural productions are different to the general features over worldwide scale or case by case. This is a reason to develop a domestic FCM data for the level 3 PSA. However, a generation of the specific FCM data is a complex process and under a large degree of uncertainty due to inherent biokinetic models. As a preliminary study, the present study focuses on an infrastructure development to generation of a specific FCM data. During this process, the features of FCM data to generate a domestic FCM data were investigated. Based on the insights obtained from this process, a specific domestic FCM data was developed. The present study was developed a domestic FCM data to estimate the chronic health effects of off-site consequence analysis. From this study, an insight was obtained, that a domestic FCM data is roughly 20 times higher than the MACCS2 defaults data. Based on this observation, it is clear that the specific chronic health effects of a domestic plant site should be considered in the off-site consequence analysis.

A Development of Domestic Food Chain Model Data for Chronic Effect Estimation of Off-site Consequence Analysis

International Nuclear Information System (INIS)

Han, Seok-Jung; KEUM, Dong-Kwon; Jang, Seung-Cheol

2015-01-01

The FCM includes complex transport phenomena of radiation materials on a biokinetic system of contaminated environments. An estimation of chronic health effects is a key part of the level 3 PSA (Probabilistic Safety Assessment), which depends on the FCM estimation from contaminated foods ingestion. A cultural ingestion habit of a local region and agricultural productions are different to the general features over worldwide scale or case by case. This is a reason to develop a domestic FCM data for the level 3 PSA. However, a generation of the specific FCM data is a complex process and under a large degree of uncertainty due to inherent biokinetic models. As a preliminary study, the present study focuses on an infrastructure development to generation of a specific FCM data. During this process, the features of FCM data to generate a domestic FCM data were investigated. Based on the insights obtained from this process, a specific domestic FCM data was developed. The present study was developed a domestic FCM data to estimate the chronic health effects of off-site consequence analysis. From this study, an insight was obtained, that a domestic FCM data is roughly 20 times higher than the MACCS2 defaults data. Based on this observation, it is clear that the specific chronic health effects of a domestic plant site should be considered in the off-site consequence analysis

A new green methodology for surface modification of diatomite filler in elastomers

Energy Technology Data Exchange (ETDEWEB)

Lamastra, F.R. [Italian Interuniversity Consortium on Materials Science and Technology (INSTM), Research Unit Roma Tor Vergata, Via del Politecnico 1, 00133, Rome (Italy); Mori, S.; Cherubini, V. [Italian Interuniversity Consortium on Materials Science and Technology (INSTM), Research Unit Roma Tor Vergata, Via del Politecnico 1, 00133, Rome (Italy); Department of Enterprise Engineering, University of Rome ' Tor Vergata' , Via del Politecnico 1, 00133, Rome (Italy); Scarselli, M. [Department of Physics, University of Rome ' Tor Vergata' , Via della Ricerca Scientifica 1, 00133, Rome (Italy); Nanni, F., E-mail: fnanni@ing.uniroma2.it [Italian Interuniversity Consortium on Materials Science and Technology (INSTM), Research Unit Roma Tor Vergata, Via del Politecnico 1, 00133, Rome (Italy); Department of Enterprise Engineering, University of Rome ' Tor Vergata' , Via del Politecnico 1, 00133, Rome (Italy)

2017-06-15

In this work a new, simple and green protocol to introduce a limited content of silanol groups on the surface of an hydrophobic diatomite, in order to be slightly hydrophilic and susceptible to be silanized by bifunctional, sulfur-containing organosilanes for rubber applications, is proposed. The chemical modification was carried out at 85 °C in a solution of H{sub 2}O:NaOH:H{sub 2}O{sub 2}. The modified diatomite was then silanized with bis(triethoxysilylpropyl) disulfide by a procedure that does not involve toxic solvent. Morphological features and elemental composition of diatomite were investigated by Field emission scanning electron microscopy coupled with Energy dispersive X-ray spectroscopy. The surface modification and silanization process were assessed by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. Diatomite was composed by micrometric frustules from different diatom species with pore size ranging from 25 nm to 1 μm. The spectroscopic characterizations confirmed the surface modification of diatomite with some silanols that acted as sites for silanization reaction. The silanized diatomite and the untreated one were used as filler in unvulcanized solvent-cast SBR films in order to verify that the modification does not negatively affect the polymer/filler interface and as consequence the mechanical properties. Mechanical properties of the realized samples were assessed by uniaxial tensile tests. Films filled with 10 wt% of diatomite (untreated or silanized) showed an increase of Elastic Modulus about of 50% and a decrease of the strain at break with respect to SBR samples, while the tensile strength was not significantly affected by the diatomite addition. SEM images of fracture surfaces of tested specimens showed a fine dispersion of both untreated and silanized diatomite in the polymeric matrix and the achieving of a good interfacial adhesion SBR/fillers. The silanized diatomite, as it is potentially able to bind

A new green methodology for surface modification of diatomite filler in elastomers

International Nuclear Information System (INIS)

Lamastra, F.R.; Mori, S.; Cherubini, V.; Scarselli, M.; Nanni, F.

2017-01-01

In this work a new, simple and green protocol to introduce a limited content of silanol groups on the surface of an hydrophobic diatomite, in order to be slightly hydrophilic and susceptible to be silanized by bifunctional, sulfur-containing organosilanes for rubber applications, is proposed. The chemical modification was carried out at 85 °C in a solution of H_2O:NaOH:H_2O_2. The modified diatomite was then silanized with bis(triethoxysilylpropyl) disulfide by a procedure that does not involve toxic solvent. Morphological features and elemental composition of diatomite were investigated by Field emission scanning electron microscopy coupled with Energy dispersive X-ray spectroscopy. The surface modification and silanization process were assessed by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. Diatomite was composed by micrometric frustules from different diatom species with pore size ranging from 25 nm to 1 μm. The spectroscopic characterizations confirmed the surface modification of diatomite with some silanols that acted as sites for silanization reaction. The silanized diatomite and the untreated one were used as filler in unvulcanized solvent-cast SBR films in order to verify that the modification does not negatively affect the polymer/filler interface and as consequence the mechanical properties. Mechanical properties of the realized samples were assessed by uniaxial tensile tests. Films filled with 10 wt% of diatomite (untreated or silanized) showed an increase of Elastic Modulus about of 50% and a decrease of the strain at break with respect to SBR samples, while the tensile strength was not significantly affected by the diatomite addition. SEM images of fracture surfaces of tested specimens showed a fine dispersion of both untreated and silanized diatomite in the polymeric matrix and the achieving of a good interfacial adhesion SBR/fillers. The silanized diatomite, as it is potentially able to bind chemically to

RNomics and Modomics in the halophilic archaea Haloferax volcanii: identification of RNA modification genes

Directory of Open Access Journals (Sweden)

Decatur Wayne A

2008-10-01

Full Text Available Abstract Background Naturally occurring RNAs contain numerous enzymatically altered nucleosides. Differences in RNA populations (RNomics and pattern of RNA modifications (Modomics depends on the organism analyzed and are two of the criteria that distinguish the three kingdoms of life. If the genomic sequences of the RNA molecules can be derived from whole genome sequence information, the modification profile cannot and requires or direct sequencing of the RNAs or predictive methods base on the presence or absence of the modifications genes. Results By employing a comparative genomics approach, we predicted almost all of the genes coding for the t+rRNA modification enzymes in the mesophilic moderate halophile Haloferax volcanii. These encode both guide RNAs and enzymes. Some are orthologous to previously identified genes in Archaea, Bacteria or in Saccharomyces cerevisiae, but several are original predictions. Conclusion The number of modifications in t+rRNAs in the halophilic archaeon is surprisingly low when compared with other Archaea or Bacteria, particularly the hyperthermophilic organisms. This may result from the specific lifestyle of halophiles that require high intracellular salt concentration for survival. This salt content could allow RNA to maintain its functional structural integrity with fewer modifications. We predict that the few modifications present must be particularly important for decoding, accuracy of translation or are modifications that cannot be functionally replaced by the electrostatic interactions provided by the surrounding salt-ions. This analysis also guides future experimental validation work aiming to complete the understanding of the function of RNA modifications in Archaeal translation.

Maximum type 1 error rate inflation in multiarmed clinical trials with adaptive interim sample size modifications.

Science.gov (United States)

Graf, Alexandra C; Bauer, Peter; Glimm, Ekkehard; Koenig, Franz

2014-07-01

Sample size modifications in the interim analyses of an adaptive design can inflate the type 1 error rate, if test statistics and critical boundaries are used in the final analysis as if no modification had been made. While this is already true for designs with an overall change of the sample size in a balanced treatment-control comparison, the inflation can be much larger if in addition a modification of allocation ratios is allowed as well. In this paper, we investigate adaptive designs with several treatment arms compared to a single common control group. Regarding modifications, we consider treatment arm selection as well as modifications of overall sample size and allocation ratios. The inflation is quantified for two approaches: a naive procedure that ignores not only all modifications, but also the multiplicity issue arising from the many-to-one comparison, and a Dunnett procedure that ignores modifications, but adjusts for the initially started multiple treatments. The maximum inflation of the type 1 error rate for such types of design can be calculated by searching for the "worst case" scenarios, that are sample size adaptation rules in the interim analysis that lead to the largest conditional type 1 error rate in any point of the sample space. To show the most extreme inflation, we initially assume unconstrained second stage sample size modifications leading to a large inflation of the type 1 error rate. Furthermore, we investigate the inflation when putting constraints on the second stage sample sizes. It turns out that, for example fixing the sample size of the control group, leads to designs controlling the type 1 error rate. © 2014 The Author. Biometrical Journal published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

The Iran nuclear ambitions and the international consequences; Les ambitions nucleaires de l'Iran et leurs consequences internationales

Energy Technology Data Exchange (ETDEWEB)

NONE

2005-01-15

This analysis of the Iran situation concerning the nuclear policy, is presented and discussed in three parts: the data and hypothesis of the iranian nuclear program, the regional strategy of Iran and evolution scenario and their consequences. (A.L.B.)

Diagnostic Invasiveness and Psychosocial Consequences of False-Positive Mammography

DEFF Research Database (Denmark)

Heleno, Bruno M.; Siersma, Volkert Dirk; Brodersen, John

2015-01-01

PURPOSE: We undertook a study to assess whether women with false-positivemammography have worse psychosocial consequences if managed with aworkup that involves a biopsy (invasive group) than if managed with only additional imaging (noninvasive group). METHODS: We performed subgroup analysis...... of a cohort study of 454 womenwith abnormal screening mammography and 908 matched control women withnormal results. Using a condition-specific questionnaire (Consequences of Screening in Breast Cancer), we assessed 12 psychosocial consequences at 5 time points (0, 1, 6, 18, and 36 months after final diagnosis......) and compared the 2 groups of women with false-positives (invasive and noninvasive management groups). RESULTS: Among the 252 women with false-positive mammography eligible forthis study, psychosocial consequences were similar for those managed invasivelyand those managed noninvasively during the 36 months...

Synthesis and thermal behaviour of pauflerite, β-VOSO4, and its α-modification

International Nuclear Information System (INIS)

Paufler, Peter; Filatov, Stanislav K.; Krzhizhanovskaya, Maria G.; Bubnova, Rimma S.; Russian Academy of Sciences, St. Peterburg

2014-01-01

Powder α-VOSO 4 was prepared by dehydration of VOSO 4 . 3H 2 O. β-VOSO 4 was synthesized by boiling of V 2 O 5 in H 2 SO 4 . Thermal behaviour of VOSO 4 . 3H 2 O, α- and β-VOSO 4 modifications is studied by high-temperature powder X-ray diffraction and thermal analysis, including two-step dehydration of VOSO 4 . 3H 2 O, formation of α-VOSO 4 , thermal expansion and decomposition of both modifications into V 2 O 5 . Higher anisotropy of thermal expansion of the tetragonal α-modification α c = 39(2) . 10 -6 K -1 along the vanadyl ion and α a = 2.4(6) . 10 -6 K -1 in the perpendicular direction comparing to the orthorhombic β-modification (α a = 20.2(7), α b = 2.8(8), α c = 17.8(4) . 10 -6 K -1 ) is explained from a crystal chemical point of view.

Highly Sensitive and High-Throughput Analysis of Plant Hormones Using MS-Probe Modification and Liquid Chromatography–Tandem Mass Spectrometry: An Application for Hormone Profiling in Oryza sativa

Science.gov (United States)

Kojima, Mikiko; Kamada-Nobusada, Tomoe; Komatsu, Hirokazu; Takei, Kentaro; Kuroha, Takeshi; Mizutani, Masaharu; Ashikari, Motoyuki; Ueguchi-Tanaka, Miyako; Matsuoka, Makoto; Suzuki, Koji; Sakakibara, Hitoshi

2009-01-01

We have developed a highly sensitive and high-throughput method for the simultaneous analysis of 43 molecular species of cytokinins, auxins, ABA and gibberellins. This method consists of an automatic liquid handling system for solid phase extraction and ultra-performance liquid chromatography (UPLC) coupled with a tandem quadrupole mass spectrometer (qMS/MS) equipped with an electrospray interface (ESI; UPLC-ESI-qMS/MS). In order to improve the detection limit of negatively charged compounds, such as gibberellins, we chemically derivatized fractions containing auxin, ABA and gibberellins with bromocholine that has a quaternary ammonium functional group. This modification, that we call ‘MS-probe’, makes these hormone derivatives have a positive ion charge and permits all compounds to be measured in the positive ion mode with UPLC-ESI-qMS/MS in a single run. Consequently, quantification limits of gibberellins increased up to 50-fold. Our current method needs 180 plant samples simultaneously. Application of this method to plant hormone profiling enabled us to draw organ distribution maps of hormone species in rice and also to identify interactions among the four major hormones in the rice gibberellin signaling mutants, gid1-3, gid2-1 and slr1. Combining the results of hormone profiling data with transcriptome data in the gibberellin signaling mutants allows us to analyze relationships between changes in gene expression and hormone metabolism. PMID:19369275

Effectiveness of participatory adolescent strategic health action (PASHA for lifestyle modification among adolescents

Directory of Open Access Journals (Sweden)

Asha P Shetty

2015-01-01

Full Text Available Introduction: Lifestyle modification is one of the methods to promote healthy lifestyle among adolescents. In this study, the researcher planned to develop, implement and evaluate a need based Participatory Adolescent Strategic Health Action (PASHA for lifestyle modification among selected adolescents. Materials and Methods: An evaluative approach with Quasi experimental one group pretest post test design (time series was adopted. Sample constituted 103 adolescents, aged 12-17 years studying in high schools and pre university colleges of Udupi district selected based on convenient sampling. Data was gathered using reliable and valid tools. Results: The mean combined preventive health lifestyle score among all adolescents increased from 75.65-81.56. Similarly the number of adolescents with healthy lifestyle score also increased from 28.2-53.4% after practicing for 180 days. Analysis of all the components of lifestyle showed that the adolescents had adopted healthy lifestyle practices in all the components of lifestyle. The number of adolescents with combined health status score also showed an increase from 31.1-54.4% after implementing PASHA practice. Analysis of reported outcome among subjects indicated that PASHA was motivating to improve their lifestyle practices. Conclusion: PASHA was found to be effective in lifestyle modification of adolescents. It is reiterated that when lifestyle modification is to be done, a strategy to improve self directedness and self efficacy should be adopted.

Health effects models for nuclear power plant accident consequence analysis

International Nuclear Information System (INIS)

Evans, J.S.; Abrahmson, S.; Bender, M.A.; Boecker, B.B.; Scott, B.R.; Gilbert, E.S.

1993-10-01

This report is a revision of NUREG/CR-4214, Rev. 1, Part 1 (1990), Health Effects Models for Nuclear Power Plant Accident Consequence Analysis. This revision has been made to incorporate changes to the Health Effects Models recommended in two addenda to the NUREG/CR-4214, Rev. 1, Part 11, 1989 report. The first of these addenda provided recommended changes to the health effects models for low-LET radiations based on recent reports from UNSCEAR, ICRP and NAS/NRC (BEIR V). The second addendum presented changes needed to incorporate alpha-emitting radionuclides into the accident exposure source term. As in the earlier version of this report, models are provided for early and continuing effects, cancers and thyroid nodules, and genetic effects. Weibull dose-response functions are recommended for evaluating the risks of early and continuing health effects. Three potentially lethal early effects -- the hematopoietic, pulmonary, and gastrointestinal syndromes are considered. Linear and linear-quadratic models are recommended for estimating the risks of seven types of cancer in adults - leukemia, bone, lung, breast, gastrointestinal, thyroid, and ''other''. For most cancers, both incidence and mortality are addressed. Five classes of genetic diseases -- dominant, x-linked, aneuploidy, unbalanced translocations, and multifactorial diseases are also considered. Data are provided that should enable analysts to consider the timing and severity of each type of health risk

76 FR 65769 - Airport Improvement Program: Modifications to Benefit Cost Analysis (BCA) Threshold

Science.gov (United States)

2011-10-24

... have risen faster than the general rate of inflation. Since we were unable to locate construction cost... enables us to best respond. B. Modifications to Policy The previous AIP grant policy, issued June 24, 1997... established a docket and invited airport sponsors and other interested parties to comment on the BCA...

Structure Modification of an Active Azo-Compound as a Route to New Antimicrobial Compounds

Directory of Open Access Journals (Sweden)

Simona Concilio

2017-05-01

Full Text Available Some novel (phenyl-diazenylphenols 3a–g were designed and synthesized to be evaluated for their antimicrobial activity. A previously synthesized molecule, active against bacteria and fungi, was used as lead for modifications and optimization of the structure, by introduction/removal or displacement of hydroxyl groups on the azobenzene rings. The aim of this work was to evaluate the consequent changes of the antimicrobial activity and to validate the hypothesis that, for these compounds, a plausible mechanism could involve an interaction with protein receptors, rather than an interaction with membrane. All newly synthesized compounds were analyzed by 1H-NMR, DSC thermal analysis and UV-Vis spectroscopy. The in vitro minimal inhibitory concentrations (MIC of each compound was determined against Gram-positive and Gram-negative bacteria and Candida albicans. Compounds 3b and 3g showed the highest activity against S. aureus and C. albicans, with remarkable MIC values of 10 µg/mL and 3 µg/mL, respectively. Structure-activity relationship studies were capable to rationalize the effect of different substitutions on the phenyl ring of the azobenzene on antimicrobial activity.

The modification of main steam safety valves in Qinshan phase Ⅱ expansion project

International Nuclear Information System (INIS)

Chen Haiqiao

2012-01-01

The main steam safety valves of NPP steam system are second- class nuclear safety component. It used to limit the pressure of SG secondary side and main steam system via emitting steam into the environment. At present, the main steam safety valves have mechanical valves and assisted power valves. According to the experience of power plants at home and abroad, including Qinshan Phase Ⅱ unit 1/2 experience feedback, Qinshan Phase Ⅱ expansion project made modification on valve type, setting value and valve body. This paper introduce the characteristics of different safety valve types, the modification of main steam safety valves and the modification analysis on safety issues.security and impact on the other systems in Qinshan Phase Ⅱ expansion project. (author)

An overview of the facilities, activities, and developments at the University of North Texas Ion Beam Modification and Analysis Laboratory (IBMAL)

Science.gov (United States)

Rout, Bibhudutta; Dhoubhadel, Mangal S.; Poudel, Prakash R.; Kummari, Venkata C.; Pandey, Bimal; Deoli, Naresh T.; Lakshantha, Wickramaarachchige J.; Mulware, Stephen J.; Baxley, Jacob; Manuel, Jack E.; Pacheco, Jose L.; Szilasi, Szabolcs; Weathers, Duncan L.; Reinert, Tilo; Glass, Gary A.; Duggan, Jerry L.; McDaniel, Floyd D.

2013-07-01

The Ion Beam Modification and Analysis Laboratory (IBMAL) at the University of North Texas includes several accelerator facilities with capabilities of producing a variety of ion beams from tens of keV to several MeV in energy. The four accelerators are used for research, graduate and undergraduate education, and industrial applications. The NEC 3MV Pelletron tandem accelerator has three ion sources for negative ions: He Alphatross and two different SNICS-type sputter ion sources. Presently, the tandem accelerator has four high-energy beam transport lines and one low-energy beam transport line directly taken from the negative ion sources for different research experiments. For the low-energy beam line, the ion energy can be varied from ˜20 to 80 keV for ion implantation/modification of materials. The four post-acceleration beam lines include a heavy-ion nuclear microprobe; multi-purpose PIXE, RBS, ERD, NRA, and broad-beam single-event upset; high-energy ion implantation line; and trace-element accelerator mass spectrometry. The NEC 3MV single-ended Pelletron accelerator has an RF ion source mainly for hydrogen, helium and heavier inert gases. We recently installed a capacitive liner to the terminal potential stabilization system for high terminal voltage stability and high-resolution microprobe analysis. The accelerator serves a beam line for standard RBS and RBS/C. Another beamline for high energy focused ion beam application using a magnetic quadrupole lens system is currently under construction. This beam line will also serve for developmental work on an electrostatic lens system. The third accelerator is a 200 kV Cockcroft-Walton accelerator with an RF ion source. The fourth accelerator is a 2.5 MV Van de Graaff accelerator, which was in operation for last several decades is currently planned to be used mainly for educational purpose. Research projects that will be briefly discussed include materials synthesis/modification for photonic, electronic, and

An overview of the facilities, activities, and developments at the University of North Texas Ion Beam Modification and Analysis Laboratory (IBMAL)

Energy Technology Data Exchange (ETDEWEB)

Rout, Bibhudutta; Dhoubhadel, Mangal S.; Poudel, Prakash R.; Kummari, Venkata C.; Pandey, Bimal; Deoli, Naresh T.; Lakshantha, Wickramaarachchige J.; Mulware, Stephen J.; Baxley, Jacob; Manuel, Jack E.; Pacheco, Jose L.; Szilasi, Szabolcs; Weathers, Duncan L.; Reinert, Tilo; Glass, Gary A.; Duggan, Jerry L.; McDaniel, Floyd D. [Ion Beam Modification and Analysis Laboratory, University of North Texas, Department of Physics, 1155 Union Circle 311427, Denton, Texas 76203 (United States)

2013-07-03

The Ion Beam Modification and Analysis Laboratory (IBMAL) at the University of North Texas includes several accelerator facilities with capabilities of producing a variety of ion beams from tens of keV to several MeV in energy. The four accelerators are used for research, graduate and undergraduate education, and industrial applications. The NEC 3MV Pelletron tandem accelerator has three ion sources for negative ions: He Alphatross and two different SNICS-type sputter ion sources. Presently, the tandem accelerator has four high-energy beam transport lines and one low-energy beam transport line directly taken from the negative ion sources for different research experiments. For the low-energy beam line, the ion energy can be varied from {approx}20 to 80 keV for ion implantation/modification of materials. The four post-acceleration beam lines include a heavy-ion nuclear microprobe; multi-purpose PIXE, RBS, ERD, NRA, and broad-beam single-event upset; high-energy ion implantation line; and trace-element accelerator mass spectrometry. The NEC 3MV single-ended Pelletron accelerator has an RF ion source mainly for hydrogen, helium and heavier inert gases. We recently installed a capacitive liner to the terminal potential stabilization system for high terminal voltage stability and high-resolution microprobe analysis. The accelerator serves a beam line for standard RBS and RBS/C. Another beamline for high energy focused ion beam application using a magnetic quadrupole lens system is currently under construction. This beam line will also serve for developmental work on an electrostatic lens system. The third accelerator is a 200 kV Cockcroft-Walton accelerator with an RF ion source. The fourth accelerator is a 2.5 MV Van de Graaff accelerator, which was in operation for last several decades is currently planned to be used mainly for educational purpose. Research projects that will be briefly discussed include materials synthesis/modification for photonic, electronic, and

Mission Analysis for Using Preventive Radiological/Nuclear Detection Equipment for Consequence Management

Energy Technology Data Exchange (ETDEWEB)

Buddemeier, Brooke R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Wood-Zika, Annmarie R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Haynes, Daniel [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Klemic, Gladys A. [US Dept. of Homeland Security National Urban Security Technology Lab., Manhattan, NY (United States); Musolino, Stephen V. [Brookhaven National Lab. (BNL), Upton, NY (United States)

2017-09-01

The overall objective of this project is to research, evaluate, and test first responder preventive radiological/nuclear detection (PRND) equipment to provide state and local agencies with scientific guidance on how to effectively use this equipment for response after a radiological/nuclear release or detonation. While the equipment being tested in this effort has been specifically designed by technology manufacturers and purchased by responders for preventive detection and source interdiction operations, the fleet of PRND equipment can help fill critical needs for radiological instrumentation should a consequence management (CM) response take place, as it is currently the most widely available and fielded radiological instrumentation by state and local agencies. This effort will provide scientific guidance on the most effective way to utilize this class of equipment for consequence management missions. Gaining a better understanding of how PRND equipment can operate and perform for these missions will allow for recommendations on the tactical approach responders can use for consequence management operations. PRND equipment has been placed into service by federal, state, and local agencies throughout the nation. If the equipment capability and limitations are taken into account, this large inventory can be leveraged to support the emergency response in the aftermath of a radiological or nuclear event. With several hundred makes and models of PRND equipment, often with significantly different detection capabilities that do not align with their nominal PRND equipment type, development of a streamlined categorization scheme with respect to consequence management missions was the first step to identifying safe and effective uses of PRND equipment for radiological/nuclear incident response.

Chemical Modifications of Starch: Microwave Effect

OpenAIRE

Lewicka, Kamila; Siemion, Przemysław; Kurcok, Piotr

2015-01-01

This paper presents basic methods of starch chemical modification, the effect of microwave radiation on the modification process, and the physicochemical properties of starch. It has been shown that the modifications contribute to improvement of the material performance and likewise to significant improvement of its mechanical properties. As a result, more and more extensive use of starch is possible in various industries. In addition, methods of oxidized starch and starch esters preparation ...

Evaluation of nuclear accidents consequences. Risk assessment methodologies, current status and applications

International Nuclear Information System (INIS)

Rodriguez, J.M.

1996-01-01

General description of the structure and process of the probabilistic methods of assessment the external consequences in the event of nuclear accidents is presented. attention is paid in the interface with Probabilistic Safety Analysis level 3 results (source term evaluation) Also are described key issues in accident consequence evaluation as: effects evaluated (early and late health effects and economic effects due to countermeasures), presentation of accident consequences results, computer codes. Briefly are presented some relevant areas for the applications of Accident Consequence Evaluation

Adaptive Control for Linear Uncertain Systems with Unmodeled Dynamics Revisited via Optimal Control Modification

Science.gov (United States)

Nguyen, Nhan

2013-01-01

This paper presents the optimal control modification for linear uncertain plants. The Lyapunov analysis shows that the modification parameter has a limiting value depending on the nature of the uncertainty. The optimal control modification exhibits a linear asymptotic property that enables it to be analyzed in a linear time invariant framework for linear uncertain plants. The linear asymptotic property shows that the closed-loop plants in the limit possess a scaled input-output mapping. Using this property, we can derive an analytical closed-loop transfer function in the limit as the adaptive gain tends to infinity. The paper revisits the Rohrs counterexample problem that illustrates the nature of non-robustness of model-reference adaptive control in the presence of unmodeled dynamics. An analytical approach is developed to compute exactly the modification parameter for the optimal control modification that stabilizes the plant in the Rohrs counterexample. The linear asymptotic property is also used to address output feedback adaptive control for non-minimum phase plants with a relative degree 1.

The ABBA study - approach bias modification in bulimia nervosa and binge eating disorder: study protocol for a randomised controlled trial

OpenAIRE

Brockmeyer, Timo; Schmidt, Ulrike Hermine; Friederich, H C

2016-01-01

Background: The core symptoms of bulimia nervosa (BN) and binge eating disorder (BED) are recurrent episodes of binge eating. Despite negative psychological and physical consequences, BN/BED patients show uncontrollable approach tendencies towards food. This cognitive bias occurs at an early stage of information processing. Cognitive bias modification (CBM) directly targets such biases and has been shown to be effective in treating several mental disorders. In alcohol addiction, automatic act...

Modification of enzymes by use of high-pressure homogenization.

Science.gov (United States)

Dos Santos Aguilar, Jessika Gonçalves; Cristianini, Marcelo; Sato, Helia Harumi

2018-07-01

High-pressure is an emerging and relatively new technology that can modify various molecules. High-pressure homogenization (HPH) has been used in several studies on protein modification, especially in enzymes used or found in food, from animal, plant or microbial resources. According to the literature, the enzymatic activity can be modulated under pressure causing inactivation, stabilization or activation of the enzymes, which, depending on the point of view could be very useful. Homogenization can generate changes in the structure of the enzyme modifying various chemical bonds (mainly weak bonds) causing different denaturation levels and, consequently, affecting the catalytic activity. This review aims to describe the various alterations due to HPH treatment in enzymes, to show the influence of high-pressure on proteins and to report the HPH effects on the enzymatic activity of different enzymes employed in the food industry and research. Copyright © 2018 Elsevier Ltd. All rights reserved.

Covalent modifications of the amyloid beta peptide by hydroxynonenal: Effects on metal ion binding by monomers and insights into the fibril topology.

Science.gov (United States)

Grasso, G; Komatsu, H; Axelsen, P H

2017-09-01

Amyloid β peptides (Aβ) and metal ions are associated with oxidative stress in Alzheimer's disease (AD). Oxidative stress, acting on ω-6 polyunsaturated fatty acyl chains, produces diverse products, including 4-hydroxy-2-nonenal (HNE), which can covalently modify the Aβ that helped to produce it. To examine possible feedback mechanisms involving Aβ, metal ions and HNE production, the effects of HNE modification and fibril formation on metal ion binding was investigated. Results indicate that copper(II) generally inhibits the modification of His side chains in Aβ by HNE, but that once modified, copper(II) still binds to Aβ with high affinity. Fibril formation protects only one of the three His residues in Aβ from HNE modification, and this protection is consistent with proposed models of fibril structure. These results provide insight into a network of biochemical reactions that may be operating as a consequence of oxidative stress in AD, or as part of the pathogenic process. Copyright © 2016. Published by Elsevier Inc.

Surface modification of polyethylene by plasma; Modificacion superficial de polietileno por plasma

Energy Technology Data Exchange (ETDEWEB)

Colin O, E

2003-07-01

The products made of polyethylene (PE) go from construction materials, electric insulating until packing material. The films for bags and pack occupy 83.6% of the distribution of the market of PE approximately. The enormous quantity of PE that is generated by its indiscriminate use brings as consequence a deterioration to the atmosphere, due to the long life that they present as waste. This work is a study on the modification of low density polyethylene films. In this type of thin materials, the changes in the surface meet with largely on the conformation of the rest of the material. To induce changes that modify the surface of PE, plasmas were used with reactive atmospheres of air, oxygen and nitrogen. The experimentation that was carries out went to introduce the PE to a cylindrical reactor where it was generated the plasma of air, oxygen and nitrogen to different times of exposure. After having carried out the exposure to the plasma, it was found that in the polyethylene it modifies their morphology, crystallinity, hydrophobicity, composition and electric conductivity. The analytical techniques that were used to characterize later to the polyethylene of being in contact with the plasma were: X-ray diffraction, Scanning Electron Microscopy, Infrared spectroscopy, Electric conductivity, Angle of contact and finally Thermal Gravimetric Analysis. The content of this work it is presented in five chapters: In the chapter 1 there are presented some general concepts of plasma and of the one polymer in study PE. In the chapter 2 it is made a general revision on modification of surfaces, as well as the properties that were modified in polymeric materials that were exposed to plasma in previous works. In the chapter 3 the experimental part and the conditions used are described in the modification of the PE. Also in this chapter a brief description it is made of the used characterization techniques. The results and discussion are presented in the chapter 4. These results

Factor Structure of Individual Consequences for Teleworking Professionals

Directory of Open Access Journals (Sweden)

John Campbell

2016-06-01

Full Text Available Despite the increasing popularity of telework, little is known about individual outcomes that arise particularly for teleworking professionals. We build on earlier research by examining the conceptual constructs of individual consequences from telework. We initially categorized consequences identified in the extant literature into five areas. However, this model was not supported by confirmatory factor analysis of survey data collected from 250 teleworking accounting professionals. Subsequent exploratory factor analysis revealed a more complex six-factor structure relating to (1 Effectiveness; (2 Self-assurance; (3 Working with Others; (4 Work Pressure; (5 Professional Image; and (6 Physicality. The results extend our understanding of latent constructs underlying telework by professional knowledge workers, and provide a basis for further refinement of our model based on empirical research and theoretical development.

Application of radiation technology in starch modification

International Nuclear Information System (INIS)

Chen Huiyuan; Peng Zhigang; Ding Zhongmin; Lu Jiajiu

2007-01-01

In order to commercialize the radiation modification of starch, corn starch was irradiated with different dose of 60 Co gamma radiations. Some basic physical and chemical properties of the resulted modified starch paste were measured with emphasis on the viscosity stability and tensile strength. The results indicate that irradiation of corn starch with a dose of 4-10 kGy can decrease its viscosity to 5-14 mPa·s, and the tensile strength can meet the standard set up for textile paste. In comparison with chemical modification for starch, radiation modification is simpler in technology, more convenient in operation, more stable in modification quality, and easier to control. The mechanism of radiation modification of starch was also discussed. (authors)

Use of the deterministic safety analyses in support to the NPP Krsko modification

International Nuclear Information System (INIS)

Feretic, D.; Cavlina, N.; Debrecin, N.; Grgic, D.; Bajs, T.; Spalj, S.

2004-01-01

The ultimate goal of the safety analysis is to verify that Nuclear Power Plant (NPP) meets safety and operational requirements. To this aim it is necessary to demonstrate that plant safety has not been deteriorated in the case of the modifications to the plant Systems, Structures and Components (SSC) or changes to the plant procedures. In addition, safety analyses are needed in the case of reassessment of an existing plant. The reasons for reassessment may be different, e.g. due to the changes in the methodology and assumptions used in the original design, if the original design basis or acceptance criteria may no longer be adequate, if the safety analysis tools used may have been superseded by more sophisticated methods or if the original design basis may no longer be met. The operation of the NPP Krsko has experienced numerous changes from the original design for the majority of the reasons that have been mentioned before. On the other side, the application of the large best-estimate thermalhydraulic codes has evolved to the wide spread support in the operation of the NPP: compliance with the regulatory goals, support to the PSA studies, analysis of the operational transients, plant modifications studies, equipment qualification, training of the operators, preparation of the operating procedures, etc. This trend has been followed at the Faculty of Electrical Engineering Zagreb (FER) and applied to the on-going needs due to the modifications and changes at NPP Krsko. In this paper, an overview of the deterministic safety analyses performed at FER in the support to the NPP Krsko modifications and changes is presented.(author)

Ion Beam Materials Analysis and Modifications at keV to MeV Energies at the University of North Texas

Science.gov (United States)

Rout, Bibhudutta; Dhoubhadel, Mangal S.; Poudel, Prakash R.; Kummari, Venkata C.; Lakshantha, Wickramaarachchige J.; Manuel, Jack E.; Bohara, Gyanendra; Szilasi, Szabolcs Z.; Glass, Gary A.; McDaniel, Floyd D.

2014-02-01

The University of North Texas (UNT) Ion Beam Modification and Analysis Laboratory (IBMAL) has four particle accelerators including a National Electrostatics Corporation (NEC) 9SDH-2 3 MV tandem Pelletron, a NEC 9SH 3 MV single-ended Pelletron, and a 200 kV Cockcroft-Walton. A fourth HVEC AK 2.5 MV Van de Graaff accelerator is presently being refurbished as an educational training facility. These accelerators can produce and accelerate almost any ion in the periodic table at energies from a few keV to tens of MeV. They are used to modify materials by ion implantation and to analyze materials by numerous atomic and nuclear physics techniques. The NEC 9SH accelerator was recently installed in the IBMAL and subsequently upgraded with the addition of a capacitive-liner and terminal potential stabilization system to reduce ion energy spread and therefore improve spatial resolution of the probing ion beam to hundreds of nanometers. Research involves materials modification and synthesis by ion implantation for photonic, electronic, and magnetic applications, micro-fabrication by high energy (MeV) ion beam lithography, microanalysis of biomedical and semiconductor materials, development of highenergy ion nanoprobe focusing systems, and educational and outreach activities. An overview of the IBMAL facilities and some of the current research projects are discussed.

Adjustments in Almod3W2 transient analysis code to fit Angra 1 NPP experimental data

International Nuclear Information System (INIS)

Madeira, A.A.; Camargo, C.T.M.

1988-01-01

Some little modifications were introduced in ALMOD3W2 code, as consequence of the interest in reproducing the full load rejection test in Angra 1 NPP. Such modifications showed to be adequate when code results were compared with experimental data. (author) [pt

Modification of transparent materials with ultrashort laser pulses: What is energetically and mechanically meaningful?

Energy Technology Data Exchange (ETDEWEB)

Bulgakova, Nadezhda M., E-mail: nadezhda.bulgakova@hilase.cz [HiLASE Centre, Institute of Physics ASCR, Za Radnicí 828, 25241 Dolní Břežany (Czech Republic); Institute of Thermophysics SB RAS, 1 Lavrentyev Ave., 630090 Novosibirsk (Russian Federation); Zhukov, Vladimir P. [Institute of Computational Technologies SB RAS, 6 Lavrentyev Ave., 630090 Novosibirsk (Russian Federation); Novosibirsk State Technical University, 20 Karl Marx Ave., 630073, Novosibirsk (Russian Federation); Sonina, Svetlana V. [Novosibirsk State University, 1 Koptuga Ave., 630090 Novosibirsk (Russian Federation); Meshcheryakov, Yuri P. [Design and Technology Branch of Lavrentyev Institute of Hydrodynamics SB RAS, Tereshkovoi street 29, 630090 Novosibirsk (Russian Federation)

2015-12-21

A comprehensive analysis of laser-induced modification of bulk glass by single ultrashort laser pulses is presented which is based on combination of optical Maxwell-based modeling with thermoelastoplastic simulations of post-irradiation behavior of matter. A controversial question on free electron density generated inside bulk glass by ultrashort laser pulses in modification regimes is addressed on energy balance grounds. Spatiotemporal dynamics of laser beam propagation in fused silica have been elucidated for the regimes used for direct laser writing in bulk glass. 3D thermoelastoplastic modeling of material relocation dynamics under laser-induced stresses has been performed up to the microsecond timescale when all motions in the material decay. The final modification structure is found to be imprinted into material matrix already at sub-nanosecond timescale. Modeling results agree well with available experimental data on laser light transmission through the sample and the final modification structure.

Evaluation of radiological dispersion/consequence codes supporting DOE nuclear facility SARs

International Nuclear Information System (INIS)

O'Kula, K.R.; Paik, I.K.; Chung, D.Y.

1996-01-01

Since the early 1990s, the authorization basis documentation of many U.S. Department of Energy (DOE) nuclear facilities has been upgraded to comply with DOE orders and standards. In this process, many safety analyses have been revised. Unfortunately, there has been nonuniform application of software, and the most appropriate computer and engineering methodologies often are not applied. A DOE Accident Phenomenology and Consequence (APAC) Methodology Evaluation Program was originated at the request of DOE Defense Programs to evaluate the safety analysis methodologies used in nuclear facility authorization basis documentation and to define future cost-effective support and development initiatives. Six areas, including source term development (fire, spills, and explosion analysis), in-facility transport, and dispersion/ consequence analysis (chemical and radiological) are contained in the APAC program. The evaluation process, codes considered, key results, and recommendations for future model and software development of the Radiological Dispersion/Consequence Working Group are summarized in this paper

Pragmatic Graph Rewriting Modifications

OpenAIRE

Rodgers, Peter; Vidal, Natalia

1999-01-01

We present new pragmatic constructs for easing programming in visual graph rewriting programming languages. The first is a modification to the rewriting process for nodes the host graph, where nodes specified as 'Once Only' in the LHS of a rewrite match at most once with a corresponding node in the host graph. This reduces the previously common use of tags to indicate the progress of matching in the graph. The second modification controls the application of LHS graphs, where those specified a...

Morphology modification of gold nanoparticles from nanoshell to C-shape: Improved surface enhanced Raman scattering

International Nuclear Information System (INIS)

Xing, Ting-Yang; Zhu, Jian; Li, Jian-Jun; Zhao, Jun-Wu

2016-01-01

Morphology modification of nanostructures is of great interest, because it can be used to fabricate nanostructures which are hard to be done using other methods. Different from traditional lithographic technique which is slow and expensive, morphology modification is easy, cheap, and reproducible. In this paper, modification of the optical and morphological properties of a hollow gold nanoshell (HGNS) is achieved by using H 2 O 2 as an oxidizer. The reshaping of these nanostructures has been demonstrated as a consequence of an oxidation process in which HGNSs are dissolved by H 2 O 2 under the acidic conditions provided by HCl. We investigate the oxidation process by a transmission electron microscope and propose a reshaping model involving four different shapes (HGNS, HGNS with hole, gold nanoring, and C-shaped gold nanoparticle) which are corresponding to the oxidation products of HGNSs at different pH values. Besides, the surface enhanced Raman scattering (SERS) activity of each oxidation product has been evaluated by using rhodamine 6G as the Raman active probe. It has been observed that the C-shaped gold nanoparticles which are corresponding to the oxidation products at the minimum pH value have the highest SERS activity and this result can also be interpreted by discrete-dipole approximation simulations. We demonstrate that the morphology modification of HGNSs becomes possible in a controlled manner using wet chemistry and can be used in preparation of gold nanoparticles such as HGNS with hole, gold nanoring, and C-shaped gold nanoparticle with large SERS activity. These nanostructures must have potential use in many plasmonic areas, including sensing, catalysis, and biomedicine.

Morphology modification of gold nanoparticles from nanoshell to C-shape: Improved surface enhanced Raman scattering

Energy Technology Data Exchange (ETDEWEB)

Xing, Ting-Yang; Zhu, Jian; Li, Jian-Jun; Zhao, Jun-Wu, E-mail: nanoptzhao@163.com [The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi' an Jiaotong University, Xi' an 710049 (China)

2016-06-28

Morphology modification of nanostructures is of great interest, because it can be used to fabricate nanostructures which are hard to be done using other methods. Different from traditional lithographic technique which is slow and expensive, morphology modification is easy, cheap, and reproducible. In this paper, modification of the optical and morphological properties of a hollow gold nanoshell (HGNS) is achieved by using H{sub 2}O{sub 2} as an oxidizer. The reshaping of these nanostructures has been demonstrated as a consequence of an oxidation process in which HGNSs are dissolved by H{sub 2}O{sub 2} under the acidic conditions provided by HCl. We investigate the oxidation process by a transmission electron microscope and propose a reshaping model involving four different shapes (HGNS, HGNS with hole, gold nanoring, and C-shaped gold nanoparticle) which are corresponding to the oxidation products of HGNSs at different pH values. Besides, the surface enhanced Raman scattering (SERS) activity of each oxidation product has been evaluated by using rhodamine 6G as the Raman active probe. It has been observed that the C-shaped gold nanoparticles which are corresponding to the oxidation products at the minimum pH value have the highest SERS activity and this result can also be interpreted by discrete-dipole approximation simulations. We demonstrate that the morphology modification of HGNSs becomes possible in a controlled manner using wet chemistry and can be used in preparation of gold nanoparticles such as HGNS with hole, gold nanoring, and C-shaped gold nanoparticle with large SERS activity. These nanostructures must have potential use in many plasmonic areas, including sensing, catalysis, and biomedicine.

Some issues on radiological consequences analysis in site selection for nuclear power stations

International Nuclear Information System (INIS)

Chen Xiaoqiu; Yue Huiguo

2006-01-01

The three considerations, Site safety and environmental protection and emergency preparedness, are the focus of attention in the evaluation of the suitability of a site for nuclear power station. This paper summarized the basic regulatory requirements for the siting of nuclear power station, described the existing problems on radiological consequences analyses during the siting stage and discussed the is- sues that need to concern in the reviewing of the radiological consequences analyses in the siting appraisal stage. (authors)

Quantitative analysis of histone modifications: formaldehyde is a source of pathological n(6-formyllysine that is refractory to histone deacetylases.

Directory of Open Access Journals (Sweden)

Bahar Edrissi

Full Text Available Aberrant protein modifications play an important role in the pathophysiology of many human diseases, in terms of both dysfunction of physiological modifications and the formation of pathological modifications by reaction of proteins with endogenous electrophiles. Recent studies have identified a chemical homolog of lysine acetylation, N(6-formyllysine, as an abundant modification of histone and chromatin proteins, one possible source of which is the reaction of lysine with 3'-formylphosphate residues from DNA oxidation. Using a new liquid chromatography-coupled to tandem mass spectrometry method to quantify all N(6-methyl-, -acetyl- and -formyl-lysine modifications, we now report that endogenous formaldehyde is a major source of N(6-formyllysine and that this adduct is widespread among cellular proteins in all compartments. N(6-formyllysine was evenly distributed among different classes of histone proteins from human TK6 cells at 1-4 modifications per 10(4 lysines, which contrasted strongly with lysine acetylation and mono-, di-, and tri-methylation levels of 1.5-380, 5-870, 0-1400, and 0-390 per 10(4 lysines, respectively. While isotope labeling studies revealed that lysine demethylation is not a source of N(6-formyllysine in histones, formaldehyde exposure was observed to cause a dose-dependent increase in N(6-formyllysine, with use of [(13C,(2H2]-formaldehyde revealing unchanged levels of adducts derived from endogenous sources. Inhibitors of class I and class II histone deacetylases did not affect the levels of N(6-formyllysine in TK6 cells, and the class III histone deacetylase, SIRT1, had minimal activity (<10% with a peptide substrate containing the formyl adduct. These data suggest that N(6-formyllysine is refractory to removal by histone deacetylases, which supports the idea that this abundant protein modification could interfere with normal regulation of gene expression if it arises at conserved sites of physiological protein secondary

Posttranslational modifications of proteins : tools for functional proteomics [Methods in molecular biology, v. 194

National Research Council Canada - National Science Library

Kannicht, Christoph

2002-01-01

... single glycosylation sites in a protein. Additional powerful techniques facilitate the analysis of glycosylphosphatidylinositols, lipid modifications, protein phosphorylation and sulfation, protein methylation and acetylation, a-amidation...

Modification of the bubble rise model used in RELAP4/Mod5 computer code for transients analysis

International Nuclear Information System (INIS)

Scharfmann, E.

1981-01-01

To improve the separation phase and heat transfer models in RELAP4/MOD5 computer code, in order to make more realistic estimates of the thermohydraulic behavior of the core submitted to a loss-of-coolant accident, is the objective of this work. This research is directed to the accident analysis caused by small breaks in the primary circuit of PWR plants, where two-phase flow occurs most of the time. Calculation have been performed with the help of the original version of RELAP code, and the version containing the proposed modifications on this work. Comparing one results with the original ones, we arrive at the conclusion that our results show more conservative values of core pressure and coolant temperature, while the peak values of fuel temperature are not exceeded. (Author) [pt

The Czech Equity Market - Its Effectiveness and Macroeconomic Consequences

OpenAIRE

Helena Horská

2005-01-01

This paper examines features of the Czech stock market’s development from 1997 to 2003 and attempts to unveil the macroeconomic consequences of stock-price development. The analysis of the stock market’s behavior supports a cautionary stance on the hypothesis of the efficient-market theory, even in its weak form. Another finding, as regards the macroeconomic consequences of stock-price development, undermined the assumption of the positive wealth effect of rising stocks. In relation to GDP gr...

Distal vein patch as a form of autologus modification for infragenicular prosthetic bypass.

Science.gov (United States)

Totic, Dragan; Rustempasic, Nedzad; Djedovic, Muhamed; Solakovic, Sid; Vukas, Haris; Aslani, Ilijas; Krvavac, Alma; Rudalija, Dzejra; Ahmetasevic, Alen

2013-01-01

Preferred graft for infragenicular bypass is autologus vein. The problem is when there is not available autologus vein. Literature suggest that in these situations, prosthetic graft with some form of modification of distal anastomosis with autogenic tissue is valuable adjunctive. Frequently used modifications are Miller's cuff, Taylor's patch and St. Mary's boot. Recently, there are reports on "Distal vein patch" as a form of autologus modification which, due to its simplicity and patency rate, attracted attention. The aim of this study was to evaluate benefits of this novel modification by comparing its patencies with other autologus modification of distal anastomosis. Study was performed on 60 patients, diabetics, with critical limb ischemia (CLI). Patients were divided in two groups: Group with distal vein patch modification; and group with some other form modification - control group. Patients were followed at least 22 months. We examined patency of grafts by physical examination or using Color Doppler. For statistical purposes we used KIaplan Meier analysis and curve. Significance was determined by Mann-Whitney, Fisher's exact, Pearsons chi square or Student T test as appropriate. P value less than 0,05 was considered significant. Groups were fairly matched relative to demographics, risk factors, operative intervention and distal anastomosis site. There was not statistical difference in two year primary patency between distal vein patch and control group--50% vs 53% respectivly (X2 = 0,08; p = 0,773). Also, there was not statistically significant difference in extremity survival (77% vs 77%) and patient survival between groups (89% vs 93%; X2 = 2,458; p = 0,117). This study proved equivalent patencies of infragenicular prosthetic bypasses performed using distal vein patch technique as with any other modification of distal anastomosis.

Swift heavy ion induced modification of aliphatic polymers

Energy Technology Data Exchange (ETDEWEB)

Hossain, Umme Habiba

2015-01-15

In this thesis, the high energy heavy ion induced modification of aliphatic polymers is studied. Two polymer groups, namely polyvinyl polymers (PVF, PVAc, PVA and PMMA) and fluoropolymers (PVDF, ETFE, PFA and FEP) were used in this work. Polyvinyl polymers were investigated since they will be used as insulating materials in the superconducting magnets of the new ion accelerators of the planned International Facility for Antiproton and Ion Research (FAIR) at the GSI Helmholtz-Centre of Heavy Ion Research (GSI) in Darmstadt. In order to study ion-beam induced degradation, all polymer foils were irradiated at the GSI linear accelerator UNILAC using several projectiles (U, Au, Sm, Xe) and experimentation sites (beam lines X0 and M3) over a large fluence regime (1 x 10{sup 10} - 5 x 10{sup 12} ions/cm{sup 2}). Five independent techniques, namely infrared (FT-IR) and ultraviolet-visible (UV-Vis) spectroscopy, residual gas analysis (RGA), thermal gravimetric analysis (TGA), and mass loss analysis (ML), were used to analyze the irradiated samples. FT-IR spectroscopy revealed that ion irradiation led to the decrease of characteristic band intensities showing the general degradation of the polymers, with scission of side groups and the main backbone. As a consequence of the structural modification, new bands appeared. UV-Vis transmission analysis showed an absorption edge shift from the ultraviolet region towards the visible region indicating double bond and conjugated double bond formation. On-line massspectrometric residual gas analysis showed the release of small gaseous fragment molecules. TGA analysis gave evidence of a changed thermal stability. With ML analysis, the considerable mass loss was quantified. The results of the five complementary analytical methods show how heavy ion irradiation changes the molecular structure of the polymers. Molecular degradation mechanisms are postulated. The amount of radiation damage is found to be sensitive to the used type of ionic

Cognitive emotional consequences of male infertility in their female partners: a qualitative content analysis.

Science.gov (United States)

Karimi, Fatemeh Zahra; Taghipour, Ali; Roudsari, Robab Latifnejad; Kimiaei, Seyed Ali; Mazlom, Seyed Reza; Amirian, Maliheh

2015-11-01

Infertility, as a global phenomenon and one of the most important issues of reproductive health, affects women more often than men, even when the infertility is due to a male factor. The purpose of this study was to explore the cognitive emotional experiences of women faced with male infertility. This qualitative study was conducted in 2014-2015 in Mashhad, Iran. The perceptions and experiences of healthy women whose husbands were diagnosed with primary male factor infertility were investigated using a qualitative content analysis approach. Participants were selected through purposeful sampling, and data collection was conducted using in-depth semistructured interviews. Data were analyzed using conventional content analysis with MAXqda software. Study rigor was verified via criteria proposed by Lincoln and Guba. One main theme emerged through analysis entitled "cognitive emotional reactions confronting infertility diagnosis" with sub-themes of cognitive emotional reactions when confronted with male infertility diagnosis with subthemes of disbelief and denial, fear and apprehension, suffering and emotional distress, disappointment, frustration, confusion, and joy. The diagnosis of male infertility was associated with important emotional cognitive consequences for their female partners. Emotional support, providing new insights into how to treat the issue, and trying to shorten the process of diagnosis are necessary for these women. This kind of support could reduce the psychological effects of confrontation with the diagnosis of male infertility, including social insecurity for women.

Interlanguage request modification: a case in vocational college

Science.gov (United States)

Widanta, I. M. R. J.; Sitawati, A. A. R.; Suciani, N. K.; Handayani, L. N. C.

2018-01-01

There has been much attention given by scholars to the investigation of inter-language pragmatics (ILP), and some of them have been concentrating on how ILP speakers modify their speech acts (SA) of request. This study was aimed at investigating request modification produced by Indonesian English speakers. A group of 23 college students majoring in tourism was involved as research participants. The participants were given two tests using two role play cards with two hotel-context request situations, i.e. low imposing request (R-Rq) and high imposing request (R+ Rq). Pretest was given prior to and post-test was given upon treatment. The situation was chosen based on[1] exemplar generation1 model. The data of request utterances was analyzed and compared with request taxonomies proposed by some scholars. Data analysis showed that the research participants were more competent pragmatically upon the treatment, indicated with the fact where they were able to produce 13 request modification patterns being compared to 11 patterns prior to the treatment.

Surface Modification of Solution-Processed ZrO2 Films through Double Coating for Pentacene Thin-Film Transistors

Science.gov (United States)

Kwon, Jin-Hyuk; Bae, Jin-Hyuk; Lee, Hyeonju; Park, Jaehoon

2018-03-01

We report the modification of surface properties of solution-processed zirconium oxide (ZrO2) dielectric films achieved by using double-coating process. It is proven that the surface properties of the ZrO2 film are modified through the double-coating process; the surface roughness decreases and the surface energy increases. The present surface modification of the ZrO2 film contributes to an increase in grain size of the pentacene film, thereby increasing the field-effect mobility and decreasing the threshold voltage of the pentacene thin-film transistors (TFTs) having the ZrO2 gate dielectric. Herein, the molecular orientation of pentacene film is also studied based on the results of contact angle and X-ray diffraction measurements. Pentacene molecules on the double-coated ZrO2 film are found to be more tilted than those on the single-coated ZrO2 film, which is attributed to the surface modification of the ZrO2 film. However, no significant differences are observed in insulating properties between the single-and the double-coated ZrO2 dielectric films. Consequently, the characteristic improvements of the pentacene TFTs with the double-coated ZrO2 gate dielectric film can be understood through the increase in pentacene grain size and the reduction in grain boundary density.

Long-term Consequences of Early Parenthood

DEFF Research Database (Denmark)

Johansen, Eva Rye; Nielsen, Helena Skyt; Verner, Mette

(and to lesser extent employment), as fathers appear to support the family, especially when early parenthood is combined with cohabitation with the mother and the child. Heterogeneous effects reveal that individuals with a more favorable socioeconomic background are affected more severely than......Having children at an early age is known to be associated with unfavorable economic outcomes, such as lower education, employment and earnings. In this paper, we study the long-term consequences of early parenthood for mothers and fathers. Our study is based on rich register-based data that......, importantly, merges all childbirths to the children’s mothers and fathers, allowing us to study the consequences of early parenthood for both parents. We perform a sibling fixed effects analysis in order to account for unobserved family attributes that are possibly correlated with early parenthood...

Toward a Systemic Notion of Information: Practical Consequences

Directory of Open Access Journals (Sweden)

Nagib Callaos

2002-01-01

Full Text Available Our main purpose in this paper is to start a process of a systemic definition of the notion of information and to provide some initial practical consequences of it. We will try to do that providing: 1 a conceptual definition, following Ackoff's (1962 description and method of such a kind of definition, and 2 following Peirce's (1931-5,1958 conception of "meaning", where the practical consequences should be included. To our knowledge, no attempt has been done up to the present neither to find a Peircean meaning to the notion of information, nor to start a process of describing a systemic notion of information. Consequently, we will try to integrate the different definitions made on information. But to integrate we should first differentiate what is to be integrated. Thus, we will typify information conceptions in subjective and objective, providing brief description and analysis of each type, integrating them in the context of a systemic notion of information, and drawing the respective pragmatic consequences, as required by Peirce, for any meaning description, and by a pragmatic-teleological systemic epistemology (Churchmann, 1971

Analysis of the consequences of 'thermite' reaction

International Nuclear Information System (INIS)

Yorio, Daniel; Cincotta, Daniel O.; Camacho, Esteban F.; Bruno, Hernan R.; Boero, Norma L.

1999-01-01

The mixture of Al-U 3 O 8 is not in a state of chemical equilibrium, and at temperatures of between 850 degree C and 1000 degree C, it reacts exo thermally. This is known, in corresponding bibliography, as a 'Thermite reaction'. This mixture is used in the manufacturing of the plate-type fuel used in research reactors. It has been pointed out that the release of energy caused by this type of reactions might represent a risk in case of accidents in this type of reactor. Conclusions, in general, tend to indicate that no such risk exists, although no concrete assurance is given that this is the case, and this fact, therefore, leaves room for doubt. The objective of this paper is to provide an in-depth study of what happens to a fuel plate when it is subjected to thermite reaction. We will, furthermore, analyze the consequences of the release of energy generated by this type of reaction within the core of the reactor, clearly defining the problem for this type of fuel and this kind of reactor

The computational nature of memory modification.

Science.gov (United States)

Gershman, Samuel J; Monfils, Marie-H; Norman, Kenneth A; Niv, Yael

2017-03-15

Retrieving a memory can modify its influence on subsequent behavior. We develop a computational theory of memory modification, according to which modification of a memory trace occurs through classical associative learning, but which memory trace is eligible for modification depends on a structure learning mechanism that discovers the units of association by segmenting the stream of experience into statistically distinct clusters (latent causes). New memories are formed when the structure learning mechanism infers that a new latent cause underlies current sensory observations. By the same token, old memories are modified when old and new sensory observations are inferred to have been generated by the same latent cause. We derive this framework from probabilistic principles, and present a computational implementation. Simulations demonstrate that our model can reproduce the major experimental findings from studies of memory modification in the Pavlovian conditioning literature.

Work function modifications of graphite surface via oxygen plasma treatment

Science.gov (United States)

Duch, J.; Kubisiak, P.; Adolfsson, K. H.; Hakkarainen, M.; Golda-Cepa, M.; Kotarba, A.

2017-10-01

The surface modification of graphite by oxygen plasma was investigated experimentally (X-ray diffraction, nanoparticle tracking analysis, laser desorption ionization mass spectrometry, thermogravimetry, water contact angle) and by molecular modelling (Density Functional Theory). Generation of surface functional groups (mainly sbnd OHsurf) leads to substantial changes in electrodonor properties and wettability gauged by work function and water contact angle, respectively. The invoked modifications were analyzed in terms of Helmholtz model taking into account the theoretically determined surface dipole moment of graphite-OHsurf system (μ = 2.71 D) and experimentally measured work function increase (from 0.75 to 1.02 eV) to determine the sbnd OH surface coverage (from 0.70 to 1.03 × 1014 groups cm-2). Since the plasma treatment was confined to the surface, the high thermal stability of the graphite material was preserved as revealed by the thermogravimetric analysis. The obtained results provide a suitable quantitative background for tuning the key operating parameters of carbon electrodes: electronic properties, interaction with water and thermal stability.

Effects of nuclear elastic scattering and modifications of ion-electron equilibration power on advanced-fuel burns

International Nuclear Information System (INIS)

Galambos, J.D.

1983-01-01

The effects of Nuclear Elastic Scattering (NES) of fusion products and modifications of the ion-electron equilibration power on D-T and D-based advanced-fuel fusion plasmas are presented here. The processes causing the modifications to the equilibration power included here are: (1) depletion of low-energy electrons by Coulomb collisions with the ions; and (2) magnetic field effects on the energy transfer between the ions and the electrons. Both NES and the equilibration modifications affect the flow of power to the plasma ions, which is an important factor in the analysis of advanced-fuels. A Hot Ion Mode (HIM) analysis was used to investigate the changes in the minimum ignition requirements for Cat-D and D- 3 He plasmas, due to the changes in the allowable T/sub i/T/sub e/ for ignition from NES and equilibration modifications. Both of these effects have the strongest influence on the ignition requirements for high temperature (>50 keV), low beta (<15%) plasmas, where the cyclotron radiation power loss from the electrons (which is particularly sensitive to changes in the electron temperature) is large

Modifications to nuclear power plants. Safety guide

International Nuclear Information System (INIS)

2004-01-01

This Safety Guide was prepared under the IAEA's programme for safety standards for nuclear power plants. It supplements Section 7 of the Safety Requirements publication on Safety of Nuclear Power Plants: Operation, which establishes the safety requirements for the modification of nuclear power plants. Reasons for carrying out modifications to nuclear power plants may include: (1) maintaining or strengthening existing safety provisions and thus maintaining consistency with or improving on the current design. (2) recovering from plant faults. (3) improving the thermal performance or increasing the power rating of the plant. (4) increasing the maintainability of the plant, reducing the radiation exposure of personnel or reducing the costs of plant maintenance. And (5) extending the design life of the plant. Most modifications, made on the basis of operating experience, are intended to improve on the design or to improve operational performance and flexibility. Some are rendered necessary by new regulatory requirements, ageing of the plant or obsolescence of equipment. However, the benefits of regularly updating the plant design can be jeopardized if modifications are not kept under rigorous control throughout the lifetime of the plant. The need to reduce costs and improve efficiency, in combination with changes to the structure of the electricity generation sector of the economy in many countries, has led many companies to make changes in the structure of the operating organization for nuclear power plants. Whatever the reason for such organizational changes, consideration should be given to the effects of those changes with the aim of ensuring that they would have no impacts that would compromise the safety of the plant. The objective of this Safety Guide is to provide guidance and recommendations on controlling activities relating to modifications at nuclear power plants in order to reduce risk and to ensure that the configuration of the plant is at all times under

Modifications to nuclear power plants. Safety guide

International Nuclear Information System (INIS)

2007-01-01

This Safety Guide was prepared under the IAEA's programme for safety standards for nuclear power plants. It supplements Section 7 of the Safety Requirements publication on Safety of Nuclear Power Plants: Operation, which establishes the safety requirements for the modification of nuclear power plants. Reasons for carrying out modifications to nuclear power plants may include: (1) maintaining or strengthening existing safety provisions and thus maintaining consistency with or improving on the current design. (2) recovering from plant faults. (3) improving the thermal performance or increasing the power rating of the plant. (4) increasing the maintainability of the plant, reducing the radiation exposure of personnel or reducing the costs of plant maintenance. And (5) extending the design life of the plant. Most modifications, made on the basis of operating experience, are intended to improve on the design or to improve operational performance and flexibility. Some are rendered necessary by new regulatory requirements, ageing of the plant or obsolescence of equipment. However, the benefits of regularly updating the plant design can be jeopardized if modifications are not kept under rigorous control throughout the lifetime of the plant. The need to reduce costs and improve efficiency, in combination with changes to the structure of the electricity generation sector of the economy in many countries, has led many companies to make changes in the structure of the operating organization for nuclear power plants. Whatever the reason for such organizational changes, consideration should be given to the effects of those changes with the aim of ensuring that they would have no impacts that would compromise the safety of the plant. The objective of this Safety Guide is to provide guidance and recommendations on controlling activities relating to modifications at nuclear power plants in order to reduce risk and to ensure that the configuration of the plant is at all times under

Energy conservation potential of surface modification technologies

Energy Technology Data Exchange (ETDEWEB)

Le, H.K.; Horne, D.M.; Silberglitt, R.S.

1985-09-01

This report assesses the energy conservation impact of surface modification technologies on the metalworking industries. The energy conservation impact of surface modification technologies on the metalworking industries is assessed by estimating their friction and wear tribological sinks and the subsequent reduction in these sinks when surface modified tools are used. Ion implantation, coatings, and laser and electron beam surface modifications are considered.

Histone modifications: Cycling with chromosomal replication

DEFF Research Database (Denmark)

Thon, Genevieve

2008-01-01

Histone modifications tend to be lost during chromosome duplication. Several recent studies suggest that the RNA interference pathway becomes active during the weakened transcriptional repression occurring at centromeres in S phase, resulting in the re-establishment of histone modifications...

Surface modification of carbon/epoxy prepreg using oxygen plasma and its effect on the delamination resistance behavior of carbon/epoxy composites

International Nuclear Information System (INIS)

Kim, M.H.; Rhee, K.Y.; Kim, H.J.; Jung, D.H.

2007-01-01

It was shown in previous study that the fracture toughness of carbon/epoxy laminated composites could be significantly improved by modifying the surface of the prepreg using Ar + irradiation in an oxygen environment. In this study, the surface of carbon/epoxy prepreg was modified using an oxygen plasma to improve the delamination resistance behavior of carbon/epoxy laminated composites. The variation of the contact angle on the prepreg surface was determined as a function of the modification time, in order to determine the optimal modification time. An XPS analysis was conducted to investigate the chemical changes on the surface of the prepreg caused by the plasma modification. Mode I delamination resistance curves of the composites with and without surface modification were plotted as a function of the delamination increment. The results showed that the contact angle varied from ∼64 o to ∼47 o depending on the modification time and reached a minimum for a modification time of 30 min. The XPS analysis showed that the hydrophilic carbonyl C=O group was formed by the oxygen plasma modification. The results also showed that the delamination resistance behavior was significantly improved by the plasma modification of the prepreg. This improvement was caused by the better layer-to-layer adhesion as well as increased interfacial strength between the fibers and matrix

Modification of rubber surface by UV surface grafting

International Nuclear Information System (INIS)

Shanmugharaj, A.M.; Kim, Jin Kuk; Ryu, Sung Hun

2006-01-01

Rubber surface is subjected to ultraviolet radiation (UV) in the presence of allylamine and radiation sensitizer benzophenone (BP). Fourier transform infrared spectral studies reveal the presence of allylamine on the surface. The presence of irregular needle shapes on the surface as observed in scanning electron micrographs also confirms the polymerized allylamine on the surface. Allylamine coatings have been further confirmed from atomic force microscopy (AFM) analysis. Thermogravimetric analysis (TGA) reveals that allylamine coating on the rubber surface lowers the thermal degradation rate. The contact angle between the water and rubber surface decreases for the modified rubber surface confirming the surface modification due to UV surface grafting

Probabilistic risk assessment and its role in plant modifications

International Nuclear Information System (INIS)

Diederich, A.R.; McElroy, W.F.

1986-01-01

Electric Utilities today have a tool available to improve management's ability to evaluate nuclear power plant modifications (MODS). Probabilistic Risk Assessment (PRA), is a tool of choice since it can be applied to a specific situation such as MOD request review, bringing the perspectives of reliability, financial risk and consequences to the public in addition to the more rigid requirements like those associated with Quality Assurance or licensing criteria. The techniques used in the PRA process revolve about the creation and manipulation of Fault Trees and Event Trees, which are used to quantify the event sequences and reliability of plant systems in a logical framework. It is through these methods that chains of sequences, or events, are understood. The degree to which plant systems are modelled in the PRA can vary depending on resources and purpose. Philadelphia Elecrtric Company's PRA modelled ten (10) major systems but this number may increase during the application and updating process

The Iran nuclear ambitions and the international consequences

International Nuclear Information System (INIS)

2005-01-01

This analysis of the Iran situation concerning the nuclear policy, is presented and discussed in three parts: the data and hypothesis of the iranian nuclear program, the regional strategy of Iran and evolution scenario and their consequences. (A.L.B.)

Fall determinants and home modifications by occupational therapists to prevent falls: Facteurs déterminants des chutes et modifications du domicile effectuées par les ergothérapeutes pour prévenir les chutes.

Science.gov (United States)

Maggi, Patrick; de Almeida Mello, Johanna; Delye, Sam; Cès, Sophie; Macq, Jean; Gosset, Christiane; Declercq, Anja

2018-02-01

Approximately one third of older people over 65 years fall each year. Home modifications may decrease occurrence of falls. This study aims to determine the risk factors of falls for frail older persons and to evaluate the impact of home modifications by an occupational therapist on the occurrence of falls. We conducted a longitudinal study using a quasiexperimental design to examine occurrence of falls. All participants 65 years of age and older and were assessed at baseline and 6 months after the intervention. Bivariate analysis and logistic regression models were used to study the risk factors of falls and the effect of home modifications on the incidence of falls. The main predictors of falls were vision problems, distress of informal caregiver, and insufficient informal support. Home modifications provided by an occupational therapist showed a significant reduction of falls. Informal caregivers and their health status had an impact on the fall risk of frail older persons. Home modifications by an occupational therapist reduced the fall risk of frail older persons at 6-months follow-up.

Design and verification of computer-based reactor control system modification at Bruce-A candu nuclear generating station

International Nuclear Information System (INIS)

Basu, S.; Webb, N.

1995-01-01

The Reactor Control System at Bruce-A Nuclear Generating Station is going through some design modifications, which involve a rigorous design process including independent verification and validation. The design modification includes changes to the control logic, alarms and annunciation, hardware and software. The design (and verification) process includes design plan, design requirements, hardware and software specifications, hardware and software design, testing, technical review, safety evaluation, reliability analysis, failure mode and effect analysis, environmental qualification, seismic qualification, software quality assurance, system validation, documentation update, configuration management, and final acceptance. (7 figs.)

Health effects models for off-site radiological consequence analysis on nuclear reactor accidents (II)

Energy Technology Data Exchange (ETDEWEB)

Homma, Toshimitsu [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Takahashi, Tomoyuki [Kyoto Univ., Kumatori, Osaka (Japan). Research Reactor Inst; Yonehara, Hidenori [National Inst. of Radiological Sciences, Chiba (Japan)] [eds.

2000-12-01

This report is a revision of JAERI-M 91-005, 'Health Effects Models for Off-Site Radiological Consequence Analysis of Nuclear Reactor Accidents'. This revision provides a review of two revisions of NUREG/CR-4214 reports by the U.S. Nuclear Regulatory Commission which is the basis of the JAERI health effects models and other several recent reports that may impact the health effects models by international organizations. The major changes to the first version of the JAERI health effects models and the recommended parameters in this report are for late somatic effects. These changes reflect recent changes in cancer risk factors that have come from longer followup and revised dosimetry in major studies on the Japanese A-bomb survivors. This report also provides suggestions about future revisions of computational aspects on health effects models. (author)

Health effects models for off-site radiological consequence analysis on nuclear reactor accidents (II)

International Nuclear Information System (INIS)

Homma, Toshimitsu

2000-12-01

This report is a revision of JAERI-M 91-005, 'Health Effects Models for Off-Site Radiological Consequence Analysis of Nuclear Reactor Accidents'. This revision provides a review of two revisions of NUREG/CR-4214 reports by the U.S. Nuclear Regulatory Commission which is the basis of the JAERI health effects models and other several recent reports that may impact the health effects models by international organizations. The major changes to the first version of the JAERI health effects models and the recommended parameters in this report are for late somatic effects. These changes reflect recent changes in cancer risk factors that have come from longer followup and revised dosimetry in major studies on the Japanese A-bomb survivors. This report also provides suggestions about future revisions of computational aspects on health effects models. (author)

75 FR 41529 - Petitions for Modification

Science.gov (United States)

2010-07-16

... application of existing mandatory safety standards published in Title 30 of the Code of Federal Regulations... DEPARTMENT OF LABOR Mine Safety and Health Administration Petitions for Modification AGENCY: Mine Safety and Health Administration (MSHA), Labor. ACTION: Notice of petitions for modification of existing...

75 FR 29784 - Petitions for Modification

Science.gov (United States)

2010-05-27

... application of existing mandatory safety standards published in Title 30 of the Code of Federal Regulations... DEPARTMENT OF LABOR Mine Safety and Health Administration Petitions for Modification AGENCY: Mine Safety and Health Administration (MSHA), Labor. ACTION: Notice of petitions for modification of existing...

75 FR 34486 - Petitions for Modification

Science.gov (United States)

2010-06-17

... application of existing mandatory safety standards published in Title 30 of the Code of Federal Regulations... DEPARTMENT OF LABOR Mine Safety and Health Administration Petitions for Modification AGENCY: Mine Safety and Health Administration (MSHA), Labor. ACTION: Notice of petitions for modification of existing...

Accident consequence analysis models applied to licensing process of nuclear installations, radioactive and conventional industries

International Nuclear Information System (INIS)

Senne Junior, Murillo; Vasconcelos, Vanderley de; Jordao, Elizabete

2002-01-01

The industrial accidents happened in the last years, particularly in the eighty's decade, had contributed in a significant way to call the attention to government authorities, industry and society as a whole, demanding mechanisms for preventing episodes that could affect people's safety and environment quality. Techniques and methods already thoroughly used in the nuclear, aeronautic and war industries were then adapted for performing analysis and evaluation of the risks associated to other industrial activities, especially in the petroleum, chemistry and petrochemical areas. Some models for analyzing the consequences of accidents involving fire and explosion, used in the licensing processes of nuclear and radioactive facilities, are presented in this paper. These models have also application in the licensing of conventional industrial facilities. (author)

Post-Translational Modifications of TRP Channels

Directory of Open Access Journals (Sweden)

Olaf Voolstra

2014-04-01

Full Text Available Transient receptor potential (TRP channels constitute an ancient family of cation channels that have been found in many eukaryotic organisms from yeast to human. TRP channels exert a multitude of physiological functions ranging from Ca2+ homeostasis in the kidney to pain reception and vision. These channels are activated by a wide range of stimuli and undergo covalent post-translational modifications that affect and modulate their subcellular targeting, their biophysical properties, or channel gating. These modifications include N-linked glycosylation, protein phosphorylation, and covalent attachment of chemicals that reversibly bind to specific cysteine residues. The latter modification represents an unusual activation mechanism of ligand-gated ion channels that is in contrast to the lock-and-key paradigm of receptor activation by its agonists. In this review, we summarize the post-translational modifications identified on TRP channels and, when available, explain their physiological role.

A Systematic Review and Meta-Analysis of the Effect of Lifestyle Modification on Metabolic Control in Overweight Children

Directory of Open Access Journals (Sweden)

Angela Shin-Yu Lien

2017-01-01

Full Text Available Childhood obesity is associated with type 2 diabetes mellitus. We aimed to determine the effects of lifestyle modification programs on fasting plasma glucose (FPG levels in overweight children. We queried six relevant electronic databases and manually searched for studies published before December 2016. Overweight/obese children who underwent a lifestyle modification for more than 6 months were included. A total of 3923 children from eight randomized controlled trials (RCTs were included. Compared with the control group, the lifestyle modification group had significantly lower FPG levels by 1.3 mg/dL. The mean differences were significantly decreased for both secondary outcomes; BMI z-score decreased by 0.16 units and insulin levels decreased by 2.4 mU/L. The metaregression showed that the follow-up duration was associated with FPG levels and BMI and insulin levels and half year is a suitable follow-up duration for this population. This study showed that lifestyle modification programs may be effective in reducing the FPG levels of overweight/obese children. Further high-quality RCTs with longer follow-up periods are needed to evaluate the long-term effect of this complementary approach for diabetes mellitus prevention on overweight/obese children.

Hazard and consequence analysis for waste emplacement at the Waste Isolation Pilot Plant

International Nuclear Information System (INIS)

Gerstner, D.M.; Clayton, S.G.; Farrell, R.F.; McCormick, J.A.; Ortiz, C.; Standiford, D.L.

1996-01-01

The Carlsbad Area Office established and analyzed the safety bases for the design and operations as documented in the WIPP Safety Analysis Report (SAR). Additional independent efforts are currently underway to assess the hazards associated with the long-term (10,000 year) isolation period as required by 40 CFR 191. The structure of the WIPP SAR is unique due to the hazards involved, and the agreement between the State of New Mexico and the DOE regarding SAR content and format. However, the hazards and accident analysis philosophy as contained in DOE-STD-3009-94 was followed as closely as possible, while adhering to state agreements. Hazards associated with WIPP waste receipt, emplacement, and disposal operations were systematically identified using a modified Hazard and Operability Study (HAZOP) technique. The WIPP HAZOP assessed the potential internal, external, and natural phenomena events that can cause the identified hazards to develop into accidents. The hazard assessment identified deviations from the intended design and operation of the waste handling system, analyzed potential accident consequences to the public and workers, estimated likelihood of occurrence, and evaluated associated preventative and mitigative features. It was concluded from the assessment that the proposed WIPP waste emplacement operations and design are sufficient to ensure safety of the public, workers, and environment, over the 35 year disposal phase

Chemical modification of chitosan in the absence of solvent for diclofenac sodium removal: pH and kinetics studies

Energy Technology Data Exchange (ETDEWEB)

Pereira, Kerlaine Alexandre Araujo; Osorio, Luizangela Reis; Silva, Marcos Pereira; Silva Filho, Edson Cavalcanti da, E-mail: edsonfilho@ufpi.edu.br [Universidade Federal do Piaui (UFPI/CCN), Teresina, PI (Brazil). Centro de Ciencias da Natureza. Lab. Interdisciplinar de Materiais Avancados; Sousa, Kaline Soares [Universidade Federal da Paraiba (UFPB/CCEN), Joao Pessoa, PB (Brazil). Centro de Ciencias Exatas e da Natureza. Dept. de Quimica

2014-08-15

Chitosan was modified with acetylacetone and ethylenediamine in the absence of solvent. The new biopolymer obtained from the modification was characterized by elemental analysis and NMR 13C and applied in the removal of diclofenac sodium aqueous solution varying the pH and time. Through elemental analysis was possible to verify a decreasing in C/N relation after reaction with acetylacetone and an increasing after modification with ethylenediamine. From NMR analysis was verified the appearance of peaks around 160-210 ppm in both materials due to free carbonyl groups in the first step of the modification, besides the formation of imine bonds. The adsorption tests showed that the highest value occurred at pH 4 and from the results of the kinetic study was found that maximum adsorption occurred within 45 minutes and experimental data adjusted better to linear adjustment, following pseudo second-order model. The results show a material efficient in the removal of emerging pollutants. (author)

Physical Consequences of Mathematical Principles

Directory of Open Access Journals (Sweden)

Comay E.

2009-10-01

Full Text Available Physical consequences are derived from the following mathematical structures: the variational principle, Wigner’s classifications of the irreducible representations of the Poincar ́ e group and the duality invariance of the homogeneous Maxwell equations. The analysis is carried out within the validity domain of special relativity. Hierarchical re- lations between physical theories are used. Some new results are pointed out together with their comparison with experimental data. It is also predicted that a genuine Higgs particle will not be detected.

Economics: An Analysis of Unintended Consequences. Volume 1: Introduction to Microeconomics.

Science.gov (United States)

Schenk, Robert E.

This curriculum guide introduces high school students to the basic principles of microeconomics. Chapter 1 provides a basic definition of economics, while chapter 2 introduces a number of important economic concepts and ideas and examines reasons for unintended or unexpected consequences of decision-making. Chapter 3 considers how individual…

Conformational impact of structural modifications in 2-fluorocyclohexanone

Directory of Open Access Journals (Sweden)

Francisco A. Martins

2017-08-01

Full Text Available 2-Haloketones are building blocks that combine physical, chemical and biological features of materials and bioactive compounds, while organic fluorine plays a fundamental role in the design of performance organic molecules. Since these features are dependent on the three-dimensional chemical structure of a molecule, simple structural modifications can affect its conformational stability and, consequently, the corresponding physicochemical/biological property of interest. In this work, structural changes in 2-fluorocyclohexanone were theoretically studied with the aim at finding intramolecular interactions that induce the conformational equilibrium towards the axial or equatorial conformer. The interactions evaluated were hydrogen bonding, hyperconjugation, electrostatic and steric effects. While the gauche effect, originated from hyperconjugative interactions, does not appear to cause some preferences for the axial conformation of organofluorine heterocycles, more classical effects indeed rule the conformational equilibrium of the compounds. Spectroscopic parameters (NMR chemical shifts and coupling constants, which can be useful to determine the stereochemistry and the interactions operating in the series of 2-fluorocyclohexanone derivatives, were also calculated.

Dynamic analysis of the photoenhancement process of colloidal quantum dots with different surface modifications

Energy Technology Data Exchange (ETDEWEB)

Valledor Llopis, Marta; Campo Rodriguez, Juan Carlos; Ferrero Martin, Francisco J [Departamento de Ingenieria Electrica, Electronica, C y S Universidad de Oviedo, Campus de Gijon s/n, 33204 Gijon, Asturias, (Spain); Coto, Ana Maria; Fernandez-Argueelles, Maria T; Costa-Fernandez, J M; Sanz-Medel, A [Departamento de Quimica Fisica y Analitica, Universidad de Oviedo, Campus del Cristo, 33006 Oviedo, Asturias (Spain)

2011-09-23

Photoinduced fluorescence enhancement of colloidal quantum dots (QDs) is a hot topic addressed in many studies due to its great influence on the bioanalytical performance of such nanoparticles. However, understanding of this process is not a simple task, and it cannot be explained by a general mechanism as it greatly depends on the QDs' nature, solubilization strategies, surrounding environment, etc. In this vein, we have critically compared the behavior of CdSe QDs (widely used in bioanalytical applications) with different surface modifications (ligand exchange and polymer coating), in different controlled experimental conditions, in the presence-absence of the ZnS layer and in different media when exposed for long times to intense UV irradiation. Thus six different types of colloidal QDs were finally studied. This research was carried out from a novel perspective, based on the analysis of the dynamic behavior of the photoactivation process (of great interest for further applications of QDs as labels in biomedical applications). The results showed a different behavior of the studied colloidal QDs after UV irradiation in terms of their photoluminescence characteristics, potential toxicity due to metal release to the environment, nanoparticle stability and surface coating degradation.

Dynamic analysis of the photoenhancement process of colloidal quantum dots with different surface modifications

International Nuclear Information System (INIS)

Valledor Llopis, Marta; Campo Rodriguez, Juan Carlos; Ferrero Martin, Francisco J; Coto, Ana Maria; Fernandez-Argueelles, Maria T; Costa-Fernandez, J M; Sanz-Medel, A

2011-01-01

Photoinduced fluorescence enhancement of colloidal quantum dots (QDs) is a hot topic addressed in many studies due to its great influence on the bioanalytical performance of such nanoparticles. However, understanding of this process is not a simple task, and it cannot be explained by a general mechanism as it greatly depends on the QDs' nature, solubilization strategies, surrounding environment, etc. In this vein, we have critically compared the behavior of CdSe QDs (widely used in bioanalytical applications) with different surface modifications (ligand exchange and polymer coating), in different controlled experimental conditions, in the presence-absence of the ZnS layer and in different media when exposed for long times to intense UV irradiation. Thus six different types of colloidal QDs were finally studied. This research was carried out from a novel perspective, based on the analysis of the dynamic behavior of the photoactivation process (of great interest for further applications of QDs as labels in biomedical applications). The results showed a different behavior of the studied colloidal QDs after UV irradiation in terms of their photoluminescence characteristics, potential toxicity due to metal release to the environment, nanoparticle stability and surface coating degradation.

Modifications at operating nuclear power plants

International Nuclear Information System (INIS)

Duffy, T.J.; Gazda, P.A.

1985-01-01

Modifications at operating nuclear power plants offer the structural engineer many challenges in the areas of scheduling of work, field adjustments, and engineering staff planning. The scheduling of structural modification work for operating nuclear power plants is normally closely tied to planned or unplanned outages of the plant. Coordination between the structural engineering effort, the operating plant staff, and the contractor who will be performing the modifications is essential to ensure that all work can be completed within the allotted time. Due to the inaccessibility of some areas in operating nuclear power plants or the short time available to perform the structural engineering in the case of an unscheduled outrage, field verification of a design is not always possible prior to initiating the construction of the modification. This requires the structural engineer to work closely with the contractor to promptly resolve problems due to unanticipated interferences or material procurement problems that may arise during the course of construction. The engineering staff planning for structural modifications at an operating nuclear power plant must be flexible enough to permit rapid response to the common ''fire drills,'' but controlled enough to ensure technically correct designs and to minimize the expenditure of man-hours and the resulting engineering cost

Theory Creation, Modification, and Testing: An Information-Processing Model and Theory of the Anticipated and Unanticipated Consequences of Research and Development

Science.gov (United States)

Perla, Rocco J.; Carifio, James

2011-01-01

Background: Extending Merton's (1936) work on the consequences of purposive social action, the model, theory and taxonomy outlined here incorporates and formalizes both anticipated and unanticipated research findings in a unified theoretical framework. The model of anticipated research findings was developed initially by Carifio (1975, 1977) and…

Residual Heat Removal System qualitative probabilistic safety analysis before and after auto closure interlock removal

International Nuclear Information System (INIS)

Mikulicic, V.; Simic, Z.

1992-01-01

The analysis evaluates the consequences of the removal of the auto closure interlock (ACI) on the Residual Heat Removal System (RHRS) suction/isolation valves at the nuclear power plant. The deletion of the RHRS ACI is in part based on a probabilistic safety analysis (PSA) which justifies the removal based on a criterion of increased availability and reliability. Three different areas to be examined in PSA: the likelihood of an interfacing system LOCA; RHRS availability and reliability; and low temperature overpressurization control. The paper emphasizes particularly the RHRS unavailability and reliability evaluation utilizing the current control circuitry configuration and then with the proposed modification to the control circuitry. (author)

Modification of ion chromatograph for analyses of radioactive samples

International Nuclear Information System (INIS)

Curfman, L.L.; Johnson, S.J.

1979-01-01

In ion chromatographic analysis, the sample is injected through a sample loop onto an analytical column where separation occurs. The sample then passes through a suppressor column to remove or neutralize background ions. A flow-through conductivity cell is used as a detector. Depending upon column and eluent selection, ion chromatography can be used for anion or cation analyses. Ion chromatography has proven to be a versatile analytical tool for the analysis of anions in Hanford waste samples. These radioactive samples range from caustic high salt solutions to hydrochloric acid dissolutions of insoluble sludges. Instrument modifications which provide safe and convenient handling of these samples without lengthening analysis time or altering instrument performance are described

Standard approach to plant modifications

International Nuclear Information System (INIS)

Mecredy, R.C.

1988-01-01

Organizational and management approaches to the design, installation, and turnover of nuclear plant modifications have changed dramatically in the last 10 to 15 yr. In response to these changes, organizational and individual responsibilities have been defined and management systems have been established at Rochester Gas and Electric (RG and E) Corporation to ensure that high-quality plant modifications are installed in a timely manner that satisfies user needs at minimal cost

Chemical modification of arginine residues in the lactose repressor

International Nuclear Information System (INIS)

Whitson, P.A.; Matthews, K.S.

1987-01-01

The lactose repressor protein was chemically modified with 2,3-butanedione and phenylglyoxal. Arginine reaction was quantitated by either amino aced analysis or incorporation of 14 C-labeled phenylglyoxal. Inducer binding activity was unaffected by the modification of arginine residues, while both operator and nonspecific DNA binding activities were diminished, although to differing degrees. The correlation of the decrease in DNA binding activities with the modification of ∼ 1-2 equiv of arginine per monomer suggests increased reactivity of a functionally essential residue(s). For both reagents, operator DNA binding activity was protected by the presence of calf thymus DNA, and the extent of reaction with phenylglyoxal was simultaneously diminished. This protection presumably results from steric restriction of reagent access to an arginine(s) that is (are) essential for DNA binding interactions. These experiments suggest that there is (are) an essential reactive arginine(s) critical for repressor binding to DNA

Boundary condition effect on response modification factor of X-braced steel frames

Directory of Open Access Journals (Sweden)

Walid A. Attia

2018-04-01

Full Text Available Design of the structures to resist seismic force depends on the theory of dissipation in elastic energy that already exists in response modification factor “R-factor”. The main problem in codes gives a constant value for R-factor, since change in boundary conditions of building change in behavior of braced steel frame structures and that effects on R-factor. This study is an attempt to assess overstrength, ductility and response modification factor of X-braced steel frame under change in boundary conditions, as change in the direction of strong axis of column and connection support type of column besides variation in storey and bays numbers to be 21 frames and each frame has 8 different boundary conditions as sum of 168 cases for analysis. These frames were analyzed by using nonlinear static “pushover” analysis. As results of this study change in support type and direction of strong axis of column give large change in value of R-factor; the minimum value was 4.37 and maximum value 10.97. Minimum value is close to code value that’s mean the code is more conservative in suggesting of R-factor and gives a large factor of safety. Change in the location of bracing gives change in value of R-factor for all boundary conditions. Change in direction of strong axis of columns and support type didn’t give change in value of fundamental period, all boundary conditions. Keywords: Response modification factor, Ductility reduction factor, Overstrength factor, Boundary conditions, Brace frame, Nonlinear static analysis “Pushover”

Oxidation of Proteins in Plants-Mechanisms and Consequences

DEFF Research Database (Denmark)

Sweetlove, Lee J; Møller, Ian M

2009-01-01

The production of reactive oxygen and reactive nitrogen species in plant cells can lead to a variety of modifications of proteins through oxidation of amino acid side groups. The widespread occurrence of such modifications is becoming appreciated as new proteomic approaches allow their systematic....... A view that such modifications could have signalling ramifications is emerging. However, in many cases there is a lack of information as to the effect of oxidation on protein activity or function. Severe protein oxidation is costly to the cell since oxidatively damaged proteins need to be degraded...... of modified proteins by affinity purification. Although there are several technical caveats with such approaches, they have been useful in documenting the extent of oxidative modification of proteins and have highlighted a number of proteins where oxidative modification is critical for protein function...

Identifying controlling variables for math computation fluency through experimental analysis: the interaction of stimulus control and reinforcing consequences.

Science.gov (United States)

Hofstadter-Duke, Kristi L; Daly, Edward J

2015-03-01

This study investigated a method for conducting experimental analyses of academic responding. In the experimental analyses, academic responding (math computation), rather than problem behavior, was reinforced across conditions. Two separate experimental analyses (one with fluent math computation problems and one with non-fluent math computation problems) were conducted with three elementary school children using identical contingencies while math computation rate was measured. Results indicate that the experimental analysis with non-fluent problems produced undifferentiated responding across participants; however, differentiated responding was achieved for all participants in the experimental analysis with fluent problems. A subsequent comparison of the single-most effective condition from the experimental analyses replicated the findings with novel computation problems. Results are discussed in terms of the critical role of stimulus control in identifying controlling consequences for academic deficits, and recommendations for future research refining and extending experimental analysis to academic responding are made. © The Author(s) 2014.

Efficient reanalysis of structures by a direct modification method. [local stiffness modifications of large structures

Science.gov (United States)

Raibstein, A. I.; Kalev, I.; Pipano, A.

1976-01-01

A procedure for the local stiffness modifications of large structures is described. It enables structural modifications without an a priori definition of the changes in the original structure and without loss of efficiency due to multiple loading conditions. The solution procedure, implemented in NASTRAN, involved the decomposed stiffness matrix and the displacement vectors of the original structure. It solves the modified structure exactly, irrespective of the magnitude of the stiffness changes. In order to investigate the efficiency of the present procedure and to test its applicability within a design environment, several real and large structures were solved. The results of the efficiency studies indicate that the break-even point of the procedure varies between 8% and 60% stiffness modifications, depending upon the structure's characteristics and the options employed.

Body piercing with fatal consequences.

Science.gov (United States)

Ranga, N; Jeffery, A J

2011-01-25

Body modifications such as piercings, tattoos and surgery have increased in popularity in recent times and have become more socially acceptable. The common complications of piercing different parts of the human anatomy are well-documented, including sepsis, allergic reactions and, more rarely, endocarditis and ischaemia. Deaths related to piercing complications are primarily septic in origin. In this case, a man in his 50s died due to complications of his multiple umbilical piercings. The cause of death was unusually linked to body modification; the umbilical piercings had ultimately led to a mesenteric infarction. Cases such as these are forensically important due to potential manslaughter charges that could be brought against a piercing establishment. More importantly, this case highlights another extreme complication of body modification. Fashion statements are always changing and impact upon many lives. It is important to highlight to people the potentially life-threatening complications of common piercing practices.

The computational nature of memory modification

Science.gov (United States)

Gershman, Samuel J; Monfils, Marie-H; Norman, Kenneth A; Niv, Yael

2017-01-01

Retrieving a memory can modify its influence on subsequent behavior. We develop a computational theory of memory modification, according to which modification of a memory trace occurs through classical associative learning, but which memory trace is eligible for modification depends on a structure learning mechanism that discovers the units of association by segmenting the stream of experience into statistically distinct clusters (latent causes). New memories are formed when the structure learning mechanism infers that a new latent cause underlies current sensory observations. By the same token, old memories are modified when old and new sensory observations are inferred to have been generated by the same latent cause. We derive this framework from probabilistic principles, and present a computational implementation. Simulations demonstrate that our model can reproduce the major experimental findings from studies of memory modification in the Pavlovian conditioning literature. DOI: http://dx.doi.org/10.7554/eLife.23763.001 PMID:28294944

23 CFR 630.110 - Modification of original agreement.

Science.gov (United States)

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Modification of original agreement. 630.110 Section 630... OPERATIONS PRECONSTRUCTION PROCEDURES Project Authorization and Agreements § 630.110 Modification of original agreement. (a) When changes are needed to the original project agreement, a modification of agreement shall...

Vacuum-based surface modification of organic and metallic substrates

Science.gov (United States)

Torres, Jessica

Surface physico-chemical properties play an important role in the development and performance of materials in different applications. Consequently, understanding the chemical and physical processes involved during surface modification strategies is of great scientific and technological importance. This dissertation presents results from the surface modification of polymers, organic films and metallic substrates with reactive species, with the intent of simulating important modification processes and elucidating surface property changes of materials under different environments. The reactions of thermally evaporated copper and titanium with halogenated polytetrafluoroethylene (PTFE) and polyvinyl chloride (PVC) are used to contrast the interaction of metals with polymers. Results indicate that reactive metallization is thermodynamically favored when the metal-halogen bond strength is greater than the carbon-halogen bond strength. X-ray post-metallization treatment results in an increase in metal-halide bond formation due to the production of volatile halogen species in the polymer that react with the metallic overlayer. The reactions of atomic oxygen (AO) and atomic chlorine with polyethylene (PE) and self-assembled monolayers (SAMs) films were followed to ascertain the role of radical species during plasma-induced polymer surface modification. The reactions of AO with X-ray modified SAMs are initially the dominated by the incorporation of new oxygen containing functionality at the vacuum/film interface, leading to the production of volatile carbon containing species such as CO2 that erodes the hydrocarbon film. The reaction of atomic chlorine species with hydrocarbon SAMs, reveals that chlorination introduces C-Cl and C-Cl2 functionalities without erosion. A comparison of the reactions of AO and atomic chlorine with PE reveal a maximum incorporation of the corresponding C-O and C-Cl functionalities at the polymer surface. A novel method to prepare phosphorous

Surface modification of ceramics. Ceramics no hyomen kaishitsu

Energy Technology Data Exchange (ETDEWEB)

Hioki, T. (Toyota Central Research and Development Labs., Inc., Nagoya (Japan))

1993-07-05

Surface modification of ceramics and some study results using in implantation in surface modification are introduced. The mechanical properties (strength, fracture toughness, flaw resistance) of ceramics was improved and crack was repaired using surface modification by ion implantation. It is predicted that friction and wear properties are considerably affected because the hardness of ceramics is changed by ion implantation. Cementing and metalization are effective as methods for interface modification and the improvement of the adhesion power of the interface between metal and ceramic is their example. It was revealed that the improvement of mechanical properties of ceramics was achieved if appropriate surface modification was carried out. The market of ceramics mechanical parts is still small, therefore, the present situation is that the field of activities for surface modification of ceramics is also narrow. However, it is thought that in future, ceramics use may be promoted surely in the field like medicine and mechatronics. 8 refs., 4 figs.

DNA methylation modifications associated with chronic fatigue syndrome.

Directory of Open Access Journals (Sweden)

Wilfred C de Vega

Full Text Available Chronic Fatigue Syndrome (CFS, also known as myalgic encephalomyelitis, is a complex multifactorial disease that is characterized by the persistent presence of fatigue and other particular symptoms for a minimum of 6 months. Symptoms fail to dissipate after sufficient rest and have major effects on the daily functioning of CFS sufferers. CFS is a multi-system disease with a heterogeneous patient population showing a wide variety of functional disabilities and its biological basis remains poorly understood. Stable alterations in gene function in the immune system have been reported in several studies of CFS. Epigenetic modifications have been implicated in long-term effects on gene function, however, to our knowledge, genome-wide epigenetic modifications associated with CFS have not been explored. We examined the DNA methylome in peripheral blood mononuclear cells isolated from CFS patients and healthy controls using the Illumina HumanMethylation450 BeadChip array, controlling for invariant probes and probes overlapping polymorphic sequences. Gene ontology (GO and network analysis of differentially methylated genes was performed to determine potential biological pathways showing changes in DNA methylation in CFS. We found an increased abundance of differentially methylated genes related to the immune response, cellular metabolism, and kinase activity. Genes associated with immune cell regulation, the largest coordinated enrichment of differentially methylated pathways, showed hypomethylation within promoters and other gene regulatory elements in CFS. These data are consistent with evidence of multisystem dysregulation in CFS and implicate the involvement of DNA modifications in CFS pathology.

Nanosecond laser surface modification of AISI 304L stainless steel: Influence the beam overlap on pitting corrosion resistance

International Nuclear Information System (INIS)

Pacquentin, Wilfried; Caron, Nadège; Oltra, Roland

2014-01-01

Surface modifications of AISI 304L stainless steel by laser surface melting (LSM) were investigated using a nanosecond pulsed laser-fibre doped by ytterbium at different overlaps. The objective was to study the change in the corrosion properties induced by the treatment of the outer-surface of the stainless steel without modification of the bulk material. Different analytical techniques such as scanning electron microscopy (SEM), X-ray diffraction (XRD), and glow discharge optical emission spectrometry (GDOES) were used to characterize the laser-melted surface. The corrosion resistance was evaluated in a chloride solution at room temperature by electrochemical tests. The results showed that the crystallographic structure, the chemical composition, the properties of the induced oxide layer and consequently the pitting corrosion resistance strongly depend on the overlap rate. The most efficient laser parameters led to an increase of the pitting potential by more than 300 mV, corresponding to a quite important improvement of the corrosion resistance. This latter was correlated to chromium enrichment (47 wt.%) at the surface of the stainless steel and the induced absence of martensite and ferrite phases. However, these structural and chemical modifications were not sufficient to explain the change in corrosion behaviour: defects and adhesion of the surface oxide layer must have been taken into consideration.

Confusing procedures with process when appraising the impact of cognitive bias modification on emotional vulnerability

NARCIS (Netherlands)

Grafton, B.; MacLeod, C.; Rudaizky, D.; Holmes, E.A.; Salemink, E.; Fox, E.; Notebaert, L.

2017-01-01

If meta-analysis is to provide valuable answers, then it is critical to ensure clarity about the questions being asked. Here, we distinguish two important questions concerning cognitive bias modification research that are not differentiated in the meta-analysis recently published by Cristea et al

Variations of Histone Modification Patterns: Contributions of Inter-plant Variability and Technical Factors

Directory of Open Access Journals (Sweden)

Sylva Brabencová

2017-12-01

Full Text Available Inter-individual variability of conspecific plants is governed by differences in their genetically determined growth and development traits, environmental conditions, and adaptive responses under epigenetic control involving histone post-translational modifications. The apparent variability in histone modifications among plants might be increased by technical variation introduced in sample processing during epigenetic analyses. Thus, to detect true variations in epigenetic histone patterns associated with given factors, the basal variability among samples that is not associated with them must be estimated. To improve knowledge of relative contribution of biological and technical variation, mass spectrometry was used to examine histone modification patterns (acetylation and methylation among Arabidopsis thaliana plants of ecotypes Columbia 0 (Col-0 and Wassilewskija (Ws homogenized by two techniques (grinding in a cryomill or with a mortar and pestle. We found little difference in histone modification profiles between the ecotypes. However, in comparison of the biological and technical components of variability, we found consistently higher inter-individual variability in histone mark levels among Ws plants than among Col-0 plants (grown from seeds collected either from single plants or sets of plants. Thus, more replicates of Ws would be needed for rigorous analysis of epigenetic marks. Regarding technical variability, the cryomill introduced detectably more heterogeneity in the data than the mortar and pestle treatment, but mass spectrometric analyses had minor apparent effects. Our study shows that it is essential to consider inter-sample variance and estimate suitable numbers of biological replicates for statistical analysis for each studied organism when investigating changes in epigenetic histone profiles.

Variations of Histone Modification Patterns: Contributions of Inter-plant Variability and Technical Factors.

Science.gov (United States)

Brabencová, Sylva; Ihnatová, Ivana; Potěšil, David; Fojtová, Miloslava; Fajkus, Jiří; Zdráhal, Zbyněk; Lochmanová, Gabriela

2017-01-01

Inter-individual variability of conspecific plants is governed by differences in their genetically determined growth and development traits, environmental conditions, and adaptive responses under epigenetic control involving histone post-translational modifications. The apparent variability in histone modifications among plants might be increased by technical variation introduced in sample processing during epigenetic analyses. Thus, to detect true variations in epigenetic histone patterns associated with given factors, the basal variability among samples that is not associated with them must be estimated. To improve knowledge of relative contribution of biological and technical variation, mass spectrometry was used to examine histone modification patterns (acetylation and methylation) among Arabidopsis thaliana plants of ecotypes Columbia 0 (Col-0) and Wassilewskija (Ws) homogenized by two techniques (grinding in a cryomill or with a mortar and pestle). We found little difference in histone modification profiles between the ecotypes. However, in comparison of the biological and technical components of variability, we found consistently higher inter-individual variability in histone mark levels among Ws plants than among Col-0 plants (grown from seeds collected either from single plants or sets of plants). Thus, more replicates of Ws would be needed for rigorous analysis of epigenetic marks. Regarding technical variability, the cryomill introduced detectably more heterogeneity in the data than the mortar and pestle treatment, but mass spectrometric analyses had minor apparent effects. Our study shows that it is essential to consider inter-sample variance and estimate suitable numbers of biological replicates for statistical analysis for each studied organism when investigating changes in epigenetic histone profiles.