WorldWideScience

Sample records for confirmation des priorits

  1. Confirming, Classifying, and Prioritizing Needed Over-the-Bed Table Improvements via Methodological Triangulation.

    Science.gov (United States)

    Manganelli, Joe; Threatt, Anthony; Brooks, Johnell O; Healy, Stan; Merino, Jessica; Yanik, Paul; Walker, Ian; Green, Keith

    2014-01-01

    This article presents the results of a qualitative study that confirmed, classified, and prioritized user needs for the design of a more useful, usable, and actively assistive over-the-bed table. Manganelli et al. (2014) generated a list of 74 needs for use in developing an actively assistive over-the-bed table. This present study assesses the value and importance of those needs. Fourteen healthcare subject matter experts and eight research and design subject matter experts engaged in a participatory and iterative research and design process. A mixed methods qualitative approach used methodological triangulation to confirm the value of the findings and ratings to establish importance. Open and closed card sorts and a Delphi study were used. Data analysis methods included frequency analysis, content analysis, and a modified Kano analysis. A table demonstrating the needs that are of high importance to both groups of subject matter experts and classification of the design challenges each represents was produced. Through this process, the list of 74 needs was refined to the 37 most important need statements for both groups. Designing a more useful, usable, and actively assistive over-the-bed table is primarily about the ability to position it optimally with respect to the user for any task, as well as improving ease of use and usability. It is also important to make explicit and discuss the differences in priorities and perspectives demonstrated between research and design teams and their clients. © 2014 Vendome Group, LLC.

  2. Des membres du PS, de la LCR et du PCF reunis par le "non" a la Constitution (reunion sous l'egide de la Fondation Copernic mardi 19 octobre 2004 a la Maison des metallurgistes a Paris - referendum sur la constitution) Pour le chef de l'Etat, a Geneve, le 19 octobre, c'est "plus qu'une priorite"

    CERN Document Server

    Beatrice, G

    2004-01-01

    Des membres du PS, de la LCR et du PCF reunis par le "non" a la Constitution (reunion sous l'egide de la Fondation Copernic mardi 19 octobre 2004 a la Maison des metallurgistes a Paris - referendum sur la constitution) Pour le chef de l'Etat, a Geneve, le 19 octobre, c'est "plus qu'une priorite"

  3. Diversité, priorité pastorale et de conservation des ligneux fourragers des terres de parcours en zone soudano-guinéenne du Bénin

    Directory of Open Access Journals (Sweden)

    Sèwadé, C.

    2016-01-01

    Full Text Available Diversity, pastoral and conservation priorities of fodder trees in the Sudano-Guinean pasture lands of Benin. Description of the subject. Fodder trees are important for livestock survival in dryland Africa. In view of the pressure faced by these trees, and their consequent rarity noted in rangelands, a study was conducted in the Sudano-Guinean transition zone of Benin at the level of the local population surrounding the protected forests of Monts Kouffé, Wari-Maro and Ouémé Supérieur. Objectives. This study aimed to inventory the fodder trees, analyze the local perception of factors threatening target fodder trees, according to different sociolinguistic groups and prioritize fodder trees for conservation. Method. Ethnobiological surveys and ecological data from the available literature were used to construct a database following different criteria. The citation rates of the fodder trees by the surveyed populations were used to establish pastoral priority, while their conservation priority was established using a combination of four methods and nine criteria. Results. Forty-eight fodder trees belonging to 17 families dominated by Leguminosae (27.1% and Moraceae (16.6% were reported. These species were distributed among 37 genera, with the genus Ficus being the most represented (16.6%. Palatability, species availability and the impact of tree fodder on animal productivity were the criteria used by the surveyed sociolinguistic groups in their selection of fodder trees. The prioritization methods yielded ten top ranked species: Afzelia africana, Pterocarpus erinaceus, Khaya senegalensis, Vitellaria paradoxa, Mangifera indica, Ficus platyphylla, Balanites aegyptiaca, Annona senegalensis, Ficus umbellata and Daniellia oliveri. Conclusions. With the aim of establishing the sustainable management of pasture lands, we suggest that priority be given to the aforementioned species of fodder trees as part of restoration, afforestation/reforestation and

  4. Retrospective study on sero-epidemiology of peste des petits ruminants before its official confirmation in northern Tanzania in 2008

    Directory of Open Access Journals (Sweden)

    E.D. Karimuribo,

    2011-03-01

    Full Text Available A retrospective sero-epidemiological investigation of Peste des petits ruminants (PPR was carried out in Ngorongoro district, situated in northern part of Tanzania and bordering Kenya. The study involved collection of field information from 101 respondents who own goats and sheep in four villages which had experienced a ‘rinderpest-like’ syndrome in domestic small ruminants between first suspected cases of PPR in 1995 and official confirmation of the disease in Tanzania in 2008. A total number of 198 serum samples from goats and sheep collected in 1998 and 2004 for different research projects or suspected disease investigation were retrieved from the Veterinary Investigation centre (VIC Arusha and subjected to competitive ELISA test for detecting antibodies to PPR virus. Findings of this study suggest that PPR was in northern Tanzania at least four years before official confirmation and reporting based on clinico-pathological grounds, local field-based reports from livestock field officers and District Veterinary Officer. The seroprevalence of PPR from 198 serum samples analysed was 12.6% with the serum samples collected from suspected PPR cases showing significantly (p=0.000 higher seroprevalence (71.4% than that in samples collected for investigation of other diseases (5.7%. Interviewed farmers were aware of PPR including clear description of clinical signs of the disease. Although farmers were aware of efforts made to control the disease, only 32% of them had their animals vaccinated against PPR. The low vaccination coverage suggests continued prevalence of PPR in the study area. It is concluded that there is limited capacity with respect to veterinary disease surveillance, reporting and control of transboundary and emerging diseases which need to be addressed in the country.

  5. IT Project Prioritization Process

    DEFF Research Database (Denmark)

    Shollo, Arisa; Constantiou, Ioanna

    2013-01-01

    In most of the large companies IT project prioritization process is designed based on principles of evidencebased management. We investigate a case of IT project prioritization in a financial institution, and in particular, how managers practice evidence-based management during this process. We use...... a rich dataset built from a longitudinal study of the prioritization process for the IT projects. Our findings indicate that managers reach a decision not only by using evidence but from the interplay between the evidence and the judgment devices that managers employ. The interplay between evidence...... and judgment devices is manifested in three ways: supplementing, substituting, and interpreting evidence. We show that while evidence does not fully determine the decision, it plays a central role in discussions, reflections, and negotiations during the IT prioritization process....

  6. NWRS Survey Prioritization Tool

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — A SMART Tool and User's Guide for aiding NWRS Station staff when prioritizing their surveys for an Inventory and Monitoring Plan. This guide describes a process and...

  7. Evidence of peste des petits ruminants virus (PPRV) infection in Sindh Ibex (Capra aegagrus blythi) in Pakistan as confirmed by detection of antigen and antibody.

    Science.gov (United States)

    Abubakar, Muhammad; Rajput, Zahid Iqbal; Arshed, Muhammad Javed; Sarwar, Ghulam; Ali, Qurban

    2011-04-01

    An outbreak resulting in mortality in Sindh Ibex (Capra aegagrus blythi) was investigated. There was a history of about 36 deaths (both young and adult) during the period of 1 month. Disease appeared in a generalized form, affecting the respiratory and digestive systems. Major lesions were respiratory distress, pustules on and in the mouth, ocular-nasal discharges, and severe diarrhea. The most significant lesion was the oculonasal discharges and diarrhea. Deaths were mainly due to blindness, anorexia, diarrhea, and respiratory arrest. Both adult (mortality = 21) and young (mortality = 15) animals were affected with the disease. Peste des petits ruminants virus (PPRV) antigen was detected in the spleen, lung, lymph node, and swab samples by immunocapture enzyme-linked immunosorbent assay. Spleen and lung samples were also tested and found positive for the presence of F-gene of PPRV by polymerase chain reaction. Thirteen of 20 serum samples from nearby sheep and goats were found positive for antibodies to PPRV. The disease threatened the huge population of ibex in the wild life park, which was spread over a large area, but vaccination of the domestic population of sheep and goats in the surrounding villages appeared to control the disease.

  8. Prioritized Experience Replay

    OpenAIRE

    Schaul, Tom; Quan, John; Antonoglou, Ioannis; Silver, David

    2015-01-01

    Experience replay lets online reinforcement learning agents remember and reuse experiences from the past. In prior work, experience transitions were uniformly sampled from a replay memory. However, this approach simply replays transitions at the same frequency that they were originally experienced, regardless of their significance. In this paper we develop a framework for prioritizing experience, so as to replay important transitions more frequently, and therefore learn more efficiently. We u...

  9. Prioritized Abduction with CHR

    DEFF Research Database (Denmark)

    Christiansen, Henning

    2008-01-01

    A class of Prioritized Abductive Logic Programs (PrioALPs) is introduced and an implementation is developed in CHR for solving abductive problems, providing minimal explanations with best-first search. Priorities may represent probabilities or a cost function to be optimized. Compared with other...... weighted and probabilistic versions of abductive logic programming, the approach is characterized by higher generality and a flexible and adaptable architecture which incorporates integrity constraints and interaction with external constraint solvers. A PrioALP is translated in a systematic way into a CHR...

  10. Retour vers le futur: l'expérience des patients et le lien avec la qualité, la sécurité et le rendement financier.

    Science.gov (United States)

    Cochrane, Bonnie S; Hagins, Mitch; King, John A; Picciano, Gino; McCafferty, Maureen M; Nelson, Brian

    2015-11-01

    Au Canada, l'amélioration de l'expérience des patients est devenue une priorité des politiques de santé. Le perfectionnement et la normalisation des outils et systèmes pour surveiller les mesures de l'expérience des patients augmentent, tandis que la tendance vers une plus grande reddition de compte sur des améliorations durables et abordables se confirme. Pour de nombreux professionnels de la santé, ce phénomène fait foi d'un intérêt renouvelé pour les besoins et priorités fondamentaux des patients, après des décennies où les changements structurels et technologiques ont dominé les programmes de santé. Pour les leaders en santé canadiens, l'amélioration de l'expérience des patients comporte actuellement de grands défis et de belles possibilités. À cet égard, l'expérience des organisations partenaires du groupe Studer au Canada est à la fois pertinente et instructive. Ces organisations ont adopté un modèle, du nom de Evidence-Based Leadership (EBL, ou leadership fondé sur des données probantes), qui favorise et soutient l'harmonisation de l'ensemble des activités et des comportements, conformément à des objectifs organisationnels précis, y compris des améliorations mesurables de l'expérience des patients. Le présent article expose des études de cas d'organisations qui ont adopté l'EBL. Ces organisations ont réalisé des progrès rapides en matière d'indicateurs de l'expérience des patients, ainsi que dans des secteurs essentiels comme les résultats cliniques, la sécurité et le rendement financier. Les données émergentes sur les facteurs et processus qui sous-tendent ces améliorations sont également abordées.

  11. Prioritized Contact Transport Stream

    Science.gov (United States)

    Hunt, Walter Lee, Jr. (Inventor)

    2015-01-01

    A detection process, contact recognition process, classification process, and identification process are applied to raw sensor data to produce an identified contact record set containing one or more identified contact records. A prioritization process is applied to the identified contact record set to assign a contact priority to each contact record in the identified contact record set. Data are removed from the contact records in the identified contact record set based on the contact priorities assigned to those contact records. A first contact stream is produced from the resulting contact records. The first contact stream is streamed in a contact transport stream. The contact transport stream may include and stream additional contact streams. The contact transport stream may be varied dynamically over time based on parameters such as available bandwidth, contact priority, presence/absence of contacts, system state, and configuration parameters.

  12. Repository performance confirmation.

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, Francis D.

    2011-09-01

    of the Yucca Mountain license application identified a broad suite of monitoring activities. A revision of the plan was expected to winnow the number of activities down to a manageable size. As a result, an objective process for the next stage of performance confirmation planning was developed as an integral part of an overarching long-term testing and monitoring strategy. The Waste Isolation Pilot Plant compliance monitoring program at once reflects its importance to stakeholders while demonstrating adequate understanding of relevant monitoring parameters. The compliance criteria were stated by regulation and are currently monitored as part of the regulatory rule for disposal. At the outset, the screening practice and parameter selection were not predicated on a direct or indirect correlation to system performance metrics, as was the case for Yucca Mountain. Later on, correlation to performance was established, and the Waste Isolation Pilot Plant continues to monitor ten parameters originally identified in the compliance certification documentation. The monitoring program has proven to be effective for the technical intentions and societal or public assurance. The experience with performance confirmation in the license application process for Yucca Mountain helped identify an objective, quantitative methodology for this purpose. Revision of the existing plan would be based on findings of the total system performance assessment. Identification and prioritization of confirmation activities would then derive from performance metrics associated with performance assessment. Given the understanding of repository performance confirmation, as reviewed in this paper, it is evident that the performance confirmation program for the Yucca Mountain project could be readily re-engaged if licensing activities resumed.

  13. Prioritizing like nuclear smugglers

    Energy Technology Data Exchange (ETDEWEB)

    Erickson, S A

    1999-07-01

    An individual or group attempting to smuggle nuclear material out of a country has a choice of what border crossing to use and how to do it. If it is possible to think like a smuggler and determine what preferences one would have, then we could protect those smuggler-preferred border crossings first. Thinking like a smuggler requires that one understand a host of things: who is likely to smuggle and what might they have obtained, where they might have gotten it, and where they would like to deliver or sell it, how they will attempt to pass customs, how they might travel on both sides of the border, and what influences they might have on customs officials. After collecting data on criminology, geography, and much else, it is necessary to paste the data together into scenarios to ensure that self-consistent smuggling plans are created. These lead to counter-smuggling opportunities. Smuggling by amateurs turns out to be of a different class than professional smuggling, and needs to be countered differently. This work also assists in formulating key policy questions useful to guide counter-smuggling efforts. This methodology was developed for DOE/NN-43 for assistance with prioritization within the Second Line of Defense program.

  14. Patient Prioritization Preferences among Physiotherapy Entry-Level Students: The Importance of Chronic Pain.

    Science.gov (United States)

    Laliberté, Maude; Ehrmann Feldman, Debbie

    2013-01-01

    Objectif : Étudier les préférences des étudiants en physiothérapie au niveau débutant sur le plan de l'attribution d'une priorité aux patients, en particulier aux patients vivant avec une douleur chronique. Méthode: Après une discussion en groupe, 249 étudiants canadiens en physiothérapie au niveau débutant ont rempli un questionnaire basé sur cinq scénarios distincts (cas de patients fictifs). On a demandé aux répondants d'attribuer une priorité aux patients (P1=priorité la plus élevée, P5=priorité la plus basse). Résultats : Les étudiants en physiothérapie ont accordé la priorité la plus élevée aux patients vivant avec de la douleur chronique et aux patients qui venaient de subir une intervention chirurgicale. Le patient âgé et le patient qui avait un déficit cognitif ont reçu une priorité plus basse. Conclusions : Les étudiants en physiothérapie accordent la plus grande priorité à un diagnostic de douleur chronique. Les publications montrent toutefois que la douleur chronique constitue la priorité la plus basse dans les outils de triage des départements de physiothérapie. Il pourrait y avoir un virage au niveau des préférences entre la période qui précède la pratique (étudiants) et celle qui la suit (clinicien) en ce qui a trait aux patients vivant avec une douleur chronique.

  15. Savannah River Site prioritization of transition activities

    Energy Technology Data Exchange (ETDEWEB)

    Finley, R.H.

    1993-11-01

    Effective management of SRS conversion from primarily a production facility to other missions (or Decontamination and Decommissioning (D&D)) requires a systematic and consistent method of prioritizing the transition activities. This report discusses the design of a prioritizing method developed to achieve systematic and consistent methods of prioritizing these activities.

  16. Place prioritization for biodiversity content

    Indian Academy of Sciences (India)

    Sahotra Sarkar; Anshu Aggarwal; Justin Garson; Chris R Margules; Juliane Zeidler

    2002-07-01

    The prioritization of places on the basis of biodiversity content is part of any systematic biodiversity conservation planning process. The place prioritization procedure implemented in the ResNet software package is described. This procedure is primarily based on the principles of rarity and complementarity. Application of the procedure is demonstrated with two analyses, one data set consisting of the distributions of termite genera in Namibia, and the other consisting of the distributions of bird species in the Islas Malvinas/Falkland Islands. The attributes that data sets should have for the effective and reliable application of such procedures are discussed. The procedure used here is compared to some others that are also currently in use.

  17. Architecture-driven requirements prioritization

    OpenAIRE

    2012-01-01

    Quality requirements are main drivers for architectural decisions of software systems. However, in practice they are often dismissed during development, because of initially unknown dependencies and consequences that complicate implementation. To decide for meaningful, feasible quality requirements and trade them off with functional requirements, tighter integration of software architecture evaluation and requirements prioritization is necessary. In this position paper, we propose a tool-supp...

  18. Candidate gene prioritization with Endeavour.

    Science.gov (United States)

    Tranchevent, Léon-Charles; Ardeshirdavani, Amin; ElShal, Sarah; Alcaide, Daniel; Aerts, Jan; Auboeuf, Didier; Moreau, Yves

    2016-07-08

    Genomic studies and high-throughput experiments often produce large lists of candidate genes among which only a small fraction are truly relevant to the disease, phenotype or biological process of interest. Gene prioritization tackles this problem by ranking candidate genes by profiling candidates across multiple genomic data sources and integrating this heterogeneous information into a global ranking. We describe an extended version of our gene prioritization method, Endeavour, now available for six species and integrating 75 data sources. The performance (Area Under the Curve) of Endeavour on cross-validation benchmarks using 'gold standard' gene sets varies from 88% (for human phenotypes) to 95% (for worm gene function). In addition, we have also validated our approach using a time-stamped benchmark derived from the Human Phenotype Ontology, which provides a setting close to prospective validation. With this benchmark, using 3854 novel gene-phenotype associations, we observe a performance of 82%. Altogether, our results indicate that this extended version of Endeavour efficiently prioritizes candidate genes. The Endeavour web server is freely available at https://endeavour.esat.kuleuven.be/.

  19. Throughput centered prioritization of machines in transfer lines

    Energy Technology Data Exchange (ETDEWEB)

    Pascual, R., E-mail: rpascual@ing.puc.cl [Physical Asset Management Lab, Centro de Mineria, Pontificia Universidad Catolica de Chile, Av. Vicuna Mackenna 4860, Santiago (Chile); Godoy, D. [Physical Asset Management Lab, Centro de Mineria, Pontificia Universidad Catolica de Chile, Av. Vicuna Mackenna 4860, Santiago (Chile); Louit, D.M. [Komatsu Chile S.A., Av. Americo Vespucio 0631, Quilicura, Santiago (Chile)

    2011-10-15

    In an environment of scarce resources and complex production systems, prioritizing is key to confront the challenge of managing physical assets. In the literature, there exist a number of techniques to prioritize maintenance decisions that consider safety, technical and business perspectives. However, the effect of risk mitigating elements-such as intermediate buffers in production lines-on prioritization has not yet been investigated in depth. In this line, the work proposes a user-friendly graphical technique called the system efficiency influence diagram (SEID). Asset managers may use SEID to identify machines that have a greater impact on the system throughput, and thus set prioritized maintenance policies and/or redesign of buffers capacities. The tool provides insight to the analyst as it decomposes the influence of a given machine on the system throughput as a product of two elements: (1) system influence efficiency factor and (2) machine unavailability factor. We illustrate its applicability using three case studies: a four-machine transfer line, a vehicle assembly line, and an open-pit mining conveyor system. The results confirm that the machines with greater unavailability factors are not necessarily the most important for the efficiency of the production line, as it is the case when no intermediate buffers exist. As a decision aid tool, SEID emphasizes the need to move from a maintenance vision focused on machine availability, to a systems engineering perspective. - Highlights: > We propose a graphical technique to prioritize machines in production lines. > The tool is called 'system efficiency influence diagram' (SEID). > It helps setting prioritized maintenance policies and/or redesign of buffers. > The SEID technique focuses on system efficiency and throughput. > We illustrate its applicability using three case studies.

  20. Prioritization methodology for chemical replacement

    Science.gov (United States)

    Goldberg, Ben; Cruit, Wendy; Schutzenhofer, Scott

    1995-01-01

    This methodology serves to define a system for effective prioritization of efforts required to develop replacement technologies mandated by imposed and forecast legislation. The methodology used is a semi quantitative approach derived from quality function deployment techniques (QFD Matrix). QFD is a conceptual map that provides a method of transforming customer wants and needs into quantitative engineering terms. This methodology aims to weight the full environmental, cost, safety, reliability, and programmatic implications of replacement technology development to allow appropriate identification of viable candidates and programmatic alternatives.

  1. Army Reserve Capabilities-Based Prioritization Study

    Science.gov (United States)

    2008-08-15

    journal databases such as JSTOR , ABI Inform, Proquest, and Emerald; syllabi for courses in strategic management and planning at Harvard, MIT, Wharton, and...methodology for prioritization. • Secure, database repository of appropriate bins, criteria or metrics for prioritization. • Reproducible...Prioritization PPBC/SRG Initial POM Database turned over to Army Budget TGM Issued ARB Final POM/BES Decisions Price/Rate Changes Other Fact-of-Life Changes

  2. Problem Prioritization in Usability Evaluation:

    DEFF Research Database (Denmark)

    Hertzum, Morten

    2006-01-01

    Severity assessments enable prioritization of problems encountered during usability evaluations and thereby provide a device for guiding the utilization of design resources. However, designers' response to usability evaluations is also influenced by other factors, which may overshadow severity....... With the purpose of enhancing the impact of severity assessments, this study combines a field study of factors that influence the impact of evaluations with an experimental study of severity assessments made during usability inspections. The results show that even in a project receptive to input from evaluations...... their impact was highly dependent on conducting evaluations early. This accorded with an informal method that blended elements of usability evaluation and participatory design and could be extended with user-made severity assessments. The major cost associated with the evaluations was not finding but fixing...

  3. Prioritizing obesity in the city.

    Science.gov (United States)

    Dean, Jennifer Asanin; Elliott, Susan J

    2012-02-01

    A decade ago, the World Health Organization declared obesity to be a global epidemic. Accordingly, there is a growing body of research examining how "obesogenic environments" contribute to the increasing prevalence of obesity. Using the ANGELO Framework, this research explores the role of municipal policies and practices in constructing obesogenic environments in two Southern Ontario cities in order to examine how socio-cultural and political environments shape excess body weight. Data was collected from municipal policy documents, public health websites, and key informants in Hamilton and Mississauga, Ontario, Canada. Results indicate that while the cities took different approaches to dealing with obesity, they both reflected the cities' overall prioritizing of health. Additionally, the findings reveal the pervasiveness of values and attitudes held in the socio-cultural environment in further shaping (and being shaped by) political as well as economic and physical environments in the cities. The importance of explicitly acknowledging the official discourse of the city, which this study demonstrates to be a significant factor in constructing obesogenic environments, is highlighted. Theoretical contributions and policy implications are also discussed.

  4. Attentes en matière d’élevage des acteurs de la sélection animale, des filières de l’agroalimentaire et des associations

    OpenAIRE

    Dockès, A.C.; Magdelaine, P.; DARIDAN, D.; Guillaumin, A.; Rémondet, Martin; Selmi, Adel; Gilbert, Hélène; Grasteau, Sandrine; Phocas, Florence

    2011-01-01

    Le projet COSADD a été conduit de 2007 à 2009 pour identifier, tester des objectifs de sélection animale compatibles avec une perspective de développement durable, et cohérents avec les attentes des acteurs concernés. Au cours des années 2008 et 2009 nous avons réalisé des entretiens semi-directifs auprès d'une soixantaine d'acteurs de la sélection animale, des filières, de la distribution et des associations (de consommateurs, de protection des animaux ou de l'environnement). Les priorités e...

  5. First Priority, an expert system for prioritizing

    Energy Technology Data Exchange (ETDEWEB)

    Morton, G.R.; Hopson, P.C.

    1991-01-01

    Prioritizing lists of diverse entities such as projects, tasks, documents, recommendations or physical locations is a necessary part of business at DOE facilities. A key issue is whether or not this necessary and problematic activity of prioritizing is performed in a methodical, defensible and traceable manner, especially when the goals are hard to compare and measure. Sound methods of prioritizing are often not employed because of their complexity or difficulty in implementation. To overcome these problems, WSRC is developing an expert system. First Priority, which will provide individuals or committees a comprehensive process for prioritizing lists of any sort. A set of windows, editors, and pull-down menus guide the user in building and modifying an (inverted) weighted tree structure which represents the goals the prioritization is to advance. The process of building this structure is divided into four stages which are generally followed in order. These stages are: building the goal tree, ordering the goal tree nodes, weighting the goal tree nodes, and designing measurement methods for each leaf node. Based on the resultant structure an evaluation module is generated to evaluate the items of the list. This list is then prioritized and grouped into user-defined categories, taking into account cost or other resources. Additional First Priority tools provide sensitivity analysis, graphical displays of data, and reporting.

  6. First Priority, an expert system for prioritizing

    Energy Technology Data Exchange (ETDEWEB)

    Morton, G.R.; Hopson, P.C.

    1991-12-31

    Prioritizing lists of diverse entities such as projects, tasks, documents, recommendations or physical locations is a necessary part of business at DOE facilities. A key issue is whether or not this necessary and problematic activity of prioritizing is performed in a methodical, defensible and traceable manner, especially when the goals are hard to compare and measure. Sound methods of prioritizing are often not employed because of their complexity or difficulty in implementation. To overcome these problems, WSRC is developing an expert system. First Priority, which will provide individuals or committees a comprehensive process for prioritizing lists of any sort. A set of windows, editors, and pull-down menus guide the user in building and modifying an (inverted) weighted tree structure which represents the goals the prioritization is to advance. The process of building this structure is divided into four stages which are generally followed in order. These stages are: building the goal tree, ordering the goal tree nodes, weighting the goal tree nodes, and designing measurement methods for each leaf node. Based on the resultant structure an evaluation module is generated to evaluate the items of the list. This list is then prioritized and grouped into user-defined categories, taking into account cost or other resources. Additional First Priority tools provide sensitivity analysis, graphical displays of data, and reporting.

  7. CERN confirms LHC schedule

    CERN Multimedia

    2003-01-01

    The CERN Council held its 125th session on 20 June. Highlights of the meeting included confirmation that the LHC is on schedule for a 2007 start-up, and the announcement of a new organizational structure in 2004.

  8. Data-driven prioritization of chemicals for various water types using suspect screening LC-HRMS.

    Science.gov (United States)

    Sjerps, Rosa M A; Vughs, Dennis; van Leerdam, Jan A; ter Laak, Thomas L; van Wezel, Annemarie P

    2016-04-15

    For the prioritization of more than 5200 anthropogenic chemicals authorized on the European market, we use a large scale liquid chromatography-high resolution mass spectrometry (LC-HRMS) suspect screening study. The prioritization is based on occurrence in 151 water samples including effluent, surface water, ground water and drinking water. The suspect screening linked over 700 detected compounds with known accurate masses to one or multiple suspects. Using a prioritization threshold and removing false positives reduced this to 113 detected compounds linked to 174 suspects, 24 compounds reflect a confirmed structure by comparison with the pure reference standard. The prioritized compounds and suspects are relevant for detailed risk assessments after confirmation of their identity. Only one of the 174 prioritized compounds and suspects is mentioned in water quality regulations, and only 20% is mentioned on existing lists of potentially relevant chemicals. This shows the complementarity to commonly used target-based methods. The semi-quantitative total concentration, expressed as internal standard equivalents of detected compounds linked to suspects, in effluents is approximately 10 times higher than in surface waters, while ground waters and drinking waters show the lowest response. The average retention time, a measure for hydrophobicity, of the detected compounds per sample decreased from effluent to surface- and groundwater to drinking water, confirming the occurrence of more polar compounds in drinking water. The semi-quantitative total concentrations exceed the conservative and precautionary threshold of toxicological concern. Therefore, adverse effects of mixtures cannot be neglected without a more thorough risk assessment.

  9. Contribution au suivi contrôle et surveillance des pêches au Sénégal

    OpenAIRE

    Diarra, B.

    2002-01-01

    La gestion des ressources humaines constituent une priorité de la DPSP. Pour la formation des actions ont été faites dans le cadre du projet Appui à une gestion durable et paritaire du secteur de la pêche au Sénégal.

  10. Prioritizing Child Pornography Notifications: Predicting Direct Victimization.

    Science.gov (United States)

    Smid, Wineke; Schepers, Klaartje; Kamphuis, Jan Henk; van Linden, Sabine; Bartling, Sarah

    2015-08-01

    The growing number of notifications for child pornography (CP) possession constitutes a capacity problem for police forces entrusted with the investigation of these offenses. Notifications of CP offenses in which the investigation reveals concurrent direct victimization, in the form of contact offenses, grooming, online offending, or the production of CP material, form a potential target group for prioritization. The first of the twofold aims of this study was to validate the occurring distinction between mixed suspects (i.e., CP possession suspects who were also ever associated with direct victimization) and CP-only suspects (i.e., CP possession suspects who were never associated with direct victimization) to predict an outcome of the investigation including direct victimization. The second aim was to explore variables related to direct victimization among CP-only suspects. A total of 150 files of police investigations into notifications for CP offenses were studied. Findings confirmed significantly greater prevalence of direct victimization as an outcome of the investigation among mixed suspects than CP-only suspects (90% vs. 10%). Among CP-only suspects, direct victimization was predicted by (a) prior police contacts, charges, or convictions concerning noncontact sexual offending, (b) the confiscation of more than two computers during the house search, and (c) a more serious nature of the CP material that formed the basis for the notification in terms of younger victims and more extreme content. These variables may point to a small subgroup of heavily invested CP offenders who are at a higher risk to cross the line to direct victimization. Cross-validation of these preliminary findings is indicated. © The Author(s) 2014.

  11. Des tuiles, des toits et des couleurs

    OpenAIRE

    Bonnot, Thierry

    2007-01-01

    La Bourgogne est une des régions françaises dont l’image de marque est le plus imprégnée par la notion de tradition. Elle est présentée comme un terroir où il fait bon vivre, où la gastronomie demeure à travers les siècles une valeur de base, où les paysages sont majestueux et où la gloire passée est sans cesse rappelée par de somptueux monuments. Parmi quelques emblèmes, l’hôtel-Dieu de Beaune et ses toitures de tuiles colorées sont très souvent mobilisés pour représenter ces valeurs « tradi...

  12. Prioritizing dermatoses: rationally selecting guideline topics

    NARCIS (Netherlands)

    Borgonjen, R.J.; Everdingen, J.J. van; Kerkhof, P.C.M. van de; Spuls, P.I.

    2015-01-01

    BACKGROUND: Clinical practice guideline (CPG) development starts with selecting appropriate topics, as resources to develop a guideline are limited. However, a standardized method for topic selection is commonly missing and the way different criteria are used to prioritize is not clear. OBJECTIVES:

  13. Prioritizing tests for software fault localization

    NARCIS (Netherlands)

    Gonzalez, A.; Piel, E.A.B.; Gross, H.-G.; Van Gemund, A.J.C.

    2009-01-01

    Paper submitted for review at QSIC'10 Test prioritization techniques select test cases that maximize the confidence on the correctness of the system when the resources for quality assurance (QA) are limited. In the event of a test failing, the fault at the root of the failure has to be localized, a

  14. Prioritizing emerging zoonoses in the Netherlands

    NARCIS (Netherlands)

    A.H. Havelaar (Arie); F. van Rosse (Floor); C. Bucura (Catalin); M.A. Toetenel (Milou); J.A. Haagsma (Juanita); D. Kurowicka (Dorota); A.J.P. Heesterbeek (Hans); N. Speybroeck (Niko); M.F.M. Langelaar (Merel); J.W.B. van der Giessen (Joke); R.M. Cooke (Roger); M.A.H. Braks (Marieta)

    2010-01-01

    textabstractBackground: To support the development of early warning and surveillance systems of emerging zoonoses, we present a general method to prioritize pathogens using a quantitative, stochastic multi-criteria model, parameterized for the Netherlands. Methodology/Principal Findings: A risk

  15. Prioritizing Emerging Zoonoses in The Netherlands

    NARCIS (Netherlands)

    Havelaar, A.H.; Rosse, F.; Bubura, C.; Toetenel, M.A.; Haagsma, J.A.; Kurowicka, D.; Heesterbeek, J.A.P.; Giessen, van der J.W.B.

    2010-01-01

    Background To support the development of early warning and surveillance systems of emerging zoonoses, we present a general method to prioritize pathogens using a quantitative, stochastic multi-criteria model, parameterized for the Netherlands. Methodology/Principal Findings A risk score was based on

  16. Prioritizing emerging zoonoses in The Netherlands.

    NARCIS (Netherlands)

    Havelaar, A.H.|info:eu-repo/dai/nl/072306122; van Rosse, F.; Bucura, C.; Toetenel, M.A.; Haagsma, J.A.; Kurowicka, D.; Heesterbeek, J.A.P.|info:eu-repo/dai/nl/073321427; Speybroeck, N.; Langelaar, M.F.M.; van der Giessen, J.W.; Cooke, R.M.; Braks, M.A.H.

    2010-01-01

    To support the development of early warning and surveillance systems of emerging zoonoses, we present a general method to prioritize pathogens using a quantitative, stochastic multi-criteria model, parameterized for the Netherlands. A risk score was based on seven criteria, reflecting assessments of

  17. Prioritizing Emerging Zoonoses in The Netherlands

    NARCIS (Netherlands)

    Havelaar, A.H.; Van Rosse, F.; Bucura, C.; Toetenel, M.A.; Haagsma, J.A.; Kurowicka, D.; Heesterbeek, J.A.P.; Speybroeck, N.; Langelaar, M.F.M.; Cooke, R.M.; et al.

    2010-01-01

    Background: To support the development of early warning and surveillance systems of emerging zoonoses, we present a general method to prioritize pathogens using a quantitative, stochastic multi-criteria model, parameterized for the Netherlands. Methodology/Principal Findings: A risk score was based

  18. Behavioral Correlates of Prioritizing Popularity in Adolescence

    NARCIS (Netherlands)

    van Den Broek, Nina; Deutz, Marike H F; Schoneveld, Elke A.; Burk, William J.; Cillessen, Antonius H N

    2016-01-01

    Little is known about individual differences in adolescents’ motivation to achieve and maintain popularity. This study examined the moderating effects of prioritizing popularity on the associations between popularity and adjustment outcomes in late adolescence. Participants were 314 Dutch eleventh-g

  19. Prioritizing tests for software fault localization

    NARCIS (Netherlands)

    Gonzalez, A.; Piel, E.A.B.; Gross, H.-G.; Van Gemund, A.J.C.

    2009-01-01

    Paper submitted for review at QSIC'10 Test prioritization techniques select test cases that maximize the confidence on the correctness of the system when the resources for quality assurance (QA) are limited. In the event of a test failing, the fault at the root of the failure has to be localized,

  20. Prioritizing dermatoses: rationally selecting guideline topics

    NARCIS (Netherlands)

    Borgonjen, R.J.; Everdingen, J.J. van; Kerkhof, P.C.M. van de; Spuls, P.I.

    2015-01-01

    BACKGROUND: Clinical practice guideline (CPG) development starts with selecting appropriate topics, as resources to develop a guideline are limited. However, a standardized method for topic selection is commonly missing and the way different criteria are used to prioritize is not clear. OBJECTIVES:

  1. CONFIRMATION OF CIRCUMSTELLAR PHOSPHINE

    Energy Technology Data Exchange (ETDEWEB)

    Agúndez, M.; Cernicharo, J. [Instituto de Ciencia de Materiales de Madrid, CSIC, C/ Sor Juana Inés de la Cruz 3, E-28049 Cantoblanco (Spain); Decin, L. [Sterrenkundig Instituut Anton Pannekoek, University of Amsterdam, Science Park 904, NL-1098 Amsterdam (Netherlands); Encrenaz, P. [LERMA, Observatoire de Paris, 61 Av. de l' Observatoire, F-75014 Paris (France); Teyssier, D. [European Space Astronomy Centre, Urb. Villafranca del Castillo, P.O. Box 50727, E-28080 Madrid (Spain)

    2014-08-01

    Phosphine (PH{sub 3}) was tentatively identified a few years ago in the carbon star envelopes IRC +10216 and CRL 2688 from observations of an emission line at 266.9 GHz attributable to the J = 1-0 rotational transition. We report the detection of the J = 2-1 rotational transition of PH{sub 3} in IRC +10216 using the HIFI instrument on board Herschel, which definitively confirms the identification of PH{sub 3}. Radiative transfer calculations indicate that infrared pumping in excited vibrational states plays an important role in the excitation of PH{sub 3} in the envelope of IRC +10216, and that the observed lines are consistent with phosphine being formed anywhere between the star and 100 R {sub *} from the star, with an abundance of 10{sup –8} relative to H{sub 2}. The detection of PH{sub 3} challenges chemical models, none of which offer a satisfactory formation scenario. Although PH{sub 3} holds just 2% of the total available phosphorus in IRC +10216, it is, together with HCP, one of the major gas phase carriers of phosphorus in the inner circumstellar layers, suggesting that it could also be an important phosphorus species in other astronomical environments. This is the first unambiguous detection of PH{sub 3} outside the solar system, and is a further step toward a better understanding of the chemistry of phosphorus in space.

  2. Confirmation of circumstellar phosphine

    CERN Document Server

    Agundez, M; Decin, L; Encrenaz, P; Teyssier, D

    2014-01-01

    Phosphine (PH3) was tentatively identified a few years ago in the carbon star envelopes IRC+10216 and CRL2688 from observations of an emission line at 266.9 GHz attributable to the J=1-0 rotational transition. We report the detection of the J=2-1 rotational transition of PH3 in IRC+10216 using the HIFI instrument on board Herschel, which definitively confirms the identification of PH3. Radiative transfer calculations indicate that infrared pumping to excited vibrational states plays an important role in the excitation of PH3 in the envelope of IRC+10216, and that the observed lines are consistent with phosphine being formed anywhere between the star and 100 R* from the star, with an abundance of 1e-8 relative to H2. The detection of PH3 challenges chemical models, none of which offers a satisfactory formation scenario. Although PH3 locks just 2 % of the total available phosphorus in IRC+10216, it is together with HCP, one of the major gas phase carriers of phosphorus in the inner circumstellar layers, suggest...

  3. Ontology-Based Prediction and Prioritization of Gene Functional Annotations.

    Science.gov (United States)

    Chicco, Davide; Masseroli, Marco

    2016-01-01

    Genes and their protein products are essential molecular units of a living organism. The knowledge of their functions is key for the understanding of physiological and pathological biological processes, as well as in the development of new drugs and therapies. The association of a gene or protein with its functions, described by controlled terms of biomolecular terminologies or ontologies, is named gene functional annotation. Very many and valuable gene annotations expressed through terminologies and ontologies are available. Nevertheless, they might include some erroneous information, since only a subset of annotations are reviewed by curators. Furthermore, they are incomplete by definition, given the rapidly evolving pace of biomolecular knowledge. In this scenario, computational methods that are able to quicken the annotation curation process and reliably suggest new annotations are very important. Here, we first propose a computational pipeline that uses different semantic and machine learning methods to predict novel ontology-based gene functional annotations; then, we introduce a new semantic prioritization rule to categorize the predicted annotations by their likelihood of being correct. Our tests and validations proved the effectiveness of our pipeline and prioritization of predicted annotations, by selecting as most likely manifold predicted annotations that were later confirmed.

  4. Technology Alignment and Portfolio Prioritization (TAPP)

    Science.gov (United States)

    Funaro, Gregory V.; Alexander, Reginald A.

    2015-01-01

    Technology Alignment and Portfolio Prioritization (TAPP) is a method being developed by the Advanced Concepts Office, at NASA Marshall Space Flight Center. The TAPP method expands on current technology assessment methods by incorporating the technological structure underlying technology development, e.g., organizational structures and resources, institutional policy and strategy, and the factors that motivate technological change. This paper discusses the methods ACO is currently developing to better perform technology assessments while taking into consideration Strategic Alignment, Technology Forecasting, and Long Term Planning.

  5. Characteristics of predictor sets found using differential prioritization

    Directory of Open Access Journals (Sweden)

    Chetty Madhu

    2007-06-01

    Full Text Available Abstract Background Feature selection plays an undeniably important role in classification problems involving high dimensional datasets such as microarray datasets. For filter-based feature selection, two well-known criteria used in forming predictor sets are relevance and redundancy. However, there is a third criterion which is at least as important as the other two in affecting the efficacy of the resulting predictor sets. This criterion is the degree of differential prioritization (DDP, which varies the emphases on relevance and redundancy depending on the value of the DDP. Previous empirical works on publicly available microarray datasets have confirmed the effectiveness of the DDP in molecular classification. We now propose to establish the fundamental strengths and merits of the DDP-based feature selection technique. This is to be done through a simulation study which involves vigorous analyses of the characteristics of predictor sets found using different values of the DDP from toy datasets designed to mimic real-life microarray datasets. Results A simulation study employing analytical measures such as the distance between classes before and after transformation using principal component analysis is implemented on toy datasets. From these analyses, the necessity of adjusting the differential prioritization based on the dataset of interest is established. This conclusion is supported by comparisons against both simplistic rank-based selection and state-of-the-art equal-priorities scoring methods, which demonstrates the superiority of the DDP-based feature selection technique. Reapplying similar analyses to real-life multiclass microarray datasets provides further confirmation of our findings and of the significance of the DDP for practical applications. Conclusion The findings have been achieved based on analytical evaluations, not empirical evaluation involving classifiers, thus providing further basis for the usefulness of the DDP and

  6. Text mining in cancer gene and pathway prioritization.

    Science.gov (United States)

    Luo, Yuan; Riedlinger, Gregory; Szolovits, Peter

    2014-01-01

    Prioritization of cancer implicated genes has received growing attention as an effective way to reduce wet lab cost by computational analysis that ranks candidate genes according to the likelihood that experimental verifications will succeed. A multitude of gene prioritization tools have been developed, each integrating different data sources covering gene sequences, differential expressions, function annotations, gene regulations, protein domains, protein interactions, and pathways. This review places existing gene prioritization tools against the backdrop of an integrative Omic hierarchy view toward cancer and focuses on the analysis of their text mining components. We explain the relatively slow progress of text mining in gene prioritization, identify several challenges to current text mining methods, and highlight a few directions where more effective text mining algorithms may improve the overall prioritization task and where prioritizing the pathways may be more desirable than prioritizing only genes.

  7. Utility-aware screening with clique-oriented prioritization.

    Science.gov (United States)

    Swamidass, S Joshua; Calhoun, Bradley T; Bittker, Joshua A; Bodycombe, Nicole E; Clemons, Paul A

    2012-01-23

    Most methods of deciding which hits from a screen to send for confirmatory testing assume that all confirmed actives are equally valuable and aim only to maximize the number of confirmed hits. In contrast, "utility-aware" methods are informed by models of screeners' preferences and can increase the rate at which the useful information is discovered. Clique-oriented prioritization (COP) extends a recently proposed economic framework and aims--by changing which hits are sent for confirmatory testing--to maximize the number of scaffolds with at least two confirmed active examples. In both retrospective and prospective experiments, COP enables accurate predictions of the number of clique discoveries in a batch of confirmatory experiments and improves the rate of clique discovery by more than 3-fold. In contrast, other similarity-based methods like ontology-based pattern identification (OPI) and local hit-rate analysis (LHR) reduce the rate of scaffold discovery by about half. The utility-aware algorithm used to implement COP is general enough to implement several other important models of screener preferences.

  8. Disease Gene Prioritization Using Network and Feature

    Science.gov (United States)

    Agam, Gady; Balasubramanian, Sandhya; Xu, Jinbo; Gilliam, T. Conrad; Maltsev, Natalia; Börnigen, Daniela

    2015-01-01

    Abstract Identifying high-confidence candidate genes that are causative for disease phenotypes, from the large lists of variations produced by high-throughput genomics, can be both time-consuming and costly. The development of novel computational approaches, utilizing existing biological knowledge for the prioritization of such candidate genes, can improve the efficiency and accuracy of the biomedical data analysis. It can also reduce the cost of such studies by avoiding experimental validations of irrelevant candidates. In this study, we address this challenge by proposing a novel gene prioritization approach that ranks promising candidate genes that are likely to be involved in a disease or phenotype under study. This algorithm is based on the modified conditional random field (CRF) model that simultaneously makes use of both gene annotations and gene interactions, while preserving their original representation. We validated our approach on two independent disease benchmark studies by ranking candidate genes using network and feature information. Our results showed both high area under the curve (AUC) value (0.86), and more importantly high partial AUC (pAUC) value (0.1296), and revealed higher accuracy and precision at the top predictions as compared with other well-performed gene prioritization tools, such as Endeavour (AUC-0.82, pAUC-0.083) and PINTA (AUC-0.76, pAUC-0.066). We were able to detect more target genes (9/18/19/27) on top positions (1/5/10/20) compared to Endeavour (3/11/14/23) and PINTA (6/10/13/18). To demonstrate its usability, we applied our method to a case study for the prediction of molecular mechanisms contributing to intellectual disability and autism. Our approach was able to correctly recover genes related to both disorders and provide suggestions for possible additional candidates based on their rankings and functional annotations. PMID:25844670

  9. Explicit criteria for prioritization of cataract surgery

    Directory of Open Access Journals (Sweden)

    Escobar Antonio

    2006-03-01

    Full Text Available Abstract Background Consensus techniques have been used previously to create explicit criteria to prioritize cataract extraction; however, the appropriateness of the intervention was not included explicitly in previous studies. We developed a prioritization tool for cataract extraction according to the RAND method. Methods Criteria were developed using a modified Delphi panel judgment process. A panel of 11 ophthalmologists was assembled. Ratings were analyzed regarding the level of agreement among panelists. We studied the effect of all variables on the final panel score using general linear and logistic regression models. Priority scoring systems were developed by means of optimal scaling and general linear models. The explicit criteria developed were summarized by means of regression tree analysis. Results Eight variables were considered to create the indications. Of the 310 indications that the panel evaluated, 22.6% were considered high priority, 52.3% intermediate priority, and 25.2% low priority. Agreement was reached for 31.9% of the indications and disagreement for 0.3%. Logistic regression and general linear models showed that the preoperative visual acuity of the cataractous eye, visual function, and anticipated visual acuity postoperatively were the most influential variables. Alternative and simple scoring systems were obtained by optimal scaling and general linear models where the previous variables were also the most important. The decision tree also shows the importance of the previous variables and the appropriateness of the intervention. Conclusion Our results showed acceptable validity as an evaluation and management tool for prioritizing cataract extraction. It also provides easy algorithms for use in clinical practice.

  10. Prioritization and Ranking Problems Exporting Iranian Saffron

    Directory of Open Access Journals (Sweden)

    Reza Askandari

    2013-10-01

    Full Text Available The main objective of this study is to prioritize and rank problems exporting Iranian saffron. Based on a comprehensive review of the literature on issues related to data and information collected from questionnaires, with 816% reliability is used. In this study, the sample of managers and sales and marketing company is exporting Iranian saffron is the sample size of 231 subjects. The results of this study are positive and significant relationship between the dependent variable and the independent variables of export performance of export barriers exist.

  11. Loin des sciences sociales.

    Directory of Open Access Journals (Sweden)

    René-Éric Dagorn

    2002-05-01

    Full Text Available Plusieurs numéros de Livres Hebdo et du Monde des Livres des mois de janvier-février 2002 permettent de proposer un rapide survol des grandes ventes de l’année 2001 et de quelques tendances éditoriales de l’année 2002. Quelques points ressortent particulièrement de la lecture des articles de ces deux sources : l’intérêt de la nouvelle méthode d’estimation des ventes proposée par l’institut Ipsos et Livres Hebdo , le tableau des grandes ventes en 2001 (et ...

  12. La metamorphose des cypris femelles des Rhizocephales

    NARCIS (Netherlands)

    Veillet, A.

    1964-01-01

    Depuis la découverte de la métamorphose des cypris de Sacculina carcini Thompson par Delage, peu de biologistes se sont intéressés au développement des Rhizocéphales. On admet aujourd'hui que tous les Cirripèdes parasites ont, comme Sacculina carcini, une forme kentrogone qui inocule le parasite au

  13. Investigation of the molecular relationship between breast cancer and obesity by candidate gene prioritization methods

    OpenAIRE

    Saba Garshasbi; Dariush Salimi; Abbas Doosti

    2015-01-01

    Background: Cancer and obesity are two major public health concerns. More than 12 million cases of cancer are reported annually. Many reports confirmed obesity as a risk factor for cancer. The molecular relationship between obesity and breast cancer has not been clear yet. The purpose of this study was to investigate priorities of effective genes in the molecular relationship between obesity and breast cancer. Methods: In this study, computer simulation method was used for prioritizing the ge...

  14. Semantic prioritization of novel causative genomic variants

    KAUST Repository

    Boudellioua, Imane

    2017-04-17

    Discriminating the causative disease variant(s) for individuals with inherited or de novo mutations presents one of the main challenges faced by the clinical genetics community today. Computational approaches for variant prioritization include machine learning methods utilizing a large number of features, including molecular information, interaction networks, or phenotypes. Here, we demonstrate the PhenomeNET Variant Predictor (PVP) system that exploits semantic technologies and automated reasoning over genotype-phenotype relations to filter and prioritize variants in whole exome and whole genome sequencing datasets. We demonstrate the performance of PVP in identifying causative variants on a large number of synthetic whole exome and whole genome sequences, covering a wide range of diseases and syndromes. In a retrospective study, we further illustrate the application of PVP for the interpretation of whole exome sequencing data in patients suffering from congenital hypothyroidism. We find that PVP accurately identifies causative variants in whole exome and whole genome sequencing datasets and provides a powerful resource for the discovery of causal variants.

  15. Prioritizing dermatoses: rationally selecting guideline topics.

    Science.gov (United States)

    Borgonjen, R J; van Everdingen, J J E; van de Kerkhof, P C M; Spuls, Ph I

    2015-08-01

    Clinical practice guideline (CPG) development starts with selecting appropriate topics, as resources to develop a guideline are limited. However, a standardized method for topic selection is commonly missing and the way different criteria are used to prioritize is not clear. To select and prioritize dermatological topics for CPG development and elucidate criteria dermatologists find important in selecting guideline topics. All 410 dermatologists in the Netherlands were asked to create a top 20 of dermatological topics for which a guideline would be desirable, regardless of existing guidelines. They also rated, on a 5-point Likert scale, 10 determinative criteria derived from a combined search in literature and across (inter)national guideline developers. Top 20 topics received scores ranging from 0.01 to 0.2 and combined scores yielded a total score. The 118 surveys (response 29%) identified 157 different topics. Melanoma, squamous cell carcinoma, basal cell carcinoma, psoriasis and atopic dermatitis are top priority guideline topics. Venous leg ulcer, vasculitis, varicose veins, urticaria, acne, Lyme borreliosis, cutaneous lupus erythematosus, pruritus, syphilis, lymphoedema, decubitus ulcer, hidradenitis suppurativa, androgenic alopecia and bullous pemphigoïd complete the top 20. A further 15 topics have overlapping confidence intervals. Mortality and healthcare costs are regarded as less important criteria in topic selection (P topics. Respondents mostly agree with (inter)national guideline programmes and literature concerning the criteria important to selecting guideline topics. © 2014 European Academy of Dermatology and Venereology.

  16. ANALYSE DES MODES DE GESTION DES ENTREPRISES ...

    African Journals Online (AJOL)

    Administrateur

    L'étude de l'art et des biens culturels en général est longtemps restée en ... en économie et management), Université d'Angers / Chef de projet chez Arterial Network. ... culturelles publiques sont apparues à partir de la fin des années 1990.

  17. Des racines et des ailes

    Directory of Open Access Journals (Sweden)

    Stéphanie Vincent-Geslin

    2012-05-01

    Full Text Available Les mobilités pendulaires semblent être en augmentation en Europe depuis une dizaine d’années. Cette croissance du temps passé à se déplacer amène à remettre en question la conjecture de Zahavi et apparaît relativement inexplicable en regard du paradigme classique de l’acteur rationnel traditionnellement utilisé dans le champ des transports. Si, dans la littérature, les temps de déplacements sont principalement expliqués par le contexte résidentiel, la forme urbaine et le travail, ce cadre explicatif ne dit rien des processus de décision eux-mêmes qui amènent aux pendularités intensives.À partir d’une enquête qualitative menée auprès de pendulaires français, suisses et belges, cette contribution propose d’analyser les arbitrages et les éléments déterminants des processus de la grande pendularité. Les mobilités quotidiennes pendulaires apparaissent comme le résultat de compromis entre activité professionnelle, attachement résidentiel et choix de vie et prennent ainsi la forme de stratégies de conciliation entre vie privée et vie professionnelle. Ces mobilités spatiales permettent alors paradoxalement la préservation des ancrages résidentiels, sociaux et familiaux.Roots and wings. Long-distance commuting patterns, or how to conciliate professional and personal lifeLong-distance commuting patterns appear to be increasing in Europe over the last ten years. These raising mobility patterns lead to reappraise the Zahavi conjecture and appear largely inexplicable by the classical rational actor paradigm traditionally used in transportation research. In literature, commuting is mainly explained by residential contexts, urban forms and job. Nevertheless this theoretical frame says little about the decision-making processes themselves. Based on a qualitative survey conducted in three European countries - France, Belgium and Switzerland – among a population of high commuters, this paper proposes an analysis of

  18. Prioritization of interventions for strengthening architectural heritage

    Directory of Open Access Journals (Sweden)

    Fatemeh Mehdizadeh Saradj

    2017-09-01

    Full Text Available Architectural heritage is continuously exposed to natural disasters, such as strong earthquakes and this highlights the importance of reducing their vulnerability. While it is not possible to simultaneously strengthen all architectural heritage structures due to the limited skilled labour and budget restrictions, different buildings may need different treatments due to differences in exposure to seismic hazard, relative importance and vulnerability. Therefore, there is a need for a decision making strategy to find optimized solutions to achieve the highest possible stability and benefits. The primary objective of this research is to develop a practical step-by-step decision making process for the planning and prioritization of interventions in architectural heritage structures based on the level of seismic hazard, vulnerability and condition assessment, available preservation and strengthening techniques, compatibility with conservation ethics, available budget and expected benefits in various time schedules. The proposed methodology, is shown by diagram and mathematical formulae, and is demonstrated through a case study example.

  19. Data Partitioning Technique for Improved Video Prioritization

    Directory of Open Access Journals (Sweden)

    Ismail Amin Ali

    2017-07-01

    Full Text Available A compressed video bitstream can be partitioned according to the coding priority of the data, allowing prioritized wireless communication or selective dropping in a congested channel. Known as data partitioning in the H.264/Advanced Video Coding (AVC codec, this paper introduces a further sub-partition of one of the H.264/AVC codec’s three data-partitions. Results show a 5 dB improvement in Peak Signal-to-Noise Ratio (PSNR through this innovation. In particular, the data partition containing intra-coded residuals is sub-divided into data from: those macroblocks (MBs naturally intra-coded, and those MBs forcibly inserted for non-periodic intra-refresh. Interactive user-to-user video streaming can benefit, as then HTTP adaptive streaming is inappropriate and the High Efficiency Video Coding (HEVC codec is too energy demanding.

  20. ADAPTIVE CONTENT BASED TEXTUAL INFORMATION SOURCE PRIORITIZATION

    Directory of Open Access Journals (Sweden)

    Nikhil Mitra

    2014-10-01

    Full Text Available The world-wide-web offers a posse of textual information sources which are ready to be utilized for several applications. In fact, given the rapidly evolving nature of online data, there is a real risk of information overload unless we continue to develop and refine techniques to meaningfully segregate these information sources. Specifically, there is a dearth of content-oriented and intelligent techniques which can learn from past search experiences and also adapt to a user’s specific requirements during her current search. In this paper, we tackle the core issue of prioritizing textual information sources on the basis of the relevance of their content to the central theme that a user is currently exploring. We propose a new Source Prioritization Algorithm that adopts an iterative learning approach to assess the proclivity of given information sources towards a set of user-defined seed words in order to prioritise them. The final priorities obtained serve as initial priorities for the next search request. This serves a dual purpose. Firstly, the system learns incrementally from several users’ cumulative search experiences and re-adjusts the source priorities to reflect the acquired knowledge. Secondly, the refreshed source priorities are utilized to direct a user’s current search towards more relevant sources while adapting also to the new set of keywords acquired from that user. Experimental results show that the proposed algorithm progressively improves the system’s ability to discern between different sources, even in the presence of several random sources. Further, it is able to scale well to identify the augmented information source when a new enriched information source is generated by clubbing existing ones.

  1. Prioritizing Test Cases Using Business CriticalityTest Value

    Directory of Open Access Journals (Sweden)

    Sonali Khandai; Arup Abhinna Acharya; Durga Prasad Mohapatra

    2012-05-01

    Full Text Available Software maintenance is an important and costly activity of the software development lifecycle. Regression testing is the process of validating modifications introduced in a system during software maintenance. It is very inefficient to re-execute every test case in regression testing for small changes. This issue of retesting of software systems can be handled using a good test case prioritization technique. A prioritization technique schedules the test cases for execution so that the test cases with higher priority executed before lower priority. The objective of test case prioritization is to detect fault as early as possible. Early fault detection can provide a faster feedback generating a scope for debuggers to carry out their task at an early stage. Model Based Prioritization has an edge over Code Based Prioritization techniques. The issue of dynamic changes that occur during the maintenance phase of software development can only be addressed by maintaining statistical data for system models, change models and fault models. In this paper we present a novel approach for test case prioritization by evaluating the Business Criticality Value (BCV of the various functions present in the software using the statistical data. Then according to the business criticality value of various functions present in the change and fault model we prioritize the test cases are prioritized.

  2. Cost-Prioritized Droop Schemes for Autonomous AC Microgrids

    DEFF Research Database (Denmark)

    Nutkani, Inam Ullah; Loh, Poh Chiang; Wang, Peng

    2015-01-01

    This paper presents two cost-prioritized droop sche- mes for distributed generators (DGs) in a rural or islanded microgrid. Dispatch prioritization of the schemes allows autonomous identification of the appropriate DGs for generation, in accordance to the overall load conditions of the microgrid....

  3. False memory and importance: can we prioritize encoding without consequence?

    Science.gov (United States)

    Bui, Dung C; Friedman, Michael C; McDonough, Ian M; Castel, Alan D

    2013-10-01

    Given the large amount of information that we encounter, we often must prioritize what information we attempt to remember. Although critical for everyday functioning, relatively little research has focused on how people prioritize the encoding of information. Recent research has shown that people can and do selectively remember information assigned with higher, relative to lower, importance. However, the mechanisms underlying this prioritization process and the consequences of these processes are still not well understood. In the present study, we sought to better understand these prioritization processes and whether implementing these processes comes at the cost of memory accuracy, by increasing false memories. We used a modified form of the Deese/Roediger-McDermott (DRM) paradigm, in which participants studied DRM lists, with each list paired with low, medium, or high point values. In Experiment 1, encoding higher values led to more false memories than did encoding lower values, possibly because prioritizing information enhanced relational processing among high-value words. In Experiment 2, disrupting relational processing selectively reduced false memories for high-value words. Finally, in Experiment 3, facilitating relational processing selectively increased false memories for low-value words. These findings suggest that while prioritizing information can enhance true memory, this process concomitantly increases false memories. Furthermore, the mechanism underlying these prioritization processes depends on the ability to successfully engage in relational processing. Thus, how we prioritize the encoding of incoming information can come at a cost in terms of accurate memory.

  4. Prioritizing emerging zoonoses in the Netherlands.

    Directory of Open Access Journals (Sweden)

    Arie H Havelaar

    Full Text Available BACKGROUND: To support the development of early warning and surveillance systems of emerging zoonoses, we present a general method to prioritize pathogens using a quantitative, stochastic multi-criteria model, parameterized for the Netherlands. METHODOLOGY/PRINCIPAL FINDINGS: A risk score was based on seven criteria, reflecting assessments of the epidemiology and impact of these pathogens on society. Criteria were weighed, based on the preferences of a panel of judges with a background in infectious disease control. CONCLUSIONS/SIGNIFICANCE: Pathogens with the highest risk for the Netherlands included pathogens in the livestock reservoir with a high actual human disease burden (e.g. Campylobacter spp., Toxoplasma gondii, Coxiella burnetii or a low current but higher historic burden (e.g. Mycobacterium bovis, rare zoonotic pathogens in domestic animals with severe disease manifestations in humans (e.g. BSE prion, Capnocytophaga canimorsus as well as arthropod-borne and wildlife associated pathogens which may pose a severe risk in future (e.g. Japanese encephalitis virus and West-Nile virus. These agents are key targets for development of early warning and surveillance.

  5. Bug Prioritization to Facilitate Bug Report Triage

    Institute of Scientific and Technical Information of China (English)

    Jaweria Kanwal; Onaiza Maqbool

    2012-01-01

    The large number of new bug reports received in bug repositories of software systems makes their management a challenging task.Handling these reports manually is time consuming,and often results in delaying the resolution of important bugs. To address this issue,a recommender may be developed which automatically prioritizes the new bug reports.In this paper,we propose and evaluate a classification based approach to build such a recommender.We use the Na(ǐ)ve Bayes and Support Vector Machine (SVM) classifiers,and present a comparison to evaluate which classifier performs better in terms of accuracy.Since a bug report contains both categorical and text features,another evaluation we perform is to determine the combination of features that better determines the priority of a bug.To evaluate the bug priority recommender,we use precision and recall measures and also propose two new measures,Nearest False Negatives (NFN) and Nearest False Positives (NFP),which provide insight into the results produced by precision and recall.Our findings are that the results of SVM are better than the Na(ǐ)ve Bayes algorithm for text features,whereas for categorical features,Na(ǐ)ve Bayes performance is better than SVM.The highest accurácy is achieved with SVM when categorical and text features are combined for training.

  6. Prioritizing pesticide compounds for analytical methods development

    Science.gov (United States)

    Norman, Julia E.; Kuivila, Kathryn; Nowell, Lisa H.

    2012-01-01

    The U.S. Geological Survey (USGS) has a periodic need to re-evaluate pesticide compounds in terms of priorities for inclusion in monitoring and studies and, thus, must also assess the current analytical capabilities for pesticide detection. To meet this need, a strategy has been developed to prioritize pesticides and degradates for analytical methods development. Screening procedures were developed to separately prioritize pesticide compounds in water and sediment. The procedures evaluate pesticide compounds in existing USGS analytical methods for water and sediment and compounds for which recent agricultural-use information was available. Measured occurrence (detection frequency and concentrations) in water and sediment, predicted concentrations in water and predicted likelihood of occurrence in sediment, potential toxicity to aquatic life or humans, and priorities of other agencies or organizations, regulatory or otherwise, were considered. Several existing strategies for prioritizing chemicals for various purposes were reviewed, including those that identify and prioritize persistent, bioaccumulative, and toxic compounds, and those that determine candidates for future regulation of drinking-water contaminants. The systematic procedures developed and used in this study rely on concepts common to many previously established strategies. The evaluation of pesticide compounds resulted in the classification of compounds into three groups: Tier 1 for high priority compounds, Tier 2 for moderate priority compounds, and Tier 3 for low priority compounds. For water, a total of 247 pesticide compounds were classified as Tier 1 and, thus, are high priority for inclusion in analytical methods for monitoring and studies. Of these, about three-quarters are included in some USGS analytical method; however, many of these compounds are included on research methods that are expensive and for which there are few data on environmental samples. The remaining quarter of Tier 1

  7. Prioritized System Science Targets for Heliophysics

    Science.gov (United States)

    Spann, James Frederick; Christensen, Andrew B.; SaintCyr, Orville Chris; Posner, Arik; Giles, Barbara L.

    2009-01-01

    Heliophysics is a discipline that investigates the science at work from the interface of Earth and space, to the core of the Sun, and to the outer edge of our solar system. This solar-interplanetary-planetary system is vast and inherently coupled on many spatial, temporal and energy scales. The Sun's explosive energy output creates complicated field and plasma structures that when coupled with our terrestrial magnetized space, generates an extraordinary complex environment that has practical implications for humanity as we are becoming increasingly dependent on space-based assets. This immense volume of our cosmic neighborhood is the domain of heliophysics. Understanding this domain and the dominant mechanisms that control the transfer of mass and energy requires a system approach that addresses all aspects and regions of the system. The 2009 NASA Heliophysics Roadmap presents a science-focused strategic approach to advance the goal of heliophysics: why does the Sun vary; how do the Earth and heliosphere respond; and what are the impacts on humanity? This talk will present the top 6 prioritized science targets to understand the coupled heliophysics system as presented in the 2009 NASA Heliophysics Roadmap. An exposition of each science target and how it addresses outstanding questions in heliophysics will be discussed.

  8. Requirements Prioritization: Challenges and Techniques for Quality Software Development

    Directory of Open Access Journals (Sweden)

    Muhammad Abdullah Awais

    2016-04-01

    Full Text Available Every organization is aware of the consequences and importance of requirements for the development of quality software product whether local or global. Requirement engineering phase of development with focus on the prioritization of requirements is going under huge research every day because in any development methodology, all requirements cannot be implemented at same time so requirements are prioritized to be implemented to give solution as early as possible in phases as scheduled in incremental fashion. Numerous frameworks and practices have been devised, in progress and some being discovered day by day. With such huge knowledge database and research available, it has always been confusing to decide which technique to follow to gain maximum results. Thus many projects fail because of the wrong choice in requirement prioritization because it’s really difficult to employ right technique and framework at right time. And problems do not end here rather due to strict deadlines, it’s often best to develop system in parts by different team members dispersed globally with diverse methodologies and differences and in this situation it becomes more difficult to prioritize requirements. Main focus would be on ETVX based prioritization [1] for in house development and requirement prioritization of software developed globally by diverse team members [2]. This paper will try to provide an overview of different prioritization techniques for software requirement, and a critical analysis of ETVX based model will be presented to highlight issues and challenges in this proposed model of requirement prioritization in [1] and improved version of this model will be presented while an analysis of requirement prioritization for software developed in global environment [2] also be presented.

  9. Liste des intrants 2015

    OpenAIRE

    Speiser, Bernhard; Tamm, Lucius; Maurer, Veronika; Berner, Alfred; Schneider, Claudia; Chevillat, Véronique

    2015-01-01

    La liste des intrants contient tous les produits phytosanitaires, les engrais, les substrats du commerce, les produits de lutte contre les mouches des étables, les agents d'ensilage, les aliments minéraux et complémentaires, les produits pour la désinfection des stabulations et les produits contre les maladies des abeilles autorisés pour l'agriculture biologique. Cette liste est contraignante pour les producteurs de Bio Suisse. Sur les fermes Bio Suisse, seuls les produits mentionnés sont aut...

  10. The role of risk-based prioritization in total quality management

    Energy Technology Data Exchange (ETDEWEB)

    Bennett, C.T.

    1994-10-01

    The climate in which government managers must make decisions grows more complex and uncertain. All stakeholders - the public, industry, and Congress - are demanding greater consciousness, responsibility, and accountability of programs and their budgets. Yet, managerial decisions have become multifaceted, involve greater risk, and operate over much longer time periods. Over the last four or five decades, as policy analysis and decisions became more complex, scientists from psychology, operations research, systems science, and economics have developed a more or less coherent process called decision analysis to aid program management. The process of decision analysis - a systems theoretic approach - provides the backdrop for this paper. The Laboratory Integrated Prioritization System (LIPS) has been developed as a systems analytic and risk-based prioritization tool to aid the management of the Tri-Labs` (Lawrence Livermore, Los Alamos, and Sandia) operating resources. Preliminary analyses of the effects of LIPS has confirmed the practical benefits of decision and systems sciences - the systematic, quantitative reduction in uncertainty. To date, the use of LIPS - and, hence, its value - has been restricted to resource allocation within the Tri-Labs` operations budgets. This report extends the role of risk-based prioritization to the support of DOE Total Quality Management (TQM) programs. Furthermore, this paper will argue for the requirement to institutionalize an evolutionary, decision theoretic approach to the policy analysis of the Department of Energy`s Program Budget.

  11. An Invasive Plant Inventory and Early Detection Prioritization Tool

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — In 2010-2013, Utah State University partnered with the U. S. Fish and Wildlife Service (USFWS) to conduct invasive plant prioritization workshops and inventories on...

  12. An Evaluation of Requirement Prioritization Techniques with ANP

    Directory of Open Access Journals (Sweden)

    Javed ali Khan

    2016-07-01

    Full Text Available This article elaborates an evaluation of seven software requirements prioritization methods (ANP, binary search tree, AHP, hierarchy AHP, spanning tree matrix, priority group and bubble sort. Based on the case study of local project (automation of Mobilink franchise system, the experiment is conducted by students in the Requirement Engineering course in the department of Software Engineering at the University of Science and Technology Bannu, Khyber Pakhtunkhawa, Pakistan. Parameters/ measures used for the experiment are consistency indication, scale of measurement, interdependence, required number of decisions, total time consumption, time consumption per decision, ease of use, reliability of results and fault tolerance; on which requirements prioritization techniques are evaluated. The results of experiment show that ANP is the most successful prioritization methodology among all the available prioritization methodologies.

  13. Points to consider for prioritizing clinical genetic testing services

    DEFF Research Database (Denmark)

    Severin, Franziska; Borry, Pascal; Cornel, Martina C

    2015-01-01

    of prioritization criteria would be desirable. A decision process following the accountability for reasonableness framework was undertaken, including a multidisciplinary EuroGentest/PPPC-ESHG workshop to develop shared prioritization criteria. Resources are currently too limited to fund all the beneficial genetic......Given the cost constraints of the European health-care systems, criteria are needed to decide which genetic services to fund from the public budgets, if not all can be covered. To ensure that high-priority services are available equitably within and across the European countries, a shared set...... testing services available in the next decade. Ethically and economically reflected prioritization criteria are needed. Prioritization should be based on considerations of medical benefit, health need and costs. Medical benefit includes evidence of benefit in terms of clinical benefit, benefit...

  14. a comparative study of prioritized handoff schemes with guard ...

    African Journals Online (AJOL)

    eobe

    These performance metrics are computed by using the analytical expressions developed for these the analytical expressions .... generic prioritization schemes have been proposed. .... dynamic channel allocation (DCA) strategy. The modified ...

  15. Habitat inventory for prioritized management on Madison WMD

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Final report on a project at Madison Wetland Management District to implement a standardized decision making tool developed to prioritize Waterfowl Production Area's...

  16. Using farmer-prioritized vertisol management options for enhanced ...

    African Journals Online (AJOL)

    Using farmer-prioritized vertisol management options for enhanced green gram ... PROMOTING ACCESS TO AFRICAN RESEARCH ... soil management options needed to be instituted) it was at the marketing stage that this force was directed.

  17. Systematic prioritization and integrative analysis of copy number variations in schizophrenia reveal key schizophrenia susceptibility genes.

    Science.gov (United States)

    Luo, Xiongjian; Huang, Liang; Han, Leng; Luo, Zhenwu; Hu, Fang; Tieu, Roger; Gan, Lin

    2014-11-01

    Schizophrenia is a common mental disorder with high heritability and strong genetic heterogeneity. Common disease-common variants hypothesis predicts that schizophrenia is attributable in part to common genetic variants. However, recent studies have clearly demonstrated that copy number variations (CNVs) also play pivotal roles in schizophrenia susceptibility and explain a proportion of missing heritability. Though numerous CNVs have been identified, many of the regions affected by CNVs show poor overlapping among different studies, and it is not known whether the genes disrupted by CNVs contribute to the risk of schizophrenia. By using cumulative scoring, we systematically prioritized the genes affected by CNVs in schizophrenia. We identified 8 top genes that are frequently disrupted by CNVs, including NRXN1, CHRNA7, BCL9, CYFIP1, GJA8, NDE1, SNAP29, and GJA5. Integration of genes affected by CNVs with known schizophrenia susceptibility genes (from previous genetic linkage and association studies) reveals that many genes disrupted by CNVs are also associated with schizophrenia. Further protein-protein interaction (PPI) analysis indicates that protein products of genes affected by CNVs frequently interact with known schizophrenia-associated proteins. Finally, systematic integration of CNVs prioritization data with genetic association and PPI data identifies key schizophrenia candidate genes. Our results provide a global overview of genes impacted by CNVs in schizophrenia and reveal a densely interconnected molecular network of de novo CNVs in schizophrenia. Though the prioritized top genes represent promising schizophrenia risk genes, further work with different prioritization methods and independent samples is needed to confirm these findings. Nevertheless, the identified key candidate genes may have important roles in the pathogenesis of schizophrenia, and further functional characterization of these genes may provide pivotal targets for future therapeutics and

  18. Gestion des risques

    CERN Document Server

    Louisot, Jean-Paul

    2009-01-01

    Depuis le début du lie siècle, la gestion des risques connaît une véritable révolution culturelle. Jusqu'alors fonction technique, centrée autour de l'achat de couverture d'assurances, elle est devenue une discipline managériale et transversale : une valise d'instruments que chaque manager doit connaître et appliquer quels que soient son domaine de compétence et ses missions au sein de l'organisation. En effet, la gestion des risques est une culture qui doit être assimilée par chacun des acteurs. C'est précisément l'ambition des 101 questions rassemblées dans cet ouvrage : apporter à chaque manager d'entreprise, de collectivité, d'établissement de santé..., des réponses claires au " pourquoi " et au " comment " : Comment identifier les risques ? Comment analyser les risques ? Quels sont les objectifs de la gestion des risques ? Une carte des risques pour quoi faire ? Pourquoi faut-il financer les risques ? Les entreprises ont-elles des responsabilités pénales ? En quoi consiste la gestion...

  19. Le dialogisme intertextuel des contes des Grimm

    OpenAIRE

    2012-01-01

    « Le caractère le plus important de l’énoncé, ou en tous cas le plus ignoré, est son dialogisme, c’est-à-dire sa dimension intertextuelle », constate Todorov en référence à la conception dialogique du langage proposée par Bakthine. Cet article introductif postule que ce constat s’applique aussi aux contes des Grimm. En partant des recherches déjà menées sur Apulée, Straporola, Basile, Perrault, La Fontaine et Lhéritier, il présente des concepts (réponse intertextuelle, reconfiguration génériq...

  20. Opinion Dynamics with Confirmation Bias

    CERN Document Server

    Allahverdyan, A E

    2014-01-01

    Background: Confirmation bias is the tendency to acquire or evaluate new information in a way that is consistent with one's preexisting beliefs. It is omnipresent in psychology, economics, and even scientific practices. Prior theoretical research of this phenomenon has mainly focused on its economic implications possibly missing its potential connections with broader notions of cognitive science. Methodology/Principal Findings: We formulate a (non-Bayesian) model for revising subjective probabilistic opinion of a confirmationally-biased agent in the light of a persuasive opinion. The revision rule ensures that the agent does not react to persuasion that is either far from his current opinion or coincides with it. We demonstrate that the model accounts for the basic phenomenology of the social judgment theory, and allows to study various phenomena such as cognitive dissonance and boomerang effect. The model also displays the order of presentation effect|when consecutively exposed to two opinions, the preferenc...

  1. Performance Confirmation Data Aquisition System

    Energy Technology Data Exchange (ETDEWEB)

    D.W. Markman

    2000-10-27

    The purpose of this analysis is to identify and analyze concepts for the acquisition of data in support of the Performance Confirmation (PC) program at the potential subsurface nuclear waste repository at Yucca Mountain. The scope and primary objectives of this analysis are to: (1) Review the criteria for design as presented in the Performance Confirmation Data Acquisition/Monitoring System Description Document, by way of the Input Transmittal, Performance Confirmation Input Criteria (CRWMS M&O 1999c). (2) Identify and describe existing and potential new trends in data acquisition system software and hardware that would support the PC plan. The data acquisition software and hardware will support the field instruments and equipment that will be installed for the observation and perimeter drift borehole monitoring, and in-situ monitoring within the emplacement drifts. The exhaust air monitoring requirements will be supported by a data communication network interface with the ventilation monitoring system database. (3) Identify the concepts and features that a data acquisition system should have in order to support the PC process and its activities. (4) Based on PC monitoring needs and available technologies, further develop concepts of a potential data acquisition system network in support of the PC program and the Site Recommendation and License Application.

  2. Opinion dynamics with confirmation bias.

    Science.gov (United States)

    Allahverdyan, Armen E; Galstyan, Aram

    2014-01-01

    Confirmation bias is the tendency to acquire or evaluate new information in a way that is consistent with one's preexisting beliefs. It is omnipresent in psychology, economics, and even scientific practices. Prior theoretical research of this phenomenon has mainly focused on its economic implications possibly missing its potential connections with broader notions of cognitive science. We formulate a (non-Bayesian) model for revising subjective probabilistic opinion of a confirmationally-biased agent in the light of a persuasive opinion. The revision rule ensures that the agent does not react to persuasion that is either far from his current opinion or coincides with it. We demonstrate that the model accounts for the basic phenomenology of the social judgment theory, and allows to study various phenomena such as cognitive dissonance and boomerang effect. The model also displays the order of presentation effect-when consecutively exposed to two opinions, the preference is given to the last opinion (recency) or the first opinion (primacy) -and relates recency to confirmation bias. Finally, we study the model in the case of repeated persuasion and analyze its convergence properties. The standard Bayesian approach to probabilistic opinion revision is inadequate for describing the observed phenomenology of persuasion process. The simple non-Bayesian model proposed here does agree with this phenomenology and is capable of reproducing a spectrum of effects observed in psychology: primacy-recency phenomenon, boomerang effect and cognitive dissonance. We point out several limitations of the model that should motivate its future development.

  3. Opinion dynamics with confirmation bias.

    Directory of Open Access Journals (Sweden)

    Armen E Allahverdyan

    Full Text Available Confirmation bias is the tendency to acquire or evaluate new information in a way that is consistent with one's preexisting beliefs. It is omnipresent in psychology, economics, and even scientific practices. Prior theoretical research of this phenomenon has mainly focused on its economic implications possibly missing its potential connections with broader notions of cognitive science.We formulate a (non-Bayesian model for revising subjective probabilistic opinion of a confirmationally-biased agent in the light of a persuasive opinion. The revision rule ensures that the agent does not react to persuasion that is either far from his current opinion or coincides with it. We demonstrate that the model accounts for the basic phenomenology of the social judgment theory, and allows to study various phenomena such as cognitive dissonance and boomerang effect. The model also displays the order of presentation effect-when consecutively exposed to two opinions, the preference is given to the last opinion (recency or the first opinion (primacy -and relates recency to confirmation bias. Finally, we study the model in the case of repeated persuasion and analyze its convergence properties.The standard Bayesian approach to probabilistic opinion revision is inadequate for describing the observed phenomenology of persuasion process. The simple non-Bayesian model proposed here does agree with this phenomenology and is capable of reproducing a spectrum of effects observed in psychology: primacy-recency phenomenon, boomerang effect and cognitive dissonance. We point out several limitations of the model that should motivate its future development.

  4. Photonique des Morphos

    CERN Document Server

    Berthier, Serge

    2010-01-01

    La photonique est déjà présente dans notre vie quotidienne, et on attend maintenant que la manipulation des photons permette aussi le traitement logique des informations. Cependant, l’élément de base qui permet cette manipulation de la lumière, le cristal photonique, est d’une réalisation complexe et mal contrôlée. Dans la course à la maîtrise de la lumière, les structures photoniques naturelles ont beaucoup à nous apprendre. C’est ce que nous montre Serge Berthier qui étudie dans ce livre la structure des écailles des Morphos. Tenant compte de l’essor récent des approches biomimétiques, il présente de manière détaillée plus de dix-huit techniques expérimentales utilisées pour ses analyses, ainsi que les diverses approches théoriques développées pour la modélisation de structures multi-échelles complexes. Première étude quasi-exhaustive des structures fines d’un genre et des propriétés optiques ainsi que colorimétriques générées, ce livre fournit aux entomologiste...

  5. Droit des organisations internationales

    CERN Document Server

    Sorel, Jean-Marc; Ndior, Valère

    2013-01-01

    Cet ouvrage collectif offre aux enseignants et chercheurs en droit international, aux praticiens et aux étudiants, une analyse actualisée du droit des organisations internationales. Il dresse en cinq parties un tableau, illustré par des exemples variés, des problématiques que soulève le phénomène polymorphe d institutionnalisation de la société internationale. La première partie est consacrée au phénomène des « organisations internationales », sous l angle à la fois de l institutionnalisation progressive des relations internationales et de la difficulté à cerner une catégorie unifiée. La deuxième partie rend compte de la création, de la disparition et des mutations des organisations internationales, ici envisagées comme systèmes institutionnels et ordres juridiques dérivés. La troisième partie analyse l autonomie que l acquisition de la personnalité juridique et de privilèges et immunités, un organe administratif intégré, un personnel ou un budget propres confèrent aux organi...

  6. Opinion Dynamics with Confirmation Bias

    Science.gov (United States)

    Allahverdyan, Armen E.; Galstyan, Aram

    2014-01-01

    Background Confirmation bias is the tendency to acquire or evaluate new information in a way that is consistent with one's preexisting beliefs. It is omnipresent in psychology, economics, and even scientific practices. Prior theoretical research of this phenomenon has mainly focused on its economic implications possibly missing its potential connections with broader notions of cognitive science. Methodology/Principal Findings We formulate a (non-Bayesian) model for revising subjective probabilistic opinion of a confirmationally-biased agent in the light of a persuasive opinion. The revision rule ensures that the agent does not react to persuasion that is either far from his current opinion or coincides with it. We demonstrate that the model accounts for the basic phenomenology of the social judgment theory, and allows to study various phenomena such as cognitive dissonance and boomerang effect. The model also displays the order of presentation effect–when consecutively exposed to two opinions, the preference is given to the last opinion (recency) or the first opinion (primacy) –and relates recency to confirmation bias. Finally, we study the model in the case of repeated persuasion and analyze its convergence properties. Conclusions The standard Bayesian approach to probabilistic opinion revision is inadequate for describing the observed phenomenology of persuasion process. The simple non-Bayesian model proposed here does agree with this phenomenology and is capable of reproducing a spectrum of effects observed in psychology: primacy-recency phenomenon, boomerang effect and cognitive dissonance. We point out several limitations of the model that should motivate its future development. PMID:25007078

  7. Model confirmation in climate economics.

    Science.gov (United States)

    Millner, Antony; McDermott, Thomas K J

    2016-08-01

    Benefit-cost integrated assessment models (BC-IAMs) inform climate policy debates by quantifying the trade-offs between alternative greenhouse gas abatement options. They achieve this by coupling simplified models of the climate system to models of the global economy and the costs and benefits of climate policy. Although these models have provided valuable qualitative insights into the sensitivity of policy trade-offs to different ethical and empirical assumptions, they are increasingly being used to inform the selection of policies in the real world. To the extent that BC-IAMs are used as inputs to policy selection, our confidence in their quantitative outputs must depend on the empirical validity of their modeling assumptions. We have a degree of confidence in climate models both because they have been tested on historical data in hindcasting experiments and because the physical principles they are based on have been empirically confirmed in closely related applications. By contrast, the economic components of BC-IAMs often rely on untestable scenarios, or on structural models that are comparatively untested on relevant time scales. Where possible, an approach to model confirmation similar to that used in climate science could help to build confidence in the economic components of BC-IAMs, or focus attention on which components might need refinement for policy applications. We illustrate the potential benefits of model confirmation exercises by performing a long-run hindcasting experiment with one of the leading BC-IAMs. We show that its model of long-run economic growth-one of its most important economic components-had questionable predictive power over the 20th century.

  8. Confirmation of shutdown cooling effects

    Energy Technology Data Exchange (ETDEWEB)

    Sato, Kotaro, E-mail: ksato@nelted.co.jp; Tabuchi, Masato; Sugimura, Naoki; Tatsumi, Masahiro [Nuclear Engineering, Limited, 1-3-7 Tosabori Nishi-ku, Osaka-shi, Osaka 550-0001 (Japan)

    2015-12-31

    After the Fukushima accidents, all nuclear power plants in Japan have gradually stopped their operations and have long periods of shutdown. During those periods, reactivity of fuels continues to change significantly especially for high-burnup UO{sub 2} fuels and MOX fuels due to radioactive decays. It is necessary to consider these isotopic changes precisely, to predict neutronics characteristics accurately. In this paper, shutdown cooling (SDC) effects of UO{sub 2} and MOX fuels that have unusual operation histories are confirmed by the advanced lattice code, AEGIS. The calculation results show that the effects need to be considered even after nuclear power plants come back to normal operation.

  9. Investigation of the molecular relationship between breast cancer and obesity by candidate gene prioritization methods

    Directory of Open Access Journals (Sweden)

    Saba Garshasbi

    2015-10-01

    Full Text Available Background: Cancer and obesity are two major public health concerns. More than 12 million cases of cancer are reported annually. Many reports confirmed obesity as a risk factor for cancer. The molecular relationship between obesity and breast cancer has not been clear yet. The purpose of this study was to investigate priorities of effective genes in the molecular relationship between obesity and breast cancer. Methods: In this study, computer simulation method was used for prioritizing the genes that involved in the molecular links between obesity and breast cancer in laboratory of systems biology and bioinformatics (LBB, Tehran University, Tehran, Iran, from March to July 2014. In this study, ENDEAVOUR software was used for prioritizing the genes and integrating multiple data sources was used for data analysis. Training genes were selected from effective genes in obesity and/or breast cancer. Two groups of candidate genes were selected. The first group was included the existential genes in 5 common region chromosomes (between obesity and breast cancer and the second group was included the results of genes microarray data analysis of research Creighton, et al (In 2012 on patients with breast cancer. The microarray data were analyzed with GER2 software (R online software on GEO website. Finally, both training and candidate genes were entered in ENDEAVOUR software package. Results: The candidate genes were prioritized to four style and five genes in ten of the first priorities were repeated twice. In other word, the outcome of prioritizing of 72 genes (Product of microarray data analysis and genes of 5 common chromosome regions (Between obesity and breast cancer showed, 5 genes (TNFRSF10B, F2, IGFALS, NTRK3 and HSP90B1 were the priorities in the molecular connection between obesity and breast cancer. Conclusion: There are some common genes between breast cancer and obesity. So, molecular relationship is confirmed. In this study the possible effect

  10. Prioritization of Disease Susceptibility Genes Using LSM/SVD.

    Science.gov (United States)

    Gong, Lejun; Yang, Ronggen; Yan, Qin; Sun, Xiao

    2013-12-01

    Understanding the role of genetics in diseases is one of the most important tasks in the postgenome era. It is generally too expensive and time consuming to perform experimental validation for all candidate genes related to disease. Computational methods play important roles for prioritizing these candidates. Herein, we propose an approach to prioritize disease genes using latent semantic mapping based on singular value decomposition. Our hypothesis is that similar functional genes are likely to cause similar diseases. Measuring the functional similarity between known disease susceptibility genes and unknown genes is to predict new disease susceptibility genes. Taking autism as an instance, the analysis results of the top ten genes prioritized demonstrate they might be autism susceptibility genes, which also indicates our approach could discover new disease susceptibility genes. The novel approach of disease gene prioritization could discover new disease susceptibility genes, and latent disease-gene relations. The prioritized results could also support the interpretive diversity and experimental views as computational evidence for disease researchers.

  11. RePizer:a framework for prioritization of software requirements

    Institute of Scientific and Technical Information of China (English)

    Saif Ur Rehman KHAN; Sai Peck LEE; Mohammad DABBAGH; Muhammad TAHIR; Muzafar KHAN; Muhammad ARIF

    2016-01-01

    The standard software development life cycle heavily depends on requirements elicited from stakeholders. Based on those requirements, software development is planned and managed from its inception phase to closure. Due to time and resource constraints, it is imperative to identify the high-priority requirements that need to be considered first during the software devel-opment process. Moreover, existing prioritization frameworks lack a store of historical data useful for selecting the most suitable prioritization technique of any similar project domain. In this paper, we propose a framework for prioritization of software re-quirements, called RePizer, to be used in conjunction with a selected prioritization technique to rank software requirements based on defined criteria such as implementation cost. RePizer assists requirements engineers in a decision-making process by retrieving historical data from a requirements repository. RePizer also provides a panoramic view of the entire project to ensure the judicious use of software development resources. We compared the performance of RePizer in terms of expected accuracy and ease of use while separately adopting two different prioritization techniques, planning game (PG) and analytical hierarchy process (AHP). The results showed that RePizer performed better when used in conjunction with the PG technique.

  12. Consequence Prioritization Process for Potential High Consequence Events (HCE)

    Energy Technology Data Exchange (ETDEWEB)

    Freeman, Sarah G. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-10-31

    This document describes the process for Consequence Prioritization, the first phase of the Consequence-Driven Cyber-Informed Engineering (CCE) framework. The primary goal of Consequence Prioritization is to identify potential disruptive events that would significantly inhibit an organization’s ability to provide the critical services and functions deemed fundamental to their business mission. These disruptive events, defined as High Consequence Events (HCE), include both events that have occurred or could be realized through an attack of critical infrastructure owner assets. While other efforts have been initiated to identify and mitigate disruptive events at the national security level, such as Presidential Policy Directive 41 (PPD-41), this process is intended to be used by individual organizations to evaluate events that fall below the threshold for a national security. Described another way, Consequence Prioritization considers threats greater than those addressable by standard cyber-hygiene and includes the consideration of events that go beyond a traditional continuity of operations (COOP) perspective. Finally, Consequence Prioritization is most successful when organizations adopt a multi-disciplinary approach, engaging both cyber security and engineering expertise, as in-depth engineering perspectives are required to recognize and characterize and mitigate HCEs. Figure 1 provides a high-level overview of the prioritization process.

  13. Modeling confirmation bias and polarization

    CERN Document Server

    Del Vicario, Michela; Caldarelli, Guido; Stanley, H Eugene; Quattrociocchi, Walter

    2016-01-01

    Online users tend to select claims that adhere to their system of beliefs and to ignore dissenting information. Confirmation bias, indeed, plays a pivotal role in viral phenomena. Furthermore, the wide availability of content on the web fosters the aggregation of likeminded people where debates tend to enforce group polarization. Such a configuration might alter the public debate and thus the formation of the public opinion. In this paper we provide a mathematical model to study online social debates and the related polarization dynamics. We assume the basic updating rule of the Bounded Confidence Model (BCM) and we develop two variations a) the Rewire with Bounded Confidence Model (RBCM), in which discordant links are broken until convergence is reached; and b) the Unbounded Confidence Model, under which the interaction among discordant pairs of users is allowed even with a negative feedback, either with the rewiring step (RUCM) or without it (UCM). From numerical simulations we find that the new models (UCM...

  14. Dental Encounter System (DES)

    Data.gov (United States)

    Department of Veterans Affairs — Dental Encounter System (DES) is an automated health care application designed to capture critical data about the operations of VA Dental Services. Information on...

  15. Table des illustrations

    OpenAIRE

    2016-01-01

    Tableaux Dates d’inauguration des grands hôtels japonais entre 1860 et 1945… 19 Histoire, tourisme et hôtellerie en Corée depuis les années 1870… 59-60 Dates d’inauguration des grands hôtels chinois depuis 1863… 84 Les hôtels de luxe et leurs capacités d’hébergement en Corée en 2000… 103 Les flux de personnes suscités par les hôtels « super luxe » de Séoul en 2000… 105 L’activité des grands hôtels à Séoul en 1999 (en wons)… 106 Propriété et gestion des grands hôtels à Séoul en 1999…. 110 La c...

  16. Chimie des processus biologiques

    OpenAIRE

    Fontecave, Marc

    2010-01-01

    La chimie du vivant : enzymes et métalloenzymes, des biocatalyseurs fascinants La catalyse enzymatique, ce pouvoir que possèdent certaines protéines d’accélérer de façon extraordinaire et d’orienter avec une précision fascinante les réactions chimiques de la cellule, reste, encore aujourd’hui, l’un des grands mystères des systèmes vivants. Les réactions dont il est question vont de la simple hydrolyse de liaisons peptidiques à des processus poly-électroniques d’une très grande complexité, com...

  17. Prioritizing positivity: an effective approach to pursuing happiness?

    Science.gov (United States)

    Catalino, Lahnna I; Algoe, Sara B; Fredrickson, Barbara L

    2014-12-01

    A decade of research reveals the benefits of positive emotions for mental and physical health; however, recent empirical work suggests the explicit pursuit of happiness may backfire. The present study hypothesized that the pursuit of happiness is not inherently self-defeating; in particular, individuals who seek positivity, as exemplified by how they make decisions about how to organize their day-to-day lives, may be happier. This individual difference is labeled prioritizing positivity. In a community sample of young to older adults (N = 233), prioritizing positivity predicted a host of well-being outcomes (positive emotions, depressive symptomology). In addition, people high in prioritizing positivity have greater resources, and these links are explained by more frequent experiences of positive emotions. In sum, the present study suggests that seeking happiness, although a delicate art, may be a worthwhile pursuit.

  18. Prioritizing Positivity: An Effective Approach to Pursuing Happiness?

    Science.gov (United States)

    Catalino, Lahnna I.; Algoe, Sara B.; Fredrickson, Barbara L.

    2017-01-01

    A decade of research reveals the benefits of positive emotions for mental and physical health; however, recent empirical work suggests the explicit pursuit of happiness may backfire. The present study hypothesized that the pursuit of happiness is not inherently self-defeating; in particular, individuals who seek positivity, as exemplified by how they make decisions about how to organize their day-to-day lives, may be happier. This individual difference is labeled prioritizing positivity. In a community sample of young to older adults (N = 233), prioritizing positivity predicted a host of well-being outcomes (positive emotions, depressive symptomology). In addition, people high in prioritizing positivity have greater resources, and these links are explained by more frequent experiences of positive emotions. In sum, the present study suggests that seeking happiness, although a delicate art, may be a worthwhile pursuit. PMID:25401290

  19. Scientists' Prioritization of Communication Objectives for Public Engagement.

    Science.gov (United States)

    Dudo, Anthony; Besley, John C

    2016-01-01

    Amid calls from scientific leaders for their colleagues to become more effective public communicators, this study examines the objectives that scientists' report drive their public engagement behaviors. We explore how scientists evaluate five specific communication objectives, which include informing the public about science, exciting the public about science, strengthening the public's trust in science, tailoring messages about science, and defending science from misinformation. We use insights from extant research, the theory of planned behavior, and procedural justice theory to identify likely predictors of scientists' views about these communication objectives. Results show that scientists most prioritize communication designed to defend science from misinformation and educate the public about science, and least prioritize communication that seeks to build trust and establish resonance with the public. Regression analyses reveal factors associated with scientists who prioritize each of the five specific communication objectives. Our findings highlight the need for communication trainers to help scientists select specific communication objectives for particular contexts and audiences.

  20. Gene Prioritization by Compressive Data Fusion and Chaining.

    Directory of Open Access Journals (Sweden)

    Marinka Žitnik

    2015-10-01

    Full Text Available Data integration procedures combine heterogeneous data sets into predictive models, but they are limited to data explicitly related to the target object type, such as genes. Collage is a new data fusion approach to gene prioritization. It considers data sets of various association levels with the prediction task, utilizes collective matrix factorization to compress the data, and chaining to relate different object types contained in a data compendium. Collage prioritizes genes based on their similarity to several seed genes. We tested Collage by prioritizing bacterial response genes in Dictyostelium as a novel model system for prokaryote-eukaryote interactions. Using 4 seed genes and 14 data sets, only one of which was directly related to the bacterial response, Collage proposed 8 candidate genes that were readily validated as necessary for the response of Dictyostelium to Gram-negative bacteria. These findings establish Collage as a method for inferring biological knowledge from the integration of heterogeneous and coarsely related data sets.

  1. Vom Ort des Philosophierens

    OpenAIRE

    Damir Barbaric

    2002-01-01

    Im Aufsatz wird versucht, den ursprünglichen Sinn der Platonischen Bestimmung vom Staunen als Anfang der Philosophie zu ermitteln, und zwar durch eine kritischen Abhebung von ihrer Umdeutung bei Aristoteles, und dann insbesondere in der Stoa wie auch bei Spinoza und Hegel. Dabei wird auf die frühgriechische Erfahrung vom Staunen als _______ aufmerksam gemacht, wo es vor allem die Grundstimmung des Dabeiseins des Göttlichen und der menschlichen Teilnahme am Göttlichen bedeutet. Dem entspricht ...

  2. Liste des auteurs

    OpenAIRE

    2015-01-01

    Fariba Adelkhah est chargée de recherche à la Fondation nationale des sciences politiques, Centre d’études et de recherches internationales (CERI) [] Jean-Marie Bouissou est chargé de recherche à la Fondation nationale des sciences politiques, Centre d’études et de recherches internationales (CERI) [] Jean-Louis Briquet est chargé de recherche au CNRS, Centre d’études et de recherches internationales (CERI) [...

  3. Peste des petits ruminants in Arabian wildlife.

    Science.gov (United States)

    Kinne, J; Kreutzer, R; Kreutzer, M; Wernery, U; Wohlsein, P

    2010-08-01

    Recurrence of peste des petits ruminants (PPR) was diagnosed in the United Arabian Emirates in several wild ruminants confirmed by morphological, immunohistochemical, serological and molecular findings. Phylogenetic analysis revealed that the virus strain belongs to lineage IV, which is different to some previously isolated PPR strains from the Arabian Peninsula. This study shows that wild ruminants may play an important epidemiological role as virus source for domestic small ruminants.

  4. La revolution des savants

    CERN Document Server

    Chavanne, A

    1989-01-01

    Premiere cassette : - 1666 : impact de la creation de l'Academie des Sciences par Colbert, trente ans apres le proces de Galile, et au moment des disparitions de Pascal, Descartes et Fermat. Elle dirigee par le hollandais Huyggens jusqu'a sa fuite de France au moment de la revocation de l'Edit de Nantes. - 1750 : l'Encyclopedie (ou "Dictionnaire raisonne des Sciences, des Arts et des Metiers") de Diderot et d'Alembert, soutenus par Malherbes, Buffon, Condorcet et Rousseau. - 1789 : Revolution francaise. - 8 aout 1793 : l'Assemblee, par une declaration de Marat, dissout l'Academie des Sciences. Celle-ci continue cependant ses travaux pour les poids et mesures jusqu'en 1795. - la Terreur : la condamnation a mort, pas au nom d'une "Revolution qui n'a pas besoin de savants" mais pour d'autres raisons, de trois grands hommes de science : Lavoisier, Bailly et Condorcet. - 1793-1794 : Au printemps 93, le Comite de Salut Publique s'inquiete du demi-million de soldats etrangers de toutes les pays frontaliers qui essai...

  5. Research to Inform Nutrient Thresholds and Prioritization of ...

    Science.gov (United States)

    The information in this presentation focuses on SSWR's 4.02 project, which will advance the science needed to inform decisions to prioritize watersheds and nutrient sources for nutrient management and define appropriate nutrient levels for the nation’s waters, two important elements of EPA’s framework for managing nutrient pollution. The information in this presentation focuses on SSWR's 4.02 project, which will advance the science needed to inform decisions to prioritize watersheds and nutrient sources for nutrient management and define appropriate nutrient levels for the nation’s waters, two important elements of EPA’s framework for managing nutrient pollution.

  6. Modeling confirmation bias and polarization

    Science.gov (United States)

    Del Vicario, Michela; Scala, Antonio; Caldarelli, Guido; Stanley, H. Eugene; Quattrociocchi, Walter

    2017-01-01

    Online users tend to select claims that adhere to their system of beliefs and to ignore dissenting information. Confirmation bias, indeed, plays a pivotal role in viral phenomena. Furthermore, the wide availability of content on the web fosters the aggregation of likeminded people where debates tend to enforce group polarization. Such a configuration might alter the public debate and thus the formation of the public opinion. In this paper we provide a mathematical model to study online social debates and the related polarization dynamics. We assume the basic updating rule of the Bounded Confidence Model (BCM) and we develop two variations a) the Rewire with Bounded Confidence Model (RBCM), in which discordant links are broken until convergence is reached; and b) the Unbounded Confidence Model, under which the interaction among discordant pairs of users is allowed even with a negative feedback, either with the rewiring step (RUCM) or without it (UCM). From numerical simulations we find that the new models (UCM and RUCM), unlike the BCM, are able to explain the coexistence of two stable final opinions, often observed in reality. Lastly, we present a mean field approximation of the newly introduced models. PMID:28074874

  7. Modeling confirmation bias and polarization

    Science.gov (United States)

    Del Vicario, Michela; Scala, Antonio; Caldarelli, Guido; Stanley, H. Eugene; Quattrociocchi, Walter

    2017-01-01

    Online users tend to select claims that adhere to their system of beliefs and to ignore dissenting information. Confirmation bias, indeed, plays a pivotal role in viral phenomena. Furthermore, the wide availability of content on the web fosters the aggregation of likeminded people where debates tend to enforce group polarization. Such a configuration might alter the public debate and thus the formation of the public opinion. In this paper we provide a mathematical model to study online social debates and the related polarization dynamics. We assume the basic updating rule of the Bounded Confidence Model (BCM) and we develop two variations a) the Rewire with Bounded Confidence Model (RBCM), in which discordant links are broken until convergence is reached; and b) the Unbounded Confidence Model, under which the interaction among discordant pairs of users is allowed even with a negative feedback, either with the rewiring step (RUCM) or without it (UCM). From numerical simulations we find that the new models (UCM and RUCM), unlike the BCM, are able to explain the coexistence of two stable final opinions, often observed in reality. Lastly, we present a mean field approximation of the newly introduced models.

  8. Performance confirmation data acquisition system

    Energy Technology Data Exchange (ETDEWEB)

    McAffee, D.A.; Raczka, N.T. [Yucca Mountain Project, Las Vegas, NV (United States)

    1997-12-31

    As part of the Viability Assessment (VA) work, this QAP-3-9 document presents and evaluates a comprehensive set of viable concepts for collecting Performance Confirmation (PC) related data. The concepts include: monitoring subsurface repository air temperatures, humidity levels and gaseous emissions via the subsurface ventilation systems, and monitoring the repository geo-technical parameters and rock mass from bore-holes located along the perimeter main drifts and throughout a series of human-rated Observation Drifts to be located in a plane 25 meters above the plane of the emplacement drifts. A key element of this document is the development and analysis of a purposed multi-purpose Remote Inspection Gantry that would provide direct, real-time visual, thermal, and radiological monitoring of conditions inside operational emplacement drifts and close-up observations of in-situ Waste Packages. Preliminary finite-element analyses are presented that indicate the technological feasibility of operating an inspection gantry inside the operational emplacement drifts for short inspection missions lasting 2--3 hours. Overall reliability, availability, and maintainability of the PC data collection concepts are discussed. Preliminary concepts for PC data collection network are also provided.

  9. Le dialogisme intertextuel des contes des Grimm

    OpenAIRE

    2013-01-01

    Loin d'être « purement allemands », nombre de contes des Grimm réécrivent les contes français largement diffusés en Allemagne au XVIIIe siècle en les « reconfigurant » selon leurs propres paradigmes esthétiques et idéologiques. L'étude introductive de la comparatiste Ute Heidmann montre que ce dialogisme européen est resté peu exploré en raison d’une « scénographie en trompe-l’œil » qui les présente comme issus du « terroir » hessois. Toutefois, les notes des Grimm (constituées en volume auto...

  10. Maladie des vibrations

    Science.gov (United States)

    Shen, Shixin (Cindy); House, Ronald A.

    2017-01-01

    Résumé Objectif Permettre aux médecins de famille de comprendre l’épidémiologie, la pathogenèse, les symptômes, le diagnostic et la prise en charge de la maladie des vibrations, une maladie professionnelle importante et courante au Canada. Sources d’information Une recherche a été effectuée sur MEDLINE afin de relever les recherches et comptes rendus portant sur la maladie des vibrations. Une recherche a été effectuée sur Google dans le but d’obtenir la littérature grise qui convient au contexte canadien. D’autres références ont été tirées des articles relevés. Message principal La maladie des vibrations est une maladie professionnelle répandue touchant les travailleurs de diverses industries qui utilisent des outils vibrants. La maladie est cependant sous-diagnostiquée au Canada. Elle compte 3 éléments : vasculaire, sous la forme d’un phénomène de Raynaud secondaire; neurosensoriel; et musculosquelettique. Aux stades les plus avancés, la maladie des vibrations entraîne une invalidité importante et une piètre qualité de vie. Son diagnostic exige une anamnèse minutieuse, en particulier des antécédents professionnels, un examen physique, des analyses de laboratoire afin d’éliminer les autres diagnostics, et la recommandation en médecine du travail aux fins d’investigations plus poussées. La prise en charge consiste à réduire l’exposition aux vibrations, éviter les températures froides, abandonner le tabac et administrer des médicaments. Conclusion Pour assurer un diagnostic rapide de la maladie des vibrations et améliorer le pronostic et la qualité de vie, les médecins de famille devraient connaître cette maladie professionnelle courante, et pouvoir obtenir les détails pertinents durant l’anamnèse, recommander les patients aux cliniques de médecine du travail et débuter les demandes d’indemnisation de manière appropriée. PMID:28292812

  11. La convergence des rôles respectifs des relationnistes et des journalistes influence-t-elle la perception qu'ils ont les uns des autres?

    DEFF Research Database (Denmark)

    Valentini, Chiara

    2017-01-01

    la convergence des rôles respectifs des praticiens des relations publiques et des journalistes a un effet favorable sur la perception qu’ils ont les uns des autres. L’effet est plus marqué chez les praticiens des relations publiques, car leur vision de la profession en journalisme correspond à celle...

  12. À propos des occasionnalismes

    Directory of Open Access Journals (Sweden)

    Dal Georgette

    2016-01-01

    Full Text Available Les occasionnalismes (nonce formations ou contextual formations dans la terminologie anglo-saxonne, qu’on définira provisoirement comme de “new complex word[s] created by a speaker/writer on the spur of the moment to cover some immediate need” (Bauer, 1983 : 45 ont, à notre connaissance, peu retenu l’attention des morphologues du domaine francophone. Pourtant, toutes les conditions sont désormais réunies pour que cet objet, invisible lorsqu’il s’agissait de décrire le système morphologique du français (ou d’autres langues à partir de ressources dictionnairiques, émerge en tant qu’observable dans une morphologie puisant ses données dans le réel langagier des locuteurs. Par définition en effet, on s’attend à ce qu’un occasionalisme soit absent des dictionnaires (nous verrons que, dans les faits, la situation est plus complexe que cela, et que ces contextual formations ne puissent pas être étudiées en dehors du contexte dans lequel elles ont été produites. À cet égard, la Toile et les produits qui en dérivent constituent des ressources de choix. C’est particulièrement vrai des forums, dans lesquels les internautes s’expriment librement, laissant libre cours à leur potentiel créatif (ou ce qu’ils pensent tel. Dans la présente communication, après avoir défini la notion d’occasionalisme, nous utiliserons un corpus constitué au fil d’autres recherches pour dégager des motifs récurrents propices à leur apparition, autrement dit pour établir une grammaire des occasionnalismes.

  13. Separation and confirmation of showers

    Science.gov (United States)

    Neslušan, L.; Hajduková, M.

    2017-01-01

    Aims: Using IAU MDC photographic, IAU MDC CAMS video, SonotaCo video, and EDMOND video databases, we aim to separate all provable annual meteor showers from each of these databases. We intend to reveal the problems inherent in this procedure and answer the question whether the databases are complete and the methods of separation used are reliable. We aim to evaluate the statistical significance of each separated shower. In this respect, we intend to give a list of reliably separated showers rather than a list of the maximum possible number of showers. Methods: To separate the showers, we simultaneously used two methods. The use of two methods enables us to compare their results, and this can indicate the reliability of the methods. To evaluate the statistical significance, we suggest a new method based on the ideas of the break-point method. Results: We give a compilation of the showers from all four databases using both methods. Using the first (second) method, we separated 107 (133) showers, which are in at least one of the databases used. These relatively low numbers are a consequence of discarding any candidate shower with a poor statistical significance. Most of the separated showers were identified as meteor showers from the IAU MDC list of all showers. Many of them were identified as several of the showers in the list. This proves that many showers have been named multiple times with different names. Conclusions: At present, a prevailing share of existing annual showers can be found in the data and confirmed when we use a combination of results from large databases. However, to gain a complete list of showers, we need more-complete meteor databases than the most extensive databases currently are. We also still need a more sophisticated method to separate showers and evaluate their statistical significance. Tables A.1 and A.2 are also available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc

  14. Adaptation du modèle SCOR pour la spécificité des PMEs Marocaines : Etude de cas

    OpenAIRE

    LEMGHARI, RADOUANE; SARSRI, DRISS; OKAR, Chafik

    2015-01-01

    International audience; L'évaluation d'une chaine logistique est une des priorités majeures des entreprises, une tâche qui demeure difficile étant donnée la complexité de ces systèmes [1]. Cette évaluation passe par une sélection des indicateurs de mesure de la performance appropriés à la gestion de cette chaine. Il est alors nécessaire d'avoir une démarche structurée et des outils méthodologiques adéquats [2]. Dans ce contexte, on propose dans ce papier une méthode pratique qui permettra, da...

  15. Etude des systèmes protoplanétaires

    Science.gov (United States)

    Augereau, Jean-Charles

    2000-11-01

    Les disques de poussières et de gaz autour des étoiles rejoignant la Séquence Principale sont les sites de formation des planètes extra-solaires dont l'existence s'est vu confirmée récemment. Cette thèse aborde l'étude de la poussière des environnements circumstellaires. Elle associe des observations spatiales à haute résolution angulaire, la modélisation des propriétés physico-chimiques des poussières et leur comportement optique, la modélisation des disques optiquement fins et la dynamique des planétésimaux à l'origine des grains observés autour des étoiles âgées. Les images obtenues avec le Télescope Spatial Hubble révèlent deux nouveaux disques circumstellaires autour des étoiles HD 141569 et HD 100546, parfois classées dans la catégorie des étoiles de Herbig. Bien que les systèmes présentent des âges proches (~10 millions d'années), les morphologies très différentes des disques mettent en évidence la difficulté pour élaborer un scénario unique d'évolution des systèmes protoplanétaires. L'anneau fin de poussières autour de HR 4796A, une étoile d'âge similaire aux précédentes, est marginalement résolu depuis le sol. La modélisation complète de ce disque permet de reproduire l'ensemble des observations disponibles. Ces résultats impliquent la présence de planétésimaux, à un âge aussi peu avancé, pour repeupler le disque en poussières poreuses et essentiellement amorphes qui sont soufflées par la pression de radiation. Une modélisation dynamique du prototypique disque autour de β Pictoris est proposée. Associée à une description réaliste du comportement optique des grains, cette approche reproduit les caractéristiques générales du disque ainsi que des asymétries plus fines en supposant la présence d'une planète dans un disque de planétésimaux et en tenant compte des effets différentiels de la pression de radiation sur les grains. Enfin, le modèle de disques que j'ai développé est exploit

  16. Prioritizing substitution of organic solvents in industrial cleaning processes

    DEFF Research Database (Denmark)

    Rasmussen, Pia Brunn; Jacobsen, Thomas

    1997-01-01

    A method for prioritizing the substitution of volatile organic compounds (VOC) used in industrial cleaning processes is developed. The result is a matrix, which, if all information can be obtained, gives a comprehensive description of the effects, exposure and emission of VOC, as well...

  17. Modelling and Prioritization of System Risks in Early Project Phases

    NARCIS (Netherlands)

    Rajabali Nejad, Mohammadreza

    2016-01-01

    The rising complexity of product and systems demands further attention to potential Risks. While researchers explore tools and methods to identify system risk, its prioritization remains a challenging task in a multistakeholder environment. Hazard is the source of risk and causes harm. Harm may have

  18. An expert system for automated flavour matching - Prioritizer

    DEFF Research Database (Denmark)

    Silva, Bárbara Santos; Tøstesen, Marie; Petersen, Mikael Agerlin

    2017-01-01

    Flavour matching can be viewed as trying to reproduce a specific flavour. This is a time consuming task and may lead to flavour mixtures that are too complex or too expensive to be commercialized. In order to facilitate the matching, we have developed a new mathematical model, called Prioritizer....

  19. Informing watershed connectivity barrier prioritization decisions: A synthesis

    Science.gov (United States)

    McKay, S. K.; Cooper, A. R.; Diebel, M.W.; Elkins, D.; Oldford, G.; Roghair, C.; Wieferich, Daniel J.

    2017-01-01

    Water resources and transportation infrastructure such as dams and culverts provide countless socio-economic benefits; however, this infrastructure can also disconnect the movement of organisms, sediment, and water through river ecosystems. Trade-offs associated with these competing costs and benefits occur globally, with applications in barrier addition (e.g. dam and road construction), reengineering (e.g. culvert repair), and removal (e.g. dam removal and aging infrastructure). Barrier prioritization provides a unique opportunity to: (i) restore and reconnect potentially large habitat patches quickly and effectively and (ii) avoid impacts prior to occurrence in line with the mitigation hierarchy (i.e. avoid then minimize then mitigate). This paper synthesizes 46 watershed-scale barrier planning studies and presents a procedure to guide barrier prioritization associated with connectivity for aquatic organisms. We focus on practical issues informing prioritization studies such as available data sets, methods, techniques, and tools. We conclude with a discussion of emerging trends and issues in barrier prioritization and key opportunities for enhancing the body of knowledge.

  20. A Framework for Event Prioritization in Cyber Network Defense

    Science.gov (United States)

    2014-07-15

    myong H. KAng Jim Z. Luo ALex VeLAZqueZ Center for High Assurance Computer Systems Information Technology Division July 15, 2014 Approved for public...OF ABSTRACT A Framework for Event Prioritization in Cyber Network Defense Anya Kim, Myong H. Kang, Jim Z. Luo, and Alex Velazquez Naval Research

  1. Prioritization Methodology for Development of Required Operational Capabilities

    Science.gov (United States)

    2010-04-01

    Cours d’économie politique professé à l’université de Lausanne, 3 vol., 1896-7. 4 Pareto, V., (1935), The Mind and Society [Trattato Di Sociologia ...and Applications: A State-of-the- Art Survey, Springer-Verlag, New York. Prioritization Methodology for Development of Required Operational

  2. Des Vents et des Jets Astrophysiques

    Science.gov (United States)

    Sauty, C.

    well expected result from the theory. Although, collimation may be conical, paraboloidal or cylindrical (Part 4), cylindrical collimation is the more likely to occur. The shape of outflows may then be used as a tool to predict physical conditions on the flows or on their source. L'éjection continue de plasma autour d'objets massifs est un phénomène largement répandu en astrophysique, que ce soit sous la forme du vent solaire, de vents stellaires, de jets d'étoiles en formation, de jets stellaires autour d'objets compacts ou de jets extra-galactiques. Cette zoologie diversifiée fait pourtant l'objet d'un commun effort de modélisation. Le but de cette revue est d'abord de présenter qualitativement le développement, depuis leur origine, des diverses théories de vents (Partie 1) et l'inter disciplinarité dans ce domaine. Il s'agit d'une énumération, plus ou moins exhaustive, des idées proposées pour expliquer l'accélération et la morphologie des vents et des jets, accompagnée d'une présentation sommaire des aspects observationnels. Cette partie s'abstient de tout aspect faisant appel au formalisme mathématique. Ces écoulements peuvent être décrits, au moins partiellement, en résolvant les équations magnétohydrodynamiques, axisymétriques et stationnaires. Ce formalisme, à la base de la plupart des théories, est exposé dans la Partie 2. Il permet d'introduire quantitativement les intégrales premières qu'un tel système possède. Ces dernières sont amenées à jouer un rôle important dans la compréhension des phénomènes d'accélération ou de collimation, en particulier le taux de perte de masse, le taux de perte de moment angulaire ou l'énergie du rotateur magnétique. La difficulté de modélisation réside dans l'existence de points critiques, propres aux équations non linéaires, qu'il faut franchir. La nature physique et la localisation de ces points critiques fait l'objet d'un débat important car ils sont la clef de voute de la r

  3. L'intégration des accélérateurs du CERN

    CERN Document Server

    Chemli, S; CERN. Geneva. TS Department

    2008-01-01

    L?intégration du LHC a ouvert des perspectives pour une gestion plus complète des accélérateurs du CERN. La base de données LAYOUT a permis d'assurer la continuité des phases de définition optique du projet, d'intégration 3D et de contrôles de conformité des installations. Les scans et modélisations 3D en couches des installations réalisées constituent un outil déterminant pour la préparation des interventions dans le cadre des procédures de sécurité ALARA. Il est proposé de reproduire cette méthodologie pour les nouveaux projets comme pour les accélérateurs existants. La mise à jour de l'anneau SPS dans LAYOUT semble être la priorité. La base de données SURVEY contient déjà une vue d'ensemble des accélérateurs, chaque composant étant référencé dans le Système de Coordonnées du CERN, selon les définitions théoriques "sources" au 1/100 mm. Base pour l'alignement, elle stocke également les positions réelles des machines. Elle complète ainsi l'information linéaire de LAY...

  4. Table des illustrations

    OpenAIRE

    2015-01-01

    Intégrer les Tsiganes Hongrie, 1970 (photo DR) 34 Discuter entretient la fraternité. (photo M. Stewart) 35 La veille du mariage (photo M. Stewart) 36 Le « salon » (photo M. Stewart) 37 Les activités économiques des Tsiganes sont conçues comme des jeux. (photo M. Stewart) 39 Lev cheval (photo I. Nemeth) 41 Le cortège d’un mariage (photo M. Stewart) 43 Avant le mariage (photo M. Stewart) 43 C’est par le chant (photo M. Stewart) 45 Des « frères » boivent en harmonie (photo M. Stewart) 46 Les che...

  5. Geschichte des SIN

    CERN Document Server

    Pritzker, Andreas

    2013-01-01

    Dieses Buch erzählt die Geschichte des Schweizerischen Instituts für Nuklearforschung (SIN). Das Institut wurde 1968 gegründet und ging 1988 ins Paul Scherrer Institut (PSI) über. Die Gründung des SIN erfolgte in einer Zeit, als die Physik weitherum als Schlüsseldisziplin für die technologische und gesellschaftliche Entwicklung galt. Der Schritt war für ein kleines Land wie die Schweiz ungewöhnliche und zeugte von Mut und Weitsicht. Ungewöhnlich waren der Folge die Leistungen des SIN im weltweiten Vergleich sowie sein Einfluss auf die schweizerische, teils auf die internationale Wissenschaftspolitik.

  6. Les lueurs des sables

    CERN Multimedia

    Les lueurs des sables

    2013-01-01

    Two CERN ladies are getting ready for the “Trophée Roses des Sables” rally adventure: Julie and Laetitia are finalizing the last details before setting off on Monday 7th October 2013. Julie from EN-MEF group and Laetitia from DGS-SEE group, met at the CERN Rugby club. This year, they are participating in the 100 % female rally which will take place in Morocco from 10 to 20 October. They will be carrying along 100 kg of humanitarian donation for children such as some clothes, books and medical material. Do not hesitate to show your support at their farewell party to be held on Monday 7 October, from 4 to 6 pm in front of the St Genis-Pouilly Mairie (city Hall). Follow their exciting adventure on the blog leslueursdessables.trophee-roses-des-sables.org and on their association’s Facebook page Les Lueurs des Sables.

  7. Des Groupes et des Œuvres

    OpenAIRE

    Grojnowski, Daniel

    2015-01-01

    À la fin du xixe siècle, les groupes de bohèmes se multiplient et se diversifient, des salons privés aux tavernes ou cabarets. Une étude aussi attentive que possible de trois d’entre eux (les Zutiques, les Hydropathes, les Incohérents) montre la diversité de leurs configurations, ainsi que l’importance déterminante que leurs productions revêt au regard de la postérité.

  8. Differentialdiagnose des Ulcus cruris

    Directory of Open Access Journals (Sweden)

    Binder B

    2010-01-01

    Full Text Available Das Ulcus cruris ist eine Erkrankung vor allem des höheren Lebensalters. Ungefähr 1 % der Bevölkerung leidet an einer chronischen Wunde. An die 90 % der Ulzera sind vaskulärer Genese, doch gibt es vielfältige weitere Ursachen. Die Kenntnis der relevanten Differentialdiagnosen ist insbesondere bei therapierefraktären Verläufen von Bedeutung. Dazu gehören Neuropathien, myeloproliferative Erkrankungen, Infektionen, Medikamente oder Hauttumore. Für eine erfolgreiche Behandlung des Ulcus cruris ist die Identifikation der Genese von entscheidender Bedeutung, um eine kausale, interdisziplinäre Therapie zu ermöglichen.

  9. Liste des Auteurs

    OpenAIRE

    2014-01-01

    Amor Hakima, Université Cadi Ayyad, Faculté des sciences Semlalia, Département de biologie, Laboratoire d’écologie humaine, Marrakech, Maroc. Angeli Aurora, Universita degli studi di Bologna, Dipartimento di scienze statiche “Paolo Fortunati”, Bologne, Italie. Baali Abdellatif, Université Cadi Ayyad, Faculté des sciences Semlalia, Département de biologie, Laboratoire d’écologie humaine, Marrakech, Maroc. Bachtarzi T., Hôpital Ibn Sina, CHU Annaba, Algérie. Baudot Patrick, Université de Proven...

  10. Liste des Auteurs

    OpenAIRE

    2014-01-01

    Amor Hakima, Université Cadi Ayyad, Faculté des sciences Semlalia, Département de biologie, Laboratoire d’écologie humaine, Marrakech, Maroc. Angeli Aurora, Universita degli studi di Bologna, Dipartimento di scienze statiche “Paolo Fortunati”, Bologne, Italie. Baali Abdellatif, Université Cadi Ayyad, Faculté des sciences Semlalia, Département de biologie, Laboratoire d’écologie humaine, Marrakech, Maroc. Bachtarzi T., Hôpital Ibn Sina, CHU Annaba, Algérie. Baudot Patrick, Université de Proven...

  11. Ageing Mechanisms and Control. Specialists’ Meeting on Life Management Techniques for Ageing Air Vehicles (Les mecanismes vieillissants et le controle) (Reunions des specialistes des techniques de gestion du cycle de vie pour vehicules aeriens vieillissants)

    Science.gov (United States)

    2003-02-01

    développement et la mise en œuvre de technologies nouvelles/existantes, ainsi que de processus de gestion de la logistique , permettant l’établissement...technologies existantes et nouvelles, ainsi que des processus de gestion de la logistique . Ils seront alors plus à même de déterminer leurs priorités en

  12. Consequences for diversity when prioritizing animals for conservation with pedigree or genomic information

    NARCIS (Netherlands)

    Engelsma, K.A.; Veerkamp, R.F.; Calus, M.P.L.; Windig, J.J.

    2011-01-01

    Up to now, prioritization of animals for conservation has been mainly based on pedigree information; however, genomic information may improve prioritization. In this study, we used two Holstein populations to investigate the consequences for genetic diversity when animals are prioritized with

  13. Die lebensvision des semonides

    Directory of Open Access Journals (Sweden)

    Milivoj Sironić

    1980-12-01

    Full Text Available Der Autor analysiert die Weibersatire des Semonides und andere seiner kurzen Fragmente. Dabei kommt er zu der Schlussfolgerung, dass sich die Verse der Satire durch eine gute Technik auszeich­ nen, dass aber auch eine unnötige Weitschweifigkeit nicht zu Ubersehen ist. Trotzdem kann man jedoch dem Dichter nicht die künstlerische Überzeugungskraft absprechen, wie auch die Ten­ denz nach Detailschilderungen und die Feinheit geistreicher Charakterisierungen. Die Aussage beinhaltet manchmal eine be­ stimmte innere Ironie in der Einfachheit der Wörter.In kurzen Fragmenten wird die Fähigkeit des Semonides sichtbar, sich sehr präzise auszudrücken. Seine ironisch-epische Sprache ist sehr reich  und verdient vom linguistischen Standpunkt aus Auf­ merksamkeit wegen ihres reichhaltigen lexischen und termino­ logischen Materials, insbesondere was die Bereiche der Tier­ welt und des Essens anbelangt.Die Weltanschauung des Dichters ist in dem ersten Fragment recht deutlich erkennbar. Da sieht man, dass er düster und pessimistisch auf das Leben blickt. Das Fehlen jeglicher positiven Einstellung hat dann den Sar­ kasmus zur Folge, mit dem der Dichter die Darstellung der Weiber einkleidet, ihn aber auch auf die Menschen schlechthin ausweitet.

  14. La physique des infinis

    CERN Document Server

    Bernardeau, Francis; Laplace, Sandrine; Spiro, Michel

    2013-01-01

    Écrire l'histoire de l'Univers, tel est l'objectif commun des physiciens des particules et des astrophysiciens. Pour y parvenir, deux approches s'épaulent : la voie de l'infiniment petit, que l'on emprunte via de gigantesques accélérateurs de particules, et celle de l'infiniment grand, dont le laboratoire est l'Univers. Un Univers qui est bien loin d'avoir livré tous ses secrets. On connaît à peine 4,8 % de la matière qui le constitue, le reste étant composé de matière noire (25,8 %) et d'énergie noire (69,4 %), toutes deux de nature inconnue. Et si la récente découverte du boson de Higgs valide le Modèle standard de la physique des particules, celui-ci est toujours incomplet et doit être étendu à ou dépassé. Est-on arrivé au bout du jeu de poupées russes de la matière ? Quelles sont les particules manquantes ? Faut-il revoir les lois fondamentales ? Quels instruments faut-il mettre en œuvre pour accéder à cette « nouvelle physique » ? Comment parler de Super Big Science aux citoye...

  15. CHAINE DES ROTISSEUR @ HILTON

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    The annual gala dinner of Chaine des Rotisseurs was hosted by Hilton Beijing. The “Ballet Dinner” - a great creation for both art and fine dining lovers was taken place in varies places within the hotel, including hotel lobby, 3rd floor and lobby lounge.

  16. REPRISE DES COURS - Yoga

    CERN Multimedia

    Club de Yoga

    2015-01-01

    REPRISE DES COURS – Venez nombreux ! Yoga, Sophrologie, Tai Chi La liste des cours pour le semestre allant du 1er septembre 2015 au 31 janvier 2016 est disponible sur notre site web : http://club-yoga.web.cern.ch Lieu Les cours ont lieu dans la salle des clubs, à l’entresol du restaurant No 2, Bât. 504 (dans la salle no 3 pour la Sophrologie). Prix des cours Le prix pour le semestre (environ 18 leçons) est fixé à 220 CHF plus 10 CHF d’adhésion annuelle au Club. Couple : 200 CHF par personne. 2 cours par semaine : 400 CHF. Inscriptions Les inscriptions aux cours seront prises directement auprès du professeur, lors de la 1ère séance. Avant de s’inscrire pour le semestre, il est possible d’essayer une séance gratuitement. Informations : http://club-yoga.web.cern.ch ----------------------------------------- cern.ch/club-yoga/

  17. Potenziale des Mobile Commerce

    OpenAIRE

    Turowski, Klaus

    2004-01-01

    Potenziale des Mobile Commerce / B. Bazijanec, K. Turowski. - In: Mobile economy : 4. Workshop Mobile Commerce, 02.-03. Februar 2004, Univ. Augsburg / Key Pousttchi ... (Hrsg.). - Bonn : Ges. für Informatik, 2004. - S. 7-11. - (GI-Edition : Proceedings ; 42)

  18. Vom Ort des Philosophierens

    Directory of Open Access Journals (Sweden)

    Damir Barbaric

    2002-12-01

    Full Text Available Im Aufsatz wird versucht, den ursprünglichen Sinn der Platonischen Bestimmung vom Staunen als Anfang der Philosophie zu ermitteln, und zwar durch eine kritischen Abhebung von ihrer Umdeutung bei Aristoteles, und dann insbesondere in der Stoa wie auch bei Spinoza und Hegel. Dabei wird auf die frühgriechische Erfahrung vom Staunen als _______ aufmerksam gemacht, wo es vor allem die Grundstimmung des Dabeiseins des Göttlichen und der menschlichen Teilnahme am Göttlichen bedeutet. Dem entspricht die bei Platon stark hervorgehobene Rolle des “Pathetischen” am Staunen, das in der nachkommenden Tradition grundsätzlich verlorengegangen ist. Für Platon entspringt das Staunen einem nie zu überwindenden Zustand der wesentlichen philosophischen “Weglosigkeit” (_____, welche schon bei Aristoteles nur noch im Sinne eines unbedingt zu verlassenden Ausgangspunkts der methodisch sicher fortfahrenden philosophischen Wissenschaft verstanden wird. Durch ein Zurückgreifen auf die Diotimas Lehre im Dialog Symposion wird dementgegen die Sokratisch-Platonische “Weglosigkeit” als der einzig angemessene “Ort” des echten Philosophierens bestimmt, welchen es, als das “Zwischen” für das Weltspiel der Unsterblichen und Sterblichen, um jeden Preis zu bewahren und offen zu halten gilt.

  19. Sustainability Decision Support Framework for Industrial System Prioritization

    DEFF Research Database (Denmark)

    Ren, Jingzheng; Wei, Shunan; Goodsite, Michael Evan

    2016-01-01

    A multicriteria decision-making methodology for the sustainability prioritization of industrial systems is proposed. The methodology incorporates a fuzzy Analytic Hierarchy Process method that allows the users to assess the soft criteria using linguistic terms. A fuzzy Analytic Network Process...... method is used to calculate the weights of each criterion, which can tackle the interdependencies and interactions among the criteria. The Preference Ranking Organization Method for Enrichment Evaluation approach is used to prioritize the sustainability sequence of the alternative systems. Moreover......, a sensitivity analysis method was developed to investigate the most critical and sensitive criteria. The developed methodology was illustrated by a case study to rank the sustainability of five alternative hydrogen production technologies. The advantages of the developed methodology over the previous approaches...

  20. Generating and prioritizing optimal paths using ant colony optimization

    Directory of Open Access Journals (Sweden)

    Mukesh Mann

    2015-03-01

    Full Text Available The assurance of software reliability partially depends on testing. Numbers of approaches for software testing are available with their proclaimed advantages and limitations, but accessibility of any one of them is a subject dependent. Time is a critical factor in deciding cost of any project. A deep insight has shown that executing test cases are time consuming and tedious activity. Thus stress has been given to develop algorithms which can suggest better pathways for testing. One such algorithm called Path Prioritization -Ant Colony Optimization (PP-ACO has been suggested in this paper which is inspired by real Ant's foraging behavior to generate optimal paths sequence of a decision to decision (DD path of a graph. The algorithm does full path coverage and suggests the best optimal sequences of path in path testing and prioritizes them according to path strength.

  1. A weight restricted DEA model for FMEA risk prioritization

    Directory of Open Access Journals (Sweden)

    Pauli Adriano de Almada Garcia

    2012-01-01

    Full Text Available In this paper we present a linear programming (LP approach to risk prioritization in failure mode and effects analysis (FMEA. The LP is a data envelopment analysis (DEA-based model considering weight restriction. In a FMEA, we commonly consider three criteria to prioritize the failure modes, occurrence, severity and detectability. These criteria are in an ordinal scale commonly varying from 1 to 10, higher the figure worse the result. Considering the values established for each criteria, in traditional FMEA one adopts a Risk Priority Number, calculated considering the product of criteria, which has been very criticized due to its shortcoming. Through the proposed approach a frontier is established considering the less critical failure modes. Considering this frontier, one can establish how much each failure mode must be improved to become relatively acceptable. A simplified case concerning an AFWS of a two loops PWR power plant is presented to shows the applicability of the proposed approach.

  2. A weight restricted DEA model for FMEA risk prioritization

    Directory of Open Access Journals (Sweden)

    Pauli Adriano de Almada Garcia

    2013-09-01

    Full Text Available In this paper we present a linear programming (LP approach to risk prioritization in failure mode and effects analysis (FMEA. The LP is a data envelopment analysis (DEA-based model considering weight restriction. In a FMEA, we commonly consider three criteria to prioritize the failure modes, occurrence, severity and detectability. These criteria are in an ordinal scale commonly varying from 1 to 10, higher the figure worse the result. Considering the values established for each criteria, in traditional FMEA one adopts a Risk Priority Number, calculated considering the product of criteria, which has been very criticized due to its shortcoming. Through the proposed approach a frontier is established considering the less critical failure modes. Considering this frontier, one can establish how much each failure mode must be improved to become relatively acceptable. A simplified case concerning an AFWS of a two loops PWR power plant is presented to shows the applicability of the proposed approach.

  3. Conceptual thinking for in silico prioritization of candidate disease genes.

    Science.gov (United States)

    Tiffin, Nicki

    2011-01-01

    Prioritization of most likely etiological genes entails predicting and defining a set of characteristics that are most likely to fit the underlying disease gene and scoring candidates according to their fit to this "perfect disease gene" profile. This requires a full understanding of the disease phenotype, characteristics, and any available data on the underlying genetics of the disease. Public databases provide enormous and ever-growing amounts of information that can be relevant to the prioritization of etiological genes. Computational approaches allow this information to be retrieved in an automated and exhaustive way and can therefore facilitate the comprehensive mining of this information, including its combination with sets of empirically generated data, in the process of identifying most likely candidate disease genes.

  4. Modeling and prioritizing demand response programs in power markets

    Energy Technology Data Exchange (ETDEWEB)

    Aalami, H.A.; Moghaddam, M. Parsa; Yousefi, G.R. [Tarbiat Modares University, Tehran (Iran)

    2010-04-15

    One of the responsibilities of power market regulator is setting rules for selecting and prioritizing demand response (DR) programs. There are many different alternatives of DR programs for improving load profile characteristics and achieving customers' satisfaction. Regulator should find the optimal solution which reflects the perspectives of each DR stakeholder. Multi Attribute Decision Making (MADM) is a proper method for handling such optimization problems. In this paper, an extended responsive load economic model is developed. The model is based on price elasticity and customer benefit function. Prioritizing of DR programs can be realized by means of Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) method. Considerations of ISO/utility/customer regarding the weighting of attributes are encountered by entropy method. An Analytical Hierarchy Process (AHP) is used for selecting the most effective DR program. Numerical studies are conducted on the load curve of the Iranian power grid in 2007. (author)

  5. PRIME VALUE METHOD TO PRIORITIZE RISK HANDLING STRATEGIES

    Energy Technology Data Exchange (ETDEWEB)

    Noller, D

    2007-10-31

    Funding for implementing risk handling strategies typically is allocated according to either the risk-averse approach (the worst risk first) or the cost-effective approach (the greatest risk reduction per implementation dollar first). This paper introduces a prime value approach in which risk handling strategies are prioritized according to how nearly they meet the goals of the organization that disburses funds for risk handling. The prime value approach factors in the importance of the project in which the risk has been identified, elements of both risk-averse and cost-effective approaches, and the time period in which the risk could happen. This paper also presents a prioritizer spreadsheet, which employs weighted criteria to calculate a relative rank for the handling strategy of each risk evaluated.

  6. Evaluation des retombees economiques des projets energetiques au Quebec : Analyse couts-avantages de la mini-centrale hydroelectrique de Val-Jalbert

    Science.gov (United States)

    Ossoro, Marcel Thierry

    Evaluer les retombees economiques d'un projet, cela consiste a evaluer le benefice du projet du point de vue de la collectivite. C'est le processus d'analyse, de mesure et d'appreciation de l'impact du projet, sur l'economie locale, regionale ou nationale. Il permet de prendre une decision optimale sur la faisabilite de l'investissement compte tenu de ses incidences sur l'ensemble des agents economiques. L'incoherence des approches et outils dans l'evaluation peut biaiser le calcul de l'impact net du projet, et par consequent, biaiser les termes de la hierarchisation des priorites en matiere d'investissement. Dans le cas des projets sensibles, necessitant de lourds investissements et beaucoup mediatises, comme cela est le cas des projets energetiques ; le biais peut s'averer desastreux et aboutir a une situation chaotique. La presente recherche porte sur l'evaluation des retombees economiques des projets energetiques au Quebec ; la pertinence et la coherence des outils et methodes d'evaluation. Elle est edifiee par une etude de cas. L'etude porte sur l'evaluation du projet de la mini-centrale hydroelectrique de Val Jalbert par la methode de l'analyse couts-avantages. Nous utilisons la methode des prix de reference selon l'approche de l'ONUDI. L'etude revele que le projet de la mini-centrale hydroelectrique de Val Jalbert repond positivement aux deux objectifs : l'efficience---maximisation de la consommation, et l'equite sociale---maximisation de la justice sociale. Il est donc considere, du point de vue de l'ONUDI, comme etant economiquement (ou socialement) rentable. L'analyse couts-avantages est un puissant evaluateur d'impact. Elle evalue le projet en l'integrant dans un cadre coherent d'analyses economiques, qui repose non seulement sur des valeurs nationales mais egalement, qui prend en compte les couts et avantages directs, indirects, internes et externes ; ce qui fait de l'outil, l'evaluateur le plus complet. A travers l'etude, nous montrons comment l

  7. SOAP Opera: Self as Object and Agent in Prioritizing Attention.

    Science.gov (United States)

    Truong, Grace; Todd, Rebecca M

    2016-11-29

    A growing body of evidence has demonstrated that multiple sources of salience tune attentional sets toward aspects of the environment, including affectively and motivationally significant categories of stimuli such as angry faces and reward-associated target locations. Recent evidence further indicates that objects that have gained personal significance through ownership can elicit similar attentional prioritization. Here we discuss current research on sources of attentional prioritization that shape our awareness of the visual world from moment to moment and the underlying neural systems and contextualize what is known about attentional prioritization of our possessions within that research. We review behavioral and neuroimaging research on the influence of self-relevance and ownership on cognition and discuss challenges to this literature stemming from different modes of conceptualizing and operationalizing the self. We argue that ownership taps into both "self-as-object," which characterizes the self as an object with a constellation of traits and attributes, and "self-as-subject," which characterizes the self as an agentic perceiver and knower. Despite an abundance of research probing neural and behavioral indices of self-as-object and its effects on attention, there exists a paucity of research on the influence of self-relevance of attention when self is operationalized from the perspective of a first-person subject. To begin to address this gap, we propose the Self as Ownership in Attentional Prioritization (SOAP) framework to explain how ownership increases salience through attention to external representations of self-identity (i.e., self as object) and attention to contextually mediated permission to act (i.e., self as subject).

  8. Cost-prioritized droop schemes for autonomous microgrids

    DEFF Research Database (Denmark)

    Nutkani, Inam Ullah; Loh, Poh Chiang; Blaabjerg, Frede

    2013-01-01

    centralized optimal dispatch control. To better adapt to this non-uniformity, an alternative viewpoint based on reducing the Total Generation Cost (TGC including fuel cost, emission penalty and other operational concerns) of the microgrid is discussed, from which two new cost-prioritized droop schemes...... are developed. The schemes operate by tuning the dispatch priorities of the DGs and curve shapes of their resulting active power versus frequency plots. Their effective reduction of TGC has been verified through simulation....

  9. Prioritizing the Risk Factors of Severe Early Childhood Caries

    OpenAIRE

    Noha Samir Kabil; Sherif Eltawil

    2017-01-01

    Severe early childhood caries remains the most common chronic disease affecting children. The multifactorial etiology of caries has established a controversy about which risk factors were more significant to its development. Therefore, our study aimed through meticulous statistical analysis to arrange the “well agreed upon” common risk factors in order of significance, to aid the clinician in tailoring an adequate preventive program. The study prioritized or reshuffled the risk factors contri...

  10. Timed Test Case Generation Using Labeled Prioritized Time Petri Nets

    OpenAIRE

    Noureddine Adjir; Pierre De Saqui Sannes; Kamel Rahmouni; Abdelkader Adla

    2012-01-01

    Model-based testing of software and hardware systems uses behavioral and formal models of the systems. The paper presents a technique for model-based black-box conformance testing of real-time systems using Labeled Prioritized Time Petri Nets (LPrTPN). The Timed Input/Output Conformance (tioco) relation, which takes environment assumptions into account, serves as reference to decide of implementation correctness. Test suites are derived automatically from a LPrTPN made up of two concurrent su...

  11. Solving Orienteering with Category Constraints Using Prioritized Search

    OpenAIRE

    Bolzoni, Paolo; Helmer, Sven

    2017-01-01

    We develop an approach for solving rooted orienteering problems with category constraints as found in tourist trip planning and logistics. It is based on expanding partial solutions in a systematic way, prioritizing promising ones, which reduces the search space we have to traverse during the search. The category constraints help in reducing the space we have to explore even further. We implement an algorithm that computes the optimal solution and also illustrate how our approach can be turne...

  12. Proposal and Analysis of a Novel Prioritized OCBS Scheme

    Institute of Scientific and Technical Information of China (English)

    WANG Jian; ZHANG Min; YE Pei-da; LI Qing

    2004-01-01

    In this paper, a novel prioritized Optical Burst Switching (OCBS) scheme for the next-generation optical Internet is proposed and investigated systematically through theoretical analysis and network simulation. Analysis shows that the proposed scheme is able to achieve modestly fine traffic differentiation in a simple and easy way. The simulation results agree with the theoretical analysis and they are useful in traffic engineering of optical burst switching networks.

  13. Injectabilite des coulis de ciment dans des milieux fissures

    Science.gov (United States)

    Mnif, Thameur

    Le travail presente ici est un bilan du travaux de recherche effectues sur l'injectabilite des coulis de ciment dans lu milieux fissures. Un certain nombre de coulis a base de ciment Portland et microfin ont ete selectionnes afin de caracteriser leur capacite a penetrer des milieux fissures. Une partie des essais a ete menee en laboratoire. L'etude rheologique des differents melanges a permis de tester l'influence de l'ajout de superplastifiant et/ou de fumee de silice sur la distribution granulometrique des coulis et par consequent sur leur capacite a injecter des colonnes de sable simulant un milieu fissure donne. La classe granulometrique d'un coulis, sa stabilite et sa fluidite sont apparus comme les trois facteurs principaux pour la reussite d'une injection. Un facteur de finesse a ete defini au cours de cette etude: base sur la classe granulometrique du ciment et sa stabilite, il peut entrer dans la formulation theorique du debit d'injection avant application sur chantier. La deuxieme et derniere partie de l'etude presente les resultats de deux projets de recherche sur l'injection realises sur chantier. L'injection de dalles de beton fissurees a permis le suivi de l'evolution des pressions avec la distance au point d'injection. L'injection de murs de maconnerie a caractere historique a montre l'importance de la definition de criteres de performance des coulis a utiliser pour traiter un milieu donne et pour un objectif donne. Plusieurs melanges peuvent ainsi etre predefinis et mis a disposition sur le chantier. La complementarite des ciments traditionnels et des ciments microfins devient alors un atout important. Le choix d'utilisation de ces melanges est fonction du terrain rencontre. En conclusion, cette recherche etablit une methodologie pour la selection des coulis a base de ciment et des pressions d'injection en fonction de l'ouverture des fissures ou joints de construction.

  14. Guidelines for risk-based prioritization of DOE activities

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-04-01

    This standard describes issues that should be considered when comparing, selecting, or implementing risk-based prioritization (RBP) systems. It also discusses characteristics that should be used in evaluating the quality of an RBP system and its associated results. The purpose of this standard is to provide guidance for selecting or developing an RBP system so that when implemented, it will: (a) improve the quality of the RBP systems employed by DOE and its contractors; (b) improve the consistency and comparability of RBP system results; (c) satisfy DOE requests to perform RBP; (d) help ensure that limited resources are used efficiently and effectively; (e) help ensure that characteristics for evaluating RBP systems are met and properly balanced; (f) promote greater understanding, use, and acceptance of RBP systems; (g) promote greater understanding between DOE and its stakeholders and regulators; (h) improve the quality of resource allocation, planning, and scheduling decisions. This standard is applicable to any and all uses of RBP by DOE elements, including cases in which RBP is requested by DOE or is used to help allocate resources among alternatives that compete for resources. Prioritizing alternatives that compete for limited resources encompasses many policy issues that are inherent to an RBP effort. It is the position of this standard that policy issues should be determined by the decision maker(s) requesting the prioritization. For additional information on policy issues, refer to section 10 on Application Guidance for Policy Issues.

  15. Research Trends in Wireless Visual Sensor Networks When Exploiting Prioritization

    Directory of Open Access Journals (Sweden)

    Daniel G. Costa

    2015-01-01

    Full Text Available The development of wireless sensor networks for control and monitoring functions has created a vibrant investigation scenario, where many critical topics, such as communication efficiency and energy consumption, have been investigated in the past few years. However, when sensors are endowed with low-power cameras for visual monitoring, a new scope of challenges is raised, demanding new research efforts. In this context, the resource-constrained nature of sensor nodes has demanded the use of prioritization approaches as a practical mechanism to lower the transmission burden of visual data over wireless sensor networks. Many works in recent years have considered local-level prioritization parameters to enhance the overall performance of those networks, but global-level policies can potentially achieve better results in terms of visual monitoring efficiency. In this paper, we make a broad review of some recent works on priority-based optimizations in wireless visual sensor networks. Moreover, we envisage some research trends when exploiting prioritization, potentially fostering the development of promising optimizations for wireless sensor networks composed of visual sensors.

  16. Prioritizing lean management practices in public and private hospitals.

    Science.gov (United States)

    Hussain, Matloub; Malik, Mohsin

    2016-05-16

    Purpose - The purpose of this paper is to prioritize 21 healthcare wastes in public and private hospitals of United Arab Emirates (UAE). Design/methodology/approach - Seven healthcare wastes linked with lean management are further decomposed in to sub-criteria and to deal with this complexity of multi criteria decision-making process, analytical hierarchical process (AHP) method is used in this research. Findings - AHP framework for this study resulted in a ranking of 21 healthcare wastes in public and private hospitals of UAE. It has been found that management in private healthcare systems of UAE is putting more emphasis on the inventory waste. On the other hand, over processing waste has got highest weight in public hospitals of UAE. Research limitations/implications - The future directions of this research would be to apply a lean set of tools for the value stream optimization of the prioritized key improvement areas. Practical implications - This is a contribution to the continuing research into lean management, giving practitioners and designers a practical way for measuring and implementing lean practices across health organizations. Originality/value - The contribution of this research, through successive stages of data collection, measurement analysis and refinement, is a set of reliable and valid framework that can be subsequently used in conceptualization, prioritization of the waste reduction strategies in healthcare management.

  17. Research trends in wireless visual sensor networks when exploiting prioritization.

    Science.gov (United States)

    Costa, Daniel G; Guedes, Luiz Affonso; Vasques, Francisco; Portugal, Paulo

    2015-01-15

    The development of wireless sensor networks for control and monitoring functions has created a vibrant investigation scenario, where many critical topics, such as communication efficiency and energy consumption, have been investigated in the past few years. However, when sensors are endowed with low-power cameras for visual monitoring, a new scope of challenges is raised, demanding new research efforts. In this context, the resource-constrained nature of sensor nodes has demanded the use of prioritization approaches as a practical mechanism to lower the transmission burden of visual data over wireless sensor networks. Many works in recent years have considered local-level prioritization parameters to enhance the overall performance of those networks, but global-level policies can potentially achieve better results in terms of visual monitoring efficiency. In this paper, we make a broad review of some recent works on priority-based optimizations in wireless visual sensor networks. Moreover, we envisage some research trends when exploiting prioritization, potentially fostering the development of promising optimizations for wireless sensor networks composed of visual sensors.

  18. Peste des Petits Ruminants Virus in Tibet, China

    Science.gov (United States)

    Bao, Jingyue; Wu, Xiaodong; Liu, Yutian; Li, Lin; Liu, Chunju; Suo, Longciren; Xie, Zhonglun; Zhao, Wenji; Zhang, Wei; Yang, Nan; Li, Jinming

    2009-01-01

    Serologic and molecular evidence indicates that peste des petits ruminants virus (PPRV) infection has emerged in goats and sheep in the Ngari region of southwestern Tibet, People’s Republic of China. Phylogenetic analysis confirms that the PPRV strain from Tibet is classified as lineage 4 and is closely related to viruses currently circulating in neighboring countries of southern Asia. PMID:19193278

  19. Dopage et protection des jeunes sportifs : Loin des affaires

    OpenAIRE

    Guy, Daniel

    2002-01-01

    National audience; Loin des affaires et des révélations polémiques de la presse, les jeunes plébiscitent massivement les activités sportives. Sport compétition, sport participation, sport détente... Pourtant, quand la pratique devient intense, que les entraînements et les compétitions s'enchaînent à un rythme soutenu, l'ombre des conduites dopantes vient déchirer la quiétude des uns et des autres. Or, que savons-nous réellement de la pratique des jeunes sportifs ? Comment préparent-ils les co...

  20. Le corps des anges

    OpenAIRE

    Margel,Serge

    2017-01-01

    Ce séminaire fait suite à un cycle de conférences données en 2014 sur la notion de corps de chair dans le premier christianisme. Cette année la recherche a porté sur le corps spécifique des anges dans la patristique grecque et latine. Sur la base d’un corpus de textes délimité, j’ai essayé de montrer deux choses principales : d’un côté, on ne peut pas comprendre la spécificité du corps des anges sans l’inscrire dans le champ de l’angélologie chrétienne, qui assimile l’ange et l’âme, et d’un a...

  1. Typologie des Accidents Cyclistes

    OpenAIRE

    Amoros, Emmanuelle; BILLOT-GRASSET, Alice; Hours, Martine

    2015-01-01

    L'usage du vélo est en hausse en ville ; cette pratique est encouragée dans le cadre du développement durable et de la lutte contre la sédentarité. Pour accompagner cela, il faut réduire les risques d'accident, et pour ce faire, mieux les connaître. Nous utilisons le Registre des victimes de la circulation routière du Rhône, basé sur les services hospitaliers (dont les urgences) ; il est quasi-exhaustif : env. 1100 blessés à vélo/an versus 120 dans les données officielles. L'ensemble des cycl...

  2. Table des tableaux

    OpenAIRE

    2014-01-01

    Présentation schématique de la production et de la transformation de l’acier 16 Chronologie des nationalisations en France 33 Importations de coke de la France 48 Comparaison entre les prix de l’acier en Allemagne et en France, août 1949 99 Prix du marché intérieur et du marché mondial pour les laminés marchands (qualité Thomas) 101 Évolution de la production allemande et française d’acier brut 119 Comparaison des coûts de l’extraction de charbon en Allemagne et en France, 1949 138 Évolution ...

  3. Table des illustrations

    OpenAIRE

    2017-01-01

    Illustration de couverture : Dolmen n° 2 des Géandes avec le Mont Ventoux en arrière-plan, octobre 2006 (cliché Wolfgang Pape). Illustration de la quatrième de couverture : René Gilles sur le dolmen n° 5 des Géandes en mars 1989 (cliché Wolfgang Pape). Fig. 1 - Gorges de l’Ardèche au niveau de la grotte de Saint-Marcel (cliché Bernard Gély) 21 Fig. 2 - Doline de Bidon (cliché Wolfgang Pape) 21 Fig. 3 - Paysage de garrigue (cliché Wolfgang Pape) 22 Fig. 4 - Données radio-chronométriques de l’A...

  4. Direction des Publications

    African Journals Online (AJOL)

    Synthese

    accroissement des pressions sur les écosystèmes et les espèces qu‟ils renferment. La pollution de ... Exacerbée par le changement climatique, cette anthropisation .... majeure partie de son aire de répartition. .... de cette région. .... savoir les impacts à plus grande échelle et ..... habitats et la totalité de l'aire géographique.

  5. Le vernis des apparences

    Directory of Open Access Journals (Sweden)

    Grazia Nicosia

    2010-04-01

    Full Text Available Le but de cet article est de comprendre l’incidence sémiotique du nettoyage d’un tableau ainsi que la résultante cognitive induite sur l’observateur. Cette étude confronte l’analyse des phénomènes visuels engendrés par le jaunissement du vernis et son retrait, à des entretiens réalisés à dessein. Le retrait d’un vernis jauni change considérablement l’image. L’heure, le climat, la saison et l’activité même des personnages s’en trouvent ainsi modifié. La patine peut être perçue, soit comme un obstacle à l’exploration, soit pour ceux qui l’apprécient, comme le medium d’une relation plus intime entre l’œuvre et l’observateur.The purpose of this article is to understand the semiotic impact of the cleaning of a painting and the cognitive effects induced on the observer. This study analyses conjointly the visual phenomenon generated by yellowing varnish and its removal and controlled interviews of observers.The removal of yellowing varnish modifies considerably the perception of the picture. Daytime, climate, season and characters activities are modified. The patina may be perceived either as an obstacle to the painting exploration, or, for those who appreciate it, as a medium for a closer relationship between the painting and the observer.

  6. Dictionnaire des risques psychosociaux

    CERN Document Server

    Zawieja, Philippe

    2014-01-01

    Stress, suicide, harcèlement, épuisement professionnel, workaholism... Au-delà de la souffrance qu'elles désignent, ces notions souvent récentes constituent une approche inédite, et demandent à mieux être comprises, dans leur ensemble et isolément. C'est tout l'enjeu de ce dictionnaire, pionnier en son genre. Le lecteur y trouvera représentés, avec les 314 entrées (rédigées par 251 contributeurs) qui le composent, tous les champs disciplinaires s'intéressant à la souffrance au travail : psychologie du travail et des organisations, psychologie sociale et psychosociologie, psychanalyse, psychopathologie et psychiatrie, ergonomie, sociologie du travail et des organisations, médecine du travail, droit du travail et de la sécurité sociale, sciences de gestion, philosophie... Y sont détaillés les principaux concepts, notions, approches, méthodes, théories, outils, études, etc., ayant cours dans l'étude des risques psychosociaux, mais aussi certaines professions emblématiques (infirmières,...

  7. Grundlagen des Tissue Engineering

    Science.gov (United States)

    Mayer, Jörg; Blum, Janaki; Wintermantel, Erich

    Die Organtransplantation stellt eine verbreitete Therapie dar, um bei krankheitsoder unfallbedingter Schädigung eines Organs die Gesamtheit seiner Funktionen wieder herzustellen, indem es durch ein Spenderorgan ersetzt wird. Organtransplantationen werden für die Leber, die Niere, die Lunge, das Herz oder bei schweren grossflächigen Verbrennungen der Haut vorgenommen. Der grosse apparative, personelle und logistische Aufwand und die Risiken der Transplantationschirurgie (Abstossungsreaktionen) sowie die mangelnde Verfügbarkeit von immunologisch kompatiblen Spenderorganen führen jedoch dazu, dass der Bedarf an Organtransplantaten nur zu einem sehr geringen Teil gedeckt werden kann. Sind Spenderorgane nicht verfügbar, können in einzelnen Fällen lebenswichtige Teilfunktionen, wie beispielsweise die Filtrationsfunktion der Niere durch die Blutreinigung mittels Dialyse ersetzt oder, bei mangelnder Funktion der Bauchspeicheldrüse (Diabetes), durch die Verabreichung von Insulin ein normaler Zustand des Gesamtorganismus auch über Jahre hinweg erhalten werden. Bei der notwendigen lebenslangen Anwendung apparativer oder medikamentöser Therapie können für den Patienten jedoch häufig schwerwiegende, möglicherweise lebensverkürzende Nebenwirkungen entstehen. Daher werden in der Forschung Alternativen gesucht, um die Funktionen des ausgefallenen Organs durch die Implantation von Zellen oder in vitro gezüchteten Geweben möglichst umfassend wieder herzustellen. Dies erfordert biologisch aktive Implantate, welche die für den Stoffwechsel des Organs wichtigen Zellen enthalten und einen organtypischen Stoffwechsel entfalten.

  8. Effect of risk aversion on prioritizing conservation projects.

    Science.gov (United States)

    Tulloch, Ayesha I T; Maloney, Richard F; Joseph, Liana N; Bennett, Joseph R; Di Fonzo, Martina M I; Probert, William J M; O'Connor, Shaun M; Densem, Jodie P; Possingham, Hugh P

    2015-04-01

    Conservation outcomes are uncertain. Agencies making decisions about what threat mitigation actions to take to save which species frequently face the dilemma of whether to invest in actions with high probability of success and guaranteed benefits or to choose projects with a greater risk of failure that might provide higher benefits if they succeed. The answer to this dilemma lies in the decision maker's aversion to risk--their unwillingness to accept uncertain outcomes. Little guidance exists on how risk preferences affect conservation investment priorities. Using a prioritization approach based on cost effectiveness, we compared 2 approaches: a conservative probability threshold approach that excludes investment in projects with a risk of management failure greater than a fixed level, and a variance-discounting heuristic used in economics that explicitly accounts for risk tolerance and the probabilities of management success and failure. We applied both approaches to prioritizing projects for 700 of New Zealand's threatened species across 8303 management actions. Both decision makers' risk tolerance and our choice of approach to dealing with risk preferences drove the prioritization solution (i.e., the species selected for management). Use of a probability threshold minimized uncertainty, but more expensive projects were selected than with variance discounting, which maximized expected benefits by selecting the management of species with higher extinction risk and higher conservation value. Explicitly incorporating risk preferences within the decision making process reduced the number of species expected to be safe from extinction because lower risk tolerance resulted in more species being excluded from management, but the approach allowed decision makers to choose a level of acceptable risk that fit with their ability to accommodate failure. We argue for transparency in risk tolerance and recommend that decision makers accept risk in an adaptive management

  9. Prioritizing land and sea conservation investments to protect coral reefs.

    Directory of Open Access Journals (Sweden)

    Carissa J Klein

    Full Text Available BACKGROUND: Coral reefs have exceptional biodiversity, support the livelihoods of millions of people, and are threatened by multiple human activities on land (e.g. farming and in the sea (e.g. overfishing. Most conservation efforts occur at local scales and, when effective, can increase the resilience of coral reefs to global threats such as climate change (e.g. warming water and ocean acidification. Limited resources for conservation require that we efficiently prioritize where and how to best sustain coral reef ecosystems. METHODOLOGY/PRINCIPAL FINDINGS: Here we develop the first prioritization approach that can guide regional-scale conservation investments in land- and sea-based conservation actions that cost-effectively mitigate threats to coral reefs, and apply it to the Coral Triangle, an area of significant global attention and funding. Using information on threats to marine ecosystems, effectiveness of management actions at abating threats, and the management and opportunity costs of actions, we calculate the rate of return on investment in two conservation actions in sixteen ecoregions. We discover that marine conservation almost always trumps terrestrial conservation within any ecoregion, but terrestrial conservation in one ecoregion can be a better investment than marine conservation in another. We show how these results could be used to allocate a limited budget for conservation and compare them to priorities based on individual criteria. CONCLUSIONS/SIGNIFICANCE: Previous prioritization approaches do not consider both land and sea-based threats or the socioeconomic costs of conserving coral reefs. A simple and transparent approach like ours is essential to support effective coral reef conservation decisions in a large and diverse region like the Coral Triangle, but can be applied at any scale and to other marine ecosystems.

  10. Enabling task-based information prioritization via semantic web encodings

    Science.gov (United States)

    Michaelis, James R.

    2016-05-01

    Modern Soldiers rely upon accurate and actionable information technology to achieve mission objectives. While increasingly rich sensor networks for Areas of Operation (AO) can offer many directions for aiding Soldiers, limitations are imposed by current tactical edge systems on the rate that content can be transmitted. Furthermore, mission tasks will often require very specific sets of information which may easily be drowned out by other content sources. Prior research on Quality and Value of Information (QoI/VoI) has aimed to define ways to prioritize information objects based on their intrinsic attributes (QoI) and perceived value to a consumer (VoI). As part of this effort, established ranking approaches for obtaining Subject Matter Expert (SME) recommendations, such as the Analytic Hierarchy Process (AHP) have been considered. However, limited work has been done to tie Soldier context - such as descriptions of their mission and tasks - back to intrinsic attributes of information objects. As a first step toward addressing the above challenges, this work introduces an ontology-backed approach - rooted in Semantic Web publication practices - for expressing both AHP decision hierarchies and corresponding SME feedback. Following a short discussion on related QoI/VoI research, an ontology-based data structure is introduced for supporting evaluation of Information Objects, using AHP rankings designed to facilitate information object prioritization. Consistent with alternate AHP approaches, prioritization in this approach is based on pairwise comparisons between Information Objects with respect to established criteria, as well as on pairwise comparison of the criteria to assess their relative importance. The paper concludes with a discussion of both ongoing and future work.

  11. Prioritizing land and sea conservation investments to protect coral reefs.

    Science.gov (United States)

    Klein, Carissa J; Ban, Natalie C; Halpern, Benjamin S; Beger, Maria; Game, Edward T; Grantham, Hedley S; Green, Alison; Klein, Travis J; Kininmonth, Stuart; Treml, Eric; Wilson, Kerrie; Possingham, Hugh P

    2010-08-30

    Coral reefs have exceptional biodiversity, support the livelihoods of millions of people, and are threatened by multiple human activities on land (e.g. farming) and in the sea (e.g. overfishing). Most conservation efforts occur at local scales and, when effective, can increase the resilience of coral reefs to global threats such as climate change (e.g. warming water and ocean acidification). Limited resources for conservation require that we efficiently prioritize where and how to best sustain coral reef ecosystems. Here we develop the first prioritization approach that can guide regional-scale conservation investments in land- and sea-based conservation actions that cost-effectively mitigate threats to coral reefs, and apply it to the Coral Triangle, an area of significant global attention and funding. Using information on threats to marine ecosystems, effectiveness of management actions at abating threats, and the management and opportunity costs of actions, we calculate the rate of return on investment in two conservation actions in sixteen ecoregions. We discover that marine conservation almost always trumps terrestrial conservation within any ecoregion, but terrestrial conservation in one ecoregion can be a better investment than marine conservation in another. We show how these results could be used to allocate a limited budget for conservation and compare them to priorities based on individual criteria. Previous prioritization approaches do not consider both land and sea-based threats or the socioeconomic costs of conserving coral reefs. A simple and transparent approach like ours is essential to support effective coral reef conservation decisions in a large and diverse region like the Coral Triangle, but can be applied at any scale and to other marine ecosystems.

  12. PBT assessment and prioritization of contaminants of emerging concern: Pharmaceuticals.

    Science.gov (United States)

    Sangion, Alessandro; Gramatica, Paola

    2016-05-01

    The strong and widespread use of pharmaceuticals, together with incorrect disposal procedures, has recently made these products contaminants of emerging concern (CEC). Unfortunately, little is known about pharmaceuticals' environmental behaviour and ecotoxicity, so that EMEA (European Medicines Agency) released guidelines for the pharmaceuticals' environmental risk assessment. In particular, there is a severe lack of information about persistence, bioaccumulation and toxicity (PBT) of the majority of the thousands of substances on the market. Computational tools, like QSAR (Quantitative Structure Activity Relationship) models, are the only way to screen large sets of chemicals in short time, with the aim of ranking, highlighting and prioritizing the most environmentally hazardous for focusing further experimental studies. In this work we propose a screening method to assess the potential persistence, bioaccumulation and toxicity of more than 1200 pharmaceutical ingredients, based on the application of two different QSAR models. We applied the Insubria-PBT Index, a MLR (Multiple Linear Regression) QSAR model based on four simple molecular descriptors, implemented in QSARINS software, and able to synthesize the PBT potential in a unique cumulative value and the US-EPA PBT Profiler that assesses the PBT behaviour evaluating separately P, B and T. Particular attention was given to the study of Applicability Domain in order to provide reliable predictions. An agreement of 86% was found between the two models and a priority list of 35 pharmaceuticals, highlighted as potential PBTs by consensus, was proposed for further experimental validation. Moreover, the results of this computational screening are in agreement with preliminary experimental data in the literature. This study shows how in silico models can be applied in the hazard assessment to perform preliminary screening and prioritization of chemicals, and how the identification of the structural features, mainly

  13. Prioritization strategies in clinical practice guidelines development: a pilot study

    Directory of Open Access Journals (Sweden)

    Torres Marcela

    2010-03-01

    Full Text Available Abstract Objective Few methodological studies address the prioritization of clinical topics for the development of Clinical Practice Guidelines (CPGs. The aim of this study was to validate a methodology for Priority Determination of Topics (PDT of CPGs. Methods and results Firstly, we developed an instrument for PDT with 41 criteria that were grouped under 10 domains, based on a comprehensive systematic search. Secondly, we performed a survey of stakeholders involved in CPGs development, and end users of guidelines, using the instrument. Thirdly, a pilot testing of the PDT procedure was performed in order to choose 10 guideline topics among 34 proposed projects; using a multi-criteria analysis approach, we validated a mechanism that followed five stages: determination of the composition of groups, item/domain scoring, weights determination, quality of the information used to support judgments, and finally, topic selection. Participants first scored the importance of each domain, after which four different weighting procedures were calculated (including the survey results. The process of weighting was determined by correlating the data between them. We also reported the quality of evidence used for PDT. Finally, we provided a qualitative analysis of the process. The main domains used to support judgement, having higher quality scores and weightings, were feasibility, disease burden, implementation and information needs. Other important domains such as user preferences, adverse events, potential for health promotion, social effects, and economic impact had lower relevance for clinicians. Criteria for prioritization were mainly judged through professional experience, while good quality information was only used in 15% of cases. Conclusion The main advantages of the proposed methodology are supported by the use of a systematic approach to identify, score and weight guideline topics selection, limiting or exposing the influence of personal biases

  14. Etude des phenomenes dynamiques ultrarapides et des caracteristiques impulsionnelles d'emission terahertz du supraconducteur YBCO

    Science.gov (United States)

    Savard, Stephane

    Les premieres etudes d'antennes a base de supraconducteurs a haute temperature critique emettant une impulsion electromagnetique dont le contenu en frequence se situe dans le domaine terahertz remontent a 1996. Une antenne supraconductrice est formee d'un micro-pont d'une couche mince supraconductrice sur lequel un courant continu est applique. Un faisceau laser dans le visible est focalise sur le micro-pont et place le supraconducteur dans un etat hors-equilibre ou des paires sont brisees. Grace a la relaxation des quasiparticules en surplus et eventuellement de la reformation des paires supraconductrices, nous pouvons etudier la nature de la supraconductivite. L'analyse de la cinetique temporelle du champ electromagnetique emis par une telle antenne terahertz supraconductrice s'est averee utile pour decrire qualitativement les caracteristiques de celle-ci en fonction des parametres d'operation tels que le courant applique, la temperature et la puissance d'excitation. La comprehension de l'etat hors-equilibre est la cle pour comprendre le fonctionnement des antennes terahertz supraconductrices a haute temperature critique. Dans le but de comprendre ultimement cet etat hors-equilibre, nous avions besoin d'une methode et d'un modele pour extraire de facon plus systematique les proprietes intrinseques du materiau qui compose l'antenne terahertz a partir des caracteristiques d'emission de celle-ci. Nous avons developpe une procedure pour calibrer le spectrometre dans le domaine temporel en utilisant des antennes terahertz de GaAs bombarde aux protons H+ comme emetteur et detecteur. Une fois le montage calibre, nous y avons insere une antenne emettrice dipolaire de YBa 2Cu3O7-delta . Un modele avec des fonctions exponentielles de montee et de descente du signal est utilise pour lisser le spectre du champ electromagnetique de l'antenne de YBa 2Cu3O7-delta, ce qui nous permet d'extraire les proprietes intrinseques de ce dernier. Pour confirmer la validite du modele

  15. Interaction Matrices as a Tool for Prioritizing Radioecology Research

    Energy Technology Data Exchange (ETDEWEB)

    Mora, J.C.; Robles, Beatriz [Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas - CIEMAT (Spain); Bradshaw, Clare; Stark, Karolina [Stockholm University (Sweden); Sweeck, Liev; Vives i Batlle, Jordi [Belgian Nuclear Research Centre SCK-CEN (Belgium); Beresford, Nick [Centre for Ecology and Hydrology - CEH (United Kingdom); Thoerring, Havard; Dowdall, Mark [Norwegian Radiation Protection Authority - NRPA (Norway); Outola, Iisa; Turtiainen, Tuukka; Vetikko, Virve [STUK - Radiation and Nuclear Safety Authority (Finland); Steiner, Martin [Federal Office for Radiation Protection - BfS (Germany); Beaugelin-Seiller, Karine; Fevrier, Laureline; Hurtevent, Pierre; Boyer, Patrick [Institut de Radioprotection et de Surete Nucleaire - IRSN (France)

    2014-07-01

    Interaction Matrices as a Tool for Prioritizing Radioecology Research J.C. Mora CIEMAT In 2010 the Strategy for Allied Radioecology (STAR) was launched with several objectives aimed towards integrating the radioecology research efforts of nine institutions in Europe. One of these objectives was the creation of European Radioecology Observatories. The Chernobyl Exclusion Zone (CEZ) and the Upper Silesian Coal Basin (USCB), a coal mining area in Poland, have been chosen after a selection process. A second objective was to develop a system for improving and validating the capabilities of predicting the behaviour of the main radionuclides existing at these observatories. Interaction Matrices (IM) have been used since the 1990's as a tool for developing ecological conceptual models and have also been used within radioecology. The Interaction Matrix system relies on expert judgement for structuring knowledge of a given ecosystem at the conceptual level and was selected for use in the STAR project. A group of experts, selected from each institution of STAR, designed two matrices with the main compartments for each ecosystem (a forest in CEZ and a lake in USCB). All the features, events and processes (FEPs) which could affect the behaviour of the considered radionuclides, focusing on radiocaesium in the Chernobyl forest and radium in the Rontok-Wielki lake, were also included in each IM. Two new sets of experts were appointed to review, improve and prioritize the processes included in each IM. A first processing of the various candidate interaction matrices produced a single interaction matrix for each ecosystem which incorporated all experts combined knowledge. During the prioritization of processes in the IMs, directed towards developing a whole predictive model of radionuclides behaviour in those ecosystems, raised interesting issues related to the processes and parameters involved, regarding the existing knowledge in them. This exercise revealed several processes

  16. Sensitivity-based research prioritization through stochastic characterization modeling

    DEFF Research Database (Denmark)

    Wender, Ben A.; Prado-Lopez, Valentina; Fantke, Peter

    2017-01-01

    Product developers using life cycle toxicity characterization models to understand the potential impacts of chemical emissions face serious challenges related to large data demands and high input data uncertainty. This motivates greater focus on model sensitivity toward input parameter variability...... to guide research efforts in data refinement and design of experiments for existing and emerging chemicals alike. This study presents a sensitivity-based approach for estimating toxicity characterization factors given high input data uncertainty and using the results to prioritize data collection according...

  17. Effects of preference heterogeneity among landowners on spatial conservation prioritization

    DEFF Research Database (Denmark)

    Nielsen, Anne Sofie Elberg; Strange, Niels; Bruun, Hans Henrik

    2017-01-01

    The participation of private landowners in conservation is crucial to efficient biodiversity conservation. This is especially the case in settings where the share of private ownership is large and the economic costs associated with land acquisition are high. We used probit regression analysis...... into a spatial prioritization for conservation of unmanaged forests. The choice models are based on sociodemographic data on the entire population of Danish forest owners and historical data on their participation in conservation schemes. Inclusion in the model of information on private landowners' willingness...

  18. Prioritizing substitution of organic solvents in industrial cleaning processes

    DEFF Research Database (Denmark)

    Rasmussen, Pia Brunn; Jacobsen, Thomas

    1997-01-01

    A method for prioritizing the substitution of volatile organic compounds (VOC) used in industrial cleaning processes is developed. The result is a matrix, which, if all information can be obtained, gives a comprehensive description of the effects, exposure and emission of VOC, as well...... as the prospects for performing the substitution with a vegetable ester. It can be a tool for companies to decide which cleaning process has the highest demand for substitution, if there is a choice between several processes, but it may also be a tool to convince companies to use non-volatile, low-toxic cleaning...

  19. Gene prioritization for livestock diseases by data integration

    DEFF Research Database (Denmark)

    Jiang, Li; Sørensen, Peter; Thomsen, Bo Stjerne

    2012-01-01

    with quantitative traits and diseases in livestock species. The approach uses ortholog mapping and integrates information on disease or trait phenotypes, gene-associated phenotypes, and protein-protein interactions. It was used for ranking all known genes present in the cattle genome for their potential roles...... candidate genes in any livestock species........ Our study provides a general framework for prioritizing genes associated with various complex traits in different species. To our knowledge this is the first time that gene expression, ortholog mapping, protein interactions, and biomedical text data have been integrated systematically for ranking...

  20. Robust and accurate multi-view reconstruction by prioritized matching

    DEFF Research Database (Denmark)

    Ylimaki, Markus; Kannala, Juho; Holappa, Jukka;

    2012-01-01

    a prioritized matching method which expands the most promising seeds first. The output of the method is a three-dimensional point cloud. Unlike previous correspondence growing approaches our method allows to use the best-first matching principle in the generic multi-view stereo setting with arbitrary number...... of input images. Our experiments show that matching the most promising seeds first provides very robust point cloud reconstructions efficiently with just a single expansion step. A comparison to the current state-of-the-art shows that our method produces reconstructions of similar quality but significantly...

  1. PRIORITIZED QUEUE WITH ROUND ROBIN SCHEDULER FOR BUFFERED CROSSBAR SWITCHES

    Directory of Open Access Journals (Sweden)

    N. Narayanan Prasanth

    2014-03-01

    Full Text Available Research in high speed switching systems is in greater demand as the internet traffic gets rapid increase. Designing an efficient scheduling algorithm with high throughput and low delay is an open challenge. Most of the algorithms achieve 100% throughput in uniform traffics but failed to attain the same performance under non-uniform traffics. Moreover these algorithms are also suffers from starvation leads to extended waiting time of VOQ. In this paper, Prioritized Queue with Round Robin Scheduler (PQRS is proposed for Buffered Crossbar Switches. We proved that our proposed scheduler can achieve 85% throughput under any non-uniform traffic without starvation.

  2. Code Coverage Based Test Case Selection and Prioritization

    Directory of Open Access Journals (Sweden)

    R.Beena

    2013-11-01

    Full Text Available Regression Testing is exclusively executed to guarantee the desirable functionality of existing softwareafter pursuing quite a few amendments or variations in it. Perhaps, it testifies the quality of the modifiedsoftware by concealing the regressions orsoftware bugs in both functional and non-functional applicationsof the system. In fact, the maintenance of test suite is enormous as it necessitates a big investment of timeand money on test cases on a large scale. So, minimizing the test suite becomesthe indispensable requisiteto lessen the budget on regression testing. Precisely, this research paper aspires to present an innovativeapproach for the effectiveselection and prioritization of test cases which in return may procure a maximumcode average.

  3. Prioritizing Residential Land Value Determinants in Onitsha, Nigeria

    Directory of Open Access Journals (Sweden)

    Fidelis Ifeanyi Emoh

    2013-03-01

    Full Text Available This study was undertaken to analyze the various determinants of residential land values and the strength of the different factors contributing to land value variations in Onitsha, Nigeria. The factor analysis and the principal component techniques were applied in the analysis of spatial variations and the relationship between 31 identifiable factors influencing residential land values in Onitsha, Anambra State of Nigeria. By using regression analysis, the 13 main factors shaping land values in Onitsha were established, prioritized and ranked as accessibility, neighborhood quality, land title, zoning regulations, transportation, rent, improvement tax, environmental quality, view of amenities, travel time to the city centre and irrevocable power of attorney.

  4. Reticulation des fibres lignocellulosiques

    Science.gov (United States)

    Landrevy, Christel

    Pour faire face à la crise économique la conception de papier à valeur ajoutée est développée par les industries papetières. Le but de se projet est l'amélioration des techniques actuelles de réticulation des fibres lignocellulosiques de la pâte à papier visant à produire un papier plus résistant. En effet, lors des réactions de réticulation traditionnelles, de nombreuses liaisons intra-fibres se forment ce qui affecte négativement l'amélioration anticipée des propriétés physiques du papier ou du matériau produit. Pour éviter la formation de ces liaisons intra-fibres, un greffage sur les fibres de groupements ne pouvant pas réagir entre eux est nécessaire. La réticulation des fibres par une réaction de « click chemistry » appelée cycloaddition de Huisgen entre un azide et un alcyne vrai, catalysée par du cuivre (CuAAC) a été l'une des solutions trouvée pour remédier à ce problème. De plus, une adaptation de cette réaction en milieux aqueux pourrait favoriser son utilisation en milieu industriel. L'étude que nous désirons entreprendre lors de ce projet vise à optimiser la réaction de CuAAC et les réactions intermédiaires (propargylation, tosylation et azidation) sur la pâte kraft, en milieu aqueux. Pour cela, les réactions ont été adaptées en milieu aqueux sur la cellulose microcristalline afin de vérifier sa faisabilité, puis transférée à la pâte kraft et l'influence de différents paramètres comme le temps de réaction ou la quantité de réactifs utilisée a été étudiée. Dans un second temps, une étude des différentes propriétés conférées au papier par les réactions a été réalisée à partir d'une série de tests papetiers optiques et physiques. Mots Clés Click chemistry, Huisgen, CuAAC, propargylation, tosylation, azidation, cellulose, pâte kraft, milieu aqueux, papier.

  5. Etude des cas: Gestion alternatîves des conflits

    OpenAIRE

    Lo, H.

    2006-01-01

    Metadata only record Pour mieux consolider les acquis consensuels pour la gestion alternative des conflits, il nous paraît essentiel de maîtriser un certain nombre de facteurs ayant trait au "partage" des gommeraies entre autres: Available in SANREM office, FS

  6. Conception et évaluation centrée utilisateur d'une technologie innovante au service de l'autonomie et du handicap : « VIGI-SORE » - Dispositif embarqué de prévention des escarres.

    OpenAIRE

    Hlavackova, Petra; Chenu, Olivier; Payan, Yohan; Diot, Bruno; Cannard, Francis; Bucki, Marek; Demongeot, Jacques; Vuillerme, Nicolas

    2011-01-01

    International audience; La prévention des escarres chez le blessé médullaire, compte tenu de leur prévalence, des conséquences sur la qualité de vie des personnes atteintes et des coûts de prise en charge, constitue une priorité de santé publique majeure qui n'a pas aujourd'hui de solutions thérapeutiques fiables et satisfaisantes. C'est dans ce contexte médical, sociétal et économique que nous avons mis au point un dispositif de prévention des escarres du blessé médullaire. Nous présentons i...

  7. IMRT treatment planning based on prioritizing prescription goals.

    Science.gov (United States)

    Wilkens, Jan J; Alaly, James R; Zakarian, Konstantin; Thorstad, Wade L; Deasy, Joseph O

    2007-03-21

    Determining the 'best' optimization parameters in IMRT planning is typically a time-consuming trial-and-error process with no unambiguous termination point. Recently we and others proposed a goal-programming approach which better captures the desired prioritization of dosimetric goals. Here, individual prescription goals are addressed stepwise in their order of priority. In the first step, only the highest order goals are considered (target coverage and dose-limiting normal structures). In subsequent steps, the achievements of the previous steps are turned into hard constraints and lower priority goals are optimized, in turn, subject to higher priority constraints. So-called 'slip' factors were introduced to allow for slight, clinically acceptable violations of the constraints. Focusing on head and neck cases, we present several examples for this planning technique. The main advantages of the new optimization method are (i) its ability to generate plans that meet the clinical goals, as well as possible, without tuning any weighting factors or dose-volume constraints, and (ii) the ability to conveniently include more terms such as fluence map smoothness. Lower level goals can be optimized to the achievable limit without compromising higher order goals. The prioritized prescription-goal planning method allows for a more intuitive and human-time-efficient way of dealing with conflicting goals compared to the conventional trial-and-error method of varying weighting factors and dose-volume constraints.

  8. An efficient algorithm for prioritizing NEA physical observations

    Science.gov (United States)

    Cortese, M.; Perozzi, E.; Micheli, M.; Borgia, B.; Dotto, E.; Mazzotta Epifani, E.; Ieva, S.; Barucci, M. A.; Perna, D.

    2017-03-01

    The present near-Earth asteroids (NEA) discovery rate has surpassed 1500 objects per year, thus calling for extensive observation campaigns devoted to physical characterization in order to define successful mitigation strategies in case of possible impactors. A tool is presented which, through a prioritization algorithm, aims to optimize the planning and the execution of NEA physical observations. Two ranking criteria are introduced, Importance and Urgency, accounting for the need of satisfying the two basic observational modes for physical characterization, that is, rapid response and large observing programs, aimed at selecting targets for exploration and mitigation space missions. The resulting tool generates a daily table of observable targets and it can also be run as a stand-alone tool in order to provide future observing opportunities at a specific date of interest. It has been developed and implemented within the framework of the NEOShield-2 EU/HORIZON 2020 Project; the output of the prioritization algorithm is publicly available, in tabular format, on the NEOShield-2 NEO Properties Portal (url href="http://www.neoshield.net/the-neoshield-project/project-activities/neo-properties-portal">http://www.neoshield.net/the-neoshield-project/project-activities/neo-properties-portal), reachable from the main page of the Project website (url href="http://www.neoshield.eu">http://www.neoshield.eu).

  9. A decision analytic approach to exposure-based chemical prioritization.

    Directory of Open Access Journals (Sweden)

    Jade Mitchell

    Full Text Available The manufacture of novel synthetic chemicals has increased in volume and variety, but often the environmental and health risks are not fully understood in terms of toxicity and, in particular, exposure. While efforts to assess risks have generally been effective when sufficient data are available, the hazard and exposure data necessary to assess risks adequately are unavailable for the vast majority of chemicals in commerce. The US Environmental Protection Agency has initiated the ExpoCast Program to develop tools for rapid chemical evaluation based on potential for exposure. In this context, a model is presented in which chemicals are evaluated based on inherent chemical properties and behaviorally-based usage characteristics over the chemical's life cycle. These criteria are assessed and integrated within a decision analytic framework, facilitating rapid assessment and prioritization for future targeted testing and systems modeling. A case study outlines the prioritization process using 51 chemicals. The results show a preliminary relative ranking of chemicals based on exposure potential. The strength of this approach is the ability to integrate relevant statistical and mechanistic data with expert judgment, allowing for an initial tier assessment that can further inform targeted testing and risk management strategies.

  10. A study on prioritizing typical women’s entrepreneur characteristics

    Directory of Open Access Journals (Sweden)

    Ebrahim Ramezani

    2014-07-01

    Full Text Available Entrepreneurship is one of the main pivot of progress and growth of every country. The spread of entrepreneurship particularly the role of women in this category has speeded up today more than any other times. Many of researchers believe that attention to women entrepreneurship plays remarkable role in soundness and safety of nation’s economy. Maybe in Iran less attention has been paid to this matter in proportion to other countries and due to various reasons, there are not many entrepreneur woman. However, employing typical entrepreneur women in various fields of productivity, industrial, commercial, social and cultural and even higher than these, in country’s political issue proves that women’s role is magnificent and in many cases they enjoy higher abilities in portion to men. In this paper, using additive ratio assessment (ARAS as a prioritizing method, eleven entrepreneur women were chosen for prioritizing criteria for measuring a typical women’s entrepreneurship characteristics. The results show that the balance between work and family among criteria are propounded as the highest weight and fulfilling different jobs simultaneously as the lowest weight.

  11. Task Prioritization in Dual-Tasking: Instructions versus Preferences

    Science.gov (United States)

    Jansen, Reinier J.; van Egmond, René; de Ridder, Huib

    2016-01-01

    The role of task prioritization in performance tradeoffs during multi-tasking has received widespread attention. However, little is known on whether people have preferences regarding tasks, and if so, whether these preferences conflict with priority instructions. Three experiments were conducted with a high-speed driving game and an auditory memory task. In Experiment 1, participants did not receive priority instructions. Participants performed different sequences of single-task and dual-task conditions. Task performance was evaluated according to participants’ retrospective accounts on preferences. These preferences were reformulated as priority instructions in Experiments 2 and 3. The results showed that people differ in their preferences regarding task prioritization in an experimental setting, which can be overruled by priority instructions, but only after increased dual-task exposure. Additional measures of mental effort showed that performance tradeoffs had an impact on mental effort. The interpretation of these findings was used to explore an extension of Threaded Cognition Theory with Hockey’s Compensatory Control Model. PMID:27391779

  12. An Adaptive Data Collection Procedure for Call Prioritization

    Directory of Open Access Journals (Sweden)

    Beaumont Jean-Francois

    2014-12-01

    Full Text Available We propose an adaptive data collection procedure for call prioritization in the context of computer-assisted telephone interview surveys. Our procedure is adaptive in the sense that the effort assigned to a sample unit may vary from one unit to another and may also vary during data collection. The goal of an adaptive procedure is usually to increase quality for a given cost or, alternatively, to reduce cost for a given quality. The quality criterion often considered in the literature is the nonresponse bias of an estimator that is not adjusted for nonresponse. Although the reduction of the nonresponse bias is a desirable goal, we argue that it is not a useful criterion to use at the data collection stage of a survey because the bias that can be removed at this stage through an adaptive collection procedure can also be removed at the estimation stage through appropriate nonresponse weight adjustments. Instead, we develop a procedure of call prioritization that, given the selected sample, attempts to minimize the conditional variance of a nonresponse-adjusted estimator subject to an overall budget constraint. We evaluate the performance of our procedure in a simulation study.

  13. How to Identify and Prioritize Psychosocial Factors Impacting Stress Level.

    Directory of Open Access Journals (Sweden)

    Mounia N Hocine

    Full Text Available We develop a methodological approach to identify and prioritize psychosocial factors (stressors requiring priority action to reduce stress levels. Data analysis was carried out on a random sample of 10 000 French employees who completed, during a routine interview with the occupational physician, a 25-item questionnaire about stress levels, as well as a questionnaire about 58 stressors grouped into 5 latent variables: job control, job context, relationships at work, tasks performed and recognition. Our method combines Importance-Performance Analysis, a valuable approach for prioritizing improvements in the quality of services, with Partial Least Squares-Path modeling, a Structural Equation Modeling approach widely applied in psychosocial research. Findings on our data suggest two areas worthy of attention: one with five stressors on which decision makers should concentrate, and another with five stressors that managers should leave alone when acting to reduce stress levels. We show that IPA is robust when answers to questions are dichotomized, as opposed to the initial 6-point Likert scale. We believe that our approach will be a useful tool for experts and decision-makers in the field of stress management and prevention.

  14. The prioritization of open innovation determinants in banking

    Directory of Open Access Journals (Sweden)

    Tornjanski Vesna

    2015-01-01

    Full Text Available The research scope of the paper is prioritization of open innovation determinants in banking industry using an integrated application of qualitative and quantitative methods in the evaluation process. The research methods were implemented to compound the depth of experts' knowledge and experience on the one hand, and the precise mathematical reasoning, on the other, thus creating the objective and accurate basis for effective decision making. The overview of determinants of open innovations in banking industry has been obtained from the literature overview and the Delphi study conducted among 51 experts from banks in Serbia. Fifteen significant determinants within five dimensions were further evaluated through AHP decision-making method to prioritize them toward the development of the open innovation in banking. The research results show that effective application of open innovation in banking lies in formal reinforcement by management to integrate innovation into organizational policies and in designing dual structures that facilitate the initiation and implementation of an innovation, i.e. building an ambidextrous organization. The research findings and results introduced in this paper can be usefully applied and widely used by both academics and practitioners who are interested in applying the open innovation concept in banking industry.

  15. Effects of preference heterogeneity among landowners on spatial conservation prioritization.

    Science.gov (United States)

    Nielsen, Anne Sofie Elberg; Strange, Niels; Bruun, Hans Henrik; Jacobsen, Jette Bredahl

    2017-06-01

    The participation of private landowners in conservation is crucial to efficient biodiversity conservation. This is especially the case in settings where the share of private ownership is large and the economic costs associated with land acquisition are high. We used probit regression analysis and historical participation data to examine the likelihood of participation of Danish forest owners in a voluntary conservation program. We used the results to spatially predict the likelihood of participation of all forest owners in Denmark. We merged spatial data on the presence of forest, cadastral information on participation contracts, and individual-level socioeconomic information about the forest owners and their households. We included predicted participation in a probability model for species survival. Uninformed and informed (included land owner characteristics) models were then incorporated into a spatial prioritization for conservation of unmanaged forests. The choice models are based on sociodemographic data on the entire population of Danish forest owners and historical data on their participation in conservation schemes. Inclusion in the model of information on private landowners' willingness to supply land for conservation yielded at intermediate budget levels up to 30% more expected species coverage than the uninformed prioritization scheme. Our landowner-choice model provides an example of moving toward more implementable conservation planning. © 2016 Society for Conservation Biology.

  16. Speeding disease gene discovery by sequence based candidate prioritization

    Directory of Open Access Journals (Sweden)

    Porteous David J

    2005-03-01

    Full Text Available Abstract Background Regions of interest identified through genetic linkage studies regularly exceed 30 centimorgans in size and can contain hundreds of genes. Traditionally this number is reduced by matching functional annotation to knowledge of the disease or phenotype in question. However, here we show that disease genes share patterns of sequence-based features that can provide a good basis for automatic prioritization of candidates by machine learning. Results We examined a variety of sequence-based features and found that for many of them there are significant differences between the sets of genes known to be involved in human hereditary disease and those not known to be involved in disease. We have created an automatic classifier called PROSPECTR based on those features using the alternating decision tree algorithm which ranks genes in the order of likelihood of involvement in disease. On average, PROSPECTR enriches lists for disease genes two-fold 77% of the time, five-fold 37% of the time and twenty-fold 11% of the time. Conclusion PROSPECTR is a simple and effective way to identify genes involved in Mendelian and oligogenic disorders. It performs markedly better than the single existing sequence-based classifier on novel data. PROSPECTR could save investigators looking at large regions of interest time and effort by prioritizing positional candidate genes for mutation detection and case-control association studies.

  17. Reconciling global mammal prioritization schemes into a strategy.

    Science.gov (United States)

    Rondinini, Carlo; Boitani, Luigi; Rodrigues, Ana S L; Brooks, Thomas M; Pressey, Robert L; Visconti, Piero; Baillie, Jonathan E M; Baisero, Daniele; Cabeza, Mar; Crooks, Kevin R; Di Marco, Moreno; Redford, Kent H; Andelman, Sandy A; Hoffmann, Michael; Maiorano, Luigi; Stuart, Simon N; Wilson, Kerrie A

    2011-09-27

    The huge conservation interest that mammals attract and the large datasets that have been collected on them have propelled a diversity of global mammal prioritization schemes, but no comprehensive global mammal conservation strategy. We highlight some of the potential discrepancies between the schemes presented in this theme issue, including: conservation of species or areas, reactive and proactive conservation approaches, conservation knowledge and action, levels of aggregation of indicators of trend and scale issues. We propose that recently collected global mammal data and many of the mammal prioritization schemes now available could be incorporated into a comprehensive global strategy for the conservation of mammals. The task of developing such a strategy should be coordinated by a super-partes, authoritative institution (e.g. the International Union for Conservation of Nature, IUCN). The strategy would facilitate funding agencies, conservation organizations and national institutions to rapidly identify a number of short-term and long-term global conservation priorities, and act complementarily to achieve them.

  18. IMRT treatment planning based on prioritizing prescription goals

    Science.gov (United States)

    Wilkens, Jan J.; Alaly, James R.; Zakarian, Konstantin; Thorstad, Wade L.; Deasy, Joseph O.

    2007-03-01

    Determining the 'best' optimization parameters in IMRT planning is typically a time-consuming trial-and-error process with no unambiguous termination point. Recently we and others proposed a goal-programming approach which better captures the desired prioritization of dosimetric goals. Here, individual prescription goals are addressed stepwise in their order of priority. In the first step, only the highest order goals are considered (target coverage and dose-limiting normal structures). In subsequent steps, the achievements of the previous steps are turned into hard constraints and lower priority goals are optimized, in turn, subject to higher priority constraints. So-called 'slip' factors were introduced to allow for slight, clinically acceptable violations of the constraints. Focusing on head and neck cases, we present several examples for this planning technique. The main advantages of the new optimization method are (i) its ability to generate plans that meet the clinical goals, as well as possible, without tuning any weighting factors or dose-volume constraints, and (ii) the ability to conveniently include more terms such as fluence map smoothness. Lower level goals can be optimized to the achievable limit without compromising higher order goals. The prioritized prescription-goal planning method allows for a more intuitive and human-time-efficient way of dealing with conflicting goals compared to the conventional trial-and-error method of varying weighting factors and dose-volume constraints.

  19. IMRT treatment planning based on prioritizing prescription goals

    Energy Technology Data Exchange (ETDEWEB)

    Wilkens, Jan J [Department of Radiation Oncology, Washington University School of Medicine, and Siteman Cancer Center, Saint Louis, MO (United States); Alaly, James R [Department of Radiation Oncology, Washington University School of Medicine, and Siteman Cancer Center, Saint Louis, MO (United States); Zakarian, Konstantin [Department of Radiation Oncology, Washington University School of Medicine, and Siteman Cancer Center, Saint Louis, MO (United States); Thorstad, Wade L [Department of Radiation Oncology, Washington University School of Medicine, and Siteman Cancer Center, Saint Louis, MO (United States); Deasy, Joseph O [Department of Radiation Oncology, Washington University School of Medicine, and Siteman Cancer Center, Saint Louis, MO (United States)

    2007-03-21

    Determining the 'best' optimization parameters in IMRT planning is typically a time-consuming trial-and-error process with no unambiguous termination point. Recently we and others proposed a goal-programming approach which better captures the desired prioritization of dosimetric goals. Here, individual prescription goals are addressed stepwise in their order of priority. In the first step, only the highest order goals are considered (target coverage and dose-limiting normal structures). In subsequent steps, the achievements of the previous steps are turned into hard constraints and lower priority goals are optimized, in turn, subject to higher priority constraints. So-called 'slip' factors were introduced to allow for slight, clinically acceptable violations of the constraints. Focusing on head and neck cases, we present several examples for this planning technique. The main advantages of the new optimization method are (i) its ability to generate plans that meet the clinical goals, as well as possible, without tuning any weighting factors or dose-volume constraints, and (ii) the ability to conveniently include more terms such as fluence map smoothness. Lower level goals can be optimized to the achievable limit without compromising higher order goals. The prioritized prescription-goal planning method allows for a more intuitive and human-time-efficient way of dealing with conflicting goals compared to the conventional trial-and-error method of varying weighting factors and dose-volume constraints.

  20. Split diversity in constrained conservation prioritization using integer linear programming.

    Science.gov (United States)

    Chernomor, Olga; Minh, Bui Quang; Forest, Félix; Klaere, Steffen; Ingram, Travis; Henzinger, Monika; von Haeseler, Arndt

    2015-01-01

    Phylogenetic diversity (PD) is a measure of biodiversity based on the evolutionary history of species. Here, we discuss several optimization problems related to the use of PD, and the more general measure split diversity (SD), in conservation prioritization.Depending on the conservation goal and the information available about species, one can construct optimization routines that incorporate various conservation constraints. We demonstrate how this information can be used to select sets of species for conservation action. Specifically, we discuss the use of species' geographic distributions, the choice of candidates under economic pressure, and the use of predator-prey interactions between the species in a community to define viability constraints.Despite such optimization problems falling into the area of NP hard problems, it is possible to solve them in a reasonable amount of time using integer programming. We apply integer linear programming to a variety of models for conservation prioritization that incorporate the SD measure.We exemplarily show the results for two data sets: the Cape region of South Africa and a Caribbean coral reef community. Finally, we provide user-friendly software at http://www.cibiv.at/software/pda.

  1. Falsification or Confirmation: From Logic to Psychology

    CERN Document Server

    Lukyanenko, Roman

    2015-01-01

    Corroboration or confirmation is a prominent philosophical debate of the 20th century. Many philosophers have been involved in this debate most notably the proponents of confirmation led by Hempel and its most powerful criticism by the falsificationists led by Popper. In both cases however the debates were primarily based on the arguments from logic. In this paper we review these debates and suggest that a different perspective on falsification versus confirmation can be taken by grounding arguments in cognitive psychology.

  2. Missile Aerodynamics (Aerodynamique des Missiles)

    Science.gov (United States)

    1998-11-01

    guerre froide la production des missiles a baisse’, avec pour consequence une diminution des budgets de d6veloppement. Les nouveaux types de conflits ...Roma) Directeur - Gestion de l’information LUXEMBOURG (Recherche et developpement) - DRDGI 3 Voir Belgique Ministbre de la Difense nationale NORVEGE

  3. Generic Prioritization Framework For Target Selection And Instrument Usage For Reconnaissance Mission Autonomy

    OpenAIRE

    Fink, Wolfgang

    2006-01-01

    A generic prioritization framework is introduced for addressing the problem of automated prioritization of target selection and instrument usage, applicable to Earth and Space reconnaissance missions. The framework is based on the assumptions that clustering of preliminary data for identified targets within an operational area has occurred and that the clustering quality can be expressed as an objective function. Target prioritization then means to rank targets accordi...

  4. Prioritization and selection of parameters for control chart implementation based on technical criticality and cost criticality

    Directory of Open Access Journals (Sweden)

    Sirintra Tan-intara-art

    2013-07-01

    Full Text Available An important problem in control chart implementation is the availability of resources to collect and analyze data for control charts implementation. This paper proposes a method to prioritize and select final product parameters to control. The prioritization is based on cost of quality and technical criticality of those parameters. The prioritization method is demonstrated by a case study of flexible printed circuit manufacturing.

  5. Prioritizing the patient voice in the development of urologic oncology research.

    Science.gov (United States)

    Filippou, Pauline; Smith, Angela B

    2017-09-01

    Prioritization of patient and stakeholder engagement in the research process has been realized through increased funding and policy directives at the government level. Particularly, patient engagement in the preparatory research stage has driven development of patient-prioritized research questions. In this article, a successful example of patient-centered research prioritization is reviewed, and effective strategies and opportunities for patient engagement in urologic oncology research are described. Copyright © 2017 Elsevier Inc. All rights reserved.

  6. Therapie des Status epilepticus

    Directory of Open Access Journals (Sweden)

    Trinka E

    2009-01-01

    Full Text Available Der Status epilepticus (SE ist nach dem Schlaganfall der häufigste neurologische Notfall. Er stellt als generaliserter konvulsiver SE (GKSE die schwerste Ausprägung eines epileptischen Anfalls dar, der mit einer signifikanten Morbidität und einer ca. 20%igen Letalität verbunden ist. Nur bei der Hälfte der Patienten mit SE besteht zuvor eine Epilepsie; die meisten Fälle sind symptomatisch, wobei Schädel- Hirn-Traumata, zerebrovaskuläre Erkrankungen, ZNS-Infektionen und metabolische Ursachen führend sind. Bei Patienten mit vorbestehender Epilepsie lässt sich eine frühe Phase des GKSE erkennen, in der die Anfälle crescendoartig zunehmen, bis sie in kontinuierliche Anfallsaktivität münden (etablierte Phase. Das Management eines GKSE verlangt rasches und beherztes Vorgehen. Neben der sofort einzuleitenden Therapie muss gleichzeitig die artdiagnostische Zuordnung des SE und die Ursache erkannt und behandelt werden. Als Therapie der ersten Wahl sind Benzodiazepine etabliert, wobei intravenösem (i.v. Lorazepam gegenüber Diazepam der Vorzug zu geben ist. Versagt die Therapie mit Benzodiazepinen, muss rasch und konsequent nach einem Stufenschema vorgegangen werden. Phenytoin/Fosphenytoin, Valproinsäure, Levetiracetam und Lacosamid sind als i.v. Formulierung erhältliche Antiepileptika. Obwohl Vergleichsstudien hier fehlen, wird Phenytoin bevorzugt. Valproat und Levetiracetam sind nicht sedierend und kardiovaskulär gut verträglich, sodass hier Alternativen zu Phenytoin vorhanden sind. Lacosamid ist eine neue Therapieoption, deren Stellenwert erst bestimmt werden muss. Versagt auch die zweite Therapiestufe, so muss der Patient intubiert und in Allgemeinanästhesie intensivmedizinisch behandelt werden. Dafür stehen Thiopental, Propofol oder hoch dosiertes Midazolam zu Verfügung. Durch den eklatanten Mangel an randomisierten Studien bleibt die Therapie des GKSE empirisch und durch den Off-label-Einsatz gekennzeichnet.

  7. Mécanique des fluides

    CERN Document Server

    Cengel, Y A

    2017-01-01

    La mécanique des fluides est un outil performant qui permet d'expliquer les phénomènes qui nous entourent de l'échelle microscopique à l'échelle macroscopique. Elle est aussi à la base du développement de nombreuses technologies. Cet ouvrage à destination des étudiants donne une vision complète de la mécanique des fluides. Bien que la mécanique des fluides puisse souvent paraître rébarbative aux yeux des étudiants, cet ouvrage valorise ce domaine d'enseignement en l'illustrant de nombreux exemples issus de l'ingénierie navale, l'aéronautique, la météorologie, etc.

  8. MRI of the fetal abdomen; MRT des fetalen Abdomens

    Energy Technology Data Exchange (ETDEWEB)

    Hoermann, M.; Brugger, P.C.; Witzani, L.; Prayer, D. [Medizinische Universitaet Wien (Austria). Universitaetsklinik fuer Radiodiagnostik

    2006-02-15

    Magnetic resonance imaging (MRI) is an important diagnostic component for central nervous system and thoracic diseases during fetal development. Although ultrasound remains the method of choice for observing the fetus during pregnancy, fetal MRI is being increasingly used as an additional technique for the accurate diagnosis of abdominal diseases. Recent publications confirm the value of MRI in the diagnosis of fetal gastrointestinal tract and urogenital system diseases. The following report provides an overview of MRI-examination techniques for the most frequent diseases of the abdomen. (orig.) [German] Die MRT ist ein wichtiger Bestandteil zur Diagnostik des zentralen Nervensystems und thorakaler Erkrankungen in der fetalen Entwicklung. Wenngleich der Ultraschall die Methode der Wahl zur Ueberwachung des Feten in der Schwangerschaft bleibt, bekommt die fetale MRT als zusaetzliche Untersuchungstechnik zur akkuraten Diagnostik abdomineller Erkrankungen immer groessere Bedeutung. Die neueren Publikationen bestaetigen v. a. den Stellenwert der MRT in der Diagnose von Erkrankungen des fetalen Gastrointestinaltrakts und des Urogenitalsystems. Im Folgenden soll ein Ueberblick ueber die MR-Untersuchungstechnik der haeufigsten Erkrankungen des Abdomens gegeben werden. (orig.)

  9. Comprendre l'influence des facteurs contextuels sur la participation communiautaire à la santé

    DEFF Research Database (Denmark)

    Sombie, Issa; Ilboudo, Sidbewendin David Olivier; Soubeiga, André Kamba

    2015-01-01

    Le Burkina Faso met en œuvre depuis plusieurs années la stratégie de la participation communautaire. Des comités de gestion (CoGes) ont été mis en place dans les centres de santé de la première ligne et doivent participer aux prises de décisions. L’objectif principal de cette stratégie est de...... organisations communautaires, les rivalités inter-villages et les conflits coutumiers. L’étude relève également que les communautés ne perçoivent pas leur implication dans le processus décisionnel des services de santé comme une priorité. Leurs principales attentes s’orientent vers la disponibilité de soins de...

  10. Molekulare Formen des PSA in der Diagnostik des Prostatakarzinoms

    Directory of Open Access Journals (Sweden)

    Lein M

    2003-01-01

    Full Text Available Das prostataspezifische Antigen ist die wichtigste Kenngröße in der Diagnostik und Therapieüberwachung des Prostatakarzinoms. Zur besseren Abgrenzung zwischen Männern mit und ohne Prostatakarzinom, aber auch zur Früherkennung, haben sich die molekularen Formen des PSA als wertvolle Entscheidungshilfen erwiesen. Es wird eine Übersicht über bisher vorliegende Informationen zur Aussagekraft des freien PSA, des an alpha 1-Antichymotrypsin gebundenen PSA und des komplexierten PSA (cPSA zusammen mit eigenen Resultaten gegeben. Der Quotient aus freiem und Gesamt-PSA hat sich als eine wichtige Entscheidungsgröße in der urologischen Praxis etabliert, mit der Sensitivität und Spezifität der Prostatakarzinomdiagnostik verbessert werden. Die Zahl von Prostatastanzbiopsien im Gesamt-PSA-Bereich von 4–10 ng/ml kann damit reduziert werden. Ein diagnostischer Vorteil der alleinigen Bestimmung des komplexierten PSA bzw. der entsprechenden Quotienten im Vergleich zum Gesamt-PSA und des Quotienten freies PSA zu Gesamt-PSA konnte bisher nicht sicher nachgewiesen werden.

  11. Mécanique des sols et des roches

    CERN Document Server

    Vullier, Laurent; Zhao, Jian

    2016-01-01

    La mécanique des sols et la mécanique des roches sont des disciplines généralement traitées séparément dans la littérature. Pour la première fois, un traité réunit ces deux spécialités, en intégrant également les connaissances en lien avec les écoulements souterrains et les transferts thermiques. A la fois théorique et pratique, cet ouvrage propose tout d'abord une description détaillée de la nature et de la composition des sols et des roches, puis s'attache à la modélisation de problèmes aux conditions limites et présente les essais permettant de caractériser les sols et les roches, tant d'un point de vue mécanique qu'hydraulique et thermique. La problématique des sols non saturés et des écoulements multiphasiques est également abordée. Une attention particulière est portée aux lois de comportement mécanique et à la détermination de leurs paramètres par des essais in situ et en laboratoire, et l'ouvrage offre également une présentation détaillée des systèmes de classi...

  12. NASA Astrophysics Prioritizes Technology Development Funding for Strategic Missions

    Science.gov (United States)

    Thronson, Harley A.; Pham, Bruce; Ganel, Opher

    2017-01-01

    The Cosmic Origins (COR) and Physics of the Cosmos (PCOS) Program Offices (POs) reside at NASA GSFC and implement priorities for the NASA HQ Astrophysics Division (APD). One major aspect of the POs’ activities is managing our Strategic Astrophysics Technology (SAT) program to mature technologies for future strategic missions. The Programs follow APD guidance on which missions are strategic, currently informed by the NRC’s 2010 Decadal Survey report, as well as APD’s Implementation Plan and the Astrophysics Roadmap.In preparation for the upcoming 2020 Decadal Survey, the APD has established Science and Technology Definition Teams (STDTs) to study four large-mission concepts: the Origins Space Telescope, Habitable Exoplanet Imaging Mission, Large UV/Optical/IR Surveyor, and X-ray Surveyor. The STDTs will develop the science case and design reference mission, assess technology development needs, and estimate the cost of their concept. A fifth team, the L3 Study Team (L3ST), was charged to study potential US contributions to ESA’s planned L3 gravitational-wave observatory.The POs use a rigorous and transparent process to solicit technology gaps from the scientific and technical communities, and prioritize those entries based on strategic alignment, expected impact, cross-cutting applicability, and urgency. Starting in 2016, the technology-gap assessments of the four STDTs and the L3ST are included in our process. Until a study team submits its final report, community-proposed changes to gaps submitted or adopted by a study team are forwarded to that study team for consideration.We discuss our technology development process, with strategic prioritization informing calls for SAT proposals and informing investment decisions. We also present results of this year’s technology gap prioritization and showcase our current portfolio of technology development projects. To date, 77 COR and 80 PCOS SAT proposals have been received, of which 18 COR and 22 PCOS projects

  13. Le silence des agneaux

    Directory of Open Access Journals (Sweden)

    BERNARD ROY

    2012-01-01

    Full Text Available Ce texte est avant tout une réflexion sur la notion d'obéissance, initiée à partir de deux évènements impliquant étroitement des membres de la profession infirmière. L'auteur se réjouit de la prise de parole et de l'implication directe d'infirmières dans le contexte du printemps érable. Il estime que la posture de ces infirmières s'inscrit dans ce que l'éthicien Guy Durand, appelle une obéissance autonome qui peut, du coup, mener à la désobéissance civile, à l'objection de conscience. En prenant exemple sur le silence des infirmières dans le contexte de la fermeture de postes d'infirmières en Minganie, l'auteur estime que cette posture est marginale chez les infirmières qui, majoritairement, adoptent une position de soumission et d'obéissance hétéronome.

  14. La médicalisation des humeurs des enfants

    OpenAIRE

    Monzée, Joël

    2015-01-01

    Les enfants qui ont des comportements dérangeants ou qui souffrent de problèmes neurologiques, comme le trouble déficitaire de l’attention avec ou sans hyperactivité (TDAH), remettent en question nos moyens d’intervention pour les aider. Alors que le contexte européen tend à privilégier une intervention psychoéducative, les milieux nord-américains recourent davantage aux psychostimulants pour réduire les effets des problèmes comportementaux des enfants. Cet article aborde quelques problématiq...

  15. Expression, receptor binding, and biophysical characterization of guinea pig insulin desB30

    DEFF Research Database (Denmark)

    Engholm, Ebbe; Hansen, Thomas Hesselhøj; Johansson, Eva;

    2015-01-01

    not indicate the formation of any larger structures of GI desB30 in the presence of various divalent metal ions, but did indicate that GI desB30 has an affinity towards Mn, Co, and Cu ions. Finally, the low affinity for the insulin receptor and the very low affinity for the IGF-I receptor by GI desB30 were......Here we report, for the first time, the heterologous expression of desB30 guinea pig insulin (GI desB30) in the yeast Saccharomyces cerevisiae. The affinities of GI desB30 for the insulin receptor A and the IGF-I receptor were also quantified for the first time. Small-angle X-ray scattering...... and analytical ultracentrifugation studies confirmed that GI desB30 did not form dimers or hexamers, in contrast to human insulin. Sizeexclusion chromatography connected to inductively coupled plasma mass spectrometry revealed that GI desB30 has affinity towards several divalent metal ions. These studies did...

  16. Discovery of the Lensed Quasar System DES J0408-5354

    Energy Technology Data Exchange (ETDEWEB)

    Lin, H.; et al.

    2017-01-31

    We report the discovery and spectroscopic confirmation of the quad-like lensed quasar system DES J0408-5354 found in the Dark Energy Survey (DES) Year 1 (Y1) data. This system was discovered during a search for DES Y1 strong lensing systems using a method that identified candidates as red galaxies with multiple blue neighbors. DES J0408-5354 consists of a central red galaxy surrounded by three bright (i < 20) blue objects and a fourth red object. Subsequent spectroscopic observations using the Gemini South telescope confirmed that the three blue objects are indeed the lensed images of a quasar with redshift z = 2.375, and that the central red object is an early-type lensing galaxy with redshift z = 0.597. DES J0408-5354 is the first quad lensed quasar system to be found in DES and begins to demonstrate the potential of DES to discover and dramatically increase the sample size of these very rare objects.

  17. Prioritization of natural phenomena hazards evaluations for CHG facilities

    CERN Document Server

    Graves, C E

    2001-01-01

    Natural phenomena hazards (NPH) are unexpected acts of nature that pose a threat or danger to workers, the public or to the environment by potential damage to structures, systems and components (SSCs). Earthquakes, extreme winds (hurricane and tornado), flood, volcanic eruption, lightning strike, or extreme cold or heat are examples of NPH. This document outlines the method used to prioritize buildings for inspection following an NPH event and contains the priority list for CH2M HILL Hanford Group, Inc. (CHG) buildings. Once an NPH event occurs and the Hanford Emergency Operations Center (EOC) is activated, this document will be used by the EOC to assign building inspections for the trained evaluators, barring any information from the field.

  18. Place prioritization for biodiversity content using species ecological niche modeling

    Directory of Open Access Journals (Sweden)

    Víctor Sánchez-Cordero

    2005-01-01

    Full Text Available Place prioritization for biodiversity representation is essential for conservation planning, particularly in megadiverse countries where high deforestation threatens biodiversity. Given the collecting biases and uneven sampling of biological inventories, there is a need to develop robust models of species’ distributions. By modeling species’ ecological niches using point occurrence data and digitized environmental feature maps, we can predict potential and extant distributions of species in untransformed landscapes, as well as in those transformed by vegetation change (including deforestation. Such distributional predictions provide a framework for use of species as biodiversity surrogates in place prioritization procedures such as those based on rarity and complementarity. Beyond biodiversity conservation, these predictions can also be used for place prioritization for ecological restoration under current conditions and under future scenarios of habitat change (e.g., deforestation scenarios. To illustrate these points, we (1 predict distributions under current and future deforestation scenarios for the Mexican endemic mammal Dipodomys phillipsii, and show how areas for restoration may be selected; and (2 propose conservation areas by combining nonvolant mammal distributional predictions as biodiversity surrogates with place prioritization procedures, to connect decreed natural protected areas in a region holding exceptional biodiversity: the Transvolcanic Belt in central Mexico. La selección de áreas prioritarias de conservación es fundamental en la planeación sistemática de la conservación, particularmente en países de mega-diversidad, en donde la alta deforestación es una de las amenazas a la biodiversidad. Debido a los sesgos taxonómicos y geográficos de colecta de los inventarios biológicos, es indispensable generar modelos robustos de distribución de especies. Al modelar el nicho ecológico de especies usando localidades de

  19. Prioritization of the National Dental Hygiene Research Agenda.

    Science.gov (United States)

    Gadbury-Amyot, Cynthia C; Doherty, Frances; Stach, Donna J; Wyche, Charlotte J; Connolly, Irene; Wilder, Rebecca

    2002-01-01

    The profession of dental hygiene has made considerable progress over the past 30 years toward developing a unique body of knowledge for guiding education, practice, and research. The 1993-1994 American Dental Hygienists' Association Council on Research published the first national dental hygiene research agenda in 1994. The 1994 research agenda focused dental hygienists' research efforts; however, publication of two national reports--the Surgeon General's Report on Oral Health, and Healthy People 2010--have made it necessary to revisit the research agenda. After considering input from participants in the Fourth National Dental Hygiene Research Conference and evaluating the Surgeon General's Report, the 2000-2001 Council on Research has established recommendations for the prioritization of the 1993-1994 research agenda. This report outlines for readers the rationale for the proposed recommendations.

  20. A multicriteria prioritization model to support public safety planning

    Directory of Open Access Journals (Sweden)

    André Morais Gurgel

    2013-08-01

    Full Text Available Setting out to solve operational problems is a frequent part of decision making on public safety. However, the pillars of tactics and strategy are normally disregarded. Thus, this paper focuses on a strategic issue, namely that of a city prioritizing areasin which there is a degree of occurrences for criminality to increase. A multiple criteria approach is taken. The reason for this is that such a situation is normally analyzed from the perspective of the degree of police occurrences. The proposed model is based on a SMARTS multicriteria method and was applied in a Brazilian City. It combines a multicriteria method and a Monte Carlo Simulation to support an analysis of robustness. As a result, we highlight some differences between the model developed and police occurrences model. It might support differentiated policies for zones, by indicating where there should be strong actions, infrastructure investments, monitoring procedures and others public safety policies.

  1. Sustainability as the key to prioritize investments in public infrastructures

    Energy Technology Data Exchange (ETDEWEB)

    Pardo-Bosch, Francesc, E-mail: francesc.pardo@upc.edu [Departament d' Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya - Barcelona Tech. (Spain); Political Science Department, University of California - Berkeley (United States); Aguado, Antonio, E-mail: antonio.aguado@upc.edu [Departament d' Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya - Barcelona Tech. (Spain)

    2016-09-15

    Infrastructure construction, one of the biggest driving forces of the economy nowadays, requires a huge analysis and clear transparency to decide what projects have to be executed with the few resources available. With the aim to provide the public administrations a tool with which they can make their decisions easier, the Sustainability Index of Infrastructure Projects (SIIP) has been defined, with a multi-criteria decision system called MIVES, in order to classify non-uniform investments. This index evaluates, in two inseparable stages, the contribution to the sustainable development of each infrastructure project, analyzing its social, environmental and economic impact. The result of the SIIP allows to decide the order with which projects will be prioritized. The case of study developed proves the adaptability and utility of this tool for the ordinary budget management.

  2. Prioritizing the Risk Factors of Severe Early Childhood Caries

    Directory of Open Access Journals (Sweden)

    Noha Samir Kabil

    2017-01-01

    Full Text Available Severe early childhood caries remains the most common chronic disease affecting children. The multifactorial etiology of caries has established a controversy about which risk factors were more significant to its development. Therefore, our study aimed through meticulous statistical analysis to arrange the “well agreed upon” common risk factors in order of significance, to aid the clinician in tailoring an adequate preventive program. The study prioritized or reshuffled the risk factors contributing to severe early childhood caries and placed them in the order of their significance as follows: snacking of sugary food several times a day, increased number of siblings to three or more, night feeding, child self-employed brushing, mother’s caries experience, two siblings, on demand feeding, once/day sugary food, sharing utensils, one sibling, male gender, father’s education, late first dental visit, brushing time, mother’s education, no dental visit, decreased brushing frequency, and no night brushing.

  3. CONSOLIDATING BATCH AND TRANSACTIONAL WORKLOADS USING DEPENDENCY STRUCTURE PRIORITIZATION

    Directory of Open Access Journals (Sweden)

    S.NIVETHITHA

    2013-04-01

    Full Text Available Organizations offer efficient services to their customers through cloud. These services can either be a batch or transactional workloads. To offer a real-time service, there comes a need to schedule these workloads in an efficient way. An idea to consolidate these workloads enables us to cut down the energy consumption and infrastructure cost. It will be harder to consolidate both these workloads due to the difference in their nature, performance goals and control mechanisms. The proposed work implements the concept of Dependency Structure Prioritization (DSP to assign priority to the job. This work tends to make effective resource utilization through reducing the number of job migration and missed deadline jobs by considering the deadline and the priority of the job as the most important evaluation factor.

  4. Prioritizing research to reduce youth suicide and suicidal behavior.

    Science.gov (United States)

    Bridge, Jeffrey A; Horowitz, Lisa M; Fontanella, Cynthia A; Grupp-Phelan, Jackie; Campo, John V

    2014-09-01

    The goal of the National Action Alliance for Suicide Prevention is to reduce suicide and suicide attempts in the U.S. by 40% in the next decade. In this paper, a public health approach is applied to suicide prevention to illustrate how reductions in youth suicide and suicidal behavior might be achieved by prioritizing research in two areas: (1) increasing access to primary care-based behavioral health interventions for depressed youth and (2) improving continuity of care for youth who present to emergency departments after a suicide attempt. Finally, some scientific, clinical, and methodologic breakthroughs needed to achieve rapid, substantial, and sustained reductions in youth suicide and suicidal behavior are discussed. Copyright © 2014 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

  5. Prioritized efficiency optimization for intensity modulated proton therapy

    Science.gov (United States)

    Müller, Birgit S.; Wilkens, Jan J.

    2016-12-01

    A high dosimetric quality and short treatment time are major goals in radiotherapy planning. Intensity modulated proton therapy (IMPT) plans obtain dose distributions of great conformity but often result in long delivery times which are typically not incorporated into the optimization process. We present an algorithm to optimize delivery efficiency of IMPT plans while maintaining plan quality, and study the potential trade-offs of these interdependent objectives. The algorithm is based on prioritized optimization, a stepwise approach to implemented objectives. First the quality of the plan is optimized. The second step of the prioritized efficiency optimization (PrEfOpt) routine offers four alternatives for reducing delivery time: minimization of the total spot weight sum (A), maximization of the lowest spot intensity of each energy layer (B), elimination of low-weighted spots (C) or energy layers (D). The trade-off between dosimetric quality (step I) and treatment time (step II) is controlled during the optimization by option-dependent parameters. PrEfOpt was applied to a clinical patient case, and plans for different trade-offs were calculated. Delivery times were simulated for two virtual facilities with constant and variable proton current, i.e. independent and dependent on the optimized spot weight distributions. Delivery times decreased without major degradation of plan quality; absolute time reductions varied with the applied method and facility type. Minimizing the total spot weight sum (A) reduced times by 28% for a similar plan quality at a constant current (changes of minimum dose in the target  process can yield reduced delivery times with similar plan qualities. A potential clinical application of PrEfOpt is the generation of multiple plans with different trade-offs for a multicriteria optimization setting. Then, the planner can select the preferred compromise between treatment time and quality for each individual patient.

  6. Postprandial exercise: prioritization or additivity of the metabolic responses?

    Science.gov (United States)

    Bennett, A F; Hicks, J W

    2001-06-01

    Monitor lizards (Varanus exanthematicus) were used to examine the prioritization or additivity of the metabolic responses associated with exercise and digestion, either of which can elevate metabolic rate independently. Rates of oxygen consumption (V(O2)) and ventilation (V(E)) were measured in lizards during fasting exercise, postprandial rest and postprandial exercise. In fasting animals, V(O2) increased with walking speed to a maximal value of 15.9 ml O(2)kg(-1)min(-1) at 1.25 km h(-1). Postprandial resting metabolic rate was elevated significantly above fasting levels (4.1 versus 2.0 ml O(2)kg(-1)min(-1)). During postprandial exercise, V(O2) increased to a maximal value of 18.8 ml O(2)kg(-1)min(-1) at 1.25 km h(-1). At every level of exercise, V(O2) was significantly higher in postprandial animals by a similar increment; the maximal rate of oxygen consumption was significantly increased by 18% in postprandial individuals. Maximal V(E) did not differ in fasting and postprandial animals and, therefore, the greater V(O2)(max) of postprandial animals cannot be attributed to a higher ventilation rate. Air convection requirement (V(E)/V(O2)) is significantly lower in postprandial animals at rest and at all levels of exercise, indicating a relative hypoventilation and increased pulmonary oxygen extraction efficiency. We suggest that this increased oxygen extraction may be due to decreased cardiopulmonary shunts and/or to lower mixed venous oxygen content. The data unequivocally support an additivity model rather than prioritization models for the allocation of elevated metabolic rate: the postprandial metabolic increment is not suspended during exercise, but rather is added onto the cost of exercise. It is clear that fasting exercise did not elicit truly maximal levels of cardiopulmonary oxygen transport in these animals, indicating problems for design models that make this assumption.

  7. Agricultural pesticide usage and prioritization in South Korea.

    Science.gov (United States)

    Cha, Eun Shil; Jeong, Mihye; Lee, Won Jin

    2014-01-01

    This study aims to review agricultural pesticide usage and trends and to identify hazardous pesticides for regulation, in terms of public health, in South Korea. The authors collected data on usage and trends of agricultural pesticides through agriculture-related databases. Criteria from the US Environmental Protection Agency classification for carcinogenicity, World Health Organization classification for acute toxicity, and European Union prioritization list for endocrine-disrupting chemicals were used for the hazard categorization of identified individual active ingredients. Pesticides to be prioritized among all pesticides used in South Korea between 2007 and 2011 were selected by taking into account the volume of usage, toxicity, and epidemiological evidence. Annual agricultural use of pesticides has increased rapidly from the 1970s to 1990s in South Korea, but has declined since 2001. The quantity of pesticides used in 2011 was reported as 19,131 tons, and was comprised of 34.7% insecticides, 28.0% fungicides, and 27.1% herbicides. The 50 pesticides with the greatest volume of usage accounted for 82.6% of the total volume of pesticides used between 2007 and 2011, with the most-used active ingredient being machine oil, followed by mancozeb and then paraquat. Organophosphates were the most used among the top 50 pesticides. A total of 24 pesticides were selected for recommendation of intensive regulation in South Korea. In conclusion, the authors described the usage and trends of overall agricultural pesticides, which would serve as a fundamental step forward in managing pesticide in terms of public health. Intensive efforts are required for the prevention of potential health effects from the 24 identified pesticides.

  8. Timbre Brownfield Prioritization Tool to support effective brownfield regeneration.

    Science.gov (United States)

    Pizzol, Lisa; Zabeo, Alex; Klusáček, Petr; Giubilato, Elisa; Critto, Andrea; Frantál, Bohumil; Martinát, Standa; Kunc, Josef; Osman, Robert; Bartke, Stephan

    2016-01-15

    In the last decade, the regeneration of derelict or underused sites, fully or partly located in urban areas (or so called "brownfields"), has become more common, since free developable land (or so called "greenfields") has more and more become a scare and, hence, more expensive resource, especially in densely populated areas. Although the regeneration of brownfield sites can offer development potentials, the complexity of these sites requires considerable efforts to successfully complete their revitalization projects and the proper selection of promising sites is a pre-requisite to efficiently allocate the limited financial resources. The identification and analysis of success factors for brownfield sites regeneration can support investors and decision makers in selecting those sites which are the most advantageous for successful regeneration. The objective of this paper is to present the Timbre Brownfield Prioritization Tool (TBPT), developed as a web-based solution to assist stakeholders responsible for wider territories or clusters of brownfield sites (portfolios) to identify which brownfield sites should be preferably considered for redevelopment or further investigation. The prioritization approach is based on a set of success factors properly identified through a systematic stakeholder engagement procedure. Within the TBPT these success factors are integrated by means of a Multi Criteria Decision Analysis (MCDA) methodology, which includes stakeholders' requalification objectives and perspectives related to the brownfield regeneration process and takes into account the three pillars of sustainability (economic, social and environmental dimensions). The tool has been applied to the South Moravia case study (Czech Republic), considering two different requalification objectives identified by local stakeholders, namely the selection of suitable locations for the development of a shopping centre and a solar power plant, respectively. The application of the TBPT to

  9. A methodology for comprehensive strategic planning and program prioritization

    Science.gov (United States)

    Raczynski, Christopher Michael

    2008-10-01

    This process developed in this work, Strategy Optimization for the Allocation of Resources (SOAR), is a strategic planning methodology based off Integrated Product and Process Development and systems engineering techniques. Utilizing a top down approach, the process starts with the creation of the organization vision and its measures of effectiveness. These measures are prioritized based on their application to external world scenarios which will frame the future. The programs which will be used to accomplish this vision are identified by decomposing the problem. Information is gathered on the programs as to the application, cost, schedule, risk, and other pertinent information. The relationships between the levels of the hierarchy are mapped utilizing subject matter experts. These connections are then utilized to determine the overall benefit of the programs to the vision of the organization. Through a Multi-Objective Genetic Algorithm a tradespace of potential program portfolios can be created amongst which the decision maker can allocate resources. The information and portfolios are presented to the decision maker through the use of a Decision Support System which collects and visualizes all the data in a single location. This methodology was tested utilizing a science and technology planning exercise conducted by the United States Navy. A thorough decomposition was defined and technology programs identified which had the potential to provide benefit to the vision. The prioritization of the top level capabilities was performed through the use of a rank ordering scheme and a previous naval application was used to demonstrate a cumulative voting scheme. Voting was performed utilizing the Nominal Group Technique to capture the relationships between the levels of the hierarchy. Interrelationships between the technologies were identified and a MOGA was utilized to optimize portfolios with respect to these constraints and information was placed in a DSS. This

  10. Prioritizing research topics: a comparison of crowdsourcing and patient registry.

    Science.gov (United States)

    Truitt, Anjali R; Monsell, Sarah E; Avins, Andrew L; Nerenz, David R; Lawrence, Sarah O; Bauer, Zoya; Comstock, Bryan A; Edwards, Todd C; Patrick, Donald L; Jarvik, Jeffrey G; Lavallee, Danielle C

    2017-04-05

    A cornerstone of patient-centered outcome research is direct patient involvement throughout the research process. Identifying and prioritizing research topics is a critical but often overlooked point for involvement, as it guides what research questions are asked. We assess the feasibility of involving individuals with low back pain in identifying and prioritizing research topics using two approaches: an existing patient registry and an online crowdsourcing platform. We compare and contrast the diversity of participants recruited, their responses, and resources involved. Eligible participants completed a survey ranking their five highest priority topics from an existing list and supplying additional topics not previously identified. We analyzed their responses using descriptive statistics and content analysis. The patient registry yielded older (mean age 72.4), mostly White (70%), and well-educated (95% high school diploma or higher) participants; crowdsourcing yielded younger (mean age 36.6 years), mostly White (82%), and well-educated (98% high school diploma or higher) participants. The two approaches resulted in similar research priorities by frequency. Both provided open-ended responses that were useful, in that they illuminate additional and nuanced research topics. Overall, both approaches suggest a preference towards topics related to diagnosis and treatment over other topics. Using a patient registry and crowdsourcing are both feasible recruitment approaches for engagement. Researchers should consider their approach, community, and resources when choosing their recruitment approach, as each approach has its own strengths and weaknesses. These approaches are likely most appropriate to supplement or to complement in-person and ongoing engagement strategies.

  11. Longer Addiction Treatment Is Better, Study Confirms

    Science.gov (United States)

    ... https://medlineplus.gov/news/fullstory_163911.html Longer Addiction Treatment Is Better, Study Confirms Success rate goes up ... 3, 2017 (HealthDay News) -- The longer patients receive treatment for addiction, the greater their chances of success, a new ...

  12. Habilitations à diriger des recherches

    Directory of Open Access Journals (Sweden)

    2007-04-01

    Full Text Available Pierre Corbin, Avec des dictionnaires pour compagnons.Habilitation à diriger des recherches soutenue le 24 novembre 2006.Composition du juryHenri Béjoint (Lyon 2Franz Josef Hausmann (Erlangen-NürnbergBenoît Habert (Paris 10Pierre Rézeau (CNRSMichel Roché (Toulouse 2Danièle Van de Velde (Lille 3, UMR STL, Directrice d'habilitation.Philippe Sabot, La philosophie, entre pratiques de lecture et pratiques d'écritureHabilitation à diriger des recherches soutenue le 24 novembre 2006.Compositio...

  13. Des cartes dans la classe…

    Directory of Open Access Journals (Sweden)

    R. Gimeno

    1990-09-01

    Full Text Available La majorité des enseignants qui veulent faire des cartes — et les faire réaliser aux élèves — pour répondre aux exigences des instructions officielles, doivent surmonter leur manque de compétences en cartographie et en didactique ainsi que les difficultés propres aux logiciels de cartographie encore peu performants. Ces compétences et la réflexion qui les accompagne sont pourtant accessibles aux enfants de l’école élémentaire…

  14. Wider die Verherrlichung des Weiblichen : Kritik des Ökofeminismus

    OpenAIRE

    Attia, Iman

    1991-01-01

    Die Studie ist eine Kritik am Frauen- und Gesellschaftsbild des Ökofeminismus. Nach der Darstellung wesentlicher theoretischer Kategorien des Ökofeminismus, die sich zentrieren im Ideal der Hausarbeit als wichtigste Form von Subsistenzarbeit, stellt die Autorin zusammenfassend fest, daß der Ökofeminismus die gesellschaftlichen Unterschiede und historischen Veränderungen ignoriert, indem er den Weiblichkeitsbegriff aus der Gebärfähigkeit ableitet. Jede Ausbeutungsform wird reduziert auf biolog...

  15. Prioritization of Companion Animal Transmissible Diseases for Policy Intervention in Europe

    NARCIS (Netherlands)

    Cito, F; Rijks, J; Rantsios, A T; Cunningham, A A; Baneth, G; Guardabassi, L; Kuiken, T; Giovannini, A

    2016-01-01

    A number of papers have been published on the prioritization of transmissible diseases in farm animals and wildlife, based either on semiquantitative or truly quantitative methods, but there is no published literature on the prioritization of transmissible diseases in companion animals. In this stud

  16. Design of a Group Decision Support System Prioritizing Air Force Logistics Needs

    Science.gov (United States)

    1990-03-01

    the system and can be invoked in any order. G-4 Logistics Needs Prioritizatlon System Home Screen List LNs Attributes Assign Values Proritize ...are saved. G-29 Logistics Needs PrioritIzation System Home Screen List LNs Attributes Assign Values Proritize Communlost QUIT MAIN MAPI II ELPJNOjADJ

  17. Data-driven prioritization of chemicals for various water types using suspect screening LC-HRMS

    NARCIS (Netherlands)

    Sjerps, Rosa M.A.; Vughs, Dennis; van Leerdam, Jan A.; ter Laak, Thomas L.; van Wezel, Annemarie P.

    2016-01-01

    For the prioritization of more than 5200 anthropogenic chemicals authorized on the European market, we use a large scale liquid chromatography-high resolution mass spectrometry (LC-HRMS) suspect screening study. The prioritization is based on occurrence in 151 water samples including effluent, surfa

  18. Prioritization of Companion Animal Transmissible Diseases for Policy Intervention in Europe

    NARCIS (Netherlands)

    Cito, F; Rijks, J; Rantsios, A T; Cunningham, A A; Baneth, G; Guardabassi, L; Kuiken, T; Giovannini, A

    2016-01-01

    A number of papers have been published on the prioritization of transmissible diseases in farm animals and wildlife, based either on semiquantitative or truly quantitative methods, but there is no published literature on the prioritization of transmissible diseases in companion animals. In this stud

  19. The Interplay Between Evidence and Judgment in the IT Project Prioritization Process

    DEFF Research Database (Denmark)

    Shollo, Arisa; Constantiou, Ioanna; Kreiner, Kristian

    2015-01-01

    Strategic decisions concerning IT investments are based on a project prioritization process designed to accommodate evidence-based management and rational decision-making. Our empirical study of IT project prioritization in a financial institution shows how managers reach decisions under norms...

  20. La fabrique des extraterrestres

    OpenAIRE

    Poulain, Sébastien

    2012-01-01

    Grâce à différentes stratégies discursives et médiatiques, Radio Ici et Maintenant joue un rôle dans la fabrication de la rumeur de l’existence des extraterrestres. Cette rumeur, teintée de complot, doit servir à légitimer l’utopie messianique et millénariste de cette radio New Age qui dispose de 5 000 auditeurs au quotidien. Cette radio prophétique et thérapeutique participe donc, jusqu’à un certain degré, au renouvellement de l’espace du politico-religieux. Thanks to various media and di...

  1. Therapie des Harnwegsinfekts

    Directory of Open Access Journals (Sweden)

    Stoiser B

    2010-01-01

    Full Text Available Harnwegsinfektionen gehören zu den häufigsten entzündlichen Erkrankungen im niedergelassenen Bereich. Eine intelligente Therapiestrategie stellt damit nicht nur eine klinische Herausforderung dar, sondern ermöglicht rasche Heilung, Vermeidung von Resistenzbildungen sowie oft unnötiger, teurer diagnostischer Schritte. Der erste entscheidende Schritt ist die genaue Klassifizierung des Harnweginfektes – asymptomatische Bakteriurie bis zur komplizierten Pyelonephritis. Hier entscheiden sich bereits Aggressivität der Behandlung sowie diagnostischer Aufwand. Für die Entwicklung einer empirischen antimikrobiellen Therapie ist die Kenntnis der häufigsten Erreger sowie lokaler Resistenzmuster wichtig. Bei gezieltem Vorgehen können die meisten Harnwegsinfekte ohne erhöhten diagnostischen Aufwand therapiert werden.

  2. Communicable diseases prioritized for surveillance and epidemiological research: results of a standardized prioritization procedure in Germany, 2011.

    Directory of Open Access Journals (Sweden)

    Yanina Balabanova

    Full Text Available INTRODUCTION: To establish strategic priorities for the German national public health institute (RKI and guide the institute's mid-term strategic decisions, we prioritized infectious pathogens in accordance with their importance for national surveillance and epidemiological research. METHODS: We used the Delphi process with internal (RKI and external experts and a metric-consensus approach to score pathogens according to ten three-tiered criteria. Additional experts were invited to weight each criterion, leading to the calculation of a median weight by which each score was multiplied. We ranked the pathogens according to the total weighted score and divided them into four priority groups. RESULTS: 127 pathogens were scored. Eighty-six experts participated in the weighting; "Case fatality rate" was rated as the most important criterion. Twenty-six pathogens were ranked in the highest priority group; among those were pathogens with internationally recognised importance (e.g., Human Immunodeficiency Virus, Mycobacterium tuberculosis, Influenza virus, Hepatitis C virus, Neisseria meningitides, pathogens frequently causing large outbreaks (e.g., Campylobacter spp., and nosocomial pathogens associated with antimicrobial resistance. Other pathogens in the highest priority group included Helicobacter pylori, Respiratory Syncytial Virus, Varicella zoster virus and Hantavirus. DISCUSSION: While several pathogens from the highest priority group already have a high profile in national and international health policy documents, high scores for other pathogens (e.g., Helicobacter pylori, Respiratory syncytial virus or Hantavirus indicate a possible under-recognised importance within the current German public health framework. A process to strengthen respective surveillance systems and research has been started. The prioritization methodology has worked well; its modular structure makes it potentially useful for other settings.

  3. Evolution of Bacillus subtilis to enhanced growth at low pressure: up-regulated transcription of des-desKR, encoding the fatty acid desaturase system.

    Science.gov (United States)

    Fajardo-Cavazos, Patricia; Waters, Samantha M; Schuerger, Andrew C; George, Sheeja; Marois, James J; Nicholson, Wayne L

    2012-03-01

    The atmospheric pressure on Mars ranges from 1-10 mbar, about 1% of Earth pressure (∼1013 mbar). Low pressure is a growth-inhibitory factor for terrestrial microorganisms on Mars, and a putative low-pressure barrier for growth of Earth bacteria of ∼25 mbar has been postulated. In a previous communication, we described the isolation of a strain of Bacillus subtilis that had evolved enhanced growth ability at the near-inhibitory low pressure of 50 mbar. To explore mechanisms that enabled growth of the low-pressure-adapted strain, numerous genes differentially transcribed between the ancestor strain WN624 and low-pressure-evolved strain WN1106 at 50 mbar were identified by microarray analysis. Among these was a cluster of three candidate genes (des, desK, and desR), whose mRNA levels in WN1106 were higher than the ancestor on the microarrays. Up-regulation of these genes was confirmed by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) analysis. The des, desK, and desR genes encode the Des membrane fatty acid (FA) desaturase, the DesK sensor kinase, and the DesR response regulator, respectively, which function to maintain membrane fluidity in acute response to temperature downshift. Pressure downshift caused an up-regulation of des mRNA levels only in WN1106, but expression of a des-lacZ transcriptional fusion was unaffected, which suggests that des regulation was different in response to temperature versus pressure downshift. Competition experiments showed that inactivation of the des gene caused a slight, but statistically significant, loss of fitness of strain WN1106 at 50 mbar. Further, analysis of membrane FA composition of cells grown at 1013 versus 50 mbar revealed a decrease in the ratio of unsaturated to saturated FAs but an increase in the ratio of anteiso- to iso-FAs. The present study represents a first step toward identification of molecular mechanisms by which B. subtilis could sense and respond to the novel environmental stress

  4. PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils.

    Science.gov (United States)

    Heit, Bryan; Robbins, Stephen M; Downey, Charlene M; Guan, Zhiwen; Colarusso, Pina; Miller, B Joan; Jirik, Frank R; Kubes, Paul

    2008-07-01

    Neutrophils encounter and 'prioritize' many chemoattractants in their pursuit of bacteria. Here we tested the possibility that the phosphatase PTEN is responsible for the prioritization of chemoattractants. Neutrophils induced chemotaxis by two separate pathways, the phosphatidylinositol-3-OH kinase (PI(3)K) phosphatase and tensin homolog (PTEN) pathway, and the p38 mitogen-activated protein kinase pathway, with the p38 pathway dominating over the PI(3)K pathway. Pten(-/-) neutrophils could not prioritize chemoattractants and were 'distracted' by chemokines when moving toward bacterial chemoattractants. In opposing gradients, PTEN became distributed throughout the cell circumference, which inhibited all PI(3)K activity, thus permitting 'preferential' migration toward bacterial products via phospholipase A(2) and p38. Such prioritization was defective in Pten(-/-) neutrophils, which resulted in defective bacterial clearance in vivo. Our data identify a PTEN-dependent mechanism in neutrophils to prioritize, 'triage' and integrate responses to multiple chemotactic cues.

  5. Preventive Maintenance Prioritization by Fuzzy Logic for Seamless Hydro Power Generation

    Science.gov (United States)

    Roy, P. K.; Adhikary, P.; Mazumdar, A.

    2014-06-01

    Preventive maintenance prioritization is one of the most important criteria for the electricity generation planners to minimize the down time and production costs. Break down of equipments increases costs and plant down time results in loss of business. This work focuses on prioritizing the preventive maintenance for seamless hydro power generation considering (24 × 7) client's power demand using fuzzy logic. The main task involves prioritizing the maintenance work considering constraints of varied power demand and hydro turbine plant breakdown. Fuzzy logic is used to optimize the preventive maintenance prioritization under the main constraints. Manual fuzzy arithmetic is used to develop the model and MATLAB Fuzzy Inference System editor used to validate the same. This novel fuzzy logic approach of preventive maintenance prioritizing for hydro power generation is absent in renewable power generation and industrial engineering literatures due to its assessment complexity.

  6. Risk-based prioritization of ground water threatening point sources at catchment and regional scales

    DEFF Research Database (Denmark)

    Overheu, Niels Døssing; Tuxen, Nina; Flyvbjerg, John;

    2014-01-01

    framework has been developed to enable a systematic and transparent risk assessment and prioritization of contaminant point sources, considering the local, catchment, or regional scales (Danish EPA, 2011, 2012). The framework has been tested in several catchments in Denmark with different challenges...... and needs, and two of these are presented. Based on the lessons learned, the Danish EPA has prepared a handbook to guide the user through the steps in a risk-based prioritization (Danish EPA, 2012). It provides guidance on prioritization both in an administratively defined area such as a Danish Region......, and within the bounds of a specified ground water catchment. The handbook presents several approaches in order to prevent the prioritization from foundering because of a lack of data or an inappropriate level of complexity. The developed prioritization tools, possible graphical presentation and use...

  7. Diversité, priorité pastorale et de conservation des ligneux fourragers des terres de parcours en zone soudano-guinéenne du Bénin

    OpenAIRE

    Sèwadé, C.; Azihou, AF.; Fandohan, AB.; Houéhanou, TD.; Houinato, M.

    2016-01-01

    Diversity, pastoral and conservation priorities of fodder trees in the Sudano-Guinean pasture lands of Benin. Description of the subject. Fodder trees are important for livestock survival in dryland Africa. In view of the pressure faced by these trees, and their consequent rarity noted in rangelands, a study was conducted in the Sudano-Guinean transition zone of Benin at the level of the local population surrounding the protected forests of Monts Kouffé, Wari-Maro and Ouémé Supérieur. Objecti...

  8. LA TRADUCTION DES PREPOSITIONS

    Directory of Open Access Journals (Sweden)

    Samira MOUTAKIL

    2013-05-01

    Full Text Available L’idée de cet article nous est venue d’un cours qu’on assure pour les futurs guides touristiques en Jordanie. En traduisant des textes - français-arabe ou arabe-français, les étudiants se heurtent à certains problèmes pour rendre le texte vers la langue cible et qui soit convenable syntaxiquement et sémantiquement. On a remarqué donc que la traduction des prépositions vers l’une ou l’autre langue présente un dilemme pour les apprenants. On a décidé de composer un corpus de phrases contenant les propositions en français, « à » avec toutes ses formes, « dans et sur » et de l'arabe "على", "في" . Dans un premier temps, on a constitué le corpus avec 25 phrases dans les deux langues et on les a soumises aux étudiants, la liste en français aux étudiants du niveau A2 et la liste ne arabe aux étudiants du niveau A1. Par la suite, on a dégagé ce qui ressort de leurs traductions ce qui nous a permis de faire une analyse sémantico-syntaxique assez détaillée. En conclusion de cet article, on présente les résultats de cette expérience très intéressante.

  9. Marais Des Cygnes Wildlife Area

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This brochure is for the Marais des Cygnes Wildlife Area, managed by Kansas Department of Wildlife, Parks and Tourism, and located in the floodplain of the Marais...

  10. Digitalisierung des Kulturellen Erbes (Europas)

    NARCIS (Netherlands)

    Gruber, Marion

    2011-01-01

    Gruber, M. R. (2011, 13 December). Digitalisierung des Kulturellen Erbes (Europas). Guest lecture at the IPMZ - Institute of Mass Communication and Media Research, Devision Media Change & Innovation, University of Zurich, Switzerland.

  11. Research priorities in mobile learning: An international Delphi study / Les priorités de recherche en matière d'apprentissage mobile: Une étude de Delphes internationale

    Directory of Open Access Journals (Sweden)

    Yu-Chang Hsu

    2014-05-01

    Full Text Available Along with advancing mobile technologies and proliferating mobile devices and applications, mobile learning research has gained great momentum in recent years. While there have been review articles summarizing past research, studies identifying mobile learning research priorities based on experts’ latest insights have been lacking. This study employed the Delphi method to obtain a consensus from experts about areas that are most in need of research in mobile learning. An international expert panel participated in a three-round Delphi process involving two cycles of online questionnaires and feedback reports. Participants responded to the question, “What should be the research priorities for the field of mobile learning over the next 5 years?” Ten research categories were identified and ranked in order of priority: 1 teaching and learning strategies; 2 affordances; 3 theory; 4 settings of learning; 5 evaluation/assessment; 6 learners; 7 mobile technologies and interface design; 8 context awareness and augmented reality; 9 infrastructure and management; and 10 country and digital divide. This study also reported expert-generated research statements for each research category and the importance of these research statements rated by the experts. Selected research papers were summarized to help contextualize the discussions of research categories and statements. Avec l'avancement des technologies mobiles et la prolifération des appareils mobiles et des applications, la recherche consacrée à l'apprentissage mobile a récemment pris de l’ampleur. Si des articles ont résumé les recherches antérieures, les études s’appuyant sur les dernières connaissances d'experts pour identifier les priorités de recherche sur l'apprentissage mobile font défaut. La présente étude a utilisé la méthode de Delphes pour obtenir un consensus des experts sur les domaines nécessitant le plus des recherches sur l'apprentissage mobile. Un groupe

  12. A New Way to Confirm Planet Candidates

    Science.gov (United States)

    Kohler, Susanna

    2016-05-01

    What was the big deal behind the Kepler news conference yesterday? Its not just that the number of confirmed planets found by Kepler has more than doubled (though thats certainly exciting news!). Whats especially interesting is the way in which these new planets were confirmed.Number of planet discoveries by year since 1995, including previous non-Kepler discoveries (blue), previous Kepler discoveries (light blue) and the newly validated Kepler planets (orange). [NASA Ames/W. Stenzel; Princeton University/T. Morton]No Need for Follow-UpBefore Kepler, the way we confirmed planet candidates was with follow-up observations. The candidate could be validated either by directly imaging (which is rare) or obtaining a large number radial-velocity measurements of the wobble of the planets host star due to the planets orbit. But once Kepler started producing planet candidates, these approaches to validation became less feasible. A lot of Kepler candidates are small and orbit faint stars, making follow-up observations difficult or impossible.This problem is what inspired the development of whats known as probabilistic validation, an analysis technique that involves assessing the likelihood that the candidates signal is caused by various false-positive scenarios. Using this technique allows astronomers to estimate the likelihood of a candidate signal being a true planet detection; if that likelihood is high enough, the planet candidate can be confirmed without the need for follow-up observations.A breakdown of the catalog of Kepler Objects of Interest. Just over half had previously been identified as false positives or confirmed as candidates. 1284 are newly validated, and another 455 have FPP of1090%. [Morton et al. 2016]Probabilistic validation has been used in the past to confirm individual planet candidates in Kepler data, but now Timothy Morton (Princeton University) and collaborators have taken this to a new level: they developed the first code thats designed to do fully

  13. Confirmed and Potential Sources of Legionella Reviewed.

    Science.gov (United States)

    van Heijnsbergen, Eri; Schalk, Johanna A C; Euser, Sjoerd M; Brandsema, Petra S; den Boer, Jeroen W; de Roda Husman, Ana Maria

    2015-04-21

    Legionella bacteria are ubiquitous in natural matrices and man-made systems. However, it is not always clear if these reservoirs can act as source of infection resulting in cases of Legionnaires' disease. This review provides an overview of reservoirs of Legionella reported in the literature, other than drinking water distribution systems. Levels of evidence were developed to discriminate between potential and confirmed sources of Legionella. A total of 17 systems and matrices could be classified as confirmed sources of Legionella. Many other man-made systems or natural matrices were not classified as a confirmed source, since either no patients were linked to these reservoirs or the supporting evidence was weak. However, these systems or matrices could play an important role in the transmission of infectious Legionella bacteria; they might not yet be considered in source investigations, resulting in an underestimation of their importance. To optimize source investigations it is important to have knowledge about all the (potential) sources of Legionella. Further research is needed to unravel what the contribution is of each confirmed source, and possibly also potential sources, to the LD disease burden.

  14. The composition of Io - a late confirmation

    CERN Document Server

    Celebonovic, V

    1996-01-01

    Nine years ago,working within the framework of theoretical dense matter physics,the present author has determined the chemical composition of the Galileian satellites of Jupiter.A few months ago,in the flyby of the GA- LILEO spaceprobe,some of the theoretical predictions were confirmed.

  15. Business-oriented prioritization: A novel graphical technique

    Energy Technology Data Exchange (ETDEWEB)

    Pascual, R. [Centro de Mineria, Pontificia Universidad Catolica de Chile, Av. Vicuna Mackenna 4860, Santiago (Chile)], E-mail: rpascual@ing.puc.cl; Del Castillo, G. [Department of Mechanical Engineering, Universidad de Chile, Casilla 2777, Santiago (Chile); Louit, D. [Komatsu Chile, Av. Americo Vespucio 0631, Quilicura, Santiago (Chile); Centro de Mineria, Pontificia Universidad Catolica de Chile, Av. Vicuna Mackenna 4860, Santiago (Chile); Knights, P. [Division of Mining Engineering, Faculty of Engineering, Architecture and Information Technology, The University of Queensland, St. Lucia, Brisbane, 4072 (Australia)

    2009-08-15

    Traditionally, Pareto analysis has been used to select the most critical components and failure modes of a system. A clear disadvantage of this technique is that it requires preselecting a single criterion to establish priorities. More recently, a graphical log-scatter diagram technique has been proposed. It considers three key performance indicators simultaneously: reliability (MTBF), maintainability (MTTR), and unavailability (D). This technique considers only times and does not include economical effects explicitly. This article extends both techniques to explicitly consider both direct and indirect costs to prioritize from the point of view of an asset manager or from a maintenance decision-maker, as required. Due to the economic-based approach of this article, cost discounting is also considered inside financial costs such as-but not limited to-reliability-related investments. Also, the results are displayed on simple and accessible graphs which make them particularly useful for conveying results to non-technical managers. The methodology is illustrated by analyzing a shovel from the copper mine industry, and it clearly shows how the proposed technique facilitates business oriented decisions and how they should change under different market conditions.

  16. Target allocation and prioritized motion planning for MIRADAS probe arms

    Science.gov (United States)

    Sabater, Josep; Riera-Ledesma, Jorge; Torres, Santiago; Garzón, Francisco; Torra, Jordi; Gómez, José M.

    2016-07-01

    The Mid-resolution InfRAreD Astronomical Spectrograph (MIRADAS) is a near-infrared multi-object echelle spectrograph for the 10.4-meter Gran Telescopio Canarias. The instrument has 12 pickoff mirror optics on cryogenic probe arms, enabling it to concurrently observe up to 12 user-defined objects located in its field-of-view. In this paper, a method to compute collision-free trajectories for the arms of MIRADAS is presented. We propose a sequential approach that has two stages: target to arm assignment and motion planning. For the former, we present a model based on linear programming that allocates targets according to their associated priorities. The model is constrained by two matrices specifying the targets' reachability and the incompatibilities among each pair of feasible target-arm pairs. This model has been implemented and experiments show that it is able to determine assignments in less than a second. Regarding the second step, we present a prioritized approach which uses sampled-based roadmaps containing a variety of paths. The motions along a given path are coordinated with the help of a depth-first search algorithm. Paths are sequentially explored according to how promising they are and those not leading to a solution are skipped. This motion planning approach has been implemented considering real probe arm geometries and joint velocities. Experimental results show that the method achieves good performance in scenarios presenting two different types of conflicts.

  17. An integrative computational approach for prioritization of genomic variants.

    Directory of Open Access Journals (Sweden)

    Inna Dubchak

    Full Text Available An essential step in the discovery of molecular mechanisms contributing to disease phenotypes and efficient experimental planning is the development of weighted hypotheses that estimate the functional effects of sequence variants discovered by high-throughput genomics. With the increasing specialization of the bioinformatics resources, creating analytical workflows that seamlessly integrate data and bioinformatics tools developed by multiple groups becomes inevitable. Here we present a case study of a use of the distributed analytical environment integrating four complementary specialized resources, namely the Lynx platform, VISTA RViewer, the Developmental Brain Disorders Database (DBDB, and the RaptorX server, for the identification of high-confidence candidate genes contributing to pathogenesis of spina bifida. The analysis resulted in prediction and validation of deleterious mutations in the SLC19A placental transporter in mothers of the affected children that causes narrowing of the outlet channel and therefore leads to the reduced folate permeation rate. The described approach also enabled correct identification of several genes, previously shown to contribute to pathogenesis of spina bifida, and suggestion of additional genes for experimental validations. The study demonstrates that the seamless integration of bioinformatics resources enables fast and efficient prioritization and characterization of genomic factors and molecular networks contributing to the phenotypes of interest.

  18. Component Fragility Research Program: Phase 1 component prioritization

    Energy Technology Data Exchange (ETDEWEB)

    Holman, G.S.; Chou, C.K.

    1987-06-01

    Current probabilistic risk assessment (PRA) methods for nuclear power plants utilize seismic ''fragilities'' - probabilities of failure conditioned on the severity of seismic input motion - that are based largely on limited test data and on engineering judgment. Under the NRC Component Fragility Research Program (CFRP), the Lawrence Livermore National Laboratory (LLNL) has developed and demonstrated procedures for using test data to derive probabilistic fragility descriptions for mechanical and electrical components. As part of its CFRP activities, LLNL systematically identified and categorized components influencing plant safety in order to identify ''candidate'' components for future NRC testing. Plant systems relevant to safety were first identified; within each system components were then ranked according to their importance to overall system function and their anticipated seismic capacity. Highest priority for future testing was assigned to those ''very important'' components having ''low'' seismic capacity. This report describes the LLNL prioritization effort, which also included application of ''high-level'' qualification data as an alternate means of developing probabilistic fragility descriptions for PRA applications.

  19. Prioritizing research needs: insights from a healthcare organization in Iran

    Directory of Open Access Journals (Sweden)

    Mohammadkarim Bahadori 1*, Ehsan Teimourzadeh 1, Ali Farzaneh 1, Mostafa Nejati 2

    2011-09-01

    Full Text Available Objectives: The goal of this study was to identify the priorityof research needs in a healthcare organization in Iran, based onidentification of the problems faced by patients, as the mainrecipients of healthcare services.Method: A cross -sectional descriptive study was planned toachieve the objectives of study. The service recipients sampleconsisted of 400 patients. Given the necessity to gain in-depthinsights of the subject matter, a qualitative research design waschosen. A number of 50 interviews were conducted withindividuals from among 400 patients. The data was analyzedusing ATLAS.ti softwarePrioritizing of the topics was doneusing Analytical Hierarchy Process (AHP method and theExpert Choice software.Results: Based on the issues extracted from the interviews anddiscourses, 13 research topics were proposed by experts.Among these, the topics “designing the model of premium andcomplementary franchise payment, proportional to theincome, access and enjoyment”, “designing the dental servicespackage with specific premium in three basic, complementaryand optional levels” and “Presenting the model of diseaseprevention in healthcare organizations” acquired the highestpriority ranked 1 to 3 and earning the scores of 0.63, 0.61 and0.41, respectively.Conclusion: Because resources are limited and needs areunlimited, in order to avoid wasting research resources inhealthcare organizations, allocating the resources must bebased on the extracted priorities; and this is vital to fulfill theorganizational objectives.

  20. Timed Test Case Generation Using Labeled Prioritized Time Petri Nets

    Directory of Open Access Journals (Sweden)

    Noureddine Adjir

    2012-03-01

    Full Text Available Model-based testing of software and hardware systems uses behavioral and formal models of the systems. The paper presents a technique for model-based black-box conformance testing of real-time systems using Labeled Prioritized Time Petri Nets (LPrTPN. The Timed Input/Output Conformance (tioco relation, which takes environment assumptions into account, serves as reference to decide of implementation correctness. Test suites are derived automatically from a LPrTPN made up of two concurrent sub-nets that respectively specify the system under test and its environment. The result is optimal in the sense that test cases have the shortest possible accumulated time to be executed. Test cases selection combines test purposes and structural coverage criteria associated with the model. A test purpose or a coverage criterion is specified in a SE-LTL formula. The TIme Petri Net Analyzer TINA has been extended to support concurrent composed subnets. Automatic generation of time-optimal test suites with the Tina toolbox combines the model checker selt and the path analyzer plan. selt outputs a sequence that satisfies the logic formula. plan computes the fastest execution of this sequence which will be transformed in a test cases suite.

  1. An Integrative Computational Approach for Prioritization of Genomic Variants

    Science.gov (United States)

    Wang, Sheng; Meyden, Cem; Sulakhe, Dinanath; Poliakov, Alexander; Börnigen, Daniela; Xie, Bingqing; Taylor, Andrew; Ma, Jianzhu; Paciorkowski, Alex R.; Mirzaa, Ghayda M.; Dave, Paul; Agam, Gady; Xu, Jinbo; Al-Gazali, Lihadh; Mason, Christopher E.; Ross, M. Elizabeth; Maltsev, Natalia; Gilliam, T. Conrad

    2014-01-01

    An essential step in the discovery of molecular mechanisms contributing to disease phenotypes and efficient experimental planning is the development of weighted hypotheses that estimate the functional effects of sequence variants discovered by high-throughput genomics. With the increasing specialization of the bioinformatics resources, creating analytical workflows that seamlessly integrate data and bioinformatics tools developed by multiple groups becomes inevitable. Here we present a case study of a use of the distributed analytical environment integrating four complementary specialized resources, namely the Lynx platform, VISTA RViewer, the Developmental Brain Disorders Database (DBDB), and the RaptorX server, for the identification of high-confidence candidate genes contributing to pathogenesis of spina bifida. The analysis resulted in prediction and validation of deleterious mutations in the SLC19A placental transporter in mothers of the affected children that causes narrowing of the outlet channel and therefore leads to the reduced folate permeation rate. The described approach also enabled correct identification of several genes, previously shown to contribute to pathogenesis of spina bifida, and suggestion of additional genes for experimental validations. The study demonstrates that the seamless integration of bioinformatics resources enables fast and efficient prioritization and characterization of genomic factors and molecular networks contributing to the phenotypes of interest. PMID:25506935

  2. Prioritizing Test Cases for Memory Leaks in Android Applications

    Institute of Scientific and Technical Information of China (English)

    Ju Qian; Di Zhou

    2016-01-01

    Mobile applications usually can only access limited amount of memory. Improper use of the memory can cause memory leaks, which may lead to performance slowdowns or even cause applications to be unexpectedly killed. Although a large body of research has been devoted into the memory leak diagnosing techniques after leaks have been discovered, it is still challenging to find out the memory leak phenomena at first. Testing is the most widely used technique for failure discovery. However, traditional testing techniques are not directed for the discovery of memory leaks. They may spend lots of time on testing unlikely leaking executions and therefore can be inefficient. To address the problem, we propose a novel approach to prioritize test cases according to their likelihood to cause memory leaks in a given test suite. It firstly builds a prediction model to determine whether each test can potentially lead to memory leaks based on machine learning on selected code features. Then, for each input test case, we partly run it to get its code features and predict its likelihood to cause leaks. The most suspicious test cases will be suggested to run at first in order to reveal memory leak faults as soon as possible. Experimental evaluation on several Android applications shows that our approach is effective.

  3. Integrating conservation costs into sea level rise adaptive conservation prioritization

    Directory of Open Access Journals (Sweden)

    Mingjian Zhu

    2015-07-01

    Full Text Available Biodiversity conservation requires strategic investment as resources for conservation are often limited. As sea level rises, it is important and necessary to consider both sea level rise and costs in conservation decision making. In this study, we consider costs of conservation in an integrated modeling process that incorporates a geomorphological model (SLAMM, species habitat models, and conservation prioritization (Zonation to identify conservation priorities in the face of landscape dynamics due to sea level rise in the Matanzas River basin of northeast Florida. Compared to conservation priorities that do not consider land costs in the analysis process, conservation priorities that consider costs in the planning process change significantly. The comparison demonstrates that some areas with high conservation values might be identified as lower priorities when integrating economic costs in the planning process and some areas with low conservation values might be identified as high priorities when considering costs in the planning process. This research could help coastal resources managers make informed decisions about where and how to allocate conservation resources more wisely to facilitate biodiversity adaptation to sea level rise.

  4. Prioritization: A Means of Achieving Positive Rural Development In Nigeria.

    Directory of Open Access Journals (Sweden)

    Amadi

    2016-07-01

    Full Text Available Rural development occupies a priority place in agenda of Nigeria’s national development. However, the gap between scarce and stingy allocation of resources by Governments and rural people’s needs calls for prioritization in the areas of investment with regards to rural development. This paper examined the priority areas for rural development in Nigeria. Data on the needs of rural dwellers were randomly collected in 2006, 2008 and 2010 respectively. The rural dwellers were interviewed in each of the years using questionnaire and oral discussions. The questionnaire centered on rural dwellers needs among many alternatives such as Irrigation Facility, Roads, Markets, Portable Water Supply, Clinics/Hospitals, Electricity, Loan, Schools/Education and farm inputs. Analysis of variance, (ANOVA using the general linear models procedure was used in data analysis. Results show that majority of rural farmers’ needs are in order of preference Potable Water Supply, Roads, Farm Inputs, Loan and Schools/Education. The implication is that future rural development projects and Programs if directed towards these areas will help to accelerate the improvement of rural dwellers welfare and help to reduce the number of rural to urban migrating, resulting in rural stability and integrated rural development.

  5. Prioritized Multihypothesis Tracking by a Robot with Limited Sensing

    Directory of Open Access Journals (Sweden)

    2009-03-01

    Full Text Available To act intelligently in dynamic environments, mobile robots must estimate object positions using information obtained from a variety of sources. We formally describe the problem of estimating the state of objects where a robot can only task its sensors to view one object at a time. We contribute an object tracking method that generates and maintains multiple hypotheses consisting of probabilistic state estimates that are generated by the individual information sources. These different hypotheses can be generated by the robot's own prediction model and by communicating robot team members. The multiple hypotheses are often spatially disjoint and cannot simultaneously be verified by the robot's limited sensors. Instead, the robot must decide towards which hypothesis its sensors should be tasked by evaluating each hypothesis on its likelihood of containing the object. Our contributed algorithm prioritizes the different hypotheses, according to rankings set by the expected uncertainty in the object's motion model, as well as the uncertainties in the sources of information used to track their positions. We describe the algorithm in detail and show extensive empirical results in simulation as well as experiments on actual robots that demonstrate the effectiveness of our approach.

  6. Risk and information evaluation of prioritized genes for complex traits: application to bipolar disorder.

    Science.gov (United States)

    Kao, Chung-Feng; Chuang, Li-Chung; Kuo, Po-Hsiu

    2014-10-01

    Many susceptibility genes for complex traits were identified without conclusive findings. There is a strong need to integrate rapidly accumulated genomic data from multi-dimensional platforms, and to conduct risk evaluation for potential therapeutic and diagnostic usages. We set up an algorithm to computationally search for optimal weight-vector for various data sources, while minimized potential noises. Through gene-prioritization framework, combined scores for the resulting prioritized gene-set were calculated using a genome-wide association (GWA) dataset, following with evaluation using weighted genetic risk score and risk-attributed information using an independent GWA dataset. The significance of association of GWA data was corrected for gene length. Enriched functional pathways were identified for the prioritized gene-set using the Gene Ontology analysis. We illustrated our framework with bipolar disorder. 233 prioritized genes were identified from 10,830 candidates that curated from six platforms. The prioritized genes were significantly enriched (P(adjusted) evaluation demonstrated higher weighted genetic risk score in bipolar patients than controls (P-values ranged from 0.002 to 3.8 × 10(-6)). Substantial risk-information (71%) was extracted from prioritized genes for bipolar illness than other candidate-gene sets. Our evidence-based prioritized gene-set provides opportunity to explore the complex network and to conduct follow-up basic and clinical studies for complex traits.

  7. Novel Methods for Prioritizing "Close-In" Analogs from Structure-Activity Relationship Matrices.

    Science.gov (United States)

    Zhang, Liying; Johnson, Kjell; Starr, Jeremy; Milbank, Jared; Kuhn, Andrew M; Poss, Christopher; Stanton, Robert V; Shanmugasundaram, Veerabahu

    2017-07-24

    Here we describe the development of novel methods for compound evaluation and prioritization based on the structure-activity relationship matrix (SARM) framework. The SARM data structure allows automatic and exhaustive extraction of SAR patterns from data sets and their organization into a chemically intuitive scaffold/functional-group format. While SARMs have been used in the retrospective analysis of SAR discontinuity and identifying underexplored regions of chemistry space, there have been only a few attempts to apply SARMs prospectively in the prioritization of "close-in" analogs. In this work, three new ways of prioritizing virtual compounds based on SARMs are described: (1) matrix pattern-based prioritization, (2) similarity weighted, matrix pattern-based prioritization, and (3) analysis of variance based prioritization (ANV). All of these methods yielded high predictive power for six benchmark data sets (prediction accuracy R(2) range from 0.63 to 0.82), yielding confidence in their application to new design ideas. In particular, the ANV method outperformed the previously reported SARM based method for five out of the six data sets tested. The impact of various SARM parameters were investigated and the reasons why SARM-based compound prioritization methods provide higher predictive power are discussed.

  8. Sub-watershed prioritization based on sediment yield using game theory

    Science.gov (United States)

    Adhami, Maryam; Sadeghi, Seyed Hamidreza

    2016-10-01

    The proper placement of soil and water conservation measures cannot be designated due to lack of appropriate technical prioritization of different areas of a watershed. Therefore, quantifying soil erosion hazard and spatial prioritization of sub-watersheds would aid in better watershed management planning. Although, many approaches have been applied to prioritize sub-watersheds, but still the efficient techniques like game theory have not been practically applied to prioritize sub-watersheds. The present study therefore has used the game theory to prioritize sub-watersheds in Gorganroud and Qareh Sou watersheds in Golestan Province, northern Iran. Towards this goal, 38 independent factors were classified in seven components using Principal Component Analysis (PCA) method with one representative variable in each component. The Condorcet method used for prioritization of effective variables indicated that the percent of forestry lands (52 scores) and discharge with 10 years of return period (32 scores) were respectively the most and the least effective variables on sediment yield. The Fallback bargaining and the Borda Scoring algorithms were also selected to prioritize study sub-watersheds based on weighted grades of total score for each variable. Accordingly, the aforesaid algorithms classified sub-watersheds in three categories. Comparison of results similarly introduced Galikesh, Qazaqli, Gonbad, Siyah Ab and Tamar as first ranked sub-watersheds with the worth condition, Tangrah and Naharkhoran as second priority and eventually Pole Ordougah as sub-watershed with the lowest priority.

  9. An Approach for Integrating the Prioritization of Functional and Nonfunctional Requirements

    Directory of Open Access Journals (Sweden)

    Mohammad Dabbagh

    2014-01-01

    Full Text Available Due to the budgetary deadlines and time to market constraints, it is essential to prioritize software requirements. The outcome of requirements prioritization is an ordering of requirements which need to be considered first during the software development process. To achieve a high quality software system, both functional and nonfunctional requirements must be taken into consideration during the prioritization process. Although several requirements prioritization methods have been proposed so far, no particular method or approach is presented to consider both functional and nonfunctional requirements during the prioritization stage. In this paper, we propose an approach which aims to integrate the process of prioritizing functional and nonfunctional requirements. The outcome of applying the proposed approach produces two separate prioritized lists of functional and non-functional requirements. The effectiveness of the proposed approach has been evaluated through an empirical experiment aimed at comparing the approach with the two state-of-the-art-based approaches, analytic hierarchy process (AHP and hybrid assessment method (HAM. Results show that our proposed approach outperforms AHP and HAM in terms of actual time-consumption while preserving the quality of the results obtained by our proposed approach at a high level of agreement in comparison with the results produced by the other two approaches.

  10. Confirmation via Analogue Simulation: A Bayesian Analysis

    CERN Document Server

    Dardashti, Radin; Thebault, Karim P Y; Winsberg, Eric

    2016-01-01

    Analogue simulation is a novel mode of scientific inference found increasingly within modern physics, and yet all but neglected in the philosophical literature. Experiments conducted upon a table-top 'source system' are taken to provide insight into features of an inaccessible 'target system', based upon a syntactic isomorphism between the relevant modelling frameworks. An important example is the use of acoustic 'dumb hole' systems to simulate gravitational black holes. In a recent paper it was argued that there exists circumstances in which confirmation via analogue simulation can obtain; in particular when the robustness of the isomorphism is established via universality arguments. The current paper supports these claims via an analysis in terms of Bayesian confirmation theory.

  11. Terre des hommes

    CERN Multimedia

    Staff Association

    2012-01-01

    Transformez votre téléphone portable en geste de solidarité ! Collecte du 12 au 23 novembre 2012   Faites un geste simple et utile en déposant vos téléphones portables inutilisés dans les urnes installées dans les trois restaurants du CERN. En Suisse, une personne change tous les 12 à 18 mois de téléphone portable. La plupart de nos vieux appareils sont simplement laissés à l’abandon avec comme seule fonction de parer une éventuelle panne à venir. On  estime ainsi que 8 millions de portables sont inutilisés, alors qu'entre 30 et 50% peuvent être réutilisés. L'action Solidarcomm leur offre une deuxième vie ! Terre des Hommes Suisse, dans le cadre de la campagne Solidarcomm, collecte et valorise vos téléphones inutilis&...

  12. Onlinespieler abseits des Mainstreams

    Directory of Open Access Journals (Sweden)

    Harald Baumgartlinger

    2012-12-01

    Full Text Available MMO(RPGs „Massively Multiplayer Online (Role-Playing Games“ nehmen einen Sonderstatus unter den Onlinespielen ein, welcher durch den wachsenden wirtschaftlichen Erfolg, insbesondere durch den „breakthrough hit“ (Duchenaut et al. 2006: 407 World of Warcraft (WoW, auch an Bedeutung für die Medien- und Kommunikationswissenschaft gewinnt (vgl. Inderst 2009: 15; vgl. Seifert/Jöckel 2008: 297. Der Primus des Genres, WoW, repräsentiert gemeinsam mit einigen nahezu identen Titeln insgesamt 85 Prozent der gespielten MMOGs (vgl. Williams et al. 2008: 999. Daher befasst sich auch die Mehrheit der vorliegenden Studien mit eben diesen Spielen. Neue Formen von MMO(Gs können jedoch zu ebenso neuartigen Spielerfahrungen führen und damit unterschiedliche Nutzungsmotive befriedigen (vgl. Seifert/Jöckel 2008: 309 und folglich zu einem gänzlich anderen Spielerleben führen. Während im Mainstream die kooperativen Spielerbeziehungen überwiegen, dominiert in Darkfall Online der soziale Wettbewerb. Der von Williams et al. 2008 verwendete Fragebogen diente als Rohling für die Kreation eines für die speziellen Anforderungen adaptierten Erhebungstools zur Erforschung der Spielertypologie und der Motive der Darkfall-Online-SpielerInnen. Die in der Onlinebefragung (N = 506 gesammelten Daten belegen, dass sich sowohl die Spielerdemographie, als auch die Motive der Spieler von den Mainstream MMOs unterscheiden. Zudem konnten realweltliche Eigenschaften der Spieler als signifikante Einflussfaktoren für die Spielzuwendung identifiziert werden.

  13. Peste des petits ruminants.

    Science.gov (United States)

    Parida, S; Muniraju, M; Mahapatra, M; Muthuchelvan, D; Buczkowski, H; Banyard, A C

    2015-12-14

    Peste des petits ruminants virus causes a highly infectious disease of small ruminants that is endemic across Africa, the Middle East and large regions of Asia. The virus is considered to be a major obstacle to the development of sustainable agriculture across the developing world and has recently been targeted by the World Organisation for Animal Health (OIE) and the Food and Agriculture Organisation (FAO) for eradication with the aim of global elimination of the disease by 2030. Fundamentally, the vaccines required to successfully achieve this goal are currently available, but the availability of novel vaccine preparations to also fulfill the requisite for differentiation between infected and vaccinated animals (DIVA) may reduce the time taken and the financial costs of serological surveillance in the later stages of any eradication campaign. Here, we overview what is currently known about the virus, with reference to its origin, updated global circulation, molecular evolution, diagnostic tools and vaccines currently available to combat the disease. Further, we comment on recent developments in our knowledge of various recombinant vaccines and on the potential for the development of novel multivalent vaccines for small ruminants. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

  14. Multidisciplinary and evidence-based method for prioritizing diseases of food-producing animals and zoonoses.

    Science.gov (United States)

    Humblet, Marie-France; Vandeputte, Sébastien; Albert, Adelin; Gosset, Christiane; Kirschvink, Nathalie; Haubruge, Eric; Fecher-Bourgeois, Fabienne; Pastoret, Paul-Pierre; Saegerman, Claude

    2012-04-01

    To prioritize 100 animal diseases and zoonoses in Europe, we used a multicriteria decision-making procedure based on opinions of experts and evidence-based data. Forty international experts performed intracategory and intercategory weighting of 57 prioritization criteria. Two methods (deterministic with mean of each weight and probabilistic with distribution functions of weights by using Monte Carlo simulation) were used to calculate a score for each disease. Consecutive ranking was established. Few differences were observed between each method. Compared with previous prioritization methods, our procedure is evidence based, includes a range of fields and criteria while considering uncertainty, and will be useful for analyzing diseases that affect public health.

  15. Diffuse panbronchiolitis with histopathological confirmation among Chinese

    Institute of Scientific and Technical Information of China (English)

    谢广顺; 李龙芸; 刘鸿瑞; 张伟宏; 朱元珏

    2004-01-01

    Background Diffuse panbronchiolitis (DPB) was originally and is still primarily reported in Japan, rarely in other countries. As macrolide therapy is effective for this disease with once dismal prognosis, familiarity with its clinical features is urgently needed, especially for clinicians outside Japan. The objectives of this study were to investigate the clinical features of DPB in a Chinese population and propose diagnostic procedures that will lead to increased awareness of this treatable disease among clinicians, ultimately allowing for more rapid diagnosis. Methods After a literature review, the clinical features of DPB were histopathologically confirmed in a series of 9 cases either by open lung biopsy or video-assisted thoracic surgical biopsy, resulting in the largest series of confirmed DPB cases in a non-Japanese population. Here, the cases are retrospectively described and diagnostic procedures are discussed.Conclusions Although its clinical features may vary with disease course and ethnic populations, most cases of DPB can be diagnosed or suggested according to clinical diagnostic criteria. However, underdiagnosis as a result of unfamiliarity with its clinical features and diagnostic criteria prevails. If difficulty in diagnosis arises, the diagnosis should be based on clinicopathological features and the exclusion of other diseases. Few cases can be confirmed by transbronchial biopsies; in these cases, either an open-lung biopsy or a video-assisted thoracic surgical lung biopsy should be recommended.

  16. CCC/WPA study : Des Lacs NWR

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Summary of the Civilian Conservation Corps (CCC) camp at Des Lacs National Wildlife Refuge from July 1935-May 1942 to carry on restoration and development of Des...

  17. Current algebra; Algebre des courants

    Energy Technology Data Exchange (ETDEWEB)

    Jacob, M. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-07-01

    The first three chapters of these lecture notes are devoted to generalities concerning current algebra. The weak currents are defined, and their main properties given (V-A hypothesis, conserved vector current, selection rules, partially conserved axial current,...). The SU (3) x SU (3) algebra of Gell-Mann is introduced, and the general properties of the non-leptonic weak Hamiltonian are discussed. Chapters 4 to 9 are devoted to some important applications of the algebra. First one proves the Adler- Weisberger formula, in two different ways, by either the infinite momentum frame, or the near-by singularities method. In the others chapters, the latter method is the only one used. The following topics are successively dealt with: semi leptonic decays of K mesons and hyperons, Kroll- Ruderman theorem, non leptonic decays of K mesons and hyperons ( {delta}I = 1/2 rule), low energy theorems concerning processes with emission (or absorption) of a pion or a photon, super-convergence sum rules, and finally, neutrino reactions. (author) [French] La premiere partie de ce cours (trois premiers chapitres), traite des generalites concernant l'algebre de courants. Apres une definition rapide des courants faibles et un rappel de leurs proprietes (hypothese V-A, conservation du courant vecteur, regles de selection, courant axial partiellement conserve,...), l'on introduit l'algebre de Gell-Mann SU (3) x SU (3), et discute les proprietes generales de l'Hamiltonien faible non leptonique. Les chapitres IV a IX sont consacres a des applications importantes de l'algebre des courants. En premier lieu l'on demontre la formule de Adler et Weisberger, par deux methodes differentes, celle dite du repere de moment infini et celle des singularites proches. Cette derniere est seule utilisee dans la suite. Puis, l'on traite successivement les problemes suivants: desintegrations semi-leptoniques des mesons K et des hyperons, theoreme de Kroll

  18. La théorie des industries culturelles (et informationnelles, composante des SIC

    Directory of Open Access Journals (Sweden)

    Bernard Miège

    2012-09-01

    Full Text Available Inaugurer le Cahier central de la Revue des SIC est certes une forme de reconnaissance, mais cela comporte des obligations, au premier rang desquelles la nécessité d’intéresser des lecteurs a priori pas immédiatement concernés par la thématique.Si la théorie des industries culturelles est devenue progressivement une approche marquante des SIC, en France, en Europe et plus largement encore (avec des dénominations variables et des modalités spécifiques, ce n’est en effet ni en le proclamant ha...

  19. Neologismen des Lettischen anhand des schriftstellerischen Werkes von Zigmunds Skujins

    OpenAIRE

    Javojss, Skaidrite

    2010-01-01

    Untersuchung: Aus acht Werken des zeitgenössischen Schriftstellers Zigmunds Skujins wurden 500 lettische Wörter untersucht, die in den drei umfangreichsten lettischen Wörterbüchern nicht verzeichnet und somit möglicherweise Neologismen des Autors sind. Analysiert werden die Wortarten, die Komposita, die Herkunft der assimilierten Lehnwörter, orthographische und andere Varianten bereits lexikalisierter Wörter, die Arten der Diminutivbildung und der Präfigierung. Außerdem werden Aussagen über d...

  20. Gene prioritization and clustering by multi-view text mining.

    Science.gov (United States)

    Yu, Shi; Tranchevent, Leon-Charles; De Moor, Bart; Moreau, Yves

    2010-01-14

    Text mining has become a useful tool for biologists trying to understand the genetics of diseases. In particular, it can help identify the most interesting candidate genes for a disease for further experimental analysis. Many text mining approaches have been introduced, but the effect of disease-gene identification varies in different text mining models. Thus, the idea of incorporating more text mining models may be beneficial to obtain more refined and accurate knowledge. However, how to effectively combine these models still remains a challenging question in machine learning. In particular, it is a non-trivial issue to guarantee that the integrated model performs better than the best individual model. We present a multi-view approach to retrieve biomedical knowledge using different controlled vocabularies. These controlled vocabularies are selected on the basis of nine well-known bio-ontologies and are applied to index the vast amounts of gene-based free-text information available in the MEDLINE repository. The text mining result specified by a vocabulary is considered as a view and the obtained multiple views are integrated by multi-source learning algorithms. We investigate the effect of integration in two fundamental computational disease gene identification tasks: gene prioritization and gene clustering. The performance of the proposed approach is systematically evaluated and compared on real benchmark data sets. In both tasks, the multi-view approach demonstrates significantly better performance than other comparing methods. In practical research, the relevance of specific vocabulary pertaining to the task is usually unknown. In such case, multi-view text mining is a superior and promising strategy for text-based disease gene identification.

  1. Prioritizing tiger conservation through landscape genetics and habitat linkages.

    Science.gov (United States)

    Yumnam, Bibek; Jhala, Yadvendradev V; Qureshi, Qamar; Maldonado, Jesus E; Gopal, Rajesh; Saini, Swati; Srinivas, Y; Fleischer, Robert C

    2014-01-01

    Even with global support for tiger (Panthera tigris) conservation their survival is threatened by poaching, habitat loss and isolation. Currently about 3,000 wild tigers persist in small fragmented populations within seven percent of their historic range. Identifying and securing habitat linkages that connect source populations for maintaining landscape-level gene flow is an important long-term conservation strategy for endangered carnivores. However, habitat corridors that link regional tiger populations are often lost to development projects due to lack of objective evidence on their importance. Here, we use individual based genetic analysis in combination with landscape permeability models to identify and prioritize movement corridors across seven tiger populations within the Central Indian Landscape. By using a panel of 11 microsatellites we identified 169 individual tigers from 587 scat and 17 tissue samples. We detected four genetic clusters within Central India with limited gene flow among three of them. Bayesian and likelihood analyses identified 17 tigers as having recent immigrant ancestry. Spatially explicit tiger occupancy obtained from extensive landscape-scale surveys across 76,913 km(2) of forest habitat was found to be only 21,290 km(2). After accounting for detection bias, the covariates that best explained tiger occupancy were large, remote, dense forest patches; large ungulate abundance, and low human footprint. We used tiger occupancy probability to parameterize habitat permeability for modeling habitat linkages using least-cost and circuit theory pathway analyses. Pairwise genetic differences (FST) between populations were better explained by modeled linkage costs (r>0.5, p<0.05) compared to Euclidean distances, which was in consonance with observed habitat fragmentation. The results of our study highlight that many corridors may still be functional as there is evidence of contemporary migration. Conservation efforts should provide legal status

  2. Lidar observations at prioritized sites for GOSAT validation

    Science.gov (United States)

    Uchino, O.; Morino, I.; Sakai, T.; Izumi, T.; Nagai, T.; Shibata, T.; Hiroshi, O.; Arai, K.; Liley, B.; Bagtasa, G.

    2016-12-01

    The Thermal And Near infrared Sensor for carbon Observation-Fourier Transform Spectrometer (TANSO-FTS) onboard the Greenhouse gases Observing SATellite (GOSAT) measures the Short Wavelength InfraRed (SWIR) spectra of sunlight reflected by the earth surface and atmosphere. The column-averaged dry air mole fractions of carbon dioxide and methane (XCO2 and XCH4, hereafter GOSAT data) retrieved from the TANSO-FTS SWIR spectra could be influenced by aerosol and cirrus could particles. To investigate their influences on the GOSAT data, we deployed two-wavelength (532 and 1064 nm) polarization lidar systems at the Total Carbon Column Observing Network (TCCON) sites of Lauder in New Zealand, Tsukuba, Saga and Rikubetsu in Japan as prioritized validation sites. Vertical profiles of particle backscattering coefficients, backscatter wavelength exponent and total depolarization ratio were obtained by these lidar systems. Based on these physical parameters, we found that the particles had influence on GOSAT XCO2 at Tsukuba and Saga. These lidars detected increases in stratospheric aerosols by the volcanic eruptions of Sarychev Peak, Puyehue-Cordon Caulle, Nabro and Calbuco during 2009 through 2015, which might impact on GOSAT XCO2. Furthermore, we developed an improved version of lidar for validation of GOSAT-2 which will be launched in 2018. The improved lidar can measure the particle extinction-to-backscatter ratio and water vapor mixing ratio profiles up to 5 km in nighttime using N2 and H2O Raman scattering besides above-mentioned physical parameters. This lidar will be installed at Burgos in Philippines with a TCCON FTS in early 2017. We present the observational results of particles and their influences on the GOSAT data.

  3. Prioritizing tiger conservation through landscape genetics and habitat linkages.

    Directory of Open Access Journals (Sweden)

    Bibek Yumnam

    Full Text Available Even with global support for tiger (Panthera tigris conservation their survival is threatened by poaching, habitat loss and isolation. Currently about 3,000 wild tigers persist in small fragmented populations within seven percent of their historic range. Identifying and securing habitat linkages that connect source populations for maintaining landscape-level gene flow is an important long-term conservation strategy for endangered carnivores. However, habitat corridors that link regional tiger populations are often lost to development projects due to lack of objective evidence on their importance. Here, we use individual based genetic analysis in combination with landscape permeability models to identify and prioritize movement corridors across seven tiger populations within the Central Indian Landscape. By using a panel of 11 microsatellites we identified 169 individual tigers from 587 scat and 17 tissue samples. We detected four genetic clusters within Central India with limited gene flow among three of them. Bayesian and likelihood analyses identified 17 tigers as having recent immigrant ancestry. Spatially explicit tiger occupancy obtained from extensive landscape-scale surveys across 76,913 km(2 of forest habitat was found to be only 21,290 km(2. After accounting for detection bias, the covariates that best explained tiger occupancy were large, remote, dense forest patches; large ungulate abundance, and low human footprint. We used tiger occupancy probability to parameterize habitat permeability for modeling habitat linkages using least-cost and circuit theory pathway analyses. Pairwise genetic differences (FST between populations were better explained by modeled linkage costs (r>0.5, p<0.05 compared to Euclidean distances, which was in consonance with observed habitat fragmentation. The results of our study highlight that many corridors may still be functional as there is evidence of contemporary migration. Conservation efforts should

  4. Molecular replacement studies on crystal structure of DesBl-B2 Despentapeptide (B26-B30) insulin

    Institute of Scientific and Technical Information of China (English)

    刁家升; 万柱礼; 常文瑞; 梁栋材

    1997-01-01

    Using the crystal structure of Despentapeptide (B26-B30) insulin (DPI) as the search model, the crystal structure of DesBl-B2 Despentapeptide (B26-B30) insulin (DesBl-2 DPI) has been studied by the molecular replacement method. There is one DesBl-2 DPI molecule in each crystallographic asymmetric unit. The cross rotation function search and the translation function search show apparent peaks and thus determine the orientation and position of DesBl-2 DPI molecule in the cell respectively. The subsequent three-dimensional structural rebuilding and refine-ment of DesBl-2 DPI molecule confirm the results by molecular replacement method.

  5. Evaluer des études de gestion des entreprises : combiner des éléments principales avec des éléments pratiques

    NARCIS (Netherlands)

    Pennink, B.J.W.

    2002-01-01

    Evaluer la recherche de gestion demande une combinaison des critères classiques et des critères pratiques. Par cette combinaison il est possible de trouver une réponse cerrecte concernant la validité et l'effet de la recherche. Dans cet article nous allons décrire comment une combinaison des

  6. Alimentation des tortues terrestres herbivores

    OpenAIRE

    Morin, Nicolas

    2015-01-01

    Chez les tortues, la plupart des affections rencontrées sont directement ou indirectement liées à un défaut dans les conditions d’entretien et notamment à une alimentation inadéquate. Les ouvrages de référence ne proposent généralement que des rations qualitatives déterminées empiriquement. Ce travail se veut une synthèse bibliographique des différents travaux qui ont été menés sur les tortues terrestres herbivores, dont le but est de dégager les paramètres physiologiques sous-jacents au ...

  7. LES APPROCHES PSYCHOSOCIOLOGIQUES DES ORGANISATIONS

    Directory of Open Access Journals (Sweden)

    Deaconu Alecxandrina

    2008-05-01

    Full Text Available Les préoccupations pour bien comprendre la complexité des organisations sont bien connues dans la théorie et la pratique du management. La motivation la plus fréquente pour toutes les recherches et les investigationes faites a été fondée sur le besoin de savoir gérer les situations diverses en vue de maximiser la performance organisationnelle. En ce qui nous concerne, pour enrichir les informations disponibles, nous voulons élargir, dans notre communication, les approches traditionelles, focaliser l’attention sur la dimension psychologiques des organisations et présenter les mécanismes qui favorisent l’implication des salariés.

  8. L’Internet des objets

    OpenAIRE

    Benghozi, Pierre-Jean; Bureau, Sylvain; Massit-Folléa, Françoise

    2012-01-01

    L’ « internet des objets » est une dimension majeure de l’internet du futur. Mais tout le monde ne s’accorde pas encore sur sa définition, ni sur la mesure de son importance économique ou des risques qu’il induit. L’étude de nombreux rapports prospectifs et l’observation des innovations d’ores et déjà engagées a permis de mettre en relief les incertitudes techniques, économiques et socio-politiques qui pèsent sur cette véritable mutation programmée de l’internet et de proposer une approche eu...

  9. L’Internet des objets

    OpenAIRE

    Benghozi, Pierre-Jean; Bureau, Sylvain; Massit-Folléa, Françoise

    2012-01-01

    L’ « internet des objets » est une dimension majeure de l’internet du futur. Mais tout le monde ne s’accorde pas encore sur sa définition, ni sur la mesure de son importance économique ou des risques qu’il induit. L’étude de nombreux rapports prospectifs et l’observation des innovations d’ores et déjà engagées a permis de mettre en relief les incertitudes techniques, économiques et socio-politiques qui pèsent sur cette véritable mutation programmée de l’internet et de proposer une approche eu...

  10. A Comparative Study of Software Requirement, Elicitation, Prioritization and Decision Making.

    Directory of Open Access Journals (Sweden)

    Pradeep Kumar. G

    2016-04-01

    Full Text Available The failure of many software systems are mainly due to the lack of the requirement engineering. Where software requirement play a very vital role in the field of software engineering. The main task of the requirement engineering are eliciting the requirements from the customer and to prioritize those requirements to make decisions in the software design. Prioritization of the software requirement is very much useful in giving priority within the set of requirements. Requirement prioritization is very much important when there are strict constraints on schedule and the resources, then the software engineer must take some decisions on neglecting or to give prioritization to some of the requirements that are to be added to the project which makes it successful. This paper is the frame work of comparison of various techniques and to propose a most competent method among them

  11. Modeling Personalized Email Prioritization: Classification-based and Regression-based Approaches

    Energy Technology Data Exchange (ETDEWEB)

    Yoo S.; Yang, Y.; Carbonell, J.

    2011-10-24

    Email overload, even after spam filtering, presents a serious productivity challenge for busy professionals and executives. One solution is automated prioritization of incoming emails to ensure the most important are read and processed quickly, while others are processed later as/if time permits in declining priority levels. This paper presents a study of machine learning approaches to email prioritization into discrete levels, comparing ordinal regression versus classier cascades. Given the ordinal nature of discrete email priority levels, SVM ordinal regression would be expected to perform well, but surprisingly a cascade of SVM classifiers significantly outperforms ordinal regression for email prioritization. In contrast, SVM regression performs well -- better than classifiers -- on selected UCI data sets. This unexpected performance inversion is analyzed and results are presented, providing core functionality for email prioritization systems.

  12. ExpoCast: Exposure Science for Prioritization and Toxicity Testing (T)

    Science.gov (United States)

    The US EPA National Center for Computational Toxicology (NCCT) has a mission to integrate modern computing and information technology with molecular biology to improve Agency prioritization of data requirements and risk assessment of chemicals. Recognizing the critical need for ...

  13. Arete - candidate gene prioritization using biological network topology with additional evidence types

    National Research Council Canada - National Science Library

    Artem Lysenko; Keith Anthony Boroevich; Tatsuhiko Tsunoda

    2017-01-01

    ... of the largest possible fraction of all available data. Results We have developed an easily accessible framework that links two established network-based gene prioritization approaches with a supporting isolation forest-based integrative ranking method...

  14. Invasive Plant Species and Area Prioritization Report: Kern National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — On August 4-5, 2015 a workshop was held at the Kern National Wildlife Refuge (NWR) headquarters to prioritize species and area targets for inventory. Participants at...

  15. Prioritizing sewer rehabilitation projects using AHP-PROMETHEE II ranking method.

    Science.gov (United States)

    Kessili, Abdelhak; Benmamar, Saadia

    2016-01-01

    The aim of this paper is to develop a methodology for the prioritization of sewer rehabilitation projects for Algiers (Algeria) sewer networks to support the National Sanitation Office in its challenge to make decisions on prioritization of sewer rehabilitation projects. The methodology applies multiple-criteria decision making. The study includes 47 projects (collectors) and 12 criteria to evaluate them. These criteria represent the different issues considered in the prioritization of the projects, which are structural, hydraulic, environmental, financial, social and technical. The analytic hierarchy process (AHP) is used to determine weights of the criteria and the Preference Ranking Organization Method for Enrichment Evaluations (PROMETHEE II) method is used to obtain the final ranking of the projects. The model was verified using the sewer data of Algiers. The results have shown that the method can be used for prioritizing sewer rehabilitation projects.

  16. [Mapping stakeholders' preferences in prioritization criteria for horizon scanning in healthcare technologies].

    Science.gov (United States)

    Nascimento, Aline do; Vidal, Avila Teixeira; Almeida, Rosimary Terezinha de

    2016-08-01

    Filtration and prioritization are two basics steps in horizon scanning systems. This article aimed to map stakeholders' preferences in the Brazilian Unified National Health System (SUS) regarding filtration and prioritization criteria. Two filtration criteria (time horizon and innovation) and eight prioritization criteria (relevance to epidemiology, health policies, and clinical practice; potential impact on SUS budget, healthcare providers' costs, and mortality; safety; and legal, ethical, and social aspects) were selected. Multiple correspondence analysis was used to map stakeholders' preferences within and between groups. Two groups were more homogeneous and determinant for selection of prioritization criteria. Stakeholders' professional experience had more influence than institutional affiliations. The approach showed transparent criteria selection and analysis of stakeholders' individual preferences.

  17. Value of Information: A Tool to Improve Research Prioritization and Reduce Waste

    OpenAIRE

    Cosetta Minelli; Gianluca Baio

    2015-01-01

    In a Guest Editorial, Cosetta Minelli and Gianluca Baio explain how VOI analysis can prioritize research projects by identifying uncertainty in existing knowledge and then estimating expected benefits from reducing that uncertainty.

  18. Value of Information: A Tool to Improve Research Prioritization and Reduce Waste.

    Directory of Open Access Journals (Sweden)

    Cosetta Minelli

    2015-09-01

    Full Text Available In a Guest Editorial, Cosetta Minelli and Gianluca Baio explain how VOI analysis can prioritize research projects by identifying uncertainty in existing knowledge and then estimating expected benefits from reducing that uncertainty.

  19. Value of Information: A Tool to Improve Research Prioritization and Reduce Waste.

    Science.gov (United States)

    Minelli, Cosetta; Baio, Gianluca

    2015-09-01

    In a Guest Editorial, Cosetta Minelli and Gianluca Baio explain how VOI analysis can prioritize research projects by identifying uncertainty in existing knowledge and then estimating expected benefits from reducing that uncertainty.

  20. Ranking Vaccines : A Prioritization Software Tool: Phase II: Prototype of a Decision-Support System

    National Research Council Canada - National Science Library

    Committee on Identifying and Prioritizing New Preventive Vaccines for Development, Phase II; Board on Population Health and Public Health Practice; Board on Global Health; Institute of Medicine; Kinpritma Sangha; Charles Phelps; Dennis Fryback; Rino Rappuoli; Rose Marie Martinez; Lonnie King

    2013-01-01

    SMART Vaccines--Strategic Multi-Attribute Ranking Tool for Vaccines--is a prioritization software tool developed by the Institute of Medicine that utilizes decision science and modeling to help inform...

  1. 13 CFR 107.1520 - How a Licensee computes and allocates Prioritized Payments to SBA.

    Science.gov (United States)

    2010-01-01

    ... BUSINESS ADMINISTRATION SMALL BUSINESS INVESTMENT COMPANIES SBA Financial Assistance for Licensees... represents your Accumulated Prioritized Payments, unearned Adjustments and unearned Charges. (2) Distribution Account. The Distribution Account is a liability account. Its balance represents your unpaid...

  2. Prioritization of Water Resources Inventory Assessments (WRIA) and 6 Year Plan for Region 8 Refuges

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Regional management have requested that a prioritization process be developed for Region 8 for development and completion of Water Resources Inventory and...

  3. Role of Requirements Elicitation & Prioritization to Optimize Quality in Scrum Agile Development

    Directory of Open Access Journals (Sweden)

    Aneesa Rida Asghar

    2016-12-01

    Full Text Available One of most common aspect with traditional software development is managing requirements. As requirements emerge throughout the software development process and thus are needed to be addressed through proper communication and integration between stakeholders, developers and documentation. Agile methodology is an innovative and iterative process that supports changing requirements and helps in addressing changes throughout the development process. Requirements are elicited at the beginning of every software development process and project (product and latter are prioritized according to their importance to the market and to the product itself. One of the most important and influencing steps while making a software product is requirements prioritization. Prioritizing requirements helps the software team to understand the existence and importance of a particular requirement, its importance of use and its urgency to time to market. There are many requirements prioritization techniques with their relative strength and weaknesses. Otherwise many of them fail to take account all the factors that must be considered while prioritizing requirements such as cost, value, risk, time to market, number of requirements and effect of non-functional requirements on functional requirements. There are several requirements prioritization methodologies that aid in decision making but importantly many lacks to account the important factors that have significant influence in prioritizing requirements. A requirement prioritization methodology based on several factors such as time to market, cost, risk etc has been proposed. The proposed model is expected to overcome this lack. In sprints, requirements will be prioritized both on the basis of influencing factors such as cost, value, risk, time to market etc. and through the effect of non-functional requirements over functional requirements. This will improve the overall quality of software product when it is included in

  4. Troubleshooting Requests e-mail Confirmation

    CERN Multimedia

    TS Department

    2004-01-01

    In an ongoing effort to improve quality of the repair requests, a new e-mail confirmation automatic system will be implemented starting from the 21st October. All repair requests transmitted to the TCR (72201) or the FM Helpdesk (77777) will be confirmed in an e-mail to the requestor, provided that the latter has a valid e-mail address in the HR database. The e-mail will contain a reference number, a brief description of the problem, the location and a contact where more information can be obtained. A second e-mail will be sent when the processing of the repair request is finished. We hope that this initiative will improve the transparency and quality of our service. Helpdesk Troubleshooting Requests (reminder) We remind you that all the repair requests and other communication concerning the CERN machine buildings have to be transmitted to the TCR via 72201, whereas the ones concerning tertiary buildings are handled directly by the FM helpdesk under the phone number 77777, i.e. problems on systems and equ...

  5. [Cutaneous gnathostomiasis, first confirmed case in Colombia].

    Science.gov (United States)

    Jurado, Leonardo F; Palacios, Diana M; López, Rocío; Baldión, Margarita; Matijasevic, Eugenio

    2015-01-01

    Gnathostomiasis is a parasitic zoonosis caused by some species of helminthes belonging to the genus Gnathostoma . It has a wide clinical presentation and its diagnosis is a challenge. Tropical and subtropical countries are endemic, and its transmission is associated with eating raw or undercooked meat from fresh water animals. Increasing global tourism and consuming exotic foods have produced a noticeable rise in cases of the disease in the last decades. However, in our country, there has not been any confirmed case of gnathostomiasis previously reported. We present the case of a 63-year-old Colombian man with an international travel history, who presented with gastrointestinal symptoms. During the hospital stay, he developed a cutaneous lesion on the upper right abdominal quadrant, where later, a larva was found. A morphological study allowed us to identify it as Gnathostoma spinigerum . As such, this is the first report of an imported case of gnathostomiasis confirmed in Colombia. This article describes the principles, etiology, pathogenic cycle and treatment of this disease with special considerations to our patient´s particular features.

  6. Requirements Prioritization Based on Benefit and Cost Prediction: A Method Classification Framework

    OpenAIRE

    2008-01-01

    In early phases of the software development process, requirements prioritization necessarily relies on the specified requirements and on predictions of benefit and cost of individual requirements. This paper induces a conceptual model of requirements prioritization based on benefit and cost. For this purpose, it uses Grounded Theory. We provide a detailed account of the procedures and rationale of (i) how we obtained our results and (ii) how we used them to form the basis for a framework for ...

  7. Prioritizing Zoonotic Diseases: Differences in Perspectives Between Human and Animal Health Professionals in North America.

    Science.gov (United States)

    Ng, V; Sargeant, J M

    2016-05-01

    Zoonoses pose a significant burden of illness in North America. Zoonoses represent an additional threat to public health because the natural reservoirs are often animals, particularly wildlife, thus eluding control efforts such as quarantine, vaccination and social distancing. As there are limited resources available, it is necessary to prioritize diseases in order to allocate resources to those posing the greatest public health threat. Many studies have attempted to prioritize zoonoses, but challenges exist. This study uses a quantitative approach, conjoint analysis (CA), to overcome some limitations of traditional disease prioritization exercises. We used CA to conduct a zoonoses prioritization study involving a range of human and animal health professionals across North America; these included epidemiologists, public health practitioners, research scientists, physicians, veterinarians, laboratory technicians and nurses. A total of 699 human health professionals (HHP) and 585 animal health professionals (AHP) participated in this study. We used CA to prioritize 62 zoonotic diseases using 21 criteria. Our findings suggest CA can be used to produce reasonable criteria scores for disease prioritization. The fitted models were satisfactory for both groups with a slightly better fit for AHP compared to HHP (84.4% certainty fit versus 83.6%). Human-related criteria were more influential for HHP in their decision to prioritize zoonoses, while animal-related criteria were more influential for AHP resulting in different disease priority lists. While the differences were not statistically significant, a difference of one or two ranks could be considered important for some individuals. A potential solution to address the varying opinions is discussed. The scientific framework for disease prioritization presented can be revised on a regular basis by updating disease criteria to reflect diseases as they evolve over time; such a framework is of value allowing diseases of

  8. How well do test case prioritization techniques support statistical fault localization

    OpenAIRE

    Tse, TH; Jiang, B.; Zhang, Z; Chen, TY

    2009-01-01

    In continuous integration, a tight integration of test case prioritization techniques and fault-localization techniques may both expose failures faster and locate faults more effectively. Statistical fault-localization techniques use the execution information collected during testing to locate faults. Executing a small fraction of a prioritized test suite reduces the cost of testing, and yet the subsequent fault localization may suffer. This paper presents the first empirical study to examine...

  9. Using Decision Analysis in Evaluation and Prioritization of Technologies for Long Term Stewardship

    Energy Technology Data Exchange (ETDEWEB)

    Nadeau, Jennifer L; Byers, James Clifford; Harbour, Gerald Lee; Hill, Susan Gardiner; Nickelson, Reva Anne; Richardson, John Grant; Southworth, Finis Hio; Weingartner, Charles Brooks

    2002-08-01

    The purpose of this paper is to describe a systematic approach to assess and prioritize technology concepts and systems for future research and development (R&D) funding. This paper discusses the analysis and rationale used in developing an evaluation process to assist those engaged in prioritizing technologies. This paper will explain the developed evaluation process, discuss the methodology, and summarize the rationale underlying the process.

  10. Using Decision Analysis in Evaluation and Prioritization of Technologies for Long Term Stewardship

    Energy Technology Data Exchange (ETDEWEB)

    Nadeau, J.L.; Byers, J.; Harbour, J.L.; Hill, S.; Nickelson, R.A.; Richardson, J.G.; Soto, R.; Weingartner, C.B.

    2002-05-13

    The purpose of this paper is to describe a systematic approach to assess and prioritize technology concepts and systems for future research and development (R and D) funding. This paper discusses the analysis and rationale used in developing an evaluation process to assist those engaged in prioritizing technologies. This paper will explain the developed evaluation process, discuss the methodology, and summarize the rationale underlying the process.

  11. Abondance et stratification verticale des elements dans l'atmosphere des etoiles mercure-manganese

    Science.gov (United States)

    Thiam, Mouhamadou

    Les étoiles mercure-manganèse appartiennent à la famille des étoiles chimiquement particulières. Elles présentent d'importants excès de mercure et de manganèse par rapport au soleil. Ces anomalies d'abondance sont généralement expliquées par la théorie de la diffusion atomique, jouant possiblementun rôle important au sein de leurs atmosphères. Cette thèse a pour but, dans un premier temps, de déterminer les abondances d'un grand nombre d'éléments (C, O, Mg, Si, P, S, Ca, Sc, Ti, Cr, Mn, Fe, Sr, Hg) peuplant l'atmosphère de quatre étoiles mercure-manganèse (HD 71066, HD 175640, HD 178065 et HD 221507). La seconde étape consiste à vérifier la présence d'une quelconque dépendance de l'abondance de ces éléments par rapport à la profondeur de formation des raies. Une variation de l'abondance par rapport à la profondeur, c'est-à-dire stratification, apporterait la preuve observationnelle de la présence de la diffusion atomique au sein de l'atmosphère de ces étoiles, ainsi que des contraintes servant à l'amélioration des modèles théoriques. Les spectres des étoiles étudiées sont obtenus à partir de l'archive de l'ESO- UVES. Les raies investiguées se situent à des longueurs d'onde plus grandes que celle du saut de Balmer oû le signal sur bruit, après normalisation, est supérieur à 300. Parmi les quatre étoiles investiguées, uniquement de la stratification du manganèse a été découverte dans l'atmosphère de l'étoile HD 178065. L'abondance du manganèse augmente significativement (environ 0.7 dex) sur l'intervalle t 5000 sondé entre -3.8 et -2.5. Ceci est la première détection de stratification du manganèse dans une étoile de type HgMn. Pour HD 175640, des indices de stratification du manganèse existent, mais l'étude d'autres spectres aiderait à confirmer ou non, la stratification de cet élément.

  12. Géographie des cryptarchies

    Directory of Open Access Journals (Sweden)

    Gilles Fumey

    2002-06-01

    Full Text Available Si toute la surface du globe est appropriée, certains territoires sont encore revendiqués par des personnes ou petits groupes usurpateurs, conquérants ou aventuriers. Leur «conquête» porte sur des espaces physiques ou virtuels (internet. Elle traduit avec constance dans l'histoire le rôle considérable de l'ancrage territorial qui reste, pour l'homme, un antidote à toutes les formes d'organisation qui le dépassent.

  13. Cardiotoxicité des psychotropes

    OpenAIRE

    TAHIRI, Abdallah

    2013-01-01

    Même à dose thérapeutique, les médicaments psychotropes sont susceptibles d'engendrer des troubles du rythme cardiaque graves avec risque létal concourant à expliquer la pré valence de la mort subite dans la population psychiatrique. Les situations cliniques à risque telles que poly médication (des psychotropes entre eux ou d'un psychotrope avec un non psychotrope allongeur de QTc), interactions médicamenteuses aussi bien pharmacodynamiques que pharmacocinétiques, traitement pa...

  14. Physique statistique des Fluides Classiques

    OpenAIRE

    Aslangul, Claude

    2006-01-01

    0 - Préambule.Préambule, table des matières1 - Rappels sur la description d'un système à l'équilibre thermodynamiqueQuelques propriétés des systèmes macroscopiques. Nature statistique de l'entropie. Grandeurs internes et grandeurs externes. Relations thermodynamiques fondamentales. Potentiels thermodynamiques. Ensembles microcanonique, canonique, grand-canonique et isotherme - isobare. Exemple: fonction de partition d'un fluide classique. Principe variationnel pour l'énergie libre.2 - Stabili...

  15. Die Entwicklung des Innovationsmanagements an der Universitätsbibliothek Bern

    Directory of Open Access Journals (Sweden)

    Petra Redmond

    2015-11-01

    management include close links to project management as well as the introduction of product management. La gestion de l’innovation a pour but le développement actif de processus de transformation permettant à une bibliothèque de réagir rapidement aux changements dynamiques de son environnement. Être innovant signifie donc évoluer en permanence, ce qui implique le renouvellement et l’évaluation continus des processus, des structures et des priorités. Pour cette raison, lors de la mise en place d’une gestion de l’innovation à la Bibliothèque universitaire de Berne, la décision a été prise d’effectuer une évaluation après deux ans afin d’ajuster les processus et les missions principales à la situation actuelle. Les résultats ont démontré la nécessité de se concentrer sur des priorités stratégiques et d’encourager une culture interne de l’innovation. Dans ce contexte, une nouvelle priorité a été donnée au développement d’une gestion systématique de la clientèle. Un contact étroit avec la gestion de projets et la mise en place d’une gestion des produits sont également considérés comme des mesures favorisant une gestion réussie de l’innovation.

  16. A computational framework for the prioritization of disease-gene candidates.

    Science.gov (United States)

    Browne, Fiona; Wang, Haiying; Zheng, Huiru

    2015-01-01

    The identification of genes and uncovering the role they play in diseases is an important and complex challenge. Genome-wide linkage and association studies have made advancements in identifying genetic variants that underpin human disease. An important challenge now is to identify meaningful disease-associated genes from a long list of candidate genes implicated by these analyses. The application of gene prioritization can enhance our understanding of disease mechanisms and aid in the discovery of drug targets. The integration of protein-protein interaction networks along with disease datasets and contextual information is an important tool in unraveling the molecular basis of diseases. In this paper we propose a computational pipeline for the prioritization of disease-gene candidates. Diverse heterogeneous data including: gene-expression, protein-protein interaction network, ontology-based similarity and topological measures and tissue-specific are integrated. The pipeline was applied to prioritize Alzheimer's Disease (AD) genes, whereby a list of 32 prioritized genes was generated. This approach correctly identified key AD susceptible genes: PSEN1 and TRAF1. Biological process enrichment analysis revealed the prioritized genes are modulated in AD pathogenesis including: regulation of neurogenesis and generation of neurons. Relatively high predictive performance (AUC: 0.70) was observed when classifying AD and normal gene expression profiles from individuals using leave-one-out cross validation. This work provides a foundation for future investigation of diverse heterogeneous data integration for disease-gene prioritization.

  17. Prioritization methodology for the monitoring of active pharmaceutical ingredients in hospital effluents.

    Science.gov (United States)

    Daouk, Silwan; Chèvre, Nathalie; Vernaz, Nathalie; Bonnabry, Pascal; Dayer, Pierre; Daali, Youssef; Fleury-Souverain, Sandrine

    2015-09-01

    The important number of active pharmaceutical ingredients (API) available on the market along with their potential adverse effects in the aquatic ecosystems, lead to the development of prioritization methods, which allow choosing priority molecules to monitor based on a set of selected criteria. Due to the large volumes of API used in hospitals, an increasing attention has been recently paid to their effluents as a source of environmental pollution. Based on the consumption data of a Swiss university hospital, about hundred of API has been prioritized following an OPBT approach (Occurrence, Persistence, Bioaccumulation and Toxicity). In addition, an Environmental Risk Assessment (ERA) allowed prioritizing API based on predicted concentrations and environmental toxicity data found in the literature for 71 compounds. Both prioritization approaches were compared. OPBT prioritization results highlight the high concern of some non steroidal anti-inflammatory drugs and antiviral drugs, whereas antibiotics are revealed by ERA as potentially problematic to the aquatic ecosystems. Nevertheless, according to the predicted risk quotient, only the hospital fraction of ciprofloxacin represents a risk to the aquatic organisms. Some compounds were highlighted as high-priority with both methods: ibuprofen, trimethoprim, sulfamethoxazole, ritonavir, gabapentin, amoxicillin, ciprofloxacin, raltegravir, propofol, etc. Analyzing consumption data and building prioritization lists helped choosing about 15 API to be monitored in hospital wastewaters. The API ranking approach adopted in this study can be easily transposed to any other hospitals, which have the will to look at the contamination of their effluents.

  18. Gestion des résultats comptables : l'influence de la politique financière, de la performance et du contrôle

    OpenAIRE

    Mard, Yves

    2004-01-01

    International audience; Cette recherche porte sur les déterminants de la gestion des résultats au sein des entreprises françaises cotées. Nous étudions la relation entre la gestion des résultats (mesurée à partir des accruals) et plusieurs caractéristiques de la firme (politique financière, performance boursière, contrôle) afin de tester sept hypothèses de gestion des résultats. Les analyses confirmant plusieurs hypothèses et suggèrent que les déterminants de la gestion des résultats dépenden...

  19. Gestion des résultats comptables : l'influence de la politique financière, de la performance et du contrôle

    OpenAIRE

    Mard, Yves

    2004-01-01

    International audience; Cette recherche porte sur les déterminants de la gestion des résultats au sein des entreprises françaises cotées. Nous étudions la relation entre la gestion des résultats (mesurée à partir des accruals) et plusieurs caractéristiques de la firme (politique financière, performance boursière, contrôle) afin de tester sept hypothèses de gestion des résultats. Les analyses confirmant plusieurs hypothèses et suggèrent que les déterminants de la gestion des résultats dépenden...

  20. Can weak lensing surveys confirm BICEP2 ?

    CERN Document Server

    Chisari, Nora Elisa; Schmidt, Fabian

    2014-01-01

    The detection of B-modes in the Cosmic Microwave Background (CMB) polarization by the BICEP2 experiment, if interpreted as evidence for a primordial gravitational wave background, has enormous ramifications for cosmology and physics. It is crucial to test this hypothesis with independent measurements. A gravitational wave background leads to B-modes in galaxy shape correlations (shear) both through lensing and tidal alignment effects. Since the systematics and foregrounds of galaxy shapes and CMB polarization are entirely different, a detection of a cross-correlation between the two observables would provide conclusive proof for the existence of a primordial gravitational wave background. We find that upcoming weak lensing surveys will be able to detect the cross-correlation between B-modes of the CMB and galaxy shapes. However, this detection is not sufficient to confirm or falsify the hypothesis of a primordial origin for CMB B-mode polarization.

  1. Efficacy of ibandronate: a long term confirmation.

    Science.gov (United States)

    Di Munno, Ombretta; Delle Sedie, Andrea

    2010-01-01

    Data deriving from randomized clinical trials, observational studies and meta-analyses, including treatment regimens unlicensed for use in clinical practice, clearly support that 150 mg once-monthly oral and 3 mg quarterly i.v. doses of ibandronate are associated with efficacy, safety and tolerability; notably both these marketed regimens, which largely correspond to ACE ≥10.8 mg, may in addition provide a significant efficacy on non-vertebral and clinical fracture (Fx) efficacy. The MOBILE and the DIVA LTE studies confirmed a sustained efficacy of monthly oral and quarterly i.v. regimens respectively, over 5 years. Furthermore, improved adherence rates with monthly ibandronate, deriving from studies evaluating large prescription databases, promise to enhance fracture protection and decrease the social and economic burden of postmenopausal osteoporosis.

  2. Automatic earthquake confirmation for early warning system

    Science.gov (United States)

    Kuyuk, H. S.; Colombelli, S.; Zollo, A.; Allen, R. M.; Erdik, M. O.

    2015-07-01

    Earthquake early warning studies are shifting real-time seismology in earthquake science. They provide methods to rapidly assess earthquakes to predict damaging ground shaking. Preventing false alarms from these systems is key. Here we developed a simple, robust algorithm, Authorizing GRound shaking for Earthquake Early warning Systems (AGREEs), to reduce falsely issued alarms. This is a network threshold-based algorithm, which differs from existing approaches based on apparent velocity of P and S waves. AGREEs is designed to function as an external module to support existing earthquake early warning systems (EEWSs) and filters out the false events, by evaluating actual shaking near the epicenter. Our retrospective analyses of the 2009 L'Aquila and 2012 Emilia earthquakes show that AGREEs could help an EEWS by confirming the epicentral intensity. Furthermore, AGREEs is able to effectively identify three false events due to a storm, a teleseismic earthquake, and broken sensors in Irpinia Seismic Network, Italy.

  3. Spectroscopic Confirmation of the Pisces Overdensity

    CERN Document Server

    Kollmeier, Juna A; Shectman, Stephen; Thompson, Ian B; Preston, George W; Simon, Joshua D; Crane, Jeffrey D; Ivezić, Željko; Sesar, Branimir

    2009-01-01

    We present spectroscopic confirmation of the "Pisces Overdensity", also known as "Structure J", a photometric overdensity of RR Lyrae stars discovered by the Sloan Digital Sky Survey (SDSS) at an estimated photometric distance of ~85kpc. We measure radial velocities for 8 RR Lyrae stars within Pisces. We find that 5 of the 8 stars have heliocentric radial velocities within a narrow range of -87 km/s < v < -67 km/s, suggesting that the photometric overdensity is mainly due to a physically associated system, probably a dwarf galaxy or a disrupted galaxy. Two of the remaining 3 stars differ from one another by only 9 km/s, but it would be premature to identify them as a second system.

  4. OGM Information des consommateurs et séparation des filières OGM/non-OGM

    Directory of Open Access Journals (Sweden)

    Valceschini Egizio

    2000-09-01

    importantes qu’elle soulève2. L’argumentation en faveur d’un étiquetage distinctif repose sur le postulat que la présence ou non d’OGM est l’information pertinente pour le consommateur, celle qu’il recherche en priorité, avant les caractéristiques concernant la conservation, le goût du produit ou le respect de l’environnement par exemple. À supposer que cela soit établi, il reste à déterminer laquelle de l’allégation positive (du type « contient des OGM » ou de l’allégation négative (du type « non-OGM », « sans OGM » ou « sans utilisation d’OGM » est la plus pertinente. Dans tous les cas, il est nécessaire de savoir s’il est possible, en termes de coûts et de fiabilité, de mettre en oeuvre de manière efficace, un système de gestion de cette information sur la base d’une séparation des filières « avec » et « sans OGM ». Il sera donc également nécessaire d’évaluer le coût de l’information fournie sur l’étiquette (le coût de la ségrégation des filières et le coût de la garantie que cette ségrégation est efficace, c’est-à-dire d’évaluer si les coûts de la traçabilité et des contrôles permettent d’assurer la crédibilité de l’allégation. Les enjeux de pertinence et de faisabilité se rejoignent à propos de la question de savoir si un simple étiquetage universel, clair et lisible peut suffire à susciter une offre et une demande qui satisfassent les consommateurs, ainsi que les attentes des citoyens, dans un contexte où, bien entendu, les pouvoirs publics appliquent des critères très stricts d’autorisation de mise sur le marché.

  5. Peste des petits ruminants outbreaks in White Nile State, Sudan

    Directory of Open Access Journals (Sweden)

    Osama M. Ishag

    2015-02-01

    Full Text Available Eight outbreaks of peste des petits ruminants in sheep and goats were reported in White Nile State, Sudan, between 2008 and 2009. A mortality rate of 4.2% was reported across the different outbreaks. Clinically the disease was characterised by high fever, ocular and nasal discharge, pneumonia, ulceration of the mucous membranes, diarrhoea and death. The postmortem findings included necrotic lesions in the mouth and gastrointestinal tract, and swollen, oedematous lymph nodes associated with the lungs and intestine. Of the 209 serum samples tested by competitive enzyme-linked immunosorbent assay, 113 (54% were found positive. Peste des petits ruminants virus was confirmed in tissues, nasal swabs and blood samples by immunocapture enzyme-linked immunosorbent assay, reverse-transcription polymerase chain reaction and isolation of the virus in culture of lamb testicle cells.

  6. Peste des petits ruminants outbreaks in White Nile State, Sudan.

    Science.gov (United States)

    Ishag, Osama M; Saeed, Intisar K; Ali, Yahia H

    2015-08-21

    Eight outbreaks of peste des petits ruminants in sheep and goats were reported in White Nile State, Sudan, between 2008 and 2009. A mortality rate of 4.2% was reported across the different outbreaks. Clinically the disease was characterised by high fever, ocular and nasal discharge, pneumonia, ulceration of the mucous membranes, diarrhoea and death. The postmortem findings included necrotic lesions in the mouth and gastrointestinal tract, and swollen, oedematous lymph nodes associated with the lungs and intestine. Of the 209 serum samples tested by competitive enzyme-linked immunosorbent assay, 113 (54%) were found positive. Peste des petits ruminants virus was confirmed in tissues, nasal swabs and blood samples by immunocapture enzyme-linked immunosorbent assay, reverse-transcription polymerase chain reaction and isolation of the virus in culture of lamb testicle cells.

  7. Analyse automatique des données scripturales prétraitées par des outils de visualization

    Directory of Open Access Journals (Sweden)

    Bécotte-Boutin Hélène-Sarah

    2016-01-01

    Full Text Available Plusieurs méthodes pour analyser le processus d’écriture ont été utilisés afin de comprendre les stratégies des scripteurs. L’outil principal pour analyser le processus d’écriture est le fichier log, qui contient de façon exhaustive et détaillée l’ensemble des opérations effectuées par le scripteur lors de la rédaction d’un texte. Les données qui y sont emmagasinées sont de quantité considérable et lorsqu’elles ne sont pas préalablement traitées, elles sont hostiles à être analysées par l’humain. Parmi les outils d’analyse utilisés, les représentations du processus d’écriture permettent l’agrégation des données grâce à un pré-traitement. Les structures sous-jacentes des données ainsi représentées sont généralement plus propices à l’analyse que les données brutes. Cet article vise à démontrer différentes méthodes d’analyse automatique pouvant être appliquées à ces structures afin de trouver ou confirmer des structures et tendances à travers les données.

  8. La maison des mathématiques

    CERN Document Server

    Villani, Cédric; Moncorgé, Vincent

    2014-01-01

    Comment travaillent les mathématiciens ? C'est peut-être en se promenant dans les couloirs de la première des " maisons des mathématiques " de France, l'institut Henri Poincaré, que l'on trouvera quelques réponses. Le mathématicien Cédric Villani et le physicien Jean-Philippe Uzan nous invitent à découvrir cette discipline et ses acteurs. Au fil des pages on suit, à travers de superbes images signées du photographe Vincent Moncorgé, la façon dont se fabrique cette science qui reste souvent mystérieuse. Toutes les dimensions, scientifique, esthétique et poétique, des mathématiques sont convoquées grâce à des regards croisés : la diversité des inspirations des chercheurs, la source de leur créativité, l'imaginaire littéraire et artistique des mathématiques, la drôle de tribu des mathématiciens. Un voyage au cœur de cette " auberge espagnole " des mathématiques, campus " à la française " accueillant des centaines de chercheurs du monde entier, devenu un lieu d'émulation et d'éc...

  9. Horses, Cows, and Water Quality: Prioritizing Stream Restoration Sites

    Science.gov (United States)

    Lewis, R. A.; Ambers, R. K.

    2002-05-01

    In order to prioritize sites for a stream restoration project, water quality testing is being done in two small, partly forested watersheds on the Sweet Briar College campus east of the Blue Ridge Mountains of Virginia. The 1.3 km2 watershed of Dairy Creek contains a former dairy operation (now hayfields) and athletic fields. The 0.7 km2 watershed of Fern Creek contains an actively used horse pasture, riding, and stable area. The goals of this study are: (1) to determine which stream would benefit more from establishing or improving a forested riparian buffer zone and (2) to collect baseline water quality data which can be used in future years to monitor the effectiveness of the restoration project and other land management practices. Ten sites along the main stems and tributary streams in the two watersheds were chosen for water quality measurements. When water samples are collected, discharge is also determined at each site by dilution gauging using a conductivity logger. Water samples are tested in the lab for pH, turbidity, nitrate-nitrogen, orthophosphate, total phosphate, and fecal and total coloform bacteria. Total and orthophosphate and pH show no systematic downstream variation or difference between the two watersheds. In contrast, nitrate increases downstream and is positively correlated with conductivity and the upstream area of non-forested land. Nitrate concentrations in the Dairy Creek watershed are significantly higher than in the Fern Creek watershed. Fecal and total coloform counts also tend to be higher in Dairy than in Fern Creek, but the numbers vary widely. Although discharge increases downstream in a predictable way, it does not correlate well with any of the measured constituents. Despite the fact that the riding center is functioning but the dairy operation is not, these preliminary data suggest that water quality in the Dairy Creek system is poorer than in Fern Creek. Further investigation is needed to identify non-point sources of nutrient

  10. La compaction des sols forestiers en Wallonie

    OpenAIRE

    Destain, Marie-France

    2014-01-01

    Dans nos pays industrialisés, l’exploitation forestière fait appel à des machines de plus en plus lourdes pour assurer la vidange des coupes et le débardage des grumes. Lorsque des charges élevées sont appliquées sur des sols sensibles, une compaction du sol peut se produire entraînant une réduction de porosité, avec des conséquences néfastes sur la vitalité des peuplements. Au niveau environnemental, du fait de la compaction, l’infiltration de l’eau dans le sol est réduite, principalement...

  11. Etude des erreurs d'estimation des populations par la méthode des captures successives (DeLURY, 2 captures et des captures-recaptures (PETERSEN

    Directory of Open Access Journals (Sweden)

    LAURENT M.

    1978-01-01

    Full Text Available L'estimation des populations naturelles par capture-recapture et par captures successives est souvent entachée d'erreur car, dans de nombreux cas, l'hypothèse fondamentale d'égalité des probabilités de captures pour tous les individus dans le temps et dans l'espace n'est pas respectée. Dans le cas des populations de poissons envisagés ici, les captures ont lieu par la pêche électrique. On a pu chiffrer l'ordre de grandeur des erreurs systématiques faites sur l'estimation des peuplements, en fonction des conditions particulières, biotiques et abiotiques, des différents milieux inventoriés.

  12. Recherche des oscillations de Neutrinos $\

    CERN Document Server

    Gangler, E

    1997-01-01

    Le detecteur nomad, place sur le faisceau de neutrinos wide-band-beam du sps, de contamination en neutrino tau marginale, permet de rechercher des oscillations neutrino muon - tau dans la region de pertinence cosmologique et de distinguer statistiquement les courants charges des neutrinos tau essentiellement par leur mesure cinematique. Une large part du travail de these a donc ete consacree a la reconstruction des evenements dans les chambres a derive, cible instrumentee et cur de l'experience, dont la physique de detection est decrite. Une methode de recherche de traces fut developpee, utilisant certaines informations d'un autre sous-detecteur de nomad, le trd. Pour combler une perte d'efficacite de reconstruction, une methode de recherche de traces courtes s'appuyant sur des vertex deja constitues fut developpee en exploitant les potentialites du filtre de kalman, algorithme iteratif d'ajustement de traces. Ces methodes sont utilisees en production par la collaboration. Cette these porte sur la recherche d...

  13. Reduction des effectifs ou licenciements

    CERN Multimedia

    Maiani, Luciano

    2002-01-01

    "Vous faites un amalgame entre la reduction en cours des effectifs du CERN (organisation europeenne pour la recherche nucleaire) et les economies que le laboratoire doit realiser dans les cinq ans a venir pour financer le projet de grand collisionneur de hadrons (Le Monde du 4 septembre)" (1/2 page).

  14. Bangalore, ville des nouvelles technologies

    Directory of Open Access Journals (Sweden)

    Clarisse Didelon

    2003-06-01

    Full Text Available Bangalore est devenue la Silicon Valley de l’Inde. Une partie de ses habitants y vit à l’occidentale mais le reste de la population souffre de la croissance spectaculaire de la ville. Face à l’insuffisance des infrastructures, Bangalore devient de moins en moins attractive pour les entreprises internationales.

  15. Fusion of Large-Scale Genomic Knowledge and Frequency Data Computationally Prioritizes Variants in Epilepsy

    Science.gov (United States)

    Campbell, Ian M.; Rao, Mitchell; Arredondo, Sean D.; Lalani, Seema R.; Xia, Zhilian; Kang, Sung-Hae L.; Bi, Weimin; Breman, Amy M.; Smith, Janice L.; Bacino, Carlos A.; Beaudet, Arthur L.; Patel, Ankita; Cheung, Sau Wai; Lupski, James R.; Stankiewicz, Paweł; Ramocki, Melissa B.; Shaw, Chad A.

    2013-01-01

    Curation and interpretation of copy number variants identified by genome-wide testing is challenged by the large number of events harbored in each personal genome. Conventional determination of phenotypic relevance relies on patterns of higher frequency in affected individuals versus controls; however, an increasing amount of ascertained variation is rare or private to clans. Consequently, frequency data have less utility to resolve pathogenic from benign. One solution is disease-specific algorithms that leverage gene knowledge together with variant frequency to aid prioritization. We used large-scale resources including Gene Ontology, protein-protein interactions and other annotation systems together with a broad set of 83 genes with known associations to epilepsy to construct a pathogenicity score for the phenotype. We evaluated the score for all annotated human genes and applied Bayesian methods to combine the derived pathogenicity score with frequency information from our diagnostic laboratory. Analysis determined Bayes factors and posterior distributions for each gene. We applied our method to subjects with abnormal chromosomal microarray results and confirmed epilepsy diagnoses gathered by electronic medical record review. Genes deleted in our subjects with epilepsy had significantly higher pathogenicity scores and Bayes factors compared to subjects referred for non-neurologic indications. We also applied our scores to identify a recently validated epilepsy gene in a complex genomic region and to reveal candidate genes for epilepsy. We propose a potential use in clinical decision support for our results in the context of genome-wide screening. Our approach demonstrates the utility of integrative data in medical genomics. PMID:24086149

  16. Fusion of large-scale genomic knowledge and frequency data computationally prioritizes variants in epilepsy.

    Directory of Open Access Journals (Sweden)

    Ian M Campbell

    Full Text Available Curation and interpretation of copy number variants identified by genome-wide testing is challenged by the large number of events harbored in each personal genome. Conventional determination of phenotypic relevance relies on patterns of higher frequency in affected individuals versus controls; however, an increasing amount of ascertained variation is rare or private to clans. Consequently, frequency data have less utility to resolve pathogenic from benign. One solution is disease-specific algorithms that leverage gene knowledge together with variant frequency to aid prioritization. We used large-scale resources including Gene Ontology, protein-protein interactions and other annotation systems together with a broad set of 83 genes with known associations to epilepsy to construct a pathogenicity score for the phenotype. We evaluated the score for all annotated human genes and applied Bayesian methods to combine the derived pathogenicity score with frequency information from our diagnostic laboratory. Analysis determined Bayes factors and posterior distributions for each gene. We applied our method to subjects with abnormal chromosomal microarray results and confirmed epilepsy diagnoses gathered by electronic medical record review. Genes deleted in our subjects with epilepsy had significantly higher pathogenicity scores and Bayes factors compared to subjects referred for non-neurologic indications. We also applied our scores to identify a recently validated epilepsy gene in a complex genomic region and to reveal candidate genes for epilepsy. We propose a potential use in clinical decision support for our results in the context of genome-wide screening. Our approach demonstrates the utility of integrative data in medical genomics.

  17. Fusion of large-scale genomic knowledge and frequency data computationally prioritizes variants in epilepsy.

    Science.gov (United States)

    Campbell, Ian M; Rao, Mitchell; Arredondo, Sean D; Lalani, Seema R; Xia, Zhilian; Kang, Sung-Hae L; Bi, Weimin; Breman, Amy M; Smith, Janice L; Bacino, Carlos A; Beaudet, Arthur L; Patel, Ankita; Cheung, Sau Wai; Lupski, James R; Stankiewicz, Paweł; Ramocki, Melissa B; Shaw, Chad A

    2013-01-01

    Curation and interpretation of copy number variants identified by genome-wide testing is challenged by the large number of events harbored in each personal genome. Conventional determination of phenotypic relevance relies on patterns of higher frequency in affected individuals versus controls; however, an increasing amount of ascertained variation is rare or private to clans. Consequently, frequency data have less utility to resolve pathogenic from benign. One solution is disease-specific algorithms that leverage gene knowledge together with variant frequency to aid prioritization. We used large-scale resources including Gene Ontology, protein-protein interactions and other annotation systems together with a broad set of 83 genes with known associations to epilepsy to construct a pathogenicity score for the phenotype. We evaluated the score for all annotated human genes and applied Bayesian methods to combine the derived pathogenicity score with frequency information from our diagnostic laboratory. Analysis determined Bayes factors and posterior distributions for each gene. We applied our method to subjects with abnormal chromosomal microarray results and confirmed epilepsy diagnoses gathered by electronic medical record review. Genes deleted in our subjects with epilepsy had significantly higher pathogenicity scores and Bayes factors compared to subjects referred for non-neurologic indications. We also applied our scores to identify a recently validated epilepsy gene in a complex genomic region and to reveal candidate genes for epilepsy. We propose a potential use in clinical decision support for our results in the context of genome-wide screening. Our approach demonstrates the utility of integrative data in medical genomics.

  18. TANK 50 BATCH 0 SALTSTONE FORMULATION CONFIRMATION

    Energy Technology Data Exchange (ETDEWEB)

    Langton, C.

    2006-06-05

    Savannah River National Laboratory (SRNL) personnel were requested to confirm the Tank 50 Batch 0 grout formulation per Technical Task Request, SSF-TTR-2006-0001 (task 1 of 2) [1]. Earlier Batch 0 formulation testing used a Tank 50 sample collected in September 2005 and is described elsewhere [2]. The current testing was performed using a sample of Tank 50 waste collected in May 2006. This work was performed according to the Technical Task and Quality Assurance Plan (TT/QAP), WSRC-RP-2006-00594 [3]. The salt solution collected from Tank 50 in May 2006 contained approximately 3 weight percent more solids than the sample collected in September 2005. The insoluble solids took longer to settle in the new sample which was interpreted as indicating finer particles in the current sample. The saltstone formulation developed for the September 2005 Tank 50 Batch 0 sample was confirmed for the May 2006 sample with one minor exception. Saltstone prepared with the Tank 50 sample collected in May 2006 required 1.5 times more Daratard 17 set retarding admixture than the saltstone prepared with the September In addition, a sample prepared with lower shear mixing (stirring with a spatula) had a higher plastic viscosity (57 cP) than samples made with higher shear mixing in a blender (23cP). The static gel times of the saltstone slurries made with low shear mixing were also shorter ({approx}32 minutes) than those for comparable samples made in the blender ({approx}47 minutes). The addition of the various waste streams (ETP, HEU-HCAN, and GPE-HCAN) to Tank 50 from September 2005 to May 2006 has increased the amount of set retarder, Daratard 17, required for processing saltstone slurries through the Saltstone facility. If these streams are continued to be added to Tank 50, the quantity of admixtures required to maintain the same processing conditions for the Saltstone facility will probably change and additional testing is recommended to reconfirm the Tank 50 Saltstone formulation.

  19. Prioritization of Delay Factors for NPP Construction Risk in International Project by Using AHP Methodology

    Energy Technology Data Exchange (ETDEWEB)

    Hossen, Muhammed Mufazzal; Kang, Sunkoo; Kim, Jonghyun [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

    2014-10-15

    construction delay of NPP. The main contribution of the work was the identification of main cause of NPP construction schedule delay for turnkey contractual approached international project in different level. The second contribution was a development of a multi-criteria decision making model for the prioritization of NPP construction delay risk factors. Finally, prioritization of delay factors in different levels of NPP construction delay risk factors were accomplished. The model is developed by using the AHP methodology. This study has produced results and insights that involve one of the most vital aspect which is the quantitative weights and ranking of factors that affect delay in NPP construction. Undoubtedly, it is a necessity in the NPP construction industry for the use of quantitative terms when it comes to schedule delay risk. The outcomes of this study confirm that the model is capable to support decision-makers to examine the strengths and weaknesses of factors in different level of the NPP construction phase. Decision makers of nuclear industry can understand the significance of different factors on NPP construction phase and they can apply risk informed decision making to avoid unexpected construction delay of NPP. This study finds the different party's importance in behind the construction schedule delay of NPP which constitutes main contractor (28.4%), regulatory authority (27.3%), Financial and Country Factor (23.5%), and utility (20.8%).The results show that the top most important 5 sub factors according to global weight in level 2 are delayed regulatory approval, country factor, inadequate completion of design before start of construction, slow procurement, manufacturing of equipment and delivery to the site for installation, and financial matters. This study finds top most important 10 sub-sub factors in the lowest level which are uncompromising regulatory criteria and conflicting licensing documents with existing regulations, robust design documents

  20. Osteoporose und Genetik des Knochenstoffwechsels

    Directory of Open Access Journals (Sweden)

    Obermayer-Pietsch B

    2002-01-01

    Full Text Available Osteoporose ist in hohem Maß genetisch determiniert. Neue Wege der molekularbiologischen Forschung haben sich in den letzten Jahren auf diesem Gebiet etabliert. "Gene mapping" mit polymorphen genetischen Markern auf der Suche nach Phänotyp-assoziierten Genen ist ein aufwendiges, aber vielversprechendes Verfahren und wird durch die Erkenntnisse des Human Genome Projects beschleunigt. So wurde jüngst u. a. das Low-density Lipoprotein 5-Gen als wichtig für den Knochenstoffwechsel identifiziert. Kandidaten-gene wie Hormonrezeptor-, Cytokin- oder Kollagen-Gene werden hinsichtlich ihrer Gen-Gen- und Gen-Umwelt- Interaktionen untersucht und erlauben neue funktionelle Einsichten in Erkrankungen des Knochenstoffwechsels. Mutationen der Kollagen-Gene sind bei einigen seltenen Erkrankungen, wie dem Osteoporose-Pseudogliom-Syndrom oder der Osteogenesis imperfecta gefunden worden, könnten aber auch für häufige Varianten von Bindegewebsstörungen wie der congenitalen Hüftdysplasie verantwortlich sein, die etwa 10 % der weiblichen kaukasischen Bevölkerung in unterschiedlichem Ausmaß betrifft. Osteoporose am Schenkelhals und erhöhte Gelenkslaxizität sowie andere generalisierte Veränderungen des Knochen- und Kollagenstoffwechsels können hier möglicherweise ebenfalls durch Störungen des Kollagen I alpha 1-Gens erklärt werden. In Summe können wir zahlreiche neue Einsichten in die Pathophysiologie des Skelettsystems erwarten, die uns auch neue Zugangswege für Diagnostik und Therapie unserer Patienten ermöglichen werden.

  1. L'astronomie des Anciens

    Science.gov (United States)

    Nazé, Yaël

    2009-04-01

    Quelle que soit la civilisation à laquelle il appartient, l'être humain cherche dans le ciel des réponses aux questions qu'il se pose sur son origine, son avenir et sa finalité. Le premier mérite de ce livre est de nous rappeler que l'astronomie a commencé ainsi à travers les mythes célestes imaginés par les Anciens pour expliquer l'ordre du monde et la place qu'ils y occupaient. Mais les savoirs astronomiques passés étaient loin d'être négligeables et certainement pas limités aux seuls travaux des Grecs : c'est ce que l'auteur montre à travers une passionnante enquête, de Stonehenge à Gizeh en passant par Pékin et Mexico, fondée sur l'étude des monuments anciens et des sources écrites encore accessibles. Les tablettes mésopotamiennes, les annales chinoises, les chroniques médiévales, etc. sont en outre d'une singulière utilité pour les astronomes modernes : comment sinon remonter aux variations de la durée du jour au cours des siècles, ou percer la nature de l'explosion qui a frappé tant d'observateurs en 1054 ? Ce livre offre un voyage magnifiquement illustré à travers les âges, entre astronomie et archéologie.

  2. Tambov. Le camp des Malgré Nous alsaciens et mosellans prisonniers des Russes

    OpenAIRE

    Claerr-Stamm, Gabrielle

    2012-01-01

    « La faim, le froid, l’injustice. Et puis le silence… Tambov égale silence. Silence de la grande majorité de ceux qui en sont revenus, silence dans les familles, silence des historiens, silence des archives, silence des écrivains et des artistes, silence de l’opinion publique ». « Il a fallu l’opiniâtre courage de poignées d’individus – anciens prisonniers, responsables d’associations, quelques élus, des historiens et des journalistes – pour que la parole et la reconnaissance trouvent progres...

  3. Vers une typologie des formes spatiales des limites de l’Europe

    OpenAIRE

    de Ruffray, Sophie

    2013-01-01

    Penser l’Europe et ses limites consiste souvent à rechercher une identité européenne, un projet ou des comportements communs dans l’espace. L’approche par les représentations mentales permet de compléter par des perspectives plus subjectives, la perception des frontières. Cet article, réalisé à partir des résultats de l’enquête du projet de recherches Eurobroadmap sur la vision de l’Europe dans le monde permet de mettre en évidence une typologie des formes spatiales des limites de l’Europe. D...

  4. Observational Confirmations of Spiral Density Wave Theory

    Science.gov (United States)

    Kennefick, Julia D.; Kennefick, Daniel; Shameer Abdeen, Mohamed; Berrier, Joel; Davis, Benjamin; Fusco, Michael; Pour Imani, Hamed; Shields, Doug; DMS, SINGS

    2017-01-01

    Using two techniques to reliably and accurately measure the pitch angles of spiral arms in late-type galaxies, we have compared pitch angles to directly measured black hole masses in local galaxies and demonstrated a strong correlation between them. Using the relation thus established we have developed a pitch angle distribution function of a statistically complete volume limited sample of nearby galaxies and developed a central black hole mass function for nearby spiral galaxies.We have further shown that density wave theory leads us to a three-way correlation between bulge mass, pitch angle, and disk gas density, and have used data from the Galaxy Disk Mass Survey to confirm this possible fundamental plane. Density wave theory also predicts that the pitch angle of spiral arms should change with observed waveband as each waveband is sampling a different stage in stellar population formation and evolution. We present evidence that this is indeed the case using a sample of galaxies from the Spitzer Infrared Nearby Galaxy Survey. Furthermore, the evolved spiral arms cross at the galaxy co-rotation radius. This gives a new method for determining the co-rotation radius of spiral galaxies that is found to agree with those found using previous methods.

  5. Quality assessment of Isfahan Medical Faculty web site electronic services and prioritizing solutions using analytic hierarchy process approach.

    Science.gov (United States)

    Hajrahimi, Nafiseh; Dehaghani, Sayed Mehdi Hejazi; Hajrahimi, Nargess; Sarmadi, Sima

    2014-01-01

    Implementing information technology in the best possible way can bring many advantages such as applying electronic services and facilitating tasks. Therefore, assessment of service providing systems is a way to improve the quality and elevate these systems including e-commerce, e-government, e-banking, and e-learning. This study was aimed to evaluate the electronic services in the website of Isfahan University of Medical Sciences in order to propose solutions to improve them. Furthermore, we aim to rank the solutions based on the factors that enhance the quality of electronic services by using analytic hierarchy process (AHP) method. Non-parametric test was used to assess the quality of electronic services. The assessment of propositions was based on Aqual model and they were prioritized using AHP approach. The AHP approach was used because it directly applies experts' deductions in the model, and lead to more objective results in the analysis and prioritizing the risks. After evaluating the quality of the electronic services, a multi-criteria decision making frame-work was used to prioritize the proposed solutions. Non-parametric tests and AHP approach using Expert Choice software. The results showed that students were satisfied in most of the indicators. Only a few indicators received low satisfaction from students including, design attractiveness, the amount of explanation and details of information, honesty and responsiveness of authorities, and the role of e-services in the user's relationship with university. After interviewing with Information and Communications Technology (ICT) experts at the university, measurement criteria, and solutions to improve the quality were collected. The best solutions were selected by EC software. According to the results, the solution "controlling and improving the process in handling users complaints" is of the utmost importance and authorities have to have it on the website and place great importance on updating this process

  6. Characterization of ovine Nectin-4, a novel peste des petits ruminants virus (PPRV) receptor

    Science.gov (United States)

    Small ruminants infected with peste des petits ruminants virus (PPRV) exhibit lesions typical of epithelial infection and necrosis. However, the only established host receptor for this virus is the immune cell marker signalling lymphocyte activation molecule (SLAM). We have confirmed that the ovine ...

  7. Administration et gestion des contrats XL

    CERN Document Server

    Senouf, J

    2000-01-01

    Les grands contrats de travaux génèrent un grand nombre de commandes (OSVC) passées par un grand nombre de responsables techniques. Ils sont généralement basés sur des bordereaux de prix associés à un éventail de conditions économiques adaptées aux besoins complexes et variés des multiples utilisateurs du CERN nécessitant des calculs sophistiqués. L'administration des commandes, le suivi des travaux et de la facturation doivent répondre aux besoins de tous les acteurs. Les responsables techniques doivent jouir de la plus large indépendance administrative dans le respect des règlements CERN et des conditions contractuelles. Le contrôle des métrés et décomptes doit être rigoureux et d'une traçabilité complète. L'utilisation des bases de données Oracle a déjà permis l'intégration des données administratives et techniques. Le Web nous invite à une communication totale et transparente entre les utilisateurs, les services techniques et les contractants. De nouveaux types de contrat so...

  8. Enquête de satisfaction des restaurants

    CERN Multimedia

    Staff Association

    2016-01-01

    Comité de surveillance des restaurants L’Association du personnel est représentée dans plusieurs comités dont le Comité de surveillance des restaurants (CSR) qui a pour mandat : de donner son avis sur toute question relative à la politique générale de l’Organisation en matière de restauration sur le site, y compris en ce qui concerne les termes et l’attribution des contrats d’exploitation des restaurants ; de définir dans le cadre des contrats d’exploitation des restaurants, les prestations correspondant aux besoins et, dans la mesure du possible, aux désirs du personnel ; de surveiller les prestations des restaurants, y compris en ce qui concerne la qualité et la préparation des produits ; de négocier avec les concessionnaires des restaurants au sujet des tarifs et de surveill...

  9. La territorialisation des politiques environnementales

    Directory of Open Access Journals (Sweden)

    Amédée Mollard

    2010-10-01

    Full Text Available Le point de départ de cet article est la grande variabilité de la pollution nitrique diffuse de l’eau due à l’agriculture. Celle-ci dépend en particulier du climat, des types de sol et des systèmes de production agricole. Nos recherches réalisées de façon interdisciplinaire à partir de deux sites différents en France, montrent que cette hétérogénéité spatio-temporelle conditionne les pratiques agricoles mises en œuvre pour réduire la pollution au niveau de la norme admise. De ce fait, les pratiques les plus « coût-efficaces » diffèrent d’un territoire à l’autre, en fonction des caractéristiques locales. Ces résultats mettent donc en évidence une efficacité potentielle d’une territorialisation des politiques publiques. En théorie, de telles politiques sont considérées comme optimales par les économistes, car elles incitent les agents à moduler leurs efforts en fonction de la sensibilité du milieu. Mais, selon les études empiriques, cet avantage serait annulé par un coût élevé de mise en œuvre, de contrôle et de surveillance. Pour maintenir leur avantage sur des politiques uniformes, les politiques territorialisées devraient être mises en œuvre à un niveau spatial optimal. Un tel niveau devrait au minimum atteindre un compromis entre l’économie réalisée grâce à une modulation adaptée aux conditions locales et les sur-coûts dus à la décentralisation des solutions mises en œuvre. Cet article analyse la pertinence d’une prise en compte de ces spécificités par des politiques territorialisées. L’efficacité d’une régulation différenciée de la pollution nitrique est étudiée ici en évaluant l’importance de la variabilité spatiale des paramètres physiques et des coûts de la territorialisation.The paper starts with the wide variability of nonpoint water nitrogenous pollution generated by agriculture. This variability depends especially on climate, soil types and farming

  10. Evaluation des systèmes existants pour le suivi à long terme des déformations des ponts

    OpenAIRE

    BURDET, Olivier; Muttoni, Aurelio

    2006-01-01

    Le projet de recherche Evaluation des systèmes existants pour le suivi à long terme des déformations des ponts a été initié dans le but de préparer sous forme condensée une présentation et une évaluation des systèmes de mesure existants pour le suivi à long terme des déformations de ponts ainsi que des recommandations en vue d’applications particulières. Ce sujet est d’actualité car d’une part il importe de gérer au mieux les ouvrages et les ressources et d’autre part parce que plusieurs cas ...

  11. Géographie des interfaces. Une nouvelle vision des territoires

    Directory of Open Access Journals (Sweden)

    Marie Redon

    2011-07-01

    Full Text Available Littéralement, une interface est une surface de séparation entre deux états distincts de la matière. Le terme, ayant cheminé de la physique à la biologie, et aussi désormais d’usage répandu en informatique. En géographie, l’usage du mot s’est développé dans les années 1980 et peut être défini comme un espace permettant la mise en relation de deux espaces/territoires différents, influencé par des échanges entre l’un et l’autre, et se distinguant par là-même des deux espaces contigus. Intégrant...

  12. Evaluation des performances des protocoles de routage Ad hoc

    OpenAIRE

    Boushaba, Abdelali; Oumsis, Mohammed; Benabbou, Rachid

    2010-01-01

    International audience; L'objectif de ce travail est d'une part, de confronter par la simulation, à l'aide de NS-2, les performances de quatre protocoles de routage Ad hoc: DSR, AODV, OLSR et DSDV et d'autre part, d'examiner l'impact de la charge du trafic, de la mobilité et de la densité des nœuds sur le comportement de ces protocoles. Les résultats montrent qu'il n'y a pas un protocole qui est favori pour tous les critères d'évaluation. En effet, chaque protocole a des comportements différe...

  13. DES13S2cmm: The First Superluminous Supernova from the Dark Energy Survey

    CERN Document Server

    Papadopoulos, A; Sullivan, M; Nichol, R C; Barbary, K; Biswas, R; Brown, P J; Covarrubias, R A; Finley, D A; Fischer, J A; Foley, R F; Goldstein, D; Gupta, R R; Kessler, R; Kovacs, E; Kuhlmann, S E; Lidman, C; March, M; Nugent, P E; Sako, M; Smith, R C; Spinka, H; Wester, W; Abbott, T M C; Abdalla, F; Allam, S S; Banerji, M; Bernstein, J P; Bernstein, R A; Carnero, A; da Costa, L N; DePoy, D L; Desai, S; Diehl, H T; Eifler, T; Evrard, A E; Flaugher, B; Frieman, J A; Gerdes, D; Gruen, D; Honscheid, K; James, D; Kuehn, K; Kuropatkin, N; Lahav, O; Maia, M A G; Makler, M; Marshall, J L; Merritt, K W; Miller, C J; Miquel, R; Ogando, R; Plazas, A A; Roe, N A; Romer, A K; Rykoff, E; Sanchez, E; Santiago, B X; Scarpine, V; Schubnell, M; Sevilla, I; Santos, M Soares-; Suchyta, E; Swanson, M; Tarle, G; Thaler, J; Tucker, D L; Wechsler, R H; Zuntz, J

    2015-01-01

    We present DES13S2cmm, the first spectroscopically-confirmed superluminous supernova (SLSN) from the Dark Energy Survey (DES). We briefly discuss the data and search algorithm used to find this event in the first year of DES operations, and outline the spectroscopic data obtained from the European Southern Observatory (ESO) Very Large Telescope to confirm its redshift (z = 0.663 +/- 0.001 based on the host-galaxy emission lines) and likely spectral type (type I). Using this redshift, we find M_U_peak = -21.05 +0.10 -0.09 for the peak, rest-frame U-band absolute magnitude, and find DES13S2cmm to be located in a faint, low metallicity (sub-solar), low stellar-mass host galaxy (log(M/M_sun) = 9.3 +/- 0.3); consistent with what is seen for other SLSNe-I. We compare the bolometric light curve of DES13S2cmm to fourteen similarly well-observed SLSNe-I in the literature and find it possesses one of the slowest declining tails (beyond +30 days rest frame past peak), and is the faintest at peak. Moreover, we find the b...

  14. Manned in Situ Confirmation of Lunar Ice

    Science.gov (United States)

    Gerené, S. P. B.; Hummeling, R. W. J.; Ockels, W. J.

    A study is performed to investigate the feasibility of a manned expedition to the Moon using the European Ariane-5 launcher. The primary objective of this lunar mission is to confirm the presence of water at the South-Pole craters. It is believed that these permanently shadowed craters contain water in the form of ice. Secondary objective is to perform lunar surface science and making a first step towards a lunar outpost. Early results show that a minimum of two Ariane-5 launches is required. In this `two Ariane' scenario the first launch will bring a Lunar Landing Vehicle (LLV) into low lunar orbit. The second will launch two astronauts in a Crew Transfer Vehicle into a rendez- vous trajectory with the LLV. Arrived at the Moon, the astronauts will enter the LLV, undock from the CTV and land at the designated site located near the rim of the South-Pole Shackleton crater. The transfer strategy for both spacecraft will be the so-called direct transfer, taking about four days. At arrival the LLV will start mapping the landing site at a ground resolution of one meter. As a consequence of the polar orbit, the CTV has to arrive fourteen days later and surface operations can take about twelve days, accumulating in a total mission-duration of 36 days. 32 days for the CTV and 22 days for the LLV. In case a `two Ariane' flight does not posses sufficient capabilities also a `three Ariane' scenario is developed, in which the LLV is split-up into two stages and launched separately. These two will dock at the Moon forming a descent stage and an ascent stage. The third launch will be a CTV. During surface operations, astronauts will set up a solar power unit, install the sample retrieval system and carry out surface science. Samples of the crater floor will be retrieved by means of a probe or robot guided along a cable suspended over the crater rim. Also, this paper shows the way in which European astronauts can be brought to the Moon for other future missions, like the

  15. Cochrane Airways Group reviews were prioritized for updating using a pragmatic approach.

    Science.gov (United States)

    Welsh, E; Stovold, E; Karner, C; Cates, C

    2015-03-01

    Cochrane Reviews should address the most important questions for guideline writers, clinicians, and the public. It is not possible to keep all reviews up-to-date, so the Cochrane Airways Group (CAG) decided to prioritize updates and new reviews without requesting additional resources. The aim of the objective was to develop pragmatic and transparent prioritization techniques to identify 25 to 35 high-priority updates from a total of 270 CAG Reviews and become more selective over which new reviews we publish. We used elements from existing prioritization processes, including existing health care uncertainties, expert opinion, and a decision tool. We did not conduct a full face-to-face workshop or an iterative group decision-making process. We prioritized 30 reviews in need of updating and aimed to update these within 2 years. Within the first 18 months, nine of these have been published. A pragmatic approach to prioritization can indicate priority reviews without an excessive drain on time and resources. The steps provide us with better control over the reviews in our scope and can be built on in the future. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  16. Prioritizing critical success factors for reverse logistics implementation using fuzzy-TOPSIS methodology

    Science.gov (United States)

    Agrawal, Saurabh; Singh, Rajesh K.; Murtaza, Qasim

    2016-11-01

    Electronics industry is one of the fastest growing industries in the world. In India also, there are high turnovers and growing demand of electronics product especially after post liberalization in early nineties. These products generate e-waste which has become big environmental issue. Industries can handle these e-waste and product returns efficiently by developing reverse logistics (RL) system. A thorough study of critical success factors (CSFs) and their ordered implementation is essential for successful RL implementation. The aim of the study is to review the CSFs, and to prioritize them for RL implementation in Indian electronics industry. Twelve CSFs were identified through literature review, and discussion with the experts from the Indian electronics industry. Fuzzy-Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) approach is proposed for prioritizing these CSFs. Perusal of literature indicates that fuzzy-TOPSIS has not been applied earlier for prioritization of CSFs in Indian electronics industry. Five Indian electronics companies were selected for evaluation of this methodology. Results indicate that most of the identified factors are crucial for the RL implementation. Top management awareness, resource management, economic factors, and contracts terms and conditions are top four prioritized factor, and process capabilities and skilled workers is the least prioritized factor. The findings will be useful for successful RL implementation in Indian electronics industry.

  17. An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.

    Science.gov (United States)

    Hsu, Yi-Hsiang; Zillikens, M Carola; Wilson, Scott G; Farber, Charles R; Demissie, Serkalem; Soranzo, Nicole; Bianchi, Estelle N; Grundberg, Elin; Liang, Liming; Richards, J Brent; Estrada, Karol; Zhou, Yanhua; van Nas, Atila; Moffatt, Miriam F; Zhai, Guangju; Hofman, Albert; van Meurs, Joyce B; Pols, Huibert A P; Price, Roger I; Nilsson, Olle; Pastinen, Tomi; Cupples, L Adrienne; Lusis, Aldons J; Schadt, Eric E; Ferrari, Serge; Uitterlinden, André G; Rivadeneira, Fernando; Spector, Timothy D; Karasik, David; Kiel, Douglas P

    2010-06-10

    Osteoporosis is a complex disorder and commonly leads to fractures in elderly persons. Genome-wide association studies (GWAS) have become an unbiased approach to identify variations in the genome that potentially affect health. However, the genetic variants identified so far only explain a small proportion of the heritability for complex traits. Due to the modest genetic effect size and inadequate power, true association signals may not be revealed based on a stringent genome-wide significance threshold. Here, we take advantage of SNP and transcript arrays and integrate GWAS and expression signature profiling relevant to the skeletal system in cellular and animal models to prioritize the discovery of novel candidate genes for osteoporosis-related traits, including bone mineral density (BMD) at the lumbar spine (LS) and femoral neck (FN), as well as geometric indices of the hip (femoral neck-shaft angle, NSA; femoral neck length, NL; and narrow-neck width, NW). A two-stage meta-analysis of GWAS from 7,633 Caucasian women and 3,657 men, revealed three novel loci associated with osteoporosis-related traits, including chromosome 1p13.2 (RAP1A, p = 3.6x10(-8)), 2q11.2 (TBC1D8), and 18q11.2 (OSBPL1A), and confirmed a previously reported region near TNFRSF11B/OPG gene. We also prioritized 16 suggestive genome-wide significant candidate genes based on their potential involvement in skeletal metabolism. Among them, 3 candidate genes were associated with BMD in women. Notably, 2 out of these 3 genes (GPR177, p = 2.6x10(-13); SOX6, p = 6.4x10(-10)) associated with BMD in women have been successfully replicated in a large-scale meta-analysis of BMD, but none of the non-prioritized candidates (associated with BMD) did. Our results support the concept of our prioritization strategy. In the absence of direct biological support for identified genes, we highlighted the efficiency of subsequent functional characterization using publicly available expression profiling relevant to the

  18. An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.

    Directory of Open Access Journals (Sweden)

    Yi-Hsiang Hsu

    2010-06-01

    Full Text Available Osteoporosis is a complex disorder and commonly leads to fractures in elderly persons. Genome-wide association studies (GWAS have become an unbiased approach to identify variations in the genome that potentially affect health. However, the genetic variants identified so far only explain a small proportion of the heritability for complex traits. Due to the modest genetic effect size and inadequate power, true association signals may not be revealed based on a stringent genome-wide significance threshold. Here, we take advantage of SNP and transcript arrays and integrate GWAS and expression signature profiling relevant to the skeletal system in cellular and animal models to prioritize the discovery of novel candidate genes for osteoporosis-related traits, including bone mineral density (BMD at the lumbar spine (LS and femoral neck (FN, as well as geometric indices of the hip (femoral neck-shaft angle, NSA; femoral neck length, NL; and narrow-neck width, NW. A two-stage meta-analysis of GWAS from 7,633 Caucasian women and 3,657 men, revealed three novel loci associated with osteoporosis-related traits, including chromosome 1p13.2 (RAP1A, p = 3.6x10(-8, 2q11.2 (TBC1D8, and 18q11.2 (OSBPL1A, and confirmed a previously reported region near TNFRSF11B/OPG gene. We also prioritized 16 suggestive genome-wide significant candidate genes based on their potential involvement in skeletal metabolism. Among them, 3 candidate genes were associated with BMD in women. Notably, 2 out of these 3 genes (GPR177, p = 2.6x10(-13; SOX6, p = 6.4x10(-10 associated with BMD in women have been successfully replicated in a large-scale meta-analysis of BMD, but none of the non-prioritized candidates (associated with BMD did. Our results support the concept of our prioritization strategy. In the absence of direct biological support for identified genes, we highlighted the efficiency of subsequent functional characterization using publicly available expression profiling relevant

  19. Marie-Pierre Lassus, Gaston Bachelard musicien. Une philosophie des silences et des timbres

    OpenAIRE

    Marida Rizzuti

    2012-01-01

    Marie-Pierre Lassus, Gaston Bachelard musicien. Une philosophie des silences et des timbres (Villeneuve d’Ascq, Presses Universitaires du Septentrion, 2010, 268 pp. ISBN: 978-275-740-1613) di     Marida Rizzuti

  20. Multi-action planning for threat management: a novel approach for the spatial prioritization of conservation actions.

    Science.gov (United States)

    Cattarino, Lorenzo; Hermoso, Virgilio; Carwardine, Josie; Kennard, Mark J; Linke, Simon

    2015-01-01

    Planning for the remediation of multiple threats is crucial to ensure the long term persistence of biodiversity. Limited conservation budgets require prioritizing which management actions to implement and where. Systematic conservation planning traditionally assumes that all the threats in priority sites are abated (fixed prioritization approach). However, abating only the threats affecting the species of conservation concerns may be more cost-effective. This requires prioritizing individual actions independently within the same site (independent prioritization approach), which has received limited attention so far. We developed an action prioritization algorithm that prioritizes multiple alternative actions within the same site. We used simulated annealing to find the combination of actions that remediate threats to species at the minimum cost. Our algorithm also accounts for the importance of selecting actions in sites connected through the river network (i.e., connectivity). We applied our algorithm to prioritize actions to address threats to freshwater fish species in the Mitchell River catchment, northern Australia. We compared how the efficiency of the independent and fixed prioritization approach varied as the importance of connectivity increased. Our independent prioritization approach delivered more efficient solutions than the fixed prioritization approach, particularly when the importance of achieving connectivity was high. By spatially prioritizing the specific actions necessary to remediate the threats affecting the target species, our approach can aid cost-effective habitat restoration and land-use planning. It is also particularly suited to solving resource allocation problems, where consideration of spatial design is important, such as prioritizing conservation efforts for highly mobile species, species facing climate change-driven range shifts, or minimizing the risk of threats spreading across different realms.

  1. Multi-action planning for threat management: a novel approach for the spatial prioritization of conservation actions.

    Directory of Open Access Journals (Sweden)

    Lorenzo Cattarino

    Full Text Available Planning for the remediation of multiple threats is crucial to ensure the long term persistence of biodiversity. Limited conservation budgets require prioritizing which management actions to implement and where. Systematic conservation planning traditionally assumes that all the threats in priority sites are abated (fixed prioritization approach. However, abating only the threats affecting the species of conservation concerns may be more cost-effective. This requires prioritizing individual actions independently within the same site (independent prioritization approach, which has received limited attention so far. We developed an action prioritization algorithm that prioritizes multiple alternative actions within the same site. We used simulated annealing to find the combination of actions that remediate threats to species at the minimum cost. Our algorithm also accounts for the importance of selecting actions in sites connected through the river network (i.e., connectivity. We applied our algorithm to prioritize actions to address threats to freshwater fish species in the Mitchell River catchment, northern Australia. We compared how the efficiency of the independent and fixed prioritization approach varied as the importance of connectivity increased. Our independent prioritization approach delivered more efficient solutions than the fixed prioritization approach, particularly when the importance of achieving connectivity was high. By spatially prioritizing the specific actions necessary to remediate the threats affecting the target species, our approach can aid cost-effective habitat restoration and land-use planning. It is also particularly suited to solving resource allocation problems, where consideration of spatial design is important, such as prioritizing conservation efforts for highly mobile species, species facing climate change-driven range shifts, or minimizing the risk of threats spreading across different realms.

  2. Étude des impacts écologiques du dynamisme spatio-temporel des ...

    African Journals Online (AJOL)

    4 nov. 2013 ... du changement des habitats naturels sur les espèces menacées de sa faune. ... le contexte des changements climatiques. La situation de la .... naturels des espèces de la faune menacée dans la région évo- luent au cours du ... distribution des espèces cibles a ensuite été cartographiée sur la couche ...

  3. Beeinflussung des Essentiellen Tremors und des Tremors beim Morbus Parkinson durch transkranielle Gleichstromstimulation

    OpenAIRE

    Hellriegel, Helge

    2010-01-01

    Ziel dieser Arbeit war es die Rolle des primärmotorischen Kortex bei der Entstehung und Weiterleitung des Essentiellen Tremors und des Tremors beim Morbus Parkinson zu untersuchen. Hierzu wurde eine transkranielle Gleichstromstimulation über dem primärmotorischen Kortex bei Patienten mit oben genannten Tremorsyndromen durchgeführt und die klinischen sowie elektrophysiologisch messbaren Änderungen des Tremors beurteilt.

  4. Contribution à la Gestion des Cercosporioses du bananier dues à ...

    African Journals Online (AJOL)

    SARAH

    31 mai 2017 ... the state of disease progression after each treatment. Results and applications ..... 2007, des logiciels SPSS (Statistical Package for Social. Sciences) version ... un facteur suivies d'un test de comparaison des moyennes des ...

  5. La gestion des adoptions internationales

    OpenAIRE

    Boéchat, Hervé

    2011-01-01

    Après les rumeurs nées lors du tsunami et le désastre avéré de L’Arche de Zoé, l’adoption – et plus généralement le sort des enfants – est devenue une préoccupation majeure en cas de catastrophe naturelle ou de conflit. Haïti, pays depuis longtemps ouvert à l’adoption internationale, n’a pas échappé à la polémique. Hervé Boéchat nous livre l’appréciation de son institution sur cet épisode qui n’a sans doute pas contribué à apaiser le ressentiment des Haïtiens contre la « communauté internati...

  6. Étude par diffraction des rayons X des vernis rouges des sigillées du sud de la Gaule. Les ateliers de la Graufesenque

    Science.gov (United States)

    Vendier, L.; Sciau, Ph.; Dooryhee, E.

    2002-07-01

    La Graufesenque (Millau, Aveyron) 1^rst and 2^nd, centuries AC Sigillata red slips have been studied by x-ray diffraction at ESRF and on a conventional diffractometer. Although x-ray diffraction is a non-destructive characterisation technique adapted to surface study, it has not been used so mutch for Sigillata slip characterisation. The poor quality of the slip surface can be an explanation. In this work we demonstrate that it is possible to get good quality diffraction diagrams on 20-120 AC Sigillata slips. The results confirm the productions homogeneity and the hypothesis about a non-local clay used for the slips. On a counterpart, the late (second half of 2^nd century AC) Sigillata study needs because of their crackled surface a high quality beam, which can only be accessible on a synchrotron installation. These productions seems to be more heterogeneous: some Sigillata present similar diffraction diagrams for the slip and ceramic body (same clay?), some others present results similar to the precedent production period ones. Les vernis rouges de poteries sigillées (I^er et II^e siècles) de la Graufesenque (Millau, Aveyron) ont été étudiés par diffraction des rayons X à la fois à l'ESRF et sur une installation classique de laboratoire. Bien que la diffraction des rayons X soit une technique adaptée à l'étude des surfaces, cette technique a jusqu'à présent assez peu servi dans l'examen de ces objets. Ceci peut en partie s'expliquer par le mauvais état de surface de certains vernis. Dans ce travail, nous montrons que moyennant quelques précautions, il est possible d'obtenir sur une installation classique de bons diffractogranunes des vernis des sigillées datés entre 20 et 120 ap. J.C. Les résultats confirment l'homogénéité de ces productions et l'hypothèse selon laquelle ces vernis n'ont pas été fabriqués à partir des argiles locales du jurassique environnant le site. Par contre, l'étude des sigillées tardives de la deuxième moitié du

  7. Identification of the causative gene for Simmental arachnomelia syndrome using a network-based disease gene prioritization approach.

    Directory of Open Access Journals (Sweden)

    Shihui Jiao

    Full Text Available Arachnomelia syndrome (AS, mainly found in Brown Swiss and Simmental cattle, is a congenital lethal genetic malformation of the skeletal system. In this study, a network-based disease gene prioritization approach was implemented to rank genes in the previously reported ∼7 Mb region on chromosome 23 associated with AS in Simmental cattle. The top 6 ranked candidate genes were sequenced in four German Simmental bulls, one known AS-carrier ROMEL and a pooled sample of three known non-carriers (BOSSAG, RIFURT and HIRMER. Two suspicious mutations located in coding regions, a mis-sense mutation c.1303G>A in the bystin-like (BYSL gene and a 2-bp deletion mutation c.1224_1225delCA in the molybdenum cofactor synthesis step 1 (MOCS1 gene were detected. Bioinformatic analysis revealed that the mutation in MOCS1 was more likely to be the causative mutation. Screening the c.1224_1225delCA site in 383 individuals from 12 cattle breeds/lines, we found that only the bull ROMEL and his 12 confirmed progeny carried the mutation. Thus, our results confirm the conclusion of Buitkamp et al. that the 2-bp deletion mutation c.1224_1225delCA in exon 11 of the MOCS1 gene is causative for AS in Simmental cattle. Furthermore, a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP was developed to detect the causative mutation.

  8. Catalogue ostéologique des oiseaux

    NARCIS (Netherlands)

    Oort, van E.D.

    1907-01-01

    Je le crois utile de faire précéder le présent Catalogue par quelques remarques. J’ai énuméré autant que possible les parties, qui font défaut aux squelettes. L’absence de plusieurs osselets, comme des doigts, des vertèbres caudales, des côtes etc. au même échantillon, est indiqué par „incomplet” ou

  9. Le piratage des biens d'information

    OpenAIRE

    Paul Belleflamme

    2003-01-01

    Où se situe le juste milieu entre les propos alarmistes des uns (“le piratage tue la production musicale!”) et les appels libertaires des autres (“l'accès à toute information doit être libre!”) ? Une analyse économique simple nous permet de mieux comprendre les enjeux et de dégager des pistes de réflexion pour l'avenir.

  10. A List of Household Objects for Robotic Retrieval Prioritized by People with ALS (Version 092008)

    CERN Document Server

    Choi, Young Sang; Kemp, Charles C

    2009-01-01

    This technical report is designed to serve as a citable reference for the original prioritized object list that the Healthcare Robotics Lab at Georgia Tech released on its website in September of 2008. It is also expected to serve as the primary citable reference for the research associated with this list until the publication of a detailed, peer-reviewed paper. The original prioritized list of object classes resulted from a needs assessment involving 8 motor-impaired patients with amyotrophic lateral sclerosis (ALS) and targeted, in-person interviews of 15 motor-impaired ALS patients. All of these participants were drawn from the Emory ALS Center. The prioritized object list consists of 43 object classes ranked by how important the participants considered each class to be for retrieval by an assistive robot. We intend for this list to be used by researchers to inform the design and benchmarking of robotic systems, especially research related to autonomous mobile manipulation.

  11. Prioritization of Companion Animal Transmissible Diseases for Policy Intervention in Europe

    DEFF Research Database (Denmark)

    Cito, F.; Rijks, J.; Rantsios, A.T.

    2016-01-01

    on methods described by the World Organisation for Animal Health (OIE). Modifications were applied to allow for the paucity of specific information on companion animal transmissible diseases. The OIE method was also adapted to the subject and to the regional scope of the interprofessional network addressing......A number of papers have been published on the prioritization of transmissible diseases in farm animals and wildlife, based either on semiquantitative or truly quantitative methods, but there is no published literature on the prioritization of transmissible diseases in companion animals....... In this study, available epidemiological data for diseases transmissible from companion animals to man were analysed with the aim of developing a procedure suitable for their prioritization within a European framework. A new method and its associated questionnaire and scoring system were designed based...

  12. Prioritization methodology using hazard analysis results at Los Alamos National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Sasser, M.K.; Hall, M.; Stack, D. [Los Alamos National Lab., NM (United States); Brooks, D.G. [Arizona State Univ. (United States)

    1995-09-01

    Risk management activities, such as prioritizing risk-reducing projects, often are commissioned for facilities as special tasks supported by special task forces and conducted independently of other on-going risk assessment and risk management activities. Many DOE facilities have completed hazard analyses (HAs) as part of their efforts to upgrade their SARs to meet the new DOE standard that was issued in 1994. Although a complete SAR would contain more resource allocation information than the HA, the HA usually is completed before the SAR. This paper describes how SAR results, and particularly HA results, can be used directly to support managers` risk-based prioritization of project funding. This can reduce the time to conduct prioritization modeling, increase the quality of the results, and, perhaps most importantly, integrate the results into the on-going risk management activities of the site.

  13. Product prioritization in a two-stage food production system with intermediate storage

    DEFF Research Database (Denmark)

    Akkerman, Renzo; van Donk, Dirk Pieter

    2007-01-01

    In the food-processing industry, usually a limited number of storage tanks for intermediate storage is available, which are used for different products. The market sometimes requires extremely short lead times for some products, leading to prioritization of these products, partly through the dedi......In the food-processing industry, usually a limited number of storage tanks for intermediate storage is available, which are used for different products. The market sometimes requires extremely short lead times for some products, leading to prioritization of these products, partly through...... the dedication of a storage tank. This type of situation has hardly been investigated, although planners struggle with it in practice. This paper aims at investigating the fundamental effect of prioritization and dedicated storage in a two-stage production system, for various product mixes. We show...

  14. Hesitant Fuzzy Linguistic Multicriteria Decision-Making Method Based on Generalized Prioritized Aggregation Operator

    Directory of Open Access Journals (Sweden)

    Jia-ting Wu

    2014-01-01

    Full Text Available Based on linguistic term sets and hesitant fuzzy sets, the concept of hesitant fuzzy linguistic sets was introduced. The focus of this paper is the multicriteria decision-making (MCDM problems in which the criteria are in different priority levels and the criteria values take the form of hesitant fuzzy linguistic numbers (HFLNs. A new approach to solving these problems is proposed, which is based on the generalized prioritized aggregation operator of HFLNs. Firstly, the new operations and comparison method for HFLNs are provided and some linguistic scale functions are applied. Subsequently, two prioritized aggregation operators and a generalized prioritized aggregation operator of HFLNs are developed and applied to MCDM problems. Finally, an illustrative example is given to illustrate the effectiveness and feasibility of the proposed method, which are then compared to the existing approach.

  15. Hesitant fuzzy linguistic multicriteria decision-making method based on generalized prioritized aggregation operator.

    Science.gov (United States)

    Wu, Jia-ting; Wang, Jian-qiang; Wang, Jing; Zhang, Hong-yu; Chen, Xiao-hong

    2014-01-01

    Based on linguistic term sets and hesitant fuzzy sets, the concept of hesitant fuzzy linguistic sets was introduced. The focus of this paper is the multicriteria decision-making (MCDM) problems in which the criteria are in different priority levels and the criteria values take the form of hesitant fuzzy linguistic numbers (HFLNs). A new approach to solving these problems is proposed, which is based on the generalized prioritized aggregation operator of HFLNs. Firstly, the new operations and comparison method for HFLNs are provided and some linguistic scale functions are applied. Subsequently, two prioritized aggregation operators and a generalized prioritized aggregation operator of HFLNs are developed and applied to MCDM problems. Finally, an illustrative example is given to illustrate the effectiveness and feasibility of the proposed method, which are then compared to the existing approach.

  16. Performance Evaluation of the Loop Buffer Switch Under Prioritized Traffic and Optical Regeneration

    Directory of Open Access Journals (Sweden)

    Devesh Pratap Singh

    2012-12-01

    Full Text Available In this paper, an all-optical regenerator based, photonic packet switch architecture, which consists of the fiber loop for the storage of the contending packets, is considered. In the loop buffer, the available buffer space may not be fully utilized due to the limited re-circulation count of the data placed on buffer. This limit can be counteracted by placing a pool of regenerators inside the buffer. As optical regenerators are costly devices, hence they should be placed optimally in the buffer. The simulations results are presented by consider Prioritized and non – prioritized traffic. It is shown in the results that regeneration of data is essential if prioritized traffic has to be considered.

  17. Exclusion of agricultural lands in spatial conservation prioritization strategies: consequences for biodiversity and ecosystem service representation.

    Science.gov (United States)

    Durán, América P; Duffy, James P; Gaston, Kevin J

    2014-10-01

    Agroecosystems have traditionally been considered incompatible with biological conservation goals, and often been excluded from spatial conservation prioritization strategies. The consequences for the representativeness of identified priority areas have been little explored. Here, we evaluate these for biodiversity and carbon storage representation when agricultural land areas are excluded from a spatial prioritization strategy for South America. Comparing different prioritization approaches, we also assess how the spatial overlap of priority areas changes. The exclusion of agricultural lands was detrimental to biodiversity representation, indicating that priority areas for agricultural production overlap with areas of relatively high occurrence of species. By contrast, exclusion of agricultural lands benefits representation of carbon storage within priority areas, as lands of high value for agriculture and carbon storage overlap little. When agricultural lands were included and equally weighted with biodiversity and carbon storage, a balanced representation resulted. Our findings suggest that with appropriate management, South American agroecosystems can significantly contribute to biodiversity conservation.

  18. Congestion Control Protocol for Wireless Sensor Networks Handling Prioritized Heterogeneous Traffic

    CERN Document Server

    Monowar, Muhammad Mostafa; Pathan, Al-Sakib Khan; Hong, Choong Seon

    2008-01-01

    Heterogeneous applications could be assimilated within the same wireless sensor network with the aid of modern motes that have multiple sensor boards on a single radio board. Different types of data generated from such types of motes might have different transmission characteristics in terms of priority, transmission rate, required bandwidth, tolerable packet loss, delay demands etc. Considering a sensor network consisting of such multi-purpose nodes, in this paper we propose Prioritized Heterogeneous Traffic-oriented Congestion Control Protocol (PHTCCP) which ensures efficient rate control for prioritized heterogeneous traffic. Our protocol uses intra-queue and inter-queue priorities for ensuring feasible transmission rates of heterogeneous data. It also guarantees efficient link utilization by using dynamic transmission rate adjustment. Detailed analysis and simulation results are presented along with the description of our protocol to demonstrate its effectiveness in handling prioritized heterogeneous traf...

  19. 79 Influences des rejets des eaux usées domestiques dans les ...

    African Journals Online (AJOL)

    PR BOKO

    L'usage agricole d'effluents liquides peut être considéré comme une ... Rares sont celles qui sont alimentées par une eau de source [8]. ... nutriments, des Eléments Traces Métalliques (ETM) [9], des micro- ... essentiels pour la croissance des plantes ; ils provoquent cependant une prolifération excessive d' algues. La.

  20. Ensemble distribution models in conservation prioritization: from consensus predictions to consensus reserve networks

    Science.gov (United States)

    Meller, Laura; Cabeza, Mar; Pironon, Samuel; Barbet-Massin, Morgane; Maiorano, Luigi; Georges, Damien; Thuiller, Wilfried

    2014-01-01

    Aim Conservation planning exercises increasingly rely on species distributions predicted either from one particular statistical model or, more recently, from an ensemble of models (i.e. ensemble forecasting). However, it has not yet been explored how different ways of summarizing ensemble predictions affect conservation planning outcomes. We evaluate these effects and compare commonplace consensus methods, applied before the conservation prioritization phase, to a novel method that applies consensus after reserve selection. Location Europe. Methods We used an ensemble of predicted distributions of 146 Western Palaearctic bird species in alternative ways: four different consensus methods, as well as distributions discounted with variability, were used to produce inputs for spatial conservation prioritization. In addition, we developed and tested a novel method, in which we built 100 datasets by sampling the ensemble of predicted distributions, ran a conservation prioritization analysis on each of them and averaged the resulting priority ranks. We evaluated the conservation outcome against three controls: (i) a null control, based on random ranking of cells; (2) the reference solution, based on an expert-refined dataset; and (3) the independent solution, based on an independent dataset. Results Networks based on predicted distributions were more representative of rare species than randomly selected networks. Alternative methods to summarize ensemble predictions differed in representativeness of resulting reserve networks. Our novel method resulted in better representation of rare species than pre-selection consensus methods. Main conclusions Retaining information about the variation in the predicted distributions throughout the conservation prioritization seems to provide better results than summarizing the predictions before conservation prioritization. Our results highlight the need to understand and consider model-based uncertainty when using predicted

  1. Fuzzy-based risk prioritization for a hydrogen refueling facility in Malaysia

    Institute of Scientific and Technical Information of China (English)

    Hue-yee CHONG; Mahidzal DAHARI; Hwa-jen YAP; Ying-tai LOONG

    2013-01-01

    Hydrogen is starting to be mentioned as an alternative fuel to replace the fossil fuel in future transportation applications due to its characteristics of zero greenhouse gas emission and high energy efficiency.Before hydrogen fuel and its facilities can be introduced to the public,relevant safety issues and its hazards must be assessed in order to avoid any chance of injury or loss.While a traditional risk assessment has difficulty in prioritizing the risk of failure modes,this paper proposes a new fuzzy-based risk evaluation technique which uses fuzzy value to prioritize the risk of various scenarios.In this study,the final risk of each failure modes was prioritized by using the MATLAB fuzzy logic tool box with a combination of two assessments.The first assessment was concerned with the criteria which affected the actual probability of occurrence.This assessment considered the availability of the standard that was applied to prevent the likelihood of the scenario occurring.On the other hand,the second assessment was focused on evaluating the consequence of the failure by taking into account the availability of detection and the complexity of the failure rather than only the severity of the scenarios.A total of 87 failure scenarios were identified using failure modes and effect analysis(FMEA)procedures on hydrogen refueling station models.Fuzzy-based assessments were performed through risk prioritizing various failure scenarios with a fuzzy value(0 to 1)and risk level(low,medium,and high)while a traditional risk assessment approach presented the risks only in forms of level(low,medium,and/or high).Availability of the fuzzy value enabled further prioritizing on the risk results that fell in the same level of risk.This study concluded that fuzzy-based risk evaluation is able to further prioritize the decisions when compared with a traditional risk assessment method.

  2. Présentation des textes

    OpenAIRE

    Freitag, Michel

    2015-01-01

    Les textes choisis n’ont pas pour but la reconstitution ou le survol d’une carrière, mais la mise en valeur des étapes saillantes d’une double éclosion, celle d’Elizabeth Cady Stanton comme féministe et avec elle celle du mouvement de défense des droits des femmes aux États-Unis. Un tel objectif implique donc des limites temporelles en amont et en aval de l’événement fondateur que fut la Convention de Seneca Falls en 1848, origine du texte non moins fondateur de la Déclaration de sentiments r...

  3. Annuaire du Bureau des longitudes - 2006

    Science.gov (United States)

    Imcce; Bureau Des Longitudes

    2005-07-01

    This annual publication provides ephemerides and data to the use of professionnal and amateur astronomers. Divided in 11 chapters it covers concordance of various calendars, explanation of fondamental astronomy and various time scales, explanation for the use of ephemerides; tables provide ephemerides (positions, rise/set/passage) of the Sun and the Moon, planets, planetary satellites, asteroids, comets, bright stars; data and explanation for the physical observation of the surface of the Sun, the Moon, and planets; chart of the sky and a list of constellations and galaxies; prediction and ephemerides for astronomical phenomenon: occultation by the moon, stellar occultations by asteroids and appulses, solar eclipses and lunar eclipses; and an additional review about a hot scientific topic, this year: "Legendre et le méridien terrestre, 200 ans après". Cette publication annuelle fournit des éphémérides et des données à l'usage des astronomes professionnels et des astronomes amateurs. Composée de 11 chapitres elle comprend les rubriques sur les différents calendriers et leurs concordance, les fêtes légales en France, les dates et décrets sur les heures légales en France métropolitaine ; une introduction à l'astronomie fondamentale et aux différentes échelles de temps, des explications sur l'utilisation des éphémérides ; des tables fournissent les éphémérides (positions, heures de lever/coucher/passage) du Soleil et de la Lune, de planètes, de satellites naturels, d'astéroïdes, de comètes, d'étoiles brillantes ; des données pour l'observation de la surface du Soleil, de la Lune, et des planètes ; des cartes du ciel ainsi qu'une liste de constellations et de galaxies ; des prédictions des phénomènes astronomiques : occultation par la Lune, occultation stellaires par des astéroïdes et appulses, éclipses de Soleil et de la Lune; la liste et les coordonnées des observatoires astronomiques les plus connus ; et enfin un cahier th

  4. Vivre et survivre au bord des villes

    Directory of Open Access Journals (Sweden)

    Michel Péraldi

    1996-04-01

    Full Text Available De quels revenus vivent, ou plutôt survivent, les populations des quartiers dits défavorisés ? Telle est, malgré son apparente banalité, la question qui initie aujourd'hui une partie de nos recherches. Question banale en effet puisque les médias et le débat politique nous donnent une réponse sans appel, statistiquement fiable : dans ces univers sociaux où se croisent des communautés issues des plus récentes migrations et les fractions les plus fragiles économiquement des classes populaires fr...

  5. La compaction des sols agricoles en Wallonie

    OpenAIRE

    Destain, Marie-France

    2014-01-01

    Dans nos pays industrialisés, l’agriculture fait appel à des machines de plus en plus lourdes. Lorsque des charges élevées sont appliquées sur des sols sensibles, une compaction du sol peut se produire conduisant à des diminutions de rendements suite aux difficultés que rencontrent les racines pour prélever l’eau et les nutriments et à la perturbation de l’activité de la pédofaune. Au niveau environnemental, du fait de la compaction, l’infiltration de l’eau dans le sol est réduite, princip...

  6. Examen quinquennal 2010 : confirmation de la dérive de nos salaires

    CERN Multimedia

    STAFF ASSOCIATION

    2010-01-01

    Examen quinquennal 2010 : confirmation de la dérive de nos salaires Un examen général de nos conditions financières et sociales a lieu tous les cinq ans : « l’examen quinquennal », dont l’annexe A1 des Statut et Règlement du personnel décrit les principes et la procédure. L’objet de l’examen quinquennal est d’assurer que les conditions financières et sociales offertes par l’Organisation permettent à celle-ci d’engager, dans tous ses Etats membres, et de retenir en son sein les titulaires de la plus haute compétence et de la plus grande intégrité nécessaires à l’exécution de sa mission. L’examen quinquennal inclut, à titre obligatoire, les traitements de base (les salaires de base des titulaires, les mens...

  7. EFFET DES TRAITEMENTS THERMIQUES SUR LA REACTION ENTRE DES COUCHES MINCES DE TITANE ET DES SUBSTRATS EN ACIER

    Directory of Open Access Journals (Sweden)

    D Slimani

    2015-06-01

    Full Text Available Des couches minces du titane pur ont été déposées avec la méthode de pulvérisation cathodique sur des substrats en acier, type FF80 K-1 contenants ~1% mass. en carbone. La réaction entre les deux parties du système substrat-couche mince est activée avec des traitements thermiques sous vide dans l’intervalle de températures de 400 à900°Cpendant 30 minutes. Les Spectres de diffraction de rayons x confirment l’inter- diffusion des éléments  chimiques du système résultants la formation et la croissance des nouvelles phases en particulier le carbure binaire TiC ayant des caractéristiques thermomécaniques importantes. L’analyse morphologique des échantillons traités  avec le microscope électronique à balayage (MEB montre l’augmentation du flux de diffusion atomique avec la température de recuit, notamment la diffusion du manganèse et du fer vers la surface libre des échantillons aux températures élevées provoquant la dégradation des propriétés mécaniques des revêtements contrairement au premiers stades d’interaction où on a obtenu des bonnes valeurs de la microdureté.

  8. Economic Functions Proposal of Urgency Prioritization of Investment Projects of Operated Railway Bridges

    Directory of Open Access Journals (Sweden)

    Pitoňák Martin

    2014-12-01

    Full Text Available The main objective of the article is to describe the proposals of economic functions within the prioritization of urgency investments of operated railway bridges within a comprehensive evaluation of existing bridges. The purpose of the paper is a comprehensive assessment of existing bridges and to define determinants and determinants of decision-making and designing a mechanism of decision-making procedures of prioritized infrastructure measures in the form of repairs and reconstructions of bridges resulting from the records of supervising activities based not only on technical but also economic aspects to the railway infrastructure manager.

  9. Guidelines for nuclear power plant safety issue prioritization information development. Supplement 4

    Energy Technology Data Exchange (ETDEWEB)

    Tabatabai, A.S.; Fecht, B.A.; Powers, T.B.; Bickford, W.E.; Andrews, W.B.; Gallucci, R.H.V.; Bian, S.H.; Daling, P.M.; Eschbach, E.J.; Allen, C.H.

    1986-07-01

    This is the fifth in a series of reports to document the use of a methodology developed by the Pacific Northwest Laboratory to calculate, for prioritization purposes, the risk, dose and cost impacts of implementing resolutions to reactor safety issues (NUREG/CR-2800, Andrews et al. 1983). This report contains results of issue-specific analyses for 23 issues. Each issue was considered within the constraints of available information as of winter 1986, and two staff-weeks of labor. The results are referenced, as one consideration in setting priorities for reactor safety issues, in NUREG-0933, ''A Prioritization of Generic Safety Issues.''

  10. Guidelines for nuclear power plant safety issue prioritization information development. Supplement 2

    Energy Technology Data Exchange (ETDEWEB)

    Andrews, W.B.; Gallucci, R.H.V.; Konzek, G.J.; Heaberlin, S.W.; Fecht, B.A.; Allen, C.H.; Allen, R.D.; Bickford, W.E., Carbaugh, E.H.; Lewis, J.R.

    1983-12-01

    This is the third in a series of reports to document the use of a methodology developed by the Pacific Northwest Laboratory to calculate, for prioritization purposes, the risk, dose and cost impacts of implementing resolutions to reactor safety issues (NUREG/CR-2800, Andrews et al. 1983). This report contains results of issue-specific analyses for 31 issues. Each issue was considered within the constraints of available information as of summer 1983, and two staff-weeks of labor. The results are referenced, as one consideration in setting priorities for reactor safety issues, in NUREG-0933, A Prioritization of Generic Safety Issues.

  11. MetaRanker 2.0: a web server for prioritization of genetic variation data.

    Science.gov (United States)

    Pers, Tune H; Dworzyński, Piotr; Thomas, Cecilia Engel; Lage, Kasper; Brunak, Søren

    2013-07-01

    MetaRanker 2.0 is a web server for prioritization of common and rare frequency genetic variation data. Based on heterogeneous data sets including genetic association data, protein-protein interactions, large-scale text-mining data, copy number variation data and gene expression experiments, MetaRanker 2.0 prioritizes the protein-coding part of the human genome to shortlist candidate genes for targeted follow-up studies. MetaRanker 2.0 is made freely available at www.cbs.dtu.dk/services/MetaRanker-2.0.

  12. A Hybrid Model Predictive Control for Handling Infeasibility and Constraint Prioritization

    Institute of Scientific and Technical Information of China (English)

    王宇红; 黄德先; 金以慧

    2005-01-01

    A hybrid approach using MLD (mixed logical dynamical) framework to handle infeasibility and constraint prioritization issues in MPC (model predictive control) based on input-output model is introduced. By expressing constraint priorities as propositional logics and by transforming the propositional logics into inequalities,the infeasibility and constraint prioritization issues are solved in the MPC. Constraints with higher priorities are met first, and then these with lower priorities are satisfied as much as possible. This new approach is illustrated in the control of a heavy oil fractionator-Shell column. The overall control performance has been significantly improved through the infeasibility and control priorities handling.

  13. MetaRanker 2.0: a web server for prioritization of genetic variation data

    DEFF Research Database (Denmark)

    Pers, Tune Hannes; Dworzynski, Piotr; Thomas, Cecilia Engel;

    2013-01-01

    MetaRanker 2.0 is a web server for prioritization of common and rare frequency genetic variation data. Based on heterogeneous data sets including genetic association data, protein–protein interactions, large-scale text-mining data, copy number variation data and gene expression experiments, Meta......Ranker 2.0 prioritizes the protein-coding part of the human genome to shortlist candidate genes for targeted follow-up studies. MetaRanker 2.0 is made freely available at www.cbs.dtu.dk/services/MetaRanker-2.0....

  14. Risk-based prioritization of the Idaho National Engineering Laboratory Environmental Programs

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, R.G. [Los Alamos National Lab., NM (United States); Merkhofer, M.W.; Voth, M. [Applied Decision Analysis, Inc., Menlo Park, CA (United States); Sire, D. [Idaho National Engineering Lab., Idaho Falls, ID (United States)

    1995-03-01

    This paper describes an application of a formal prioritization system to help the Idaho National Engineering Laboratory (INEL) allocate funds for environmental projects. The system, known as the Laboratory Integration and Prioritization System (LIPS), was jointly developed by Los Alamos National Laboratory (LANL), Lawrence Livermore National Laboratory (LLNL), Sandia National Laboratories (SNL), and the US Department of Energy (DOE). LIPS is based on a formal approach for multi-criteria decision-making known as multiattribute utility analysis. The system is designed to provide a logical, practical, and equitable means for estimating and comparing the benefits to be obtained from funding project work.

  15. PINTA: a web server for network-based gene prioritization from expression data

    DEFF Research Database (Denmark)

    Nitsch, Daniela; Tranchevent, Léon-Charles; Goncalves, Joana P.

    2011-01-01

    network. Our strategy is meant for biological and medical researchers aiming at identifying novel disease genes using disease specific expression data. PINTA supports both candidate gene prioritization (starting from a user defined set of candidate genes) as well as genome-wide gene prioritization...... and is available for five species (human, mouse, rat, worm and yeast). As input data, PINTA only requires disease specific expression data, whereas various platforms (e.g. Affymetrix) are supported. As a result, PINTA computes a gene ranking and presents the results as a table that can easily be browsed...

  16. Guidelines for nuclear power plant safety issue prioritization information development. Supplement 5

    Energy Technology Data Exchange (ETDEWEB)

    Daling, P.M.; Lavender, J.C. [Pacific Northwest National Lab., Richland, WA (United States)

    1996-07-01

    This is the sixth in a series of reports to document the development and use of a methodology developed by the Pacific Northwest Laboratory (PNL) to calculate, for prioritization purposes, the risk, dose, and cost impacts of implementing potential resolutions to reactor safety issues (see NUREG/CR-2800, Andrews, et al., 1983). This report contains the results of issue-specific analyses for 34 generic issues. Each issue was considered within the constraints of available information at the time the issues were examined and approximately 2 staff-weeks of labor. The results are referenced as one consideration in NUREG-0933, A Prioritization of Generic Safety Issues (Emrit, et al., 1983).

  17. Transport quantique dans des nanostructures

    Science.gov (United States)

    Naud, C.

    2002-09-01

    structure des oscillations de conductance en fonction du flux du champ magnétique de période h/e dont l'amplitude est beaucoup plus importante que celle mesurée sur un réseau carré de même dimension. Cette différence constitue une signature d'un effet de localisation induit par le champ magnétique sur la topologie mathcal{T}3. Pour des valeurs spécifiques du champ magnétique, du fait des interférences destructives Aharonov-Bohm, la propagation des fonctions d'ondes est limitée à un ensemble fini de cellule du réseau appelé cage. De la dépendance en température des oscillations de période h/e mesurées sur le réseau mathcal{T}3 nous avons tiré une longueur caractéristique qui peut être rattachée au périmètre des cages. Un phénomène inattendu fut l'observation, pour des champs magnétiques plus importants, d'un doublement de fréquence des oscillations. Ces oscillations de période h/2e pouvant avoir une amplitude supérieure aux oscillations de période h/e, une interprétation en terme d'harmonique n'est pas possible. Enfin, l'influence de la largeur électrique des fils constituant le réseau et donc celle du nombre de canaux par brin a été étudiée en réalisant des grilles électrostatique. Les variations de l'amplitude des signaux en h/e et h/2e en fonction de la tension de grille ont été mesurés.

  18. Impact de la preparation des anodes crues et des conditions de cuisson sur la fissuration dans des anodes denses

    Science.gov (United States)

    Amrani, Salah

    La fabrication de l'aluminium est realisee dans une cellule d'electrolyse, et cette operation utilise des anodes en carbone. L'evaluation de la qualite de ces anodes reste indispensable avant leur utilisation. La presence des fissures dans les anodes provoque une perturbation du procede l'electrolyse et une diminution de sa performance. Ce projet a ete entrepris pour determiner l'impact des differents parametres de procedes de fabrication des anodes sur la fissuration des anodes denses. Ces parametres incluent ceux de la fabrication des anodes crues, des proprietes des matieres premieres et de la cuisson. Une recherche bibliographique a ete effectuee sur tous les aspects de la fissuration des anodes en carbone pour compiler les travaux anterieurs. Une methodologie detaillee a ete mise au point pour faciliter le deroulement des travaux et atteindre les objectifs vises. La majorite de ce document est reservee pour la discussion des resultats obtenus au laboratoire de l'UQAC et au niveau industriel. Concernant les etudes realisees a l'UQAC, une partie des travaux experimentaux est reservee a la recherche des differents mecanismes de fissuration dans les anodes denses utilisees dans l'industrie d'aluminium. L'approche etait d'abord basee sur la caracterisation qualitative du mecanisme de la fissuration en surface et en profondeur. Puis, une caracterisation quantitative a ete realisee pour la determination de la distribution de la largeur de la fissure sur toute sa longueur, ainsi que le pourcentage de sa surface par rapport a la surface totale de l'echantillon. Cette etude a ete realisee par le biais de la technique d'analyse d'image utilisee pour caracteriser la fissuration d'un echantillon d'anode cuite. L'analyse surfacique et en profondeur de cet echantillon a permis de voir clairement la formation des fissures sur une grande partie de la surface analysee. L'autre partie des travaux est basee sur la caracterisation des defauts dans des echantillons d'anodes crues

  19. Using XML to encode TMA DES metadata

    Directory of Open Access Journals (Sweden)

    Oliver Lyttleton

    2011-01-01

    Full Text Available Background: The Tissue Microarray Data Exchange Specification (TMA DES is an XML specification for encoding TMA experiment data. While TMA DES data is encoded in XML, the files that describe its syntax, structure, and semantics are not. The DTD format is used to describe the syntax and structure of TMA DES, and the ISO 11179 format is used to define the semantics of TMA DES. However, XML Schema can be used in place of DTDs, and another XML encoded format, RDF, can be used in place of ISO 11179. Encoding all TMA DES data and metadata in XML would simplify the development and usage of programs which validate and parse TMA DES data. XML Schema has advantages over DTDs such as support for data types, and a more powerful means of specifying constraints on data values. An advantage of RDF encoded in XML over ISO 11179 is that XML defines rules for encoding data, whereas ISO 11179 does not. Materials and Methods: We created an XML Schema version of the TMA DES DTD. We wrote a program that converted ISO 11179 definitions to RDF encoded in XML, and used it to convert the TMA DES ISO 11179 definitions to RDF. Results: We validated a sample TMA DES XML file that was supplied with the publication that originally specified TMA DES using our XML Schema. We successfully validated the RDF produced by our ISO 11179 converter with the W3C RDF validation service. Conclusions: All TMA DES data could be encoded using XML, which simplifies its processing. XML Schema allows datatypes and valid value ranges to be specified for CDEs, which enables a wider range of error checking to be performed using XML Schemas than could be performed using DTDs.

  20. Using XML to encode TMA DES metadata.

    Science.gov (United States)

    Lyttleton, Oliver; Wright, Alexander; Treanor, Darren; Lewis, Paul

    2011-01-01

    The Tissue Microarray Data Exchange Specification (TMA DES) is an XML specification for encoding TMA experiment data. While TMA DES data is encoded in XML, the files that describe its syntax, structure, and semantics are not. The DTD format is used to describe the syntax and structure of TMA DES, and the ISO 11179 format is used to define the semantics of TMA DES. However, XML Schema can be used in place of DTDs, and another XML encoded format, RDF, can be used in place of ISO 11179. Encoding all TMA DES data and metadata in XML would simplify the development and usage of programs which validate and parse TMA DES data. XML Schema has advantages over DTDs such as support for data types, and a more powerful means of specifying constraints on data values. An advantage of RDF encoded in XML over ISO 11179 is that XML defines rules for encoding data, whereas ISO 11179 does not. We created an XML Schema version of the TMA DES DTD. We wrote a program that converted ISO 11179 definitions to RDF encoded in XML, and used it to convert the TMA DES ISO 11179 definitions to RDF. We validated a sample TMA DES XML file that was supplied with the publication that originally specified TMA DES using our XML Schema. We successfully validated the RDF produced by our ISO 11179 converter with the W3C RDF validation service. All TMA DES data could be encoded using XML, which simplifies its processing. XML Schema allows datatypes and valid value ranges to be specified for CDEs, which enables a wider range of error checking to be performed using XML Schemas than could be performed using DTDs.

  1. APPRENTISSAGE DES LANGUES AUTOUR DES MéDIATIONS ARTISTIQUES (ART-THéRAPIE DE COLORIAGE)

    OpenAIRE

    KONEVA (HAAN) MARINA GENNADIEVNA

    2014-01-01

    L’article est consacré aux problématiques liées à l’acquisition des compétences lexicales à partir des textes littéraires et des œuvres de coloriage de l’art-thérapie. En s’appuyant sur l’analyse psycholinguistique du fonctionnement des émotions dans la production des images mentales des mots, on propose une méthode pédagogique, basée sur la synergie des émotions, sensations et cognition. La méthode peut être utilisée dans le cadre institutionnel (collège, lycée, université), ainsi que pour l...

  2. Vers une meilleure comprehension des savoirs disciplinaires et curriculaires des enseignants ou Ie paradigme retrouve

    Directory of Open Access Journals (Sweden)

    Stephane Martineau

    1999-01-01

    Full Text Available eet article se veut essentieUement un travail de synthese sous la forme d 'une breve revue de litterature au sujet des savoirs disciplinaires et curriculaires en enseignement. Plus specifiquement, il vise a determiner queUes sont les principales conclusions qui se degagent de la lecture des recherches empiriques sur les savoirs disciplinaires et curriculaires des enseignants des ordres d'enseignement primaire et secondaire. Il propose donc une classification des differentes dimensions constitutives du rapport entre les savoirs disciplinaires et curriculaires et la pratique enseignante. Les resultats mis au jour permettent d 'une part, d'identifier les facteurs qui entrainent des differences dans les connaissances disciplinaires et curriculaires des enseignants et d'autre part, de mieux saisir comment ces connaissances de l'enseignant peuvent influencer en retour sa pratique.

  3. Acidification des eaux de source et saturnisme dans le Massif vosgien.

    OpenAIRE

    1999-01-01

    Les recherches menées à  l'occasion du programme DEFORPA ont montré que les dépôts acides et la sylviculture avaient directement contribué à une acidification des sols et des eaux de surface du Massif vosgien. L'étude de la variation de l'acidité des eaux de source depuis 30 ans a confirmé une acidification progressive de l'eau captée sur les roches les plus pauvres, comme le grès vosgien. Nous avons expérimentalement vérifié que cette acidification a considérablement augmenté la teneur en pl...

  4. Joint Measurement of Lensing-Galaxy Correlations Using SPT and DES SV Data

    CERN Document Server

    Baxter, E J; Giannantonio, T; Dodelson, S; Jain, B; Huterer, D; Bleem, L E; Crawford, T M; Efstathiou, G; Fosalba, P; Kirk, D; Kwan, J; Sánchez, C; Story, K T; Troxel, M A; Abbott, T M C; Abdalla, F B; Armstrong, R; Benoit-Lévy, A; Benson, B A; Bernstein, G M; Bernstein, R A; Bertin, E; Brooks, D; Carlstrom, J E; Rosell, A Carnero; Kind, M Carrasco; Carretero, J; Chown, R; Crocce, M; Cunha, C E; D'Andrea, C B; da Costa, L N; Desai, S; Diehl, H T; Dietrich, J P; Doel, P; Evrard, A E; Neto, A Fausti; Flaugher, B; Frieman, J; Gruen, D; Gruendl, R A; Gutierrez, G; de Haan, T; Holder, G P; Honscheid, K; Hou, Z; James, D J; Kuehn, K; Kuropatkin, N; Lima, M; March, M; Marshall, J L; Martini, P; Melchior, P; Miller, C J; Miquel, R; Mohr, J J; Nord, B; Omori, Y; Plazas, A A; Reichardt, C L; Romer, A K; Rykoff, E S; Sanchez, E; Sevilla-Noarbe, I; Sheldon, E; Smith, R C; Soares-Santos, M; Sobreira, F; Suchyta, E; Stark, A A; Swanson, M E C; Tarle, G; Thomas, D; Walker, A R; Wechsler, R H

    2016-01-01

    We measure the correlation of galaxy lensing and cosmic microwave background lensing with a set of galaxies expected to trace the matter density field. The measurements are performed using pre-survey Dark Energy Survey (DES) Science Verification optical imaging data and millimeter-wave data from the 2500 square degree South Pole Telescope Sunyaev-Zel'dovich (SPT-SZ) survey. The two lensing-galaxy correlations are jointly fit to extract constraints on cosmological parameters, constraints on the redshift distribution of the lens galaxies, and constraints on the absolute shear calibration of DES galaxy lensing measurements. We show that an attractive feature of these fits is that they are fairly insensitive to the clustering bias of the galaxies used as matter tracers. The measurement presented in this work confirms that DES and SPT data are consistent with each other and with the currently favored $\\Lambda$CDM cosmological model. It also demonstrates that joint lensing-galaxy correlation measurement considered ...

  5. Effectiveness of a risk-based visitor-prioritizing system at a sexually transmitted infection outpatient clinic

    NARCIS (Netherlands)

    Heijman, T.L.J.; van der Bij, A.K.; de Vries, H.J.C.; van Leent, E.J.M.; Thiesbrummel, H.F.J.; Fennema, H.S.A.

    2007-01-01

    Objective: The objective of this study was to study the efficacy/effectiveness of a risk-based visitor-prioritizing system at a sexually transmitted infection (STI) clinic aimed to improve screening capacity by providing tailored service. Study Design: In April 2004, a prioritizing system was implem

  6. GENOMIQUE ET LIPIDES Génomique et métabolisme des lipides des plantes

    Directory of Open Access Journals (Sweden)

    Delseny Michel

    2002-03-01

    Full Text Available Il existe dans les bases de données publiques une énorme quantité de séquences d’ADN dérivées de plantes, et notamment la séquence complète du génome d’Arabidopsis thaliana, une plante modèle pour les oléagineux, proche parente du colza. Ces données constituent une ressource importante non seulement pour la compréhension de métabolisme lipidique et de sa régulation, mais aussi pour la sélection et le développement de variétés nouvelles d’oléagineux produisant davantage d’huiles ou des huiles de composition nouvelle. Cette abondance de séquences peut être exploitée, en utilisant les recherches d’homologies, pour identifier les gènes, pour obtenir des informations sur leur fonction, comme pour repérer des gènes candidats codant des fonctions nouvelles. L’analyse de ces bases de données a révélé que la majeure partie des gènes codant des enzymes impliquées dans le métabolisme lipidique appartient à des petites familles multigéniques, reflétant la diversification des fonctions des isoformes. Une analyse du catalogue des ADNc séquencés en aveugle reflète les niveaux d’expression des différents gènes et fournit un aperçu des régulations des flux au travers des voies métaboliques conduisant à la biosynthèse des lipides de réserve. La disponibilité de mutants et de lignées transgéniques d’Arabidopsis et le développement de puces à ADN qui permettent l’analyse simultanée de plusieurs milliers de gènes conduiront à une meilleure compréhension des facteurs qui régulent le métabolisme des huiles dans les graines. Une telle connaissance facilitera la manipulation de la composition des huiles et des quantités produites dans les graines.

  7. RiskREP: Risk-Based Security Requirements Elicitation and Prioritization (extended version)

    NARCIS (Netherlands)

    Herrmann, Andrea; Morali, A.

    2010-01-01

    Today, companies are required to be in control of the security of their IT assets. This is especially challenging in the presence of limited budgets and conflicting requirements. Here, we present Risk-Based Requirements Elicitation and Prioritization (RiskREP), a method for managing IT security

  8. Identification and Prioritization of Hazardous Road Locations by Segmentation and Data Envelopment Analysis Approach

    Directory of Open Access Journals (Sweden)

    Aliasghar Sadeghi

    2013-04-01

    Full Text Available The aim of the present study is the representation of a method to identify and prioritize accident-prone sections (APSs based upon efficiency concept to emphasize accidents with regard to traffic, geometric and environmental circumstances of road which can consider the interaction of accidents as well as their casual factors. This study incorporates the segmentation procedure into data envelopment analysis (DEA technique which has no requirement of distribution function and special assumptions, unlike the regression models. A case study has been done on 144.4km length of Iran roads to describe the approach. Eleven accident-prone sections were identified among 154 sections obtained from the segmentation process and their prioritization was made based on the inefficiency values coming from DEA method. The comparisons demonstrated that the frequency and severity of accidents would not be only considered as the main factors for black-spots identification but proper rating can be possible by obtaining inefficiency values from this method for the road sections. This approach could applicably offer decision-making units for identifying accident-prone sections and their prioritizations. Also, it can be used to prioritize intersections, roundabouts or the total roads of the safety organization domain.

  9. Enhancing the prioritization of disease-causing genes through tissue specific protein interaction networks.

    Directory of Open Access Journals (Sweden)

    Oded Magger

    Full Text Available The prioritization of candidate disease-causing genes is a fundamental challenge in the post-genomic era. Current state of the art methods exploit a protein-protein interaction (PPI network for this task. They are based on the observation that genes causing phenotypically-similar diseases tend to lie close to one another in a PPI network. However, to date, these methods have used a static picture of human PPIs, while diseases impact specific tissues in which the PPI networks may be dramatically different. Here, for the first time, we perform a large-scale assessment of the contribution of tissue-specific information to gene prioritization. By integrating tissue-specific gene expression data with PPI information, we construct tissue-specific PPI networks for 60 tissues and investigate their prioritization power. We find that tissue-specific PPI networks considerably improve the prioritization results compared to those obtained using a generic PPI network. Furthermore, they allow predicting novel disease-tissue associations, pointing to sub-clinical tissue effects that may escape early detection.

  10. Department of Defense and Security Cooperation: Improving Prioritization, Authorities, and Evaluations

    Science.gov (United States)

    2016-03-09

    McNerney, Stuart E. Johnson, Stephanie Pezard, David Stebbins , Renanah Miles, Angela O’Mahony, Chaoling Feng, Tim Oliver, Defense Institution Building... line of work. Today, I will focus on three questions. First, how does the Department of Defense (DoD) prioritize its security cooperation

  11. Prioritizing marine spatial planning efforts with the assets, threats and solvability framework

    Science.gov (United States)

    The application of marine zoning and spatial planning methods has seen a worldwide increase to stem unsustainable use of coastal seas. However, prioritizing marine regions for focused management efforts and protection can be a difficult process. Uncertainties from the provision o...

  12. A Toxicological Framework for the Prioritization of Children's Safe Product Act Data.

    Science.gov (United States)

    Smith, Marissa N; Grice, Joshua; Cullen, Alison; Faustman, Elaine M

    2016-04-19

    In response to concerns over hazardous chemicals in children's products, Washington State passed the Children's Safe Product Act (CSPA). CSPA requires manufacturers to report the concentration of 66 chemicals in children's products. We describe a framework for the toxicological prioritization of the ten chemical groups most frequently reported under CSPA. The framework scores lifestage, exposure duration, primary, secondary and tertiary exposure routes, toxicokinetics and chemical properties to calculate an exposure score. Four toxicological endpoints were assessed based on curated national and international databases: reproductive and developmental toxicity, endocrine disruption, neurotoxicity and carcinogenicity. A total priority index was calculated from the product of the toxicity and exposure scores. The three highest priority chemicals were formaldehyde, dibutyl phthalate and styrene. Elements of the framework were compared to existing prioritization tools, such as the United States Environmental Protection Agency's (EPA) ExpoCast and Toxicological Prioritization Index (ToxPi). The CSPA framework allowed us to examine toxicity and exposure pathways in a lifestage-specific manner, providing a relatively high throughput approach to prioritizing hazardous chemicals found in children's products.

  13. Prioritizing quality over profit: Value trade-offs within architect-client relations

    NARCIS (Netherlands)

    Bos-De Vos, M.; Volker, L.; Wamelink, J.W.F.

    2015-01-01

    Architectural service delivery involves a complex system of economic and quality related value dimensions, which are mutually dependent and prioritized differently by actors. Responding to professional logics as well as organizational logics, value creation goals of architects and clients are multid

  14. Citizen participation in patient prioritization policy decisions: an empirical and experimental study on patients' characteristics.

    Science.gov (United States)

    Diederich, Adele; Swait, Joffre; Wirsik, Norman

    2012-01-01

    Health systems worldwide are grappling with the need to control costs to maintain system viability. With the combination of worsening economic conditions, an aging population and reductions in tax revenues, the pressures to make structural changes are expected to continue growing. Common cost control mechanisms, e.g. curtailment of patient access and treatment prioritization, are likely to be adversely viewed by citizens. It seems therefore wise to include them in the decision making processes that lead up to policy changes. In the context of a multilevel iterative mixed-method design a quantitative survey representative of the German population (N = 2031) was conducted to probe the acceptance of priority setting in medicine and to explore the practicability of direct public involvement. Here we focus on preferences for patients' characteristics (medical aspects, lifestyle and socio-economic status) as possible criteria for prioritizing medical services. A questionnaire with closed response options was fielded to gain insight into attitudes toward broad prioritization criteria of patient groups. Furthermore, a discrete choice experiment was used as a rigorous approach to investigate citizens' preferences toward specific criteria level in context of other criteria. Both the questionnaire and the discrete choice experiment were performed with the same sample. The citizens' own health and social situation are included as explanatory variables. Data were evaluated using corresponding analysis, contingency analysis, logistic regression and a multinomial exploded logit model. The results show that some medical criteria are highly accepted for prioritizing patients whereas socio-economic criteria are rejected.

  15. 13 CFR 107.1540 - Distributions by Licensee-Prioritized Payments and Adjustments.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Distributions by Licensee-Prioritized Payments and Adjustments. 107.1540 Section 107.1540 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS INVESTMENT COMPANIES SBA Financial Assistance for Licensees...

  16. Prioritizing plant defence over growth through WRKY regulation facilitates infestation by non-target herbivores

    Science.gov (United States)

    Li, Ran; Zhang, Jin; Li, Jiancai; Zhou, Guoxin; Wang, Qi; Bian, Wenbo; Erb, Matthias; Lou, Yonggen

    2015-01-01

    Plants generally respond to herbivore attack by increasing resistance and decreasing growth. This prioritization is achieved through the regulation of phytohormonal signaling networks. However, it remains unknown how this prioritization affects resistance against non-target herbivores. In this study, we identify WRKY70 as a specific herbivore-induced, mitogen-activated protein kinase-regulated rice transcription factor that physically interacts with W-box motifs and prioritizes defence over growth by positively regulating jasmonic acid (JA) and negatively regulating gibberellin (GA) biosynthesis upon attack by the chewing herbivore Chilo suppressalis. WRKY70-dependent JA biosynthesis is required for proteinase inhibitor activation and resistance against C. suppressalis. In contrast, WRKY70 induction increases plant susceptibility against the rice brown planthopper Nilaparvata lugens. Experiments with GA-deficient rice lines identify WRKY70-dependent GA signaling as the causal factor in N. lugens susceptibility. Our study shows that prioritizing defence over growth leads to a significant resistance trade-off with important implications for the evolution and agricultural exploitation of plant immunity. DOI: http://dx.doi.org/10.7554/eLife.04805.001 PMID:26083713

  17. Multigranular Uncertain Linguistic Prioritized Aggregation Operators and Their Application to Multiple Criteria Group Decision Making

    Directory of Open Access Journals (Sweden)

    Ding-Hong Peng

    2013-01-01

    Full Text Available We investigate multiple criteria group decision-making problems in which there are priority relationships between the decision elements (criteria and experts, and decision information provided by decision makers takes the form of multigranular uncertain linguistic information. Firstly, some operational laws and possibility degree of multi-granular uncertain linguistic variables are introduced. Then, some new linguistic aggregation operators based on the prioritized aggregation operator, such as the multigranular uncertain linguistic prioritized weighted average (MULPWA operator and the multigranular uncertain linguistic prioritized ordered weighted average (MULPOWA operator, are developed and their desirable properties are studied. The prominent characteristics of these proposed operators are that they can aggregate directly the uncertain linguistic variables whose values form the linguistic term sets with different granularities and convey the prioritization phenomenon among the aggregated arguments. Furthermore, based on the MULPWA and MULPOWA operators, an approach to deal with multiple criteria group decision-making problems under multi-granular uncertain linguistic environments is developed. Finally, a practical example is provided to illustrate the multiple criteria group decision-making process.

  18. Prioritizing plant defence over growth through WRKY regulation facilitates infestation by non-target herbivores.

    Science.gov (United States)

    Li, Ran; Zhang, Jin; Li, Jiancai; Zhou, Guoxin; Wang, Qi; Bian, Wenbo; Erb, Matthias; Lou, Yonggen

    2015-06-17

    Plants generally respond to herbivore attack by increasing resistance and decreasing growth. This prioritization is achieved through the regulation of phytohormonal signaling networks. However, it remains unknown how this prioritization affects resistance against non-target herbivores. In this study, we identify WRKY70 as a specific herbivore-induced, mitogen-activated protein kinase-regulated rice transcription factor that physically interacts with W-box motives and prioritizes defence over growth by positively regulating jasmonic acid (JA) and negatively regulating gibberellin (GA) biosynthesis upon attack by the chewing herbivore Chilo suppressalis. WRKY70-dependent JA biosynthesis is required for proteinase inhibitor activation and resistance against C. suppressalis. In contrast, WRKY70 induction increases plant susceptibility against the rice brown planthopper Nilaparvata lugens. Experiments with GA-deficient rice lines identify WRKY70-dependent GA signaling as the causal factor in N. lugens susceptibility. Our study shows that prioritizing defence over growth leads to a significant resistance trade-off with important implications for the evolution and agricultural exploitation of plant immunity.

  19. Information matching the content of visual working memory is prioritized for conscious access.

    NARCIS (Netherlands)

    Gayet, S.; Paffen, C.L.E.; Stigchel, S. van der

    2013-01-01

    Visual working memory (VWM) is used to retain relevant information for imminent goal-directed behavior. In the experiments reported here, we found that VWM helps to prioritize relevant information that is not yet available for conscious experience. In five experiments, we demonstrated that informati

  20. Situation of Iron Deficiency and Its Management Prioritizing Dietary Intervention in Nepal

    DEFF Research Database (Denmark)

    Adhikari, BK; Koirala, U; Lama, STA

    2012-01-01

    Background Control of iron deficiency disorders is prioritized in the nutrition policies of Nepal. The situation is still threatening the public health in both rural and urban areas. Objective There are limited reviews on the iron deficiency situation in Nepal. This study was undertaken to find o...

  1. Prioritizing preferable locations for increasing urban tree canopy in New York City

    Science.gov (United States)

    Dexter Locke; J. Morgan Grove; Jacqueline W.T. Lu; Austin Troy; Jarlath P.M. O' Neil-Dunne; Brian. Beck

    2010-01-01

    This paper presents a set of Geographic Information System (GIS) methods for identifying and prioritizing tree planting sites in urban environments. It uses an analytical approach created by a University of Vermont service-learning class called "GIS Analysis of New York City's Ecology" that was designed to provide research support to the MillionTreesNYC...

  2. Discursively Prioritizing Stakeholder Interests: An Inquiry into Habermas’s Distinction between Morality and Ethics

    NARCIS (Netherlands)

    Linden, B.S. van der

    2012-01-01

    Contributions to stakeholder theory often do not systematically deal with the prioritization of stakeholder interests. An exception to this is Reed’s Habermasian approach to stakeholder management. Central to Reed’s discursive approach is Habermas’s distinction between morality and ethics. Many auth

  3. Prioritizing Active Learning: An Exploration of Gateway Courses in Political Science

    Science.gov (United States)

    Archer, Candace C.; Miller, Melissa K.

    2011-01-01

    Prior research in political science and other disciplines demonstrates the pedagogical and practical benefits of active learning. Less is known, however, about the extent to which active learning is used in political science classrooms. This study assesses the prioritization of active learning in "gateway" political science courses, paying…

  4. Using County-Level Public Health Data to Prioritize Medical Education Topics

    Science.gov (United States)

    Sumner, Walton, II; Schootman, Mario; Asaro, Philip; Yan, Yan; Hagen, Michael D.

    2008-01-01

    Introduction: Medical education topics might be locally prioritized using public health data on health outcomes and risk factors unrelated to quality of care. Methods: The Missouri Information for Community Assessment (MICA) supplied preventable hospitalization rates (PHRs) for asthma, chronic obstructive pulmonary disease (COPD), diabetes, heart…

  5. Temporal Expectations Guide Dynamic Prioritization in Visual Working Memory through Attenuated α Oscillations.

    Science.gov (United States)

    van Ede, Freek; Niklaus, Marcel; Nobre, Anna C

    2017-01-11

    Although working memory is generally considered a highly dynamic mnemonic store, popular laboratory tasks used to understand its psychological and neural mechanisms (such as change detection and continuous reproduction) often remain relatively "static," involving the retention of a set number of items throughout a shared delay interval. In the current study, we investigated visual working memory in a more dynamic setting, and assessed the following: (1) whether internally guided temporal expectations can dynamically and reversibly prioritize individual mnemonic items at specific times at which they are deemed most relevant; and (2) the neural substrates that support such dynamic prioritization. Participants encoded two differently colored oriented bars into visual working memory to retrieve the orientation of one bar with a precision judgment when subsequently probed. To test for the flexible temporal control to access and retrieve remembered items, we manipulated the probability for each of the two bars to be probed over time, and recorded EEG in healthy human volunteers. Temporal expectations had a profound influence on working memory performance, leading to faster access times as well as more accurate orientation reproductions for items that were probed at expected times. Furthermore, this dynamic prioritization was associated with the temporally specific attenuation of contralateral α (8-14 Hz) oscillations that, moreover, predicted working memory access times on a trial-by-trial basis. We conclude that attentional prioritization in working memory can be dynamically steered by internally guided temporal expectations, and is supported by the attenuation of α oscillations in task-relevant sensory brain areas.

  6. Agile Requirements Prioritization: What Happens in Practice and What Is Described in Literature

    NARCIS (Netherlands)

    Bakalova, Z.; Daneva, Maia; Herrmann, Andrea; Wieringa, Roelf J.

    [Context & motivation] Requirements (re)prioritization is an essential mechanism of agile development approaches to maximize the value for the clients and to accommodate changing requirements. Yet, in the agile Requirements Engineering (RE) literature, very little is known about how agile

  7. Bedrijfsgebonden dierziekten op schapen-, geiten- en paardenbedrijven : [inventarisatie en prioritering van de belangrijkste aandoeningen

    NARCIS (Netherlands)

    Bokma-Bakker, M.H.; Bartels, C.J.M.; Bergevoet, R.H.M.; Wolthuis-Fillerup, M.; Nodelijk, G.

    2012-01-01

    In deze rapportage is een inventarisatie en prioritering van bedrijfsgebonden aandoeningen in de schapen-, geiten- en paardensector uitgewerkt. Deze kunnen de overheid en veehouderijsectoren een handvat geven voor een nadere invulling van haar Nationale Agenda Diergezondheid en behulpzaam zijn bij h

  8. A Toxicological Framework for the Prioritization of Children’s Safe Product Act Data

    Directory of Open Access Journals (Sweden)

    Marissa N. Smith

    2016-04-01

    Full Text Available In response to concerns over hazardous chemicals in children’s products, Washington State passed the Children’s Safe Product Act (CSPA. CSPA requires manufacturers to report the concentration of 66 chemicals in children’s products. We describe a framework for the toxicological prioritization of the ten chemical groups most frequently reported under CSPA. The framework scores lifestage, exposure duration, primary, secondary and tertiary exposure routes, toxicokinetics and chemical properties to calculate an exposure score. Four toxicological endpoints were assessed based on curated national and international databases: reproductive and developmental toxicity, endocrine disruption, neurotoxicity and carcinogenicity. A total priority index was calculated from the product of the toxicity and exposure scores. The three highest priority chemicals were formaldehyde, dibutyl phthalate and styrene. Elements of the framework were compared to existing prioritization tools, such as the United States Environmental Protection Agency’s (EPA ExpoCast and Toxicological Prioritization Index (ToxPi. The CSPA framework allowed us to examine toxicity and exposure pathways in a lifestage-specific manner, providing a relatively high throughput approach to prioritizing hazardous chemicals found in children’s products.

  9. Consequences for diversity when prioritizing animals for conservation with pedigree or genomic information.

    Science.gov (United States)

    Engelsma, K A; Veerkamp, R F; Calus, M P L; Windig, J J

    2011-12-01

    Up to now, prioritization of animals for conservation has been mainly based on pedigree information; however, genomic information may improve prioritization. In this study, we used two Holstein populations to investigate the consequences for genetic diversity when animals are prioritized with optimal contributions based on pedigree or genomic data and whether consequences are different at the chromosomal level. Selection with genomic kinships resulted in a higher conserved diversity, but differences were small. Largest differences were found when few animals were prioritized and when pedigree errors were present. We found more differences at the chromosomal level, where selection based on genomic kinships resulted in a higher conserved diversity for most chromosomes, but for some chromosomes, pedigree-based selection resulted in a higher conserved diversity. To optimize conservation strategies, genomic information can help to improve the selection of animals for conservation in those situations where pedigree information is unreliable or absent or when we want to conserve diversity at specific genome regions. © 2011 Blackwell Verlag GmbH.

  10. Catégorisation aspectuelle des concepts

    Directory of Open Access Journals (Sweden)

    Karolak Stanisław

    2008-01-01

    Full Text Available (francuski Le contenu de l'article est le problème connu en aspectologie comme celui de la dépendance entre le sens lexical des verbes et l'aspect. Les contraintes qu'imposent les langues à la distribution des grammèmes d'aspect ont fait supposer qu'il existe des règles de leur co-occurrence avec les sémantèmes. Le problème est posé ici dans une perspective conceptuelle. Dans cette perspective, les verbes dont les sémantèmes ont tel ou tel aspect n'exigent pas la co-occurrence avec des grammèmes qui véhiculent le même aspect. En revanche, ils peuvent se combiner avec des grammèmes de sens aspectuel opposé pour dériver des catégories de verbes secondaires à partir des catégories primaires. On postule l'existence d'un mécanisme dérivationnel qui engendre des verbes polyaspectuels.

  11. Supply Chain et Gestion des ressources humaines

    OpenAIRE

    Nondonfaz, Robert

    2010-01-01

    Rappels de quelques exigences de la Supply Chain en matière de gestion des ressources humaines; spécificités de certains métiers : chauffeur, magasinier, acheteur, gestionnaire de stock, gestion des imprévus

  12. internationalisation et nouvelles implantations des firmes ...

    African Journals Online (AJOL)

    Administrateur

    de disparités culturelles ou dans les pratiques des affaires ou encore dans le .... plus pertinents afin d'expliquer l'évolution du modèle (cas de la distance psychique par ..... Elles constituent plutôt une lecture globale et intégrée des processus.

  13. OzDES multifibre spectroscopy for the Dark Energy Survey: first-year operation and results

    Energy Technology Data Exchange (ETDEWEB)

    Yuan, Fang; Lidman, C.; Davis, T. M.; Childress, M.; Abdalla, F. B.; Banerji, M.; Buckley-Geer, E.; Carnero Rosell, A.; Carollo, D.; Castander, F. J.; D' Andrea, C. B.; Diehl, H. T.; Cunha, C. E.; Foley, R. J.; Frieman, J.; Glazebrook, K.; Gschwend, J.; Hinton, S.; Jouvel, S.; Kessler, R.; Kim, A. G.; King, A. L.; Kuehn, K.; Kuhlmann, S.; Lewis, G. F.; Lin, H.; Martini, P.; McMahon, R. G.; Mould, J.; Nichol, R. C.; Norris, R. P.; O' Neill, C. R.; Ostrovski, F.; Papadopoulos, A.; Parkinson, D.; Reed, S.; Romer, A. K.; Rooney, P. J.; Rozo, E.; Rykoff, E. S.; Sako, M.; Scalzo, R.; Schmidt, B. P.; Scolnic, D.; Seymour, N.; Sharp, R.; Sobreira, F.; Sullivan, M.; Thomas, R. C.; Tucker, D.; Uddin, S. A.; Wechsler, R. H.; Wester, W.; Wilcox, H.; Zhang, B.; Abbott, T.; Allam, S.; Bauer, A. H.; Benoit-L?vy, A.; Bertin, E.; Brooks, D.; Burke, D. L.; Carrasco Kind, M.; Covarrubias, R.; Crocce, M.; da Costa, L. N.; DePoy, D. L.; Desai, S.; Doel, P.; Eifler, T. F.; Evrard, A. E.; Fausti Neto, A.; Flaugher, B.; Fosalba, P.; Gaztanaga, E.; Gerdes, D.; Gruen, D.; Gruendl, R. A.; Honscheid, K.; James, D.; Kuropatkin, N.; Lahav, O.; Li, T. S.; Maia, M. A. G.; Makler, M.; Marshall, J.; Miller, C. J.; Miquel, R.; Ogando, R.; Plazas, A. A.; Roodman, A.; Sanchez, E.; Scarpine, V.; Schubnell, M.; Sevilla-Noarbe, I.; Smith, R. C.; Soares-Santos, M.; Suchyta, E.; Swanson, M. E. C.; Tarle, G.; Thaler, J.; Walker, A. R.

    2015-07-29

    We present results for the first three years of OzDES, a six-year program to obtain redshifts for objects in the Dark Energy Survey (DES) supernova fields using the 2dF fibre positioner and AAOmega spectrograph on the Anglo-Australian Telescope. OzDES is a multi-object spectroscopic survey targeting multiple types of targets at multiple epochs over a multi-year baseline, and is one of the first multi-object spectroscopic surveys to dynamically include transients into the target list soon after their discovery. At the end of three years, OzDES has spectroscopically confirmed almost 100 supernovae, and has measured redshifts for 17,000 objects, including the redshifts of 2,566 supernova hosts. We examine how our ability to measure redshifts for targets of various types depends on signal-to-noise, magnitude, and exposure time, finding that our redshift success rate increases significantly at a signal-to-noise of 2 to 3 per 1-A° ngstrom bin. We also find that the change in signal-to-noise with exposure time closely matches the Poisson limit for stacked exposures as long as 10 hours.We use these results to predict the redshift yield of the full OzDES survey, as well as the potential yields of future surveys on other facilities such as 4MOST, PFS, and MSE. This work marks the first OzDES data release, comprising 15,327 redshifts. OzDES is on target to obtain over 30,000 redshifts over the six-year duration of the survey, including a yield of approximately 5,700 supernova host-galaxy redshifts.

  14. Observation and Confirmation of Six Strong Lensing Systems in The Dark Energy Survey Science Verification Data

    CERN Document Server

    Nord, B; Lin, H; Diehl, H T; Helsby, J; Kuropatkin, N; Amara, A; Collett, T; Allam, S; Caminha, G; De Bom, C; Desai, S; Dúmet-Montoya, H; Pereira, M Elidaiana da S; Finley, D A; Flaugher, B; Furlanetto, C; Gaitsch, H; Gill, M; Merritt, K W; More, A; Tucker, D; Rykoff, E S; Rozo, E; Abdalla, F B; Agnello, A; Auger, M; Brunner, R J; Kind, M Carrasco; Castander, F J; Cunha, C E; da Costa, L N; Foley, R; Gerdes, D W; Glazebrook, K; Gschwend, J; Hartley, W; Kessler, R; Lagattuta, D; Lewis, G; Maia, M A G; Makler, M; Menanteau, F; Niernberg, A; Scolnic, D; Vieira, J D; Gramillano, R; Abbott, T M C; Banerji, M; Benoit-Lévy, A; Brooks, D; Burke, D L; Capozzi, D; Rosell, A Carnero; Carretero, J; D'Andrea, C B; Dietrich, J P; Doel, P; Evrard, A E; Frieman, J; Gaztanaga, E; Gruen, D; Honscheid, K; James, D J; Kuehn, K; Li, T S; Lima, M; Marshall, J L; Martini, P; Melchior, P; Miquel, R; Neilsen, E; Nichol, R C; Ogando, R; Plazas, A A; Romer, A K; Sako, M; Sanchez, E; Scarpine, V; Schubnell, M; Sevilla-Noarbe, I; Smith, R C; Soares-Santos, M; Sobreira, F; Suchyta, E; Swanson, M E C; Tarle, G; Thaler, J; Walker, A R; Wester, W; Zhang, Y

    2015-01-01

    We report the observation and confirmation of the first group- and cluster-scale strong gravitational lensing systems found in Dark Energy Survey (DES) data. Through visual inspection of data from the Science Verification (SV) season, we identified 53 candidate systems. We then obtained spectroscopic follow-up of 21 candidates using the Gemini Multi-Object Spectrograph (GMOS) at the Gemini South telescope and the Inamori-Magellan Areal Camera and Spectrograph (IMACS) at the Magellan/Baade telescope. With this follow-up, we confirmed six candidates as gravitational lenses: Three of the systems are newly discovered, and the remaining three were previously known. Of the 21 observed candidates, the remaining 15 were either not detected in spectroscopic observations, were observed and did not exhibit continuum emission (or spectral features), or were ruled out as lensing systems. The confirmed sample consists of one group-scale and five galaxy cluster-scale lenses. The lensed sources range in redshift z ~ 0.80-3.2...

  15. Observation and Confirmation of Six Strong Lensing Systems in The Dark Energy Survey Science Verification Data

    Energy Technology Data Exchange (ETDEWEB)

    Nord, B.; et al.

    2015-12-09

    We report the observation and confirmation of the first group- and cluster-scale strong gravitational lensing systems found in Dark Energy Survey (DES) data. Through visual inspection of data from the Science Verification (SV) season, we identified 53 candidate systems. We then obtained spectroscopic follow-up of 21 candidates using the Gemini Multi-Object Spectrograph (GMOS) at the Gemini South telescope and the Inamori-Magellan Areal Camera and Spectrograph (IMACS) at the Magellan/Baade telescope. With this follow-up, we confirmed six candidates as gravitational lenses: Three of the systems are newly discovered, and the remaining three were previously known. Of the 21 observed candidates, the remaining 15 were either not detected in spectroscopic observations, were observed and did not exhibit continuum emission (or spectral features), or were ruled out as lensing systems. The confirmed sample consists of one group-scale and five galaxy cluster-scale lenses. The lensed sources range in redshift z ~ 0.80-3.2, and in i-band surface brightness i_{SB} ~ 23-25 mag/sq.-arcsec. (2" aperture). For each of the six systems, we estimate the Einstein radius and the enclosed mass, which have ranges ~ 5.0 - 8.6" and ~ 7.5 x 10^{12} - 6.4 x 10^{13} solar masses, respectively.

  16. La tuberculose des amygdales palatines

    Directory of Open Access Journals (Sweden)

    Oudidi Abdelatif

    2010-01-01

    Full Text Available INTRODUCTION:La localisation tuberculeuse des amygdales palatines est très rare même dans un pays d’endémie tuberculeuse. Le diagnostic peut être suspecté cliniquement dans un contexte évocateur, mais il ne peut être certifié qu’au stade histologique. PATIENTS ET METHODES:Cinq cas de tuberculose des amygdales palatine ont été diagnostiqués sur une période de 5 ans et inclus dans une étude rétrospective. Nous avons recensé trois hommes et deux femmes (âge moyen de 28 ans. La dysphagie haute était le maître symptôme. L’examen a objectivé une hypertrophie amygdalienne chez tous les patients avec des ulcérations chez trois d’entre eux. Une biopsie a été effectuée chez trois patients et une amygdalectomie a été réalisée chez les deux autres. L’étude anatomopathologique a posé le diagnostic chez tous les patients. Un traitement médical antituberculeux selon un régime court allant de 6 à 9 mois a été instauré. Dans tous les cas, l’évolution à long terme a été favorable avec un recul moyen de 13 mois. CONCLUSION: La tuberculose amygdalienne est rare. Son diagnostic repose essentiellement sur le résultat anatomopathologique de la biopsie où de l’amygdalectomie. L’évolution sous traitement anti-bacillaire est souvent favorable, la récidive est exceptionnelle.

  17. Schopenhauer und die Paradoxien des Erhabenen

    Directory of Open Access Journals (Sweden)

    François Arnaud

    2012-08-01

    Full Text Available http://dx.doi.org/10.5007/1677-2954.2012v11nesp1p145Die Hauptunterscheidung zwischen den Schopenhauerschen und Kantschen Auffassungen des Erhabenen liegt nach diesem Artikel darin, dass der Zuschauer im letzten Fall zu einer nur möglichen Gefahr muss unterworfen werden, während er im Ersten wirklich erschreckt sein muss. Die Haupttriebfeder des Gefühls des Erhabenen ist nämlich bei Schopenhauer der Einsatz des Willens, der also wirklich bedroht werden muss. Daraus folgen einige Paradoxien und Originalitäten der Schopenhauerschen Lehre des Erhabenen, hauptsächlich aus dem ethischen Aussichtspunkt, deren Spuren ich zu folgen versuche.

  18. Improved Mask Protected DES using RSA Algorithm

    Directory of Open Access Journals (Sweden)

    Asha Latha S.

    2016-01-01

    Full Text Available The data encryption standard is a pioneering and farsighted standard which helped to set a new paradigm for encryption standards. But now DES is considered to be insecure for some application. Asymmetric mask protected DES is an advanced encryption method for effectively protecting the advanced DES. There are still probabilities to improve its security. This paper propose a method, which introduce a RSA key generation scheme in mask protected DES instead of plain key, which result in enhancement in the security of present asymmetric mask protected DES. We further propose a Vedic mathematical method of RSA implementation which reduce the complexity of computation in RSA block thereby resulting in reduced delay (four timesthat improves the performance of overall system. The software implementation was performed using Xilinx 13.2 and Model-Sim was used for the simulation environment.

  19. Des fantômes

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    Sjef Houppermans

    2012-12-01

    Full Text Available La première pièce de théâtre de Laurent Mauvignier, Tout mon amour, est créée en 2012 par la compagnie Les Possédés. La thématique habituelle de Mauvignier (secrets des familles, solitude, violence sociale s’y retrouve, mais tout en utilisant pleinement les moyens de la scène (distanciation, présence physique, espace théâtral, discours rythmés.

  20. A manual for prioritizing the topics of clinical practice guidelines for family physicians

    Directory of Open Access Journals (Sweden)

    Leila Mounesan

    2016-01-01

    Full Text Available Background: Development of a manual or well-defined criterion for prioritizing the topics of clinical practice guidelines (CPGs will help validate and organize this process evermore. This study was conducted to design an applicable manual that would prioritize the CPG topics for family physicians. Methods: This study was a multi-stage method using a qualitative approach that was conducted for the manual developing. The manual development process took place in four steps, as follows: Literature review, interviews with ten experts, preparing a list of criteria and determining its appropriateness by applying the RAND/UCLA Appropriateness method, and development of the final draft of the manual and pilot study. Results: Interview transcripts went under content analysis and were classified into eight main groups, 12 subgroups, and 85 themes. A comprehensive list consisting of fifty preliminary criteria were extracted. After summarizing and classifying the criteria, 12 appropriate criteria were evaluated using the RAND appropriateness method. Eventually, based on the literature review and our own results of the interview analysis, a manual consisting of five main sections and one clause on ethics was developed. Later, a pilot study was conducted on ten family physician topics, and prioritized by nine experts. Conclusions: The manual can be eyed as a tool ensuring the quality of the process of prioritizing CPG topics for family physicians, as it takes into account the issues involved in priority-setting. Selecting informed stakeholders for rating the criteria and ranking the topics was an issue that was greatly emphasized by the experts. Eventually, the application of this manual can be the first step toward systematizing the process of prioritizing CPG topics in the country.

  1. Prioritization of sub-watersheds based on morphometric analysis using geospatial technique in Piperiya watershed, India

    Science.gov (United States)

    Chandniha, Surendra Kumar; Kansal, Mitthan Lal

    2017-03-01

    Hydrological investigation and behavior of watershed depend upon geo-morphometric characteristics of catchment. Morphometric analysis is commonly used for development of regional hydrological model of ungauged watershed. A critical valuation and assessment of geo-morphometric constraints has been carried out. Prioritization of watersheds based on water plot capacity of Piperiya watershed has been evaluated by linear, aerial and relief aspects. Morphometric analysis has been attempted for prioritization for nine sub-watersheds of Piperiya watershed in Hasdeo river basin, which is a tributary of the Mahanadi. Sub-watersheds are delineated by ArcMap 9.3 software as per digital elevation model (DEM). Assessment of drainages and their relative parameters such as stream order, stream length, stream frequency, drainage density, texture ratio, form factor, circulatory ratio, elongation ratio, bifurcation ratio and compactness ratio has been calculated separately for each sub-watershed using the Remote Sensing (RS) and Geospatial techniques. Finally, the prioritized score on the basis of morphometric behavior of each sub-watershed is assigned and thereafter consolidated scores have been estimated to identify the most sensitive parameters. The analysis reveals that stream order varies from 1 to 5; however, the first-order stream covers maximum area of about 87.7 %. Total number of stream segment of all order is 1,264 in the watershed. The study emphasizes the prioritization of the sub-watersheds on the basis of morphometric analysis. The final score of entire nine sub-watersheds is assigned as per erosion threat. The sub-watershed with the least compound parameter value was assigned as highest priority. However, the sub-watersheds has been categorized into three classes as high (4.1-4.7), medium (4.8-5.3) and low (>5.4) priority on the basis of their maximum (6.0) and minimum (4.1) prioritized score.

  2. Prioritizing treatment of rare diseases: a survey of preferences of Norwegian doctors.

    Science.gov (United States)

    Desser, Arna S

    2013-10-01

    Understanding doctors' preferences for prioritizing treatment of rare diseases can provide an important context for policy makers who must decide whether to exempt rare disease treatments, which are often quite expensive, from standard cost-effectiveness criteria. We surveyed a random sample of 551 Norwegian doctors in November 2011 and compared results to a similar survey of the Norwegian population. Respondents chose whether to prioritize treatment of patients with rare versus common diseases and then decided how to allocate funds between the two groups for each of two scenarios: (1) equal costs per person and (2) higher costs for the rare disease. Respondents were randomized to treatment costs for the rare disease in the second scenario that were either 8 or 25 times higher than treating the common disease. Except for different prevalence, the diseases were described identically. Doctors displayed no general preference for prioritizing treatment of rare diseases, but a large number favored the principle of reserving a small share of funds for rare disease patients. Doctors' responses differed significantly from those of the general population when the rare disease was more costly to treat. A larger share of doctors prioritized the common disease group for treatment while a smaller share expressed indifference. When dividing funds between the two patient groups, doctors allocated a smaller share of funds to the rare disease. Doctors were much less likely than the general population to divide funds equally between the groups. This study indicates that there is little support among Norwegian doctors for prioritizing the treatment of rare diseases.

  3. Prioritization and evaluation of depression candidate genes by combining multidimensional data resources.

    Directory of Open Access Journals (Sweden)

    Chung-Feng Kao

    Full Text Available BACKGROUND: Large scale and individual genetic studies have suggested numerous susceptible genes for depression in the past decade without conclusive results. There is a strong need to review and integrate multi-dimensional data for follow up validation. The present study aimed to apply prioritization procedures to build-up an evidence-based candidate genes dataset for depression. METHODS: Depression candidate genes were collected in human and animal studies across various data resources. Each gene was scored according to its magnitude of evidence related to depression and was multiplied by a source-specific weight to form a combined score measure. All genes were evaluated through a prioritization system to obtain an optimal weight matrix to rank their relative importance with depression using the combined scores. The resulting candidate gene list for depression (DEPgenes was further evaluated by a genome-wide association (GWA dataset and microarray gene expression in human tissues. RESULTS: A total of 5,055 candidate genes (4,850 genes from human and 387 genes from animal studies with 182 being overlapped were included from seven data sources. Through the prioritization procedures, we identified 169 DEPgenes, which exhibited high chance to be associated with depression in GWA dataset (Wilcoxon rank-sum test, p = 0.00005. Additionally, the DEPgenes had a higher percentage to express in human brain or nerve related tissues than non-DEPgenes, supporting the neurotransmitter and neuroplasticity theories in depression. CONCLUSIONS: With comprehensive data collection and curation and an application of integrative approach, we successfully generated DEPgenes through an effective gene prioritization system. The prioritized DEPgenes are promising for future biological experiments or replication efforts to discover the underlying molecular mechanisms for depression.

  4. Who should be prioritized for renal transplantation?: Analysis of key stakeholder preferences using discrete choice experiments

    Directory of Open Access Journals (Sweden)

    Clark Michael D

    2012-11-01

    Full Text Available Abstract Background Policies for allocating deceased donor kidneys have recently shifted from allocation based on Human Leucocyte Antigen (HLA tissue matching in the UK and USA. Newer allocation algorithms incorporate waiting time as a primary factor, and in the UK, young adults are also favoured. However, there is little contemporary UK research on the views of stakeholders in the transplant process to inform future allocation policy. This research project aimed to address this issue. Methods Discrete Choice Experiment (DCE questionnaires were used to establish priorities for kidney transplantation among different stakeholder groups in the UK. Questionnaires were targeted at patients, carers, donors / relatives of deceased donors, and healthcare professionals. Attributes considered included: waiting time; donor-recipient HLA match; whether a recipient had dependents; diseases affecting life expectancy; and diseases affecting quality of life. Results Responses were obtained from 908 patients (including 98 ethnic minorities; 41 carers; 48 donors / relatives of deceased donors; and 113 healthcare professionals. The patient group demonstrated statistically different preferences for every attribute (i.e. significantly different from zero so implying that changes in given attributes affected preferences, except when prioritizing those with no rather than moderate diseases affecting quality of life. The attributes valued highly related to waiting time, tissue match, prioritizing those with dependents, and prioritizing those with moderate rather than severe diseases affecting life expectancy. Some preferences differed between healthcare professionals and patients, and ethnic minority and non-ethnic minority patients. Only non-ethnic minority patients and healthcare professionals clearly prioritized those with better tissue matches. Conclusions Our econometric results are broadly supportive of the 2006 shift in UK transplant policy which emphasized

  5. Interactogeneous: disease gene prioritization using heterogeneous networks and full topology scores.

    Directory of Open Access Journals (Sweden)

    Joana P Gonçalves

    Full Text Available Disease gene prioritization aims to suggest potential implications of genes in disease susceptibility. Often accomplished in a guilt-by-association scheme, promising candidates are sorted according to their relatedness to known disease genes. Network-based methods have been successfully exploiting this concept by capturing the interaction of genes or proteins into a score. Nonetheless, most current approaches yield at least some of the following limitations: (1 networks comprise only curated physical interactions leading to poor genome coverage and density, and bias toward a particular source; (2 scores focus on adjacencies (direct links or the most direct paths (shortest paths within a constrained neighborhood around the disease genes, ignoring potentially informative indirect paths; (3 global clustering is widely applied to partition the network in an unsupervised manner, attributing little importance to prior knowledge; (4 confidence weights and their contribution to edge differentiation and ranking reliability are often disregarded. We hypothesize that network-based prioritization related to local clustering on graphs and considering full topology of weighted gene association networks integrating heterogeneous sources should overcome the above challenges. We term such a strategy Interactogeneous. We conducted cross-validation tests to assess the impact of network sources, alternative path inclusion and confidence weights on the prioritization of putative genes for 29 diseases. Heat diffusion ranking proved the best prioritization method overall, increasing the gap to neighborhood and shortest paths scores mostly on single source networks. Heterogeneous associations consistently delivered superior performance over single source data across the majority of methods. Results on the contribution of confidence weights were inconclusive. Finally, the best Interactogeneous strategy, heat diffusion ranking and associations from the STRING database

  6. Dual indices for prioritizing investment in decentralized HIV services at Nigerian primary health care facilities.

    Science.gov (United States)

    Fronczak, Nancy; Oyediran, Kola' A; Mullen, Stephanie; Kolapo, Usman M

    2016-04-01

    Decentralizing health services, including those for HIV prevention and treatment, is one strategy for maximizing the use of limited resources and expanding treatment options; yet few methods exist for systematically identifying where investments for service expansion might be most effective, in terms of meeting needs and rapid availability of improved services. The Nigerian Government, the United States Government under the President's Emergency Plan for AIDS Relief (PEPFAR) program and other donors are expanding services for prevention of mother-to-child transmission (PMTCT) of HIV to primary health care facilities in Nigeria. Nigerian primary care facilities vary greatly in their readiness to deliver HIV/AIDS services. In 2012, MEASURE Evaluation assessed 268 PEPFAR-supported primary health care facilities in Nigeria and developed a systematic method for prioritizing these facilities for expansion of PMTCT services. Each assessed facility was scored based on two indices with multiple, weighted variables: one measured facility readiness to provide PMTCT services, the other measured local need for the services and feasibility of expansion. These two scores were compiled and the summary score used as the basis for prioritizing facilities for PMTCT service expansion. The rationale was that using need and readiness to identify where to expand PMTCT services would result in more efficient allocation of resources. A review of the results showed that the indices achieved the desired effect-that is prioritizing facilities with high need even when readiness was problematic and also prioritizing facilities where rapid scale-up was feasible. This article describes the development of the two-part index and discusses advantages of using this approach when planning service expansion. The authors' objective is to contribute to development of methodologies for prioritizing investments in HIV, as well as other public health arenas, that should improve cost-effectiveness and

  7. Problematique de la gestion des eaux souterraines au Maroc

    Directory of Open Access Journals (Sweden)

    Mennani, A.

    2002-08-01

    Full Text Available Maroc a toujours fait du développent du secteur de l'eau une priorité et un choix stratégique. Ce secteur qui constitue un des principaux leviers du développement économique et social, se trouve confronté a deux défis essentiels: - L'épuisement des ressources en eau en rapport avec l'accroissement de la demande en eau tous usages confondus, avec une tendance a la pénurie absolue d'ici 2025. - La dégradation des ressources en eau qui subissent différentes formes de pollution. La rareté des ressources en eau, et la forte irrégularité aussi bien spatiale, que temporelle, qui caractérisent le contexte marocain, ont conditionné les choix des pouvoirs publics 2 adopter une stratégie globale dont les résultats ont prouvé son efficacité particulikrement durant les périodes de sécheresse consécutives. Cette stratégie tout azimuts a concerné aussi bien le plan législatif et réglementaire, que le plan de la mobilisation et de la protection des ressources en eau. Les études de pldcation entreprises ont montré que les ressources en eau conventionnelles seront saturées au niveau de la majorité de bassins a l'horizon 2020, et que ces déficits prévus risquent d'gtre aggravés dans le cas de conjonction avec des périodes de sécheresse. La politique de mobilisation et de protection des ressources en eau, en particulier souterraine dont le potentiel mobilisable est de l'ordre de 4 milliards de m3 sur un total de 20 milliards, nécessite une gestion participative ainsi que le recours a de nouvelles approches et technologies pour compléter les méthodes conventionnelles utilisées jusqu'a présent.Marruecos siempre ha considerado prioritario y estratégico el desarrollo del sector del agua. Este sector, que constituye una de las principales palancas del desarrollo económico y social, se enfrenta a dos desafíos principales: - La disminución de los recursos hídricos en relación con el aumento de la demanda para todo tipo de

  8. Des pauvres de la politique à la politique des pauvres

    Directory of Open Access Journals (Sweden)

    Ratiba Hadj-Moussa

    2012-01-01

    Full Text Available S’attachant aux nouvelles modalités de production du politique issues des études subalternes, l’article situe dans un premier temps ces travaux et, dans un deuxième temps, en fait une présentation en s’appuyant sur les éléments qui y sont privilégiés et qui font le lien entre « les pauvres et la production du politique ». Cette présentation s’appuie essentiellement sur les travaux portant sur les pays du Sud, en particulier l’Inde et quelques pays du Moyen Orient (l’Égypte et l’Iran. Elle réfère aussi au Maghreb qui est le terrain principal de l’analyse. La présentation tient compte en particulier des travaux qui s’appuient sur des recherches empiriques substantielles mais dont la portée théorique est très peu discutée. Enfin, si le renvoi aux études subalternes ou postcoloniales est dans ce texte non négligeable, il est aussi fait recours à des travaux produits dans des contextes pluralistes, comme la France.Poor Policy to the Policy of the PoorThis article has its origins in the new methods of production of policy based on subaltern studies. Firstly, it will locate these studies and then it will present its main arguments as well as the relationship between “the poor and policy production”. This presentation is based essentially on the works on countries of the south, particularly India, and few other countries from the Middle East (Egypt and Iran. It also refers to North Africa, which is the major fieldwork of this analysis. This presentation takes into account the works that rely upon substantial empirical research but for which the theoretical range is very little. Finally, if the referral to subaltern or postcolonial studies is significant in this article, it also refers to works produced in pluralistic contexts such as France.De los pobres de la política a la política de los pobresBasándose en estudios subalternos, el artículo se sitúa dentro del marco de los nuevos modos de producci

  9. A meta-analysis based method for prioritizing candidate genes involved in a pre-specific function

    Directory of Open Access Journals (Sweden)

    Jingjing Zhai

    2016-12-01

    Full Text Available The identification of genes associated with a given biological function in plants remains a challenge, although network-based gene prioritization algorithms have been developed for Arabidopsis thaliana and many non-model plant species. Nevertheless, these network-based gene prioritization algorithms have encountered several problems; one in particular is that of unsatisfactory prediction accuracy due to limited network coverage, varying link quality, and/or uncertain network connectivity. Thus a model that integrates complementary biological data may be expected to increase the prediction accuracy of gene prioritization. Towards this goal, we developed a novel gene prioritization method named RafSee, to rank candidate genes using a random forest algorithm that integrates sequence, evolutionary, and epigenetic features of plants. Subsequently, we proposed an integrative approach named RAP (Rank Aggregation-based data fusion for gene Prioritization, in which an order statistics-based meta-analysis was used to aggregate the rank of the network-based gene prioritization method and RafSee, for accurately prioritizing candidate genes involved in a pre-specific biological function. Finally, we showcased the utility of RAP by prioritizing 380 flowering-time genes in Arabidopsis. The ‘leave-one-out’ cross-validation experiment showed that RafSee could work as a complement to a current state-of-art network-based gene prioritization system (AraNet v2. Moreover, RAP ranked 53.68% (204/380 flowering-time genes higher than AraNet v2, resulting in an 39.46% improvement in term of the first quartile rank. Further evaluations also showed that RAP was effective in prioritizing genes-related to different abiotic stresses. To enhance the usability of RAP for Arabidopsis and non-model plant species, an R package implementing the method is freely available at http://bioinfo.nwafu.edu.cn/software.

  10. A stakeholder-informed approach to the identification of criteria for the prioritization of zoonoses in Canada.

    Directory of Open Access Journals (Sweden)

    Victoria Ng

    Full Text Available BACKGROUND: Zoonotic diseases account for over 60% of all communicable diseases causing illness in humans and 75% of recently emerging infectious diseases. As limited resources are available for the control and prevention of zoonotic diseases, it is necessary to prioritize diseases in order to direct resources into those with the greatest needs. The selection of criteria for prioritization has traditionally been on the basis of expert opinion; however, details of the methods used to identify criteria from expert opinion often are not published and a full range of criteria may not be captured by expert opinion. METHODOLOGY/PRINCIPAL FINDINGS: This study used six focus groups to identify criteria for the prioritization of zoonotic diseases in Canada. Focus groups included people from the public, animal health professionals and human health professionals. A total of 59 criteria were identified for prioritizing zoonotic diseases. Human-related criteria accounted for the highest proportion of criteria identified (55%, followed by animal-related criteria (26% then pathogen/disease-related criteria (19%. Similarities and differences were observed in the identification and scoring of criteria for disease prioritization between groups; the public groups were strongly influenced by the individual-level of disease burden, the responsibility of the scientific community in disease prioritization and the experiences of recent events while the professional groups were influenced by the societal- and population-level of disease burden and political and public pressure. CONCLUSIONS/SIGNIFICANCE: This was the first study to describe a mixed semi-quantitative and qualitative approach to deriving criteria for disease prioritization. This was also the first study to involve the opinion of the general public regarding disease prioritization. The number of criteria identified highlights the difficulty in prioritizing zoonotic diseases. The method presented in this

  11. Évaluation des émissions de gaz à effet de serre des filières de traitement et de valorisation des boues issues du traitement des eaux usées

    OpenAIRE

    Reverdy, A.L.; Pradel, M.

    2011-01-01

    / Ce rapport présente l'inventaire des différentes consommations énergétiques, en consommables et des GES pour chaque poste de traitement et de valorisation des boues issues du traitement des eaux usées.

  12. Distribution spatiale intra-urbaine des particules fines : monitoring ...

    African Journals Online (AJOL)

    SARAH

    30 sept. 2014 ... Intra-urban spatial distribution of particulate matter: monitoring by leaf Saturation Isothermal Remanent ... les changements microclimatiques au sein des villes ... déterminer l'impact des saisons sur la teneur des ... Ce District jouit d'un climat de type ... Sélection et description des espèces : Un inventaire.

  13. Performances de production des cobayes (Cavia porcellus L.) en ...

    African Journals Online (AJOL)

    Au Cameroun, l'élevage des cobayes se pratique encore dans les cuisines et à même le sol et leur ..... Figure 1 : Evolution des poids des mères allaitantes de la naissance au sevrage des petits. .... lecture critique du manuscrit ; EM a participé.

  14. Isomers chart; Table des isomeres

    Energy Technology Data Exchange (ETDEWEB)

    Dupont-Gautier, P.; Chantelot, S.; Moisson, N. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-07-01

    The nuclear isomers are nuclides offering the same mass number and the same atomic number, but different energy levels. In the following chart the zero energy ground states are omitted and the metastable isomers, i.e. of non-zero energy, known and of measurable lifetime, are listed. The lower limit of this lifetime was set here to 0.1 x 10{sup -6} s. The various isomers were classified in increasing lifetimes. (authors) [French] Les isomeres nucleaires sont des nucleides presentant le meme nombre de masse et le meme numero atomique, mais des niveaux energetiques differents. Dans la table suivante, on a neglige les etats fondamentaux d'energie nulle et on a recense les isomeres metastables, c'est-a-dire d'energie non nulle, connus et de periode mesurable. La limite inferieure de cette periode a ete fixee ici a 0,1 x 10{sup -6} s. Les differents isomeres ont ete classes par periodes croissantes. (auteurs)

  15. Isomers chart; Table des isomeres

    Energy Technology Data Exchange (ETDEWEB)

    Dupont-Gautier, P.; Chantelot, S.; Moisson, N. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-07-01

    The nuclear isomers are nuclides offering the same mass number and the same atomic number, but different energy levels. In the following chart the zero energy ground states are omitted and the metastable isomers, i.e. of non-zero energy, known and of measurable lifetime, are listed. The lower limit of this lifetime was set here to 0.1 x 10{sup -6} s. The various isomers were classified in increasing lifetimes. (authors) [French] Les isomeres nucleaires sont des nucleides presentant le meme nombre de masse et le meme numero atomique, mais des niveaux energetiques differents. Dans la table suivante, on a neglige les etats fondamentaux d'energie nulle et on a recense les isomeres metastables, c'est-a-dire d'energie non nulle, connus et de periode mesurable. La limite inferieure de cette periode a ete fixee ici a 0,1 x 10{sup -6} s. Les differents isomeres ont ete classes par periodes croissantes. (auteurs)

  16. Comprehensive evidence-based assessment and prioritization of potential antidiabetic medicinal plants: a case study from canadian eastern james bay cree traditional medicine.

    Science.gov (United States)

    Haddad, Pierre S; Musallam, Lina; Martineau, Louis C; Harris, Cory; Lavoie, Louis; Arnason, John T; Foster, Brian; Bennett, Steffany; Johns, Timothy; Cuerrier, Alain; Coon Come, Emma; Coon Come, Rene; Diamond, Josephine; Etapp, Louise; Etapp, Charlie; George, Jimmy; Husky Swallow, Charlotte; Husky Swallow, Johnny; Jolly, Mary; Kawapit, Andrew; Mamianskum, Eliza; Petagumskum, John; Petawabano, Smalley; Petawabano, Laurie; Weistche, Alex; Badawi, Alaa

    2012-01-01

    Canadian Aboriginals, like others globally, suffer from disproportionately high rates of diabetes. A comprehensive evidence-based approach was therefore developed to study potential antidiabetic medicinal plants stemming from Canadian Aboriginal Traditional Medicine to provide culturally adapted complementary and alternative treatment options. Key elements of pathophysiology of diabetes and of related contemporary drug therapy are presented to highlight relevant cellular and molecular targets for medicinal plants. Potential antidiabetic plants were identified using a novel ethnobotanical method based on a set of diabetes symptoms. The most promising species were screened for primary (glucose-lowering) and secondary (toxicity, drug interactions, complications) antidiabetic activity by using a comprehensive platform of in vitro cell-based and cell-free bioassays. The most active species were studied further for their mechanism of action and their active principles identified though bioassay-guided fractionation. Biological activity of key species was confirmed in animal models of diabetes. These in vitro and in vivo findings are the basis for evidence-based prioritization of antidiabetic plants. In parallel, plants were also prioritized by Cree Elders and healers according to their Traditional Medicine paradigm. This case study highlights the convergence of modern science and Traditional Medicine while providing a model that can be adapted to other Aboriginal realities worldwide.

  17. Comprehensive Evidence-Based Assessment and Prioritization of Potential Antidiabetic Medicinal Plants: A Case Study from Canadian Eastern James Bay Cree Traditional Medicine

    Directory of Open Access Journals (Sweden)

    Pierre S. Haddad

    2012-01-01

    Full Text Available Canadian Aboriginals, like others globally, suffer from disproportionately high rates of diabetes. A comprehensive evidence-based approach was therefore developed to study potential antidiabetic medicinal plants stemming from Canadian Aboriginal Traditional Medicine to provide culturally adapted complementary and alternative treatment options. Key elements of pathophysiology of diabetes and of related contemporary drug therapy are presented to highlight relevant cellular and molecular targets for medicinal plants. Potential antidiabetic plants were identified using a novel ethnobotanical method based on a set of diabetes symptoms. The most promising species were screened for primary (glucose-lowering and secondary (toxicity, drug interactions, complications antidiabetic activity by using a comprehensive platform of in vitro cell-based and cell-free bioassays. The most active species were studied further for their mechanism of action and their active principles identified though bioassay-guided fractionation. Biological activity of key species was confirmed in animal models of diabetes. These in vitro and in vivo findings are the basis for evidence-based prioritization of antidiabetic plants. In parallel, plants were also prioritized by Cree Elders and healers according to their Traditional Medicine paradigm. This case study highlights the convergence of modern science and Traditional Medicine while providing a model that can be adapted to other Aboriginal realities worldwide.

  18. Physicians' Perceptions on the usefulness of contextual information for prioritizing and presenting alerts in computerized physician order entry systems

    Directory of Open Access Journals (Sweden)

    Jung Martin

    2012-10-01

    Full Text Available Abstract Background One possible approach towards avoiding alert overload and alert fatigue in Computerized Physician Order Entry (CPOE systems is to tailor their drug safety alerts to the context of the clinical situation. Our objective was to identify the perceptions of physicians on the usefulness of clinical context information for prioritizing and presenting drug safety alerts. Methods We performed a questionnaire survey, inquiring CPOE-using physicians from four hospitals in four European countries to estimate the usefulness of 20 possible context factors. Results The 223 participants identified the ‘severity of the effect’ and the ‘clinical status of the patient’ as the most useful context factors. Further important factors are the ‘complexity of the case’ and the ‘risk factors of the patient’. Conclusions Our findings confirm the results of a prior, comparable survey inquiring CPOE researchers. Further research should focus on implementing these context factors in CPOE systems and on subsequently evaluating their impact.

  19. Etude des effets du martelage repetitif sur les contraintes residuelles

    Science.gov (United States)

    Hacini, Lyes

    L'assemblage par soudage peut engendrer des contraintes residuelles. Ces contraintes provoquent des fissurations prematurees et un raccourcissement de la duree de vie des composants. Dans ce contexte, le martelage robotise est utilise pour relaxer ces contraintes residuelles. Trois volets sont presentes: le premier est l'evaluation des effets des impacts unitaires repetes sur le champ de contraintes developpe dans des plaques d'acier inoxydable austenitique 304L vierges ou contenant des contraintes residuelles initiales. Dans la deuxieme partie de ce projet, le martelage est applique grace au robot SCOMPI. Les contraintes residuelles induites et relaxees par martelage sont ensuite mesurees par la methode des contours, qui a ete adaptee a cet effet. Dans la troisieme partie, le martelage est modelise par la methode des elements finis. Un modele axisymetrique developpe grace au logiciel ANSYS permet de simuler des impacts repetes d'un marteau elastique sur une plaque ayant un comportement elastoplastique.

  20. Hypnose et douleurs chroniques: "est-ce que l'hypnose peut améliorer la qualité de vie des patients douloureux chroniques ?"

    OpenAIRE

    Granger, Julie; Duc, Céline; Hilfiker, Roger

    2012-01-01

    Au travers de cette revue systématique, nous souhaitons confirmer l’efficacité de l’hypnose dans le traitement de la douleur chronique. Nous avons recherché des études comparant deux groupes, l’un recevant uniquement des traitements physiothérapeutiques et l’autre de l’hypnose combinée à des traitements physiothérapeutiques. Mit dieser Systematischen Literaturübersicht möchten wir die Effizienz der Hypnose die Behandlung chronischer Schmerzen untersuchen. Wir haben Studien gesucht, die 2 G...

  1. À l’aube des dieux

    Directory of Open Access Journals (Sweden)

    Pascal Semonsut

    2011-03-01

    Full Text Available De l’avis même des préhistoriens, la Préhistoire assiste à la naissance du sentiment religieux. Cette religion des origines, quelle image en ont les Français ? Telle est la question que cet article aborde à partir de l’étude des manuels scolaires et des œuvres de fiction (littérature, cinéma et bande dessinée de la seconde moitié du XXe siècle. Si l’enseignement et la fiction n’accordent pas la même place à ce thème, en revanche tous deux font des préhistoriques des polythéistes adorant le soleil, construisant des mégalithes et prenant le plus grand soin de leurs morts. Ce mélange d’obscurantisme et de vraie spiritualité n’a qu’un but : montrer que notre espèce ne pouvait être que victorieuse dans ce combat qu’est l’humanisation.

  2. 75 caracteristiques et evolution des operations de fusions ...

    African Journals Online (AJOL)

    Nous décrivons dans un premier temps l'évolution de l'économie tunisienne et ..... grossistes, a réalisé en 2004 près de 88 % du chiffre d'affaires des transactions .... d'actions reste une opération soumise au droit commun des contrats et au droit des ..... tairement des opérations horizontales mettant en relation des entrepri-.

  3. L'espace mondial des grandes manifestations sportives internationales

    Directory of Open Access Journals (Sweden)

    Daniel MATHIEU

    1989-06-01

    Full Text Available La carte des grandes manifestations sportives mondiales montre une forte concentration des épreuves dans un petit nombre de pays développés, en particulier l'Europe occidentale. L'examen des nations concernées par les tournois majeurs du tennis et par le cyclisme professionnel soulignent, avec les nuances propres à chacun des sports, l'étroitesse des espaces intéressés.

  4. Applying Costs, Risks and Values Evaluation (CRAVE) methodology to Engineering Support Request (ESR) prioritization

    Science.gov (United States)

    Joglekar, Prafulla N.

    1994-01-01

    Given limited budget, the problem of prioritization among Engineering Support Requests (ESR's) with varied sizes, shapes, and colors is a difficult one. At the Kennedy Space Center (KSC), the recently developed 4-Matrix (4-M) method represents a step in the right direction as it attempts to combine the traditional criteria of technical merits only with the new concern for cost-effectiveness. However, the 4-M method was not adequately successful in the actual prioritization of ESRs for the fiscal year 1995 (FY95). This research identifies a number of design issues that should help us to develop better methods. It emphasizes that given the variety and diversity of ESR's one should not expect that a single method could help in the assessment of all ESR's. One conclusion is that a methodology such as Costs, Risks, and Values Evaluation (CRAVE) should be adopted. It also is clear that the development of methods such as 4-M requires input not only from engineers with technical expertise in ESR's but also from personnel with adequate background in the theory and practice of cost-effectiveness analysis. At KSC, ESR prioritization is one part of the Ground Support Working Teams (GSWT) Integration Process. It was discovered that the more important barriers to the incorporation of cost-effectiveness considerations in ESR prioritization lie in this process. The culture of integration, and the corresponding structure of review by a committee of peers, is not conducive to the analysis and confrontation necessary in the assessment and prioritization of ESR's. Without assistance from appropriately trained analysts charged with the responsibility to analyze and be confrontational about each ESR, the GSWT steering committee will continue to make its decisions based on incomplete understanding, inconsistent numbers, and at times, colored facts. The current organizational separation of the prioritization and the funding processes is also identified as an important barrier to the

  5. De la manipulation des images 3D

    Directory of Open Access Journals (Sweden)

    Geneviève Pinçon

    2012-04-01

    Full Text Available Si les technologies 3D livrent un enregistrement précis et pertinent des graphismes pariétaux, elles offrent également des applications particulièrement intéressantes pour leur analyse. À travers des traitements sur nuage de points et des simulations, elles autorisent un large éventail de manipulations touchant autant à l’observation qu’à l’étude des œuvres pariétales. Elles permettent notamment une perception affinée de leur volumétrie, et deviennent des outils de comparaison de formes très utiles dans la reconstruction des chronologies pariétales et dans l’appréhension des analogies entre différents sites. Ces outils analytiques sont ici illustrés par les travaux originaux menés sur les sculptures pariétales des abris du Roc-aux-Sorciers (Angles-sur-l’Anglin, Vienne et de la Chaire-à-Calvin (Mouthiers-sur-Boëme, Charente.If 3D technologies allow an accurate and relevant recording of rock art, they also offer several interesting applications for its analysis. Through spots clouds treatments and simulations, they permit a wide range of manipulations concerning figurations observation and study. Especially, they allow a fine perception of their volumetry. They become efficient tools for forms comparisons, very useful in the reconstruction of graphic ensemble chronologies and for inter-sites analogies. These analytical tools are illustrated by the original works done on the sculptures of Roc-aux-Sorciers (Angles-sur-l’Anglin, Vienne and Chaire-à-Calvin (Mouthiers-sur-Boëme, Charente rock-shelters.

  6. Mécanique des fluides fondamentale

    CERN Document Server

    Zeytounian, Radyadour K

    1991-01-01

    Ce cours de mecanique des fluides est avant tout un cours theorique qui repond aux questions fondamentales de ce sujet de recherche. Les quatre premiers chapitres presentent les equations propres a determiner l'ecoulement de fluide considere et diverses solutions. Les chapitres 5 et 6sont consacres aux problemes lies la stabilite, aux bifurcations et aux comportements chaotiques. Le livre donne un vision globale des questions traitees en mecanique des fluides qui sont a la base de toute la recherche, de la modelisation et de toutes les applications dans ce domaine.

  7. Écriture scientifique et évolution des croyances, des connaissances ou des conceptions des enseignants en reprise d’étude

    Directory of Open Access Journals (Sweden)

    Delarue-Breton Catherine

    2016-01-01

    Full Text Available Si l’on s’accorde assez unanimement – c’est à dire aux plans simultanément scientifique et institutionnel – à reconnaitre que l’initiation à la recherche est devenue nécessaire dans la formation des enseignants, les modalités de cette initiation, ses visées et ses effets font cependant peu l’objet, encore, d’un consensus, et dans certains cas, divisent. Nous avons pu étudier à diverses reprises, à partir de différentes versions des mémoires, le rôle de l’écriture scientifique dans l’appropriation des concepts théoriques par les étudiants de master MEEF (Métiers de l’Enseignement, de l’Éducation, de la Formation en formation initiale, autrement dit par les étudiants issus de licence, se destinant au métier de professeur des écoles. Nous avons ainsi pu mettre au jour d’une part la diversité de ces modes d’appropriation conceptuelle, et, en corrélation avec celle-ci, la diversité des modes d’analyse des situations scolaires, et d’autre part des formes d’évolution ou de stagnation des croyances, connaissances, conceptions de ces futurs enseignants sur le métier, sur les élèves, sur les disciplines, sur l’apprentissage. Notre propos est ici de nous poser des questions comparables, concernant le rapport entre appropriation théorique et évolution des conceptions non pas d’enseignants en formation initiale, mais d’enseignants titulaires en reprise d’étude, parfois eux-mêmes formateurs, inscrits en master MEEF avec validation des acquis. Nous questionnons ainsi le rôle de la recherche et de l’écriture scientifique dans la formation continue des enseignants.

  8. MESURE DE LA PERFORMANCE GLOBALE DES ENTREPRISES

    OpenAIRE

    Renaud, Angèle; Berland, Nicolas

    2007-01-01

    International audience; L'engagement des entreprises dans le développement durable consiste à conjuguer performance et responsabilité. La performance financière ne suffit plus à apprécier la performance d'une entreprise. Dès lors, les entreprises doivent mesurer leurs progrès à partir d'une performance plus globale incluant, en dehors de la dimension économique, des dimensions sociale et environnementale. A présent, comment mesurer cette performance globale ? Existe-il des outils de mesure gl...

  9. A l'écoute des professionnels

    CERN Document Server

    Lebre-Peytard, Monique

    1994-01-01

    Cet ouvrage s'adresse aux étudiants de niveau moyen ou avancé en français. Il propose un travail d'écoute, de réflexion et d'expression autour d'interview authentiques. Des professionnels parlent de leur métier, des entreprises où ils travaillent, des fonctions qu'ils occupent... Ils appartiennent à divers secteurs de l'économie : banque, mode, tourisme, agriculture, télécommunications, etc.

  10. Confirmation and Disconfirmation in Nurse/Physician Communication.

    Science.gov (United States)

    Garvin, Bonnie J.; Kennedy, Carol W.

    1986-01-01

    In an attempt to better understand the quality of interprofessional relationships, research used a confirmation/disconfirmation framework to analyze communication in nurse-physician dyads. Results indicated that nurses and physicians were primarily confirming in their interaction. (SRT)

  11. Contrôle des Circuits Auxiliaires des PFW (arrêt machines 2002/2003)

    CERN Document Server

    Ottaviani, J

    2003-01-01

    Les PFW sont des nappes polaires installées sur les pôles des aimants du PS. Elles sont au nombre de 4 par unité d aimant et constituées d un circuit principal (dans lequel circule le courant désiré selon le cycle magnétique utilisé) et de circuits auxiliaires. Les circuits auxiliaires sont des enroulements de correction (boucles de tour et pick-up brasés sur les enroulements). Pendant la variation du champ magnétique de l aimant PS, on utilise des tensions induites dans ces circuits auxiliaires pour corriger les erreurs de champ dues aux courants de Foucault dans la chambre à vide. Chaque année, pendant l arrêt machine, on vérifie si les caractéristiques des circuits auxiliaires correspondent aux normes (mesures des résistances des boucles de tours, résistances entre pick-up et isolation des circuits) afin de faire un suivi. Les 404 PFW sont ainsi vérifiées. Dans cette note, on ne relèvera que les PFW ayant des défauts (valeurs hors tolérances, boucles ouvertes ou en court-circuit, déf...

  12. Exploitation des connaissances issues des processus de retour d'expérience industriels

    OpenAIRE

    Jabrouni, Hicham

    2012-01-01

    Depuis plusieurs années, dans le secteur industriel, l’amélioration continue constitue un aspect important de la famille de normes ISO 9000 maintenue par l’organisation ISO (International Organization for Standardization). Elle se concentre sur l’amélioration de la satisfaction du client en passant par des améliorations continues et incrémentales des produits, des services et des processus. Afin de répondre à ces exigences, un point clé consiste à optimiser le processus de résolution de probl...

  13. Des changements concevables pour le secteur des transports dans l'objectif "Facteur 4"

    OpenAIRE

    Raux, Charles

    2007-01-01

    Au niveau mondial, les transports consomment 20% de l'énergie, dont 80% dans les transports routiers et 10% dans les transports aériens, et 95% de cette énergie est à base de pétrole. Le secteur des transports est l'un des principaux émetteurs de gaz à effet de serre dans la plupart des pays, et notamment du CO2 issu de la combustion des carburants fossiles. Pour que les transports contribuent significativement à l'objectif du « Facteur 4 » en 2050, trois pistes différentes mais complémentair...

  14. Typologie des investisseurs institutionnels et performance des firmes dans le contexte français

    OpenAIRE

    Jean-Michel SAHUT; Othmani Gharbi, Hidaya

    2011-01-01

    L’objet de cet article est d’analyser la relation entre les investisseurs institutionnels et la performance financière des firmes. Dans ce contexte, nous proposons une nouvelle typologie fondée sur la variété des comportements des institutionnels (passifs ou engagés (actifs)) vis-à-vis de la gestion et du gouvernement des firmes qu’ils détiennent en portefeuille, et identifions les principaux facteurs pouvant influencer ces comportements. Nos résultats corroborent, en général, un impact posit...

  15. Etude structurale des sites de nodulation et induction des nodules caulinaires chez Sesbania pubescens

    OpenAIRE

    TOMEKPE, Kodjo; Traore, A S; Ndiaye, S.; Spencer-Barreto, M.M.; Détrez, C.

    1992-01-01

    #Sesbania pubescens$ est une légumineuse annuelle voisine de #Sesbania rostrata$ qui se rencontre généralement sur les sols temporairement inondés de l'Afrique de l'Ouest. Des sites de nodulation préformes ont été mis en évidence sur sa tige et ses branches. Ces sites prennent naissance à l'aisselle des cotylédons et des feuilles. Comme chez la plupart des légumineuses à nodules de tige, les sites de nodulation caulinaire de #S. pubescens$ se développent en racines lorsque les tiges sont imme...

  16. Molekularbiologische Untersuchungen des Leitgewebes und der Stressphysiologie des Breitwegerichs (Plantago major L.)

    OpenAIRE

    Pommerrenig, Benjamin

    2008-01-01

    Die Leitbündel Höherer Pflanzen stellen die wesentlichen Gewebe zur Verteilung von Assimilaten, zum Transport von Wasser und zur Übermittlung von Informationen innerhalb und zwischen den einzelnen pflanzlichen Organen dar. Die Zellen des vaskulären Gewebes unterscheiden sich von denen des Mesophylls nicht nur in ihrer Gestalt und Funktion, sondern vor allem in ihrer Genexpression. In dieser Arbeit wurde zur Untersuchung des vaskulären Transkriptoms des Breitwege-richs (Plantago major) eine cD...

  17. Les lexiques des jeunes dans les discours écrits des blogs : pour une approche descriptive

    Directory of Open Access Journals (Sweden)

    Lorenz Paulina

    2014-07-01

    Full Text Available S’il ne faut pas confondre ce qui est appelé communément « langage SMS » et « langage des jeunes », nous avancerons toutefois que les pratiques langagières écrites des jeunes sur les supports modernes de communication, et notamment dans les blogs, présentent des particularités encore peu étudiées. Les traits observables les plus saillants sont ceux de la morphologie graphique, mais il n’en reste pas moins que certains jeunes utilisent des lexiques particuliers dans les blogs qui méritent une attention particulière. Nous nous proposons donc d’étudier les différents lexiques utilisés par des jeunes de 12 à 22 ans dans les blogs de la plateforme skyrock.com aux niveaux de sa diversité, de ses usages sémantiques variable d’un scripteur à l’autre pour un même mot, et de ses particularités morphosyntaxiques. En effet, nous observerons des lexiques divers allant des lexiques perçus comme relevant des cités à des lexiques perçus comme étant « branchés-jeunes », ou encore à des lexiques propres aux supports modernes de communication. Ainsi, nous analyserons des lexiques variés dans leurs usages écrits tels que bolos, bédave, gérer, ouf, tigen, ou encore des lexiques empruntés tels que mouv, full, etc., ainsi que des emplois particuliers de séquences autonomes comme lol. Quelques questions périphériques complèteront notre analyse telle que celles qui concerne l’influence des usages lexicaux entre pairs et le savoir partagé, la distinction de différentes communautés en fonction des lexiques utilisés, ou encore la variabilité des représentations graphiques d’un même mot.

  18. Study of Asphaltene Solutions by Electrical Conductivity Measurements Conductivité électrique des solutions d'asphaltènes

    Directory of Open Access Journals (Sweden)

    Behar E.

    2006-11-01

    Full Text Available The asphaltene interactions in model solutions were studied using a technique based on the electrical conductivity measurement. Interactions with n-heptane, resins, surfactants, water, phenol and NaCI were investigated. The conclusions drawn from this study confirmed previous opinions on aggregation mechanism of asphaltenes in solutions. They confirmed also the interpretation of asphaltene behaviour in terms of colloidal solution theories. Les interactions des asphaltènes avec leur environnement moléculaire dans des solutions modèles ont été étudiées par la mesure de la conductivité électrique de ces solutions. Les interactions avec le n-heptane, des résines, des tensioactifs, l'eau, le phénol et le chlorure de sodium ont été explorées. Les conclusions tirées de cette étude ont confirmé certaines hypothèses faites sur les mécanismes d'agrégation des asphaltènes en solution, en particulier dans le cadre de la théorie des solutions colloïdales.

  19. 42 CFR 32.87 - Confirmation of diagnosis.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Confirmation of diagnosis. 32.87 Section 32.87... Hansen's Disease § 32.87 Confirmation of diagnosis. At the earliest practicable date, after the arrival... the medical staff shall confirm or disprove the diagnosis of Hansen's disease. If the diagnosis...

  20. Prioritizing the effective factors for customers attraction: A case study of Sepah Bank

    Directory of Open Access Journals (Sweden)

    Azim Zarei

    2012-04-01

    Full Text Available During the past few years, privatization has recently changed banking industry and there has been an increase competition in this industry. New banks try to present better services to absorb customers and traditional banks attempt to improve their services to retain their existing customers. In such environment and with limited amount of resources, there is a necessity to prioritize different influencing factors on the quality of the services. The proposed study of this paper presents a multi criteria decision making method along with Kano method to prioritize the most influencing factors of service quality. The proposed study of this paper is implemented for one of the oldest banks in Iran called Sepah. We have gathered different factors influencing customer satisfaction for all Sepah banks located in Semnan, Iran and using, analytical hierarchy process we provide a detailed ranking.

  1. Identifying and prioritizing industry-level competitiveness factors: evidence from pharmaceutical market.

    Science.gov (United States)

    Shabaninejad, Hosein; Mehralian, Gholamhossein; Rashidian, Arash; Baratimarnani, Ahmad; Rasekh, Hamid Reza

    2014-04-03

    Pharmaceutical industry is knowledge-intensive and highly globalized, in both developed and developing countries. On the other hand, if companies want to survive, they should be able to compete well in both domestic and international markets. The main purpose of this paper is therefore to develop and prioritize key factors affecting companies' competitiveness in pharmaceutical industry. Based on an extensive literature review, a valid and reliable questionnaire was designed, which was later filled up by participants from the industry. To prioritize the key factors, we used the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS). The results revealed that human capital and macro-level policies were two key factors placed at the highest rank in respect of their effects on the competitiveness considering the industry-level in pharmaceutical area. This study provides fundamental evidence for policymakers and managers in pharma context to enable them formulating better polices to be proactively competitive and responsive to the markets' needs.

  2. The effects of resistance training prioritization in NCAA Division I Football summer training.

    Science.gov (United States)

    Smith, Robert A; Martin, Gerard J; Szivak, Tunde K; Comstock, Brett A; Dunn-Lewis, Courtenay; Hooper, David R; Flanagan, Shawn D; Looney, David P; Volek, Jeff S; Maresh, Carl M; Kraemer, William J

    2014-01-01

    Resistance training (RT) is an integral part of National Collegiate Athletic Association (NCAA) Division I Football performance programs. In the sport of football, there are several components that a strength and conditioning coach must be aware of. These include body mass, size, strength, power, speed, conditioning, and injury prevention, among others. The purpose of this study was to investigate if the RT component of a performance program could be prioritized for specific results using a nonlinear training model, grouping athletes by eligibility year. The NCAA Division I football student athletes were placed into 3 separate groups based on the playing year. All subjects participated in a 10-week, 4 days·week-1 off-season summer resistance training program. The training of group 1 (n = 20, age: 18.95 ± 0.76 years, height: 186.63 ± 7.21 cm, body mass: 97.66 ± 18.17 kg, playing year: 1.05 ± 0.22 years) prioritized hypertrophy-based RT to gain body mass. The training of group 2 (n = 20, age: 20.05 ± 1.05 years, height: 189.42 ± 5.49 cm, body mass: 106.99 ± 13.53 kg, and playing year: 2.35 ± 0.75 years) prioritized strength-based RT to gain strength. The training of group 3 (n = 20, age: 21.05 ± 1.10 years, height: 186.56 ± 6.73 cm, body mass: 109.8 ± 19.96 kg, playing year: 4.4 ± 0.50 years) prioritized power-based RT to gain power. Performance tests were evaluated during the first weeks of March (Spring) and August (Fall). The test measures included body mass (kilograms), 1-repetition maximum (1RM) bench press (kilograms), 1RM back squat (kilograms), 1RM power clean (kilograms), and countermovement vertical jump (CMVJ) height (centimeters). The primary findings of this investigation were as follows: group 1 saw significant increases in bench press maximum, back squat maximum, and power clean maximum (p ≤ 0.05). Group 2 saw significant increases in bench press maximum, back squat maximum, and power clean maximum (p ≤ 0.05). Group 3 saw a significant

  3. A Sustainability Assessment Methodology for Prioritizing the Technologies of Groundwater Contamination Remediation

    DEFF Research Database (Denmark)

    An, Da; Xi, Beidou; Wang, Yue

    2016-01-01

    More and more groundwater has 23 been polluted recently, and technologies for groundwater contamination remediation are of vital importance; however, it is usually difficult for the users to select the most suitable technology among multiple alternatives. In order to address this, this study aims...... at developing a sustainability assessment framework for prioritizing the technologies for groundwater contamination remediation by combining the concept of sustainability and multi-criteria decision making (MCDM) method. A criterion system which consists of six criteria in three aspects has been proposed...... for sustainability assessment of technologies for groundwater contamination remediation, and a novel MCDM method by combining the logarithmic fuzzy preference programming based fuzzy analytic hierarchy process and the improved ELECTRE method has been developed for prioritizing the alternatives. In order...

  4. A fuzzy ANP application for prioritizing the productivity factors based on university employees' counterproductive behaviors

    Directory of Open Access Journals (Sweden)

    Zahra Alipour Darvishi

    2014-07-01

    Full Text Available Measuring the relative efficiency of employee plays essential role on the success of any organization including universities. In this paper, we present a survey to detect and to prioritize important factors influencing on the productivity of employees who work for one of Iranian universities located in city of Tehran, Iran. The study also uses analytical network process to prioritize the factors. Based on the results of our survey, we have categorized effective productivity factors into three groups of research, educational and administration groups. In our survey, coherence and unity with no dispersion of the employee's duties, systematic job rotation and correct design communication job are among the most important factors influencing on employees’ productivity.

  5. Prioritization of Susceptibility Genes for Ectopic Pregnancy by Gene Network Analysis.

    Science.gov (United States)

    Liu, Ji-Long; Zhao, Miao

    2016-02-01

    Ectopic pregnancy is a very dangerous complication of pregnancy, affecting 1%-2% of all reported pregnancies. Due to ethical constraints on human biopsies and the lack of suitable animal models, there has been little success in identifying functionally important genes in the pathogenesis of ectopic pregnancy. In the present study, we developed a random walk-based computational method named TM-rank to prioritize ectopic pregnancy-related genes based on text mining data and gene network information. Using a defined threshold value, we identified five top-ranked genes: VEGFA (vascular endothelial growth factor A), IL8 (interleukin 8), IL6 (interleukin 6), ESR1 (estrogen receptor 1) and EGFR (epidermal growth factor receptor). These genes are promising candidate genes that can serve as useful diagnostic biomarkers and therapeutic targets. Our approach represents a novel strategy for prioritizing disease susceptibility genes.

  6. Effect of Instructions Prioritizing Speed or Accuracy on Kinematics and Kicking Performance in Football Players.

    Science.gov (United States)

    van den Tillaar, Roland; Fuglstad, Pål

    2017-01-01

    The authors' purpose was to investigate if there is a speed accuracy trade-off in soccer kicking by using instructions prioritizing velocity, accuracy, or both upon soccer kicking performance and kicking direction in experienced soccer players. In addition, kinematics were measured to investigate the eventual differences in performance. Thirteen experienced male footballers performed penalty kicks with different instructions prioritizing velocity, accuracy or both. Three-dimensional kinematics, together with maximal ball velocity and hitting accuracy, were measured on all kicks. The main findings were that when the main aim was accuracy, accuracy increased, while the velocity reduced, which supports Fitts' law (Fitts, 1954 ). In addition, kicking accuracy was higher when kicking to the contralateral side. The slower ball velocity was caused by lower segmental and in run velocities. These lower segmental velocities were mainly caused by the lower maximal knee extension and pelvis rotation during the accuracy priority kicks.

  7. Prioritized MPEG-4 Audio-Visual Objects Streaming over the DiffServ

    Institute of Scientific and Technical Information of China (English)

    HUANG Tian-yun; ZHENG Chan

    2005-01-01

    The object-based scalable coding in MPEG-4 is investigated, and a prioritized transmission scheme of MPEG-4 audio-visual objects (AVOs) over the DiffServ network with the QoS guarantee is proposed. MPEG-4 AVOs are extracted and classified into different groups according to their priority values and scalable layers (visual importance). These priority values are mapped to the IP DiffServ per hop behaviors (PHB). This scheme can selectively discard packets with low importance, in order to avoid the network congestion. Simulation results show that the quality of received video can gracefully adapt to network state, as compared with the 'best-effort' manner. Also, by allowing the content provider to define prioritization of each audio-visual object, the adaptive transmission of object-based scalable video can be customized based on the content.

  8. Component Prioritization Schema for Achieving Maximum Time and Cost Benefits from Software Testing

    Science.gov (United States)

    Srivastava, Praveen Ranjan; Pareek, Deepak

    Software testing is any activity aimed at evaluating an attribute or capability of a program or system and determining that it meets its required results. Defining the end of software testing represents crucial features of any software development project. A premature release will involve risks like undetected bugs, cost of fixing faults later, and discontented customers. Any software organization would want to achieve maximum possible benefits from software testing with minimum resources. Testing time and cost need to be optimized for achieving a competitive edge in the market. In this paper, we propose a schema, called the Component Prioritization Schema (CPS), to achieve an effective and uniform prioritization of the software components. This schema serves as an extension to the Non Homogenous Poisson Process based Cumulative Priority Model. We also introduce an approach for handling time-intensive versus cost-intensive projects.

  9. Identifying and prioritizing the indicators of talent management in recruiting radiology technicians

    Directory of Open Access Journals (Sweden)

    Sadegheh Hosseinzadeh Nojedeh

    2015-09-01

    Full Text Available The purpose of this study was identifying and prioritizing the indicators of talent management in recruiting the radiology technicians. The sample for the study was drawn randomly from all managers and personnel of the radiology sector in Ardabil public hospitals. Shannon entropy was applied to weighted criteria. In the next stage, for ranking the indicators of talent management, we employed multi-criteria decision-making techniques of TOPSIS method. Eight indicators were identified and prioritized using the TOPSIS method. These indicators are interest, commitment, skill, specialized knowledge, intelligence, the ability to solve the problem or issue, proper treatment with patient, and relationships with colleagues. The findings indicated that recruiting staff that do their work with love and are committed to the organization tend to be effective in improving hospital performance.

  10. Prioritization of territories for educational management in the Araucanía Region (Chile

    Directory of Open Access Journals (Sweden)

    Fernando Peña-Cortés

    2017-01-01

    Full Text Available In Chile, and particularly the Araucanía Region, mathematics learning has not reached the levels of development expected in the initial stages of formal education, as compared to other areas such as language. This study proposes to prioritize territories for educational management of mathematics through spatial and temporal assessment of results in the Sistema Nacional de Calidad de la Educación (simce test applied to children in 4th grade primary education during the period 1999-2011. This research suggests that there are more groups of territories than can be associated with the three levels of achievement traditionally used in Chile and that educational management should be applied at census district scale, considering differentiated policies for the different groups prioritized

  11. Topology association analysis in weighted protein interaction network for gene prioritization

    Science.gov (United States)

    Wu, Shunyao; Shao, Fengjing; Zhang, Qi; Ji, Jun; Xu, Shaojie; Sun, Rencheng; Sun, Gengxin; Du, Xiangjun; Sui, Yi

    2016-11-01

    Although lots of algorithms for disease gene prediction have been proposed, the weights of edges are rarely taken into account. In this paper, the strengths of topology associations between disease and essential genes are analyzed in weighted protein interaction network. Empirical analysis demonstrates that compared to other genes, disease genes are weakly connected with essential genes in protein interaction network. Based on this finding, a novel global distance measurement for gene prioritization with weighted protein interaction network is proposed in this paper. Positive and negative flow is allocated to disease and essential genes, respectively. Additionally network propagation model is extended for weighted network. Experimental results on 110 diseases verify the effectiveness and potential of the proposed measurement. Moreover, weak links play more important role than strong links for gene prioritization, which is meaningful to deeply understand protein interaction network.

  12. PRIORITIZING HIGHER EDUCATION BALANCED SCORECARD PERFORMANCE INDICATORS USING FUZZY APPROACH IN AN IRANIAN CONTEXT

    Directory of Open Access Journals (Sweden)

    Daryush Farid

    2008-10-01

    Full Text Available Higher education institutes are facing new challenges in order to improve the quality of education. There is a pressure for restructuring and reforming higher education in order to provide quality education and bring up graduates who become fruitful members of their societies. In higher education as in business there are acceptable conventions of measuring excellence. As a result, the implementation of Balanced Scorecard in higher education has been a target of interest in recent years. However, rather than emphasizing on financial performance, higher education has emphasized on academic measures in its Balanced Scorecard. This paper aims to prioritize performance indicators within the higher education balanced scorecard using fuzzy TOPSIS technique.Because Fuzzy Theory is a better approach in comparison to Logical Theory in case of measuring linguistic terms, therefore this paper tries to apply a fuzzy approach in prioritizing the performance indicators introduced by Balanced Scorecard.

  13. Peste des Petits Ruminants Virus.

    Science.gov (United States)

    Baron, M D; Diallo, A; Lancelot, R; Libeau, G

    2016-01-01

    Peste des petits ruminants virus (PPRV) causes a severe contagious disease of sheep and goats and has spread extensively through the developing world. Because of its disproportionately large impact on the livelihoods of low-income livestock keepers, and the availability of effective vaccines and good diagnostics, the virus is being targeted for global control and eventual eradication. In this review we examine the origin of the virus and its current distribution, and the factors that have led international organizations to conclude that it is eradicable. We also review recent progress in the molecular and cellular biology of the virus and consider areas where further research is required to support the efforts being made by national, regional, and international bodies to tackle this growing threat. © 2016 Elsevier Inc. All rights reserved.

  14. Utilisation des mousses et des pâtes syntactiques pour combler les lacunes des poteries archéologiques

    Directory of Open Access Journals (Sweden)

    Viviane Bechoux

    2008-10-01

    Full Text Available Filling potteries missing parts with plaster raises now complex problems during the de-restoration treatments. Ceramics restorers have recurrently questions on the use of plaster in the field of archaeological ceramics restoration. Some researches point to the choice of other filling materials. At the present time other methods can be devised by proposing plaster replacement by a lightened composite material: syntactic foams and pastes.Le comblement des lacunes des poteries à partir du plâtre pose actuellement des problèmes complexes lors des traitements de dérestauration. Les restaurateurs de céramiques s'interrogent de manière récurrente sur l'utilisation du plâtre dans le domaine de la restauration des céramiques archéologiques. Des recherches s'orientent vers le choix d'autres matériaux d'obturation. Actuellement, d'autres méthodes peuvent être mises en place en proposant le remplacement du plâtre par un matériau composite allégé, les mousses et les pâtes syntactiques.

  15. Spillover of Peste des Petits Ruminants Virus from Domestic to Wild Ruminants in the Serengeti Ecosystem, Tanzania.

    Science.gov (United States)

    Mahapatra, Mana; Sayalel, Kuya; Muniraju, Murali; Eblate, Ernest; Fyumagwa, Robert; Shilinde, Ligge; Mdaki, Maulid; Keyyu, Julius; Parida, Satya; Kock, Richard

    2015-12-01

    We tested wildlife inhabiting areas near domestic livestock, pastures, and water sources in the Ngorongoro district in the Serengeti ecosystem of northern Tanzania and found 63% seropositivity for peste des petits ruminants virus. Sequencing of the viral genome from sick sheep in the area confirmed lineage II virus circulation.

  16. A Toxicological Framework for the Prioritization of Children’s Safe Product Act Data

    OpenAIRE

    Smith, Marissa N.; Joshua Grice; Alison Cullen; Faustman, Elaine M.

    2016-01-01

    In response to concerns over hazardous chemicals in children’s products, Washington State passed the Children’s Safe Product Act (CSPA). CSPA requires manufacturers to report the concentration of 66 chemicals in children’s products. We describe a framework for the toxicological prioritization of the ten chemical groups most frequently reported under CSPA. The framework scores lifestage, exposure duration, primary, secondary and tertiary exposure routes, toxicokinetics and chemical properties ...

  17. Use of dependency and prioritization tools by clinical nurse specialists in palliative care: an exploratory study.

    LENUS (Irish Health Repository)

    Bracken, Mairéad

    2011-12-01

    The principal aim was to assess the utility of three needs assessment\\/dependency tools for use in community-based palliative care services. Specific objectives were to assess a sample of patients receiving specialist palliative care community nursing using these tools, to assess the predictive ability of each tool, and to explore the utility of prioritizing and measuring patient dependency from a clinical nurse specialist (CNS) perspective.

  18. A Systematic Process to Prioritize Prevention Activities: Sustaining Progress Toward the Reduction of Military Injuries

    Science.gov (United States)

    2010-01-01

    avoids overtraining and utilizes agility- ike training has been found to reduce physical training– elated injuries while meeting desired physical fıtness...M F A P ( S v d v C t 2 P A Systematic Process to Prioritize Prevention Activities Sustaining Progress Toward the Reduction of Military Injuries ...Schaefer, MD, MPH, Galen Barbour, MD, Kenneth S. Yew, MD, Bruce H. Jones, MD, MPH Background: To sustain progress toward injury reduction and other

  19. Prioritizing social and economic effects of sport places on Urban Environment (A case study: Yazd City)

    OpenAIRE

    2013-01-01

    Extended Abstract1- IntroductionSport facilities and sport places as one of important land uses in urban environment can have positive and negative effects on their surroundings, of which the most important can be addressed to economic and social ones. Thus, the purpose of this study was to identify, assess and prioritize the social and economic effects of sport places on the urban environment. Based on these objectives, five typical sport places (Shahid Sadoughi, Shahid Paak Nejad, Shahid Na...

  20. Identification and prioritization of management practices to reduce methylmercury exports from wetlands and irrigated agricultural lands.

    Science.gov (United States)

    McCord, Stephen A; Heim, Wesley A

    2015-03-01

    The Sacramento-San Joaquin Delta's (Delta) beneficial uses for humans and wildlife are impaired by elevated methylmercury (MeHg) concentrations in fish. MeHg is a neurotoxin that bioaccumulates in aquatic food webs. The total maximum daily load (TMDL) implementation plan aimed at reducing MeHg in Delta fish obligates dischargers to conduct MeHg control studies. Over 150 stakeholders collaborated to identify 24 management practices (MPs) addressing MeHg nonpoint sources (NPS) in three categories: biogeochemistry (6), hydrology (14), and soil/vegetation (4). Land uses were divided into six categories: permanently and seasonally flooded wetlands, flooded and irrigated agricultural lands, floodplains, and brackish-fresh tidal marshes. Stakeholders scored MPs based on seven criteria: scientific certainty, costs, MeHg reduction potential, spatial applicability, technical capacity to implement, negative impacts to beneficial uses, and conflicting requirements. Semi-quantitative scoring for MPs applicable to each land use (totaling >400 individual scores) led to consensus-based prioritization. This process relied on practical experience from diverse and accomplished NPS stakeholders and synthesis of 17 previous studies. Results provide a comprehensive, stakeholder-driven prioritization of MPs for wetland and irrigated agricultural land managers. Final prioritization highlights the most promising MPs for practical application and control study, and a secondary set of MPs warranting further evaluation. MPs that address hydrology and soil/vegetation were prioritized because experiences were positive and implementation appeared more feasible. MeHg control studies will need to address the TMDL conundrum that MPs effective at reducing MeHg exports could both exacerbate MeHg exposure and contend with other management objectives on site.