WorldWideScience

Sample records for conduit kernspintomografie zur

  1. Flexible cryogenic conduit

    International Nuclear Information System (INIS)

    Brindza, P.D.; Wines, R.R.; Takacs, J.J.

    1999-01-01

    A flexible and relatively low cost cryogenic conduit is described. The flexible cryogenic conduit of the present invention comprises a first inner corrugated tube with single braided serving, a second outer corrugated tube with single braided serving concentric with the inner corrugated tube, and arranged outwardly about the periphery of the inner corrugated tube and between the inner and outer corrugated tubes: a superinsulation layer; a one half lap layer of polyester ribbon; a one half lap layer of copper ribbon; a spirally wound refrigeration tube; a second one half lap layer of copper ribbon; a second one half lap layer of polyester ribbon; a second superinsulation layer; a third one half lap layer of polyester ribbon; and a spirally wound stretchable and compressible filament

  2. Sealing a conduit end

    International Nuclear Information System (INIS)

    Mentz, R.M.

    1993-01-01

    An apparatus for sealing or blocking conduits, such as the primary nozzles of a nuclear steam generator is described. It includes an annular bracket sealingly attached to the open end of the nozzle, the bracket having a plurality of threaded holes therein. Mounted atop the bracket is a generally circular nozzle dam for covering the opening. Interposed between the nozzle dam and the bracket is an extrusion-resistant seal member having a plurality of apertures therethrough for receiving each bolt. The seal member is configured to resist extrusion by having laminated layers of differing hardnesses, so that the seal member will not laterally extrude away from each bolt in a manner that enlarges the aperture surrounding each bolt as the nozzle dam is bolted to the bracket. (author)

  3. Peripheral nerve conduits: technology update

    Science.gov (United States)

    Arslantunali, D; Dursun, T; Yucel, D; Hasirci, N; Hasirci, V

    2014-01-01

    Peripheral nerve injury is a worldwide clinical problem which could lead to loss of neuronal communication along sensory and motor nerves between the central nervous system (CNS) and the peripheral organs and impairs the quality of life of a patient. The primary requirement for the treatment of complete lesions is a tension-free, end-to-end repair. When end-to-end repair is not possible, peripheral nerve grafts or nerve conduits are used. The limited availability of autografts, and drawbacks of the allografts and xenografts like immunological reactions, forced the researchers to investigate and develop alternative approaches, mainly nerve conduits. In this review, recent information on the various types of conduit materials (made of biological and synthetic polymers) and designs (tubular, fibrous, and matrix type) are being presented. PMID:25489251

  4. The corrosion effect on the conduit systems

    International Nuclear Information System (INIS)

    Laaidi, Naouar; Belattar, Sougratti

    2009-01-01

    The conduits in the buildings require a regular and permanent control, in order to avoid the risks of deterioration caused by the corrosion or the escape of water. In this work, we present a thermal nondestructive testing method of concrete structures containing water conduits, based on numerical modeling in three dimensions. The goal is to study the detectability of these conduits in different situations and to give a thermal characterization of the rust behaviour in the steel conduits. (author)

  5. Peripheral nerve conduits: technology update

    Directory of Open Access Journals (Sweden)

    Arslantunali D

    2014-12-01

    Full Text Available D Arslantunali,1–3,* T Dursun,1,2,* D Yucel,1,4,5 N Hasirci,1,2,6 V Hasirci,1,2,7 1BIOMATEN, Center of Excellence in Biomaterials and Tissue Engineering, Middle East Technical University (METU, Ankara, Turkey; 2Department of Biotechnology, METU, Ankara, Turkey; 3Department of Bioengineering, Gumushane University, Gumushane, Turkey; 4Faculty of Engineering, Department of Medical Engineering, Acibadem University, Istanbul, Turkey; 5School of Medicine, Department of Histology and Embryology, Acibadem University, Istanbul, Turkey; 6Department of Chemistry, Faculty of Arts and Sciences, METU, Ankara, Turkey; 7Department of Biological Sciences, Faculty of Arts and Sciences, METU, Ankara, Turkey *These authors have contributed equally to this work Abstract: Peripheral nerve injury is a worldwide clinical problem which could lead to loss of neuronal communication along sensory and motor nerves between the central nervous system (CNS and the peripheral organs and impairs the quality of life of a patient. The primary requirement for the treatment of complete lesions is a tension-free, end-to-end repair. When end-to-end repair is not possible, peripheral nerve grafts or nerve conduits are used. The limited availability of autografts, and drawbacks of the allografts and xenografts like immunological reactions, forced the researchers to investigate and develop alternative approaches, mainly nerve conduits. In this review, recent information on the various types of conduit materials (made of biological and synthetic polymers and designs (tubular, fibrous, and matrix type are being presented. Keywords: peripheral nerve injury, natural biomaterials, synthetic biomaterials

  6. Die Transition zur pflegenden Tochter

    Directory of Open Access Journals (Sweden)

    Dagmar Dräger

    2004-11-01

    Full Text Available Das Buch aus der Reihe „Studien zur Gesundheits- und Pflegewissenschaft“ beschreibt den theoretischen Hintergrund, das methodische Vorgehen und die Ergebnisse einer biografischen Untersuchung, die sich dem Übergang von der Tochter zur pflegenden Tochter widmete. Grundlage der Publikation ist die Dissertation (2002 der Autorin. Mit der Berücksichtigung biographischer und familiärer Hintergründe wird eine neue Perspektive in der Forschung zu pflegenden Angehörigen eingenommen.

  7. Conduit for regeneration of biological material

    DEFF Research Database (Denmark)

    2016-01-01

    The present invention relates to a conduit comprising a first material, having 1) a through-going hole, 2) fibers aligned along the long-axis in the through-going hole, each fiber having a diameter in the range 200-2000 nm. The conduit is preferably for regeneration of biological material, even...

  8. 47 CFR 32.2441 - Conduit systems.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Conduit systems. 32.2441 Section 32.2441 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES UNIFORM SYSTEM OF ACCOUNTS FOR TELECOMMUNICATIONS COMPANIES Instructions for Balance Sheet Accounts § 32.2441 Conduit systems. (a...

  9. Bentall Operation with Valved Homograft Conduit

    Science.gov (United States)

    Choudhary, Shiv K.; Talwar, Sachin; Kumar, A. Sampath

    2000-01-01

    Lesions of the ascending aorta associated with aortic valve disease are usually treated by implanting a prosthetic valved conduit (Bentall procedure). In this report, we present our experience in which a valved homograft conduit was used for the procedure. Six patients underwent a Bentall procedure with the use of a cryopreserved valved homograft conduit. Two of the patients had annuloaortic ectasia, 2 had Marfan syndrome, and 1 had an atherosclerotic aneurysm of the aorta. One patient had severe aortic stenosis due to a bicuspid aortic valve, along with an aneurysm and localized dissection of the ascending aorta. In all of the patients, the aortic annulus was substantially dilated, with accompanying moderate-to-severe aortic regurgitation. A standard procedure was performed with moderate hypothermia, cardiopulmonary bypass, and aortic and bicaval cannulation. The ascending aorta and the aortic valve were replaced with a cryopreserved valved homograft conduit (aortic in 5 patients and pulmonary in 1). The native coronary ostia were anastomosed directly to the homograft. Echocardiography, which was performed intraoperatively, before discharge from the hospital, and at follow-up visits (1 to 36 months), revealed good valve function without dilatation of the homograft conduits. There was 1 late death due to Aspergillus fumigatus endocarditis, 6 months postoperatively. In 1 patient, magnetic resonance imaging performed at 24 months revealed normal caliber of the homograft conduit. We conclude that the Bentall procedure can be performed, safely and with excellent results, using cryopreserved homograft conduits. PMID:11198310

  10. Conduit enlargement in an eogenetic karst aquifer

    Science.gov (United States)

    Moore, Paul J.; Martin, Jonathan B.; Screaton, Elizabeth J.; Neuhoff, Philip S.

    2010-11-01

    SummaryMost concepts of conduit development have focused on telogenetic karst aquifers, where low matrix permeability focuses flow and dissolution along joints, fractures, and bedding planes. However, conduits also exist in eogenetic karst aquifers, despite high matrix permeability which accounts for a significant component of flow. This study investigates dissolution within a 6-km long conduit system in the eogenetic Upper Floridan aquifer of north-central Florida that begins with a continuous source of allogenic recharge at the Santa Fe River Sink and discharges from a first-magnitude spring at the Santa Fe River Rise. Three sources of water to the conduit include the allogenic recharge, diffuse recharge through epikarst, and mineralized water upwelling from depth. Results of sampling and inverse modeling using PHREEQC suggest that dissolution within the conduit is episodic, occurring only during 30% of 16 sampling times between March 2003 and April 2007. During low flow conditions, carbonate saturated water flows from the matrix to the conduit, restricting contact between undersaturated allogenic water with the conduit wall. When gradients reverse during high flow conditions, undersaturated allogenic recharge enters the matrix. During these limited periods, estimates of dissolution within the conduit suggest wall retreat averages about 4 × 10 -6 m/day, in agreement with upper estimates of maximum wall retreat for telogenetic karst. Because dissolution is episodic, time-averaged dissolution rates in the sink-rise system results in a wall retreat rate of about 7 × 10 -7 m/day, which is at the lower end of wall retreat for telogenetic karst. Because of the high permeability matrix, conduits in eogenetic karst thus enlarge not just at the walls of fractures or pre-existing conduits such as those in telogenetic karst, but also may produce a friable halo surrounding the conduits that may be removed by additional mechanical processes. These observations stress the

  11. Stochastic simulation of karst conduit networks

    Science.gov (United States)

    Pardo-Igúzquiza, Eulogio; Dowd, Peter A.; Xu, Chaoshui; Durán-Valsero, Juan José

    2012-01-01

    Karst aquifers have very high spatial heterogeneity. Essentially, they comprise a system of pipes (i.e., the network of conduits) superimposed on rock porosity and on a network of stratigraphic surfaces and fractures. This heterogeneity strongly influences the hydraulic behavior of the karst and it must be reproduced in any realistic numerical model of the karst system that is used as input to flow and transport modeling. However, the directly observed karst conduits are only a small part of the complete karst conduit system and knowledge of the complete conduit geometry and topology remains spatially limited and uncertain. Thus, there is a special interest in the stochastic simulation of networks of conduits that can be combined with fracture and rock porosity models to provide a realistic numerical model of the karst system. Furthermore, the simulated model may be of interest per se and other uses could be envisaged. The purpose of this paper is to present an efficient method for conditional and non-conditional stochastic simulation of karst conduit networks. The method comprises two stages: generation of conduit geometry and generation of topology. The approach adopted is a combination of a resampling method for generating conduit geometries from templates and a modified diffusion-limited aggregation method for generating the network topology. The authors show that the 3D karst conduit networks generated by the proposed method are statistically similar to observed karst conduit networks or to a hypothesized network model. The statistical similarity is in the sense of reproducing the tortuosity index of conduits, the fractal dimension of the network, the direction rose of directions, the Z-histogram and Ripley's K-function of the bifurcation points (which differs from a random allocation of those bifurcation points). The proposed method (1) is very flexible, (2) incorporates any experimental data (conditioning information) and (3) can easily be modified when

  12. Pumped Storage and Potential Hydropower from Conduits

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2015-02-25

    Th is Congressional Report, Pumped Storage Hydropower and Potential Hydropower from Conduits, addresses the technical flexibility that existing pumped storage facilities can provide to support intermittent renewable energy generation. This study considered potential upgrades or retrofit of these facilities, the technical potential of existing and new pumped storage facilities to provide grid reliability benefits, and the range of conduit hydropower opportunities available in the United States.

  13. Kurzskala zur Erfassung der Unternehmenskultur

    OpenAIRE

    Jöns, Ingela; Hodapp, Markus; Weiss, Katharina

    2005-01-01

    Die Kulturskala zur Erfassung der Unternehmenskultur (KUK) fokussiert auf die Einstufung der Kultur des eigenen Unternehmens und eines anderen Unternehmens durch die Mitarbeiter, wie dies z.B. im Fall von Fusionen von Bedeutung ist. Ihre vier Dimensionen (Strategie, Struktur, Führung und Zusammenarbeit) werden anhand eines bündigen Inventars von 15 Merkmalen erfasst. In einer Untersuchung bei drei Unternehmen der Chemie- und Energiebranche mit einer Gesamtstichprobe von n = 724 konnte gezeigt...

  14. Conduit Stability and Collapse in Explosive Volcanic Eruptions: Coupling Conduit Flow and Failure Models

    Science.gov (United States)

    Mullet, B.; Segall, P.

    2017-12-01

    Explosive volcanic eruptions can exhibit abrupt changes in physical behavior. In the most extreme cases, high rates of mass discharge are interspaced by dramatic drops in activity and periods of quiescence. Simple models predict exponential decay in magma chamber pressure, leading to a gradual tapering of eruptive flux. Abrupt changes in eruptive flux therefore indicate that relief of chamber pressure cannot be the only control of the evolution of such eruptions. We present a simplified physics-based model of conduit flow during an explosive volcanic eruption that attempts to predict stress-induced conduit collapse linked to co-eruptive pressure loss. The model couples a simple two phase (gas-melt) 1-D conduit solution of the continuity and momentum equations with a Mohr-Coulomb failure condition for the conduit wall rock. First order models of volatile exsolution (i.e. phase mass transfer) and fragmentation are incorporated. The interphase interaction force changes dramatically between flow regimes, so smoothing of this force is critical for realistic results. Reductions in the interphase force lead to significant relative phase velocities, highlighting the deficiency of homogenous flow models. Lateral gas loss through conduit walls is incorporated using a membrane-diffusion model with depth dependent wall rock permeability. Rapid eruptive flux results in a decrease of chamber and conduit pressure, which leads to a critical deviatoric stress condition at the conduit wall. Analogous stress distributions have been analyzed for wellbores, where much work has been directed at determining conditions that lead to wellbore failure using Mohr-Coulomb failure theory. We extend this framework to cylindrical volcanic conduits, where large deviatoric stresses can develop co-eruptively leading to multiple distinct failure regimes depending on principal stress orientations. These failure regimes are categorized and possible implications for conduit flow are discussed, including

  15. Neuer Beitrag zur Kenntnis aussereuropaeischer Trichopteren

    NARCIS (Netherlands)

    Ulmer, Georg

    1906-01-01

    In den folgenden Mitteilungen findet man alles veröffentlicht, was mir zur Zeit an neuem und wenig bekannten Materiale (mit Ausnahme amerikanischer Arten, für die mir keine Typen vorliegen) zur Verfügung steht. Herr Dr. H. W. van der Weele in Leiden war so freundlich, mir die aussereuropäischen

  16. Von der lernenden Region zur "Smart Region“

    OpenAIRE

    Poschwatta, Wolfgang

    2004-01-01

    Von der lernenden Region zur "Smart Region“ / M. Hilpert, W. Poschwatta. - In: Nabizadeh-Araghi, Nima : Auf dem Weg zur "Smart Region" : regionale Entwicklung am Beispiel der Pistazienproduktion im Iran. - Augsburg : Müllerdruck, 2004. - S. 5-9. - (Terra facta ; 2)

  17. Extreme loads seismic testing of conduit systems

    International Nuclear Information System (INIS)

    Howard, G.E.; Ibanez, P.; Harrison, S.; Shi, Z.T.

    1991-01-01

    Rigid steel conduit (thin-wall tubes with threaded connections) containing electrical cabling are a common feature in nuclear power plants. Conduit systems are in many cases classified in U.S.A. practice as Seismic Category I structures. this paper summarizes results and others aspects of a dynamic test program conducted to investigate conduit systems seismic performance under three-axis excitation for designs representative at a nuclear power plant sited near Ft. Worth, Texas (a moderate seismic zone), with a Safe Shutdown Earthquake (SSE) of 0.12 g. Test specimens where subjected to postulated seismic events, including excitation well in excess of Safe Shutdown Earthquake events typical for U.S.A. nuclear power stations. A total of 18 conduit systems of 9-meter nominal lengths were shake table mounted and subjected to a variety of tests. None of the specimens suffered loss of load capacity when subjected to a site-enveloping Safe Shutdown Earthquake (SSE). Clamp/attachment hardware failures only began to occur when earthquake input motion was scaled upward to minimum values of 2.3-4.6 times site enveloping SSE response spectra. Tensile and/or shear failure of clamp attachment bolts or studs was the failure mode in all case in which failure was induced. (author)

  18. Drill pipes and casings utilizing multi-conduit tubulars

    Energy Technology Data Exchange (ETDEWEB)

    Curlett, H.B.

    1989-01-24

    A seal adapted for use with a multi-conduit well tubular, or the like, is described which consists of: a plate with fluid passages, each passage corresponding to an opening of a conduit of the multiconduit tubular, and a groove on the plate around each passage; and elastomer means partially embeddable into each groove for sealing each conduit of a tubular to a corresponding conduit of another similar tubular.

  19. Characterization of Zur-dependent genes and direct Zur targets in Yersinia pestis

    Directory of Open Access Journals (Sweden)

    Wang Xiaoyi

    2009-06-01

    Full Text Available Abstract Background The zinc uptake regulator Zur is a Zn2+-sensing metalloregulatory protein involved in the maintenance of bacterial zinc homeostasis. Up to now, regulation of zinc homeostasis by Zur is poorly understood in Y. pestis. Results We constructed a zur null mutant of Y. pestis biovar microtus strain 201. Microarray expression analysis disclosed a set of 154 Zur-dependent genes of Y. pestis upon exposure to zinc rich condition. Real-time reverse transcription (RT-PCR was subsequently used to validate the microarray data. Based on the 154 Zur-dependent genes, predicted regulatory Zur motifs were used to screen for potential direct Zur targets including three putative operons znuA, znuCB and ykgM-RpmJ2. The LacZ reporter fusion analysis verified that Zur greatly repressed the promoter activity of the above three operons. The subsequent electrophoretic mobility shift assay (EMSA demonstrated that a purified Zur protein was able to bind to the promoter regions of the above three operons. The DNase I footprinting was used to identify the Zur binding sites for the above three operons, verifying the Zur box sequence as predicted previously in γ-Proteobacteria. The primer extension assay was further used to determine the transcription start sites for the above three operons and to localize the -10 and -35 elements. Zur binding sites overlapped the -10 sequence of its target promoters, which was consistent with the previous observation that Zur binding would block the entry of the RNA polymerase to repress the transcription of its target genes. Conclusion Zur as a repressor directly controls the transcription of znuA, znuCB and ykgM-RpmJ2 in Y. pestis by employing a conserved mechanism of Zur-promoter DNA association as observed in γ-Proteobacteria. Zur contributes to zinc homeostasis in Y. pestis likely through transcriptional repression of the high-affinity zinc uptake system ZnuACB and two alternative ribosomal proteins YkgM and RpmJ2.

  20. Optimization of Design of Steam Turbine Exhaust Conduits

    Directory of Open Access Journals (Sweden)

    A. S. Goldin

    2014-01-01

    Full Text Available Improving effectiveness turbine was and remains a key issue for today. In order to improve the efficiency of the turbine is necessary to reduce losses in the steam turbine exhaust conduit.This paper presents the design optimization exhaust conduit steam turbine K-27-2.9 produced by JSC «KTW» at the design stage. The aims of optimizing the design were: decreasing hydraulic resistance of the conduit, reduction of non-uniformity of the flow at the outlet of the conduit, equalizing steam flow ahead of the condenser tube bundle.The conduit models were made and flows in it were simulated in environment of the Solid Works and its application COSMOS Flo Works.As the initial conduit model was selected exhaust conduit of turbine PT-25/34-3.4 produced by JSC «KTW». Was obtained by the calculated velocity field at the outlet of the conduit. The analysis of the calculation results revealed the necessity of changes to the initial design of the conduit. The changes were accompanied by calculating currents flow in the conduit, and assessed the impact of design changes on the nature of the course. Further transformation of the construction of the conduit was held on the results of these calculations. Construction changes are not touched by the outer geometry of the conduit, and were introduced to meet technological.According to calculation results, conclusions were drawn and selected three versions of the conduit.Given are the research results for the initial conduit model and modified design versions. In order to evaluate the flow degree of irregularity the momentum factor (Bussinesku factor for outlet crosssection of the selected conduit design version. Analysis of the research results made it possible to determine optimum design of the exhaust conduit.Introducing the suggested alterations in the conduit design will result in improvement of heat exchange in the condenser, an increase in reliability of the tube bundle operation, a decrease in noise and

  1. SQUG cable tray and conduit evaluation procedure

    International Nuclear Information System (INIS)

    Smith, P.D.; Eder, S.J.; Conoscente, J.P.

    1990-01-01

    Cable tray and conduit systems for electrical cables are a common feature and industrial facilities. They have an excellent performance history in past strong earthquake, even though they are rarely designed for earthquakes. Considerable data have been gathered on their performance in earthquakes and in shake table testing. The data have been used to develop a procedure for the verification of the seismic adequacy of cable tray and conduit systems in operating nuclear plants. The procedure is discussed in this paper. It will result in substantial savings, such as reduced engineering effort, fewer modifications of existing hardware, and simpler documentation, relative to alternate procedures like dynamic analysis of shake table testing. The procedure ensures safety-function in a unique manner since the methodology used to develop it (1) is based on a large body of historical data and (2) uses a relative approach of ensuring that nuclear plant systems will perform at least as well as systems that performed well in past earthquakes. (orig.)

  2. LOAD ON BURIED PRESSURE CONDUITS WITH REFERENCE TO ...

    African Journals Online (AJOL)

    width of conduit or trench; the shearing forces on the plane between the backfill and adjacent earth; for embankment condition, the amounL of relative settlement between the backfill and adjacent earth; the rigidity of the conduit support under embankment loading. Table 3. Selected values of c'' for use in Eq. 8. Sand and.

  3. Water Flow in Karst Aquifer Considering Dynamically Variable Saturation Conduit

    Science.gov (United States)

    Tan, Chaoqun; Hu, Bill X.

    2017-04-01

    The karst system is generally conceptualized as dual-porosity system, which is characterized by low conductivity and high storage continuum matrix and high conductivity and quick flow conduit networks. And so far, a common numerical model for simulating flow in karst aquifer is MODFLOW2005-CFP, which is released by USGS in 2008. However, the steady-state approach for conduit flow in CFP is physically impractical when simulating very dynamic hydraulics with variable saturation conduit. So, we adopt the method proposed by Reimann et al. (2011) to improve current model, in which Saint-Venant equations are used to model the flow in conduit. Considering the actual background that the conduit is very big and varies along flow path and the Dirichlet boundary varies with rainfall in our study area in Southwest China, we further investigate the influence of conduit diameter and outflow boundary on numerical model. And we also analyze the hydraulic process in multi-precipitation events. We find that the numerical model here corresponds well with CFP for saturated conduit, and it could depict the interaction between matrix and conduit during very dynamic hydraulics pretty well compare with CFP.

  4. How to quantify conduits in wood?

    Science.gov (United States)

    Scholz, Alexander; Klepsch, Matthias; Karimi, Zohreh; Jansen, Steven

    2013-01-01

    Vessels and tracheids represent the most important xylem cells with respect to long distance water transport in plants. Wood anatomical studies frequently provide several quantitative details of these cells, such as vessel diameter, vessel density, vessel element length, and tracheid length, while important information on the three dimensional structure of the hydraulic network is not considered. This paper aims to provide an overview of various techniques, although there is no standard protocol to quantify conduits due to high anatomical variation and a wide range of techniques available. Despite recent progress in image analysis programs and automated methods for measuring cell dimensions, density, and spatial distribution, various characters remain time-consuming and tedious. Quantification of vessels and tracheids is not only important to better understand functional adaptations of tracheary elements to environment parameters, but will also be essential for linking wood anatomy with other fields such as wood development, xylem physiology, palaeobotany, and dendrochronology.

  5. Magma wagging and whirling in volcanic conduits

    Science.gov (United States)

    Liao, Yang; Bercovici, David; Jellinek, Mark

    2018-02-01

    Seismic tremor characterized by 0.5-7 Hz ground oscillations commonly occur before and during eruptions at silicic volcanoes with widely ranging vent geometries and edifice structures. The ubiquitous characteristics of this tremor imply that its causes are potentially common to silicic volcanoes. Here we revisit and extend to three dimensions the magma-wagging model for tremor (Jellinek and Bercovici, 2011; Bercovici et al., 2013), wherein a stiff magma column rising in a vertical conduit oscillates against a surrounding foamy annulus of bubbly magma, giving rise to tremor. While prior studies were restricted to two-dimensional lateral oscillations, here we explore three-dimensional motion and additional modes of oscillations. In the absence of viscous damping, the magma column undergoes 'whirling' motion: the center of each horizontal section of the column traces an elliptical trajectory. In the presence of viscous effect we identify new 'coiling' and 'uncoiling' column bending shapes with relatively higher and comparable rates of dissipation to the original two-dimensional magma wagging model. We also calculate the seismic P-wave response of the crustal material around the volcanic conduit to the new whirling motions and propose seismic diagnostics for different wagging patterns using the time-lag between seismic stations. We test our model by analyzing pre-eruptive seismic data from the 2009 eruption of Redoubt Volcano. In addition to suggesting that the occurrence of elliptical whirling motion more than 1 week before the eruption, our analysis of seismic time-lags also implies that the 2009 eruption was accompanied by qualitative changes in the magma wagging behavior including fluctuations in eccentricity and a reversal in the direction of elliptical whirling motion when the eruption was immediately impending.

  6. Der Weg von der Computerkompetenz zur Medienkompetenz

    Directory of Open Access Journals (Sweden)

    Barbara Zuliani

    2011-09-01

    Full Text Available Weiterführende Gedanken zur „Schlüsselkompetenz Nr.4“ des Europäischen Rates im Bereich des lebenslangen Lernens: Computerkompetenz bzw. Medienkompetenz, sowie Anwendungsbeispiele aus dem Bereich der Volksschule: Klassenblog und verschiedener Apps via iPad - 2 Praxisberichte

  7. Wege zur Entdeckung von Communities in Folksonomies

    OpenAIRE

    Jäschke, Robert; Hotho, Andreas; Schmitz, Christoph; Stumme, Gerd

    2006-01-01

    Ein wichtiger Baustein des neu entdeckten World Wide Web - des "Web 2.0" - stellen Folksonomies dar. In diesen Systemen können Benutzer gemeinsam Ressourcen verwalten und mit Schlagwörtern versehen. Die dadurch entstehenden begrifflichen Strukturen stellen ein interessantes Forschungsfeld dar. Dieser Artikel untersucht Ansätze und Wege zur Entdeckung und Strukturierung von Nutzergruppen ("Communities") in Folksonomies.

  8. Reverse Saphenous Conduit Flap in 19 Dogs and 1 Cat.

    Science.gov (United States)

    Cavalcanti, Jacqueline V J; Barry, Sabrina L; Lanz, Otto I; Barnes, Katherine; Coutin, Julia V

    2018-05-14

    The purpose of this retrospective study was to report the outcomes of 19 dogs and 1 cat undergoing reverse saphenous conduit flap between 1999 and 2016. Reverse saphenous conduit flap was used to treat traumatic wounds and wounds resulting from tumor excision in the hind limb; the majority of cases had medial shearing injuries. All animals had complete flap survival. In five animals (20%), minor donor site dehiscence occurred, which did not require surgery. Other postoperative complications included signs of severe venous congestion in one dog. Reverse saphenous conduit flap is a useful technique to repair skin defects of the distal hind limb.

  9. Biological conduit small gap sleeve bridging method for peripheral nerve injury: regeneration law of nerve fibers in the conduit

    Directory of Open Access Journals (Sweden)

    Pei-xun Zhang

    2015-01-01

    Full Text Available The clinical effects of 2-mm small gap sleeve bridging of the biological conduit to repair peripheral nerve injury are better than in the traditional epineurium suture, so it is possible to replace the epineurium suture in the treatment of peripheral nerve injury. This study sought to identify the regeneration law of nerve fibers in the biological conduit. A nerve regeneration chamber was constructed in models of sciatic nerve injury using 2-mm small gap sleeve bridging of a biodegradable biological conduit. The results showed that the biological conduit had good histocompatibility. Tissue and cell apoptosis in the conduit apparently lessened, and regenerating nerve fibers were common. The degeneration regeneration law of Schwann cells and axons in the conduit was quite different from that in traditional epineurium suture. During the prime period for nerve fiber regeneration (2-8 weeks, the number of Schwann cells and nerve fibers was higher in both proximal and distal ends, and the effects of the small gap sleeve bridging method were better than those of the traditional epineurium suture. The above results provide an objective and reliable theoretical basis for the clinical application of the biological conduit small gap sleeve bridging method to repair peripheral nerve injury.

  10. Ein Beitrag zur Blutzellmorphologie ausgewählter karnivorer Zootierarten

    OpenAIRE

    Güth, Henrike

    2004-01-01

    Henrike Güth Ein Beitrag zur Blutzellmorphologie ausgewählter karnivorer Zootierarten Zoo Leipzig Januar 2003 156 Seiten, 222 Abbildungen, 67 Tabellen, 1 Graphik, 151 Literaturangaben, Anhang mit 25 Abbildungen und 6 Tabellen Zur Beurteilung des Blutbildes ist es nötig, neben der quantitativen Betrachtung der Blutzellen auch ihre Morphologie in die Untersuchungen einzubeziehen. In der Praxis werden dazu häufig nach May-Grünwald-Giemsa-gefärbte Ausstriche verwendet. Referenzwerte zur physiolog...

  11. 26 CFR 1.7701(l)-1 - Conduit financing arrangements.

    Science.gov (United States)

    2010-04-01

    ... determines that such recharacterization is appropriate to prevent avoidance of any tax imposed by title 26 of...) INCOME TAX (CONTINUED) INCOME TAXES General Actuarial Valuations § 1.7701(l)-1 Conduit financing...

  12. Artificial urinary conduit construction using tissue engineering methods.

    Science.gov (United States)

    Kloskowski, Tomasz; Pokrywczyńska, Marta; Drewa, Tomasz

    2015-01-01

    Incontinent urinary diversion using an ileal conduit is the most popular method used by urologists after bladder cystectomy resulting from muscle invasive bladder cancer. The use of gastrointestinal tissue is related to a series of complications with the necessity of surgical procedure extension which increases the time of surgery. Regenerative medicine together with tissue engineering techniques gives hope for artificial urinary conduit construction de novo without affecting the ileum. In this review we analyzed history of urinary diversion together with current attempts in urinary conduit construction using tissue engineering methods. Based on literature and our own experience we presented future perspectives related to the artificial urinary conduit construction. A small number of papers in the field of tissue engineered urinary conduit construction indicates that this topic requires more attention. Three main factors can be distinguished to resolve this topic: proper scaffold construction along with proper regeneration of both the urothelium and smooth muscle layers. Artificial urinary conduit has a great chance to become the first commercially available product in urology constructed by regenerative medicine methods.

  13. Sie lebt! Zur Verbraucherforschung im deutschsprachigen Raum

    DEFF Research Database (Denmark)

    Oehler, Andreas; Reisch, Lucia

    2012-01-01

    jeweils eine existierende Aktivität; eine deutliche Lücke, die es zu schließen gilt (Wachstumsfelder der Verbraucherforschung). Zur Finanzierung der Verbraucherforschung ergibt sich der deutliche Befund, dass mit weitem Abstand die „Bordmittel“ der jeweiligen Professur bzw. des jeweiligen Lehrstuhls als...... oder des BMELV darauf hindeuten, dass die Verbraucherforschung zunehmend als wichtiges Element oder gar als Voraussetzung für eine fundierte moderne Verbraucherpolitik gesehen wird....

  14. Wohnquartiersbeschreibung: ein Instrument zur Regionalisierung von Nachbarschaften

    OpenAIRE

    Hoffmeyer-Zlotnik, Jürgen H. P.

    2001-01-01

    'Ausgehend von der Annahme, daß soziale Differenzierung sich in räumlicher Differenzierung niederschlägt, bietet eine Beschreibung der Struktur des näheren Wohnumfeldes die Möglichkeit, das Wohnquartier als Handlungsraum und Sozialisationsinstanz zur Interpretation von Umfragedaten zu nutzen. Das vorliegende Instrumentarium erlaubt es, das Wohnquartier unabhängig von Zensusdaten über Merkmale, die in der eigenen Umfrage erhoben werden, zu charakterisieren.' (Autorenreferat) 'The general hy...

  15. Verfahren zur genbasierten Diagnose eines Legasthenierisikos

    OpenAIRE

    Wilcke, Arndt; Ahnert, Peter; Kirsten, Holger; Ligges, Carolin; Boltze, Johannes

    2016-01-01

    Die vorliegende Erfindung betrifft ein Verfahren zur Diagnose eines Legasthenierisikos, umfassend die Schritte: a) Bereitstellung einer Nukleinsäure beinhaltenden Probe von einem zu diagnostizierenden Menschen, b) Bestimmung des Genotyps der Nukleinsäure der Probe für mindestens eine chromosomale Region, ausgewählt aus der Gruppe bestehend aus der Region von Nukleotid 12091000 bis 12200000 des Chromosoms 1, der Region von Nukleotid 89066000 bis 89088000 des Chromosoms 15, der Region von Nukle...

  16. In Vitro Study of Directly Bioprinted Perfusable Vasculature Conduits.

    Science.gov (United States)

    Zhang, Yahui; Yu, Yin; Akkouch, Adil; Dababneh, Amer; Dolati, Farzaneh; Ozbolat, Ibrahim T

    2015-01-01

    The ability to create three dimensional (3D) thick tissues is still a major tissue engineering challenge. It requires the development of a suitable vascular supply for an efficient media exchange. An integrated vasculature network is particularly needed when building thick functional tissues and/or organs with high metabolic activities, such as the heart, liver and pancreas. In this work, human umbilical vein smooth muscle cells (HUVSMCs) were encapsulated in sodium alginate and printed in the form of vasculature conduits using a coaxial deposition system. Detailed investigations were performed to understand the dehydration, swelling and degradation characteristics of printed conduits. In addition, because perfusional, permeable and mechanical properties are unique characteristics of natural blood vessels, for printed conduits these properties were also explored in this work. The results show that cells encapsulated in conduits had good proliferation activities and that their viability increased during prolonged in vitro culture. Deposition of smooth muscle matrix and collagen was observed around the peripheral and luminal surface in long-term cultured cellular vascular conduit through histology studies.

  17. Ash production by attrition in volcanic conduits and plumes.

    Science.gov (United States)

    Jones, T J; Russell, J K

    2017-07-17

    Tephra deposits result from explosive volcanic eruption and serve as indirect probes into fragmentation processes operating in subsurface volcanic conduits. Primary magmatic fragmentation creates a population of pyroclasts through volatile-driven decompression during conduit ascent. In this study, we explore the role that secondary fragmentation, specifically attrition, has in transforming primary pyroclasts upon transport in volcanic conduits and plumes. We utilize total grain size distributions from a suite of natural and experimentally produced tephra to show that attrition is likely to occur in all explosive volcanic eruptions. Our experimental results indicate that fine ash production and surface area generation is fast (eruption column stability, tephra dispersal, aggregation, volcanic lightening generation, and has concomitant effects on aviation safety and Earth's climate.

  18. Wässrige Nanosuspensionen zur pulmonalen Applikation

    OpenAIRE

    Scherließ, Holger

    2008-01-01

    Im Rahmen der vorliegenden Arbeit wurde die Entwicklung einer Nanosuspensionsformulierung zur inhalativen Anwendung mit dem schwerlöslichen Antimykotikum Itraconazol untersucht. Viele der neu entwickelten pharmazeutischen Wirkstoffe sind nach der Arzneibuchdefinition als schwerlöslich, sehr schwer löslich oder gar praktisch unlöslich einzuteilen. Das bedingt in der Praxis häufig Probleme in der Bioverfügbarkeit und stellt eine große Herausforderung für die Galenik dar. Die Herstellung der Nan...

  19. Untersuchungen zur Genauigkeit digitaler intraoraler Scans

    OpenAIRE

    Benedickt, Christopher Roland

    2017-01-01

    Ziel der hier vorliegenden In-vitro-Studie war es, zu untersuchen, ob es bei digitalen int-raoralen Scans zu Verzerrungen, Streckungen, Stauchungen, Verdrillungen oder Biegun-gen, kommt. Als Prüfmodell diente ein vollbezahntes Oberkiefermodell aus einer Chrom-Kobalt-Molybdän-Legierung. Auf diesem waren die Zähne 11, 15, 24 und 26 zur Auf-nahme eines Veneers, einer Vollkrone, eines Inlays präpariert, und auf inzisalen bezie-hungsweise okklusalen Mulden der Zähne 13, 23, 17 und 27 waren Metallk...

  20. Design of barrier coatings on kink-resistant peripheral nerve conduits

    Directory of Open Access Journals (Sweden)

    Basak Acan Clements

    2016-02-01

    Full Text Available Here, we report on the design of braided peripheral nerve conduits with barrier coatings. Braiding of extruded polymer fibers generates nerve conduits with excellent mechanical properties, high flexibility, and significant kink-resistance. However, braiding also results in variable levels of porosity in the conduit wall, which can lead to the infiltration of fibrous tissue into the interior of the conduit. This problem can be controlled by the application of secondary barrier coatings. Using a critical size defect in a rat sciatic nerve model, the importance of controlling the porosity of the nerve conduit walls was explored. Braided conduits without barrier coatings allowed cellular infiltration that limited nerve recovery. Several types of secondary barrier coatings were tested in animal studies, including (1 electrospinning a layer of polymer fibers onto the surface of the conduit and (2 coating the conduit with a cross-linked hyaluronic acid-based hydrogel. Sixteen weeks after implantation, hyaluronic acid-coated conduits had higher axonal density, displayed higher muscle weight, and better electrophysiological signal recovery than uncoated conduits or conduits having an electrospun layer of polymer fibers. This study indicates that braiding is a promising method of fabrication to improve the mechanical properties of peripheral nerve conduits and demonstrates the need to control the porosity of the conduit wall to optimize functional nerve recovery.

  1. Free-boundary models of a meltwater conduit

    KAUST Repository

    Dallaston, Michael C.; Hewitt, Ian J.

    2014-01-01

    © 2014 AIP Publishing LLC. We analyse the cross-sectional evolution of an englacial meltwater conduit that contracts due to inward creep of the surrounding ice and expands due to melting. Making use of theoretical methods from free-boundary problems

  2. Development of a comprehensive inventory management system for underground fiber optic conduits.

    Science.gov (United States)

    2013-03-01

    Major State Departments of Transportation operate and maintain networks of thousands of miles of conduits, many : carrying fiber optic cables that are vital to State communication systems. These conduits are located alongside or : across highways and...

  3. POROSITY OF THE WALL OF A NEUROLAC (R) NERVE CONDUIT HAMPERS NERVE REGENERATION

    NARCIS (Netherlands)

    Meek, Marcel F.; Den Dunnen, Wilfred F. A.

    2009-01-01

    One way to improve nerve regeneration and bridge longer nerve gaps may be the use of semipermeable/porous conduits. With porosity less biomaterial is used for the nerve conduit. We evaluated the short-term effects of porous Neurolac (R) nerve conduits for in vivo peripheral nerve regeneration. In 10

  4. Untersuchungen zur Rauchgasentstickung mittels Schwefelwasserstoff in Tri-n-butylphosphat

    OpenAIRE

    Homann, Jörg

    2000-01-01

    In der vorliegenden Arbeit wurde die Reaktion von Stickstoffmonoxid (NO) mit Schwefelwassersoff (H2S) in Tri-n-butylphosphat (TBP) im Hinblick auf ein alternatives Verfahren zur Entstickung von Rauchgasen untersucht. Mittels einer gasvolumetrischen Absorptionsapparatur wurden zuerst Daten zur physikalischen Löslichkeit in TBP ermittelt, die für den Erhalt kinetischer Daten der stofftransportüberlagerten Reaktionen in TBP relevant sind. Es sind dies die Henrykoeffizienten von NO, H2S und die d...

  5. Frictional melting and stick-slip behavior in volcanic conduits

    Science.gov (United States)

    Kendrick, Jackie Evan; Lavallee, Yan; Hirose, Takehiro; di Toro, Giulio; Hornby, Adrian Jakob; Hess, Kai-Uwe; Dingwell, Donald Bruce

    2013-04-01

    Dome-building eruptions have catastrophic potential, with dome collapse leading to devastating pyroclastic flows with almost no precursory warning. During dome growth, the driving forces of the buoyant magma may be superseded by controls along conduit margins; where brittle fracture and sliding can lead to formation of lubricating cataclasite and gouge. Under extreme friction, pseudotachylyte may form at the conduit margin. Understanding the conduit margin processes is vital to understanding the continuation of an eruption and we postulate that pseudotachylyte generation could be the underlying cause of stick-slip motion and associated seismic "drumbeats", which are so commonly observed at dome-building volcanoes. This view is supported by field evidence in the form of pseudotachylytes identified in lava dome products at Soufrière Hills (Montserrat) and Mount St. Helens (USA). Both eruptions were characterised by repetitive, periodic seismicity and lava spine extrusion of highly viscous magma. High velocity rotary shear (HVR) experiments demonstrate the propensity for melting of the andesitic and dacitic material (from Soufrière Hills and Mount St. Helens respectively) at upper conduit stress conditions (HVR experiments which mimic rapid velocity fluctuations in stick-slip behavior demonstrate velocity-weakening behavior of melt, with a tendency for unstable slip. During ascent, magma may slip and undergo melting along the conduit margin. In the process the shear resistance of the slip zone is increased, acting as a viscous brake halting slip (the "stick" of stick-slip motion). Sufficient buoyancy-driven pressures from ascending magma below eventually overcome resistance to produce a rapid slip event (the "slip") along the melt-bearing slip zone, which is temporarily lubricated due to velocity-weakening. New magma below experiences the same slip event more slowly (as the magma decompresses) to produce a viscous brake and the process is repeated. This allows a

  6. Biocarbon urinary conduit: laboratory experience and clinical applications.

    Science.gov (United States)

    Kobashi, L I; Raible, D A

    1980-07-01

    A new urinary conduit utilizing pure vitreous carbon has been used successfully in dogs. Pure carbon appears to be inert with respect to urine and urothelium. Lack of urinary salt encrustation on the exposed surface provides a well-functioning urinary conduit for vesical drainage. Twenty-one vesicostomies were performed in dogs. Careful follow-up and histologic studies of removed specimens were done to establish the biocompatibility of pure carbon. All vesicostomies functioned well. A description of the device, protocol, and results of laboratory experimentation are outlined. The surgical procedure is explained in detail. Results encourage the clinical trial of these devices in humans. Indications include patients with neurogenic vesicla dysfunction and those with total urinary incontinence, both of which require permanent indwelling catheters.

  7. Tension layer winding of cable-in-conduit conductor

    International Nuclear Information System (INIS)

    Devernoe, A.; Ciancetta, G.; King, M.; Parizh, M.; Painter, T.; Miller, J.

    1996-01-01

    A 710 mm i.d. by 440 mm long, 6 layer Cable-in-Conduit (CIC) coil was precision tension layer wound with Incoloy 908 jacketed conductor to model winding technology that will be used for the Nb 3 Sn outsert coils of the 45 Tesla Hybrid Magnet Project at the US National High Magnetic Field Laboratory. This paper reports on the set up of a new winding facility with unique capabilities for insulating and winding long length CIC conductor and on special procedures which were developed to wind and support layer to layer transitions and to safely form conductor into and out of the winding. Analytical methods used to predict conduit keystoning, springback and back tensioning requirements before winding are reported in comparison to results obtained during winding and actual winding build-up dimensions on a layer by layer basis in comparison to design requirements

  8. Erosion of cohesive soil layers above underground conduits

    Directory of Open Access Journals (Sweden)

    Luu Li-Hua

    2017-01-01

    Full Text Available Using a recently developed 2D numerical modelling that combines Discrete Element (DEM and Lattice Boltzmann methods (LBM, we simulate the destabilisation by an hydraulic gradient of a cohesive granular soil clogging the top of an underground conduit. We aim to perform a multi-scale study that relates the grain scale behavior to the macroscopic erosion process. In particular, we study the influence of the flow conditions and the inter-particle contact forces intensity on the erosion kinetic.

  9. Erosion of cohesive soil layers above underground conduits

    Science.gov (United States)

    Luu, Li-Hua; Philippe, Pierre; Noury, Gildas; Perrin, Jérôme; Brivois, Olivier

    2017-06-01

    Using a recently developed 2D numerical modelling that combines Discrete Element (DEM) and Lattice Boltzmann methods (LBM), we simulate the destabilisation by an hydraulic gradient of a cohesive granular soil clogging the top of an underground conduit. We aim to perform a multi-scale study that relates the grain scale behavior to the macroscopic erosion process. In particular, we study the influence of the flow conditions and the inter-particle contact forces intensity on the erosion kinetic.

  10. CIBLAGE D'INFLATION ET CONDUITE DE LA POLITIQUE ...

    African Journals Online (AJOL)

    Administrateur

    de l'amendement de la loi relative à la monnaie et au crédit, l'Algérie a explicitement ... la Banque d'Algérie, très importante pour la conduite de la politique monétaire. ..... matière de contrainte budgétaire entre les secteurs public et privé. En.

  11. Explosive device of conduit using Ti Ni alloy

    Directory of Open Access Journals (Sweden)

    A. Yu. Kolobov

    2014-01-01

    Full Text Available Presently, materials have been developed which are capable at changing temperate to return significant inelastic deformations, exhibit rubber-like elasticity, convert heat into mechanical work, etc. The aggregate of these effects is usually called the shape memory effect.At present a great number of compounds and alloys with a shape memory effect has been known.These are alloys based on titanium nickelide (TiNi, copper-based alloys (Cu-Al, Cu-Sn, Cu-Al-Ni, Cu-Zn-Si, etc., gold and silver (Ag-Cd, Au-Ag-Cd, Au-Cd-Cu, Au-Zn-Cu, etc., manganese (Mn-Cr, Fe-Cu, Mn-Cu-Ni, Mn-Cu-Zr, Mn-Ni, etc., iron (Fe-Mn, Fe-Ni, Fe-Al, etc., and other compounds.The alloys based on titanium nickelide (nitinol are the most widely used.Alloys with shape memory effect find various applications in engineering and medicine, namely connecting devices, actuators, transformable design, multipurpose medical implants, etc.There is a task of breaking fuel conduit during separating the spacecraft from the rocket in space technology.The paper examines the procedure for design calculation of the separating device of conduit with the use of Ti-Ni alloy. This device can be used instead of the pyro-knives.The device contains two semi-rings from Ti-Ni alloy. In the place of break on the conduit an annular radius groove is made.At a temperature of martensite passage the semi-rings undergo deformation and in the strained state are set in the device. With heating to the temperature of the austenitic passage of bushing macro-deformation the energy stored by the nitinol bushing is great enough to break the conduit on the neck.The procedures of design calculation and response time of device are given.

  12. Zur interaktionistischen Theorie der mediatisierten Kommunikation

    Directory of Open Access Journals (Sweden)

    Ulrich Holefleisch

    2001-03-01

    Full Text Available Nicht nur Fachleute beklagen die mangelnde Qualität der deutschen Filme und Werbespots. Eine Ursache für die mangelnden Erfolge solcher mediatisierten Kommunikation liegt in einer systematischen Interaktionsstörung zwischen der Medienpraxis und Medienforschung. Die aktuelle deutschsprachige Medienwirkungsforschung entzieht sich weitgehend der gebotenen und von Macher/innen erwarteten gesellschafts- und praxisdienenden Aufgabe. Der Hauptgrund hierfür liegt darin, dass die zumeist zugrunde gelegten Forschungsrahmen (conceptual frameworks praxisrelevante Kategorien wie die der Zuschauerperspektive weitgehend ignorieren. Das hier vorgestellte interaktionistische Modell der mediatisierten Kommunikation will deshalb als Forschungsrahmen den Blick auf Übersehenes richten. Darüber hinaus soll dieses Modell auch für Praktiker als Prüfschema zur Mediaplanung dienen, mediatisierte Kommunikation - gemessen am eigenen Anspruch - kalkulierbarer und damit auch erfolgreicher zu machen.

  13. Novel drug delivering conduit for peripheral nerve regeneration

    Science.gov (United States)

    Labroo, Pratima; Shea, Jill; Edwards, Kyle; Ho, Scott; Davis, Brett; Sant, Himanshu; Goodwin, Isak; Gale, Bruce; Agarwal, Jay

    2017-12-01

    Objective. This paper describes the design of a novel drug delivery apparatus integrated with a poly lactic-co-glycolic acid (PLGA) based nerve guide conduit for controlled local delivery of nerve growth factor (NGF) and application in peripheral nerve gap injury. Approach. An NGF dosage curve was acquired to determine the minimum in vitro concentration for optimal neurite outgrowth of dorsal root ganglion (DRG) cells; PLGA based drug delivery devices were then designed and tested in vitro and in vivo across 15 mm rat sciatic nerve gap injury model. Main results. The drug delivery nerve guide was able to release NGF for 28 d at concentrations (0.1-10 ng ml-1) that were shown to enhance DRG neurite growth. Furthermore, the released NGF was bioactive and able to enhance DRG neurite growth. Following these tests, optimized NGF-releasing nerve conduits were implanted across 15 mm sciatic nerve gaps in a rat model, where they demonstrated significant myelination and muscle innervation in vivo as compared to empty nerve conduits (p  design process and provides increased versatility for releasing a variety of different growth factors. This innovative device has the potential for broad applicability and allows for easier customization to change the type of drugs and dosage of individual drugs without devising a completely new biomaterial-drug conjugate each time.

  14. Free-boundary models of a meltwater conduit

    KAUST Repository

    Dallaston, Michael C.

    2014-08-01

    © 2014 AIP Publishing LLC. We analyse the cross-sectional evolution of an englacial meltwater conduit that contracts due to inward creep of the surrounding ice and expands due to melting. Making use of theoretical methods from free-boundary problems in Stokes flow and Hele-Shaw squeeze flow we construct an exact solution to the coupled problem of external viscous creep and internal heating, in which we adopt a Newtonian approximation for ice flow and an idealized uniform heat source in the conduit. This problem provides an interesting variant on standard free-boundary problems, coupling different internal and external problems through the kinematic condition at the interface. The boundary in the exact solution takes the form of an ellipse that may contract or expand (depending on the magnitudes of effective pressure and heating rate) around fixed focal points. Linear stability analysis reveals that without the melting this solution is unstable to perturbations in the shape. Melting can stabilize the interface unless the aspect ratio is too small; in that case, instabilities grow largest at the thin ends of the ellipse. The predictions are corroborated with numerical solutions using boundary integral techniques. Finally, a number of extensions to the idealized model are considered, showing that a contracting circular conduit is unstable to all modes of perturbation if melting occurs at a uniform rate around the boundary, or if the ice is modelled as a shear-thinning fluid.

  15. Mechanical cleaning of oil spills in seawater using circular conduits

    Energy Technology Data Exchange (ETDEWEB)

    Shedid, S.; Abou Kassem, J.; Zekri, A. [United Arab Emirates Univ., Al Ain City (United Arab Emirates). Dept. of Chemical and Petroleum Engineering

    2005-10-15

    Treatment of the crude oil pollution in seawater has attracted global attention during the last two decades. This study was undertaken using circular conduits as a mechanical means to clean oil spills in seawater under different conditions of temperature, oil gravity, shaking frequency, conduit diameter, and initial thickness of oil layer. An experimental model was designed and built to achieve the study. It consists of shaking water bath (to represent sea waves) fitted with temperature controller and glass tubes of different inside diameters of 0.3 cm, 0.5 cm, and 0.7 cm. Three crude oils of different oil gravity of 35{sup o}API, 38{sup o}API, and 47{sup o}API were investigated under different shaking frequencies of 20, 40, and 60 stroke/minute with different tube diameters. The results proved that application of mechanical cleaning of oil spills using circular conduits is a practical technique. The cleaning of black oil spills is more efficient than one of volatile oil. Furthermore, the results indicated that the increase of shaking frequency and/or water temperature provide(s) faster cleaning of oil spills while temperature increase recovers the maximum oil. (Author)

  16. Peripheral nerve regeneration with conduits: use of vein tubes.

    Science.gov (United States)

    Sabongi, Rodrigo Guerra; Fernandes, Marcela; Dos Santos, João Baptista Gomes

    2015-04-01

    Treatment of peripheral nerve injuries remains a challenge to modern medicine due to the complexity of the neurobiological nerve regenerating process. There is a greater challenge when the transected nerve ends are not amenable to primary end-to-end tensionless neurorraphy. When facing a segmental nerve defect, great effort has been made to develop an alternative to the autologous nerve graft in order to circumvent morbidity at donor site, such as neuroma formation, scarring and permanent loss of function. Tubolization techniques have been developed to bridge nerve gaps and have been extensively studied in numerous experimental and clinical trials. The use of a conduit intends to act as a vehicle for moderation and modulation of the cellular and molecular ambience for nerve regeneration. Among several conduits, vein tubes were validated for clinical application with improving outcomes over the years. This article aims to address the investigation and treatment of segmental nerve injury and draw the current panorama on the use of vein tubes as an autogenous nerve conduit.

  17. Peripheral nerve regeneration with conduits: use of vein tubes

    Directory of Open Access Journals (Sweden)

    Rodrigo Guerra Sabongi

    2015-01-01

    Full Text Available Treatment of peripheral nerve injuries remains a challenge to modern medicine due to the complexity of the neurobiological nerve regenerating process. There is a greater challenge when the transected nerve ends are not amenable to primary end-to-end tensionless neurorraphy. When facing a segmental nerve defect, great effort has been made to develop an alternative to the autologous nerve graft in order to circumvent morbidity at donor site, such as neuroma formation, scarring and permanent loss of function. Tubolization techniques have been developed to bridge nerve gaps and have been extensively studied in numerous experimental and clinical trials. The use of a conduit intends to act as a vehicle for moderation and modulation of the cellular and molecular ambience for nerve regeneration. Among several conduits, vein tubes were validated for clinical application with improving outcomes over the years. This article aims to address the investigation and treatment of segmental nerve injury and draw the current panorama on the use of vein tubes as an autogenous nerve conduit.

  18. Parastomal hernias after radical cystectomy and ileal conduit diversion

    Directory of Open Access Journals (Sweden)

    Timothy F. Donahue

    2016-07-01

    Full Text Available Parastomal hernia, defined as an “incisional hernia related to an abdominal wall stoma”, is a frequent complication after conduit urinary diversion that can negatively impact quality of life and present a clinically significant problem for many patients. Parastomal hernia (PH rates may be as high as 65% and while many patients are asymptomatic, in some series up to 30% of patients require surgical intervention due to pain, leakage, ostomy appliance problems, urinary obstruction, and rarely bowel obstruction or strangulation. Local tissue repair, stoma relocation, and mesh repairs have been performed to correct PH, however, long-term results have been disappointing with recurrence rates of 30%–76% reported after these techniques. Due to high recurrence rates and the potential morbidity of PH repair, efforts have been made to prevent PH development at the time of the initial surgery. Randomized trials of circumstomal prophylactic mesh placement at the time of colostomy and ileostomy stoma formation have shown significant reductions in PH rates with acceptably low complication profiles. We have placed prophylactic mesh at the time of ileal conduit creation in patients at high risk for PH development and found it to be safe and effective in reducing the PH rates over the short-term. In this review, we describe the clinical and radiographic definitions of PH, the clinical impact and risk factors associated with its development, and the use of prophylactic mesh placement for patients undergoing ileal conduit urinary diversion with the intent of reducing PH rates.

  19. Pseudotachylyte formation in volcanic conduits: Montserrat vs. Mount St. Helens

    Science.gov (United States)

    Kendrick, J. E.; Lavallee, Y.; Petrakova, L.; Ferk, A.; Di Toro, G.; Hess, K.; Ferri, F.; Dingwell, D. B.

    2012-12-01

    Seismogenic fracture and faulting may result in non-equilibrium frictional melting of rock, which upon cooling and recrystallisation forms pseudotachylyte. In volcanic environments, the transition from endogenous to exogenous growth can be attributed to a shift in magma rheology into the brittle regime, and thus the ascent of high-viscosity magma can form discrete shear zones, comparable to tectonic faults, along conduit margins. Pseudotachylytes have, until now, rarely been noted in exogenous volcanic materials and seldom in active volcanic environments. This is despite the simultaneous occurrence of high pressures and differential stresses, which make high-viscosity magmas ideal candidates for the occurrence of frictional melting. Here, we compare the chemical, thermal, magnetic and structural properties of two candidate volcanic pseudotachylytes; one from Soufriere Hills (Montserrat) and one from Mount St. Helens (USA). Additionally, we present data from a set of high-velocity rotary shear experiments on the host materials of these natural pseudotachylytes in which melting was induced after just 10's of centimeters of slip at realistic extrusion velocities (0.4 - 1.6 ms-1) and low normal stresses (0.5-2 MPa). After 1-2 meters of slip a continuous melt layer formed, at which point friction decreased and the fault zone displayed slip-weakening behaviour. For volcanic conduits, this would facilitate temporarily elevated slip rates, or an increase in extrusion rate, and could cause transitions in dome morphology and eruption style. This study demonstrates that shear fracturing in magma or sliding along conduit margins can readily result in frictional melting. The conspicuous absence of pseudotachylytes in active volcanic environments is likely the result of exceptionally high background temperatures which precipitate near-equilibrium melting, thereby obviating one of the characteristic signatures of pseudotachylyte - glassy protomelts formed by selective melting of

  20. Geometry and Hydraulics of Englacial Conduits, Storglaciaren, Sweden

    Science.gov (United States)

    Fountain, A. G.; Schlichting, R.; Frodin, S.; Jacobel, R. W.

    2001-12-01

    Englacial conduits are the primary structure responsible for transporting surface water to the base of a glacier, where it supplies the subglacial hydraulic system and, in turn, affects glacier movement. Despite the well-known theoretical descriptions of englacial conduits, little direct evidence exists about their geometry and hydraulics. In July 2001, we initiated a field effort on Storglaciären, Sweden, to intersect englacial conduits by drilling into the glacier using a hot water drill. A companion project (Jacobel et al., this session) attempted to detect the englacial conduits using ground-penetrating radar. In a typical borehole, the water level remained at the surface while drilling through the impermeable ice. Once a connection was made, the water level dropped roughly 10 m and remained low despite continued water pumping. A small video camera was lowered, with attachments, to measure the geometry of the opening, and water flow speed. The water level in the hole provided a piezometric measure of the pressure. We drilled 22 holes at 3 separate locations and 17 (77%) connected englacially, the remaining 5 reached the bed without englacial connection, of which 2 drained at the bed. The geometry of the connections was highly irregular in cross-section with 1-2 cm openings, reminiscent of crevasse-like features rather than circular cross-sections as anticipated from the theoretical literature. Flow behavior was observed by tracking particle motion. The flow was complicated, in part by the inferred tangential intersection between the borehole and structure, and by the observed surging behavior. Flow speeds were low, on the order of 1 cm sec-1. Water level records from 3 different holes over several days exhibited highly correlated variations and large diurnal excursions. In contrast, records from holes drilled to the bed showed little variation. Based on these measurements, our conceptual picture of the englacial system is that of a sluggish flow system

  1. Short-term outcomes after incontinent conduit for gynecologic cancer: comparison of ileal, sigmoid, and transverse colon.

    Science.gov (United States)

    Tabbaa, Zaid M; Janco, Jo Marie T; Mariani, Andrea; Dowdy, Sean C; McGree, Michaela E; Weaver, Amy L; Cliby, William A

    2014-06-01

    The aim of this study is to estimate the overall rates of significant incontinent conduit-related complications and compare rates between conduit types. This was a retrospective review of 166 patients who underwent incontinent urinary diversion from April 1993 through April 2013. Patients were categorized by conduit type-ileal, sigmoid colon, and transverse colon. Significant conduit-related complications were assessed at 30 and 90days after surgery. Significant conduit-related complication was defined as any of the following: ureteral stricture, conduit leak, conduit obstruction, conduit ischemia, ureteral anastomotic leak, stent obstruction requiring intervention via interventional radiology procedure or reoperation, and renal failure. A total of 166 patients underwent formation of an incontinent urinary conduit, most commonly during exenteration for gynecologic malignancy. There were 129 ileal, 11 transverse colon, and 26 sigmoid conduits. The overall significant conduit-related complication rate within 30days was 15.1%. Complication rates for ileal, transverse and sigmoid conduits were 14.7%, 0%, and 23.1%, respectively (Fisher's exact test, p=0.24). By 90days, the Kaplan-Meier estimated rates of significant complications were 21.8% overall, and 22.3%, 0%, and 28.9%, respectively, by conduit type (log-rank test, p=0.19). The most common significant conduit-related complications were conduit or ureteral anastomotic leaks and conduit obstructions. By 1 and 2years following surgery, the Kaplan-Meier estimated overall rate of significant conduit-related complication increased to 26.5% and 30.1%, respectively. Our study suggests that there are multiple appropriate tissue sites for use in incontinent conduit formation, and surgical approach should be individualized. Most significant conduit-related complications occur within 90days after surgery. Copyright © 2014 Elsevier Inc. All rights reserved.

  2. Treatment of right ventricle to pulmonary artery conduit stenosis in infants with hypoplastic left heart syndrome.

    Science.gov (United States)

    Münsterer, Andrea; Kasnar-Samprec, Jelena; Hörer, Jürgen; Cleuziou, Julie; Eicken, Andreas; Malcic, Ivan; Lange, Rüdiger; Schreiber, Christian

    2013-09-01

    To determine the incidence of right ventricle-to-pulmonary artery (RV-PA) conduit stenosis after the Norwood I operation in patients with hypoplastic left heart syndrome (HLHS), and to determine whether the treatment strategy of RV-PA conduit stenosis has an influence on interstage and overall survival. Ninety-six patients had a Norwood operation with RV-PA conduit between 2002 and 2011. Details of reoperations/interventions due to conduit obstruction prior to bidirectional superior cavopulmonary anastomosis (BSCPA) were collected. Overall pre-BSCPA mortality was 17%, early mortality after Norwood, 6%. Early angiography was performed in 34 patients due to desaturation at a median of 8 days after the Norwood operation. Fifteen patients (16%) were diagnosed with RV-PA conduit stenosis that required treatment. The location of the conduit stenosis was significantly different in the patients with non-ringed (proximal) and the patients with ring-enforced conduit (distal), P = 0.004. In 6 patients, a surgical revision of the conduit was performed; 3 of them died prior to BSCPA. Another 6 patients had a stent implantation and 3 were treated with balloon dilatation followed by a BSCPA in the subsequent 2 weeks. All patients who were treated interventionally for RV-PA conduit obstruction had a successful BSCPA. Patients who received a surgical RV-PA conduit revision had a significantly higher interstage (P = 0.044) and overall mortality (P = 0.011) than those who received a stent or balloon dilatation of the stenosis followed by an early BSCPA. RV-PA conduit obstruction after Norwood I procedure in patients with HLHS can be safely and effectively treated by stent implantation, balloon dilatation and early BSCPA. Surgical revision of the RV-PA conduit can be reserved for patients in whom an interventional approach fails, and an early BSCPA is not an option.

  3. Vergleich verschiedener Methoden zur Haftkraftmessung von Dentinadhäsiven

    OpenAIRE

    Schwertner, Katharina

    2010-01-01

    Zur Bestimmung der Haftkraft von Adhäsiven stehen verschiedene Methoden zur Verfügung. Ziel dieser Studie war es, vier gebräuchliche in vitro Haftkraftmessmethoden (Tensile Bond Strength Test, Shear Bond Strength Test, Microtensile Bond Strength Test, Push-out Bond Strength Test) an drei unterschiedlichen Adhäsivsystemen (Syntac, Clearfil SE Bond, Adper Scotchbond Multi Purpose) zu testen und die Ergebnisse zu vergleichen. Die Haftkräfte sind abhängig von der verwendeten Messmethode. Viele Pa...

  4. Digitale Transformation, aber wie? - Von der Spielwiese zur Umsetzungsplanung

    Science.gov (United States)

    Kaiser, Thomas

    Es besteht wohl kaum Anlass zur Annahme, dass die seit Jahrzehnten etablierten Markt- und Technologiestrukturen der Energiewirtschaft sich nicht in einem radikalen Ablöseprozess mit Gewinnern und Verlierern befinden. Aber Vorsicht - vordergründig bereits verloren erscheinende Geschäftsmodelle erfahren im Zuge der Digitalisierung einerseits noch intensiveren Wettbewerbsdruck, können aber andererseits von diesem "technologischen Jungbrunnen" profitieren, um verlorenes Terrain zurückzugewinnen. Im folgenden Kapitel wird ein Managementzyklus aufgezeigt, der in Anlehnung an die bereits erfolgreiche Implementierung digitaler R/Evolutionen anderer Branchen aufzeigt, wie die Geschäftsleitung systematisch kostenbewusst und zielorientiert die Digitalisierung umsetzen kann.

  5. A novel conduit-based coaptation device for primary nerve repair.

    Science.gov (United States)

    Bamba, Ravinder; Riley, D Colton; Kelm, Nathaniel D; Cardwell, Nancy; Pollins, Alonda C; Afshari, Ashkan; Nguyen, Lyly; Dortch, Richard D; Thayer, Wesley P

    2018-06-01

    Conduit-based nerve repairs are commonly used for small nerve gaps, whereas primary repair may be performed if there is no tension on nerve endings. We hypothesize that a conduit-based nerve coaptation device will improve nerve repair outcomes by avoiding sutures at the nerve repair site and utilizing the advantages of a conduit-based repair. The left sciatic nerves of female Sprague-Dawley rats were transected and repaired using a novel conduit-based device. The conduit-based device group was compared to a control group of rats that underwent a standard end-to-end microsurgical repair of the sciatic nerve. Animals underwent behavioral assessments at weekly intervals post-operatively using the sciatic functional index (SFI) test. Animals were sacrificed at four weeks to obtain motor axon counts from immunohistochemistry. A sub-group of animals were sacrificed immediately post repair to obtain MRI images. SFI scores were superior in rats which received conduit-based repairs compared to the control group. Motor axon counts distal to the injury in the device group at four weeks were statistically superior to the control group. MRI tractography was used to demonstrate repair of two nerves using the novel conduit device. A conduit-based nerve coaptation device avoids sutures at the nerve repair site and leads to improved outcomes in a rat model. Conduit-based nerve repair devices have the potential to standardize nerve repairs while improving outcomes.

  6. Evidence for Arbovirus Dissemination Conduits from the Mosquito (Diptera: Culicidae) Midgut

    National Research Council Canada - National Science Library

    Romoser, William

    2004-01-01

    .... Experiments using Venezuelan equine encephalitis viral replicon particles, which express the green fluorescent protein gene in cells, indicate the operation of tissue conduits, possibly involving...

  7. Regenerative potential of silk conduits in repair of peripheral nerve injury in adult rats.

    Science.gov (United States)

    Huang, W; Begum, R; Barber, T; Ibba, V; Tee, N C H; Hussain, M; Arastoo, M; Yang, Q; Robson, L G; Lesage, S; Gheysens, T; Skaer, Nicholas J V; Knight, D P; Priestley, J V

    2012-01-01

    Various attempts have been made to develop artificial conduits for nerve repair, but with limited success. We describe here conduits made from Bombyx mori regenerated silk protein, and containing luminal fibres of Spidrex(®), a silk-based biomaterial with properties similar to those of spider silk. Assessment in vitro demonstrated that Spidrex(®) fibres support neurite outgrowth. For evaluation in vivo, silk conduits 10 mm in length and containing 0, 100, 200 or 300 luminal Spidrex(®) fibres, were implanted to bridge an 8 mm gap in the rat sciatic nerve. At 4 weeks, conduits containing 200 luminal Spidrex(®) fibres (PN200) supported 62% and 59% as much axon growth as autologous nerve graft controls at mid-conduit and distal nerve respectively. Furthermore, Spidrex(®) conduits displayed similar Schwann cell support and macrophage response to controls. At 12 weeks, animals implanted with PN200 conduits showed similar numbers of myelinated axons (81%) to controls, similar gastrocnemius muscle innervation, and similar hindpaw stance assessed by Catwalk footprint analysis. Plantar skin innervation was 73% of that of controls. PN200 Spidrex(®) conduits were also effective at bridging longer (11 and 13 mm) gaps. Our results show that Spidrex(®) conduits promote excellent axonal regeneration and function recovery, and may have potential for clinical application. Copyright © 2011 Elsevier Ltd. All rights reserved.

  8. 3D-engineering of Cellularized Conduits for Peripheral Nerve Regeneration

    Science.gov (United States)

    Hu, Yu; Wu, Yao; Gou, Zhiyuan; Tao, Jie; Zhang, Jiumeng; Liu, Qianqi; Kang, Tianyi; Jiang, Shu; Huang, Siqing; He, Jiankang; Chen, Shaochen; Du, Yanan; Gou, Maling

    2016-08-01

    Tissue engineered conduits have great promise for bridging peripheral nerve defects by providing physical guiding and biological cues. A flexible method for integrating support cells into a conduit with desired architectures is wanted. Here, a 3D-printing technology is adopted to prepare a bio-conduit with designer structures for peripheral nerve regeneration. This bio-conduit is consisted of a cryopolymerized gelatin methacryloyl (cryoGelMA) gel cellularized with adipose-derived stem cells (ASCs). By modeling using 3D-printed “lock and key” moulds, the cryoGelMA gel is structured into conduits with different geometries, such as the designed multichannel or bifurcating and the personalized structures. The cryoGelMA conduit is degradable and could be completely degraded in 2-4 months in vivo. The cryoGelMA scaffold supports the attachment, proliferation and survival of the seeded ASCs, and up-regulates the expression of their neurotrophic factors mRNA in vitro. After implanted in a rat model, the bio-conduit is capable of supporting the re-innervation across a 10 mm sciatic nerve gap, with results close to that of the autografts in terms of functional and histological assessments. The study describes an indirect 3D-printing technology for fabricating cellularized designer conduits for peripheral nerve regeneration, and could lead to the development of future nerve bio-conduits for clinical use.

  9. Convection in a volcanic conduit recorded by bubbles

    Science.gov (United States)

    Carey, Rebecca J.; Manga, Michael; Degruyter, Wim; Gonnermann, Helge M.; Swanson, Donald; Houghton, Bruce F.; Orr, Tim R.; Patrick, Matthew R.

    2013-01-01

    Microtextures of juvenile pyroclasts from Kīlauea’s (Hawai‘i) early A.D. 2008 explosive activity record the velocity and depth of convection within the basaltic magma-filled conduit. We use X-ray microtomography (μXRT) to document the spatial distribution of bubbles. We find small bubbles (radii from 5 μm to 70 μm) in a halo surrounding larger millimeter-size bubbles. This suggests that dissolved water was enriched around the larger bubbles—the opposite of what is expected if bubbles grow as water diffuses into the bubble. Such volatile enrichment implies that the volatiles within the large bubbles were redissolving into the melt as they descended into the conduit by the downward motion of convecting magma within the lava lake. The thickness of the small bubble halo is ∼100–150 μm, consistent with water diffusing into the melt on time scales on the order of 103 s. Eruptions, triggered by rockfall, rapidly exposed this magma to lower pressures, and the haloes of melt with re-dissolved water became sufficiently supersaturated to cause nucleation of the population of smaller bubbles. The required supersaturation pressures are consistent with a depth of a few hundred meters and convection velocities of the order of 0.1 m s−1, similar to the circulation velocity observed on the surface of the Halema‘uma‘u lava lake.

  10. Conduit for high temperature transfer of molten semiconductor crystalline material

    Science.gov (United States)

    Fiegl, George (Inventor); Torbet, Walter (Inventor)

    1983-01-01

    A conduit for high temperature transfer of molten semiconductor crystalline material consists of a composite structure incorporating a quartz transfer tube as the innermost member, with an outer thermally insulating layer designed to serve the dual purposes of minimizing heat losses from the quartz tube and maintaining mechanical strength and rigidity of the conduit at the elevated temperatures encountered. The composite structure ensures that the molten semiconductor material only comes in contact with a material (quartz) with which it is compatible, while the outer layer structure reinforces the quartz tube, which becomes somewhat soft at molten semiconductor temperatures. To further aid in preventing cooling of the molten semiconductor, a distributed, electric resistance heater is in contact with the surface of the quartz tube over most of its length. The quartz tube has short end portions which extend through the surface of the semiconductor melt and which are lef bare of the thermal insulation. The heater is designed to provide an increased heat input per unit area in the region adjacent these end portions.

  11. Exploring Ultimate Water Capillary Evaporation in Nanoscale Conduits.

    Science.gov (United States)

    Li, Yinxiao; Alibakhshi, Mohammad Amin; Zhao, Yihong; Duan, Chuanhua

    2017-08-09

    Capillary evaporation in nanoscale conduits is an efficient heat/mass transfer strategy that has been widely utilized by both nature and mankind. Despite its broad impact, the ultimate transport limits of capillary evaporation in nanoscale conduits, governed by the evaporation/condensation kinetics at the liquid-vapor interface, have remained poorly understood. Here we report experimental study of the kinetic limits of water capillary evaporation in two dimensional nanochannels using a novel hybrid channel design. Our results show that the kinetic-limited evaporation fluxes break down the limits predicated by the classical Hertz-Knudsen equation by an order of magnitude, reaching values up to 37.5 mm/s with corresponding heat fluxes up to 8500 W/cm 2 . The measured evaporation flux increases with decreasing channel height and relative humidity but decreases as the channel temperature decreases. Our findings have implications for further understanding evaporation at the nanoscale and developing capillary evaporation-based technologies for both energy- and bio-related applications.

  12. Documentation of a Conduit Flow Process (CFP) for MODFLOW-2005

    Science.gov (United States)

    Shoemaker, W. Barclay; Kuniansky, Eve L.; Birk, Steffen; Bauer, Sebastian; Swain, Eric D.

    2007-01-01

    This report documents the Conduit Flow Process (CFP) for the modular finite-difference ground-water flow model, MODFLOW-2005. The CFP has the ability to simulate turbulent ground-water flow conditions by: (1) coupling the traditional ground-water flow equation with formulations for a discrete network of cylindrical pipes (Mode 1), (2) inserting a high-conductivity flow layer that can switch between laminar and turbulent flow (Mode 2), or (3) simultaneously coupling a discrete pipe network while inserting a high-conductivity flow layer that can switch between laminar and turbulent flow (Mode 3). Conduit flow pipes (Mode 1) may represent dissolution or biological burrowing features in carbonate aquifers, voids in fractured rock, and (or) lava tubes in basaltic aquifers and can be fully or partially saturated under laminar or turbulent flow conditions. Preferential flow layers (Mode 2) may represent: (1) a porous media where turbulent flow is suspected to occur under the observed hydraulic gradients; (2) a single secondary porosity subsurface feature, such as a well-defined laterally extensive underground cave; or (3) a horizontal preferential flow layer consisting of many interconnected voids. In this second case, the input data are effective parameters, such as a very high hydraulic conductivity, representing multiple features. Data preparation is more complex for CFP Mode 1 (CFPM1) than for CFP Mode 2 (CFPM2). Specifically for CFPM1, conduit pipe locations, lengths, diameters, tortuosity, internal roughness, critical Reynolds numbers (NRe), and exchange conductances are required. CFPM1, however, solves the pipe network equations in a matrix that is independent of the porous media equation matrix, which may mitigate numerical instability associated with solution of dual flow components within the same matrix. CFPM2 requires less hydraulic information and knowledge about the specific location and hydraulic properties of conduits, and turbulent flow is approximated by

  13. Drill pipes and casings utilizing multi-conduit tubular; Flerkanals roerstreng

    Energy Technology Data Exchange (ETDEWEB)

    Curlett, H.B.

    1997-04-23

    The invention relates to a multi-conduit tubular having fluid conduits and electrical conduits, with associated surface fluid and electrical commutators, and downhole sensors for providing surface monitors with instantaneous formation data. Each tubular includes a plurality of uniform linear conduits there through, with a gasket seal plate interposed between joined tubular for assuring a high pressure seal between joined conduits. the seal plate includes an intermediate electrical connector for connecting electrical conduit connectors of one tubular to another. A coupling collar with uniform diameter internal coarse and fine threads joins the tubular ends having similar threads by differential thread action without respective tubular rotation. Each tubular end includes an inter-engaging index recess and index lug, and drive recesses and lugs for maintaining angular registry of the tubular string and for driving one drill tubular with another. A fluid commutator includes a rotating shaft with passages connected to the tubular conduits, and rotating in a manifold having annular grooves in communication with the shaft passages and external fluid sources. An adaptor couples each commutator shaft passage to one or more tubular conduits. Slip rings on a quill shaft and stationary brush means provide electrical continuity from the electrical conduit wires to surface equipment. A cross-over sub includes formation parameter sensors and telemetry equipment in a blocked off portion of a fluid conduit. An annular accumulator connected with the well bore annulus applies a pressure thereto in response to downhole sensors to change the effective density of the drill mud. The multi-conduit tubular is further adapted for use as a well casing to provide downhole access of a plurality of fluids and electrical parameter sensors. 28 figs.

  14. Silicic magma differentiation in ascent conduits. Experimental constraints

    Science.gov (United States)

    Rodríguez, Carmen; Castro, Antonio

    2017-02-01

    Crystallization of water-bearing silicic magmas in a dynamic thermal boundary layer is reproduced experimentally by using the intrinsic thermal gradient of piston-cylinder assemblies. The standard AGV2 andesite under water-undersaturated conditions is set to crystallize in a dynamic thermal gradient of about 35 °C/mm in 10 mm length capsules. In the hotter area of the capsule, the temperature is initially set at 1200 °C and decreases by programmed cooling at two distinct rates of 0.6 and 9.6 °C/h. Experiments are conducted in horizontally arranged assemblies in a piston cylinder apparatus to avoid any effect of gravity settling and compaction of crystals in long duration runs. The results are conclusive about the effect of water-rich fluids that are expelled out the crystal-rich zone (mush), where water saturation is reached by second boiling in the interstitial liquid. Expelled fluids migrate to the magma ahead of the solidification front contributing to a progressive enrichment in the fluxed components SiO2, K2O and H2O. The composition of water-rich fluids is modelled by mass balance using the chemical composition of glasses (quenched melt). The results are the basis for a model of granite magma differentiation in thermally-zoned conduits with application of in-situ crystallization equations. The intriguing textural and compositional features of the typical autoliths, accompanying granodiorite-tonalite batholiths, can be explained following the results of this study, by critical phenomena leading to splitting of an initially homogeneous magma into two magma systems with sharp boundaries. Magma splitting in thermal boundary layers, formed at the margins of ascent conduits, may operate for several km distances during magma transport from deep sources at the lower crust or upper mantle. Accordingly, conduits may work as chromatographic columns contributing to increase the silica content of ascending magmas and, at the same time, leave behind residual mushes that

  15. Characterization of molecule and particle transport through nanoscale conduits

    Science.gov (United States)

    Alibakhshi, Mohammad Amin

    Nanofluidic devices have been of great interest due to their applications in variety of fields, including energy conversion and storage, water desalination, biological and chemical separations, and lab-on-a-chip devices. Although these applications cross the boundaries of many different disciplines, they all share the demand for understanding transport in nanoscale conduits. In this thesis, different elusive aspects of molecule and particle transport through nanofluidic conduits are investigated, including liquid and ion transport in nanochannels, diffusion- and reaction-governed enzyme transport in nanofluidic channels, and finally translocation of nanobeads through nanopores. Liquid or solvent transport through nanoconfinements is an essential yet barely characterized component of any nanofluidic systems. In the first chapter, water transport through single hydrophilic nanochannels with heights down to 7 nm is experimentally investigated using a new measurement technique. This technique has been developed based on the capillary flow and a novel hybrid nanochannel design and is capable of characterizing flow in both single nanoconduits as well as nanoporous media. The presence of a 0.7 nm thick hydration layer on hydrophilic surfaces and its effect on increasing the hydraulic resistance of the nanochannels is verified. Next, ion transport in a new class of nanofluidic rectifiers is theoretically and experimentally investigated. These so called nanofluidic diodes are nanochannels with asymmetric geometries which preferentially allow ion transport in one direction. A nondimensional number as a function of electrolyte concentration, nanochannel dimensions, and surface charge is derived that summarizes the rectification behavior of this system. In the fourth chapter, diffusion- and reaction-governed enzyme transport in nanofluidic channels is studied and the theoretical background necessary for understanding enzymatic activity in nanofluidic channels is presented. A

  16. Von der Medienwirkungsbehauptung zur erziehungswissenschaftlichen Medienrezeptionsforschung. Vorschlag zur Analyse von Filmkommunikaten

    Directory of Open Access Journals (Sweden)

    Barbara Drinck

    2001-04-01

    Full Text Available Im Hinblick auf die Erforschung spezifischer Zusammenhänge von Medienkonsum und der Herausbildung von Einstellungen und Handlungen wird eine konstruktivistische Theorieorientierung plausibilisiert, indem zunächst auf den Stand der Medienwirkungsforschung eingegangen und vor dem Hintergrund einer begründeten Kritik des Wirkungsverständnisses auf die Notwendigkeit einer medienrezeptionswissenschaftlichen Forschungsalternative hingewiesen wird. Weiterhin wird der Stand der (erziehungswissenschaftlichen Medienrezeptionsforschung erörtert. Sodann werden Elemente einer konstruktivistischen Methodologie von Medienrezeptionsforschung beschrieben, die am Beispiel der Rezeption von Filmen konkretisiert werden. Dabei wird das Konzept des Kommunikates (S.J. Schmidt als Ausgangspunkt genommen, ein Vorschlag für eine Beschreibungssprache für (Film- Kommunikate entwickelt und eine Adaption des Ansatzes filmischer Narration zur Sprache gebracht.

  17. Twenty years of cable-in-conduit conductors: 1975-1995

    International Nuclear Information System (INIS)

    Dresner, L.

    1995-01-01

    This paper reviews our progress during the last two decades in understanding cable-in-conduit conductors. The emphasis is on the physical principles governing the behavior of cable-in-conduit conductors, and no detailed mathematics is presented. The paper is constructed as a historical narrative

  18. 26 CFR 1.58-2 - General rules for conduit entities; partnerships and partners.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 1 2010-04-01 2010-04-01 true General rules for conduit entities; partnerships...; partnerships and partners. (a) General rules for conduit entities. Sections 1.58-3 through 1.58-6 provide rules... example, if a trust has $100,000 of capital gains for the taxable year, all of which are distributed to A...

  19. Midterm performance of a novel restorative pulmonary valved conduit: preclinical results

    NARCIS (Netherlands)

    Soliman, Osama I.; Miyazaki, Yosuke; Abdelghani, Mohammad; Brugmans, Marieke; Witsenburg, Maarten; Onuma, Yoshinobu; Cox, Martijn; Serruys, Patrick W.

    2017-01-01

    Aims: The Xeltis bioabsorbable pulmonary valved conduit (XPV), designed to guide functional restoration of patients' own tissue, is potentially more durable than current pulmonary bioprosthetic valves/valved conduits. The aim of this study was to assess the haemodynamic performance of the novel XPV

  20. 78 FR 56872 - City of Barre, Vermont; Notice of Preliminary Determination of a Qualifying Conduit Hydropower...

    Science.gov (United States)

    2013-09-16

    ..., Vermont; Notice of Preliminary Determination of a Qualifying Conduit Hydropower Facility and Soliciting... construct a qualifying conduit hydropower facility, pursuant to section 30 of the Federal Power Act, as amended by section 4 of the Hydropower Regulatory Efficiency Act of 2013 (HREA). The Nelson Street 17 kW...

  1. 78 FR 66355 - Pleasant Grove City, UT; Notice of Preliminary Determination of a Qualifying Conduit Hydropower...

    Science.gov (United States)

    2013-11-05

    ... City, UT; Notice of Preliminary Determination of a Qualifying Conduit Hydropower Facility and... Grove City, Utah (Pleasant Grove) filed a notice of intent to construct a qualifying conduit hydropower facility, pursuant to section 30 of the Federal Power Act, as amended by section 4 of the Hydropower...

  2. 78 FR 61987 - Corbett Water District; Notice of Preliminary Determination of a Qualifying Conduit Hydropower...

    Science.gov (United States)

    2013-10-09

    ... District; Notice of Preliminary Determination of a Qualifying Conduit Hydropower Facility and Soliciting... construct a qualifying conduit hydropower facility, pursuant to section 30 of the Federal Power Act, as amended by section 4 of the Hydropower Regulatory Efficiency Act of 2013 (HREA). The Corbett Hydroelectric...

  3. 78 FR 53752 - City of Sandpoint, Idaho; Notice of Preliminary Determination of a Qualifying Conduit Hydropower...

    Science.gov (United States)

    2013-08-30

    ... Sandpoint, Idaho; Notice of Preliminary Determination of a Qualifying Conduit Hydropower Facility and... intent to construct a qualifying conduit hydropower facility, pursuant to section 30 of the Federal Power Act, as amended by section 4 of the Hydropower Regulatory Efficiency Act of 2013 (HREA). The Little...

  4. 78 FR 61985 - City of Astoria, Oregon; Notice of Preliminary Determination of a Qualifying Conduit Hydropower...

    Science.gov (United States)

    2013-10-09

    ..., Oregon; Notice of Preliminary Determination of a Qualifying Conduit Hydropower Facility and Soliciting... of intent to construct a qualifying conduit hydropower facility, pursuant to section 30 of the Federal Power Act, as amended by section 4 of the Hydropower Regulatory Efficiency Act of 2013 (HREA). The...

  5. 78 FR 63176 - Notice of Preliminary Determination of a Qualifying Conduit Hydropower Facility and Soliciting...

    Science.gov (United States)

    2013-10-23

    ... Preliminary Determination of a Qualifying Conduit Hydropower Facility and Soliciting Comments and Motions To... of intent to construct a qualifying conduit hydropower facility, pursuant to section 30 of the Federal Power Act, as amended by section 4 of the Hydropower Regulatory Efficiency Act of 2013 (HREA). The...

  6. Studying the causes for corrosive destruction of water conduits

    Energy Technology Data Exchange (ETDEWEB)

    Azamatova, F I; Kulinichev, G P; Porubov, I S

    1979-01-01

    Pipes from different oil and gas production administrations were selected for X-ray and metallographic studies of the cause of corrosive destruction. The chemical composition and mechanical properties of the pipe material are presented in tables. The phase composition of the corrosion products was studied by X-rays. The complex structure of the layer made up of the corrosion products was taken into consideration. The studies were conducted in an X-ray diffraction chamber. The obtained results are presented in a table. The metallographic studies showed that a significant corrosive damage of the materials of water conduits occurs as a result of the development of local corrosion processes, caused by the substantive heterogeneity of the structure of the metal, related to the nonuniform distribution of the pearlite because of carbon liquidation.

  7. Injunctions against mere conduit of information protected by copyright

    DEFF Research Database (Denmark)

    Sandfeld Jakobsen, Søren; Petersen, Clement Salung

    2011-01-01

    This paper includes an in-depth analysis of EU law and Scandinavian law on injunctions against internet access providers (IAPs) performing as mere conduit of information protected by copyright. In recent Scandinavian case law, courts have granted preliminary injunctions which have caused IAPs...... to either shut down specific internet connections allegedly used to infringe copyright or to block access to internet content, which allegedly infringed applicable copyright rules. This paper considers some significant legal challenges, which are emerging in the wake of this case law, and which should...... requires rules, which take into due consideration the special aspects related to enforcement of copyright on the internet through IAPs. Secondly, it is shown that the termination of internet connections and the blocking of access to internet content may not support the public policies behind copyright law...

  8. Hot upwelling conduit beneath the Atlas Mountains, Morocco

    Science.gov (United States)

    Sun, Daoyuan; Miller, Meghan S.; Holt, Adam F.; Becker, Thorsten W.

    2014-11-01

    The Atlas Mountains of Morocco display high topography, no deep crustal root, and regions of localized Cenozoic alkaline volcanism. Previous seismic imaging and geophysical studies have implied a hot mantle upwelling as the source of the volcanism and high elevation. However, the existence, shape, and physical properties of an associated mantle anomaly are debated. Here we use seismic waveform analysis from a broadband deployment and geodynamic modeling to define the physical properties and morphology of the anomaly. The imaged low-velocity structure extends to ~200 km beneath the Atlas and appears ~350 K hotter than the ambient mantle with possible partial melting. It includes a lateral conduit, which suggests that the Quaternary volcanism arises from the upper mantle. Moreover, the shape and temperature of the imaged anomaly indicate that the unusually high topography of the Atlas Mountains is due to active mantle support.

  9. Investigating the influence of conduit residues on polyurethane plates

    Directory of Open Access Journals (Sweden)

    Rachel Faverzani Magnago

    Full Text Available Abstract Converting waste into a product similar to the original one or into another useful product is to save energy, protect natural resources, and bring back to the production cycle what was discarded. In that direction, new polyurethane-based composites have been developed by incorporating 5%, 10%, 15%, and 20% PVC conduit discarded by the construction industry. The objective of this study was to investigate the interaction between the phases of waste incorporation and the effect upon the new material properties. The samples were produced by the polycondensation process. Microstructural analysis revealed a reduction in pore size across the polymer matrix. However, there were no changes in thermal insulation, water absorption, compressive strength, and burning rate tests and in the thermogravimetric analysis and differential scanning calorimetry. The results from this study showed that the replacement of raw material by waste did not affect its properties.

  10. Cable-in-conduit conductor optimization for fusion magnet applications

    International Nuclear Information System (INIS)

    Miller, J.R.; Kerns, J.A.

    1987-01-01

    Careful design of the toroidal-field (TF) and poloidal-field (PF) coils in a tokamak machine using cable-in-conduit conductors (CICC) can result in quite high overall winding-pack current densities - even with the high nuclear heat loads that may be imposed in operating a fusion reactor - and thereby help reduce the overall machine size. In our design process, we systematically examined the operational environment of a magnet, e.g., mechanical stresses, current, field, heat load, coolant temperature, and cooldown stresses, to determine the optimum amounts of copper, superconductor, helium, and sheath material for the CICC. This process is being used to design the superconducting magnet systems that comprise the Tokamak Ignition/Burn Experimental Reactor (TIBER II). 13 refs., 2 figs

  11. Siebenjährige Follow-up-Studie zur Anwendung des spannungsfreien Vaginalbandes (TVT zur Behandlung der Stressharninkontinenz

    Directory of Open Access Journals (Sweden)

    Nilsson CG

    2005-01-01

    Full Text Available Studienzweck: Evaluierung der langfristigen Heilungs- und Spätkomplikationsraten bei Stressharninkontinenz der Frau bei Behandlung mit dem spannungsfreien Vaginalband (TVT, das anhand einer minimal-invasiven Operation eingesetzt wird. Methodik: In drei Studienzentren durchgeführte prospektive Beobachtungs- und Kohortenstudie mit ursprünglich 90 Frauen, deren primäre Stressharninkontinenz einen operativen Eingriff erforderlich machte. Zu den Bewertungsvariablen gehörten ein Vorlagentest (Pad-Test zur Messung des Uringewichts je 24 Stunden, ein Stresstest, eine visuelle Analogskala (VAS zur Beurteilung des Beschwerdegrads sowie ein Fragebogen zur Beurteilung der subjektiven Wahrnehmung des Kontinenzstatus durch die Frauen. Ergebnisse: Als Follow-up-Zeitraum wurde ein durchschnittlicher Zeitraum von 91 Monaten (78–100 Monate festgelegt. Sowohl die objektive als auch die subjektive Heilungsrate lag bei den an der Follow-up-Studie teilnehmenden 80 Frauen bei 81,3 %. Bei 7,8 % der Frauen wurde ein asymptomatischer Prolaps der Organe des kleinen Beckens, bei 6,3 % De-novo-Drangsymptome und bei 7,5 % eine rezidivierende Harnwegsinfektion festgestellt. Weitere unerwünschte Nebenwirkungen des Verfahrens wurden nicht festgestellt. Schlussfolgerung: Die Wirkung der TVT-Operation zur Behandlung der Stressharninkontinenz der Frau bleibt über einen Zeitraum von 7 Jahren erhalten.

  12. Novel technique for airless connection of artificial heart to vascular conduits.

    Science.gov (United States)

    Karimov, Jamshid H; Gao, Shengqiang; Dessoffy, Raymond; Sunagawa, Gengo; Sinkewich, Martin; Grady, Patrick; Sale, Shiva; Moazami, Nader; Fukamachi, Kiyotaka

    2017-12-01

    Successful implantation of a total artificial heart relies on multiple standardized procedures, primarily the resection of the native heart, and exacting preparation of the atrial and vascular conduits for pump implant and activation. Achieving secure pump connections to inflow/outflow conduits is critical to a successful outcome. During the connection process, however, air may be introduced into the circulation, traveling to the brain and multiple organs. Such air emboli block blood flow to these areas and are detrimental to long-term survival. A correctly managed pump-to-conduit connection prevents air from collecting in the pump and conduits. To further optimize pump-connection techniques, we have developed a novel connecting sleeve that enables airless connection of the Cleveland Clinic continuous-flow total artificial heart (CFTAH) to the conduits. In this brief report, we describe the connecting sleeve design and our initial results from two acute in vivo implantations using a scaled-down version of the CFTAH.

  13. Development and Implementation of a Segment/Junction Box Level Database for the ITS Fiber Optic Conduit Network

    Science.gov (United States)

    2012-03-01

    This project initiated the development of a computerized database of ITS facilities, including conduits, junction : boxes, cameras, connections, etc. The current system consists of a database of conduit sections of various lengths. : Over the length ...

  14. Engineering a multimodal nerve conduit for repair of injured peripheral nerve

    Science.gov (United States)

    Quigley, A. F.; Bulluss, K. J.; Kyratzis, I. L. B.; Gilmore, K.; Mysore, T.; Schirmer, K. S. U.; Kennedy, E. L.; O'Shea, M.; Truong, Y. B.; Edwards, S. L.; Peeters, G.; Herwig, P.; Razal, J. M.; Campbell, T. E.; Lowes, K. N.; Higgins, M. J.; Moulton, S. E.; Murphy, M. A.; Cook, M. J.; Clark, G. M.; Wallace, G. G.; Kapsa, R. M. I.

    2013-02-01

    Injury to nerve tissue in the peripheral nervous system (PNS) results in long-term impairment of limb function, dysaesthesia and pain, often with associated psychological effects. Whilst minor injuries can be left to regenerate without intervention and short gaps up to 2 cm can be sutured, larger or more severe injuries commonly require autogenous nerve grafts harvested from elsewhere in the body (usually sensory nerves). Functional recovery is often suboptimal and associated with loss of sensation from the tissue innervated by the harvested nerve. The challenges that persist with nerve repair have resulted in development of nerve guides or conduits from non-neural biological tissues and various polymers to improve the prognosis for the repair of damaged nerves in the PNS. This study describes the design and fabrication of a multimodal controlled pore size nerve regeneration conduit using polylactic acid (PLA) and (PLA):poly(lactic-co-glycolic) acid (PLGA) fibers within a neurotrophin-enriched alginate hydrogel. The nerve repair conduit design consists of two types of PLGA fibers selected specifically for promotion of axonal outgrowth and Schwann cell growth (75:25 for axons; 85:15 for Schwann cells). These aligned fibers are contained within the lumen of a knitted PLA sheath coated with electrospun PLA nanofibers to control pore size. The PLGA guidance fibers within the nerve repair conduit lumen are supported within an alginate hydrogel impregnated with neurotrophic factors (NT-3 or BDNF with LIF, SMDF and MGF-1) to provide neuroprotection, stimulation of axonal growth and Schwann cell migration. The conduit was used to promote repair of transected sciatic nerve in rats over a period of 4 weeks. Over this period, it was observed that over-grooming and self-mutilation (autotomy) of the limb implanted with the conduit was significantly reduced in rats implanted with the full-configuration conduit compared to rats implanted with conduits containing only an alginate

  15. Degradation properties of the electrostatic assembly PDLLA/CS/CHS nerve conduit

    Energy Technology Data Exchange (ETDEWEB)

    Xu Haixing [School of Chemical Engineering, Wuhan University of Technology, Wuhan 430070 (China); Yan Yuhua; Wan Tao; Li Shipu, E-mail: yanyuhua8@126.co [Biomedical Materials and Engineering Research Center, Wuhan University of Technology, Wuhan 430070 (China)

    2009-08-15

    A poly(d,l-lactic acid)/chondroitin sulfate/chitosan (PDLLA/CS/CHS) nerve conduit for repairing nerve defects was prepared by electrostatic assembly and the thermally induced phase separation technique. The hydrophilic characteristics of the PDLLA/CS/CHS assembly nerve conduits were improved markedly. The degradation behavior of the nerve conduit with various assembly layers was evaluated by a pH change, weight loss rate and molecular weight change. The pH of the solution of the nerve conduit could be effectively adjusted by varying the layer numbers and overcoming the acidity-caused auto-acceleration of PDLLA; the nerve conduit can retain its integrity in a phosphate buffer solution after being degraded for 3 months. After such a conduit was implanted in the rat for 3 months, obvious degradation occurred, but the regenerated nerve was integrated and it grew successfully from the proximal to distal nerve stump. All these results implied that the degradation rate of the prepared conduit can adapt to the regeneration of the peripheral nerve, which might be a new derivative of PDLLA-based biodegradable materials for repairing nerve injuries without acidity-caused irritations and acidity-induced auto-accelerating degradation behavior as shown by PDLLA.

  16. Hydrothermal Alteration of the Mt Unzen Conduit (Shimabara/Japan)

    Science.gov (United States)

    Yilmaz, T. I.; Mayer, K.; Hess, K. U.; Janots, E.; Gilg, H. A.; Dingwell, D. B.

    2016-12-01

    Investigations were carried out on hydrothermally altered coherent dacitic dykes samples from (USDP-4) drill core at Mt Unzen stratovolcano (Shimabara/Japan). XRF, XRD, EMPA, and C-O-isotope analysis led to insights concerning chemistry, mineralogy, and intensity of alteration as well as the origin of carbonate-precipitating fluids. Additionally a textural characterization of the occurring replacement features in the magma conduit zone was performed. The occurrence of the main secondary phases such as chlorite, pyrite, carbonates, and R1 (Reichweite parameter) illite-smectite indicate a weak to moderate propylitic to phyllic hydrothermal alteration. The dacitic samples of the dykes show different hydrothermal alteration features: (i) carbonate pseudomorphs after hornblende as well as core and zonal textures due to replacement of plagioclase by R1 illite-smectite, (ii) colloform banded fracture fillings and fillings in dissolution vugs, and (iii) chlorite and R1 illite-smectite in the groundmass. Carbonates in fractures comprise iron-rich dolomite solid solutions ("ankerite") and calcite. Isotopic values of d13Cvpdb = -4.59 ± 0.6‰ and d18Ovpdb = -21.73 ± 0.5‰ indicate a hydrothermal-magmatic origin for the carbonate formation. The chlorite-carbonate-pyrite index (CCPI) and the Ishikawa alteration index (AI), applied to the investigated samples show significant differences (CCPI=52.7-57.8; AI=36.1-40.6) indicating their different degree of alteration. According to Nakada et al., 2005, the C13 to C16 dykes represent the feeder dyke from the latest eruption (1991-1995) whereas C8 represents an earlier dyke feeder dyke from an older eruption. Weakest conduit alteration, which was obtained in samples C16-1-5 and C13-2-5, correlates with the alteration degree of the pristine dome rocks. Highest CCPI value was determined for sample C14-1-5 and the highest AI value was determined for sample C15-2-6. The degrees of alteration do not indicate highest alteration of the

  17. Entwicklung eines kontinuierlichen Verfahrens zur enzymkatalysierten Synthese eines strukturierten Triglycerides

    OpenAIRE

    Stadler, Hans-Gerhard

    2005-01-01

    Ausgangspunkt für die in der vorliegenden Arbeit durchgeführten Entwicklung eines kontinuierlichen Verfahrens zur Synthese des strukturierten Triglycerides 1,3-Oleyl-2-palmitoylglycerin war die von Schmid [Schmid 1999] entwickelte lipase-katalysierte Zwei-Schritt-Synthese für strukturierte Triglyceride vom Typ ABA [European Patent Application; EP 0 882 797 A2]. In der ersten Reaktionsstufe dieser zweistufigen Umesterung wird in einer Folgereaktion das Substrat Tripalmitin mit Hilfe ein...

  18. Offenheit: Poster zur Nacht des Wissens Hamburg 2015

    OpenAIRE

    Hapke, Thomas; Rajski, Beate; Bieler, Detlev

    2015-01-01

    Die Posterserie zum Thema Offenheit wurde von der Universitätsbibliothek der Technischen Universität Hamburg für die Nacht des Wissens am 7. November 2015 erstellt. Sie enthält die Poster Offenheit vonWissen Open Access Open Access Publizieren Offene Inhalte - Creative Commons Lizenzen TUBdok: Open Access Repository der TUHH Offene Bildung - Open Educational Resources Zur Geschichte der Offenheit des Wissens

  19. Strategien zur HLA-Typisierung mit PyrosequencingTM

    OpenAIRE

    Entz, Patricia

    2006-01-01

    Der Haupthistokompatibilitätskomplex ist durch seine biologische Funktion eine für die Diagnostik und Forschung äußerst wichtige Region im humanen Genom. Die Untersuchung von HLA-Genorten stellt ein wichtiges Instrument in der molekulargenetischen Praxis dar. Die Pyrosequencing-Technik ist gut geeignet, um kurze DNA-Abschnitte mit weitgehend bekannter Sequenz schnell und effizient zu untersuchen. Ziel dieser Arbeit war die Entwicklung von Pyrosequencing-basierten Methoden zur HLA-Typisierung....

  20. Zur Dialektik von Soft Skills und fachlicher Kompetenz

    OpenAIRE

    Jendrowiak, Hans-Werner

    2010-01-01

    [Der Autor stellt folgende Thesen zur Dialektik von Soft Skills und fachlicher Bildung auf:] 1. Soft Skills sind normale Bildungskategorien und Teil einer Allgemeinen Bildung. […] 2. Soft Skills sind als personalgebundene Kriterien auch immer schon Gegenstand bildungstheoretischer Debatten. […] 3. Soft Skills ist eine trendorientierte Bezeichnung für Bildung. […] 4. Soft Skills sind Ausdruck von Vorstellungen, Ideen und Theorien (Schulkultur, Unternehmenskultur, Unternehmensphilosophie). 5. S...

  1. Ein Beitrag zur Erweiterung von Beamforming-Methoden

    OpenAIRE

    Kern, Marcus

    2008-01-01

    Im automobilen Entwicklungsprozess haben sich akustische Messsysteme etabliert, die mit einer Anordnung von Mikrofonen, einer optischen Kamera und einer nachgeschalteten Signalverarbeitung die Schalleinfallsrichtung detektieren und dadurch die Schalldruckverteilung auf Quellorte im Fernfeld zurückrechnen und visualisieren können. Die Signalverarbeitung beruht i. A. auf dem Delay&Sum-Beamforming, deren Umsetzung im Zeit- oder Frequenzbereich erfolgt. Die Schwächen dieser Messtechnik bezüglich ...

  2. Conduits to care: call lights and patients’ perceptions of communication

    Science.gov (United States)

    Montie, Mary; Shuman, Clayton; Galinato, Jose; Patak, Lance; Anderson, Christine A; Titler, Marita G

    2017-01-01

    Background Call light systems remain the primary means of hospitalized patients to initiate communication with their health care providers. Although there is vast amounts of literature discussing patient communication with their health care providers, few studies have explored patients’ perceptions concerning call light use and communication. The specific aim of this study was to solicit patients’ perceptions regarding their call light use and communication with nursing staff. Methods Patients invited to this study met the following inclusion criteria: proficient in English, been hospitalized for at least 24 hours, aged ≥21 years, and able to communicate verbally (eg, not intubated). Thirty participants provided written informed consent, were enrolled in the study, and completed interviews. Results Using qualitative descriptive methods, five major themes emerged from patients’ perceptions (namely; establishing connectivity, participant safety concerns, no separation: health care and the call light device, issues with the current call light, and participants’ perceptions of “nurse work”). Multiple minor themes supported these major themes. Data analysis utilized the constant comparative methods of Glaser and Strauss. Discussion Findings from this study extend the knowledge of patients’ understanding of not only why inconsistencies occur between the call light and their nurses, but also why the call light is more than merely a device to initiate communication; rather, it is a direct conduit to their health care and its delivery. PMID:29075125

  3. Conduits to care: call lights and patients' perceptions of communication.

    Science.gov (United States)

    Montie, Mary; Shuman, Clayton; Galinato, Jose; Patak, Lance; Anderson, Christine A; Titler, Marita G

    2017-01-01

    Call light systems remain the primary means of hospitalized patients to initiate communication with their health care providers. Although there is vast amounts of literature discussing patient communication with their health care providers, few studies have explored patients' perceptions concerning call light use and communication. The specific aim of this study was to solicit patients' perceptions regarding their call light use and communication with nursing staff. Patients invited to this study met the following inclusion criteria: proficient in English, been hospitalized for at least 24 hours, aged ≥21 years, and able to communicate verbally (eg, not intubated). Thirty participants provided written informed consent, were enrolled in the study, and completed interviews. Using qualitative descriptive methods, five major themes emerged from patients' perceptions (namely; establishing connectivity, participant safety concerns, no separation: health care and the call light device, issues with the current call light, and participants' perceptions of "nurse work"). Multiple minor themes supported these major themes. Data analysis utilized the constant comparative methods of Glaser and Strauss. Findings from this study extend the knowledge of patients' understanding of not only why inconsistencies occur between the call light and their nurses, but also why the call light is more than merely a device to initiate communication; rather, it is a direct conduit to their health care and its delivery.

  4. Relaxation of microparticles exposed to hydrodynamic forces in microfluidic conduits.

    Science.gov (United States)

    Janča, Josef; Halabalová, Věra; Polášek, Vladimír; Vašina, Martin; Menshikova, Anastasia Yu

    2011-02-01

    The behavior of microparticles exposed to gravitational and lift forces and to the velocity gradient in flow velocity profile formed in microfluidic conduits is studied from the viewpoint of the transient period (the relaxation) between the moment at which a particle starts to be transported by the hydrodynamic flow and the time at which it reaches an equilibrium position, characterized by a balance of all active forces. The theoretical model allowing the calculation of the relaxation time is proposed. The numerical calculus based on the proposed model is compared with the experimental data obtained under different experimental conditions, namely, for different lengths of microfluidic channels, different average linear velocities of the carrier liquid, and different sizes and densities of the particles used in the study. The results are important for the optimization of microfluidic separation units such as microthermal field-flow fractionation channels in which the separation or manipulation of the microparticles of various origin, synthetic, natural, biological, etc., is performed under similar experimental conditions but by applying an additional thermodynamic force.

  5. Alexandru Popa, Untersuchungen zu den römisch-barbarischen Kontakten Östlich der römischen Provinz Dacia Antiquitatis reihe 3 Abhnadlungen zur vor-und frühgeschichte, zur klassichen und provinzial-römischen archäologie und zur geschichte des altertum

    Directory of Open Access Journals (Sweden)

    Vasile Iarmulschi

    2016-06-01

    Full Text Available Review on book - Alexandru Popa, Untersuchungen zu den römisch-barbarischen Kontakten Östlich der römischen Provinz Dacia Antiquitatis reihe 3 Abhnadlungen zur vor-und frühgeschichte, zur klassichen und provinzial-römischen archäologie und zur geschichte des altertum

  6. Scientific Results of Conduit Drilling in the Unzen Scientific Drilling Project (USDP

    Directory of Open Access Journals (Sweden)

    Kozo Uto

    2005-09-01

    Full Text Available Abstract Directional drilling at Unzen Volcano in Japan duringmid of 2004 penetrated the magma conduit and successfullyrecovered samples of the lava dike that is believed to havefed the 1991–1995 eruption. The dike was sampled about1.3 km below the volcano’s summit vent and is intrudedinto a broader conduit zone that is 0.5 km wide. This zoneconsists of multiple older lava dikes and pyroclastic veinsand has cooled to less than 200˚C. The lava dike sample wasunexpectedly altered, suggesting that circulation of hydrothermalfluids rapidly cools the conduit region of even veryactive volcanoes. It is likely that seismic signals monitoredprior to emergence of the lava dome reflected fracturing ofthe country rocks, caused by veining as volatiles escapedpredominantly upward, not outward, from the rising magma.Geophysical and geological investigation of cuttings andcore samples from the conduit and of bore-hole logging datacontinues.

  7. Transcatheter Pulmonary Valve Replacement for Right Ventricular Outflow Tract Conduit Dysfunction After the Ross Procedure

    DEFF Research Database (Denmark)

    Gillespie, Matthew J; McElhinney, Doff B; Kreutzer, Jacqueline

    2015-01-01

    BACKGROUND: Right ventricular outflow tract (RVOT) conduit dysfunction is a limitation of the Ross procedure. Transcatheter pulmonary valve replacement (TPVR) could alter the impact of conduit dysfunction and the risk-benefit balance for the Ross procedure. METHODS: Retrospective review of databa......BACKGROUND: Right ventricular outflow tract (RVOT) conduit dysfunction is a limitation of the Ross procedure. Transcatheter pulmonary valve replacement (TPVR) could alter the impact of conduit dysfunction and the risk-benefit balance for the Ross procedure. METHODS: Retrospective review....... Of these, 56 (84%) received a Melody valve; in 5 of the 11 patients who did not, the implant was aborted due to concern for coronary artery compression, and 1 implanted patient required emergent surgery for left coronary compression. The RVOT gradient decreased from a median 38 mm Hg to 13.5 mm Hg (p

  8. Investigation of entrance length in circular and noncircular conduits by computational fluid dynamics simulation

    Directory of Open Access Journals (Sweden)

    Pimpun Tongpun

    2014-08-01

    Full Text Available This study estimated entrance length of circular and noncircular conduits, including circle, triangle, square and hexagon cross-sectional conduit, by using computational fluid dynamics (CFD. For simulation condition, the length of noncircular conduit was 10 m and the hydraulic diameter was 0.2 m. The laminar flow with Reynolds number of 500 and turbulent flow with Reynolds number of 50,000 were applied to investigate water flow in conduits. The governing equations were solved iteratively by using ANSYS FLUENT 14.0. For turbulent flow simulation, standard k-epsilon and RNG k-epsilon model were employed to simulate turbulence. The preliminary results were validated by comparison with theoretical data. At first, grid independency was evaluated to optimize the model. Norm* was employed to investigate the entrance length, which is related to velocity. The simulated results revealed that the entrance length for laminar flow was longer than turbulent flow.

  9. In vivo visualization of microneedle conduits in human skin using laser scanning microscopy

    International Nuclear Information System (INIS)

    Bal, S; Kruithof, A C; Bouwstra, J; Liebl, H; Tomerius, M; Lademann, J; Meinke, M

    2010-01-01

    Solid microneedles enhance the penetration of drugs into the viable skin but little is known about the geometry of the conduits in vivo. Therefore, laser scanning microscopy was used to visualize the conduits of a microneedle system with needles at a length of 300 μm in 6 healthy subjects over a period of time. The model drug, a fluorescent dye was applied before and after piercing. Laser scanning microscopy was evaluated as being an excellent method to monitor the geometry and closure of the conduits over time. The used microneedle system was evaluated as suitable to enhance the transport of model drugs into the viable epidermis without bleeding and a short closure time of the conduits at the skin surface

  10. In vivo visualization of microneedle conduits in human skin using laser scanning microscopy

    Science.gov (United States)

    Bal, S.; Kruithof, A. C.; Liebl, H.; Tomerius, M.; Bouwstra, J.; Lademann, J.; Meinke, M.

    2010-03-01

    Solid microneedles enhance the penetration of drugs into the viable skin but little is known about the geometry of the conduits in vivo. Therefore, laser scanning microscopy was used to visualize the conduits of a microneedle system with needles at a length of 300 μm in 6 healthy subjects over a period of time. The model drug, a fluorescent dye was applied before and after piercing. Laser scanning microscopy was evaluated as being an excellent method to monitor the geometry and closure of the conduits over time. The used microneedle system was evaluated as suitable to enhance the transport of model drugs into the viable epidermis without bleeding and a short closure time of the conduits at the skin surface.

  11. Silk fibroin enhances peripheral nerve regeneration by improving vascularization within nerve conduits.

    Science.gov (United States)

    Wang, Chunyang; Jia, Yachao; Yang, Weichao; Zhang, Cheng; Zhang, Kuihua; Chai, Yimin

    2018-07-01

    Silk fibroin (SF)-based nerve conduits have been widely used to bridge peripheral nerve defects. Our previous study showed that nerve regeneration in a SF-blended poly (l-lactide-co-ɛ-caprolactone) [P(LLA-CL)] nerve conduit is better than that in a P(LLA-CL) conduit. However, the involved mechanisms remain unclarified. Because angiogenesis within a nerve conduit plays an important role in nerve regeneration, vascularization of SF/P(LLA-CL) and P(LLA-CL) conduits was compared both in vitro and in vivo. In the present study, we observed that SF/P(LLA-CL) nanofibers significantly promoted fibroblast proliferation, and vascular endothelial growth factor secreted by fibroblasts seeded in SF/P(LLA-CL) nanofibers was more than seven-fold higher than that in P(LLA-CL) nanofibers. Conditioned medium of fibroblasts in the SF/P(LLA-CL) group stimulated more human umbilical vein endothelial cells (HUVEC) to form capillary-like networks and promoted faster HUVEC migration. The two kinds of nerve conduits were used to bridge 10-mm-length nerve defects in rats. At 3 weeks of reparation, the blood vessel area in the SF/P(LLA-CL) group was significantly larger than that in the P(LLA-CL) group. More regenerated axons and Schwann cells were also observed in the SF/P(LLA-CL) group, which was consistent with the results of blood vessels. Collectively, our data revealed that the SF/P(LLA-CL) nerve conduit enhances peripheral nerve regeneration by improving angiogenesis within the conduit. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2070-2077, 2018. © 2018 Wiley Periodicals, Inc.

  12. Ureteric catheterization via an ileal conduit: technique and retrieval of a JJ stent.

    Science.gov (United States)

    Wah, T M; Kellett, M J

    2004-11-01

    Retrograde ureteric catheterization of a patient with an ileal conduit is difficult, because guide wires and catheters coil in the conduit. A modified loopogram, using a Foley catheter as a fulcrum through which catheters can be advanced to the ureteric anastomosis, is described. This technique was used to remove a JJ stent, which had been inserted previously across a stricture in one ureter, the stent crossing from one kidney to the other.

  13. Long distance seawater intrusion through a karst conduit network in the Woodville Karst Plain, Florida

    OpenAIRE

    Zexuan Xu; Seth Willis Bassett; Bill Hu; Scott Barrett Dyer

    2016-01-01

    Five periods of increased electrical conductivity have been found in the karst conduits supplying one of the largest first magnitude springs in Florida with water. Numerous well-developed conduit networks are distributed in the Woodville Karst Plain (WKP), Florida and connected to the Gulf of Mexico. A composite analysis of precipitation and electrical conductivity data provides strong evidence that the increases in conductivity are directly tied to seawater intrusion moving inland and travel...

  14. Generation of Complex Karstic Conduit Networks with a Hydro-chemical Model

    Science.gov (United States)

    De Rooij, R.; Graham, W. D.

    2016-12-01

    The discrete-continuum approach is very well suited to simulate flow and solute transport within karst aquifers. Using this approach, discrete one-dimensional conduits are embedded within a three-dimensional continuum representative of the porous limestone matrix. Typically, however, little is known about the geometry of the karstic conduit network. As such the discrete-continuum approach is rarely used for practical applications. It may be argued, however, that the uncertainty associated with the geometry of the network could be handled by modeling an ensemble of possible karst conduit networks within a stochastic framework. We propose to generate stochastically realistic karst conduit networks by simulating the widening of conduits as caused by the dissolution of limestone over geological relevant timescales. We illustrate that advanced numerical techniques permit to solve the non-linear and coupled hydro-chemical processes efficiently, such that relatively large and complex networks can be generated in acceptable time frames. Instead of specifying flow boundary conditions on conduit cells to recharge the network as is typically done in classical speleogenesis models, we specify an effective rainfall rate over the land surface and let model physics determine the amount of water entering the network. This is advantageous since the amount of water entering the network is extremely difficult to reconstruct, whereas the effective rainfall rate may be quantified using paleoclimatic data. Furthermore, we show that poorly known flow conditions may be constrained by requiring a realistic flow field. Using our speleogenesis model we have investigated factors that influence the geometry of simulated conduit networks. We illustrate that our model generates typical branchwork, network and anastomotic conduit systems. Flow, solute transport and water ages in karst aquifers are simulated using a few illustrative networks.

  15. MR and CT imaging of pulmonary valved conduits in children and adolescents: normal appearance and complications

    Energy Technology Data Exchange (ETDEWEB)

    Tenisch, Estelle V.; Alamo, Leonor T.; Gudinchet, Francois [Lausanne University Hospital, Department of Medical Imaging, Lausanne (Switzerland); Sekarski, Nicole [Lausanne University Hospital, Department of Pediatrics, Lausanne (Switzerland); Hurni, Michel [Lausanne University Hospital, Department of Cardiovascular Surgery, Lausanne (Switzerland)

    2014-12-15

    The Contegra registered is a conduit made from the bovine jugular vein and then interposed between the right ventricle and the pulmonary artery. It is used for cardiac malformations in the reconstruction of right ventricular outflow tract. To describe both normal and pathological appearances of the Contegra registered in radiological imaging, to describe imaging of complications and to define the role of CT and MRI in postoperative follow-up. Forty-three examinations of 24 patients (17 boys and 7 girls; mean age: 10.8 years old) with Contegra registered conduits were reviewed. Anatomical description and measurements of the conduits were performed. Pathological items examined included stenosis, dilatation, plicature or twist, thrombus or vegetations, calcifications and valvular regurgitation. Findings were correlated to the echographic gradient through the conduit when available. CT and MR work-up showed Contegra registered stenosis (n = 12), dilatation (n = 9) and plicature or twist (n = 7). CT displayed thrombus or vegetations in the Contegra registered in three clinically infected patients. Calcifications of the conduit were present at CT in 12 patients and valvular regurgitation in three patients. The comparison between CT and/or MR results showed a good correlation between the echographic gradient and the presence of stenosis in the Contegra registered. CT and MR bring additional information about permeability and postoperative anatomy especially when echocardiography is inconclusive. Both techniques depict the normal appearance of the conduit, and allow comparison and precise evaluation of changes in the postoperative follow-up. (orig.)

  16. In vitro evaluation of carbon-nanotube-reinforced bioprintable vascular conduits

    International Nuclear Information System (INIS)

    Dolati, Farzaneh; Yu, Yin; Zhang, Yahui; Ozbolat, Ibrahim T; Jesus, Aribet M De; Sander, Edward A

    2014-01-01

    Vascularization of thick engineered tissue and organ constructs like the heart, liver, pancreas or kidney remains a major challenge in tissue engineering. Vascularization is needed to supply oxygen and nutrients and remove waste in living tissues and organs through a network that should possess high perfusion ability and significant mechanical strength and elasticity. In this paper, we introduce a fabrication process to print vascular conduits directly, where conduits were reinforced with carbon nanotubes (CNTs) to enhance their mechanical properties and bioprintability. In vitro evaluation of printed conduits encapsulated in human coronary artery smooth muscle cells was performed to characterize the effects of CNT reinforcement on the mechanical, perfusion and biological performance of the conduits. Perfusion and permeability, cell viability, extracellular matrix formation and tissue histology were assessed and discussed, and it was concluded that CNT-reinforced vascular conduits provided a foundation for mechanically appealing constructs where CNTs could be replaced with natural protein nanofibers for further integration of these conduits in large-scale tissue fabrication. (paper)

  17. A biosynthetic nerve guide conduit based on silk/SWNT/fibronectin nanocomposite for peripheral nerve regeneration.

    Directory of Open Access Journals (Sweden)

    Fatemeh Mottaghitalab

    Full Text Available As a contribution to the functionality of nerve guide conduits (NGCs in nerve tissue engineering, here we report a conduit processing technique through introduction and evaluation of topographical, physical and chemical cues. Porous structure of NGCs based on freeze-dried silk/single walled carbon nanotubes (SF/SWNTs has shown a uniform chemical and physical structure with suitable electrical conductivity. Moreover, fibronectin (FN containing nanofibers within the structure of SF/SWNT conduits produced through electrospinning process have shown aligned fashion with appropriate porosity and diameter. Moreover, fibronectin remained its bioactivity and influenced the adhesion and growth of U373 cell lines. The conduits were then implanted to 10 mm left sciatic nerve defects in rats. The histological assessment has shown that nerve regeneration has taken places in proximal region of implanted nerve after 5 weeks following surgery. Furthermore, nerve conduction velocities (NCV and more myelinated axons were observed in SF/SWNT and SF/SWNT/FN groups after 5 weeks post implantation, indicating a functional recovery for the injured nerves. With immunohistochemistry, the higher S-100 expression of Schwann cells in SF/SWNT/FN conduits in comparison to other groups was confirmed. In conclusion, an oriented conduit of biocompatible SF/SWNT/FN has been fabricated with acceptable structure that is particularly applicable in nerve grafts.

  18. The Himalayas: barrier and conduit for gene flow.

    Science.gov (United States)

    Gayden, Tenzin; Perez, Annabel; Persad, Patrice J; Bukhari, Areej; Chennakrishnaiah, Shilpa; Simms, Tanya; Maloney, Trisha; Rodriguez, Kristina; Herrera, Rene J

    2013-06-01

    The Himalayan mountain range is strategically located at the crossroads of the major cultural centers in Asia, the Middle East and Europe. Although previous Y-chromosome studies indicate that the Himalayas served as a natural barrier for gene flow from the south to the Tibetan plateau, this region is believed to have played an important role as a corridor for human migrations between East and West Eurasia along the ancient Silk Road. To evaluate the effects of the Himalayan mountain range in shaping the maternal lineages of populations residing on either side of the cordillera, we analyzed mitochondrial DNA variation in 344 samples from three Nepalese collections (Newar, Kathmandu and Tamang) and a general population of Tibet. Our results revealed a predominantly East Asian-specific component in Tibet and Tamang, whereas Newar and Kathmandu are both characterized by a combination of East and South Central Asian lineages. Interestingly, Newar and Kathmandu harbor several deep-rooted Indian lineages, including M2, R5, and U2, whose coalescent times from this study (U2, >40 kya) and previous reports (M2 and R5, >50 kya) suggest that Nepal was inhabited during the initial peopling of South Central Asia. Comparisons with our previous Y-chromosome data indicate sex-biased migrations in Tamang and a founder effect and/or genetic drift in Tamang and Newar. Altogether, our results confirm that while the Himalayas acted as a geographic barrier for human movement from the Indian subcontinent to the Tibetan highland, it also served as a conduit for gene flow between Central and East Asia. Copyright © 2013 Wiley Periodicals, Inc.

  19. Current distribution in Cable-In-Conduit Conductors

    International Nuclear Information System (INIS)

    Ferri, M.A.

    1994-05-01

    A numerical study of the current distribution in Cable-In-Conduit Conductors (CICC's) experiencing linearly ramping transport currents and transverse magnetic fields was conducted for both infinitely long, periodic cables and finite length cables terminated in low resistance joints. The goal of the study was to gain insight into the phenomenon known as Ramp Rate Limitation, an as yet unexplained correspondence between maximum attainable current and the ramp time taken to reach that current in CICC superconducting magnets. A discrete geometric model of a 27 strand multiply twisted CICC was developed to effectively represent the flux linkages, mutual inductances, and resistive contact points between the strands of an experimentally tested cable. The results of the numerical study showed that for fully periodic cables, the current imbalances due to ramping magnetic fields and ramping transport currents are negligible in the range of experimentally explored operating conditions. For finite length, joint terminated cables, however, significant imbalances can exist. Unfortunately, quantitative results are limited by a lack of knowledge of the transverse resistance between strands in the joints. Nonetheless, general results are presented showing the dependency of the imbalance on cable length, ramp time, and joint resistance for both ramping transverse magnet fields and ramping transport currents. At the conclusion of the study, it is suggested that calculated current imbalances in a finite length cable could cause certain strands to prematurely ''quench'' -- become non-superconducting --thus leading to an instability for the entire cable. This numerically predicted ''current imbalance instability'' is compared to the experimentally observed Ramp Rate Limitation for the 27 strand CICC sample

  20. Conduits to care: call lights and patients’ perceptions of communication

    Directory of Open Access Journals (Sweden)

    Montie M

    2017-09-01

    Full Text Available Mary Montie,1 Clayton Shuman,1 Jose Galinato,1 Lance Patak,2 Christine A Anderson,1 Marita G Titler1 1Department of Systems, Populations, and Leadership, School of Nursing, University of Michigan, Ann Arbor, MI, 2Department of Anesthesiology and Pain Medicine, Seattle Children’s Hospital, Seattle, WA, USA Background: Call light systems remain the primary means of hospitalized patients to initiate communication with their health care providers. Although there is vast amounts of literature discussing patient communication with their health care providers, few studies have explored patients’ perceptions concerning call light use and communication. The specific aim of this study was to solicit patients’ perceptions regarding their call light use and communication with nursing staff. Methods: Patients invited to this study met the following inclusion criteria: proficient in English, been hospitalized for at least 24 hours, aged ≥21 years, and able to communicate verbally (eg, not intubated. Thirty participants provided written informed consent, were enrolled in the study, and completed interviews. Results: Using qualitative descriptive methods, five major themes emerged from patients’ perceptions (namely; establishing connectivity, participant safety concerns, no separation: health care and the call light device, issues with the current call light, and participants’ perceptions of “nurse work”. Multiple minor themes supported these major themes. Data analysis utilized the constant comparative methods of Glaser and Strauss. Discussion: Findings from this study extend the knowledge of patients’ understanding of not only why inconsistencies occur between the call light and their nurses, but also why the call light is more than merely a device to initiate communication; rather, it is a direct conduit to their health care and its delivery. Keywords: nurse–patient communication, medical technology, quality of care, qualitative research

  1. A polymer foam conduit seeded with Schwann cells promotes guided peripheral nerve regeneration.

    Science.gov (United States)

    Hadlock, T; Sundback, C; Hunter, D; Cheney, M; Vacanti, J P

    2000-04-01

    Alternatives to autografts have long been sought for use in bridging neural gaps. Many entubulation materials have been studied, although with generally disappointing results in comparison with autografts. The purpose of this study was to design a more effective neural guidance conduit, to introduce Schwann cells into the conduit, and to determine regenerative capability through it in an in vivo model. A novel, fully biodegradable polymer conduit was designed and fabricated for use in peripheral nerve repair, which approximates the macro- and microarchitecture of native peripheral nerves. It comprised a series of longitudinally aligned channels, with diameters ranging from 60 to 550 microns. The lumenal surfaces promoted the adherence of Schwann cells, whose presence is known to play a key role in nerve regeneration. This unique channel architecture increased the surface area available for Schwann cell adherence up to five-fold over that available through a simple hollow conduit. The conduit was composed of a high-molecular-weight copolymer of lactic and glycolic acids (PLGA) (MW 130,000) in an 85:15 monomer ratio. A novel foam-processing technique, employing low-pressure injection molding, was used to create highly porous conduits (approximately 90% pore volume) with continuous longitudinal channels. Using this technique, conduits were constructed containing 1, 5, 16, 45, or more longitudinally aligned channels. Prior to cellular seeding of these conduits, the foams were prewet with 50% ethanol, flushed with physiologic saline, and coated with laminin solution (10 microg/mL). A Schwann cell suspension was dynamically introduced into these processed foams at a concentration of 5 X 10(5) cells/mL, using a simple bioreactor flow loop. In vivo regeneration studies were carried out in which cell-laden five-channel polymer conduits (individual channel ID 500 microm, total conduit OD 2.3 mm) were implanted across a 7-mm gap in the rat sciatic nerve (n = 4), and midgraft

  2. Fabrication and Optimization of Gelatin/ Nano Bioglass Conduits for Peripheral Nerve Regeneration

    Directory of Open Access Journals (Sweden)

    M. Foroutan Koudehi

    2014-07-01

    Full Text Available Introduction & Objective: Peripheral nerve injury is common in trauma patients and 4.5% of all soft-tissue injuries are accompanied by defects of peripheral nerve. Peripheral nerve injuries can lead to lifetime loss of function and permanent disfigurement. Designed conduits com-prised of natural and synthetic materials are now widely used in the construction of damaged tissues. The aim of this project was to prepare nanocomposite conduits from gelatin and bioglass for damaged peripheral nerve reconstruction. Materials & Methods: In this experimental study,compound water solution of gelatin and nano bioglass synthesized through sol gel method, was made. After preparing the solution, special mandrels were dipped in solution several times and freeze dried in order to be emptied of wa-ter via sublimation. The conduits had the following dimensions: internal diameter: 1.6 mm, outside diameter: 2.2 mm and length about 12 mm. In order to evaluate the biocompatibility of conduits we used cytotoxicity test by Chinese ovary cells and MTT assay by Miapaca-2 (pancreatic cancer cell line. Results: The prepared nano bioglass and conduits were characterized using transmission elec-tron microscopy, scanning electron microscopy, fourier transformed infrared spectroscopy and X-ray diffraction. Results of biocompatibility test showed no sign of cytotoxicity and cells were found to be attached to the pore walls offered by the conduits. Conclusion: According to the results, nano bioglass conduits could be a good candidate for peripheral nerve regeneration. (Sci J Hamadan Univ Med Sci 2014; 21 (2:152-160

  3. Polymeric Nerve Conduits with Contact Guidance Cues Used in Nerve Repair

    Institute of Scientific and Technical Information of China (English)

    G DAI; X NIU; J YIN

    2016-01-01

    In the modern life, the nerve injury frequently happens due to mechanical, chemical or thermal accidents. In the trivial injuries, the peripheral nerves can regenerate on their own; however, in most of the cases the clinical treatments are required, where relatively large nerve injury gaps are formed. Currently, the nerve repair can be accomplished by direct suture when the injury gap is not too large;while the autologous nerve graft working as the gold standard of peripheral nerve injury treatment for nerve injuries with larger gaps. However, the direct suture is limited by heavy tension at the suture sites, and the autologous nerve graft also has the drawbacks of donor site morbidity and insufifcient donor tissue. Recently, artiifcial nerve conduits have been developed as an alternative for clinical nerve repair to overcome the limitations associated with the above treatments. In order to further improve the efifciency of nerve conduits, various guidance cues are incorporated, including physical cues, biochemical signals, as well as support cells. First, this paper reviewed the contact guidance cues applied in nerve conduits, such as lumen ifllers, multi-channels and micro-patterns on the inner surface. Then, the paper focused on the polymeric nerve conduits with micro inner grooves. The polymeric nerve conduits were fabricated using the phase inversion-based ifber spinning techniques. The smart spinneret with grooved die was designed in the spinning platform, while different spinning conditions, including flow rates, air-gap distances, and polymer concentrations, were adjusted to investigate the inlfuence of fabrication conditions on the geometry of nerve conduits. The inner groove size in the nerve conduits can be precisely controlled in our hollow ifber spinning process, which can work as the efifcient contact guidance cue for nerve regeneration.

  4. Visualization of conduit-matrix conductivity differences in a karst aquifer using time-lapse electrical resistivity

    Science.gov (United States)

    Meyerhoff, Steven B.; Karaoulis, Marios; Fiebig, Florian; Maxwell, Reed M.; Revil, André; Martin, Jonathan B.; Graham, Wendy D.

    2012-12-01

    In the karstic upper Floridan aquifer, surface water flows into conduits of the groundwater system and may exchange with water in the aquifer matrix. This exchange has been hypothesized to occur based on differences in discharge at the Santa Fe River Sink-Rise system, north central Florida, but has yet to be visualized using any geophysical techniques. Using electrical resistivity tomography, we conducted a time-lapse study at two locations with mapped conduits connecting the Santa Fe River Sink to the Santa Fe River Rise to study changes of electrical conductivity during times of varying discharge over a six-week period. Our results show conductivity differences between matrix, conduit changes in resistivity occurring through time at the locations of mapped karst conduits, and changes in electrical conductivity during rainfall infiltration. These observations provide insight into time scales and matrix conduit conductivity differences, illustrating how surface water flow recharged to conduits may flow in a groundwater system in a karst aquifer.

  5. Odontologie im numismatischen Spiegel : Ein Beitrag zur Geschichte der Zahnheilkunde

    OpenAIRE

    Heckert, Gerold Rüdiger

    2006-01-01

    Obgleich Medaillen mit zahnheilkundlichen Motiven schon sehr lange vertreten sind, hat dies in der Literatur bisher wenig Beachtung gefunden. Eine eigenständige Veröffentlichung erschien 1988 herausgegeben von Ladendorf und Salaschek (Proskauer 1940), die sich aber nur mit der Reklame von Zahnärzten und für Zahnärzte auf Medaillen befasst. Dieser Publikation liegt die Zusammenstellung von Storer und der Katalog zur Sammlung Brettauer zu Grunde. In den USA führte der Gynäkologe Horatio...

  6. Technische Feuchtgebiete zur Nachreinigung von Abwasser:Stickstoff, Abwasserdesinfektion, Spurenstoffe

    OpenAIRE

    Rühmland, Sabine

    2015-01-01

    Stickstoff, Spurenstoffe und Krankheitserreger können auch in geringen Mengen Schäden in Gewässern bzw. beim Menschen verursachen. In dieser Arbeit soll geklärt werden, inwieweit das naturnahe Abwasserreinigungsverfahren der technischen Feuchtgebiete zur Nachreinigung von Abwasser geeignet ist. Dafür wurden in Berlin sieben bewachsene Bodenfilter und Abwasserteiche im techni-schen Maßstab einer Kläranlage mit Nährstoffelimination nachgeschaltet. Ein Sandfilter, ein Sandfilter mit Lehm und...

  7. Präanalytik zur HCMV-Diagnostik

    OpenAIRE

    Travers-Podmaniczky, Gabrielle

    2011-01-01

    Die kongenitale HCMV-Infektion ist der wichtigste Auslöser geistiger Retardierung viraler Genese und ist für die meisten neurosensorischen Hörstörungen nicht genetischen Ursprunges verantwortlich. Die Entwicklung neuer Strategien zur Prävention der HCMV-Infektion bei Neugeborenen ist also von höchster Dringlichkeit. Die Einführung von universellen Screeningprogrammen bei Neugeborenen könnte die frühzeitige Erkennung einer Infektion und somit einen frühen therapeutischen Einsatz ermöglichen. U...

  8. Migration und differenzierte Citizenship : Zur Post-Amerikanisierung Europas

    OpenAIRE

    Cattacin, Sandro

    2006-01-01

    Während sich Frankreich in Kopftuchdebatten in den Schulen auf seine Wurzeln rückbesinnen möchte, Deutschland an der Operationalisierung der Leitkultur herumbastelt und sich Forscherscharen an der politisch gestellten Frage abmühen, was „Integration“ bedeute, schreitet die Pluralisierung unserer Gesellschaft unbekümmert weiter. Diese Pluralisierung, die nur bedingt auf Migration zurückzuführen ist, fordert die europäischen nationalen Gesellschaften dreifach heraus. Erstens durch die ständige ...

  9. Structures and lithofacies of inferred silicic conduits in the Paraná-Etendeka LIP, southernmost Brazil

    Science.gov (United States)

    Simões, M. S.; Lima, E. F.; Sommer, C. A.; Rossetti, L. M. M.

    2018-04-01

    Extensive silicic units in the Paraná-Etendeka LIP have been long interpreted as pyroclastic density currents (rheomorphic ignimbrites) derived from the Messum Complex in Namibia. In recent literature, however, they have been characterized as effusive lava flows and domes. In this paper we describe structures and lithofacies related to postulated silicic lava feeder conduits at Mato Perso, São Marcos and Jaquirana-Cambará do Sul areas in southern Brazil. Inferred conduits are at least 15-25 m in width and the lithofacies include variably vesicular monomictic welded and non-welded breccias in the margins to poorly vesicular, banded, spherulitic and microfractured vitrophyres in the central parts. Flat-lying coherent vitrophyres and massive obsidian are considered to be the subaerial equivalents of the conduits. Large-scale, regional tectonic structures in southern Brazil include the NE-SW aligned Porto Alegre Suture, Leão and Açotea faults besides the Antas Lineament, a curved tectonic feature accompanying the bed of Antas river. South of the Antas Lineament smaller-scale, NW-SE lineaments limit the exposure areas of the inferred conduits. NE-SW and subordinate NW-SE structures within this smaller-scale lineaments are represented by the main postulated conduit outcrops and are parallel to the dominant sub-vertical banding in the widespread banded vitrophyre lithofacies. Upper lava flows display flat-lying foliation, pipe-like and spherical vesicles and have better developed microlites. Petrographic characteristics of the silicic vitrophyres indicate that crystal-poor magmas underwent distinct cooling paths for each inferred conduit area. The vitrophyre chemical composition is defined by the evolution of trachydacitic/dacitic vitrophyres with 62-65 wt% SiO2 to rhyodacite and rhyolite with 66-68 wt% SiO2. The more evolved rocks are assigned to the latest intrusive grey vitrophyre outcropping in the center of the conduits. Degassing pathways formed during

  10. Vom Referat bis zur Examensarbeit: Naturwissenschaftliche Texte perfekt verfassen und gestalten

    Science.gov (United States)

    Kremer, Bruno P.

    Welches Thema eignet sich für mein Referat oder meine Seminararbeit? Wie sammle ich Stoff? Wie gliedere ich den Text? Bruno P. Kremer beantwortet auf nur 200 Seiten alle wichtigen Fragen zur wissenschaftlichen Arbeit in den naturwissenschaftlichen Fächern. Dabei beschränkt er sich auf das für Studenten und Schüler wirklich notwendige Wissen und lässt jeglichen unnützen Ballast beiseite. Dieser praktische Ratgeber verhilft Ihnen zur erfolgreichen wissenschaftlichen Arbeit - vom Referat bis zur Examensarbeit.

  11. The components of the unique Zur regulon of Cupriavidus metallidurans mediate cytoplasmic zinc handling.

    Science.gov (United States)

    Bütof, Lucy; Schmidt-Vogler, Christopher; Herzberg, Martin; Große, Cornelia; Nies, Dietrich H

    2017-08-14

    Zinc is an essential trace element and at the same time it is toxic at high concentrations. In the beta-proteobacterium Cupriavidus metallidurans the highly efficient removal of surplus zinc from the periplasm is responsible for its outstanding metal resistance. Rather than having a typical Zur-dependent, high-affinity ATP-binding cassette transporter of the ABC protein superfamily for zinc uptake at low concentrations, C. metallidurans instead has the secondary zinc importer ZupT of the ZRT/IRT (ZIP) family. It is important to understand, therefore, how this zinc-resistant bacterium copes when it is exposed to low zinc concentrations. Members of the Zur regulon in C. metallidurans were identified by comparing the transcriptomes of a Δ zur mutant and its parent strain. The consensus sequence of the Zur-binding box was derived for the zupTp promoter-regulatory region using a truncation assay. The motif was used to predict possible Zur-boxes upstream of Zur regulon members. Binding of Zur to these boxes was confirmed. Two Zur-boxes upstream of the cobW 1 gene, encoding a putative zinc chaperone, proved to be required for complete repression of cobW 1 and its downstream genes in cells cultivated in mineral salts medium. A Zur box upstream of each of zur-cobW 2 , cobW 3 and zupT permitted low-expression level of these genes plus their up-regulation under zinc starvation conditions. This demonstrates a compartmentalization of zinc homeostasis in C. metallidurans with the periplasm being responsible for removal of surplus zinc and cytoplasmic components for management of zinc as an essential co-factor, with both compartments connected by ZupT. Importance Elucidating zinc homeostasis is necessary to understand both host-pathogen interactions and performance of free-living bacteria in their natural environment. Escherichia coli acquires zinc under low zinc concentrations by the Zur-controlled ZnuABC importer of the ABC superfamily, and this was also the paradigm for other

  12. Uncovering Offshore Financial Centers: Conduits and Sinks in the Global Corporate Ownership Network.

    Science.gov (United States)

    Garcia-Bernardo, Javier; Fichtner, Jan; Takes, Frank W; Heemskerk, Eelke M

    2017-07-24

    Multinational corporations use highly complex structures of parents and subsidiaries to organize their operations and ownership. Offshore Financial Centers (OFCs) facilitate these structures through low taxation and lenient regulation, but are increasingly under scrutiny, for instance for enabling tax avoidance. Therefore, the identification of OFC jurisdictions has become a politicized and contested issue. We introduce a novel data-driven approach for identifying OFCs based on the global corporate ownership network, in which over 98 million firms (nodes) are connected through 71 million ownership relations. This granular firm-level network data uniquely allows identifying both sink-OFCs and conduit-OFCs. Sink-OFCs attract and retain foreign capital while conduit-OFCs are attractive intermediate destinations in the routing of international investments and enable the transfer of capital without taxation. We identify 24 sink-OFCs. In addition, a small set of five countries - the Netherlands, the United Kingdom, Ireland, Singapore and Switzerland - canalize the majority of corporate offshore investment as conduit-OFCs. Each conduit jurisdiction is specialized in a geographical area and there is significant specialization based on industrial sectors. Against the idea of OFCs as exotic small islands that cannot be regulated, we show that many sink and conduit-OFCs are highly developed countries.

  13. Small-sized conduits in the right ventricular outflow tract in young children: bicuspidalized homografts are a good alternative to standard conduits.

    Science.gov (United States)

    François, Katrien; De Groote, Katya; Vandekerckhove, Kristof; De Wilde, Hans; De Wolf, Daniel; Bové, Thierry

    2017-10-03

    Downsizing a homograft (HG) through bicuspidalization has been used for more than 2 decades to overcome the shortage of small-sized conduits for reconstruction of the right ventricular outflow tract (RVOT) in young children. Our goal was to investigate the durability of bicuspidalized HGs compared with other small HGs. A retrospective analysis of 93 conduits ≤20 mm, implanted over 23 years, was performed. The end-points were survival, structural valve degeneration and conduit replacement. The conduits comprised 40 pulmonary HGs, 12 aortic HGs, 17 bicuspidalized HGs and 24 xenografts. The median age, mean conduit diameter and z-value at implantation were 1.4 (interquartile range 0.3-3) years, 16.5 ± 2.7 mm and 2.8 ± 1.3, respectively. Valve position was heterotopic in 59 patients and orthotopic in 34 patients. At a mean follow-up period of 7.6 ± 5.9 years, the hospital survival rate was 89%. Freedom from explant at 5 and 10 years was 83 ± 5% and 52 ± 6%, respectively. Freedom from structural valve degeneration was 79 ± 5% at 5 years and 47 ± 6% at 10 years [68 ± 8% for pulmonary HG, 42 ± 16% for bicuspidalized HG, 31 ± 15% for aortic HG and 20 ± 9% for xenografts (log rank P right ventricular outflow tract conduit in young children. However, when a small pulmonary HG is unavailable, bicuspidalization offers a valid alternative, preferable to xenograft conduits, at mid-term follow-up. © The Author 2017. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

  14. Shallow conduit processes of the 1991 Hekla eruption, Iceland

    Science.gov (United States)

    Gudnason, J.; Thordarson, T.; Houghton, B. F.

    2013-12-01

    On January 17, 1991 at 17:00 hrs, the 17th eruption of Hekla since 1104AD began. Lasting for almost two months, it produced 0.02 km3 of icelandite tephra and ~0.15km3 of icelandite lava. This eruption was the third of four eruptions since 1980 with a recurrence period of approximately 10 years, as opposed to a recurrence interval of c. 55 years for the eruptions in the period 1104AD to 1947AD. [1] The last four Hekla eruptions are typified by a 0.5-2 hour-long initial phase of subplinian intensity and discharge ranging from 2900-6700 m3/s [2]. In all 4 events the inital phase was followed by a sustained and relatively low-discharge(sorted tephra fall covering >20,000 km2. Here we examine the first phase of the Hekla 1991 eruption with focus on vesiculation and fragmentation processes in the shallow conduit and ash production. Samples of the tephra fall were collected on snow immediately after the initial phase at multiple sites providing a representative spatial coverage within the 0.1mm isopach [3]. This set was augmented by samples collected in 2012 to provide tighter coverage of near vent region. Grain size of all samples has been measured down to 1 micron. Density measurements have been conducted on 4 near-vent pumice samples (100 clasts each) and the pumice vesicle size distribution has been determined in a selected subset of clasts. The reconstructed whole deposit grain size distribution exhibits a unimodal, log-normal distribution peaking at -3 phi, typical of dry, magmatic fragmentation. Pumice densities range from 520-880 kg/m3 and exhibit a tight unimodal and log-normal distribution indicating a mean vesicularity of 77% to 79% for the magma erupted during the initial phase. Along with preliminary results for bubble number density and vesicle size distribution this implies a single late-stage homogeneous bubble nucleation and very uniform conditions of magma fragmentation during this short-lived initial phase of the Hekla 1991 eruption. 1. Gudmundsson, A

  15. The Use of Degradable Nerve Conduits for Human Nerve Repair: A Review of the Literature

    Directory of Open Access Journals (Sweden)

    M. F. Meek

    2005-01-01

    Full Text Available The management of peripheral nerve injury continues to be a major clinical challenge. The most widely used technique for bridging defects in peripheral nerves is the use of autologous nerve grafts. This technique, however, has some disadvantages. Many alternative experimental techniques have thus been developed, such as degradable nerve conduits. Degradable nerve guides have been extensively studied in animal experimental studies. However, the repair of human nerves by degradable nerve conduits has been limited to only a few clinical studies. In this paper, an overview of the available international published literature on degradable nerve conduits for bridging human peripheral nerve defects is presented for literature available until 2004. Also, the philosophy on the use of nerve guides and nerve grafts is given.

  16. Transverse colon conduit urinary diversion in patients treated with very high dose pelvic irradiation

    International Nuclear Information System (INIS)

    Ravi, R.; Dewan, A.K.; Pandey, K.K.

    1994-01-01

    Urinary diversion may be required in patients receiving pelvic irradiation for gynaecological or genitourinary cancers either as part of a planned or salvage surgical procedure or for urological complications of irradiation. Records were reviewed for 30 such patients who underwent transverse colon conduit as a primary form of urinary diversion. Most of the conduits were constructed using refluxing ureterocolic anastomoses with stents. The results showed no operative mortality. Although the procedure was associated with a complication rate of 37% and a re-operation rate of 20%, there were no bowel or urinary anastomotic leaks. The operation could be safely performed on patients with renal failure, with 83% of such patients showing normal or improved serum creatinine levels post operatively. The advantages of transverse colon conduit urinary diversion are the use of non-irradiated bowel and ureters for diversion. It is recommended as a primary form of urinary diversion in these high risk cases. (Author)

  17. Collagen-coated polylactic-glycolic acid (PLGA) seeded with neural-differentiated human mesenchymal stem cells as a potential nerve conduit.

    Science.gov (United States)

    Sulong, Ahmad Fadzli; Hassan, Nur Hidayah; Hwei, Ng Min; Lokanathan, Yogeswaran; Naicker, Amaramalar Selvi; Abdullah, Shalimar; Yusof, Mohd Reusmaazran; Htwe, Ohnmar; Idrus, Ruszymah Bt Hj; Haflah, Nor Hazla Mohamed

    2014-01-01

    Autologous nerve grafts to bridge nerve gaps pose various drawbacks. Nerve tissue engineering to promote nerve regeneration using artificial neural conduits has emerged as a promising alternative. To develop an artificial nerve conduit using collagen-coated polylactic-glycolic acid (PLGA) and to analyse the survivability and propagating ability of the neuro-differentiated human mesenchymal stem cells in this conduit. The PLGA conduit was constructed by dip-molding method and coated with collagen by immersing the conduit in collagen bath. The ultra structure of the conduits were examined before they were seeded with neural-differentiated human mesenchymal stem cells (nMSC) and implanted sub-muscularly on nude mice thighs. The non-collagen-coated PLGA conduit seeded with nMSC and non-seeded non-collagen-coated PLGA conduit were also implanted for comparison purposes. The survivability and propagation ability of nMSC was studied by histological and immunohistochemical analysis. The collagen-coated conduits had a smooth inner wall and a highly porous outer wall. Conduits coated with collagen and seeded with nMSCs produced the most number of cells after 3 weeks. The best conduit based on the number of cells contained within it after 3 weeks was the collagen-coated PLGA conduit seeded with neuro-transdifferentiated cells. The collagen-coated PLGA conduit found to be suitable for attachment, survival and proliferation of the nMSC. Minimal cell infiltration was found in the implanted conduits where nearly all of the cells found in the cell seeded conduits are non-mouse origin and have neural cell markers, which exhibit the biocompatibility of the conduits. The collagen-coated PLGA conduit is biocompatible, non-cytotoxic and suitable for use as artificial nerve conduits.

  18. Genipin-Cross-Linked Chitosan Nerve Conduits Containing TNF-α Inhibitors for Peripheral Nerve Repair.

    Science.gov (United States)

    Zhang, Li; Zhao, Weijia; Niu, Changmei; Zhou, Yujie; Shi, Haiyan; Wang, Yalin; Yang, Yumin; Tang, Xin

    2018-07-01

    Tissue engineered nerve grafts (TENGs) are considered a promising alternative to autologous nerve grafting, which is considered the "gold standard" clinical strategy for peripheral nerve repair. Here, we immobilized tumor necrosis factor-α (TNF-α) inhibitors onto a nerve conduit, which was introduced into a chitosan (CS) matrix scaffold utilizing genipin (GP) as the crosslinking agent, to fabricate CS-GP-TNF-α inhibitor nerve conduits. The in vitro release kinetics of TNF-α inhibitors from the CS-GP-TNF-α inhibitor nerve conduits were investigated using high-performance liquid chromatography. The in vivo continuous release profile of the TNF-α inhibitors released from the CS-GP-TNF-α inhibitor nerve conduits was measured using an enzyme-linked immunosorbent assay over 14 days. We found that the amount of TNF-α inhibitors released decreased with time after the bridging of the sciatic nerve defects in rats. Moreover, 4 and 12 weeks after surgery, histological analyses and functional evaluations were carried out to assess the influence of the TENG on regeneration. Immunochemistry performed 4 weeks after grafting to assess early regeneration outcomes revealed that the TENG strikingly promoted axonal outgrowth. Twelve weeks after grafting, the TENG accelerated myelin sheath formation, as well as functional restoration. In general, the regenerative outcomes following TENG more closely paralleled findings observed with autologous grafting than the use of the CS matrix scaffold. Collectively, our data indicate that the CS-GP-TNF-α inhibitor nerve conduits comprised an elaborate system for sustained release of TNF-α inhibitors in vitro, while studies in vivo demonstrated that the TENG could accelerate regenerating axonal outgrowth and functional restoration. The introduction of CS-GP-TNF-α-inhibitor nerve conduits into a scaffold may contribute to an efficient and adaptive immune microenvironment that can be used to facilitate peripheral nerve repair.

  19. FDG-PET identification of infected pulmonary artery conduit following tetralogy of fallot (TOF) repair

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yu Yang; Williams, Hadyn; Pucar, Darko [Dept. of Radiology, Medical College of Georgia, Augusta (United States)

    2017-03-15

    Tetralogy of Fallot (TOF) is one of the most common forms of cyanotic congenital heart disease usually managed by serial surgical repairs. The repaired prosthetic valve or conduit is susceptible to life-threatening infection. FDG-PET is an effective alternative to evaluate the source of infection when other examinations are inconclusive. We report an unusual case of an infected pulmonary artery conduit after TOF repair although the echocardiogram was negative for vegetation, which was later confirmed by surgery and pathology. The case highlights the role of FDG-PET as a problem-solving tool for potential endocarditis and cardiac device infection cases after complex cardiac surgery.

  20. The grain-size distribution of pyroclasts: Primary fragmentation, conduit sorting or abrasion?

    Science.gov (United States)

    Kueppers, U.; Schauroth, J.; Taddeucci, J.

    2013-12-01

    Explosive volcanic eruptions expel a mixture of pyroclasts and lithics. Pyroclasts, fragments of the juvenile magma, record the state of the magma at fragmentation in terms of porosity and crystallinity. The grain size distribution of pyroclasts is generally considered to be a direct consequence of the conditions at magma fragmentation that is mainly driven by gas overpressure in bubbles, high shear rates, contact with external water or a combination of these factors. Stress exerted by any of these processes will lead to brittle fragmentation by overcoming the magma's relaxation timescale. As a consequence, most pyroclasts exhibit angular shapes. Upon magma fragmentation, the gas pyroclast mixture is accelerated upwards and eventually ejected from the vent. The total grain size distribution deposited is a function of fragmentation conditions and transport related sorting. Porous pyroclasts are very susceptible to abrasion by particle-particle or particle-conduit wall interaction. Accordingly, pyroclastic fall deposits with angular clasts should proof a low particle abrasion upon contact to other surfaces. In an attempt to constrain the degree of particle interaction during conduit flow, monomodal batches of washed pyroclasts have been accelerated upwards by rapid decompression and subsequently investigated for their grain size distribution. In our set-up, we used a vertical cylindrical tube without surface roughness as conduit. We varied grain size (0.125-0.25; 0.5-1; 1-2 mm), porosity (0; 10; 30 %), gas-particle ratio (10 and 40%), conduit length (10 and 28 cm) and conduit diameter (2.5 and 6 cm). All ejected particles were collected after settling at the base of a 3.3 m high tank and sieved at one sieve size below starting size (half-Φ). Grain size reduction showed a positive correlation with starting grain size, porosity and overpressure at the vent. Although milling in a volcanic conduit may take place, porous pyroclasts are very likely to be a primary product

  1. Havery Mudd 2014-2015 Computer Science Conduit Clinic Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Aspesi, G [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Bai, J [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Deese, R [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Shin, L [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-05-12

    Conduit, a new open-source library developed at Lawrence Livermore National Laboratories, provides a C++ application programming interface (API) to describe and access scientific data. Conduit’s primary use is for inmemory data exchange in high performance computing (HPC) applications. Our team tested and improved Conduit to make it more appealing to potential adopters in the HPC community. We extended Conduit’s capabilities by prototyping four libraries: one for parallel communication using MPI, one for I/O functionality, one for aggregating performance data, and one for data visualization.

  2. A rare case of prosthetic endocarditis and dehiscence in a mechanical valved conduit.

    Science.gov (United States)

    Kannan, Arun; Smith, Cristy; Subramanian, Sreekumar; Janardhanan, Rajesh

    2014-02-07

    A middle-aged adult patient with a history of aortic root replacement with a mechanical valved conduit and remote chest trauma was referred to our institution with prosthetic endocarditis. Transoesophageal echocardiogram at our institution confirmed a near-complete dehiscence of the prosthetic aortic valve from the conduit, with significant perivalvular flow forming a pseudoaneurysm. The patient underwent a high-risk re-operation, involving redo aortic root replacement with a homograft after extensive debridement of the infected tissue. The patient was discharged to an outside facility after an uncomplicated hospital course, and remains stable.

  3. FDG-PET identification of infected pulmonary artery conduit following tetralogy of fallot (TOF) repair

    International Nuclear Information System (INIS)

    Zhang, Yu Yang; Williams, Hadyn; Pucar, Darko

    2017-01-01

    Tetralogy of Fallot (TOF) is one of the most common forms of cyanotic congenital heart disease usually managed by serial surgical repairs. The repaired prosthetic valve or conduit is susceptible to life-threatening infection. FDG-PET is an effective alternative to evaluate the source of infection when other examinations are inconclusive. We report an unusual case of an infected pulmonary artery conduit after TOF repair although the echocardiogram was negative for vegetation, which was later confirmed by surgery and pathology. The case highlights the role of FDG-PET as a problem-solving tool for potential endocarditis and cardiac device infection cases after complex cardiac surgery

  4. VLP seismicity from resonant modes of acoustic-gravity waves in a conduit-crack system filled with multiphase magma

    Science.gov (United States)

    Liang, C.; Prochnow, B. N.; OReilly, O. J.; Dunham, E. M.; Karlstrom, L.

    2016-12-01

    Oscillation of magma in volcanic conduits connected to cracks (dikes and sills) has been suggested as an explanation for very long period (VLP) seismic signals recorded at active basaltic volcanoes such as. Kilauea, Hawaii, and Erebus, Antarctica. We investigate the VLP seismicity using a linearized model for waves in and associated eigenmodes of a coupled conduit-crack system filled with multiphase magma, an extension of the Karlstrom and Dunham (2016) model for acoustic-gravity waves in volcanic conduits. We find that the long period surface displacement (as recorded on broadband seismometers) is dominated by opening/closing of the crack rather than the deformation of the conduit conduit walls. While the fundamental eigenmode is sensitive to the fluid properties and the geometry of the magma plumbing system, a closer scrutiny of various resonant modes reveals that the surface displacement is often more sensitive to higher modes. Here we present a systematic analysis of various long period acoustic-gravity wave resonant modes of a coupled conduit-crack system that the surface displacement is most sensitive to. We extend our previous work on a quasi-one-dimensional conduit model with inviscid magma to a more general axisymmetric conduit model that properly accounts for viscous boundary layers near the conduit walls, based on the numerical method developed by Prochnow et al. (submitted to Computers and Fluids, 2016). The surface displacement is dominated by either the fundamental or higher eigenmodes, depending on magma properties and the geometry of conduit and crack. An examination of the energetics of these modes reveals the complex interplay of different restoring forces (magma compressibility in the conduit, gravity, and elasticity of the crack) driving the VLP oscillations. Both nonequilibrium bubble growth and resorption and viscosity contribute to the damping of VLP signals. Our models thus provide a means to infer properties of open-vent basaltic volcanoes

  5. Biological conduits combining bone marrow mesenchymal stem cells and extracellular matrix to treat long-segment sciatic nerve defects

    Directory of Open Access Journals (Sweden)

    Yang Wang

    2015-01-01

    Full Text Available The transplantation of polylactic glycolic acid conduits combining bone marrow mesenchymal stem cells and extracellular matrix gel for the repair of sciatic nerve injury is effective in some respects, but few data comparing the biomechanical factors related to the sciatic nerve are available. In the present study, rabbit models of 10-mm sciatic nerve defects were prepared. The rabbit models were repaired with autologous nerve, a polylactic glycolic acid conduit + bone marrow mesenchymal stem cells, or a polylactic glycolic acid conduit + bone marrow mesenchymal stem cells + extracellular matrix gel. After 24 weeks, mechanical testing was performed to determine the stress relaxation and creep parameters. Following sciatic nerve injury, the magnitudes of the stress decrease and strain increase at 7,200 seconds were largest in the polylactic glycolic acid conduit + bone marrow mesenchymal stem cells + extracellular matrix gel group, followed by the polylactic glycolic acid conduit + bone marrow mesenchymal stem cells group, and then the autologous nerve group. Hematoxylin-eosin staining demonstrated that compared with the polylactic glycolic acid conduit + bone marrow mesenchymal stem cells group and the autologous nerve group, a more complete sciatic nerve regeneration was found, including good myelination, regularly arranged nerve fibers, and a completely degraded and resorbed conduit, in the polylactic glycolic acid conduit + bone marrow mesenchymal stem cells + extracellular matrix gel group. These results indicate that bridging 10-mm sciatic nerve defects with a polylactic glycolic acid conduit + bone marrow mesenchymal stem cells + extracellular matrix gel construct increases the stress relaxation under a constant strain, reducing anastomotic tension. Large elongations under a constant physiological load can limit the anastomotic opening and shift, which is beneficial for the regeneration and functional reconstruction of sciatic nerve. Better

  6. Semiokapitalismus und imperiale Kontrollgesellschaft Zur Digitalisierung der Produktion am Beginn des 21. Jahrhunderts

    Directory of Open Access Journals (Sweden)

    Wolfgang Neurath

    2014-12-01

    Full Text Available Wolfgang Neurath analysiert angesichts des kybernetischen Semiokapitalismus und des durch ihn entstandenen "Kognitariats" in welcher Art und Weise digitale Produktions- und Wertschöpfungsprozesse am Beginn des 21. Jahrhunderts zur Kontrolle eingesetzt werden ...

  7. Contributions to ecosystem research and environmental education III; Beitraege zur Oekosystemforschung und Umwelterziehung III

    Energy Technology Data Exchange (ETDEWEB)

    Erdmann, K H [ed.; Nauber, J [ed.

    1996-09-01

    The publication comprises the following chapters: Contributions to the implementation of findings in policy and administration; Contributions to biosphere reservations; Contributions to ecosystems research; Contributions to environmental education. The first chapter discusses environmental protection from the political point of view, while the second chapter describes biosphere reservations world-wide as well as their protection, conservation and development. (SR) [Deutsch] Die vorliegende Veroeffentlichung teilt sich in folgende Kapitel auf: Beitraege zur Umsetzung von Erkenntnissen in Politik und Verwaltung, Beitraege zu Biosphaerenreservaten, Beitraege zur Oekosystemforschung sowie Beitraege zur Umwelterziehung. Im ersten Kapitel wird der Umweltschutz von der politischen Seite aus beleuchtet. Das zweite Kapitel beschreibt verschiedene Biosphaerenreservate in der ganzen Welt und deren Schutz, Pflege und Entwicklung. Das dritte Kapitel beinhaltet Beitraege zur oekologischen Forschung. Abschliessend werden im letzten Kapitel psychologische Aspekte der Umwelterziehung dargestellt. (SR)

  8. Entwicklung und Anwendung neuer NMR-Methoden: Orientierungsmedien zur Strukturbestimmung mit anisotropen Parametern und Metabonomics

    OpenAIRE

    Büchler, Silke

    2014-01-01

    Das Ziel dieser Arbeit war die Entwicklung und Anwendung neuer Orientierungsmedien zur Strukturbestimmung mit anisotropen Parametern, sowie die Etablierung von Metabonomics-Studien an Flüssigzellkulturen und Reispflanzen.

  9. [Alfred Ritscher. Reval an der schwelle zur neuzeit. T. 2] / Paul Kaegbein

    Index Scriptorium Estoniae

    Kaegbein, Paul

    2006-01-01

    Arvustus: Ritscher, Alfred. Reval an der schwelle zur neuzeit. T. 2: Vom tode Wolters von Plettenberg bis zum Untergang des Deutschen Ordens in Livland (1535-1561). Bonn: Kulturstiftung der deutshen Vertriebenen 2001. (Historische Forschungen).

  10. Der gläserne Aschenbecher - oder - Zur Verallgemeinerung des Eulerschen Polyedersatzes

    OpenAIRE

    Gallin, P

    2009-01-01

    Eine Diskussion unter Mathematikern im Lehrerzimmer einer Kantonsschule führt zusammen mit Beiträgen der Schülerinnen und Schüler unversehens zu topologischen Einsichten, die normalerweise im Gymnasium nicht zur Sprache kommen.

  11. Altautoverwertung zwischen Staat und Markt: Bedingungen und Potentiale zur Modernisierung von Lagerhaltung und Marketing gebrauchter Autoteile

    OpenAIRE

    Lucas, Rainer

    2000-01-01

    Das Arbeitspapier diskutiert vor dem Hintergrund veränderter gesetzlicher Rahmen-und Wettbewerbsbedingungen in der Autoverwertung Ziele und Maßnahmen zurStärkung kleiner und mittelständischer Verwertungsbetriebe. Der Bereich GebrauchteAutoteile wird im Rahmen eines regionalen Fallbeispiels einer tiefergehenden Analyseunterzogen. Hieraus werden Vorschläge zur regionalen Netzwerkbildung innerhalb derBranche und neue Dienstleistungsperspektiven abgeleitet. Ein wesentliches Koope-rationsfeld ist ...

  12. Competitive Intelligence : Aufbau einer Informationsbasis und Entscheidungssystematik zur Definition strategischer Zielmärkte

    OpenAIRE

    Maffenbeier, Sina

    2010-01-01

    Im Rahmen der Globalisierung und des daraus resultierenden Wettbewerbs ist es für ein Unternehmen von zentraler Bedeutung, Wissen über die Wettbewerbssituation zu erhalten. Nicht nur zur Erschließung neuer Märkte, sondern auch zur Sicherung der Unternehmensexistenz ist eine Wettbewerbsanalyse unabdingbar. Konkurrenz- bzw. Wettbewerbsforschung wird überwiegend als „Competitive Intelligence“ bezeichnet. In diesem Sinne beschäftigt sich die vorliegende Bachelorarbeit mit einem Bereich von Compet...

  13. Improved axonal regeneration of transected spinal cord mediated by multichannel collagen conduits functionalized with neurotrophin-3 gene.

    Science.gov (United States)

    Yao, L; Daly, W; Newland, B; Yao, S; Wang, W; Chen, B K K; Madigan, N; Windebank, A; Pandit, A

    2013-12-01

    Functionalized biomaterial scaffolds targeted at improving axonal regeneration by enhancing guided axonal growth provide a promising approach for the repair of spinal cord injury. Collagen neural conduits provide structural guidance for neural tissue regeneration, and in this study it is shown that these conduits can also act as a reservoir for sustained gene delivery. Either a G-luciferase marker gene or a neurotrophin-3-encoding gene, complexed to a non-viral, cyclized, PEGylated transfection vector, was loaded within a multichannel collagen conduit. The complexed genes were then released in a controlled fashion using a dual release system both in vitro and in vivo. For evaluation of their biological performance, the loaded conduits were implanted into the completely transected rat thoracic spinal cord (T8-T10). Aligned axon regeneration through the channels of conduits was observed one month post-surgery. The conduits delivering neurotrophin-3 polyplexes resulted in significantly increased neurotrophin-3 levels in the surrounding tissue and a statistically higher number of regenerated axons versus the control conduits (P<0.05). This study suggests that collagen neural conduits delivering a highly effective non-viral therapeutic gene may hold promise for repair of the injured spinal cord.

  14. A novel balloon assisted two-stents telescoping technique for repositioning an embolized stent in the pulmonary conduit.

    Science.gov (United States)

    Kobayashi, Daisuke; Gowda, Srinath T; Forbes, Thomas J

    2014-08-01

    A 9-year-old male, with history of pulmonary atresia and ventricular septal defect, status post complete repair with a 16 mm pulmonary homograft in the right ventricular outflow tract (RVOT) underwent 3110 Palmaz stent placement for conduit stenosis. Following deployment the stent embolized proximally into the right ventricle (RV). We undertook the choice of repositioning the embolized stent into the conduit with a transcatheter approach. Using a second venous access, the embolized stent was carefully maneuvered into the proximal part of conduit with an inflated Tyshak balloon catheter. A second Palmaz 4010 stent was deployed in the distal conduit telescoping through the embolized stent. The Tyshak balloon catheter was kept inflated in the RV to stabilize the embolized stent in the proximal conduit until it was successfully latched up against the conduit with the deployment of the overlapping second stent. One year later, he underwent Melody valve implantation in the pre-stented conduit relieving conduit insufficiency. This novel balloon assisted two-stents telescoping technique is a feasible transcatheter option to secure an embolized stent from the RV to the RVOT. © 2014 Wiley Periodicals, Inc.

  15. Nitric oxide permits hypoxia-induced lymphatic perfusion by controlling arterial-lymphatic conduits in zebrafish and glass catfish

    DEFF Research Database (Denmark)

    Dahl Ejby Jensen, Lasse; Cao, Renhai; Hedlund, Eva-Maria

    2009-01-01

    and lymphatic perfusion. Here we show in the adult zebrafish and glass catfish (Kryptopterus bicirrhis) that blood-lymphatic conduits directly connect arterial vessels to the lymphatic system. Under hypoxic conditions, arterial-lymphatic conduits (ALCs) became highly dilated and linearized by NO...

  16. Design and production of stopper made of concrete foam composite used for open channel conduit cover and parking bumper

    Science.gov (United States)

    Syam, Bustami; Sebayang, Alexander; Sebayang, Septian; Muttaqin, Maraghi; Darmadi, Harry; Basuki, WS; Sabri, M.; Abda, S.

    2018-03-01

    Open channel conduit is designed and produced with the aims to reduce excess water, whether from rain, seepage, or excess irrigation water in an area. It is also included in one of the important components of urban infrastructure in tackling the problem of flooding and waterlogging. On the roadway, e.g. housing complex the open channel conduits should function the same, however conduit covers are needed. The covers should be also designed to function as parking bumper. This paper discusses the design and production of the stoppers using our newly invented materials; the stoppers are structurally tested under static, dynamic, and bump test. Response of the conduit cover are found from structural analysis using finite element software ANSYS MECHANICAL version 17.5. Two types of stoppers are introduced: flat and curvy configuration. It was obtained that both types are suitable for open channel conduit cover and parking bumper.

  17. A Physicochemically Optimized and Neuroconductive Biphasic Nerve Guidance Conduit for Peripheral Nerve Repair.

    Science.gov (United States)

    Ryan, Alan J; Lackington, William A; Hibbitts, Alan J; Matheson, Austyn; Alekseeva, Tijna; Stejskalova, Anna; Roche, Phoebe; O'Brien, Fergal J

    2017-12-01

    Clinically available hollow nerve guidance conduits (NGCs) have had limited success in treating large peripheral nerve injuries. This study aims to develop a biphasic NGC combining a physicochemically optimized collagen outer conduit to bridge the transected nerve, and a neuroconductive hyaluronic acid-based luminal filler to support regeneration. The outer conduit is mechanically optimized by manipulating crosslinking and collagen density, allowing the engineering of a high wall permeability to mitigate the risk of neuroma formation, while also maintaining physiologically relevant stiffness and enzymatic degradation tuned to coincide with regeneration rates. Freeze-drying is used to seamlessly integrate the luminal filler into the conduit, creating a longitudinally aligned pore microarchitecture. The luminal stiffness is modulated to support Schwann cells, with laminin incorporation further enhancing bioactivity by improving cell attachment and metabolic activity. Additionally, this biphasic NGC is shown to support neurogenesis and gliogenesis of neural progenitor cells and axonal outgrowth from dorsal root ganglia. These findings highlight the paradigm that a successful NGC requires the concerted optimization of both a mechanical support phase capable of bridging a nerve defect and a neuroconductive phase with an architecture capable of supporting both Schwann cells and neurons in order to achieve functional regenerative outcome. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. Impact of bed rest on conduit artery remodeling: effect of exercise countermeasures.

    NARCIS (Netherlands)

    Duijnhoven, N.T.L. van; Green, D.J.; Felsenberg, D.; Belavy, D.L.; Hopman, M.T.E.; Thijssen, D.H.J.

    2010-01-01

    Physical inactivity is a potent stimulus for vascular remodeling, leading to a marked decrease in conduit artery diameter. However, little is known about the impact of physical inactivity on artery wall thickness or wall:lumen ratio or the potential of exercise countermeasures to modify artery wall

  19. The Railway and the River: Conduits of Dickens’s Imaginary City

    NARCIS (Netherlands)

    Moore, B.; Murail, E.; Thornton, S.

    2017-01-01

    This chapter analyses the railway and the river as two key conduits of Dickens’ imaginary city, arguing that each simultaneously connects and fractures the modern urban world that he depicts. Focusing on Dombey and Son and Our Mutual Friend, the chapter explores how railway and river combine

  20. Phase separation phenomena in branching conduits. Topical report Dec 78-Dec 81

    International Nuclear Information System (INIS)

    Saba, N.; Lahey, R.T. Jr.

    1982-03-01

    The analysis of Light Water Reactor (LWR) Loss-of-Coolant Accidents (LOCA's) requires that one be able to accurately calculate the two-phase flow splits in complex, branching conduits. The purpose of this study is to provide a general method for calculating the phase separation in a branching conduit. The degree of phase separation of a two-phase (air/water) mixture flowing through a plexiglas tee test section was measured. In addition, flow visualization, using high speed photography, was performed. The experimental design considerations, error analysis and the dependence of the observed phase separation on global parameters, such as inlet quality, mass flux and separation angle, are discussed. The pressure gradients were measured along the various conduits and the differential pressure was obtained at the tee junction by extrapolation. It was found that the degree of phase separation was quite pronounced, with the vapor phase preferentially separating into the branch. Using these data, a physically-based empirical model was developed with which to calculate the phasic distribution of a subsonic two-phase mixture in the downstream branches of a branching conduit

  1. 3D Bioprinting of Heterogeneous Aortic Valve Conduits with Alginate/Gelatin Hydrogels

    Science.gov (United States)

    Duan, Bin; Hockaday, Laura A.; Kang, Kevin H.; Butcher, Jonathan T.

    2013-01-01

    Heart valve disease is a serious and growing public health problem for which prosthetic replacement is most commonly indicated. Current prosthetic devices are inadequate for younger adults and growing children. Tissue engineered living aortic valve conduits have potential for remodeling, regeneration, and growth, but fabricating natural anatomical complexity with cellular heterogeneity remain challenging. In the current study, we implement 3D bioprinting to fabricate living alginate/gelatin hydrogel valve conduits with anatomical architecture and direct incorporation of dual cell types in a regionally constrained manner. Encapsulated aortic root sinus smooth muscle cells (SMC) and aortic valve leaflet interstitial cells (VIC) were viable within alginate/gelatin hydrogel discs over 7 days in culture. Acellular 3D printed hydrogels exhibited reduced modulus, ultimate strength, and peak strain reducing slightly over 7-day culture, while the tensile biomechanics of cell-laden hydrogels were maintained. Aortic valve conduits were successfully bioprinted with direct encapsulation of SMC in the valve root and VIC in the leaflets. Both cell types were viable (81.4±3.4% for SMC and 83.2±4.0% for VIC) within 3D printed tissues. Encapsulated SMC expressed elevated alpha-smooth muscle actin when printed in stiff matrix, while VIC expressed elevated vimentin in soft matrix. These results demonstrate that anatomically complex, heterogeneously encapsulated aortic valve hydrogel conduits can be fabricated with 3D bioprinting. PMID:23015540

  2. Enhancing Peripheral Nerve Regeneration with a Novel Drug-Delivering Nerve Conduit

    Science.gov (United States)

    2015-10-01

    our novel nerve conduit. 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 19a. NAME OF RESPONSIBLE...growth in dorsal root ganglion ( DRG ) cell culture Tasks/Subtasks: 1. In Vitro NGF/GNDF release kinetics experiments.......................... (Gale...Axonal growth of DRGs ................................................................ (Terry, Shea) (11-18months) Progress: We have started these

  3. Percutaneous transthoracic computed tomography-guided AICD insertion in a patient with extracardiac Fontan conduit.

    LENUS (Irish Health Repository)

    Murphy, Darra T

    2011-02-01

    Percutaneous pulmonary venous atrial puncture was performed under computed tomography guidance to successfully place an automated implantable cardiac defibrillator into a 26-year-old patient with extracardiac Fontan conduit who had presented with two out-of-hospital cardiac arrests. The procedure avoided the need for lead placement at thoracotomy.

  4. 76 FR 53678 - Calleguas Municipal Water District Notice of Surrender of Exemption (Conduit)

    Science.gov (United States)

    2011-08-29

    ... Municipal Water District Notice of Surrender of Exemption (Conduit) Pursuant to section 4.95(a) of the Commission's regulations,\\1\\ Calleguas Municipal Water District filed with the Commission a petition to... Municipal Water District, 87 FERC ] 62,256 (1999). \\3\\ See filing of July 11, 2011 by Calleguas Municipal...

  5. Recommended procedure for selection of detector systems for in vivo measurement of incorporated radioactivity; Empfehlungen zur Auswahl von Detektorsystemen zur Direktmessung der Koerperaktivitaet

    Energy Technology Data Exchange (ETDEWEB)

    Sahre, P. [Verein fuer Kernverfahrenstechnik und Analytik (VKTA) Rossendorf e.V., Dresden (Germany); Wahl, W. [GSF Forschungszentrum fuer Umwelt und Gesundheit, Neuherberg (Germany). Inst. fuer Strahlenschutz; Doerfel, H. [Forschungszentrum Karlsruhe GmbH (Germany)

    1997-12-01

    The paper presents and discusses a variety of aspects and objectives to be considered and explains the selection criteria to be applied with reference to the available detector systems. All available detector systems are shown and explained in a table. (orig./CB) [Deutsch] Zur Direktmessung der Koerperaktivitaet werden vorwiegend Halbleiter- und Szintillationsdetektoren verwendet. Bei Halbleiterdetektoren kommen der Regel HPGe-Detektoren und in Einzelfaellen auch Si(Li)-Detektoren zum Einsatz. Bei Szintillationsdetektoren werden hauptsaechlich NaI(TI)-Detektoren sowie NaI(TI)/CsI(TI)-Phoswich-Detektoren verwendet. Verschiedene Gesichtspunkte zur Auswahl von Detektorsystemen werden vorgestellt. (orig./SR)

  6. Tile drainage as karst: Conduit flow and diffuse flow in a tile-drained watershed

    Science.gov (United States)

    Schilling, K.E.; Helmers, M.

    2008-01-01

    The similarity of tiled-drained watersheds to karst drainage basins can be used to improve understanding of watershed-scale nutrient losses from subsurface tile drainage networks. In this study, short-term variations in discharge and chemistry were examined from a tile outlet collecting subsurface tile flow from a 963 ha agricultural watershed. Study objectives were to apply analytical techniques from karst springs to tile discharge to evaluate water sources and estimate the loads of agricultural pollutants discharged from the tile with conduit, intermediate and diffuse flow regimes. A two-member mixing model using nitrate, chloride and specific conductance was used to distinguish rainwater versus groundwater inputs. Results indicated that groundwater comprised 75% of the discharge for a three-day storm period and rainwater was primarily concentrated during the hydrograph peak. A contrasting pattern of solute concentrations and export loads was observed in tile flow. During base flow periods, tile flow consisted of diffuse flow from groundwater sources and contained elevated levels of nitrate, chloride and specific conductance. During storm events, suspended solids and pollutants adhered to soil surfaces (phosphorus, ammonium and organic nitrogen) were concentrated and discharged during the rapid, conduit flow portion of the hydrograph. During a three-day period, conduit flow occurred for 5.6% of the time but accounted for 16.5% of the total flow. Nitrate and chloride were delivered primarily with diffuse flow (more than 70%), whereas 80-94% of total suspended sediment, phosphorus and ammonium were exported with conduit and intermediate flow regimes. Understanding the water sources contributing to tile drainage and the manner by which pollutant discharge occurs from these systems (conduit, intermediate or diffuse flow) may be useful for designing, implementing and evaluating non-point source reduction strategies in tile-drained landscapes. ?? 2007 Elsevier B.V. All

  7. Thoracoscopic management of volvulus of the gastric conduit following minimally invasive Ivor-Lewis esophagectomy.

    Science.gov (United States)

    Linson, Jeremy; Latzko, Michael; Ahmed, Bestoun; Awad, Ziad

    2016-07-01

    We present a case of emergent thoracoscopic management of volvulus of the gastric conduit following minimally invasive Ivor-Lewis esophagectomy. The patient is a 69-year-old Caucasian male with a history of adenocarcinoma of the lower third of the esophagus. Initial presentation was dysphagia with solid foods, which progressed in severity until he was unable to swallow anything. EUS demonstrated a partially obstructing mass at 33 cm; biopsy revealed poorly differentiated adenocarcinoma, stage T3N2Mx. PET scan did not reveal any metastatic disease. Preoperative management included neo-adjuvant chemoradiation therapy (5-FU and cisplatin) and early placement of a jejunal feeding tube. Intra-operative leak test was performed as a matter of routine following completion of the esophagogastric anastomosis. A nasogastric tube was placed intra-operatively and removed on POD2 according to our standard pathway. Postoperatively, the patient progressed without difficulty to POD4, when we routinely obtain an upper GI swallow study. This demonstrated a lack of transit of contrast through the distal neo-esophagus. Follow-up endoscopy revealed volvulus of the gastric conduit with obliteration of the lumen. We immediately took the patient to the OR for thoracoscopic detorsion, which we accomplished successfully by entering the existing trochar sites and using blunt dissection.␣Upon entering the thoracic cavity, the staple line that had been oriented anteriorly was now posterior. Attachments were gently teased away from the chest wall and the conduit was detorsed and anchored to the chest wall in the correct orientation with silk suture. Intra-operative endoscopy demonstrated a patent conduit. Postoperative upper GI fluoroscopy now showed good transit of contrast. The patient continued to improve and was eventually advanced to mechanical soft diet and discharged on postoperative day 9. Early intervention is indicated in cases of volvulus of the gastric conduit following Ivor

  8. Ilse von zur Mühlen. Glanz und Elend. Mythos und Wirklichkeit der Herrenhäuser im Baltikum. Begleitpublikation zur gleichnahmigen Ausstellung des Ostpreußischen Landesmuseums und der Carl-Schirren-Gesellschaft e.V. / Anja Wilhelmi

    Index Scriptorium Estoniae

    Wilhelmi, Anja, 1966-

    2014-01-01

    Arvustus: Mühlen, Ilse von zur. Glanz und Elend. Mythos und Wirklichkeit der Herrenhäuser im Baltikum. Begleitpublikation zur gleichnahmigen Ausstellung des Ostpreußischen Landesmuseums und der Carl-Schirren-Gesellschaft e.V. (1. Dezember 2012 bis 14. April 2013), Lindenberg i. Allgäu 2012

  9. Interstage evaluation of homograft-valved right ventricle to pulmonary artery conduits for palliation of hypoplastic left heart syndrome.

    Science.gov (United States)

    Sandeep, Nefthi; Punn, Rajesh; Balasubramanian, Sowmya; Smith, Shea N; Reinhartz, Olaf; Zhang, Yulin; Wright, Gail E; Peng, Lynn F; Wise-Faberowski, Lisa; Hanley, Frank L; McElhinney, Doff B

    2018-04-01

    Palliation of hypoplastic left heart syndrome with a standard nonvalved right ventricle to pulmonary artery conduit results in an inefficient circulation in part due to diastolic regurgitation. A composite right ventricle pulmonary artery conduit with a homograft valve has a hypothetical advantage of reducing regurgitation, but may differ in the propensity for stenosis because of valve remodeling. This retrospective cohort study included 130 patients with hypoplastic left heart syndrome who underwent a modified stage 1 procedure with a right ventricle to pulmonary artery conduit from 2002 to 2015. A composite valved conduit (cryopreserved homograft valve anastomosed to a polytetrafluoroethylene tube) was placed in 100 patients (47 aortic, 32 pulmonary, 13 femoral/saphenous vein, 8 unknown), and a nonvalved conduit was used in 30 patients. Echocardiographic functional parameters were evaluated before and after stage 1 palliation and before the bidirectional Glenn procedure, and interstage interventions were assessed. On competing risk analysis, survival over time was better in the valved conduit group (P = .040), but this difference was no longer significant after adjustment for surgical era. There was no significant difference between groups in the cumulative incidence of bidirectional Glenn completion (P = .15). Patients with a valved conduit underwent more interventions for conduit obstruction in the interstage period, but this difference did not reach significance (P = .16). There were no differences between groups in echocardiographic parameters of right ventricle function at baseline or pre-Glenn. In this cohort of patients with hypoplastic left heart syndrome, inclusion of a valved right ventricle to pulmonary artery conduit was not associated with any difference in survival on adjusted analysis and did not confer an identifiable benefit on right ventricle function. Copyright © 2017 The American Association for Thoracic Surgery. Published by Elsevier

  10. Challenges of using electrical resistivity method to locate karst conduits-A field case in the Inner Bluegrass Region, Kentucky

    Science.gov (United States)

    Zhu, J.; Currens, J.C.; Dinger, J.S.

    2011-01-01

    Conduits serve as major pathways for groundwater flow in karst aquifers. Locating them from the surface, however, is one of the most challenging tasks in karst research. Geophysical methods are often deployed to help locate voids by mapping variations of physical properties of the subsurface. Conduits can cause significant contrasts of some physical properties that can be detected; other subsurface features such as water-bearing fractures often yield similar contrasts, which are difficult to distinguish from the effects of the conduits. This study used electrical resistivity method to search for an unmapped karst conduit that recharges Royal Spring in the Inner Bluegrass karst region, Kentucky, USA. Three types of resistivity techniques (surface 2D survey, quasi-3D survey, and time-lapse survey) were used to map and characterize resistivity anomalies. Some of the major anomalies were selected as drilling targets to verify the existence of the conduits. Drilling near an anomaly identified by an electrical resistivity profile resulted in successful penetration of a major water-filled conduit. The drilling results also suggest that, in this study area, low resistivity anomalies in general are associated with water-bearing features. However, differences in the anomaly signals between the water-filled conduit and other water-bearing features such as water-filled fracture zones were undistinguishable. The electrical resistivity method is useful in conduit detection by providing potential drilling targets. Knowledge of geology and hydrogeology about the site and professional judgment also played important roles in locating the major conduit. ?? 2011 Elsevier B.V.

  11. Criteria of validity in the measurement of shearing fracture toughness; Gueltigkeitskriterien zur Bestimmung von Scherbruchzaehigkeiten

    Energy Technology Data Exchange (ETDEWEB)

    Hiese, W

    2000-01-01

    The investigations aimed at the development of criteria for measuring valid shearing fracture toughness data K{sub IIc} in analogy to the measurement of mode-I fracture toughness K{sub Ie}. Details are presented, and practical recommendations are given. [German] Die Brucheigenschaften von Werkstoffen werden ueblicherweise unter Zugbeanspruchungsbedingungen (Mode-I) bestimmt. Im Anwendungsbereich der linear-elastischen Bruchmechanik bzw. des Kleinbereichsfliessens geschieht dieses in Form der Bruchzaehigkeit K{sub Ic}. Es existieren entsprechende Richtlinien zur Durchfuehrung des Tests sowie zur Registrierung und Auswertung der Daten. Diese Kriterien sind in Standards festgelegt. Empfehlungen zur Bestimmung der Bruchzaehigkeit K{sub IIc} unter ebener Scherbelastung (Mode-II) fuer Werkstoffe mit im wesentlichen linear-elastischem Verhalten existieren nicht. Im Rahmen dieser Arbeit werden durch den Vergleich der Groesse der plastischen Rissspitzenzonen im Verhaeltnis zu den Abmessungen von Probe bzw. Bauteil Kriterien zur Messung gueltiger Scherbruchzaehigkeiten K{sub IIc} analog zur Messung der Mode-I-Bruchzaehigkeit K{sub Ic} entwickelt. Der Groessenvergleich der plastischen Rissspitzenzonen fuer beide Beanspruchungsarten zeigt unter aequivalenten Beanspruchungen, d.h. K{sub II}=K{sub I}, dass bei Mode-II beanspruchten Rissen die plastischen Zonen groesser, aber die Differenzen in der Groesse der plastischen Zonen fuer die Zustaende ebener Spannung und ebener Dehnung kleiner sind als unter entsprechenden Mode-I-Beanspruchungen.

  12. Using MODFLOW with CFP to understand conduit-matrix exchange in a karst aquifer during flooding

    Science.gov (United States)

    Spellman, P.; Screaton, E.; Martin, J. B.; Gulley, J.; Brown, A.

    2011-12-01

    Karst springs may reverse flow when allogenic runoff increases river stage faster than groundwater heads and may exchange of surface water with groundwater in the surrounding aquifer matrix. Recharged flood water is rich in nutrients, metals, and organic matter and is undersaturated with respect to calcite. Understanding the physical processes controlling this exchange of water is critical to understanding metal cycling, redox chemistry and dissolution in the subsurface. Ultimately the magnitude of conduit-matrix exchange should be governed by head gradients between the conduit and the aquifer which are affected by the hydraulic conductivity of the matrix, conduit properties and antecedent groundwater heads. These parameters are interrelated and it is unknown which ones exert the greatest control over the magnitude of exchange. This study uses MODFLOW-2005 coupled with the Conduit Flow Processes (CFP) package to determine how physical properties of conduits and aquifers influence the magnitude of surface water-groundwater exchange. We use hydraulic data collected during spring reversals in a mapped underwater cave that sources Madison Blue Spring in north-central Florida to explore which factors are most important in governing exchange. The simulation focused on a major flood in 2009, when river stage increased by about 10 meters over 9 days. In a series of simulations, we varied hydraulic conductivity, conduit diameter, roughness height and tortuosity in addition to antecedent groundwater heads to estimate the relative effects of each parameter on the magnitude of conduit-matrix exchange. Each parameter was varied across plausible ranges for karst aquifers. Antecedent groundwater heads were varied using well data recorded through wet and dry seasons throughout the spring shed. We found hydraulic conductivity was the most important factor governing exchange. The volume of exchange increased by about 61% from the lowest value (1.8x10-6 m/d) to the highest value (6 m

  13. Lorentz force effect on mixed convection micropolar flow in a vertical conduit

    Science.gov (United States)

    Abdel-wahed, Mohamed S.

    2017-05-01

    The present work provides a simulation of control and filtration process of hydromagnetic blood flow with Hall current under the effect of heat source or sink through a vertical conduit (pipe). This work meets other engineering applications, such as nuclear reactors cooled during emergency shutdown, geophysical transport in electrically conducting and heat exchangers at low velocity conditions. The problem is modeled by a system of partial differential equations taking the effect of viscous dissipation, and these equations are simplified and solved analytically as a series solution using the Differential Transformation Method (DTM). The velocities and temperature profiles of the flow are plotted and discussed. Moreover, the conduit wall shear stress and heat flux are deduced and explained.

  14. Engineering based assessment for a shape design of a pediatric ePTFE pulmonary conduit valve.

    Science.gov (United States)

    Tsuboko, Yusuke; Shiraishi, Yasuyuki; Yamada, Akihiro; Yambe, Tomoyuki; Miura, Hidekazu; Mura, Seitaro; Yamagishi, Masaaki

    2016-08-01

    The authors examined the hemodynamic characteristics of expanded polytetrafluoroethylene (ePTFE) pulmonary valved conduits quantitatively by our originally developed pediatric pulmonary mechanical circulatory system, in order to suggest the optimal shape design. The system consisted of pneumatically driven right atrium and ventricle model, a pulmonary valve chamber, and elastic pulmonary compliance model with peripheral vascular resistance units, a venous reservoir. We employed two different types of ePTFE valve and evaluated the relationship between the leaflets motion and hemodynamic characteristics by using a high-speed video camera. As a result, we successfully reproduced hemodynamic simulations in our pediatric pulmonary mock system. We confirmed that the presence of bulging sinuses in the pulmonary valved conduit reduced the transvalvular energy loss and increased the valve opening area during systolic period. Our engineering-based in vitro analysis could be useful for proposing a shape design optimization of sophisticated pediatric ePTFE pulmonary valve.

  15. AC losses and stability on large cable-in-conduit superconductors

    Science.gov (United States)

    Bruzzone, Pierluigi

    1998-12-01

    The cable-in-conduit superconductors are preferred for applications where the AC losses and stability are a major concern, e.g., fusion magnets and SMES. A review of coupling currents loss results for both NbTi and Nb 3Sn cable-in-conduit conductors (CICC) is presented and the AC loss relevant features are listed, with special emphasis for the role of the interstrand resistance and strand coating. The transient stability approach for CICCs is discussed and the analytical models are quoted as well as the relevant experimental database. The likely spectrum of transient disturbance in CICC is reviewed and the need to account for interstrand current sharing in the design is outlined. Eventually a practical criterion for the interstrand resistance is proposed to link the stability and AC loss design.

  16. Electromagnetic nondestructive testing at high lift-off using a magnetic image conduit

    International Nuclear Information System (INIS)

    Lee, Jin Yi; Jun, Jong Woo; Kim, Jung Min; Le, Min Hhuy

    2013-01-01

    To protect sensors from the extreme environments, such as, heat, moisture, pollution and radiation, cracks must be inspected for; this can be done by measuring the distribution of magnetic fields at high lift-off through nondestructive electro-magnetic testing. However, as the intensity of an electro-magnetic field is inversely proportional to the square of the lift-off, it becomes increasingly difficult to effective inspect a crack as the lift-off increases. In this paper, a magnetic image conduit to minimize the intensity loss of an electro-magnetic field at high lift-off is proposed, and the effectiveness of a conduit for magnetic imaging is verified by means of both theoretical and experimental approaches.

  17. Ceramic fiber blanket wrap for fire protection of cable trays and conduits

    International Nuclear Information System (INIS)

    Chaille, C.E.; Reiman, R.J.

    1980-01-01

    In some areas of nuclear power plants, cables of redundant electrical systems, which are necessary for the safe shutdown of the reactor, are in close proximity. If a fire should occur in one of these areas, both electrical systems could be destroyed before the fire is extinguished and control of the reactor may be lost. A ceramic fiber blanket was evaluated as a fire protective wrap around cable trays and conduits. 2 refs

  18. Ileal-conduit following cystectomy, single-institution revision of indications and outcome

    International Nuclear Information System (INIS)

    Abol-Enein, Hassan A.; Abdul-Muhsin, Ausama S.; Alhallaq, Yousuf M.

    2008-01-01

    Objective was to revise indications, case fatality ratio, and postoperative early and late complications of ileal conduit as a method of urinary diversion. This is a retrospective study in which 200 patients underwent an ileal conduit from August 1994 to December 2000 in Mansoura Urology and Nephrology Center, Mansoura, Egypt. Preoperative criteria of patient selection, preoperative findings and postoperative follow-up data were reviewed. In 200 patients aged 29-75 years, with a mean age of 55.84-/+ 8.91 years, the ileal conduit was chosen as a method of urinary diversion, due to one of the following patient or surgical factors; 50 (25%) cardiopulmonary co-morbidities, 27(13.5%) liver cirrhosis, 20 (10%) impaired renal function, 18 (9%) poorly controlled diabetes mellitus and 3 (1.5%) morbid obesity. Frozen section pathological examination showed carcinoma invasion of the urethra in 26 (13%) and prostate stroma in 16 (8%) male patients. Severe adhesions and difficulty cystectomy were encountered in 25 (12.5%) patients. Tumor was found at or close to the bladder neck in 13 (6.5%) female patients and 2 (1%) patients were found to have short mesentery. The mean follow up period was 90.02 -/+ 22.63 months. Fatality rate was 2%. Twenty-three (11.5%) patients had early complications, while 36 (23.7%) patients had late complications. Ileal conduit is still the best urinary diversion method in many patients who have bladder cancer with associated chronic medical disease or certain surgical factors that render other urinary diversion methods more difficult carry more postoperative morbidity and mortality or both. (author)

  19. Development and fabrication of superconducting hybrid Cable-In-Conduit-Conductor (CICC) for indigenous fusion programme

    International Nuclear Information System (INIS)

    Singh, A.K.; Hussain, M.M.; Abdulla, K.K.; Singh, R.P.

    2011-01-01

    The Atomic Fuels Division has initiated development and fabrication of Cable-In-Conduit-Conductor (CICC) of various configurations, for superconducting fusion grade magnets required for their indigenous Fusion Programme. The process involves development of high grade superconducting multifilamentary wire, multi stage cabling of superconducting as well as copper wires and, finally, jacketing of the cables in SS316LN tubes. The overview of the development and fabrication of CICC is presented in this article. (author)

  20. Natural Occurring Silks and Their Analogues as Materials for Nerve Conduits

    OpenAIRE

    Christine Radtke

    2016-01-01

    Spider silk and its synthetic derivatives have a light weight in combination with good strength and elasticity. Their high cytocompatibility and low immunogenicity make them well suited for biomaterial products such as nerve conduits. Silk proteins slowly degrade enzymatically in vivo, thus allowing for an initial therapeutic effect such as in nerve scaffolding to facilitate endogenous repair processes, and then are removed. Silks are biopolymers naturally produced by many species of arthropo...

  1. Selective reinnervation: a comparison of recovery following microsuture and conduit nerve repair.

    Science.gov (United States)

    Evans, P J; Bain, J R; Mackinnon, S E; Makino, A P; Hunter, D A

    1991-09-20

    Selective reinnervation was studied by comparing the regeneration across a conventional neurorraphy versus a conduit nerve repair. Lewis rats underwent right sciatic nerve transection followed by one of four different nerve repairs (n = 8/group). In groups I and II a conventional neurorraphy was performed and in groups III and IV the proximal and distal stumps were coapted by use of a silicone conduit with an interstump gap of 5 mm. The proximal and distal stumps in groups I and III were aligned anatomically correct and the proximal stump was rotated 180 degrees in groups II and IV (i.e. proximal peroneal nerve opposite the distal tibial nerve and the proximal tibial nerve opposite the distal peroneal nerve). By 14 weeks, there was an equivalent, but incomplete return in sciatic function index (SFI) in groups I, III, and IV as measured by walking track analysis. However, the SFI became unmeasurable by 6 weeks in all group II animals. At 14 weeks, the percent innervation of the tibialis anterior and medial gastronemius muscles by the peroneal and tibial nerves respectively was estimated by selective compound muscle action potential amplitude recordings. When fascicular alignment was reversed, there was greater tibial (P = 0.02) and lesser peroneal (P = 0.005) innervation of the gastrocnemius muscle in the conduit (group IV) versus the neurorraphy (group II) group. This suggests that the gastrocnemius muscle may be selectively reinnervated by the tibial nerve. However, there was no evidence of selective reinnervation of the tibialis anterior muscle. Despite these differences, the functional recovery in both conduit repair groups (III and IV) was equivalent to a correctly aligned microsuture repair (group I) and superior to that in the incorrectly aligned microsuture repair (group II).

  2. Bronchovascular reconstruction with a bovine pericardial conduit and surgical reintervention due to thrombosis with revascularisation.

    Science.gov (United States)

    Peña, Emilio; Blanco, Montserrat; Otero, Teresa

    2014-01-01

    We present the case of a 57-year-old male with left hilar squamous cell carcinoma infiltrating the pulmonary artery and in whom a sleeve bronchoplasty and angioplasty were performed using a bovine pericardial conduit. Three days post-operatively, graft thrombosis was detected; thrombectomy and graft reconstruction were performed with revascularisation of the graft. Copyright © 2013 SEPAR. Published by Elsevier Espana. All rights reserved.

  3. Adult Stem Cell Based Enhancement of Nerve Conduit for Peripheral Nerve Repair

    Science.gov (United States)

    2016-10-01

    accompanied by injuries to peripheral nerves; if not repaired, the trauma can lead to significant dysfunction and disability . While nerves have the ability to...recovery, minimized disability , and increased quality of life for our wounded warriors. 2. KEYWORDS: Stem Cell, Nerve Conduit, Peripheral Nerve...would be a paradigm shift away from ordering X-rays at 10-12 weeks and only ordering a CT scan. It has the potential to change the standard of care

  4. Innovations for vehicle weight savings; Innovationen zur Gewichtseinsparung bei Kraftfahrzeugen

    Energy Technology Data Exchange (ETDEWEB)

    Phillips, W.C. [Budd Technical Center, Auburn Hills, MI (United States)

    1999-04-01

    The American auto market provides an example of the conflict between government legislation calling for fuel economy and lower emissions, which can be achieved among other things by reducing vehicle weight, and other legislative initiatives on the safety front as well as the growing demands of consumers for comfort, which add weight to the vehicle. Automakers are responding by making increasing use of lightweight materials and weight-optimized vehicle concepts. Backed by years of experience with a variety of materials, The Budd Company - an American subsidiary of the Thyssen-Krupp Group - is in an excellent position to offer customized lightweight systems solutions. From conventional steel to high-strength steels, aluminum castings, sheet and extrusions through to high-quality plastics such as SMC and SRIM, lightweight solutions for auto bodies and chassis are developed and offered to the automotive industry. The lightweighting potential of these various materials is being further exploited through the use of advanced manufacturing processes, such as the hydroforming of steel and aluminum, tailored blanks made of steel, and bonding techniques for aluminum. (orig.) [German] Das Beispiel des amerikanischen Automobilmarktes zeigt die entgegengesetzten Forderungen des Gesetzgebers zur Kraftstoff- und Emissionsreduzierung, was u.a. durch eine Verringerung des Fahrzeuggewichtes zu erreichen ist, und Gesetzesinitiativen im Bereich der Fahrzeugsicherheit sowie wachsende Komfort-Ansprueche der Kunden, die zur Gewichtserhoehung fuehren, auf. Die Fahrzeughersteller reagieren hierauf mit zunehmendem Einsatz leichter Werkstoffe und gewichtsoptimierter Leichtbau-Konzepte. Im Verbund des ThyssenKrupp Konzerns ist das amerikanische Tochterunternehmen The Budd Company aufgrund ihrer jahrelangen Erfahrungen mit einer Vielzahl von Werkstoffen in der herausragenden Position, individuelle und den jeweiligen Anforderungen entsprechende Leichtbau-Systemloesungen anbieten zu koennen. Vom

  5. Long distance seawater intrusion through a karst conduit network in the Woodville Karst Plain, Florida

    Science.gov (United States)

    Xu, Zexuan; Bassett, Seth Willis; Hu, Bill; Dyer, Scott Barrett

    2016-08-01

    Five periods of increased electrical conductivity have been found in the karst conduits supplying one of the largest first magnitude springs in Florida with water. Numerous well-developed conduit networks are distributed in the Woodville Karst Plain (WKP), Florida and connected to the Gulf of Mexico. A composite analysis of precipitation and electrical conductivity data provides strong evidence that the increases in conductivity are directly tied to seawater intrusion moving inland and traveling 11 miles against the prevailing regional hydraulic gradient from from Spring Creek Spring Complex (SCSC), a group of submarine springs at the Gulf Coast. A geochemical analysis of samples from the spring vent rules out anthropogenic contamination and upwelling regional recharge from the deep aquifer as sources of the rising conductivity. The interpretation is supported by the conceptual model established by prior researchers working to characterize the study area. This paper documents the first and longest case of seawater intrusion in the WKP, and also indicates significant possibility of seawater contamination through subsurface conduit networks in a coastal karst aquifer.

  6. Analysis of aortic root surgery with composite mechanical aortic valve conduit and valve-sparing reconstruction.

    Science.gov (United States)

    Dias, Ricardo Ribeiro; Mejia, Omar Asdrubal Vilca; Fiorelli, Alfredo Inácio; Pomerantzeff, Pablo Maria Alberto; Dias, Altamiro Ribeiro; Mady, Charles; Stolf, Noedir Antonio Groppo

    2010-01-01

    Comparative analysis of early and late results of aortic root reconstruction with aortic valve sparing operations and the composite mechanical valve conduit replacement. From November 2002 to September 2009, 164 consecutive patients with mean age 54 ± 15 years, 115 male, underwent the aortic root reconstruction (125 mechanical valve conduit replacements and 39 valve sparing operations). Sixteen percent of patients had Marfan syndrome and 4.3% had bicuspid aortic valve. One hundred and forty-four patients (88%) were followed for a mean period of 41.1 ± 20.8 months. The hospital mortality was 4.9%, 5.6% in operations with valved conduits and 2.6% in the valve sparing procedures (P valve sparing operations, respectively (95% CI = 70% - 95%, P = 0.001), (95% CI = 82% - 95% P = 0.03) and (95% CI = 81% - 95%, P = 0.03). Multivariate analysis showed that creatinine greater than 1.4 mg/dl, Cabrol operation and renal dialysis were predictors of mortality, respectively, with occurrence chance of 6 (95% CI = 1.8 - 19.5, P = 0.003), 12 (95% CI = 3 - 49.7, P = 0.0004) and 16 (95% CI = 3.6 - 71.3, P = 0.0002). The aortic root reconstruction has a low early and late mortality, high survival free of complications and low need for reoperation. During the late follow-up, valve sparing aortic root reconstructions presented fewer incidences of bleeding, thromboembolic events and endocarditis.

  7. Analytical studies on hotspot temperature of cable-in-conduit conductors

    International Nuclear Information System (INIS)

    Yoshida, Kiyoshi; Takigami, Hiroyoshi; Kubo, Hiroatsu

    2001-01-01

    This paper describes an analytical study to review the hotspot temperature design criteria of the cable-in-conduit conductors for the ITER magnet system. The ITER magnet system uses three kinds of cable-in-conduit conductors for the Toroidal Field (TF) coils, the Central Solenoid (CS) and the Poloidal Field (PF) coils. The amount of copper in the superconducting cable has been defined by using the classical hotspot temperature design criteria that is based on the adiabatic condition. In the current design, ITER superconducting cables include a large amount of pure copper strands to satisfy the classical criteria. However, temperature and stress in the conduit and insulations after quench can be simulated with the quench simulation program and stress analysis program using the latest analysis tools. This analysis shows that the strand temperature is dominated by the conduction along strands and the heat capacity of other conductor materials and coolant. The hotspot temperature depends strongly on the delay time for quench detection. This analysis provides an estimation of delay times for quench detection. The thermal and stress analysis can provide the maximum allowable temperature after quench by determination of a failure or a functional disorder condition of the jacket material and turn insulation. In conclusion, it is found that the current density of the cable space can be increased, by reducing the extra copper strand, thereby, allowing a reduction of the coil radial build. (author)

  8. The Norwood procedure: in favor of the RV-PA conduit.

    Science.gov (United States)

    Barron, David J

    2013-01-01

    Evolution of the Norwood procedure has culminated in there currently being three treatment strategies available for initial management: the 'classical' Norwood (utilizing a Blalock-Taussig shunt), the Norwood with right-ventricle to pulmonary artery (RV-PA) conduit, and the 'hybrid' Norwood procedure utilizing bilateral pulmonary artery banding and ductal stenting. Each variant has its potential advantages and disadvantages, and this paper looks to examine the evidence in favor of each strategy, with emphasis on the supportive data for the RV-PA conduit. The 'classical' procedure has the benefit of the greatest accumulated surgical experience and avoids any incision into the ventricle. However, the diastolic run-off of the Blalock-Taussig shunt can cause hemodynamic instability and unpredictable coronary steal phenomenon. The RV-PA conduit has the advantage of maintaining diastolic pressure with a more stable postoperative course, but at the cost of a ventriculotomy that may have detrimental long-term sequelae. The 'hybrid' procedure has the advantage of avoiding cardiopulmonary bypass, but does not always secure coronary blood flow and has a high inter-stage morbidity and reintervention rate. The evidence shows that each technique may have its place in future management, and that treatment algorithms could emerge that direct the choice of procedure for specific patient groups. Copyright © 2013 Elsevier Inc. All rights reserved.

  9. Natural Occurring Silks and Their Analogues as Materials for Nerve Conduits

    Directory of Open Access Journals (Sweden)

    Christine Radtke

    2016-10-01

    Full Text Available Spider silk and its synthetic derivatives have a light weight in combination with good strength and elasticity. Their high cytocompatibility and low immunogenicity make them well suited for biomaterial products such as nerve conduits. Silk proteins slowly degrade enzymatically in vivo, thus allowing for an initial therapeutic effect such as in nerve scaffolding to facilitate endogenous repair processes, and then are removed. Silks are biopolymers naturally produced by many species of arthropods including spiders, caterpillars and mites. The silk fibers are secreted by the labial gland of the larvae of some orders of Holometabola (insects with pupa or the spinnerets of spiders. The majority of studies using silks for biomedical applications use materials from silkworms or spiders, mostly of the genus Nephila clavipes. Silk is one of the most promising biomaterials with effects not only in nerve regeneration, but in a number of regenerative applications. The development of silks for human biomedical applications is of high scientific and clinical interest. Biomaterials in use for biomedical applications have to meet a number of requirements such as biocompatibility and elicitation of no more than a minor inflammatory response, biodegradability in a reasonable time and specific structural properties. Here we present the current status in the field of silk-based conduit development for nerve repair and discuss current advances with regard to potential clinical transfer of an implantable nerve conduit for enhancement of nerve regeneration.

  10. Cardiovascular effects of right ventricle-pulmonary artery valved conduit implantation in experimental pulmonic stenosis

    International Nuclear Information System (INIS)

    Saida, Y.; Tanaka, R.; Fukushima, R.; Hoshi, K.; Hira, S.; Soda, A.; Iizuka, T.; Ishikawa, T.; Nishimura, T.; Yamane, Y.

    2009-01-01

    Right ventricle (RV)-pulmonary artery (PA) valved conduit (RPVC) implantation decreases RV systolic pressure in pulmonic stenosis (PS) by forming a bypass route between the RV and the PA. The present study evaluates valved conduits derived from canine aortae in a canine model of PS produced by pulmonary artery banding (PAB). Pulmonary stenosis was elicited using PAB in 10 conditioned beagles aged 8 months. Twelve weeks after PAB, the dogs were assigned to one group that did not undergo surgical intervention and another that underwent RPVC using denacol-treated canine aortic valved grafts (PAB+RPVC). Twelve weeks later, the rate of change in the RV-PA systolic pressure gradient was significantly decreased in the PAB+RPVC, compared with the PAB group (60.5+-16.7% vs. 108.9+-22.9%; p0.01). In addition, the end-diastolic RV free wall thickness (RVFWd) was significantly reduced in the PAB+RPVC, compared with the PAB group (8.2+-0.2 vs. 9.4+-0.7 mm; p0.05). Thereafter, regurgitation was not evident beyond the conduit valve and the decrease in RV pressure overload induced by RPVC was confirmed. The present results indicate that RPVC can be performed under a beating heart without cardiopulmonary bypass and adapted to dogs with various types of PS, including 'supra valvular' PS or PS accompanied by dysplasia of the pulmonary valve. Therefore, we consider that this method is useful for treating PS in small animals

  11. Continent catheterizable conduit for urinary diversion in children: Applicability and acceptability

    Directory of Open Access Journals (Sweden)

    Shailesh Solanki

    2015-01-01

    Full Text Available Background: Continent catheterizable conduit (CCC has made clean intermittent catheterization (CIC painless and easy. It is applicable in diverse clinical conditions. Nonetheless, convincing the parents for the need of conduit procedure is still difficult. Materials and Methods: A prospective study, included children who underwent CCC procedure from March 2008 to February 2013. The data were assessed for; diagnosis, type of conduit, number of preoperative counselling sessions before acceptance, role of "self-help group" in decision making, parental concern and satisfaction for the procedure. Results: Twenty-nine patients (males; 24, females; 5 underwent CCC procedure for various clinical conditions. The multiple preoperative counselling sessions and creation of "self-help groups" were helped them for decision making. The main concerns among parents were: (1 Impact of procedure on future fertility and sexual life. (2 Patency of native urethral channel. (3 Permanent urinary stoma over the abdomen. Conclusion: CCC procedures are applicable to a wide array of clinical situations with a good outcome. The acceptability of the CCC procedure improves with preoperative counselling of parent/child, initiation of preoperative per urethral CIC and creation of self-help groups.

  12. Influence of conduit flow mechanics on magma rheology and the growth style of lava domes

    Science.gov (United States)

    Husain, Taha; Elsworth, Derek; Voight, Barry; Mattioli, Glen; Jansma, Pamela

    2018-06-01

    We develop a 2-D particle-mechanics model to explore different lava-dome growth styles. These range from endogenous lava dome growth comprising expansion of a ductile dome core to the exogenous extrusion of a degassed lava plug resulting in generation of a lava spine. We couple conduit flow dynamics with surface growth of the evolving lava dome, fuelled by an open-system magma chamber undergoing continuous replenishment. The conduit flow model accounts for the variation in rheology of ascending magma that results from degassing-induced crystallization. A period of reduced effusive flow rates promote enhanced degassing-induced crystallization. A degassed lava plug extrudes exogenously for magmas with crystal contents (ϕ) of 78 per cent, yield strength >1.62 MPa, and at flow rates of 3 m3 s-1) for magma with lower relative yield strengths (p = 3 MPa) at the conduit exit is forced out by the high discharge rate pulse (2 process, which has been observed at Mount St. Helens and other locations, largely reflects gravitational loading of dome with a viscous core, with retardation by yield strength and talus friction.

  13. Application of near real-time radial semblance to locate the shallow magmatic conduit at Kilauea Volcano, Hawaii

    Science.gov (United States)

    Dawson, P.; Whilldin, D.; Chouet, B.

    2004-01-01

    Radial Semblance is applied to broadband seismic network data to provide source locations of Very-Long-Period (VLP) seismic energy in near real time. With an efficient algorithm and adequate network coverage, accurate source locations of VLP energy are derived to quickly locate the shallow magmatic conduit system at Kilauea Volcano, Hawaii. During a restart in magma flow following a brief pause in the current eruption, the shallow magmatic conduit is pressurized, resulting in elastic radiation from various parts of the conduit system. A steeply dipping distribution of VLP hypocenters outlines a region extending from sea level to about 550 m elevation below and just east of the Halemaumau Pit Crater. The distinct hypocenters suggest the shallow plumbing system beneath Halemaumau consists of a complex plexus of sills and dikes. An unconstrained location for a section of the conduit is also observed beneath the region between Kilauea Caldera and Kilauea Iki Crater.

  14. Sciatic nerve regeneration in rats by a promising electrospun collagen/poly(ε-caprolactone nerve conduit with tailored degradation rate

    Directory of Open Access Journals (Sweden)

    Jiang Xinquan

    2011-07-01

    Full Text Available Abstract Background To cope with the limitations faced by autograft acquisitions particularly for multiple nerve injuries, artificial nerve conduit has been introduced by researchers as a substitute for autologous nerve graft for the easy specification and availability for mass production. In order to best mimic the structures and components of autologous nerve, great efforts have been made to improve the designation of nerve conduits either from materials or fabrication techniques. Electrospinning is an easy and versatile technique that has recently been used to fabricate fibrous tissue-engineered scaffolds which have great similarity to the extracellular matrix on fiber structure. Results In this study we fabricated a collagen/poly(ε-caprolactone (collagen/PCL fibrous scaffold by electrospinning and explored its application as nerve guide substrate or conduit in vitro and in vivo. Material characterizations showed this electrospun composite material which was made of submicron fibers possessed good hydrophilicity and flexibility. In vitro study indicated electrospun collagen/PCL fibrous meshes promoted Schwann cell adhesion, elongation and proliferation. In vivo test showed electrospun collagen/PCL porous nerve conduits successfully supported nerve regeneration through an 8 mm sciatic nerve gap in adult rats, achieving similar electrophysiological and muscle reinnervation results as autografts. Although regenerated nerve fibers were still in a pre-mature stage 4 months postoperatively, the implanted collagen/PCL nerve conduits facilitated more axons regenerating through the conduit lumen and gradually degraded which well matched the nerve regeneration rate. Conclusions All the results demonstrated this collagen/PCL nerve conduit with tailored degradation rate fabricated by electrospinning could be an efficient alternative to autograft for peripheral nerve regeneration research. Due to its advantage of high surface area for cell attachment, it

  15. Polyurethane/Gelatin Nanofibrils Neural Guidance Conduit Containing Platelet-Rich Plasma and Melatonin for Transplantation of Schwann Cells.

    Science.gov (United States)

    Salehi, Majid; Naseri-Nosar, Mahdi; Ebrahimi-Barough, Somayeh; Nourani, Mohammdreza; Khojasteh, Arash; Farzamfar, Saeed; Mansouri, Korosh; Ai, Jafar

    2018-04-01

    The current study aimed to enhance the efficacy of peripheral nerve regeneration using a biodegradable porous neural guidance conduit as a carrier to transplant allogeneic Schwann cells (SCs). The conduit was prepared from polyurethane (PU) and gelatin nanofibrils (GNFs) using thermally induced phase separation technique and filled with melatonin (MLT) and platelet-rich plasma (PRP). The prepared conduit had the porosity of 87.17 ± 1.89%, the contact angle of 78.17 ± 5.30° and the ultimate tensile strength and Young's modulus of 5.40 ± 0.98 MPa and 3.13 ± 0.65 GPa, respectively. The conduit lost about 14% of its weight after 60 days in distilled water. The produced conduit enhanced the proliferation of SCs demonstrated by a tetrazolium salt-based assay. For functional analysis, the conduit was seeded with 1.50 × 10 4 SCs (PU/GNFs/PRP/MLT/SCs) and implanted into a 10-mm sciatic nerve defect of Wistar rat. Three control groups were used: (1) PU/GNFs/SCs, (2) PU/GNFs/PRP/SCs, and (3) Autograft. The results of sciatic functional index, hot plate latency, compound muscle action potential amplitude and latency, weight-loss percentage of wet gastrocnemius muscle and histopathological examination using hematoxylin-eosin and Luxol fast blue staining, demonstrated that using the PU/GNFs/PRP/MLT conduit to transplant SCs to the sciatic nerve defect resulted in a higher regenerative outcome than the PU/GNFs and PU/GNFs/PRP conduits.

  16. Incorporation of cooling-induced crystallization into a 2-dimensional axisymmetric conduit heat flow model

    Science.gov (United States)

    Heptinstall, David; Bouvet de Maisonneuve, Caroline; Neuberg, Jurgen; Taisne, Benoit; Collinson, Amy

    2016-04-01

    Heat flow models can bring new insights into the thermal and rheological evolution of volcanic 3 systems. We shall investigate the thermal processes and timescales in a crystallizing, static 4 magma column, with a heat flow model of Soufriere Hills Volcano (SHV), Montserrat. The latent heat of crystallization is initially computed with MELTS, as a function of pressure and temperature for an andesitic melt (SHV groundmass starting composition). Three fractional crystallization simulations are performed; two with initial pressures of 34MPa (runs 1 & 2) and one of 25MPa (run 3). Decompression rate was varied between 0.1MPa/° C (runs 1 & 3) and 0.2MPa/° C (run 2). Natural and experimental matrix glass compositions are accurately reproduced by all MELTS runs. The cumulative latent heat released for runs 1, 2 and 3 differs by less than 9% (8.69E5 J/kg*K, 9.32E5 J/kg*K, and 9.49E5 J/kg*K respectively). The 2D axisymmetric conductive cooling simulations consider a 30m-diameter conduit that extends from the surface to a depth of 1500m (34MPa). The temporal evolution of temperature is closely tracked at depths of 10m, 750m and 1400m in the centre of the conduit, at the conduit walls, and 20m from the walls into the host rock. Following initial cooling by 7-15oC at 10m depth inside the conduit, the magma temperature rebounds through latent heat release by 32-35oC over 85-123 days to a maximum temperature of 1002-1005oC. At 10m depth, it takes 4.1-9.2 years for the magma column to cool by 108-131oC and crystallize to 75wt%, at which point it cannot be easily remobilized. It takes 11-31.5 years to reach the same crystallinity at 750-1400m depth. We find a wide range in cooling timescales, particularly at depths of 750m or greater, attributed to the initial run pressure and the dominant latent heat producing crystallizing phase, Albite-rich Plagioclase Feldspar. Run 1 is shown to cool fastest and run 3 cool the slowest, with surface emissivity having the strongest cooling

  17. On magma fragmentation by conduit shear stress: Evidence from the Kos Plateau Tuff, Aegean Volcanic Arc

    Science.gov (United States)

    Palladino, Danilo M.; Simei, Silvia; Kyriakopoulos, Konstantinos

    2008-12-01

    Large silicic explosive eruptions are the most catastrophic volcanic events. Yet, the intratelluric mechanisms underlying are not fully understood. Here we report a field and laboratory study of the Kos Plateau Tuff (KPT, 161 ka, Aegean Volcanic Arc), which provides an excellent geological example of conduit processes that control magma vesiculation and fragmentation during intermediate- to large-scale caldera-forming eruptions. A prominent feature of the KPT is the occurrence of quite unusual platy-shaped tube pumice clasts in pyroclastic fall and current deposits from the early eruption phases preceding caldera collapse. On macroscopic and SEM observations, flat clast faces are elongated parallel to tube vesicles, while transverse surfaces often occur at ~ 45° to vesicle elongation. This peculiar pumice texture provides evidence of high shear stresses related to strong velocity gradients normal to conduit walls, which induced vesiculation and fragmentation of the ascending magma. Either an increasing mass discharge rate without adequate enlargement of a narrow central feeder conduit or a developing fissure-like feeder system related to incipient caldera collapse provided suitable conditions for the generation of plate tube pumice within magma volumes under high shear during the pre-climactic KPT eruption phases. This mechanism implies that the closer to the conduit walls (where the stronger are the velocity gradients) the larger was the proportion of plate vs. conventional (lensoid) juvenile fragments in the ascending gas-pyroclast mixture. Consequently, plate pumice clasts were mainly entrained in the outer portions of the jet and convecting regions of a sustained, Plinian-type, eruption column, as well as in occasional lateral blast currents generated at the vent. As a whole, plate pumice clasts in the peripheral portions of the column were transported at lower altitudes and deposited by fallout or partial collapse closer to the vent relative to lensoid ones

  18. Beiträge zur indogermanischen wortforschung IV

    Directory of Open Access Journals (Sweden)

    Bojan Čop

    1958-12-01

    Full Text Available »Hoffnung«, pahl. umēt bzw. ōmēt soll nach Horn, Grdr. d. npers. Etym. 26 aus ava (Präp. und dem Yerbum may- »einsenken« zusammengesetzt sein, was leider aus bedeutungsgeschichtlichen Gründen unannehmbar ist. Hübschmann, Pers. St. 17 f. erklärt das Wort für vollkommen dunkel. Die uriran. Form *ava-maiti- (Hübschmann kann nicht auf eine Zusammensetzung mit *mn-ti- »Denken, Gedanke« = ai. mati-š, aw. -maitiš zurückgehen, da eine i-Epenthese hier völlig unmöglich wäre. Man muß *-mai-ti- analysieren, es ergibt sich also eine Wurzel *mai-, idg. entweder mei dann Vollstufe in dem /i-Abstraktum wie in ai. man-ti- »Denken«, got. ana-minds »Verdacht« — oder eventuell *mēi-.

  19. Investigations on passive containment cooling; Untersuchungen zur passiven Containmentkuehlung

    Energy Technology Data Exchange (ETDEWEB)

    Knebel, J.U.; Cheng, X.; Neitzel, H.J.; Erbacher, F.J. [Forschungszentrum Karlsruhe GmbH Technik und Umwelt (Germany). Inst. fuer Angewandte Thermo- und Fluiddynamik; Hofmann, F. [Forschungszentrum Karlsruhe GmbH Technik und Umwelt (Germany). Projekt Nukleare Sicherheitsforschung

    1997-12-31

    The composite containment design for advanced LWRs that has been examined under the PASCO project is a promising design concept for purely passive decay heat removal after a severe accident. The passive cooling processes applied are natural convection and radiative heat transfer. Heat transfer through the latter process removes at an emission coefficient of 0.9 about 50% of the total heat removed via the steel containment, and thus is an essential factor. The heat transferring surfaces must have a high emission coefficient. The sump cooling concept examined under the SUCO project achieves a steady, natural convection-driven flow from the heat source to the heat sink. (orig./CB) [Deutsch] Das im PASCO Programm untersuchte Verbundcontainment fuer zukuenftige Leichtwasserreaktoren ist ein erfolgversprechendes rein passives System zur Nachwaermeabfuhr nach einem schweren Stoerfall. Die passiven Mechanismen der Waermeuebertragung sind Naturkonvektion und Waermestrahlung. Die durch Waermestrahlung uebertragene Waerme betraegt fuer einen Emissionskoeffizienten von 0.9 etwa 50% der insgesamt ueber das Stahl-Containment abgefuehrten Waerme und ist somit von entscheidender Bedeutung fuer die Nachwaermeabfuhr. Fuer die waermeuebertragenden Oberflaechen ist ein hoher Emissionkoeffizient erforderlich. Das im SUCO Programm untersuchte Sumpfkuehlkonzept realisiert eine stabile Naturkonvektionsstroemung zwischen Waermequelle und Waermesenke. (orig./DG)

  20. Optimum control strategy for phosphate elimination; Optimale Steuerstrategie zur Phosphatelimination

    Energy Technology Data Exchange (ETDEWEB)

    Heinrich, D.

    1997-12-31

    This study describes the most common phosphate elimination techniques. In the simplest cases, the chemicals are dosed according to previously established time curves. Nowadays, by contrast, dosage in proportion to quantity is largely preferred. Freight-proportional dosage will be more frequently employed in the future at plants for a population of more than 10000. Since investigations revealed that the results obtained using control systems are inferior to those obtained by means of automatic control systems, the latter are increasingly used. Even if PID control devices perform best, overshoot is not to be avoided with certainty because of the long dead time. According to the current state of knowledge, matched control and automatic control systems yield the best results. Further optimization can be achieved by driving them via a fuzzy-based system. (orig.) [Deutsch] In der vorliegenden Ausarbeitung wurden die gebraeuchlichsten Verfahren zur Phosphatelimination vorgestellt. In einfachsten Faellen wird die Dosierung nach festen Ganglinien vorgenommen. Sie wird heute weitgehend durch eine mengenproportionale Dosierung ersetzt. Frachtproportionale Dosierungen sind fuer Anlagen ueber 10.000 EW in Zukunft haeufiger zu finden. Nachdem die Untersuchungen gezeigt haben, dass Steuerungen nicht so gute Ergebnisse wie Reglungen ergaben, finden diese verstaerkt Anwendung. Auch wenn PID Regler das beste Ergebnis bringen, so kann mit Ihen wegen der langen Totzeiten ein Ueberschwingen nicht sicher vermieden werden. Nach heutiger Kenntnis erbringen aufeinander abgestimmte Steuer- und Reglungen die besten Ergebnisse. Werden sie ueber ein fuzzybasiertes System angesteuert, so ist eine weitere Optimierung gegeben. (orig.)

  1. Verbesserte Visualisierung der Koronararterien in MSCT-Daten mit direkter Vergleichbarkeit zur Angiographie

    Science.gov (United States)

    Lacalli, Christina; Jähne, Marion; Wesarg, Stefan

    In diesem Beitrag stellen wir neue, automatisierte Verfahren zur Visualisierung der Koronararterien einerseits und für eine direkte Vergleichbarkeit mit konventionellen Angiogrammen andererseits vor. Unser Ansatz umfasst Methoden für die automatische Extraktion des Herzens aus kontrastverstärkten CT-Daten, sowie für die Maskierung grosser kontrastmittelgefüllter Kavitäten des Herzens, um die Sichtbarkeit der Koronararterien bei der Darstellung mittels Volumenrendering zu verbessern. Zum direkten Vergleich mit konventionellen Angiographien wurde ein Verfahren zur automatischen Generierung von Projektionsansichten aus den CT-Daten entwickelt.

  2. Method for assessing modular concepts for reformate gas processing for PEM fuel cell systems for decentral power supply; Methodik zur Bewertung modularer Konzepte zur Reformatgasaufbereitung fuer PEM-Brennstoffzellenanlagen zur dezentralen Energieversorgung

    Energy Technology Data Exchange (ETDEWEB)

    Gerber, J.

    2007-02-08

    The dissertation presents the fundamentals of hydrogen gas processing and CO gas purification methods and, on this basis, develops a method for energetic modularisation of the gas treatment process. All process stages are modelled and analyzed on the basis of mass and energy balances. The theoretical discussion of solution methods for the balance equations of the various process stages is limited to the steam reforming and CO gas purification system. Parameters are defined for energetic assessment of the process variants. The method leads to the identification of energetically optimized process variants. Its main goal is the optimum utilisation of process-internal energy and mass flows. The graphic pinch method is a key component of the method presented; it is adapted to the exemplary process. [German] In der Dissertation wird, ausgehend von der Darstellung der Grundlagen der Wasserstoffgasaufbereitungs- und CO-Gasreinigungsverfahren, eine Methodik zur energetischen Modularisierung des Gasaufbereitungsprozesses entwickelt. Die Modellierung und Analyse der einzelnen Prozessstufen erfolgt auf der Basis von Masse- und Energiebilanzen. Die theoretische Darstellung der Loesungsmethoden fuer die Bilanzgleichungen der einzelnen Prozessstufen ist dabei auf das System Dampfreformierung und CO-Gasreinigung eingegrenzt. Parameter zur energetischen Bewertung der Prozessvarianten werden definiert. Die Methodik fuehrt zur Eingrenzung energetisch optimierter Prozessvarianten. Ihr Hauptziel liegt in der optimalen Nutzung prozessinterner Energie- und Stoffstroeme. Ein zentraler Bestandteil der Methodik ist die graphische Pinch-Methode. Sie wird dem vorliegenden Prozess angepasst.

  3. Delineating saturated conduit patterns and dimensions in the upper Floridan aquifer through numerical groundwater flow modeling (Invited)

    Science.gov (United States)

    Kincaid, T. R.; Meyer, B. A.

    2009-12-01

    In groundwater flow modeling, aquifer permeability is typically defined through model calibration. Since the pattern and size of conduits are part of a karstic permeability framework, those parameters should be constrainable through the same process given a sufficient density of measured conditions. H2H Associates has completed a dual-permeability steady-state model of groundwater flow through the western Santa Fe River Basin, Florida from which a 380.9 km network of saturated conduits was delineated through model calibration to heads and spring discharges. Two calibration datasets were compiled describing average high-water and average low-water conditions based on heads at 145 wells and discharge from 18 springs for the high-water scenario and heads at 188 wells and discharge from 9 springs for the low-water scenario. An initial conduit network was defined by assigning paths along mapped conduits and inferring paths along potentiometric troughs between springs and swallets that had been connected by groundwater tracing. These initial conduit assignments accounted for only 13.75 and 34.1 km of the final conduit network respectively. The model was setup using FEFLOW™ where conduits were described as discrete features embedded in a porous matrix. Flow in the conduits was described by the Manning-Strickler equation where variables for conduit area and roughness were used to adjust the volume and velocity of spring flows. Matrix flow was described by Darcy’s law where hydraulic conductivity variations were limited to three geologically defined internally homogeneous zones that ranged from ~2E-6 m/s to ~4E-3 m/s. Recharge for both the high-water and low-water periods was determined through a water budget analysis where variations were restricted to nine zones defined by land-use. All remaining variations in observed head were then assumed to be due to conduits. The model was iteratively calibrated to the high-water and low-water datasets wherein the location, size

  4. Pflicht zur Prüfung der Existenz des Internen Kontrollsystems: Bestandesaufnahme zur Steuerung und Kontrolle mittelgrosser Unternehmen in der Schweiz

    OpenAIRE

    Ruud, T F; Isufi, S; Friebe, P

    2008-01-01

    Die Pflicht zur Prüfung der Existenz des internen Kontrollsystems betrifft auch etliche mittelgrosse Unternehmen. Im Rahmen einer Umfrage haben das Institut für Rechnungswesen und Controlling der Universität Zürich und PricewaterhouseCoopers bei diesen Unternehmen eine Bestandesaufnahme zu Kontroll- und Prüfungsaktivitäten durchgeführt. Nachstehend werden die Ergebnisse der Umfrage zum internen Kontrollsystem präsentiert.

  5. Numerical modeling and sensitivity analysis of seawater intrusion in a dual-permeability coastal karst aquifer with conduit networks

    Directory of Open Access Journals (Sweden)

    Z. Xu

    2018-01-01

    Full Text Available Long-distance seawater intrusion has been widely observed through the subsurface conduit system in coastal karst aquifers as a source of groundwater contaminant. In this study, seawater intrusion in a dual-permeability karst aquifer with conduit networks is studied by the two-dimensional density-dependent flow and transport SEAWAT model. Local and global sensitivity analyses are used to evaluate the impacts of boundary conditions and hydrological characteristics on modeling seawater intrusion in a karst aquifer, including hydraulic conductivity, effective porosity, specific storage, and dispersivity of the conduit network and of the porous medium. The local sensitivity analysis evaluates the parameters' sensitivities for modeling seawater intrusion, specifically in the Woodville Karst Plain (WKP. A more comprehensive interpretation of parameter sensitivities, including the nonlinear relationship between simulations and parameters, and/or parameter interactions, is addressed in the global sensitivity analysis. The conduit parameters and boundary conditions are important to the simulations in the porous medium because of the dynamical exchanges between the two systems. The sensitivity study indicates that salinity and head simulations in the karst features, such as the conduit system and submarine springs, are critical for understanding seawater intrusion in a coastal karst aquifer. The evaluation of hydraulic conductivity sensitivity in the continuum SEAWAT model may be biased since the conduit flow velocity is not accurately calculated by Darcy's equation as a function of head difference and hydraulic conductivity. In addition, dispersivity is no longer an important parameter in an advection-dominated karst aquifer with a conduit system, compared to the sensitivity results in a porous medium aquifer. In the end, the extents of seawater intrusion are quantitatively evaluated and measured under different scenarios with the variabilities of

  6. Impact of pacing modality and biventricular pacing on cardiac output and coronary conduit flow in the post-cardiotomy patient.

    LENUS (Irish Health Repository)

    Healy, David G

    2012-02-03

    We have previously demonstrated the role of univentricular pacing modalities in influencing coronary conduit flow in the immediate post-operative period in the cardiac surgery patient. We wanted to determine the mechanism of this improved coronary conduit and, in addition, to explore the possible benefits with biventricular pacing. Sixteen patients undergoing first time elective coronary artery bypass grafting who required pacing following surgery were recruited. Comparison of cardiac output and coronary conduit flow was performed between VVI and DDD pacing with a single right ventricular lead and biventricular pacing lead placement. Cardiac output was measured using arterial pulse waveform analysis while conduit flow was measured using ultrasonic transit time methodology. Cardiac output was greatest with DDD pacing using right ventricular lead placement only [DDD-univentricular 5.42 l (0.7), DDD-biventricular 5.33 l (0.8), VVI-univentricular 4.71 l (0.8), VVI-biventricular 4.68 l (0.6)]. DDD-univentricular pacing was significantly better than VVI-univentricular (P=0.023) and VVI-biventricular pacing (P=0.001) but there was no significant advantage to DDD-biventricular pacing (P=0.45). In relation to coronary conduit flow, DDD pacing again had the highest flow [DDD-univentricular 55 ml\\/min (24), DDD-biventricular 52 ml\\/min (25), VVI-univentricular 47 ml\\/min (23), VVI-biventricular 50 ml\\/min (26)]. DDD-univentricular pacing was significantly better than VVI-univentricular (P=0.006) pacing but not significantly different to VVI-biventricular pacing (P=0.109) or DDD-biventricular pacing (P=0.171). Pacing with a DDD modality offers the optimal coronary conduit flow by maximising cardiac output. Biventricular lead placement offered no significant benefit to coronary conduit flow or cardiac output.

  7. Einfalt der Vielfalt. Zur Heterogenität als neuer Norm der (Sexual-)Pädagogik

    OpenAIRE

    Dammer, Karl-Heinz

    2015-01-01

    Der Autor befasst sich mit der aktuellen Diskussion zur Schulentwicklung in Baden-Württemberg. Diese dreht sich um den Versuch, in den schulischen Lehrplan die sexuelle Vielfalt zum Thema zu machen. Dem Autor geht es dabei um die sexualpädagogischen Konsequenzen des Diversitätsdiskurses im Hinblick auf Heterogenität und ideologischen Implikationen von Normierung. (DIPF/JS)

  8. [Heinz von zur Mühlen. Auf den Spuren einiger revlaer Firmen und Familien] / Paul Kaegbein

    Index Scriptorium Estoniae

    Kaegbein, Paul

    2007-01-01

    Arvustus: Heinz von zur Mühlen. Auf den Spuren einiger revlaer Firmen und Familien. In : Buch und Bildung im Baltikum. Münster : LIT, 2005, lk. 527-541. Pika tänava majade omanikest alates 17. sajandist - perekonnad Koch, Meyer, Kluge, Ströhm, Wassermann, Glehn, Eggers, Koppelson, Weiss. Nii loob autor pildi Tallinna "firmade ajaloost"

  9. Folgebewertung im vorratsvermögen - Fallstudie zur Vorgehensweise nach IFSR und HGB

    DEFF Research Database (Denmark)

    Quick, Reiner; Warming-Rasmussen, Bent

    2013-01-01

    über die wichstigsten Normen zur Folgebeweriung nach IFSR und HGB sowie zu deren Auslegung. Es schliessen sich ein Fallbeispiel und ein Vorschlag zu dessen Lösung an, in dessen Mittelpunkt sinkende Zeitwerte, die Frage des für die Folgebewerunng relevanten Markts und das Zuschreibungsgebot stehen....

  10. Eine selbstkonsistente Carleman Linearisierung zur Analyse von Oszillatoren

    Directory of Open Access Journals (Sweden)

    H. Weber

    2017-09-01

    Full Text Available Die Analyse nichtlinearer dynamischer Schaltungen ist bis heute eine herausfordernde Aufgabe, da nur selten analytische Lösungen angegeben werden können. Daher wurden eine Vielzahl von Methoden entwickelt, um eine qualitative oder quantitative Näherung für die Lösungen der Netzwerkgleichung zu erhalten. Oftmals wird beispielsweise eine Kleinsignalanalyse mit Hilfe einer Taylorreihe in einem Arbeitspunkt durchgeführt, die nach den Gliedern erster Ordnung abgebrochen wird. Allerdings ist diese Linearisierung nur in der Nähe des stabilen Arbeitspunktes für hyperbolische Systeme gültig. Besonders für die Analyse des dynamischen Verhaltens von Oszillatoren treten jedoch nicht-hyperbolische Systeme auf, sodass diese Methode nicht angewendet werden kann Mathis(2000. Carleman hat gezeigt, dass nichtlineare Differentialgleichungen mit polynomiellen Nichtlinearitäten in ein unendliches System von linearen Differentialgleichungen transformiert werden können Carleman(1932. Wird das unendlichdimensionale Gleichungssystem für numerische Zwecke abgebrochen, kann bei Oszillatoren der Übergang in eine stationäre Schwingung (Grenzzyklus nicht wiedergegeben werden.In diesem Beitrag wird eine selbstkonsistente Carleman Linearisierung zur Untersuchung von Oszillatoren vorgestellt, die auch dann anwendbar ist, wenn die Nichtlinearitäten keinen Polynomen entsprechen. Anstelle einer linearen Näherung um einen Arbeitspunkt, erfolgt mit Hilfe der Carleman Linearisierung eine Approximation auf einem vorgegebenen Gebiet. Da es jedoch mit der selbstkonsistenten Technik nicht möglich ist, das stationäre Verhalten von Oszillatoren zu beschreiben, wird die Berechnung einer Poincaré-Abbildung durchgeführt. Mit dieser ist eine anschließende Analyse des Oszillators möglich.

  11. Eine selbstkonsistente Carleman Linearisierung zur Analyse von Oszillatoren

    Science.gov (United States)

    Weber, Harry; Mathis, Wolfgang

    2017-09-01

    Die Analyse nichtlinearer dynamischer Schaltungen ist bis heute eine herausfordernde Aufgabe, da nur selten analytische Lösungen angegeben werden können. Daher wurden eine Vielzahl von Methoden entwickelt, um eine qualitative oder quantitative Näherung für die Lösungen der Netzwerkgleichung zu erhalten. Oftmals wird beispielsweise eine Kleinsignalanalyse mit Hilfe einer Taylorreihe in einem Arbeitspunkt durchgeführt, die nach den Gliedern erster Ordnung abgebrochen wird. Allerdings ist diese Linearisierung nur in der Nähe des stabilen Arbeitspunktes für hyperbolische Systeme gültig. Besonders für die Analyse des dynamischen Verhaltens von Oszillatoren treten jedoch nicht-hyperbolische Systeme auf, sodass diese Methode nicht angewendet werden kann Mathis (2000). Carleman hat gezeigt, dass nichtlineare Differentialgleichungen mit polynomiellen Nichtlinearitäten in ein unendliches System von linearen Differentialgleichungen transformiert werden können Carleman (1932). Wird das unendlichdimensionale Gleichungssystem für numerische Zwecke abgebrochen, kann bei Oszillatoren der Übergang in eine stationäre Schwingung (Grenzzyklus) nicht wiedergegeben werden. In diesem Beitrag wird eine selbstkonsistente Carleman Linearisierung zur Untersuchung von Oszillatoren vorgestellt, die auch dann anwendbar ist, wenn die Nichtlinearitäten keinen Polynomen entsprechen. Anstelle einer linearen Näherung um einen Arbeitspunkt, erfolgt mit Hilfe der Carleman Linearisierung eine Approximation auf einem vorgegebenen Gebiet. Da es jedoch mit der selbstkonsistenten Technik nicht möglich ist, das stationäre Verhalten von Oszillatoren zu beschreiben, wird die Berechnung einer Poincaré-Abbildung durchgeführt. Mit dieser ist eine anschließende Analyse des Oszillators möglich.

  12. Barrierefreiheit zur Routine machen – Praxisfall: Digitale Bibliothek

    Directory of Open Access Journals (Sweden)

    Susanne Baudisch

    2015-04-01

    Full Text Available Sechs Jahre sind vergangen seit Deutschland am 24. Februar 2009 die Behindertenrechtskonvention der Vereinten Nationen (BRK, die die volle Teilhabe aller Menschen an der Gesellschaft als Menschenrecht festschreibt, ratifizierte. Bereits seit 2002 gibt es in Deutschland ein Behindertengleichstellungsgesetz (BGG, den barrierefreien Zugang zu Informations- und Kommunikationstechnologien regelt die Barrierefreie Informationstechnik-Verordnung (BITV. Aus Sicht des Gesetzgebers sind die Rahmenbedingungen gegeben, Barrierefreiheit gehört inzwischen zum gängigen Vokabular im öffentlichen und teils auch privatwirtschaftlichen Bereich. Längst möchte man meinen, es sei ein alter Hut, Barrierefreiheit als Kernanliegen zu thematisieren oder gar einzufordern. Dies betrifft auch den rasant wachsenden Bereich digitaler Medien, der Wissen und Bildung für jedermann verfügbar macht - oder machen sollte. Vor diesem Hintergrund stellen sich die Autoren der Frage, inwieweit Barrierefreiheit in den digitalen Angeboten wissenschaftlicher und öffentlicher Bibliotheken in Deutschland angekommen ist; ob diese Angebote tatsächlich von allen genutzt werden können. Ausgehend von rechtlichen Grundlagen und Normen werden Formate und Standards für barrierefreie Netzpublikationen an Beispielen diskutiert. Im Fokus stehen einerseits Werkzeuge zum Suchen und Finden digitaler Information (Kataloge und Rechercheoberflächen, andererseits Ausgabeformate digitaler Dokumente (wie XML, PDF, EPUB oder TEI. Den Abschluss bilden Empfehlungen für (Digitale Bibliotheken und deren Verbände, um Barrierefreiheit künftig zur Routine zu machen. Das Fazit: Barrierefreiheit muss gewollt, geplant und sinnvoll umgesetzt werden. Technische Komponenten sind ein wichtiger, doch meist erst der zweite Schritt.

  13. NRC Information No. 90-23: Improper installation of Patel conduit seals

    International Nuclear Information System (INIS)

    Rossi, C.E.

    1992-01-01

    On November 6, 1989, the staff at the H.B. Robinson plant notified the NRC that they had discovered that some of the conduit seal grommets used to seal insulated wire conductors entering environmentally qualified instrument housings were oversized for the application. The seals are used to prevent moisture from entering safety-related electrical components following loss-of-coolant accidents. The problem was attributed to inadequate installation instructions that were used when the seals were installed in 1986 and 1987. These instructions listed the grommets by wire gauge size and gave maximum wire insulation diameters for each wire size. In accordance with these instructions, the seals were selected based on wire gauge alone. However, since the insulation thickness for a given wire gauge the correct grommet size would have been the minimum wire insulation diameter for which a particular grommet will achieve an effective seal. The selection of grommet size based only on wire gauge size resulted in the installation of some grommets that were too large to provide an effective seal. As a result, some of the seals failed pressure tests that were designed to simulate post-LOCA pressures. During the investigation of the grommet leakage problem, the Robinson staff also checked the torque on the conduit seal union nuts that are used to compress the seals. EGS Corporation recommends that the union nuts be torqued to 50 ft-lb. On approximately half of the 90 seals inspected, the union nut moved about 1/4 inch when this torque was applied. EGS Corporation reports that 1/4 inch of movement does not necessarily indicate a degraded seal but recommends that the correct torque be verified on a representative sample of installed conduit seals

  14. Visualized Evaluation of Blood Flow to the Gastric Conduit and Complications in Esophageal Reconstruction.

    Science.gov (United States)

    Noma, Kazuhiro; Shirakawa, Yasuhiro; Kanaya, Nobuhiko; Okada, Tsuyoshi; Maeda, Naoaki; Ninomiya, Takayuki; Tanabe, Shunsuke; Sakurama, Kazufumi; Fujiwara, Toshiyoshi

    2018-03-01

    Evaluation of the blood supply to gastric conduits is critically important to avoid complications after esophagectomy. We began visual evaluation of blood flow using indocyanine green (ICG) fluorescent imaging in July 2015, to reduce reconstructive complications. In this study, we aimed to statistically verify the efficacy of blood flow evaluation using our simplified ICG method. A total of 285 consecutive patients who underwent esophagectomy and gastric conduit reconstruction were reviewed and divided into 2 groups: before and after introduction of ICG evaluation. The entire cohort and 68 patient pairs after propensity score matching (PS-M) were evaluated for clinical outcomes and the effect of visualized evaluation on reducing the risk of complication. The leakage rate in the ICG group was significantly lower than in the non-ICG group for each severity grade, both in the entire cohort (285 subjects) and after PS-M; the rates of other major complications, including recurrent laryngeal nerve palsy and pneumonia, were not different. The duration of postoperative ICU stay was approximately 1 day shorter in the ICG group than in the non-ICG group in the entire cohort, and approximately 2 days shorter after PS-M. Visualized evaluation of blood flow with ICG methods significantly reduced the rate of anastomotic complications of all Clavien-Dindo (CD) grades. Odds ratios for ICG evaluation decreased with CD grade (0.3419 for CD ≥ 1; 0.241 for CD ≥ 2; and 0.2153 for CD ≥ 3). Objective evaluation of blood supply to the reconstructed conduit using ICG fluorescent imaging reduces the risk and degree of anastomotic complication. Copyright © 2017 American College of Surgeons. Published by Elsevier Inc. All rights reserved.

  15. Myectomy and LA-to-LV Conduit for Severe Calcific Mitral Stenosis and Hypertrophic Cardiomyopathy.

    Science.gov (United States)

    Meghji, Zahara; Nguyen, Anita; Geske, Jeffrey B; Schaff, Hartzell V

    2018-02-26

    Severe calcific mitral valve stenosis can rarely occur concomitantly with obstructive hypertrophic cardiomyopathy. In these patients, surgical decalcification of the stenotic mitral valve followed by mitral valve replacement carries significant operative risk and may result in paravalvular leakage, atrioventricular groove disruption, and excessive bleeding. We report the first 2 cases of obstructive hypertrophic cardiomyopathy with severe calcific mitral valve stenosis successfully treated with concomitant transaortic septal myectomy and bypass of the stenotic mitral valve using a valved left atrium to left ventricular conduit. Copyright © 2018 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  16. Robotic Assisted Radical Cystoprostatectomy and Intracorporeal Ileal Conduit Urinary Diversion for a Kidney Transplant Recipient

    Directory of Open Access Journals (Sweden)

    Peter A. Caputo

    Full Text Available ABSTRACT Introduction and Objectives: Robotic assisted radical cystectomy (RARC is an alternative to open radical cystectomy. As experience is gained with the RARC approach the technique is being applied to more complex surgical cases. We describe here our technique for RARC with intracorporeal ileal conduit urinary diversion for a renal transplant recipient. Materials and Methods: The patient is a 60-year old man with high-grade muscle invasive bladder cancer. He has a history of renal failure due to polycystic kidney disease and received a deceased donor renal transplant in 2008. His hospital course at time of transplant was complicated by low-level BK virus viremia. Interestingly his trans-urethral bladder tumor resection specimen at time of bladder cancer diagnosis stained positive for SV40. His native kidneys were anuric so bilateral laparoscopic nephrectomy was performed in a staged fashion 2 weeks prior to RARC. Our surgical technique utilizes 6 trocars, of note a 12-mm assistant trocar is placed 1 cm superior to the pubic symphysis, and this trocar is solely used to pass a laparoscopic stapler to facilitate the excision of the ileal segment and the stapled enteric anastomosis. Surgical steps include: identification of native ureters bilaterally (removed en bloc with the bladder specimen; identification of the transplanted ureter at the right bladder dome; posterior bladder and prostate dissection along Denonvilliers’ fascia; development of the space of Retzius; ligation and transection of the bladder and prostate vascular bundles; apical prostate dissection and transection of urethra; left pelvic lymphadenectomy; ilium resection for creation of the ileal conduit; stapled enteric anastomosis; ureteroileal anastomosis; maturation of the ileal conduit stoma. Results: The surgery had no intraoperative complications. Operative time was 443 minutes (7.4 hours. Estimated blood loss was 250 cc. Length of hospital stay was 5 days. The patient

  17. Clinical experience with an alloplastic stoma prosthesis (Biocarbon) for urinary conduits and cutaneous ureterostomy.

    Science.gov (United States)

    Månsson, W; Harzmann, R

    1988-01-01

    An alloplastic stoma prosthesis, Biocarbon, composed of 99.9% pure carbon in vitreous form, was used in six patients with conduit urinary diversion and in seven with cutaneous ureterostomy. The patients were thereafter observed for 2-86 months. Complications were subcutaneous infection, urinary fistula and ureteral stenosis, which necessitated removal of the prosthesis in most cases. The permanent stoma, without need for adhesive collecting device, was appreciated by the patients. Problems relating to biocompatibility remain to be solved before the place of the stoma prosthesis in urinary diversion can be determined.

  18. Vulcanian explosions at Volcán de Colima, Mexico: modelling the conduit processes

    Science.gov (United States)

    Varley, N. R.; Stevenson, J.; Johnson, J.; Reyes, G.; Weber, K.; Sanderson, R.

    2006-12-01

    Activity at Volcán de Colima has increased over the past 8 years, and is possibly building towards a significant eruption. Monitoring its current activity is therefore critical, with recent expansion of the network providing new types of data which need to be understood. Recent activity has consisted of 3 effusive episodes lasting up to 22 months, separated by periods characterised by daily Vulcanian eruptions of small to moderate size; the largest producing pyroclastic flows reaching over 5 km, representing the most significant since the last Plinian event (1913). A model has been proposed to explain the mechanism of the Vulcanian explosions, derived through integrating different data including seismicity, SO2 flux and the ascent velocity and thermal emission of the eruption column. Infrasound measurements have helped to demonstrate the variability in the distribution of energy produced by the events. Swarms of low frequency seismic events were associated with the largest magnitude explosions and have been examined statistically with variations observed in the magnitude-frequency relationship of each swarm and their distribution. Seismic evidence of migration of the source has been identified, maybe explained by brittle fracturing associated with an increasing pressure differential within the conduit system. Volcán de Colima has a complex edifice structure with explosions switching between multiple vents and showing pulsing. Variation in remotely monitored fumarole temperatures has also been related to the explosive activity. It is clear that small variations of certain critical factors within the conduit system can lead to a transition between effusive and explosive activity. Frequent transitions at Volcán de Colima provide an ideal opportunity to analyse variations in the observable signals and deduce relationships with changes within the conduit that influence magma ascent and degassing, such as its volatile contents or ascent velocity. One goal of this

  19. Incorporation of cooling-induced crystallisation into a 2-dimensional axisymmetric conduit heat flow model

    Science.gov (United States)

    Heptinstall, D. A.; Neuberg, J. W.; Bouvet de Maisonneuve, C.; Collinson, A.; Taisne, B.; Morgan, D. J.

    2015-12-01

    Heat flow models can bring new insights into the thermal and rheological evolution of volcanic systems. We shall investigate the thermal processes and timescales in a crystallizing, static magma column, with a heat flow model of Soufriere Hills Volcano (SHV), Montserrat. The latent heat of crystallization is initially computed with MELTS, as a function of pressure and temperature for an andesitic melt (SHV groundmass starting composition). Three fractional crystallization simulations are performed; two with initial pressures of 34MPa (runs 1 & 2) and one of 25MPa (run 3). Decompression rate was varied between 0.1MPa/°C (runs 1 & 3) and 0.2MPa/°C (run 2). Natural and experimental matrix glass compositions are accurately reproduced by all MELTS runs. The cumulative latent heat released for runs 1, 2 and 3 differs by less than 9% (8.69e5 J/kg*K, 9.32e5 J/kg*K, and 9.49e5 J/kg*K respectively). The 2D axisymmetric conductive cooling simulations consider a 30m-diameter conduit that extends from the surface to a depth of 1500m (34MPa). The temporal evolution of temperature is closely tracked at depths of 10m, 750m and 1400m in the center of the conduit, at the conduit walls, and 20m from the walls into the host rock. Following initial cooling by 7-15oC at 10m depth inside the conduit, the magma temperature rebounds through latent heat release by 32-35oC over 85-123 days to a maximum temperature of 1002-1005oC. At 10 m depth, it takes 4.1-9.2 years for the magma column to cool over 108-130oC and crystallize to 75wt%, at which point it cannot be easily remobilized. It takes 11-31.5 years to reach the same crystallinity at 750-1400m depth. We find a wide range in cooling timescales, particularly at depths of 750m or greater, attributed to the initial run pressure and dominant latent heat producing crystallizing phases (Quartz), where run 1 cools fastest and run 3 cools slowest. Surface cooling by comparison has the strongest influence on the upper tens of meters in all

  20. Measurement of nanosize etched pits in SiO2 optical fiber conduit using AFM

    International Nuclear Information System (INIS)

    Espinosa, G.; Golzarri, J.I.; Vazquez, C.; Fragoso, R.

    2003-01-01

    Fission fragment tracks from 252 Cf have been observed in SiO 2 optical fiber, using an atomic force microscope (AFM), after a very short chemical etching in hydrofluoric acid solution at normal temperature. The nuclear track starting and evolution process is followed by the AFM direct measurements on the material surface and beyond a fine layer of the surface material. The images of the scanned cones were determined observing the two predominant energies from 252 Cf fission fragments and the development of the tracks in the 150 μm diameter optical fiber conduit

  1. Permeability Measurements of Rock Samples from Conduit Drilling at Unzen Volcano, Japan

    Science.gov (United States)

    Watanabe, T.; Shimizu, Y.; Noguchi, S.; Nakada, S.

    2006-12-01

    The last eruption of Unzen Volcano (1990-1995) was effusive to form lava domes, though magmas at depths are estimated to have contained volatile materials enough to cause explosive eruptions [e.g., Sato et al., 1995]. Most of volatile materials should have escaped from ascending magmas. The escape of gas is controlled by permeability of magmas and country rocks. Unzen Scientific Drilling Project sampled both the latest conduit and its country rock (USDP-4). In order to understand degassing processes, we have measured the permeability of these rock samples. Four cube samples with edges of 25 mm were cut from USDP-4 cores C1, C12 (country rock), C13 and C14 (conduit). Sample C1 is considered as Old Unzen Lava, and Sample C12 volcanic breccia. The transient pulse method was employed to measure the permeability. It applies a step of the fluid pressure difference across a specimen, and measures the decay rate of the fluid pressure difference. This method can be applied to samples with very low permeability, since it determines the permeability without measuring the fluid flux. Nitrogen gas was used as a pore fluid. Our permeametry system is built in a pressure vessel, and the confining pressure and the pore fluid pressure can be controlled independently. The temperature of the measurement system is kept constant within 0.1 degree. The temperature control and the background leak rate limit the measurable permeability to be higher than 10^{-20} m2. Measurements were first conducted under the atmospheric pressure. The permeability in a rock sample varies with the direction by a factor less than 5. Sample C1 has the lowest permeability (10^{-19} m2), and Sample C12 the highest value (10^{-17 m2). The permeability of C13 and C14 is of the order of 10^{- 18} m2. Though only a trace of vesicles can be seen in conduit samples, the interconnection is still maintained. The pressure dependence of the permeability is now investigated up to 50 MPa. The permeability of C13 and C14

  2. Review: Holger Stoecker: Afrikawissenschaften in Berlin von 1919 bis 1945. Zur Geschichte und Topographie eines wissenschaftlichen Netzwerkes (2008 Buchbesprechung: Holger Stoecker: Afrikawissenschaften in Berlin von 1919 bis 1945. Zur Geschichte und Topographie eines wissenschaftlichen Netzwerkes

    Directory of Open Access Journals (Sweden)

    Katrin Bromber

    2009-05-01

    Full Text Available Review of the monograph: Holger Stoecker: Afrikawissenschaften in Berlin von 1919 bis 1945. Zur Geschichte und Topographie eines wissenschaftlichen Netzwerkes, Stuttgart: Franz Steiner Verlag 2008, ISBN 978-3-515-09161-9, 359 pages. Besprechung der Monographie: Holger Stoecker: Afrikawissenschaften in Berlin von 1919 bis 1945. Zur Geschichte und Topographie eines wissenschaftlichen Netzwerkes, Stuttgart: Franz Steiner Verlag 2008, ISBN 978-3-515-09161-9, 359 Seiten.

  3. Wildnisbildung als Möglichkeit zur Professionalisierung zukünftiger Geographielehrer/innen – ein neuer Ansatz zur Bildung für nachhaltige Entwicklung?. GW-Unterricht|GW-Unterricht 142/143|

    OpenAIRE

    Lindau, Anne-Kathrin; Hottenroth, Daniela; Lindner, Martin

    2016-01-01

    Der in den deutschen Nationalparken seit mehreren Jahren thematisierte und praktizierte Ansatz der Wildnisbildung stellt möglicherweise einen neuen Zugang zur Bildung für nachhaltige Entwicklung (BNE) in der universitären Lehrer/innenbildung im Fach Geographie dar. Am Beispiel des DBU-geförderten Projektes „Wildnis macht stark“ wird eine Konzeption für die Umsetzung von Wildnisbildung im Rahmen des Geographie-Lehramtsstudiums vorgestellt und mit ersten Forschungsergebnissen zur Wirksamkeit in...

  4. A new venous conduit utilizing the recipient portal vein branches for segment V in adult partial liver transplantation.

    Science.gov (United States)

    Moon, I S; Kim, D G; Lee, M D; Hong, S K; Park, S C; Oh, D Y; Ahn, S T; Lee, Y J

    2005-03-01

    Right anterior-medial lobe congestion due to temporary clamping of segment V and/or VIII is common in the operative theater during adult donor right lobe liver transplantation, the most common procedure in our institute. We have used an autogenous saphenous vein conduit to recipient portal vein tributaries in 15 cases, as a "Y-to-I venoplasty" since January 2004. The recipient portal vein is transected 5 mm proximal to its bifurcation and extended to both sides with partial hepatic dissection. The "Y-to-I venoplasty" is made by suture closure of the portal vein transversely to form a tube. The average length is 7.5 cm with a 1.3 cm width. One end of "Y-to-I venoplasty" conduit is anastomosed to the donor segment V branch on the back table. And the other end is anastomosed directly to the IVC via a new window or the middle hepatic vein stump in recipient. The phase distension of the conduit with respiration is noted in the operative field. A 6/15 (40%) patency rate, was observed by CT angiography at the second postoperative week. All-patient conduits showed good flow on serial examinations at the 60th postoperative day. This new venous graft, made of recipient portal vein is a good conduit for segment V decongestion in adult right lobe partial liver transplantation.

  5. Verfahren zur Hydroformylierung, Liganden mit von Bisphenol A abgeleiteter Struktur und Katalysator umfassend einen Komplex dieser Liganden

    NARCIS (Netherlands)

    2002-01-01

    Die vorliegende Erfindung betrifft ein Verfahren zur Hydroformylierung ethylenisch ungesättigter Verbindungen, wobei man als Hydroformylierungskatalysator wenigstens einen Komplex eines Metalss der VIII. Nebengruppe mit wenigstens einer phosphorhaltigen Verbindung als Liganden einsetzt, wobei diese

  6. Zur linguistischen Beschreibung kommunikativer Einheiten in gesprochener Sprache (On the Linguistic Description of Communicative Units in Oral Language)

    Science.gov (United States)

    Rath, Rainer

    1973-01-01

    Slightly revised version of a lecture ( Zur grammatischen Beschreibung kommunikativer Elemente in Sprechakten'' Y On Grammatical Description of Communicative Elements in Speech''I) presented in Saarbrucken, West Germany, November 10, 1972. (DD)

  7. Robuste Verzweigungserkennung von Gefäßen in CTA-Datensätzen zur modellbasierten Extraktion der Centerline

    Science.gov (United States)

    Beck, Thomas; Fritz, Dominik; Biermann, Christina; Dillmann, Rüdiger

    Bei der Befundung und Visualisierung von Blutgefäßen ist deren Centerline von zentraler Bedeutung. Die Unterscheidung zwischen unverzweigten Abschnitten des Gefäßes und Verzweigungsbereichen ermöglicht den Einsatz spezialisierter und sehr effizienter Algorithmen zur modellbasierten Extraktion der Centerline. In diesem Artikel wird ein robustes Verfahren zur Verzweigungserkennung vorgestellt. Das Verfahren beruht auf einem Front-Propagation-Ansatz mit dynamisch angepassten Schwellwerten und einer anschließenden Clusteranalyse. Die vorgestellte Methode zur Verzweigungserkennung wurde als Komponente einer Architektur zur Extraktion der Centerline auf handannotierten Datensätzen getestet. Erste Ergebnisse sind sehr vielversprechend und ermöglichen auch bei pathologischen Gefäßen eine robuste Detektion von Gefäßverzweigungen.

  8. Auswahl und Verarbeitung von Früchten zur Steigerung der Gehalte an phenolischen Antioxidantien in Fruchtsäften

    OpenAIRE

    Thielen, Christine

    2005-01-01

    Da Polyphenole als gesund angesehen werden, ist es Ziel dieser Arbeit, ihre Gehalte in Fruchtsäften zu erhöhen. Dies beinhaltet zum einen das Auffinden polyphenolreicher Apfel- und Beerenobstsorten als geeignete Rohware. Gleichzeitig entsteht dabei ein Datensatz über sortenreine Apfel- und Beerenobstsäfte, der die RSK-Werte ergänzt. Zum anderen sind Wege zur Minimierung von Verarbeitungsverlusten durch gezielte Studien zur Qualitätssteigerung des Endproduktes Fruchtsaft wichtig. Die im Screen...

  9. Conduit degassing and thermal controls on eruption styles at Mount St. Helens

    Science.gov (United States)

    Schneider, Andrew; Rempel, Alan W.; Cashman, Katharine V.

    2012-12-01

    The explosivity of silicic eruptions depends on the interplay between magma rheology, exsolution kinetics, and degassing. Magma degassing is governed by the competing effects of vertical transport within the conduit and the lateral flux of gas out of the conduit (Diller et al., 2006; Jaupart and Allegre, 1991). We combine a simplified treatment of these degassing processes with thermodynamic modeling to examine the conditions present at Mount St. Helens during the spine extruding eruption from 2004 to 2008. We find that two parameters are primarily responsible for controlling the eruptive style: the magma chamber temperature, and a dimensionless parameter that gauges the efficiency of lateral degassing. Together, these parameters determine whether and where magma can solidify at depth to form a dense solid plug that is gradually extruded as a volcanic spine. We show that the small (50 oC) decrease in magma chamber temperature between eruptive activity in the 1980s and that of 2004-2008, combined with a modest increase in degassing efficiency associated with lower volumetric flux, can explain the observed change in erupted material from viscous lava flows to solidified spines. More generally, we suggest that similar threshold behavior may explain observed abrupt transitions in effusive eruptive styles at other intermediate composition volcanoes. Finally, we extrapolate our results to suggest that the increase in degassing efficiency accompanying decreasing magma supply rates may have caused the transition from explosive to effusive activity in late 1980.

  10. Age-related changes in biomechanical properties of transgenic porcine pulmonary and aortic conduits

    International Nuclear Information System (INIS)

    Wilczek, Piotr; Malota, Zbigniew; Lesiak, Anna; Niemiec-Cyganek, Aleksandra; Kubin, Barbara; Nozynski, Jerzy; Mzyk, Aldona; Gramatyka, Michalina; Slomski, Ryszard; Wilczek, Grazyna; Opiela, Jolanta

    2014-01-01

    The limitations associated with conventional valve prosthesis have led to a search for alternatives. One potential approach is tissue engineering. Most tissue engineering studies have described the biomechanical properties of heart valves derived from adult pigs. However, because one of the factors affecting the function of valve prosthesis after implantation is appropriate sizing for a given patient, it is important to evaluate the usefulness of a heart valve given the donor animal’s weight and age. The aim of this study was to evaluate how the age of a pig can influence the biomechanical and hemodynamical properties of porcine heart valve prosthesis after acellularization. Acellular porcine aortic and pulmonary valve conduits were used. Hearts were harvested from animals differing in weight and age. The biomechanical properties of the valves were then characterized using a uniaxial tensile test. Moreover, computer simulations based on the finite element method (FEM) were used to study the influence of biomechanical properties on the hemodynamic conditions. Studying biomechanical and morphological changes in porcine heart valve conduits according to the weight and age of the animals can be valuable for developing age-targeted therapy using tissue engineering techniques. (paper)

  11. Impact of asymmetric lamp positioning on the performance of a closed-conduit UV reactor

    Directory of Open Access Journals (Sweden)

    Tipu Sultan

    2017-06-01

    Full Text Available Computational fluid dynamics (CFD analyses for the performance improvement of a closed-conduit ultraviolet (UV reactor were performed by changing the lamp positions from symmetric to asymmetric. The asymmetric lamp positioning can be useful for UV reactor design and optimization. This goal was achieved by incorporating the two performance factors, namely reduction equivalent dose (RED and system dose performance. Four cases were carried out for asymmetric lamp positioning within the UV reactor chamber and each case consisted of four UV lamps that were simulated once symmetrically and four times asymmetrically. The results of the four asymmetric cases were compared with the symmetric one. Moreover, these results were evaluated by using CFD simulations of a closed-conduit UV reactor. The fluence rate model, UVCalc3D was employed to validate the simulations results. The simulation results provide detailed information about the dose distribution, pathogen track modeling and RED. The RED value was increased by approximately 15% by using UVCalc3D fluence rate model. Additionally, the asymmetric lamp positioning of the UV lamps had more than 50% of the pathogens received a better and a higher UV dose than in the symmetric case. Consequently, the system dose performance was improved by asymmetric lamp positioning. It was concluded that the performance parameters (higher RED and system dose performance were improved by using asymmetric lamp positioning.

  12. Experimental study on scale removal from special-shaped conduits through underwater electrical discharge

    International Nuclear Information System (INIS)

    Cao, Y; Wang, Z Q; Li, G F; Wu, Y; Zhou, J J

    2013-01-01

    Underwater electrical discharge technology is an innovative technique that can be used to enhance the stress intensity of water and improve the load addition. The technique enlarges the section area and compresses the surrounding water using a high-powered shock wave, which is induced by an underwater electrical discharge. This paper investigates the effectiveness of scale removal for special-shaped conduits employing underwater electrical discharge. Experimental results show that the pressure wave generated by underwater electrical discharge is capable of eliminating scale in special-shaped conduits. The data indicates that when the capacitance of the parallel-pulsed capacitors was 4 μF, the high pulsed power voltage was 33 kV and the primary discharge gap was 48 mm, the result of scale removal was remarkable. In laboratory tests, the scale of special equipment was removed to a great extent by this method. Because of its effectiveness and low cost, this method improves the practice and extends the lifetime of such equipment, and thus has potential application and economic value.

  13. Rapid prototyping of a double-layer polyurethane-collagen conduit for peripheral nerve regeneration.

    Science.gov (United States)

    Cui, Tongkui; Yan, Yongnian; Zhang, Renji; Liu, Li; Xu, Wei; Wang, Xiaohong

    2009-03-01

    A new technique for preparing double-layer polyurethane (PU)-collagen nerve conduits for peripheral nerve repair via a double-nozzle, low-temperature, deposition manufacturing (DLDM) system has been developed. The DLDM system is based on a digital prototyping approach, and uses a combination of thermally induced phase separation and freeze-drying. With this system, two kinds of biomaterials with different properties can be combined to produce scaffold structures with good biocompatibility in the inner layer and with the desired mechanical strength protruded by the outer. The forming precision is high, the wall thickness can be controlled, and a tight connection between the two layers can be achieved. The effects of changing the processing parameters and the material temperature on the structure of the scaffolds have been investigated. Additionally, the effect of material concentration on the mechanical strength and hydrophilic properties of the scaffolds has also been studied. Ideal peripheral nerve repair conduits, comprising an outer microporous layer of PU and internal oriented filaments of collagen, have been manufactured through optimizing the processing parameters and the biomaterial concentrations.

  14. Bacillus licheniformis Contains Two More PerR-Like Proteins in Addition to PerR, Fur, and Zur Orthologues.

    Directory of Open Access Journals (Sweden)

    Jung-Hoon Kim

    Full Text Available The ferric uptake regulator (Fur family proteins include sensors of Fe (Fur, Zn (Zur, and peroxide (PerR. Among Fur family proteins, Fur and Zur are ubiquitous in most prokaryotic organisms, whereas PerR exists mainly in Gram positive bacteria as a functional homologue of OxyR. Gram positive bacteria such as Bacillus subtilis, Listeria monocytogenes and Staphylococcus aureus encode three Fur family proteins: Fur, Zur, and PerR. In this study, we identified five Fur family proteins from B. licheniformis: two novel PerR-like proteins (BL00690 and BL00950 in addition to Fur (BL05249, Zur (BL03703, and PerR (BL00075 homologues. Our data indicate that all of the five B. licheniformis Fur homologues contain a structural Zn2+ site composed of four cysteine residues like many other Fur family proteins. Furthermore, we provide evidence that the PerR-like proteins (BL00690 and BL00950 as well as PerRBL (BL00075, but not FurBL (BL05249 and ZurBL (BL03703, can sense H2O2 by histidine oxidation with different sensitivity. We also show that PerR2 (BL00690 has a PerR-like repressor activity for PerR-regulated genes in vivo. Taken together, our results suggest that B. licheniformis contains three PerR subfamily proteins which can sense H2O2 by histidine oxidation not by cysteine oxidation, in addition to Fur and Zur.

  15. Bacillus licheniformis Contains Two More PerR-Like Proteins in Addition to PerR, Fur, and Zur Orthologues

    Science.gov (United States)

    Ju, Shin-Yeong; Yang, Yoon-Mo; Ryu, Su-Hyun; Kwon, Yumi; Won, Young-Bin; Lee, Yeh-Eun; Youn, Hwan; Lee, Jin-Won

    2016-01-01

    The ferric uptake regulator (Fur) family proteins include sensors of Fe (Fur), Zn (Zur), and peroxide (PerR). Among Fur family proteins, Fur and Zur are ubiquitous in most prokaryotic organisms, whereas PerR exists mainly in Gram positive bacteria as a functional homologue of OxyR. Gram positive bacteria such as Bacillus subtilis, Listeria monocytogenes and Staphylococcus aureus encode three Fur family proteins: Fur, Zur, and PerR. In this study, we identified five Fur family proteins from B. licheniformis: two novel PerR-like proteins (BL00690 and BL00950) in addition to Fur (BL05249), Zur (BL03703), and PerR (BL00075) homologues. Our data indicate that all of the five B. licheniformis Fur homologues contain a structural Zn2+ site composed of four cysteine residues like many other Fur family proteins. Furthermore, we provide evidence that the PerR-like proteins (BL00690 and BL00950) as well as PerRBL (BL00075), but not FurBL (BL05249) and ZurBL (BL03703), can sense H2O2 by histidine oxidation with different sensitivity. We also show that PerR2 (BL00690) has a PerR-like repressor activity for PerR-regulated genes in vivo. Taken together, our results suggest that B. licheniformis contains three PerR subfamily proteins which can sense H2O2 by histidine oxidation not by cysteine oxidation, in addition to Fur and Zur. PMID:27176811

  16. [Philipp Herzog: Sozialistische Völkerfreundschaft nationaler Widerstand oder harmloser Zeitvertieb? Zur politischen Funktion der Volkskunst im sowjetischen Estland] / Karsten Brüggemann

    Index Scriptorium Estoniae

    Brüggemann, Karsten, 1965-

    2014-01-01

    Arvustus: Herzog, Philipp. Sozialistische Völkerfreundschaft, nationaler Widerstand oder harmloser Zeitvertreib? : zur politischen Funktion der Volkskunst im sowjetischen Estland. Stuttgart : Ibidem-Verlag, 2012

  17. Pericardial tissue valves and Gore-Tex conduits as an alternative for right ventricular outflow tract replacement in children.

    Science.gov (United States)

    Allen, Bradley S; El-Zein, Chawki; Cuneo, Betina; Cava, Joseph P; Barth, Mary Jane; Ilbawi, Michel N

    2002-09-01

    There is still no perfect conduit for reconstruction of the right ventricular outflow tract (RVOT) in children. Homografts are not always available in the appropriate size, and degenerate in a few years. This study evaluates the pericardial valve with Gore-Tex conduit as an alternative for RVOT construction. From January 1, 1993, to September 30, 1999, a pericardial tissue valve was inserted in all patients undergoing RVOT reconstruction or pulmonary valve replacement (PVR) who were large enough to accommodate a tissue valve. In patients without a native main pulmonary artery, a new technique was used to construct an RV-PA conduit out of a flat sheet of Gore-Tex, as Dacron frequently leads to stenosis. Data were collected by retrospective review, follow-up echocardiograms, and assessment by a single cardiologist. There were 48 patients, 22 undergoing a PVR alone and 26 a RV-PA valved Gore-Tex conduit. Diagnosis included tetralogy of Fallot (n = 25); truncus arteriosis (n = 9); ventricular septal defect with PA (n = 5); DORV (n = 4); D-TGA with PS (n = 2); and 1 each IAA with sub AS, VSD with PI, and PS s/p Ross procedure. Patient age ranged from 3 to 33 years and 98% were reoperations. The valve sizes ranged from 19 to 33 mm and the median hospital length of stay was 4 days. There were 2 (4.2%) perioperative and 1 (2.1%) late deaths, none related to the valve or Gore-Tex conduit. At a follow-up of 15 to 86 months (mean 43 +/- 16 months), all remaining 45 patients are New York Heart Association class I, all valves are functional, and no patient has required valve or conduit replacement or revision; more importantly, echocardiogram revealed no significant valve or conduit stenosis (mean gradient 16 +/- 8 mm Hg) and no evidence of regurgitation or structural degeneration. A pericardial tissue valve and Gore-Tex conduit provides a reliable alternative for RVOT reconstruction in pediatric patients. It is readily available, molds in the limited retrosternal space, and

  18. Models for settlement prediction of structures in opencast dumps; Modelle zur Setzungsprognose von Bauwerken auf Tagebaukippen

    Energy Technology Data Exchange (ETDEWEB)

    Birle, E.; Vogt, S. [Technische Univ. Muenchen (Germany). Zentrum Geotechnik

    2016-05-01

    For construction projects at opencast dumps e.g. for planning of traffic routes or individual buildings a prognosis of dump subsicence after the establishment of the structures is required. It should be noted that on dump surfaces time-dependent subsidence are observed which can change by construction activities at the dump surface. As tools for describing the dump subsidence phenomenological models that have been developed based on the evaluation of dump characteristic subsidence and allow a one-dimensional analysis of creep deformation and visco-elastoplastic material models within the finite element method for analyzing complex geometric boundary conditions. [German] Fuer Baumassnahmen auf Tagebaukippen beispielsweise zur Planung von Verkehrswegen oder einzelnen Bauwerken ist eine Prognose der Kippensetzungen nach Errichtung der Bauwerke erforderlich. Dabei ist zu beachten, dass auf Kippenoberflaechen ausgepraegte zeitabhaengige Setzungen beobachtet werden, die sich durch Baumassnahmen an der Kippenoberflaeche aendern koennen. Als Werkzeuge zur Beschreibung der Kippensetzungen stehen prinzipiell phaenomenologische Modelle, die auf Basis der Auswertung von Kippeneigensetzungen entwickelt wurden und die eine ein-dimensionale Analyse der Kriechverformungen zulassen sowie visko-elastoplastische Stoffmodelle im Rahmen der FiniteElemente- Methode zur Analyse komplexer geometrischer Randbedingungen zur Verfuegung. In Abhaengigkeit vom Randwertproblem ist zu entscheiden, welches der Modelle zur Beschreibung der Kippensetzungen heranzuziehen ist. Mit phaenomenologischen Kriechmodellen und einer ein-dimensionalen Analyse der Verformungen koennen die sich nach Ende der Verkippung einstellenden Kippensetzungen in der Regel genuegend genau beschrieben werden, sofern an der Kippenoberflaeche keine signifikanten Spannungsaenderungen infolge von Baumassnahmen eingetragen werden. Kommt es dagegen zu Spannungsaenderungen, beispielsweise durch die Errichtung eines hohen

  19. Experimental sintering of ash at conduit conditions and implications for the longevity of tuffisites

    Science.gov (United States)

    Gardner, James E.; Wadsworth, Fabian B.; Llewellin, Edward W.; Watkins, James M.; Coumans, Jason P.

    2018-03-01

    Escape of gas from magma in the conduit plays a crucial role in mitigating explosivity. Tuffisite veins—ash-filled cracks that form in and around volcanic conduits—represent important gas escape pathways. Sintering of the ash infill decreases its porosity, eventually forming dense glass that is impermeable to gas. We present an experimental investigation of surface tension-driven sintering and associated densification of rhyolitic ash under shallow conduit conditions. Suites of isothermal (700-800 °C) and isobaric H2O pressure (20 and 40 MPa) experiments were run for durations of 5-90 min. Obsidian powders with two different size distributions were used: 1-1600 μm (mean size = 89 μm), and 63-400 μm (mean size = 185 μm). All samples evolved similarly through four textural phases: phase 1—loose and cohesion-less particles; phase 2—particles sintered at contacts and surrounded by fully connected tortuous pore space of up to 40% porosity; phase 3—continuous matrix of partially coalesced particles that contain both isolated spherical vesicles and connected networks of larger, contorted vesicles; phase 4—dense glass with 2-5% fully isolated vesicles that are mainly spherical. Textures evolve faster at higher temperature and higher H2O pressure. Coarse samples sinter more slowly and contain fewer, larger vesicles when fully sintered. We quantify the sintering progress by measuring porosity as a function of experimental run-time, and find an excellent collapse of data when run-time is normalized by the sintering timescale {λ}_s=η \\overline{R}/σ , where η is melt viscosity, \\overline{R} is mean particle radius, and σ is melt-gas surface tension. Because timescales of diffusive H2O equilibration are generally fast compared to those of sintering, the relevant melt viscosity is calculated from the solubility H2O content at experimental temperature and pressure. We use our results to develop a framework for estimating ash sintering rates under shallow

  20. [Electrophysiological study on rat conduit pulmonary artery smooth muscle cells under normoxia and acute hypoxia].

    Science.gov (United States)

    Hu, Ying; Zou, Fei; Cai, Chun-Qing; Wu, Hang-Yu; Yun, Hai-Xia; Chen, Yun-Tian; Jin, Guo-En; Ge, Ri-Li

    2006-10-25

    The present study was designed to investigate the electrophysiological characteristics of rat conduit pulmonary artery smooth muscle cells (PASMCs) and the response to acute hypoxia. PASMCs of the 1st to 2nd order branches in the conduit pulmonary arteries were obtained by enzymatic isolation. The PASMCs were divided into acute hypoxia preconditioned group and normoxia group. Hypoxia solutions were achieved by bubbling with 5% CO2 plus 95% N2 for at least 30 min before cell perfusion. Potassium currents were compared between these two groups using whole-cell patch clamp technique. The total outward current of PASMCs was measured under normoxia condition when iBTX [specific blocking agent of large conductance Ca-activated K(+) (BK(Ca)) channel] and 4-AP [specific blocking agent of delayed rectifier K(+) (K(DR)) channel] were added consequently into bath solution. PASMCs were classified into three types according to their size, shape and electrophysiological characteristics. Type I cells are the smallest with spindle shape, smooth surface and discrete perinuclear bulge. Type II cells show the biggest size with banana-like appearance. Type III cells have the similar size with type I, and present intermediary shape between type I and type II. iBTX had little effect on the total outward current in type I cells, while 4-AP almost completely blocked it. Most of the total outward current in type II cells was inhibited by iBTX, and the remaining was sensitive to 4-AP. In type III cells, the total outward current was sensitive to both iBTX and 4-AP. Acute hypoxia reduced the current in all three types of cells: (1614.8+/-62.5) pA to (892.4+/-33.6) pA for type I cells (Ppotassium current and improves the E(m) in PASMCs. These effects may be involved in the modulation of constriction/relaxation of conduit artery under acute hypoxia. Different distribution of K(DR) and BK(Ca) channels in these three types of PASMCs might account for their different constriction

  1. Permeability and 3-D melt geometry in shear-induced high melt fraction conduits

    Science.gov (United States)

    Zhu, W.; Cordonnier, B.; Qi, C.; Kohlstedt, D. L.

    2017-12-01

    Observations of dunite channels in ophiolites and uranium-series disequilibria in mid-ocean ridge basalt suggest that melt transport in the upper mantle beneath mid-ocean ridges is strongly channelized. Formation of high melt fraction conduits could result from mechanical shear, pyroxene dissolution, and lithological partitioning. Deformation experiments (e.g. Holtzman et al., 2003) demonstrate that shear stress causes initially homogeneously distributed melt to segregate into an array of melt-rich bands, flanked by melt-depleted regions. At the same average melt fraction, the permeability of high melt fraction conduits could be orders of magnitude higher than that of their homogenous counterparts. However, it is difficult to determine the permeability of melt-rich bands. Using X-ray synchrotron microtomography, we obtained high-resolution images of 3-dimensional (3-D) melt distribution in a partially molten rock containing shear-induced high melt fraction conduits. Sample CQ0705, an olivine-alkali basalt aggregate with a nominal melt fraction of 4%, was deformed in torsion at a temperature of 1473 K and a confining pressure of 300 MPa to a shear strain of 13.3. A sub-volume of CQ0705 encompassing 3-4 melt-rich bands was imaged. Microtomography data were reduced to binary form so that solid olivine is distinguishable from basalt glass. At a spatial resolution of 160 nm, the 3-D images reveal the shape and connectedness of melt pockets in the melt-rich bands. Thin melt channels formed at grain edges are connected at large melt nodes at grain corners. Initial data analysis shows a clear preferred orientation of melt pockets alignment subparallel to the melt-rich band. We use the experimentally determined geometrical parameters of melt topology to create a digital rock with identical 3-D microstructures. Stokes flow simulations are conducted on the digital rock to obtain the permeability tensor. Using this digital rock physics approach, we determine how deformation

  2. NECL1 coated PLGA as favorable conduits for repair of injured peripheral nerve

    International Nuclear Information System (INIS)

    Xu, Fuben; Zhang, Kun; Lv, Peizhen; Lu, Rongbin; Zheng, Li; Zhao, Jinmin

    2017-01-01

    Restoration of normal neurological function of transected peripheral nerve challenged regenerative medicine and surgery. Previous studies showed that Nectin-like molecule 1 (NECL1) is one of the important adhesion molecules on the axons and Schwann cells is located along the internodes in direct apposition to NECL1. In this study, we fabricated PLGA membrane pre-coated with NECL1, mimicking the natural axons to enhance the adhesion of Schwann cells. Investigation of the cellular response in vitro was performed by detecting cytotoxicity, proliferation, morphology, viability, specific markers and Scanning Electron Microscopy (SEM) of Schwann cells cultured in PLGA. Further, the NECL1-coated PLGA conduits were used for peripheral nerve repair after sciatic nerve defect was constructed. Results showed that PLGA-coated NECL1 enhanced cell proliferation compared with PLGA, as evidenced by MTT analysis, cell viability assay and histological evaluation. RT-PCR results showed that GDNF (glial cell line-derived neurotrophic factor), BDNF (brain-derived neurotrophic factor), CNTF (ciliary neurotrophic factor) and neurotrophic factors of axonal regeneration were highly expressed in PLGA/NECL1 group. S100, which is Schwann cell marker, was also elevated in PLGA-NCEL1 in both mRNA and protein expression as demonstrated by PCR and immunohistochemical examination. Moreover, in vivo study showed that implantation of PLGA/NCEL1 tubes in bridging the nerve defect can significantly improve Schwann cell aggregation and attachment and greatly enhance the functional recovery of nerve regeneration as compared with control and PLGA groups. Therefore, the novel blend of PLGA/NECL1 conduits proved to be promising candidate for tissue engineering scaffold. - Highlights: • A fabricated PLGA tubes pre-coated with Nectin-like molecule 1 (NECL1) strategy for sciatic nerve regeneration is proposed. • The NECL1 coated PLGA can promote Schwann cells adhesion and growth meanwhile maintain the

  3. Combined use of decellularized allogeneic artery conduits with autologous transdifferentiated adipose-derived stem cells for facial nerve regeneration in rats.

    Science.gov (United States)

    Sun, Fei; Zhou, Ke; Mi, Wen-juan; Qiu, Jian-hua

    2011-11-01

    Natural biological conduits containing seed cells have been widely used as an alternative strategy for nerve gap reconstruction to replace traditional nerve autograft techniques. The purpose of this study was to investigate the effects of a decellularized allogeneic artery conduit containing autologous transdifferentiated adipose-derived stem cells (dADSCs) on an 8-mm facial nerve branch lesion in a rat model. After 8 weeks, functional evaluation of vibrissae movements and electrophysiological assessment, retrograde labeling of facial motoneurons and morphological analysis of regenerated nerves were performed to assess nerve regeneration. The transected nerves reconstructed with dADSC-seeded artery conduits achieved satisfying regenerative outcomes associated with morphological and functional improvements which approached those achieved with Schwann cell (SC)-seeded artery conduits, and superior to those achieved with artery conduits alone or ADSC-seeded artery conduits, but inferior to those achieved with nerve autografts. Besides, numerous transplanted PKH26-labeled dADSCs maintained their acquired SC-phenotype and myelin sheath-forming capacity inside decellularized artery conduits and were involved in the process of axonal regeneration and remyelination. Collectively, our combined use of decellularized allogeneic artery conduits with autologous dADSCs certainly showed beneficial effects on nerve regeneration and functional restoration, and thus represents an alternative approach for the reconstruction of peripheral facial nerve defects. Copyright © 2011 Elsevier Ltd. All rights reserved.

  4. Flow-rate measurements in closed-conduits by tracer techniques

    International Nuclear Information System (INIS)

    Lund Plantat, C.

    1982-01-01

    This paper presents the study of the precision obtained measuring flow-rates in closed-conduits by tracer techniques. The flow-rates analyzed were in the range of 10 to 20 l/s and Reynolds numbers from 10 5 to 2 x 10 5 . Tracer used were fluoresceine and In-113 m; and the measurements were performed with the dilution method (punctual and continuous injection) and the Allen method. Precisions for the method of punctual and continuous injections were 6.25% and 9.45% for fluoresceine and 9.3% and 3% for In-113, respectively. For Allen method with In-113 m a precision of 5% was obtained; probably this value was affected by the short distance between detectors. In all cases the error corresponds with the expected value except in one measurement at a 68.3% confidence level. (I.V.)

  5. Detection of the normal zone with cowound sensors in cable-in conduit conductors

    International Nuclear Information System (INIS)

    Martovetsky, N.N.; Chaplin, M.R.

    1996-01-01

    Tokamaks in the future will use superconducting cable-in-conduit- conductors (CICC) in all poloidal field (PF) and toroidal field (TF) magnets. Conventional quench detection, the measurement of small resistive normal zone voltages ( 4 kV). In the quench detection design for TPX, we have considered several different locations for internal co-wound voltage sensors in the cable cross-section as the primary mechanism to cancel this inductive noise. The Noise Rejection Experiment (NRE) at LLNL has been designed to evaluate which internal locations will produce the best inductive- noise cancellation, and provide us with experimental data for comparison with previously developed theory. The details of the experiments and resulting data are presented and analyzed

  6. Quench detection by fluid dynamic means in cable-in-conduit superconductors

    International Nuclear Information System (INIS)

    Dresner, L.

    1988-01-01

    The tight confinement of the helium in cable-in-conduit superconductors creates protection problems because of the pressure rise that can occur during a quench. But the same pressure rise offers the possibility of a non-electrical means of detecting incipient quenches by monitoring the outflow from the various hydraulic paths of the magnet. If the method is to work, the signal must be large enough to be detected unambiguously at an early time, and must not depend too strongly on the length, Joule power density, or rate of growth of the initial normal zone. This paper explores by calculation the degree to which these conditions can be met. The Westinghouse Large Coil Task coil is used as an example

  7. Le projet de recherche: définition, conduite et réalisation

    OpenAIRE

    Stockinger , Peter

    2013-01-01

    Master; Ce support de séminaire développe brièvement les quatre points suivants: 1) Définition d’un projet de recherche – présentation générale et recommandations. 2) La conduite d’un projet de recherche – présentation générale et recommandations. 3) La réalisation d’un projet de recherche sous forme d’un mémoire - présentation générale et recommandations. 4) Des ressources pour conduire un projet de recherche : ressources enligne et références bibliographiques.

  8. A novel approach to estimate the eruptive potential and probability in open conduit volcanoes.

    Science.gov (United States)

    De Gregorio, Sofia; Camarda, Marco

    2016-07-26

    In open conduit volcanoes, volatile-rich magma continuously enters into the feeding system nevertheless the eruptive activity occurs intermittently. From a practical perspective, the continuous steady input of magma in the feeding system is not able to produce eruptive events alone, but rather surplus of magma inputs are required to trigger the eruptive activity. The greater the amount of surplus of magma within the feeding system, the higher is the eruptive probability.Despite this observation, eruptive potential evaluations are commonly based on the regular magma supply, and in eruptive probability evaluations, generally any magma input has the same weight. Conversely, herein we present a novel approach based on the quantification of surplus of magma progressively intruded in the feeding system. To quantify the surplus of magma, we suggest to process temporal series of measurable parameters linked to the magma supply. We successfully performed a practical application on Mt Etna using the soil CO2 flux recorded over ten years.

  9. Faulting within the Mount St. Helens conduit and implications for volcanic earthquakes

    Science.gov (United States)

    Pallister, John S.; Cashman, Katharine V.; Hagstrum, Jonathan T.; Beeler, Nicholas M.; Moran, Seth C.; Denlinger, Roger P.

    2013-01-01

    The 2004–2008 eruption of Mount St. Helens produced seven dacite spines mantled by cataclastic fault rocks, comprising an outer fault core and an inner damage zone. These fault rocks provide remarkable insights into the mechanical processes that accompany extrusion of degassed magma, insights that are useful in forecasting dome-forming eruptions. The outermost part of the fault core consists of finely comminuted fault gouge that is host to 1- to 3-mm-thick layers of extremely fine-grained slickenside-bearing ultracataclasite. Interior to the fault core, there is an ∼2-m-thick damage zone composed of cataclastic breccia and sheared dacite, and interior to the damage zone, there is massive to flow-banded dacite lava of the spine interior. Structures and microtextures indicate entirely brittle deformation, including rock breakage, tensional dilation, shearing, grain flow, and microfaulting, as well as gas and fluid migration through intergranular pores and fractures in the damage zone. Slickenside lineations and consistent orientations of Riedel shears indicate upward shear of the extruding spines against adjacent conduit wall rocks.Paleomagnetic directions, demagnetization paths, oxide mineralogy, and petrology indicate that cataclasis took place within dacite in a solidified steeply dipping volcanic conduit at temperatures above 500 °C. Low water content of matrix glass is consistent with brittle behavior at these relatively high temperatures, and the presence of tridymite indicates solidification depths of <1 km. Cataclasis was coincident with the eruption’s seismogenic zone at <1.5 km.More than a million small and low-frequency “drumbeat” earthquakes with coda magnitudes (Md) <2.0 and frequencies <5 Hz occurred during the 2004–2008 eruption. Our field data provide a means with which to estimate slip-patch dimensions for shear planes and to compare these with estimates of slip patches based on seismic moments and shear moduli for dacite rock and

  10. The federations' agreement II on network utilisation; Die Verbaendevereinbarung II zur Netznutzung

    Energy Technology Data Exchange (ETDEWEB)

    Birkner, P. [Lech-Elektrizitaetswerke AG, Augsburg (Germany)

    2001-06-18

    Against the background of the experience of the regional supplier Lech Elektrizitaetswerke AG (LEW AG) and in the view of the operator of a regional distribution network the author deals with three complexes of themes: 1. Federations' Agreement II on network utilisation - Flexible instrument for competition or unsuited attempt? 2. What progress and obstacles are identifiable on route towards the implementation of the Federations' Agreement II on network utilisation? 3. What adjustment of existing sets of rules towards the requirements of competition is necessary? (orig.) [German] Vor dem Erfahrungshintergrund des Erfahrungsbereiches des Regionalversorgers Lech-Elektrizitaetswerke AG (LEW AG) und aus der Sicht des Betreibers eines regionalen Verteilungsnetzes behandelt der Verfasser die drei Themenkomplexe: 1. Verbaendevereinbarung II zur Netznutzung - Flexibles Instrument fuer den Wettbewerb oder ungeeigneter Versuch? 2. Welche Fortschritte und Hindernisse sind auf dem Wege der Umsetzung der Verbaendevereinbarung II zur Netznutzung erkennbar? 3. Welche Anpassung vorhandener Regelwerke an die Erfordernisse des Wettbewerbs sind notwendig? (orig.)

  11. Anleitung zur Gründung und Pflege von Online-Netzwerken

    Directory of Open Access Journals (Sweden)

    Nicola Döring

    2006-11-01

    Full Text Available Internet-Nutzung ist in der weiblichen Bevölkerung geringer verbreitet als in der männlichen (Internet Gender Gap. Hinzu kommen geschlechtsspezifische Unterschiede in Umfang und Art der Internet-Aneignung (Gendered Digital Inequalities. Eine Reihe von Initiativen bemüht sich darum, Mädchen und Frauen den Internet-Zugang zu erleichtern und ihre Internet-Kompetenz zu steigern (z. B. www.frauen-ans-netz.de. Der vorliegende Praxisleitfaden geht einen Schritt weiter und möchte nicht nur zur Internet-Nutzung, sondern zur aktiven Internet-Gestaltung anregen im Sinne der Gründung neuer virtueller Mädchen- und Frauennetzwerke. Technologische, ökonomische, soziale, psychologische und geschlechterpolitische Aspekte dieser Netzwerke werden behandelt und an Beispielen illustriert.

  12. Magma shearing and friction in the volcanic conduit: A crystal constraint

    Science.gov (United States)

    Wallace, P. A.; Kendrick, J. E.; Henton De Angelis, S.; Ashworth, J. D.; Coats, R.; Miwa, T.; Mariani, E.; Lavallée, Y.

    2017-12-01

    Magma shearing and friction processes in the shallow volcanic conduit are typical manifestations of strain localisation, which in turn can have an influential role on magma ascent dynamics. The thermal consequences of such events could drive the destabilisation of magma and thus dictate the style of activity at the surface. Shear heating and fault friction are prime candidates for the generation of significant quantities of heat. Here we use a combination of field and experimental evidence to investigate how crystals can act as sensitive recorders of both physical and chemical processes occurring in the shallow volcanic conduit. Spine extrusion during the closing of the 1991-95 eruption at Unzen volcano, Japan, provided the unique opportunity to investigate marginal shear zone formation, which preserves a relic of the deformation during magma ascent. Our results show that crystals can effectively act as a deformation marker during magma ascent through the viscous-brittle transition by accommodating strain in the form of crystal plasticity before fracturing (comminution). Electron backscatter diffraction (EBSD) reveals up to 40° lattice distortion of biotite phenocrysts in zones of high shear, with negligible plasticity further away. Plagioclase microlites display a systematic plastic response to an increase in shear intensity, as recorded by an increase in lattice distortion towards the spine margin of up to 9°. This localisation of strain within the shear zone is also accompanied by the destabilisation of hydrous mineral phases (i.e. amphibole), compaction of pores (23-13% Φ), glass devitrification and magnetic anomalies. The narrow zone of disequilibrium textures suggests the likely effect of a thermal input due to strain localisation being the contributing factor. These observations are complimented by high-temperature high-velocity rotary shear experiments which simulate the deformation evolution during shear. Hence, understanding these shallow volcanic

  13. Frictional melting dynamics in the upper conduit: A chemical answer to a complex physical question

    Science.gov (United States)

    Henton De Angelis, S.; Lavallee, Y.; Kendrick, J. E.; Hornby, A.; von Aulock, F. W.; Clesham, S.; Hirose, T.; Perugini, D.

    2013-12-01

    During volcanic eruptions the generation of frictional heat along the walls of the shallow conduit leads to melting of the rocks along the slip interface. Frictional melting has previously been described as a process out of thermodynamic equilibrium, but upon slip and mingling of the melt batches, homogeneity can be achieved, and may have an h important rheological control on the dynamics of slip. To test melt homogenization in the frictional melt zones of volcanic conduits we performed constant-rate slip experiments under controlled stress conditions using a high-velocity rotary shear apparatus. Volcanic dome samples from three different volcanoes (Volcán De Colima, Soufrière Hills Volcano and Santiaguito Volcano) were investigated. Each sample was subjected to a stress of 1 MPa and slip rate of 1 m/s. For each sample set 5 experiments were conducted: 1) experiment stopped at the onset of melting; 2) experiment stopped on the formation of a full melt layer; 3) experiment stopped after 5m of slip at steady state conditions; 4) experiment stopped after 10m of slip at steady state conditions; 5) experiment stopped after 15m of slip at steady state conditions. We analyzed the resulting proto-melt zones using micron sized X-ray spectroscopy in the high-brightness synchrotron beamline I18 (at Diamond Light Source UK). Particular focus was given to the concentration variance analysis of Rare Earth Elements as their mobilities can be used to precisely quantify the degree and timescale of homogenisation involved during frictional melting. This study refines our understanding of the chemical process of melting and mixing which carry important consequences for the rheological control on the physical dynamics of slip.

  14. Fabrication of nerve guidance conduit with luminal filler as scaffold for peripheral nerve repair

    International Nuclear Information System (INIS)

    Aranilla, Charito T.; Wach, Rodoslaw; Ulanski, Piotr

    2015-01-01

    Peripheral nerve injury is a serious health concern for society, affecting trauma patients, many of whom acquire life-long disability. The gold standard of treatment for peripheral nerve injury is the use of nerve grafts, wherein nerve autograft or allograft is used to bridge the gap in the damaged nerve. Nerve guidance conduits (NGCs) are an attractive alternative to nerve autografts for aiding in the regeneration of peripheral nerve tissue. NGCs are small cylinders or tubes composed of either natural or synthetic biomaterials that are used to axon regeneration. The ends of the damaged nerve are inserted into either end of the cylinder and the NGC acts both as a connecting bridge for the severed nerve ends as well as a protective shelter for the regenerating nerve. This study aims at fabricating nerve guidance conduits with luminal structure based on synthetic biodegradable and biocompatible polymers such as poly (trimethylene carbonate ) (PTMC), poly (lactic acid) (PLA) and poly (caprolactone) (PCL). Initial base materials for fabrication were PLA acid tubes compared to PCL tubes when prepared by spray and dip-coating methods. The morphology of the tubes where examined by SEM and results showed better porosity of PLA acid tubes compared to PCL tubes when prepared by spraying technique. Poly(lactic acid) was then blended with poly(trimethylene carbonate) at a ratio of 1:4 (5% total polymer content) for further fabrication. Electron beam radiation (25 and 50 kGy) was employed for sterilization and the changes in properties induced by irradiation in comprising polymers were evaluated. The wettability, mechanical thermal properties were not significantly changed by irradiation.In a separate experiment, synthesis of carboxymethyl chitosan hydrogel crosslinked by electron beam radiation was studied to create a luminal filler for PTMC-PLA tubes. Based on proper viscosity of solution before crosslinking, sufficient gel fraction and swelling, 10% w/v concentration of

  15. Pockets, conduits, channels, and plumes: links to volcanism and orogeny in the rollback dominated western Mediterranean

    Science.gov (United States)

    Miller, Meghan S.; Sun, Daoyuan; O'Driscoll, Leland; Becker, Thorsten W.; Holt, Adam; Diaz, Jordi; Thomas, Christine

    2015-04-01

    Detailed mantle and lithospheric structure from the Canary Islands to Iberia have been imaged with data from recent temporary deployments and select permanent stations from over 300 broadband seismometers. The stations extended across Morocco and Spain as part of the PICASSO, IberArray, and Morocco-Münster experiments. We present results from S receiver functions (SRF), shear wave splitting, waveform modeling, and geodynamic models that help constrain the tectonic evolution of the westernmost Mediterranean, including orogenesis of the Atlas Mountains and occurrence of localized alkaline volcanism. Our receiver function images, in agreement with previous geophysical modeling, show that the lithosphere is thin (~65 km) beneath the Atlas, but thickens (~100 km) over a very short length scale at the flanks of the mountains. We find that these dramatic changes in lithospheric thickness also correspond to dramatic decreases in delay times inferred from S and SKS splitting observations of seismic anisotropy. Pockets and conduits of low seismic velocity material below the lithosphere extend along much of the Atlas to Southern Spain and correlate with the locations of Pliocene-Quaternary magmatism. Waveform analysis from the USC linear seismic array across the Atlas Mountains constrains the position, shape, and physical characteristics of one localized, low velocity conduit that extends from the uppermost mantle (~200 km depth) up to the volcanoes in the Middle Atlas. The shape, position and temperature of these seismically imaged low velocity anomalies, topography of the base of the lithosphere, morphology of the subducted slab beneath the Alboran Sea, position of the West African Craton and correlation with mantle flow inferred from shear wave splitting suggest that the unusually high topography of the Atlas Mountains and isolated recent volcanics are due to active mantle support that may be from material channeled from the Canary Island plume.

  16. Radial Artery as a Coronary Artery Bypass Conduit: 20-Year Results.

    Science.gov (United States)

    Gaudino, Mario; Tondi, Paolo; Benedetto, Umberto; Milazzo, Valentina; Flore, Roberto; Glieca, Franco; Ponziani, Francesca Romana; Luciani, Nicola; Girardi, Leonard N; Crea, Filippo; Massetti, Massimo

    2016-08-09

    There is a lack of evidence for the choice of the second conduit in coronary surgery. The radial artery (RA) is a possible option, but few data on very-long-term outcomes exist. This study describes 20-year results of RA grafts used for coronary artery bypass grafting and the effects of RA removal on forearm circulation. We report the results of the prospective 20-year follow-up of the first 100 consecutive patients who received the RA as a coronary bypass conduit at our institution. Follow-up was 100% complete. There were 64 deaths, 23 (35.9%) from cardiovascular causes. Kaplan-Meier 20-year survival was 31%. Of the 36 survivors, 33 (91.6%) underwent RA graft control at a mean of 19.0 ± 2.5 years after surgery. The RA was found to be patent in 24 cases (84.8% patency). In the overall population, probability of graft failure at 20 years was 19.0 ± 0.2% for the left internal thoracic artery (ITA), 25.0 ± 0.2% for the RA, and 55.0 ± 0.2% for the saphenous vein (p = 0.002 for RA vs. saphenous vein, 0.11 for RA vs. ITA, and p 90%, but not location of distal anastomosis, significantly influenced long-term RA graft patency. No patients reported hand or forearm symptoms. The ulnar artery diameter was increased in the operated arm (2.44 ± 0.43 mm vs. 2.01 ± 0.47 mm; p 90% stenosis. RA harvesting does not lead to hand or forearm symptoms, even at a very-long-term follow-up. Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  17. Theory and modelling of quench in cable-in-conduit superconducting magnets

    International Nuclear Information System (INIS)

    Shajii, A.

    1994-04-01

    A new simple, self consistent theoretical model is presented that describes the phenomena of quench propagation in Cable-In-Conduit superconducting magnets. The model (Quencher) circumvents many of the difficulties associated with obtaining numerical solutions in more general existing models. Specifically, a factor of 30-50 is gained in CPU time over the general, explicit time dependent codes used to study typical quench events. The corresponding numerical implementation of the new model is described and the numerical results are shown to agree very well with those of the more general models, as well as with experimental data. Further, well justified approximations lead to the MacQuench model that is shown to be very accurate and considerably more efficient than the Quencher model. The MacQuench code is suitable for performing quench studies on a personal computer, requiring only several minutes of CPU time. In order to perform parametric studies on new conductor designs it is required to utilize a model such as MacQuench because of the high computational efficiency of this model. Finally, a set of analytic solutions for the problem of quench propagation in Cable-In-Conduit Conductors is presented. These analytic solutions represent the first such results that remain valid for the long time scales of interest during a quench process. The assumptions and the resulting simplifications that lead to the analytic solutions are discussed, and the regimes of validity of the various approximations are specified. The predictions of the analytic results are shown to be in very good agreement with numerical as well as experimental results. Important analytic scaling relations are verified by such comparisons, and the consequences of some of these scalings on currently designed superconducting magnets are discussed

  18. Tissue-engineered spiral nerve guidance conduit for peripheral nerve regeneration.

    Science.gov (United States)

    Chang, Wei; Shah, Munish B; Lee, Paul; Yu, Xiaojun

    2018-06-01

    Recently in peripheral nerve regeneration, preclinical studies have shown that the use of nerve guidance conduits (NGCs) with multiple longitudinally channels and intra-luminal topography enhance the functional outcomes when bridging a nerve gap caused by traumatic injury. These features not only provide guidance cues for regenerating nerve, but also become the essential approaches for developing a novel NGC. In this study, a novel spiral NGC with aligned nanofibers and wrapped with an outer nanofibrous tube was first developed and investigated. Using the common rat sciatic 10-mm nerve defect model, the in vivo study showed that a novel spiral NGC (with and without inner nanofibers) increased the successful rate of nerve regeneration after 6 weeks recovery. Substantial improvements in nerve regeneration were achieved by combining the spiral NGC with inner nanofibers and outer nanofibrous tube, based on the results of walking track analysis, electrophysiology, nerve histological assessment, and gastrocnemius muscle measurement. This demonstrated that the novel spiral NGC with inner aligned nanofibers and wrapped with an outer nanofibrous tube provided a better environment for peripheral nerve regeneration than standard tubular NGCs. Results from this study will benefit for future NGC design to optimize tissue-engineering strategies for peripheral nerve regeneration. We developed a novel spiral nerve guidance conduit (NGC) with coated aligned nanofibers. The spiral structure increases surface area by 4.5 fold relative to a tubular NGC. Furthermore, the aligned nanofibers was coated on the spiral walls, providing cues for guiding neurite extension. Finally, the outside of spiral NGC was wrapped with randomly nanofibers to enhance mechanical strength that can stabilize the spiral NGC. Our nerve histological data have shown that the spiral NGC had 50% more myelinated axons than a tubular structure for nerve regeneration across a 10 mm gap in a rat sciatic nerve

  19. Aptitude visuelle à la conduite automobile: exemple des candidats au permis de conduire à Libreville

    Science.gov (United States)

    Souhail, Hassane; Assoumou, Prudence; Birinda, Hilda; Mengome, Emmanuel Mve

    2015-01-01

    L'objectif était d’évaluer l'aptitude visuelle à la conduite automobile des candidats au permis de conduire à Libreville. Il s'agissait d'une étude transversale, descriptive et analytique, qui s'est déroulée à Libreville pendant la période du 4 avril 2012 au 14 juillet 2012 (soit 4 mois et 10 jours). La population d’étude concernait les candidats soumis aux épreuves d'obtention du permis de conduire. Nous avons inclus dans notre travail, les candidats, ayant donné leur consentement par écrit et exclus ceux refusant d'adhérer à l'enquête. Les variables étudiées concernaient l’âge, le sexe, la population d’étude, l'activité professionnelle, l'acuité visuelle de loin et de près, la vision des couleurs, la catégorie du permis de conduire, et l'aptitude visuelle à la conduite automobile. La saisie et l'analyse des données ont été collectées au moyen d'une fiche d'enquête standardisée; après vérification et validation, elles ont été saisies sur le logiciel Excel Windows et analysées sur le logiciel Epi Info version 3.5.1. L’âge moyen des 406 candidats était de 29 ans ± 6,65 ans avec des extrêmes allant de 17 ans à 52 ans. Les hommes représentaient 283 (69,7%) et les femmes 123 (30,3%), soit un ratio de 2,3. Les fonctionnaires étaient retrouvés dans 39,4 % des cas, suivi des élèves-étudiants dans 33,5%. Dans notre population d’étude, 71 sur 406 candidats avaient une baisse de l'acuité visuelle de loin, soit 17,5%. Dans notre série, nous avons retrouvés 34 candidats âgés de 40 ans et plus, et seulement 14 candidats (41,2%) avaient une baisse de l'acuité visuelle de près. La quasi-totalité des patients avaient une vision de couleurs normale (99,5%), cependant 2 candidats avaient une vision de couleurs anormale, soit une prévalence de 0,5%. Dans notre échantillon, 403 (99,3%) sollicitaient un permis de conduire de catégorie léger (perms A, A1, B, F) et 3 (0,7%) sollicitaient un permis de conduire de type

  20. Vom Fachwissen zur Handlungskompetenz - die Berufsschule vor den Herausforderungen des sozioökonomischen Strukturwandels

    OpenAIRE

    Kouli, Ekaterina

    2006-01-01

    Der sozioökonomische Wandel und die damit einhergehenden Veränderungen der Wirtschafts- und Beschäftigungsstrukturen stellen das Bildungssystem in Deutschland vor neuartige Herausforderungen. Wesentliche Momente dieses Wandels sind die technologische Entwicklung, die Globalisierung der Wirtschaft, der Übergang von der Industrie- zur Wissensgesellschaft sowie Veränderungen in den gesellschaftlichen Wertvorstellungen. Diese Entwicklungen verändern die Arbeitsprozesse in den Unternehmen und dami...

  1. Ausbau der ganztägigen Kindertagesbetreuung kann zur Zufriedenheit von Müttern beitragen

    OpenAIRE

    Stahl, Juliane F.; Schober, Pia S.

    2016-01-01

    Eltern mit Kindern, die noch nicht zur Schule gehen, stehen bei der Vereinbarkeit von Familie und Beruf vor besonderen Herausforderungen. Um diese Eltern besser zu unterstützen, hat die Politik sowohl den Ausbau von Plätzen in der öffentlichen Kindertagesbetreuung (Kita) forciert als auch ein bedarfsorientiertes Angebot an Ganztagsplätzen gesetzlich verankert. Der vorliegende Beitrag untersucht auf Basis von Daten des Sozio-oekonomischen Panels (SOEP) und der Stichprobe 'Familien in Deutschla...

  2. Beiträge zur Beugungstheorie elektromagnetischer Wellen an Kanten vollkommen leitender Flächen

    OpenAIRE

    Zinal, Sherko

    2011-01-01

    Den Kern der vorliegenden Arbeit bilden die Untersuchung sowie die Formulierung von Lösungsansätzen für ein elementares, elektromagnetisches Beugungsproblem; einer undendlich langen Schlitzleitung mit einseitig begrenzter etallisierungsplatte (Abschnitt 1.2). Motiviert wird dieses Beugungsproblem im Hinblick auf die Beugungsproblematik planarer Strahler (Antennen) mit endlich ausgedehnter Grundmetallisierung (Abschnitt 1.1). In Kapitel 2 wird ein Stromlinien-Modell zur Formulierung des Beugun...

  3. Ein praxisorientierter empirischer Ansatz zur Bestimmung des Ausfallverhaltens konventioneller Bremssysteme in Personenkraftwagen

    OpenAIRE

    Althaus, Dirk

    2009-01-01

    Der Funktionsumfang im Kraftfahrzeug nimmt bekanntlich stetig zu. Neben vollständig neu entwickelten Systemen werden aber auch bestehende durch zusätzliche Funktionen erweitert. Besonders für Sicherheitssysteme kann dies weitreichende Folgen haben, da solche Mehrbelastungen nicht nur zur Minderung der Zuverlässigkeit beitragen können, sondern evtl. auch die Sicherheit herabsetzen. Durch die steigende Vernetzung der Systeme und Komponenten untereinander ist es darüber hinaus nicht mehr aus...

  4. Aufbau humaner 3D-in-vitro-Testsysteme zur Risikobewertung von Nanomaterialien

    OpenAIRE

    Hampel, Martina

    2009-01-01

    Die Nanotechnologie stellt eine der Schlüsseltechnologien dieses Jahrhunderts dar Parallel zur Erschließung neuer Möglichkeiten, die die Nanotechnologie bietet, müssen jedoch auch mögliche Risiken untersucht werden. Die dabei zurzeit noch am häufigsten eingesetzte Untersuchungsmethode von Nanopartikeln ist die Verwendung zweidimensionaler in vitro Zellkulturen. Zum Einsatz kommen hier jedoch meist Zelllinien. Die Versuchsansätze entsprechen damit nicht den Bedingungen im menschlichen Körper. ...

  5. Ergebnisse einer empirischen Untersuchung zur Klangfarbenwahmehmung von Vorschulkindern mit einem Klangmemory

    OpenAIRE

    Schellberg, Gabriele

    1998-01-01

    Im Unterschied zu anderen Bereichen der musikalischen Wahrnehmung gibt es zur Klangfarbenwahmehmung nur wenige Untersuchungen. Ein Grund dafür dürfte in den methodischen Schwierigkeiten liegen, die insbesondere bei der Untersuchung kleiner Kinder auftreten. Ein Klangfarbentest für Vorschulkinder existiert bislang nicht. Daher wurde nach mehreren Voruntersuchungen ein „Klangfarben-Memory“ als Methode entwickelt und bei Vorschulkindern eingesetzt. Die Ergebnisse dieser empirischen Studie werden...

  6. Implementierung, Evaluation und vergleichende Untersuchungen des Powerplex 16 Systems zur quantitativen Chimärismusanalyse

    OpenAIRE

    Joachim, Stefanie

    2010-01-01

    Die allogene Stammzelltransplantation ist ein Verfahren zur Therapie verschiedener maligner und nicht-maligner hämatologischer Erkrankungen. Da es sich um eine sehr aufwendige Therapie handelt, sind Methoden, die den Behandlungsverlauf dokumentieren, wie minimale Resterkrankung und Chimärismusanalyse, essentiell. Eine nach Stammzelltransplantation vollständig vom Spender abgeleitete Hämatopoese ist Voraussetzung für das Engraftment und die Prophylaxe eines Rezidivs der zugrundeliegenden Er...

  7. Isolation und Charakterisierung retroviraler Partikel und Proteine zur Untersuchung immunsuppressiver Effekte

    OpenAIRE

    Pietsch, Heiko

    2016-01-01

    Obgleich auf dem Gebiet der Transplantationsmedizin in jüngster Zeit beachtliche Fortschritte erzielt worden sind, ist der Mangel an Organspendern ein fortbestehendes Problem. Im Rahmen der Xenotransplantation können Schweine als Spender zur Transplantation von Zellen oder Organen beim Menschen dienen. Um die Sicherheit der Xenotransplantation zu gewährleisten, ist sowohl die Entwicklung sensitiver Nachweismethoden als auch die Einschätzung des Gefahrenpotentials durch eine Infektion für den ...

  8. Sprache als Schlüssel zur Welt: Bibliotheken und Sprach-Kitas in guter Partnerschaft

    OpenAIRE

    Susanne Brandt

    2017-01-01

    Von 2016 bis voraussichtlich 2020 wird durch das Bundesministerium für Familie, Senioren, Frauen und Jugend das Bundesprogramm „Sprach-Kitas. Weil Sprache der Schlüssel zur Welt ist“ gefördert. Es richtet sich an Kindertageseinrichtungen, die von einem überdurchschnittlich hohen Anteil von Kindern mit besonderem Bedarf an sprachlicher Bildung und Förderung besucht werden. Dabei stehen besonders die folgenden drei Zielbereiche im Fokus: alltagsintegrierte sprachliche Bildung, inklusive Bildung...

  9. Erstellung einer Checkliste zur Beurteilung des Arbeitsplatzes eines Physiotherapeuten nach ergonomischen Gesichtspunkten

    OpenAIRE

    Gauermann, Christoph

    2013-01-01

    Einleitung: Arbeitsbedingte Erkrankungen des Muskel-Skelett-Systems sind unter Physiotherapeuten sehr häufig. Die präventive Forschung hat diese Berufsgruppe bisher kaum untersucht. In diesem Zusammenhang stellt die Veränderung des Arbeitsumfeldes einen vielversprechenden Ansatz für die Verhinderung arbeitsbedingter Erkrankungen dar. Das Ziel dieser Arbeit ist die Erstellung einer Checkliste zur Bewertung des Arbeitsplatzes eines Physiotherapeuten zu erstellen. Material und Methoden: ...

  10. Entwicklung und Anwendung von Methoden zur Bestimmung von Selen-Spezies in human-biologischem Material

    OpenAIRE

    Jäger, Thomas

    2014-01-01

    Selen ist essentieller Bestandteil von mehr als 25 physiologisch wichtigen menschlichen Enzymen. Der tägliche Bedarf wird überwiegend in Form von organischen Selenverbindungen wie Selenmethionin oder Selenocystein aus der Nahrung aufgenommen. Weitere Expositionswege sind die Einnahme von Nahrungsergänzungsmitteln zur Selensupplementation sowie die inhalative oder dermale Aufnahme von in erster Linie anorganischen Selenverbindungen oder elementarem Selen an Arbeitsplätzen der Selen-verarbeiten...

  11. Bildgebendes Multispektralsystem zur Serienfarbmessung an goniochromatischen Oberflächenbeschichtungen in der Automobil- und Zulieferindustrie

    OpenAIRE

    Jäger, Stefan

    2006-01-01

    In dieser Arbeit wird ein multispektrales bildgebendes System zur Farbmessung von Metall- und Perleffektlacken in einem industriellen Umfeld vorgestellt. Der Zweck des vorgeschlagenen Systems ist die Serienüberwachung und daraus folgend, die Steuerung von Lackierprozessen in der Automobil- und Zulieferindustrie, um das Qualitätsniveau anzuheben und Kosten zu reduzieren. Ausgehend von der Analyse der messtechnischen Anforderungen und den durch die Prozesstechnik gegebenen Randbedingungen wurde...

  12. New facade concepts ranging from statics to dynamics; Neue Fassadenkonzepte. Von der Statik zur Dynamik

    Energy Technology Data Exchange (ETDEWEB)

    Kranz, H.R. [Siemens AG, Karlsruhe (Germany)

    1995-12-31

    In chapter 9 of the anthology about building control new facade concepts are presented, including new facade technologies, conductivity of new facade concepts and combination of new technologies. The whole complex ranging from statics to dynamics is explained. (BWI) [Deutsch] Kapitel 9 des Sammelbandes ueber Building Control stellt neue Fassadenkonzepte vor: Neue Fassadentechnologien, Leitfunktionen neuer Fassadenkonzepte, Kombination neuer Technologien. In diesem Zusammenhang wird der gesamte Komplex von der Statik bis zur Dynamik behandelt. (BWI)

  13. Entwicklung von Cysteinproteaseinhibitoren - ein klassischer und ein kombinatorischer Ansatz zur Inhibitoroptimierung

    OpenAIRE

    Machon, Uwe Rainer

    2009-01-01

    Ziel der Dissertation „Entwicklung von Cysteinproteaseinhibitoren – ein klassischer und ein kombinatorischer Ansatz zur Inhibitoroptimierung“ war die Optimierung von neuen Inhibitoren von Falcipain-2 und Rhodesain als neue potentielle Wirkstoffe gegen Malaria bzw. die Schlafkrankheit über zwei verschiedene Methoden. Es handelt sich hierbei um einen klassischen und einen kombinatorischen Ansatz. Der klassische Ansatz basiert auf einer Struktur, deren Aktivität per Zufall entdeckt wurde. In Scr...

  14. The effect on stability and thermal hydraulic quenchback of perforating the jacket of a cable-in-conduit conductor

    International Nuclear Information System (INIS)

    Dresner, L.

    1994-01-01

    This Paper continues earlier work on the reduction of the quench pressure in a doubler cable-in-conduit conductor achieved by perforating the inner jacket. The present study examines the effect of the perforations on the stability margin and on the ononset of thermal hydraulic quenchback

  15. Terrestrial analogs to lunar sinuous rilles - Kauhako Crater and channel, Kalaupapa, Molokai, and other Hawaiian lava conduit systems

    International Nuclear Information System (INIS)

    Coombs, C.R.; Hawke, B.R.; Wilson, L.

    1990-01-01

    Two source vents, one explosive and one effusive erupted to form a cinder cone and low lava shield that together compose the Kalaupapa peninsula of Molokai, Hawaii, A 50-100-m-wide channel/tube system extends 2.3 km northward from kauhako crater in the center of the shield. Based on modeling, a volume of up to about 0.2 cu km of lava erupted at a rate of 260 cu m/sec to flow through the Kauhako conduit system in one of the last eruptive episodes on the peninsula. Channel downcutting by thermal erosion occurred at a rate of about 10 micron/sec to help form the 30-m-deep conduit. Two smaller, secondary tube systems formed east of the main lava channel/tube. Several other lava conduit systems on the islands of Oahu and Hawaii were also compared to the Kauhako and lunar sinuous rille systems. These other lava conduits include Whittington, Kupaianaha, and Mauna Ulu lava tubes. Morphologically, the Hawaiian tube systems studied are very similar to lunar sinuous rilles in that they have deep head craters, sinuous channels, and gentle slopes. Thermal erosion is postulated to be an important factor in the formation of these terrestrial channel systems and by analogy is inferred to be an important process involved in the formation of lunar sinuous rilles. 28 refs

  16. Fast evolving conduits in clay-bonded sandstone: Characterization, erosion processes and significance for the origin of sandstone landforms

    Czech Academy of Sciences Publication Activity Database

    Bruthans, J.; Svetlik, D.; Soukup, J.; Schweigstillová, Jana; Válek, Jan; Sedláčková, M.; Mayo, A.L.

    2012-01-01

    Roč. 177, December (2012), s. 178-193 ISSN 0169-555X R&D Projects: GA AV ČR IAA300130806 Institutional support: RVO:67985891 ; RVO:68378297 Keywords : sandstone * erosion * piping * tensile strength * conduit * landform Subject RIV: DA - Hydrology ; Limnology Impact factor: 2.552, year: 2012

  17. Inactive supply wells as conduits for flow and contaminant migration: conditions of occurrence and suggestions for management

    Science.gov (United States)

    Gailey, Robert M.

    2017-11-01

    Water supply wells can act as conduits for vertical flow and contaminant migration between water-bearing strata under common hydrogeologic and well construction conditions. While recognized by some for decades, there is little published data on the magnitude of flows and extent of resulting water quality impacts. Consequently, the issue may not be acknowledged widely enough and the need for better management persists. This is especially true for unconsolidated alluvial groundwater basins that are hydrologically stressed by agricultural activities. Theoretical and practical considerations indicate that significant water volumes can migrate vertically through wells. The flow is often downward, with shallow groundwater, usually poorer in quality, migrating through conduit wells to degrade deeper water quality. Field data from locations in California, USA, are presented in combination with modeling results to illustrate both the prevalence of conditions conducive to intraborehole flow and the resulting impacts to water quality. Suggestions for management of planned wells include better enforcement of current regulations and more detailed consideration of hydrogeologic conditions during design and installation. A potentially greater management challenge is presented by the large number of existing wells. Monitoring for evidence of conduit flow and solute transport in areas of high well density is recommended to identify wells that pose greater risks to water quality. Conduit wells that are discovered may be addressed through approaches that include structural modification and changes in operations.

  18. Dual-Component Gelatinous Peptide/Reactive Oligomer Formulations as Conduit Material and Luminal Filler for Peripheral Nerve Regeneration.

    Science.gov (United States)

    Kohn-Polster, Caroline; Bhatnagar, Divya; Woloszyn, Derek J; Richtmyer, Matthew; Starke, Annett; Springwald, Alexandra H; Franz, Sandra; Schulz-Siegmund, Michaela; Kaplan, Hilton M; Kohn, Joachim; Hacker, Michael C

    2017-05-21

    Toward the next generation of nerve guidance conduits (NGCs), novel biomaterials and functionalization concepts are required to address clinical demands in peripheral nerve regeneration (PNR). As a biological polymer with bioactive motifs, gelatinous peptides are promising building blocks. In combination with an anhydride-containing oligomer, a dual-component hydrogel system (cGEL) was established. First, hollow cGEL tubes were fabricated by a continuous dosing and templating process. Conduits were characterized concerning their mechanical strength, in vitro and in vivo degradation and biocompatibility. Second, cGEL was reformulated as injectable shear thinning filler for established NGCs, here tyrosine-derived polycarbonate-based braided conduits. Thereby, the formulation contained the small molecule LM11A-31. The biofunctionalized cGEL filler was assessed regarding building block integration, mechanical properties, in vitro cytotoxicity, and growth permissive effects on human adipose tissue-derived stem cells. A positive in vitro evaluation motivated further application of the filler material in a sciatic nerve defect. Compared to the empty conduit and pristine cGEL, the functionalization performed superior, though the autologous nerve graft remains the gold standard. In conclusion, LM11A-31 functionalized cGEL filler with extracellular matrix (ECM)-like characteristics and specific biochemical cues holds great potential to support PNR.

  19. A 40 kA NbTi cable in conduit conductor for the large poloidal field coils of net

    International Nuclear Information System (INIS)

    Torossian, A.; Bessette, D.; Turck, B.; Kazimierzak, B.

    1990-01-01

    The main feature of this cable in conduit design is to separate the manufacture of the full length of the steel conduit (400 m) and of the cable in order to minimize the industrial risk and consequently the cost. A circular cross section for that cable seems to be the most suitable for that purpose: - axisymmetric cabling with full transposition of strands, - cable behaviour independent of the field orientation, - less deformation of subcables, - cross section remains circular when the cable is under tension and makes the slippage of the cable in the conduit easier, - butt welding of 8 m long tubes forming the conduit becomes simpler. The square external shape allows to minimize the amount of insulating material and consequently improves the overall current density of the coil. This conductor is aimed to large poloidal field coils for NET which do not require high field and in that case NbTi seems to be the best choice with regard to reliability and cost but Nb 3 Sn could be used as well. Stainless steel ribbons are inserted between subcables in order to reduce losses induced by the rapid field changes and also to improve the mechanical behaviour of the cable

  20. FATIGUE PROPERTIES OF MODIFIED 316LN STAINLESS STEEL AT 4 K FOR HIGH FIELD CABLE-IN-CONDUIT APPLICATIONS

    International Nuclear Information System (INIS)

    Toplosky, V. J.; Walsh, R. P.; Han, K.

    2010-01-01

    Cable-In-Conduit-Conductor (CICC) alloys, exposed to Nb 3 Sn reaction heat-treatments, such as modified 316LN require a design specific database. A lack of fatigue life data (S-n curves) that could be applied in the design of the ITER CS and the NHMFL Series Connected Hybrid magnets is the impetus for the research presented here. The modified 316LN is distinguished by a lower carbon content and higher nitrogen content when compared to conventional 316LN. Because the interstitial alloying elements affect the mechanical properties significantly, it is necessary to characterize this alloy in a systematic way. In conjunction, to ensure magnet reliability and performance, several criteria and expectations must be met, including: high fatigue life at the operating stresses, optimal stress management at cryogenic temperatures and thin walled conduit to reduce coil mass. Tension-tension load control axial fatigue tests have good applicability to CICC solenoid magnet design, thus a series of 4 K strength versus fatigue life curves have been generated. In-situ samples of 316LN base metal, seam welded, butt welded and seam plus butt welded are removed directly from the conduit in order to address base and weld material fatigue life variability. The more than 30 fatigue tests show good grouping on the fatigue life curve and allow discretionary 4 K fatigue life predictions for conduit made with modified 316LN.

  1. Konkurrenz oder Kooperation? Zur Entwicklung des Verhältnisses von Medienbildung und informatischer Bildung

    Directory of Open Access Journals (Sweden)

    Gerhard Tulodziecki

    2016-10-01

    Full Text Available Mit der gegenwärtigen Diskussion um Mediatisierung und Digitalisierung ist die Forderung verbunden, der Medienbildung und/oder der informatischen Bildung ein größeres Gewicht in der schulischen Bildung zu verschaffen. Dies legt die Frage nahe, wie ein produktives Verhältnis zwischen beiden gestaltet werden sollte und wie beide am besten zu einer zeitgemäßen Bildung beitragen können. Bei entsprechenden Überlegungen spielen unter anderem Entwicklungen eine Rolle, die sich seit frühen Forderungen nach einer Computerbildung im Verhältnis zur damaligen Medienerziehung herausgebildet haben. In dem vorliegenden Beitrag werden solche Entwicklungen skizziert und Schlussfolgerungen für die gegenwärtige Diskussion formuliert. Dabei kommen unterschiedliche Auffassungen zur bildungsbezogenen Auseinandersetzung mit Medien sowie mit Informations- und Kommunikationstechnologien in den Blick. Für das Verhältnis von Medienbildung und informatischer Bildung ergibt sich als zentrale Schlussfolgerung, dass sowohl eine Integration der informatischen Bildung in die Medienbildung als auch eine umgekehrte Lösung unangemessen erscheint, wiewohl beide Bereiche auf Anteile aus dem jeweils anderen Bereich angewiesen sind. Danach werden für eine Medienbildung mit informatischen Anteilen ein geeigneter Medienbegriff und eine tragfähige Bildungsauffassung sowie ein Ansatz zu einem inhaltlich-thematischen Kompetenzrahmen beschrieben. Überlegungen zur schulischen Umsetzung schließen den Beitrag ab.

  2. Neuere Untersuchungen zur Prädiktion von EEG-Signalen bei Epilepsie

    Directory of Open Access Journals (Sweden)

    C. Niederhöfer

    2007-06-01

    Full Text Available Seit einigen Jahren ist die Analyse von EEG-Signalen bei Epilepsie Gegenstand zahlreicher wissenschaftlicher Arbeiten; Zielvorstellung ist dabei die Entwicklung von Verfahren zur Erkennung eines möglichen Voranfallszustandes. Im Vordergrund steht beispielsweise die Approximation einer so genannten effektiven Korrelationsdimension, die Bestimmung der maximalen Lyapunov-Exponenten, Detektionsverfahren für Muster bei Zellularen Nichtlinearen Netzwerken, die Bestimmung der mittleren Phasenkohärenz und Verfahren zur nichtlinearen Prädiktion von EEG-Signalen. Trotz umfangreicher Bemühungen kann bis heute eine Erkennung von Anfallsvorboten mit einer Sensitivität und Spezifität, die eine automatisierte Anfallsvorhersage ermöglichen würde, noch nicht durchgeführt werden. In diesem Beitrag werden neue Ergebnisse zur Prädiktion von EEG-Signalen bei Epilepsie vorgestellt. Dabei werden Signale, welche mittels intrakranieller electrocorticographischer (ECoG und stereoelectroencephalographischer (SEEG Ableitungen registriert wurden, segmentweise analysiert. Unter der Annahme, dass sich Änderungen des Systems ,,Gehirn" als Änderungen im Prädiktor, d.h. in seinen Systemparametern widerspiegeln, könnte eine nähere Betrachtung der Prädiktoreigenschaften zu einer Erkennung von Anfallsvorboten führen.

  3. Long-Term Regeneration and Functional Recovery of a 15 mm Critical Nerve Gap Bridged by Tremella fuciformis Polysaccharide-Immobilized Polylactide Conduits

    Directory of Open Access Journals (Sweden)

    Shan-hui Hsu

    2013-01-01

    Full Text Available Novel peripheral nerve conduits containing the negatively charged Tremella fuciformis polysaccharide (TF were prepared, and their efficacy in bridging a critical nerve gap was evaluated. The conduits were made of poly(D,L-lactide (PLA with asymmetric microporous structure. TF was immobilized on the lumen surface of the nerve conduits after open air plasma activation. The TF-modified surface was characterized by the attenuated total reflection Fourier-transformed infrared spectroscopy and the scanning electron microscopy. TF modification was found to enhance the neurotrophic gene expression of C6 glioma cells in vitro. TF-modified PLA nerve conduits were tested for their ability to bridge a 15 mm gap of rat sciatic nerve. Nerve regeneration was monitored by the magnetic resonance imaging. Results showed that TF immobilization promoted the nerve connection in 6 weeks. The functional recovery in animals receiving TF-immobilized conduits was greater than in those receiving the bare conduits during an 8-month period. The degree of functional recovery reached ~90% after 8 months in the group of TF-immobilized conduits.

  4. Fabrication of bioactive conduits containing the fibroblast growth factor 1 and neural stem cells for peripheral nerve regeneration across a 15 mm critical gap

    International Nuclear Information System (INIS)

    Ni, Hsiao-Chiang; Tseng, Ting-Chen; Hsu, Shan-hui; Chen, Jeng-Rung; Chiu, Ing-Ming

    2013-01-01

    Nerve conduits are often used in combination with bioactive molecules and stem cells to enhance peripheral nerve regeneration. In this study, the acidic fibroblast growth factor 1 (FGF1) was immobilized onto the microporous/micropatterned poly (D, L-lactic acid) (PLA) nerve conduits after open air plasma treatment. PLA substrates grafted with chitosan in the presence of a small amount of gold nanoparticles (nano Au) showed a protective effect on the activity of the immobilized FGF1 in vitro. Different conduits were tested for their ability to bridge a 15 mm critical gap defect in a rat sciatic nerve injury model. Axon regeneration and functional recovery were evaluated by histology, walking track analysis and electrophysiology. Among different conduits, PLA conduits grafted with chitosan–nano Au and the FGF1 after plasma activation had the greatest regeneration capacity and functional recovery in the experimental animals. When the above conduit was seeded with aligned neural stem cells, the efficacy was further enhanced and it approached that of the autograft group. This work suggested that microporous/micropatterned nerve conduits containing bioactive growth factors may be successfully fabricated by micropatterning techniques, open plasma activation, and immobilization, which, combined with aligned stem cells, may synergistically contribute to the regeneration of the severely damaged peripheral nerve. (paper)

  5. Beitraege zur Astronomiegeschichte, Band 5 (Acta Historica Astronomiae Vol. 18)

    Science.gov (United States)

    Duerbeck, H. W.; Dick, W. R.; Hamel, J.

    2003-01-01

    The 18th volume of the Acta Historica Astronomiae is at the same time the sixth collection of essays on the history of astronomy ("Beitræge zur Astronomiegeschichte, Band 6"), edited by the historians of astronomy W.R. Dick (Potsdam) and J. Hamel (Berlin). Besides a few short notices and book reviews, the book contains eight major articles, which deal with astronomical topics covering the time from the 16th to the 19th centuries. The first article by Michael Weichenhan (Berlin) deals with "the invention of the disk-shaped earth: a chapter of Copernican apologetics". The author shows that the concept of a "disc-shaped Earth" was by no means widespread in the middle ages, but restricted to the father of the church Lactantius and some adherents. Nevertheless, it was used by adherents of Copernicus to show the absurd consequences of a strictly literal biblical interpretation -- here concerning the Earth's shape, disc versus sphere, there the geocentric versus the heliocentric system. This thorough philosophical study is followed by two very short articles. "The measuring accuracy of Tycho's large sextant" by Johann Wünsch investigates O-C values of planet-star distances, as based on Tycho's observations as published in the Historia Coelestis (a compilation, which is also based on Tycho's manuscripts, and published in Regensburg in 1672). The result is that standard deviations are 80 arcseconds for Saturn and 89 arcseconds for Jupiter and Mars, an unexpectedly poor result in view of the general opinion that Tycho was famous for his precision work. "The astronomer Christoph Grienberger and the Galilei trial" by Franz Daxecker deals with a Jesuit astronomer who was both the disciple and successor of the mathematician-astronomer Christopher Clavius at the Collegium Romanum. While he was inclined to Galilei early on, he was forced to propagate Aristotelian doctrine. The brief article is very concise, but extremely tiresome to read (3 pages of pure text are embellished by

  6. Experimental composite guidance conduits for peripheral nerve repair: An evaluation of ion release

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, X.F. [Department of Biological Sciences and Medical Engineering Design and Innovation Centre, Cork Institute of Technology, Cork (Ireland); Coughlan, A. [Inamori School of Engineering, Alfred University, Alfred, NY. 14802 (United States); O' Shea, H. [Department of Biological Sciences and Medical Engineering Design and Innovation Centre, Cork Institute of Technology, Cork (Ireland); Towler, M.R. [Inamori School of Engineering, Alfred University, Alfred, NY. 14802 (United States); Kehoe, S., E-mail: sharonkehoe@dal.ca [Department of Applied Oral Sciences, Dalhousie University, Halifax, NS, B3H 4R2 (Canada); School of Biomedical Engineering, Dalhousie University, Halifax, NS, B3H 4R2 (Canada); Boyd, D., E-mail: d.boyd@dal.ca [Department of Applied Oral Sciences, Dalhousie University, Halifax, NS, B3H 4R2 (Canada); School of Biomedical Engineering, Dalhousie University, Halifax, NS, B3H 4R2 (Canada)

    2012-08-01

    Poly (lactide-co-glycolide) (PLGA) - Pluronic F127 - glass composites have demonstrated excellent potential, from the perspective of controlled mechanical properties and cytocompatibility, for peripheral nerve regeneration. In addition to controlling the mechanical properties and cytotoxicity for such composite devices, the glass component may mediate specific responses upon implantation via degradation in the physiological environment and release of constituent elements. However, research focused on quantifying the release levels of such therapeutic ions from these experimental medical devices has been limited. To redress the balance, this paper explores the ion release profiles for Si{sup 4+}, Ca{sup 2+}, Na{sup +}, Zn{sup 2+}, and Ce{sup 4+} from experimental composite nerve guidance conduits (CNGC) comprising PLGA (at 12.5, and 20 wt.%), F127 (at 0, 2.5 and 5 wt.%) and various loadings of Si-Ca-Na-Zn-Ce glass (at 20 and 40 wt.%) for incubation periods of up to 28 days. The concentration of each ion, at various time points, was determined using Inductively Coupled Plasma-Atomic Emission Spectrometry (Perkin Elmer Optima 3000). It was observed that the Si{sup 4+}, Na{sup +}, Ca{sup 2+}, Zn{sup 2+} release from CNGCs in this study ranged from 0.22 to 6.477 ppm, 2.307 to 3.277 ppm, 40 to 119 ppm, and 45 to 51 ppm, respectively. The Ce{sup 4+} concentrations were under the minimum detection limits for the ICP instrument utilized. The results indicate that the ion release levels may be appropriate to mediate therapeutic effects with respect to peripheral nerve regeneration. The data generated in this paper provides requisite evidence to optimize composition for pre-clinical evaluation of the experimental composite. - Graphical abstract: Highlights: Black-Right-Pointing-Pointer Time-dependent degradation studies of PLGA/glass composite nerve guidance conduits (NGCs). Black-Right-Pointing-Pointer Si{sup 4+}, Na{sup +}, Ca{sup 2+} and Zn{sup 2+} release levels for the

  7. Medienkompetenz und E-Portfolios für die Sekundarstufe I – ein Weg zur Medienbildung

    Directory of Open Access Journals (Sweden)

    Bernhard Ertl

    2015-06-01

    Full Text Available Medienkompetenz und digital literacy gehören inzwischen zu den Schlüsselkompetenzen und sind ein Teil der Medienbildung von Kindern und Jugendlichen. Medienbildung und/oder die dazu gehörigen Kompetenzen werden jedoch in Lehrplänen oft unterschiedlich verortet und definiert. Hierbei stellt sich die Frage, inwieweit kompetenzorientiertes Lernen den Ansprüchen an Medienbildung gerecht wird bzw. zur Medienbildung beitragen kann. Das Projekt EUfolio implementiert E-Portfolios in verschiedenen europäischen Klassen der Sekundarstufe I und realisiert dabei einen integrativen, fächerübergreifenden Ansatz. Dieser zielt primär auf den Erwerb von Schlüsselqualifikationen, kann jedoch implizit, etwa im Rahmen des reflektierenden Lernens mit E-Portfolios, zur Medienbildung beitragen. Der Artikel charakterisiert die Konzepte der Medienkompetenz und Medienbildung und diskutiert auf Basis des Projekts Eufolio, wie kompetenzorientiertes Lernen mit E-Portfolios einen Beitrag zur Medienbildung leisten kann.

  8. S2k-Leitlinie zum Gebrauch von Präparationen zur lokalen Anwendung auf der Haut (Topika).

    Science.gov (United States)

    Wohlrab, Johannes; Staubach, Petra; Augustin, Matthias; Eisert, Lisa; Hünerbein, Andreas; Nast, Alexander; Reimann, Holger; Strömer, Klaus; Mahler, Vera

    2018-03-01

    Diese Leitlinie richtet sich an Assistenz- und Fachärzte der Dermatologie sowie an Kostenträger und politische Entscheidungsgremien. Die Leitlinie wurde im formellen Konsensusverfahren (S2k) von Dermatologen unter Einbindung von Apothekern erstellt. Die Leitlinie stellt allgemeine Aspekte der Pharmakokinetik sowie der regulatorischen Begrifflichkeiten dar. Es werden Empfehlungen zur Indikation von Magistralrezepturen sowie deren Qualitätssicherung gegeben. Die Bedeutung der galenischen Grundlagen und die Problematik bei einer Substitution gegeneinander verschiedener Grundlagen werden dargestellt. Die Leitlinie umfasst Kriterien zur Auswahl einer adäquaten Grundlage sowie spezifische Aspekte zur Therapieplanung. Die Leitlinie gibt Empfehlungen zum Management bei Unverträglichkeiten gegenüber Bestandteilen der Grundlagen oder Hilfsstoffe. © 2018 The Authors | Journal compilation © Blackwell Verlag GmbH, Berlin.

  9. Renewable energies in Germany. Data on the development in 2016; Erneuerbare Energien in Deutschland. Daten zur Entwicklung im Jahr 2016

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2017-03-15

    The Working Group on Renewable Energy Statistics (AGEE-Stat), which regularly evaluates the use of renewable energies on behalf of the German Federal Ministry of Economics and Energy, has made an initial assessment of the development of renewable energies in Germany on the basis of available, mostly provisional data of 2016. The present background paper describes the previous findings for the areas of electricity, heat and transport, supplemented by figures on economic significance as well as on emission reductions through renewable energies. [German] Die Arbeitsgruppe Erneuerbare Energien-Statistik (AGEE-Stat), die im Auftrag des Bundesministeriums fuer Wirtschaft und Energie regelmaessig die Nutzung der erneuerbaren Energien bilanziert, hat auf der Grundlage verfuegbarer, zumeist vorlaeufiger Daten eine erste Abschaetzung zur Entwicklung der erneuerbaren Energien in Deutschland im Jahr 2016 erstellt. Das vorliegende Hintergrundpapier beschreibt die bisherigen Erkenntnisse fuer die Bereiche Strom, Waerme und Verkehr, ergaenzt um Zahlen zur wirtschaftlichen Bedeutung sowie zur Emissionsvermeidung durch erneuerbare Energien.

  10. The dynamics of slug trains in volcanic conduits: Evidence for expansion driven slug coalescence

    Science.gov (United States)

    Pering, T. D.; McGonigle, A. J. S.; James, M. R.; Capponi, A.; Lane, S. J.; Tamburello, G.; Aiuppa, A.

    2017-12-01

    Strombolian volcanism is a ubiquitous form of activity, driven by the ascent and bursting of bubbles of slug morphology. Whilst considerable attention has been devoted to understanding the behaviour of individual slugs in this regime, relatively little is known about how inter-slug interactions modify flow conditions. Recently, we reported on high temporal frequency strombolian activity on Etna, in which the larger erupted slug masses were followed by longer intervals before the following explosion than the smaller bursts (Pering et al., 2015). We hypothesised that this behaviour arose from the coalescence of ascending slugs causing a prolonged lag before arrival of the next distinct bubble. Here we consider the potential importance of inter-slug interactions for the dynamics of strombolian volcanism, by reporting on the first study into the behaviour of trains of ascending gas slugs, scaled to the expansion rates in volcanic conduits. This laboratory analogue study illustrates that slugs in trains rise faster than individual slugs, and can be associated with aspects of co-current flow. The work also highlights that coalescence and inter-slug interactions play an important role in modulating slug train behaviour. We also report, for the first time, on slug coalescence driven by vertical expansion of the trailing slug, a process which can occur, even where the leading slug base ascent velocity is greater than that of the trailing slug.

  11. Effect of Surface Pore Structure of Nerve Guide Conduit on Peripheral Nerve Regeneration

    Science.gov (United States)

    Oh, Se Heang; Kim, Jin Rae; Kwon, Gu Birm; Namgung, Uk; Song, Kyu Sang

    2013-01-01

    Polycaprolactone (PCL)/Pluronic F127 nerve guide conduits (NGCs) with different surface pore structures (nano-porous inner surface vs. micro-porous inner surface) but similar physical and chemical properties were fabricated by rolling the opposite side of asymmetrically porous PCL/F127 membranes. The effect of the pore structure on peripheral nerve regeneration through the NGCs was investigated using a sciatic nerve defect model of rats. The nerve fibers and tissues were shown to have regenerated along the longitudinal direction through the NGC with a nano-porous inner surface (Nanopore NGC), while they grew toward the porous wall of the NGC with a micro-porous inner surface (Micropore NGC) and, thus, their growth was restricted when compared with the Nanopore NGC, as investigated by immunohistochemical evaluations (by fluorescence microscopy with anti-neurofilament staining and Hoechst staining for growth pattern of nerve fibers), histological evaluations (by light microscopy with Meyer's modified trichrome staining and Toluidine blue staining and transmission electron microscopy for the regeneration of axon and myelin sheath), and FluoroGold retrograde tracing (for reconnection between proximal and distal stumps). The effect of nerve growth factor (NGF) immobilized on the pore surfaces of the NGCs on nerve regeneration was not so significant when compared with NGCs not containing immobilized NGF. The NGC system with different surface pore structures but the same chemical/physical properties seems to be a good tool that is used for elucidating the surface pore effect of NGCs on nerve regeneration. PMID:22871377

  12. Thermo-Hydraulic behaviour of dual-channel superconducting Cable-In-Conduit Conductors for ITER

    International Nuclear Information System (INIS)

    Renard, B.

    2006-09-01

    In an effort to optimise the cryogenics of large superconducting coils for fusion applications (ITER), dual channel Cable-In-Conduit Conductors (CICC) are designed with a central channel spiral to provide low hydraulic resistance and faster helium circulation. The qualitative and economic rationale of the conductor central channel is here justified to limit the superconductor temperature increase, but brings more complexity to the conductor cooling characteristics. The pressure drop of spirals is experimentally evaluated in nitrogen and water and an explicit hydraulic friction model is proposed. Temperatures in the cable must be quantified to guarantee superconductor margin during coil operation under heat disturbance and set adequate inlet temperature. Analytical one-dimensional thermal models, in steady state and in transient, allow to better understand the thermal coupling of CICC central and annular channels. The measurement of a heat transfer characteristic space and time constants provides cross-checking experimental estimations of the internal thermal homogenization. A simple explicit model of global inter-channel heat exchange coefficient is proposed. The risk of thermosyphon between the two channels is considered since vertical portions of fusion coils are subject to gravity. The new hydraulic model, heat exchange model and gravitational risk ratio allow the thermohydraulic improvement of CICC central spirals. (author)

  13. The Medial Temporal Lobe – Conduit of Parallel Connectivity: A model for Attention, Memory, and Perception.

    Directory of Open Access Journals (Sweden)

    Brian B. Mozaffari

    2014-11-01

    Full Text Available Based on the notion that the brain is equipped with a hierarchical organization, which embodies environmental contingencies across many time scales, this paper suggests that the medial temporal lobe (MTL – located deep in the hierarchy – serves as a bridge connecting supra to infra – MTL levels. Bridging the upper and lower regions of the hierarchy provides a parallel architecture that optimizes information flow between upper and lower regions to aid attention, encoding, and processing of quick complex visual phenomenon. Bypassing intermediate hierarchy levels, information conveyed through the MTL ‘bridge’ allows upper levels to make educated predictions about the prevailing context and accordingly select lower representations to increase the efficiency of predictive coding throughout the hierarchy. This selection or activation/deactivation is associated with endogenous attention. In the event that these ‘bridge’ predictions are inaccurate, this architecture enables the rapid encoding of novel contingencies. A review of hierarchical models in relation to memory is provided along with a new theory, Medial-temporal-lobe Conduit for Parallel Connectivity (MCPC. In this scheme, consolidation is considered as a secondary process, occurring after a MTL-bridged connection, which eventually allows upper and lower levels to access each other directly. With repeated reactivations, as contingencies become consolidated, less MTL activity is predicted. Finally, MTL bridging may aid processing transient but structured perceptual events, by allowing communication between upper and lower levels without calling on intermediate levels of representation.

  14. Enhanced peripheral nerve regeneration through asymmetrically porous nerve guide conduit with nerve growth factor gradient.

    Science.gov (United States)

    Oh, Se Heang; Kang, Jun Goo; Kim, Tae Ho; Namgung, Uk; Song, Kyu Sang; Jeon, Byeong Hwa; Lee, Jin Ho

    2018-01-01

    In this study, we fabricated a nerve guide conduit (NGC) with nerve growth factor (NGF) gradient along the longitudinal direction by rolling a porous polycaprolactone membrane with NGF concentration gradient. The NGF immobilized on the membrane was continuously released for up to 35 days, and the released amount of the NGF from the membrane gradually increased from the proximal to distal NGF ends, which may allow a neurotrophic factor gradient in the tubular NGC for a sufficient period. From the in vitro cell culture experiment, it was observed that the PC12 cells sense the NGF concentration gradient on the membrane for the cell proliferation and differentiation. From the in vivo animal experiment using a long gap (20 mm) sciatic nerve defect model of rats, the NGC with NGF concentration gradient allowed more rapid nerve regeneration through the NGC than the NGC itself and NGC immobilized with uniformly distributed NGF. The NGC with NGF concentration gradient seems to be a promising strategy for the peripheral nerve regeneration. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 52-64, 2018. © 2017 Wiley Periodicals, Inc.

  15. A new cable-in-conduit conductor magnet with insulated strands

    International Nuclear Information System (INIS)

    Yamaguchi, Satarou; Yamamoto, Junya; Motojima, Osamu.

    1995-09-01

    Many studies have used cable-in-conduit conductor (CICC) coils in trying to develop an AC superconducting magnet because of its enormous potential if AC losses were low and insulation voltage was high. The strands in the most recent CICC magnets are coated with chromium or another metal with high electrical resistance to order to induce current re-distribution among the strands and to avoid a quench caused by a current imbalance. Current re-distribution is highly complex and very difficult to analyze because the conditions of the strand surfaces and the contact areas vary greatly with the operation of the conductor. If, however, the cable currents were well-balanced, insulating the strands would be the best way to reduce AC losses. We propose a new CICC magnet structure featuring a current lead that balances the strand currents via its resistance. Having calculated current balances, we find that strand currents are well within the present parameters for nuclear fusion experiments and superconducting magnet energy storages. (author)

  16. A Decaheme Cytochrome as a Molecular Electron Conduit in Dye-Sensitized Photoanodes

    Science.gov (United States)

    Hwang, Ee Taek; Sheikh, Khizar; Orchard, Katherine L; Hojo, Daisuke; Radu, Valentin; Lee, Chong-Yong; Ainsworth, Emma; Lockwood, Colin; Gross, Manuela A; Adschiri, Tadafumi; Reisner, Erwin; Butt, Julea N; Jeuken, Lars J C

    2015-01-01

    In nature, charge recombination in light-harvesting reaction centers is minimized by efficient charge separation. Here, it is aimed to mimic this by coupling dye-sensitized TiO2 nanocrystals to a decaheme protein, MtrC from Shewanella oneidensis MR-1, where the 10 hemes of MtrC form a ≈7-nm-long molecular wire between the TiO2 and the underlying electrode. The system is assembled by forming a densely packed MtrC film on an ultra-flat gold electrode, followed by the adsorption of approximately 7 nm TiO2 nanocrystals that are modified with a phosphonated bipyridine Ru(II) dye (RuP). The step-by-step construction of the MtrC/TiO2 system is monitored with (photo)electrochemistry, quartz-crystal microbalance with dissipation (QCM-D), and atomic force microscopy (AFM). Photocurrents are dependent on the redox state of the MtrC, confirming that electrons are transferred from the TiO2 nanocrystals to the surface via the MtrC conduit. In other words, in these TiO2/MtrC hybrid photodiodes, MtrC traps the conduction-band electrons from TiO2 before transferring them to the electrode, creating a photobioelectrochemical system in which a redox protein is used to mimic the efficient charge separation found in biological photosystems. PMID:26180522

  17. Reverse saphenous conduit flap in small animals: Clinical applications and outcomes

    Directory of Open Access Journals (Sweden)

    Ross C. Elliott

    2014-08-01

    Full Text Available Due to the lack of skin elasticity defects of the distal hind limb can be a challenge to close. This article assesses a well-described, but completely under-used technique for closure of wounds on the distal tarsus. The technique was used with good success in six cases presenting to the Bryanston Veterinary Hospital with a wide range of underlying pathology ranging from trauma to neoplastic disease of the tarsus. All six cases were treated with a reverse saphenous conduit flap and two of them underwent radiation therapy with no adverse side effects. All cases showed excellent results with a very low degree of flap necrosis that never exceeded 15% of the total flap area. This skin flap provides an excellent treatment method that is reliable in closure of defects of the distal tarsus with few adverse effects. To the author’s knowledge there has been only one previously published report on the clinical use of this type of skin flap,even though the flap is well described in most texts.

  18. Normal zone propagation and Thermal Hydraulic Quenchback in a cable-in-conduit superconductor

    International Nuclear Information System (INIS)

    Lue, J.W.; Dresner, L.

    1993-01-01

    When a local normal zone appears in a cable-in-conduit superconductor, a slug of hot helium is produced. The pressure rises and the hot helium expands. Thus the normal zone propagation in such a conductor can be governed by the hot helium expansion, rather than the heat conduction along the conductor. The expansion of the hot helium compresses the cold helium outside of the normal zone. This raises th at sign temperature of the cold helium. When the temperature rise reaches the current sharing limit, the superconductor in contact goes normal. Thus a rapid increase in normal zone propagation occur. This phenomenon is termed Thermal Hydraulic Quenchback (THQ). An experiment was performed to investigate this process. The existence of THQ was verified. Thresholds of THQ were also observed by varying the conductor current, the magnetic field, the temperature, and the initial normal zone length. When THQ occurred, normal zone propagation approaching the velocity of sound was observed. A better picture of THQ is obtained by a careful comparison of the data with analytical studies

  19. Solid-cryogen-stabilized, cable-in-conduit (CIC) superconducting cables

    Science.gov (United States)

    Voccio, J. P.; Michael, P. C.; Bromberg, L.; Hahn, S.

    2015-12-01

    This paper considers the use of a solid cryogen as a means to stabilize, both mechanically and thermally, magnesium diboride (MgB2) superconducting strands within a dual-channel cable-in-conduit (CIC) cable for use in AC applications, such as a generator stator winding. The cable consists of two separate channels; the outer channel contains the superconducting strands and is filled with a fluid (liquid or gas) that becomes solid at the device operating temperature. Several options for fluid will be presented, such as liquid nitrogen, hydrocarbons and other chlorofluorocarbons (CFCs) that have a range of melting temperatures and volumetric expansions (from solid at operating temperature to fixed volume at room temperature). Implications for quench protection and conductor stability, enhanced through direct contact with the solid cryogen, which has high heat capacity and thermal conductivity (compared with helium gas), will be presented. Depending on the cryogen, the conductor will be filled initially either with liquid at atmospheric conditions or a gas at high pressure (∼100 atm). After cooldown, the cryogen in the stranded-channel will be solid, essentially locking the strands in place, preventing strand motion and degradation due to mechanical deformation while providing enhanced thermal capacity for stability and protection. The effect of cryogen porosity is also considered. The relatively high heat capacity of solid cryogens at these lower temperatures (compared to gaseous helium) enhances the thermal stability of the winding. During operation, coolant flow through the open inner channel will minimize pressure drop.

  20. Literature Review: Double-Barrelled Wet Colostomy (One Stoma) versus Ileal Conduit with Colostomy (Two Stomas).

    Science.gov (United States)

    Gan, Jason; Hamid, Rizwan

    2017-01-01

    The aim of this literature review was to analyse the advantages and disadvantages of a traditional ileal conduit (IC) with separate colostomy technique compared to the outcomes of a double-barrelled wet colostomy (DBWC) technique. The former technique results in the formation of two stomas, and the latter results in the formation of one stoma. PubMed was searched electronically for articles on DBWC. Fifteen articles were retrieved and of them 13 were included in the literature review (350 patients). Of the articles, 3 directly compared DBWC to IC with colostomy. Review of 13 DBWC articles demonstrated perioperative mortality ranging between 0 and 11.1% and postoperative complications ranging from 0 to 100%. Three of the studies directly compared DBWC to IC with colostomy; median operating times and length of stay were shorter in DBWC patients (p colostomy technique, as it requires only one stoma. This literature review supports the use of the technically less challenging DBWC technique as a viable alternative to the traditional IC with colostomy technique. © 2016 S. Karger AG, Basel.

  1. The effects of fenoldopam on coronary conduit blood flow after coronary artery bypass graft surgery.

    LENUS (Irish Health Repository)

    Halpenny, M

    2012-02-03

    OBJECTIVE: To quantify the effects of fenoldopam, 0.1 microg\\/kg\\/min, on left internal mammary artery (LIMA) and saphenous vein blood flow after coronary anastomosis. DESIGN: Prospective, randomized, double-blind, placebo-controlled trial. SETTING: University teaching hospital, single institution. PARTICIPANTS: Thirty-one American Society of Anesthesiologists III patients undergoing elective coronary revascularization. INTERVENTIONS: A perivascular ultrasonic flow probe (Linton Instrumentation, Norfolk, UK) was placed around the LIMA and saphenous vein graft after coronary anastomosis. MEASUREMENTS AND MAIN RESULTS: Immediately before and at 5-minute intervals for 15 minutes after starting the infusion, blood flow was measured in the LIMA and one saphenous vein graft using a transit time ultrasonic flow probe. Heart rate, blood pressure, and central venous pressure were documented at these time points. Administration of fenoldopam, 0.1 microg\\/kg\\/min, did not alter heart rate or blood pressure. A small, nonsignificant increase in LIMA blood flow occurred during the 15-minute study period (30 +\\/- 12 to 35 +\\/- 10 mL\\/min) in patients who received fenoldopam. No significant changes occurred in the placebo group. CONCLUSIONS: The findings indicate that fenoldopam, 0.1 microg\\/kg\\/min, did not influence coronary conduit blood flow to a clinically significant extent. The small increase in LIMA blood flow may be of greater importance in high-risk patients or in the prevention of coronary arterial spasm.

  2. Exploring the role of lipids in intercellular conduits: breakthroughs in the pipeline

    Directory of Open Access Journals (Sweden)

    Elise eDelage

    2013-12-01

    Full Text Available It has been known for more than a century that most of the plant cells are connected to their neighbors through membranous pores perforating the cell wall, namely plasmodesmata (PDs. The recent discovery of tunneling nanotubes (TNTs, thin membrane bridges established between distant mammalian cells, suggests that intercellular communication mediated through cytoplasmic continuity could be a conserved feature of eukaryotic organisms. Although TNTs differ from PDs in their formation and architecture, both are characterized by a continuity of the plasma membrane between two cells, delimiting a nanotubular channel supported by actin-based cytoskeleton. Due to this unusual membrane organization, lipids are likely to play critical roles in the formation and stability of intercellular conduits like TNTs and PDs, but also in regulating the transfer through these structures. While it is crucial for a better understanding of those fascinating communication highways, the study of TNT lipid composition and dynamics turned out to be extremely challenging. The present review aims to give an overview of the recent findings in this context. We will also discuss some of the promising imaging approaches, which might be the key for future breakthroughs in the field and could also benefit the research on PDs.

  3. Contention between supply of hydrothermal fluid and conduit obstruction: inferences from numerical simulations

    Science.gov (United States)

    Tanaka, Ryo; Hashimoto, Takeshi; Matsushima, Nobuo; Ishido, Tsuneo

    2018-05-01

    We investigate a volcanic hydrothermal system using numerical simulations, focusing on change in crater temperature. Both increases and decreases in crater temperature have been observed before phreatic eruptions. We follow the system's response for up to a decade after hydrothermal fluid flux from the deep part of the system is increased and permeability is reduced at a certain depth in a conduit. Our numerical simulations demonstrate that: (1) changes in crater temperature are controlled by the magnitude of the increase in hydrothermal fluid flux and the degree of permeability reduction; (2) significant increases in hydrothermal flux with decreases in permeability induce substantial pressure changes in shallow depths in the edifice and decreases in crater temperature; (3) the location of maximum pressure change differs between the mechanisms. The results of this study imply that it is difficult to predict eruptions by crater temperature change alone. One should be as wary of large eruptions when crater temperature decreases as when crater temperature increases. It is possible to clarify the implications of changes in crater temperature with simultaneous observation of ground deformation.

  4. Glacier surge mechanism based on linked cavity configuration of the basal water conduit system

    Science.gov (United States)

    Kamb, Barclay

    1987-08-01

    Based on observations of the 1982-1983 surge of Variegated Glacier, Alaska, a model of the surge mechanism is developed in terms of a transition from the normal tunnel configuration of the basal water conduit system to a linked cavity configuration that tends to restrict the flow of water, resulting in increased basal water pressures that cause rapid basal sliding. The linked cavity system consists of basal cavities formed by ice-bedrock separation (cavitation), ˜1 m high and ˜10 m in horizontal dimensions, widely scattered over the glacier bed, and hydraulically linked by narrow connections where separation is minimal (separation gap ≲ 0.1 m). The narrow connections, called orifices, control the water flow through the conduit system; by throttling the flow through the large cavities, the orifices keep the water flux transmitted by the basal water system at normal levels even though the total cavity cross-sectional area (˜200 m2) is much larger than that of a tunnel system (˜10 m2). A physical model of the linked cavity system is formulated in terms of the dimensions of the "typical" cavity and orifice and the numbers of these across the glacier width. The model concentrates on the detailed configuration of the typical orifice and its response to basal water pressure and basal sliding, which determines the water flux carried by the system under given conditions. Configurations are worked out for two idealized orifice types, step orifices that form in the lee of downglacier-facing bedrock steps, and wave orifices that form on the lee slopes of quasisinusoidal bedrock waves and are similar to transverse "N channels." The orifice configurations are obtained from the results of solutions of the basal-sliding-with-separation problem for an ice mass constituting of linear half-space of linear rheology, with nonlinearity introduced by making the viscosity stress-dependent on an intuitive basis. Modification of the orifice shapes by melting of the ice roof due to

  5. The side-to-side fashion for individual distal coronary anastomosis using venous conduit.

    Science.gov (United States)

    Kato, Takayoshi; Tsunekawa, Tomohiro; Motoji, Yusuke; Hirakawa, Akihiro; Okawa, Yasuhide; Tomita, Shinji

    2017-04-01

    Regarding to coronary artery bypass grafting (CABG), the end-to-side anastomosis (ESA) has been performed as a gold standard. Recently, the effectiveness of the distal side-to-side anastomosis (SSA) in CABG using internal mammary artery has been reported. The benefit of SSA comparing to ESA also has been disclosed by computing simulation. However, use of SSA by venous conduit for individual CABG has not been reported. In this study, we investigated feasibility of SSA. From January 2013 to October 2014, we conducted 114 CABGs. There were 92 venous distal anastomoses without sequential anastomotic site (61 SSA and 31 ESA). The anastomosis was evaluated before discharge and at 1 year after the procedure by angiography or multi-detector row computed tomographic coronary angiography. The median values for time to anastomosis were 13 min in the two group (p = 0.89). There was no revision of anastomosis in both groups. Additional stitches for hemostasis were required significantly less in SSA than ESA (18.0 vs 45.2 %, respectively, p fashion is easy to perform and maybe beneficial in blood flow pattern.

  6. Klinische Studie zur Messung der Dimensionsstabilität von digitalen Ganzkieferabformungen und die Entwicklung einer neuen Messmethode

    OpenAIRE

    Kuhr, Fabian

    2016-01-01

    Digitale Abformungen mit intraoralen Scannern haben klinisch bereits bewiesen, dass sie einzelne Zähne detail- und dimensionsgenau aufnehmen und in dieser Hinsicht eine Alternative zur konventionellen zahnärztlichen Abformung bieten können. Ob dies klinisch auch mit dem Scannen gesamter Zahnreihen möglich ist, wurde bislang nicht untersucht. Sowohl für konventionelle wie auch für digitale Abformungen gibt es keine In-vivo-Studie, die eine Methode zur Überprüfung der dimensionsgetreuen Übertra...

  7. Neural network based inspection of voids and karst conduits in hydro-electric power station tunnels using GPR

    Science.gov (United States)

    Kilic, Gokhan; Eren, Levent

    2018-04-01

    This paper reports on the fundamental role played by Ground Penetrating Radar (GPR), alongside advanced processing and presentation methods, during the tunnel boring project at a Dam and Hydro-Electric Power Station. It identifies from collected GPR data such issues as incomplete grouting and the presence of karst conduits and voids and provides full details of the procedures adopted. In particular, the application of collected GPR data to the Neural Network (NN) method is discussed.

  8. Brachial artery repair using the basilic vein as a reliable conduit in a 3-year-old child

    Directory of Open Access Journals (Sweden)

    Hyunyoung G. Kim

    2017-04-01

    Full Text Available A supracondylar fracture of the humerus is the most common upper extremity fracture in children with concurrent neurovascular complications. However, bypass grafting in the management of a pediatric open elbow dislocation with an arterial injury has rarely been reported in the literature. Hence, an adequate conduit for a vessel graft interposition remains questionable when a primary anastomosis is limited in an arterial reconstruction. The purpose of this study is to present a brachial artery reconstruction in a 3-year-old patient with an open supracondylar fracture of the humerus. In the clinical and surgical examination of the patient, an open wound in the left antecubital fossa presented with accompanying brachial artery injury. To repair the artery, a reverse end-to-end anastomosis was conducted using basilic vein graft from the ipsilateral arm under general anesthesia. The patient had palpable radial pulses in the postoperative clinical examination and was discharged without complications. The great saphenous vein (GSV has proven to be the most common and the best conduit for arterial reconstruction of the upper extremity in the adult patients. However, the GSV graft is known to have the propensity for becoming aneurysmal in pediatric patients. Some studies have demonstrated the basilic vein as a suitable conduit in pediatric patients, in that it has durable patency, fewer branches, size compatibility for anastomosis, and proximity to the brachial artery. Our case confirms the safety of using this autogenous vein from within the zone of injury for arterial reconstruction, after a supracondylar humeral fracture. The management of pediatric elbow fractures accompanying vascular injuries can be technically demanding due to relatively small, delicate structures and concurrent neurovascular network. Nonetheless, a vascular injury should be treated with high level of suspicion and immediate intervention to avoid any limb ischemia or loss. In

  9. Field observations of extended seawater intrusion through subsurface karst conduit networks at Wakulla Spring in the Woodville Karst Plain, Florida

    Science.gov (United States)

    Xu, Z.; Bassett, S.; Hu, B. X.; Dyer, S.

    2016-12-01

    Five periods of increased electrical conductivity have been found in the karst conduits supplying one of the largest first magnitude springs in Florida with water. Numerous well-developed conduit networks are distributed in the Woodville Karst Plain (WKP), Florida and connected to the Gulf of Mexico. A composite analysis of precipitation and electric conductivity data provides strong evidence that the increases in conductivity are directly tied to seawater intrusion moving inland and traveling 14 miles against the prevailing regional hydraulic gradient from from Spring Creek Spring Complex (SCSC), a group of submarine springs at the Gulf Coast. A geochemical analysis of samples from the spring vent rules out anthropogenic contamination and upwelling regional recharge from the deep aquifer as sources of the rising conductivity. The interpretation is supported by the conceptual model established by prior researchers working to characterize the study area. This abstract documented the first and longest case of seawater intrusion in the WKP, and also indicates significant possibility of seawater contamination through subsurface conduit networks in a coastal karst aquifer.

  10. Towards a Tissue-Engineered Contractile Fontan-Conduit: The Fate of Cardiac Myocytes in the Subpulmonary Circulation.

    Directory of Open Access Journals (Sweden)

    Daniel Biermann

    Full Text Available The long-term outcome of patients with single ventricles improved over time, but remains poor compared to other congenital heart lesions with biventricular circulation. Main cause for this unfavourable outcome is the unphysiological hemodynamic of the Fontan circulation, such as subnormal systemic cardiac output and increased systemic-venous pressure. To overcome this limitation, we are developing the concept of a contractile extracardiac Fontan-tunnel. In this study, we evaluated the survival and structural development of a tissue-engineered conduit under in vivo conditions. Engineered heart tissue was generated from ventricular heart cells of neonatal Wistar rats, fibrinogen and thrombin. Engineered heart tissues started beating around day 8 in vitro and remained contractile in vivo throughout the experiment. After culture for 14 days constructs were implanted around the right superior vena cava of Wistar rats (n = 12. Animals were euthanized after 7, 14, 28 and 56 days postoperatively. Hematoxylin and eosin staining showed cardiomyocytes arranged in thick bundles within the engineered heart tissue-conduit. Immunostaining of sarcomeric actin, alpha-actin and connexin 43 revealed a well -developed cardiac myocyte structure. Magnetic resonance imaging (d14, n = 3 revealed no constriction or stenosis of the superior vena cava by the constructs. Engineered heart tissues survive and contract for extended periods after implantation around the superior vena cava of rats. Generation of larger constructs is warranted to evaluate functional benefits of a contractile Fontan-conduit.

  11. Hydraulic analysis of harmonic pumping tests in frequency and time domains for identifying the conduits networks in a karstic aquifer

    Science.gov (United States)

    Fischer, P.; Jardani, A.; Cardiff, M.; Lecoq, N.; Jourde, H.

    2018-04-01

    In a karstic field, the flow paths are very complex as they globally follow the conduit network. The responses generated from an investigation in this type of aquifer can be spatially highly variable. Therefore, the aim of the investigation in this case is to define a degree of connectivity between points of the field, in order to understand these flow paths. Harmonic pumping tests represent a possible investigation method for characterizing the subsurface flow of groundwater. They have several advantages compared to a constant-rate pumping (more signal possibilities, ease of extracting the signal in the responses and possibility of closed loop investigation). We show in this work that interpreting the responses from a harmonic pumping test is very useful for delineating a degree of connectivity between measurement points. We have firstly studied the amplitude and phase offset of responses from a harmonic pumping test in a theoretical synthetic modeling case in order to define a qualitative interpretation method in the time and frequency domains. Three different type of responses have been separated: a conduit connectivity response, a matrix connectivity, and a dual connectivity (response of a point in the matrix, but close to a conduit). We have then applied this method to measured responses at a field research site. Our interpretation method permits a quick and easy reconstruction of the main flow paths, and the whole set of field responses appear to give a similar range of responses to those seen in the theoretical synthetic case.

  12. Indications for surgical resection of benign pancreatic tumors; Indikationen zur chirurgischen Therapie benigner Pankreastumoren

    Energy Technology Data Exchange (ETDEWEB)

    Isenmann, R.; Henne-Bruns, D. [Chirurgische Universitaetsklinik, Klinik fuer Allgemein-, Viszeral- und Transplantationschirurgie, Ulm (Germany)

    2008-08-15

    Benign pancreatic tumors should undergo surgical resection when they are symptomatic or - in the case of incidental discovery - bear malignant potential. This is the case for the majority of benign pancreatic tumors, especially for intraductal papillary mucinous neoplasms or mucinous cystic adenomas. In addition, resection is indicated for all tumors where preoperative diagnostic fails to provide an exact classification. Several different operative techniques are available. The treatment of choice depends on the localization of the tumor, its size and on whether there is evidence of malignant transformation. Partial duodenopancreatectomy is the oncological treatment of choice for tumors of the pancreatic head whereas for tumors of the pancreatic tail a left-sided pancreatectomy is appropriate. Middle pancreatectomy or duodenum-preserving resection of the pancreatic head is not a radical oncologic procedure. They should only be performed in cases of tumors without malignant potential. (orig.) [German] Die Indikationsstellung zur Resektion benigner Pankreastumoren ist gegeben, wenn es sich um einen symptomatischen Tumor handelt oder - bei einem Zufallsbefund - um einen Tumor mit Potenzial zur malignen Entartung. Dies besteht bei der Mehrzahl der benignen Pankreastumoren, insbesondere bei der intraduktalen papillaeren muzinoesen Neoplasie (IPMN) oder muzinoesen Zystadenomen. Operativer Abklaerung beduerfen auch Tumoren, die unter Ausschoepfung aller diagnostischer Moeglichkeiten nicht eindeutig klassifizierbar sind. An chirurgischen Therapieverfahren stehen verschiedene Techniken zur Verfuegung. Die Wahl des Verfahren haengt von der Groesse und Lokalisation des Tumors ab und von der Frage, ob eine maligne Entartung bereits stattgefunden hat. Das onkologisch korrekte Standardresektionsverfahren bei Tumoren des Pankreaskopfes ist die partielle Duodenopankreatektomie, bei Tumoren des Pankreasschwanzes die Pankreaslinksresektion. Eine segmentale Resektion des

  13. Prüfungen zur Beurteilung der Brandgefahr; Anleitung für die Aufstellung von Anforderungen und Prüfbestimmungen zur Beurteilung der Brandgefahr von elektrotechnischen Erzeugnissen; 1-2: Anleitung für Bauelemente der Elektronik; Identisch mit IEC 60695-1-2, Ausgabe 1982

    CERN Document Server

    Deutsches Institut für Normung. Berlin

    1986-01-01

    Prüfungen zur Beurteilung der Brandgefahr; Anleitung für die Aufstellung von Anforderungen und Prüfbestimmungen zur Beurteilung der Brandgefahr von elektrotechnischen Erzeugnissen; 1-2: Anleitung für Bauelemente der Elektronik; Identisch mit IEC 60695-1-2, Ausgabe 1982

  14. Prüfungen zur Beurteilung der Brandgefahr; Beispiele für Verfahren zur Beurteilung einer Brandgefahr und für die Auslegung von Ergebnissen; 3.1: Kennwerte der Verbrennung und Übersicht über Prüfverfahren zu ihrer Ermittlung; Identisch mit IEC 60695-3-1, Ausgabe 1982

    CERN Document Server

    Deutsches Institut für Normung. Berlin

    1986-01-01

    Prüfungen zur Beurteilung der Brandgefahr; Beispiele für Verfahren zur Beurteilung einer Brandgefahr und für die Auslegung von Ergebnissen; 3.1: Kennwerte der Verbrennung und Übersicht über Prüfverfahren zu ihrer Ermittlung; Identisch mit IEC 60695-3-1, Ausgabe 1982

  15. Egypt`s potential for geothermal energy use and underground storage of thermal energy; Moeglichkeiten zur Nutzung geothermischer Energie und zur unterirdischen thermischen Energiespeicherung in Aegypten

    Energy Technology Data Exchange (ETDEWEB)

    Abbas, A M; Sanner, B; Knoblich, K [Giessen Univ. (Germany). Inst. fuer Angewandte Geowissenschaften

    1997-12-01

    Egypt belongs to the arid to extremely arid zone. Hot springs or wells are chiefly distributed over the areas of the Golf of Suez shoreline, along the Red Sea coast and in the Bahariya, Dakhla and Kharga oasis in the Western Desert. The Red Sea with it`s branches into the Gulf of Suez and the Gulf of Aqaba/Jordan valley is the northern end of the East African Rift, which is tectonically active and yields further south known geothermal resources (e.g. in Kenya). Thus, a relatively high het flow zone exists on the eastern border of the Gulf of Suez, on Sinai peninsula. The hot springs of Ayun Musa, Hammam Faraon and El Sokhna are located there. Hammam Faroun is the hottest spring in Egypt with water temperature of approx. 70 C. This paper compiles previous studies from Egypt to elucidate the geothermal potential of Egypt and opportunities to make use of it. (orig.) [Deutsch] Aegypten gehoert zur ariden bis extrem ariden Zone. Heisse Quellen oder erbohrte heisse Waesser finden sich hauptsaechlich entlang der Kueste des Golfs von Suez und des Roten Meeres, sowie in den Oasen Bahariya, Dakhla und Kharga in der westlichen Wueste. Das Rote Meer mit seinen Verzweigungen in den Golf von Suez und in den Golf von Akaba/Jordangraben bildet den noerdlichen Abschluss des Ostafrikanischen Grabensystems, das tektonisch sehr aktiv ist und weiter suedlich (z.B. in Kenia) bekannte geothermische Ressourcen bietet. Eine Zone mit hohem geothermischen Waermefluss befindet sich dementsprechend auch am oestlichen Rand des Golfs von Suez, der zur Halbinsel Sinai gehoehrt. Hier werden die heissen Quellen von Ayun Musa, Hammam Faraon und El Sokhna angetroffen. Hammam Faraon ist die heisseste Quelle Aegyptens mit Wassertemperaturen von etwa 70 C. Die vorliegende Arbeit versucht, einige fruehere Studien aus Aegypten zusammenzufassen und das geothermische Potential Aegyptens mit den Moeglichkeiten seiner Nutzung aufzuzeigen. (orig.)

  16. Testgütekriterien des Fragebogens AnMS-Sport zur Erfassung des Anschlussmotivs im Sportkontext

    DEFF Research Database (Denmark)

    Elbe, Anne-Marie; Krippl, Martin; Melzer, Marcus

    2013-01-01

    , the questionnaire shows satisfactory Cronbach’s alpha. Construct validity is shown through correlations with two general questionnaires to measure the affiliation motive (Krippl, Itemanalytische Untersuchungen zur Selbstbeschreibung von Emotion und Motivation, 1999; Teubel, Eine deutsche Übersetzung der Mehrabian......In this paper the test control criteria of the sport-specific Affiliation Motives Scale-Sport are reported. Theoretical background for the development of the scale is the affiliation motive, which is composed of the two factors “hope for affiliation”and “fear of rejection” (Mehrabian and Ksionzkys...

  17. Heat recovery in sewage sludge gasification systems; Waermerueckgewinnung bei Anlagen zur Klaerschlammvergasung

    Energy Technology Data Exchange (ETDEWEB)

    Lamp, P.; Reichel, A.; Ziegler, F. [Bayerisches Zentrum fuer Angewandte Energieforschung e.V. (ZAE Bayern), Abt. Energieumwandlung und -speicherung, Garching (Germany)

    1996-12-31

    Using the example of a pilot plant for sewage sludge gasification by the Noell conversion process, the potential for energy optimisation is described. The goals of development are twofold: First, the process stages must be optimized so as to minimize energy consumption and secondly, all options for energy use and energy must be utilized. (orig) [Deutsch] Anhand einer Pilotanlage zur Klaerschlammvergasung nach dem NOELL-Konversionsverfahren sollen Moeglichkeiten der energetischen Optimierung beispielhaft aufgezeigt werden. Ziel muss es sein, zum einen die Verfahrensschritte auf einen moeglichst geringen Energiebedarf hin zu optimieren und zum anderen Moeglichkeiten der Waermeverschiebung und -rueckgewinnung soweit wie moeglich auszunutzen. (orig)

  18. Heat recovery in sewage sludge gasification systems; Waermerueckgewinnung bei Anlagen zur Klaerschlammvergasung

    Energy Technology Data Exchange (ETDEWEB)

    Lamp, P; Reichel, A; Ziegler, F [Bayerisches Zentrum fuer Angewandte Energieforschung e.V. (ZAE Bayern), Abt. Energieumwandlung und -speicherung, Garching (Germany)

    1997-12-31

    Using the example of a pilot plant for sewage sludge gasification by the Noell conversion process, the potential for energy optimisation is described. The goals of development are twofold: First, the process stages must be optimized so as to minimize energy consumption and secondly, all options for energy use and energy must be utilized. (orig) [Deutsch] Anhand einer Pilotanlage zur Klaerschlammvergasung nach dem NOELL-Konversionsverfahren sollen Moeglichkeiten der energetischen Optimierung beispielhaft aufgezeigt werden. Ziel muss es sein, zum einen die Verfahrensschritte auf einen moeglichst geringen Energiebedarf hin zu optimieren und zum anderen Moeglichkeiten der Waermeverschiebung und -rueckgewinnung soweit wie moeglich auszunutzen. (orig)

  19. Zur Interaktion von Genotyp und Ernährung bei Darmkrebs

    OpenAIRE

    Behrends, Thomas

    2013-01-01

    Ziel dieser Arbeit war es, sowohl die Auswirkungen einer veränderten Selenversorgung über die Nahrung als auch die Rolle des zentralen Transport- und Speicherproteins für Selen (Selenoprotein P, SepP) auf die intestinale Tumorigenese tierexperimentell zu untersuchen. Eine gestörte SepP-Expression, führte zur Ausbildung größerer Tumore. Durch eine Steigerung der Selenversorgung über die Nahrung eine signifikante Reduktion von Tumoranzahl und Gesamttumorfläche erzielt werden. Hierzu wurde den ...

  20. Anwendung stabiler Isotope zur Beschreibung des mikrobiellen Abbaus organischer Schadstoffe in kontaminierten Aquiferen

    OpenAIRE

    Vieth, Andrea

    2003-01-01

    Der mikrobielle in-situ Abbau organischer Schadstoffe ist mit einer Änderung der Isotopenverhältnisse (12C/13C; H/D) verbunden. Das Ausmaß der Isotopenfraktionierung ist abhängig von der initialen biochemischen Reaktion und variiert mit der Größe des Substratmoleküls bzw. der Anzahl der Kohlenstoff- bzw. Wasserstoffatome. Für die Anwendung dieses Isotopenkonzepts zur Beschreibung des mikrobiellen Abbaus von Schadstoffen im Grundwasser muss ausgeschlossen werden können, dass andere Prozesse ei...

  1. Digital announcements from data carrier exchange to telecommunication; Digitale Ausschreibungen; vom Datentraegeraustausch zur Telekommunikation

    Energy Technology Data Exchange (ETDEWEB)

    Markert, H. [MW Software GmbH, Koeln (Germany)

    1995-12-31

    In chapter 7 of the anthology about building control digital announcements are described ranging from data carrier exchange to telecommunication. The following aspects are discussed: Exchange of texts and prices as well of service lists and offers, telecommunication software, costs of communication, comparison of paper, disk and telecommunication. (BWI) [Deutsch] Kapitel 7 des Sammelbandes ueber Building Control ist dem Thema der digitalen Ausschreibung gewidmet, reichend vom Datentraegeraustausch zur Telekommunikation. In diesem Zusammenhang wird auf folgende Themen eingegangen: Austausch von Texten und Preisen sowie von Leistungsverzeichnissen und Angeboten; Telekommunikations-Software; Kosten der Kommunikation sowie Vergleich Papier - Diskette - Telekommunikation. (BWI)

  2. The step from the project control to long-distance control; Von der Projekt- zur Fernkontrolle

    Energy Technology Data Exchange (ETDEWEB)

    Kaelin, W. [Ingenieurbuero Werner Kaelin, Schwyz (Switzerland)

    1995-12-31

    In chapter 8 of the anthology about building control the extension from project control to long-distance control is described. The following aspects are discussed: guidelines (operating concept, task anthology), project (implementation, control, documentation), realisation (initiation, example), operation (regional co-operation, characteristic numbers). (BWI) [Deutsch] Kapitel 8 des Sammelbandes ueber Building Control ist dem Ausbau von der Projekt- zur Fernkontrolle gewidmet. In diesem Zusammenhang werden folgende Themen angesprochen: Vorgaben (Betriebskonzept, Pflichtenheft), Projekt (Umsetzung, Kontrolle, Dokumentation), Ausfuehrung (Inbetriebsetzung, Beispiel); Betrieb (regionaler Zusammenschluss, Kennzahlen). (BWI)

  3. Zusammenarbeit, Sichtbarkeit, Einbindung und Effizienz : Fallstudie zur Verwendung interaktiver Whiteboards an einem Gymnasium in Deutschland

    OpenAIRE

    Passey, Donald

    2017-01-01

    Dieser Bericht bietet einen Überblick über die Ergebnisse einer einjährigen Studie, die an einer deutschen Schule (Gymnasium) in einer Stadt in Nordrhein-Westfalen (NRW) durchgeführt wurde. Während ein Forschungsschwerpunkt auf dem Thema „Zusammenarbeit“ lag, erforderte auch die Planung und Durchführung der Studie gemeinsame Anstrengungen: Die Schule hatte ihren Anteil an der Implementation interaktiver Whiteboards; SMART Technologies stellte Ausrüstung und technische Unterstützung zur Verfüg...

  4. Die muslimische Gemeinschaft Rumäniens: der Weg einer Elite zur marginalisierten Minderheit

    OpenAIRE

    Kahl, Thede

    2005-01-01

    Die Siedlungsgeschichte der Muslime auf dem Territorium des heutigen Rumäniens geht in das 13. Jahrhundert zurück. Durch verstärkte Einwanderung von Turkmenen und Tataren konnten sich im Laufe der folgenden Jahrhunderte Regionen mit muslimischer kultureller Dominanz ausbilden. Aufgrund der Kolonisierungspolitik der osmanischen Sultane im Laufe des 14.-16. Jahrhunderts erhöhte sich Zahl der Muslime ständig, da sie sowohl aus dem Norden des Schwarzen Meeres als auch aus dem Süden (Kleinasien) Z...

  5. Sprechkompetenz im DaF-Unterricht an Slowenischen Gymnasien: von der Theorie zur Praxis

    Directory of Open Access Journals (Sweden)

    Andreja Retelj

    2016-12-01

    Full Text Available Es liegt auf der Hand, dass Fremdsprachenkenntnisse aufgrund der wachsenden Globalisierung stets an Bedeutung gewinnen. Über eine hochentwickelte Fremdsprachenkompetenz zu verfügen, ist in der heutigen Gesellschaft fast zur Selbstverständlichkeit geworden. Durch die wachsenden wirtschaftlichen Kontakte gewinnt vor allem die mündliche Kommunikation immer mehr an Bedeutung und die Erwartungen an Fremdsprachenlernende, in verschiedenen Sprachsituationen mündlich schnell und angemessen kommunizieren zu können, nehmen aus diesem Grund ständig zu.

  6. Water exchange and pressure transfer between conduits and matrix and their influence on hydrodynamics of two karst aquifers with sinking streams

    Science.gov (United States)

    Bailly-Comte, Vincent; Martin, Jonathan B.; Jourde, Hervé; Screaton, Elizabeth J.; Pistre, Séverin; Langston, Abigail

    2010-05-01

    SummaryKarst aquifers are heterogeneous media where conduits usually drain water from lower permeability volumes (matrix and fractures). For more than a century, various approaches have used flood recession curves, which integrate all hydrodynamic processes in a karst aquifer, to infer physical properties of the movement and storage of groundwater. These investigations typically only consider flow to the conduits and thus have lacked quantitative observations of how pressure transfer and water exchange between matrix and conduit during flooding could influence recession curves. We present analyses of simultaneous discharge and water level time series of two distinctly different karst systems, one with low porosity and permeability matrix rocks in southern France, and one with high porosity and permeability matrix rocks in north-central Florida (USA). We apply simple mathematical models of flood recession using time series representations of recharge, storage, and discharge processes in the karst aquifer. We show that karst spring hydrographs can be interpreted according to pressure transfer between two distinct components of the aquifer, conduit and matrix porosity, which induce two distinct responses at the spring. Water exchange between conduits and matrix porosity successively control the flow regime at the spring. This exchange is governed by hydraulic head differences between conduits and matrix, head gradients within conduits, and the contrast of permeability between conduits and matrix. These observations have consequences for physical interpretations of recession curves and modeling of karst spring flows, particularly for the relative magnitudes of base flow and quick flow from karst springs. Finally, these results suggest that similar analyses of recession curves can be applied to karst aquifers with distinct physical characteristics utilizing well and spring hydrograph data, but information must be known about the hydrodynamics and physical properties of

  7. Modified conduit preparation creates a pseudosinus in an aortic valve-sparing procedure for aneurysm of the ascending aorta.

    Science.gov (United States)

    Cochran, R P; Kunzelman, K S; Eddy, A C; Hofer, B O; Verrier, E D

    1995-06-01

    Mechanical valved conduit replacement of the aortic root is a durable and appropriate procedure for many diseases of the ascending aorta, but may sacrifice an anatomically salvageable aortic valve. For young active patients and for patients with "systemic" arterial disease (atherosclerosis, Marfan's syndrome) who may require future operations, life-long anticoagulation with its attendant thromboembolic versus hemorrhagic risks is not ideal. Several techniques have been suggested as aortic valve-sparing options. Recently, a procedure was described that combines the freehand homograft techniques with the standard Bentall techniques (David procedure). This innovative technique replaces the ascending aorta with a Dacron cylinder, spares the aortic valve, and restores competence and thus offers an excellent alternative. The durability of this procedure that places the aortic valve inside a cylindrical conduit without sinuses of Valsalva is unknown. In selected patients, we have used this technique to spare the aortic valve. On the basis of experimental data and preliminary computer modeling, with the hope of improving the durability, we have modified the conduit to create a "pseudosinus" in our most recent nine patients. We have done the David procedure in 10 patients. The pseudosinus modification was done in the most recent nine patients. Patients' ages ranged from 37 to 71 years (mean 49.9 years). There were five female and five male patients. Five patients had Marfan's syndrome and five patients had annuloaortic ectasia. There has been no mortality and all patients have had both early and late follow-up echocardiography. Five patients have zero to trace aortic insufficiency, four patients have trace to mild aortic insufficiency, and one patient has mild or "1+" aortic insufficiency. Aortic insufficiency has not progressed in any patient during the 18 months of follow-up. The patient with 1+ aortic insufficiency has no activity limits, good ventricular function, and

  8. Enantioselektivität und Isotopendiskriminierung - Zur Analytik von 1,2-Propandiol und 4-Hydroxy-2,5-dimethyl-3(2H)-furanon (Furaneol)

    OpenAIRE

    Hartlieb, Ariane

    2009-01-01

    Aussagekräftige Methoden zur Authentizitätsbewertung sind unerlässlich, um so-wohl einen fairen Handel als auch das Vertrauen der Verbraucher in die Qualität von Lebensmitteln zu gewährleisten. Das Ziel dieser Arbeit war es, anhand der Parameter 'Enantioselektivität' und 'Iso-topendiskriminierung' Methoden zur Authentizitätskontrolle von Schaumweinen und Erdbeeren, beides Produkte mit einem vergleichsweise hohen Handelswert, zur Verfügung zu stellen. Um unmittelbare Anwendbarkeit in der Praxi...

  9. Uses of continuous measuring techniques for optimizing the operation of municipal sewage treatment plants; Einsatzmoeglichkeiten kontinuierlicher Messtechnik zur Betriebsoptimierung kommunaler Klaeranlagen

    Energy Technology Data Exchange (ETDEWEB)

    Wedi, D [Vermicon AG, Muenchen/Braunschweig (Germany)

    1998-12-31

    Three different optimization measures are briefly discussed, each of which was carried out with the support of continuous measurements: efforts to enhance the sedimentation performance of a final sedimentation tank, investigations to establish the nitrification performance of an existing plant, and measurements permitting optimized parametrization of the complex control of a new sewage treatement plant. (orig./SR) [Deutsch] Es werden drei verschiedene Optimierungsmassnahmen kurz erlaeutert, die jeweils mit Unterstutzung kontinuierlicher Messungen erfolgten: Arbeiten zur Verbesserung der Sedimentationsleistung eines Nachklaerbeckens, Untersuchungen zur besseren Nachrechnung der Nitrifikationskapazitaet einer bestehenden Anlage und Messungen zur optimierten Parametrierung einer komplexeren Regelung einer neuen Klaeranlage. (orig./SR)

  10. Medien – Generationen – Wissen. Überlegungen zur medienpädagogischen Forschung – dargestellt am Beispiel der Frage nach dem Weltwissen globaler Mediengenerationen

    Directory of Open Access Journals (Sweden)

    Theo Hug

    2017-07-01

    Full Text Available Mit den aktuellen gesellschaftlichen, technologischen und politischen Entwicklungen haben sich neue Fragen und Aufgabenbereiche für die Medienpädagogik ergeben. Diese werden im vorliegenden Beitrag skizziert, wobei in Abgrenzung von traditionellen Auffassungen für ein weiteres Verständnis von Medienpädagogik argumentiert wird. Die Erweiterung des thematischen Horizonts wird anhand einer Pilotstudie zur Frage des Weltwissens von Mediengenerationen exemplarisch verdeutlicht. Abschließend werden einige Überlegungen zur Medienkompetenz, der Problematik diesbezüglicher Verkürzungen und deren Stellenwert im Lichte des „medial turn“ zur Diskussion gestellt.

  11. Uses of continuous measuring techniques for optimizing the operation of municipal sewage treatment plants; Einsatzmoeglichkeiten kontinuierlicher Messtechnik zur Betriebsoptimierung kommunaler Klaeranlagen

    Energy Technology Data Exchange (ETDEWEB)

    Wedi, D. [Vermicon AG, Muenchen/Braunschweig (Germany)

    1997-12-31

    Three different optimization measures are briefly discussed, each of which was carried out with the support of continuous measurements: efforts to enhance the sedimentation performance of a final sedimentation tank, investigations to establish the nitrification performance of an existing plant, and measurements permitting optimized parametrization of the complex control of a new sewage treatement plant. (orig./SR) [Deutsch] Es werden drei verschiedene Optimierungsmassnahmen kurz erlaeutert, die jeweils mit Unterstutzung kontinuierlicher Messungen erfolgten: Arbeiten zur Verbesserung der Sedimentationsleistung eines Nachklaerbeckens, Untersuchungen zur besseren Nachrechnung der Nitrifikationskapazitaet einer bestehenden Anlage und Messungen zur optimierten Parametrierung einer komplexeren Regelung einer neuen Klaeranlage. (orig./SR)

  12. Comparative analysis of the pressure profilometry of vesicocutaneous continent catheterizable conduits between patients with and without rectus abdominis neosphincter (Yachia principle).

    Science.gov (United States)

    Rondon, Atila; Leslie, Bruno; Arcuri, Leonardo Javier; Ortiz, Valdemar; Macedo, Antonio

    2015-09-01

    To assess whether crossing rectus abdominis muscle strips, as proposed by Yachia, would change urinary catheterizable conduit's pressure profilometry, in static and dynamic conditions. Non-randomized selection of 20 continent patients that underwent Macedo's ileum-based reservoir, 10 including Yachia's technique (Study Group) and 10 without this mechanism of continence (Control Group). Demographics and cystometric data were assessed. Conduit's pressure profilometry was obtained by infusing saline through a multichannel catheter, at rest and during Valsalva maneuver. We assessed the pressure: (a) in the bladder; (b) in conduit's proximal segment; and (c) in conduit's distal segment, which is presumably the abdominal wall and crossed muscle strips site. Mean age at surgery was 6.1 years in the Control Group and 7.7 years in the Study Group. There was no statistically significant difference between groups regarding maximum cystometric bladder capacity and leakage point pressure. At rest, the pressure profilometry showed similar results between groups in all segments analyzed. During Valsalva maneuver, pressure profilometry showed similar results between groups in bladder and conduit's proximal segment pressure. In this condition, conduit's distal segment pressure in the Study Group (Mean = 72.9 and Peak = 128.7 cmH2 O) was significantly greater (P continence. © 2014 Wiley Periodicals, Inc.

  13. Magmas in motion: Degassing in volcanic conduits and fabrics of pyroclastic density current

    Science.gov (United States)

    Burgisser, Alain

    Volcanoes are caused by the transport of magma batches from the Earth's crust to the surface. These magmas in motion undergo drastic changes of rheologic properties during their journey to the surface and this work explores how these changes affect volcanic eruptions. The first part of this study is devoted to the dynamic aspects of degassing and permeability in magmas with high pressure, high temperature experiments on natural volcanic rocks. Degassing is measured by the influence of decompression rate on the growth of the bubbles present in the magma while permeability is deduced from the temporal evolution of these bubbles. The parameterization of our results in a numerical model of volcanic conduit flow show that previous models based on equilibrium degassing overestimate the acceleration and the decompression rate of the magma. Assessing permeability effects derived form our results show that the transition between explosive and effusive eruptions is a strong function of the magma initial ascent rate. The second part of this work is a unification of two end-members of pyroclastic currents (highly concentrated pyroclastic flows and dilute, turbulent pyroclastic surges) using theoretical scaling arguments based on multiphase physics. Starting from the dynamics of the particle interactions with a fundamental eddy, we consider the full spectrum of eddies generated within a turbulent current. We demonstrate that the presence of particles with various sizes induces a density stratification of the current, leading to its segregation into a basal concentrated part overlain by a dilute cloud. To verify our predictions on the interactions of such a segregated pyroclastic current with its surroundings (hills and sea), we studied the products of the 2050 BP caldera-forming eruption of Okmok Volcano (Alaska). This field study allowed us to reconstruct the eruptive sequence and to validate the main aspects of our theoretical model, such as the superposition of a dense and

  14. Speleogenesis, geometry, and topology of caves: A quantitative study of 3D karst conduits

    Science.gov (United States)

    Jouves, Johan; Viseur, Sophie; Arfib, Bruno; Baudement, Cécile; Camus, Hubert; Collon, Pauline; Guglielmi, Yves

    2017-12-01

    Karst systems are hierarchically spatially organized three-dimensional (3D) networks of conduits behaving as drains for groundwater flow. Recently, geostatistical approaches proposed to generate karst networks from data and parameters stemming from analogous observed karst features. Other studies have qualitatively highlighted relationships between speleogenetic processes and cave patterns. However, few studies have been performed to quantitatively define these relationships. This paper reports a quantitative study of cave geometries and topologies that takes the underlying speleogenetic processes into account. In order to study the spatial organization of caves, a 3D numerical database was built from 26 caves, corresponding to 621 km of cumulative cave passages representative of the variety of karst network patterns. The database includes 3D speleological surveys for which the speleogenetic context is known, allowing the polygenic karst networks to be divided into 48 monogenic cave samples and classified into four cave patterns: vadose branchwork (VB), water-table cave (WTC), looping cave (LC), and angular maze (AM). Eight morphometric cave descriptors were calculated, four geometrical parameters (width-height ratio, tortuosity, curvature, and vertical index) and four topological ones (degree of node connectivity, α and γ graph indices, and ramification index) respectively. The results were validated by statistical analyses (Kruskal-Wallis test and PCA). The VB patterns are clearly distinct from AM ones and from a third group including WTC and LC. A quantitative database of cave morphology characteristics is provided, depending on their speleogenetic processes. These characteristics can be used to constrain and/or validate 3D geostatistical simulations. This study shows how important it is to relate the geometry and connectivity of cave networks to recharge and flow processes. Conversely, the approach developed here provides proxies to estimate the evolution of

  15. The role of external drains and peritoneal conduits in the treatment of recurrent chronic subdural hematoma.

    Science.gov (United States)

    Santarius, Thomas; Qureshi, Hammad U; Sivakumaran, Ram; Kirkpatrick, Peter J; Kirollos, Ramez W; Hutchinson, Peter J

    2010-06-01

    A considerable body of evidence supporting the use of external drainage after evacuation of primary chronic subdural hematoma (CSDH) exists in the literature. However, no systematic study of the value of postoperative drainage in the treatment of recurrent CSDH has been published. The aim of the study was to investigate external drains and subdural-to-peritoneal conduit in the treatment of recurrent CSDH. A retrospective review of cases of CSDH treated in our institution between October 2002 and October 2006 was conducted. During the study period, 408 patients had burr hole evacuation. Sixty-four patients (15.9%) had treatment for recurrence. One patient had craniotomy, and the remaining 63 had another burr hole evacuation: 36 without placement of a drain (BHO), 14 with external drainage (SED), and 13 with placement of subdural-peritoneal catheter (SPC). Fifteen patients (24%) developed a secondary recurrence requiring a third drainage procedure. Postoperative drainage (SED or SPC) was associated with a significantly lower secondary recurrence rate when compared to BHO: 3/27 (11%) versus 12/36 (33%) (χ(2), P=.040). There was no significant difference in recurrence rates between SED and SPC. Postoperative complications included acute subdural hematoma (2), subdural empyema (2), brain edema (2), pneumonia (3), and in-hospital death (2). None of the complications was associated with the use of a specific technique. The results indicate that, as in the treatment of primary CSDHs, the use of drain (SED or SPC) with burr hole evacuation is safe and is associated with lower recurrence rate. Further investigation is needed to clarify the indications of currently available surgical techniques in the treatment of recurrent CSDH. Copyright © 2010 Elsevier Inc. All rights reserved.

  16. Quantitative Analysis of Karst Conduit Structure Parameters and Hydraulic Parameters Based on Tracer Test

    Science.gov (United States)

    Qiang, Z.; Zhiqiang, Z.; Xu, M.; Jinyu, S.; Jihong, Q.

    2017-12-01

    The Old Town of Lijiang is famous as the world cultural heritage since 1997, while characterized by its ancient buildings and natural scenery, water is the soul of the town. Around Heilongtan Springs, there are a large quantity of springs at the Old Town of Lijiang , which is an important part of the World Cultural Heritage. Heilongtan Springs is 2420m above the sea level, the annual variation of the flow rate varies greatly (0 8042 x 104 m3 / year). Recharge area Jiuzihai depressions is 6km long, 3km wide and 2800m above sea level, as main karst water recharge area karst funnel and the sink hole are developing on this planation surface, in the research area medium to thick layers of limestone made up Beiya formation (T2b) of Triassic system distributed widely, karst is strongly developed and the fissure caves water occurrence. In order to exploring the application of tracer test in karst hydrogeology, a tracer test was conducted from Jiuzihai depressions to Ganze Spring. Based on the hydrogeological conditions in the study area, tracer test was used for analysis of groundwater connectivity and flow field characteristics, quantitative analysis of Tracer Breakthrough Curves (BTC) with code Qtracer2. The results demonstated that there are hydraulic connection between Jiuzihai depressions with Ganze Spring, and there are other karst conduits in this area. The longitudinal dispersivity coefficient is 0.24 m2/s, longitudinal dispersivity is 12.06m, flow-channel volume is 3.08×104 m3, flow-channel surface area is 3.27×107m2, mean diameter is 1.42m, Reynolds number is 25187, Froude number is 0.0061, respectively. The groundwater in this area is in a slow turbulent state. The results are of great significance to understand the law of groundwater migration, establish groundwater quality prediction model and exploit karst water resources effectively.

  17. Dependence of the ac loss on the aspect ratio in a cable in conduit conductor

    International Nuclear Information System (INIS)

    Cau, F; Bruzzone, P

    2010-01-01

    The coupling current loss in rectangular superconducting cables is strictly dependent on their aspect ratio, which has an impact on the area linked by the field variation and consequently on the currents induced between strands. The relation between the ac loss and aspect ratio is studied with reference to the testing of three short cable in conduit conductor (CICC) samples at the SULTAN test facility. The first conductor is a 25 kA NbTi cable for the JT60-SA tokamak; the second is a 20 kA Nb 3 Sn cable for the HZB hybrid magnet. The last CICC is a 68 kA Nb 3 Sn cable with layout similar to that of the ITER toroidal field (TF) conductor (called the 'European toroidal field (EUTF) alternate'). All the samples are assembled with two conductor sections differing only in their orientation with respect to the external variable field. In the first and third samples, the cable of one leg is rotated by 90 0 , while in the HZB sample it is rotated by 45 0 with respect to the other leg. The ac loss is measured at the SULTAN test facility using a gas flow calorimetric method. A sample length of 39 cm is exposed to a sinusoidal field with an amplitude of ± 0.3 or ± 0.2 T (depending on the superconductor) and frequency variable in the range 0.1-0.8 Hz. A background field of 2 T perpendicular both to the sinusoidal field and to the sample axis is also applied. The ac loss is assessed by measuring the variation of the He enthalpy, assuming the metal enthalpy to be negligible. The loss curve for both legs is discussed in terms of the respective aspect ratios and the results, including data from former test campaigns, are compared with the aim of finding an analytical relation between the loss and the conductor dimensions.

  18. Nanopatterned acellular valve conduits drive the commitment of blood-derived multipotent cells

    Directory of Open Access Journals (Sweden)

    Di Liddo R

    2016-10-01

    Full Text Available Rosa Di Liddo,1,2 Paola Aguiari,3 Silvia Barbon,1,2 Thomas Bertalot,1 Amit Mandoli,1 Alessia Tasso,1 Sandra Schrenk,1 Laura Iop,3 Alessandro Gandaglia,3 Pier Paolo Parnigotto,2 Maria Teresa Conconi,1,2 Gino Gerosa31Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 2Foundation for Biology and Regenerative Medicine, Tissue Engineering and Signaling ONLUS, 3Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy Abstract: Considerable progress has been made in recent years toward elucidating the correlation among nanoscale topography, mechanical properties, and biological behavior of cardiac valve substitutes. Porcine TriCol scaffolds are promising valve tissue engineering matrices with demonstrated self-repopulation potentiality. In order to define an in vitro model for investigating the influence of extracellular matrix signaling on the growth pattern of colonizing blood-derived cells, we cultured circulating multipotent cells (CMC on acellular aortic (AVL and pulmonary (PVL valve conduits prepared with TriCol method and under no-flow condition. Isolated by our group from Vietnamese pigs before heart valve prosthetic implantation, porcine CMC revealed high proliferative abilities, three-lineage differentiative potential, and distinct hematopoietic/endothelial and mesenchymal properties. Their interaction with valve extracellular matrix nanostructures boosted differential messenger RNA expression pattern and morphologic features on AVL compared to PVL, while promoting on both matrices the commitment to valvular and endothelial cell-like phenotypes. Based on their origin from peripheral blood, porcine CMC are hypothesized in vivo to exert a pivotal role to homeostatically replenish valve cells and contribute to hetero- or allograft colonization. Furthermore, due to their high responsivity to extracellular matrix nanostructure signaling, porcine CMC could be useful for a preliminary

  19. Spatial resolution of transport parameters in a subtropical karst conduit system during dry and wet seasons

    Science.gov (United States)

    Ender, Anna; Goeppert, Nadine; Goldscheider, Nico

    2018-04-01

    Karst aquifers are characterized by a high degree of hydrologic variability and spatial heterogeneity of transport parameters. Tracer tests allow the quantification of these parameters, but conventional point-to-point experiments fail to capture spatiotemporal variations of flow and transport. The goal of this study was to elucidate the spatial distribution of transport parameters in a karst conduit system at different flow conditions. Therefore, six tracer tests were conducted in an active and accessible cave system in Vietnam during dry and wet seasons. Injections and monitoring were done at five sites along the flow system: a swallow hole, two sites inside the cave, and two springs draining the system. Breakthrough curves (BTCs) were modeled with CXTFIT software using the one-dimensional advection-dispersion model and the two-region nonequilibrium model. In order to obtain transport parameters in the individual sections of the system, a multi-pulse injection approach was used, which was realized by using the BTCs from one section as input functions for the next section. Major findings include: (1) In the entire system, mean flow velocities increase from 183 to 1,043 m/h with increasing discharge, while (2) the proportion of immobile fluid regions decrease; (3) the lowest dispersivity was found at intermediate discharge; (4) in the individual cave sections, flow velocities decrease along the flow direction, related to decreasing gradients, while (5) dispersivity is highest in the middle section of the cave. The obtained results provide a valuable basis for the development of an adapted water management strategy for a projected water-supply system.

  20. Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries.

    Science.gov (United States)

    Halabi, Carmen M; Broekelmann, Thomas J; Lin, Michelle; Lee, Vivian S; Chu, Mon-Li; Mecham, Robert P

    2017-05-01

    Homozygous or compound heterozygous mutations in fibulin-4 ( FBLN4 ) lead to autosomal recessive cutis laxa type 1B (ARCL1B), a multisystem disorder characterized by significant cardiovascular abnormalities, including abnormal elastin assembly, arterial tortuosity, and aortic aneurysms. We sought to determine the consequences of a human disease-causing mutation in FBLN4 (E57K) on the cardiovascular system and vascular elastic fibers in a mouse model of ARCL1B. Fbln4 E57K/E57K mice were hypertensive and developed arterial elongation, tortuosity, and ascending aortic aneurysms. Smooth muscle cell organization within the arterial wall of large conducting vessels was abnormal, and elastic fibers were fragmented and had a moth-eaten appearance. In contrast, vessel wall structure and elastic fiber integrity were normal in resistance/muscular arteries (renal, mesenteric, and saphenous). Elastin cross-linking and total elastin content were unchanged in large or small arteries, whereas elastic fiber architecture was abnormal in large vessels. While the E57K mutation did not affect Fbln4 mRNA levels, FBLN4 protein was lower in the ascending aorta of mutant animals compared to wild-type arteries but equivalent in mesenteric arteries. We found a differential role of FBLN4 in elastic fiber assembly, where it functions mainly in large conduit arteries. These results suggest that elastin assembly has different requirements depending on vessel type. Normal levels of elastin cross-links in mutant tissue call into question FBLN4's suggested role in mediating lysyl oxidase-elastin interactions. Future studies investigating tissue-specific elastic fiber assembly may lead to novel therapeutic interventions for ARCL1B and other disorders of elastic fiber assembly.

  1. Experimental and theoretical fracture mechanics applied to volcanic conduits and domes

    Science.gov (United States)

    Sammonds, P.; Matthews, C.; Kilburn, C.; Smith, R.; Tuffen, H.; Meredith, P.

    2008-12-01

    We present an integrated modelling and experimental approach to magma deformation and fracture, which we attempt to validate against field observations of seismicity. The importance of fracture processes in magma ascent dynamics and lava dome growth and collapse are apparent from the associated seismicity. Our laboratory experiments have shown that brittle fracture of magma can occur at high temperature and stress conditions prevalent in the shallow volcanic system. Here, we use a fracture mechanics approach to model seismicity preceding volcanic eruptions. Starting with the fracture mechanics concept of a crack in an elastic body, we model crack growth around the volcanic conduit through the processes of crack interactions, leading either to the propagation and linkage of cracks, or crack avoidance and the inhibition of crack propagation. The nature of that interaction is governed by the temperature and plasticity of the magma. We find that fracture mechanics rules can account for the style of seismicity preceding eruptions. We have derived the changes in seismic b-value predicted by the model and interpret these in terms of the style of fracturing, fluid flow and heat transport. We compare our model with results from our laboratory experiments where we have deformed lava at high temperatures under triaxial stresses. These experiments were conducted in dry and water saturated conditions at effective pressures up to 10 MPa, temperatures up to 1000°C and strain rates from 10-4 s-1 to 10-6 s-1. The behaviour of these magmas was largely brittle under these conditions. We monitored the acoustic emission emitted and calculate the change in micro-seismic b-value with deformation. These we find are in accord with volcano seismicity and our fracture mechanics model.

  2. Time scales of foam stability in shallow conduits: Insights from analogue experiments

    Science.gov (United States)

    Spina, L.; Scheu, B.; Cimarelli, C.; Arciniega-Ceballos, A.; Dingwell, D. B.

    2016-10-01

    Volcanic systems can exhibit periodical trends in degassing activity, characterized by a wide range of time scales. Understanding the dynamics that control such periodic behavior can provide a picture of the processes occurring in the feeding system. Toward this end, we analyzed the periodicity of outgassing in a series of decompression experiments performed on analogue material (argon-saturated silicone oil plus glass beads/fibers) scaled to serve as models of basaltic magma. To define the effects of liquid viscosity and crystal content on the time scale of outgassing, we investigated both: (1) pure liquid systems, at differing viscosities (100 and 1000 Pa s), and (2) particle-bearing suspensions (diluted and semidiluted). The results indicate that under dynamic conditions (e.g., decompressive bubble growth and fluid ascent within the conduit), the periodicity of foam disruption may be up to several orders of magnitude less than estimates based on the analysis of static conditions. This difference in foam disruption time scale is inferred to result from the contribution of bubble shear and bubble growth to inter-bubble film thinning. The presence of particles in the semidiluted regime is further linked to shorter bubble bursting times, likely resulting from contributions of the presence of a solid network and coalescence processes to the relative increase in bubble breakup rates. Finally, it is argued that these experiments represent a good analogue of gas-piston activity (i.e., the periodical rise-and-fall of a basaltic lava lake surface), implying a dominant role for shallow foam accumulation as a source process for these phenomena.

  3. Von neuen Geschäftsideen zur gelebten Digitalisierung in Utility 4.0 - das Integrierte Geschäftsmodell

    Science.gov (United States)

    Doleski, Oliver D.

    Die Energiewirtschaft benötigt neue, digitale Geschäftsmodelle. Gegenwärtig folgt auf Liberalisierung und Energiewende die nächste Stufe einer weitreichenden Bereinigung des Versorgungsmarktes. Digitalisierung und Dezentralisierung sind heute in aller Munde und verlangen nach neuen Produkten und Dienstleistungen. Dabei wirken die immensen Herausforderungen einer digitalen Energiewelt wie Beschleuniger für die Transformation im Versorgungssektor und tragen damit zur breiten Etablierung von Utilities 4.0 bei. Dieser Entwicklungsprozess vollzieht sich mithilfe unterschiedlicher Methoden zur Realisierung neuer Geschäftsideen. Allerdings greifen die gängigen Konzepte zur Entwicklung von Geschäftsmodellen gerade im Hinblick auf die Berücksichtigung komplexer, unbeständiger Rahmenbedingungen und spezifischer Anforderungen der digitalen Energiewelt mitunter zu kurz. Vor diesem Hintergrund wird das auf dem ganzheitlichen St. Galler Management-Konzept beruhende Integrierte Geschäftsmodell iOcTen als geeignetes Instrumentarium zur Geschäftsmodellentwicklung vorgestellt. Neben der Modellbeschreibung unterstützt ein intuitiv verständlicher Leitfaden den Praktiker bei der Transformation vom klassischen Versorgungsunternehmen zum digitalen Energiedienstleistungsunternehmen.

  4. [Heinz von zur Mühlen. Das Bürgertum Fordert Blut. Ein Bolschewistiches Flugblatt von 1918] / Paul Kaegbein

    Index Scriptorium Estoniae

    Kaegbein, Paul

    2007-01-01

    Arvustus: Heinz von zur Mühlen. Das Bürgertum Fordert Blut. Ein Bolschewistiches Flugblatt von 1918. In : Ostseeprovinzen, baltische Staaten und das Nationale. Münster : LIT, 2005, lk. 403-414. 1918. aastast pärit lendlehest, mille käekirja järgi otsustades on kirjutanud Viktor Kingissepp

  5. [Heinz von zur Mühlen. Paul Johansen und die Sogenannten Undeutschen in Reval/Tallinn] / Paul Kaegbein

    Index Scriptorium Estoniae

    Kaegbein, Paul

    2008-01-01

    Arvustus: Heinz von zur Mühlen. Paul Johansen und die Sogenannten Undeutschen in Reval/Tallinn. - Nordosteuropa als Geschichtsregion. Helsinki : Aue-Stiftung :; Lübeck : Schmidt-Römhild, 2006. lk. 103-111. Paul Johanseni lähim töökaaslane kirjeldab teose "Deutsch und Undeutsch im mittelalterlichen und frühneuzeitlichen Reval" valmimist

  6. Identifikationsverfahren zur Analyse von EEG-Signalen bei Epilepsie mit Reaktions-Diffusions Netzwerken

    Science.gov (United States)

    Gollas, F.; Tetzlaff, R.

    2007-06-01

    Partielle Differentialgleichungen des Reaktions-Diffusions-Typs beschreiben Phänomene wie Musterbildung, nichtlineare Wellenausbreitung und deterministisches Chaos und werden oft zur Untersuchung komplexer Vorgänge auf den Gebieten der Biologie, Chemie und Physik herangezogen. Zellulare Nichtlineare Netzwerke (CNN) sind eine räumliche Anordnung vergleichsweise einfacher dynamischer Systeme, die eine lokale Kopplung untereinander aufweisen. Durch eine Diskretisierung der Ortsvariablen können Reaktions-Diffusions-Gleichungen häufig auf CNN mit nichtlinearen Gewichtsfunktionen abgebildet werden. Die resultierenden Reaktions-Diffusions-CNN (RD-CNN) weisen dann in ihrer Dynamik näherungsweise gleiches Verhalten wie die zugrunde gelegten Reaktions-Diffusions-Systeme auf. Werden RD-CNN zur Identifikation neuronaler Strukturen anhand von EEG-Signalen herangezogen, so besteht die Möglichkeit festzustellen, ob das gefundene Netzwerk lokale Aktivität aufweist. Die von Chua eingeführte Theorie der lokalen Aktivität Chua (1998); Dogaru und Chua (1998) liefert eine notwendige Bedingung für das Auftreten von emergentem Verhalten in zellularen Netzwerken. Änderungen in den Parametern bestimmter RD-CNN könnten auf bevorstehende epileptische Anfälle hinweisen. In diesem Beitrag steht die Identifikation neuronaler Strukturen anhand von EEG-Signalen durch Reaktions-Diffusions-Netzwerke im Vordergrund der dargestellten Untersuchungen. In der Ergebnisdiskussion wird insbesondere auch die Frage nach einer geeigneten Netzwerkstruktur mit minimaler Komplexität behandelt.

  7. Vertebroplasty in the treatment of back pain; Vertebroplastie zur Therapie des Rueckenschmerzes

    Energy Technology Data Exchange (ETDEWEB)

    Trumm, C.G.; Jakobs, T.F.; Zech, C.J.; Weber, C.; Reiser, M.F.; Hoffmann, R.T. [Klinikum Grosshadern der Ludwig-Maximilians-Universitaet, Institut fuer Klinische Radiologie, Muenchen (Germany)

    2006-06-15

    Beitrag sollen Indikationsstellung, periinterventionelle Bildgebung, Technik und klinische Ergebnisse der PVP dargestellt werden. Gemaess dem ''Interdisziplinaeren Konsensuspapier zur Vertebro- und Kyphoplastie'' der deutschen Fachgesellschaften sowie den Leitlinien der CIRSE aus dem Jahr 2005 werden die aktuellen Richtlinien zur Durchfuehrung der PVP erlaeutert. Die Ergebnisse einer eigenen Studie werden Komplikationsraten und klinischen Ergebnissen in der Literatur gegenuebergestellt. Die Indikation zur PVP besteht bei schmerzhaften osteoporotischen WKF und Wirbelkoerperosteolysen durch Metastasen und das multiple Myelom. Absolute Kontraindikationen sind v. a. asymptomatische WKF, eine Beschwerdelinderung unter medikamentoeser Therapie, therapierefraktaere Koagulopathien, Allergien gegen Zementbestandteile und aktive Infektionen. Zur Abschaetzung des Frakturalters, Ausschluss anderer Schmerzursachen und Beurteilung der Wirbelkoerperhinterkante sind vor der PVP eine MRT bzw. CT indiziert. Eine qualitativ hochwertige mono- oder biplanare Fluoroskopie - moeglichst in Kombination mit der CT(-Fluoroskopie) - sind bei der PVP erforderlich, um das Risiko von Zementleckagen zu minimieren. Bei 86-92% der Patienten wird durch die PVP eine deutliche Schmerzreduktion (mittlere Abnahme von 6,1 Punkten [VAS]) erreicht. Eine eigene Studie mit 58 behandelten Patienten (mittlerer Beobachtungszeitraum 323+/-99 Tage) zeigte in 77% der Faelle eine deutliche Beschwerdelinderung (-5,7 Punkte [VAS]). Die PVP ermoeglicht bei akutem und chronischem Rueckenschmerz durch osteoporotische WKF und tumorbedingte Osteolysen eine sichere und effektive minimalinvasive Therapie zur Stabilisierung und Schmerzreduktion. (orig.)

  8. Studies on agglomeration of colloidal suspensions in an alternating electric field; Untersuchungen zur Agglomeration kolloidaler Suspensionen im elektrischen Wechselfeld

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, M. [Inst. fuer Mechanische Verfahrenstechnik und Mechanik, Univ. Karlsruhe (Germany); Loeffler, F. [Inst. fuer Mechanische Verfahrenstechnik und Mechanik, Univ. Karlsruhe (Germany)

    1996-07-01

    Colloidal solutions contain particles in the {mu}m range whose agglomeration and coagulation is of interest for certain applications. `Electrocoagulation` means that in an electric field droplets or particles in a disperse phase have higher kinetic energy so that the probability of overcoming repulsive forces and of forming bigger aggregates will increase. The electrocoagulation technique is applied for emulsion cracking of water-in-oil systems (desalination and dewatering of petroleum, petroleum cracking) and, in some cases, also for cracking oil-in-water systems. Removal of colloidal solids from aqueous solution during electrochemical waste water treatment is often carried out with the aid of dissolving aluminium or iron electrodes. The authors describe experiments in which the flow of an electric current, which would cause the electrodes to dissolve, was to be prevented. An alternating field was to induce oscillation of the particles, i.e. relative motion of the particles with respect to each other. (orig./SR) [Deutsch] Kolloidale Loesungen enthalten Partikel im {mu}m-Bereich. In manchen Bereichen ist deren Agglomeration bzw. Koagulation von Interesse. Unter dem Begriff der Elektrokoagulation versteht man im allgemeinen das Phaenomen, dass in einem elektrischen Feld Tropfen oder Partikel in einer dispersen Phase eine hoehere kinetische Energie besitzen, und dadurch die Wahrscheinlichkeit zur Ueberwindung von Abstossungskraeften und zur Bildung groesserer Aggregate steigt. Das Verfahren der Elektrokoagulation wird bisher zur Emulsionsspaltung von Wasser/Oel-Systemen (Entsaltzung und Entwaesserung von Erdoel/Erdoelspaltung) und z.T. auch zur Spaltung von Oel/Wasser-Systemen eingesetzt. Zur Entfernung kolloidaler Feststoffe aus waessrigen Loesungen bei der elektrochemischen Aufarbeitung von Abwasser wird haeufig mit sich aufloesenden Aluminium- oder Eisenelektroden gearbeitet. In den im folgenden dargestellten Untersuchungen sollte ein Stromfluss durch die

  9. The Malnutrition-Related Increase in Early Visceralization of Leishmania donovani Is Associated with a Reduced Number of Lymph Node Phagocytes and Altered Conduit System Flow

    Science.gov (United States)

    Ibrahim, Marwa K.; Barnes, Jeffrey L.; Anstead, Gregory M.; Jimenez, Fabio; Travi, Bruno L.; Peniche, Alex G.; Osorio, E. Yaneth; Ahuja, Seema S.; Melby, Peter C.

    2013-01-01

    In a murine model of moderate childhood malnutrition we found that polynutrient deficiency led to a 4–5-fold increase in early visceralization of L. donovani (3 days post-infection) following cutaneous infection and a 16-fold decrease in lymph node barrier function (pmalnutrition-related parasite dissemination we analyzed the cellularity, architecture, and function of the skin-draining lymph node. There was no difference in the localization of multiple cell populations in the lymph node of polynutrient deficient (PND) mice, but there was reduced cellularity with fewer CD11c+dendritic cells (DCs), fibroblastic reticular cells (FRCs), MOMA-2+ macrophages, and CD169+ subcapsular sinus macrophage (p<0.05 for all) compared to the well-nourished (WN) mice. The parasites were equally co-localized with DCs associated with the lymph node conduit network in the WN and PND mice, and were found in the high endothelial venule into which the conduits drain. When a fluorescent low molecular weight (10 kD) dextran was delivered in the skin, there was greater efflux of the marker from the lymph node conduit system to the spleens of PND mice (p<0.04), indicating that flow through the conduit system was altered. There was no evidence of disruption of the conduit or subcapsular sinus architecture, indicating that the movement of parasites into the subcortical conduit region was due to an active process and not from passive movement through a leaking barrier. These results indicate that the impaired capacity of the lymph node to act as a barrier to dissemination of L. donovani infection is associated with a reduced number of lymph node phagocytes, which most likely leads to reduced capture of parasites as they transit through the sinuses and conduit system. PMID:23967356

  10. Characterization and Schwann Cell Seeding of up to 15.0 cm Long Spider Silk Nerve Conduits for Reconstruction of Peripheral Nerve Defects

    Directory of Open Access Journals (Sweden)

    Tim Kornfeld

    2016-11-01

    Full Text Available Nerve reconstruction of extended nerve defect injuries still remains challenging with respect to therapeutic options. The gold standard in nerve surgery is the autologous nerve graft. Due to the limitation of adequate donor nerves, surgical alternatives are needed. Nerve grafts made out of either natural or artificial materials represent this alternative. Several biomaterials are being explored and preclinical and clinical applications are ongoing. Unfortunately, nerve conduits with successful enhancement of axonal regeneration for nerve defects measuring over 4.0 cm are sparse and no conduits are available for nerve defects extending to 10.0 cm. In this study, spider silk nerve conduits seeded with Schwann cells were investigated for in vitro regeneration on defects measuring 4.0 cm, 10.0 cm and 15.0 cm in length. Schwann cells (SCs were isolated, cultured and purified. Cell purity was determined by immunofluorescence. Nerve grafts were constructed out of spider silk from Nephila edulis and decellularized ovine vessels. Finally, spider silk implants were seeded with purified Schwann cells. Cell attachment was observed within the first hour. After 7 and 21 days of culture, immunofluorescence for viability and determination of Schwann cell proliferation and migration throughout the conduits was performed. Analyses revealed that SCs maintained viable (>95% throughout the conduits independent of construct length. SC proliferation on the spider silk was determined from day 7 to day 21 with a proliferation index of 49.42% arithmetically averaged over all conduits. This indicates that spider silk nerve conduits represent a favorable environment for SC attachment, proliferation and distribution over a distance of least 15.0 cm in vitro. Thus spider silk nerve implants are a highly adequate biomaterial for nerve reconstruction.

  11. Sciatic nerve regeneration by transplantation of Schwann cells via erythropoietin controlled-releasing polylactic acid/multiwalled carbon nanotubes/gelatin nanofibrils neural guidance conduit.

    Science.gov (United States)

    Salehi, Majid; Naseri-Nosar, Mahdi; Ebrahimi-Barough, Somayeh; Nourani, Mohammdreza; Khojasteh, Arash; Hamidieh, Amir-Ali; Amani, Amir; Farzamfar, Saeed; Ai, Jafar

    2018-05-01

    The current study aimed to enhance the efficacy of peripheral nerve regeneration using an electrically conductive biodegradable porous neural guidance conduit for transplantation of allogeneic Schwann cells (SCs). The conduit was produced from polylactic acid (PLA), multiwalled carbon nanotubes (MWCNTs), and gelatin nanofibrils (GNFs) coated with the recombinant human erythropoietin-loaded chitosan nanoparticles (rhEpo-CNPs). The PLA/MWCNTs/GNFs/rhEpo-CNPs conduit had the porosity of 85.78 ± 0.70%, the contact angle of 77.65 ± 1.91° and the ultimate tensile strength and compressive modulus of 5.51 ± 0.13 MPa and 2.66 ± 0.34 MPa, respectively. The conduit showed the electrical conductivity of 0.32 S cm -1 and lost about 11% of its weight after 60 days in normal saline. The produced conduit was able to release the rhEpo for at least 2 weeks and exhibited favorable cytocompatibility towards SCs. For functional analysis, the conduit was seeded with 1.5 × 10 4 SCs and implanted into a 10 mm sciatic nerve defect of Wistar rat. After 14 weeks, the results of sciatic functional index, hot plate latency, compound muscle action potential amplitude, weight-loss percentage of wet gastrocnemius muscle and Histopathological examination using hematoxylin-eosin and Luxol fast blue staining demonstrated that the produced conduit had comparable nerve regeneration to the autograft, as the gold standard to bridge the nerve gaps. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1463-1476, 2018. © 2017 Wiley Periodicals, Inc.

  12. Right ventricular to pulmonary artery conduit instead of modified Blalock-Taussig shunt improves postoperative hemodynamics in newborns after the Norwood operation.

    Science.gov (United States)

    Mair, Rudolf; Tulzer, Gerald; Sames, Eva; Gitter, Roland; Lechner, Evelyn; Steiner, Jürgen; Hofer, Anna; Geiselseder, Gertraud; Gross, Christoph

    2003-11-01

    Perioperative mortality, prolonged postoperative recovery after the Norwood procedure, and mortality between stage I and stage II might be related to shunt physiology. A right ventricular to pulmonary artery conduit offers a banded physiology in contrast to a Blalock-Taussig shunt. The purpose of this study was to assess the hemodynamic differences and their consequences in the postoperative course between Norwood patients with a Blalock-Taussig shunt and those with a right ventricular to pulmonary artery conduit. From October 1999 until May 2002, 32 unselected consecutive patients underwent a Norwood procedure at the General Hospital Linz. The first 18 patients received a Blalock-Taussig shunt. In the remaining 14 patients we performed a right ventricular to pulmonary artery conduit. Both groups were compared. The diastolic blood pressure was significantly higher in the right ventricular to pulmonary artery conduit group (P <.001). Despite a higher FIO(2), PO(2) levels tended to be lower in the first 5 postoperative days. At the age of 3 months, catheterization laboratory data showed a lower Qp/Qs ratio in the same group (0.86 [0.78; 1] versus 1.55 [1.15; 1.6]; P =.005) and a higher dp/dt (955 [773; 1110] vs 776 [615; 907]; P =.018). (Descriptive data reflect medians and quartiles [in brackets].) Hospital survival was 72% in the Blalock-Taussig shunt group versus 93% in the right ventricular to pulmonary artery conduit group. Mortality between stage I and stage II was 23% in the Blalock-Taussig shunt group versus 0% in the right ventricular to pulmonary artery conduit group. A higher diastolic blood pressure and a lower Qp/Qs ratio were associated with a more stable and efficient circulation in patients with a right ventricular to pulmonary artery conduit. More intensive ventilatory support was necessary during the first postoperative days. We did not note any adverse effects of the ventriculotomy on ventricular performance.

  13. Formation of obsidian pyroclasts by sintering of ash particles in the volcanic conduit

    Science.gov (United States)

    Gardner, James E.; Llewellin, Edward W.; Watkins, James M.; Befus, Kenneth S.

    2017-02-01

    The ranges in intensity and style of volcanic eruptions, from highly explosive Plinian eruptions to quiescent lava extrusions, depend on the style and efficiency of gas loss from ascending magma. Obsidian pyroclasts - small, glassy pieces of quenched magma found in some volcanic tephra beds - may preserve valuable information about magma degassing in their vesicle textures and volatile contents. Accurate interpretation of their textures and volatiles, however, requires understanding the mechanism of formation of the pyroclasts. Obsidian pyroclasts from the ca. 1325-1350 C.E. North Mono eruption of Mono Craters (CA, USA) were analyzed and found to have H2O and CO2 contents indicating that they were formed at pressures in the approximate range of 3-40 MPa. Many also contain domains with differing vesicle textures, separated by boundaries containing xenocrystic material, indicating that they are composed of smaller fragments that have sutured together. More than half of the pyroclasts analyzed contained small (∼10 μm), highly distorted vesicles, with multi-cuspate morphology, interpreted as the remnants of interstitial gas trapped amongst sintered fragments of melt/glass. Rounded vesicles are also common and are interpreted to result from surface tension-driven relaxation of the distorted vesicles. Calculated timescales of sintering and relaxation are consistent with timescales for pyroclast formation indicated by H2O re-equilibration within the heterogeneous pyroclasts. This sintering model for the origin of obsidian pyroclasts is further supported by the observation that spherical vesicles are found mainly in H2O-rich pyroclasts, and distorted vesicles mainly in H2O-poor pyroclasts. We conclude that obsidian pyroclasts generated during the North Mono eruption were formed by cycles of fragmentation, sintering/suturing, and relaxation, over a very wide range of depths within the conduit; we find no evidence to support pumice (foam) collapse as the formation

  14. Chemistry, mineralogy and alteration intensity of hydrothermal altered Mt Unzen conduit rocks (Shimabara/Japan)

    Science.gov (United States)

    Hess, Kai-Uwe; Yilmaz, Tim; Gilg, H. Albert; Janots, Emilie; Mayer, Klaus; Nakada, Setsuya; Dingwell, Donald

    2017-04-01

    Investigations were carried out on hydrothermally altered coherent dacitic dykes samples from (USDP-4) drill core at Mt Unzen stratovolcano (Shimabara/Japan). XRF, XRD, EMPA, C-O-isotope, hot-cathode CL and SEM analysis led to insights concerning chemistry, mineralogy, and intensity and type of alteration as well as the origin of carbonate-precipitating fluids. Additionally a textural characterization of the occurring replacement features in the volcanic conduit rocks was performed. The occurrence of the main secondary phases such as chlorite, pyrite, carbonates, and R1 (Reichweite parameter) illite-smectite and kaolinite group minerals indicate a weak to moderate propylitic to phyllic hydrothermal alteration. The dacitic samples of the dykes show different hydrothermal alteration features: (i) carbonate and chlorite pseudomorphs after hornblende as well as core and zonal textures due to replacement of plagioclase by R1 illite-smectite as well as kaolinite group minerals, (ii) colloform banded fracture fillings and fillings in dissolution vugs, and (iii) chlorite, R1 illite-smectite as well as kaolinite group minerals in the groundmass. Late chlorite veins crosscut precipitates of R1 illite-smectite as well as kaolinite group minerals. Carbonates in fractures and in pseudomorphs after hornblende comprise iron-rich dolomite solid solutions ("ankerite") and calcite. Isotopic values indicate a hydrothermal-magmatic origin for the carbonate formation. The chlorite-carbonate-pyrite index (CCPI) and the Ishikawa alteration index (AI), applied to the investigated samples show significant differences (CCPI=52.7-57.8; AI=36.1-40.6) indicating their different degree of alteration. According to Nakada et al., 2005, the C13 to C16 dykes represent the feeder dyke from the latest eruption (1991-1995) whereas C8 represents an earlier dyke feeder dyke from an older eruption. Weakest alteration, which was obtained in samples C16-1-5 and C13-2-5, correlates with the alteration

  15. The QBO as potential amplifier and conduit to lower altitudes of solar cycle influence

    Directory of Open Access Journals (Sweden)

    H. G. Mayr

    2007-06-01

    tapping the momentum from the upward propagating gravity waves. Influenced and amplified by wave processes, the QBO thus acts as conduit to transfer to lower altitudes the larger SC variations in the UV absorbed in the mesosphere. Our model produces in the temperature variations of the QBO and EAO measurable SC modulations at polar latitudes near the tropopause. The effects are apparently generated by the meridional circulation, and planetary waves presumably, which redistribute the energy from the equatorial region where the waves are very effective in amplifying the SC influence.

  16. Clean Sampling of an Englacial Conduit at Blood Falls, Antarctica - Some Experimental and Numerical Results

    Science.gov (United States)

    Kowalski, Julia; Francke, Gero; Feldmann, Marco; Espe, Clemens; Heinen, Dirk; Digel, Ilya; Clemens, Joachim; Schüller, Kai; Mikucki, Jill; Tulaczyk, Slawek M.; Pettit, Erin; Berry Lyons, W.; Dachwald, Bernd

    2017-04-01

    results of its deployment at Blood Falls. In contrast to conventional melting-probe applications, which can only melt vertically, the IceMole realized an oblique melting path to penetrate the englacial conduit. Experimental and numerical results on melting at oblique angles are rare. Besides reporting on the IceMole technology and the field deployment itself, we will compare and discuss the observed melting behavior with re-analysis results in the context of a recently developed numerical model. Finally, we will present our first steps in utilizing the model to infer on the ambient cryo-environment.

  17. Untersuchungen zur Expansion, funktionellen Charakterisierung und kontinuierlichen Bereitstellung von Hepatocyten für die Anwendung in bioartifiziellen Leberunterstützungssystemen

    OpenAIRE

    Iding, Kai

    2001-01-01

    Der vollständige Funktionsverlust der Leber kann in der modernen Medizin bisher nur durch den Austausch des funktionsuntüchtigen gegen ein gesundes Organ, d.h. durch eine Lebertransplantation behandelt werden. Da es jedoch weit mehr transplantationsbedürftige Patienten gibt als geeignete Spenderorgane zur Verfügung stehen, gibt es weltweite Anstrengungen zur Entwicklung alternativer Behandlungsmethoden. Nach bisherigem wissenschaftlichen Erkenntnisstand ist die bioartifizielle Leberunterst...

  18. Energy report for Bavaria, 1996/97. Data on the development of the Bavarian energy industry, with an energy balance; Energiebericht Bayern 1996/97. Daten zur Entwicklung der bayerischen Energiewirtschaft mit Energiebilanz

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-04-01

    The report presents the energy balance for Bavaria and provides information on: Bavarian energy industry; structure and development of primary and end-use energy consumption; situation and development of energy sources (electricity, gas, mineral oil, coal, district heating). (orig.) [Deutsch] Der Bericht enthaelt die Energiebilanz Bayern fuer das Berichtsjahr und bietet Informationen zur Energiewirtschaft in Bayern, zur Struktur und Entwicklung des Primaer- und Endenergieverbrauchs und zur Situation und Entwicklung bei den einzelnen Energietraegern (Elektrizitaet, Gas, Mineraloel, Kohle, Fernwaerme). (orig.)

  19. A pilot muon radiography to image the shallow conduit of the Stromboli volcano: results and future prospects

    Science.gov (United States)

    Miyamoto, Seigo; Tioukov, Valeri; Sirignano, Chiara; Bozza, Cristiano; Morishima, Kunihiro

    2017-04-01

    The test result of imaging the shallow part of the Stromboli crater zone by using cosmic-ray muons in 2012 and possible performance of the future muon observation will be presented. It is well known that the behavior of volcanic eruptions strongly depends on the shape of the conduit. Stromboli is one of the most known and studied active volcanoes in the world, nevertheless the details of its internal structure are not well defined yet. Geophysical exploration method which use high energy cosmic-ray muons and makes the density image of the object like X-ray radiography for the human body is called "muon radiography " or "muography". A pilot muography was done for the shallow part of Stromboli in 2012. We succeeded to clarify that there is a less density part at the North-East cone in the crater zone. It is considered that the stack of volcanic ashes. On the other hand, we also confirmed that the contamination of the physical background particles and they makes the noisy density image especially about 50 meter below from the top of the crater. In another observation, Nishiyama et al (2014) revealed the contents of background particles and the way to remove them were presented. They showed that the main contents of the background particles is low kinetic energy charged particles and also showed that it is possible to remove them by using multi-layerd muon film detector. We can plan the future muography observation to see the deeper part of the conduit( at least until 100 meter from the top of crater) by their backgroundless method. Therefore we estimated possible performance of the future observation by multi-layer muon films. The result suggests that we might get the image of shallow conduit from the surface to the depth of e.g. 55 meter with 20 meter spatial resolution or 100 meter with 27 meter resolution in case the density in the conduit is 0.0 g/cm3 and with 71 percent statistical confidence level.

  20. Construction of nerve guide conduits from cellulose/soy protein composite membranes combined with Schwann cells and pyrroloquinoline quinone for the repair of peripheral nerve defect

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Lihua [Department of Biomedical Engineering, School of Basic Medical Sciences, Wuhan University, Wuhan 430071 (China); Center of Molecular Medicine, School of Medicine, Hubei University of Arts and Sciences, Xiangyang 441053 (China); Gan, Li; Liu, Yongming; Tian, Weiqun; Tong, Zan [Department of Biomedical Engineering, School of Basic Medical Sciences, Wuhan University, Wuhan 430071 (China); Wang, Xiong; Huselstein, Celine [Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), UMR 7365 CNRS – Université de Lorraine, Biopôle, 54500 Vandoeuvre-lès-Nancy (France); Chen, Yun, E-mail: yunchen@whu.edu.cn [Department of Biomedical Engineering, School of Basic Medical Sciences, Wuhan University, Wuhan 430071 (China)

    2015-02-20

    Regeneration and functional reconstruction of peripheral nerve defects remained a significant clinical challenge. Nerve guide conduits, with seed cells or neurotrophic factors (NTFs), had been widely used to improve the repair and regeneration of injured peripheral nerve. Pyrroloquinoline quinone (PQQ) was an antioxidant that can stimulate nerve growth factors (NGFs) synthesis and accelerate the Schwann cells (SCs) proliferation and growth. In present study, three kinds of nerve guide conduits were constructed: one from cellulose/SPI hollow tube (CSC), another from CSC combined with SCs (CSSC), and the third one from CSSC combined with PQQ (CSSPC), respectively. And then they were applied to bridge and repair the sciatic nerve defect in rats, using autograft as control. Effects of different nerve guide conduits on the nerve regeneration were comparatively evaluated by general analysis, sciatic function index (SFI) and histological analysis (HE and TEM). Newly-formed regenerative nerve fibers were observed and running through the transparent nerve guide conduits 12 weeks after surgery. SFI results indicated that the reconstruction of motor function in CSSPC group was better than that in CSSC and CSC groups. HE images from the cross-sections and longitudinal-sections of the harvested regenerative nerve indicated that regenerative nerve fibers had been formed and accompanied with new blood vessels and matrix materials in the conduits. TEM images also showed that lots of fresh myelinated and non-myelinated nerve fibers had been formed. Parts of vacuolar, swollen and abnormal axons occurred in CSC and CSSC groups, while the vacuolization and swell of axons was the least serious in CSSPC group. These results indicated that CSSPC group had the most ability to repair and reconstruct the nerve structure and functions due to the comprehensive contributions from hollow CSC tube, SCs and PQQ. As a result, the CSSPC may have the potential for the applications as nerve guide

  1. Three-layer microfibrous peripheral nerve guide conduit composed of elastin-laminin mimetic artificial protein and poly(L-lactic acid

    Directory of Open Access Journals (Sweden)

    Sachiro eKakinoki

    2014-07-01

    Full Text Available We developed a microfibrous poly(L-lactic acid (PLLA nerve conduit with a three-layered structure to simultaneously enhance nerve regeneration and prevent adhesion of surrounding tissue. The inner layer was composed of PLLA microfiber containing 25% elastin-laminin mimetic protein (AG73-(VPGIG30 that promotes neurite outgrowth. The thickest middle layer was constructed of pure PLLA microfibers that impart the large mechanical stremgth to the conduit. A 10% poly(ethylene glycol was added to the outer layer to prevent the adhesion with the surrounding tissue. The AG73-(VPGIG30 composisting of an elastin-like repetitive sequence (VPGIG30 and a laminin-derived sequence (RKRLQVQLSIRT: AG73 was biosynthesized using Escherichia coli. The PLLA microfibrous conduits were fabricated using an electrospinning procedure. AG73-(VPGIG30 was successfully mixed in the PLLA microfibers, and the PLLA/AG73-(VPGIG30 microfibers were stable under physiological conditions. The PLLA/AG73-(VPGIG30 microfibers enhanced adhesion and neurite outgrowth of PC12 cells. The electrospun microfibrous conduit with a three-layered structure was implanted for bridging a 2.0-cm gap in the tibial nerve of a rabbit. Two months after implantation, no adhesion of surrounding tissue was observed, and the action potential was slightly improved in the nerve conduit with the PLLA/AG73-(VPGIG30 inner layer.

  2. Three-layer microfibrous peripheral nerve guide conduit composed of elastin-laminin mimetic artificial protein and poly(L-lactic acid)

    Science.gov (United States)

    Kakinoki, Sachiro; Nakayama, Midori; Moritan, Toshiyuki; Yamaoka, Tetsuji

    2014-07-01

    We developed a microfibrous poly(L-lactic acid) (PLLA) nerve conduit with a three-layered structure to simultaneously enhance nerve regeneration and prevent adhesion of surrounding tissue. The inner layer was composed of PLLA microfiber containing 25% elastin-laminin mimetic protein (AG73-(VPGIG)30) that promotes neurite outgrowth. The thickest middle layer was constructed of pure PLLA microfibers that impart the large mechanical stremgth to the conduit. A 10% poly(ethylene glycol) was added to the outer layer to prevent the adhesion with the surrounding tissue. The AG73-(VPGIG)30 composisting of an elastin-like repetitive sequence (VPGIG)30 and a laminin-derived sequence (RKRLQVQLSIRT: AG73) was biosynthesized using Escherichia coli. The PLLA microfibrous conduits were fabricated using an electrospinning procedure. AG73-(VPGIG)30 was successfully mixed in the PLLA microfibers, and the PLLA/AG73-(VPGIG)30 microfibers were stable under physiological conditions. The PLLA/AG73-(VPGIG)30 microfibers enhanced adhesion and neurite outgrowth of PC12 cells. The electrospun microfibrous conduit with a three-layered structure was implanted for bridging a 2.0-cm gap in the tibial nerve of a rabbit. Two months after implantation, no adhesion of surrounding tissue was observed, and the action potential was slightly improved in the nerve conduit with the PLLA/AG73-(VPGIG)30 inner layer.

  3. Opportunities for Energy Development in Water Conduits: A Report Prepared in Response to Section 7 of the Hydropower Regulatory Efficiency Act of 2013

    Energy Technology Data Exchange (ETDEWEB)

    Sale, Michael J. [BCS, Incorporated, Laurel, MD (United States); Bishop, Norman A. [Knight Piesold, Chicago, IL (United States); Reiser, Sonya L. [Knight Piesold, Chicago, IL (United States); Johnson, Kurt [Telluride Energy LLC, Grand Junction, CO (United States); Bailey, Andrea C. [BCS, Incorporated, Laurel, MD (United States); Frank, Anthony [BCS, Incorporated, Laurel, MD (United States); Smith, Brennan T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Environmental Sciences Division

    2014-09-01

    In Section 7 of the Hydropower Regulatory Efficiency Act (HREA) of 2013 (P.L. 113-23), Congress directed the U.S. Department of Energy (DOE) to prepare an analysis of conduit hydropower opportunities available in the United States and to present case studies that describe the potential energy generation from these types of hydropower projects. Those analyses have been included in a new DOE report to Congress, and this ORNL/TM provides additional technical details supporting that report. Conduit hydropower offers important new ways to enhance renewable energy portfolios in the United States, as well as to increase the energy efficiency of water delivery systems. Conduit hydropower projects are constructed on existing water-conveyance structures, such as irrigation canals or pressurized pipelines that deliver water to municipalities, industry, or agricultural water users. Although water conveyance infrastructures are usually designed for non-power purposes, new renewable energy can often be harvested from them without affecting their original purpose and without the need to construct new dams or diversions. Conduit hydropower differs from more conventional hydropower development in that it is generally not located on natural rivers or waterways and therefore does not involve the types of environmental impacts that are associated with hydropower. The addition of hydropower to existing water conduits can provide valuable new revenue sources from clean, renewable energy. The new energy can be used within the existing water distribution systems to offset other energy demands, or it can be sold into regional transmission systems.

  4. Neural-differentiated mesenchymal stem cells incorporated into muscle stuffed vein scaffold forms a stable living nerve conduit.

    Science.gov (United States)

    Hassan, Nur Hidayah; Sulong, Ahmad Fadzli; Ng, Min-Hwei; Htwe, Ohnmar; Idrus, Ruszymah B H; Roohi, Sharifah; Naicker, Amaramalar S; Abdullah, Shalimar

    2012-10-01

    Autologous nerve grafts to bridge nerve gaps have donor site morbidity and possible neuroma formation resulting in development of various methods of bridging nerve gaps without using autologous nerve grafts. We have fabricated an acellular muscle stuffed vein seeded with differentiated mesenchymal stem cells (MSCs) as a substitute for nerve autografts. Human vein and muscle were both decellularized by liquid nitrogen immersion with subsequent hydrolysis in hydrochloric acid. Human MSCs were subjected to a series of treatments with a reducing agent, retinoic acid, and a combination of trophic factors. The differentiated MSCs were seeded on the surface of acellular muscle tissue and then stuffed into the vein. Our study showed that 35-75% of the cells expressed neural markers such as S100b, glial fibrillary acidic protein (GFAP), p75 NGF receptor, and Nestin after differentiation. Histological and ultra structural analyses of muscle stuffed veins showed attachment of cells onto the surface of the acellular muscle and penetration of the cells into the hydrolyzed fraction of muscle fibers. We implanted these muscle stuffed veins into athymic mice and at 8 weeks post-implantation, the acellular muscle tissue had fully degraded and replaced with new matrix produced by the seeded cells. The vein was still intact and no inflammatory reactions were observed proving the biocompatibility and biodegradability of the conduit. In conclusion, we have successfully formed a stable living nerve conduit which may serve as a substitute for autologous nerves. Copyright © 2012 Orthopaedic Research Society.

  5. Hydraulic tomography of discrete networks of conduits and fractures in a karstic aquifer by using a deterministic inversion algorithm

    Science.gov (United States)

    Fischer, P.; Jardani, A.; Lecoq, N.

    2018-02-01

    In this paper, we present a novel inverse modeling method called Discrete Network Deterministic Inversion (DNDI) for mapping the geometry and property of the discrete network of conduits and fractures in the karstified aquifers. The DNDI algorithm is based on a coupled discrete-continuum concept to simulate numerically water flows in a model and a deterministic optimization algorithm to invert a set of observed piezometric data recorded during multiple pumping tests. In this method, the model is partioned in subspaces piloted by a set of parameters (matrix transmissivity, and geometry and equivalent transmissivity of the conduits) that are considered as unknown. In this way, the deterministic optimization process can iteratively correct the geometry of the network and the values of the properties, until it converges to a global network geometry in a solution model able to reproduce the set of data. An uncertainty analysis of this result can be performed from the maps of posterior uncertainties on the network geometry or on the property values. This method has been successfully tested for three different theoretical and simplified study cases with hydraulic responses data generated from hypothetical karstic models with an increasing complexity of the network geometry, and of the matrix heterogeneity.

  6. Functional collagen conduits combined with human mesenchymal stem cells promote regeneration after sciatic nerve transection in dogs.

    Science.gov (United States)

    Cui, Yi; Yao, Yao; Zhao, Yannan; Xiao, Zhifeng; Cao, Zongfu; Han, Sufang; Li, Xing; Huan, Yong; Pan, Juli; Dai, Jianwu

    2018-05-01

    Numerous studies have focused on the development of novel and innovative approaches for the treatment of peripheral nerve injury using artificial nerve guide conduits. In this study, we attempted to bridge 3.5-cm defects of the sciatic nerve with a longitudinally oriented collagen conduit (LOCC) loaded with human umbilical cord mesenchymal stem cells (hUC-MSCs). The LOCC contains a bundle of longitudinally aligned collagenous fibres enclosed in a hollow collagen tube. Our previous studies showed that an LOCC combined with neurotrophic factors enhances peripheral nerve regeneration. However, it remained unknown whether an LOCC seeded with hUC-MSCs could also promote regeneration. In this study, using various histological and electrophysiological analyses, we found that an LOCC provides mechanical support to newly growing nerves and functions as a structural scaffold for cells, thereby stimulating sciatic nerve regeneration. The LOCC and hUC-MSCs synergistically promoted regeneration and improved the functional recovery in a dog model of sciatic nerve injury. Therefore, the combined use of an LOCC and hUC-MSCs might have therapeutic potential for the treatment of peripheral nerve injury. Copyright © 2018 John Wiley & Sons, Ltd.

  7. Scaffoldless tissue-engineered nerve conduit promotes peripheral nerve regeneration and functional recovery after tibial nerve injury in rats

    Institute of Scientific and Technical Information of China (English)

    Aaron M. Adams; Keith W. VanDusen; Tatiana Y. Kostrominova; Jacob P. Mertens; Lisa M. Larkin

    2017-01-01

    Damage to peripheral nerve tissue may cause loss of function in both the nerve and the targeted muscles it innervates. This study compared the repair capability of engineered nerve conduit (ENC), engineered fibroblast conduit (EFC), and autograft in a 10-mm tibial nerve gap. ENCs were fabricated utilizing primary fibroblasts and the nerve cells of rats on embryonic day 15 (E15). EFCs were fabricated utilizing primary fi-broblasts only. Following a 12-week recovery, nerve repair was assessed by measuring contractile properties in the medial gastrocnemius muscle, distal motor nerve conduction velocity in the lateral gastrocnemius, and histology of muscle and nerve. The autografts, ENCs and EFCs reestablished 96%, 87% and 84% of native distal motor nerve conduction velocity in the lateral gastrocnemius, 100%, 44% and 44% of native specific force of medical gastrocnemius, and 63%, 61% and 67% of native medial gastrocnemius mass, re-spectively. Histology of the repaired nerve revealed large axons in the autograft, larger but fewer axons in the ENC repair, and many smaller axons in the EFC repair. Muscle histology revealed similar muscle fiber cross-sectional areas among autograft, ENC and EFC repairs. In conclusion, both ENCs and EFCs promot-ed nerve regeneration in a 10-mm tibial nerve gap repair, suggesting that the E15 rat nerve cells may not be necessary for nerve regeneration, and EFC alone can suffice for peripheral nerve injury repair.

  8. Laparoscopic ischemic conditioning of the stomach increases neovascularization of the gastric conduit in patients undergoing esophagectomy for cancer.

    Science.gov (United States)

    Pham, Thai H; Melton, Shelby D; McLaren, Patrick J; Mokdad, Ali A; Huerta, Sergio; Wang, David H; Perry, Kyle A; Hardaker, Hope L; Dolan, James P

    2017-09-01

    Gastric ischemic preconditioning has been proposed to improve blood flow and reduce the incidence of anastomotic complications following esophagectomy with gastric pull-up. This study aimed to evaluate the effect of prolonged ischemic preconditioning on the degree of neovascularization in the distal gastric conduit at the time of esophagectomy. A retrospective review of a prospectively maintained database identified 30 patients who underwent esophagectomy. The patients were divided into three groups: control (no preconditioning, n = 9), partial (short gastric vessel ligation only, n = 8), and complete ischemic preconditioning (left and short gastric vessel ligation, n = 13). Microvessel counts were assessed, using immunohistologic analysis to determine the degree of neovascularization at the distal gastric margin. The groups did not differ in age, gender, BMI, pathologic stage, or cancer subtype. Ischemic preconditioning durations were 163 ± 156 days for partial ischemic preconditioning, compared to 95 ± 50 days for complete ischemic preconditioning (P = 0.2). Immunohistologic analysis demonstrated an increase in microvessel counts of 29% following partial ischemic preconditioning (P = 0.3) and 67% after complete ischemic preconditioning (P gastric conduit. © 2017 Wiley Periodicals, Inc.

  9. Histological study of right ventricle-pulmonary artery valved conduit implantation (RPVC) in dogs with pulmonic stenosis.

    Science.gov (United States)

    Saida, Yuuto; Tanaka, Ryou; Fukushima, Ryuji; Hira, Satoshi; Hoshi, Katsuichiro; Soda, Aiko; Iizuka, Tomoya; Ishikawa, Taisuke; Nishimura, Taiki; Yamane, Yoshihisa

    2009-04-01

    We examined whether right ventricle-pulmonary artery valved conduit (RPVC) implantation can overcome the disadvantages of current procedures for pulmonic stenosis (PS). We histologically evaluated the feasibility of RPVC using a homograft in PS model dogs. Eight dogs underwent pulmonary artery banding (PAB) and then 12 weeks later were assigned to PAB (n=4) or PAB+RPVC (n=4) groups. Dogs in the PAB group received no treatment throughout the experimental period, whereas the PAB+RPVC group underwent RPVC. At 1 year after PAB, hearts and conduits were explanted from euthanized dogs and histologically evaluated. The ratios (%) of myocardial fibrosis on right ventricle (RV) epicardial, median and endocardial layers were significantly lower in the PAB+RPVC, than in the PAB group. The ratio of myocardial fibrosis on left ventricular (LV) epicardial and endocardial layers were significantly lower in the PAB+RPVC, than in the PAB group. Neo-intimal thickness in the anastomosis areas of the Denacol and PAB+RPVC groups was 42.77 +/- 30.19 and 88.30 +/- 27.24 microm, respectively, with no significant differences between the groups. Calcification and neo- intima hypertrophy were not obvious in the valve area. Immunohistological staining showed that the internal surface of the anastomosis and intermediate areas were positive for endothelial cells. We concluded that RPVC using a bioprosthetic graft can apparently overcome the disadvantages of current procedures for pulmonic stenosis.

  10. Controls on magma permeability in the volcanic conduit during the climactic phase of the Kos Plateau Tuff eruption (Aegean Arc)

    Science.gov (United States)

    Degruyter, W.; Bachmann, O.; Burgisser, A.

    2010-01-01

    X-ray computed microtomography (µCT) was applied to pumices from the largest Quaternary explosive eruption of the active South Aegean Arc (the Kos Plateau Tuff; KPT) in order to better understand magma permeability within volcanic conduits. Two different types of pumices (one with highly elongated bubbles, tube pumice; and the other with near spherical bubbles, frothy pumice) produced synchronously and with identical chemical composition were selected for µCT imaging to obtain porosity, tortuosity, bubble size and throat size distributions. Tortuosity drops on average from 2.2 in frothy pumice to 1.5 in tube pumice. Bubble size and throat size distributions provide estimates for mean bubble size (~93-98 μm) and mean throat size (~23-29 μm). Using a modified Kozeny-Carman equation, variations in porosity, tortuosity, and throat size observed in KPT pumices explain the spread found in laboratory measurements of the Darcian permeability. Measured difference in inertial permeability between tube and frothy pumices can also be partly explained by the same variables but require an additional parameter related to the internal roughness of the porous medium (friction factor f 0 ). Constitutive equations for both types of permeability allow the quantification of laminar and turbulent gas escape during ascent of rhyolitic magma in volcanic conduits.

  11. Impact of Age and Aerobic Exercise Training on Conduit Artery Wall Thickness: Role of the Shear Pattern.

    Science.gov (United States)

    Tanahashi, Koichiro; Kosaki, Keisei; Sawano, Yuriko; Yoshikawa, Toru; Tagawa, Kaname; Kumagai, Hiroshi; Akazawa, Nobuhiko; Maeda, Seiji

    2017-01-01

    Hemodynamic shear stress is the frictional force of blood on the arterial wall. The shear pattern in the conduit artery affects the endothelium and may participate in the development and progression of atherosclerosis. We investigated the role of the shear pattern in age- and aerobic exercise-induced changes in conduit artery wall thickness via cross-sectional and interventional studies. In a cross-sectional study, we found that brachial shear rate patterns and brachial artery intima-media thickness (IMT) correlated with age. Additionally, brachial artery shear rate patterns were associated with brachial artery IMT in 102 middle-aged and older individuals. In an interventional study, 39 middle-aged and older subjects were divided into 2 groups: control and exercise. The exercise group completed 12 weeks of aerobic exercise training. Aerobic exercise training significantly increased the antegrade shear rate and decreased the retrograde shear rate and brachial artery IMT. Moreover, changes in the brachial artery antegrade shear rate and the retrograde shear rate correlated with the change in brachial artery IMT. The results of the present study indicate that changes in brachial artery shear rate patterns may contribute to age- and aerobic exercise training-induced changes in brachial artery wall thickness. © 2017 S. Karger AG, Basel.

  12. Perinatal development influences mechanisms of bradykinin-induced relaxations in pulmonary resistance and conduit arteries differently.

    Science.gov (United States)

    Boels, P J; Deutsch, J; Gao, B; Haworth, S G

    2001-07-01

    As bradykinin (BYK) relaxes conduit (EPA) and resistance (RPA) pulmonary arteries from both perinatal and adult lungs, we investigated whether this vasodilator's relaxation-mechanisms were altered during perinatal development, differed between EPA and RPA and differed with other endothelium-dependent vasodilators, acetyicholine (ACH) and substance P (SP). Arteries from mature foetal (5 days), neonatal (approximately 5 min), newborn (60-84 h) and adult pigs (> or =6 months) were isolated, mounted for in vitro isometric force recording, activated with PGF(2alpha) (30 micromol/l) and relaxed with BYK (10 pmol/l-1 micromol/l), SP (10 pmol/l-0.1 micromol/l) or ACH (1 nmol/l-1 mmol/l). (i) BYK: L-NAME (100 micromol/l) attenuated relaxations in foetal EPA ( approximately 55%) but nearly abolished them in the adult ( approximately 80%). In RPA, L-NAME nearly abolished ( approximately 90%) relaxations in the foetus and this effect diminished progressively with age to approximately 20% in the adult. Indomethacin (IND, micromol/l) attenuated relaxations in neonatal (approximately 25%), new-born and adult EPA (both approximately 45%). Together, L-NAME and IND abolished relaxations in all EPA and in neonatal RPA but not in older RPA. SKF525a (100 micromol/l) attenuated relaxations in foetal RPA ( approximately 4%), diminishing in the adult RPA to approximately 10%. Together, SKF52Sa and L-NAME largely abolished relaxations in postnatal RPA (approximately 80%). Activation with K(+)=125 mmol/l attenuated relaxations in adult EPA (approximately 80%), foetal RPA ( approximately 45%) and neonatal RPA (approximately 75%) and abolished relaxations in RPA from older ages. (ii) ACH: L-NAME abolished relaxations in new-born EPA and RPA. In adult EPA, combined L-NAME and IND moderately attenuated relaxations. (iii) SP: Combined application of L-NAME and IND attenuated relaxations to a similar degree in new-born and adult EPA and RPA. In postnatal EPA, BYK-relaxations depend completely on

  13. New catalysts for photocatalytic cleaning of waste water; Neue Katalysatoren zur photokatalytischen Abwasserreinigung

    Energy Technology Data Exchange (ETDEWEB)

    Lindner, M [Inst. for Solarenergieforschung GmbH, Hannover (Germany); Bahnemann, D [Inst. for Solarenergieforschung GmbH, Hannover (Germany); Hirthe, B [Sachtleben Chemie, Duisburg (Germany); Griebler, W D [Sachtleben Chemie, Duisburg (Germany)

    1994-11-01

    Cleaning of polluted ground and waste water meets with particular problems where the group of halogenated hydrocarbons is concerned, which are not, or not readily, to be biologically degraded by conventional techniques. As an alternative technique to waste water cleaning, a method known as photocatalysis was proposed some years ago, which removes the organic pollutants by oxidation at semiconductor particles exposed to a light source. The article reports on a newly developed photocatalyst with distinctly enhanced pollutant degradation efficiency. (orig./EF) [Deutsch] Besondere Schwierigkeiten bei der Reinigung verschmutzter Grund- und Abwaesser bereitet die Gruppe der halogenierten Kohlenwasserstoffe, die sich nicht oder nur schwer auf herkoemmliche Weise biologisch abbauen lassen. Als alternative Technik zur Abwasserreinigung wurde vor einigen Jahren die sogenannte Photokatalyse vorgeschlagen, bei der die organischen Schadstoffe durch Oxidation an belichteten Halbleiterteilchen entfernt werden. Nachfolgend wird ueber einen neu entwickelten Photokatalysator berichtet, mit dessen Hilfe eine deutliche Steigerung der Effektivitaet des photokatalytischen Schadstoffabbaus gelingt. (orig./EF)

  14. Total balance of biogenic fuels for thermal uses; Ganzheitliche Bilanzierung verschiedener biogener Festbrennstoffe zur thermischen Nutzung

    Energy Technology Data Exchange (ETDEWEB)

    Becher, S.; Kaltschmitt, M. [Stuttgart Univ. (Germany). Inst. fuer Energiewirtschaft und Rationelle Energieanwendung (IER)

    1996-12-31

    In this situation of unfavourable energy price levels, the use of biogenic fuels for power supply can be recommended only if it serves to reduce environmental pollution. Against this background and on the basis of a primary energy balance, the authors attempted a total balance of selected enfironmental effects (global heating and acidification potential) of biomass use as compared to fossil fuel combustion. (orig) [Deutsch] ie Nutzung biogener Festbrennstoffe zur Energienachfragedeckung ist bei dem gegenwaertigen unguenstigen Energiepreisniveau nur dann zu rechtfertigen, wenn es durch die Biomassenutzung zu einer Reduzierung der energiebedingten Umwelteffekte kommt. Vor disem Hintergrund werden ausgehend von der Primaerenergiebilanz ausgewaehlte Umwelteffekte (d.h. das Treibhaus- und das Versauerungspotential) einer Biomassenutzung im Vergleich zu einer Nutzung fossiler Energietraeger ganzheitlich bilanziert. Die wesentlichen Ergebnisse werden zusammengefasst und interpretiert. (orig)

  15. Investigations of pollutant migration using lysimeters; Untersuchungen zur Schadstoff-Migration in Lysimetern

    Energy Technology Data Exchange (ETDEWEB)

    Klotz, D. (ed.)

    2002-07-01

    The third GSF Lysimeter Workshop focused on pollutant migration in underground strata, i.e. the dispersion of water constituents as referred to water transport on the basis of ideal tracer investigations. [German] Der am 29./30.04.2002 stattgefundene Workshop 'Untersuchungen zur Schadstoffmigration in Lysimetern' war der dritte GSF-Lysimeterworkshop nach denen in den Jahren 1998 und 2000 veranstalteten. Nachdem in den Jahren 1998 und 2000 der Wassertransport und die Bestimmung der Sickerwassergeschwindigkeit in Lysimetern im Mittelpunkt standen, war 2002 die Schadstoffmigration im Untergrund der Schwerpunkt der Vortraege und Poster. Unter Migration wird das Ausbreitungsverhalten von Wasserinhalts-(Fremd-, Schad-)Stoffen bezogen auf den Wassertransport, bestimmt mit idealen Tracern, verstanden. (orig.)

  16. Total balance of biogenic fuels for thermal uses; Ganzheitliche Bilanzierung verschiedener biogener Festbrennstoffe zur thermischen Nutzung

    Energy Technology Data Exchange (ETDEWEB)

    Becher, S; Kaltschmitt, M [Stuttgart Univ. (Germany). Inst. fuer Energiewirtschaft und Rationelle Energieanwendung (IER)

    1997-12-31

    In this situation of unfavourable energy price levels, the use of biogenic fuels for power supply can be recommended only if it serves to reduce environmental pollution. Against this background and on the basis of a primary energy balance, the authors attempted a total balance of selected enfironmental effects (global heating and acidification potential) of biomass use as compared to fossil fuel combustion. (orig) [Deutsch] ie Nutzung biogener Festbrennstoffe zur Energienachfragedeckung ist bei dem gegenwaertigen unguenstigen Energiepreisniveau nur dann zu rechtfertigen, wenn es durch die Biomassenutzung zu einer Reduzierung der energiebedingten Umwelteffekte kommt. Vor disem Hintergrund werden ausgehend von der Primaerenergiebilanz ausgewaehlte Umwelteffekte (d.h. das Treibhaus- und das Versauerungspotential) einer Biomassenutzung im Vergleich zu einer Nutzung fossiler Energietraeger ganzheitlich bilanziert. Die wesentlichen Ergebnisse werden zusammengefasst und interpretiert. (orig)

  17. Zur Rekonstruktion einer Typologie jugendlichen Medienhandelns gemäß dem Leitbild der Triangulation

    Directory of Open Access Journals (Sweden)

    Klaus Peter Treumann

    2017-09-01

    Full Text Available Die im Folgenden dargestellten Ergebnisse sind im Rahmen des von der DFG geförderten Forschungsprojekts „Eine Untersuchung zum Mediennutzungsverhalten 12- bis 20-Jähriger und zur Entwicklung von Medienkompetenz im Jugendalter“ entstanden, das gemeinsam von Klaus Peter Treumann, Uwe Sander und Dorothee Meister geleitet wird. Das Forschungsprojekt untersucht das Medienhandeln Jugendlicher sowohl hinsichtlich Neuer als auch alter Medien. Zum einen fragen wir dabei nach den Ausprägungen von Medienkompetenz in verschiedenen Dimensionen und zum anderen konzentrieren wir uns auf die Entwicklung einer empirisch fundierten Typologie jugendlichen Medienhandelns. Methodologisch ist die Untersuchung an dem Leitbild der Triangulation orientiert und kombiniert qualitative und quantitative Zugänge zum Forschungsfeld in Form von Gruppendiskussionen, leitfadengestützten Einzelinterviews und einer Repräsentativerhebung.

  18. Simulator to evaluate and optimise driver assistance systems; Ein Simulator zur Bewertung und Optimierung von Fahrerassistenzsystemen

    Energy Technology Data Exchange (ETDEWEB)

    Locher, J. [Hella KG Hueck and Co., Paderborn (Germany); Kleinkes, M. [Hella KG Hueck and Co., Lippstadt (Germany)

    2003-07-01

    For a short time now, the L-LAB (Light-LABoratory), a joint research facility of Hella KG and the University of Paderborn, has had a simulator available which allows the evaluation of driver assistance systems and the optimisation of man-machine interfaces. It is an interactive night driver simulator, which can be used to visualise any type of headlamp beam pattern true to the original. A Smart is used as the input medium; image projection is via a 3-channel high-performance beamer projection system onto large screens. Alongside synthetic roads, there is also a digitalised course available, approx. 10 km long, the original of which is actually used by Hella as a proving ground. Road safety indicators can be recorded directly and indirectly. For example, obstacles which suddenly appear force drivers to apply the brakes. The stopping distance required can be interpreted as a direct indicator for safety. In addition, an eye tracking system is used to record the eye movements of the test subjects, which allows additional road safety indicators to be derived. Comparative investigations between the digitalised proving ground and reality allow validation of the simulator. This year, a comprehensive study will be made to optimise the man-machine interface in connection with infrared vision systems in vehicles. The advantages of simulation are not only in the economical implementation possibilities and control of the variables, but also the fact that properties of driver assistance systems can be evaluated which are not even technically possible yet in reality. The use of the simulator developed here is not limited to tests connected with the visibility of obstacles, however. Rather, it allows the investigation and evaluation of a large range of potential driver assistance systems. (orig.) [German] Dem L-LAB (Light-LABoratory), einer gemeinsamen Forschungseinrichtung der Universitaet Paderborn und der Firma Hella KG in Lippstadt, steht seit kurzer Zeit ein Simulator zur

  19. Konsensus zur Anwendung der "Tension-free Vaginal Tape" (TVT Operation bei der weiblichen Belastungsinkontinenz

    Directory of Open Access Journals (Sweden)

    Hanzal E

    2003-01-01

    Full Text Available Unter der Patronanz der Medizinischen Gesellschaft für Inkontinenzhilfe Österreich wurde im Juni 2002 in Wien die 2. Auflage eines Österreichischen Tension-free Vaginal Tape (TVT Konsensus-Meetings abgehalten. TVT ist eine neue Operationstechnik zur Behandlung der weiblichen Stressharninkontinenz, die seit 1998 in Österreich eingesetzt wird. Im Rahmen des Treffens, an dem Experten aus den Fachbereichen Urologie und Gynäkologie teilnahmen, wurde die vorhandene Fachliteratur analysiert und ein Konsensus für die präoperative Abklärung, Durchführung und postoperative Verlaufskontrolle als Basis für eine laufende Qualitätsverbesserung des Verfahrens erarbeitet, dessen Ergebnis in dem vorliegenden Papier als Leitlinie zusammengefaßt ist.

  20. ENZIAN-Klassifikation zur Diskussion gestellt: Eine neue differenzierte Klassifikation der tief infiltrierenden Endometriose

    Directory of Open Access Journals (Sweden)

    Tuttlies F

    2008-01-01

    Full Text Available Mit Einführung des ENZIAN-Scores wurde eine neue Klassifikation für die Erkrankung der Endometriose vorgestellt, die insbesondere die tief infiltrierende Endometriose mit der typischen retroperitonealen Manifestation berücksichtigt. In Anlehnung an onkologische Stadieneinteilungen wurde eine Einteilung in vier Schweregrade gewählt, die mit drei Raumachsen zur Lokalisation der Erkrankung erweitert wurden. Der ENZIAN-Score versteht sich als eine Ergänzung zu dem bekannten rAFS-System (revised American Fertility and Sterility Score, das sich lediglich auf die intraperitoneale Manifestation der Endometriose anwenden lässt. In vielen Fällen ist die rAFS-Klassifikation nur bedingt oder gar nicht geeignet, die Ausdehnung und den Schweregrad der Erkrankung darzustellen. Am Kollektiv von Patientinnen mit Darmendometriose wurde der ENZIAN- Score retrospektiv auf die klinische Wertigkeit hin untersucht und bewährte sich in der klinischen Anwendung.

  1. Die „Leipziger schule”. Zur geschichte der kirchenmusik Im 20. jahrhundert

    Directory of Open Access Journals (Sweden)

    Loos Helmut

    2013-01-01

    Full Text Available Auf die Initiative Karls Straubes ging die Gründung des Instituts für Kirchenmusik am Leipziger Konservatorium im Jahre 1921 zurück. Zusammen mit seinem Meisterschüler Günther Ramin gestaltete er über lange Jahre hinweg die Kirchenmusik in St. Thomas. Nach dem Ende des Ersten Weltkriegs gewann die Bach-Bewegung für den Protestantismus eine zentrale Bedeutung, zumal sich Leipzig als richtungsweisendes Zentrum profilierte und mit der „Ära Straube-Ramin” eine „Leipziger Schule” ausbildete. Obwohl Straube und Ramin nicht selbst komponierten, war insbesondere ihr Wirken am Konservatorium der Musik zu Leipzig wesentlich für die Bildung der „Leipziger Schule” als Erneuerungsbewegung evangelischer Kirchenmusik. In dem Artikel wird das Schicksal dieser Bestrebungen und ihrer Protagonisten während der katastrophalen ökonomischen Umstände und des anwachsenden Nationalisozialismus analysiert.

  2. Invasive procedure for clarification of pulmonary nodules; Invasive Verfahren zur Abklaerung pulmonaler Rundherde

    Energy Technology Data Exchange (ETDEWEB)

    Mahnken, A.H. [Universitaetsklinikum, Philipps-Universitaet Marburg, Klinik fuer Diagnostische und Interventionelle Radiologie, Marburg (Germany)

    2014-05-15

    The management of solitary lung nodules poses a common clinical problem and biopsy is often required. Several guidelines provide slightly different recommendations and there are no uniform recommendations regarding the ideal technique of puncture guidance (e.g. percutaneous versus bronchoscopic or thoracoscopic). Fine needle aspiration biopsy (FNA) and core biopsy are well established techniques. Both can be performed under CT and to some extent ultrasound guidance. Diagnostic accuracies of FNA and core biopsy for malignant lesions are around 95 %. Core biopsy is superior to FNA for establishing a specific diagnosis with a diagnostic yield of 81-88 % versus 17-21 %. In clinical routine practice core biopsy is the superior tool when compared to FNA. Central lesions in close proximity to bronchi may be biopsied with endobronchial ultrasound (EBUS)-guided bronchoscopy. In all other lesions percutaneous, ideally CT-guided biopsy should be the method of first choice. (orig.) [German] Solitaere Lungenrundherde stellen ein haeufiges differenzialdiagnostisches Problem dar, das oftmals mit der Bildgebung alleine nicht endgueltig zu loesen ist und eine Biopsie erfordert. Die Indikation zur Biopsie variiert zwischen den Leitlinien, und die beste Technik der Biopsie (perkutan vs. bronchoskopisch vs. thorakoskopisch) ist oftmals nicht eindeutig. Feinnadelaspirations- (FNA) und Stanzbiopsie stehen als lange etablierte Standardtechniken zur Verfuegung. Beide koennen CT- und bedingt ultraschallgesteuert durchgefuehrt werden. Die diagnostische Aussagekraft fuer die Diagnose maligner Tumoren liegt fuer beide Techniken bei 95 %. Die Stanzbiopsie ist jedoch der FNA fuer die spezifische Diagnose benigner Prozesse mit einer Genauigkeit von 82-88 vs. 17-21 % ueberlegen. Die Stanzbiopsie ist gegenueber der FNA das in der klinischen Routine ueberlegene Werkzeug. Bei sehr zentralen Herden in Nachbarschaft zu einem Bronchus kann primaer eine bronchoskopische EBUS-gesteuerte (endobronchialer

  3. Vorschrift oder Thunfisch? – Zur Langzeitverfügbarkeit von Forschungsdaten

    Directory of Open Access Journals (Sweden)

    Tim Hasler

    2013-10-01

    Full Text Available Ich mache ihm ein Angebot, das er nicht ablehnen kann.” Diese Aussage aus einem gänzlich anderen Kontext lässt sich recht treffend übertragen als Wunsch von Dienstleistern und Zweck von Dienstleistungen für Datenproduzenten im Forschungsdatenmanagement. Zwar wirkt Druck zur Datenübergabe nicht förderlich, die Eröffnung einer Option aber sehr wohl. Im vorliegenden Artikel geht es um das Verständnis der Nachhaltigkeit von Forschung und ihren Daten anhand der Erkenntnisse und Erfahrungen aus der ersten Phase des DFG-Projekts EWIG. [Fn 01] Eine Auswahl von Fallstricken beim Forschungsdatenmanagement wird anhand der Erkenntnisse aus Expertengesprächen und eigenen Erfahrungen beim Aufbau von LZA-Workflows vorgestellt. Erste Konzepte in EWIG zur Datenübertragung aus unterschiedlich strukturierten Datenquellen in die „Langfristige Domäne” werden beschrieben. "I'm gonna make him an offer he can't refuse". This quote from a completely different context can be aptly rendered as a statement of service providers as well as the purpose of services for data producers in the field of research data management. Although pressure is not the leverage of choice if you want researchers to deposit their research data in some kind of repository, offering an option does the trick quite well. In this article we present some of the concepts for sustainability of research and its data from the first phase the of the project EWIG, funded by the Deutsche Forschungsgemeinschaft. A selection of pitfalls in research data management is presented based on the findings from expert interviews and our own experiences in the construction of LTP workflows. First concepts in EWIG to transfer data from differently structured data sources into the "Permanent Domain" are described.

  4. Lehrerkooperation: theoretische reflexion über voraussetzungen zur erweiterung von kooperativität bei lehrern

    Directory of Open Access Journals (Sweden)

    Rainer Lengert

    2012-01-01

    Full Text Available Viele Bildungseinrichtungen verfolgen den Ausbau der Zusammenarbeit zwischen Lehrern, mit der Absicht, das Arbeitsklima zu pflegen und vor allem zur Verbesserung der Qualität ihres Bildungsangebotes. Allerdings bereiten die kooperativen Initiativen oft Unannehmlichkeiten, es sei denn, die Beteiligten kennen die umfangreichen Hintergründe, die höhere oder mindere Ebenen von Kooperation erleichtern oder behindern können. Diese Lücke wird im vorliegenden Artikel abgehandelt, indem neun Prämissen als Voraussetzung zur Erweiterung der Kooperation zwischen Lehrern dargestellt werden. Im Bewusstsein dieser Prämissen, ist es möglich, empirische Erforschungen künftig zu instrumentalisieren, wie auch Wege zu schaffen, Anforderungen an Lehrer und Schulen gewisser zu verwalten.Abstract Muitas instituições escolares têm aderido à busca de ampliar a cooperação entre seus professores, com a intenção de cuidar do ambiente de trabalho, mas, principalmente, de melhorar a qualidade de ensino oferecida. Porém, as iniciativas cooperativas costumam enfrentar dificuldades, sem que os envolvidos tenham conhecimento das causas amplas que impedem ou facilitam maiores ou menores níveis de cooperação. É dessa lacuna que trata o presente artigo, discutindo nove premissas que subjazem à possibilidade de ampliar a cooperação entre professores. Tendo consciência das premissas, é possível instrumentalizar futuras pesquisas empíricas, como também criar meios de gerir os requisitos que são de responsabilidade dos professores e das instituições escolares.

  5. Ein kombinierter Operationsansatz zur Therapie der rektovaginalen Endometriose auf der Basis histologischer Befunde

    Directory of Open Access Journals (Sweden)

    Köhler C

    2008-01-01

    Full Text Available Einleitung: Eine Endometriose des Septum rectovaginale kann oberflächlich dem Darm aufliegen oder die Darmwand infiltrieren. Durch bildgebende Verfahren kann jedoch präoperativ eine Infiltration des Darms weder hinreichend bestätigt noch ausgeschlossen werden, was zu einem therapeutischen Dilemma führt, da nur die Darmwand eindeutig infiltrierende Endometrioseprozesse durch eine Darmresektion behandelt werden sollten. Wir möchten ein neues Operationsverfahren vorstellen, das eine intraoperative Differenzierung zwischen einer oberflächlichen und einer infiltrativen Darmendometriose erlaubt. Patienten und Methodik: 70 Patientinnen mit rektovaginaler Endometriose wurden nach einem neu entwickelten kombinierten vaginal-laparoskopisch-abdominalen Verfahren operiert. Diese Operationsmethode wird Schritt für Schritt vorgestellt. Die Entscheidung zur Darmresektion wurde dabei allein aufgrund der intraoperativen Befunde und nicht aufgrund der präoperativen bildgebenden Diagnostik getroffen. Alle Resektate wurden standardisiert histologisch aufgearbeitet. Ergebnisse: Ob eine Darmresektion notwendig war, ließ sich intraoperativ anhand der Präparation des rektovaginalen Septums entscheiden. Daher wurden nur bei Patientinnen mit gesichertem infiltrativem Darmbefall Darmresektionen unter Erhalt des Mesointestinums durchgeführt. Weder intraoperative noch postoperative Komplikationen wie Anastomoseninsuffizienzen oder Restharnmengen traten auf. Diskussion: Die vorgestellte Operationsmethode zur Therapie der rektovaginalen Endometriose erlaubt eine exakte Diagnosestellung und präzise Therapieentscheidung bei minimaler Morbidität. Die Resektion des Darmschlauches ohne Mesoresektion ist ausreichend, da sich die Endometrioseknoten – wie histologisch bewiesen wurde – nur im ventralen Darmbereich befinden. Durch die Mesoerhaltung werden die vegetativen Funktionen des kleinen Beckens nicht beeinträchtigt.

  6. Functional and regenerative effects of local administration of autologous mononuclear bone marrow cells combined with silicone conduit on transected femoral nerve of rabbits.

    Science.gov (United States)

    Trindade, Anelise Bonilla; Schestatsky, Pedro; Torres, Vítor Félix; Gomes, Cristiano; Gianotti, Giordano Cabral; Paz, Ana Helena da Rosa; Terraciano, Paula Barros; Marques, Janete Maria Volpato; Guimarães, Karina Magano; Graça, Dominguita Lühers; Cirne-Lima, Elizabeth Obino; Contesini, Emerson Antonio

    2015-10-01

    The inoculation of cells into injury sites can accelerate and improve the quality of nerve regeneration. This study aimed to evaluate the functional and regenerative effects of mononuclear autologous bone marrow cells (MABMC) combined with silicon conduit grafting in rabbit femoral nerves. Twenty-eight animals were allocated to one of two groups: treatment group (TG) or control group (CG), divided according to the time of evaluation, at either 50 or 75 days. After neurotmesis of the femoral nerve, surgical repair was performed with nerve autografts in silicon conduits, leaving a 5mm gap in both groups. The TG received MABMC in silicon conduits, and CG received a sham saline inoculum. Histological, clinical and electrophysiological analyses detected no differences between groups, but analysis of leg diameter showed that TG diameters were larger. This cell therapy did not improve regeneration of the femoral nerve, but there was a tendency for better functional recovery. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. Biodegradable chitin conduit tubulation combined with bone marrow mesenchymal stem cell transplantation for treatment of spinal cord injury by reducing glial scar and cavity formation

    Directory of Open Access Journals (Sweden)

    Feng Xue

    2015-01-01

    Full Text Available We examined the restorative effect of modified biodegradable chitin conduits in combination with bone marrow mesenchymal stem cell transplantation after right spinal cord hemisection injury. Immunohistochemical staining revealed that biological conduit sleeve bridging reduced glial scar formation and spinal muscular atrophy after spinal cord hemisection. Bone marrow mesenchymal stem cells survived and proliferated after transplantation in vivo, and differentiated into cells double-positive for S100 (Schwann cell marker and glial fibrillary acidic protein (glial cell marker at 8 weeks. Retrograde tracing showed that more nerve fibers had grown through the injured spinal cord at 14 weeks after combination therapy than either treatment alone. Our findings indicate that a biological conduit combined with bone marrow mesenchymal stem cell transplantation effectively prevented scar formation and provided a favorable local microenvironment for the proliferation, migration and differentiation of bone marrow mesenchymal stem cells in the spinal cord, thus promoting restoration following spinal cord hemisection injury.

  8. Biodegradable chitin conduit tubulation combined with bone marrow mesenchymal stem cell transplantation for treatment of spinal cord injury by reducing glial scar and cavity formation

    Science.gov (United States)

    Xue, Feng; Wu, Er-jun; Zhang, Pei-xun; Li-ya, A; Kou, Yu-hui; Yin, Xiao-feng; Han, Na

    2015-01-01

    We examined the restorative effect of modified biodegradable chitin conduits in combination with bone marrow mesenchymal stem cell transplantation after right spinal cord hemisection injury. Immunohistochemical staining revealed that biological conduit sleeve bridging reduced glial scar formation and spinal muscular atrophy after spinal cord hemisection. Bone marrow mesenchymal stem cells survived and proliferated after transplantation in vivo, and differentiated into cells double-positive for S100 (Schwann cell marker) and glial fibrillary acidic protein (glial cell marker) at 8 weeks. Retrograde tracing showed that more nerve fibers had grown through the injured spinal cord at 14 weeks after combination therapy than either treatment alone. Our findings indicate that a biological conduit combined with bone marrow mesenchymal stem cell transplantation effectively prevented scar formation and provided a favorable local microenvironment for the proliferation, migration and differentiation of bone marrow mesenchymal stem cells in the spinal cord, thus promoting restoration following spinal cord hemisection injury. PMID:25788929

  9. Construction of nerve guide conduits from cellulose/soy protein composite membranes combined with Schwann cells and pyrroloquinoline quinone for the repair of peripheral nerve defect.

    Science.gov (United States)

    Luo, Lihua; Gan, Li; Liu, Yongming; Tian, Weiqun; Tong, Zan; Wang, Xiong; Huselstein, Celine; Chen, Yun

    2015-02-20

    Regeneration and functional reconstruction of peripheral nerve defects remained a significant clinical challenge. Nerve guide conduits, with seed cells or neurotrophic factors (NTFs), had been widely used to improve the repair and regeneration of injured peripheral nerve. Pyrroloquinoline quinone (PQQ) was an antioxidant that can stimulate nerve growth factors (NGFs) synthesis and accelerate the Schwann cells (SCs) proliferation and growth. In present study, three kinds of nerve guide conduits were constructed: one from cellulose/SPI hollow tube (CSC), another from CSC combined with SCs (CSSC), and the third one from CSSC combined with PQQ (CSSPC), respectively. And then they were applied to bridge and repair the sciatic nerve defect in rats, using autograft as control. Effects of different nerve guide conduits on the nerve regeneration were comparatively evaluated by general analysis, sciatic function index (SFI) and histological analysis (HE and TEM). Newly-formed regenerative nerve fibers were observed and running through the transparent nerve guide conduits 12 weeks after surgery. SFI results indicated that the reconstruction of motor function in CSSPC group was better than that in CSSC and CSC groups. HE images from the cross-sections and longitudinal-sections of the harvested regenerative nerve indicated that regenerative nerve fibers had been formed and accompanied with new blood vessels and matrix materials in the conduits. TEM images also showed that lots of fresh myelinated and non-myelinated nerve fibers had been formed. Parts of vacuolar, swollen and abnormal axons occurred in CSC and CSSC groups, while the vacuolization and swell of axons was the least serious in CSSPC group. These results indicated that CSSPC group had the most ability to repair and reconstruct the nerve structure and functions due to the comprehensive contributions from hollow CSC tube, SCs and PQQ. As a result, the CSSPC may have the potential for the applications as nerve guide

  10. Plan de empresa para la creación de un restaurante de comida casual argentina Punta Zur

    OpenAIRE

    Arango B., Gustavo Adolfo; Isaacs, Laura

    2011-01-01

    RESUMEN: Punta Zur, será un restaurante de comida casual dentro de la categoría de comida rápida, ubicado en Granada, Cali, que iniciará operaciones en Mayo de 2012. Los productos ofrecidos serán platos típicos del sur del continente americano, entre ellos el choripán y las brochetas (res, cerdo y pollo). También se ofrecerán acompañantes tales como papas, yucas fritas, chips de plátano y bebidas como jugos naturales, gaseosas y cervezas. En Punta Zur los clientes encontrarán un sitio en el q...

  11. Conduit dynamics in transitional rhyolitic activity recorded by tuffisite vein textures from the 2008-2009 Chaitén eruption

    Directory of Open Access Journals (Sweden)

    Elodie eSaubin

    2016-05-01

    Full Text Available The mechanisms of hazardous silicic eruptions are controlled by complex, poorly-understood conduit processes. Observations of recent Chilean rhyolite eruptions have revealed the importance of hybrid activity, involving simultaneous explosive and effusive emissions from a common vent. Such behaviour hinges upon the ability of gas to decouple from magma in the shallow conduit. Tuffisite veins are increasingly suspected to be a key facilitator of outgassing, as they repeatedly provide a transient permeable escape route for volcanic gases. Intersection of foam domains by tuffisite veins appears critical to efficient outgassing. However, knowledge is currently lacking into textural heterogeneities within shallow conduits, their relationship with tuffisite vein propagation, and the implications for fragmentation and degassing processes. Similarly, the magmatic vesiculation response to upper conduit pressure perturbations, such as those related to the slip of dense magma plugs, remains largely undefined. Here we provide a detailed characterization of an exceptionally large tuffisite vein within a rhyolitic obsidian bomb ejected during transitional explosive-effusive activity at Chaitén, Chile in May 2008. Vein textures and chemistry provide a time-integrated record of the invasion of a dense upper conduit plug by deeper fragmented magma. Quantitative textural analysis reveals diverse vesiculation histories of various juvenile clast types.Using vesicle size distributions, bubble number densities, zones of diffusive water depletion, and glass H2O concentrations, we propose a multi-step degassing/fragmentation history, spanning deep degassing to explosive bomb ejection. Rapid decompression events of ~3-4 MPa are associated with fragmentation of foam and dense magma at ~200-350 metres depth in the conduit, permitting vertical gas and pyroclast mobility over hundreds of metres. Permeable pathway occlusion in the dense conduit plug by pyroclast accumulation

  12. Simulation of Microdamage and Evaluation of Remaining Life of Steam Conduit Components from New-Generation Refractory Steel 10Kh9MF-Sh

    Science.gov (United States)

    Gladshtein, V. I.

    2018-03-01

    The effects of microdamage on the remaining life of high-temperature components of steam conduits from high-chromium steel 10Kh9MF-Sh and low-alloy steel 12Kh1M1F are compared. To simulate the microdamage, specimens with a circular notch and different relative diameters are fabricated. Specimens with a notch simulating the highest degree of microdamage and smooth specimens are tested for long-term strength. The coefficient of the remaining life of a conduit is computed for the range of relative damage presenting practical interest.

  13. Untersuchungen zur Involution der Vagina and Zervix beim Rind post partum unter Berücksichtigung der Zervix als Geburtshindernis

    OpenAIRE

    Wehrend, Axel

    2002-01-01

    Ziel der vorliegenden Arbeit war es die physiologische Involution der Zervix im Vergleich zur Vagina beim Rind während der ersten zehn Tage post partum zu charakterisieren. Weiterhin sollte durch klinische Untersuchungen an Kühen nach Dystokie und einer retrospektiven Datenauswertung von Schwergeburten unterschiedlicher Tierarten der Anteil zervikal bedingter Geburtsstockungen im Interspeziesvergleich analysiert und Einflussfaktoren auf das Auftreten dieser Dystokieform sowie Störungen in der...

  14. Neue numerische Methoden zur Bearbeitung und 3D-Interpretation von Geodaten und -modellen in interdisziplinärer Forschung

    OpenAIRE

    Menzel, Peter

    2016-01-01

    In dieser Arbeit wird gezeigt, wie Ansätze und Verfahren aus der Geoinformatik die Prozessierung und Interpretation von Daten in der Geophysik, speziell der Potentialverfahren unterstützen. Im Rahmen des BMBF-Verbundprojekts AIDA wurde für ein Untersuchungsgebiet in Norddeutschland ein 3D Untergrundmodell entwickelt. Hier wird gezeigt, wie die Modellgeometrie für die Schweremodellierung aufbereitet wurde. Anschließend wird ein hier entwickeltes Verfahren zur statistischen Abschätzung un...

  15. Zur Ätiologie und Bekämpfung der Lumpy Jaw Disease bei Kängurus

    OpenAIRE

    Asperger, Michael

    2004-01-01

    In der vorliegenden Arbeit sollten die in der veterinärmedizinischen Literatur bisher diskutierten Ursachen für LJD bei Makropoden hinsichtlich ihrer tatsächlichen Bedeutung abgeklärt und die Eignung einer formalininaktivierten, bestandsspezifischen Adsorbatvakzine zur Prophylaxe von LJD getestet werden. Da LJD eine parodontale Erkrankung darstellt, wurden auch die für Entstehung einer humanen Parodontitis prädisponierenden Faktoren mit in die Untersuchung einbezogen. Es wurden Tupferproben z...

  16. Furane, Furanone und Pyranone – ihr Beitrag zur Farbe und den antioxidativen Eigenschaften in der Maillard-Reaktion der Maltose

    OpenAIRE

    Kanzler, Clemens

    2017-01-01

    Die Maillard-Reaktion ist dafür bekannt, bei der thermischen Behandlung von Lebensmitteln neben deren organoleptischen Eigenschaften, wie Geschmack, Geruch, Textur und Farbe, auch die oxidative Stabilität zu beeinflussen. Letzteres ist auf die Bildung von komplexierenden und reduzierenden Verbindungen zurückzuführen, die antioxidativ und prooxidativ wirken können. Im Rahmen der vorliegenden Arbeit werden die antioxidativen Kapazitäten von dreizehn Maillard-Reaktionsintermediaten mit Furan-...

  17. Practical guide to more efficient use of energy in industry; Praxisleitfaden zur Foerderung der rationellen Energieverwendung in der Industrie

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-09-04

    Starting with an easily digestible explanation of fundamental concepts and terms in the field of energy and its applications, as well as the related thermodynamic principles and processes, the second chapter explains the system of energy and exergy. Chapters 3 and 4 give a comprehensive picture of current technologies and processes in energy generation and engineering, from energy applications for process heat generation through to power plants and combined and heat and power systems, fuel cells and energy generation from renewable primary sources, discussing related aspects of interest such as energy and pollutant emissions, and economic aspects. Chapter 5 is devoted to counselling and guidance for corporate energy engineering analysis and enhancement. Chapters 6 and 7 round up the comprehensive information addressing the legal aspects of procedures for licensing of energy generation and conversion systems, and the various financing instruments and schemes available for projects intended to promote more efficient use of energy. (orig./CB) [Deutsch] Ausgehend von einer anschaulichen Beschreibung grundlegender Energiebegriffe und thermodynamischer Zusammenhaenge wird im zweiten Kapitel in klarer Weise das Zusammenspiel zwischen Energie und Exergie dargestellt. Aufbauend auf diesen grundlegenden Hinweisen bieten die Kapitel 3 und 4 eine weitreichende Uebersicht der gegenwaertig zur Verfuegung stehenden Prozess- und Energietechniken. Ausgehend von Techniken zur Prozesswaermebereitstellung spannt sich der Bogen ueber Kraftanlagen und Kraft-Waerme-Kopplungssysteme bis hin zu Brennstoffzellen und regenerativen Energietechniken, wobei der Schwerpunkt der Betrachtungen auf Energie- und Emissionsaspekte sowie wirtschaftliche Randbedingungen gelegt wurde. Kapitel 5 gibt Hinweise zur Vorbereitung und Durchfuehrung energietechnischer Beratungen und Analysen auf betrieblicher Ebene. Im Anschluss an den technischen Teil dieses Leitfadens folgt in Kapitel 6 eine Erlaeuterung der

  18. Freilanduntersuchungen zur Ökologie und zum Verhalten von Trachypithecus auratus kohlbruggei (Haubenlanguren) im West-Bali-Nationalpark, Indonesien

    OpenAIRE

    Vogt, Martina

    2003-01-01

    Languren gehören zu den asiatischen Schlankaffen, die zusammen mit den afrikanischen Stummelaffen die Unterfamilie Colobinae, neben den Cercopithecinae die zweite rezente Gruppe der Cercopithecoidea, bilden. Während heute über viele Vertreter der Cercopithecinae zahlreiche Langzeitstudien zu verschiedenen Jahreszeiten und in unterschiedlichen Habitaten vorliegen, ist über die Biologie der Colobinae noch vergleichsweise wenig bekannt. Die Kenntnisse zur Lebensweise vieler Schlank- und Stummela...

  19. Zur Aktualität der identitären Ideologie : die Vordenker einer neuen rechten Internationale

    OpenAIRE

    Brumlik, Micha

    2017-01-01

    Rechtspopulistische Bewegungen machen sich zur Zeit in vielen westlichen Staaten zum Sprachrohr angeblich bisher unterdrückter Bevölkerungsgruppen und Meinungen. Die identitäre Bewegung entwickelt diesen Ansatz weiter zu einem Projekt der autoritären Staatlichkeit gegen Multikulturalismus, Islam und Einwanderung. Dabei verbindet sie ihre Kampagne für einen ethnisch geschlossen Nationalstaat mit der Kritik an der kapitalistischen Globalisierung. Mit einem Sprachduktus, der Politik emotionalisi...

  20. Paediatric Virology as a new educational initiative: An interview with Nobelist Professor of Virology Harald zur Hausen.

    Science.gov (United States)

    Mammas, Ioannis N; Spandidos, Demetrios A

    2017-10-01

    Born in Gelsenkirchen-Buer in Germany on March 11th, 1936, Professor Harald zur Hausen, Emeritus Professor of Virology at the University of Freiburg and 2008 Nobel Prize Laureate in Physiology or Medicine for his discovery of human papillomavirus (HPV), which causes cervical cancer, believes that good knowledge of virological methods and diagnostic possibilities are an asset for all young paediatricians. Professor zur Hausen considers that the creation of an educational platform on Paediatric Virology is definitely very beneficial for young paediatricians, as this will greatly enhance their knowledge in the field of Virology. He very actively advocates the vaccination of boys for the eradication of HPV infection and emphasises that male HPV vaccination should be included into the current vaccination programmes. He would have certainly considered Dr George N. Papanicolaou (Kyme, Island of Euboea, Greece, 1883 - Miami, Florida, USA, 1962) as an excellent candidate for the Nobel Prize, stating that the contribution of Dr Papanicolaou did not find sufficient recognition in the past. In the context of the 3rd Workshop on Paediatric Virology, which will be held in Athens, Greece, on October 7th, 2017, Professor zur Hausen will give his plenary lecture on 'Paediatric Virology and Oncology: Virus persistence and the important first years of life'.

  1. The potentials of spiral CT for detection of focal liver lesions; Moeglichkeiten der Spiral-CT zur Diagnostik fokaler Leberlaesionen

    Energy Technology Data Exchange (ETDEWEB)

    Helmberger, H. [Technische Univ. Muenchen, Klinikum rechts der Iser, Inst. fuer Roentgendiagnostik (Germany); Kersting-Sommerhoff, B. [Technische Univ. Muenchen, Klinikum rechts der Iser, Inst. fuer Roentgendiagnostik (Germany); Lenz, M. [Technische Univ. Muenchen, Klinikum rechts der Iser, Inst. fuer Roentgendiagnostik (Germany); Kirsten, R. [Technische Univ. Muenchen, Klinikum rechts der Iser, Inst. fuer Roentgendiagnostik (Germany); Bautz, W. [Technische Univ. Muenchen, Klinikum rechts der Iser, Inst. fuer Roentgendiagnostik (Germany)

    1996-03-01

    Spiral CT currently is the modality of choice for all aspects of diagnostic evaluation of the liver. Optimal selection of treatment should be based inter alia on the findings obtained by spiral CT with arterial application of contrast medium, as for example S-CTA (primary liver tumors), or S-CTAP (secondary liver tumors). Ultrasonography is the major supplementing modality. In the near future, MR imaging applying liver-specific contrast-enhancing agents is expected to become an important competing technique, and further developments of interest in diagnostic imaging of the liver are in the offing: it is not yet known which technique will be the modality of choice at the onset of the 21st century. (orig.) [Deutsch] Die Spiral-CT ist zur Zeit das empfehlenswerte Verfahren fuer alle Fragen der Leberdiagnostik. Zur optimalen praetherapeutischen Beurteilung der Leber sollte die Spiral-CT mit arterieller Kontrastmittelapplikation als S-CTA (primaere Lebertumoren) bzw. S-CTAP (sekundaere Lebertumoren) durchgefuehrt werden. Der US kommt ein Stellenwert als ergaenzende Methode zu. In Zukunft wird die MRT mit leberspezifischen Kontrastmitteln ein konkurrierendes Verfahren zur Spiral-CT darstellen, wobei eine weitere interessante Entwicklung auf dem Gebiet der hepatischen Bildgebung zu erwarten ist: Das diagnostische Verfahren der Wahl fuer die Leber zu Beginn des 21. Jahrhunderts ist noch nicht definiert. (orig.)

  2. An algorithm for calculating unsteady flow with free surface; Ein Verfahren zur Berechnung instationaerer Stroemungen mit freier Oberflaeche

    Energy Technology Data Exchange (ETDEWEB)

    Janetzky, B.

    2001-07-01

    A numerical model for the transient, free surface flow is implemented in a Finite-Element program for the unsteady calculation of incompressible flow with free surface. The program is used to calculate the flow in different components of a hydraulic turbine, the Pelton turbine. The movement of the fluid with free surface is described mathematically by introducing a partial differential equation for the volume fraction. This equation is simply a transport equation for f, i.e. the volume fraction is advected with the flow in time. The equations is solved numerically. (orig.) [German] Es wird ein Verfahren zur Modellierung von veraenderlichen, freien Oberflaechen vorgestellt und in einem Finite-Elemente-Programm zur numerischen Berechnung von instationaeren, inkompressiblen Stroemungen implementiert. Die veraenderliche, freie Oberflaeche wird mit einem Volume-Of-Fluid Ansatz erfasst. Zur Approximierung der freien Oberflaeche werden stueckweise konstante oder gestufte Verlaeufe im Element angesetzt. Es werden die Eigenschaften des Verfahrens an ausgewaehlten Beispielen mit freier Oberflaeche untersucht. Das erweiterte Programm wird auf instationaere Stroemungen mit freier Oberflaeche in einer hydraulischen Maschine, der Peltonturbine, angewandt. (orig.)

  3. Study on the dynamic behavior of a current in cable-in-conduit conductors by using self magnetic field measurements

    Energy Technology Data Exchange (ETDEWEB)

    Obana, Tetsuhiro, E-mail: obana.tetsuhiro@LHD.nifs.ac.jp [National Institute for Fusion Science, 322-6 Oroshi, Toki 509-5292, Gifu (Japan); Takahata, Kazuya; Hamaguchi, Shinji; Imagawa, Shinsaku; Mito, Toshiyuki [National Institute for Fusion Science, 322-6 Oroshi, Toki 509-5292, Gifu (Japan); Kizu, Kaname; Murakami, Haruyuki; Yoshida, Kiyoshi [Japan Atomic Energy Agency, Ibaraki (Japan)

    2011-10-15

    In order to understand the current behavior inside a cable-in-conduit conductor (CICC), self magnetic field measurements on the CICC were conducted. A prototype NbTi CICC, the configuration of which is a racket shape, for JT-60SA EF coil was used as a short conductor sample. By using Hall sensors arranged around the short conductor sample, the variation in the self magnetic field was measured. Taking into account the measurements, the current behavior inside the CICC was analyzed by using analytical models consisting of line currents. The analytical results indicate that the current distribution in the cross-section of the CICC would be non-uniform before a normal propagation, and the current distribution would be improved after the normal propagation.

  4. Helium flow dynamics and heat transfer in a cable in conduit conductor of superconducting magnets: a review

    International Nuclear Information System (INIS)

    Vaghela, Hitensinh; Sarkar, Biswanath; Lakhera, Vikas

    2016-01-01

    Superconducting (SC) magnets with Cable in Conduit Conductor (CICC) winding, cooled by helium at 4 K temperature are employed for many applications which require high magnetic field and high current densities. The construction of CICC aims to maintain superconductivity state by optimization of various parameters, i.e., thermal stability, ratio of normal conductor to superconductor material, mechanical strength, low hydraulic impedance, current density, magnetic field, etc. The cryogenic thermal stability of the CICC is of prime importance for the safe, stable and reliable operation of SC magnets. The prediction of thermal and hydraulic behaviour of CICC in large SC magnets is difficult due to the complex geometry, variation of fluid properties, various heat in-flux incidences over the long length of CICC and a complex heat transport phenomenon. A systematic review of the thermal and hydraulic studies of CICC has been presented in the paper highlighting the challenges and opportunities for further improvement in its design and performance. (author)

  5. Three-dimensional fluid mechanics of particulate two-phase flows in U-bend and helical conduits

    Science.gov (United States)

    Tiwari, Prashant; Antal, Steven P.; Podowski, Michael Z.

    2006-04-01

    The results of numerous studies performed to date have shown that the performance of various hydraulic systems can be significantly improved by using curved conduit geometries instead of straight tubes. In particular, the formation of Dean vortices, which enhance the development of centrifugal instabilities, has been identified as a factor behind reducing the near-wall concentration buildup in particulate flow devices (e.g., in membrane filtration modules). Still, several issues regarding the effect of conduit curvature on local multidimensional phenomena governing fluid flow still remain open. A related issue is concerned with the impact that conduit geometry makes on the concentration distribution of a dispersed phase in two-phase flows in general, and in particulate flows (solid/liquid or solid/gas suspensions) in particular. It turns out that only very limited efforts have been made in the past to understand the fluid mechanics of such flows via advanced computer simulations. The purpose of this paper is to present the results of full three-dimensional (3D) theoretical and numerical analyses of single- and two-phase dilute particle/liquid flows in U-bend and helical curved conduits. The numerical analysis is based on computational fluid dynamics (CFD) simulations performed using a state-of-the-art multiphase flow computer code, NPHASE. The major issues discussed in the first part of the paper are concerned with the effect of curved/coiled geometry on the evolution of flow field and the associated wall shear. It has been demonstrated that the primary curvature (a common factor for both the U-bend and helix geometries) may cause a substantial asymmetry in the radial distribution of the main flow velocity. This, in turn, leads to a significant, albeit highly nonuniform, increase in the wall shear stress. Specifically, the wall shear around the outer half of tube circumference may become twice the corresponding value for a straight tube, and gradually decrease to

  6. Electromagnetic analysis of a superconducting transformer for high current characterization of cable in conduit conductors in background magnetic field

    Science.gov (United States)

    Wu, Xiangyang; Tan, Yunfei; Fang, Zhen; Jiang, Donghui; Chen, Zhiyou; Chen, Wenge; Kuang, Guangli

    2017-10-01

    A large cable-in-conduit-conductor (CICC) test facility has been designed and fabricated at the High Magnetic Field Laboratory of the Chinese Academy of Sciences (CHMFL) in order to meet the test requirement of the conductors which are applied to the future fusion reactor. The critical component of the test facility is an 80 kA superconducting transformer which consists of a multi-turn primary coil and a minor-turn secondary coil. As the current source of the conductor samples, the electromagnetic performance of the superconducting transformer determines the stability and safety of the test facility. In this paper, the key factors and parameters, which have much impact on the performance of the transformer, are analyzed in detail. The conceptual design and optimizing principles of the transformer are discussed. An Electromagnetic-Circuit coupled model built in ANSYS Multiphysics is successfully used to investigate the electromagnetic characterization of the transformer under the dynamic operation condition.

  7. Status reports on the development and application of acoustic emission analysis. Proceedings; Statusberichte zur Entwicklung und Anwendung der Schallemissionsanalyse. Beitraege

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    This proceedings-CD comprises 20 papers presented at the 17. Kolloquium Schallemission (Acoustic Emission Colloquium) at Bad Schandau. The following subjects were discussed: 1. Acoustic emission analysis of tensile tests on standard test specimens of different wood materials; 2. Application of pattern recognition methods for damage analyses of fibre-reinforced plastics; 3. Acoustic emission analysis for measuring crack growth in finned armor steel under dynamic load; 4. Acoustic emission analysis with zonal sound location: Test objects, test results and evaluation of acoustic emission signals; 5. Acoustic emission analysis in overall fatigue testing of a wind rotor blade; 6. Laboratory methods for assessing the sensitivity of acoustic emission sensors; 7. Acoustic emission analysis in burst tests of cast aluminium casings; 8. Visualization of acoustic emission localizations; 9. Threshold-independent and complete recording of characteristics and wave forms of transient and continuous acoustic emission; 10. Characterization of wide-band acoustic emission sensors; 11. Handling of large data volumes in acoustic emission analysis, a contribution to the development of algorithms; 12. Acoustic emission analysis and ultrasonic analysis for the characterization of crack networks in saline rock. One of the papers is available as a separate record in this database. [German] Diese Tagungs-CD enthaelt 20 Vortraege, die auf dem 17. Kolloquium Schallemission in Bad Schandau gehalten wurden. Die Themen waren: 1. Schallemissionsanalyse von Zugversuchen an Standardpruefkoerpern aus unterschiedlichen Holzwerkstoffen; 2. Anwendung von Mustererkennungsverfahren zur Schadensanalyse in faserverstaerkten Kunststoffen; 3. Anwendung der Schallemissionsanalyse zur Ermittlung des Risswachstums bei schwingender Beanspruchung von geripptem Bewehrungsstahl; 4. Schallemissionspruefung mit zonaler Ortung Pruefobjekte, Pruefergebnisse und Nachbewertung von Schallemissionssignalen; 5

  8. Design and synthesis of elastin-like polypeptides for an ideal nerve conduit in peripheral nerve regeneration

    Energy Technology Data Exchange (ETDEWEB)

    Hsueh, Yu-Sheng [Institute of Biomedical Engineering, College of Engineering, National Taiwan University, Taipei 100, Taiwan (China); Institute of Biomedical Engineering, College of Medicine, National Taiwan University, Taipei 100, Taiwan (China); Savitha, S. [Institute of Biomedical Engineering, College of Engineering, National Taiwan University, Taipei 100, Taiwan (China); Department of Biotechnology, Sree Sastha Institute of Engineering and Technology, Chennai (India); Institute of Biomedical Engineering, College of Medicine, National Taiwan University, Taipei 100, Taiwan (China); Sadhasivam, S. [Division of Biomedical Engineering and Nanomedicine Research, National Health Research Institutes, Miaoli 350, Taiwan (China); Lin, Feng-Huei, E-mail: double@ntu.edu.tw [Institute of Biomedical Engineering, College of Engineering, National Taiwan University, Taipei 100, Taiwan (China); Division of Biomedical Engineering and Nanomedicine Research, National Health Research Institutes, Miaoli 350, Taiwan (China); Institute of Biomedical Engineering, College of Medicine, National Taiwan University, Taipei 100, Taiwan (China); Shieh, Ming-Jium [Institute of Biomedical Engineering, College of Engineering, National Taiwan University, Taipei 100, Taiwan (China); College of Medicine, National Taiwan University Hospital, Taipei 100, Taiwan (China); Institute of Biomedical Engineering, College of Medicine, National Taiwan University, Taipei 100, Taiwan (China)

    2014-05-01

    The study involves design and synthesis of three different elastin like polypeptide (ELP) gene monomers namely ELP1, ELP2 and ELP3 that encode for ELP proteins. The formed ELPs were assessed as an ideal nerve conduit for peripheral nerve regeneration. ELP1 was constructed with a small elongated pentapeptide carrying VPGVG sequence to mimic the natural polypeptide ELP. The ELP2 was designed by the incorporation of 4-penta peptide chains to improve the biocompatibility and mechanical strength. Thus, the third position in unique VPGVG was replaced with alanine to VPAVG and in a similar way modified to VPGKG, VPGEG and VPGIG with the substitution of lysine, glutamic acid and isoleucine. In ELP3, fibronectin C5 domain endowed with REDV sequence was introduced to improve the cell attachment. The ELP1, ELP2 and ELP3 proteins expressed by Escherichia coli were purified by inverse transition cycling (ITC). The purified ELPs were confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and western blotting. The Schwann cell (SC) morphology and cell adhesion were assessed by fabrication of ELP membrane cross-linked with glutaraledhyde. The Schwann cell proliferation was measured by WST-1 assay. Immunofluorostaining of Schwann cells was accomplished with SC specific phenotypic marker, S100. - Highlights: • Design and synthesis of three gene monomers of elastin like polypeptides (ELP1, 2 and 3) were reported. • Molecular weight of ITC purified ELP1, ELP2 and ELP3 was in the range of 37–38 kDa. • Schwann cell adhesion was found to be prominent in ELP3 and could be used as nerve conduit for peripheral nerve regeneration.

  9. An international multicenter study comparing arrhythmia prevalence between the intracardiac lateral tunnel and the extracardiac conduit type of Fontan operations.

    Science.gov (United States)

    Balaji, Seshadri; Daga, Ankana; Bradley, David J; Etheridge, Susan P; Law, Ian H; Batra, Anjan S; Sanatani, Shubayan; Singh, Anoop K; Gajewski, Kelly K; Tsao, Sabrina; Singh, Harinder R; Tisma-Dupanovic, Svjetlana; Tateno, Shigeru; Takamuro, Motoki; Nakajima, Hiromichi; Roos-Hesselink, Jolien W; Shah, Maully

    2014-08-01

    The study objective was to determine whether the extracardiac conduit Fontan confers an arrhythmia advantage over the intracardiac lateral tunnel Fontan. This multicenter study of 1271 patients compared bradyarrhythmia (defined as need for pacing) and tachyarrhythmia (defined as needing antiarrhythmic therapy) between 602 patients undergoing the intracardiac Fontan and 669 patients undergoing the extracardiac Fontan. The median age at the time of the Fontan procedure was 2.1 years (interquartile range, 1.6-3.2 years) for the intracardiac group and 3.0 years (interquartile range, 2.4-3.9) for the extracardiac group (P 30 days) bradyarrhythmia occurred in 105 patients (18%) in the intracardiac group and 63 patients (9%) in the extracardiac group (P 30 days) tachyarrhythmia occurred in 58 patients (10%) in the intracardiac group and 23 patients (3%) in the extracardiac group (P factoring time since surgery, more patients in the extracardiac group had early bradycardia (odds ratio, 2.9; 95% confidence interval, 1.8-4.6), with no difference in early tachycardia, late bradycardia, or late tachycardia. Overall arrhythmia burden is similar between the 2 groups, but the extracardiac Fontan group had a higher incidence of early bradyarrhythmias. There was no difference in the incidence of late tachyarrhythmias over time between the 2 operations. Therefore, the type of Fontan performed should be based on factors other than an anticipated reduction in arrhythmia burden from the extracardiac conduit. Copyright © 2014 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.

  10. Design and synthesis of elastin-like polypeptides for an ideal nerve conduit in peripheral nerve regeneration

    International Nuclear Information System (INIS)

    Hsueh, Yu-Sheng; Savitha, S.; Sadhasivam, S.; Lin, Feng-Huei; Shieh, Ming-Jium

    2014-01-01

    The study involves design and synthesis of three different elastin like polypeptide (ELP) gene monomers namely ELP1, ELP2 and ELP3 that encode for ELP proteins. The formed ELPs were assessed as an ideal nerve conduit for peripheral nerve regeneration. ELP1 was constructed with a small elongated pentapeptide carrying VPGVG sequence to mimic the natural polypeptide ELP. The ELP2 was designed by the incorporation of 4-penta peptide chains to improve the biocompatibility and mechanical strength. Thus, the third position in unique VPGVG was replaced with alanine to VPAVG and in a similar way modified to VPGKG, VPGEG and VPGIG with the substitution of lysine, glutamic acid and isoleucine. In ELP3, fibronectin C5 domain endowed with REDV sequence was introduced to improve the cell attachment. The ELP1, ELP2 and ELP3 proteins expressed by Escherichia coli were purified by inverse transition cycling (ITC). The purified ELPs were confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and western blotting. The Schwann cell (SC) morphology and cell adhesion were assessed by fabrication of ELP membrane cross-linked with glutaraledhyde. The Schwann cell proliferation was measured by WST-1 assay. Immunofluorostaining of Schwann cells was accomplished with SC specific phenotypic marker, S100. - Highlights: • Design and synthesis of three gene monomers of elastin like polypeptides (ELP1, 2 and 3) were reported. • Molecular weight of ITC purified ELP1, ELP2 and ELP3 was in the range of 37–38 kDa. • Schwann cell adhesion was found to be prominent in ELP3 and could be used as nerve conduit for peripheral nerve regeneration

  11. [Laparoscopic cystectomy and ileal conduit urinary diversion for neurogenic bladders and related conditions. Morbidity and better quality of life].

    Science.gov (United States)

    Sakhri, R; Seigle-Murandi, F; Jacqmin, D; Lang, H; Saussine, C

    2015-05-01

    To assess morbidity and functional consequences of laparoscopic cystectomy with ileal conduit urinary diversion: in neurologic patients. We reviewed the records of forty-two patients (ten men and thirty-two women) who underwent surgery between August 2007 and October 2013. The median age of the patient was 54 years old (range between 21-79 years). A laparoscopic cystectomy was performed followed by a short laparotomy to perform the ileal conduit urinary diversion. Records were reviewed to retrieve the indications and describe the postoperative and functional course. Patients and GPs were interviewed during phone calls to appreciate the quality of life by the PGII scale in order to assess the functional outcome. The operation was performed on 42 patients, of whom 18 had multiple sclerosis, nine a post-traumatic neurogenic bladder. Among the total population, 10 patients (23.81%) required a transfusion of at least one packed red blood cells (1-7). The overall rate of early complications was 35.71%. Belated complications were seen in 52.38% of the population. The median duration of hospital stay was 16 days (range between 9-70 days). The median follow up was 34 months (range between 1-76 months). For patients, the PGII scale rating had a median value of 6 (2-7). All referring physicians described a better functional status. The laparoscopic cystectomy can make postoperative course smoother for the neurological patients. However, the surgeon must weigh individually the benefit of performing the operation. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  12. Ecoulements intermittents de gaz et de liquide en conduite verticale Intermittent Gas and Liquid Flows in a Vertical Pipe.

    Directory of Open Access Journals (Sweden)

    Line A.

    2006-11-01

    Full Text Available Le modèle présenté ici permet la pré-détermination du gradient de pression, du taux global de gaz, et de grandeurs caractéristiques de l'intermittence, dans un écoulement à poches et bouchons en conduite verticale. L'écriture des lois de conservation en moyenne phasique conditionnelle conduit à la définition d'une cellule moyenne équivalente. La fermeture du modèle est assurée par des lois de contrainte de cisaillement film-paroi, film-poche, bouchon-paroi, par une loi d'arrachage du gaz au culot de la poche, une loi de glissement du gaz dans les bouchons et par une loi de la vitesse moyenne de propagation des fronts de poches. Le calibrage et la qualification du modèle s'appuient sur deux banques de données, dont l'une a été obtenue avec des fluides pétroliers dans des conditions proches des situations industrielles (boucle diphasique de Boussens. The model described here can be used to predetermine the pressure gradient, the overall gas rate and the characteristic intermittence magnitudes in pocket and slug flow in a vertical pipe. The way governing equations in the conditional phase average are written defines an equivalent average cell. The model is closed by film/wall, film/pocket and slug/wall shear-stress laws, by a pulloff law for the gas at the bottom of the pocket, a slippage law for the gas in the slugs, and a mean propagation velocity law for the pocket fronts. The calibration and qualification of the model are based on two data banks, one of which contains data on petroleum fluids under conditions close to industrial situations (two-phase loop at Boussens.

  13. Pulmonary artery reconstruction with a tailor-made bovine pericardial conduit following sleeve resection of a long segmental pulmonary artery for the treatment of lung cancer: technical details of the dog-ear method for adjusting diameter during vascular anastomosis.

    Science.gov (United States)

    Shimizu, Kimihiro; Nagashima, Toshiteru; Ohtaki, Yoichi; Takahashi, Toru; Mogi, Akira; Kuwano, Hiroyuki

    2017-05-01

    Sleeve resection of the pulmonary artery (PA) is always required for lung-sparing operations in which half or more of the vessel circumference is infiltrated by the primary tumor or metastatic hilar nodes. Following sleeve resection, conduit reconstruction may be indicated if there is excessive distance between the two vascular stumps, because there is a high degree of tension when repaired by direct anastomosis. We herein present a case of PA reconstruction using a tailor-made bovine pericardial conduit after sleeve resection of PA during lung cancer surgery. The length of resection was longer than 3 cm, and the difference in diameter between the conduit and peripheral PA stump was larger than 0.5 cm. We describe the surgical and oncological merits of a bovine pericardial conduit, and provide details of our reconstruction technique, focusing on adjustment of diameter between the conduit and peripheral PA (dog-ear method).

  14. Aerodynamic improvement of the assembly through which gas conduits are taken into a smoke stack by simulating gas flow on a computer

    Science.gov (United States)

    Prokhorov, V. B.; Fomenko, M. V.; Grigor'ev, I. V.

    2012-06-01

    Results from computer simulation of gas flow motion for gas conduits taken on one and two sides into the gas-removal shaft of a smoke stack with a constant cross section carried out using the SolidWorks and FlowVision application software packages are presented.

  15. Sprache als Schlüssel zur Welt: Bibliotheken und Sprach-Kitas in guter Partnerschaft

    Directory of Open Access Journals (Sweden)

    Susanne Brandt

    2017-12-01

    Full Text Available Von 2016 bis voraussichtlich 2020 wird durch das Bundesministerium für Familie, Senioren, Frauen und Jugend das Bundesprogramm „Sprach-Kitas. Weil Sprache der Schlüssel zur Welt ist“ gefördert. Es richtet sich an Kindertageseinrichtungen, die von einem überdurchschnittlich hohen Anteil von Kindern mit besonderem Bedarf an sprachlicher Bildung und Förderung besucht werden. Dabei stehen besonders die folgenden drei Zielbereiche im Fokus: alltagsintegrierte sprachliche Bildung, inklusive Bildung und Zusammenarbeit mit den Familien. An den Standorten dieser mehr als 3000 Sprach-Kitas in Deutschland gibt es nahezu überall öffentliche Bibliotheken, die als nachbarschaftliche Partnerinnen den Sprach-Kitas bei der Sprachförderung mit vielfältigen Medien und Kooperationsangeboten zur Seite stehen. Auch als Schnittstelle zwischen Kita und Familie können die Büchereien wichtige Aufgaben im Rahmen des Programms übernehmen. Die Büchereizentrale Schleswig-Holstein hat daher mit Fördermitteln des Landes und in guter Abstimmung mit den Sprachkoordinatorinnen der Kitas das Projekt „Mit Worten wachsen“ entwickelt. Der Beitrag beschreibt, welche Chancen und Herausforderungen sich durch eine solche Zusammenarbeit mit Sprach-Kitas für Bibliotheken ergeben und wie sich daraus eine lebendige interdisziplinäre Partnerschaft im Sinne der genannten Zielbereiche entwickeln lässt. Since 2016, the Federal Ministry for Family Affairs, Senior Citizens, Women and Youth has sponsored the programme “Language day-care centres. Because language is the key to the world” (Sprach-Kitas. Weil Sprache der Schlüssel zur Welt ist; this is expected to last until 2020. The programme addresses day-care facilities which are attended by an above-average number of children with special needs in their language development. The following three aims are at the centre of the programme: language education which is integrated in everyday life; education based on

  16. Numerical simulation of freshwater/seawater interaction in a dual-permeability karst system with conduits: the development of discrete-continuum VDFST-CFP model

    Science.gov (United States)

    Xu, Zexuan; Hu, Bill

    2016-04-01

    Dual-permeability karst aquifers of porous media and conduit networks with significant different hydrological characteristics are widely distributed in the world. Discrete-continuum numerical models, such as MODFLOW-CFP and CFPv2, have been verified as appropriate approaches to simulate groundwater flow and solute transport in numerical modeling of karst hydrogeology. On the other hand, seawater intrusion associated with fresh groundwater resources contamination has been observed and investigated in numbers of coastal aquifers, especially under conditions of sea level rise. Density-dependent numerical models including SEAWAT are able to quantitatively evaluate the seawater/freshwater interaction processes. A numerical model of variable-density flow and solute transport - conduit flow process (VDFST-CFP) is developed to provide a better description of seawater intrusion and submarine groundwater discharge in a coastal karst aquifer with conduits. The coupling discrete-continuum VDFST-CFP model applies Darcy-Weisbach equation to simulate non-laminar groundwater flow in the conduit system in which is conceptualized and discretized as pipes, while Darcy equation is still used in continuum porous media. Density-dependent groundwater flow and solute transport equations with appropriate density terms in both conduit and porous media systems are derived and numerically solved using standard finite difference method with an implicit iteration procedure. Synthetic horizontal and vertical benchmarks are created to validate the newly developed VDFST-CFP model by comparing with other numerical models such as variable density SEAWAT, couplings of constant density groundwater flow and solute transport MODFLOW/MT3DMS and discrete-continuum CFPv2/UMT3D models. VDFST-CFP model improves the simulation of density dependent seawater/freshwater mixing processes and exchanges between conduit and matrix. Continuum numerical models greatly overestimated the flow rate under turbulent flow

  17. Magnetic losses and reactance change by the use of metallic conduit in electrical installations; Perdidas magneticas y cambio de reactancia por la tuberia metalica en instalaciones electricas

    Energy Technology Data Exchange (ETDEWEB)

    Campero Littlewood, Eduardo; Castaneda D, Miguel; Castulo A, Roberto; Bratu Serban, Neagu [Universidad Autonoma Metropolitana-Azcapotzalco, Mexico, D. F. (Mexico)

    1996-12-31

    In this paper are presented the results obtained in the measurement of magnetic losses in metallic conduits in electric installations. The losses for parasitic currents and by hysteresis were obtained in different conditions of magnetic density, caused by the net current resulting from the sum of all the currents of all the conductors that travel along the conduit. These currents are named differential currents, and the conditions in which they appear in the electric installations are described. The magnetic induction phenomenon that occurs in metallic conduit is briefly described and the basic concepts that describe it. A theoretical-experimental methodology is offered to quantify the energy losses by parasitic currents and by the metal magnetization in these metallic conduits. At the same time, the impact of these differential currents impact in the reactance of the electric installation is quantified. The obtained results for twelve conduits of different diameters and different wall thickness are shown. A comparison analysis is made with the reported results in a previous article, where the losses were estimated by means of the temperature rise measurement of the metallic wall. [Espanol] En este articulo se presentan los resultados obtenidos en la medicion de perdidas magneticas en tuberias conduit (metalicas) en instalaciones electricas. Las perdidas por corrientes parasitas y por histeresis se obtuvieron para diferentes condiciones de densidad magnetica, provocada por la corriente neta resultante de la suma de las corrientes de todos los conductores que viajan por la tuberia. A estas corrientes se les designa corrientes diferenciales y se describen las condiciones en las que estas aparecen en las instalaciones electricas. Se explica brevemente el fenomeno de induccion magnetica que se presenta en las tuberias metalicas y los conceptos basicos que la describen. Se plantea una metodologia teorico-experiemental para cuantificar las perdidas de energia, por

  18. Magnetic losses and reactance change by the use of metallic conduit in electrical installations; Perdidas magneticas y cambio de reactancia por la tuberia metalica en instalaciones electricas

    Energy Technology Data Exchange (ETDEWEB)

    Campero Littlewood, Eduardo; Castaneda D, Miguel; Castulo A, Roberto; Bratu Serban, Neagu [Universidad Autonoma Metropolitana-Azcapotzalco, Mexico, D. F. (Mexico)

    1997-12-31

    In this paper are presented the results obtained in the measurement of magnetic losses in metallic conduits in electric installations. The losses for parasitic currents and by hysteresis were obtained in different conditions of magnetic density, caused by the net current resulting from the sum of all the currents of all the conductors that travel along the conduit. These currents are named differential currents, and the conditions in which they appear in the electric installations are described. The magnetic induction phenomenon that occurs in metallic conduit is briefly described and the basic concepts that describe it. A theoretical-experimental methodology is offered to quantify the energy losses by parasitic currents and by the metal magnetization in these metallic conduits. At the same time, the impact of these differential currents impact in the reactance of the electric installation is quantified. The obtained results for twelve conduits of different diameters and different wall thickness are shown. A comparison analysis is made with the reported results in a previous article, where the losses were estimated by means of the temperature rise measurement of the metallic wall. [Espanol] En este articulo se presentan los resultados obtenidos en la medicion de perdidas magneticas en tuberias conduit (metalicas) en instalaciones electricas. Las perdidas por corrientes parasitas y por histeresis se obtuvieron para diferentes condiciones de densidad magnetica, provocada por la corriente neta resultante de la suma de las corrientes de todos los conductores que viajan por la tuberia. A estas corrientes se les designa corrientes diferenciales y se describen las condiciones en las que estas aparecen en las instalaciones electricas. Se explica brevemente el fenomeno de induccion magnetica que se presenta en las tuberias metalicas y los conceptos basicos que la describen. Se plantea una metodologia teorico-experiemental para cuantificar las perdidas de energia, por

  19. Aussagen zur deutschen Sprache in den zwischen 2003 und 2013 erschienenen Werken der Chamisso-Preistragenden

    Directory of Open Access Journals (Sweden)

    Johannes Gröbl

    2017-04-01

    Full Text Available Da sich aus Aussagen von Chamisso-Literatur-Verfassenden über die deutsche Sprache interessante Schlüsse ziehen lassen, wird im Folgenden eine Sammlung von entsprechenden Zitaten aus Werken der Chamisso-Preistragenden aus den Jahren 2003 bis 2013 nach linguistischen Themen sortiert präsentiert. Die beispielhafte Dekade ist nicht völlig willkürlich gewählt, denn sie zeigt sich als ein Zeitraum, in dem viele der bisherigen Chamisso-Preistragenden tatsächlich Werke veröffentlichten. Sie bietet sich daher dafür an, exemplarisch zu zeigen, welche Aussagen über die deutsche Sprache aus Chamisso-Literatur gewonnen werden können. Der folgende Artikel zeigt, dass schon ein überschaubarer zeitlicher Ausschnitt aus der Chamisso-Literatur eine große Menge an Aussagen zur deutschen Sprache liefert. Ein größeres oder sogar vollständiges Bild wäre daher höchstens in einer umfangreicheren Arbeit zu zeichnen möglich. Zunächst soll nun dargestellt werden, weshalb es sich lohnen könnte, sich mit Aussagen von Chamisso-Literatur-Verfassenden bzw. -Preistragenden zur deutschen Sprache zu beschäftigen (Kap. 1, bevor die Zitate geordnet nach linguistischen (Kap. 2 und anthropologischen (Kap. 3 Beschreibungskategorien dargestellt werden und schließlich nach einer kurzen Zusammenfassung (Kap. 4.1 ein Ausblick gewagt wird (Kap. 4.2. As it is possible to draw interesting conclusions from remarks of Chamisso-authors about the German language, the following article presents a collection of corresponding citations from works published between 2003 and 2013 of authors, who have been awarded with the Chamisso-Award. Citations are sorted by linguistic and anthropological topics. The chosen decade can be considered representative, because it shows a time period, when many of the Chamisso-Awardees did actually publish their works. It is therefore very suitable to show, which kinds of remarks about the German language can be found in Chamisso-literature. The

  20. Numerical study of groundwater flow cycling controlled by seawater/freshwater interaction in a coastal karst aquifer through conduit network using CFPv2

    Science.gov (United States)

    Xu, Zexuan; Hu, Bill X.; Davis, Hal; Kish, Stephen

    2015-11-01

    In this study, a groundwater flow cycling in a karst springshed and an interaction between two springs, Spring Creek Springs and Wakulla Springs, through a subground conduit network are numerically simulated using CFPv2, the latest research version of MODFLOW-CFP (Conduit Flow Process). The Spring Creek Springs and Wakulla Springs, located in a marine estuary and 11 miles inland, respectively, are two major groundwater discharge spots in the Woodville Karst Plain (WKP), North Florida, USA. A three-phase conceptual model of groundwater flow cycling between the two springs and surface water recharge from a major surface creek (Lost Creek) was proposed in various rainfall conditions. A high permeable subground karst conduit network connecting the two springs was found by tracer tests and cave diving. Flow rate of discharge, salinity, sea level and tide height at Spring Creek Springs could significantly affect groundwater discharge and water stage at Wakulla Springs simultaneously. Based on the conceptual model, a numerical hybrid discrete-continuum groundwater flow model is developed using CFPv2 and calibrated by field measurements. Non-laminar flows in conduits and flow exchange between conduits and porous medium are implemented in the hybrid coupling numerical model. Time-variable salinity and equivalent freshwater head boundary conditions at the submarine spring as well as changing recharges have significant impacts on seawater/freshwater interaction and springs' discharges. The developed numerical model is used to simulate the dynamic hydrological process and quantitatively represent the three-phase conceptual model from June 2007 to June 2010. Simulated results of two springs' discharges match reasonably well to measurements with correlation coefficients 0.891 and 0.866 at Spring Creeks Springs and Wakulla Springs, respectively. The impacts of sea level rise on regional groundwater flow field and relationship between the inland springs and submarine springs are

  1. Numerical study of groundwater flow cycling controlled by seawater/freshwater interaction in a coastal karst aquifer through conduit network using CFPv2.

    Science.gov (United States)

    Xu, Zexuan; Hu, Bill X; Davis, Hal; Kish, Stephen

    2015-11-01

    In this study, a groundwater flow cycling in a karst springshed and an interaction between two springs, Spring Creek Springs and Wakulla Springs, through a subground conduit network are numerically simulated using CFPv2, the latest research version of MODFLOW-CFP (Conduit Flow Process). The Spring Creek Springs and Wakulla Springs, located in a marine estuary and 11 miles inland, respectively, are two major groundwater discharge spots in the Woodville Karst Plain (WKP), North Florida, USA. A three-phase conceptual model of groundwater flow cycling between the two springs and surface water recharge from a major surface creek (Lost Creek) was proposed in various rainfall conditions. A high permeable subground karst conduit network connecting the two springs was found by tracer tests and cave diving. Flow rate of discharge, salinity, sea level and tide height at Spring Creek Springs could significantly affect groundwater discharge and water stage at Wakulla Springs simultaneously. Based on the conceptual model, a numerical hybrid discrete-continuum groundwater flow model is developed using CFPv2 and calibrated by field measurements. Non-laminar flows in conduits and flow exchange between conduits and porous medium are implemented in the hybrid coupling numerical model. Time-variable salinity and equivalent freshwater head boundary conditions at the submarine spring as well as changing recharges have significant impacts on seawater/freshwater interaction and springs' discharges. The developed numerical model is used to simulate the dynamic hydrological process and quantitatively represent the three-phase conceptual model from June 2007 to June 2010. Simulated results of two springs' discharges match reasonably well to measurements with correlation coefficients 0.891 and 0.866 at Spring Creeks Springs and Wakulla Springs, respectively. The impacts of sea level rise on regional groundwater flow field and relationship between the inland springs and submarine springs are

  2. Sexual Function after Non-Nerve-Sparing Radical Cystoprostatectomy: A Comparison between Ileal Conduit Urinary Diversion and Orthotopic Ileal Neobladder Substitution

    Directory of Open Access Journals (Sweden)

    M.A Asgari

    2013-07-01

    Full Text Available Objective To compare the erectile function (EF and sexual desire (SD in men after radical cystoprostatectomy (RCP who had either an ileal conduit urinary diversion or orthotropic ileal neobladder substitution. Materials and Methods Eighty one sexually active men with bladder cancer were enrolled in this prospective study. After RCP according to patients' preferences they underwent either ileal conduit urinary diversion (n = 41 or orthotropic ileal neobladder substitution (n = 40. EF and SD were assessed using International Index of Erectile Function (IIEF questionnaire. Patients were assessed at 4-week before surgery and were followed up at 1, 6, and 12-month postoperatively using the same questionnaire. Results Postoperatively the EF and SD domains deteriorated significantly in both groups, but in a small proportion of the patients submitted to ileal neobladder they gradually improved with time (P = 0.006. At 12-month postoperative period, 4 (9.8% and 14 (35.0% patients in ileal conduit and ileal neobladder groups were able to achieve erections hard enough for vaginal penetration and maintained their erection to completion of intercourse, respectively (P = 0.006. Among patients in the ileal conduit and ileal neobladder groups, additional 4 (9.8% and 7 (17.1% patients were able to get some erection, but were unable to maintain their erection to completion of intercourse (P = 0.02. At 12-month follow up period 24.4% of the ileal conduit and 45.0% of the ileal neobladder patients rated their sexual desire very high or high (P = 0.01. Conclusion When performed properly, orthotopic ileal neobladder substitution after RCP offers better long-term results in terms of EF and SD.

  3. The efficacy of a scaffold-free Bio 3D conduit developed from human fibroblasts on peripheral nerve regeneration in a rat sciatic nerve model.

    Directory of Open Access Journals (Sweden)

    Hirofumi Yurie

    Full Text Available Although autologous nerve grafting is the gold standard treatment of peripheral nerve injuries, several alternative methods have been developed, including nerve conduits that use supportive cells. However, the seeding efficacy and viability of supportive cells injected in nerve grafts remain unclear. Here, we focused on a novel completely biological, tissue-engineered, scaffold-free conduit.We developed six scaffold-free conduits from human normal dermal fibroblasts using a Bio 3D Printer. Twelve adult male rats with immune deficiency underwent mid-thigh-level transection of the right sciatic nerve. The resulting 5-mm nerve gap was bridged using 8-mm Bio 3D conduits (Bio 3D group, n = 6 and silicone tube (silicone group, n = 6. Several assessments were conducted to examine nerve regeneration eight weeks post-surgery.Kinematic analysis revealed that the toe angle to the metatarsal bone at the final segment of the swing phase was significantly higher in the Bio 3D group than the silicone group (-35.78 ± 10.68 versus -62.48 ± 6.15, respectively; p < 0.01. Electrophysiological studies revealed significantly higher compound muscle action potential in the Bio 3D group than the silicone group (53.60 ± 26.36% versus 2.93 ± 1.84%; p < 0.01. Histological and morphological studies revealed neural cell expression in all regions of the regenerated nerves and the presence of many well-myelinated axons in the Bio 3D group. The wet muscle weight of the tibialis anterior muscle was significantly higher in the Bio 3D group than the silicone group (0.544 ± 0.063 versus 0.396 ± 0.031, respectively; p < 0.01.We confirmed that scaffold-free Bio 3D conduits composed entirely of fibroblast cells promote nerve regeneration in a rat sciatic nerve model.

  4. Comparison of Fiber Optic and Conduit Attenuated Total Reflection (ATR) Fourier Transform Infrared (FT-IR) Setup for In-Line Fermentation Monitoring.

    Science.gov (United States)

    Koch, Cosima; Posch, Andreas E; Herwig, Christoph; Lendl, Bernhard

    2016-12-01

    The performance of a fiber optic and an optical conduit in-line attenuated total reflection mid-infrared (IR) probe during in situ monitoring of Penicillium chrysogenum fermentation were compared. The fiber optic probe was connected to a sealed, portable, Fourier transform infrared (FT-IR) process spectrometer via a plug-and-play interface. The optical conduit, on the other hand, was connected to a FT-IR process spectrometer via a knuckled probe with mirrors that had to be adjusted prior to each fermentation, which were purged with dry air. Penicillin V (PenV) and its precursor phenoxyacetic acid (POX) concentrations were determined by online high-performance liquid chromatography and the obtained concentrations were used as reference to build partial least squares regression models. Cross-validated root-mean-square errors of prediction were found to be 0.2 g L -1 (POX) and 0.19 g L -1 (PenV) for the fiber optic setup and 0.17 g L -1 (both POX and PenV) for the conduit setup. Higher noise-levels and spectrum-to-spectrum variations of the fiber optic setup lead to higher noise of estimated (i.e., unknown) POX and PenV concentrations than was found for the conduit setup. It seems that trade-off has to be made between ease of handling (fiber optic setup) and measurement accuracy (optical conduit setup) when choosing one of these systems for bioprocess monitoring. © The Author(s) 2016.

  5. Logfile-Analysen zur Evaluation der didaktischen Einbettung von CSCL-Systemen - am Beispiel der CommSy-Nutzung in offenen Seminaren

    Directory of Open Access Journals (Sweden)

    Martin Klein

    2005-02-01

    Full Text Available In unserem Beitrag evaluieren wir die didaktische Einbettung einer CSCL-Anwendung anhand von Logfile-Analysen. Dazu betrachten wir exemplarisch die Nutzung des webbasierten Systems CommSy in einer projektorientierten Lehrveranstaltung, die wir als offenes Seminar charakterisieren. Wir erzielen zwei Ergebnisse: (1 Wir geben Hinweise zur Gestaltung des Nutzungskontexts eines CSCL-Systems sowie zur Unterstützung seiner anfänglichen und kontinuierlichen Nutzung. (2 Wir beschreiben die Analyse von Nutzungsanlässen und -mustern sowie von NutzerInnentypen anhand von Logfiles. Dabei können Logfile-Analysen zur Validierung weiterer Evaluationsergebnisse dienen, sind selbst jedoch nur in Kombination mit zusätzlichen Informationen zum Nutzungskontext interpretierbar.

  6. Hints on cost- and energy saving during lime-sand brick production; Hinweise zur Kosten- und Energieeinsparung bei der Kalksandstein-Produktion

    Energy Technology Data Exchange (ETDEWEB)

    Eden, W.

    2001-05-01

    The publication contains hints for reduction of energy consumption and cost in lime-sand brick production. The information was compiled by Bundesverband Kalksandsteinindustrie e.V. and was derived from technical discussions of the master seminars on production technology of the years 1995 - 2000, consultations form member organizations, or from other sources. [German] Diese Arbeit ist eine Zusammenstellung von Hinweisen zur Reduzierung des Energieverbrauchs und der Kostensenkung bei der KS-Produktion und soll eine Hilfestellung bei entsprechenden Rationalisierungsmassnahmen in den Mitgliedsunternehmen sein. Die hier aufgefuehrten Hinweise und Anregungen entstammen den Fachdiskussionen der Meisterseminare zur Produktionstechnik aus den Jahren 1995 bis 2000, Beratungsgespraechen fuer Mitgliedsunternehmen oder wurden dem Bundesverband Kalksandsteinindustrie eV freundlicherweise fuer die Gemeinschaftsarbeit zur Verfuegung gestellt. (orig.)

  7. Studien zur Messung von Rekonstruktionseffizienz und Untergrund der $\\tau$-Lepton-Identifikation im Zerfall $Z\\to \\tau \\tau$ beim ATLAS-Experiment aus Daten

    CERN Document Server

    Johnert, Sebastian

    2008-01-01

    In dieser Diplomarbeit werden zwei Methoden vorgestellt, mit denen τ -Leptonen in den zuk ̈nf- u tigen Daten des ATLAS-Experiments untersucht werden sollen. Den ersten Teil bildet die Be- stimmung von Missidentifikationsraten von Jets aus QCD-2-Jet-Ereignissen als τ -Leptonen. Der zweite Teil ist die Entwicklung einer Methode zur Bestimmung der τ -Rekonstruktions- und -Identifikationseffizienz relativ zur μ-Effizienz. In diesem Zusammenhang werden invariante Massen aus Z → ll-Ereignissen bestimmt, die Massen aus Z → τ τ -Ereignissen mit denen aus Z → ee und Z → μμ verglichen, τ -Effizienzen gemittelt uber alle Bereiche und in verschiedenen ̈ o η-Bereichen berechnet sowie eine M ̈glichkeit zur Bestimmung von τ -Effizienzen in unterschied- lichen Transversalimpulsbereichen vorgestellt. Des Weiteren wird eine verbesserte Absch ̈tzung a des QCD-Untergrunds vorgenommen und das Verhalten der τ -Effizienz unter Ber ̈cksichtigung u des Triggers untersucht.

  8. Balancing and dynamic behaviour of a biofilter plant for complete cleaning of municipal sewage; Bilanzierung und dynamisches Verhalten einer Biofilteranlage zur Vollreinigung von kommunalem Abwasser

    Energy Technology Data Exchange (ETDEWEB)

    Dickgreber, M.; Luebbecke, S. [Preussag Wassertechnik GmbH, Bremen (Germany)

    1999-07-01

    Where municipal sewage treatment plants need to be extended or enlarged, biofilter systems represent an economical alternative. They can be used both for supplementary residual elimination purposes and to treat complete sewage streams. For a biofilter system for complete cleaning of sewage employing the DENIPOR trademark -NCS process which has been in operation since 1996 (2*500 population value), studies in process dynamics are carried out and a complete balance is set up. (orig.) [German] Biofilter stellen bei notwendigen Erweiterungen und Ausbaumassnahmen von kommunalen Klaeranlagen eine wirtschaftliche Alternative dar. Sie koennen fuer weitergehende Restreinigungsaufgaben und zur Vollstrombehandlung eingesetzt werden. An einer seit 1996 in Betrieb befindlichen Biofilteranlage zur Vollreinigung von kommunalem Abwasser nach dem DENIPOR {sup trademark} -NCS Verfahren (2*500EW) werden Untersuchungen zur Prozessdynamik sowie eine vollstaendige Bilanzierung durchgefuehrt. (orig.)

  9. Magnetic resonance tomography-guided interventional procedure for diagnosis of prostate cancer; MRT-gezielte interventionelle Verfahren zur Abklaerung des Prostatakarzinoms

    Energy Technology Data Exchange (ETDEWEB)

    Schernthaner, M.; Helbich, T.H.; Fueger, B.J.; Memarsadeghi, M.; Stiglbauer, A.; Linhart, H.G.; Doan, A.; Pinker, K.; Brader, P. [Medizinische Universitaet Wien, Univ.-Klinik fuer Radiodiagnostik, Division fuer Molekulare und Gender-Bildgebung, Wien (Austria); Margreiter, M. [Medizinische Universitaet Wien, Univ.-Klinik fuer Urologie, Wien (Austria)

    2011-11-15

    In recent years magnetic resonance imaging (MRI) has been increasingly established in the diagnosis of prostate cancer in addition to transrectal ultrasonography (TRUS). The use of T2-weighted imaging allows an exact delineation of the zonal anatomy of the prostate and its surrounding structures. Other MR imaging tools, such as dynamic contrast-enhanced T1-weighted imaging or diffusion-weighted imaging allow an inference of the biochemical characteristics (multiparametric MRI). Prostate cancer, which could only be diagnosed using MR imaging or lesions suspected as being prostate cancer, which are localized in the anterior aspect of the prostate and were missed with repetitive TRUS biopsy, need to undergo MR guided biopsy. Recent studies have shown a good correlation between MR imaging and histopathology of specimens collected by MR-guided biopsy. Improved lesion targeting is therefore possible with MR-guided biopsy. So far data suggest that MR-guided biopsy of the prostate is a promising alternative diagnostic tool to TRUS-guided biopsy. (orig.) [German] Neben dem transrektalen Ultraschall (TRUS) hat sich in den letzten Jahren die MRT als nichtinvasive Methode zur Bildgebung von Prostatatumoren etabliert. Mittels T2-gewichteter Sequenzen ist eine exakte anatomische Darstellung der Prostata und ihrer umliegenden Strukturen moeglich. Andere MRT-Techniken ermoeglichen Rueckschluesse auf das biologische Verhalten des Tumors: dynamische kontrastmittelverstaerkte T1-gewichtete Sequenzen zur Darstellung der Angiogenese, diffusionsgewichtete Aufnahmen zur Beurteilung der Zelldichte und die Spektroskopie zur Bestimmung von Gewebemetaboliten wie Cholin und Kreatin (multiparametrische Bildgebung). Prostatatumoren, die nur mittels MRT nachweisbar sind oder verdaechtige Tumoren, die hauptsaechlich anterior in der Prostata lokalisiert sind und in wiederholten TRUS-gezielten Biopsien verfehlt wurden, benoetigen eine MRT-gezielte Biopsie zur Diagnosesicherung. Die bisherigen

  10. Umfrage zur RDA-Einführung in der Universitätsbibliothek Trier

    Directory of Open Access Journals (Sweden)

    Birgit Unkhoff-Giske

    2018-03-01

    Full Text Available Nach fast einem Jahr praktischer Erfahrung mit dem neuen Regelwerk wurde in der Universitätsbibliothek Trier eine Umfrage zur Einführung von „Resource Description and Access (RDA“ durchgeführt. Dabei ging es um den Katalogisierungsalltag: die Sicherheit im Umgang mit RDA und dem Toolkit, die Informationsversorgung, Änderungen beim Arbeitsaufwand, die Bewertung der RDA-Regelungen, insbesondere des neuen Prinzips „Cataloguer’s judgement“ und die persönliche Einstellung gegenüber dem Regelwerksumstieg. Die Ergebnisse der 20 Fragen werden im folgenden Beitrag vorgestellt und analysiert. Die Umfrage führte zu überraschend positiven Erkenntnissen, deckte aber auch Problemfelder auf, die der Nachbearbeitung bedürfen. After almost a year of practical experience with the new cataloguing standard, a survey on the implementation of “Resource Description and Access (RDA” was carried out at the University Library of Trier. It focused on everyday cataloguing: the confidence in dealing with RDA and the Toolkit, the supply of information, changes in the amount of work, the evaluation of the RDA rules, in particular the new principle “cataloguer’s judgement”, and the personal attitudes towards the change of the cataloguing code. The results of the 20 questions are presented and analysed in the following article. The survey led to surprisingly positive findings, but also uncovered problem areas that require follow-up work.

  11. Gabriele Winker, Nina Degele: Intersektionalität. Zur Analyse sozialer Ungleichheiten. Bielefeld: transcript Verlag 2009.

    Directory of Open Access Journals (Sweden)

    Heike Kahlert

    2010-03-01

    Full Text Available Gabriele Winker und Nina Degele legen mit ihrer kompakten Monographie erstmals für den deutschsprachigen Raum eine in Theorie, Methodologie und Empirie stringente eigenständige Abhandlung zur intersektionalen Analyse von sozialen Ungleichheiten vor. Das in jeder Hinsicht übersichtlich gestaltete Buch besticht durch eine begründete Argumentation, insbesondere in Bezug auf die theoretischen Vorentscheidungen, durch eine klare Gliederung und vor allem durch die Schritt für Schritt nachvollziehbare Umsetzung des vorgeschlagenen theoretischen und methodologischen Rahmens in die empirische Sozialforschung. Es ist daher uneingeschränkt empfehlenswert, auch für den Einsatz in der Hochschullehre, und es ist von hohem Anregungspotential für die wissenschaftliche Weiterentwicklung intersektionaler Analysen von sozialen Ungleichheiten.This compact monograph by Gabriele Winker and Nina Degele, intended for a German-speaking readership, provides a theoretically, methodologically, and empirically stringent as well as independent critique of intersectional analysis of social inequalities. The book, which is in every sense clearly organized, is striking because of its well-founded argumentation (especially in terms of the authors’ theoretical decisions, its clear structure, and most notably its step-by-step and comprehensible application of the suggested theoretical and methodological framework for empirical social research. The book is thus recommended without reserve, also for use in higher education, and it has the potential to inspire further scientific development of intersectional analysis of social inequities.

  12. [COPD und Klangtherapie: Pilotstudie zur Wirksamkeit einer Behandlung mit Körpertambura bei COPD-Patienten].

    Science.gov (United States)

    Hartwig, Bernhard; Schmidt, Stefan; Hartwig, Isabella

    2016-01-01

    Hintergrund: Erkrankungen der Atemorgane treten mit steigendem Alter öfter auf, nehmen weltweit zu und sind häufige Ursachen für Morbidität und Mortalität. In dieser Pilotstudie wurde der Frage nachgegangen, ob eine einmalige 10-minütige Behandlung mit einer Körpertambura eine signifikante und effektive Verbesserung der Lungenfunktion von Patienten mit chronisch-obstruktiver Lungenerkrankung (COPD; GOLD-Stadium A oder B) erbringen kann. Patienten und Methoden: 54 Probanden konnten je zur Hälfte in eine Behandlungsgruppe (Körpertambura) und eine aktive Kontrollgruppe (Atemtherapie) randomisiert werden. Eine Bestimmung der Lungenfunktionsmessparameter «Einsekundenkapazität» (FEV1) und «inspiratorische Vitalkapazität» (IVC) zu den Zeitpunkten T1 (Baseline), T2 (direkt nach Behandlung) und als Follow-up etwa 3 Wochen nach T1 (T3). Ergebnisse: Die Behandlungsgruppe zeigte sich der Kontrollgruppe in beiden Werten signifikant überlegen. Die Zeit-×-Gruppe-Interaktion (Varianzanalyse) ergab p = 0,001 (FEV1) bzw. p = 0,04 (IVC). Die Behandlungsgruppe zeigte bei beiden Werten eine Verbesserung von klinischer Relevanz. Schlussfolgerung: Diese Ergebnisse zeigen, dass die Klangbehandlung mittels einer Körpertambura - neben den schulmedizinischen, leitliniengerechten Therapien - eine zusätzliche, nebenwirkungsarme, aber durchaus klinisch wirksame Option für die Behandlung von COPD-Patienten darstellen kann, um deren Lebensqualität zu stabilisieren und zu verbessern. © 2016 S. Karger GmbH, Freiburg.

  13. Einstellung und Wissen von Lehramtsstudierenden zur Evolution - ein Vergleich zwischen Deutschland und der Türkei

    Science.gov (United States)

    Graf, Dittmar; Soran, Haluk

    Es wird eine Untersuchung vorgestellt, in der Wissen und Überzeugungen von Lehramtsstudierenden aller Fächer zum Thema Evolution an zwei Universitäten in Deutschland und der Türkei erhoben worden sind. Die Befragung wurde in Dortmund und in Ankara durchgeführt. Es stellte sich heraus, dass ausgeprägte Defizite im Verständnis der Evolutionsmechanismen herrschen. Viele Studierende, insbesondere aus der Türkei, sind nicht von der Faktizität der Evolution überzeugt. Dies gilt sowohl für Studierende mit Fach Biologie als auch für Studierende mit anderen Fächern. Näher untersucht worden sind die Faktoren, die die Überzeugungen zur Evolution beeinflussen können, was ja in Anbetracht der hohen Ablehnungsrate der Evolution von besonderem Interesse ist. Das Vertrauen in die Wissenschaft spielt hierbei eine besondere Rolle: Wer der Wissenschaft vertraut, ist auch eher von der Evolution überzeugt, als diejenigen, die skeptisch gegenüber der Wissenschaft sind.

  14. Das Symbolische zwischen Struktur und Handlung Anmerkungen zur Diskussion des Symbols in der Wissenschaftsgeschichte Frankreichs

    Directory of Open Access Journals (Sweden)

    Wolfgang Neurath

    2015-09-01

    Full Text Available Noch nie war Politik symbolischer als in Zeiten der Krise; es wird daher immer drängender sich der Frage zu stellen, ob die symbolischen Ordnungen mit denen wir tagtäglich konfrontiert sind, zur "Wahl" stehen, d. h. durch politische Handlungen erneuert werden müssen und damit auch veränderbar sind, oder ob symbolische Ordnungen in gewisser Weise auf uns zukommen und es nur darum gehen kann, an einer strukturellen Ereignishaftigkeit oder an Fluchtlinien zu partizipieren, die von den nicht geglückten symbolischen Übersetzungen ermöglicht/erzwungen werden, die sich durch die Funktionsweise des Symbolischen selbst ergeben (Loïc Wacquant hat dies das autotelische Wirken einer semiotischen Algebra genannt. Dadurch spaltet sich der Raum des Politischen vorerst in ein symbolisches Funktionssystem und in Symbolisierungen von nicht geglückten Übersetzungen auf. Diese Frage nach dem Status und der Politik des "Symbolischen" wurde in den 70er Jahren des letzten Jahrhunderts in Frankreich intensiv und unablässig gestellt und man kann mit Fug und Recht behaupten, dass das strukturale Denksystem durchaus zum Tanzen gebracht wurde und durch die Arbeit an Begriff wie Konzept des Symbolischen eine äußerst schillernde Ambiguität aufzutauchen beginnt.

  15. Ganzheitliche Digitalisierungsansätze im Stadtwerk: Von der Strategie bis zur Umsetzung

    Science.gov (United States)

    Dudenhausen, Roman; Hahn, Heike

    Digitalisierung muss im Stadtwerk dazu führen, Kundenerwartungen, die heutzutage schon vielfach durch digitales Know-how und Erfahrungen geprägt sind, in einzigartiger Weise zu entsprechen - in Form digitaler Kundenkontaktpunkte, automatisierter Prozesse oder plattformbasierter Geschäftsmodelle. Eine große Rolle spielen dabei unternehmensweit nutzbare Informationen, die eine 360-Grad-Sicht auf den Kunden ermöglichen. Nur in dieser Kombination werden sich nachhaltig Wettbewerbsvorteile generieren lassen. Manch ein Kunde wird die Lust, einen Prozess zu Ende zu gehen, schon vor dem Abschluss verlieren, wenn er nicht unmittelbar und ohne die digitale Welt zu verlassen zum Ziel kommt. Eine nur "halb digitale Kundenerfahrung" wird weder zu Neugeschäft noch zur positiven emotionalen Bindung zwischen Kunden und Stadtwerk führen. Nicht zu unterschätzen sind zudem Erwartungen hinsichtlich zukünftiger Geschäftsmodelle, aus denen sich disruptive Bedrohungen für die herkömmlichen Strom- und Gasangebote ergeben werden. Erste innovative Ansätze finden sich bereits im Markt, die erahnen lassen, dass zurzeit viel diskutierte Technologien wie die Blockchain nicht mehr nur hypothetischer Natur sind. Die Auseinandersetzung mit der Digitalisierung erfolgt dabei sinnvollerweise in einem unternehmensweit abgestimmten Rahmen, der eine zielgerichtete und ganzheitliche Vorgehensweise ermöglicht.

  16. Indications for fetal magnetic resonance imaging (MRI); Indikationen zur fetalen Magnetresonanztomographie

    Energy Technology Data Exchange (ETDEWEB)

    Prayer, D. [Medizinische Universitaet Wien (Austria). Klinik fuer Radiodiagnostik; Brugger, P.C. [Zentrum fuer Anatomie und Zellbiologie der Medizinischen Universitaet Wien (Austria). Arbeitsgruppe Integrative Morphologie; Krampl, E. [Medizinische Universitaet Wien (Austria). Klinik fuer Gynaekologie und Geburtshilfe; Prayer, L. [Diagnosezentrum Urania, Wien (Austria)

    2006-02-15

    Indications to perform fetal magnetic resonance imaging (MRI) are composed of common ones related to methodological problems of ultrasound (US) assessment (such as for instance hydramnios) and special ones. The latter are related to MR capability of high-resolution soft tissue contrast and an extended field of view that allows visualization of the whole fetus, even in later stages of pregnancy. The most important indications include confirmation of US findings, work-up of malformations with respect to individual prognosis and genetic background, differentiation between acquired conditions and malformations, visualization of pathologies that have to be treated surgically immediately after birth, and morphological changes of the placenta. (orig.) [German] Indikationen zur Durchfuehrung einer fetalen Magnetresonanztomographie (MRT) setzen sich aus allgemeinen Fragestellungen zusammen, die auf methodischen Problemen von Ultraschalluntersuchungen (US) beruhen (wie beispielsweise Anhydramnion), und speziellen, bei denen die MR-Eigenschaften der hochaufloesenden Gewebedifferenzierung und eines Untersuchungsfensters, das eine Abbildung des gesamten Fetus auch im fortgeschrittenen Schwangerschaftsalter erlaubt, ausgenuetzt werden. Im Vordergrund stehen dabei die Absicherung von US-Befunden, die Abklaerung von Fehlbildungen in Hinblick auf individuelle Prognose und Vorliegen eines Syndroms mit genetisch determiniertem Hintergrund, und die Differenzierung erworbener Stoerungen von Fehlbildungen, die Abklaerung von Veraenderungen, die einer unmittelbar postnatalen operativen Therapie beduerfen, und morphologischer Veraenderungen der Plazenta. (orig.)

  17. Discussion of the applicability of overdammed fixed-bed reactors in nitrification processes; Beitrag zum Einsatz von ueberstauten Festbettreaktoren zur Nitrifikation

    Energy Technology Data Exchange (ETDEWEB)

    Guenter, H.O.

    1996-12-31

    The investigation aimed at developing a dimensioning method for overdammed fixed bed nitrification reactors with plug flow which takes account of the reactor height. Further, information was to be obtained for assessing sudden loads and for comparing energy consumption with the data of conventional activated sludge plants. (orig./SR) [Deutsch] Ziel dieser Arbeit ist es, fuer ueberstaute, pfropfendurchstroemte Festbettreaktoren zur Nitrifikation einen Bemessungsansatz aufzustellen, welcher den Einfluss der Reaktorhoehe mit beruecksichtigt. Ferner sollten Erkenntnisse zur Beurteilung von Stossbelastungen sowie zum Energiebedarf im Vergleich zu herkoemmlichen Belebungsanlagen gewonnen werden. (orig./SR)

  18. The 2006 Eruption of Raoul Volcano (Kermadecs): A Phreato-magmatic Event From a Hydrothermally-Sealed Volcanic Conduit System.

    Science.gov (United States)

    Christenson, B. W.; Reyes, A. G.; Werner, C. A.

    2006-12-01

    The March 17, 2006 eruption from Raoul volcano (Kermadec Islands, NZ), which tragically claimed the life of NZ Department of Conservation staff member Mark Kearney, is being interpreted as a magmatic-hydrothermal event triggered by shaking associated with regional earthquake swarm activity. Although the eruption released ca. 200 T of SO2, thus confirming its magmatic nature, it occurred without significant precursory volcanic seismicity, and without any of the precursory responses of the volcanic hydrothermal system which were observed prior to the last eruption in 1964. Raoul Island has a long and varied eruption history dating back > 1.4 ma, and has been hydrothermally active throughout historic time. Present day fumarolic and hotspring discharges within Raoul caldera point to the existence of a small but well established, mixed meteoric - seawater hydrothermal system within the volcano. Magmatic signatures are apparent in fumarolic gas discharges, but are heavily masked by their interaction with hydrothermal system fluids (eg. near complete scrubbing of sulphur and halogen gases from the boiling point fumarolic discharges). A diffuse degassing study conducted in 2004 revealed that ca. 80 T/d CO2 is passively discharged from the volcano, suggesting that ongoing (albeit low level) convective degassing of magma occurs at depth. Interestingly, vent locations from the 2006 eruption correspond to areas of relatively low CO2 discharge on the crater floor in 2004. This, in conjunction with the preliminary findings of abundant hydrothermal mineralisation (calcite, anhydrite, quartz) in eruption ejecta, suggests that the main volcanic conduits had become effectively sealed during the interval since the last eruption. Calcite-hosted fluid inclusions are CO2 clathrate-bearing, and have relatively low homogenisation temperatures (165-180 °C), suggesting that the seal environment was both gas-charged and shallowly seated (< 200 m). Shaking associated with the regional

  19. Thermal Expansivity Between 150 and 800°C of Hydrothermally Altered Conduit Dyke Samples from USDP-4 Drill Core (Mt Unzen, Shimabara, Japan)

    Science.gov (United States)

    Yilmaz, T. I.; Hess, K. U.; Vasseur, J.; Wadsworth, F. B.; Gilg, H. A.; Nakada, S.; Dingwell, D. B.

    2017-12-01

    When hot magma intrudes the crust, the surrounding rocks expand. Similarly, the cooling magma contracts. The expansion and contraction of these multiphase materials is not simple and often requires empirical constraint. Therefore, we constrained the thermal expansivity of Unzen dome and conduit samples using a NETZSCH® DIL 402C. Following experiments, those samples were scanned using a Phoenix v|tome|x m to observe the cracks that may have developed during the heating and cooling. The dome samples do not show petrological or chemical signs of alteration. However, the alteration of the conduit dykes is represented by the occurrence of the main secondary phases such as chlorite, sulfides, carbonates, R1 (Reichweite parameter) illite-smectite, and kaolinite. These alteration products indicate an (I) early weak to moderate argillic magmatic alteration, and a (II) second stage weak to moderate propylitic hydrothermal alteration. The linear thermal expansion coefficient aL of the dome material is K-1 between 150° and 800°C and shows a sharp peak of up to K-1 around the alpha-beta-quartz-transition ( 573°C). In contrast, aL of the hydrothermally altered conduit samples starts to increase around 180° and reaches K-1 at 400°C. We interpret this effect as being due to the water content of the kaolinite and the R1 illite-smectite, which induces larger expansions per degree temperature change. Furthermore, the altered conduit samples show a more pronounced increases of aL between 500 and 650°C of up to peaks at K-1, which is generated by the breakdown of chlorite, iron-rich dolomite solid solutions, calcite, and pyrite. We use a 1D conductive model of heat transfer to explore how the country rock around the Unzen conduit zone would heat up after intrusion. In turn, we convert these temperature profiles to thermal stress profiles, assuming the edifice is largely undeformable. We show that these high linear thermal expansion coefficients of the hydrothermally altered

  20. What goes up might come down: Backflow in the conduits of persistently degassing volcanoes and ramifications for melt-inclusion analysis

    Science.gov (United States)

    Suckale, J.; Qin, Z.; Picchi, D.; Keller, T.

    2017-12-01

    Many active volcanoes erupt significantly less magma than they degas, implying that large quantities of magma must descend back into the plumbing system after degassing. The resulting bidirectional flow field in the volcanic conduit is fundamentally unstable. These instabilities are important to understand, because they likely control the episodicity of eruptive behavior observed at persistently degassing volcanoes. Laboratory experiments have provided invaluable insights into the flow regimes that may arise in volcanic conduits, but are not straightforward to scale up to volcanic systems. The goal of this study is to use direct numerical simulations to virtually reproduce the analogue experiments by Stevenson and Blake, 1998, compare them to simple analytical models and gain insights into the different flow regimes and interface instabilities observed in actual volcanic conduits. Direct numerical simulations provide a compelling complement to analogue experiments, because they are not constrained by the scales or flow properties achievable in a laboratory setting. By linking virtual and analogue experiments, we show that the interface between ascending and descending fluid is not usually stationary in volcanic conduits (see fig). The intuition that buoyant, volatile-rich magma moves up while heavy, degassed magma moves down is hence not generally true in bidirectional conduit flow. Instead, our results show that a potentially significant portion of the volatile-rich magma flows downwards despite its positive buoyancy - a process commonly referred to as backflow. The existence of backflow in volcanic conduits has potentially important ramifications for understanding melt-inclusion trends, because it affects exsolved and dissolved volatile components differently. Our preliminary results suggest that carbon dioxide bubbles exsolved at depth tend to decouple from the backflow and escape into the upward moving portion of the fluid, while dissolved water is recycled

  1. Evaluation der Kurse 'Deutsch als Fremdsprache' im Akademischen Auslandsamt Siegen : ein Beitrag zur Qualitätssicherung und -entwicklung

    OpenAIRE

    Moll, Katharina

    2011-01-01

    Der Begriff "Qualität" im Kontext von Lehre und Unterricht ist schon seit Jahren in aller Munde. Nicht erst, aber insbesondere seit der Veröffentlichung der ersten PISA-Studie fordern Politiker umfassende Managementsysteme zur Verbesserung der Qualität von Bildungseinrichtungen in Deutschland. In diesem Zusammenhang wurden in den letzten Jahren viele Ideen entwickelt, die helfen sollen, die Qualität der Bildung zu verbessern. Vor allem für den schulischen Bereich, der besonders unter Druck ge...

  2. Anforderungen an ein System zur Dokumentanalyse im Unternehmenskontext : Integration von Datenbeständen, Aufbau- und Ablauforganisation

    OpenAIRE

    Baumann, Stephan; Hadj Ali, Majdi Ben; Lichter, Jürgen; Malburg, Michael; Meyer auf'm Hofe, Harald; Wenzel, Claudia

    1997-01-01

    Workflowmanagementsysteme werden im Bürobereich verstärkt zur effizienten Geschäftsprozeßabwicklung eingesetzt. Das bereits Mitte der 70er Jahre propagierte papierlose Büro bleibt jedoch gegenwärtig immer noch Utopie, da auch durch den allgegenwärtigen Einsatz von Computern im Bürobereich der Durchsatz an Schriftstücken nicht gesenkt wird. Insbesondere die Handhabung von papierintensiven Vorgängen ist in hohem Maße abhängig von einer Identifikation und Aufbereitung der in den Dokumenten e...

  3. Architektur für ein System zur Dokumentanalyse im Unternehmenskontext - Integration von Datenbeständen, Aufbau- und Ablauforganisation

    OpenAIRE

    Baumann, Stephan; Lichter, Jürgen; Malburg, Michael; Maus, Heiko; Meyer auf´m Hofe, Harald; Wenzel, Claudia

    1998-01-01

    Workflowmanagementsysteme werden im Bürobereich verstärkt zur effizienten Geschäftsprozeßabwicklung eingesetzt. Das bereits Mitte der 70er Jahre propagierte papierlose Büro bleibt jedoch gegenwärtig immer noch Utopie. Dieser Widerspruch liegt darin begründet, daß die Handhabung von papierintensiven Vorgängen in hohem Maße abhängig ist von einer Identifkation und Aufbereitung der in den Dokumenten enthaltenen Informationen. Allerdings müssen solche Daten z.B. bei eingehender Post immer noch v...

  4. Role of imaging procedures in clarification of complications of pneumonia; Rolle der bildgebenden Verfahren zur Abklaerung von Pneumoniekomplikationen

    Energy Technology Data Exchange (ETDEWEB)

    Lampichler, K. [Medizinische Universitaet Wien, Universitaetsklinik fuer Radiologie und Nuklearmedizin, Allgemeines Krankenhaus, Wien (Austria)

    2017-01-15

    Despite a considerable number of antimicrobial agents and interdisciplinary treatment options, lower respiratory tract infections are still associated with high morbidity and mortality rates. Infections of the respiratory tract can lead to severe complications, such as empyema, lung abscesses and acute respiratory distress syndrome (ARDS). Besides intrapulmonary complications pneumonia can also impair other organs due to a systemic inflammatory response. Underlying cardiovascular diseases, such as chronic heart failure, arteriosclerosis and dysrhythmia can either deteriorate due to infections or be newly manifested as a result of pneumonia. Early diagnosis and therapy of these sometimes life-threatening complications are crucial and can have a severe impact on disease outcome. The most important imaging techniques include chest X-ray and computed tomography (CT) of the chest. Although a definite diagnosis is sometimes difficult or even impossible to establish using chest X-ray or CT, there are several findings indicative of intrapulmonary or extrapulmonary complications of pneumonia. Another useful and portable tool is thoracic ultrasound directly on the patient, which can be used to further define the underlying disease or as guidance during procedures. The chest X-ray is useful in initial diagnosis and follow-up. If complications or disease progression are suspected or the clinical course differs from the X-ray interpretation, a subsequent CT of the chest should be performed. (orig.) [German] Pneumonien sind trotz antimikrobieller Therapien und multidisziplinaerer Behandlungsstrategien unveraendert mit einer hohen Morbiditaets- und Mortalitaetsrate verbunden. Eine Infektion des Respirationstrakts kann zu Komplikationen wie Lungenempyem, -abszess und akutem Lungenversagen fuehren. Zusaetzlich kommt es neben den intrapulmonalen Komplikationen haeufig auch zur Beeintraechtigung anderer Organe. Kardiovaskulaere Grunderkrankungen wie Herzinsuffizienz, Arteriosklerose

  5. Einsatzmöglichkeiten eines saponinreichen Extrakts aus Quillaja saponaria Molina zur Formulierung und Stabilisierung von funktionellen Lebensmittelinhaltsstoffen

    OpenAIRE

    Tippel, Janine

    2017-01-01

    Emulgatoren werden in der Lebensmittelindustrie häufig zur Herstellung disperser Trägersysteme verwendet, welche eine Solubilisierung und Erhöhung der Stabilität von lipophilen Lebensmittelinhaltsstoffen ermöglichen. Für flüssige Lebensmittelsysteme können mizellare Systeme und Emulsionen eingesetzt werden. Eine Sprühtrocknung ermöglicht hier die Umwandlung flüssiger Formulierungen in feste Pulver, welche den Transport und die Einbringung in das Endprodukt vereinfachen. Zudem können durch Ver...

  6. Neue Elektrolyte zur Steigerung der Energiedichte einer nicht-wässrigen Vanadium-Acetylacetonat-Redox-Flow-Batterie

    OpenAIRE

    Herr, Tatjana

    2015-01-01

    Die Redox-Flow-Batterie ist eine vielversprechende Speicherungsmöglichkeit für stationäre Anwendungen. Bei dieser Batterie wird die Energie in einem flüssigen Elektrolyt gespeichert, wobei die Energiedichte von der Konzentration und dem Potentialfenster der gelösten redoxaktiven Substanz abhängt. Zur Steigerung der Energiedichte einer nicht-wässrigen Vanadium-Acetylacetonat-Redox-Flow-Batterie wurden organische Lösungsmittel, welche ein Potentialfenster bis zu 5 V aufweisen, und Lösungsmittel...

  7. School Shootings in Deutschland: Aktuelle Trends zur Prävention von schwerer, zielgerichteter Gewalt an deutschen Schulen

    OpenAIRE

    Bondü, Rebecca; Scheithauer, Herbert

    2009-01-01

    Die School Shootings in Winnenden und Ansbach im März und September 2009 haben die Notwendigkeit präventiver Ansätze zur Vermeidung weiterer Taten in Deutschland erneut verdeutlicht. Aufgrund der geringen Häuigkeit des Phänomens und der geringen Speziität der bekannten Risikofaktoren ist eine gezielte Vorhersage und Prävention jedoch schwierig. Dennoch werden zurzeit verschiedene Präventionsansätze diskutiert. Der vorliegende Artikel stellt diese vor und beleuchtet ihre Vor- und Nachteile. Da...

  8. Development of probabilistic methods for safety assessment of nuclear power plants; Weiterentwicklung probabilistischer Methoden zur Sicherheitsbeurteilung von Kernkraftwerken

    Energy Technology Data Exchange (ETDEWEB)

    Balfanz, H.P. [Technischer Ueberwachungs-Verein Norddeutschland e.V., Hamburg (Germany); Boehme, E. [Technischer Ueberwachungs-Verein Norddeutschland e.V., Hamburg (Germany); Fuhrmann, C. [Technischer Ueberwachungs-Verein Norddeutschland e.V., Hamburg (Germany); Musekamp, W. [Technischer Ueberwachungs-Verein Norddeutschland e.V., Hamburg (Germany); Neumann, L. [Technischer Ueberwachungs-Verein Norddeutschland e.V., Hamburg (Germany); Rumpf, J. [Technischer Ueberwachungs-Verein Norddeutschland e.V., Hamburg (Germany)

    1997-07-01

    We have worked out a comprehensive analytical concept for CCF event evaluation which is based on the international experience on the analysis of dependent failures and our own experiences from evaluating plant operation. The concept was discussed with utilities in Germany and from abroad. The CCF approach differs from other methods because it is strictly structured according to the CCF events and independent from any CCF model which is used in a PSA. Because of this attribute the concept is due to be used in the operational reviewing process by plant staff. We have an ongoing discussion with utilities on how to integrate this concept in practical plant site use. In addition we have recommended to adapt the main features of this concept in the PSA guideline. Plant management factors: Evaluations in different industries reveal a strong impact of organisational and management factors on the course of severe accidents. Because these factors cannot explicitly be measured they are not treated in a PSA today. Comprehensive development work is under way to gain an improved insight into the influence of these risk relevant factors. These activities are specifically aimed at root cause analyses of accidents, e.g. to uncover hidden organisational and management factors. NPP staff should be integrated in this analysis process. Living PSA application can play an important role in this development process. (orig./DG) [Deutsch] Auf der Grundlage des internationalen Erfahrungsstandes zur Analyse von abhaengigen Komponentenausfaellen und aufgrund unserer Erfahrungen aus der laufenden Auswertung des Kraftwerksbetriebes haben wir ein umfassendes Analysekonzept zur GVA-Datenerfassung erstellt und mit Kraftwerksbetreibern im In- und Ausland diskutiert. Dieses Konzept zeichnet sich im Unterschied zu anderen Ansaetzen durch die vom GVA-Modell unabhaengige ereignisbezogene GVA-Bewertung aus. Es ist daher von Kraftwerksbetreibern vorgesehen, dieses Konzept im Kraftwerksbetrieb bei der

  9. Solar-aided air conditioning through sorption. Final report. Phase 2; Solar unterstuetzte Klimatisierung ueber Sorption. Endbericht zur Phase 2

    Energy Technology Data Exchange (ETDEWEB)

    Laevemann, E; Kessling, W; Peltzer, M

    1996-09-24

    The present article reports on possibilities of using solar energy for cooling buildings. It contains the following chapters: Current state of research and development; room air conditioning; planning and results of the studies; theory; experimental studies on the sorption dehumidifier; development of exchange surfaces; development of solution distributors; cooling of exchange surfaces; construction of a sorption dehumidifier. (HW) [Deutsch] Die Arbeit berichtet ueber Moeglichkeiten der Anwendung von Solarenergie zur Kuehlung von Gebaeuden. Die Arbeit enthaelt folgende Kapitel: - Stand der Forschung und Entwicklung - Raumklimatisierung - Planung und Ergebnis der Untersuchungen - Theorie - Experimentelle Untersuchungen am Sorptionsentfeuchter - Entwicklung von Austauschflaechen - Entwicklung von Loesungsverteilern - Kuehlung von Austauschflaechen - Konstruktion eines Sorptionsentfeuchters. (HW)

  10. Churn-annular flow pattern transition in a vertical upward gas-liquid two-phase flow in various conduits

    International Nuclear Information System (INIS)

    Takenaka, Nobuyuki; Ueda, Tadanobu; Asano, Hitoshi

    2008-01-01

    Void fraction was measured by neutron radiography for a vertical upward gas-water two-phase flow in a concentric annular tube with and with out a spacer, 4x4 rod bundle with and without a spacer and a tight rod bundle with and without a wrapping wire for various gas and liquid flow rates. The flow patterns of these two-phase flows were determined by the Mishima-Ishii flow pattern map and void fraction was calculated by the Ishii's drift flux model. The predicted values were compared with the experimental results. The void fraction was well predicted by the Mishima-Ishii flow pattern map and the Ishii's drift flux model except the annular flow region with void fraction lower than 0.8 for conduits with small equivalent diameter. A new churn-annular flow pattern transition condition of the void fraction equal to 0.8 was added. The void fraction for the present experimental condition was successful predicted with the new transition model. (author)

  11. Surgical Anatomy and Microvascular Surgical Technique Relevant to Experimental Renal Transplant in Rat Employing Aortic and Inferior Venacaval Conduits.

    Science.gov (United States)

    Shrestha, Badri Man; Haylor, John

    2017-11-15

    Rat models of renal transplant are used to investigate immunologic processes and responses to therapeutic agents before their translation into routine clinical practice. In this study, we have described details of rat surgical anatomy and our experiences with the microvascular surgical technique relevant to renal transplant by employing donor inferior vena cava and aortic conduits. For this study, 175 rats (151 Lewis and 24 Fisher) were used to establish the Fisher-Lewis rat model of chronic allograft injury at our institution. Anatomic and technical details were recorded during the period of training and establishment of the model. A final group of 12 transplanted rats were studied for an average duration of 51 weeks for the Lewis-to-Lewis isografts (5 rats) and 42 weeks for the Fisher-to-Lewis allografts (7 rats). Functional measurements and histology confirmed the diagnosis of chronic allograft injury. Mastering the anatomic details and microvascular surgical techniques can lead to the successful establishment of an experimental renal transplant model.

  12. Minimizing coupling loss by selection of twist pitch lengths in multi-stage cable-in-conduit conductors

    International Nuclear Information System (INIS)

    Rolando, G; Nijhuis, A; Devred, A

    2014-01-01

    The numerical code JackPot-ACDC (van Lanen et al 2010 Cryogenics 50 139–48, van Lanen et al 2011 IEEE Trans. Appl. Supercond. 21 1926–9, van Lanen et al 2012 Supercond. Sci. Technol. 25 025012) allows fast parametric studies of the electro-magnetic performance of cable-in-conduit conductors (CICCs). In this paper the code is applied to the analysis of the relation between twist pitch length sequence and coupling loss in multi-stage ITER-type CICCs. The code shows that in the analysed conductors the coupling loss is at its minimum when the twist pitches of the successive cabling stages have a length ratio close to one. It is also predicted that by careful selection of the stage-to-stage twist pitch ratio, CICCs cabled according to long twist schemes in the initial stages can achieve lower coupling loss than conductors with shorter pitches. The result is validated by AC loss measurements performed on prototype conductors for the ITER Central Solenoid featuring different twist pitch sequences. (paper)

  13. Effect of current imbalance on stability of a cable-in-conduit conductor consisting of chrome-plated strands

    International Nuclear Information System (INIS)

    Koizumi, Norikiyo; Takahashi, Yoshikazu; Nishi, Masataka; Isono, Takaaki; Tsuji, Hiroshi; Ono, Michitaka; Hamajima, Takataro; Fujioka, Tsutomu.

    1997-02-01

    The effect of an unbalanced current distribution in a conductor consisting of chrome plated strands on stability was investigated using a cable-in-conduit conductor (CICC) consisting of 27 NbTi chrome-plated strands. In addition, the quench behavior when a non-uniform current distribution was produced in the conductor was studied from the experimental results. Moreover, impedance of the chrome-plated strands was measured using the sample conductor. The results show that the stability is determined by the largest strand current when it is sufficiently large otherwise by the transport current when it is not high enough. It was found that it took a long time to make the conductor quench from the onset of the normal transition of the strand carrying the large current. This is explained by the good diffusivity of the coolant temperature in the conductor's cross section. Since the ramp-rate limitation cannot probably take place if the coolant temperature is diffused well in the conductor's cross section, it is expected the ramp-rate limitation can be prevented using this effect. It is also shown that the chrome-plated strands come into contact with one another with uniform transverse conductance on the order of 10 3 S/m. (author)

  14. Performance of cable-in-conduit conductors in ITER [International Thermonuclear Experimental Reactor] toroidal field coils with varying heat loads

    International Nuclear Information System (INIS)

    Kerns, J.A.; Wong, R.L.

    1989-01-01

    The toroidal field (TF) coils in the International Thermonuclear Experimental Reactor (ITER) will operate with varying heat loads generated by ac losses and nuclear heating. The total heat load is estimated to be 2 kW per TF coil under normal operation and can be higher for different operating scenarios. Ac losses are caused by ramping the poloidal field (PF) for plasma initiation, burn, and shutdown; nuclear heating results from neutrons that penetrate into the coil past the shield. Present methods to reduce or eliminate these losses lead to larger and more expensive machines, which are unacceptable with today's budget constraints. A suitable solution is to design superconductors that operate with high heat loads. The cable-in-conduit conductor (CICC) can operate with high heat loads. One CICC design is analyzed for its thermal performance using two computer codes developed at LLNL. One code calculates the steady state flow conditions along the flow path, while the other calculates the transient conditions in the flow. We have used these codes to analyze the superconductor performance during the burn phase of the ITER plasma. The results of these analyses give insight to the choice of flow rate on superconductor performance. 4 refs., 5 figs

  15. Computational modeling of lava domes using particle dynamics to investigate the effect of conduit flow mechanics on flow patterns

    Science.gov (United States)

    Husain, Taha Murtuza

    Large (1--4 x 106 m3) to major (> 4 x 106 m3) dome collapses for andesitic lava domes such as Soufriere Hills Volcano, Montserrat are observed for elevated magma discharge rates (6--13 m3/s). The gas rich magma pulses lead to pressure build up in the lava dome that result in structural failure of the over steepened canyon-like walls which may lead to rockfall or pyroclastic flow. This indicates that dome collapse intimately related to magma extrusion rate. Variation in magma extrusion rate for open-system magma chambers is observed to follow alternating periods of high and low activity. Periodic behavior of magma exhibits a rich diversity in the nature of its eruptive history due to variation in magma chamber size, total crystal content, linear crystal growth rate and magma replenishment rate. Distinguished patterns of growth were observed at different magma flow rates ranging from endogenous to exogenous dome growth for magma with varying strengths. Determining the key parameters that control the transition in flow pattern of the magma during its lava dome building eruption is the main focus. This dissertation examines the mechanical effects on the morphology of the evolving lava dome on the extrusion of magma from a central vent using a 2D particle dynamics model. The particle dynamics model is coupled with a conduit flow model that incorporates the kinetics of crystallization and rheological stiffening to investigate important mechanisms during lava dome building eruptions. Chapter I of this dissertation explores lava dome growth and failure mechanics using a two-dimensional particle-dynamics model. The model follows the evolution of fractured lava, with solidification driven by degassing induced crystallization of magma. The particle-dynamics model emulates the natural development of dome growth and rearrangement of the lava dome which is difficult in mesh-based analyses due to mesh entanglement effects. The deformable talus evolves naturally as a frictional

  16. Hawaiian fissure fountains: Quantifying vent and shallow conduit geometry, episode 1 of the 1969-1974 Mauna Ulu eruption: Chapter 17

    Science.gov (United States)

    Parcheta, Carolyn; Fagents, Sarah; Swanson, Donald A.; Houghton, Bruce F.; Ericksen, Todd; Carey, Rebecca; Cayol, Valérie; Poland, Michael P.; Weis, Dominique

    2015-01-01

    Geometries of shallow magmatic pathways feeding volcanic eruptions are poorly constrained, yet many key interpretations about eruption dynamics depend on knowledge of these geometries. Direct quantification is difficult because vents typically become blocked with lava at the end of eruptions. Indirect geophysical techniques have shed light on some volcanic conduit geometries, but the scales are too coarse to resolve narrow fissures (widths typically 1 m). Kīlauea's Mauna Ulu eruption, which started with 30 m. Direct measurements at the ground surface were augmented by tripod-mounted lidar measurements to quantify the shallow conduit geometry for three vents at a resolution eruptive behavior, especially if incorporated into computer models.

  17. Hypoglossal-facial nerve reconstruction using a Y-tube-conduit reduces aberrant synkinetic movements of the orbicularis oculi and vibrissal muscles in rats.

    Science.gov (United States)

    Kaya, Yasemin; Ozsoy, Umut; Turhan, Murat; Angelov, Doychin N; Sarikcioglu, Levent

    2014-01-01

    The facial nerve is the most frequently damaged nerve in head and neck trauma. Patients undergoing facial nerve reconstruction often complain about disturbing abnormal synkinetic movements of the facial muscles (mass movements, synkinesis) which are thought to result from misguided collateral branching of regenerating motor axons and reinnervation of inappropriate muscles. Here, we examined whether use of an aorta Y-tube conduit during reconstructive surgery after facial nerve injury reduces synkinesis of orbicularis oris (blink reflex) and vibrissal (whisking) musculature. The abdominal aorta plus its bifurcation was harvested (N = 12) for Y-tube conduits. Animal groups comprised intact animals (Group 1), those receiving hypoglossal-facial nerve end-to-end coaptation alone (HFA; Group 2), and those receiving hypoglossal-facial nerve reconstruction using a Y-tube (HFA-Y-tube, Group 3). Videotape motion analysis at 4 months showed that HFA-Y-tube group showed a reduced synkinesis of eyelid and whisker movements compared to HFA alone.

  18. Norwood with right ventricle-to-pulmonary artery conduit is more effective than Norwood with Blalock-Taussig shunt for hypoplastic left heart syndrome: mathematic modeling of hemodynamics.

    Science.gov (United States)

    Mroczek, Tomasz; Małota, Zbigniew; Wójcik, Elżbieta; Nawrat, Zbigniew; Skalski, Janusz

    2011-12-01

    The introduction of right ventricle to pulmonary artery (RV-PA) conduit in the Norwood procedure for hypoplastic left heart syndrome resulted in a higher survival rate in many centers. A higher diastolic aortic pressure and a higher mean coronary perfusion pressure were suggested as the hemodynamic advantage of this source of pulmonary blood flow. The main objective of this study was the comparison of two models of Norwood physiology with different types of pulmonary blood flow sources and their hemodynamics. Based on anatomic details obtained from echocardiographic assessment and angiographic studies, two three-dimensional computer models of post-Norwood physiology were developed. The finite-element method was applied for computational hemodynamic simulations. Norwood physiology with RV-PA 5-mm conduit and Blalock-Taussig shunt (BTS) 3.5-mm shunt were compared. Right ventricle work, wall stress, flow velocity, shear rate stress, energy loss and turbulence eddy dissipation were analyzed in both models. The total work of the right ventricle after Norwood procedure with the 5-mm RV-PA conduit was lower in comparison to the 3.5-mm BTS while establishing an identical systemic blood flow. The Qp/Qs ratio was higher in the BTS group. Hemodynamic performance after Norwood with the RV-PA conduit is more effective than after Norwood with BTS. Computer simulations of complicated hemodynamics after the Norwood procedure could be helpful in establishing optimal post-Norwood physiology. Copyright © 2011 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.

  19. Enhancement of Median Nerve Regeneration by Mesenchymal Stem Cells Engraftment in an Absorbable Conduit: Improvement of Peripheral Nerve Morphology with Enlargement of Somatosensory Cortical Representation.

    Directory of Open Access Journals (Sweden)

    Julia Teixeira Oliveira

    2014-10-01

    Full Text Available We studied the morphology and the cortical representation of the median nerve (MN, 10 weeks after a transection immediately followed by treatment with tubulization using a polycaprolactone (PCL conduit with or without bone marrow-derived mesenchymal stem cell (MSC transplant. In order to characterize the cutaneous representation of MN inputs in primary somatosensory cortex (S1, electrophysiological cortical mapping of the somatosensory representation of the forepaw and adjacent body parts was performed after acute lesion of all brachial plexus nerves, except for the MN. This was performed in ten adult male Wistar rats randomly assigned in 3 groups: MN Intact (n=4, PCL-Only (n=3 and PCL+MSC (n=3. Ten weeks before mapping procedures in animals from PCL-Only and PCL+MSC groups, animal were subjected to MN transection with removal of a 4-mm-long segment, immediately followed by suturing a PCL conduit to the nerve stumps with (PCL+MSC group or without (PCL-Only group injection of MSC into the conduit. After mapping the representation of the MN in S1, animals had a segment of the regenerated nerve processed for light and transmission electron microscopy. For histomorphometric analysis of the nerve segment, sample size was increased to 5 animals per experimental group. The PCL+MSC group presented a higher number of myelinated fibers and a larger cortical representation of MN inputs in S1 (3,383±390 fibers; 2.3 mm2, respectively than the PCL-Only group (2,226±575 fibers; 1.6 mm2. In conclusion, MSC-based therapy associated with PCL conduits can improve MN regeneration. This treatment seems to rescue the nerve representation in S1, thus minimizing the stabilization of new representations of adjacent body parts in regions previously responsive to the MN.

  20. Patientenakzeptanz und Verträglichkeit von Risedronat zur Osteoporosetherapie - Ergebnisse einer Phase IV-Studie

    Directory of Open Access Journals (Sweden)

    Pusch HH

    2001-01-01

    Full Text Available Anwendungsbeobachtungen (Phase IV-Studien haben nach den erfolgreich absolvierten klinischen Prüfungen (Phase III den Zweck, die Verträglichkeit, Sicherheit, Compliance und Akzeptanz eines Präparates in der täglichen praktischen Medizin zu erfassen und auszuwerten. Eine AWB ist prospektiv aufgebaut. Die 1121 in dieser Studie erfaßten Patienten stellen ein solides Fundament für die statistische Aufarbeitung der erhobenen Daten dar. Die Ergebnisse zu den Themen Patientendaten, Diagnosestellung, Risikofaktoren, Frakturen und Mobilität zeigen deutlich, daß hier ein spezielles Patientengut vorliegt: Der Patient mit Osteoporose mit den typischen alterskorrelierten Begleiterkrankungen. Die Osteoporose verläuft, so lange keine Frakturen eintreten, praktisch schmerzfrei - ein Grund, warum diese Erkrankung so oft und so lange ignoriert wird. Begleitende Beschwerden gehen nach der derzeitigen Lehrmeinung stets auf degenerative oder entzündlich-rheumatische Prozesse am Bewegungsapparat zurück. Aus diesem Blickwinkel bieten die Ergebnisse dieser Studie eine Überraschung: Die im Bereich der Wirbelsäule beobachtete und statistisch hochsignifikante Schmerzlinderung. Sie läßt sich jedoch mit der Hemmung des Knochenabbaues durch Risedronat alleine nicht befriedigend erklären. Möglicherweise liegen hier andere, bisher unbekannte pharmakologische Effekte dieser Substanz vor. Zusätzliche Hinweise ergeben sich daraus, daß beim Mb. Paget ähnliche Wirkungen auf die Begleitschmerzen bei Bisphosphonatbehandlung berichtet wurden. Die analgetische Wirkung von Calcitonin ist bekannt, sie beruht auf einer zentralnervösen Wirkung, ebenso wie auf der Hemmung der Freisetzung von freien Kalzium-Ionen, die als Schmerzmediator angesehen werden, aus dem Knochen. Vielleicht liegen hier vergleichbare Effekte vor, die in den Phase II und III Studien nicht zutage treten konnten. Diese überraschenden Ergebnisse sollten Anlaß für weitere Forschungen sein. Die

  1. Sun - the energy of the 21. century. Strategies for cost reduction in solar cells; Sonne - Die Energie des 21. Jahrhunderts. Strategien zur Kostensenkung von Solarzellen

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-10-01

    The document comprises 2 sections with 20 contributions each. Subjects: 1. Solar energy, power for the 21st century,; 2. Strategies for cost reduction in solar cells. [German] Das Document behandelt in zwei Bloeken und mit 20 Betraegen die folgenden Themen: 1. Die ''Sonne'' als die Energie des 21. Jahrhunderts und 2. Strategien zur Kostensenkung von Solarzellen. (orig.)

  2. 14th colloquium and training course on sewage management: Treatment, discharge, monitoring. Proceedings; 14. Kolloquium und Fortbildungskurs zur Abwasserwirtschaft: Abwasserbehandlung, Abwasserableitung, Ueberwachung. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Gulyas, H.; Otterpohl, R. (eds.)

    2002-07-01

    Subjects of the conference were waste water treatment, handling of waste water constituents like sulphur, AOX, TBT, denitrification processes, waste water analysis and toxicity tests, sewage sludge composting. [German] Im Tagungsband sind die Beitraege zur Fortbildungstagung zusammengestellt. Die Themen waren Aspekte der Abwasserbehandlung, Handhabung spezieller Abwasserinhaltsstoffe wie Schwefel, AOX, TBT, Denitrifikationsverfahren, Abwasseranalytik und Toxizitaetstests, Klaerschlammvererdung. (uke)

  3. Studies on the hazard potential of noble metal emissions from catalytic converters; Untersuchungen zur Frage des Gefaehrdungspotentials von katalysatorbuertigen Edelmetallemissionen (VPT 05)

    Energy Technology Data Exchange (ETDEWEB)

    Artelt, S [Fraunhofer-Institut fuer Toxikologie und Aerosolforschung, Hannover (Germany)

    1998-12-31

    Plants were exposed to engine exhaust fumes from engine test stands in order to estimate the probable level of platinum deposition near roads. [Deutsch] Zur Abschaetzung der zu erwarteten Platindeposition in der Naehe von Strassen wurden Pflanzen mit Motorabgasen, die aus Motorstandexperimenten gewonnen wurden, beaufschlagt. (orig.)

  4. Ein Beitrag zur aquatischen Käferfauna von Walcheren, Niederlande (Insecta, Coleoptera) unter besonderer Berücksichtigung von Halophilen und Halobionten Arten

    NARCIS (Netherlands)

    Burmeister, E.-G.

    1982-01-01

    EINLEITUNG In den Jahren 1975, 1977 und 1978 konnten in den Sommermonaten zahlreiche Gewässer der Halbinsel Walcheren auf ihre aquatische Käferfauna hin untersucht werden. Walcheren, ehemals eine Insel in der Scheidemündung, gehört zur Provinz Zeeland und ist heute durch die Polderlandschaft

  5. Studies on the hazard potential of noble metal emissions from catalytic converters; Untersuchungen zur Frage des Gefaehrdungspotentials von katalysatorbuertigen Edelmetallemissionen (VPT 05)

    Energy Technology Data Exchange (ETDEWEB)

    Artelt, S. [Fraunhofer-Institut fuer Toxikologie und Aerosolforschung, Hannover (Germany)

    1997-12-31

    Plants were exposed to engine exhaust fumes from engine test stands in order to estimate the probable level of platinum deposition near roads. [Deutsch] Zur Abschaetzung der zu erwarteten Platindeposition in der Naehe von Strassen wurden Pflanzen mit Motorabgasen, die aus Motorstandexperimenten gewonnen wurden, beaufschlagt. (orig.)

  6. Re-Imagining "Bildung Zur Humanität": How I Developed the Dialogos Approach to Practical Philosophy through Action Inquiry Research

    Science.gov (United States)

    Helskog, Guro Hansen

    2015-01-01

    This paper presents an account of how I developed the Dialogos approach to practical philosophy through action inquiry research. The process of development is understood as a contribution to the reconstruction of the notion "Bildung zur Humanität" as an ideal in education. Core perspectives, traditions and purposes involved in the action…

  7. Zur nachhaltig ausgerichteten Dekonstruktion des wirtschafts-didaktischen Diskurses über ökonomische Kategoriensysteme

    Directory of Open Access Journals (Sweden)

    Frank Skrzipietz

    2009-08-01

    Full Text Available Der Beitrag reflektiert am Beispiel wirtschaftskategorialer Systeme den Status quo bezogen auf die Implementierung des normativen Nachhaltigkeitsgedankens in curriculare Strukturen und fachdidaktische Konzepte ökonomischer Bildung. Dazu wird die These entwickelt, dass eine einseitig auf neoklassische Kategorien ausgerichtete Wirtschaftsdidaktik eine nur unzureichend fundierte Plattform darstellt, um wirtschafts- und nachhaltigkeitsbezogene Probleme angemessen diskutieren, bearbeiteten und lösen zu können. Es wird gezeigt, dass die im Modus von wirtschaftkategorialen Struktureinsichten angebotene Objektseite ökonomischer Bildung zu eng angelehnt ist an die Modelle der neoklassisch geprägten Wissenschaftssystematik. Es bedarf hier nachdrücklich einer Erweiterung der an den Logiken neoklassischer Modellierungen orientierten stoffkategorialen Systeme um soziale und ökologische Faktoren bzw. um Kategorien aus dem Nachhaltigkeitsdiskurs, wie z.B. Vernetzung, Gerechtigkeit, Globalität, Zukunft, Kommunikation und Partizipation. Als Grundlage für die Entwicklung wirtschaftskategorialer Systeme und zur fachwissenschaftlichen Fundierung curricularer Konstruktionen ökonomischer Bildung im Sinne der Nachhaltigkeitsidee wird ein interdisziplinärer Zugang sowie ein Rekurs auf alternative ökonomische Referenztheorien bzw. -modelle empfohlen.The article reflects on the status quo with regard to the implementation of the normative sustainability-idea in curricular structures and didactical concepts of economic education using the example of economic-categorical systems. Accordingly, it is not appropriate to discuss and treat economical and sustainable problems through an economic didactic which is based upon neoclassical categories in biased way but to demonstrate that the economical categories intensively refer upon the models of neoclassical economy. Therefore an extension of neoclassical models towards social and ecological factors and categories

  8. Zur Konzeption kritischer Stadtforschung. Ansätze jenseits einer Eigenlogik der Städte

    Directory of Open Access Journals (Sweden)

    Jan Kemper

    2013-06-01

    Full Text Available Kritische Stadtforschung dient in Gestalt der „kritischen Stadtsoziologie“ gegenwärtig als Negativfolie für jene Stadtforschungsperspektive, die mit dem Postulat einer „Eigenlogik der Städte“ (EdS antritt. Eine (Selbst-Verständigung über konzeptionelle Grundlagen und forschungsstrategische Absichten einer kritischen Stadtforschung dagegen gibt es kaum. Ausgehend von dieser Beobachtung ist es das Ziel dieses Beitrags, zu einer Konturierung kritischer Stadtforschung beizutragen. Dafür skizzieren wir zunächst Eckpunkte der EdS-Perspektive. Anschließend wird ein Blick zurück auf den Klassiker Die Lage der arbeitenden Klasse in England (1845 von Friedrich Engels geworfen. Daran verdeutlichen wir drei Schritte in der Etablierung einer kritischen Haltung in der Stadtforschung: die Berücksichtigung der historisch-sozialen Voraussetzungen für gegenwärtige Stadtentwicklungsprozesse, die Analyse der städtischen Raum- und Sozialverhältnisse als krisen- und konfliktvermittelte und deshalb als dynamische Verhältnisse sowie die Konzeptionierung dieser Verhältnisse als veränderbar. An drei wiederkehrenden Diskussionsfeldern sozialwissenschaftlicher Stadtforschung schließlich verfolgen wir, wie einerseits die EdS-Perspektive sich dieser Themen annimmt und wie andererseits eine kritische Haltung im Umgang mit diesen Themen eingenommen werden kann. Für eine kritische Stadtforschung schlagen wir vor, (a „Stadt“ nicht als dauerhaft definiert und nicht als erklärend für sozialräumliche Verhältnisse zu begreifen, (b auch Städte als Räume zu konzipieren, die sich im gegenseitigen Wechselverhältnis mit Gesellschaft konstituieren, (c mit einem Konzept von Differenz, das Unterschiede sozial erklärt, zu arbeiten, wenn Städte als einzigartig erlebte Orte analysiert werden sollen.

  9. LINGUA TERTII IMPERII. VICTOR KLEMPERERS DIARISTISCHE ERÖRTERUNGEN ZUR ANTISEMITISCHEN HASSREDE

    Directory of Open Access Journals (Sweden)

    Arvi SEPP

    2010-11-01

    Full Text Available Victor Klemperers Tagebücher Ich will Zeugnis ablegen bis zum letzten: Tagebücher 1933-1945 haben nach ihrem Erscheinen Mitte der 1990er Jahre ein starkes Echo gefunden und gehören inzwischen zum Kanon der Tagebuchliteratur. Das zweibändige, während der nationalsozialistischen Diktatur entstandene Tagebuchwerk beschreibt die Lebenswelt eines deutsch-jüdischen Verfolgten im Dritten Reich. Der Antisemitismus zwang den Philologen zu einer Auseinandersetzung mit dem Relevanzverlust seiner Assimilationsbemühungen und seiner Kennzeichnung als Jude. Eine rekurrente Kompensationstaktik gegen seine erzwungene Randstellung besteht in der sprachkritischen Demontierung des Rassendenkens, um die Ungültigkeit des Antisemitismus nachzuweisen. Die Beobachtungen zur Lingua Tertii Imperii, die er in den Tagebuchblättern aufschrieb, wurden immer mehr zu seinem eigentlichen Werk. Das Tagebuch ist vor diesem Hintergrund in weiten Teilen zum Arbeitsjournal für die Sprachund Kulturanalysen Klemperers geworden. Der Interdependenz von Sprachkritik und Mentalitätsgeschichte in Klemperers Analyse der Sprache des Dritten Reiches gilt im vorliegenden Aufsatz das Hauptinteresse. Im ersten Teil wird der Frage nachgegangen, auf welche Art und Weise Victor Klemperer in seinen Notizen die Beziehung zwischen Sprache, Ideologie und Mentalität verstand. Im zweiten Teil wird unter Rückgriff auf Judith Butler und Louis Althusser in den Vordergrund gerückt, wie Victor Klemperer im Tagebuch vor Augen führt, dass das verletzende Sprechen gegen Juden im Nationalsozialismus eine subjektkonstituierende Wirkung hatte. Im letzten Teil des Aufsatzes gilt das Hauptaugenmerk der vom Tagebuchautor festgestellten diskursiven Einverleibung antisemitischer Rhetorik durch die verfolgte jüdische Bevölkerung.

  10. Tradable permits. The stony path to a market economy; Umweltzertifikate. Der steinige Weg zur Marktwirtschaft

    Energy Technology Data Exchange (ETDEWEB)

    Bonus, H. [ed.

    1998-12-31

    Thirty years ago, Thomas D. Crocker and John H. Dales came up with the idea of tradable permits for making environmental protection both economically and ecologically efficient. Since then, a heated and controversial discussion has been going on. Tradable permits were considered as unrealistic, contra-competitive, incompatible with political structures, and even as an attempt to treat Mother Nature as a whore. As a result, Germany still operates by the command-and-control principle, and there are no significant examples of emission trading. The first part of this publication reviews the theoretical discussion and practical experiemce so far, while the second part discusses the requirements that must be met by tradable permit systmes in order to make them practicable. [Deutsch] Dreissig Jahre Diskussion ueber Zertifikate zeigen, dass der Weg zu einer marktwirtschaftlich ausgerichteten Umweltpolitik steinig ist. Die bahnbrechende Idee von Thomas D. Crocker und John H. Dales, mit Zertifikaten Umweltschutz sowohl oekonomisch effizient wie auch oekologisch treffsicher zu realisieren, wurde in der Vergangenheit immer wieder von Zweifeln an der Praktikabilitaet einer solchen Loesung ueberlagert. So wurde der Handel mit Zertifikaten als unrealisierbar angesehen, wettbewerbs- und strukturpolitische Einwaende wurden angefuehrt, und man empfand die Vergabe von Rechten zur Umweltnutzung sogar als Prostitution von Mutter Natur. Als Folge hat Deutschland bis heute kein signifikantes Umsetzungsbeispiel vorzuweisen; das Ordnungsrecht beherrscht nach wie vor die Szene. Der erste Teil des Bandes beleuchtet zunaechst den Stand der theoretischen Diskussion und die bisher gemachten Erfahrungen mit Zertifikaten. Der zweite Teil ist den Anforderungen gewidmet, denen Zertifikatesysteme gerecht werden muessen, um Eingang in die Praxis zu finden. (orig.)

  11. Environmental compatibility of chemicals for sewage treatment; Umweltvertraeglichkeit von Chemikalien zur Abwasserbehandlung

    Energy Technology Data Exchange (ETDEWEB)

    Schumann, H.; Obst, K.; Friedrich, C.; Pattard, M.; Pluta, H.J.; Hahn, J.

    1997-05-30

    Due to the use of chemicals for waste water treatment the treated waste water and the effluents are polluted by the accompanying substance matrix of the chemicals. Furthermore, because of overstoichiometric dosage or additives also a not reacting part of toxic substances gets into the treated waste water and effluents. Therefore it is necessary to prevent that through waste water treatment further environmentally incompatible substances get into the waters. Within the framework of a research project promoted by the Federal Ministry of the Environment, Nature Conservation and Reactor Safety proposals were made for guide values and respectively limit values for coagulant and flocculant salts, lime products, neutralising agents, technical hydrochloric acid, technical sulphuric acid, polyacrylamides and organic sulphuric compounds. In contrast to most of the anorganic chemicals for waste water treatment, which show only a relatively low increase of heavy metal concentrations caused by the accompanying substance matrix, organic chemicals for sewage treatment are partly considered to be problematic substances because of an adverse combination of characteristics. (orig.) [Deutsch] Durch den Einsatz von Chemikalien zur Behandlung von Abwaessern gelangen - Verunreinigungen durch die Nebenstoff-Matrix der eingesetzten Behandlungschemikalien in das behandelte Abwasser und in die Gewaesser und - durch ueberstoechiometrische Dosierung oder Additive tritt der nicht reagierende Teil toxischer Substanzen ebenfalls im behandelten Abwasserablauf und im Gewaesser auf. Vor diesem Hintergrund gilt es zu verhindern, dass durch Massnahmen der Abwasserbehandlung zusaetzlich umweltunvertraegliche Stoffe in die Gewaesser eingetragen werden. Im Rahmen eines vom Bundesministerium fuer Umwelt, Naturschutz und Reaktorsicherheit gefoerderten Forschungsvorhabens wurden Vorschlaege fuer Richtwerte bzw. Anforderungen an Faellungs- und Flockungssalze, Kalkprodukte, Natronlauge, Soda, Salzsaeure

  12. Recommendations on procedures for renal function imaging; Anleitung zur Durchfuehrung der Nierenfunktionsszintigraphie

    Energy Technology Data Exchange (ETDEWEB)

    Klaeser, B.; Eberl, A.; Bubeck, B. [Klinik fuer Nuklearmedizin, Kantonsspital St. Gallen (Switzerland)

    2003-09-01

    Renal function diagnostics in nuclear medicine is nowadays performed primarily as scintigraphic study using {sup 99m}Tc-MAG3, in many cases accompanied by quantitative clearance measurement. The present recommendations are based on the technical protocols of the Clinic of Nuclear Medicine at the Kantonsspital St. Gallen and do not claim to be complete or the Gold Standard. The procedures described are not subject to discussion, but the authors attempt to give practical guidelines as orientation for users in their daily routine. Focal points are preparation and performance of the diuretic renography with furosemide to evaluate urinary outflow obstructions and scintigraphic studies under captopril for detection of renovascular hypertension. Further subjects are the quantitative clearance measurement according to the single-sample method and, of course, the calculation of the split clearance. All of these subjects are described mainly under practical aspects, looking in particular at frequent pitfalls or wrong interpretations, but also taking into account quality assurance and data analysis. Selected cases are presented to document the importance of renal function imaging in practice. (orig.) [German] Die nuklearmedizinische Nierenfunktionsdiagnostik wird heute vorrangig als Szintigraphie mit {sup 99m}Tc-MAG3 betrieben, haeufig mit begleitender quantitativer Clearancemessung. Die vorliegende Anleitung basiert auf den Untersuchungsprotokollen der Klinik fuer Nuklearmedizin des Kantonsspitals St. Gallen und erhebt weder Anspruch auf Vollstaendigkeit noch darauf, als Goldstandard zu gelten. Die beschriebenen Vorgehensweisen werden nicht diskutiert, sondern die Autoren versuchen, pragmatische Leitlinien zu vermitteln, an denen sich der Anwender in der taeglichen Routine orientieren kann. Schwerpunkte bilden die Vorbereitung und Durchfuehrung der so genannten Lasix-Szintigraphie zur Beurteilung der renalen Abflussverhaeltnisse und die Captopril-Szintigraphie bei der Frage

  13. Analyses of functional brain connectivity; Untersuchungen zur funktionellen Konnektivitaet des Gehirns

    Energy Technology Data Exchange (ETDEWEB)

    Stephan, K.E.

    2003-03-01

    This dissertation includes two independent studies that investigate two complementary aspects of functional connectivity in the Macaque and the human brain. In the first study, a computational meta-analysis of published electrophysiological data on context-independent functional brain connectivity was conducted by means of three independent methods. The second study investigated the effects of the atypical antipsychotic substance olanzapine on the functional connectivity of the cerebellum during a simple motor task (self-paced finger tapping). Six schizophrenic patients and six control subjects matched for age and sex were investigated by functional magnetic resonance imaging (fMRI) twice. This study provided the first experimental data on the effects of atypical antipsychotic agents on functional brain connectivity and demonstrated pronounced olanzapine-dependent changes of functional couplings between cerebellum, thalamus, and prefrontal cortex. (orig.) [German] In der hier vorgelegten Arbeit werden zwei komplementaere Aspekte der funktionellen Konnektivitaet - im Gehirn des Makaken und Menschen anhand zweier separater Studien untersucht. In der ersten Studie wurde mittels dreier unabhaengiger Methoden eine Metaanalyse publizierter elektrophysiologischer Daten zur kontextunabhaengigen funktionellen Konnektivitaet des Makakenkortex durchgefuehrt. Diese Studie erbrachte damit zum ersten Mal den Nachweis einer funktionellen Small World-Netzwerkstruktur des Primatenkortex. In der zweiten Studie wurde der Effekt des atypischen Neuroleptikums Olanzapin auf die funktionelle Konnektivitaet des Zerebellums im Kontext einer einfachen motorischen Aufgabe (selbstgesteuertes Fingertrapping) untersucht. Sechs schizophrene Patienten, die Neuroleptika-naiv bzw. -entwoehnt waren, sowie sechs alters- und geschlechtsentprechende Kontrollprobanden wurden im Abstand von jeweils drei Wochen mit funktioneller Magnetresonanztomografie (fMRT) untersucht. Diese Studie lieferte die ersten

  14. Large-area irradiated low-level laser effect in a biodegradable nerve guide conduit on neural regeneration of peripheral nerve injury in rats.

    Science.gov (United States)

    Shen, Chiung-Chyi; Yang, Yi-Chin; Liu, Bai-Shuan

    2011-08-01

    This study used a biodegradable composite containing genipin-cross-linked gelatin annexed with β-tricalcium phosphate ceramic particles (genipin-gelatin-tricalcium phosphate, GGT), developed in a previous study, as a nerve guide conduit. The aim of this study was to analyse the influence of a large-area irradiated aluminium-gallium-indium phosphide (AlGaInP) diode laser (660 nm) on the neural regeneration of the transected sciatic nerve after bridging the GGT nerve guide conduit in rats. The animals were divided into two groups: group 1 comprised sham-irradiated controls and group 2 rats underwent low-level laser (LLL) therapy. A compact multi-cluster laser system with 20 AlGaInP laser diodes (output power, 50mW) was applied transcutaneously to the injured peripheral nerve immediately after closing the wound, which was repeated daily for 5 min for 21 consecutive days. Eight weeks after implantation, walking track analysis showed a significantly higher sciatic function index (SFI) score (Pguide conduit in rats. Copyright © 2011 Elsevier Ltd. All rights reserved.

  15. Distilling allometric and environmental information from time series of conduit size: the standardization issue and its relationship to tree hydraulic architecture.

    Science.gov (United States)

    Carrer, Marco; von Arx, Georg; Castagneri, Daniele; Petit, Giai

    2015-01-01

    Trees are among the best natural archives of past environmental information. Xylem anatomy preserves information related to tree allometry and ecophysiological performance, which is not available from the more customary ring-width or wood-density proxy parameters. Recent technological advances make tree-ring anatomy very attractive because time frames of many centuries can now be covered. This calls for the proper treatment of time series of xylem anatomical attributes. In this article, we synthesize current knowledge on the biophysical and physiological mechanisms influencing the short- to long-term variation in the most widely used wood-anatomical feature, namely conduit size. We also clarify the strong mechanistic link between conduit-lumen size, tree hydraulic architecture and height growth. Among the key consequences of these biophysical constraints is the pervasive, increasing trend of conduit size during ontogeny. Such knowledge is required to process time series of anatomical parameters correctly in order to obtain the information of interest. An appropriate standardization procedure is fundamental when analysing long tree-ring-related chronologies. When dealing with wood-anatomical parameters, this is even more critical. Only an interdisciplinary approach involving ecophysiology, wood anatomy and dendrochronology will help to distill the valuable information about tree height growth and past environmental variability correctly. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  16. Electromagnetic and ultrasonic techniques to evaluate stress states of components; Elektromagnetische und Ultraschallverfahren zur Spannungsanalyse an Bauteilen

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, E.; Kern, R.; Theiner, W.A. [Fraunhofer Inst. fuer Zerstoerungsfreie Pruefverfahren, IZFP, Saarbruecken (Germany)

    1999-08-01

    The electromagnetic and ultrasonic techniques are comparably recent NDT methods for determination of stress states of components. They are simple in application, but require pre-measurement preparation: Electromagnetic techniques need calibration, and quantitative stress analysis by ultrasonic techniques needs reference values, i.e. verified materials-specific quantities to be obtained with representative specimens. Electromagnetic and ultrasonic techniques have been developed for specific tests at defined components, and the corresponding instruments and sensors have been used in practice for several years now. The paper summarizes fundamental aspects and explains the state of the art by means of several examples. (orig./CB) [Deutsch] Elektromagnetische und Ultraschallverfahren sind vergleichsweise neue zerstoerungsfreie Verfahren zur Bestimmung von Eigenspannungen in Bauteilen. Ihre Anwendung ist einfach, setzt aber Vorarbeiten voraus: Elektromagnetische Verfahren muessen kalibriert und zur quantitativen Spannungsanalyse mittels Ultraschallverfahren muessen materialspezifische Kenngroessen an repraesentativen Materialproben ermittelt werden. Elektromagnetische und Ultraschallverfahren sind fuer konkrete Anwendungen an Bauteilen entwickelt, angepasste Geraete und Sensoren seit Jahren in der Nutzung. Der Beitrag fasst die Grundlagen zusammen und stellt den Stand der Technik anhand ausgewaehlter Anwendungen dar. (orig.)

  17. Zur Entwicklung eines interaktiven Verfahrens der Sprachstandsermittlung bei mehrsprachig aufwachsenden Kindern – von der Idee zu ersten Umsetzungsschritten

    Directory of Open Access Journals (Sweden)

    Jörg Roche et al.

    2016-10-01

    Full Text Available Dieser Beitrag skizziert ein Konzept zur Sprachstandsermittlung, das aufbauend auf Ergebnissen der gebrauchsbasierten Spracherwerbsforschung die sprachlichen Fähigkeiten von Vorschulkindern in quasi-natürlichen Gesprächssituationen misst. Den Maßstab bilden dabei die altersgemäßen Deutschkompetenzen monolingualer und bilingualer Kinder im Vorschulalter. Mit dem neuen Verfahren soll eine akkurate Bewertung der kommunikativen Kompetenzen der Kinder am Übergang zur Schule erfolgen, die eine systematische Benachteiligung mehrsprachig aufwachsender Kinder aufgrund von Vergleichen mit zielsprachlichen Erwachsenennormen vermeidet. Das neuartige Erhebungsverfahren wird dabei in Form einer digitalen Spielumgebung (App entwickelt, die eine Umsetzung der Prinzipien des handlungsorientierten Sprachenlernens erlaubt. This paper presents the implementation of a new concept of first and second language assessment for pre-school children between four and six years. The concept is theoretically grounded in usage-based linguistics. It assesses language in authentic communicative settings in a game based app. The settings provide the children with incentives to engage in communication. As a result, the assessment tool does not evaluate formal aspects of language. Instead it relies on functional categories for evaluation. Norms for evaluations are derived from longitudinal corpus studies of authentic child language production. The goal of the new approach is to generate an accurate and fair assessments of the children’s communicative capacities. Pilot studies indicate that children with L2 German appear to be more advanced than shown by traditional form-based assessment methods.

  18. Biodegradable plastics. A contribution to promoting composting in Germany; Bioabbaubare Kunststoffe. Ein Beitrag zur Foerderung der Kompostierung in Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Hamprecht, Jens [BASF SE, Ludwigshafen (Germany)

    2012-11-01

    Up to 80% of all Germans use newspapers for collecting biomass waste, even if it is unhygienic and the paper will soak. This is just one of the many examples of the Germans' readiness to separate waste fractions and save resources. Separation of biomass waste and composting is another field where Germany is ahead of other countries, but the potential is still not fully utilized by far. More hygienic collecting of biomass waste would be possible if biodegradable plastic containers were used. (orig.) [German] Bis zu 80% der Buerger in Deutschland verwenden bisher Zeitung zum Sammeln von Bioabfaellen, selbst wenn es unhygienisch ist und die Zeitung leicht durchweicht. Und das ist nur einer von vielen Beweisen fuer die hohe Bereitschaft der Deutschen zur Abfalltrennung und damit zur Ressourcenschonung. Kein Wunder also, dass in Deutschland auch die Bioabfalltrennung und Kompostierung im Vergleich zu anderen Laendern sehr weit entwickelt ist. Trotzdem ist das Potential noch bei weitem nicht ausgeschoepft. Mit Hilfe von bioabbaubaren Kunststoffen kann den Buergern eine hygienischere Sammlung von Bioabfall ermoeglicht werden. (orig.)

  19. MRI methods for pulmonary ventilation and perfusion imaging; Methoden der MRT zur Ventilations- und Perfusionsbildgebung der Lunge

    Energy Technology Data Exchange (ETDEWEB)

    Sommer, G. [Universitaetsspital Basel, Klinik fuer Radiologie und Nuklearmedizin, Basel (Switzerland); Bauman, G. [Universitaetsspital Basel, Klinik fuer Radiologie und Nuklearmedizin - Radiologische Physik, Basel (Switzerland)

    2016-02-15

    Detektion frueher pathologischer Veraenderungen. Standardverfahren der bildgebenden Lungendiagnostik sind die Computertomographie (CT) zur morphologischen Darstellung und die Perfusions-/Ventilationsszintigraphie bzw. ''single photon emission computed tomography'' (SPECT) zur funktionellen Diagnostik. Zur Darstellung der Lungenventilation stehen die MRT mit hyperpolarisierten Gasen, die O{sub 2}-verstaerkte MRT, die MRT mit fluorierten Gasen und die Fourier-Dekompositions-MRT (FD-MRT) zur Verfuegung. Zur Perfusionsbestimmung koennen die dynamische kontrastmittelverstaerkte MRT (DCE-MRT), das ''arterial spin labeling'' (ASL) und die FD-MRT verwendet werden. Bildgebende Verfahren erlauben einen genaueren Einblick in die Pathophysiologie der Lungenfunktion auf regionaler Ebene. Vorteile der MRT sind die fehlende Strahlenbelastung, welche die schonende Akquisition dynamischer Daten ermoeglicht sowie die Vielfalt der verfuegbaren Kontraste und damit zugaenglichen Parameter der Lungenfunktion. Ausreichende klinische Daten existieren nur fuer bestimmte Anwendungen der DCE-MRT. Fuer die uebrigen Verfahren gibt es lediglich Machbarkeitsstudien und Fallserien mit unterschiedlichem Umfang. Hyperpolarisierte Gase sind technisch bedingt nur eingeschraenkt in der Klinik anwendbar. Ein klinischer Einsatz der genannten Verfahren sollte mit Ausnahme der DCE-MRT nur innerhalb von Studien erfolgen. (orig.)

  20. Assessing lateral flows and solute transport during floods in a conduit-flow-dominated karst system using the inverse problem for the advection-diffusion equation

    Science.gov (United States)

    Cholet, Cybèle; Charlier, Jean-Baptiste; Moussa, Roger; Steinmann, Marc; Denimal, Sophie

    2017-07-01

    The aim of this study is to present a framework that provides new ways to characterize the spatio-temporal variability of lateral exchanges for water flow and solute transport in a karst conduit network during flood events, treating both the diffusive wave equation and the advection-diffusion equation with the same mathematical approach, assuming uniform lateral flow and solute transport. A solution to the inverse problem for the advection-diffusion equations is then applied to data from two successive gauging stations to simulate flows and solute exchange dynamics after recharge. The study site is the karst conduit network of the Fourbanne aquifer in the French Jura Mountains, which includes two reaches characterizing the network from sinkhole to cave stream to the spring. The model is applied, after separation of the base from the flood components, on discharge and total dissolved solids (TDSs) in order to assess lateral flows and solute concentrations and compare them to help identify water origin. The results showed various lateral contributions in space - between the two reaches located in the unsaturated zone (R1), and in the zone that is both unsaturated and saturated (R2) - as well as in time, according to hydrological conditions. Globally, the two reaches show a distinct response to flood routing, with important lateral inflows on R1 and large outflows on R2. By combining these results with solute exchanges and the analysis of flood routing parameters distribution, we showed that lateral inflows on R1 are the addition of diffuse infiltration (observed whatever the hydrological conditions) and localized infiltration in the secondary conduit network (tributaries) in the unsaturated zone, except in extreme dry periods. On R2, despite inflows on the base component, lateral outflows are observed during floods. This pattern was attributed to the concept of reversal flows of conduit-matrix exchanges, inducing a complex water mixing effect in the saturated zone

  1. [Thomas Ditt: „Stoßtruppfakultät Breslau“. Rechtswissenschaft im „Grenzland Schlesien“ 1933-1945. (Beiträge zur Rechtsgeschichte des 20. Jahrhunderts ; 67). Mohr Siebeck. Tübingen 2011] / Marju Luts-Sootak

    Index Scriptorium Estoniae

    Luts-Sootak, Marju, 1966-

    2013-01-01

    Arvustus: Thomas Ditt. „Stoßtruppfakultät Breslau“. Rechtswissenschaft im „Grenzland Schlesien“ 1933-1945. (Beiträge zur Rechtsgeschichte des 20. Jahrhunderts, Bd. 67.) Mohr Siebeck. Tübingen 2011

  2. [Manfred Schneider. Lübeck im 12. und 13. Jahrhundert. Archäologische Befunde zur entstehung einer mittelalterlichen Grossstadt. In : Expansion - integration? Danish-Baltic Contacts 1147-1410] / Dennis Hortmuth

    Index Scriptorium Estoniae

    Hortmuth, Dennis

    2011-01-01

    Arvustus:Manfred Schneider. Lübeck im 12. und 13. Jahrhundert. Archäologische Befunde zur entstehung einer mittelalterlichen Grossstadt. In : Expansion - integration? Danish-Baltic Contacts 1147-1410 AD. (Vordingborg, 2009).

  3. Advanced data processing of airborne electromagnetic data for imaging hidden conduit networks in the coastal karst plain of Tulum (Mexico)

    International Nuclear Information System (INIS)

    Schiller, A.; Schattauer, I.; Ottowitz, D.

    2016-01-01

    This study is part of a series of international research cooperations which commenced in 2007 and are still ongoing. The study area is located on the east coast of the Yucatan Peninsula, Mexico, and comprises the northern most part of the Sian Kaan biosphere reserve, a coastal wetland of international importance, as well as the city of Tulum in the state of Quintana Roo, and part of the second largest barrier reef in the world some 300 metres to one kilometre off shore. Two airborne surveys, conducted in 2007 and 2008 by the Geological Survey of Austria, covered an area of some 200 square kilometres, including the well-known Ox Bel Ha cave system, already mapped by exploration divers. In order to get additional ground truth data and input for the hydrological model, extended ground geophysical campaigns have been conducted an - nually. The first processing of the airborne electromagnetic (AEM) data revealed not only a clear signature from known caves but also the image of a vast, unexplored, hidden conduit network. However, lateral and depth resolution was limited due to measurement drift and noise as well the specific behaviour of the ap - plied inversion technique. Newly developed algorithms for processing AEM data and inversion results have improved the signal-to-noise ratio significantly and enabled the imaging of well defined structures in the underground. Therefore, the AEM method is now capable of quickly deliver crucial structural information of karst-water regimes in difficult accessible areas with unique depth information compared to previous studies. (Author)

  4. Reimplantation valve-sparing aortic root replacement in Marfan syndrome using the Valsalva conduit: an intercontinental multicenter study.

    Science.gov (United States)

    Settepani, Fabrizio; Szeto, Wilson Y; Pacini, Davide; De Paulis, Ruggero; Chiariello, Luigi; Di Bartolomeo, Roberto; Gallotti, Roberto; Bavaria, Joseph E

    2007-02-01

    Introduced by DePaulis in 2000, the Gelweave Valsalva graft (Sulzer Vascutek, Refrewshire, Scotland) is a modified Dacron conduit (DuPont, Wilmington, DE), with prefashioned sinuses of Valsalva. The aim of this study was to evaluate the mid-term results of the reimplantation valve-sparing aortic root replacement using the Gelweave Valsalva prosthesis in Marfan syndrome patients. A retrospective review was performed of 35 patients with Marfan syndrome in four centers who underwent the reimplantation valve-sparing aortic root replacement using the Gelweave Valsalva prosthesis. The patients were predominantly men, with a mean age of 36.5 +/- 12.6 years (range, 14 to 62 years). Two patients presented with acute type A dissections and underwent emergent operations. Elective hemiarch reconstruction using hypothermic circulatory arrest was required in 11 patients. Aortic valve cusp repair was performed in 2 patients. There were no operative or hospital deaths, and no patients died during follow-up. The mean follow-up was 19 months (range, 1 to 60 months). Significant (>2+) aortic insufficiency (AI), requiring aortic valve replacement, developed in 3 patients during follow-up that requiring aortic valve replacement. The 5-year freedom from reoperation owing to structural valve deterioration was 88.9% +/- 8.1%. There were no episodes of clinically significant thromboembolism. Reimplantation valve-sparing aortic root replacement with the Gelweave Valsalva prosthesis in Marfan patients provides satisfactory mid-term results, thus encouraging further use of this type of repair. However, long-term results are needed in order to define the durability of this technique.

  5. Can nerve regeneration on an artificial nerve conduit be enhanced by ethanol-induced cervical sympathetic ganglion block?

    Directory of Open Access Journals (Sweden)

    Yoshiki Shionoya

    Full Text Available This study aimed to determine whether nerve regeneration by means of an artificial nerve conduit is promoted by ethanol-induced cervical sympathetic ganglion block (CSGB in a canine model. This study involved two experiments-in part I, the authors examined the effect of CSGB by ethanol injection on long-term blood flow to the orofacial region; part II involved evaluation of the effect of CSGB by ethanol injection on inferior alveolar nerve (IAN repair using polyglycolic acid-collagen tubes. In part I, seven Beagles were administered left CSGB by injection of 99.5% ethanol under direct visualization by means of thoracotomy, and changes in oral mucosal blood flow in the mental region and nasal skin temperature were evaluated. The increase in blood flow on the left side lasted for 7 weeks, while the increase in average skin temperature lasted 10 weeks on the left side and 3 weeks on the right. In part II, fourteen Beagles were each implanted with a polyglycolic acid-collagen tube across a 10-mm gap in the left IAN. A week after surgery, seven of these dogs were administered CSGB by injection of ethanol. Electrophysiological findings at 3 months after surgery revealed significantly higher sensory nerve conduction velocity and recovery index (ratio of left and right IAN peak amplitudes after nerve regeneration in the reconstruction+CSGB group than in the reconstruction-only group. Myelinated axons in the reconstruction+CSGB group were greater in diameter than those in the reconstruction-only group. Administration of CSGB with ethanol resulted in improved nerve regeneration in some IAN defects. However, CSGB has several physiological effects, one of which could possibly be the long-term increase in adjacent blood flow.

  6. Can nerve regeneration on an artificial nerve conduit be enhanced by ethanol-induced cervical sympathetic ganglion block?

    Science.gov (United States)

    Sunada, Katsuhisa; Shigeno, Keiji; Nakada, Akira; Honda, Michitaka; Nakamura, Tatsuo

    2017-01-01

    This study aimed to determine whether nerve regeneration by means of an artificial nerve conduit is promoted by ethanol-induced cervical sympathetic ganglion block (CSGB) in a canine model. This study involved two experiments—in part I, the authors examined the effect of CSGB by ethanol injection on long-term blood flow to the orofacial region; part II involved evaluation of the effect of CSGB by ethanol injection on inferior alveolar nerve (IAN) repair using polyglycolic acid-collagen tubes. In part I, seven Beagles were administered left CSGB by injection of 99.5% ethanol under direct visualization by means of thoracotomy, and changes in oral mucosal blood flow in the mental region and nasal skin temperature were evaluated. The increase in blood flow on the left side lasted for 7 weeks, while the increase in average skin temperature lasted 10 weeks on the left side and 3 weeks on the right. In part II, fourteen Beagles were each implanted with a polyglycolic acid-collagen tube across a 10-mm gap in the left IAN. A week after surgery, seven of these dogs were administered CSGB by injection of ethanol. Electrophysiological findings at 3 months after surgery revealed significantly higher sensory nerve conduction velocity and recovery index (ratio of left and right IAN peak amplitudes) after nerve regeneration in the reconstruction+CSGB group than in the reconstruction-only group. Myelinated axons in the reconstruction+CSGB group were greater in diameter than those in the reconstruction-only group. Administration of CSGB with ethanol resulted in improved nerve regeneration in some IAN defects. However, CSGB has several physiological effects, one of which could possibly be the long-term increase in adjacent blood flow. PMID:29220373

  7. AC loss performance of cable-in-conduit conductor. Influence of cable mechanical property on coupling loss reduction

    International Nuclear Information System (INIS)

    Matsui, Kunihiro; Koizumi, Norikiyo; Isono, Takaaki; Hamada, Kazuya; Nunoya, Yoshihiko

    2003-01-01

    The ITER Central Solenoid (CS) model coil, CS Insert and Nb 3 Al Insert were developed and tested from 2000 to 2002. The AC loss performances of these coils were investigated in various experiments. In addition, the AC losses of the CS and Nb 3 Al Insert conductors were measured using short CS and Nb 3 Al Insert conductors before the coil tests. The coupling time constants of these conductors were estimated to be 30 and 120 ms, respectively. On the other hand, the test results of the CS and Nb 3 Al Inserts show that the coupling currents induced in these conductors had multiple decay time constants. In fact, the existence of the coupling currents with long decay time constants, the order of which was in the thousands of seconds, was directly observed with hall sensors and voltage taps. Moreover, the AC loss test results show that electromagnetic force decreases coupling losses with exponential decay constants. This is because the weak sinter among the strands, which originated during heat treatment, was broken due to the electromagnetic force, and then the contact resistance among strands increased. It was found that this exponential decay constant was the function of a gap (i.e., a mechanical property of the cable) created between the cable and conduit due to electromagnetic force. The gap can be estimated by pressure drop, measured under the electromagnetic force. The pressure drop can easily be measured at an initial trial charge, and then it is possible to estimate the exponential decay constant before normal coil operation. Accordingly, it is possible to predict promptly how many times the trial operations are necessary to decrease the coupling losses to the designed value by measuring the coupling losses and the pressure drop during the initial coil operation trial. (author)

  8. Pathological changes of the chemosensory function in multiple sclerosis. An MRI study; Pathologische Veraenderungen der Chemosensorik mittels Kernspintomografie bei Multipler Sklerose. Eine MRT-Studie

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, F.A.; Harms, L. [Charite Campus Mitte, Berlin (Germany). Dept. of Neurology - Consultation Service for Multiple Sclerosis; Fleiner, F.; Dahlslett, B.; Goektas, Oe. [Charite Campus Mitte, Berlin (Germany). Dept. of Otolaryngology, Head and Neck Surgery; Bohner, G.; Erb, K.; Luedemann, L. [Charite Campus Mitte, Berlin (Germany). Dept. of Radiology

    2011-06-15

    Purpose: To examine possible causes for olfactory and gustatory dysfunction in MS patients in a prospective study with MRI. Materials and Methods: 30 MS patients (21 women, 11 men, 22 - 65 years, diameter 42 years) were examined by MRI. The olfactory bulb (OB) and olfactory brain volume was correlated with the number and volume of MS lesions in the olfactory brain and the non-olfactory brain. Olfactory testing was performed using the Threshold-Discrimination-Identification Test (TDI), and gustatory function was tested using the Taste-Strips-Test (TST). Results: 33 % of the MS patients displayed olfactory dysfunction (8 % of the control group), and 17 % displayed gustatory dysfunction (5 % of the control group). There was a correlation between the olfactory brain volume and the number (r = -0.38, p < 0.05) and volume (r = -0.38, p < 0.05) of MS lesions in the olfactory brain. The olfactory brain volume correlated with the number of MS lesions in the non-olfactory brain (r = -0.48, p < 0.05). The volume of the left OB correlated with the volume of MS lesions in the olfactory brain (r = -0.42, p < 0.05), the number (r = 0.37, p < 0.05) and volume (r = 0.4, p < 0.05) of lesions in the left part of the olfactory brain and with the TST score (r = -0.45, p < 0.05). The TST score correlated with the volume of lesions in the left (r = -0.45, p < 0.05) and right part (r = -0.53, p < 0.05) of the olfactory brain. The TST score correlated with the number of lesions in the non-olfactory brain (r = -0.48, p < 0.05). Conclusion: The correlation between a higher number and volume of MS lesions in the olfactory brain with a decreased OB and olfactory brain volume could help to explain olfactory and gustatory dysfunction in MS patients. Just the left OB correlated with the number and volume of lesions in the olfactory brain. Manual segmentation was a suitable method for measuring OB and olfactory brain volume. (orig.)

  9. Development of an exhaust sensor for control of internal combustion engines and exhaust treatment systems - CatSens. Final report; Entwicklung eines Abgassensors zur Regelung von Verbrennungsmotoren und Abgasnachbehandlungssystemen - CatSens. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Lepperhoff, G.; Milanovic, I.

    2002-05-01

    A sensor system for controlling combustion processes in small-scale furnaces and internal combustion engines and for on-board diagnosis of exhaust treatment systems, e.g. NO{sub x} adsorber catalytic converters in motor cars, was developed. [German] Im Rahmen des Verbundprojektes soll ein Sensorsystem zur Regelung der Verbrennungsprozesse in Kleinfeuerungsanlagen und Verbrennungsmotoren sowie zur Regelung und Ueberwachung (On-Board Diagnose) von Abgasnachbehandlungseinrichtungen wie z.B. NO{sub x}-Adsorberkatalysatoren in Kraftfahrzeugen, entwickelt werden. (orig.)

  10. [Rolf Hammel-Kiesow. Der Lübecker Katasterplan des 19. Jahrhunderts als historische Quelle. Überlegungen zur Stadtentwicklung Lübecks aus archäologischer, historischer und bauhistorischen Zicht] / Dennis Hormuth

    Index Scriptorium Estoniae

    Hormuth, Dennis

    2013-01-01

    Arvustus : Rolf Hammel-Kiesow. Der LÜbecker Katasterplan des 19. Jahrhunderts als historische Quelle. Überlegungen zur Stadtentwicklung Lübecks aus archäologischer, historischer und bauhistorischen Sicht. In: Stadtgründung und Stadterweiterung. Beiträge von Archäologie und Stadtgeschichtsforschung (=Beiträge zur Geschichte der Städte Mitteleuropas XXII). Linz, 2011. S. 75-104

  11. A new verification method for vehicle electronics; Ein neues Testverfahren zur Verifikation der Fahrzeugelektrik/-elektronik

    Energy Technology Data Exchange (ETDEWEB)

    Sigwart, A.; Bockemuehl, P. [Ford-Werke AG, Koeln (Germany)

    2001-07-01

    anstelle des Fahrers die Bedienung aller elektrischen/elektronischen Komponenten uebernimmt. Als Anlage steht ein Strassensimulator (4-Stempelanlage) in einer Klimakammer zur Verfuegung. In einer automatisierten Ablaufsteuerung wird die Anregung durch die Strasse verbunden mit den Umgebungsbedingungen (Temperatur, Feuchte, Sonnenlicht) und kombiniert mit den Betaetigungen der elektrischen Komponenten durch den Roboter. Mit diesem Verfahren ist es moeglich, Kundengebrauchsprofile realitaetsgetreu zu simulieren und in kurzer Zeit eine Lebensdauer von 10 Jahren zu absolvieren. (orig.)

  12. Guideline for in vivo- and in vitro procedures for thyroid diseases. Version 2; Leitlinie zur Schilddruesendiagnostik. Version 2

    Energy Technology Data Exchange (ETDEWEB)

    Dietlein, M.; Dressler, J.; Gruenwald, F.; Joseph, K.; Leisner, B.; Moser, E.; Reiners, C.; Rendl, J.; Schicha, H.; Schneider, P.; Schober, O. [Deutsche Gesellschaft fuer Nuklearmedizin (DGN) (Germany)

    2003-06-01

    The version 2 of the guideline for diagnostic standards of thyroid disorders is an update of the guideline published in 1999 and describes standards of in vitro and in vivo procedures. The following statements are modified: In vitro procedures: When measurement of the TSH-receptor antibodies is indicated, the guideline recommends the use of a second generation assay (recombinant human TSH-receptor as antigen). The functional assay sensitivity for the measurement of thyroglobulin should reach a value {<=}1 ng/ml. Moleculargenetic tests (RET proto-oncogen) are indicated in patients with a newly diagnosed medullary thyroid cancer and in the relatives of patients with hereditary medullary thyroid cancer. In vivo procedures: The sonographic examination should use a probe with a frequency of at least 7.5 MHz. Indications for the thyroid scintigraphy: nodule size {>=}1 cm in diameter, autonomous goitre/nodule with clinical or subclinical hyperthyroidism, necessity of a differentiation between Graves' disease and chronic lymphocytic thyroiditis, therapy control after a definitive treatment and - in individual cases - the follow-up of untreated autonomous nodules. (orig.) [German] Mit der Version 2 der Leitlinie zur Schilddruesendiagnostik wird die 1999 publizierte Leitlinie aktualisiert. Die Leitlinie behandelt sowohl In-vitro- als auch In-vivo-Diagnostik. Die Aenderungen umfassen folgende Aspekte: In-vitro-Diagnostik: Zur Messung der Antikoerper gegen den TSH-Rezeptor werden Assaysysteme der zweiten Generation empfohlen, bei denen der rekombinante humane TSH-Rezeptor als Antigen eingesetzt wird. Die funktionelle Assaysensitivitaet der Thyreoglobulinbestimmung sollte {<=}1 ng/ml betragen. Molekulargenetische Untersuchungen (RET Protoonkogen) haben ihren Platz bei der Erstmanifestation eines medullaeren Schilddruesenkarzinoms und im Familienscreening, falls eine hereditaere Form des medullaeren Schilddruesenkarzinoms vorliegt. In-vivo-Diagnostik: Die sonographische

  13. Conduit grinding apparatus

    Science.gov (United States)

    Nachbar, Henry D.; Korytkowski, Alfred S.

    1991-01-01

    A grinding apparatus for grinding the interior portion of a valve stem receiving area of a valve. The apparatus comprises a faceplate, a plurality of cams mounted to an interior face of the faceplate, a locking bolt to lock the faceplate at a predetermined position on the valve, a movable grinder and a guide tube for positioning an optical viewer proximate the area to be grinded. The apparatus can either be rotated about the valve for grinding an area of the inner diameter of a valve stem receiving area or locked at a predetermined position to grind a specific point in the receiving area.

  14. Gas-operated heat pump for monovalent space heating and tap water heating. A seizable contribution to carbon dioxide emission control; Gasbetriebene Waermepumpe zur monovalenten Raumbeheizung und Trinkwassererwaermung. Ein greifbarer Beitrag zur Reduktion der CO{sub 2}-Emissionen

    Energy Technology Data Exchange (ETDEWEB)

    Heikrodt, K.; Heckt, R. [Viessmann Werke GmbH und Co., Allendorf (Germany)

    1999-07-01

    The project had the objectives to develop a Vuilleumier heat pump for space heating and make an experimental study testing it as a heat generator for a heating system for one- and multi-family houses. Apart from monovalent operation, the following boundary conditions were defined: provision for connection to existing heating systems, even radiator heatings with 75 C/60 C, tap water heating, and air-source heat. Performance constant, manufacturing cost, freedom from maintenance, and service life were taken into consideration in the design, rating and construction of the unit. (orig.) [German] Ziel des Vorhabens war die Entwicklung einer Vuilleumier-Waermepumpe zur Raumbeheizung und deren experimentelle Untersuchung als Waermeerzeuger fuer ein Heizungssystem in Ein- und Mehrfamilienhaeusern. Als Rahmebedingungen wurden neben einer monovalenten Betriebsweise auch die moegliche Anbindung an bestehende Heizungssysteme, sogar Radiatorheizungen mit 75 C/60 C, Trinkwassererwaermung und Luft als Waermequelle festgelegt. Leistungszahl, Herstellkosten, Wartungsfreiheit und Lebensdauer wurden in Konzeption, Auslegung und Konstruktion beruecksichtigt. (orig.)

  15. Modification of the method of Figgie for determination of joint line shifting in total knee arthroplasty; Modifizierung der Messmethode nach Figgie zur Bestimmung der Gelenklinienverschiebung in der Knieendoprothetik

    Energy Technology Data Exchange (ETDEWEB)

    Classen, T.; Wegner, A.; Knoch, M. von [Universitaet Duisburg-Essen, Klinik fuer Orthopaedie, Essen (Germany)

    2009-06-15

    An important factor for a good result after total knee arthroplasty is the position of the patella in relation to the tibiofemoral joint line. The position of the patella itself is not influenced by arthroplasty, therefore any changes in the position of the tibiofemoral joint line are of special interest. The Figgie method to describe patella height delivers only absolute measurements, which makes it difficult to compare different radiographs. For this reason we developed a new JL/P quotient (JL: distance from the tibial plateau to the tibial tubercle, P: distance from the inferior pole of the patella to the tibial plateau) to enable better comparison. Furthermore, we modified the JL/P quotient and instead of taking the tibial plateau as the reference line, we constructed a tangent on the femoral condyle. With this modification, problems such as tibial inlays of different heights which have to be taken into account in the measurements, the slope of the tibial component or difficult assessment of the tibial joint surface in osteoarthritic knees do not arise. The JL/P quotient shows massive shift to cranialisation of the tibiofemoral joint line which does not correspond to reality. The modified method also shows cranialisation of the tibiofemoral joint line, but in a realistic way. Both methods show a minimal interobserver variability. The modified JL/P quotient seems to be a good method for determining the shift in the tibiofemoral joint line after total knee arthroplasty. (orig.) [German] Ein bedeutender Faktor fuer ein gutes postoperatives Ergebnis nach einer Knieendoprothesenimplantation ist die Stellung der Patella in Relation zur tibiofemoralen Gelenklinie. Da die Stellung der Patella durch den operativen Eingriff primaer nicht beeinflusst wird, liegt besonderes Augenmerk auf den Veraenderungen der Gelenklinie des Tibiofemoralgelenks. Die Messmethode zur Bestimmung der Patellahoehe nach Figgie liefert dafuer nur absolute Werte, was eine Vergleichbarkeit von

  16. Chilling of dormant buds hyperinduces FLOWERING LOCUS T and recruits GA-inducible 1,3-beta-glucanases to reopen signal conduits and release dormancy in Populus.

    Science.gov (United States)

    Rinne, Päivi L H; Welling, Annikki; Vahala, Jorma; Ripel, Linda; Ruonala, Raili; Kangasjärvi, Jaakko; van der Schoot, Christiaan

    2011-01-01

    In trees, production of intercellular signals and accessibility of signal conduits jointly govern dormancy cycling at the shoot apex. We identified 10 putative cell wall 1,3-β-glucanase genes (glucan hydrolase family 17 [GH17]) in Populus that could turn over 1,3-β-glucan (callose) at pores and plasmodesmata (PD) and investigated their regulation in relation to FT and CENL1 expression. The 10 genes encode orthologs of Arabidopsis thaliana BG_ppap, a PD-associated glycosylphosphatidylinositol (GPI) lipid-anchored protein, the Arabidopsis PD callose binding protein PDCB, and a birch (Betula pendula) putative lipid body (LB) protein. We found that these genes were differentially regulated by photoperiod, by chilling (5°C), and by feeding of gibberellins GA(3) and GA(4). GA(3) feeding upregulated all LB-associated GH17s, whereas GA(4) upregulated most GH17s with a GPI anchor and/or callose binding motif, but only GA(4) induced true bud burst. Chilling upregulated a number of GA biosynthesis and signaling genes as well as FT, but not CENL1, while the reverse was true for both GA(3) and GA(4). Collectively, the results suggest a model for dormancy release in which chilling induces FT and both GPI lipid-anchored and GA(3)-inducible GH17s to reopen signaling conduits in the embryonic shoot. When temperatures rise, the reopened conduits enable movement of FT and CENL1 to their targets, where they drive bud burst, shoot elongation, and morphogenesis.

  17. Comparison of the air-Q intubating laryngeal airway and the cobra perilaryngeal airway as conduits for fiber optic-guided intubation in pediatric patients.

    Science.gov (United States)

    Girgis, Karim K; Youssef, Maha M I; ElZayyat, Nashwa S

    2014-10-01

    One of the methods proposed in cases of difficult airway management in children is using a supraglottic airway device as a conduit for tracheal intubation. The aim of this study was to compare the efficacy of the Air-Q Intubating Laryngeal Airway (Air-Q) and the Cobra Perilaryngeal Airway (CobraPLA) to function as a conduit for fiber optic-guided tracheal intubation in pediatric patients. A total of 60 children with ages ranging from 1 to 6 years, undergoing elective surgery, were randomized to have their airway managed with either an Air-Q or CobraPLA. Outcomes recorded were the success rate, time and number of attempts required for fiber optic-guided intubation and the time required for device removal after intubation. We also recorded airway leak pressure (ALP), fiber optic grade of glottic view and occurrence of complications. Both devices were successfully inserted in all patients. The intubation success rate was comparable with the Air-Q and the CobraPLA (96.7% vs. 90%), as was the first attempt success rate (90% vs. 80%). The intubation time was significantly longer with the CobraPLA (29.5 ± 10.9 s vs. 23.2 ± 9.8 s; P fiber optic grade of glottic view was comparable with the two devices. The CobraPLA was associated with a significantly higher incidence of blood staining of the device on removal and post-operative sore throat. Both the Air-Q and CobraPLA can be used effectively as a conduit for fiber optic-guided tracheal intubation in children. However, the Air-Q proved to be superior due to a shorter intubation time and less airway morbidity compared with the CobraPLA.

  18. Zur Politik der Intertextualität in Roberto Bolaños ‚Estrella Distante‘

    Directory of Open Access Journals (Sweden)

    Samir Sellami

    2014-12-01

    Full Text Available Am Beispiel von Bolaños 1996 erschienenem Kurzroman Estrella Distante untersucht der Beitrag die spezifische Logik der Intertextualität in Bolaños Poetik. Seine implizite Logik der Intertextualität entwickelt sich dabei nicht im luftleeren Raum, sondern im Kontrastverhältnis zu der erzählten Poetik des Protagonisten Carlos Wieder. Dessen formal progressive, aber politisch reaktionär motivierte Poetik deckt die fundamentale Ambivalenz avantgardistischer Poetiken auf und führt zur gegensätzlichen Affirmation einer metabolischen Intertextualität, die den körperlichen und gelebten Kontakt mit dem Literarischen in den Vordergrund stellt. In dieser Konstellation wird Estrella Distante lesbar als poetischer Widerstand und literarische Vergeltung an der historischen Wirklichkeit.

  19. E-Learning als Möglichkeit zur Unterstützung des selbstgesteuerten Lernens an Berufsschulen

    Directory of Open Access Journals (Sweden)

    Silvia Dreer

    2008-06-01

    Full Text Available Im Mittelpunkt dieses Beitrages steht die Frage, wie durch die Potenziale von ELearning selbstgesteuertes Lernen an berufsbildenden Schulen (Berufsschulen unterstützt werden kann und wie diese neuen Lernangebote im Unterricht effektiv genutzt werden können. Dann werden bereits vorhandene empirische Belege zum selbstgesteuerten Lernen aufgearbeitet und unterschiedliche Möglichkeiten zur Förderung des selbstgesteuerten Lernens betrachtet bzw. welche Lernumgebungen notwendig sind, um selbstgesteuertes Lernen zu ermöglichen. Es wird auf die Besonderheiten von E-Learning eingegangen und eine mediendidaktische Konzeption realisiert. Im Rahmen der empirischen Untersuchung wird untersucht, ob selbstgesteuertes Lernen durch E-Learning unterstützt werden kann. Den Abschluss bildet eine Abschätzung des mediendidaktischen Potenzials von Lernumgebungen die selbstgesteuertes Lernen unterstützen in Hinblick auf den Unterricht in berufsbildenden Schulen.

  20. Lean management - an effective way to arrange maintenance?; Lean Management - ein effektiver Weg zur Gestaltung der Instandhaltung?

    Energy Technology Data Exchange (ETDEWEB)

    Tschuschke, W. [Inst. fuer Instandhaltung gGmbH, Iserlohn (Germany)

    1996-08-01

    Lean management/lean production wishes to attain more through intelligent operation system/production at less expense (personnel, materials, energy, costs). The object is not harder but more intelligent and production work; we do not need to run faster but to find shorter routes. The idea of lean management`s effects and changes have consequences for the field of maintenance as an equivalent and legitimate business area which are discussed in this paper. (orig.) [Deutsch] Lean Management/Lean Production will durch ein intelligentes Arbeitssystem/Produzieren mit weniger Aufwand (Personal, Material, Energie, Kosten) mehr erreichen. Ziel ist nicht das haertere, sondern das intelligentere und produktivere Arbeiten; wir sollen nicht schneller laufen, sondern kuerzere Wege finden. Fuer den Bereich Instandhaltung als gleichwertiger und gleichberechtigter Unternehmensbereich haben die Gedanken des Lean Managements Auswirkungen und Veraenderungen zur Folge, die im Beitrag genannt werden. (orig.)