Upgraded Fast Beam Conditions Monitor for CMS online luminosity measurement

CERN Document Server

Leonard, Jessica Lynn

2014-01-01

The CMS beam and radiation monitoring subsystem BCM1F during LHC Run I consisted of 8 individual diamond sensors situated around the beam pipe within the tracker detector volume, for the purpose of fast monitoring of beam background and collision products. Effort is ongoing to develop the use of BCM1F as an online bunch-by-bunch luminosity monitor. BCM1F will be running whenever there is beam in LHC, and its data acquisition is independent from the data acquisition of the CMS detector, hence it delivers luminosity even when CMS is not taking data. To prepare for the expected increase in the LHC luminosity and the change from 50 ns to 25 ns bunch separation, several changes to the system are required, including a higher number of sensors and upgraded electronics. In particular, a new real-time digitizer with large memory was developed and is being integrated into a multi-subsystem framework for luminosity measurement. Current results from Run II preparation will be shown, including results from the January 201...

A new luminometer and beam conditions monitor for the CMS experiment

Energy Technology Data Exchange (ETDEWEB)

Karacheban, Olena; Hempel, Maria [Brandenburg University of Technology, Cottbus (Germany); DESY, Zeuthen (Germany); Dabrowski, Anne; Ryjov, Vladimir; Stickland, David; Zagozdzinska, Agnieszka [CERN, Geneva (Switzerland); Henschel, Hans; Lange, Wolfgang [DESY, Zeuthen (Germany); Leonard, Jessica; Walsh, Roberval [DESY, Hamburg (Germany); Levy, Itamar [Tel Aviv University, Tel Aviv (Israel); Lohmann, Wolfgang [Brandenburg University of Technology, Cottbus (Germany); RWTH Aachen University, Aachen (Germany); Przyborowski, Dominik [AGH-UST University, Cracow (Poland); Schuwalow, Sergej [DESY, Zeuthen (Germany); DESY, Hamburg (Germany)

2016-07-01

The luminosity is a key quantity of any collider, which allows for the determination of the absolute cross sections from the observed rate in a detector. The Fast Beam Conditions Monitor (BCM1F) was upgraded in the last LHC long technical stop (LS1) to 24 diamond sensors read out by a dedicated fast ASIC in 130 nm CMOS technology. The backend comprises a deadtime-less histogramming unit, with a 6.25 ns bin width, in VME standard. A microTCA system with better time resolution is in development. BCM1F is used for luminosity and machine induced background measurements at the CMS experiment. The performance of the detector in the first running period, as well as results on the calibration (Van-der-Meer scan) and the measurements of the luminosity are presented.

Measurements of the performance of a beam condition monitor prototype in a 5 GeV electron beam

Energy Technology Data Exchange (ETDEWEB)

Hempel, M., E-mail: maria.hempel@desy.de [Brandenburg University of Technology Cottbus-Senftenberg, Cottbus 03013 (Germany); DESY, Zeuthen 15738 (Germany); Afanaciev, K. [NCPHEP, Minsk 220040 (Belarus); Burtowy, P.; Dabrowski, A. [CERN, Geneva 1211 (Switzerland); Henschel, H. [DESY, Zeuthen 15738 (Germany); Idzik, M. [AGH University of Science and Technology, Cracow 30-059 (Poland); Karacheban, O. [Brandenburg University of Technology Cottbus-Senftenberg, Cottbus 03013 (Germany); Lange, W.; Leonard, J. [DESY, Zeuthen 15738 (Germany); Levy, I. [Tel Aviv University, Tel Aviv 6997801 (Israel); Lohmann, W. [Brandenburg University of Technology Cottbus-Senftenberg, Cottbus 03013 (Germany); DESY, Zeuthen 15738 (Germany); Pollak, B. [Northwestern University, Evanston, IL 60208 (United States); Przyborowski, D. [AGH University of Science and Technology, Cracow 30-059 (Poland); Ryjov, V. [CERN, Geneva 1211 (Switzerland); Schuwalow, S. [DESY, Zeuthen 15738 (Germany); Stickland, D. [Princeton University, Princeton, NJ 08544 (United States); Walsh, R. [DESY, Zeuthen 15738 (Germany); Zagozdzinska, A. [CERN, Geneva 1211 (Switzerland)

2016-08-01

The Fast Beam Conditions Monitor, BCM1F, in the Compact Muon Solenoid, CMS, experiment was operated since 2008 and delivered invaluable information on the machine induced background in the inner part of the CMS detector supporting a safe operation of the inner tracker and high quality data. Due to the shortening of the time between two bunch crossings from 50 ns to 25 ns and higher expected luminosity at the Large Hadron Collider, LHC, in 2015, BCM1F needed an upgrade to higher bandwidth. In addition, BCM1F is used as an on-line luminometer operated independently of CMS. To match these requirements, the number of single crystal diamond sensors was enhanced from 8 to 24. Each sensor is subdivided into two pads, leading to 48 readout channels. Dedicated fast front-end ASICs were developed in 130 nm technology, and the back-end electronics is completely upgraded. An assembled prototype BCM1F detector comprising sensors, a fast front-end ASIC and optical analog readout was studied in a 5 GeV electron beam at the DESY-II accelerator. Results on the performance are given.

Bone conditioned media (BCM) improves osteoblast adhesion and differentiation on collagen barrier membranes.

Science.gov (United States)

Fujioka-Kobayashi, Masako; Caballé-Serrano, Jordi; Bosshardt, Dieter D; Gruber, Reinhard; Buser, Daniel; Miron, Richard J

2016-07-04

The use of autogenous bone chips during guided bone regeneration procedures has remained the gold standard for bone grafting due to its excellent combination of osteoconduction, osteoinduction and osteogenesis. Recent protocols established by our group have characterized specific growth factors and cytokines released from autogenous bone that have the potential to be harvested and isolated into bone conditioned media (BCM). Due to the advantageous osteo-promotive properties of BCM, the aims of the present study was to pre-coat collagen barrier membranes with BCM and investigate its effect on osteoblast adhesion, proliferation and differentiation for possible future clinical use. Scanning electron microscopy (SEM) was first used to qualitative assess BCM protein accumulation on the surface of collagen membranes. Thereafter, undifferentiated mouse ST2 stromal bone marrow cells were seeded onto BioGide porcine derived collagen barrier membranes (control) or barrier membranes pre-coated with BCM (test group). Control and BCM samples were compared for cell adhesion at 8 h, cell proliferation at 1, 3 and 5 days and real-time PCR at 5 days for osteoblast differentiation markers including Runx2, alkaline phosphatase (ALP), osteocalcin (OCN) and bone sialoprotein (BSP). Mineralization was further assessed with alizarin red staining at 14 days post seeding. SEM images demonstrated evidence of accumulated proteins found on the surface of collagen membranes following coating with BCM. Analysis of total cell numbers revealed that the additional pre-coating with BCM markedly increased cell attachment over 4 fold when compared to cells seeded on barrier membranes alone. No significant difference could be observed for cell proliferation at all time points. BCM significantly increased mRNA levels of osteoblast differentiation markers including ALP, OCN and BSP at 5 days post seeding. Furthermore, barrier membranes pre-coated with BCM demonstrated a 5-fold increase in alizarin

ATLAS diamond Beam Condition Monitor

CERN Document Server

Gorišek, A; Dolenc, I; Frais-Kölbl, H; Griesmayer, E; Kagan, H; Korpar, S; Kramberger, G; Mandic, I; Meyer, M; Mikuz, M; Pernegger, H; Smith, S; Trischuk, W; Weilhammer, P; Zavrtanik, M

2007-01-01

The ATLAS experiment has chosen to use diamond for its Beam Condition Monitor (BCM) given its radiation hardness, low capacitance and short charge collection time. In addition, due to low leakage current diamonds do not require cooling. The ATLAS Beam Condition Monitoring system is based on single beam bunch crossing measurements rather than integrating the accumulated particle flux. Its fast electronics will allow separation of LHC collisions from background events such as beam gas interactions or beam accidents. There will be two stations placed symmetrically about the interaction point along the beam axis at . Timing of signals from the two stations will provide almost ideal separation of beam–beam interactions and background events. The ATLAS BCM module consists of diamond pad detectors of area and thickness coupled to a two-stage RF current amplifier. The production of the final detector modules is almost done. A S/N ratio of 10:1 has been achieved with minimum ionizing particles (MIPs) in the test bea...

ATLAS diamond Beam Condition Monitor

Energy Technology Data Exchange (ETDEWEB)

Gorisek, A. [CERN (Switzerland)]. E-mail: andrej.gorisek@cern.ch; Cindro, V. [J. Stefan Institute (Slovenia); Dolenc, I. [J. Stefan Institute (Slovenia); Frais-Koelbl, H. [Fotec (Austria); Griesmayer, E. [Fotec (Austria); Kagan, H. [Ohio State University, OH (United States); Korpar, S. [J. Stefan Institute (Slovenia); Kramberger, G. [J. Stefan Institute (Slovenia); Mandic, I. [J. Stefan Institute (Slovenia); Meyer, M. [CERN (Switzerland); Mikuz, M. [J. Stefan Institute (Slovenia); Pernegger, H. [CERN (Switzerland); Smith, S. [Ohio State University, OH (United States); Trischuk, W. [University of Toronto (Canada); Weilhammer, P. [CERN (Switzerland); Zavrtanik, M. [J. Stefan Institute (Slovenia)

2007-03-01

The ATLAS experiment has chosen to use diamond for its Beam Condition Monitor (BCM) given its radiation hardness, low capacitance and short charge collection time. In addition, due to low leakage current diamonds do not require cooling. The ATLAS Beam Condition Monitoring system is based on single beam bunch crossing measurements rather than integrating the accumulated particle flux. Its fast electronics will allow separation of LHC collisions from background events such as beam gas interactions or beam accidents. There will be two stations placed symmetrically about the interaction point along the beam axis at z=+/-183.8cm. Timing of signals from the two stations will provide almost ideal separation of beam-beam interactions and background events. The ATLAS BCM module consists of diamond pad detectors of 1cm{sup 2} area and 500{mu}m thickness coupled to a two-stage RF current amplifier. The production of the final detector modules is almost done. A S/N ratio of 10:1 has been achieved with minimum ionizing particles (MIPs) in the test beam setup at KEK. Results from the test beams and bench measurements are presented.

ATLAS diamond Beam Condition Monitor

International Nuclear Information System (INIS)

Gorisek, A.; Cindro, V.; Dolenc, I.; Frais-Koelbl, H.; Griesmayer, E.; Kagan, H.; Korpar, S.; Kramberger, G.; Mandic, I.; Meyer, M.; Mikuz, M.; Pernegger, H.; Smith, S.; Trischuk, W.; Weilhammer, P.; Zavrtanik, M.

2007-01-01

The ATLAS experiment has chosen to use diamond for its Beam Condition Monitor (BCM) given its radiation hardness, low capacitance and short charge collection time. In addition, due to low leakage current diamonds do not require cooling. The ATLAS Beam Condition Monitoring system is based on single beam bunch crossing measurements rather than integrating the accumulated particle flux. Its fast electronics will allow separation of LHC collisions from background events such as beam gas interactions or beam accidents. There will be two stations placed symmetrically about the interaction point along the beam axis at z=+/-183.8cm. Timing of signals from the two stations will provide almost ideal separation of beam-beam interactions and background events. The ATLAS BCM module consists of diamond pad detectors of 1cm 2 area and 500μm thickness coupled to a two-stage RF current amplifier. The production of the final detector modules is almost done. A S/N ratio of 10:1 has been achieved with minimum ionizing particles (MIPs) in the test beam setup at KEK. Results from the test beams and bench measurements are presented

New Peak Finding Algorithm for the BCM1F Detector of the CMS Experiment at CERN

CERN Document Server

Ruede, Alexander Jonas

The Compact Muon Solenoid experiment (CMS) is located at the most powerful particle collider in the world, the Large Hadron Collider (LHC). It detects the resulting prod- ucts of the proton beams that have been accelerated and collide in the center of the experiment. For the operation of a particle collider, a prompt measurement result of the so-called luminosity is of high priority, as it quantifies the ability of the collider to produce a certain number of specific particle interactions. The BCM1F detector is one of the instruments that are installed along the beam pipe to provide an online measure- ment of the luminosity. For reliable results, the electrical pulses that are produced by particle hits at the sensors have to be detected and characterised by their relative arrival time. In the currently operating back end system, the pulses are detected using a single threshold discriminator. This approach shows hit counting inefficiencies, especially for closely occurring, consecutive pulses. A similar puls...

The ATLAS Beam Conditions Monitor

International Nuclear Information System (INIS)

Cindro, V; Dolenc, I; Kramberger, G; Macek, B; Mandic, I; Mikuz', M; Zavrtanik, M; Dobos, D; Gorisek, A; Pernegger, H; Weilhammer, P; Frais-Koelbl, H; Griesmayer, E; Niegl, M; Kagan, H; Tardif, D; Trischuk, W

2008-01-01

Beam conditions and the potential detector damage resulting from their anomalies have pushed the LHC experiments to build their own beam monitoring devices. The ATLAS Beam Conditions Monitor (BCM) consists of two stations (forward and backward) of detectors each with four modules. The sensors are required to tolerate doses up to 500 kGy and in excess of 10 15 charged particles per cm 2 over the lifetime of the experiment. Each module includes two diamond sensors read out in parallel. The stations are located symmetrically around the interaction point, positioning the diamond sensors at z = ±184 cm and r = 55 mm (a pseudo- rapidity of about 4.2). Equipped with fast electronics (2 ns rise time) these stations measure time-of-flight and pulse height to distinguish events resulting from lost beam particles from those normally occurring in proton-proton interactions. The BCM also provides a measurement of bunch-by-bunch luminosities in ATLAS by counting in-time and out-of-time collisions. Eleven detector modules have been fully assembled and tested. Tests performed range from characterisation of diamond sensors to full module tests with electron sources and in proton testbeams. Testbeam results from the CERN SPS show a module median-signal to noise of 11:1 for minimum ionising particles incident at a 45-degree angle. The best eight modules were installed on the ATLAS pixel support frame that was inserted into ATLAS in the summer of 2007. This paper describes the full BCM detector system along with simulation studies being used to develop the logic in the back-end FPGA coincidence hardware

The ATLAS Beam Conditions Monitor

Energy Technology Data Exchange (ETDEWEB)

Cindro, V; Dolenc, I; Kramberger, G; Macek, B; Mandic, I; Mikuz' , M; Zavrtanik, M [Jozef Stefan Institute and Department of Physics, University of Ljubljana, Ljubljana (Slovenia); Dobos, D; Gorisek, A; Pernegger, H; Weilhammer, P [CERN, Geneva (Switzerland); Frais-Koelbl, H; Griesmayer, E; Niegl, M [University of Applied Sciences Wiener Neustadt and Fotec, Wiener Neustadt (Austria); Kagan, H [Ohio State University, Columbus (United States); Tardif, D; Trischuk, W [University of Toronto, Toronto (Canada)], E-mail: william@physics.utoronto.ca

2008-02-15

Beam conditions and the potential detector damage resulting from their anomalies have pushed the LHC experiments to build their own beam monitoring devices. The ATLAS Beam Conditions Monitor (BCM) consists of two stations (forward and backward) of detectors each with four modules. The sensors are required to tolerate doses up to 500 kGy and in excess of 10{sup 15} charged particles per cm{sup 2} over the lifetime of the experiment. Each module includes two diamond sensors read out in parallel. The stations are located symmetrically around the interaction point, positioning the diamond sensors at z = {+-}184 cm and r = 55 mm (a pseudo- rapidity of about 4.2). Equipped with fast electronics (2 ns rise time) these stations measure time-of-flight and pulse height to distinguish events resulting from lost beam particles from those normally occurring in proton-proton interactions. The BCM also provides a measurement of bunch-by-bunch luminosities in ATLAS by counting in-time and out-of-time collisions. Eleven detector modules have been fully assembled and tested. Tests performed range from characterisation of diamond sensors to full module tests with electron sources and in proton testbeams. Testbeam results from the CERN SPS show a module median-signal to noise of 11:1 for minimum ionising particles incident at a 45-degree angle. The best eight modules were installed on the ATLAS pixel support frame that was inserted into ATLAS in the summer of 2007. This paper describes the full BCM detector system along with simulation studies being used to develop the logic in the back-end FPGA coincidence hardware.

Fluid Status in Peritoneal Dialysis Patients: The European Body Composition Monitoring (EuroBCM) Study Cohort

Science.gov (United States)

Van Biesen, Wim; Williams, John D.; Covic, Adrian C.; Fan, Stanley; Claes, Kathleen; Lichodziejewska-Niemierko, Monika; Verger, Christian; Steiger, Jurg; Schoder, Volker; Wabel, Peter; Gauly, Adelheid; Himmele, Rainer

2011-01-01

Background Euvolemia is an important adequacy parameter in peritoneal dialysis (PD) patients. However, accurate tools to evaluate volume status in clinical practice and data on volume status in PD patients as compared to healthy population, and the associated factors, have not been available so far. Methods We used a bio-impedance spectroscopy device, the Body Composition Monitor (BCM) to assess volume status in a cross-sectional cohort of prevalent PD patients in different European countries. The results were compared to an age and gender matched healthy population. Results Only 40% out of 639 patients from 28 centres in 6 countries were normovolemic. Severe fluid overload was present in 25.2%. There was a wide scatter in the relation between blood pressure and volume status. In a multivariate analysis in the subgroup of patients from countries with unrestricted availability of all PD modalities and fluid types, older age, male gender, lower serum albumin, lower BMI, diabetes, higher systolic blood pressure, and use of at least one exchange per day with the highest hypertonic glucose were associated with higher relative tissue hydration. Neither urinary output nor ultrafiltration, PD fluid type or PD modality were retained in the model (total R2 of the model = 0.57). Conclusions The EuroBCM study demonstrates some interesting issues regarding volume status in PD. As in HD patients, hypervolemia is a frequent condition in PD patients and blood pressure can be a misleading clinical tool to evaluate volume status. To monitor fluid balance, not only fluid output but also dietary input should be considered. Close monitoring of volume status, a correct dialysis prescription adapted to the needs of the patient and dietary measures seem to be warranted to avoid hypervolemia. PMID:21390320

Development of Beam Conditions Monitor for the ATLAS experiment

CERN Document Server

Dolenc Kittelmann, Irena; Mikuž, M

2008-01-01

If there is a failure in an element of the accelerator the resulting beam losses could cause damage to the inner tracking devices of the experiments. This thesis presents the work performed during the development phase of a protection system for the ATLAS experiment at the LHC. The Beam Conditions Monitor (BCM) system is a stand-alone system designed to detect early signs of beam instabilities and trigger a beam abort in case of beam failures. It consists of two detector stations positioned at z=±1.84m from the interaction point. Each station comprises four BCM detector modules installed symmetrically around the beam pipe with sensors located at r=55 mm. This structure will allow distinguishing between anomalous events (beam gas and beam halo interactions, beam instabilities) and normal events due to proton-proton interaction by measuring the time-of-flight as well as the signal pulse amplitude from detector modules on the timescale of nanoseconds. Additionally, the BCM system aims to provide a coarse instan...

Comparison of breast cancer mucin (BCM) and CA 15-3 in human breast cancer

NARCIS (Netherlands)

Garcia, M.B.; Blankenstein, M.A.; Wall, E. van der; Nortier, J.W.R.; Schornagel, J.H.; Thijssen, J.H.H.

1990-01-01

The Breast Cancer Mucin (BCM) enzyme immunoassay utilizes two monoclonal antibodies (Mab), M85/34 and F36/22, for the identification of a mucin-like glycoprotein in serum of breast cancer patients. We have compared BCM with CA 15-3, another member of the human mammary epithelial antigen

Planning for and surviving a BCM audit.

Science.gov (United States)

Freestone, Mandy; Lee, Michael

2008-01-01

Business continuity management (BCM) is moving progressively higher up the agendas of boardroom executives due to growing regulator, insurer and investor interest in risk management and BCM activity. With increasing pressure across all sectors, BCM has become an integral part of any effective corporate governance framework. Boardroom executives and senior management are thus now expected to provide an appropriate level of business continuity preparedness to better protect shareholder, investor and other stakeholder interests. The purpose of this paper is to build a link across the 'chasm' that separates the auditee from the auditor. The paper attempts to illuminate understanding about the process undertaken by an auditor when reviewing the BCM process. It details the steps the BCM auditor typically undertakes, and provides practical guidance as to the types of documentation and other supporting evidence required during the process. Additionally, the paper attempts to dispel commonly-held misconceptions about the BCM audit process. Executives, senior management and BCM practitioners will all benefit from the practical guidance offered in this paper, to assist in planning for and surviving a BCM audit.

Commissioning and first operation of the pCVD diamond ATLAS Beam Conditions Monitor

CERN Document Server

Dobos, D

2009-01-01

The main aim of the ATLAS Beam Conditions Monitor is to protect the ATLAS Inner Detector silicon trackers from high radiation doses caused by LHC beam incidents, e.g. magnet failures. The BCM uses in total 16 1x1 cm2 500 μm thick polycrystalline chemical vapor deposition (pCVD) diamond sensors. They are arranged in 8 positions around the ATLAS LHC interaction point. Time difference measurements with sub nanosecond resolution are performed to distinguish between particles from a collision and spray particles from a beam incident. An abundance of the latter leads the BCM to provoke an abort of the LHC beam. A FPGA based readout system with a sampling rate of 2.56 GHz performs the online data analysis and interfaces the results to ATLAS and the beam abort system. The BCM diamond sensors, the detector modules and their readout system are described. Results of the operation with the first LHC beams are reported and results of commissioning and timing measurements (e.g. with cosmic muons) in preparation for first ...

The CMS Fast Beams Condition Monitor Backend Electronics based on MicroTCA technology

CERN Document Server

Zagozdzinska, Agnieszka Anna

2016-01-01

The Fast Beams Condition Monitor (BCM1F), upgraded for LHC Run II, is one sub-system of the Beam Radiation Instrumentation and Luminosity Project of the CMS experiment. It is based on 24 single crystal CVD diamond sensors. Each sensor is metallised with two pads, being read out by a dedicated fast frontend chip produced in 130 nm CMOS technology. Signals for real time monitoring are processed by custom-made back-end electronics to measure separately rates corresponding to LHC collision products, machine induced background and residual activation exploiting different arrival times. The system is built in MicroTCA technology and uses high speed analog-to-digital converters. The data processing module designed for the FPGA allows a distinguishing of collision and machine induced background, both synchronous to the LHC clock, from the residual activation products. In operational modes of high rates, consecutive events, spaced in time by less than 12.5 ns, may partially overlap. Hence, novel signal processing tec...

Luminosity measurement and beam condition monitoring at CMS

Energy Technology Data Exchange (ETDEWEB)

Leonard, Jessica Lynn [DESY, Zeuthen (Germany)

2015-07-01

The BRIL system of CMS consists of instrumentation to measure the luminosity online and offline, and to monitor the LHC beam conditions inside CMS. An accurate luminosity measurement is essential to the CMS physics program, and measurement of the beam background is necessary to ensure safe operation of CMS. In expectation of higher luminosity and denser proton bunch spacing during LHC Run II, many of the BRIL subsystems are being upgraded and others are being added to complement the existing measurements. The beam condition monitor (BCM) consists of several sets of diamond sensors used to measure online luminosity and beam background with a single-bunch-crossing resolution. The BCM also detects when beam conditions become unfavorable for CMS running and may trigger a beam abort to protect the detector. The beam halo monitor (BHM) uses quartz bars to measure the background of the incoming beams at larger radii. The pixel luminosity telescope (PLT) consists of telescopes of silicon sensors designed to provide a CMS online and offline luminosity measurement. In addition, the forward hadronic calorimeter (HF) will deliver an independent luminosity measurement, making the whole system robust and allowing for cross-checks of the systematics. Data from each of the subsystems will be collected and combined in the BRIL DAQ framework, which will publish it to CMS and LHC. The current status of installation and commissioning results for the BRIL subsystems are given.

Run II performance of luminosity and beam condition monitors at CMS

Energy Technology Data Exchange (ETDEWEB)

Leonard, Jessica Lynn [DESY, Hamburg (Germany)

2016-07-01

The BRIL (Beam Radiation Instrumentation and Luminosity) system of CMS consists of instrumentation to measure the luminosity online and offline, and to monitor the LHC beam conditions inside CMS. An accurate luminosity measurement is essential to the CMS physics program, and measurement of the beam background is necessary to ensure safe operation of CMS. Many of the BRIL subsystems have been upgraded and others have been added for LHC Run II to complement the existing measurements. The beam condition monitor (BCM) consists of several sets of diamond sensors used to measure online luminosity and beam background with a single-bunch-crossing resolution. The BCM also detects when beam conditions become unfavorable for CMS running and may trigger a beam abort to protect the detector. The beam halo monitor (BHM) uses quartz bars to measure the background of the incoming beams at larger radii. The pixel luminosity telescope (PLT) consists of telescopes of silicon sensors designed to provide a CMS online and offline luminosity measurement. In addition, the forward hadronic calorimeter (HF) delivers an independent luminosity measurement, making the whole system robust and allowing for cross-checks of the systematics. An overview of the performance during 2015 LHC running for the new/updated BRIL subsystems will be given, including the uncertainties of the luminosity measurements.

Application of diamond based beam loss monitors at LHC

International Nuclear Information System (INIS)

Hempel, Maria

2013-04-01

collimators. Ionization chambers have a time resolution of 40 s that is a half LHC turn and in case of a large beam loss, they request a beam dump. Another type of beam loss monitors are diamond sensors because of a time resolution of about one nanosecond and high radiation hardness. One diamond detector system is located in the cleaning region of the LHC and is able to detect various types of beam losses. Another diamond detector system (BCM1F) is installed inside the CMS detector to protect the CMS from adverse beam conditions. BCM1F monitors also the luminosity during collisions and delivers important beam parameters. Additional condition monitors, based on the BCM1F system, are located next to CMS, near to LHCb and ALICE to measure large beam losses in the LHC ring. The process of a beam loss due to dust particles is explained, and additional simulations were done to understand these process in more detail. The result of the simulation are also given. Beam loss data recorded by the diamond sensors in the cleaning region and the BCM1F diamonds are presented.

Radiation damage in the diamond based beam condition monitors of the CMS experiment at the Large Hadron Collider (LHC) at CERN

CERN Document Server

Guthoff, Moritz; Dabrowski, Anne; De Boer, Wim; Stickland, David; Lange, Wolfgang; Lohmann, Wolfgang

2013-01-01

The Beam Condition Monitor (BCM) of the CMS detector at the LHC is a protection device similar to the LHC Beam Loss Monitor system. While the electronics used is the same, poly-crystalline Chemical Vapor Deposition (pCVD) diamonds are used instead of ionization chambers as the BCM sensor material. The main purpose of the system is the protection of the silicon Pixel and Strip tracking detectors by inducing a beam dump, if the beam losses are too high in the CMS detector. By comparing the detector current with the instantaneous luminosity, the BCM detector ef fi ciency can be monitored. The number of radiation-induced defects in the diamond, reduces the charge collection distance, and hence lowers the signal. The number of these induced defects can be simulated using the FLUKA Monte Carlo simulation. The cross-section for creating defects increases with decreasing energies of the impinging particles. This explains, why diamond sensors mounted close to heavy calorimeters experience more radiation damage, becaus...

Application of diamond based beam loss monitors at LHC

Energy Technology Data Exchange (ETDEWEB)

Hempel, Maria

2013-04-15

the LHC, especially near each quadrupole and next to collimators. Ionization chambers have a time resolution of 40 s that is a half LHC turn and in case of a large beam loss, they request a beam dump. Another type of beam loss monitors are diamond sensors because of a time resolution of about one nanosecond and high radiation hardness. One diamond detector system is located in the cleaning region of the LHC and is able to detect various types of beam losses. Another diamond detector system (BCM1F) is installed inside the CMS detector to protect the CMS from adverse beam conditions. BCM1F monitors also the luminosity during collisions and delivers important beam parameters. Additional condition monitors, based on the BCM1F system, are located next to CMS, near to LHCb and ALICE to measure large beam losses in the LHC ring. The process of a beam loss due to dust particles is explained, and additional simulations were done to understand these process in more detail. The result of the simulation are also given. Beam loss data recorded by the diamond sensors in the cleaning region and the BCM1F diamonds are presented.

Energy consumption and entropy production in a stochastic formulation of BCM learning

International Nuclear Information System (INIS)

De Oliveira, L R; Castellani, G; Turchetti, G

2013-01-01

Biochemical processes in living cells are open systems, therefore they exchange materials with their environment and they consume chemical energy. These processes are molecular-based and for that reason the role of fluctuations can not be ignored and the stochastic description is the most appropriate one. The chemical master equation describes in exact way the probabilistic dynamics of a given discrete set of states and helps us to understand and clarify the differences between closed and open systems. A closed system is related to a condition of detailed balance (DB), i.e. an equilibrium state. After a sufficiently long period, an open system will reach a non-equilibrium steady state (NESS) that is sustained by a flux of external energy. We demonstrate that two implementations of the BCM learning rule (BCM82) and (BCM92) are, respectively, always in DB, and never in DB. We define a one parameter parametrization of the BCM learning rule that interpolates between these two extremes. We compute thermodynamical quantities such as internal energy, free energy (both Helmholtz and Gibbs) and entropy. The entropy variation in the case of open systems (i.e. when DB does not hold) can be divided into internal entropy production and entropy exchanged with surroundings. We show how the entropy variation can be used to find the optimal value (corresponding to increased robustness and stability) for the parameter used in the BCM parametrization. Finally, we use the calculation of the work to drive the system from an initial state to the steady state as the parameter of the plasticity of the system

Evaluation of 18F-labeled exendin(9-39) derivatives targeting glucagon-like peptide-1 receptor for pancreatic β-cell imaging.

Science.gov (United States)

Kimura, Hiroyuki; Ogawa, Yu; Fujimoto, Hiroyuki; Mukai, Eri; Kawashima, Hidekazu; Arimitsu, Kenji; Toyoda, Kentaro; Fujita, Naotaka; Yagi, Yusuke; Hamamatsu, Keita; Murakami, Takaaki; Murakami, Atsushi; Ono, Masahiro; Nakamoto, Yuji; Togashi, Kaori; Inagaki, Nobuya; Saji, Hideo

2018-01-15

β-cell mass (BCM) is known to be decreased in subjects with type-2 diabetes (T2D). Quantitative analysis for BCM would be useful for understanding how T2D progresses and how BCM affects treatment efficacy and for earlier diagnosis of T2D and development of new therapeutic strategies. However, a noninvasive method to measure BCM has not yet been developed. We developed four 18 F-labeled exendin(9-39) derivatives for β-cell imaging by PET: [ 18 F]FB9-Ex(9-39), [ 18 F]FB12-Ex(9-39), [ 18 F]FB27-Ex(9-39), and [ 18 F]FB40-Ex(9-39). Affinity to the glucagon-like peptide-1 receptor (GLP-1R) was evaluated with dispersed islet cells of ddY mice. Uptake of exendin(9-39) derivatives in the pancreas as well as in other organs was evaluated by a biodistribution study. Small-animal PET study was performed after injecting [ 18 F]FB40-Ex(9-39). FB40-Ex(9-39) showed moderate affinity to the GLP-1R. Among all of the derivatives, [ 18 F]FB40-Ex(9-39) resulted in the highest uptake of radioactivity in the pancreas 30 min after injection. Moreover, it showed significantly less radioactivity accumulated in the liver and kidney, resulting in an overall increase in the pancreas-to-organ ratio. In the PET imaging study, pancreas was visualized at 30 min after injection of [ 18 F]FB40-Ex(9-39). [ 18 F]FB40-Ex(9-39) met the basic requirements for an imaging probe for GLP-1R in pancreatic β-cells. Further enhancement of pancreatic uptake and specific binding to GLP-1R will lead to a clear visualization of pancreatic β-cells. Copyright © 2017 Elsevier Ltd. All rights reserved.

Design of BEPCII bunch current monitor system

International Nuclear Information System (INIS)

Zhang Lei; Ma Huizhou; Yue Junhui; Lei Ge; Cao Jianshe; Ma Li

2008-01-01

BEPC II is an electron-positron collider designed to run under multi-bunches and high beam current condition. The accelerator consists of an electron ring, a positron ring and a linear injector. In order to achieve the target luminosity and implement the equal bunch charge injection, the Bunch Current Monitor (BCM) system is built on BEPC II. The BCM system consists of three parts: the front-end circuit, the bunch current acquisition system and the bucket selection system. The control software of BCM is based on VxWorks and EPICS. With the help of BCM system, the bunch current in each bucket can be monitored in the Central Control Room. The BEPC II timing system can also use the bunch current database to decide which bucket needs to refill to implement 'top-off' injection. (authors)

A BCM theory of meta-plasticity for online self-reorganizing fuzzy-associative learning.

Science.gov (United States)

Tan, Javan; Quek, Chai

2010-06-01

Self-organizing neurofuzzy approaches have matured in their online learning of fuzzy-associative structures under time-invariant conditions. To maximize their operative value for online reasoning, these self-sustaining mechanisms must also be able to reorganize fuzzy-associative knowledge in real-time dynamic environments. Hence, it is critical to recognize that they would require self-reorganizational skills to rebuild fluid associative structures when their existing organizations fail to respond well to changing circumstances. In this light, while Hebbian theory (Hebb, 1949) is the basic computational framework for associative learning, it is less attractive for time-variant online learning because it suffers from stability limitations that impedes unlearning. Instead, this paper adopts the Bienenstock-Cooper-Munro (BCM) theory of neurological learning via meta-plasticity principles (Bienenstock et al., 1982) that provides for both online associative and dissociative learning. For almost three decades, BCM theory has been shown to effectively brace physiological evidence of synaptic potentiation (association) and depression (dissociation) into a sound mathematical framework for computational learning. This paper proposes an interpretation of the BCM theory of meta-plasticity for an online self-reorganizing fuzzy-associative learning system to realize online-reasoning capabilities. Experimental findings are twofold: 1) the analysis using S&P-500 stock index illustrated that the self-reorganizing approach could follow the trajectory shifts in the time-variant S&P-500 index for about 60 years, and 2) the benchmark profiles showed that the fuzzy-associative approach yielded comparable results with other fuzzy-precision models with similar online objectives.

PVAMU/XULA/BCM Summer Prostate Cancer Research Program

Science.gov (United States)

2017-10-01

degradation of several cancer -related proteins, including the androgen receptor , which is dysregulated in certain prostate cancers . Overall, the goal of my...Behavior of Androgen Receptor Splice Variants in Androgen Dependent Prostate Cancer Cells Turner, Williamson D., Xavier University of Louisiana, Class...AWARD NUMBER: W81XWH-15-1-0677 TITLE: PVAMU/XULA/BCM Summer Prostate Cancer Research Program PRINCIPAL INVESTIGATOR: Nancy L. Weigel

Long term survey of body composition in hemodialysis patients using the Body Composition Monitor® (BCM

Directory of Open Access Journals (Sweden)

Stanislas Trolonge

2012-06-01

Full Text Available Since 2 years all 265 incident patients in self-dialysis units were included in a prospective study. Every 6-months, clinical and biological nutritional evaluation was associated to a BCM measure. 205 pts have a complete set of data at start (age 60±16 years, BMI 25±5 kg/m2, albumin 37±4 g/L, prealbumin 0.32±0.1 g/L, CRP median 5 mg/L, 135 pts at 6 mo and 56 pts at 2 years. Measures were performed before HD session to ensure stability and reproducibility of body fluid compartments by the same examiner. Lean and fat masses (lean tissue index: LTI, fat tissue index: FTI were normalized by square body height and compared with a reference range derived from 2000 healthy controls, according to gender and age. 28% of pts had values of LTI below the 10th percentile. A linear correlation exists (p<0.001 between pre-dialysis creatinine level and LTI. Albumin or prealbumin were not predictive of sarcopenia. Prescribed post dialysis BW was underestimated in 25% of pts and 16% remain overhydrated. In stable patients repeated measures analysis reveal no significant variation of LTI even in case of reevaluation of BW and gain of BW is associated with fat mass increase. BCM is a simple tool in clinical practice to evaluate body composition and hydratation status and help to guide nutritional support.

Development of a novel diamond based detector for machine induced background and luminosity measurements

International Nuclear Information System (INIS)

Hempel, Maria

2017-07-01

The Large Hadron Collider (LHC) is the largest particle accelerator and storage ring in the world, used to investigate fundamentals of particle physics and to develop at the same time the technology of accelerators and detectors. Four main experiments, located around the LHC ring, provide insight into the nature of particles and search for answers to as yet unexplained phenomena in the universe. These four experiments are ATLAS (A Toroidal LHC Apparatus), ALICE (A Large Ion Collider Experiment), CMS (Compact Muon Solenoid) and LHCb (LHC beauty). Two proton or heavy ion beams circulate in the LHC and are brought into collision in the four experiments. The physics potential of each experiment is determined by the luminosity, which is a ratio of the number of the events during a certain time period to the cross section of a physics process. A measurement of the luminosity is therefore essential to determine the cross section of interesting physics processes. In addition, safe and high-quality data-taking requires stable beam conditions with almost no beam losses. So-called beam loss monitors are installed in the LHC rings to monitor beam losses around the LHC. Each experiment has in addition its own detectors to measure beam losses, hereafter called machine induced background. One such detector is installed in CMS, the Fast Beam Condition Monitor (BCM1F). Based on diamond sensors it was designed and built to measure both, the luminosity and the machine induced background. BCM1F ran smoothly during the first LHC running period from 2009-2012 and delivered valuable beam loss and luminosity information to the control rooms of CMS and LHC. At the end of 2012 the LHC was shut down for an upgrade to improve the performance by increasing the proton energy from 4 TeV to 7 TeV and decreasing the proton bunch spacing from 50 ns to 25 ns. Due to the success of BCM1F an upgrade of its sensors and readout components was planned in order to fulfil the new requirements. The upgrade

Development of a novel diamond based detector for machine induced background and luminosity measurements

Energy Technology Data Exchange (ETDEWEB)

Hempel, Maria

2017-07-15

The Large Hadron Collider (LHC) is the largest particle accelerator and storage ring in the world, used to investigate fundamentals of particle physics and to develop at the same time the technology of accelerators and detectors. Four main experiments, located around the LHC ring, provide insight into the nature of particles and search for answers to as yet unexplained phenomena in the universe. These four experiments are ATLAS (A Toroidal LHC Apparatus), ALICE (A Large Ion Collider Experiment), CMS (Compact Muon Solenoid) and LHCb (LHC beauty). Two proton or heavy ion beams circulate in the LHC and are brought into collision in the four experiments. The physics potential of each experiment is determined by the luminosity, which is a ratio of the number of the events during a certain time period to the cross section of a physics process. A measurement of the luminosity is therefore essential to determine the cross section of interesting physics processes. In addition, safe and high-quality data-taking requires stable beam conditions with almost no beam losses. So-called beam loss monitors are installed in the LHC rings to monitor beam losses around the LHC. Each experiment has in addition its own detectors to measure beam losses, hereafter called machine induced background. One such detector is installed in CMS, the Fast Beam Condition Monitor (BCM1F). Based on diamond sensors it was designed and built to measure both, the luminosity and the machine induced background. BCM1F ran smoothly during the first LHC running period from 2009-2012 and delivered valuable beam loss and luminosity information to the control rooms of CMS and LHC. At the end of 2012 the LHC was shut down for an upgrade to improve the performance by increasing the proton energy from 4 TeV to 7 TeV and decreasing the proton bunch spacing from 50 ns to 25 ns. Due to the success of BCM1F an upgrade of its sensors and readout components was planned in order to fulfil the new requirements. The upgrade

BCM6: New Generation of Boron Meter

International Nuclear Information System (INIS)

Pirat, P.

2010-01-01

Full text of publication follows: Rolls-Royce has developed a new generation of boron meter, based on more than 30 years of experience. The Rolls-Royce BCM6 boron meter provides Nuclear Power Plant (NPP) operators with the boron concentration of the primary circuit. The meter provides continuous and safe measurements with no manual sampling and no human contact. In this paper, technical features, advantages and customer benefits of the use of the new generation of Rolls-Royce BCM6 boron meter will be detailed. Values and associated alarms are provides over different media: 4-20 mA outputs, relays, displays in the main control room and in the chemical lab, and digital links. A special alarm avoids unexpected homogeneous dilution of the primary circuit, which is a critical operational parameter. The Rolls-Royce BCM6 boron meter is fully configurable over a set of parameters allowing adaptation to customer needs. It has a differential capability, thus eliminating neutronic noise and keeping measurements accurate, even in the case of fuel clad rupture. Measurements are accurate, reliable, and have a quick response time. Equipment meets state-of-the-art qualification requests. Designed in 2008, the BCM6 boron meter is the newest equipment of Rolls-Royce boron meters product line. It has been chosen to equip the French EPR NPP and complies with the state-of-the-art of the technology. Rolls-Royce has more than 30 years of experience in Instrumentation and Controls with more than 75 NPP units operating worldwide. All of this experience return has been put in this new generation of equipment to provide the customer with the best operation. About Rolls-Royce Rolls-Royce is a global business providing integrated power systems for use on land, at sea and in the air. The Group has a balanced business portfolio with leading market positions. Rolls-Royce has a broad range of civil nuclear expertise, including work related to licensing and safety reviews, engineering design

Radiation damage in the diamond based beam condition monitors of the CMS experiment at the Large Hadron Collider (LHC) at CERN

Science.gov (United States)

Guthoff, Moritz; Afanaciev, Konstantin; Dabrowski, Anne; de Boer, Wim; Lange, Wolfgang; Lohmann, Wolfgang; Stickland, David

2013-12-01

The Beam Condition Monitor (BCM) of the CMS detector at the LHC is a protection device similar to the LHC Beam Loss Monitor system. While the electronics used is the same, poly-crystalline Chemical Vapor Deposition (pCVD) diamonds are used instead of ionization chambers as the BCM sensor material. The main purpose of the system is the protection of the silicon Pixel and Strip tracking detectors by inducing a beam dump, if the beam losses are too high in the CMS detector. By comparing the detector current with the instantaneous luminosity, the BCM detector efficiency can be monitored. The number of radiation-induced defects in the diamond, reduces the charge collection distance, and hence lowers the signal. The number of these induced defects can be simulated using the FLUKA Monte Carlo simulation. The cross-section for creating defects increases with decreasing energies of the impinging particles. This explains, why diamond sensors mounted close to heavy calorimeters experience more radiation damage, because of the high number of low energy neutrons in these regions. The signal decrease was stronger than expected from the number of simulated defects. Here polarization from trapped charge carriers in the defects is a likely candidate for explaining the difference, as suggested by Transient Current Technique (TCT) measurements. A single-crystalline (sCVD) diamond sensor shows a faster relative signal decrease than a pCVD sensor mounted at the same location. This is expected, since the relative increase in the number of defects is larger in sCVD than in pCVD sensors.

Radiation damage in the diamond based beam condition monitors of the CMS experiment at the Large Hadron Collider (LHC) at CERN

Energy Technology Data Exchange (ETDEWEB)

Guthoff, Moritz, E-mail: moritz.guthoff@cern.ch [CERN, 1211 Genève 23 (Switzerland); Institut für Experimentelle Kernphysik, Karlsruhe Institute of Technology, Campus Süd, P.O. Box 6980, 76128 Karlsruhe (Germany); Afanaciev, Konstantin [DESY, Platanenallee 6, 15738 Zeuthen (Germany); NC PHEP BSU, Minsk (Belarus); Dabrowski, Anne [CERN, 1211 Genève 23 (Switzerland); Boer, Wim de [Institut für Experimentelle Kernphysik, Karlsruhe Institute of Technology, Campus Süd, P.O. Box 6980, 76128 Karlsruhe (Germany); Lange, Wolfgang [DESY, Platanenallee 6, 15738 Zeuthen (Germany); Lohmann, Wolfgang [DESY, Platanenallee 6, 15738 Zeuthen (Germany); Brandenburgische Technische Universität, Postfach 101344, 03013 Cottbus (Germany); Stickland, David [Princeton University, Princeton, NJ 08544-0708 (United States)

2013-12-01

The Beam Condition Monitor (BCM) of the CMS detector at the LHC is a protection device similar to the LHC Beam Loss Monitor system. While the electronics used is the same, poly-crystalline Chemical Vapor Deposition (pCVD) diamonds are used instead of ionization chambers as the BCM sensor material. The main purpose of the system is the protection of the silicon Pixel and Strip tracking detectors by inducing a beam dump, if the beam losses are too high in the CMS detector. By comparing the detector current with the instantaneous luminosity, the BCM detector efficiency can be monitored. The number of radiation-induced defects in the diamond, reduces the charge collection distance, and hence lowers the signal. The number of these induced defects can be simulated using the FLUKA Monte Carlo simulation. The cross-section for creating defects increases with decreasing energies of the impinging particles. This explains, why diamond sensors mounted close to heavy calorimeters experience more radiation damage, because of the high number of low energy neutrons in these regions. The signal decrease was stronger than expected from the number of simulated defects. Here polarization from trapped charge carriers in the defects is a likely candidate for explaining the difference, as suggested by Transient Current Technique (TCT) measurements. A single-crystalline (sCVD) diamond sensor shows a faster relative signal decrease than a pCVD sensor mounted at the same location. This is expected, since the relative increase in the number of defects is larger in sCVD than in pCVD sensors. -- Highlights: •The BCM system and its diamond detectors at the CMS experiment of the LHC are presented. •Detectors show a decreased signal strength with increasing integrated luminosity. •CCD measurements using constant HV and alternating HV to prevent polarization are compared. •TCT measurements show a decreasing signal when polarization builds up. •Polarization effects are a likely

Radiation damage in the diamond based beam condition monitors of the CMS experiment at the Large Hadron Collider (LHC) at CERN

International Nuclear Information System (INIS)

Guthoff, Moritz; Afanaciev, Konstantin; Dabrowski, Anne; Boer, Wim de; Lange, Wolfgang; Lohmann, Wolfgang; Stickland, David

2013-01-01

The Beam Condition Monitor (BCM) of the CMS detector at the LHC is a protection device similar to the LHC Beam Loss Monitor system. While the electronics used is the same, poly-crystalline Chemical Vapor Deposition (pCVD) diamonds are used instead of ionization chambers as the BCM sensor material. The main purpose of the system is the protection of the silicon Pixel and Strip tracking detectors by inducing a beam dump, if the beam losses are too high in the CMS detector. By comparing the detector current with the instantaneous luminosity, the BCM detector efficiency can be monitored. The number of radiation-induced defects in the diamond, reduces the charge collection distance, and hence lowers the signal. The number of these induced defects can be simulated using the FLUKA Monte Carlo simulation. The cross-section for creating defects increases with decreasing energies of the impinging particles. This explains, why diamond sensors mounted close to heavy calorimeters experience more radiation damage, because of the high number of low energy neutrons in these regions. The signal decrease was stronger than expected from the number of simulated defects. Here polarization from trapped charge carriers in the defects is a likely candidate for explaining the difference, as suggested by Transient Current Technique (TCT) measurements. A single-crystalline (sCVD) diamond sensor shows a faster relative signal decrease than a pCVD sensor mounted at the same location. This is expected, since the relative increase in the number of defects is larger in sCVD than in pCVD sensors. -- Highlights: •The BCM system and its diamond detectors at the CMS experiment of the LHC are presented. •Detectors show a decreased signal strength with increasing integrated luminosity. •CCD measurements using constant HV and alternating HV to prevent polarization are compared. •TCT measurements show a decreasing signal when polarization builds up. •Polarization effects are a likely

F1 occurrence including L condition in TUCUMAN and BUENOS AIRES

International Nuclear Information System (INIS)

Mosert Gonzalez, M. de; Ezquer, R.G.; Oviedo, R.V. del

1997-01-01

An analysis of the occurrence of the F1 layer including the L condition has been done, using data from two Argentine stations: TUCUMAN and BUENOS AIRES, at different seasons and solar activity conditions. The comparisons between observations and the F1 occurrence predicted by the IRI-90 model show the need of reviewing the use of the DuCharme et al. (1973) formula adopted by the model to predict the occurrence of the intermediate F1 layer including the L condition. (author). 6 refs, 6 figs, 2 tabs

Nutritional status of children with clinical conditions.

Science.gov (United States)

Murphy, Alexia J; Hill, Rebecca J; Buntain, Helen; White, Melinda; Brookes, Denise; Davies, Peter S W

2017-06-01

Nutritional status is an important consideration in many pediatric clinical conditions. This paper aimed to examine and compare the nutritional status, represented by body cell mass (BCM), of children with cancer, Crohn's disease (CD), cystic fibrosis (CF) and anorexia nervosa (AN). Anthropometry was measured and BCM was calculated from whole body potassium-40 counting in 259 children being treated for clinical conditions (n = 66 cancer; n = 59 AN; n = 75 CF; n = 59 CD) and 108 healthy children. BCM was adjusted for height (BCMI) and expressed as a Z-score relative to laboratory reference data. The CD (-0.80 ± 1.61; p = 0.0001) and AN (-1.13 ± 0.99; p = 0.0001) groups had significantly lower BMI Z-score than the healthy control (0.13 ± 0.75), cancer (0.50 ± 1.40) and CF groups (-0.09 ± 0.95). The cancer (-1.16 ± 1.60; p = 0.0001), CD (-1.13 ± 1.36; p = 0.0001) and AN (-0.97 ± 1.18; p = 0.0001) groups had significantly reduced BCM compared to the healthy control (0.07 ± 0.93) and CF group (0.31 ± 1.08). According to BCMI Z-score, 42.4% of patients with cancer, 41.7% of the patients with CD, 27.1% of patients with AN, and 4.0% of patients with CF were considered malnourished. This study demonstrates that children undergoing treatment for clinical conditions may have alterations in BCM, independent of BMI. Children with cancer, CD and AN all had a high prevalence of malnutrition. Assessment of body composition, not just body size, is vital to understand nutritional status in children with clinical conditions. Copyright © 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Evaluating the capabilities of portable black carbon monitors and photometers for measuring airborne carbon nanotubes

Energy Technology Data Exchange (ETDEWEB)

Hashimoto, Naomi; Ogura, Isamu, E-mail: i-ogura@aist.go.jp; Kotake, Mari; Kishimoto, Atsuo; Honda, Kazumasa [Technology Research Association for Single Wall Carbon Nanotubes (TASC) (Japan)

2013-11-15

For daily monitoring of occupational exposure to aerosolized carbon nanotubes (CNTs) where CNTs are manufactured and handled, inexpensive real-time measuring methods are preferable. In this study, we evaluated the capabilities of a portable black carbon monitor (BCM; also called an aethalometer) and a light-scattering aerosol photometer in detecting airborne CNTs. The responses of these instruments to airborne CNTs, aerosolized through vortex shaking, were evaluated by comparing the measurements of CNT mass concentrations made by these instruments to those determined through thermal carbon analysis. Results showed that their raw readings underestimated CNT mass concentrations in most cases. Their sensitivities depended on the type of CNTs and decreased with the particle sizes of aerosolized CNT clumps. We also found that the sensitivity of the BCM tended to substantially decrease with increasing filter load, even before the point at which the filter should be replaced as recommended by the manufacturer, which could be attributed to a clean environmental condition (i.e., the absence of ubiquitous light-scattering material). As an example of the use of these instruments for measuring airborne CNTs in the presence of background aerosols, a CNT-handling simulation was also conducted. Although both the BCM and the photometer could detect CNT emissions, the BCM was more sensitive to the detection of emitted CNTs in the presence of background aerosols. The correction factors obtained from the response evaluations could enhance the measurement accuracy of these instruments, which will be helpful for the daily monitoring of CNTs at workplaces.

Evaluating the capabilities of portable black carbon monitors and photometers for measuring airborne carbon nanotubes

International Nuclear Information System (INIS)

Hashimoto, Naomi; Ogura, Isamu; Kotake, Mari; Kishimoto, Atsuo; Honda, Kazumasa

2013-01-01

For daily monitoring of occupational exposure to aerosolized carbon nanotubes (CNTs) where CNTs are manufactured and handled, inexpensive real-time measuring methods are preferable. In this study, we evaluated the capabilities of a portable black carbon monitor (BCM; also called an aethalometer) and a light-scattering aerosol photometer in detecting airborne CNTs. The responses of these instruments to airborne CNTs, aerosolized through vortex shaking, were evaluated by comparing the measurements of CNT mass concentrations made by these instruments to those determined through thermal carbon analysis. Results showed that their raw readings underestimated CNT mass concentrations in most cases. Their sensitivities depended on the type of CNTs and decreased with the particle sizes of aerosolized CNT clumps. We also found that the sensitivity of the BCM tended to substantially decrease with increasing filter load, even before the point at which the filter should be replaced as recommended by the manufacturer, which could be attributed to a clean environmental condition (i.e., the absence of ubiquitous light-scattering material). As an example of the use of these instruments for measuring airborne CNTs in the presence of background aerosols, a CNT-handling simulation was also conducted. Although both the BCM and the photometer could detect CNT emissions, the BCM was more sensitive to the detection of emitted CNTs in the presence of background aerosols. The correction factors obtained from the response evaluations could enhance the measurement accuracy of these instruments, which will be helpful for the daily monitoring of CNTs at workplaces

78 FR 9446 - Advance Nanotech, Inc., Advanced ID Corp., Aeon Holdings, Inc. (n/k/a BCM Energy Partners, Inc...

Science.gov (United States)

2013-02-08

... SECURITIES AND EXCHANGE COMMISSION [File No. 500-1] Advance Nanotech, Inc., Advanced ID Corp., Aeon Holdings, Inc. (n/k/a BCM Energy Partners, Inc.), ANTS Software, Inc., Beauty Brands Group, Inc... current and accurate information concerning the securities of Advanced Nanotech, Inc. because it has not...

Blood volume-monitored regulation of ultrafiltration in fluid-overloaded hemodialysis patients: study protocol for a randomized controlled trial

Directory of Open Access Journals (Sweden)

Hecking Manfred

2012-06-01

Full Text Available Abstract Background Data generated with the body composition monitor (BCM, Fresenius show, based on bioimpedance technology, that chronic fluid overload in hemodialysis patients is associated with poor survival. However, removing excess fluid by lowering dry weight can be accompanied by intradialytic and postdialytic complications. Here, we aim at testing the hypothesis that, in comparison to conventional hemodialysis, blood volume-monitored regulation of ultrafiltration and dialysate conductivity (UCR and/or regulation of ultrafiltration and temperature (UTR will decrease complications when ultrafiltration volumes are systematically increased in fluid-overloaded hemodialysis patients. Methods/design BCM measurements yield results on fluid overload (in liters, relative to extracellular water (ECW. In this prospective, multicenter, triple-arm, parallel-group, crossover, randomized, controlled clinical trial, we use BCM measurements, routinely introduced in our three maintenance hemodialysis centers shortly prior to the start of the study, to recruit sixty hemodialysis patients with fluid overload (defined as ≥15% ECW. Patients are randomized 1:1:1 into UCR, UTR and conventional hemodialysis groups. BCM-determined, ‘final’ dry weight is set to normohydration weight −7% of ECW postdialysis, and reached by reducing the previous dry weight, in steps of 0.1 kg per 10 kg body weight, during 12 hemodialysis sessions (one study phase. In case of intradialytic complications, dry weight reduction is decreased, according to a prespecified algorithm. A comparison of intra- and post-dialytic complications among study groups constitutes the primary endpoint. In addition, we will assess relative weight reduction, changes in residual renal function, quality of life measures, and predialysis levels of various laboratory parameters including C-reactive protein, troponin T, and N-terminal pro-B-type natriuretic peptide, before and after the first study

Assessment of Augmented Electronic Fuel Controls for Modular Engine Diagnostics and Condition Monitoring

Science.gov (United States)

1978-12-01

removal of the horoscope . Diagnostic Conoctor - E4 Th10 E4 23-pin connoctor on the electrical control unit Is provided for ground- checking electrical...confidenou in engine condition monitoring * 1min general. Thi9 has boon especially true in~ eases where fUse signal s have c~aused engine shutdowns. Where ECWI

Predictive value of [18F]-fluoride PET for monitoring bone remodeling in patients with orthopedic conditions treated with a Taylor spatial frame.

Science.gov (United States)

Sanchez-Crespo, Alejandro; Christiansson, Frederik; Thur, Charlotte Karlsson; Lundblad, Henrik; Sundin, Anders

2017-03-01

The Taylor Spatial Frame (TSF) is used to correct orthopedic conditions such as correction osteotomies in delayed fracture healing and pseudarthrosis. Long-term TSF-treatments are common and may lead to complications. Current conventional radiological methods are often unsatisfactory for therapy monitoring. Hence, an imaging technique capable of quantifying bone healing progression would be advantageous. A cohort of 24 patients with different orthopedic conditions, pseudarthrosis (n = 10), deformities subjected to correction osteotomy (n = 9), and fracture (n = 5) underwent dynamic [ 18 F]-fluoride (Na 18 F) PET/CT at 8 weeks and 4 months, respectively, after application of a TSF. Parametric images, corresponding to the net transport rate of [ 18 F]-fluoride from plasma to bone, K i were calculated. The ratio of the maximum K i at PET scan 2 and 1 ([Formula: see text]) as well as the ratio of the maximum Standard Uptake Value at PET scan 2 and 1 ([Formula: see text]) were calculated for each individual. Different treatment end-points were scored, and the overall treatment outcome score was compared with the osteoblastic activity progression as scored with [Formula: see text] or [Formula: see text]. [Formula: see text] and [Formula: see text] were not correlated within each orthopedic group (p > 0.1 for all groups), nor for the pooled population (p = 0.12). The distribution of [Formula: see text] was found significantly different among the different orthopedic groups (p = 0.0046) -also for [Formula: see text] (p = 0.022). The positive and negative treatment predictive values for [Formula: see text] were 66.7 % and 77.8 %, respectively. Corresponding values for [Formula: see text] were 25 % and 33.3 % CONCLUSIONS: The [Formula: see text] obtained from dynamic [ 18 F]-fluoride-PET imaging is a promising predictive factor to evaluate changes in bone healing in response to TSF treatment.

Predictive value of [{sup 18}F]-fluoride PET for monitoring bone remodeling in patients with orthopedic conditions treated with a Taylor spatial frame

Energy Technology Data Exchange (ETDEWEB)

Sanchez-Crespo, Alejandro [Karolinska University Hospital, Department of Hospital Physics, Nuclear Medicine, Stockholm (Sweden); Karolinska University Hospital, Stockholm (Sweden); Christiansson, Frederik [Nykoepings Hospital, Department of Radiology, Nykoeping (Sweden); Karlsson Thur, Charlotte; Lundblad, Henrik [Karolinska Institutet, Department of Molecular Medicine and Surgery, Stockholm (Sweden); Sundin, Anders [Uppsala University Hospital, Department of Radiology and Molecular Imaging, Uppsala (Sweden)

2017-03-15

The Taylor Spatial Frame (TSF) is used to correct orthopedic conditions such as correction osteotomies in delayed fracture healing and pseudarthrosis. Long-term TSF-treatments are common and may lead to complications. Current conventional radiological methods are often unsatisfactory for therapy monitoring. Hence, an imaging technique capable of quantifying bone healing progression would be advantageous. A cohort of 24 patients with different orthopedic conditions, pseudarthrosis (n = 10), deformities subjected to correction osteotomy (n = 9), and fracture (n = 5) underwent dynamic [{sup 18}F]-fluoride (Na{sup 18}F) PET/CT at 8 weeks and 4 months, respectively, after application of a TSF. Parametric images, corresponding to the net transport rate of [{sup 18}F]-fluoride from plasma to bone, K{sub i} were calculated. The ratio of the maximum K{sub i} at PET scan 2 and 1 (anti K{sub i,max}) as well as the ratio of the maximum Standard Uptake Value at PET scan 2 and 1 (SUV {sub max}) were calculated for each individual. Different treatment end-points were scored, and the overall treatment outcome score was compared with the osteoblastic activity progression as scored with anti K{sub i,max} or SUV {sub max}. anti K{sub i,max} and SUV {sub max} were not correlated within each orthopedic group (p > 0.1 for all groups), nor for the pooled population (p = 0.12). The distribution of anti K{sub i,max} was found significantly different among the different orthopedic groups (p = 0.0046) - also for SUV {sub max} (p = 0.022). The positive and negative treatment predictive values for anti K{sub i,max} were 66.7 % and 77.8 %, respectively. Corresponding values for SUV {sub max} were 25 % and 33.3 % The anti K{sub i,max} obtained from dynamic [{sup 18}F]-fluoride-PET imaging is a promising predictive factor to evaluate changes in bone healing in response to TSF treatment. (orig.)

Michael Niegl (1985-2009)

CERN Multimedia

2009-01-01

Our friend and colleague Michael Niegl died in a tragic accident in the first hours of the new year. Michael was a Master’s student in Microsystems Engineering at the University of Applied Sciences Wiener Neustadt. He was responsible for the development of the ATLAS Beam Conditions Monitor (BCM) ROD FPGA firmware, which acquires the data from the BCM detector modules and provides online monitoring of the LHC beams within the ATLAS experiment. He spent several months at CERN to carry out beam tests on the BCM detectors and received his Bachelor of Science with first class honours for his thesis: Concept and Implementation of an FPGA-based Data Recorder and Processor for the ATLAS Beam Conditions Monitor. Michael spent six months at CERN last year to finish the development and commissioning of the ROD firmware for the first beam. He worked the entire night of 10 September to fine tune the system for the first beam. It was a joy to ...

Performance of F1 Primiparous German Black-headed Mutton x Turcana Crossbred Ewes under Extensive Management Conditions

Directory of Open Access Journals (Sweden)

Dinu Gavojdian

2012-10-01

Full Text Available Aim of the current research was to evaluate the effects that crossbreeding Romanian indigenous Turcana (TA eweswith German Black-faced Mutton (GBM rams have on the body weight and reproduction performances ofprimiparous F1 GBM x TA descendants under extensive management conditions, when put to ram as ewe lambs or asyearlings. The study was initiated in a commercial farm from Timis County, western Romania, and starting autumn2009. At the age of 8 months, F1 crossbred female lambs registered on average 37.6 kg, while averages og 32.2 kgwere achieved by the TA females from the control group (CG, differences between the two genotypes weresignificant (p<0.001. When put to ram as ewe-lambs at the age of 8 months, F1 crossbreds registered a averagefertility rate of 84.0%, compared with 29.4% the females from the CG, differences registered between the two groupswere significant (p<0.01. Data registered in the current study proven that the F1 crossbreds are significantly moreprecocious compared to purebred TA, reared under identical conditions. When put to ram at the age of 18 months,F1crossbred glimmers registered an average prolificacy of 140.0%, compared to 111.7% the females from the CG.GBM sired females grow faster, achieve higher body weights, are more precocious and more prolific compared withpurebred TA females of the same age.

Condition monitoring of PARR-1 rotating machines by vibration analysis technique

Directory of Open Access Journals (Sweden)

Qadir Javed

2014-01-01

Full Text Available Vibration analysis is a key tool for preventive maintenance involving the trending and analysis of machinery performance parameters to detect and identify developing problems before failure and extensive damage can occur. A lab-based experimental setup has been established for obtaining fault-free and fault condition data. After this analysis, primary and secondary motor and pump vibration data of the Pakistan Research Reactor-1 were obtained and analyzed. Vibration signatures were acquired in horizontal, vertical, and axial directions. The 48 vibration signatures have been analyzed to assess the operational status of motors and pumps. The vibration spectrum has been recorded for a 2000 Hz frequency span with a 3200 lines resolution. The data collected should be helpful in future Pakistan Research Reactor-1 condition monitoring.

Verification of alternatives for sustainable onion production (Allium cepa L. in Cucaita, Boyaca

Directory of Open Access Journals (Sweden)

Viteri R. Silvio Edgar

2012-04-01

Full Text Available

In Cucaita, onion production represents the basis of the economy and is concentrated in the valley but as yield declines due to deterioration of the soil, cultivation is shifting to the slopes, where unsustainability is more prominent. The aim of this study was to verify the potential of three alternatives for sustainable farming, using a split plot design on two farms. The alternatives were: 1 bocashi chicken manure, super broth four, fertilizer (BCmSB4F, 2 bocashi cow manure, rhizosphere broth, super broth four, fertilizer (BCmRBSB4F, 3 green manure, rhizosphere broth, super broth four, fertilizer (Gm- RBSB4F and 4 regional control (RC. This study determined disease incidence, plant height, stem and bulb diameter, healthy and diseased bulb weight and yield. The results indicated that regardless of the alternative, the agro-ecological conditions of the farm are critical to plant health and consequently to crop production. In El Arenal, where disease incidence was lower, the highest values for healthy bulb weight, bulb diameter and yield were revealed. The alternatives only differed in disease incidence at 30 and 45 days after transplant, with the lowest percentages corresponding to the green manure alternative. For revenue, the three alternatives were favorable, especially the BCmRBSB4F alternative which exceeded the RC. The results show that the alternatives GmRBSB4F and BCmRBSB4F have the most potential and are the most viable for sustainable onion production in Cucaita, Boyaca.

F-Area Hazardous Waste Management Facility groundwater monitoring report, Third and fourth quarters 1995: Volume 1

International Nuclear Information System (INIS)

1996-03-01

Groundwater at the F-Area Hazardous Waste Management Facility (HWMF) is monitored in compliance with applicable regulations. Monitoring results are compared to the South Carolina Department of Health and Environmental Control (SCDHEC) Groundwater Protection Standard (GWPS). Historically and currently, gross alpha, nitrates, nonvolatile beta, and tritium are among the primary constituents to exceed standards. Numerous other radionuclides and hazardous constituents also exceed the GWPS in the groundwater during the second half of 1995, notably cadmium, lead, radium-226, radium-228, strontium-90, and total alpha-emitting radium. The elevated constituents were found primarily in the water table (aquifer zone IIB 2 ), however, several other aquifer unit monitoring wells contained elevated levels of constituents. Water-level maps indicate that the groundwater flow rates and directions at the F-Area HWMF have remained relatively constant since the basins ceased to be active in 1988

BCM-95 and (2-hydroxypropyl)-β-cyclodextrin reverse autophagy dysfunction and deplete stored lipids in Sap C-deficient fibroblasts.

Science.gov (United States)

Tatti, Massimo; Motta, Marialetizia; Scarpa, Susanna; Di Bartolomeo, Sabrina; Cianfanelli, Valentina; Tartaglia, Marco; Salvioli, Rosa

2015-08-01

Saposin (Sap) C deficiency is a rare variant form of Gaucher disease caused by impaired Sap C expression or accelerated degradation, and associated with accumulation of glucosylceramide and other lipids in the endo/lysosomal compartment. No effective therapies are currently available for the treatment of Sap C deficiency. We previously reported that a reduced amount and enzymatic activity of cathepsin (Cath) B and Cath D, and defective autophagy occur in Sap C-deficient fibroblasts. Here, we explored the use of two compounds, BCM-95, a curcumin derivative, and (2-hydroxypropyl)-β-cyclodextrin (HP-β-CD), to improve lysosomal function of Sap C-deficient fibroblasts. Immunofluorescence and biochemical studies documented that each compound promotes an increase of the expression levels and activities of Cath B and Cath D, and efficient clearance of cholesterol (Chol) and ceramide (Cer) in lysosomes. We provide evidence that BCM-95 and HP-β-CD enhance lysosomal function promoting autophagic clearance capacity and lysosome reformation. Our findings suggest a novel pharmacological approach to Sap C deficiency directed to treat major secondary pathological aspects in this disorder. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Comprehensive studies on irradiated single-crystal diamond sensors

Energy Technology Data Exchange (ETDEWEB)

Stegler, Martin [DESY, Zeuthen (Germany)

2015-07-01

Single-crystal diamond sensors are used as part of the Beam and Radiation Instrumentation and Luminosity (BRIL) projects of the CMS experiment. Due to an upgrade of the Fast Beam Conditions Monitor (BCM1F) these diamond sensors are exchanged and the irradiated ones are now used for comprehensive studies. Current over voltage (IV), current over time (CT) and charge collection efficiency (CCE) measurements were performed for a better understanding of the radiation damage incurred during operation and to compensate in the future. The effect of illumination with various light sources on the charge collection efficiency was investigated and led to interesting results. Intensity and wavelength of the light were varied for deeper insight of polarization effects.

Environmental monitoring and research at the John F. Kennedy Space Center

Science.gov (United States)

Hall, C. R.; Hinkle, C. R.; Knott, W. M.; Summerfield, B. R.

1992-01-01

The Biomedical Operations and Research Office at the NASA John F. Kennedy Space Center has been supporting environmental monitoring and research since the mid-1970s. Program elements include monitoring of baseline conditions to document natural variability in the ecosystem, assessments of operations and construction of new facilities, and ecological research focusing on wildlife habitat associations. Information management is centered around development of a computerized geographic information system that incorporates remote sensing and digital image processing technologies along with traditional relational data base management capabilities. The proactive program is one in which the initiative is to anticipate potential environmental concerns before they occur and, by utilizing in-house expertise, develop impact minimization or mitigation strategies to reduce environmental risk.

Wind Turbine Drivetrain Condition Monitoring During GRC Phase 1 and Phase 2 Testing

Energy Technology Data Exchange (ETDEWEB)

Sheng, S.; Link, H.; LaCava, W.; van Dam, J.; McNiff, B.; Veers, P.; Keller, J.; Butterfield, S.; Oyague, F.

2011-10-01

This report will present the wind turbine drivetrain condition monitoring (CM) research conducted under the phase 1 and phase 2 Gearbox Reliability Collaborative (GRC) tests. The rationale and approach for this drivetrain CM research, investigated CM systems, test configuration and results, and a discussion on challenges in wind turbine drivetrain CM and future research and development areas, will be presented.

Synthesis and evaluation of [18F]exendin (9–39) as a potential biomarker to measure pancreatic β-cell mass

International Nuclear Information System (INIS)

Wang Yi; Lim, Keunpoong; Normandin, Marc; Zhao Xiaojian; Cline, Gary W.; Ding Yushin

2012-01-01

Introduction: Glucagon-like peptide 1 (GLP-1) is released in response to food intake and plays an important role in maintaining blood glucose homeostasis. Exendin (9–39), a potent glucagon-like peptide 1 receptor antagonist, has been labeled with In-111 for SPECT imaging. We report here the first radiosynthesis of [ 18 F]exendin (9–39) ([ 18 F]Ex(9–39)) and an evaluation of its potential as a biomarker for in vivo positron emission tomography (PET) imaging of pancreatic β-cell mass (BCM) in rats. Methods: F-18 label was introduced by conjugation of [ 18 F]4-fluorobenzaldehyde with an Ex(9–39) derivative containing a 6-hydrazinonicotinyl group on the ε-amine of Lys27. Positron emission tomography imaging was carried out in Sprague–Dawley rats (five control and five streptozotocin-induced diabetic) and BioBreeding diabetes-prone rats (three at 7 weeks and three at 12 weeks) using the high-resolution research tomograph (HRRT) after 0.187±0.084 mCi [ 18 F]Ex(9–39) administration. Time–activity curves were obtained from pancreas, liver and kidney. Pancreases were assayed for insulin content after the imaging study. Results: Site-specifically labeled [ 18 F]Ex(9–39) was purified on a G15 open column with radiochemical and chemical purities >98%. Positron emission tomography imaging showed pancreatic standardized uptake value (SUV) peaked at 10 min and plateaued by 50 min to the end of scan (240 min). No correlations of pancreatic SUV with postmortem measures of insulin content were seen. Conclusions: [ 18 F]Ex(9–39) was successfully prepared and used for PET imaging for the first time to measure pancreatic BCM. The results suggest that derivatization of the Lys27 residue might reduce binding affinity, as evidenced by the absence of specific binding. Exendin analogues radiolabeled at other sites may elucidate the active site required for binding.

A simple condition monitoring model for a direct monitoring process

NARCIS (Netherlands)

Christer, A.H.; Wang, Wenbin

1995-01-01

This paper addresses the problem of condition monitoring of a component which has available a measure of condition called wear. Wear accumulates over time and monitoring inspections are performed at chosen times to monitor and measure the cumulative wear. If past measurements of wear are available

Condition Monitoring of Cables Task 3 Report: Condition Monitoring Techniques for Electric Cables

Energy Technology Data Exchange (ETDEWEB)

Villaran, M.; Lofaro, R.; na

2009-11-30

For more than 20 years the NRC has sponsored research studying electric cable aging degradation, condition monitoring, and environmental qualification testing practices for electric cables used in nuclear power plants. This report summarizes several of the most effective and commonly used condition monitoring techniques available to detect damage and measure the extent of degradation in electric cable insulation. The technical basis for each technique is summarized, along with its application, trendability of test data, ease of performing the technique, advantages and limitations, and the usefulness of the test results to characterize and assess the condition of electric cables.

Development of condition monitoring and diagnosis system for standby diesel generator

Energy Technology Data Exchange (ETDEWEB)

Choi, Kwang Hee; Park, Jong Hyuck; Park, Jong Eun [Korea Electric Power Research Institute, Daejeon (Korea, Republic of)

2009-05-15

The emergency diesel generator (EDG) of the nuclear power plant is designed to supply the power to the nuclear on Station Black Out (SBO) condition. The operation reliability of onsite emergency diesel generator should be ensured by a condition monitoring system designed to monitor and analysis the condition of diesel generator. For this purpose, we have developed the online condition monitoring and diagnosis system for the wolsong unit 3 and 4 standby diesel generator including diesel engine performance. In this paper, technologies of condition monitoring and diagnosis system (SDG MDS) for the wolsong standby diesel generator are described. By using the condition monitoring module of the SDG MDS, performance monitoring function for major operating parameters of EDG reliability program required by Reg. guide 1.155 can be operated as on line monitoring system.

Development of condition monitoring and diagnosis system for standby diesel generator

International Nuclear Information System (INIS)

Choi, Kwang Hee; Park, Jong Hyuck; Park, Jong Eun

2009-01-01

The emergency diesel generator (EDG) of the nuclear power plant is designed to supply the power to the nuclear on Station Black Out (SBO) condition. The operation reliability of onsite emergency diesel generator should be ensured by a condition monitoring system designed to monitor and analysis the condition of diesel generator. For this purpose, we have developed the online condition monitoring and diagnosis system for the wolsong unit 3 and 4 standby diesel generator including diesel engine performance. In this paper, technologies of condition monitoring and diagnosis system (SDG MDS) for the wolsong standby diesel generator are described. By using the condition monitoring module of the SDG MDS, performance monitoring function for major operating parameters of EDG reliability program required by Reg. guide 1.155 can be operated as on line monitoring system

Development of a Novel Separase Inhibitor, Sepin 1, for Breast Cancer Therapy

Science.gov (United States)

2016-06-01

biomolecular screening 2014, 19 (6), 878‐889.  6. Boiani, M.; Boiani, L.; Denicola, A.; Torres de Ortiz, S.;  Serna,  E .;  Vera   de  Bilbao,  N... E -Mail: pati@bcm.edu 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER Baylor College...clarification regarding this report arise, please contact me at 832-824-4575 or by E -Mail: pati@bcm.tmc.edu. or Fax: 832-825-4651. Yours sincerely

{sup 18}F-F.D.G. PET for staging and monitoring of solitary plasmocytomas;La TEP au {sup 18}F-FDG dans le diagnostic et le suivi evolutif des plasmocytomes solitaires

Energy Technology Data Exchange (ETDEWEB)

Adib, S.; Robua, D.; Huglo, D.; Steinling, M. [CHU de Lille, rue Michel-Polonovski, Service de medecine nucleaire, hopital Claude-Huriez, 59 - Lille (France); Robua, D.; Leleu, X. [CHU de Lille, rue Michel-Polonovski, Service des maladies du sang, hopital Claude-Huriez, 59 - Lille (France)

2010-02-15

Aim: To assess the role of [{sup 18}F]F.D.G.-PET in solitary plasmocytomas with regards to staging, therapeutic follow-up and monitoring. Patients and methods. Twenty consecutive patients were included in the present study when following conditions were met: (1) solitary plasmocytomas histologically confirmed (bone, n = 16; extramedullary, n = 4); (2) [{sup 18}F]F.D.G.-PET scan from July 2004 to April 2009. The clinical follow-up was over than 2 years for 13 patients. Ten patients underwent a post-therapy PET scan. PET scans were visually analysed. Results. PET scan enabled confirmation of all main lesions (sensitivity: 100%) and also detected infra-clinical lesions in eight cases. Follow-up for more than 2 years showed a progression disease into myeloma in five from six cases (83%) with infra clinical lesions at the baseline PET scan. Among 10 patients who underwent post-therapeutic PET scan, six experienced a complete response at the main lesion site and four experienced a partial response. Conclusion: F.D.G.-PET may play an important role in plasmocytomas staging and enables detection of smaller lesions (otherwise undetected). (authors)

Monitoring transient elastic energy storage within the rotary motors of single FoF1-ATP synthase by DCO-ALEX FRET

Science.gov (United States)

Ernst, Stefan; Düser, Monika G.; Zarrabi, Nawid; Börsch, Michael

2012-03-01

The enzyme FoF1-ATP synthase provides the 'chemical energy currency' adenosine triphosphate (ATP) for living cells. Catalysis is driven by mechanochemical coupling of subunit rotation within the enzyme with conformational changes in the three ATP binding sites. Proton translocation through the membrane-bound Fo part of ATP synthase powers a 10-step rotary motion of the ring of c subunits. This rotation is transmitted to the γ and ɛ subunits of the F1 part. Because γ and ɛ subunits rotate in 120° steps, we aim to unravel this symmetry mismatch by real time monitoring subunit rotation using single-molecule Förster resonance energy transfer (FRET). One fluorophore is attached specifically to the F1 motor, another one to the Fo motor of the liposome-reconstituted enzyme. Photophysical artifacts due to spectral fluctuations of the single fluorophores are minimized by a previously developed duty cycle-optimized alternating laser excitation scheme (DCO-ALEX). We report the detection of reversible elastic deformations between the rotor parts of Fo and F1 and estimate the maximum angular displacement during the load-free rotation using Monte Carlo simulations.

Maintenance cost avoidance through comprehensive condition monitoring

International Nuclear Information System (INIS)

Miller, G.P.; McClymonds, S.L.

1990-01-01

Condition monitoring, the measurement and trending of a critical parameter for predictive maintenance, has reached new levels of acceptance and application within the utility and manufacturing industry. Commercially available systems extend well beyond traditional vibration-monitoring systems to include such areas as online wear, crack and leak detection, and stress monitoring. The challenge facing industry is to integrate the information generated from condition monitoring. Current studies indicate that the effectiveness of predictive maintenance depends much more on the program that is established to apply the monitoring techniques than on the monitoring equipment itself. This paper presents a five-phase approach to developing a condition monitoring program

PARTICULARITIES OF WHITE HEAD CABBAGE F1 HYBRID BREEDING FOR PRIDNESTROVIAN MOLDAVIAN REPUBLIC CONDITIONS

Directory of Open Access Journals (Sweden)

L. I. Shpak

2016-01-01

Full Text Available A model of late maturing F1 hybrid of white head cabbage for long-term storing and suitable for national recipe “golubci” have been developed based on requirements for varieties and F1 hybrids grown in the South in the conditions of drought, high temperatures and low air humidity. Combining ability of seven self-incompatible inbred lines of white head cabbage was studied by the system of full diallel crosses in conditions of Pridnestrovian Moldavian Republic. These lines were developed on the base of heat tolerant varieties ‘Biruchekutskaya’, ‘Volna’, ‘Lada’, ‘Moldavanka’ and ‘Kharkovskaya Zimnyaya’ bred in the south. Out of 42 hybrid combinations studied 15 significantly surpassed in productivity the variety ‘Zavadovskaya’ that is traditionally grown by local farmers for pickling and recipe “golubci”. High GCA effects for productivity showed the following breeding lines: Bu1, Ml3 and Kl5. Polygenes, controlling the high yield ability, mainly were dominant and single-directed, however the correlation betweenyield ability and GCA effect was middle, r=0.63±0.35. No correlation was observed inbreeding line between GCA effect and truly heterosis effect in hybrid combinations (r=0.19. Disease resistance analysis revealed lines Bu1 and Kl5 that had shown resistance to Fusarium yellows. Two hybrid combination Kl5xBu1 and Ml3xBu1 were highly tolerant to thrips attacks according to analysis of all promising hybrid combinations, carried out in natural infection background. Weak correlation was observed between the number of damaged leaves in cabbage head and dry matter content, r=0.41±0.21, and also there is no correlation revealed with sugar contents, ascorbic acid and nitrate content. High tolerance of hybrids with participation of line Bu1 explained the partial dominance nature of the trait. Hybrid combinations Kl5xBu1 and Ml3xBu1 called ‘Batal’ and ‘Shedevr’, respectively, included in registry of Moldova and

Condition Indicators for Gearbox Condition Monitoring Systems

Directory of Open Access Journals (Sweden)

P. Večeř

2005-01-01

Full Text Available Condition monitoring systems for manual transmissions based on vibration diagnostics are widely applied in industry. The systems deal with various condition indicators, most of which are focused on a specific type of gearbox fault. Frequently used condition indicators (CIs are described in this paper. The ability of a selected condition indicator to describe the degree of gearing wear was tested using vibration signals acquired during durability testing of manual transmission with helical gears. 

Application of the CaF2(Eu) scintillator to 85Kr monitoring in atmospheric air samples

International Nuclear Information System (INIS)

Wilhelmova, Ludmila; Dvorak, Zdenek; Tomasek, Milan; Stukheil, Karel

1986-01-01

A detection system with a CaF 2 (Eu) scintillator has been developed for monitoring β-radiation of 85 Kr in atmospheric air samples. The geometry of the detector chamber was optimized to achieve maximum detection efficiency. The design of the detector is described and values of the detection efficiency are presented for various compositions and pressures of the gaseous samples. The conditions for calibration of the detector used for monitoring of 85 Kr in enriched air samples have been established. (author)

Exposure rate measurements on TV monitors LiF:Mg, Cu, P (GR- 200A) chips

International Nuclear Information System (INIS)

Sanaye, S.S.; Sadagopan, Geetha; Bhatt, B.C.

2004-01-01

For measuring exposure rate on black and white TV monitor screen, LiF:Mg,Cu,P (GR-200A) TLD chips were used. The samples were kept on TV monitor screen and exposed for 560 hrs with TV in 'ON' condition. The exposure rate on TV monitor screen was determined from integrated TL measurements and it varied from 0.081μGy/hr to 0.106 μGy/hr. Thus it was observed that the exposure levels were well below the prescribed limits (i.e. 5 μGy/h at 5 cm from the surface). LiF:Mg,Cu,P (GR-200A) TLD discs were also used to estimate the dose level on the surface of two types of TV monitors. The samples were kept at five different locations on the two (14 C PT AND 20 C PT) models of TV monitors and exposed for 622 hrs. From the measurement of TL, integrated dose on the screen were in the range 3.86 mR to 12.34 mR, the corresponding dose rate being 6.206 mR/hr to 19.839 mR/hr. This ensures that doses were well below the recommended limit of 0.5 mR/hr at 5cm. (author)

The metabolism of 2-trifluormethylaniline and its acetanilide in the rat by 19F NMR monitored enzyme hydrolysis and 1H/19F HPLC-NMR spectroscopy.

Science.gov (United States)

Tugnait, M; Lenz, E M; Hofmann, M; Spraul, M; Wilson, I D; Lindon, J C; Nicholson, J K

2003-01-01

The urinary excretion profile and identity of the metabolites of 2-trifluoromethyl aniline (2-TFMA) and 2-trifluoromethyl acetanilide (2-TFMAc), following i.p. administration to the rat at 50 mg kg(-1), were determined using a combination of 19F NMR monitored enzyme hydrolysis, SPEC-MS and 19F/1H HPLC-NMR. A total recovery of approximately 96.4% of the dose was excreted into the urine as seven metabolites. The major routes of metabolism were N-conjugation (glucuronidation), and ring-hydroxylation followed by sulphation (and to a lesser extent glucuronidation). The major metabolites excreted into the urine for both compounds were a labile N-conjugated metabolite (a postulated N-glucuronide) and a sulphated ring-hydroxylated metabolite (a postulated 4-amino-5-trifluoromethylphenyl sulphate) following dosing of 2-TFMA. These accounted for approximately 53.0 and 31.5% of the dose, respectively. This study identifies problems on sample component instability in the preparation and analysis procedures.

Diamonds at the golden point

CERN Multimedia

Katarina Anthony

2015-01-01

Alongside the CMS Pixel Luminosity Telescope (PLT) – installed last month (see here) – lie diamond detectors. No ordinary gems, these lab-grown diamonds will be playing a vital role in Run 2: differentiating signals from collision products with those from the beam background.   The BCM detector's green "c-shaped" printed circuit board is mounted on the PLT/BCM carbon-fibre carriage ready for installation. Earlier this year, the CMS BRIL project installed beam condition monitors (BCM) at the heart of the CMS detector. Designed to measure the online luminosity and beam background as close as possible to the LHC beam pipe, the BCMs use radiation-hard diamonds to differentiate between background and collision signals. The BCM also protects the CMS silicon trackers from damaging beam losses, by aborting the beam if the signal currents measured are above an acceptable threshold. These new BCMs are designed with Run 2 bunches in mind. &ldq...

Acoustic multivariate condition monitoring - AMCM

Energy Technology Data Exchange (ETDEWEB)

Rosenhave, P E [Vestfold College, Maritime Dept., Toensberg (Norway)

1998-12-31

In Norway, Vestfold College, Maritime Department presents new opportunities for non-invasive, on- or off-line acoustic monitoring of rotating machinery such as off-shore pumps and diesel engines. New developments within acoustic sensor technology coupled with chemometric data analysis of complex signals now allow condition monitoring of hitherto unavailable flexibility and diagnostic specificity. Chemometrics paired with existing knowledge yields a new and powerful tool for condition monitoring. By the use of multivariate techniques and acoustics it is possible to quantify wear and tear as well as predict the performance of working components in complex machinery. This presentation describes the AMCM method and one result of a feasibility study conducted onboard the LPG/C `Norgas Mariner` owned by Norwegian Gas Carriers as (NGC), Oslo. (orig.) 6 refs.

Acoustic multivariate condition monitoring - AMCM

Energy Technology Data Exchange (ETDEWEB)

Rosenhave, P.E. [Vestfold College, Maritime Dept., Toensberg (Norway)

1997-12-31

In Norway, Vestfold College, Maritime Department presents new opportunities for non-invasive, on- or off-line acoustic monitoring of rotating machinery such as off-shore pumps and diesel engines. New developments within acoustic sensor technology coupled with chemometric data analysis of complex signals now allow condition monitoring of hitherto unavailable flexibility and diagnostic specificity. Chemometrics paired with existing knowledge yields a new and powerful tool for condition monitoring. By the use of multivariate techniques and acoustics it is possible to quantify wear and tear as well as predict the performance of working components in complex machinery. This presentation describes the AMCM method and one result of a feasibility study conducted onboard the LPG/C `Norgas Mariner` owned by Norwegian Gas Carriers as (NGC), Oslo. (orig.) 6 refs.

Non-stationary condition monitoring through event alignment

DEFF Research Database (Denmark)

Pontoppidan, Niels Henrik; Larsen, Jan

2004-01-01

We present an event alignment framework which enables change detection in non-stationary signals. change detection. Classical condition monitoring frameworks have been restrained to laboratory settings with stationary operating conditions, which are not resembling real world operation....... In this paper we apply the technique for non-stationary condition monitoring of large diesel engines based on acoustical emission sensor signals. The performance of the event alignment is analyzed in an unsupervised probabilistic detection framework based on outlier detection with either Principal Component...... Analysis or Gaussian Processes modeling. We are especially interested in the true performance of the condition monitoring performance with mixed aligned and unaligned data, e.g. detection of fault condition of unaligned examples versus false alarms of aligned normal condition data. Further, we expect...

Integrated online condition monitoring system for nuclear power plants

International Nuclear Information System (INIS)

Hashemian, Hashem M.

2010-01-01

Online condition monitoring or online monitoring (OLM) uses data acquired while a nuclear power is operating to continuously assess the health of the plant's sensors, processes, and equipment; to measure the dynamic performance of the plant's process instrumentation; to verify in-situ the calibration of the process instrumentation; to detect blockages, voids, and leaks in the pressure sensing lines; to identify core flow anomalies; to extend the life of neutron detectors and other sensors; and to measure the vibration of reactor internals. Both the steady-state or DC output of plant sensors and their AC signal or noise output can be used to assess sensor health, depending on whether the application is monitoring a rapidly changing (e.g., core barrel motion) or a slowly changing (e.g., sensor calibration) process. The author has designed, developed, installed, and tested OLM systems (comprised of software/hardware-based data acquisition and data processing modules) that integrate low-frequency (1 mHz to 1 Hz) techniques such as RTD cross-calibration, pressure transmitter calibration monitoring, and equipment condition monitoring and high-frequency (1 Hz to 1 kHz) techniques such as the noise analysis technique. The author has demonstrated the noise analysis technique's effectiveness for measuring the dynamic response-time of pressure transmitters and their sensing lines; for performing predictive maintenance on reactor internals; for detecting core flow anomalies; and for extending neutron detector life. Integrated online condition monitoring systems can combine AC and DC data acquisition and signal processing techniques, can use data from existing process sensors during all modes of plant operation, including startup, normal operation, and shutdown; can be retrofitted into existing PWRs, BWRs, and other reactor types and will be integrated into next-generation plants. (orig.)

Integrated online condition monitoring system for nuclear power plants

Energy Technology Data Exchange (ETDEWEB)

Hashemian, Hashem M. [Analysis and Measurement Services Corporation, Knoxville, TN (United States). AMS Technology Center

2010-09-15

Online condition monitoring or online monitoring (OLM) uses data acquired while a nuclear power is operating to continuously assess the health of the plant's sensors, processes, and equipment; to measure the dynamic performance of the plant's process instrumentation; to verify in-situ the calibration of the process instrumentation; to detect blockages, voids, and leaks in the pressure sensing lines; to identify core flow anomalies; to extend the life of neutron detectors and other sensors; and to measure the vibration of reactor internals. Both the steady-state or DC output of plant sensors and their AC signal or noise output can be used to assess sensor health, depending on whether the application is monitoring a rapidly changing (e.g., core barrel motion) or a slowly changing (e.g., sensor calibration) process. The author has designed, developed, installed, and tested OLM systems (comprised of software/hardware-based data acquisition and data processing modules) that integrate low-frequency (1 mHz to 1 Hz) techniques such as RTD cross-calibration, pressure transmitter calibration monitoring, and equipment condition monitoring and high-frequency (1 Hz to 1 kHz) techniques such as the noise analysis technique. The author has demonstrated the noise analysis technique's effectiveness for measuring the dynamic response-time of pressure transmitters and their sensing lines; for performing predictive maintenance on reactor internals; for detecting core flow anomalies; and for extending neutron detector life. Integrated online condition monitoring systems can combine AC and DC data acquisition and signal processing techniques, can use data from existing process sensors during all modes of plant operation, including startup, normal operation, and shutdown; can be retrofitted into existing PWRs, BWRs, and other reactor types and will be integrated into next-generation plants. (orig.)

Proactive condition monitoring of low-speed machines

CERN Document Server

Stamboliska, Zhaklina; Moczko, Przemyslaw

2015-01-01

This book broadens readers’ understanding of proactive condition monitoring of low-speed machines in heavy industries. It focuses on why low-speed machines are different than others and how maintenance of these machines should be implemented with particular attention. The authors explain the best available monitoring techniques for various equipment and the principle of how to get proactive information from each technique. They further put forward possible strategies for application of FEM for detection of faults and technical assessment of machinery. Implementation phases are described and industrial case-studies of proactive condition monitoring are included. Proactive Condition Monitoring of Low-Speed Machines is an essential resource for engineers and technical managers across a range of industries as well as design engineers working in industrial product development. This book also: ·         Explains the practice of proactive condition monitoring and illustrates implementation phases ·   ...

Machinery condition monitoring principles and practices

CERN Document Server

Mohanty, Amiya Ranjan

2015-01-01

Find the Fault in the MachinesDrawing on the author's more than two decades of experience with machinery condition monitoring and consulting for industries in India and abroad, Machinery Condition Monitoring: Principles and Practices introduces the practicing engineer to the techniques used to effectively detect and diagnose faults in machines. Providing the working principle behind the instruments, the important elements of machines as well as the technique to understand their conditions, this text presents every available method of machine fault detection occurring in machines in general, an

Evaluation of 18F-FDG and 18F-FLT for monitoring therapeutic responses of colorectal cancer cells to radiotherapy

International Nuclear Information System (INIS)

Wang, Hui; Liu, Bo; Tian, Jiahe; Xu, Baixuan; Zhang, Jinming; Qu, Baolin; Chen, Yingmao

2013-01-01

In order to compare the efficacy of 18 F-fluorothymidine (FLT) and 18 F-fluorodeoxyglucose (FDG) for monitoring early responses to irradiation, two human colorectal cancer (CRC) cell lines SW480 and SW620, which were derived from the primary lesions and the metastatic lymph node, underwent X-ray irradiation of 0, 10, or 20 Gy and were examined at 0, 24 and 72 h After irradiation, reduced proliferation of both SW480 and SW620 cells was observed in a dose-dependent manner (P < 0.001), G0-G1 arrest was also noted in both cell types after 72 h in the 20 Gy group (P < 0.001). Although increased apoptosis was observed in both cell lines after irradiation (P < 0.001), a greater percentage of SW480 cells underwent apoptosis in response to irradiation than SW620 cells. Increased Hsp27 and decreased integrin β 3 , Ki67 and VEGFR2 expression was observed over time via immunocytochemistry and Western blot analysis (P < 0.001), however, no significant changes were noted in response to irradiation. Finally, reduced uptake of 18 F-FLT by SW480 or SW620 cells was observed at 24-h post-irradiation, however, reduced 18 F-FDG uptake was only observed after 72 h. Therefore, we conclude that 18 F-FLT is a more suitable positron emission tomography (PET) tracer for monitoring early responses to irradiation in primary and metastatic lymph node CRC cells

Technology review: prototyping platforms for monitoring ambient conditions.

Science.gov (United States)

Afolaranmi, Samuel Olaiya; Ramis Ferrer, Borja; Martinez Lastra, Jose Luis

2018-05-08

The monitoring of ambient conditions in indoor spaces is very essential owing to the amount of time spent indoors. Specifically, the monitoring of air quality is significant because contaminated air affects the health, comfort and productivity of occupants. This research work presents a technology review of prototyping platforms for monitoring ambient conditions in indoor spaces. It involves the research on sensors (for CO 2 , air quality and ambient conditions), IoT platforms, and novel and commercial prototyping platforms. The ultimate objective of this review is to enable the easy identification, selection and utilisation of the technologies best suited for monitoring ambient conditions in indoor spaces. Following the review, it is recommended to use metal oxide sensors, optical sensors and electrochemical sensors for IAQ monitoring (including NDIR sensors for CO 2 monitoring), Raspberry Pi for data processing, ZigBee and Wi-Fi for data communication, and ThingSpeak IoT platform for data storage, analysis and visualisation.

On the identification of fractionally cointegrated VAR models with the F(d) condition

DEFF Research Database (Denmark)

Santucci de Magistris, Paolo; Carlini, Federico

for any choice of the lag-length when the true cointegration rank is known. The properties of these multiple non-identified models are studied and a necessary and sufficient condition for the identification of the fractional parameters of the system is provided. The condition is named F(d......). This is a generalization of the well-known I(1) condition to the fractional case. Imposing a proper restriction on the fractional integration parameter, d, is sufficient to guarantee identification of all model parameters and the validity of the F(d) condition. The paper also illustrates the indeterminacy between...

Hubungan Metode Bermain, Cerita, dan Menyanyi (BCM dengan Prestasi Belajar Siswa SD menurut Persepsi Mahasiswa UIN Maulana Malik Ibrahim Malang

Directory of Open Access Journals (Sweden)

Purniadi Putra

2017-09-01

Full Text Available The use of play methods, stories and singing (BCM is expected to be easily understood and can increase the child's motivation for the child to get a good achievement. In line with this statement that one way to move the child's achievement is to create a fun learning condition because if the child is happy with the lesson they are going through then their children get a good achievement. This research method using quantitative research. Research location in UIN Maulana Malik Ibrahim Malang. The results describe the amount of variance that can be explained by the fakor formed in each variable. The value of communalities for the play method is 0.979 means that 98% of the factors formed are able to explain the variance of the facility attributes that support the singing method. Communalities for the story method variable is 0.719 meaning that 79% of the factors formed are able to explain the variance of the facility attributes that support the story method, and for the singing method variable is 0.60 means that 60% of the factor is able to explain the variance of the attribute that supports the singing method.

Technical guide for monitoring selected conditions related to wilderness character

Science.gov (United States)

Peter Landres; Steve Boutcher; Liese Dean; Troy Hall; Tamara Blett; Terry Carlson; Ann Mebane; Carol Hardy; Susan Rinehart; Linda Merigliano; David N. Cole; Andy Leach; Pam Wright; Deb Bumpus

2009-01-01

The purpose of monitoring wilderness character is to improve wilderness stewardship by providing managers a tool to assess how selected actions and conditions related to wilderness character are changing over time. Wilderness character monitoring provides information to help answer two key questions about wilderness character and wilderness stewardship: 1. How is...

On the identification of fractionally cointegrated VAR models with the F(d) condition

DEFF Research Database (Denmark)

Carlini, Federico; Santucci de Magistris, Paolo

for any choice of the lag length, also when the true cointegration rank is known. The properties of these multiple non-identified models are studied and a necessary and sufficient condition for the identification of the fractional parameters of the system is provided. The condition is named F(d......) and it is a generalization to the fractional case of the I(1) condition in the VECM model. The assessment of the F(d) condition in the empirical analysis is relevant for the determination of the fractional parameters as well as the number of lags. The paper also illustrates the indeterminacy between the cointegration rank...

Nonlinear GARCH model and 1 / f noise

Science.gov (United States)

Kononovicius, A.; Ruseckas, J.

2015-06-01

Auto-regressive conditionally heteroskedastic (ARCH) family models are still used, by practitioners in business and economic policy making, as a conditional volatility forecasting models. Furthermore ARCH models still are attracting an interest of the researchers. In this contribution we consider the well known GARCH(1,1) process and its nonlinear modifications, reminiscent of NGARCH model. We investigate the possibility to reproduce power law statistics, probability density function and power spectral density, using ARCH family models. For this purpose we derive stochastic differential equations from the GARCH processes in consideration. We find the obtained equations to be similar to a general class of stochastic differential equations known to reproduce power law statistics. We show that linear GARCH(1,1) process has power law distribution, but its power spectral density is Brownian noise-like. However, the nonlinear modifications exhibit both power law distribution and power spectral density of the 1 /fβ form, including 1 / f noise.

Support vector machine in machine condition monitoring and fault diagnosis

Science.gov (United States)

Widodo, Achmad; Yang, Bo-Suk

2007-08-01

Recently, the issue of machine condition monitoring and fault diagnosis as a part of maintenance system became global due to the potential advantages to be gained from reduced maintenance costs, improved productivity and increased machine availability. This paper presents a survey of machine condition monitoring and fault diagnosis using support vector machine (SVM). It attempts to summarize and review the recent research and developments of SVM in machine condition monitoring and diagnosis. Numerous methods have been developed based on intelligent systems such as artificial neural network, fuzzy expert system, condition-based reasoning, random forest, etc. However, the use of SVM for machine condition monitoring and fault diagnosis is still rare. SVM has excellent performance in generalization so it can produce high accuracy in classification for machine condition monitoring and diagnosis. Until 2006, the use of SVM in machine condition monitoring and fault diagnosis is tending to develop towards expertise orientation and problem-oriented domain. Finally, the ability to continually change and obtain a novel idea for machine condition monitoring and fault diagnosis using SVM will be future works.

Metabolic 19F MRI an dynamic 18F PET for chemotherapy monitoring in experimental tumors

International Nuclear Information System (INIS)

Brix, G.; Haberkorn, U.; Bellemann, M.E.

1999-01-01

The efficient clinical use of chemotherapeutic agents requires the assessment of the uptake and metabolism of the drugs in the tumor as well as in the various organs of the body by using noninvasive imaging techniques such as magnetic resonance imaging (MRI) and positron emission tomography (PET). In this overview, we present different metabolic 19 F MRI and dynamic 18 F PET techniques for noninvasive monitoring of fluorine-containing anticancer drugs and evaluate their potentials and limitations within the framework of experimental animal studies. (orig.) [de

Cisplatin-Induced Conditioned Taste Aversion: Attenuation by Dexamethasone but not Zacopride or GR38032F

Science.gov (United States)

1992-01-01

SR2-1 Cisplatin-induced conditioned taste aversion: ateuto by dexamethasone but not zacopride or GR38032F Nm I- Paul C Mele, John R. McDonough, David...to 5-H1’, receptor blockade. 5-HT., receptor antagonists; Zacopridc: GR38032F; Desamethasone: Cisplatin: Taste aversion (conditioned) I. Introductlon...intake) was used as the area known as the chemoreceptor trigger zone (Borri- index of the CTA. son, 1974). Moreover. the findings that rats, ferrets

Luminosity measurement at CMS

International Nuclear Information System (INIS)

Karacheban, Olena

2017-10-01

Luminosity is a key quantity of any collider, since it allows for the determination of the absolute cross sections from the observed rates in a detector. Since the Higgs boson discovery in 2012, the highest priority at the Large Hadron Collider (LHC) has been given to an accurate understanding of the electroweak scale and a search for new physics. Precise luminosity measurements in such conditions are of crucial importance, as they determine the precision of any physics cross section measurement. To increase the production of particles of interest, usually of low cross section, the LHC is running at the highest possible luminosity. After the first Long Shutdown (LS1) the original performance goal for the luminosity of 1 x 10 34 cm -2 s -1 was reached with 10 11 protons per bunch and a bunch spacing of 25 ns. In such conditions radiation hard detectors with extremely fast response time are required, especially for instrumentation near the beam. The Compact Muon Solenoid experiment is equipped with three online luminometers, which fulfill the listed requirements: the Fast Beam Conditions Monitor (BCM1F), the Pixel Luminosity Telescope (PLT) and the Forward Hadron calorimeter (HF). The BCM1F was upgraded during LS1 from 8 to 24 diamond sensors and is read out by a dedicated fast ASIC. The back-end comprises a deadtime-less histogramming unit, with 6.25 ns bin width and analog-to-digital converters with 2 ns sampling time in the VME standard. A microTCA system with better time resolution is in development. Particles originating from collisions and machine induced background arrive with 12 ns time difference. Because of its excellent time resolution BCM1F measures separately both luminosity and machine induced background particles. The performance of the detector in the first running period and radiation damage monitoring of the sensors and electronics chain form the first part of this thesis. Calibration of the luminometers at the LHC is done using van der Meer (Vd

Luminosity measurement at CMS

Energy Technology Data Exchange (ETDEWEB)

Karacheban, Olena

2017-10-15

Luminosity is a key quantity of any collider, since it allows for the determination of the absolute cross sections from the observed rates in a detector. Since the Higgs boson discovery in 2012, the highest priority at the Large Hadron Collider (LHC) has been given to an accurate understanding of the electroweak scale and a search for new physics. Precise luminosity measurements in such conditions are of crucial importance, as they determine the precision of any physics cross section measurement. To increase the production of particles of interest, usually of low cross section, the LHC is running at the highest possible luminosity. After the first Long Shutdown (LS1) the original performance goal for the luminosity of 1 x 10{sup 34} cm{sup -2} s{sup -1} was reached with 10{sup 11} protons per bunch and a bunch spacing of 25 ns. In such conditions radiation hard detectors with extremely fast response time are required, especially for instrumentation near the beam. The Compact Muon Solenoid experiment is equipped with three online luminometers, which fulfill the listed requirements: the Fast Beam Conditions Monitor (BCM1F), the Pixel Luminosity Telescope (PLT) and the Forward Hadron calorimeter (HF). The BCM1F was upgraded during LS1 from 8 to 24 diamond sensors and is read out by a dedicated fast ASIC. The back-end comprises a deadtime-less histogramming unit, with 6.25 ns bin width and analog-to-digital converters with 2 ns sampling time in the VME standard. A microTCA system with better time resolution is in development. Particles originating from collisions and machine induced background arrive with 12 ns time difference. Because of its excellent time resolution BCM1F measures separately both luminosity and machine induced background particles. The performance of the detector in the first running period and radiation damage monitoring of the sensors and electronics chain form the first part of this thesis. Calibration of the luminometers at the LHC is done using

Evaluation of {sup 18}F-FDG and {sup 18}F-FLT for monitoring therapeutic responses of colorectal cancer cells to radiotherapy

Energy Technology Data Exchange (ETDEWEB)

Wang, Hui [Nuclear Medicine Department, The General Hospital of the Chinese People' s Liberation Army and Military Medical Postgraduate College, Beijing 100853 (China); Liu, Bo [Department of Hepatobiliary Surgery, The General Hospital of the Chinese People' s Liberation Army and Military Medical Postgraduate College, Beijing 100853 (China); Tian, Jiahe, E-mail: tianjh@vip.sina.com [Nuclear Medicine Department, The General Hospital of the Chinese People' s Liberation Army and Military Medical Postgraduate College, Beijing 100853 (China); Xu, Baixuan; Zhang, Jinming [Nuclear Medicine Department, The General Hospital of the Chinese People' s Liberation Army and Military Medical Postgraduate College, Beijing 100853 (China); Qu, Baolin [Department of Radiation Oncology, The General Hospital of the Chinese People' s Liberation Army and Military Medical Postgraduate College, Beijing 100853 (China); Chen, Yingmao [Nuclear Medicine Department, The General Hospital of the Chinese People' s Liberation Army and Military Medical Postgraduate College, Beijing 100853 (China)

2013-09-15

In order to compare the efficacy of {sup 18}F-fluorothymidine (FLT) and {sup 18}F-fluorodeoxyglucose (FDG) for monitoring early responses to irradiation, two human colorectal cancer (CRC) cell lines SW480 and SW620, which were derived from the primary lesions and the metastatic lymph node, underwent X-ray irradiation of 0, 10, or 20 Gy and were examined at 0, 24 and 72 h After irradiation, reduced proliferation of both SW480 and SW620 cells was observed in a dose-dependent manner (P < 0.001), G0-G1 arrest was also noted in both cell types after 72 h in the 20 Gy group (P < 0.001). Although increased apoptosis was observed in both cell lines after irradiation (P < 0.001), a greater percentage of SW480 cells underwent apoptosis in response to irradiation than SW620 cells. Increased Hsp27 and decreased integrin β{sub 3}, Ki67 and VEGFR2 expression was observed over time via immunocytochemistry and Western blot analysis (P < 0.001), however, no significant changes were noted in response to irradiation. Finally, reduced uptake of {sup 18}F-FLT by SW480 or SW620 cells was observed at 24-h post-irradiation, however, reduced {sup 18}F-FDG uptake was only observed after 72 h. Therefore, we conclude that {sup 18}F-FLT is a more suitable positron emission tomography (PET) tracer for monitoring early responses to irradiation in primary and metastatic lymph node CRC cells.

Simultaneous monitoring of the two coupled motors of a single FoF1-ATP synthase by three-color FRET using duty cycle-optimized triple-ALEX

Science.gov (United States)

Zarrabi, N.; Ernst, S.; Düser, M. G.; Golovina-Leiker, A.; Becker, W.; Erdmann, R.; Dunn, S. D.; Börsch, M.

2009-02-01

FoF1-ATP synthase is the enzyme that provides the 'chemical energy currency' adenosine triphosphate, ATP, for living cells. The formation of ATP is accomplished by a stepwise internal rotation of subunits within the enzyme. Briefly, proton translocation through the membrane-bound Fo part of ATP synthase drives a 10-step rotary motion of the ring of c subunits with respect to the non-rotating subunits a and b. This rotation is transmitted to the γ and ɛ subunits of the F1 sector resulting in 120° steps. In order to unravel this symmetry mismatch we monitor subunit rotation by a single-molecule fluorescence resonance energy transfer (FRET) approach using three fluorophores specifically attached to the enzyme: one attached to the F1 motor, another one to the Fo motor, and the third one to a non-rotating subunit. To reduce photophysical artifacts due to spectral fluctuations of the single fluorophores, a duty cycle-optimized alternating three-laser scheme (DCO-ALEX) has been developed. Simultaneous observation of the stepsizes for both motors allows the detection of reversible elastic deformations between the rotor parts of Fo and F1.

Modern techniques for condition monitoring of railway vehicle dynamics

International Nuclear Information System (INIS)

Ngigi, R W; Pislaru, C; Ball, A; Gu, F

2012-01-01

A modern railway system relies on sophisticated monitoring systems for maintenance and renewal activities. Some of the existing conditions monitoring techniques perform fault detection using advanced filtering, system identification and signal analysis methods. These theoretical approaches do not require complex mathematical models of the system and can overcome potential difficulties associated with nonlinearities and parameter variations in the system. Practical applications of condition monitoring tools use sensors which are mounted either on the track or rolling stock. For instance, monitoring wheelset dynamics could be done through the use of track-mounted sensors, while vehicle-based sensors are preferred for monitoring the train infrastructure. This paper attempts to collate and critically appraise the modern techniques used for condition monitoring of railway vehicle dynamics by analysing the advantages and shortcomings of these methods.

Quaternion Based Thermal Condition Monitoring System

Science.gov (United States)

Wong, Wai Kit; Loo, Chu Kiong; Lim, Way Soong; Tan, Poi Ngee

In this paper, we will propose a new and effective machine condition monitoring system using log-polar mapper, quaternion based thermal image correlator and max-product fuzzy neural network classifier. Two classification characteristics namely: peak to sidelobe ratio (PSR) and real to complex ratio of the discrete quaternion correlation output (p-value) are applied in the proposed machine condition monitoring system. Large PSR and p-value observe in a good match among correlation of the input thermal image with a particular reference image, while small PSR and p-value observe in a bad/not match among correlation of the input thermal image with a particular reference image. In simulation, we also discover that log-polar mapping actually help solving rotation and scaling invariant problems in quaternion based thermal image correlation. Beside that, log-polar mapping can have a two fold of data compression capability. Log-polar mapping can help smoother up the output correlation plane too, hence makes a better measurement way for PSR and p-values. Simulation results also show that the proposed system is an efficient machine condition monitoring system with accuracy more than 98%.

Isotope dilution liquid chromatography-tandem mass spectrometry for simultaneous identification and quantification of beta-casomorphin 5 and beta-casomorphin 7 in yoghurt.

Science.gov (United States)

Nguyen, D D; Solah, V A; Johnson, S K; Charrois, J W A; Busetti, F

2014-03-01

A highly selective and sensitive liquid chromatography-tandem mass spectrometry method was developed and validated for the simultaneous identification and quantification of beta-casomorphin 5 (BCM5) and beta-casomorphin 7 (BCM7) in yoghurt. The method used deuterium labelled BCM5-d10 and BCM7-d10 as surrogate standards for confident identification and accurate and quantification of these analytes in yoghurt. Linear responses for BCM5 and BCM7 (R(2)=0.9985 and 0.9986, respectively) was observed in the range 0.01-10ng/μL. The method limits of detection (MLDs) in yoghurt extracts were found to be 0.5 and 0.25ng/g for BCM5 and BCM7, respectively. Analyses of spiked samples were used to provide confirmation of accuracy and precision of the analytical method. Recoveries relative to the surrogate standards of these spikes were in the range of 95-106% for BCM5 and 103-109% for BCM7. Precision from analysis of spiked samples was expressed as relative standard deviation (%RSD) and values were in the range 1-16% for BCM5 and 1-6% for BCM7. Inter-day reproducibility was between 2.0-6.4% for BCM5 and between 3.2-6.1% for BCM7. The validated isotope dilution LC-MS/MS method was used to measure BCM5 and BCM7 in ten commercial and laboratory prepared samples of yoghurt and milk. Neither BCM5 nor BCM7 was detected in commercial yoghurts. However, they were observed in milk and laboratory prepared yoghurts and interestingly their levels decreased during processing. BCM5 decreased from 1.3ng/g in milk to 1.1ng/g in yoghurt made from that milk at 0day storage and 1 and 7days storage. BCM7 decreased from 1.9ng/g in milk to BCM5 and BCM7 concentration in yoghurt. Copyright © 2013 Elsevier Ltd. All rights reserved.

Physical working conditions as covered in European monitoring questionnaires

Directory of Open Access Journals (Sweden)

Tore Tynes

2017-06-01

Full Text Available Abstract Background The prevalence of workers with demanding physical working conditions in the European work force remains high, and occupational physical exposures are considered important risk factors for musculoskeletal disorders (MSD, a major burden for both workers and society. Exposures to physical workloads are therefore part of the European nationwide surveys to monitor working conditions and health. An interesting question is to what extent the same domains, dimensions and items referring to the physical workloads are covered in the surveys. The purpose of this paper is to determine 1 which domains and dimensions of the physical workloads are monitored in surveys at the national level and the EU level and 2 the degree of European consensus among these surveys regarding coverage of individual domains and dimensions. Method Items on physical workloads used in one European wide/Spanish and five other European nationwide work environment surveys were classified into the domains and dimensions they cover, using a taxonomy agreed upon among all participating partners. Results The taxonomy reveals that there is a modest overlap between the domains covered in the surveys, but when considering dimensions, the results indicate a lower agreement. The phrasing of items and answering categories differs between the surveys. Among the domains, the three domains covered by all surveys are “lifting, holding & carrying of loads/pushing & pulling of loads”, “awkward body postures” and “vibrations”. The three domains covered less well, that is only by three surveys or less, are “physical work effort”, “working sitting”, and “mixed exposure”. Conclusions This is the fırst thorough overview to evaluate the coverage of domains and dimensions of self-reported physical workloads in a selection of European nationwide surveys. We hope the overview will provide input to the revisions and updates of the individual countries’ surveys in

Characterisation and application of radiation hard sensors for LHC and ILC

International Nuclear Information System (INIS)

Novgorodova, Olga

2013-11-01

The Large Hadron Collider (LHC) currently in operation intends to explore particle physics on the TeV scale. The International Linear Collider (ILC) and the Compact Linear Collider (CLIC) are being designed to measure the properties of particles discovered at the LHC with higher precision. Very forward detector systems at these machines are needed for the precise measurement of the luminosity and to approach full polar angle overage. In the current detector concepts for linear collider two electromagnetic calorimeters, Beam Calorimeter (BeamCal) and Luminosity Calorimeter (LumiCal), are foreseen. Both calorimeters are designed as sandwich calorimeters with tungsten absorber layers instrumented with finely segmented sensors. Due to a large amount of beamstrahlung remnants hitting BeamCal at the innermost radii, the sensors must withstand up to 1 MGy radiation dose per year. In this thesis two types of sensor materials were investigated: single crystal chemical vapour deposition diamonds (scCVDD) and gallium arsenide doped by chromium (GaAs:Cr). The very forward calorimeters ensure coverage for high energy electrons, positrons and photons down to very low polar angles. Within this thesis, simulation studies are presented for different beam parameters of the ILC. A new sensor segmentation was proposed to achieve better reconstruction efficiency of single high-energy electrons, positrons and photons on top of the beamstrahlung background. Only for a few years ago polycrystalline diamond sensors have been used for beam diagnostics in high-energy physics experiments. The Compact Muon Solenoid experiment, CMS, at the LHC is instrumented with several detectors for the Beam Conditions and Radiation Monitoring. The Fast Beam Conditions Monitor (BCM1F) is part of these systems. Here for the first time single crystal diamond sensors have been used. Eight detectors, comprising each a single crystal sensor and front-end electronics, are positioned around the beam pipe on both

Characterisation and application of radiation hard sensors for LHC and ILC

Energy Technology Data Exchange (ETDEWEB)

Novgorodova, Olga

2013-11-15

The Large Hadron Collider (LHC) currently in operation intends to explore particle physics on the TeV scale. The International Linear Collider (ILC) and the Compact Linear Collider (CLIC) are being designed to measure the properties of particles discovered at the LHC with higher precision. Very forward detector systems at these machines are needed for the precise measurement of the luminosity and to approach full polar angle overage. In the current detector concepts for linear collider two electromagnetic calorimeters, Beam Calorimeter (BeamCal) and Luminosity Calorimeter (LumiCal), are foreseen. Both calorimeters are designed as sandwich calorimeters with tungsten absorber layers instrumented with finely segmented sensors. Due to a large amount of beamstrahlung remnants hitting BeamCal at the innermost radii, the sensors must withstand up to 1 MGy radiation dose per year. In this thesis two types of sensor materials were investigated: single crystal chemical vapour deposition diamonds (scCVDD) and gallium arsenide doped by chromium (GaAs:Cr). The very forward calorimeters ensure coverage for high energy electrons, positrons and photons down to very low polar angles. Within this thesis, simulation studies are presented for different beam parameters of the ILC. A new sensor segmentation was proposed to achieve better reconstruction efficiency of single high-energy electrons, positrons and photons on top of the beamstrahlung background. Only for a few years ago polycrystalline diamond sensors have been used for beam diagnostics in high-energy physics experiments. The Compact Muon Solenoid experiment, CMS, at the LHC is instrumented with several detectors for the Beam Conditions and Radiation Monitoring. The Fast Beam Conditions Monitor (BCM1F) is part of these systems. Here for the first time single crystal diamond sensors have been used. Eight detectors, comprising each a single crystal sensor and front-end electronics, are positioned around the beam pipe on both

Condition monitoring a key component in the preventive maintenance

International Nuclear Information System (INIS)

Isar, C.

2006-01-01

The preventive maintenance programs are necessary to ensure that nuclear safety significant equipment will function when it is supposed to. Diesel generator, pumps, motor operated valves and air operated control valves are typically operated every three months. When you drive a car, you depend on lot of sounds, the feel of the steering wheel and gauges to determine if the car is running correctly. Similarly with operating equipment for a power plant - sounds or vibration of the equipment or the gauges and test equipment indicate a problem or degradation, actions are taken to correct the deficiency. Due to safety and economical reason diagnostic and monitoring systems are of growing interest in all complex industrial production. Diagnostic systems are requested to detect, diagnose and localize faulty operating conditions at an early stage in order to prevent severe failures and to enable predictive and condition oriented maintenance. In this context it is a need for using various on-line and off-line condition monitoring and diagnostics, non-destructive inspection techniques and surveillance. The condition monitoring technique used in nuclear power plant Cernavoda are presented in this paper. The selection of components and parameters to be monitored, monitoring and diagnostics techniques used are incorporated into a preventive maintenance program. Modern measurement technique in combination with advanced computerized data processing and acquisition show new ways in the field of machine surveillance. The diagnostic capabilities of predictive maintenance technologies have increased recently year with advances made in sensor technologies. The paper will focus on the following condition monitoring technique: - oil analysis - acoustic leakage monitoring - thermography - valve diagnostics: motor operated valve, air operated valve and check valve - motor current signature - vibration monitoring and rotating machine monitoring and diagnostics For each condition monitoring

A DSP-Based Beam Current Monitoring System for Machine Protection Using Adaptive Filtering

International Nuclear Information System (INIS)

J. Musson; H. Dong; R. Flood; C. Hovater; J. Hereford

2001-01-01

The CEBAF accelerator at Jefferson Lab is currently using an analog beam current monitoring (BCM) system for its machine protection system (MPS), which has a loss accuracy of 2 micro-amps. Recent burn-through simulations predict catastrophic beam line component failures below 1 micro-amp of loss, resulting in a blind spot for the MPS. Revised MPS requirements target an ultimate beam loss accuracy of 250 nA. A new beam current monitoring system has been developed which utilizes modern digital receiver technology and digital signal processing concepts. The receiver employs a direct-digital down converter integrated circuit, mated with a Jefferson Lab digital signal processor VME card. Adaptive filtering is used to take advantage of current-dependent burn-through rates. Benefits of such a system include elimination of DC offsets, generic algorithm development, extensive filter options, and interfaces to UNIX-based control systems

Use of Low-Cost Acquisition Systems with an Embedded Linux Device for Volcanic Monitoring.

Science.gov (United States)

Moure, David; Torres, Pedro; Casas, Benito; Toma, Daniel; Blanco, María José; Del Río, Joaquín; Manuel, Antoni

2015-08-19

This paper describes the development of a low-cost multiparameter acquisition system for volcanic monitoring that is applicable to gravimetry and geodesy, as well as to the visual monitoring of volcanic activity. The acquisition system was developed using a System on a Chip (SoC) Broadcom BCM2835 Linux operating system (based on DebianTM) that allows for the construction of a complete monitoring system offering multiple possibilities for storage, data-processing, configuration, and the real-time monitoring of volcanic activity. This multiparametric acquisition system was developed with a software environment, as well as with different hardware modules designed for each parameter to be monitored. The device presented here has been used and validated under different scenarios for monitoring ocean tides, ground deformation, and gravity, as well as for monitoring with images the island of Tenerife and ground deformation on the island of El Hierro.

Conditional E2F1 activation in transgenic mice causes testicular atrophy and dysplasia mimicking human CIS

DEFF Research Database (Denmark)

Agger, Karl; Santoni-Rugiu, Eric; Holmberg, Christian

2005-01-01

E2F1 is a crucial downstream effector of the retinoblastoma protein (pRB) pathway. To address the consequences of short-term increase in E2F1 activity in adult tissues, we generated transgenic mice expressing the human E2F1 protein fused to the oestrogen receptor (ER) ligand-binding domain...

Results of the F/H Effluent Treatment Facility biological monitoring program, July 1987--July 1991

International Nuclear Information System (INIS)

Specht, W.L.

1992-07-01

As required by the South Carolina Department of Health and Environmental Control (SCDHEC) under NPDES Permit SCO000175, biological monitoring was conducted in Upper Three Runs Creek to determine if discharges from the F/H Effluent Treatment Facility have adversely impacted the biotic community of the receiving stream. Data included in this summary report encompass July 1987 through July 1991. As originally designed, the F/H ETF was not expected to remove all of the mercury from the wastewater; therefore, SCDHEC specified that studies be conducted to determine if mercury was bioaccumulating in aquatic biota. Subsequent to approval of the biological monitoring program, an ion exchange column was added to the F/H ETF specifically to remove mercury, which eliminated mercury from the F/H ETF effluent. The results of the biological monitoring program indicate that at the present rate of discharge, the F/H ETF effluent has not adversely affected the receiving stream with respect to any of the parameters that were measured. The effluent is not toxic at the in-stream waste concentration and there is no evidence of mercury bioaccumulation

Muscular condition monitoring system using fiber bragg grating sensors

International Nuclear Information System (INIS)

Kim, Heon Young; Lee, Jin Hyuk; Kim, Dae Hyun

2014-01-01

Fiber optic sensors (FOS) have advantages such as electromagnetic interference (EMI) immunity, corrosion resistance and multiplexing capability. For these reasons, they are widely used in various condition monitoring systems (CMS). This study investigated a muscular condition monitoring system using fiber optic sensors (FOS). Generally, sensors for monitoring the condition of the human body are based on electro-magnetic devices. However, such an electrical system has several weaknesses, including the potential for electro-magnetic interference and distortion. Fiber Bragg grating (FBG) sensors overcome these weaknesses, along with simplifying the devices and increasing user convenience. To measure the level of muscle contraction and relaxation, which indicates the muscle condition, a belt-shaped FBG sensor module that makes it possible to monitor the movement of muscles in the radial and circumferential directions was fabricated in this study. In addition, a uniaxial tensile test was carried out in order to evaluate the applicability of this FBG sensor module. Based on the experimental results, a relationship was observed between the tensile stress and Bragg wavelength of the FBG sensors, which revealed the possibility of fabricating a muscular condition monitoring system based on FBG sensors.

Muscular condition monitoring system using fiber bragg grating sensors

Energy Technology Data Exchange (ETDEWEB)

Kim, Heon Young; Lee, Jin Hyuk; Kim, Dae Hyun [Seoul National University of Technology, Seoul (Korea, Republic of)

2014-10-15

Fiber optic sensors (FOS) have advantages such as electromagnetic interference (EMI) immunity, corrosion resistance and multiplexing capability. For these reasons, they are widely used in various condition monitoring systems (CMS). This study investigated a muscular condition monitoring system using fiber optic sensors (FOS). Generally, sensors for monitoring the condition of the human body are based on electro-magnetic devices. However, such an electrical system has several weaknesses, including the potential for electro-magnetic interference and distortion. Fiber Bragg grating (FBG) sensors overcome these weaknesses, along with simplifying the devices and increasing user convenience. To measure the level of muscle contraction and relaxation, which indicates the muscle condition, a belt-shaped FBG sensor module that makes it possible to monitor the movement of muscles in the radial and circumferential directions was fabricated in this study. In addition, a uniaxial tensile test was carried out in order to evaluate the applicability of this FBG sensor module. Based on the experimental results, a relationship was observed between the tensile stress and Bragg wavelength of the FBG sensors, which revealed the possibility of fabricating a muscular condition monitoring system based on FBG sensors.

A Voltage-Based STDP Rule Combined with Fast BCM-Like Metaplasticity Accounts for LTP and Concurrent "Heterosynaptic" LTD in the Dentate Gyrus In Vivo.

Directory of Open Access Journals (Sweden)

Peter Jedlicka

2015-11-01

Full Text Available Long-term potentiation (LTP and long-term depression (LTD are widely accepted to be synaptic mechanisms involved in learning and memory. It remains uncertain, however, which particular activity rules are utilized by hippocampal neurons to induce LTP and LTD in behaving animals. Recent experiments in the dentate gyrus of freely moving rats revealed an unexpected pattern of LTP and LTD from high-frequency perforant path stimulation. While 400 Hz theta-burst stimulation (400-TBS and 400 Hz delta-burst stimulation (400-DBS elicited substantial LTP of the tetanized medial path input and, concurrently, LTD of the non-tetanized lateral path input, 100 Hz theta-burst stimulation (100-TBS, a normally efficient LTP protocol for in vitro preparations produced only weak LTP and concurrent LTD. Here we show in a biophysically realistic compartmental granule cell model that this pattern of results can be accounted for by a voltage-based spike-timing-dependent plasticity (STDP rule combined with a relatively fast Bienenstock-Cooper-Munro (BCM-like homeostatic metaplasticity rule, all on a background of ongoing spontaneous activity in the input fibers. Our results suggest that, at least for dentate granule cells, the interplay of STDP-BCM plasticity rules and ongoing pre- and postsynaptic background activity determines not only the degree of input-specific LTP elicited by various plasticity-inducing protocols, but also the degree of associated LTD in neighboring non-tetanized inputs, as generated by the ongoing constitutive activity at these synapses.

Vibration-based condition monitoring industrial, aerospace and automotive applications

CERN Document Server

Randall, Robert Bond

2010-01-01

""Without doubt the best modern and up-to-date text on the topic, wirtten by one of the world leading experts in the field. Should be on the desk of any practitioner or researcher involved in the field of Machine Condition Monitoring"" Simon Braun, Israel Institute of Technology Explaining complex ideas in an easy to understand way, Vibration-based Condition Monitoring provides a comprehensive survey of the application of vibration analysis to the condition monitoring of machines. Reflecting the natural progression of these systems by presenting the fundamental material

Operational performance of generator condition monitors

International Nuclear Information System (INIS)

Braun, J.M.; Brown, G.

1990-01-01

This paper reports on the generator condition monitor (GCM) developed in an attempt to detect overheating inside large turbine generators. As part of a broader study on rotating machinery diagnostics, generator condition monitors were evaluated under field conditions in a 550 MW turbogenerator. Small 100 W resistors coated with insulating paints and varnishes were mounted inside the generator to simulate insulation overheating. The GCM responded very rapidly to an overheating event, typically within two minutes, even for hot spots as small s 10 cm 2 . Similarly the aerosols produced on overheating were found extremely short lived, decaying within two to three minutes after overheating was discontinued. Use of heated ion chambers was found to desensitize the GCM regardless of the nature of the overheated insulation and in some cases would altogether prevent the GCM from reaching the 50% pre-set alarm level commonly used on GCMs

When is f(x1,x2,... ,xn)

Indian Academy of Sciences (India)

R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

When is f(x1,x2,... ,xn) = u1(x1) + u2(x2) +···+ un(xn)? ... (i) there exist non-zero integers p1,p2,... ,pk such that ..... probability measure for the countable collection of functions 1Ai , i = 1, 2, 3,. .... For question (B) a sufficient condition is that.

Condition Monitoring of the SSE Generation Fleet

Science.gov (United States)

Twiddle, J.; Muthuraman, S.; Connolly, N.

2012-05-01

SSE (previously known as Scottish and Southern Energy) operates a diverse portfolio of generation plant, including coal, gas and renewable plant with a total generation capacity of 11,375MW (Sept 2011). In recent years a group of specialists dedicated to providing condition monitoring services has been established at the Equipment Performance Centre (EPC) based at Knottingley, West Yorkshire. We aim to illustrate the role of the EPC and the methods used for monitoring the generation fleet with the objective of maintaining asset integrity, reducing risk of plant failure and unplanned outages and describe the challenges which have been overcome in establishing the EPC. This paper describes methods including vibration and process data analysis, model-based techniques and on-site testing used for monitoring of generation plant, including gas turbines, steam turbines, generators and steam raising plant. These condition monitoring processes utilise available data, adding value to the business, by bringing services in-house and capturing knowledge of plant operation for the benefit of the whole fleet.

F-Area Seepage Basins groundwater monitoring report -- third and fourth quarters 1993

International Nuclear Information System (INIS)

Butler, C.T.

1994-03-01

During the second half of 1993, the groundwater at the F-Area Seepage Basins (FASB) was monitored in compliance with Module 3, Section C, of South Carolina Hazardous Waste Permit SC1-890-008-989, effective November 2, 1992. The monitoring well network is composed of 87 FSB wells screened in the three hydrostratigraphic units that make up the uppermost aquifer beneath the FASB. A detailed description of the uppermost aquifer is included in the Resource Conservation and Recovery Act Part B post-closure care permit application for the F-Area Hazardous Waste Management Facility submitted to the South Carolina Department of Health and Environmental Control (SCDHEC) in December 1990. Beginning in the first quarter of 1993, the standard for comparison became the SCDHEC Groundwater Protection Standard (GWPS) specified in the approved F-Area Seepage Basins Part B permit. Currently and historically, gross alpha, nitrate, nonvolatile beta, and tritium are among the primary constituents to exceed standards. Numerous other radionuclides and hazardous constituents also exceeded the GWPS in the groundwater at the FASB during the second half of 1993, notably aluminum, iodine-129, and zinc. The elevated constituents are found primarily in Aquifer Zone 2B 2 and Aquifer Zone 2B 1 wells. However, several Aquifer Unit 2A wells also contain elevated levels of constituents. Isoconcentration/isoactivity maps included in this report indicate both the concentration/activity and extent of the primary contaminants in each of the three hydrostratigraphic units. Water-level maps indicate that the groundwater flow rates and directions at the FASB have remained relatively constant since the basins ceased to be active in 1988

Evaluation of the RSG-GAS Alpha-Beta Aerosol Contaminant Monitor Performance Under Reactor Operation Condition

International Nuclear Information System (INIS)

Hartoyo, Unggul; Setiawanto, Anto; Sumarno, Yulius

2000-01-01

Analysis to evaluate the RSG-GAS alpha-beta aerosol contaminant monitor performance was done. The high potential radiation working area such as in RSG-GAS is important to monitored for personal safety. Further it is necessary to assure that the system monitor is reliable enough under normal conditions as well as emergency condition. The method uses in this analysis are monitoring and comparing with the standard source. The standard course indicator and panel in main control room indicate that the result is 1 x 110 exp 9 Ci/m exp 3. Based on data monitor observation, the RSG-GAS alpha-beta aerosol contaminant monitor system under reactor operation condition has a good enough performance

Wind Turbine Gearbox Oil Filtration and Condition Monitoring

Energy Technology Data Exchange (ETDEWEB)

Sheng, Shuangwen

2015-10-25

This is an invited presentation for a pre-conference workshop, titled advances and opportunities in lubrication: wind turbine, at the 2015 Society of Tribologists and Lubrication Engineers (STLE) Tribology Frontiers Conference held in Denver, CO. It gives a brief overview of wind turbine gearbox oil filtration and condition monitoring by highlighting typical industry practices and challenges. The presentation starts with an introduction by covering recent growth of global wind industry, reliability challenges, benefits of oil filtration and condition monitoring, and financial incentives to conduct wind operation and maintenance research, which includes gearbox oil filtration and condition monitoring work presented herein. Then, the presentation moves on to oil filtration by stressing the benefits of filtration, discussing typical main- and offline-loop practices, highlighting important factors considered when specifying a filtration system, and illustrating real-world application challenges through a cold-start example. In the next section on oil condition monitoring, a discussion on oil sample analysis, oil debris monitoring, oil cleanliness measurements and filter analysis is given based on testing results mostly obtained by and at NREL, and by pointing out a few challenges with oil sample analysis. The presentation concludes with a brief touch on future research and development (R and D) opportunities. It is hoping that the information presented can inform the STLE community to start or redirect their R and D work to help the wind industry advance.

Cosmological viability conditions for f(T) dark energy models

Energy Technology Data Exchange (ETDEWEB)

Setare, M.R.; Mohammadipour, N., E-mail: rezakord@ipm.ir, E-mail: N.Mohammadipour@uok.ac.ir [Department of Science, University of Kurdistan, Sanandaj (Iran, Islamic Republic of)

2012-11-01

Recently f(T) modified teleparallel gravity where T is the torsion scalar has been proposed as the natural gravitational alternative for dark energy. We perform a detailed dynamical analysis of these models and find conditions for the cosmological viability of f(T) dark energy models as geometrical constraints on the derivatives of these models. We show that in the phase space exists two cosmologically viable trajectory which (i) The universe would start from an unstable radiation point, then pass a saddle standard matter point which is followed by accelerated expansion de sitter point. (ii) The universe starts from a saddle radiation epoch, then falls onto the stable matter era and the system can not evolve to the dark energy dominated epoch. Finally, for a number of f(T) dark energy models were proposed in the more literature, the viability conditions are investigated.

Atomic structure of CaF2/MnF2-Si(1 1 1) superlattices from X-ray diffraction

International Nuclear Information System (INIS)

Alcock, Simon G.; Nicklin, C.L.; Howes, P.B.; Norris, C.A.; Kyutt, R.N.; Sokolov, N.S.; Yakovlev, N.L.

2007-01-01

X-ray reflectivity and non-specular crystal truncation rod scans have been used to determine the three-dimensional atomic structure of the buried CaF 2 -Si(1 1 1) interface and ultrathin films of MnF 2 and CaF 2 within a superlattice. We show that ultrathin films of MnF 2 , below a critical thickness of approximately four monolayers, are crystalline, pseudomorphic, and adopt the fluorite structure of CaF 2 . High temperature deposition of the CaF 2 buffer layer produces a fully reacted, CaF 2 -Si(1 1 1) type-B interface. The mature, 'long' interface is shown to consist of a partially occupied layer of CaF bonded to the Si substrate, followed by a distorted CaF layer. Our atomistic, semi-kinematical scattering method extends the slab reflectivity method by providing in-plane structural information

Decision Support System for Condition Monitoring Technologies

NARCIS (Netherlands)

Mouatamir, Abderrahim

2018-01-01

The technological feasibility of a condition-based maintenance (CBM) policy is intrinsically related to the suitable selection of condition monitoring (CM) technologies such as vibration- and oil analysis or other non-destructive testing (NDT) techniques such as radiographic- and magnetic particle

A study on the condition monitoring for safety-related electric cables

Energy Technology Data Exchange (ETDEWEB)

Kim, Chul Hwan; Ahn, S. P.; Yeo, S. M.; Kang, Y. S.; Ahn, S. M.; Kim, I. S.; Kim, D. S.; Kang, J. S. [Sungkyunkwan Univ., Suwon (Korea, Republic of)

2002-03-15

In this report, we have studied compositions and characteristics of various types of insulation material for cables in Nuclear Power Plant. We arrange relationship with condition monitoring methods. Also, we propose new condition monitoring method using third harmonic frequency. We test the proposed method with CV cables. We also describe about feature of condition monitoring such as application, theory, characteristic, thereby other engineer can confirm to advantage and disadvantage for each method, and possibly choice adequate condition monitoring method for various types of cables.

Integrated reliability condition monitoring and maintenance of equipment

CERN Document Server

Osarenren, John

2015-01-01

Consider a Viable and Cost-Effective Platform for the Industries of the Future (IOF) Benefit from improved safety, performance, and product deliveries to your customers. Achieve a higher rate of equipment availability, performance, product quality, and reliability. Integrated Reliability: Condition Monitoring and Maintenance of Equipment incorporates reliable engineering and mathematical modeling to help you move toward sustainable development in reliability condition monitoring and maintenance. This text introduces a cost-effective integrated reliability growth monitor, integrated reliability degradation monitor, technological inheritance coefficient sensors, and a maintenance tool that supplies real-time information for predicting and preventing potential failures of manufacturing processes and equipment. The author highlights five key elements that are essential to any improvement program: improving overall equipment and part effectiveness, quality, and reliability; improving process performance with maint...

Interference Tolerant Functional Near Infrared Spectrometer (fNIRS) for Cognitive State Monitoring

Data.gov (United States)

National Aeronautics and Space Administration — Measuring hemoglobin concentration changes in the brain with Functional Near Infrared Spectroscopy (fNIRS) is a promising technique for monitoring cognitive state...

Workshop on power plant cable condition monitoring: Proceedings

International Nuclear Information System (INIS)

Del Valle, L.

1988-07-01

A three-day workshop on cable condition monitoring was held in San Francisco on Fegruary 16--18, 1988. The workshop was cosponsored by the Nuclear Power, Electrical Systems, and Coal Combustion Systems Divisions of the Electric Power Research Institute. The primary objective of the workshop was to identify the state-of-the-art for cable condition monitoring. Twenty-five technical papers as well as EPRI research programs were presented at the technical sessions. Four working group sessions and one general session were held on each of two days. Each group session provided a forum for participants to exchange ideas and to discuss in more depth research for cable condition monitoring, existing and innovative testing technology, and utility and NRC needs for testing. Recommendations from the working groups were summarized and presented at the end of the workshop

F-Area Acid/Caustic Basin groundwater monitoring report. Second quarter 1994

International Nuclear Information System (INIS)

1994-09-01

During second quarter 1994, samples from the FAC monitoring wells at the F-Area Acid/Caustic Basin were collected and analyzed for herbicides/pesticides, indicator parameters, metals, nitrate, radionuclide indicators, volatile organic compounds, and other constituents. Piezometer FAC 5P and monitoring well FAC 6 were dry and could not be sampled. Analytical results that exceeded final Primary Drinking Water Standards (PDWS), other Savannah River Site (SRS) Flag 2 criteria, or the SRS turbidity standard of 50 NTU during the quarter were as follows: gross alpha exceeded the final PDWS and aluminum, iron, manganese, and total organic halogens exceeded the SRS Flag 2 criteria in one or more of the FAC wells. Turbidity exceeded the SRS standard in well FAC 3. Groundwater flow direction and rate in the water table beneath the F-Area Acid/Caustic Basin were similar to past quarters

[18F]FE@SNAP—A new PET tracer for the melanin concentrating hormone receptor 1 (MCHR1): Microfluidic and vessel-based approaches

Science.gov (United States)

Philippe, Cécile; Ungersboeck, Johanna; Schirmer, Eva; Zdravkovic, Milica; Nics, Lukas; Zeilinger, Markus; Shanab, Karem; Lanzenberger, Rupert; Karanikas, Georgios; Spreitzer, Helmut; Viernstein, Helmut; Mitterhauser, Markus; Wadsak, Wolfgang

2012-01-01

Changes in the expression of the melanin concentrating hormone receptor 1 (MCHR1) are involved in a variety of pathologies, especially obesity and anxiety disorders. To monitor these pathologies in-vivo positron emission tomography (PET) is a suitable method. After the successful radiosynthesis of [11C]SNAP-7941—the first PET-Tracer for the MCHR1, we aimed to synthesize its [18F]fluoroethylated analogue: [18F]FE@SNAP. Therefore, microfluidic and vessel-based approaches were tested. [18F]fluoroethylation was conducted via various [18F]fluoroalkylated synthons and direct [18F]fluorination. Only the direct [18F]fluorination of a tosylated precursor using a flow-through microreactor was successful, affording [18F]FE@SNAP in 44.3 ± 2.6%. PMID:22921745

F-GUTs with Mordell-Weil U(1)'s

CERN Document Server

Antoniadis, I

2014-01-01

In this note we study the constraints on F-theory GUTs with extra $U(1)$'s in the context of elliptic fibrations with rational sections. We consider the simplest case of one abelian factor (Mordell-Weil rank one) and investigate the conditions that are induced on the coefficients of its Tate form. Converting the equation representing the generic hypersurface $P_{112}$ to this Tate's form we find that the presence of a U(1), already in this local description, is consistent with the exceptional ${\\cal E}_6$ and ${\\cal E}_7$ non-abelian singularities. We briefly comment on a viable ${\\cal E}_6\\times U(1)$ effective F-theory model.

Emittance scans for CMS luminosity calibration in 2017

CERN Document Server

CMS Collaboration

2018-01-01

Emittance scans are short van der Meer type scans performed at the beginning and at the end of LHC fills. The beams are scanned against each other in X and Y planes in 7 displacement steps. These scans are used for LHC diagnostics and since 2017 for a cross check of the CMS luminosity calibration. An XY pair of scans takes around 3 minutes. The BRIL project provides to LHC three independent online luminosity measurement from the Pixel Luminosity Telescope (PLT), the Fast Beam Condition Monitor (BCM1F) and the Forward calorimeter (HF). The excellent performance of the BRIL detector front-ends, fast back-end electronics and CMS XDAQ based data processing and publication allow the use of emittance scans for linearity and stability studies of the luminometers. Emittance scans became a powerful tool and dramatically improved the understanding of the luminosity measurement during the year. Since each luminometer is independently calibrated in every scan the measurements are independent and ratios of luminometers ca...

Defect-induced wetting on BaF 2(111) and CaF 2(111) at ambient conditions

Science.gov (United States)

Cardellach, M.; Verdaguer, A.; Fraxedas, J.

2011-12-01

The interaction of water with freshly cleaved (111) surfaces of isostructural BaF2 and CaF2 single crystals at ambient conditions (room temperature and under controlled humidity) has been studied using scanning force microscopy in different operation modes and optical microscopy. Such surfaces exhibit contrasting behaviors for both materials: while on BaF2(111) two-dimensional water layers are formed after accumulation at step edges, CaF2(111) does not promote the formation of such layers. We attribute such opposed behavior to lattice match (mismatch) between hexagonal water ice and the hexagonal (111) surfaces of BaF2(CaF2). Optical microscope images reveal that this behavior also determines the way the surfaces become wetted at a macroscopic level.

''1/f noise'' in music: Music from 1/f noise

Energy Technology Data Exchange (ETDEWEB)

Voss, R.F.; Clarke, J.

1978-01-01

The spectral density of fluctuations in the audio power of many musical selections and of English speech varies approximately as 1/f (f is the frequency) down to a frequency of 5 x 10/sup -4/ Hz. This result implies that the audio-power fluctuations are correlated over all times in the same manner as ''1/f noise'' in electronic components. The frequency fluctuations of music also have a 1/f spectral density at frequencies down to the inverse of the length of the piece of music. The frequency fluctuations of English speech have a quite different behavior, with a single characteristic time of about 0.1 s, the average length of a syllable. The observations on music suggest that 1/f noise is a good choice for stochastic composition. Compositions in which the frequency and duration of each note were determined by 1/f noise sources sounded pleasing. Those generated by white-noise sources sounded too random, while those generated by 1/f/sup 2/ noise sounded too correlated.

HYPERDIRE. HYPERgeometric functions DIfferential REduction. MATHEMATICA based packages for differential reduction of generalized hypergeometric functions pFp-1, F1, F2, F3, F4

International Nuclear Information System (INIS)

Bytev, Vladimir V.; Kalmykov, Mikhail Yu.; Kniehl, Bernd A.

2013-05-01

HYPERDIRE is a project devoted to the creation of a set of Mathematica based programs for the differential reduction of hypergeometric functions. The current version includes two parts: one, pfq, is relevant for manipulations of hypergeometric functions p+1 F p , and the second one, AppellF1F4, for manipulations with Appell hypergeometric functions F 1 , F 2 , F 3 , F 4 of two variables.

Instantaneous angular speed monitoring of gearboxes under non-cyclic stationary load conditions

Science.gov (United States)

Stander, C. J.; Heyns, P. S.

2005-07-01

Recent developments in the condition monitoring and asset management market have led to the commercialisation of online vibration-monitoring systems. These systems are primarily utilised to monitor large mineral mining equipment such as draglines, continuous miners and hydraulic shovels. Online monitoring systems make diagnostic information continuously available for asset management, production outsourcing and maintenance alliances with equipment manufacturers. However, most online vibration-monitoring systems are based on conventional vibration-monitoring technologies, which are prone to giving false equipment deterioration warnings on gears that operate under fluctuating load conditions. A simplified mathematical model of a gear system was developed to illustrate the feasibility of monitoring the instantaneous angular speed (IAS) as a means of monitoring the condition of gears that are subjected to fluctuating load conditions. A distinction is made between cyclic stationary load modulation and non-cyclic stationary load modulation. It is shown that rotation domain averaging will suppress the modulation caused by non-cyclic stationary load conditions but will not suppress the modulation caused by cyclic stationary load conditions. An experimental investigation on a test rig indicated that the IAS of a gear shaft could be monitored with a conventional shaft encoder to indicate a deteriorating gear fault condition.

Aging, condition monitoring, and loss-of-coolant accident (LOCA) tests of class 1E electrical cables

International Nuclear Information System (INIS)

Jacobus, M.J.

1992-11-01

This report describes the results of aging, condition monitoring, and accident testing of miscellaneous cable types. Three sets of cables were aged for up to 9 months under simultaneous thermal (≅100 degrees C) and radiation (≅0.10 kGy/hr) conditions. A sequential accident consisting of high dose rate irradiation (≅6 kGy/hr) and high temperature steam followed the aging. Also exposed to the accident conditions was a fourth set of cables, which were unaged. The test results indicate that, properly installed, most of the various miscellaneous cable products tested should be able to survive an accident after 60 years for total aging doses of at least 150 kGy or higher (depending on the material) and for moderate ambient temperatures on the order of 45--55 degrees C (potentially higher or lower, depending on material specific activtion energies and total radiation doses). Mechanical measurements (primarily elongation, modulus, and density) were more effective than electrical measurements for monitoring age-related degradation

Tools and techniques for ageing predictions in nuclear reactors through condition monitoring

International Nuclear Information System (INIS)

Verma, R.M.P.

1994-01-01

To operate the nuclear reactors beyond their design predicted life is gaining importance because of huge replacement and decommissioning costs. But experience shows that nuclear plant safety and reliability may decline in the later years of plant life due to ageing degradation. Ageing of nuclear plant components, structures and systems, if unmitigated reduces their safety margins provided in the design and thus increases risks to public health and safety. These safety margins must be monitored throughout plant service life including any extended life. Condition monitoring of nuclear reactor components/equipment and systems can be done to study the effect of ageing, status of safety margins and effect of corrective and mitigating actions taken. The tools and techniques of condition monitoring are also important in failure trending, predictive maintenance, evaluation of scheduled maintenance, in mitigation of ageing, life extension and reliability studies. (author). 1 fig., 1 annexure

The influence of the working conditions on the equilibrium factor F and the unattached fraction fp

International Nuclear Information System (INIS)

Streil, T.; Reichert, A.

1998-01-01

The influence is reported of working conditions on dose estimation, in particular the equilibrium factor and the unattached fraction. For instance in a cabinet-maker's shop the radon concentration is strongly influenced by the ventilation system. The F factor is affected by dust producing work processes. For a better knowledge of radon dosimetry, the unattached fraction of radon progeny has to be measured continuously and separately. Preliminary results are presented obtained with a monitor containing three alpha detector microsystems measuring radon in the air, attached radon daughters and unattached radon daughters. The system was tested in buildings, caves, mines, waterworks and other places

Anesthesia condition for 18F-FDG imaging of lung metastasis tumors using small animal PET

International Nuclear Information System (INIS)

Woo, Sang-Keun; Lee, Tae Sup; Kim, Kyeong Min; Kim, June-Youp; Jung, Jae Ho; Kang, Joo Hyun; Cheon, Gi Jeong; Choi, Chang Woon; Lim, Sang Moo

2008-01-01

Small animal positron emission tomography (PET) with 18 F-FDG has been increasingly used for tumor imaging in the murine model. The aim of this study was to establish the anesthesia condition for imaging of lung metastasis tumor using small animal 18 F-FDG PET. Methods: To determine the impact of anesthesia on 18 F-FDG distribution in normal mice, five groups were studied under the following conditions: no anesthesia, ketamine and xylazine (Ke/Xy), 0.5% isoflurane (Iso 0.5), 1% isoflurane (Iso 1) and 2% isoflurane (Iso 2). The ex vivo counting, standard uptake value (SUV) image and glucose SUV of 18 F-FDG in various tissues were evaluated. The 18 F-FDG images in the lung metastasis tumor model were obtained under no anesthesia, Ke/Xy and Iso 0.5, and registered with CT image to clarify the tumor region. Results: Blood glucose concentration and muscle uptake of 18 F-FDG in the Ke/Xy group markedly increased more than in the other groups. The Iso 2 group increased 18 F-FDG uptake in heart compared with the other groups. The Iso 0.5 anesthesized group showed the lowest 18 F-FDG uptake in heart and chest wall. The small size of lung metastasis tumor (2 mm) was clearly visualized by 18 F-FDG image with the Iso 0.5 anesthesia. Conclusion: Small animal 18 F-FDG PET imaging with Iso 0.5 anesthesia was appropriate for the detection of lung metastasis tumor. To acquire 18 F-FDG PET images with small animal PET, the type and level of anesthetic should be carefully considered to be suitable for the visualization of target tissue in the experimental model

26 CFR 1.860F-1 - Qualified liquidations.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Qualified liquidations. 1.860F-1 Section 1.860F-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Real Estate Investment Trusts § 1.860F-1 Qualified liquidations. A plan of...

Condition Monitoring for DC-link Capacitors Based on Artificial Neural Network Algorithm

DEFF Research Database (Denmark)

Soliman, Hammam Abdelaal Hammam; Wang, Huai; Gadalla, Brwene Salah Abdelkarim

2015-01-01

hardware will reduce the cost, and therefore could be more promising for industry applications. A condition monitoring method based on Artificial Neural Network (ANN) algorithm is therefore proposed in this paper. The implementation of the ANN to the DC-link capacitor condition monitoring in a back......In power electronic systems, capacitor is one of the reliability critical components . Recently, the condition monitoring of capacitors to estimate their health status have been attracted by the academic research. Industry applications require more reliable power electronics products...... with preventive maintenance. However, the existing capacitor condition monitoring methods suffer from either increased hardware cost or low estimation accuracy, being the challenges to be adopted in industry applications. New development in condition monitoring technology with software solutions without extra...

Electric machines modeling, condition monitoring, and fault diagnosis

CERN Document Server

Toliyat, Hamid A; Choi, Seungdeog; Meshgin-Kelk, Homayoun

2012-01-01

With countless electric motors being used in daily life, in everything from transportation and medical treatment to military operation and communication, unexpected failures can lead to the loss of valuable human life or a costly standstill in industry. To prevent this, it is important to precisely detect or continuously monitor the working condition of a motor. Electric Machines: Modeling, Condition Monitoring, and Fault Diagnosis reviews diagnosis technologies and provides an application guide for readers who want to research, develop, and implement a more effective fault diagnosis and condi

Pump failure leads to alternative vertical pump condition monitoring technique

International Nuclear Information System (INIS)

DeVilliers, Adriaan; Glandon, Kevin

2011-01-01

Condition monitoring and detecting early signs of potential failure mechanisms present particular problems in vertical pumps. Most often, the majority of the pump assembly is not readily accessible for visual or audible inspection or conventional vibration monitoring techniques using accelerometers and/or proximity sensors. The root cause failure analysis of a 2-stage vertical centrifugal service-water pump at a nuclear power generating facility in the USA is presented, highlighting this long standing challenge in condition monitoring of vertical pumps. This paper will summarize the major findings of the root cause analysis (RCA), highlight the limitations of traditional monitoring techniques, and present an expanded application of motor current monitoring as a means to gain insight into the mechanical performance and condition of a pump. The 'real-world' example of failure, monitoring and correlation of the monitoring technique to a detailed pump disassembly inspection is also presented. This paper will explain some of the reasons behind well known design principles requiring natural frequency separation from known forcing frequencies, as well as explore an unexpected submerged brittle fracture failure mechanism, and how such issues may be avoided. (author)

The role of energy conditions in f(R) cosmology

Science.gov (United States)

Capozziello, S.; Nojiri, S.; Odintsov, S. D.

2018-06-01

Energy conditions can play an important role in defining the cosmological evolution. Specifically acceleration/deceleration of cosmic fluid, as well as the emergence of Big Rip singularities, can be related to the constraints imposed by the energy conditions. Here we discuss this issue for f (R) gravity considering also conformal transformations. Cosmological solutions and equations of state can be classified according to energy conditions. The qualitative change of some energy conditions when transformation from the Jordan frame to the Einstein frame done is also observed.

Contrast normalization contributes to a biologically-plausible model of receptive-field development in primary visual cortex (V1)

Science.gov (United States)

Willmore, Ben D.B.; Bulstrode, Harry; Tolhurst, David J.

2012-01-01

Neuronal populations in the primary visual cortex (V1) of mammals exhibit contrast normalization. Neurons that respond strongly to simple visual stimuli – such as sinusoidal gratings – respond less well to the same stimuli when they are presented as part of a more complex stimulus which also excites other, neighboring neurons. This phenomenon is generally attributed to generalized patterns of inhibitory connections between nearby V1 neurons. The Bienenstock, Cooper and Munro (BCM) rule is a neural network learning rule that, when trained on natural images, produces model neurons which, individually, have many tuning properties in common with real V1 neurons. However, when viewed as a population, a BCM network is very different from V1 – each member of the BCM population tends to respond to the same dominant features of visual input, producing an incomplete, highly redundant code for visual information. Here, we demonstrate that, by adding contrast normalization into the BCM rule, we arrive at a neurally-plausible Hebbian learning rule that can learn an efficient sparse, overcomplete representation that is a better model for stimulus selectivity in V1. This suggests that one role of contrast normalization in V1 is to guide the neonatal development of receptive fields, so that neurons respond to different features of visual input. PMID:22230381

Larval development of Spodoptera eridania and Spodoptera frugiperda fed on fresh ear of field corn expressing the Bt proteins (Cry1F and Cry1F + Cry1A.105 + Cry2Ab2

Directory of Open Access Journals (Sweden)

Orcial Ceolin Bortolotto

Full Text Available ABSTRACT: The objective of this study was to evaluate extent of larval period, larval survival (%, food consumption, and pupal biomass of Spodoptera eridania and Spodoptera frugiperda (Lepidoptera: Noctuidae fed on fresh ears of field corn expressing Bt proteins (Cry1F and Cry1F+Cry1A.105+Cry2Ab2. Larvae of Spodoptera spp. survived less than two days when they consumed Bt corncobs and showed 100% mortality. Spodoptera eridania reared on non-Bt corn cobs showed higher larval development (21.6 days than S. frugiperda (18.4 days and lower viability (56.4% and 80.2% for S. eridania and S. frugiperda , respectively. A higher amount of corn grains was consumed by S. eridania (5.4g than by S. frugiperda (3.9g. In summary, this study demonstrated that the toxins Cry1F and Cry1F + Cry1A.105 + Cry2Ab2 expressed in fresh corn cobs contributed to protect ears of corn against S. frugiperda and the non-target pest S. eridania . However, itis important to monitor non-Bt cornfields because of the potential of both species to cause damage to ear sof corn.

Gamma ampersand beta-gamma storm water monitor operability

International Nuclear Information System (INIS)

Tshiskiku, E.M.

1993-01-01

High Level Waste (HLW) facilities have nine storm water monitors that monitor storm water run off from different process areas for Cesium 137, a Gamma emitter. F - Area has three monitors: 907-2F, 907-3F and 907-4F while H - Area has six monitors: 907-2H, 907-3H, 907-4H, 907-5H, 907-6H and 907-7H (See attachments number-sign 1, number-sign 2 and number-sign 3 for location). In addition to monitoring for Cesium, 907-6H and 907-7H monitor for Strontium-90, a Beta emitter. Each monitor is associated with one of the following diversion gate encasements 907-1H, 241-15H, 241-51H, 907-1F or 241-23F. Normal flow of storm water from these diversion gate encasements is to the Four Mile Creek. When a storm water monitor detects radioactivity at a level exceeding the Four Mile Creek discharge limit, the monitor causes repositioning of the associated diversion gate to discharge to the H - Area retention basin 281-8H or the F - Area retention basin 281-8F. In response to recent OSR interpretation of storm water monitor calibration requirements, this report is provided to document operability and accuracy of radiation detection

Integrating structural health and condition monitoring

DEFF Research Database (Denmark)

May, Allan; Thöns, Sebastian; McMillan, David

2015-01-01

window’ allowing for the possible detection of faults up to 6 months in advance. The SHM system model uses a reduction in the probability of failure factor to account for lower modelling uncertainties. A case study is produced that shows a reduction in operating costs and also a reduction in risk......There is a large financial incentive to minimise operations and maintenance (O&M) costs for offshore wind power by optimising the maintenance plan. The integration of condition monitoring (CM) and structural health monitoring (SHM) may help realise this. There is limited work on the integration...

Electrical condition monitoring method for polymers

Science.gov (United States)

Watkins, Jr. Kenneth S.; Morris, Shelby J.; Masakowski, Daniel D.; Wong, Ching Ping; Luo, Shijian

2010-02-16

An electrical condition monitoring method utilizes measurement of electrical resistivity of a conductive composite degradation sensor to monitor environmentally induced degradation of a polymeric product such as insulated wire and cable. The degradation sensor comprises a polymeric matrix and conductive filler. The polymeric matrix may be a polymer used in the product, or it may be a polymer with degradation properties similar to that of a polymer used in the product. The method comprises a means for communicating the resistivity to a measuring instrument and a means to correlate resistivity of the degradation sensor with environmentally induced degradation of the product.

The ToF-ACSM: a portable aerosol chemical speciation monitor with TOFMS detection

Directory of Open Access Journals (Sweden)

R. Fröhlich

2013-11-01

Full Text Available We present a new instrument for monitoring aerosol composition, the time-of-flight aerosol chemical speciation monitor (ToF-ACSM, combining precision state-of-the-art time-of-flight mass spectrometry with stability, reliability, and easy handling, which are necessities for long-term monitoring operations on the scale of months to years. Based on Aerodyne aerosol mass spectrometer (AMS technology, the ToF-ACSM provides continuous online measurements of chemical composition and mass of non-refractory submicron aerosol particles. In contrast to the larger AMS, the compact-sized and lower-priced ToF-ACSM does not feature particle sizing, similar to the widely-used quadrupole-ACSM (Q-ACSM. Compared to the Q-ACSM, the ToF-ACSM features a better mass resolution of M/ΔM = 600 and better detection limits on the order of −3 for a time resolution of 30 min. With simple upgrades these limits can be brought down by another factor of ~ 8. This allows for operation at higher time resolutions and in low concentration environments. The associated software packages (single packages for integrated operation and calibration and analysis provide a high degree of automation and remote access, minimising the need for trained personnel on site. Intercomparisons with Q-ACSM, C-ToF-AMS, nephelometer and scanning mobility particle sizer (SMPS measurements, performed during a first long-term deployment (> 10 months on the Jungfraujoch mountain ridge (3580 m a.s.l. in the Swiss Alps, agree quantitatively. Additionally, the mass resolution of the ToF-ACSM is sufficient for basic mass defect resolved peak fitting of the recorded spectra, providing a data stream not accessible to the Q-ACSM. This allows for quantification of certain hydrocarbon and oxygenated fragments (e.g. C3H7+ and C2H3O+, both occurring at m/Q = 43 Th, as well as improving inorganic/organic separation.

Optimization of Remediation Conditions using Vadose Zone Monitoring Technology

Science.gov (United States)

Dahan, O.; Mandelbaum, R.; Ronen, Z.

2010-12-01

irrigation system to enrich the percolating water. The vadose zone monitoring system that was installed at the site allowed accurate monitoring of the wetting cycles, including: (1) wetting front propagation velocities, (2) temporal variation of the sediment water content, (2) chemical composition of the percolating water, (3) isotopic composition of BTEX compounds, (4) variations in nutrient concentration, and (5) variations in the vadose zone redox potential. Preliminary results showed that the wetting front crossed the entire vadose zone in four days reaching maximum water content values of 12 to 18 %. Temporal variation in the sediment BTEX concentrations indicated significant reduction in highly soluble and mobile compounds such as MTBE. Yet the chemical composition of the water samples through the first sampling campaign indicated that the limiting factor for biodegradation at the first wetting cycle was insufficient nitrogen. Results from each wetting cycles were used to improve the following wetting cycles in order to optimize the vadose zone conditions for microbial activity while minimizing leaching of contaminants to the groundwater.

The ATLAS beam conditions monitor

CERN Document Server

Mikuz, M; Dolenc, I; Kagan, H; Kramberger, G; Frais-Kölbl, H; Gorisek, A; Griesmayer, E; Mandic, I; Pernegger, H; Trischuk, W; Weilhammer, P; Zavrtanik, M

2006-01-01

The ATLAS beam conditions monitor is being developed as a stand-alone device allowing to separate LHC collisions from background events induced either on beam gas or by beam accidents, for example scraping at the collimators upstream the spectrometer. This separation can be achieved by timing coincidences between two stations placed symmetric around the interaction point. The 25 ns repetition of collisions poses very stringent requirements on the timing resolution. The optimum separation between collision and background events is just 12.5 ns implying a distance of 3.8 m between the two stations. 3 ns wide pulses are required with 1 ns rise time and baseline restoration in 10 ns. Combined with the radiation field of 10/sup 15/ cm/sup -2/ in 10 years of LHC operation only diamond detectors are considered suitable for this task. pCVD diamond pad detectors of 1 cm/sup 2/ and around 500 mum thickness were assembled with a two-stage RF current amplifier and tested in proton beam at MGH, Boston and SPS pion beam at...

Monitoring Thermal Conditions in Footwear

Science.gov (United States)

Silva-Moreno, Alejandra. A.; Lopez Vela, Martín; Alcalá Ochoa, Noe

2006-09-01

Thermal conditions inside the foot were evaluated on a volunteer subject. We have designed and constructed an electronic system which can monitors temperature and humidity of the foot inside the shoe. The data is stored in a battery-powered device for later uploading to a host computer for data analysis. The apparatus potentially can be used to provide feedback to patients who are prone to having skin breakdowns.

Transformer ageing modern condition monitoring techniques and their interpretations

CERN Document Server

Purkait, Prithwiraj

2017-01-01

This book is a one-stop guide to state-of-the-art research in transformer ageing, condition monitoring and diagnosis. It is backed by rigorous research projects supported by the Australian Research Council in collaboration with several transmission and distribution companies. Many of the diagnostic techniques and tools developed in these projects have been applied by electricity utilities and would appeal to both researchers and practicing engineers. Important topics covered in this book include transformer insulation materials and their ageing behaviour, transformer condition monitoring techniques and detailed diagnostic techniques and their interpretation schemes. It also features a monitoring framework for smart transformers as well as a chapter on biodegradable oil.

Energy conditions in f(G,T) gravity

Energy Technology Data Exchange (ETDEWEB)

Sharif, M.; Ikram, Ayesha [University of the Punjab, Department of Mathematics, Lahore (Pakistan)

2016-11-15

The aim of this paper is to introduce a new modified gravity theory named f(G,T) gravity (G and T are the Gauss-Bonnet invariant and trace of the energy-momentum tensor, respectively) and investigate energy conditions for two reconstructed models in the context of FRW universe. We formulate general field equations, divergence of energy-momentum tensor, equation of motion for test particles as well as corresponding energy conditions. The massive test particles follow non-geodesic lines of geometry due to the presence of an extra force. We express the energy conditions in terms of cosmological parameters like the deceleration, jerk, and snap parameters. The reconstruction technique is applied to this theory using de Sitter and power-law cosmological solutions. We analyze the energy bounds and obtain feasible constraints on the free parameters. (orig.)

10 CFR 20.1502 - Conditions requiring individual monitoring of external and internal occupational dose.

Science.gov (United States)

2010-01-01

... external and internal occupational dose. Each licensee shall monitor exposures to radiation and radioactive... 10 Energy 1 2010-01-01 2010-01-01 false Conditions requiring individual monitoring of external and internal occupational dose. 20.1502 Section 20.1502 Energy NUCLEAR REGULATORY COMMISSION STANDARDS FOR...

F F1-ATPase as biosensor to detect single virus

International Nuclear Information System (INIS)

Liu, XiaoLong; Zhang, Yun; Yue, JiaChang; Jiang, PeiDong; Zhang, ZhenXi

2006-01-01

F F 1 -ATPase within chromatophore was constructed as a biosensor (immuno-rotary biosensor) for the purpose of capturing single virus. Capture of virus was based on antibody-antigen reaction. The detection of virus based on proton flux change driven by ATP-synthesis of F F 1 -ATPase, which was indicated by F1300, was directly observed by a fluorescence microscope. The results demonstrate that the biosensor loading of virus particles has remarkable signal-to-noise ratio (3.8:1) compared to its control at single molecular level, and will be convenient, quick, and even super-sensitive for detecting virus particles

Nanoelectrospray with ion-trap mass spectrometry for the determination of beta-casomorphins in derived milk products.

Science.gov (United States)

Juan-García, Ana; Font, Guillermina; Juan, Cristina; Picó, Yolanda

2009-11-15

Beta-casomorphins (b-CMs) are bioactive peptides derived from casein with opioid agonist effects similar to morphine. The use of electrospray (ESI) with quadrupole ion-trap mass spectrometry (QIT-MS) for these compounds in two matrices, cheese and milk, was examined. It was compared to a liquid chromatography (LC) coupled to mass spectrometry (LC-MS), and a "soft" ionisation technique, NanoMate, with selected ion monitoring (SIM), which are unreliable for the determination of trace casomorphins in derived milk products. b-CM mass fragmentation pathways were done for the four most common b-CMs: beta-casomorphin (1-5) bovine (b-CM-5), beta-casomorphin (1-7) bovine (b-CM-7), [D-Ala2, D-Pro4,Tyr5]-beta-casomorphin (1-5) amide (b-CM-10) and beta-casomorphin (1-5) amide [D-Ala2,Hyp4,Tyr5] (b-CM-11). The major product ions obtained in QIT-MS were used to construct fragmentation pathways for b-CMs. The different collision energies using automated nanoelectrospray ion source NanoMate and conventional LC in QIT-MS were studied. Calibration data for b-CMs, using spiked milk or cheese samples (10 g or 10 mL), were: NanoMate/MS (25-1000 microg/L), r(2)=0.998; NanoMate/MS(2) (5-1000 microg/L), r(2)=0.9992; NanoMate/MS(3) (2.5-1000 microg/L), r(2)=0.9998. Reproducibility data (% RSD, N=5) for NanoMate/MS(n) mode ranged between 2.0 at 500 microg/L and 7.0 at 10 microg/L.

Self-dose and fading of CaSO4(Dy/Tm) and CaF2 (natural) TL phosphors in environmental radiation monitoring

International Nuclear Information System (INIS)

Nambi, K.S.V.

1982-01-01

A 'shielded storage experiment' for estimating both the 'self-dose' and 'fading' of TL phosphors under conditions akin to those faced in environmental monitoring applications is described. Using this method, self-dose rates of 0.32 +- 0.10(sigma) μ rad h -1 and 1.16 +- 0.02(sigma) μ rad h -1 have been obtained for CaF 2 (natural) and CaSO 4 (Dy) phosphors; the thermal decay constants at 25 0 C for these phosphors turn out to be 27 X 10 -6 h -6 ad 12 X 10 -6 h -1 , respectively. Estimation of the self-doses from radioactivity measurements of the phosphors concerned is also presented and the differences explained. A very high self-dose rate of 5.6 μ rad h -1 was estimated by the latter method for a sample of CaSO 4 (Tm) phosphor. (orig.)

Condition Monitoring of Machinery in Non-Stationary Operations : Proceedings of the Second International Conference "Condition Monitoring of Machinery in Non-Stationnary Operations"

CERN Document Server

Bartelmus, Walter; Chaari, Fakher; Zimroz, Radoslaw; Haddar, Mohamed

2012-01-01

Condition monitoring of machines in non-stationary operations (CMMNO) can be seen as the major challenge for research in the field of machinery diagnostics. Condition monitoring of machines in non-stationary operations is the title of the presented book and the title of the Conference held in Hammamet - Tunisia March 26 – 28, 2012. It is the second conference under this title, first took place in Wroclaw - Poland , March 2011. The subject CMMNO comes directly from industry needs and observation of real objects. Most monitored and diagnosed objects used in industry works in non-stationary operations condition. The non-stationary operations come from fulfillment of machinery tasks, for which they are designed for. All machinery used in different kind of mines, transport systems, vehicles like: cars, buses etc, helicopters, ships and battleships and so on work in non-stationary operations. The papers included in the book are shaped by the organizing board of the conference and authors of the papers. The papers...

The use of condition monitoring information for maintenance planning and decision-making

Energy Technology Data Exchange (ETDEWEB)

Laakso, K.; Rosqvist, T. [VTT Industrial Systems (Finland); Paulsen, J.L. [Risoe National Lab., Roskilde (Denmark)

2002-12-01

A survey is presented outlining the use of condition monitoring information in three Nordic nuclear power plants. The questions of the survey relate to the role of condition monitoring in strategic, as well as operative, maintenance planning and decision-making. The survey indicates that condition monitoring is increasingly implemented at nuclear power plants, but very selectively and in a rather slow pace for predictive maintenance. A combined strategy of condition based maintenance and predetermined preventive maintenance is applied for important equipment such as main circulation pumps and steam turbines. A realistic aim is to reduce the number of costly or error prone maintenance and disassembling inspection activities by condition monitoring given that the approach enables a good diagnosis and prediction. Systematic follow-up and analysis of such condition monitoring information followed by a case-specific planning and decision making of timely and rightly directed maintenance actions can justify an extension of the intervals of a number of predetermined inspection, maintenance or periodic testing tasks. (au)

On the identification of fractionally cointegrated VAR models with the F(d) condition

DEFF Research Database (Denmark)

Carlini, Federico; Santucci de Magistris, Paolo

with different fractional integration and cointegration parameters. The properties of these multiple non-identified sub-models are studied and a necessary and sufficient condition for the identification of the fractional parameters of the system is provided. The condition is named F(d). The assessment of the F(d...

HYPERDIRE. HYPERgeometric functions DIfferential REduction. MATHEMATICA based packages for differential reduction of generalized hypergeometric functions {sub p}F{sub p-1}, F{sub 1}, F{sub 2}, F{sub 3}, F{sub 4}

Energy Technology Data Exchange (ETDEWEB)

Bytev, Vladimir V.; Kalmykov, Mikhail Yu. [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik; Joint Institute for Nuclear Research, Dubna (Russian Federation); Kniehl, Bernd A. [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik

2013-05-15

HYPERDIRE is a project devoted to the creation of a set of Mathematica based programs for the differential reduction of hypergeometric functions. The current version includes two parts: one, pfq, is relevant for manipulations of hypergeometric functions {sub p+1}F{sub p}, and the second one, AppellF1F4, for manipulations with Appell hypergeometric functions F{sub 1}, F{sub 2}, F{sub 3}, F{sub 4} of two variables.

Significance of Operating Environment in Condition Monitoring of Large Civil Structures

Directory of Open Access Journals (Sweden)

Sreenivas Alampalli

1999-01-01

Full Text Available Success of remote long-term condition monitoring of large civil structures and developing calibrated analytical models for damage detection, depend significantly on establishing accurate baseline signatures and their sensitivity. Most studies reported in the literature concentrated on the effect of structural damage on modal parameters without emphasis on reliability of modal parameters. Thus, a field bridge structure was studied for the significance of operating conditions in relation to baseline signatures. Results indicate that in practice, civil structures should be monitored for at least one full cycle of in-service environmental changes before establishing baselines for condition monitoring or calibrating finite-element models. Boundary conditions deserve special attention.

GEOGLAM Crop Monitor Assessment Tool: Developing Monthly Crop Condition Assessments

Science.gov (United States)

McGaughey, K.; Becker Reshef, I.; Barker, B.; Humber, M. L.; Nordling, J.; Justice, C. O.; Deshayes, M.

2014-12-01

The Group on Earth Observations (GEO) developed the Global Agricultural Monitoring initiative (GEOGLAM) to improve existing agricultural information through a network of international partnerships, data sharing, and operational research. This presentation will discuss the Crop Monitor component of GEOGLAM, which provides the Agricultural Market Information System (AMIS) with an international, multi-source, and transparent consensus assessment of crop growing conditions, status, and agro-climatic conditions likely to impact global production. This activity covers the four primary crop types (wheat, maize, rice, and soybean) within the main agricultural producing regions of the AMIS countries. These assessments have been produced operationally since September 2013 and are published in the AMIS Market Monitor Bulletin. The Crop Monitor reports provide cartographic and textual summaries of crop conditions as of the 28th of each month, according to crop type. This presentation will focus on the building of international networks, data collection, and data dissemination.

Wireless pilot monitoring system for extreme race conditions.

Science.gov (United States)

Pino, Esteban J; Arias, Diego E; Aqueveque, Pablo; Melin, Pedro; Curtis, Dorothy W

2012-01-01

This paper presents the design and implementation of an assistive device to monitor car drivers under extreme conditions. In particular, this system is designed in preparation for the 2012 Atacama Solar Challenge to be held in the Chilean desert. Actual preliminary results show the feasibility of such a project including physiological and ambient sensors, real-time processing algorithms, wireless data transmission and a remote monitoring station. Implementation details and field results are shown along with a discussion of the main problems found in real-life telemetry monitoring.

Anesthesia condition for {sup 18}F-FDG imaging of lung metastasis tumors using small animal PET

Energy Technology Data Exchange (ETDEWEB)

Woo, Sang-Keun; Lee, Tae Sup; Kim, Kyeong Min; Kim, June-Youp; Jung, Jae Ho; Kang, Joo Hyun [Division of Nuclear Medicine and RI Application, Korea Institute of Radiological and Medical Sciences (KIRAMS), Nowon-Gu, Seoul 139-706 (Korea, Republic of); Cheon, Gi Jeong [Division of Nuclear Medicine and RI Application, Korea Institute of Radiological and Medical Sciences (KIRAMS), Nowon-Gu, Seoul 139-706 (Korea, Republic of); Department of Nuclear Medicine, Korea Institute of Radiological and Medical Sciences (KIRAMS), Nowon-Gu, Seoul 139-706 (Korea, Republic of)], E-mail: larry@kcch.re.kr; Choi, Chang Woon; Lim, Sang Moo [Division of Nuclear Medicine and RI Application, Korea Institute of Radiological and Medical Sciences (KIRAMS), Nowon-Gu, Seoul 139-706 (Korea, Republic of); Department of Nuclear Medicine, Korea Institute of Radiological and Medical Sciences (KIRAMS), Nowon-Gu, Seoul 139-706 (Korea, Republic of)

2008-01-15

Small animal positron emission tomography (PET) with {sup 18}F-FDG has been increasingly used for tumor imaging in the murine model. The aim of this study was to establish the anesthesia condition for imaging of lung metastasis tumor using small animal {sup 18}F-FDG PET. Methods: To determine the impact of anesthesia on {sup 18}F-FDG distribution in normal mice, five groups were studied under the following conditions: no anesthesia, ketamine and xylazine (Ke/Xy), 0.5% isoflurane (Iso 0.5), 1% isoflurane (Iso 1) and 2% isoflurane (Iso 2). The ex vivo counting, standard uptake value (SUV) image and glucose SUV of {sup 18}F-FDG in various tissues were evaluated. The {sup 18}F-FDG images in the lung metastasis tumor model were obtained under no anesthesia, Ke/Xy and Iso 0.5, and registered with CT image to clarify the tumor region. Results: Blood glucose concentration and muscle uptake of {sup 18}F-FDG in the Ke/Xy group markedly increased more than in the other groups. The Iso 2 group increased {sup 18}F-FDG uptake in heart compared with the other groups. The Iso 0.5 anesthesized group showed the lowest {sup 18}F-FDG uptake in heart and chest wall. The small size of lung metastasis tumor (2 mm) was clearly visualized by {sup 18}F-FDG image with the Iso 0.5 anesthesia. Conclusion: Small animal {sup 18}F-FDG PET imaging with Iso 0.5 anesthesia was appropriate for the detection of lung metastasis tumor. To acquire {sup 18}F-FDG PET images with small animal PET, the type and level of anesthetic should be carefully considered to be suitable for the visualization of target tissue in the experimental model.

Efficient automated synthesis of 2-(5-["1"8F]fluoropentyl)-2-methylmalonic acid (["1"8F]ML-10) on a commercial available ["1"8F]FDG synthesis module

International Nuclear Information System (INIS)

Liu, Shaoyu; Nie, Dahong; Jiang, Shende; Tang, Ganghua

2017-01-01

["1"8F]ML-10 (2-(5-["1"8F]fluoro-pentyl)-2-methylmalonic acid) is a small molecule positron emission tomography (PET) probe for apoptosis imaging. Automated synthesis of ["1"8F]ML-10 was developed by using two different purification methods through a direct saponification procedure on a modified commercial ["1"8F]Fluoro-2-Deoxyglucose (["1"8F]FDG) synthesizer. C18 purification method 1: The final ["1"8F]ML-10 solution containing ethanol was obtained with radiochemical yields of 60±5% (n=5) at the end of bombardment (EOB) and radiochemical purity of 98% in 35 min. Al_2O_3 and SCX purification method 2: To avoid possible side effects of a conventional ethanol-containing formulation, an new ethanol-free solution of ["1"8F]ML-10 was also developed, the radiochemical yields was 50±5% (n=5, EOB) within 45 min and the radiochemical purity was 98%. - Highlights: • The production of ["1"8F]ML-10 was optimized by using a straightforward saponification procedure. • Automated synthesis was performed on a commonly FDG synthesis module. • An ethanol-containing ["1"8F]ML-10 formulation was obtained with high radiochemical yield in a shorter time. • An ethanol-free formulation method of ["1"8F]ML-10 was also developed.

Recommendations for strengthening the infrared technology component of any condition monitoring program

Science.gov (United States)

Nicholas, Jack R., Jr.; Young, R. K.

1999-03-01

This presentation provides insights of a long term 'champion' of many condition monitoring technologies and a Level III infra red thermographer. The co-authors present recommendations based on their observations of infra red and other components of predictive, condition monitoring programs in manufacturing, utility and government defense and energy activities. As predictive maintenance service providers, trainers, informal observers and formal auditors of such programs, the co-authors provide a unique perspective that can be useful to practitioners, managers and customers of advanced programs. Each has over 30 years experience in the field of machinery operation, maintenance, and support the origins of which can be traced to and through the demanding requirements of the U.S. Navy nuclear submarine forces. They have over 10 years each of experience with programs in many different countries on 3 continents. Recommendations are provided on the following: (1) Leadership and Management Support (For survival); (2) Life Cycle View (For establishment of a firm and stable foundation for a program); (3) Training and Orientation (For thermographers as well as operators, managers and others); (4) Analyst Flexibility (To innovate, explore and develop their understanding of machinery condition); (5) Reports and Program Justification (For program visibility and continued expansion); (6) Commitment to Continuous Improvement of Capability and Productivity (Through application of updated hardware and software); (7) Mutual Support by Analysts (By those inside and outside of the immediate organization); (8) Use of Multiple Technologies and System Experts to Help Define Problems (Through the use of correlation analysis of data from up to 15 technologies. An example correlation analysis table for AC and DC motors is provided.); (9) Root Cause Analysis (Allows a shift from reactive to proactive stance for a program); (10) Master Equipment Identification and Technology Application (To

Implementation strategies and tools for condition based monitoring at nuclear power plants

International Nuclear Information System (INIS)

2007-05-01

There is now an acute need to optimize maintenance to improve both reliability and competitiveness of nuclear power plant operation. There is an increasing tendency to move from the preventive (time based) maintenance concept to one dependent on plant and component conditions. In this context, various on-line and off-line condition monitoring and diagnostics, nondestructive inspection techniques and surveillance are used. Component selection for condition based maintenance, parameter selection for monitoring condition, evaluation of condition monitoring results are issues influencing the effectiveness of condition based maintenance. All these selections of components and parameters to be monitored, monitoring and diagnostics techniques to be used, acceptance criteria and trending for condition evaluation, and the economic aspect of predictive maintenance and condition monitoring should be incorporated into an integrated, effective condition based maintenance programme, which is part of the plant's overall maintenance optimization programme. This publication collects and analyses proven condition based maintenance strategies and techniques (engineering and organizational) in Member States. It includes selected papers on maintenance optimization presented during its preparation. This report was prepared under IAEA project on integrated NPP life cycle management including decommissioning. The main objective of an integrated life cycle management programme is to enable NPP's to compete, without compromising safety, successfully in the changing energy markets throughout their service life and to facilitate life extension and eventual decommissioning through improved engineering, technological, economic and managerial actions. The technical working group on NPP life management and other advisory groups nominated by the Member States provide recommendations on high priority needs of Member States in this area

Practical synthesis of 1-(2-Nitro-1H-imidazol-1-yl)-3-(tosyloxy)propan-2-yl acetate for the radiosynthesis of [{sup 18}F]-FMISO

Energy Technology Data Exchange (ETDEWEB)

Kwon, Young Do; Lim, Seok Tae; Sohn, Myung Hee; Kim, Hee Kwon [Dept. of Nuclear Medicine, Molecular Imaging and Therapeutic Medicine Rese arch Center, CyclotronResearch Center, Biomedica l Research Institute, Chonbuk National University Medical School and Hospital,Jeonju (Korea, Republic of); Seol, Eun Taek; Lee, Seung Jae [Dept. of Chemistry and Research Institute of Physics and Chemistry, Chonbuk National University,Jeonju (Korea, Republic of); Jung, Yong Ju [Dept. of Chemistry Chemical Engineering, Korea University of Technology and Education (KOREATECH),Cheonan (Korea, Republic of)

2015-02-15

Hypoxia is related with many tumors due to a decreased oxygen condition. Novel synthesis for 1-(2-nitro-1H-imidazol-1-yl)-3-(tosyloxy)propan-2-yl acetate for the radiosynthesis of the [{sup 18}F]-Flouromisonidazole ([{sup 18}F]-FMISO), a hypoxia imaging marker used in positron emission tomography, from the readily available starting material is described. In this approach, one-pot two-step syntheses were used for the preparation of the [{sup 18}F]-FMISO precursors that contain acetyl group. The mild reaction conditions and easy treatments are attractive features in this synthesis. This new synthetic route provides alternative choices for the preparation of hypoxia imaging marker.

Noninvasive monitoring of cancer therapy induced activated T cells using [18F]FB-IL-2 PET imaging.

Science.gov (United States)

Hartimath, S V; Draghiciu, O; van de Wall, S; Manuelli, V; Dierckx, R A J O; Nijman, H W; Daemen, T; de Vries, E F J

2017-01-01

Cancer immunotherapy urgently calls for methods to monitor immune responses at the site of the cancer. Since activated T lymphocytes may serve as a hallmark for anticancer responses, we targeted these cells using the radiotracer N-(4-[ 18 F]fluorobenzoyl)-interleukin-2 ([ 18 F]FB-IL-2) for positron emission tomography (PET) imaging. Thus, we noninvasively monitored the effects of local tumor irradiation and/or immunization on tumor-infiltrating and systemic activated lymphocytes in tumor-bearing mice. A 10- and 27-fold higher [ 18 F]FB-IL-2 uptake was observed in tumors of mice receiving tumor irradiation alone or in combination with immunization, respectively. This increased uptake was extended to several non-target tissues. Administration of the CXCR4 antagonist AMD3100 reduced tracer uptake by 2.8-fold, indicating a CXCR4-dependent infiltration of activated T lymphocytes upon cancer treatment. In conclusion, [ 18 F]FB-IL-2 PET can serve as a clinical biomarker to monitor treatment-induced infiltration of activated T lymphocytes and, on that basis, may guide cancer immunotherapies.

Why is it important to monitor social conditions in wilderness?

Science.gov (United States)

Alan E. Watson

1990-01-01

“Social conditions in wilderness” refers to all aspects of human use of the wilderness that pose the possibility of impact to the resource and visitor experiences. The reasons for monitoring (1) use levels and use trends (including characteristics of use and users) and (2) the quality of the recreation experiences provided (ability to provide naturalness, privacy, and...

Uranium gastrointestinal absorption: the F1 factor in humans

International Nuclear Information System (INIS)

Zamora, M.L.; Zielinski, J.M.; Meyerhof, D.; Moodie, G.; Falcomer, R.; Tracy, B.

2003-01-01

The present investigation was undertaken by the Department of Health, Canada, to determine the most appropriate value to use for uranium gastrointestinal absorption (f 1 ) in setting the guideline for drinking water. Fifty participants, free from medical problems, were recruited from two communities: a rural area where drinking water, supplied from drilled wells, contained elevated levels of uranium and an urban area where the water supplied by the municipal water system contained -1 . Uranium intake through food, drinking water and other beverages was monitored using the duplicate diet approach. Intake and excretion were measured by inductively coupled plasma-mass spectrometry (ICP-MS) in samples collected concurrently from the same individuals over a 3 d period. The range of f 1 values was between 0.001 to 0.06, with a median of 0.009. These values were independent of gender, age, duration of exposure, daily total uranium intake and allocation of intake between food and water. Consistent with the recommendation of ICRP Publication 69, 78% were below 0.02. (author)

Complete lift of a structure satisfying FK−(−K+1F=0

Directory of Open Access Journals (Sweden)

Lovejoy S. Das

1992-01-01

Full Text Available The idea of f-structure manifold on a differentiable manifold was initiated and developed by Yano [1], Ishihara and Yano [2], Goldberg [3] and among others. The horizontal and complete lifts from a differentiable manifold Mn of class C∞ to its cotangent bundles have been studied by Yano and Patterson [4,5]. Yano and Ishihara [6] have studied lifts of an f-structure in the tangent and cotangent bundles. The purpose of this paper is to obtain integrability conditions of a structure satisfying FK−(−K+1F=0 and FW−(−W+1F≠0 for 1

In vivo and in vitro characterization of [18F]-FE-(+)-DTBZ as a tracer for beta-cell mass

International Nuclear Information System (INIS)

Eriksson, Olof; Jahan, Mahabuba; Johnstroem, Peter; Korsgren, Olle; Sundin, Anders; Halldin, Christer; Johansson, Lars

2010-01-01

Introduction: The positron emission tomography (PET) tracer 9-[ 18 F]fluoroethyl-(+)-dihydrotetrabenazine ([ 18 F]-FE-(+)-DTBZ) is a potential candidate for quantifying beta-cell mass in vivo. The purpose was to investigate in vitro and in vivo utility of this tracer for the assessment of beta-cell mass. Methods: Three pigs were intravenously administered [ 18 F]-FE-(+)-DTBZ and examined by PET/computed tomography. Binding parameters were estimated by kinetic modeling. In vitro k D and B max were determined by saturation binding studies of endocrine and exocrine human tissue homogenates. In vitro pancreatic uptake was determined by tissue autoradiography with pancreases from patients with types 1 (T1DM) and 2 diabetes mellitus (T2DM) and healthy controls. Results: [ 18 F]-FE-(+)-DTBZ had a k D of 3.5±1.0 nM, a B max of 382±108 fmol/mg protein and a specificity of 89±1.8% in islet homogenates. The total exocrine uptake was lower and 65% was nondisplaceable. No uptake difference was observed in pancreatic tissue slices from patients with T1DM, T2DM or healthy controls. The in vivo porcine pancreatic uptake reached a peak of standardized uptake value (SUV) of 2.8 with a low distribution volume ratio in all animals. Moderate to high tracer uptake was identified in the bile system and in bone. Conclusions: [ 18 F]-FE-(+)-DTBZ binds to vesicular monoamine transporter 2 (VMAT2) with high specificity in pure islet tissue in vitro. However, there is high nondisplaceable binding to exocrine tissue. In addition, in vivo tracer metabolism and dehalogenation result in severe underestimation of porcine pancreatic VMAT2 expression and BCM. The results do not support [ 18 F]-FE-(+)-DTBZ as a suitable tracer for in vivo beta-cell imaging.

Monitoring and analysis of an absorption air-conditioning system

Energy Technology Data Exchange (ETDEWEB)

Perez de Vinaspre, M.; Bourouis, M.; Coronas, A. [Centro de Innovacion Tecnologica en Revalorizacion Energetica y Refrigeracion, Tarragona (Spain); Garcia, A.; Soto, V.; Pinazo, J.M. [E.T.S. Ingenieros Industriales, Valencia (Spain)

2004-09-01

In the last few years, high-energy consumption due to air-conditioning has led to a growing interest in the efficient use of energy in buildings. Although simulation programs have always been the main tools for analyzing energy in buildings, the reliability of their results is often compromised by a lack of certainty to reflect real conditions. The aim of this work is to monitorize and analyze the thermal behavior of an absorption-based air-conditioning installation of a university building in Tarragona, Spain. The existing monitoring system of the installation has been improved by implementing additional sensors and flow meters. The data has been stored during summer 2002 and used to assess the energy balance of the air-conditioning installation and the operational regime of the absorption chiller. [Author].

A radioactive waste transportation package monitoring system for normal transport and accident emergency response conditions

International Nuclear Information System (INIS)

Brown, G.S.; Cashwell, J.W.; Apple, M.L.

1993-01-01

This paper addresses spent fuel and high level waste transportation history and prospects, discusses accident histories of radioactive material transport, discusses emergency responder needs and provides a general description of the Transportation Intelligent Monitoring System (TRANSIMS) design. The key objectives of the monitoring system are twofold: (1) to facilitate effective emergency response to accidents involving a radioactive waste transportation package, while minimizing risk to the public and emergency first-response personnel, and (2) to allow remote monitoring of transportation vehicle and payload conditions to enable research into radioactive material transportation for normal and accident conditions. (J.P.N.)

AN EVALUATION OF CONDITION MONITORING TECHNIQUES FOR LOW-VOLTAGE ELECTRIC CABLES

International Nuclear Information System (INIS)

LOFARO, R.J.; GROVE, E.; SOO, P.

2000-01-01

Aging of systems and components in nuclear power plants is a well known occurrence that must be managed to ensure the continued safe operation of these plants. Much of the degradation due to aging is controlled through periodic maintenance and/or component replacement. However, there are components that do not receive periodic maintenance or monitoring once they are installed; electric cables are such a component. To provide a means of monitoring the condition of electric cables, research is ongoing to evaluate promising condition monitoring (CM) techniques that can be used in situ to monitor cable condition and predict remaining life. While several techniques are promising, each has limitations that must be considered in its application. This paper discusses the theory behind several of the promising cable CM techniques being studied, along with their effectiveness for monitoring aging degradation in typical cable insulation materials, such as cross-linked polyethylene and ethylene propylene rubber. Successes and limitations of each technique are also presented

Genetic identification of F1 and post-F1 serrasalmid juvenile hybrids in Brazilian aquaculture.

Directory of Open Access Journals (Sweden)

Diogo Teruo Hashimoto

Full Text Available Juvenile fish trade monitoring is an important task on Brazilian fish farms. However, the identification of juvenile fish through morphological analysis is not feasible, particularly between interspecific hybrids and pure species individuals, making the monitoring of these individuals difficult. Hybrids can be erroneously identified as pure species in breeding facilities, which might reduce production on farms and negatively affect native populations due to escapes or stocking practices. In the present study, we used a multi-approach analysis (molecular and cytogenetic markers to identify juveniles of three serrasalmid species (Colossoma macropomum, Piaractus mesopotamicus and Piaractus brachypomus and their hybrids in different stocks purchased from three seed producers in Brazil. The main findings of this study were the detection of intergenus backcrossing between the hybrid ♀ patinga (P. mesopotamicus×P. brachypomus×♂ C. macropomum and the occurrence of one hybrid triploid individual. This atypical specimen might result from automixis, a mechanism that produces unreduced gametes in some organisms. Moreover, molecular identification indicated that hybrid individuals are traded as pure species or other types of interspecific hybrids, particularly post-F1 individuals. These results show that serrasalmid fish genomes exhibit high genetic heterogeneity, and multi-approach methods and regulators could improve the surveillance of the production and trade of fish species and their hybrids, thereby facilitating the sustainable development of fish farming.

Machine and lubricant condition monitoring for extended equipment lifetimes and predictive maintenance

Energy Technology Data Exchange (ETDEWEB)

Lukas, M; Anderson, D P [Spectro Incorporated, Littleton, Massachusetts (United States)

1998-12-31

Predictive maintenance has gained wide acceptance as a cost cutting strategy in modern industry. Condition monitoring by lubricant analysis is one of the basic tools of a predictive maintenance program along with vibration monitoring, performance monitoring and thermography. In today`s modern power generation, manufacturing, refinery, transportation, mining, and military operations, the cost of equipment maintenance, service, and lubricants are ever increasing. Parts, labor, equipment downtime and lubricant prices and disposal costs are a primary concern in a well run maintenance management program. Machine condition monitoring based on oil analysis has become a prerequisite in most maintenance programs. Few operations can afford not to implement a program if they wish to remain competitive, and in some cases, profitable. This presentation describes a comprehensive Machine Condition Monitoring Program based on oil analysis. Actual operational condition monitoring programs will be used to review basic components and analytical requirements. Case histories will be cited as examples of cost savings, reduced equipment downtime and increased efficiencies of maintenance programs through a well managed oil analysis program. (orig.)

Machine and lubricant condition monitoring for extended equipment lifetimes and predictive maintenance

Energy Technology Data Exchange (ETDEWEB)

Lukas, M.; Anderson, D.P. [Spectro Incorporated, Littleton, Massachusetts (United States)

1997-12-31

Predictive maintenance has gained wide acceptance as a cost cutting strategy in modern industry. Condition monitoring by lubricant analysis is one of the basic tools of a predictive maintenance program along with vibration monitoring, performance monitoring and thermography. In today`s modern power generation, manufacturing, refinery, transportation, mining, and military operations, the cost of equipment maintenance, service, and lubricants are ever increasing. Parts, labor, equipment downtime and lubricant prices and disposal costs are a primary concern in a well run maintenance management program. Machine condition monitoring based on oil analysis has become a prerequisite in most maintenance programs. Few operations can afford not to implement a program if they wish to remain competitive, and in some cases, profitable. This presentation describes a comprehensive Machine Condition Monitoring Program based on oil analysis. Actual operational condition monitoring programs will be used to review basic components and analytical requirements. Case histories will be cited as examples of cost savings, reduced equipment downtime and increased efficiencies of maintenance programs through a well managed oil analysis program. (orig.)

Optimization and effects of different culture conditions on growth of Halomicronema hongdechloris – a filamentous cyanobacterium containing chlorophyll f

Directory of Open Access Journals (Sweden)

Yaqiong eLi

2014-02-01

Full Text Available A chlorophyll f containing cyanobacterium, Halomicronema hongdechloris (H. hongdechloris was isolated from a stromatolite cyanobacterial community. However, the extremely slower growth rate of H. hongdechloris culture became a critical factor, hindering the research on this newly isolated cyanobacterium and the investigation of chlorophyll f-photosynthesis. Therefore, optimizing H. hongdechloris culture conditions has become an essential requirement for future research. This work investigated the effects of various culture conditions, essential nutrients and light environments to determine the optimal growth conditions for H. hongdechloris and the biosynthetic rate of chlorophyll f. Based on the total chlorophyll concentration, an optimal growth rate of 0.22 ± 0.02 day-1 (doubling time: 3.1 ± 0.3 days was observed when cells were grown under continuous illumination with far-red light with an intensity of 20 µE at 32°C in modified K+ES seawater (pH 8.0 with additional supplements of 11.75 mM NaNO3 and 0.15 mM K2HPO4. High performance liquid chromatography on H. hongdechloris pigments confirmed that chlorophyll a is the major chlorophyll and chlorophyll f constitutes approximately 10% of the total chlorophyll from cells grown under far-red light. Fluorescence confocal image analysis demonstrated changes of photosynthetic membranes and the distribution of photopigments in response to different light conditions. The total photosynthetic oxygen evolution yield per cell showed no changes under different light conditions, which confirms the involvement of chlorophyll f in oxygenic photosynthesis. The implications of the presence of chlorophyll f in H. hongdechloris and its relationship to light environment are discussed.

Condition monitoring of rotormachinery in nuclear power plants

International Nuclear Information System (INIS)

Suedmersen, U.; Runkel, J.; Vortriede, A.; Reimche, W.; Stegemann, D.

1996-01-01

Due to safety and economical reasons diagnostic and monitoring systems are of growing interest in nuclear power plants and other complex industrial productions. Key components of NPP's are rotating machineries of the primary and secondary loops like PWR main coolant pumps, BWR recirculation pumps, turbines, fresh water pumps and feed water pumps. Diagnostic systems are requested which detect, diagnose and localize faulty operation conditions at an early stage in order to prevent severe failures and to enable predictive and condition oriented maintenance. The knowledge of characteristical machine signatures and their time dependent behaviour are the basis of efficient condition monitoring of rotating machines. The performance of reference measurements are of importance for fault detection during operation by trend settings. The comparison with thresholds given by norms and standards is only a small section of available possibilities. Therefore, for each machinery own thresholds should be determined using statistical time values, spectra comparison, cepstrum analysis and correlation analysis for source localization corresponding to certain machine operation conditions. (author). 14 refs, 15 figs

Condition monitoring of rotormachinery in nuclear power plants

Energy Technology Data Exchange (ETDEWEB)

Suedmersen, U; Runkel, J; Vortriede, A; Reimche, W; Stegemann, D [University of Hannover, Hannover (Germany). Inst. of Nuclear Engineering and Nondestructive Testing

1997-12-31

Due to safety and economical reasons diagnostic and monitoring systems are of growing interest in nuclear power plants and other complex industrial productions. Key components of NPP`s are rotating machineries of the primary and secondary loops like PWR main coolant pumps, BWR recirculation pumps, turbines, fresh water pumps and feed water pumps. Diagnostic systems are requested which detect, diagnose and localize faulty operation conditions at an early stage in order to prevent severe failures and to enable predictive and condition oriented maintenance. The knowledge of characteristical machine signatures and their time dependent behaviour are the basis of efficient condition monitoring of rotating machines. The performance of reference measurements are of importance for fault detection during operation by trend settings. The comparison with thresholds given by norms and standards is only a small section of available possibilities. Therefore, for each machinery own thresholds should be determined using statistical time values, spectra comparison, cepstrum analysis and correlation analysis for source localization corresponding to certain machine operation conditions. (author). 14 refs, 15 figs.

Ultraviolet radiation monitoring in makkah city, Saudi Arabia, using thermoluminescence material CaF2:Tm

International Nuclear Information System (INIS)

Al-Ghorabie, F.H.; Natto, S.S.; AL-Lehyani, S.A.

2005-01-01

The aim of the present study is to explore the possibility of using Ca F2:Tm thermoluminescence material for measuring and monitoring of solar UV R in Makkah City, Saudi Arabia. Several laboratory experiments, prior to the field measurements, were performed included study of the effects of ultraviolet wavelengths on the response of the phosphor, study of the effect of increasing ultraviolet radiation dose on the intensity of thermoluminescence and study the effect of time factor on the thermoluminescence fading of Ca F 2 :Tm. The phosphor was then exposed directly for one hour to sunlight radiation on a daily basis for 90 days in an open field inside Umm Al-Qura university campus. The field measurements were performed during the months of June, July and August 2003 at 1:00 p.m. The laboratory and field results of this study showed that Ca F 2 :Tm can be used as a suitable dosimeter for solar UV R

Første fælles nordiske monitorering af kost, fysisk aktivitet og overvægt

DEFF Research Database (Denmark)

Fagt, Sisse; Rasmussen, Lone Banke; Trolle, Ellen

2012-01-01

Som en vigtig del af den nordiske handlingsplan for bedre sundhed og livskvalitet gennem kost og fysisk aktivitet har Nordisk Ministerråd besluttet at udvikle og gennemføre en fælles nordisk undersøgelse af kost, fysisk aktivitet og overvægt. Den første monitorering gennemførtes i Norge, Sverige,...

Desgin of On-line Monitoring Device for MOA (Metal Oxide Arrestor Based on FPGA and C8051F

Directory of Open Access Journals (Sweden)

Xiaotong YAO

2014-10-01

Full Text Available Monitoring of metal oxide surge arresters (MOA due to aging, moisture and other components cause increased resistive current. Through a lot of practices, it has been proved that in the early days, MOA insulation damage and current increase is not obvious. The accurate working conditions of the MOA are also not obvious but it can reflect the aging or moisture of MOA. When the resistive current of the fundamental component increases, there is no increment in the harmonic components that is the general performance of a serious or moisture contamination. In the same way when the resistive current of harmonic components increases, the fundamental component is not increased and it is the general performance of aging. Therefore, this paper designed an experiment-based FPGA and C8051F-line monitoring device. This device uses resistive current as a detection target. The main monitoring parameters are the fundamental and peak value of resistive current, third harmonic content of the leakage current, phase angle difference and power consumption. Through laboratory tests, the device can be used with a network arrester line monitoring, maintenance, reduce the economic losses caused by power outages and improve the distribution network reliability.

Luminosity Measurements with the ATLAS Detector

CERN Document Server

Maettig, Stefan; Pauly, T

For almost all measurements performed at the Large Hadron Collider (LHC) one crucial ingredient is the precise knowledge about the integrated luminosity. The determination and precision on the integrated luminosity has direct implications on any cross-section measurement, and its instantaneous measurement gives important feedback on the conditions at the experimental insertions and on the accelerator performance. ATLAS is one of the main experiments at the LHC. In order to provide an accurate and reliable luminosity determination, ATLAS uses a variety of different sub-detectors and algorithms that measure the luminosity simultaneously. One of these sub-detectors are the Beam Condition Monitors (BCM) that were designed to protect the ATLAS detector from potentially dangerous beam losses. Due to its fast readout and very clean signals this diamond detector is providing in addition since May 2011 the official ATLAS luminosity. This thesis describes the calibration and performance of the BCM as a luminosity detec...

Microwave-assisted one-pot radiosynthesis of 2′-deoxy-2′-[18F]fluoro-5-methyl-1-β-D-arabinofuranosyluracil ([18F]-FMAU)

International Nuclear Information System (INIS)

Chen, Kai; Li Zibo; Conti, Peter S.

2012-01-01

Objectives: [ 18 F]-FMAU is a PET tracer being evaluated for imaging cell proliferation. Current multi-step procedures of [ 18 F]-FMAU synthesis are time-consuming, resulting in low radiochemical yield and inconvenient applications for the clinic. We have previously reported the use of Friedel-Crafts catalysts for an improved synthesis of [ 18 F]-FMAU. In this study, we investigated the efficiency of microwave-assisted radiosynthesis of [ 18 F]-FMAU in comparison with conventional thermal conditions. Methods: A simplified one-pot synthesis of [ 18 F]-FMAU was developed under microwave conditions. Various reaction times, temperatures, and microwave powers were systematically explored to optimize the coupling reaction of 2-deoxy-2-[ 18 F]fluoro-1,3,5-tri-O-benzoyl-D-arabinofuranose ([ 18 F]-sugar) and bis-2,4-(trimethylsilyloxy)-5-methyluracil (silylated uracil) in the presence of a Friedel-Crafts catalyst, trimethylsilyl trifluoromethanesulfonate (TMSOTf). Results: Microwave significantly enhanced the coupling efficiency of [ 18 F]-sugar and silylated uracil by reducing the reaction time to 10 min (6-fold reduction as compared to conventional heating) at 95 °C. Base hydrolysis followed by high-performance liquid chromatography purification produced the desired [ 18 F]-FMAU. The overall radiochemical yield was 20 ± 4% (decay corrected, n = 3). Radiochemical purity was > 99% and specific activity was > 400 mCi/μmol. The α/β anomer ratio was 1:2. The radiosynthesis time was about 90 min from the end of bombardment. Conclusions: A reliable microwave-assisted approach has been developed for routine synthesis of [ 18 F]-FMAU. The new approach affords a simplified process with shorter synthesis time and higher radiochemical yield as compared to conventional heating. A fully automated microwave-assisted synthesis of [ 18 F]-FMAU can be readily achieved under new reaction conditions.

In vivo and in vitro characterization of [{sup 18}F]-FE-(+)-DTBZ as a tracer for beta-cell mass

Energy Technology Data Exchange (ETDEWEB)

Eriksson, Olof [Division of Radiology, Department of Oncology, Radiology and Clinical Immunology, University Hospital, 751 87 Uppsala (Sweden)], E-mail: olof.eriksson@radiol.uu.se; Jahan, Mahabuba [Department of Clinical Neuroscience, Karolinska Institute, Section of Psychiatry, Karolinska Hospital, 171 76, Stockholm (Sweden); Johnstroem, Peter [Department of Clinical Neuroscience, Karolinska Institute, Section of Psychiatry, Karolinska Hospital, 171 76, Stockholm (Sweden); CNS and Pain Control, AstraZeneca R and D, 151 36, Soedertaelje (Sweden); Korsgren, Olle [Department of Oncology, Radiology and Clinical Immunology, Division of Clinical Immunology, University Hospital, 751 87 Uppsala (Sweden); Sundin, Anders [Division of Radiology, Department of Oncology, Radiology and Clinical Immunology, University Hospital, 751 87 Uppsala (Sweden); Department of Radiology, Karolinska University Hospital, 171 76, Stockholm (Sweden); Halldin, Christer [Department of Clinical Neuroscience, Karolinska Institute, Section of Psychiatry, Karolinska Hospital, 171 76, Stockholm (Sweden); Johansson, Lars [Division of Radiology, Department of Oncology, Radiology and Clinical Immunology, University Hospital, 751 87 Uppsala (Sweden); AstraZeneca R and D, 431 50, Moelndal (Sweden)

2010-04-15

Introduction: The positron emission tomography (PET) tracer 9-[{sup 18}F]fluoroethyl-(+)-dihydrotetrabenazine ([{sup 18}F]-FE-(+)-DTBZ) is a potential candidate for quantifying beta-cell mass in vivo. The purpose was to investigate in vitro and in vivo utility of this tracer for the assessment of beta-cell mass. Methods: Three pigs were intravenously administered [{sup 18}F]-FE-(+)-DTBZ and examined by PET/computed tomography. Binding parameters were estimated by kinetic modeling. In vitro k{sub D} and B{sub max} were determined by saturation binding studies of endocrine and exocrine human tissue homogenates. In vitro pancreatic uptake was determined by tissue autoradiography with pancreases from patients with types 1 (T1DM) and 2 diabetes mellitus (T2DM) and healthy controls. Results: [{sup 18}F]-FE-(+)-DTBZ had a k{sub D} of 3.5{+-}1.0 nM, a B{sub max} of 382{+-}108 fmol/mg protein and a specificity of 89{+-}1.8% in islet homogenates. The total exocrine uptake was lower and 65% was nondisplaceable. No uptake difference was observed in pancreatic tissue slices from patients with T1DM, T2DM or healthy controls. The in vivo porcine pancreatic uptake reached a peak of standardized uptake value (SUV) of 2.8 with a low distribution volume ratio in all animals. Moderate to high tracer uptake was identified in the bile system and in bone. Conclusions: [{sup 18}F]-FE-(+)-DTBZ binds to vesicular monoamine transporter 2 (VMAT2) with high specificity in pure islet tissue in vitro. However, there is high nondisplaceable binding to exocrine tissue. In addition, in vivo tracer metabolism and dehalogenation result in severe underestimation of porcine pancreatic VMAT2 expression and BCM. The results do not support [{sup 18}F]-FE-(+)-DTBZ as a suitable tracer for in vivo beta-cell imaging.

USING CONDITION MONITORING TO PREDICT REMAINING LIFE OF ELECTRIC CABLES

International Nuclear Information System (INIS)

LOFARO, R.; SOO, P.; VILLARAN, M.; GROVE, E.

2001-01-01

Electric cables are passive components used extensively throughout nuclear power stations to perform numerous safety and non-safety functions. It is known that the polymers commonly used to insulate the conductors on these cables can degrade with time; the rate of degradation being dependent on the severity of the conditions in which the cables operate. Cables do not receive routine maintenance and, since it can be very costly, they are not replaced on a regular basis. Therefore, to ensure their continued functional performance, it would be beneficial if condition monitoring techniques could be used to estimate the remaining useful life of these components. A great deal of research has been performed on various condition monitoring techniques for use on electric cables. In a research program sponsored by the U.S. Nuclear Regulatory Commission, several promising techniques were evaluated and found to provide trendable information on the condition of low-voltage electric cables. These techniques may be useful for predicting remaining life if well defined limiting values for the aging properties being measured can be determined. However, each technique has advantages and limitations that must be addressed in order to use it effectively, and the necessary limiting values are not always easy to obtain. This paper discusses how condition monitoring measurements can be used to predict the remaining useful life of electric cables. The attributes of an appropriate condition monitoring technique are presented, and the process to be used in estimating the remaining useful life of a cable is discussed along with the difficulties that must be addressed

The Aryl Hydrocarbon Receptor Binds to E2F1 and Inhibits E2F1-induced Apoptosis

Science.gov (United States)

Marlowe, Jennifer L.; Fan, Yunxia; Chang, Xiaoqing; Peng, Li; Knudsen, Erik S.; Xia, Ying

2008-01-01

Cellular stress by DNA damage induces checkpoint kinase-2 (CHK2)-mediated phosphorylation and stabilization of the E2F1 transcription factor, leading to induction of apoptosis by activation of a subset of proapoptotic E2F1 target genes, including Apaf1 and p73. This report characterizes an interaction between the aryl hydrocarbon (Ah) receptor (AHR), a ligand-activated transcription factor, and E2F1 that results in the attenuation of E2F1-mediated apoptosis. In Ahr−/− fibroblasts stably transfected with a doxycycline-regulated AHR expression vector, inhibition of AHR expression causes a significant elevation of oxidative stress, γH2A.X histone phosphorylation, and E2F1-dependent apoptosis, which can be blocked by small interfering RNA-mediated knockdown of E2F1 expression. In contrast, ligand-dependent AHR activation protects these cells from etoposide-induced cell death. In cells expressing both proteins, AHR and E2F1 interact independently of the retinoblastoma protein (RB), because AHR and E2F1 coimmunoprecipitate from extracts of RB-negative cells. Additionally, chromatin immunoprecipitation assays indicate that AHR and E2F1 bind to the Apaf1 promoter at a region containing a consensus E2F1 binding site but no AHR binding sites. AHR activation represses Apaf1 and TAp73 mRNA induction by a constitutively active CHK2 expression vector. Furthermore, AHR overexpression blocks the transcriptional induction of Apaf1 and p73 and the accumulation of sub-G0/G1 cells resulting from ectopic overexpression of E2F1. These results point to a proproliferative, antiapoptotic function of the Ah receptor that likely plays a role in tumor progression. PMID:18524851

Evaluation of radiation protection in some nuclear medicine department

International Nuclear Information System (INIS)

Abdelrahim, Yassir Mohammed

2015-12-01

This study was carryout to evaluate the radiation protection in nuclear medicine department in Sudan, accordance with the standards international recommendation and code of practice for radiation protection in nuclear medicine, the evaluation was done for three nuclear medicine departments, included direct measurement of dose rate and the contamination level in some areas, were radiation sources, radiation workers and public are involved. The data was collected and analyzed from the results for three nuclear medicine departments that the average reading of ambient dose rate in : outside the door of imaging room (SPECT) 0.18μSv/h in hospital (1)& and 0.19μSv/h in hospital(2) and 0.19μSv/h hospital(3), inside control of imaging room (SPECT) 27.8μSv/h in hospital(1)& 0.14μSv/h in hospital(2)& 14μSv/h in hospital(3), inside the injection room 28.81μSv/h in hospital(1), 0.36μSv/h in hpspital(2), 0.06μSv/h in hospital(3) outside the door of lap, 0.65μSv/h in hospital(1), 0.13μSv/h in hospital(2) & 0.12μSv/h in hospital(3), inside the hot lap, 9.68μSv/h in hospital(1) & 0.30μSv/h in hospital(2) & 0.85 μSv/h in hospital(3), in outsidee the door of waiting room of injected patient 1.41μSv/h in hospital(1)& 0.16μSv/h in hospital(2) & 1.08μSv/h in hospital(3). Avaerge reading of contamination in: Floor of hot lap 44.50 B/cm"2 hospital(1) & 4.42B/cm"2in hospital(2) & 6.22 B/cm"2 in hospital (3) . on the bench tap 186.30 B/cm"2 hospital(1), 19.91 B/cm"2 in hospital(2) & 8.77B/cm"2 in hospital(3) floor of injection room 12.60 B/cm"2 in hospital(1) & 11.70 B/cm"2 in hospital(2) & 13.73 B/cm"2 hospital(3) & table of injection room 13.00 B/cm"2 in hospital(1)& 11.70 B/cm"2in hospital(2)& 13.73 B/cm"2 in hospital & tble of injection room 13.00 B/cm"2 in hospital(1) & 20.40 B/cm"2 in hospital(2) & 23.23 B/cm"2 B/cm"2 in hospital(3) on the shield of working surface 144.30 B/cm in hospital(1)& 47.00 B/cm"2 in hospital(2) & 52.33 B/cm"2 in hospital(3) , and makes check

Bridge condition assessment based on long-term strain monitoring

Science.gov (United States)

Sun, LiMin; Sun, Shouwang

2011-04-01

In consideration of the important role that bridges play as transportation infrastructures, their safety, durability and serviceability have always been deeply concerned. Structural Health Monitoring Systems (SHMS) have been installed to many long-span bridges to provide bridge engineers with the information needed in making rational decisions for maintenance. However, SHMS also confronted bridge engineers with the challenge of efficient use of monitoring data. Thus, methodologies which are robust to random disturbance and sensitive to damage become a subject on which many researches in structural condition assessment concentrate. In this study, an innovative probabilistic approach for condition assessment of bridge structures was proposed on the basis of long-term strain monitoring on steel girder of a cable-stayed bridge. First, the methodology of damage detection in the vicinity of monitoring point using strain-based indices was investigated. Then, the composition of strain response of bridge under operational loads was analyzed. Thirdly, the influence of temperature and wind on strains was eliminated and thus strain fluctuation under vehicle loads is obtained. Finally, damage evolution assessment was carried out based on the statistical characteristics of rain-flow cycles derived from the strain fluctuation under vehicle loads. The research conducted indicates that the methodology proposed is qualified for structural condition assessment so far as the following respects are concerned: (a) capability of revealing structural deterioration; (b) immunity to the influence of environmental variation; (c) adaptability to the random characteristic exhibited by long-term monitoring data. Further examination of the applicability of the proposed methodology in aging bridge may provide a more convincing validation.

Model Based Optimal Sensor Network Design for Condition Monitoring in an IGCC Plant

Energy Technology Data Exchange (ETDEWEB)

Kumar, Rajeeva; Kumar, Aditya; Dai, Dan; Seenumani, Gayathri; Down, John; Lopez, Rodrigo

2012-12-31

these two formulations were developed and validated. For a given OSP problem the computation efficiency largely depends on the “size” of the problem. Initially a simplified 1-D gasifier model assuming axial and azimuthal symmetry was used to test out various OSP algorithms. Finally these algorithms were used to design the optimal sensor network for condition monitoring of IGCC gasifier refractory wear and RSC fouling. The sensors type and locations obtained as solution to the OSP problem were validated using model based sensing approach. The OSP algorithm has been developed in a modular form and has been packaged as a software tool for OSP design where a designer can explore various OSP design algorithm is a user friendly way. The OSP software tool is implemented in Matlab/Simulink© in-house. The tool also uses few optimization routines that are freely available on World Wide Web. In addition a modular Extended Kalman Filter (EKF) block has also been developed in Matlab/Simulink© which can be utilized for model based sensing of important process variables that are not directly measured through combining the online sensors with model based estimation once the hardware sensor and their locations has been finalized. The OSP algorithm details and the results of applying these algorithms to obtain optimal sensor location for condition monitoring of gasifier refractory wear and RSC fouling profile are summarized in this final report.

Nonlinear Cointegration Approach for Condition Monitoring of Wind Turbines

Directory of Open Access Journals (Sweden)

Konrad Zolna

2015-01-01

Full Text Available Monitoring of trends and removal of undesired trends from operational/process parameters in wind turbines is important for their condition monitoring. This paper presents the homoscedastic nonlinear cointegration for the solution to this problem. The cointegration approach used leads to stable variances in cointegration residuals. The adapted Breusch-Pagan test procedure is developed to test for the presence of heteroscedasticity in cointegration residuals obtained from the nonlinear cointegration analysis. Examples using three different time series data sets—that is, one with a nonlinear quadratic deterministic trend, another with a nonlinear exponential deterministic trend, and experimental data from a wind turbine drivetrain—are used to illustrate the method and demonstrate possible practical applications. The results show that the proposed approach can be used for effective removal of nonlinear trends form various types of data, allowing for possible condition monitoring applications.

Condition Monitoring Of Operating Pipelines With Operational Modal Analysis Application

Directory of Open Access Journals (Sweden)

Mironov Aleksey

2015-12-01

Full Text Available In the petroleum, natural gas and petrochemical industries, great attention is being paid to safety, reliability and maintainability of equipment. There are a number of technologies to monitor, control, and maintain gas, oil, water, and sewer pipelines. The paper focuses on operational modal analysis (OMA application for condition monitoring of operating pipelines. Special focus is on the topicality of OMA for definition of the dynamic features of the pipeline (frequencies and mode shapes in operation. The research was conducted using two operating laboratory models imitated a part of the operating pipeline. The results of finite-element modeling, identification of pipe natural modes and its modification under the influence of virtual failure are discussed. The work considers the results of experimental research of dynamic behavior of the operating pipe models using one of OMA techniques and comparing dynamic properties with the modeled data. The study results demonstrate sensitivity of modal shape parameters to modification of operating pipeline technical state. Two strategies of pipeline repair – with continuously condition-based monitoring with proposed technology and without such monitoring, was discussed. Markov chain reliability models for each strategy were analyzed and reliability improvement factor for proposed technology of monitoring in compare with traditional one was evaluated. It is resumed about ability of operating pipeline condition monitoring by measuring dynamic deformations of the operating pipe and OMA techniques application for dynamic properties extraction.

Characterization of field-evolved resistance to Bacillus thuringiensis-derived Cry1F δ-endotoxin in Spodoptera frugiperda populations from Argentina.

Science.gov (United States)

Chandrasena, Desmi I; Signorini, Ana M; Abratti, Gustavo; Storer, Nicholas P; Olaciregui, Magdalena L; Alves, Analiza P; Pilcher, Clinton D

2018-03-01

Transgenic maize (Zea mays L.) event TC1507 (Herculex ® I insect protection), expressing Cry1F δ-endotoxin derived from Bacillus thuringiensis var. aizawai, was commercialized in 2003 in the Americas. Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) susceptibility to Cry1F was monitored annually across several regions in Argentina using diagnostic concentration bioassays. Reduced performance of TC1507 maize against S. frugiperda was reported in 2013. A resistant population was established in the laboratory and the dominance of Cry1F resistance was characterized. During 2012-2015, high-survivorship of several populations was observed in the resistance monitoring program. Reciprocal crosses of a Cry1F-resistant population with a Cry1F-susceptible population were evaluated to calculate effective dominance (D ML ) based on mortality levels observed at 100 µg/ml Cry1F. Two additional dominance levels (D LC and D EC ) were calculated using lethal (LC 50 ) or effective concentration (EC 50 ) derived from concentration-response bioassays. Estimates indicated that Cry1F resistance in S. frugiperda in Argentina was either highly recessive (D ML = 0.005) or incompletely recessive (D LC frugiperda Cry1F field-evolved resistance in Argentina. The resistance to Cry1F in S. frugiperda populations collected in Argentina, is autosomal and incompletely recessive similar to the resistance reported in Brazil. © 2017 The Authors. Pest Management Science published by John Wiley © Sons Ltd on behalf of Society of Chemical Industry. © 2017 The Authors. Pest Management Science published by John Wiley © Sons Ltd on behalf of Society of Chemical Industry.

Acoustic monitoring systems tests at Indian Point Unit 1. Final report

International Nuclear Information System (INIS)

Smith, J.R.; Rao, G.V.; Craig, J.

1979-12-01

This report describes the results of a program to test acoustic monitoring systems on Indian Point Unit No. 1 under actual plant operating conditions, less the reactor core. The two types of systems evaluated were the monitoring of acoustic emissions generated by growing flaws and the monitoring of acoustic signals from leaks

Advanced condition monitoring program for turbine system

International Nuclear Information System (INIS)

Ono, Shigetoshi

2015-01-01

It is important for utilities to achieve a stable operation in nuclear power plants. To achieve it, plant anomalies that affect a stable operation must be found out and eliminated. Therefore, the advanced condition monitoring program was developed. In this program, a sophisticated heat balance model based on the actual plant data is adopted to identify plant anomalies at an incipient stage and the symptoms of plant anomalies are found by heat balance changes from the model calculation. The model calculation results have shown precise prediction for actual plant parameters. Moreover, this program has the diagnostic engine that helps operators derive the cause of plant anomalies. By using this monitoring program, the component reliability in the turbine system can be periodically monitored and assessed, and as a result the stable operation of nuclear power plants can be achieved. (author)

Tolkku - a toolbox for decision support from condition monitoring data

International Nuclear Information System (INIS)

Saarela, Olli; Lehtonen, Mikko; Halme, Jari; Aikala, Antti; Raivio, Kimmo

2012-01-01

This paper describes a software toolbox (a software library) designed for condition monitoring and diagnosis of machines. This toolbox implements both new methods and prior art and is aimed for practical down-to-earth data analysis work. The target is to improve knowledge of the operation and behaviour of machines and processes throughout their entire life-cycles. The toolbox supports different phases of condition based maintenance with tools that extract essential information and automate data processing. The paper discusses principles that have guided toolbox design and the implemented toolbox structure. Case examples are used to illustrate how condition monitoring applications can be built using the toolbox. In the first case study the toolbox is applied to fault detection of industrial centrifuges based on measured electrical current. The second case study outlines an application for centralized monitoring of a fleet of machines that supports organizational learning.

26 CFR 1.642(f)-1 - Amortization deductions.

Science.gov (United States)

2010-04-01

....642(f)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Estates, Trusts, and Beneficiaries § 1.642(f)-1 Amortization deductions. An estate... respect to qualified railroad rolling stock as defined in section 184(d), with respect to certified coal...

Wire system aging assessment and condition monitoring (WASCO)

International Nuclear Information System (INIS)

Fantoni, P.F.

2007-04-01

Nuclear facilities rely on electrical wire systems to perform a variety of functions for successful operation. Many of these functions directly support the safe operation of the facility; therefore, the continued reliability of wire systems, even as they age, is critical. Condition Monitoring (CM) of installed wire systems is an important part of any aging program, both during the first 40 years of the qualified life and even more in anticipation of the license renewal for a nuclear power plant. This report contains some test results of a method for wire system condition monitoring, developed at the Halden Reactor Project, called LIRA (LIne Resonance Analysis), which can be used on-line to detect any local or global changes in the cable electrical parameters as a consequence of insulation faults or degradation. (au)

Cyclisation versus 1,1-Carboboration: Reactions of B(C6F5)3 with Propargyl Amides.

Science.gov (United States)

Melen, Rebecca L; Hansmann, Max M; Lough, Alan J; Hashmi, A Stephen K; Stephan, Douglas W

2013-09-02

A series of propargyl amides were prepared and their reactions with the Lewis acidic compound B(C6F5)3 were investigated. These reactions were shown to afford novel heterocycles under mild conditions. The reaction of a variety of N-substituted propargyl amides with B(C6F5)3 led to an intramolecular oxo-boration cyclisation reaction, which afforded the 5-alkylidene-4,5-dihydrooxazolium borate species. Secondary propargyl amides gave oxazoles in B(C6F5)3 mediated (catalytic) cyclisation reactions. In the special case of disubstitution adjacent to the nitrogen atom, 1,1-carboboration is favoured as a result of the increased steric hindrance (1,3-allylic strain) in the 5-alkylidene-4,5-dihydrooxazolium borate species. Copyright © 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim.

Behaviour of the intermediate region of the ionosphere at F1 heights

International Nuclear Information System (INIS)

Radicella, S.M.; Mosert Gonzalez, M. de; Scotto, C.; Zolesi, B.; Jadur, C.A.

1997-01-01

The characteristics and occurrence of the F1 ledge in the electron density profile are reviewed and discussed in terms of its relevance for the empirical modelling of the ionosphere. An updated and selected data base is used to confirm the validity the DuCharme et al. formula taking into account alternative solutions for the particular occurrence restrictions imposed by the formula and the IRI-90. The information considered includes also L conditions that indicates the presence of a less defined F1 cusp in the ionogram. A probability of occurrence of the F1 layer is introduced making use of the hourly ionogram scaling information given in monthly bulletins of ionospheric data. The possible prediction of the electron density at fixed heights in the F1 region is discussed and a formulation for such prediction is proposed as a preliminary step. (author). 10 refs, 7 figs, 2 tabs

Strongly nonlinear nonhomogeneous elliptic unilateral problems with L^1 data and no sign conditions

Directory of Open Access Journals (Sweden)

Elhoussine Azroul

2012-05-01

Full Text Available In this article, we prove the existence of solutions to unilateral problems involving nonlinear operators of the form: $$ Au+H(x,u,abla u=f $$ where $A$ is a Leray Lions operator from $W_0^{1,p(x}(Omega$ into its dual $W^{-1,p'(x}(Omega$ and $H(x,s,xi$ is the nonlinear term satisfying some growth condition but no sign condition. The right hand side $f$ belong to $L^1(Omega$.

Nesterenkonia sp. strain F, a halophilic bacterium producing acetone, butanol, and ethanol under aerobic conditions.

Science.gov (United States)

Amiri, Hamid; Azarbaijani, Reza; Parsa Yeganeh, Laleh; Shahzadeh Fazeli, Abolhassan; Tabatabaei, Meisam; Salekdeh, Ghasem Hosseini; Karimi, Keikhosro

2016-01-04

The moderately halophilic bacterium Nesterenkonia sp. strain F, which was isolated from Aran-Bidgol Lake (Iran), has the ability to produce acetone, butanol, and ethanol (ABE) as well as acetic and butyric acids under aerobic and anaerobic conditions. This result is the first report of ABE production with a wild microorganism from a family other than Clostridia and also the first halophilic species shown to produce butanol under aerobic cultivation. The cultivation of Nesterenkonia sp. strain F under anaerobic conditions with 50 g/l of glucose for 72 h resulted in the production of 105 mg/l of butanol, 122 mg/l of acetone, 0.2 g/l of acetic acid, and 2.5 g/l of butyric acid. Furthermore, the strain was cultivated on media with different glucose concentrations (20, 50, and 80 g/l) under aerobic and anaerobic conditions. Through fermentation with a 50 g/l initial glucose concentration under aerobic conditions, 66 mg/l of butanol, 125 mg/l of acetone, 291 mg/l of ethanol, 5.9 g/l of acetic acid, and 1.2 g/l of butyric acid were produced. The enzymes pertaining to the fermentation pathway in the strain were compared with the enzymes of Clostridium spp., and the metabolic pathway of fermentation used by Nesterenkonia sp. strain F was investigated.

Structure and function of the latent F0-F1-ATPase complex of Micrococcus lysodeikticus

International Nuclear Information System (INIS)

Chung, Y.S.

1988-01-01

The latent F 0 F 1 -ATPase from Micrococcus luteus (lysodeikticus) has been purified to homogeneity, and nine distinct subunit bands were observed on SDS-PAGE. Five of nine bands corresponded to the F 1 subunits and the other four bands are likely to be subunits a, a', b, and c of the F 0 segment of the complex. The subunit designated as a' probably arises from proteolytic cleavage of the 25,5000 Mr subunit a. The F 0 F 1 -ATPase complex has a molecular weight of approximately 1,060,000, as determined by Fast Protein Liquid Chromatography (FPLC). It is assumed that the F 0 F 1 -ATPase peak obtained by FPLC was a dimer and that molecular weight of the F 0 F 1 -ATPase monomer was accordingly 530,000. The stoichiometry of the subunits was determined with 14 C-labeled F 0 F 1 -ATPase prepared from cells grown on medium containing 14 C-amino acids. Antibodies to the native and SDS-denatured F 1 and F 0 F 1 -ATPase as well as to individual SDS-dissociated subunits have been generated for immunochemical analysis. The arrangement of the subunits in F 1 and F 0 F 1 -ATPase have been investigated using bifunctional chemical cross-linking agents

Radiological environmental monitoring with LiF-700-H dosemeters

International Nuclear Information System (INIS)

Scarnichia, E.; Levanon, I.; Andres, P.; Miani, C.; Ramirez, S.

2011-10-01

Since 2008 a radiological environmental monitoring with LiF-700-H has been carried out as a result of increasing the Ra-6 research reactor core power. The information obtained is used to evaluate and to quantify analytically the air kerma rate, the fading and the associated uncertainty by developing software tools (deconvolution and uncertainty algorithms). LiF-700-H dosemeters were chosen because of their high sensitivity to low air kerma rates. They show a very good stability and a negligible fading for two-month working periods. The air kerma rate detection limit (based on the 3σ criterion) during these working periods is about 0.4 n Gy/h. Air kerma rates of about 70 n Gy/h are measured with this detection limit. Following the Nist guidelines, an algorithm was developed in order to find the associated uncertainty. It considers several aspects, such as the source activity decay, distance source-dosemeter during the calibration procedure, irradiation time, calibration factor, dosemeter readout, dosemeter sensitivity, TLD reader stability and fading. The associated uncertainty is found to be about 25% for a 95% confidence interval (k = 2.025), which can be considered acceptable when taking into account the very low air kerma rates estimated. The LiF-700-H response to different energies and its relationship with climate changes over the calendar year are planned as future tasks. (Author)

Wind turbine condition monitoring based on SCADA data using normal behavior models

DEFF Research Database (Denmark)

Schlechtingen, Meik; Santos, Ilmar; Achiche, Sofiane

2013-01-01

This paper proposes a system for wind turbine condition monitoring using Adaptive Neuro-Fuzzy Interference Systems (ANFIS). For this purpose: (1) ANFIS normal behavior models for common Supervisory Control And Data Acquisition (SCADA) data are developed in order to detect abnormal behavior...... the applicability of ANFIS models for monitoring wind turbine SCADA signals. The computational time needed for model training is compared to Neural Network (NN) models showing the strength of ANFIS in training speed. (2) For automation of fault diagnosis Fuzzy Interference Systems (FIS) are used to analyze...

On the use of temperature for online condition monitoring of geared systems - A review

Science.gov (United States)

Touret, T.; Changenet, C.; Ville, F.; Lalmi, M.; Becquerelle, S.

2018-02-01

Gear unit condition monitoring is a key factor for mechanical system reliability management. When they are subjected to failure, gears and bearings may generate excessive vibration, debris and heat. Vibratory, acoustic or debris analyses are proven approaches to perform condition monitoring. An alternative to those methods is to use temperature as a condition indicator to detect gearbox failure. The review focuses on condition monitoring studies which use this thermal approach. According to the failure type and the measurement method, it exists a distinction whether it is contact (e.g. thermocouple) or non-contact temperature sensor (e.g. thermography). Capabilities and limitations of this approach are discussed. It is shown that the use of temperature for condition monitoring has a clear potential as an alternative to vibratory or acoustic health monitoring.

Use of the cellular model of body composition to describe changes in body water compartments after total fasting, very low calorie diet and low calorie diet in obese men.

Science.gov (United States)

Siervo, M; Faber, P; Gibney, E R; Lobley, G E; Elia, M; Stubbs, R J; Johnstone, A M

2010-05-01

The cellular model of body composition divides the body in body cell mass (BCM), extracellular solids and extracellular fluids. This model has been infrequently applied for the evaluation of weight loss (WL) programmes. (1) To assess changes in body compartments in obese men undergoing fasting, very low calorie diet (VLCD) and low calorie diet (LCD); (2) to evaluate two cellular models for the determination of changes in BCM, fat mass (FM) and body fluids. Three groups of six, obese men participated in a total fast (F) for 6 days, a VLCD (2.5 MJ per day) for 3 weeks or an LCD (5.2 MJ per day) for 6 weeks. Body composition was measured at baseline and after small ( approximately 5%) and moderate ( approximately 10%) WL. FM was measured using a four-compartment model. Total body water (TBW) and extracellular water (ECW) were, respectively, measured by deuterium and sodium bromide dilution and intracellular water (ICW) calculated by difference. Two cellular models were used to measure BCM, FM and body fluids distribution. After about 5%WL changes in TBW were F=-3.2+/-1.2 kg (Pfasting (+1.5+/-3.1 kg, n.s.), decreased during the VLCD (-2.0+/-1.5 kg, Pfasting (-4.7+/-3.9 kg, Pfasting group and it was directly associated with changes in ICW. After a 6-day period of fasting we observed more ICW losses and less fat mobilization compared with VLCD and LCD. The cellular model of body composition is suitable for the characterization of changes in body fluids distribution during WL.

Online condition monitoring to enable extended operation of nuclear power plants

International Nuclear Information System (INIS)

Meyer, Ryan Michael; Bond, Leonard John; Ramuhalli, Pradeep

2012-01-01

Safe, secure, and economic operation of nuclear power plants will remain of strategic significance. New and improved monitoring will likely have increased significance in the post-Fukushima world. Prior to Fukushima, many activities were already underway globally to facilitate operation of nuclear power plants beyond their initial licensing periods. Decisions to shut down a nuclear power plant are mostly driven by economic considerations. Online condition monitoring is a means to improve both the safety and economics of extending the operating lifetimes of nuclear power plants, enabling adoption of proactive aging management. With regard to active components (e.g., pumps, valves, motors, etc.), significant experience in other industries has been leveraged to build the science base to support adoption of online condition-based maintenance and proactive aging management in the nuclear industry. Many of the research needs are associated with enabling proactive management of aging in passive components (e.g., pipes, vessels, cables, containment structures, etc.). This paper provides an overview of online condition monitoring for the nuclear power industry with an emphasis on passive components. Following the overview, several technology/knowledge gaps are identified, which require addressing to facilitate widespread online condition monitoring of passive components. (author)

Recent trends in the condition monitoring of transformers theory, implementation and analysis

CERN Document Server

Chakravorti, Sivaji; Chatterjee, Biswendu

2013-01-01

Recent Trends in the Condition Monitoring of Transformers reflects the current interest in replacing traditional techniques used in power transformer condition monitoring with non-invasive measures such as polarization/depolarization current measurement, recovery voltage measurement, frequency domain spectroscopy and frequency response analysis. The book stresses the importance of scrutinizing the condition of transformer insulation which may fail under present day conditions of intensive use with the resulting degradation of dielectric properties causing functional failure of the transformer.

Effect of Animal Condition and Fluvoxamine on the Result of [18F]N 3 Fluoropropyl-2β carbomethoxy-3β (4-iodophenyl) Nortropane ([18F]FP-CIT) PET Study in Mice

International Nuclear Information System (INIS)

Shin, Kwang Ho; Lee Sang Ju; Oh, Seung Jun; Kim, Jae Seung; Park, Su A; Kim, Seog Young

2012-01-01

PET (positron emission tomography) is a noninvasive imaging technique, visualizing biological aspects in vivo. In animal models, the result of PET study can be affected more prominently than in humans by the animal conditions or drug pretreatment. We assessed the effects of anesthesia, body temperature, and pretreatment with selective serotonin reuptake inhibitor on the results of [ 18F ]N 3 fluoropropyl 2β carbomethoxy 3β (4-iodophenyl) nortropane ([ 18F ]FP CIT) PET in mice. [ 18F ]FP CIT PET of C57BL/6 mice was performed in three different conditions: (1) anesthesia (isoflurane) with active warming (38.deg.C) as a reference; (2) no anesthesia or warming; (3) anesthesia without warming at room temperature. Additional groups of mine pretreated with escalating doses of fluvoxamine (5, 20, 40, 80 mg/kg) were imaged in condition (1). The time activity curve and standardized uptake value of the striatum, cerebral cortex, and bone were compared among these conditions. In all conditions, radioactivities of the striatum and cortex tended to form a plateau after rapid uptake and washout, but that of bone tended to increase gradually. When anesthetized without any warming, all the mice developed hypothermia and showed reduced bone uptake compared to the reference condition. In conditions without anesthesia, striatal and cortical uptakes compared to the reference condition. In conditions without anesthesia, striatal and cortical uptakes were reduced, whereas the bone uptake showed no change. Pretreatment with fluvoxamine increased the striatal uptake and striatal specific to cortical non specific uptake ratio, whereas the bone uptake was reduced. Anesthesia, body temperature, and fluvoxamine affect the result of [ 18F ]FP CIT PET in mice by altering striatal and bone uptakes

Subunit rotation in a single FoF1-ATP synthase in a living bacterium monitored by FRET

Science.gov (United States)

Seyfert, K.; Oosaka, T.; Yaginuma, H.; Ernst, S.; Noji, H.; Iino, R.; Börsch, M.

2011-03-01

FoF1-ATP synthase is the ubiquitous membrane-bound enzyme in mitochondria, chloroplasts and bacteria which provides the 'chemical energy currency' adenosine triphosphate (ATP) for cellular processes. In Escherichia coli ATP synthesis is driven by a proton motive force (PMF) comprising a proton concentration difference ΔpH plus an electric potential ΔΨ across the lipid membrane. Single-molecule in vitro experiments have confirmed that proton-driven subunit rotation within FoF1-ATP synthase is associated with ATP synthesis. Based on intramolecular distance measurements by single-molecule fluorescence resonance energy transfer (FRET) the kinetics of subunit rotation and the step sizes of the different rotor parts have been unraveled. However, these experiments were accomplished in the presence of a PMF consisting of a maximum ΔpH ~ 4 and an unknown ΔΨ. In contrast, in living bacteria the maximum ΔpH across the plasma membrane is likely 0.75, and ΔΨ has been measured between -80 and -140 mV. Thus the problem of in vivo catalytic turnover rates, or the in vivo rotational speed in single FoF1-ATP synthases, respectively, has to be solved. In addition, the absolute number of functional enzymes in a single bacterium required to maintain the high ATP levels has to be determined. We report our progress of measuring subunit rotation in single FoF1-ATP synthases in vitro and in vivo, which was enabled by a new labeling approach for single-molecule FRET measurements.

Epitaxial growth of lithium fluoride on the (1 1 1) surface of CaF 2

Science.gov (United States)

Klumpp, St; Dabringhaus, H.

1999-08-01

Growth of lithium fluoride by molecular beam epitaxy on the (1 1 1) surface of calcium fluoride crystals was studied by TEM and LEED for crystal temperatures from 400 to 773 K and impinging lithium fluoride fluxes from 3×10 11 to 3×10 14 cm -2 s -1. Growth starts, usually, at the steps on the (1 1 1) surface of CaF 2. For larger step distances and at later growth stages also growth on the terraces between the steps is found. Preferably, longish, roof-like crystallites are formed, which can be interpreted by growth of LiF(2 0 1¯)[0 1 0] parallel to CaF 2(1 1 1)[ 1¯ 0 1]. To a lesser extent square crystallites, i.e. growth with LiF(0 0 1), and, rarely, three-folded pyramidal crystallites, i.e. growth with LiF(1 1 1) parallel to CaF 2(1 1 1), are observed. While the pyramidal crystallites show strict epitaxial orientation with LiF[ 1¯ 0 1]‖CaF 2[ 1¯ 0 1] and LiF[ 1¯ 0 1]‖CaF 2[1 2¯ 1], only about 80% of the square crystallites exhibit an epitaxial alignment, where LiF[1 0 0]‖CaF 2[ 1¯ 0 1] is preferred to LiF[1 1 0]‖CaF 2[ 1¯ 0 1]. The epitaxial relationships are discussed on the basis of theoretically calculated adsorption positions of the lithium fluoride monomer and dimer on the terrace and at the steps of the CaF 2(1 1 1) surface.

SPECTRAL OPTICAL MONITORING OF THE NARROW-LINE SEYFERT 1 GALAXY Ark 564

International Nuclear Information System (INIS)

Shapovalova, A. I.; Burenkov, A. N.; Popović, L. Č.; Kovačević, J.; Chavushyan, V. H.; Valdes, J. R.; Torrealba, J.; Carrasco, L.; Ilić, D.; Kovačević, A.; Kollatschny, W.; Bochkarev, N. G.; León-Tavares, J.; Mercado, A.; Benítez, E.; Dultzin, D.; De la Fuente, E.

2012-01-01

We present the results of a long-term (1999-2010) spectral optical monitoring campaign of the active galactic nucleus (AGN) Ark 564, which shows a strong Fe II line emission in the optical. This AGN is a narrow-line Seyfert 1 (NLS1) galaxy, a group of AGNs with specific spectral characteristics. We analyze the light curves of the permitted Hα, Hβ, optical Fe II line fluxes, and the continuum flux in order to search for a time lag between them. Additionally, in order to estimate the contribution of iron lines from different multiplets, we fit the Hβ and Fe II lines with a sum of Gaussian components. We find that during the monitoring period the spectral variation (F max /F min ) of Ark 564 is between 1.5 for Hα and 1.8 for the Fe II lines. The correlation between the Fe II and Hβ flux variations is of higher significance than that of Hα and Hβ (whose correlation is almost absent). The permitted-line profiles are Lorentzian-like and do not change shape during the monitoring period. We investigate, in detail, the optical Fe II emission and find different degrees of correlation between the Fe II emission arising from different spectral multiplets and the continuum flux. The relatively weak and different degrees of correlations between permitted lines and continuum fluxes indicate a rather complex source of ionization of the broad-line emission region.

SPECTRAL OPTICAL MONITORING OF THE NARROW-LINE SEYFERT 1 GALAXY Ark 564

Energy Technology Data Exchange (ETDEWEB)

Shapovalova, A. I.; Burenkov, A. N. [Special Astrophysical Observatory of the Russian AS, Nizhnij Arkhyz, Karachaevo-Cherkesia 369167 (Russian Federation); Popovic, L. C.; Kovacevic, J. [Astronomical Observatory, Volgina 7, 11160 Belgrade 74 (Serbia); Chavushyan, V. H.; Valdes, J. R.; Torrealba, J.; Carrasco, L. [Instituto Nacional de Astrofisica, Optica y Electronica, Apartado Postal 51-216, 72000 Puebla (Mexico); Ilic, D.; Kovacevic, A. [Isaac Newton Institute of Chile, Yugoslavia Branch, Belgrade (Serbia); Kollatschny, W. [Institut fuer Astrophysik, Georg-August-Universitaet, Goettingen (Germany); Bochkarev, N. G. [Sternberg Astronomical Institute, Moscow (Russian Federation); Leon-Tavares, J. [Aalto University Metsaehovi Radio Observatory, Metsaehovintie 114, FIN-02540 Kylmaelae (Finland); Mercado, A. [Universidad Politecnica de Baja California, Av. de la Industria 291, 21010 Mexicali, B.C. (Mexico); Benitez, E.; Dultzin, D. [Instituto de Astronomia, Universidad Nacional Autonoma de Mexico, Apartado Postal 70-264, Mexico, D.F. 04510 (Mexico); De la Fuente, E., E-mail: ashap@sao.ru [Instituto de Astronomia y Meteorologia, Dpto. de Fisica CUCEI, Universidad de Guadalajara, Av. Vallarta 2602, 44130 Guadalajara, Jalisco (Mexico)

2012-09-15

We present the results of a long-term (1999-2010) spectral optical monitoring campaign of the active galactic nucleus (AGN) Ark 564, which shows a strong Fe II line emission in the optical. This AGN is a narrow-line Seyfert 1 (NLS1) galaxy, a group of AGNs with specific spectral characteristics. We analyze the light curves of the permitted H{alpha}, H{beta}, optical Fe II line fluxes, and the continuum flux in order to search for a time lag between them. Additionally, in order to estimate the contribution of iron lines from different multiplets, we fit the H{beta} and Fe II lines with a sum of Gaussian components. We find that during the monitoring period the spectral variation (F{sub max}/F{sub min}) of Ark 564 is between 1.5 for H{alpha} and 1.8 for the Fe II lines. The correlation between the Fe II and H{beta} flux variations is of higher significance than that of H{alpha} and H{beta} (whose correlation is almost absent). The permitted-line profiles are Lorentzian-like and do not change shape during the monitoring period. We investigate, in detail, the optical Fe II emission and find different degrees of correlation between the Fe II emission arising from different spectral multiplets and the continuum flux. The relatively weak and different degrees of correlations between permitted lines and continuum fluxes indicate a rather complex source of ionization of the broad-line emission region.

Priority target conditions for algorithms for monitoring children's growth: Interdisciplinary consensus.

Directory of Open Access Journals (Sweden)

Pauline Scherdel

Full Text Available Growth monitoring of apparently healthy children aims at early detection of serious conditions through the use of both clinical expertise and algorithms that define abnormal growth. Optimization of growth monitoring requires standardization of the definition of abnormal growth, and the selection of the priority target conditions is a prerequisite of such standardization.To obtain a consensus about the priority target conditions for algorithms monitoring children's growth.We applied a formal consensus method with a modified version of the RAND/UCLA method, based on three phases (preparatory, literature review, and rating, with the participation of expert advisory groups from the relevant professional medical societies (ranging from primary care providers to hospital subspecialists as well as parent associations. We asked experts in the pilot (n = 11, reading (n = 8 and rating (n = 60 groups to complete the list of diagnostic classification of the European Society for Paediatric Endocrinology and then to select the conditions meeting the four predefined criteria of an ideal type of priority target condition.Strong agreement was obtained for the 8 conditions selected by the experts among the 133 possible: celiac disease, Crohn disease, craniopharyngioma, juvenile nephronophthisis, Turner syndrome, growth hormone deficiency with pituitary stalk interruption syndrome, infantile cystinosis, and hypothalamic-optochiasmatic astrocytoma (in decreasing order of agreement.This national consensus can be used to evaluate the algorithms currently suggested for growth monitoring. The method used for this national consensus could be re-used to obtain an international consensus.

Condition monitoring of machinery using motor current signature analysis

International Nuclear Information System (INIS)

Kryter, R.C.; Haynes, H.D.

1989-01-01

Motor current signature analysis (MCSA) is a powerful monitoring tool for motor-driven equipment that provides a nonintrusive means for detecting the presence of mechanical and electrical abnormalities in the motor and the driven equipment, including altered conditions in the process ''downstream'' of the motor-driven equipment. It was developed at the Oak Ridge National Laboratory as a means for determining the effects of aging and service wear systems, but it is applicable to a broad range of machinery. MCSA is based on the recognition that an electric motor (ac or dc) driving a mechanical load acts as an efficient and permanently available transducer by sensing mechanical load variations, large and small, long-term and rapid, and converting them into variations in the induced current generated in the motor windings. These motor current variations are carried by the electrical cables processes as desired. Motor current signatures, obtained in both time and over time to provide early indication of degradation. Successful applications of MCSA technology (patent applied for) include not only motor-operated valves but also pumps of various designs, blowers, and air conditioning systems. Examples are presented briefly, and speculation regarding the applicability of MCSA to a broader range of equipment monitoring and production line testing is also given. 1 ref., 13 figs

Artificial intelligence tools decision support systems in condition monitoring and diagnosis

CERN Document Server

Galar Pascual, Diego

2015-01-01

Artificial Intelligence Tools: Decision Support Systems in Condition Monitoring and Diagnosis discusses various white- and black-box approaches to fault diagnosis in condition monitoring (CM). This indispensable resource: Addresses nearest-neighbor-based, clustering-based, statistical, and information theory-based techniques Considers the merits of each technique as well as the issues associated with real-life application Covers classification methods, from neural networks to Bayesian and support vector machines Proposes fuzzy logic to explain the uncertainties associated with diagnostic processes Provides data sets, sample signals, and MATLAB® code for algorithm testing Artificial Intelligence Tools: Decision Support Systems in Condition Monitoring and Diagnosis delivers a thorough evaluation of the latest AI tools for CM, describing the most common fault diagnosis techniques used and the data acquired when these techniques are applied.

Noninvasive monitoring of cancer therapy induced activated T cells using [18F]FB-IL-2 PET imaging

NARCIS (Netherlands)

Hartimath, S.V.; Draghiciu, O.; Wall, S. van de; Manuelli, V.; Dierckx, R.A.J.O.; Nijman, H.W.; Daemen, T.; Vries, E.F.J. de

2017-01-01

Cancer immunotherapy urgently calls for methods to monitor immune responses at the site of the cancer. Since activated T lymphocytes may serve as a hallmark for anticancer responses, we targeted these cells using the radiotracer N-(4-[18F]fluorobenzoyl)-interleukin-2 ([18F]FB-IL-2) for positron

Antiseptic solutions modulate the paracrine-like activity of bone chips: differential impact of chlorhexidine and sodium hypochlorite.

Science.gov (United States)

Sawada, Kosaku; Caballé-Serrano, Jordi; Bosshardt, Dieter D; Schaller, Benoit; Miron, Richard J; Buser, Daniel; Gruber, Reinhard

2015-09-01

Chemical decontamination increases the availability of bone grafts; however, it remains unclear whether antiseptic processing changes the biological activity of bone. Bone chips were incubated with four different antiseptic solutions including (1) povidone-iodine (0.5%), (2) chlorhexidine diguluconate (0.2%), (3) hydrogen peroxide (1%) and (4) sodium hypochlorite (0.25%). After 10 min. of incubation, changes in the capacity of the bone-conditioned medium (BCM) to modulate gene expression of gingival fibroblasts was investigated. Conditioned medium obtained from freshly prepared bone chips increased the expression of TGF-β target genes interleukin 11 (IL11), proteoglycan4 (PRG4), NADPH oxidase 4 (NOX4), and decreased the expression of adrenomedullin (ADM), and pentraxin 3 (PTX3) in gingival fibroblasts. Incubation of bone chips with 0.2% chlorhexidine, followed by vigorously washing resulted in a BCM with even higher expression of IL11, PRG4 and NOX4. These findings were also detected with a decrease in cell viability and an activation of apoptosis signalling. Chlorhexidine alone, at low concentrations, increased IL11, PRG4 and NOX4 expression, independent of the TGF-β receptor I kinase activity. In contrast, 0.25% sodium hypochlorite almost entirely abolished the activity of BCM, whereas the other two antiseptic solutions, 1% hydrogen peroxide and 0.5% povidone-iodine, had relatively no impact respectively. These in vitro findings demonstrate that incubation of bone chips with chlorhexidine differentially affects the activity of the respective BCM compared to the other antiseptic solutions. The data further suggest that the main effects are caused by chlorhexidine remaining in the BCM after repeated washing of the bone chips. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

77 FR 24228 - Condition Monitoring Techniques for Electric Cables Used in Nuclear Power Plants

Science.gov (United States)

2012-04-23

... Used in Nuclear Power Plants AGENCY: Nuclear Regulatory Commission. ACTION: Regulatory guide; issuance... guide, (RG) 1.218, ``Condition Monitoring Techniques for Electric Cables Used in Nuclear Power Plants... of electric cables for nuclear power plants. RG 1.218 is not intended to be prescriptive, instead it...

Improvements in valve reliability due to implementation of effective condition monitoring programs

International Nuclear Information System (INIS)

Hale, Stan

2003-01-01

Modern diagnostic systems for motor-operated valves, pneumatic control valves and checkvalves have facilitated a shift in the maintenance philosophy for valves and actuators in nuclear power plants from schedule based to condition-based maintenance (CBM). This shift enables plant management to focus resources and schedule priority on the plant equipment that warrants attention thereby not wasting resources or increasing the human factors risk on equipment that has not degraded. The most recent initiatives combine condition monitoring with risk/safety insights to focus attention and resonances on the right equipment at the right time consistent with each component's safety-significance. The activities of the ASME working groups responsible for nuclear O and M codes have kept pace with the technology and process improvements necessary to maximize the technical and economic benefits of condition based and risk informed maintenance. This paper discusses adoption of valve condition monitoring in the nuclear power industry, changes to ASME codes and standards during the 90's to facilitate adoption of condition monitoring technology for in-service testing and recent efforts to combine risk insights with condition monitoring strategies to achieve the highest level of valve reliability and nuclear safety without over inflating maintenance cost. (author)

Comparisons of [18F]-1-deoxy-1-fluoro-scyllo-inositol with [18F]-FDG for PET imaging of inflammation, breast and brain cancer xenografts in athymic mice

International Nuclear Information System (INIS)

McLarty, Kristin; Moran, Matthew D.; Scollard, Deborah A.; Chan, Conrad; Sabha, Nesrin; Mukherjee, Joydeep; Guha, Abhijit; McLaurin, JoAnne; Nitz, Mark; Houle, Sylvain; Wilson, Alan A.; Reilly, Raymond M.; Vasdev, Neil

2011-01-01

Introduction: The aim of the study was to evaluate the uptake of [ 18 F]-1-deoxy-1-fluoro-scyllo-inositol ([ 18 F]-scyllo-inositol) in human breast cancer (BC) and glioma xenografts, as well as in inflammatory tissue, in immunocompromised mice. Studies of [ 18 F]-2-fluoro-2-deoxy-D-glucose ([ 18 F]-FDG) under the same conditions were also performed. Methods: Radiosynthesis of [ 18 F]-scyllo-inositol was automated using a commercial synthesis module. Tumour, inflammation and normal tissue uptakes were evaluated by biodistribution studies and positron emission tomography (PET) imaging using [ 18 F]-scyllo-inositol and [ 18 F]-FDG in mice bearing subcutaneous MDA-MB-231, MCF-7 and MDA-MB-361 human BC xenografts, intracranial U-87 MG glioma xenografts and turpentine-induced inflammation. Results: The radiosynthesis of [ 18 F]-scyllo-inositol was automated with good radiochemical yields (24.6%±3.3%, uncorrected for decay, 65±2 min, n=5) and high specific activities (≥195 GBq/μmol at end of synthesis). Uptake of [ 18 F]-scyllo-inositol was greatest in MDA-MB-231 BC tumours and was comparable to that of [ 18 F]-FDG (4.6±0.5 vs. 5.5±2.1 %ID/g, respectively; P=.40), but was marginally lower in MDA-MB-361 and MCF-7 xenografts. Uptake of [ 18 F]-scyllo-inositol in inflammation was lower than [ 18 F]-FDG. While uptake of [ 18 F]-scyllo-inositol in intracranial U-87 MG xenografts was significantly lower than [ 18 F]-FDG, the tumour-to-brain ratio was significantly higher (10.6±2.5 vs. 2.1±0.6; P=.001). Conclusions: Consistent with biodistribution studies, uptake of [ 18 F]-scyllo-inositol was successfully visualized by PET imaging in human BC and glioma xenografts, with lower accumulation in inflammatory tissue than [ 18 F]-FDG. The tumour-to-brain ratio of [ 18 F]-scyllo-inositol was also significantly higher than that of [ 18 F]-FDG for visualizing intracranial glioma xenografts in NOD SCID mice, giving a better contrast. -- Graphical Abstract: Display Omitted

Economic analysis of condition monitoring systems for offshore wind turbine sub-systems

DEFF Research Database (Denmark)

May, Allan; MacMillan, David; Thöns, Sebastian

2015-01-01

The use of condition monitoring systems on offshore wind turbines has increased dramatically in recent times. However, their use is mostly restricted to vibration based monitoring systems for the gearbox, generator and drive train. A survey of commercially available condition monitoring systems...... year life cycle. The model uses Hidden Markov Models to represent both the actual system state and the observed condition monitoring state. The CM systems are modelled to include reduced failure types, false alarms, detection rates and 6 month failure warnings. The costs for system failures are derived...... and their associated costs has been completed for the blades, drive train, tower and foundation. This paper considers what value can be obtained from integrating these additional systems into the maintenance plan. This is achieved by running simulations on an operations and maintenance model for a wind farm over a 20...

Oscillations and waves in a spatially distributed system with a 1/f spectrum

Science.gov (United States)

Koverda, V. P.; Skokov, V. N.

2018-02-01

A spatially distributed system with a 1/f power spectrum is described by two nonlinear stochastic equations. Conditions for the formation of auto-oscillations have been found using numerical methods. The formation of a 1/f and 1/k spectrum simultaneously with the formation and motion of waves under the action of white noise has been demonstrated. The large extreme fluctuations with 1/f and 1/k spectra correspond to the maximum entropy, which points to the stability of such processes. It is shown that on the background of formation and motion of waves at an external periodic action there appears spatio-temporal stochastic resonance, at which one can observe the expansion of the region of periodic pulsations under the action of white noise.

More on Gopakumar-Vafa formula: coefficients F0 and F1

International Nuclear Information System (INIS)

Dedushenko, M.

2015-01-01

In Type IIA compactified on a Calabi-Yau threefold, the genus zero and one terms of the Gopakumar-Vafa (GV) formula describe F-terms that are related to genus zero and one topological amplitudes. While for higher-genus terms F g ,g≥2, the contribution of a light hypermultiplet can be computed via a sum over Kaluza-Klein harmonics, as has been shown in a recent paper, for g≤1, the sum diverges and it is better to compute F 0 and F 1 directly in five-dimensional field theory. Such a computation is presented here.

Monitoring Vasculitis with 18F-FDG PET

International Nuclear Information System (INIS)

Jan BUCERIUS, Jan

2016-01-01

Whereas in the past the term “vasculitis” was most frequently used in context with systemic vasculitides, such as the large vessel vasculitides (LVV) Takayasa arteritis and giant cell arteritis, characterized by inflammation of blood vessel walls, it nowadays comprises also inflammatory changes of the vessel wall as a substantial part of the atherosclerotic disease process. Implementing non-invasive imaging techniques, such as computed tomography angiography (CTA), magnetic resonance angiography (MRA) as well as positron emission tomography (PET) in the diagnostic algorithm of atherosclerosis and LVV, depicts a promising step towards an earlier detection with a, consecutively, improved therapeutic approach and potentially prognostic benefit in patients suffering from vasculitis. Mainly molecular imaging with 18F-fluorodeoxyglucose (FDG) PET seems to be promising in offering an early and sensitive identification of inflammatory changes in both, atherosclerosis and LVV. This review will therefore provide an overview on the diagnostic performance and clinical relevance of FDG-PET in monitoring vasculitis in atherosclerosis and LVV, with a focus on LVV.

Semi-supervised vibration-based classification and condition monitoring of compressors

Science.gov (United States)

Potočnik, Primož; Govekar, Edvard

2017-09-01

Semi-supervised vibration-based classification and condition monitoring of the reciprocating compressors installed in refrigeration appliances is proposed in this paper. The method addresses the problem of industrial condition monitoring where prior class definitions are often not available or difficult to obtain from local experts. The proposed method combines feature extraction, principal component analysis, and statistical analysis for the extraction of initial class representatives, and compares the capability of various classification methods, including discriminant analysis (DA), neural networks (NN), support vector machines (SVM), and extreme learning machines (ELM). The use of the method is demonstrated on a case study which was based on industrially acquired vibration measurements of reciprocating compressors during the production of refrigeration appliances. The paper presents a comparative qualitative analysis of the applied classifiers, confirming the good performance of several nonlinear classifiers. If the model parameters are properly selected, then very good classification performance can be obtained from NN trained by Bayesian regularization, SVM and ELM classifiers. The method can be effectively applied for the industrial condition monitoring of compressors.

E2F1 regulates cellular growth by mTORC1 signaling.

Directory of Open Access Journals (Sweden)

Sebastian Real

2011-01-01

Full Text Available During cell proliferation, growth must occur to maintain homeostatic cell size. Here we show that E2F1 is capable of inducing growth by regulating mTORC1 activity. The activation of cell growth and mTORC1 by E2F1 is dependent on both E2F1's ability to bind DNA and to regulate gene transcription, demonstrating that a gene induction expression program is required in this process. Unlike E2F1, E2F3 is unable to activate mTORC1, suggesting that growth activity could be restricted to individual E2F members. The effect of E2F1 on the activation of mTORC1 does not depend on Akt. Furthermore, over-expression of TSC2 does not interfere with the effect of E2F1, indicating that the E2F1-induced signal pathway can compensate for the inhibitory effect of TSC2 on Rheb. Immunolocalization studies demonstrate that E2F1 induces the translocation of mTORC1 to the late endosome vesicles, in a mechanism dependent of leucine. E2F1 and leucine, or insulin, together affect the activation of S6K stronger than alone suggesting that they are complementary in activating the signal pathway. From these studies, E2F1 emerges as a key protein that integrates cell division and growth, both of which are essential for cell proliferation.

Radiation Monitoring System in Advanced Spent Fuel Conditioning Process Facility

Energy Technology Data Exchange (ETDEWEB)

You, Gil Sung; Kook, D. H.; Choung, W. M.; Ku, J. H.; Cho, I. J.; You, G. S.; Kwon, K. C.; Lee, W. K.; Lee, E. P

2006-09-15

The Advanced spent fuel Conditioning Process is under development for effective management of spent fuel by converting UO{sub 2} into U-metal. For demonstration of this process, {alpha}-{gamma} type new hot cell was built in the IMEF basement . To secure against radiation hazard, this facility needs radiation monitoring system which will observe the entire operating area before the hot cell and service area at back of it. This system consists of 7 parts; Area Monitor for {gamma}-ray, Room Air Monitor for particulate and iodine in both area, Hot cell Monitor for hot cell inside high radiation and rear door interlock, Duct Monitor for particulate of outlet ventilation, Iodine Monitor for iodine of outlet duct, CCTV for watching workers and material movement, Server for management of whole monitoring system. After installation and test of this, radiation monitoring system will be expected to assist the successful ACP demonstration.

Radiation Monitoring System in Advanced Spent Fuel Conditioning Process Facility

International Nuclear Information System (INIS)

You, Gil Sung; Kook, D. H.; Choung, W. M.; Ku, J. H.; Cho, I. J.; You, G. S.; Kwon, K. C.; Lee, W. K.; Lee, E. P.

2006-09-01

The Advanced spent fuel Conditioning Process is under development for effective management of spent fuel by converting UO 2 into U-metal. For demonstration of this process, α-γ type new hot cell was built in the IMEF basement . To secure against radiation hazard, this facility needs radiation monitoring system which will observe the entire operating area before the hot cell and service area at back of it. This system consists of 7 parts; Area Monitor for γ-ray, Room Air Monitor for particulate and iodine in both area, Hot cell Monitor for hot cell inside high radiation and rear door interlock, Duct Monitor for particulate of outlet ventilation, Iodine Monitor for iodine of outlet duct, CCTV for watching workers and material movement, Server for management of whole monitoring system. After installation and test of this, radiation monitoring system will be expected to assist the successful ACP demonstration

Monitoring of Tumor Growth with [(18)F]-FET PET in a Mouse Model of Glioblastoma: SUV Measurements and Volumetric Approaches.

Science.gov (United States)

Holzgreve, Adrien; Brendel, Matthias; Gu, Song; Carlsen, Janette; Mille, Erik; Böning, Guido; Mastrella, Giorgia; Unterrainer, Marcus; Gildehaus, Franz J; Rominger, Axel; Bartenstein, Peter; Kälin, Roland E; Glass, Rainer; Albert, Nathalie L

2016-01-01

Noninvasive tumor growth monitoring is of particular interest for the evaluation of experimental glioma therapies. This study investigates the potential of positron emission tomography (PET) using O-(2-(18)F-fluoroethyl)-L-tyrosine ([(18)F]-FET) to determine tumor growth in a murine glioblastoma (GBM) model-including estimation of the biological tumor volume (BTV), which has hitherto not been investigated in the pre-clinical context. Fifteen GBM-bearing mice (GL261) and six control mice (shams) were investigated during 5 weeks by PET followed by autoradiographic and histological assessments. [(18)F]-FET PET was quantitated by calculation of maximum and mean standardized uptake values within a universal volume-of-interest (VOI) corrected for healthy background (SUVmax/BG, SUVmean/BG). A partial volume effect correction (PVEC) was applied in comparison to ex vivo autoradiography. BTVs obtained by predefined thresholds for VOI definition (SUV/BG: ≥1.4; ≥1.6; ≥1.8; ≥2.0) were compared to the histologically assessed tumor volume (n = 8). Finally, individual "optimal" thresholds for BTV definition best reflecting the histology were determined. In GBM mice SUVmax/BG and SUVmean/BG clearly increased with time, however at high inter-animal variability. No relevant [(18)F]-FET uptake was observed in shams. PVEC recovered signal loss of SUVmean/BG assessment in relation to autoradiography. BTV as estimated by predefined thresholds strongly differed from the histology volume. Strikingly, the individual "optimal" thresholds for BTV assessment correlated highly with SUVmax/BG (ρ = 0.97, p GBM mouse model. PVEC is beneficial to improve accuracy of [(18)F]-FET PET SUV quantification. Although SUVmax/BG and SUVmean/BG increase during the disease course, these parameters do not correlate with the respective tumor size. For the first time, we propose a histology-verified method allowing appropriate individual BTV estimation for volumetric in vivo monitoring of tumor growth

Condition monitoring through advanced sensor and computational technology

International Nuclear Information System (INIS)

Kim, Jung Taek; Hur, S.; Seong, S. H.; Hwang, Il Soon; Lee, Joon Hyun; You, Jun; Lee, Sang Jung

2004-01-01

In order to successfully implement the extended-life operation plan of the nuclear power plant (NPP), predictive maintenance based on on-line monitoring of deteriorated components becomes highly important. In this work, we present progresses in the development of an advanced monitoring system to detect the health condition on check valve failures and pipe wall-thinning phenomena. The failures of check valves have resulted in significant maintenance efforts, on occasion, have resulted in water hammer, over-pressurization of low-pressure systems, and damage to flow system components. Pipe wall-thinning is usually caused by Flow-Accelerated Corrosion (FAC) under the undesirable combination of water chemistry, flow velocity and material composition. A piping elbow in the moisture separator/reheater drain line on the secondary waterside of a PWR is chosen as a monitoring target

A bulk-controlled ring-VCO with 1/f-noise reduction for frequency ΔΣ modulator

DEFF Research Database (Denmark)

Tuan Vu, CAO; Wisland, Dag T.; Lande, Tor Sverre

The paper introduces a bulk-controlled ring-VCO with a tail transistor utilizing flicker-noise (1/f-noise) reduction techniques for a frequency-based DeltaSigma modulator (FDSM). This VCO converts an analog input voltage to phase information under various bias conditions ranging from sub-threshol......The paper introduces a bulk-controlled ring-VCO with a tail transistor utilizing flicker-noise (1/f-noise) reduction techniques for a frequency-based DeltaSigma modulator (FDSM). This VCO converts an analog input voltage to phase information under various bias conditions ranging from sub...

A calibration-free ammonia breath sensor using a quantum cascade laser with WMS 2f/1f

KAUST Repository

Owen, Kyle

2013-12-22

The amount of ammonia in exhaled breath has been linked to a variety of adverse medical conditions, including chronic kidney disease (CKD). The development of accurate, reliable breath sensors has the potential to improve medical care. Wavelength modulation spectroscopy with second harmonic normalized by the first harmonic (WMS 2f/1f) is a sensitive technique used in the development of calibration-free sensors. An ammonia gas sensor is designed and developed that uses a quantum cascade laser operating near 1,103.44 cm -1 and a multi-pass cell with an effective path length of 76.45 m. The sensor has a 7 ppbv detection limit and 5 % total uncertainty for breath measurements. The sensor was successfully used to detect ammonia in exhaled breath and compare healthy patients to patients diagnosed with CKD. © 2013 Springer-Verlag Berlin Heidelberg.

Congenital Hypopituitarism due to POU1F1 Gene Mutation

Directory of Open Access Journals (Sweden)

Ni-Chung Lee

2011-01-01

Full Text Available POU1F1 (Pit-1; Gene ID 5449 is an anterior pituitary transcriptional factor, and POU1F1 mutation is known to cause anterior pituitary hypoplasia, growth hormone and prolactin deficiency and various degree of hypothyroidism. We report here a patient who presented with growth failure and central hypothyroidism since early infancy. However, treatment with thyroxine gave no effect and he subsequently developed calf muscle pseudohypertrophy (Kocher-Debre-Semelaigne syndrome, elevation of creatinine kinase, dilated cardiomyopathy and pericardial effusion. Final diagnosis was made by combined pituitary function test and sequencing analysis that revealed POU1F1 gene C.698T > C (p.F233S mutation. The rarity of the disease can result in delayed diagnosis and treatment.

Larval development of Spodoptera eridania (Cramer fed on leaves of Bt maize expressing Cry1F and Cry1F + Cry1A.105 + Cry2Ab2 proteins and its non-Bt isoline

Directory of Open Access Journals (Sweden)

Orcial Ceolin Bortolotto

2015-03-01

Full Text Available This study aimed to evaluate, in controlled laboratory conditions (temperature of 25±2 °C, relative humidity of 60±10%, and 14/10 h L/D photoperiod, the larval development of Spodoptera eridania (Cramer, 1784 (Lepidoptera, Noctuidae fed with leaves of Bt maize expressing Cry1F and Cry1F + Cry1A.105 + Cry2Ab2 insecticide proteins and its non-Bt isoline. Maize leaves triggered 100% of mortality on S. eridania larvae independently of being Bt or non-Bt plants. However, it was observed that in overall Bt maize (expressing a single or pyramided protein slightly affects the larval development of S. eridania, even under reduced leaf consumption. Therefore, these results showed that Cry1F and Cry1F + Cry1A.105 + Cry2Ab2 can affect the larval development of S. eridania, although it is not a target pest of this plant; however, more research is needed to better understand this evidence. Finally, this study confirms that non-Bt maize leaves are unsuitable food source to S. eridania larvae, suggesting that they are not a potential pest in maize fields.

4th International Conference on Condition Monitoring of Machinery in Non-Stationary Operations

CERN Document Server

Zimroz, Radoslaw; Bartelmus, Walter; Haddar, Mohamed

2016-01-01

The book provides readers with a snapshot of recent research and technological trends in the field of condition monitoring of machinery working under a broad range of operating conditions. Each chapter, accepted after a rigorous peer-review process, reports on an original piece of work presented and discussed at the 4th International Conference on Condition Monitoring of Machinery in Non-stationary Operations, CMMNO 2014, held on December 15-16, 2014, in Lyon, France. The contributions have been grouped into three different sections according to the main subfield (signal processing, data mining, or condition monitoring techniques) they are related to. The book includes both theoretical developments as well as a number of industrial case studies, in different areas including, but not limited to: noise and vibration; vibro-acoustic diagnosis; signal processing techniques; diagnostic data analysis; instantaneous speed identification; monitoring and diagnostic systems; and dynamic and fault modeling. This book no...

2003F1季中评点

Institute of Scientific and Technical Information of China (English)

东临; DarrenHeath

2003-01-01

目前2003赛季过半，20位F1车手中，谁的表现最佳？谁最尽力？由全球20位F1资深人士组成的F1 Racing测评小组对今季F1所有参赛车手做出评定。这次的评分结果相当接近。甚至可能会引起争论。

A Wavelet Bicoherence-Based Quadratic Nonlinearity Feature for Translational Axis Condition Monitoring

Directory of Open Access Journals (Sweden)

Yong Li

2014-01-01

Full Text Available The translational axis is one of the most important subsystems in modern machine tools, as its degradation may result in the loss of the product qualification and lower the control precision. Condition-based maintenance (CBM has been considered as one of the advanced maintenance schemes to achieve effective, reliable and cost-effective operation of machine systems, however, current vibration-based maintenance schemes cannot be employed directly in the translational axis system, due to its complex structure and the inefficiency of commonly used condition monitoring features. In this paper, a wavelet bicoherence-based quadratic nonlinearity feature is proposed for translational axis condition monitoring by using the torque signature of the drive servomotor. Firstly, the quadratic nonlinearity of the servomotor torque signature is discussed, and then, a biphase randomization wavelet bicoherence is introduced for its quadratic nonlinear detection. On this basis, a quadratic nonlinearity feature is proposed for condition monitoring of the translational axis. The properties of the proposed quadratic nonlinearity feature are investigated by simulations. Subsequently, this feature is applied to the real-world servomotor torque data collected from the X-axis on a high precision vertical machining centre. All the results show that the performance of the proposed feature is much better than that of original condition monitoring features.

Breath acetone to monitor life style interventions in field conditions: an exploratory study.

Science.gov (United States)

Samudrala, Devasena; Lammers, Gerwen; Mandon, Julien; Blanchet, Lionel; Schreuder, Tim H A; Hopman, Maria T; Harren, Frans J M; Tappy, Luc; Cristescu, Simona M

2014-04-01

To assess whether breath acetone concentration can be used to monitor the effects of a prolonged physical activity on whole body lipolysis and hepatic ketogenesis in field conditions. Twenty-three non-diabetic, 11 type 1 diabetic, and 17 type 2 diabetic subjects provided breath and blood samples for this study. Samples were collected during the International Four Days Marches, in the Netherlands. For each participant, breath acetone concentration was measured using proton transfer reaction ion trap mass spectrometry, before and after a 30-50 km walk on four consecutive days. Blood non-esterified free fatty acid (NEFA), beta-hydroxybutyrate (BOHB), and glucose concentrations were measured after walking. Breath acetone concentration was significantly higher after than before walking, and was positively correlated with blood NEFA and BOHB concentrations. The effect of walking on breath acetone concentration was repeatedly observed on all four consecutive days. Breath acetone concentrations were higher in type 1 diabetic subjects and lower in type 2 diabetic subjects than in control subjects. Breath acetone can be used to monitor hepatic ketogenesis during walking under field conditions. It may, therefore, provide real-time information on fat burning, which may be of use for monitoring the lifestyle interventions. Copyright © 2014 The Obesity Society.

Magnetic activity effect on equatorial spread-F under high and low solar activity conditions

Energy Technology Data Exchange (ETDEWEB)

Subbarao, K S.V.; Somayajulu, V V; Krishna Murthy, B V

1986-08-01

The effect of magnetic activity on spread-F at two equatorial stations, Trivandrum and Huancayo, separated in longitude by about 150 deg, under high and low solar activity conditions has been investigated. Magnetic activity produces strong inhibition effect on spread-F at Huancayo compared to that at Trivandrum especially during high solar activity period. This results in a decrease of spread-F with solar activity at Huancayo in contrast to Trivandrum. These findings are explained in terms of F-region electrodynamics and Rayleigh-Taylor instability mechanism for spread-F.

Non-stationary Condition Monitoring of large diesel engines with the AEWATT toolbox

DEFF Research Database (Denmark)

Pontoppidan, Niels Henrik; Larsen, Jan; Sigurdsson, Sigurdur

2005-01-01

We are developing a specialized toolbox for non-stationary condition monitoring of large 2-stroke diesel engines based on acoustic emission measurements. The main contribution of this toolbox has so far been the utilization of adaptive linear models such as Principal and Independent Component Ana......, the inversion of those angular timing changes called “event alignment”, has allowed for condition monitoring across operation load settings, successfully enabling a single model to be used with realistic data under varying operational conditions-...

Mimic sensor to monitor condition of human health; Mimic sensor wo riyoshita taicho monitoring

Energy Technology Data Exchange (ETDEWEB)

Nagata, Y. [Mechanical Engineering Lab., Tokyo (Japan)

2000-04-01

In the aging society where the birth rate decreases and the number of nuclear families increases, it is very important to inquire after the aged or physically handicapped people, to monitor their physical conditions, and to take steps to keep them healthy. As for the in-home physical measurement for the aged or physically handicapped people and the work of health management for them based on such measurement, it is feared that under the present conditions the invalid themselves or their family members or nurses will inevitably have to bear the burden and that nobody can deny the difficulty of continuing such nursing care. If daily physical condition measurement and related data collection are automatically carried out, however, interested people' burden will lessen and in-home heath management will become actually feasible. In this paper, a mimic sensor for realizing such a situation is described, which will measure physical conditions without interfering with the daily life of interested people. Serving as the mimic sensor is a blood flow sensor embedded in a telephone receiver, and changes in the blood flow during telephone conversation and changes in the gaps between peeks will be monitored. The feasibility is shown of continual collection of information necessary for the measurement of physical conditions of the aged or physically handicapped persons. (NEDO)

System for monitoring microclimate conditions in greenhouse

Directory of Open Access Journals (Sweden)

Marković Dušan B.

2014-01-01

Full Text Available Monitoring microclimate parameters in different kind of environments has significant contribution to many areas of human activity and production processes. One of them is vegetable production in greenhouses where measurement of its microclimate parameters may influence the decision on taking appropriate action and protect crops. It is also important to preserve optimal condition in greenhouses to facilitate the process of transpiration, plant mineral nutrition and prevent of a variety physiological damage caused by a deficit of some specific nutrients. Systems for monitoring have wide application in the last years thanks to development of modern computer technology. In this paper model of the monitoring system based on smart transducer concept was introduced. Within the system components are based on MSP430 ultra low power micro controllers. They are using wireless communication to exchange data within the system that was structured according to smart transducer concept. User applications from the network could access to system interface using HTTP protocol where web server could be running on the computer or it could be an embedded web server running on micro controller based device.

Condition Monitoring Using Computational Intelligence Methods Applications in Mechanical and Electrical Systems

CERN Document Server

Marwala, Tshilidzi

2012-01-01

Condition monitoring uses the observed operating characteristics of a machine or structure to diagnose trends in the signal being monitored and to predict the need for maintenance before a breakdown occurs. This reduces the risk, inherent in a fixed maintenance schedule, of performing maintenance needlessly early or of having a machine fail before maintenance is due either of which can be expensive with the latter also posing a risk of serious accident especially in systems like aeroengines in which a catastrophic failure would put lives at risk. The technique also measures responses from the whole of the system under observation so it can detect the effects of faults which might be hidden deep within a system, hidden from traditional methods of inspection. Condition Monitoring Using Computational Intelligence Methods promotes the various approaches gathered under the umbrella of computational intelligence to show how condition monitoring can be used to avoid equipment failures and lengthen its useful life, m...

Image edge detection based tool condition monitoring with morphological component analysis.

Science.gov (United States)

Yu, Xiaolong; Lin, Xin; Dai, Yiquan; Zhu, Kunpeng

2017-07-01

The measurement and monitoring of tool condition are keys to the product precision in the automated manufacturing. To meet the need, this study proposes a novel tool wear monitoring approach based on the monitored image edge detection. Image edge detection has been a fundamental tool to obtain features of images. This approach extracts the tool edge with morphological component analysis. Through the decomposition of original tool wear image, the approach reduces the influence of texture and noise for edge measurement. Based on the target image sparse representation and edge detection, the approach could accurately extract the tool wear edge with continuous and complete contour, and is convenient in charactering tool conditions. Compared to the celebrated algorithms developed in the literature, this approach improves the integrity and connectivity of edges, and the results have shown that it achieves better geometry accuracy and lower error rate in the estimation of tool conditions. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

Insulinoma imaging with glucagon-like peptide-1 receptor targeting probe (18)F-FBEM-Cys (39)-exendin-4.

Science.gov (United States)

Xu, Yuping; Pan, Donghui; Xu, Qing; Zhu, Chen; Wang, Lizhen; Chen, Fei; Yang, Runlin; Luo, Shineng; Yang, Min

2014-09-01

Glucagon-like peptide-1 receptor (GLP-1R) is a specific target for insulinomas imaging since it is overexpressed in the tumor. Exendin-4 exhibits high affinity for the GLP-1R. In this study, a novel (18)F-labeled exendin-4 analog, (18)F-FBEM-Cys(39)-exendin-4, was synthesized and its potentials for GLP-1R imaging were also evaluated. (18)F-FBEM was synthesized by coupling (18)F-fluorobenzoic acid ((18)F-FBA) with N-(2-aminoethyl) maleimide, and the reaction conditions were optimized. Cys(39)-exendin-4 was then conjugated with (18)F-FBEM to obtain (18)F-FBEM-Cys(39)-exendin-4. The GLP-1R targeting potential and pharmacokinetic profile of the tracer were analyzed in INS-1 insulinoma and MDA-MB-435 breast tumor model, respectively. Under the optimal conditions, the yield of radiolabeled (18)F-FBEM was 49.1 ± 2.0 % (based on (18)F-FBA, non-decay corrected). The yield of (18)F-FBEM-Cys(39)-exendin-4 was 35.1 ± 2.6 % (based on the starting (18)F-FBEM, non-decay corrected). The radiochemical purity of (18)F-FBEM-Cys(39)-exendin-4 is >95 %, and the specific activity was at least 35 GBq/μmol. The GLP-1R-positive INS-1 insulinoma xenograft was clearly visible with good contrast to background, whereas GLP-1R-negative MDA-MB435 breast tumor was barely visible. Low levels of radioactivity were also detected at pancreas and lungs due to few GLP-1R expressions. GLP-1R binding specificity was demonstrated by reduced INS-1 tumor uptake of the tracer after coinjection with an excess of unlabeled Cys(39)-exendin-4 at 1 h postinjection. The thiol-reactive reagent, (18)F-FBEM, was prepared with high yield and successfully conjugated to Cys(39)-exendin-4. Favorable preclinical data showing specific and effective tumor targeting by (18)F-FBEM-Cys(39)-exendin-4 suggest that the tracer may be a potential probe for insulinomas imaging.

A real time study on condition monitoring of distribution transformer using thermal imager

Science.gov (United States)

Mariprasath, T.; Kirubakaran, V.

2018-05-01

The transformer is one of the critical apparatus in the power system. At any cost, a few minutes of outages harshly influence the power system. Hence, prevention-based maintenance technique is very essential. The continuous conditioning and monitoring technology significantly increases the life span of the transformer, as well as reduces the maintenance cost. Hence, conditioning and monitoring of transformer's temperature are very essential. In this paper, a critical review has been made on various conditioning and monitoring techniques. Furthermore, a new method, hot spot indication technique, is discussed. Also, transformer's operating condition is monitored by using thermal imager. From the thermal analysis, it is inferred that major hotspot locations are appearing at connection lead out; also, the bushing of the transformer is the very hottest spot in transformer, so monitoring the level of oil is essential. Alongside, real time power quality analysis has been carried out using the power analyzer. It shows that industrial drives are injecting current harmonics to the distribution network, which causes the power quality problem on the grid. Moreover, the current harmonic limit has exceeded the IEEE standard limit. Hence, the adequate harmonics suppression technique is need an hour.

Congenital hypopituitarism due to POU1F1 gene mutation.

Science.gov (United States)

Lee, Ni-Chung; Tsai, Wen-Yu; Peng, Shinn-Forng; Tung, Yi-Ching; Chien, Yin-Hsiu; Hwu, Wuh-Liang

2011-01-01

POU1F1 (Pit-1; Gene ID 5449) is an anterior pituitary transcriptional factor, and POU1F1 mutation is known to cause anterior pituitary hypoplasia, growth hormone and prolactin deficiency and various degree of hypothyroidism. We report here a patient who presented with growth failure and central hypothyroidism since early infancy. However, treatment with thyroxine gave no effect and he subsequently developed calf muscle pseudohypertrophy (Kocher-Debre-Semelaigne syndrome), elevation of creatinine kinase, dilated cardiomyopathy and pericardial effusion. Final diagnosis was made by combined pituitary function test and sequencing analysis that revealed POU1F1 gene C.698T > C (p.F233S) mutation. The rarity of the disease can result in delayed diagnosis and treatment. Copyright © 2011 Formosan Medical Association & Elsevier. Published by Elsevier B.V. All rights reserved.

The DBP Phenotype Gc-1f/Gc-1f Is Associated with Reduced Risk of Cancer. The Tromsø Study.

Directory of Open Access Journals (Sweden)

Rolf Jorde

Full Text Available In addition to its role as a transport protein, the vitamin D binding protein (DBP may also affect lipid metabolism, inflammation and carcinogenesis. There are three common variants of the DBP, Gc1s (1s, Gc1f (1f, Gc2 (2 that result in six common phenotypes (1s/1s, 1s/1f, 1s/2, 1f/1f, 1f/2, and 2/2. These phenotypes can be identified by genotyping for the two single nucleotide polymorphisms rs7041 and rs4588 in the GC gene. The DBP variants have different binding coefficients for the vitamin D metabolites, and accordingly there may be important relations between DBP phenotypes and health.DNA was prepared from subjects who participated in the fourth survey of the Tromsø Study in 1994-1995 and who were registered with the endpoints myocardial infarction (MI, type 2 diabetes (T2DM, cancer or death as well as a randomly selected control group. The endpoint registers were complete up to 2010- 2013. Genotyping was performed for rs7041 and rs4588 and serum 25-hydroxyvitamin D (25(OHD was measured.Genotyping for rs7041 and rs4588 was performed successfully in 11 704 subjects. Among these, 1660 were registered with incident MI, 958 with T2DM, 2410 with cancer and 4318 had died. Subjects with the DBP phenotype 1f/1f had 23 - 26 % reduced risk of incident cancer compared to the 1s/1s and 2/2 phenotypes (P < 0.02, Cox regression with gender as covariate. Differences in serum 25(OHD levels could not explain the apparent cancer protective effect of the DBP variant 1f. In addition to cancer and 25(OHD, there were significant associations between DBP phenotype and body height, hip circumference and serum calcium.There are important biological differences between the common DBP phenotypes. If the relation between the DBP variant 1f and cancer is confirmed in other studies, determination of DBP phenotype may have clinical importance.

Remote condition-based monitoring of turbines

International Nuclear Information System (INIS)

2005-01-01

specific point in time; Timewave: Amount of motion and symmetry of wave shape (i.e., a truncated wave can be an indication of a rub); Orbits: A cross-sectional view of shaft movement; DC Gap Voltage: A measurement of the distance (e.g., gap) between the shaft and the proximity probes. This value is useful in determining bearing wear of shaft centerline location. Daily monitoring of these metrics will not only warn of impending failure, but provide valuable information regarding the possible cause of the impending failure and an approximate indication of time to failure. In the event of a sudden problem and subsequent trip of a turbine, this data helps determine the root cause of the failure. This results in faster problem resolution and a quicker restart of the turbine. Additionally, daily monitoring of these metrics allows companies to watch a problematic turbine's health until the next scheduled outage. Azima's remote, condition-based monitoring system and diagnostics service is an effective way to collect and trend these metrics on a daily basis, as well as supply expert advice in the event of any anomalies. The Azima system aggregates the analog data from the proximity probes mounted on the turbine at a sensor hub. The sensor hub digitizes the analog data and then, either wirelessly or through a wired Ethernet connection, sends the data via the Internet to a hosted server. The hosted server maintains the software that trends the data (e.g., vibration, spectrum, timewave, DC gap voltage, and orbits) and provides automatic alerting. The data can be accessed anywhere, anytime through a standard Web browser. The advantages of daily, remote, condition-based monitoring include: Daily monitoring of vital turbine health metrics to detect impending problems before they become critical; Automatic alerting when a change in condition is detected; Anywhere, anytime access via a standard Web browser. This allows multiple groups at different locations to simultaneously review and

A Review of the Condition Monitoring of Capacitors in Power Electronic Converters

DEFF Research Database (Denmark)

Soliman, Hammam Abdelaal Hammam; Wang, Huai; Blaabjerg, Frede

2015-01-01

Capacitor is one of the reliability critical components in power electronic systems. In the last two decades, many efforts in the academic research have been devoted to the condition monitoring of capacitors to estimate their health status. Industry applications demand more reliable power...... electronics products with preventive maintenance. Nevertheless, most of the developed capacitor condition monitoring technologies are rarely adopted by industry due to the complexity, increased cost and other relevant issues. An overview of the prior-art research in this area is therefore needed to justify....... Therefore, this paper firstly classifies the capacitor condition monitoring methods into three categories, then the respective technology evolution from 1993 to 2015 is summarized. Remarks on the state-of-the-art research and the future opportunities targeting for practical industry applications are given....

A Review of the Condition Monitoring of Capacitors in Power Electronic Converters

DEFF Research Database (Denmark)

Soliman, Hammam Abdelaal Hammam; Wang, Huai; Blaabjerg, Frede

2016-01-01

Capacitors are one type of reliability-critical components in power electronic systems. In the last two decades, many efforts in academic research have been devoted to the condition monitoring of capacitors to estimate their health status. Industry applications are demanding more reliable power...... electronics products with preventive maintenance. Nevertheless, most of the developed capacitor condition monitoring technologies are rarely adopted by industry due to the complexity, increased cost, and other relevant issues. An overview of the prior-art research in this area is therefore needed to justify......, this paper first classifies the capacitor condition monitoring methods into three categories, then the respective technology evolution in the last two decades is summarized. Finally, the state-of-the-art research and the future opportunities targeting for industry applications are given....

1/f noise: diffusive systems and music

Energy Technology Data Exchange (ETDEWEB)

Voss, R.F.

1975-11-01

Measurements of the 1/f voltage noise in continuous metal films are reported. At room temperature, samples of pure metals and bismuth (with a carrier density smaller by 10/sup 5/) of similar volume had comparable noise. The results suggest that the noise arises from equilibrium temperature fluctuations modulating the resistance. Spatial correlation of the noise implied that the fluctuations obey a diffusion equation. The empirical inclusion of an explicit 1/f region and appropriate normalization lead to excellent agreement with the measured noise. If the fluctuations are assumed to be spatially correlated, the diffusion equation can yield an extended 1/f region in the power spectrum. The temperature response of a sample to delta and step function power inputs is shown to have the same shape as the autocorrelation function for uncorrelated and correlated temperature fluctuations, respectively. The spectrum obtained from the cosine transform of the measured step function response is in excellent agreement with the measured 1/f voltage noise spectrum. Spatially correlated equilibrium temperature fluctuations are not the dominant source of 1/f noise in semiconductors and metal films. However, the agreement between the low-frequency spectrum of fluctuations in the mean-square Johnson noise voltage and the resistance fluctuation spectrum measured in the presence of a current demonstrates that in these systems the 1/f noise is also due to equilibrium resistance fluctuations. Loudness fluctuations in music and speech and pitch fluctuations in music also show the 1/f behavior. 1/f noise sources, consequently, are demonstrated to be the natural choice for stochastic composition. 26 figures, 1 table. (auth)

Laboratory versus industrial cutting force sensor in tool condition monitoring system

International Nuclear Information System (INIS)

Szwajka, K

2005-01-01

Research works concerning the utilisation of cutting force measures in tool condition monitoring usually present results and deliberations based on laboratory sensors. These sensors are too fragile to be used in industrial practice. Industrial sensors employed on the factory floor are less accurate, and this must be taken into account when creating a tool condition monitoring strategy. Another drawback of most of these works is that constant cutting parameters are used for the entire tool life. This does not reflect industrial practice where the same tool is used at different feeds and depths of cut in sequential passes. This paper presents a comparison of signals originating from laboratory and industrial cutting force sensors. The usability of the sensor output was studied during a laboratory simulation of industrial cutting conditions. Instead of building mathematical models for the correlation between tool wear and cutting force, an FFBP artificial neural network was used to find which combination of input data would provide an acceptable estimation of tool wear. The results obtained proved that cross talk between channels has an important influence on cutting force measurements, however this input configuration can be used for a tool condition monitoring system

Trypanosoma brucei TbIF1 inhibits the essential F1-ATPase in the infectious form of the parasite.

Directory of Open Access Journals (Sweden)

Brian Panicucci

2017-04-01

Full Text Available The mitochondrial (mt FoF1-ATP synthase of the digenetic parasite, Trypanosoma brucei, generates ATP during the insect procyclic form (PF, but becomes a perpetual consumer of ATP in the mammalian bloodstream form (BF, which lacks a canonical respiratory chain. This unconventional dependence on FoF1-ATPase is required to maintain the essential mt membrane potential (Δψm. Normally, ATP hydrolysis by this rotary molecular motor is restricted to when eukaryotic cells experience sporadic hypoxic conditions, during which this compulsory function quickly depletes the cellular ATP pool. To protect against this cellular treason, the highly conserved inhibitory factor 1 (IF1 binds the enzyme in a manner that solely inhibits the hydrolytic activity. Intriguingly, we were able to identify the IF1 homolog in T. brucei (TbIF1, but determined that its expression in the mitochondrion is tightly regulated throughout the life cycle as it is only detected in PF cells. TbIF1 appears to primarily function as an emergency brake in PF cells, where it prevented the restoration of the Δψm by FoF1-ATPase when respiration was chemically inhibited. In vitro, TbIF1 overexpression specifically inhibits the hydrolytic activity but not the synthetic capability of the FoF1-ATP synthase in PF mitochondria. Furthermore, low μM amounts of recombinant TbIF1 achieve the same inhibition of total mt ATPase activity as the FoF1-ATPase specific inhibitors, azide and oligomycin. Therefore, even minimal ectopic expression of TbIF1 in BF cells proved lethal as the indispensable Δψm collapsed due to inhibited FoF1-ATPase. In summary, we provide evidence that T. brucei harbors a natural and potent unidirectional inhibitor of the vital FoF1-ATPase activity that can be exploited for future structure-based drug design.

Non-invasive glucagon-like peptide-1 receptor imaging in pancreas with (18)F-Al labeled Cys(39)-exendin-4.

Science.gov (United States)

Mi, Baoming; Xu, Yuping; Pan, Donghui; Wang, Lizhen; Yang, Runlin; Yu, Chunjing; Wan, Weixing; Wu, Yiwei; Yang, Min

2016-02-26

Glucagon-like peptide-1 receptor (GLP-1R) is abundantly expressed on beta cells and may be an ideal target for the pancreas imaging. Monitoring the GLP-1R of pancreas could be benefit for understanding the pathophysiology of diabetes. In the present study, (18)F-Al labeled exendin-4 analog, (18)F-Al-NOTA-MAL-Cys(39)-exendin-4, was evaluated for PET imaging GLP-1R in the pancreas. The targeting of (18)F-Al labeled exendin-4 analog was examined in healthy and streptozotocin induced diabetic rats. Rats were injected with (18)F-Al-NOTA-MAL-Cys(39)-exendin-4 and microPET imaging was performed at 1 h postinjection, followed by ex vivo biodistribution. GLP-1R expression in pancreas was determined through post mortern examinations. The pancreas of healthy rats was readily visualized after administration of (18)F-Al-NOTA-MAL-Cys(39)-exendin-4, whereas the pancreas of diabetic rats, as well as those from rats co-injected with excess of unlabeled peptides, was barely visible by microPET. At 60 min postinjection, the pancreatic uptakes were 1.02 ± 0.15%ID/g and 0.23 ± 0.05%ID/g in healthy and diabetic rats respectively. Under block, the pancreatic uptakes of non-diabetic rats reduced to 0.21 ± 0.07%ID/g at the same time point. Biodistribution data and IHC staining confirmed the findings of the microPET imaging. The favorable preclinical data indicated that (18)F-Al-NOTA-MAL-Cys(39)-exendin-4may be suitable for non-invasive monitoring functional pancreatic beta cells. Copyright © 2016 Elsevier Inc. All rights reserved.

Comparisons of [{sup 18}F]-1-deoxy-1-fluoro-scyllo-inositol with [{sup 18}F]-FDG for PET imaging of inflammation, breast and brain cancer xenografts in athymic mice

Energy Technology Data Exchange (ETDEWEB)

McLarty, Kristin; Moran, Matthew D. [Department of Psychiatry, University of Toronto, Toronto, ON, M5T 1R8 (Canada); PET Centre, Centre for Addiction and Mental Health, Toronto, ON, M5T 1R8 (Canada); Scollard, Deborah A.; Chan, Conrad [Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON, M5S 3M2 (Canada); Sabha, Nesrin; Mukherjee, Joydeep; Guha, Abhijit [Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, ON, M5G 1X8 (Canada); McLaurin, JoAnne [Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, M5S 3H2 (Canada); Nitz, Mark [Department of Chemistry, University of Toronto, Toronto, ON, M5S 3H6 (Canada); Houle, Sylvain; Wilson, Alan A. [Department of Psychiatry, University of Toronto, Toronto, ON, M5T 1R8 (Canada); PET Centre, Centre for Addiction and Mental Health, Toronto, ON, M5T 1R8 (Canada); Reilly, Raymond M., E-mail: raymond.reilly@utoronto.ca [Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON, M5S 3M2 (Canada); Toronto General Research Institute, University Health Network, Toronto, ON, M5G 2M9 (Canada); Department of Medical Imaging, University of Toronto, Toronto, ON, M5S 3M2 (Canada); Vasdev, Neil, E-mail: neil.vasdev@utoronto.ca [Department of Psychiatry, University of Toronto, Toronto, ON, M5T 1R8 (Canada); PET Centre, Centre for Addiction and Mental Health, Toronto, ON, M5T 1R8 (Canada)

2011-10-15

Introduction: The aim of the study was to evaluate the uptake of [{sup 18}F]-1-deoxy-1-fluoro-scyllo-inositol ([{sup 18}F]-scyllo-inositol) in human breast cancer (BC) and glioma xenografts, as well as in inflammatory tissue, in immunocompromised mice. Studies of [{sup 18}F]-2-fluoro-2-deoxy-D-glucose ([{sup 18}F]-FDG) under the same conditions were also performed. Methods: Radiosynthesis of [{sup 18}F]-scyllo-inositol was automated using a commercial synthesis module. Tumour, inflammation and normal tissue uptakes were evaluated by biodistribution studies and positron emission tomography (PET) imaging using [{sup 18}F]-scyllo-inositol and [{sup 18}F]-FDG in mice bearing subcutaneous MDA-MB-231, MCF-7 and MDA-MB-361 human BC xenografts, intracranial U-87 MG glioma xenografts and turpentine-induced inflammation. Results: The radiosynthesis of [{sup 18}F]-scyllo-inositol was automated with good radiochemical yields (24.6%{+-}3.3%, uncorrected for decay, 65{+-}2 min, n=5) and high specific activities ({>=}195 GBq/{mu}mol at end of synthesis). Uptake of [{sup 18}F]-scyllo-inositol was greatest in MDA-MB-231 BC tumours and was comparable to that of [{sup 18}F]-FDG (4.6{+-}0.5 vs. 5.5{+-}2.1 %ID/g, respectively; P=.40), but was marginally lower in MDA-MB-361 and MCF-7 xenografts. Uptake of [{sup 18}F]-scyllo-inositol in inflammation was lower than [{sup 18}F]-FDG. While uptake of [{sup 18}F]-scyllo-inositol in intracranial U-87 MG xenografts was significantly lower than [{sup 18}F]-FDG, the tumour-to-brain ratio was significantly higher (10.6{+-}2.5 vs. 2.1{+-}0.6; P=.001). Conclusions: Consistent with biodistribution studies, uptake of [{sup 18}F]-scyllo-inositol was successfully visualized by PET imaging in human BC and glioma xenografts, with lower accumulation in inflammatory tissue than [{sup 18}F]-FDG. The tumour-to-brain ratio of [{sup 18}F]-scyllo-inositol was also significantly higher than that of [{sup 18}F]-FDG for visualizing intracranial glioma xenografts in

Condition monitoring of main coolant pumps, Dhruva

International Nuclear Information System (INIS)

Prasad, V.; Satheesh, C.; Acharya, V.N.; Tikku, A.C.; Mishra, S.K.

2002-01-01

Full text: Dhruva is a 100 MW research reactor with natural uranium fuel, heavy water as moderator and primary coolant. Three Centrifugal pumps circulate the primary coolant across the core and the heat exchangers. Each pump is coupled to a flywheel (FW) assembly in order to meet operational safety requirements. All the 3 main coolant pump (MCP) sets are required to operate during operation of the reactor. The pump-sets are in operation since the year 1984 and have logged more than 1,00,000 hrs. Frequent breakdowns of its FW bearings were experienced during initial years of operation. Condition monitoring of these pumps, largely on vibration based parameters, was initiated on regular basis. Break-downs of main coolant pumps reduced considerably due to the fair accurate predictions of incipient break-downs and timely maintenance efforts. An effort is made in this paper to share the experience

"1"8F-FBPA as a tumor-specific probe of L-type amino acid transporter 1 (LAT1): a comparison study with "1"8F-FDG and "1"1C-Methionine PET

International Nuclear Information System (INIS)

Watabe, Tadashi; Ikeda, Hayato; Aoki, Masanao; Nagamori, Shushi; Wiriyasermkul, Pattama; Tanaka, Yoko; Hagiwara, Kohei; Kanai, Yoshikatsu; Naka, Sadahiro; Kanai, Yasukazu; Shimosegawa, Eku; Hatazawa, Jun

2017-01-01

The purpose of this study was to evaluate the usefulness of L-4-borono-2-"1"8F-fluoro-phenylalanine ("1"8F-FBPA) as a tumor-specific probe, in comparison to "1"8F-FDG and "1"1C-methionine (Met), focusing on its transport selectivity by L-type amino acid transporter 1 (LAT1), which is highly upregulated in cancers. Cellular analyses of FBPA were performed to evaluate the transportability and K_m value. PET studies were performed in rat xenograft models of C6 glioma (n = 12) and in rat models of turpentine oil-induced subcutaneous inflammation (n = 9). The kinetic parameters and uptake values on static PET images were compared using the one-tissue compartment model (K_1, k_2) and maximum standardized uptake value (SUVmax). The cellular analyses showed that FBPA had a lower affinity to a normal cell-type transporter LAT2 and induced less efflux through LAT2 among FBPA, Met, and BPA, while the efflux through LAT1 induced by FBPA was similar among the three compounds. The K_m value of "1"8F-FBPA for LAT1 (196.8 ± 11.4 μM) was dramatically lower than that for LAT2 (2813.8 ± 574.5 μM), suggesting the higher selectivity of "1"8F-FBPA for LAT1. K_1 and k_2 values were significantly smaller in "1"8F-FBPA PET (K_1 = 0.04 ± 0.01 ml/ccm/min and k_2 = 0.07 ± 0.01 /min) as compared to "1"1C-Met PET (0.22 ± 0.09 and 0.52 ± 0.10, respectively) in inflammatory lesions. Static PET analysis based on the SUVmax showed significantly higher accumulation of "1"8F-FDG in the tumor and inflammatory lesions (7.2 ± 2.1 and 4.6 ± 0.63, respectively) as compared to both "1"8F-FBPA (3.2 ± 0.40 and 1.9 ± 0.19) and "1"1C-Met (3.4 ± 0.43 and 1.6 ± 0.11). No significant difference was observed between "1"8F-FBPA and "1"1C-Met in the static PET images. This study shows the utility of "1"8F-FBPA as a tumor-specific probe of LAT1 with low accumulation in the inflammatory lesions. (orig.)

An intelligent condition monitoring system for on-line classification of machine tool wear

Energy Technology Data Exchange (ETDEWEB)

Pan, Fu; Hope, A D; Javed, M [Systems Engineering Faculty, Southampton Institute (United Kingdom)

1998-12-31

The development of intelligent tool condition monitoring systems is a necessary requirement for successful automation of manufacturing processes. This presentation introduces a tool wear monitoring system for milling operations. The system utilizes power, force, acoustic emission and vibration sensors to monitor tool condition comprehensively. Features relevant to tool wear are drawn from time and frequency domain signals and a fuzzy pattern recognition technique is applied to combine the multisensor information and provide reliable classification results of tool wear states. (orig.) 10 refs.

An intelligent condition monitoring system for on-line classification of machine tool wear

Energy Technology Data Exchange (ETDEWEB)

Fu Pan; Hope, A.D.; Javed, M. [Systems Engineering Faculty, Southampton Institute (United Kingdom)

1997-12-31

The development of intelligent tool condition monitoring systems is a necessary requirement for successful automation of manufacturing processes. This presentation introduces a tool wear monitoring system for milling operations. The system utilizes power, force, acoustic emission and vibration sensors to monitor tool condition comprehensively. Features relevant to tool wear are drawn from time and frequency domain signals and a fuzzy pattern recognition technique is applied to combine the multisensor information and provide reliable classification results of tool wear states. (orig.) 10 refs.

Monitoring machining conditions by analyzing cutting force vibration

Energy Technology Data Exchange (ETDEWEB)

Piao, Chun Guang; Kim, Ju Wan; Kim, Jin Oh; Shin, Yoan [Soongsl University, Seoul (Korea, Republic of)

2015-09-15

This paper deals with an experimental technique for monitoring machining conditions by analyzing cutting-force vibration measured at a milling machine. This technique is based on the relationship of the cutting-force vibrations with the feed rate and cutting depth as reported earlier. The measurement system consists of dynamic force transducers and a signal amplifier. The analysis system includes an oscilloscope and a computer with a LabVIEW program. Experiments were carried out at various feed rates and cutting depths, while the rotating speed was kept constant. The magnitude of the cutting force vibration component corresponding to the number of cutting edges multiplied by the frequency of rotation was linearly correlated with the machining conditions. When one condition of machining is known, another condition can be identified by analyzing the cutting-force vibration.

Monitoring machining conditions by analyzing cutting force vibration

International Nuclear Information System (INIS)

Piao, Chun Guang; Kim, Ju Wan; Kim, Jin Oh; Shin, Yoan

2015-01-01

This paper deals with an experimental technique for monitoring machining conditions by analyzing cutting-force vibration measured at a milling machine. This technique is based on the relationship of the cutting-force vibrations with the feed rate and cutting depth as reported earlier. The measurement system consists of dynamic force transducers and a signal amplifier. The analysis system includes an oscilloscope and a computer with a LabVIEW program. Experiments were carried out at various feed rates and cutting depths, while the rotating speed was kept constant. The magnitude of the cutting force vibration component corresponding to the number of cutting edges multiplied by the frequency of rotation was linearly correlated with the machining conditions. When one condition of machining is known, another condition can be identified by analyzing the cutting-force vibration

Effect of Animal Condition and Fluvoxamine on the Result of [{sup 18F}]N 3 Fluoropropyl-2{beta} carbomethoxy-3{beta} (4-iodophenyl) Nortropane ([{sup 18F}]FP-CIT) PET Study in Mice

Energy Technology Data Exchange (ETDEWEB)

Shin, Kwang Ho; Lee Sang Ju; Oh, Seung Jun; Kim, Jae Seung [Asan Medical Center, Univ. of Ulsan College of Medicine, Seoul (Korea, Republic of); Park, Su A [Ulsan National Institute of Science and Technology, Ulsan (Korea, Republic of); Kim, Seog Young [Univ. of Pittsburgh, Pittaburg (United States)

2012-03-15

PET (positron emission tomography) is a noninvasive imaging technique, visualizing biological aspects in vivo. In animal models, the result of PET study can be affected more prominently than in humans by the animal conditions or drug pretreatment. We assessed the effects of anesthesia, body temperature, and pretreatment with selective serotonin reuptake inhibitor on the results of [{sup 18F}]N 3 fluoropropyl 2{beta} carbomethoxy 3{beta} (4-iodophenyl) nortropane ([{sup 18F}]FP CIT) PET in mice. [{sup 18F}]FP CIT PET of C57BL/6 mice was performed in three different conditions: (1) anesthesia (isoflurane) with active warming (38.deg.C) as a reference; (2) no anesthesia or warming; (3) anesthesia without warming at room temperature. Additional groups of mine pretreated with escalating doses of fluvoxamine (5, 20, 40, 80 mg/kg) were imaged in condition (1). The time activity curve and standardized uptake value of the striatum, cerebral cortex, and bone were compared among these conditions. In all conditions, radioactivities of the striatum and cortex tended to form a plateau after rapid uptake and washout, but that of bone tended to increase gradually. When anesthetized without any warming, all the mice developed hypothermia and showed reduced bone uptake compared to the reference condition. In conditions without anesthesia, striatal and cortical uptakes compared to the reference condition. In conditions without anesthesia, striatal and cortical uptakes were reduced, whereas the bone uptake showed no change. Pretreatment with fluvoxamine increased the striatal uptake and striatal specific to cortical non specific uptake ratio, whereas the bone uptake was reduced. Anesthesia, body temperature, and fluvoxamine affect the result of [{sup 18F}]FP CIT PET in mice by altering striatal and bone uptakes.

Two-step photoconductivity in LiY x Lu1 - x F4:Ce,Yb crystals

Science.gov (United States)

Nurtdinova, L. A.; Korableva, S. L.; Leontiev, A. V.

2016-10-01

Photoconductivity of LiY x Lu1- x F4:Ce,Yb ( x = 0-1) crystals is measured under one- and two-step excitation. It is established that the photoconductivity is due to intra-center transitions from excited states of Ce3+ ions. The position of the ground 4 f-state of Ce3+ ion relative to the bottom of the conduction band is determined. The choice of pumping conditions to obtain the lasing on the 5 d-4 f transitions of trivalent cerium in these active media is substantiated.

Cleanup Verification Package for the 126-F-1, 184-F Powerhouse Ash Pit

International Nuclear Information System (INIS)

Clark, S.W.; Sulloway, H.M.

2007-01-01

This cleanup verification package documents completion of remedial action for the 126-F-1, 184-F Powerhouse Ash Pit. This waste site received coal ash from the 100-F Area coal-fired steam plant. Leakage of process effluent from the 116-F-14 , 107-F Retention Basins flowed south into the ash pit, contaminating the northern portion

Condition monitoring and maintenance of nuclear power plant concrete structures

International Nuclear Information System (INIS)

Orr, R.; Prasad, N.

1988-01-01

Nuclear power plant concrete structures are potentially subject to deterioration due to several environmental conditions, including weather exposure, ground water exposure, and sustained high temperature and radiation levels. The nuclear power plant are generally licensed for a term of 40 years. In order to maximize the return from the existing plants, feasibility studies are in progress for continued operation of many of these plants beyond the original licensed life span. This paper describes a study that was performed with an objective to define appropriate condition monitoring and maintenance procedures. A timely implementation of a condition monitoring and maintenance program would provide a valuable database and would provide justification for extension of the plant's design life. The study included concrete structures such as the containment buildings, interior structures, basemats, intake structures and cooling towers. Age-related deterioration at several operating power plants was surveyed and the potential degradation mechanisms have been identified

Surface Acoustic Wave (SAW Resonators for Monitoring Conditioning Film Formation

Directory of Open Access Journals (Sweden)

Siegfried Hohmann

2015-05-01

Full Text Available We propose surface acoustic wave (SAW resonators as a complementary tool for conditioning film monitoring. Conditioning films are formed by adsorption of inorganic and organic substances on a substrate the moment this substrate comes into contact with a liquid phase. In the case of implant insertion, for instance, initial protein adsorption is required to start wound healing, but it will also trigger immune reactions leading to inflammatory responses. The control of the initial protein adsorption would allow to promote the healing process and to suppress adverse immune reactions. Methods to investigate these adsorption processes are available, but it remains difficult to translate measurement results into actual protein binding events. Biosensor transducers allow user-friendly investigation of protein adsorption on different surfaces. The combination of several transduction principles leads to complementary results, allowing a more comprehensive characterization of the adsorbing layer. We introduce SAW resonators as a novel complementary tool for time-resolved conditioning film monitoring. SAW resonators were coated with polymers. The adsorption of the plasma proteins human serum albumin (HSA and fibrinogen onto the polymer-coated surfaces were monitored. Frequency results were compared with quartz crystal microbalance (QCM sensor measurements, which confirmed the suitability of the SAW resonators for this application.

A case study of remaining storage life prediction using stochastic filtering with the influence of condition monitoring

International Nuclear Information System (INIS)

Wang, Zhaoqiang; Hu, Changhua; Wang, Wenbin; Zhou, Zhijie; Si, Xiaosheng

2014-01-01

Some systems may spend most of their time in storage, but once needed, must be fully functional. Slow degradation occurs when the system is in storage, so to ensure the functionality of these systems, condition monitoring is usually conducted periodically to check the condition of the system. However, taking the condition monitoring data may require putting the system under real testing situation which may accelerate the degradation, and therefore, shorten the storage life of the system. This paper presents a case study of condition-based remaining storage life prediction for gyros in the inertial navigation system on the basis of the condition monitoring data and the influence of the condition monitoring data taking process. A stochastic-filtering-based degradation model is developed to incorporate both into the prediction of the remaining storage life distribution. This makes the predicted remaining storage life depend on not only the condition monitoring data but also the testing process of taking the condition monitoring data, which the existing prognostic techniques and algorithms did not consider. The presented model is fitted to the real condition monitoring data of gyros testing using the maximum likelihood estimation method for parameter estimation. Comparisons are made with the model without considering the process of taking the condition monitoring data, and the results clearly demonstrate the superiority of the newly proposed model

Coherent and conventional gravidynamic quantum 1/f noise

Science.gov (United States)

Handel, Peter H.; George, Thomas F.

2008-04-01

Quantum 1/f noise is a fundamental fluctuation of currents, physical cross sections or process rates, caused by infrared coupling of the current carriers to very low frequency (soft) quanta, also known as infraquanta. The latter are soft gravitons in the gravidynamic case with the coupling constant g= pGM2/Nch considered here -- soft photons in the electrodynamic case and soft transversal piezo-phonons in the lattice-dynamical case. Here p=3.14 and F=psi. Quantum 1/f noise is a new aspect of quantum mechanics expressed mainly through the coherent quantum 1/f effect 2g/pf derived here for large systems, and mainly through the conventional quantum 1/f effect for small systems or individual particles. Both effects are present in general, and their effects are superposed in a first approximation with the help of a coherence (weight) parameter s" that will be derived elsewhere for the gravitational case. The spectral density of fractional fluctuations S(dj/j,f) for j=e(hk/2pm)|F|2 is S(F2,f)/ = S(j,f)/2 = [4ps"/(1+s")]GM2/pfNch = 4.4 10E9 M2/(pfNgram2). Here s" = 2N'GM/c2=N'rs, where N' is the number of particles of mass M per unit length of the current, rs their Schwarzschild radius, and s" is our coherence (weight) parameter giving the ratio of coherent to conventional quantum 1/f contributions.

Wind Turbine Condition Monitoring Strategy through Multiway PCA and Multivariate Inference

Directory of Open Access Journals (Sweden)

Francesc Pozo

2018-03-01

Full Text Available This article states a condition monitoring strategy for wind turbines using a statistical data-driven modeling approach by means of supervisory control and data acquisition (SCADA data. Initially, a baseline data-based model is obtained from the healthy wind turbine by means of multiway principal component analysis (MPCA. Then, when the wind turbine is monitorized, new data is acquired and projected into the baseline MPCA model space. The acquired SCADA data are treated as a random process given the random nature of the turbulent wind. The objective is to decide if the multivariate distribution that is obtained from the wind turbine to be analyzed (healthy or not is related to the baseline one. To achieve this goal, a test for the equality of population means is performed. Finally, the results of the test can determine that the hypothesis is rejected (and the wind turbine is faulty or that there is no evidence to suggest that the two means are different, so the wind turbine can be considered as healthy. The methodology is evaluated on a wind turbine fault detection benchmark that uses a 5 MW high-fidelity wind turbine model and a set of eight realistic fault scenarios. It is noteworthy that the results, for the presented methodology, show that for a wide range of significance, α ∈ [ 1 % , 13 % ] , the percentage of correct decisions is kept at 100%; thus it is a promising tool for real-time wind turbine condition monitoring.

Condition Monitoring Through Advanced Sensor and Computational Technology

International Nuclear Information System (INIS)

Kim, Jung Taek; Park, Won Man; Kim, Jung Soo; Seong, Soeng Hwan; Hur, Sub; Cho, Jae Hwan; Jung, Hyung Gue

2005-05-01

The overall goal of this joint research project was to develop and demonstrate advanced sensors and computational technology for continuous monitoring of the condition of components, structures, and systems in advanced and next-generation nuclear power plants (NPPs). This project included investigating and adapting several advanced sensor technologies from Korean and US national laboratory research communities, some of which were developed and applied in non-nuclear industries. The project team investigated and developed sophisticated signal processing, noise reduction, and pattern recognition techniques and algorithms. The researchers installed sensors and conducted condition monitoring tests on two test loops, a check valve (an active component) and a piping elbow (a passive component), to demonstrate the feasibility of using advanced sensors and computational technology to achieve the project goal. Acoustic emission (AE) devices, optical fiber sensors, accelerometers, and ultrasonic transducers (UTs) were used to detect mechanical vibratory response of check valve and piping elbow in normal and degraded configurations. Chemical sensors were also installed to monitor the water chemistry in the piping elbow test loop. Analysis results of processed sensor data indicate that it is feasible to differentiate between the normal and degraded (with selected degradation mechanisms) configurations of these two components from the acquired sensor signals, but it is questionable that these methods can reliably identify the level and type of degradation. Additional research and development efforts are needed to refine the differentiation techniques and to reduce the level of uncertainties

Intelligent condition monitoring of railway catenary systems : A Bayesian Network approach

NARCIS (Netherlands)

Wang, H.; Nunez Vicencio, Alfredo; Dollevoet, R.P.B.J.; Liu, Zhigang; Chen, Junwen; Spiryagin, Maksym; Gordon, Timothy; Cole, Colin; McSweeney, Tim

2017-01-01

This study proposes a Bayesian network (BN) dedicated for the intelligent condition monitoring of railway catenary systems. It combines five types of measurements related to catenary condition, namely the contact wire stagger, contact wire height, pantograph head displacement, pantograph head

Wireless condition monitoring for the RA-6 research reactor

International Nuclear Information System (INIS)

Garcia Peyrano, O.; Calzeta, O.; Rico, N.; Damiani, H.; Coutsiers, E.

1999-01-01

The vibration laboratory at C.A.B. has a great experience with the analysis and diagnostic of symptoms of failures in the rotating equipment of the R-6 research reactor and in our longest NPP (CANDU 600 Mw), located in Embalse town, Cordoba City, Argentina. Objective: The standard condition monitoring instrumentation system were designed for large equipment operating under different environmental conditions and sensitivities. The signal processing is not flexible and the diagnostic is an expensive method for the small poll type research reactors. This papers describes the research and development which are related whit the new concept, cheaper and flexible condition monitoring instrumentation system. Implementing a vibration analysis measurements technique with a sensor inside (in the pool) of the nuclear reactor RA-6, and mainly based on fft signal processing, an extensive program for vibration source identification was done. Different nuclear power conditions were monitored as full power and in zero power, also. This zero power shows the best acoustical environmental, because the cooling pumps are stop, and the core is cooling by natural convection. Two sensors were mainly used as the detector's subsystem. One of these detectors was an accelerometer attached to the top of the fine control rod and the other one was a water resistant omnidirectional microphone which was located underwater at different distances from the nuclear core. All the signal measurement by this two sensors were recorded and then was processed. Both signal was acquired at the same time for correlation analysis purposes. The analysis was composed by a 'Spectral Dynamics SD380' connected to a P.C. with dedicated post processing software. On the other hand, some calibration and sensitivity comparison was done using an SKFCM40, dual channel data collector and analyzer. (author)

26 CFR 1.665(f)-1A - Undistributed capital gain.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Undistributed capital gain. 1.665(f)-1A Section... Beginning on Or After January 1, 1969 § 1.665(f)-1A Undistributed capital gain. (a) Domestic trusts. (1) The term undistributed capital gain means (in the case of a trust other than a foreign trust created by a U...

Imaging grafted cells with [18F]FHBG using an optimized HSV1-TK mammalian expression vector in a brain injury rodent model.

Directory of Open Access Journals (Sweden)

Anne-Sophie Salabert

Full Text Available Cell transplantation is an innovative therapeutic approach after brain injury to compensate for tissue damage. To have real-time longitudinal monitoring of intracerebrally grafted cells, we explored the feasibility of a molecular imaging approach using thymidine kinase HSV1-TK gene encoding and [18F]FHBG as a reporter probe to image enzyme expression.A stable neuronal cell line expressing HSV1-TK was developed with an optimised mammalian expression vector to ensure long-term transgene expression. After [18F]FHBG incubation under defined parameters, calibration ranges from 1 X 104 to 3 X 106 Neuro2A-TK cells were analysed by gamma counter or by PET-camera. In parallel, grafting with different quantities of [18F]FHBG prelabelled Neuro2A-TK cells was carried out in a rat brain injury model induced by stereotaxic injection of malonate toxin. Image acquisition of the rats was then performed with PET/CT camera to study the [18F]FHBG signal of transplanted cells in vivo.Under the optimised incubation conditions, [18F]FHBG cell uptake rate was around 2.52%. In-vitro calibration range analysis shows a clear linear correlation between the number of cells and the signal intensity. The PET signal emitted into rat brain correlated well with the number of cells injected and the number of surviving grafted cells was recorded via the in-vitro calibration range. PET/CT acquisitions also allowed validation of the stereotaxic injection procedure. Technique sensitivity was evaluated under 5 X 104 grafted cells in vivo. No [18F]FHBG or [18F]metabolite release was observed showing a stable cell uptake even 2 h post-graft.The development of this kind of approach will allow grafting to be controlled and ensure longitudinal follow-up of cell viability and biodistribution after intracerebral injection.

Instrumentation for status monitoring and protection of SST-1 superconducting magnets

Energy Technology Data Exchange (ETDEWEB)

Sharma, A.N., E-mail: aashoo.sharma@yahoo.com; Prasad, U.; Doshi, K.; Varmora, P.; Khristi, Y.; Patel, D.; Pradhan, S.

2016-11-15

Highlights: • Details of status monitoring instrumentation are presented. • Protection instrumentation details are presented. • Instrumentation installation details, signal conditioning and DAQ system details and the results during SST-1 operation are presented. - Abstract: Superconducting magnets of SST-1 are extensively instrumented to continuously monitor the health of magnets during machine cool-down, plasma experiments and also during the machine warm-up phase. These instrumentations include temperature sensors, flow meters, hall probes, strain gages, displacement sensors, pressure sensors and voltage taps. The number of sensors and their locations has been optimized to systematically monitor all important magnet parameters to ensure its safety. In-house developed modular signal conditioning cards have been developed for these instrumentations. The data is acquired on a Versa Module Europa bus based data acquisition system (VME DAQ). This paper gives an overview of selection, installation, laboratory scale validations, and distribution logics of these instrumentations. Results during plasma campaigns and the up-gradation aspects of these instrumentations are also discussed in this paper.

40 CFR 141.621 - Routine monitoring.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Routine monitoring. 141.621 Section....621 Routine monitoring. (a) Monitoring. (1) If you submitted an IDSE report, you must begin monitoring..., you must monitor at the location(s) and dates identified in your monitoring plan in § 141.132(f...

ASSESSMENT OF CABLE AGING USING CONDITION MONITORING TECHNIQUES

International Nuclear Information System (INIS)

GROVE, E.; LOFARO, R.; SOO, P.; VILLARAN, M.; HSU, F.

2000-01-01

Electric cables in nuclear power plants suffer degradation during service as a result of the thermal and radiation environments in which they are installed. Instrumentation and control cables are one type of cable that provide an important role in reactor safety. Should the polymeric cable insulation material become embrittled and cracked during service, or during a loss-of-coolant-accident (LOCA) and when steam and high radiation conditions are anticipated, failure could occur and prevent the cables from fulfilling their intended safety function(s). A research program is being conducted at Brookhaven National Laboratory to evaluate condition monitoring (CM) techniques for estimating the amount of cable degradation experienced during in-plant service. The objectives of this program are to assess the ability of the cables to perform under a simulated LOCA without losing their ability to function effectively, and to identify CM techniques which may be used to determine the effective lifetime of cables. The cable insulation materials tested include ethylene propylene rubber (EPR) and cross-linked polyethylene (XLPE). Accelerated aging (thermal and radiation) to the equivalent of 40 years of service was performed, followed by exposure to simulated LOCA conditions. The effectiveness of chemical, electrical, and mechanical condition monitoring techniques are being evaluated. Results indicate that several of these methods can detect changes in material parameters with increasing age. However, each has its limitations, and a combination of methods may provide an effective means for trending cable degradation in order to assess the remaining life of cables

Task 1. Monitoring real time materials degradation. NRC extended In-situ and real-time Monitoring

Energy Technology Data Exchange (ETDEWEB)

Bakhtiari, Sasan [Argonne National Lab. (ANL), Argonne, IL (United States)

2012-03-01

The overall objective of this project was to perform a scoping study to identify, in concert with the nuclear industry, those sensors and techniques that have the most promising commercial viability and fill a critical inspection or monitoring need. Candidates to be considered include sensors to monitor real-time material degradation, characterize residual stress, monitor and inspect component fabrication, assess radionuclide and associated chemical species concentrations in ground water and soil, characterize fuel properties, and monitor severe accident conditions. Under Task 1—Monitoring Real-Time Materials Degradation—scoping studies were conducted to assess the feasibility of potential inspection and monitoring technologies (i.e., a combination of sensors, advanced signal processing techniques, and data analysis methods) that could be utilized in LWR and/or advanced reactor applications for continuous monitoring of degradation in-situ. The goal was to identify those techniques that appear to be the most promising, i.e., those that are closest to being both technically and commercially viable and that the nuclear industry is most likely to pursue. Current limitations and associated issues that must be overcome before commercial application of certain techniques have also been addressed.

Wind Turbine Gearbox Condition Monitoring with AAKR and Moving Window Statistic Methods

OpenAIRE

Peng Guo; Nan Bai

2011-01-01

Condition Monitoring (CM) of wind turbines can greatly reduce the maintenance costs for wind farms, especially for offshore wind farms. A new condition monitoring method for a wind turbine gearbox using temperature trend analysis is proposed. Autoassociative Kernel Regression (AAKR) is used to construct the normal behavior model of the gearbox temperature. With a proper construction of the memory matrix, the AAKR model can cover the normal working space for the gearbox. When the gearbox has a...

On-line Cutting Tool Condition Monitoring in Machining Processes Using Artificial Intelligence

OpenAIRE

Vallejo, Antonio J.; Morales-Menéndez, Rub&#;n; Alique, J.R.

2008-01-01

This chapter presented new ideas for monitoring and diagnosis of the cutting tool condition with two different algorithms for pattern recognition: HMM, and ANN. The monitoring and diagnosis system was implemented for peripheral milling process in HSM, where several Aluminium alloys and cutting tools were used. The flank wear (VB) was selected as the criterion to evaluate the tool's life and four cutting tool conditions were defined to be recognized: New, half new, half worn, and worn conditio...

On-line condition monitoring of nuclear systems via symbolic time series analysis

International Nuclear Information System (INIS)

Rajagopalan, V.; Ray, A.; Garcia, H. E.

2006-01-01

This paper provides a symbolic time series analysis approach to fault diagnostics and condition monitoring. The proposed technique is built upon concepts from wavelet theory, symbolic dynamics and pattern recognition. Various aspects of the methodology such as wavelet selection, choice of alphabet and determination of depth of D-Markov Machine are explained in the paper. The technique is validated with experiments performed in a Machine Condition Monitoring (MCM) test bed at the Idaho National Laboratory. (authors)

Single-Molecule Analysis of the Rotation of F1-ATPase under High Hydrostatic Pressure

Science.gov (United States)

Okuno, Daichi; Nishiyama, Masayoshi; Noji, Hiroyuki

2013-01-01

F1-ATPase is the water-soluble part of ATP synthase and is an ATP-driven rotary molecular motor that rotates the rotary shaft against the surrounding stator ring, hydrolyzing ATP. Although the mechanochemical coupling mechanism of F1-ATPase has been well studied, the molecular details of individual reaction steps remain unclear. In this study, we conducted a single-molecule rotation assay of F1 from thermophilic bacteria under various pressures from 0.1 to 140 MPa. Even at 140 MPa, F1 actively rotated with regular 120° steps in a counterclockwise direction, showing high conformational stability and retention of native properties. Rotational torque was also not affected. However, high hydrostatic pressure induced a distinct intervening pause at the ATP-binding angles during continuous rotation. The pause was observed under both ATP-limiting and ATP-saturating conditions, suggesting that F1 has two pressure-sensitive reactions, one of which is evidently ATP binding. The rotation assay using a mutant F1(βE190D) suggested that the other pressure-sensitive reaction occurs at the same angle at which ATP binding occurs. The activation volumes were determined from the pressure dependence of the rate constants to be +100 Å3 and +88 Å3 for ATP binding and the other pressure-sensitive reaction, respectively. These results are discussed in relation to recent single-molecule studies of F1 and pressure-induced protein unfolding. PMID:24094404

Phylodynamics of HIV-1 subtype F1 in Angola, Brazil and Romania.

Science.gov (United States)

Bello, Gonzalo; Afonso, Joana Morais; Morgado, Mariza G

2012-07-01

The HIV-1 subtype F1 is exceptionally prevalent in Angola, Brazil and Romania. The epidemiological context in which the spread of HIV occurred was highly variable from one country to another, mainly due to the existence of a long-term civil war in Angola and the contamination of a large number of children in Romania. Here we apply phylogenetic and Bayesian coalescent-based methods to reconstruct the phylodynamic patterns of HIV-1 subtype F1 in such different epidemiological settings. The phylogenetic analyses of HIV-1 subtype F1 pol sequences sampled worldwide confirmed that most sequences from Angola, Brazil and Romania segregated in country-specific monophyletic groups, while most subtype F1 sequences from Romanian children branched as a monophyletic sub-cluster (Romania-CH) nested within sequences from adults. The inferred time of the most recent common ancestor of the different subtype F1 clades were as follow: Angola=1983 (1978-1989), Brazil=1977 (1972-1981), Romania adults=1980 (1973-1987), and Romania-CH=1985 (1978-1989). All subtype F1 clades showed a demographic history best explained by a model of logistic population growth. Although the expansion phase of subtype F1 epidemic in Angola (mid 1980s to early 2000s) overlaps with the civil war period (1975-2002), the mean estimated growth rate of the Angolan F1 clade (0.49 year(-1)) was not exceptionally high, but quite similar to that estimated for the Brazilian (0.69 year(-1)) and Romanian adult (0.36 year(-1)) subtype F1 clades. The Romania-CH subtype F1 lineage, by contrast, displayed a short and explosive dissemination phase, with a median growth rate (2.47 year(-1)) much higher than that estimated for adult populations. This result supports the idea that the AIDS epidemic that affected the Romanian children was mainly caused by the spread of the HIV through highly efficient parenteral transmission networks, unlike adult populations where HIV is predominantly transmitted through sexual route. Copyright �

Statement of Basis/Proposed Plan for the F-Area Burning/Rubble Pits (231-F, 231-1F, and 231-2F)

International Nuclear Information System (INIS)

Palmer, E.

1996-08-01

The purpose of this source unit Statement of Basis/Proposed Plan is to describe the preferred alternative for addressing the F-Area Burning/Rubble Pits (231-F and 231-1F) and Rubble Pit (231-2F) (FBRP) source unit located at SRS, in southwestern Aiken County, South Carolina and to provide an opportunity for public input into the remedial action selection process

Magnetic anisotropy of cobalt nanoparticle 2D arrays grown on corrugated MnF{sub 2}(1 1 0) and CaF{sub 2}(1 1 0) surfaces

Energy Technology Data Exchange (ETDEWEB)

Baranov, D.A., E-mail: dbaranov@mail.ioffe.ru [Ioffe Physical-Technical Institute, Russian Academy of Sciences, 26 Polytechnicheskaya str., St. Petersburg 194021 (Russian Federation); Krichevtsov, B.B.; Gastev, S.V.; Banschikov, A.G.; Fedorov, V.V. [Ioffe Physical-Technical Institute, Russian Academy of Sciences, 26 Polytechnicheskaya str., St. Petersburg 194021 (Russian Federation); Koshmak, K.V. [Ioffe Physical-Technical Institute, Russian Academy of Sciences, 26 Polytechnicheskaya str., St. Petersburg 194021 (Russian Federation); Dipartimento di Ingegneria dei Materiali e dell’Ambiente, Università di Modena e Reggio Emilia, Via Vignolese 905, 41100 Modena (Italy); Suturin, S.M.; Sokolov, N.S. [Ioffe Physical-Technical Institute, Russian Academy of Sciences, 26 Polytechnicheskaya str., St. Petersburg 194021 (Russian Federation)

2013-02-15

Cobalt nanoparticle 2D arrays with different effective thicknesses of cobalt layer (2 nm < d{sub eff} < 10 nm) were grown by molecular beam epitaxy on CaF{sub 2}(1 1 0)/Si(0 0 1) and MnF{sub 2}(1 1 0)/CaF{sub 2}(1 1 0)/Si(0 0 1) substrates with corrugated morphology of the surface. Surface morphology analysis showed that for effective thickness of cobalt layer d{sub eff} = 5 nm the lateral dimensions of cobalt islands are about 5–10 nm and the distances between the islands differs in a half along and across the grooves. In both types of the heterostructures the shape of hysteresis loops measured by LMOKE depend on orientation of in-plane magnetic field relative to the direction of the grooves. The azimuthal dependence of coercive field H{sub c} in Co/CaF{sub 2}(1 1 0)/Si(0 0 1) structures corresponds to Stoner–Wohlfarth model's predictions, which takes into account the anisotropy of individual particles. In contrast to that, in Co/MnF{sub 2}(1 1 0)/CaF{sub 2}(1 1 0)/Si(0 0 1) structures these dependences are analogous to those predicted by the model based on account of magnetic–dipole interaction between particles which are placed in chains (chain-of-spheres-model). Possible explanations of the difference in magnetic anisotropy are suggested.

26 CFR 1.514(f)-1 - Definition of business lease.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Definition of business lease. 1.514(f)-1 Section... § 1.514(f)-1 Definition of business lease. (a) In general. The term business lease means any lease... extension, the lease shall be considered a 3-year lease and hence does not meet the definition of a business...

Condition Monitoring Of Operating Pipelines With Operational Modal Analysis Application

OpenAIRE

Mironov Aleksey; Doronkin Pavel; Priklonsky Aleksander; Kabashkin Igor

2015-01-01

In the petroleum, natural gas and petrochemical industries, great attention is being paid to safety, reliability and maintainability of equipment. There are a number of technologies to monitor, control, and maintain gas, oil, water, and sewer pipelines. The paper focuses on operational modal analysis (OMA) application for condition monitoring of operating pipelines. Special focus is on the topicality of OMA for definition of the dynamic features of the pipeline (frequencies and mode shapes) i...

Parametric Instability, Inverse Cascade, and the 1/f Range of Solar-Wind Turbulence.

Science.gov (United States)

Chandran, Benjamin D G

2018-02-01

In this paper, weak turbulence theory is used to investigate the nonlinear evolution of the parametric instability in 3D low- β plasmas at wavelengths much greater than the ion inertial length under the assumption that slow magnetosonic waves are strongly damped. It is shown analytically that the parametric instability leads to an inverse cascade of Alfvén wave quanta, and several exact solutions to the wave kinetic equations are presented. The main results of the paper concern the parametric decay of Alfvén waves that initially satisfy e + ≫ e - , where e + and e - are the frequency ( f ) spectra of Alfvén waves propagating in opposite directions along the magnetic field lines. If e + initially has a peak frequency f 0 (at which fe + is maximized) and an "infrared" scaling f p at smaller f with -1 scaling throughout a range of frequencies that spreads out in both directions from f 0 . At the same time, e - acquires an f -2 scaling within this same frequency range. If the plasma parameters and infrared e + spectrum are chosen to match conditions in the fast solar wind at a heliocentric distance of 0.3 astronomical units (AU), then the nonlinear evolution of the parametric instability leads to an e + spectrum that matches fast-wind measurements from the Helios spacecraft at 0.3 AU, including the observed f -1 scaling at f ≳ 3 × 10 -4 Hz. The results of this paper suggest that the f -1 spectrum seen by Helios in the fast solar wind at f ≳ 3 × 10 -4 Hz is produced in situ by parametric decay and that the f -1 range of e + extends over an increasingly narrow range of frequencies as r decreases below 0.3 AU. This prediction will be tested by measurements from the Parker Solar Probe .

Groundwater detection monitoring system design under conditions of uncertainty

NARCIS (Netherlands)

Yenigül, N.B.

2006-01-01

Landfills represent a wide-spread and significant threat to groundwater quality. In this thesis a methodology was developed for the design of optimal groundwater moni-toring system design at landfill sites under conditions of uncertainty. First a decision analysis approach was presented for optimal

Three State-of-the-Art Methods for Condition Monitoring

NARCIS (Netherlands)

Grimmelius, H.T.; Meiler, P.P.; Maas, H.L.M.M.; Bonnier, B.; Grevink, J.S.; Kuilenburg, R.F. van

1999-01-01

This paper describes and compares three different state-of-the-art condition monitoring techniques: first principles, feature extraction, and neural networks. The focus of the paper is on the application of the techniques, not on the underlying theory. Each technique is described briefly and is

Condition monitoring of pumps with co-relating field observations

International Nuclear Information System (INIS)

Mishra, S.K.; Prasad, V.; Sharma, R.B.

1994-01-01

The maintenance of 40 MWth research reactor, Cirus has been carried out for over 30 years following the time based maintenance schedule. With the commissioning of indigenously built 100 MWth nuclear research reactor Dhruva in the year 1985, a systematic work on condition monitoring has been commissioned. Apart from process parameters, which are recorded on hourly basis, vibration, noise, temperature, kurtosis etc. are measured for assessment of condition of pumps. The bearings of flywheel assembly of main pumps, Dhruva broke down almost abruptly during the initial years after first commissioning. The regular measurements of vibration level and kurtosis have greatly helped in avoiding breakdown. In a recent case one newly procured herringbone gear box (300 hp, 1475/1760 rpm) for the primary coolant pump was showing high vibration. In further checking using Fast Fourier Transform (FFT) analyser in a time domain plot the gear teeth damage was indicated. The pump was shut down for inspection and when the gear box was dismantled teeth were found broken. An attempt has been made in this paper to discuss a few interesting field experiences with condition monitoring and correlating field observations on pumps. (author). 3 figs

^2H(^18F,p)^19F Study at 6 MeV/u

Science.gov (United States)

Kozub, R. L.; Nesaraja, C. D.; Moazen, B. H.; Scott, J. P.; Bardayan, D. W.; Blackmon, J. C.; Gross, C. J.; Shapira, D.; Smith, M. S.; Batchelder, J. C.; Brune, C. R.; Champagne, A. E.; Sahin, L.; Cizewski, J. A.; Thomas, J. S.; Davinson, T.; Woods, P. J.; Greife, U.; Jewett, C.; Livesay, R. J.; Ma, Z.; Parker, P. D.

2003-04-01

The degree to which the (p,α) and (p,γ) reactions destroy ^18F at temperatures ˜1-4 x 10^8 K is important for understanding the synthesis of nuclei in nova explosions and for using ^18F as a monitor of nova mechanisms in gamma ray astronomy. The reactions are dominated by low-lying proton resonances near the ^18F+p threshold (E_x=6.411 MeV excitation energy in ^19Ne). To gain further information about these resonances, we have used the inverse ^18F(d,p)^19F neutron transfer reaction at the Holifield Radioactive Ion Beam Facility to selectively populate corresponding mirror states in ^19F. Proton angular distributions were measured for states in ^19F in the excitation energy range 0-9 MeV. Results and implications for the ^18F+p reactions and nuclear structure will be presented. ^1Supported by DOE. ^2ORNL is managed by UT-Battelle, LLC, for the USDOE.

Frequency of Cry1F Non-Recessive Resistance Alleles in North Carolina Field Populations of Spodoptera frugiperda (Lepidoptera: Noctuidae).

Science.gov (United States)

Li, Guoping; Reisig, Dominic; Miao, Jin; Gould, Fred; Huang, Fangneng; Feng, Hongqiang

2016-01-01

Fall armyworm, Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae), is a target species of transgenic corn (Zea mays L.) that expresses single and pyramided Bacillus thuringiensis (Bt) toxin. In 2014, S. frugiperda were collected from a light trap in North Carolina, and a total of 212 F1/F2 isofemale lines of S. frugiperda were screened for resistance to Bt and non-Bt corn. All of the 212 isolines were susceptible to corn tissue expressing Cry1A.105 + Cry2Ab, Cry1F + Cry1A.105 + Cry2Ab, and Cry1F + Cry1Ab + Vip3Aa20. Growth rate bioassays were performed to isolate non-recessive Bt resistance alleles. Seven individuals out of the 212 isofemale lines carried major non-recessive alleles conferring resistance to Cry1F. A pooled colony was created from the seven individuals. This colony was 151.21 times more resistant to Cry1F than a known-susceptible population and was also resistant to Cry1A.105, but was not resistant to Cry2Ab and Vip3Aa20. The results demonstrate that field populations of S. frugiperda collected from North Carolina are generally susceptible to Cry1F, but that some individuals carry resistant alleles. The data generated in this study can be used as baseline data for resistance monitoring.

Design and Realization of Rotating Machinery Conditions Monitoring System Based on Labview

Science.gov (United States)

Fan, Qiyuan

Nonlinear dynamic analysis of rotating machinery system has always been the hot spot of the rotational dynamics research. This article sets up a rotating machinery condition monitoring system to realize the measurement of system dynamic characteristic parameters based on NI(National Instruments) virtual instruments technology. The measurement of vibration signal of rotating machinery system is achieved by using NI company general data acquisition module of NI company. Meanwhile, by analyzing and processing the acquired data using Labview 2012, the dynamic characteristics, such as .the speed of the rotating machinery system, the axis trajectory, spectrum parameters, are attained. The measurement results show that the rotating machinery condition monitoring system based on Labview is easy to operate, easy to realize the function extension and maintenance, and that it can be used in the industrial engineering projects with rotation characteristics. Labview as the development tools used by virtual instrument function, is very powerful data acquisition software products support is one of the features of it, so using Labview programming and data acquisition is simple and convenient [1].

Testing ZigBee Motes for Monitoring Refrigerated Vegetable Transportation under Real Conditions

Directory of Open Access Journals (Sweden)

Luis Ruiz-Garcia

2010-05-01

Full Text Available Quality control and monitoring of perishable goods during transportation and delivery services is an increasing concern for producers, suppliers, transport decision makers and consumers. The major challenge is to ensure a continuous ‘cold chain’ from producer to consumer in order to guaranty prime condition of goods. In this framework, the suitability of ZigBee protocol for monitoring refrigerated transportation has been proposed by several authors. However, up to date there was not any experimental work performed under real conditions. Thus, the main objective of our experiment was to test wireless sensor motes based in the ZigBee/IEEE 802.15.4 protocol during a real shipment. The experiment was conducted in a refrigerated truck traveling through two countries (Spain and France which means a journey of 1,051 kilometers. The paper illustrates the great potential of this type of motes, providing information about several parameters such as temperature, relative humidity, door openings and truck stops. Psychrometric charts have also been developed for improving the knowledge about water loss and condensation on the product during shipments.

Conditions of integrability of two equations of the type usub(t)=A(u)usub(xx) + F(u, usub(x)). 1

International Nuclear Information System (INIS)

Mikhajlov, A.V.; Shabat, A.B.; AN SSSR, Ufa. Bashkirskij Filial)

1985-01-01

Necessary conditions of the existence of nontrivial conservation laws for systems of nonlinear equations usub(t)=a(u, ν)usub(xx)+b(u, ν)νsub(xx)+f(u, ν, usub(x), νsub(x)); -νsub(t)=c(u, ν)usub(xx)+d(u, ν)νsub(xx)+g(u, ν, usub(x), νsub(x) are found. They are of the form of densities of local conservation laws constructed from the coefficients of the system. They can easily be checked in each concrete case. Modulus of simple invertible substitutions is discussed which makes it possible to bring the system into the canonical form if certain integrability conditions are fulfilled

Analysis list: E2f1 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available E2f1 Blood,Liver + mm9 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/E2f1.1....tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/E2f1.5.tsv http://dbarchive.biosciencedbc.jp/kyus...hu-u/mm9/target/E2f1.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/E2f1.Blood.tsv,http://dbarchive.bioscience...dbc.jp/kyushu-u/mm9/colo/E2f1.Liver.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/mm9/colo/Blood.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Liver.gml ...

An intelligent service matching method for mechanical equipment condition monitoring using the fibre Bragg grating sensor network

Science.gov (United States)

Zhang, Fan; Zhou, Zude; Liu, Quan; Xu, Wenjun

2017-02-01

Due to the advantages of being able to function under harsh environmental conditions and serving as a distributed condition information source in a networked monitoring system, the fibre Bragg grating (FBG) sensor network has attracted considerable attention for equipment online condition monitoring. To provide an overall conditional view of the mechanical equipment operation, a networked service-oriented condition monitoring framework based on FBG sensing is proposed, together with an intelligent matching method for supporting monitoring service management. In the novel framework, three classes of progressive service matching approaches, including service-chain knowledge database service matching, multi-objective constrained service matching and workflow-driven human-interactive service matching, are developed and integrated with an enhanced particle swarm optimisation (PSO) algorithm as well as a workflow-driven mechanism. Moreover, the manufacturing domain ontology, FBG sensor network structure and monitoring object are considered to facilitate the automatic matching of condition monitoring services to overcome the limitations of traditional service processing methods. The experimental results demonstrate that FBG monitoring services can be selected intelligently, and the developed condition monitoring system can be re-built rapidly as new equipment joins the framework. The effectiveness of the service matching method is also verified by implementing a prototype system together with its performance analysis.

Monitoring parameters of technical condition and safety of aircraft using control charts

Directory of Open Access Journals (Sweden)

В.І. Чепіженко

2007-03-01

Full Text Available  The opportunity of control cards use for monitoring of a technical condition parameters and reliability of aviation techniques is considered at its operation on a technical condition.

The Piston Compressor: The Methodology of the Real-Time Condition Monitoring

International Nuclear Information System (INIS)

Naumenko, A P; Kostyukov, V N

2012-01-01

The methodology of a diagnostic signal processing, a function chart of the monitoring system are considered in the article. The methodology of monitoring and diagnosing is based on measurement of indirect processes' parameters (vibroacoustic oscillations) therefore no more than five sensors is established on the cylinder, measurement of direct structural and thermodynamic parameters is envisioned as well. The structure and principle of expert system's functioning of decision-making is given. Algorithm of automatic expert system includes the calculation diagnostic attributes values based on their normative values, formation sets of diagnostic attributes that correspond to individual classes to malfunction, formation of expert system messages. The scheme of a real-time condition monitoring system for piston compressors is considered. The system have consistently-parallel structure of information-measuring equipment, which allows to measure the vibroacoustic signal for condition monitoring of reciprocating compressors and modes of its work. Besides, the system allows to measure parameters of other physical processes, for example, system can measure and use for monitoring and statements of the diagnosis the pressure in decreasing spaces (the indicator diagram), the inlet pressure and flowing pressure of each cylinder, inlet and delivery temperature of gas, valves temperature, position of a rod, leakage through compression packing and others.

Pre- and post-irradiation fading effect for LiF:Mg,Ti and LiF:Mg,Cu,P materials used in routine monitoring

International Nuclear Information System (INIS)

Carinou, E.; Askounis, P.; Dimitropoulou, F.; Kiranos, G.; Kyrgiakou, H.; Nirgianaki, E.; Papadomarkaki, E.; Kamenopoulou, V.

2011-01-01

LiF is a well-known thermoluminescent (TL) material used in individual monitoring, and its fading characteristics have been studied for years. In the present study, the fading characteristics (for a period of 150 d) of various commercial LiF materials with different dopants have been evaluated. The materials used in the study are those used in routine procedures by the Personal Dosimetry Dept. of Greek Atomic Energy Commission and in particular, LiF:Mg,Ti (MTS-N, TL Poland), LiF:Mg,Cu,P (MCP-N, TL Poland), LiF:Mg,Cu,P (MCP-Ns, thin active layer detector, TL Poland) and LiF:Mg,Cu,P (TLD100H, Harshaw). The study showed that there is a sensitivity loss in signal of up to 20 % for the MTS-N material for a 150-d period in the pre-irradiation fading phase. The MCP-N has a stable behaviour in the pre-irradiation fading phase, but this also depends on the readout system. As far as the post-irradiation fading effect is concerned, a decrease of up to 20 % for the MTS-N material is observed for the same time period. On the other hand, the LiF:Mg,Cu,P material presents a stable behaviour within ±5 %. These results show that the fading effect is different for each material and should be taken into account when estimating doses from dosemeters that are in use for >2 months. (authors)

Geographical and Temporal Variability in Susceptibility to Cry1F Toxin From Bacillus thuringiensis in Spodoptera frugiperda (Lepidoptera: Noctuidae) Populations in Brazil.

Science.gov (United States)

Farias, Juliano R; Horikoshi, Renato J; Santos, Antonio C; Omoto, Celso

2014-12-01

The genetically modified maize TC1507 event with the cry1F gene (Cry1F maize) has been used to control Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) in Brazil since the 2009-2010 cropping season. As part of the insect resistance management program, we conducted studies to determine the baseline susceptibility to Cry1F before the widespread planting of Cry1F maize. Subsequently, we evaluated the geographical and temporal variability of susceptibility to this toxin in populations of S. frugiperda collected from major maize-growing regions in Brazil. The baseline susceptibility to Cry1F was determined using a diet-overlay bioassay for a susceptible reference population and four field populations of S. frugiperda. We then monitored the susceptibility to Cry1F in 43 populations of S. frugiperda sampled in nine States of Brazil between 2011 and 2013. In the baseline study, the MIC50 (the concentration that inhibits molting to second instars in 50% of individuals) ranged from 3.59 to 72.47 ng Cry1F toxin per centimeter square. Based on the upper limit of the MIC99 value of the joint analysis from the baseline susceptibility data, the concentrations of 200 and 2,000 ng of Cry1F toxin per centimeter square were defined as diagnostic concentrations for potentially resistant individuals, and these were used to monitor the susceptibility of S. frugiperda to Cry1F. Survival at 2,000 ng Cry1F toxin per centimeter square increased significantly throughout the cropping seasons in S. frugiperda populations from São Paulo, Santa Catarina, Rio Grande do Sul, Bahia, Mato Grosso, Goiás, Mato Grosso do Sul, and Paraná. The highest survival (>50%) was reached in populations collected from Bahia, Mato Grosso, Goiás, Mato Grosso do Sul, and Paraná during the 2012-2013 cropping season. Therefore, a significant decrease in susceptibility to Cry1F was detected in S. frugiperda throughout cropping seasons, especially in regions with intensive maize production in Brazil

The D1 parameter for the equatorial F1 region

International Nuclear Information System (INIS)

Adeniyi, J.O.; Radicella, S.M.

2002-01-01

This work is a contribution to the effort at improving the representation of the F1 equatorial ionospheric region in the International Reference Ionosphere (IRI) model. The D1 parameter has been proposed for describing the F1 layer. We have therefore produced a maiden table of D1 parameter for an equatorial station. Diurnal and seasonal effects were considered. (author)

Condition monitoring and signature analysis techniques as applied to Madras Atomic Power Station (MAPS) [Paper No.: VIA - 1

International Nuclear Information System (INIS)

Rangarajan, V.; Suryanarayana, L.

1981-01-01

The technique of vibration signature analysis for identifying the machine troubles in their early stages is explained. The advantage is that a timely corrective action can be planned to avoid breakdowns and unplanned shutdowns. At the Madras Atomic Power Station (MAPS), this technique is applied to regularly monitor vibrations of equipment and thus is serving as a tool for doing corrective maintenance of equipment. Case studies of application of this technique to main boiler feed pumps, moderation pump motors, centrifugal chiller, ventilation system fans, thermal shield ventilation fans, filtered water pumps, emergency process sea water pumps, and antifriction bearings of MAPS are presented. Condition monitoring during commissioning and subsequent operation could indicate defects. Corrective actions which were taken are described. (M.G.B.)

Wind Turbine Gearbox Condition Monitoring with AAKR and Moving Window Statistic Methods

Directory of Open Access Journals (Sweden)

Peng Guo

2011-11-01

Full Text Available Condition Monitoring (CM of wind turbines can greatly reduce the maintenance costs for wind farms, especially for offshore wind farms. A new condition monitoring method for a wind turbine gearbox using temperature trend analysis is proposed. Autoassociative Kernel Regression (AAKR is used to construct the normal behavior model of the gearbox temperature. With a proper construction of the memory matrix, the AAKR model can cover the normal working space for the gearbox. When the gearbox has an incipient failure, the residuals between AAKR model estimates and the measurement temperature will become significant. A moving window statistical method is used to detect the changes of the residual mean value and standard deviation in a timely manner. When one of these parameters exceeds predefined thresholds, an incipient failure is flagged. In order to simulate the gearbox fault, manual temperature drift is added to the initial Supervisory Control and Data Acquisitions (SCADA data. Analysis of simulated gearbox failures shows that the new condition monitoring method is effective.

Macroscopic quantum interference in the conventional and coherent quantum 1/F effect with negative quantum entropy states

International Nuclear Information System (INIS)

Handel, P.H.

1998-01-01

The author's recent application of the new Quantum Information Theory Approach (QIT) to Infra Quantum Physics (IQP) explains for the first time the apparent lack of unitarity caused by the entropy increase in the Quantum 1/f Effect (Q1/fE). This allows for a better understanding of the quantum 1/f effect in this paper, showing no resultant entropy increase and therefore no violation of unitarity. This new interpretation involves the concept of von Neumann Quantum Entropy, including the new negative conditional entropy concept for quantum entangled states introduced by QIT. The Q1/fE was applied to many high-tech systems, in particular to ultra small electronic devices. The present paper explains how the additional entropy implied by the Q1/fE arises in spite of the entropy-conserving evolution of the system. On this basis, a general derivation of the conventional and coherent quantum 1/f effect is given. (author)

A Condition Based Maintenance Approach to Forecasting B-1 Aircraft Parts

Science.gov (United States)

2017-03-23

Air Force Institute of Technology AFIT Scholar Theses and Dissertations 3-23-2017 A Condition Based Maintenance Approach to Forecasting B-1 Aircraft...component’s life history where reliability forecasts could be stipulated based on a component’s current condition . One of the major issues their report noted...Engine Condition Monitoring System Specification. Contract Number DOT-CG-80513-A. Grand Prairie, TX. Air Force Materiel Command. (2011) Requirements For

(18)F-alfatide II and (18)F-FDG dual-tracer dynamic PET for parametric, early prediction of tumor response to therapy.

Science.gov (United States)

Guo, Jinxia; Guo, Ning; Lang, Lixin; Kiesewetter, Dale O; Xie, Qingguo; Li, Quanzheng; Eden, Henry S; Niu, Gang; Chen, Xiaoyuan

2014-01-01

A single dynamic PET acquisition using multiple tracers administered closely in time could provide valuable complementary information about a tumor's status under quasiconstant conditions. This study aimed to investigate the utility of dual-tracer dynamic PET imaging with (18)F-alfatide II ((18)F-AlF-NOTA-E[PEG4-c(RGDfk)]2) and (18)F-FDG for parametric monitoring of tumor responses to therapy. We administered doxorubicin to one group of athymic nude mice with U87MG tumors and paclitaxel protein-bound particles to another group of mice with MDA-MB-435 tumors. To monitor therapeutic responses, we performed dual-tracer dynamic imaging, in sessions that lasted 90 min, starting with injection via the tail vein catheters with (18)F-alfatide II, followed 40 min later by (18)F-FDG. To achieve signal separation of the 2 tracers, we fit a 3-compartment reversible model to the time-activity curve of (18)F-alfatide II for the 40 min before (18)F-FDG injection and then extrapolated to 90 min. The (18)F-FDG tumor time-activity curve was isolated from the 90-min dual-tracer tumor time-activity curve by subtracting the fitted (18)F-alfatide II tumor time-activity curve. With separated tumor time-activity curves, the (18)F-alfatide II binding potential (Bp = k3/k4) and volume of distribution (VD) and (18)F-FDG influx rate ((K1 × k3)/(k2 + k3)) based on the Patlak method were calculated to validate the signal recovery in a comparison with 60-min single-tracer imaging and to monitor therapeutic response. The transport and binding rate parameters K1-k3 of (18)F-alfatide II, calculated from the first 40 min of the dual-tracer dynamic scan, as well as Bp and VD correlated well with the parameters from the 60-min single-tracer scan (R(2) > 0.95). Compared with the results of single-tracer PET imaging, (18)F-FDG tumor uptake and influx were recovered well from dual-tracer imaging. On doxorubicin treatment, whereas no significant changes in static tracer uptake values of (18)F-alfatide II

Stereospecific hydroxylation of indan by Escherichia coli containing the cloned toluene dioxygenase genes from Pseudomonas putida F1.

Science.gov (United States)

Brand, J M; Cruden, D L; Zylstra, G J; Gibson, D T

1992-01-01

Escherichia coli JM109(pDTG601), containing the todC1C2BA genes encoding toluene dioxygenase from Pseudomonas putida F1, oxidizes indan to (-)-(1R)-indanol (83% R) and trans-1,3-indandiol. Under similar conditions, P. putida F39/D oxidizes indan to (-)-(1R)-indanol (96% R), 1-indanone, and trans-1,3-indandiol. The differences in the enantiomeric composition of the 1-indanols formed by the two organisms are due to the presence of a 1-indanol dehydrogenase in P. putida F39/D that preferentially oxidizes (+)-(1S)-indanol. PMID:1444374

Equatorially/globally conditioned meteorological analysis of heaviest monsoon rains over India during 23-28 July 2005

Science.gov (United States)

Ranade, Ashwini; Singh, Nityanand

2018-06-01

The heaviest monsoon rainstorm of the period 1951-2007 over India occurred during 23-28 July 2005, mostly the peninsula received rainfall, and each day the rainwater over the country was 40.0 bcm (billion cubic meter) or more, highest 98.4 bcm fell on 25 July 2005. Present premise of monsoon genesis is that it evolves in association with spreading and intensification of equatorial atmospheric condition over Afro-Eurasian landmass and adjoining Indian and Pacific Oceans during boreal summer. Robust natural criteria have been applied to demarcate monsoon and other global weather regimes (GWRs) at standard levels (1000‒100 hPa). Global atmospheric (1000‒100 hPa) thermal condition and monsoon and general circulations during 23-28 July 2005 have been compared with normal features of respective parameters. Over tropics-subtropics (45°S-45°N), troposphere (1000‒250 hPa) was warmer-thicker and pressure lower than normal and mixed conditions of positive/negative departures in temperature, height/thickness and pressure over northern and southern mid-high latitudes. Noticeable changes in 3D monsoon structure were: horizontally spread and eastward-southward shifted over western North Pacific and stretched further southeastward across equatorial Pacific; intense warm-low lower tropospheric confluence-convergence across Asia-Pacific with vertical depth extending beyond 400 hPa; and intense warm-high upper tropospheric anticyclonic circulation zonally stretched and divided into three interconnected cells. Outflows from anticyclonic cells over Tibetan plateau and western North Pacific were mostly directed westward/southwestward/southward. Troposphere was warmer-thicker and pressure higher over eastern part of both subpolars-polars and cooler-thinner and pressure lower over western part. During the period, a deep cyclonic circulation moved from Bay of Bengal through central India while near-stationary atmospheric condition prevailed across the globe.

Coal Mine Accidents in Bangladesh: Its Causes and Remedial Measures

Directory of Open Access Journals (Sweden)

MD. MINHAJ UDDIN MONIR

2012-12-01

C, water flow 600 m3/hr and humidity 100%. Due to roof-fall, toxic gas and very high temperature and humidity in the face 1105 and 1108, some miners were highly injured and died. Therefore, taking necessary safety and risk measures during development of face and roadway in BCM, production will be sustained by controlling roof-fall. Strata pressure of every faces is monitor regularly through electromagnetic emission detector as well as changing sufficient ventilation system, accidents of BCM could be controlled. Adding earth filling materials (e.g. sand, silt etc. in to the vacuum goaf area, air blast accident should be reduced and surface subsidence would also be controlled. Considering all the problems of 1st slice and initiating extra caution for face development accident in BCM may reduce in 2nd slice and overall production may be increased significantly.

Synthesis and preliminary evaluation of 9-(4-[{sup 18}F]fluoro-3-hydroxymethylbutyl) guanine ([{sup 18}F]FHBG) in HSV1-tk gene transduced hepatoma cell

Energy Technology Data Exchange (ETDEWEB)

Moon, Byung Seok; Lee, Tae Sup [Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Lee, Myoung Keun [Yonsei University, Wonju (Korea, Republic of)] (and others)

2006-08-15

The HSV1-tk reporter gene system is the most widely used system because of its advantage that direct monitoring is possible without the introduction of a separate reporter gene in case of HSV1-tk suicide gene therapy. In this study, we investigate the usefulness of the reporter probe (substrate), 9-(4-[{sup 18}F]fluoro-3-hydroxymethylbutyl) guanine ([{sup 18}F]FHBG) for non-invasive reporter gene imaging using PET in HSV1-tk expressing hepatoma model. Radiolabeled FHBG was prepared in 8 steps from a commercially available triester. The labeling reaction was carried out by NCA nucleophilic substitution with K[{sup 18}F]/K2.2.2. in acetonitrile using N2-monomethoxytrityl-9-[4-(tosly)-3-monomethoxytritylmethylbutl] guanine as a precursor, followed by deprotection with 1 N HCI. Preliminary biological properties of the probe were evaluated with MCA cells and MCA-tk cells transduced with HSV1-tk reporter gene. In vitro uptake and release-out studies of [{sup 18}F]FHBG were performed, and was analyzed correlation between [{sup 18}F]FHBG uptake ratio according to increasing numeric count of MCA-tk cells and degree of gene expression. MicroPET scan image was obtained with MCA and MCA-tk tumor beating Balb/c-nude mouse model. [{sup 18}F]FHBG was purified by reverse phase semi-HPLC system and collected at around 16-18 min. Radiochemical yield was about 20-25% (corrected for decay), radiochemical purity was > 95% and specific activity was around > 55.5 GBq/ {mu} mol. Specific accumulation of [{sup 18}F]FHBG was observed in HSV1-tk gene transduced MCA-tk cells but not MCA cells, and consecutive 1 hour release-out results showed more than 86% of uptaked [{sup 18}F]FHBG was retained inside of cells. The uptake of [{sup 18}F]FHBG was showed a highly significant linear correlation (R{sup 2} = 0.995) with increasing percentage of MCA-tk numeric cell count. In microPET scan images, remarkable difference of accumulation was observed for the two type of tumors. [{sup 18}F]FHBG appears

Abnormal Condition Monitoring of Workpieces Based on RFID for Wisdom Manufacturing Workshops

Directory of Open Access Journals (Sweden)

Cunji Zhang

2015-12-01

Full Text Available Radio Frequency Identification (RFID technology has been widely used in many fields. However, previous studies have mainly focused on product life cycle tracking, and there are few studies on real-time status monitoring of workpieces in manufacturing workshops. In this paper, a wisdom manufacturing model is introduced, a sensing-aware environment for a wisdom manufacturing workshop is constructed, and RFID event models are defined. A synthetic data cleaning method is applied to clean the raw RFID data. The Complex Event Processing (CEP technology is adopted to monitor abnormal conditions of workpieces in real time. The RFID data cleaning method and data mining technology are examined by simulation and physical experiments. The results show that the synthetic data cleaning method preprocesses data well. The CEP based on the Rifidi® Edge Server technology completed abnormal condition monitoring of workpieces in real time. This paper reveals the importance of RFID spatial and temporal data analysis in real-time status monitoring of workpieces in wisdom manufacturing workshops.

Abnormal Condition Monitoring of Workpieces Based on RFID for Wisdom Manufacturing Workshops

Science.gov (United States)

Zhang, Cunji; Yao, Xifan; Zhang, Jianming

2015-01-01

Radio Frequency Identification (RFID) technology has been widely used in many fields. However, previous studies have mainly focused on product life cycle tracking, and there are few studies on real-time status monitoring of workpieces in manufacturing workshops. In this paper, a wisdom manufacturing model is introduced, a sensing-aware environment for a wisdom manufacturing workshop is constructed, and RFID event models are defined. A synthetic data cleaning method is applied to clean the raw RFID data. The Complex Event Processing (CEP) technology is adopted to monitor abnormal conditions of workpieces in real time. The RFID data cleaning method and data mining technology are examined by simulation and physical experiments. The results show that the synthetic data cleaning method preprocesses data well. The CEP based on the Rifidi® Edge Server technology completed abnormal condition monitoring of workpieces in real time. This paper reveals the importance of RFID spatial and temporal data analysis in real-time status monitoring of workpieces in wisdom manufacturing workshops. PMID:26633418

General mechanism for the 1 /f noise

Science.gov (United States)

Yadav, Avinash Chand; Ramaswamy, Ramakrishna; Dhar, Deepak

2017-08-01

We consider the response of a memoryless nonlinear device that acts instantaneously, converting an input signal ξ (t ) into an output η (t ) at the same time t . For input Gaussian noise with power-spectrum 1 /fα , the nonlinearity can modify the spectral index of the output to give a spectrum that varies as 1 /fα ' with α'≠α . We show that the value of α' depends on the nonlinear transformation and can be tuned continuously. This provides a general mechanism for the ubiquitous 1 /f noise found in nature.

Synthesis of 2'-deoxy-2'-[{sup 18}F]-fluoro-5-iodo-1-{beta}-D-arabinofuranosyluracil ([{sup 18}F]-FIAU) and micro-PET imaging of suicide gene expression in tumor-bearing nude mice

Energy Technology Data Exchange (ETDEWEB)

Alauddin, M.M.; Shahinian, A.; Park, R.; Tohme, M.; Fissekis, J.D.; Conti, P.S. [Univ. of Southern California, Los Angeles, CA (United States). PET Imaging Science Center

2004-07-01

Herpes simplex virus type-1 thymidine kinase (HSV1-tk) is being used as a suicide gene for gene therapy of cancer. An in vivo method to assess the HSV1-tk enzyme activity after gene transfer is desirable to monitor gene expression as an indicator of gene delivery. Imaging of the HSV1-tk reporter gene along with various reporter probes is of current interest. We originally developed [{sup 18}F]-FHPG and [{sup 18}F]-FHBG for PET imaging of HSV1-tk gene expression and demonstrated that [{sup 18}F]-FHBG is more useful than [{sup 18}F]-FHPG for this purpose. [{sup 124}I]-FIAU has been shown to be a potential PET imaging agent for HSV1-tk gene expression, and is superior to [{sup 18}F]-FHPG and [{sup 18}F]-FHBG. We also demonstrated that radiolabeled FMAU can be used as a marker for HSV-tk gene expression, and is superior to [{sup 18}F]-FHPG and [{sup 18}F]-FHBG. Earlier we reported a synthesis for 2'-deoxy-2'-[{sup 18}F]fluoro-5-methyl-1-{beta}-D-arabinofuranosyluracil ([{sup 18}F]-FMAU) and some other 5-substituted nucleosides. We have synthesized now [{sup 18}F]-FIAU, used the tracer for micro-PET imaging of suicide gene expression in tumor-bearing nude mice, and compared the results with earlier studies using [{sup 14}C]-FMAU. (orig.)

Alimentary tract absorption (f1 values) for radionuclides in local and regional fallout from nuclear tests.

Science.gov (United States)

Ibrahim, Shawki A; Simon, Steven L; Bouville, André; Melo, Dunstana; Beck, Harold L

2010-08-01

This paper presents gastrointestinal absorption fractions (f1 values) for estimating internal doses from local and regional fallout radionuclides due to nuclear tests. The choice of f1 values are based on specific circumstances of weapons test conditions and a review of reported f1 values for elements in different physical and chemical states. Special attention is given to fallout from nuclear tests conducted at the Marshall Islands. We make a distinction between the f1 values for intakes of radioactive materials immediately after deposition (acute intakes) and intakes that occur in the course of months and years after deposition, following incorporation into terrestrial and aquatic foodstuffs (chronic intakes). Multiple f1 values for different circumstances where persons are exposed to radioactive fallout (e.g., local vs. regional fallout and coral vs. continental tests) are presented when supportive information is available. In some cases, our selected f1 values are similar to those adopted by the International Commission on Radiological Protection (ICRP) (e.g., iodine and most actinides). However, f1 values for cesium and strontium derived from urine bioassay data of the Marshallese population are notably lower than the generic f1 values recommended by ICRP, particularly for acute intakes from local fallout (0.4 and 0.05 for Cs and Sr, respectively). The f1 values presented here form the first complete set of values relevant to realistic dose assessments for exposure to local or regional radioactive fallout.

Monitoring the Microcirculation in Critical Conditions: Possibilities and Limitations

Directory of Open Access Journals (Sweden)

T. O. Tokmakova

2012-01-01

Full Text Available The paper provides an analytical review of the references on the role of microcirculatory disorders in the development of critical conditions, the significance of circulatory monitoring, specifically, to make a presumptive prognosis of multiple organ dysfunction. It defines main directions in the diagnosis and correction of microcirculatory disorders as direct (infusion therapy and indirect (influence on the components of a systemic inflammatory response, by extending to microcirculatory correction microcirculatory exposures. Key words: critical conditions, multiple organ dysfunction, procedures to evaluate and correct microcirculation.

Interim-status groundwater monitoring plan for the 216-B-63 trench

Energy Technology Data Exchange (ETDEWEB)

Sweeney, M.D.

1995-02-09

This document outlines the groundwater monitoring plan, under RCRA regulations in 40 CFR 265 Subpart F and WAC173-300-400, for the 216-B-63 Trench. This interim status facility is being sampled under detection monitoring criteria and this plan provides current program conditions and requirements.

Reactor operation monitor

International Nuclear Information System (INIS)

Sakagami, Masaharu.

1982-01-01

Purpose: To improve the working performance of a reactor by extending the range for the power conditioning due to the control rod operation and flow rate control. Constitution: The results of calculations for the power distribution and the burn-up degree distribution of the reactor core from a reactor performance computer that processes each of measuring signals in a nuclear power plant are used as the inputs for a computing device of the fuel rod power hysteresis to form the power hysteresis for each of the fuel rods up to the present time. The data are used as the inputs for the computing device of the fuel rod performance index, and the fuel rod performance index representing the critical values for the stresses in the fuel rod cladding tubes and the critical values for the duration of the stresses determined from the power hysteresis and the burn-up degree of the fuel rod are calculated for each of the fuel rods. Accordingly, the power conditioning can be carried out upon power-up in the reactor while monitoring the fuel rod performance index f(t) for each of the fuel assemblies, whereby the range for the power conditioning due to the control rod operation and the flow rate control can be extended relative to fuel assemblies in which f(t) is smaller than 1. (Yoshino, Y.)

Non-invasive glucagon-like peptide-1 receptor imaging in pancreas with {sup 18}F-Al labeled Cys{sup 39}-exendin-4

Energy Technology Data Exchange (ETDEWEB)

Mi, Baoming [Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006 (China); Department of Nuclear Medicine, Affiliated Hospital of Jiangnan University (Wuxi 4th People' s Hospital), Wuxi, Jiangsu, 214062 (China); Xu, Yuping [Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, 214063 (China); Nanjing Medical University, Nanjing, Jiangsu, 210029 (China); Pan, Donghui; Wang, Lizhen; Yang, Runlin [Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, 214063 (China); Yu, Chunjing; Wan, Weixing [Department of Nuclear Medicine, Affiliated Hospital of Jiangnan University (Wuxi 4th People' s Hospital), Wuxi, Jiangsu, 214062 (China); Wu, Yiwei, E-mail: wuyiwei3988@gmail.com [Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006 (China); Yang, Min, E-mail: ymzfk@yahoo.com.hk [Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu, 214063 (China); Nanjing Medical University, Nanjing, Jiangsu, 210029 (China)

2016-02-26

Purpose: Glucagon-like peptide-1 receptor (GLP-1R) is abundantly expressed on beta cells and may be an ideal target for the pancreas imaging. Monitoring the GLP-1R of pancreas could be benefit for understanding the pathophysiology of diabetes. In the present study, {sup 18}F-Al labeled exendin-4 analog, {sup 18}F-Al-NOTA-MAL-Cys{sup 39}-exendin-4, was evaluated for PET imaging GLP-1R in the pancreas. Methods: The targeting of {sup 18}F-Al labeled exendin-4 analog was examined in healthy and streptozotocin induced diabetic rats. Rats were injected with {sup 18}F-Al-NOTA-MAL-Cys{sup 39}-exendin-4 and microPET imaging was performed at 1 h postinjection, followed by ex vivo biodistribution. GLP-1R expression in pancreas was determined through post mortern examinations. Results: The pancreas of healthy rats was readily visualized after administration of {sup 18}F-Al-NOTA-MAL-Cys{sup 39}-exendin-4, whereas the pancreas of diabetic rats, as well as those from rats co-injected with excess of unlabeled peptides, was barely visible by microPET. At 60 min postinjection, the pancreatic uptakes were 1.02 ± 0.15%ID/g and 0.23 ± 0.05%ID/g in healthy and diabetic rats respectively. Under block, the pancreatic uptakes of non-diabetic rats reduced to 0.21 ± 0.07%ID/g at the same time point. Biodistribution data and IHC staining confirmed the findings of the microPET imaging. Conclusion: The favorable preclinical data indicated that {sup 18}F-Al-NOTA-MAL-Cys{sup 39}-exendin-4may be suitable for non-invasive monitoring functional pancreatic beta cells.

Bioimpedance Spectroscopy for Assessment of Volume Status in Patients before and after General Anaesthesia

Science.gov (United States)

Ernstbrunner, Matthäus; Kostner, Lisa; Kimberger, Oliver; Wabel, Peter; Säemann, Marcus; Markstaller, Klaus; Fleischmann, Edith; Kabon, Barbara; Hecking, Manfred

2014-01-01

Background Technically assisted assessment of volume status before surgery may be useful to direct intraoperative fluid administration. We therefore tested a recently developed whole-body bioimpedance spectroscopy device to determine pre- to postoperative fluid distribution. Methods Using a three-compartment physiologic tissue model, the body composition monitor (BCM, Fresenius Medical Care, Germany) measures total body fluid volume, extracellular volume, intracellular volume and fluid overload as surplus or deficit of ‘normal’ extracellular volume. BCM-measurements were performed before and after standardized general anaesthesia for gynaecological procedures (laparotomies, laparoscopies and vaginal surgeries). BCM results were blinded to the attending anaesthesiologist and data analysed using the 2-sided, paired Student’s t-test and multiple linear regression. Results In 71 females aged 45±15 years with body weight 67±13 kg and duration of anaesthesia 154±68 min, pre- to postoperative fluid overload increased from −0.7±1.1 L to 0.1±1.0 L, corresponding to −5.1±7.5% and 0.8±6.7% of normal extracellular volume, respectively (both p<0.001), after patients had received 1.9±0.9 L intravenous crystalloid fluid. Perioperative urinary excretion was 0.4±0.3 L. The increase in extracellular volume was paralleled by an increase in total body fluid volume, while intracellular volume increased only slightly and without reaching statistical significance (p = 0.15). Net perioperative fluid balance (administered fluid volume minus urinary excretion) was significantly associated with change in extracellular volume (r2 = 0.65), but was not associated with change in intracellular volume (r2 = 0.01). Conclusions Routine intraoperative fluid administration results in a significant, and clinically meaningful increase in the extracellular compartment. BCM-measurements yielded plausible results and may become useful to guide intraoperative fluid therapy in

Role of nesprin-1 in nuclear deformation in endothelial cells under static and uniaxial stretching conditions

International Nuclear Information System (INIS)

Anno, Toshiro; Sakamoto, Naoya; Sato, Masaaki

2012-01-01

Highlights: ► Nesprin-1 knockdown decreases widths of nuclei in ECs under static condition. ► Nuclear strain caused by stretching is increased by nesprin-1 knockdown in ECs. ► We model mechanical interactions of F-actin with the nucleus in stretched cells. ► F-actin bound to nesprin-1 may cause sustainable force transmission to the nucleus. -- Abstract: The linker of nucleus and cytoskeleton (LINC) complex, including nesprin-1, has been suggested to be crucial for many biological processes. Previous studies have shown that mutations in nesprin-1 cause abnormal cellular functions and diseases, possibly because of insufficient force transmission to the nucleus through actin filaments (F-actin) bound to nesprin-1. However, little is known regarding the mechanical interaction between the nucleus and F-actin through nesprin-1. In this study, we examined nuclear deformation behavior in nesprin-1 knocked-down endothelial cells (ECs) subjected to uniaxial stretching by evaluating nuclear strain from lateral cross-sectional images. The widths of nuclei in nesprin-1 knocked-down ECs were smaller than those in wild-type cells. In addition, nuclear strain in nesprin-1 knocked-down cells, which is considered to be compressed by the actin cortical layer, increased compared with that in wild-type cells under stretching condition. These results indicate that nesprin-1 knockdown releases the nucleus from the tension of F-actin bound to the nucleus, thereby increasing allowance for deformation before stretching, and that F-actin bound to the nucleus through nesprin-1 causes sustainable force transmission to the nucleus.

New oil condition monitoring system, Wearsens® enables continuous, online detection of critical operating conditions and wear damage

Directory of Open Access Journals (Sweden)

Manfred Mauntz

2015-12-01

Full Text Available A new oil sensor system is presented for the continuous, online measurement of the wear in turbines, industrial gears, generators, hydraulic systems and transformers. Detection of change is much earlier than existing technologies such as particle counting, vibration measurement or recording temperature. Thus targeted, corrective procedures and/or maintenance can be carried out before actual damage occurs. Efficient machine utilization, accurately timed preventive maintenance, increased service life and a reduction of downtime can all be achieved. The presented sensor system effectively controls the proper operation conditions of bearings and cogwheels in gears. The online diagnostics system measures components of the specific complex impedance of oils. For instance, metal abrasion due to wear debris, broken oil molecules, forming acids or oil soaps, result in an increase of the electrical conductivity, which directly correlates with the degree of contamination of the oil. For additivated lubricants, the stage of degradation of the additives can also be derived from changes in the dielectric constant. The determination of impurities or reduction in the quality of the oil and the quasi continuous evaluation of wear and chemical aging follow the holistic approach of a real-time monitoring of an alteration in the condition of the oil-machine system. Once the oil condition monitoring sensors are installed on the wind turbine, industrial gearbox and test stands, the measuring data can be displayed and evaluated elsewhere. The signals are transmitted to a web-based condition monitoring system via LAN, WLAN or serial interfaces of the sensor unit. Monitoring of the damage mechanisms during proper operation below the tolerance limits of the components enables specific preventive maintenance independent of rigid inspection intervals.

Wind Turbine Gearbox Condition Monitoring Round Robin Study - Vibration Analysis

Energy Technology Data Exchange (ETDEWEB)

Sheng, S.

2012-07-01

The Gearbox Reliability Collaborative (GRC) at the National Wind Technology Center (NWTC) tested two identical gearboxes. One was tested on the NWTCs 2.5 MW dynamometer and the other was field tested in a turbine in a nearby wind plant. In the field, the test gearbox experienced two oil loss events that resulted in damage to its internal bearings and gears. Since the damage was not severe, the test gearbox was removed from the field and retested in the NWTCs dynamometer before it was disassembled. During the dynamometer retest, some vibration data along with testing condition information were collected. These data enabled NREL to launch a Wind Turbine Gearbox Condition Monitoring Round Robin project, as described in this report. The main objective of this project was to evaluate different vibration analysis algorithms used in wind turbine condition monitoring (CM) and find out whether the typical practices are effective. With involvement of both academic researchers and industrial partners, the project sets an example on providing cutting edge research results back to industry.

Study of gamma-ray induced variability on F1M1-F3M3 distant tomato hybrids

International Nuclear Information System (INIS)

Siromeatnicov, Iulia; Cotenco, Eugenia; Ciobanu, Renata

2013-01-01

The outcome of the evaluation of the gamma radiation's action, the growth and development tomato plant has shown that the coefficient of variation of plant height character is on the rise with increasing doses of gamma radiation. The hybrid combination F 1 M 1 (L.hpriz.1998) irradiated with dose 150 Gy variant presented superior value a towards scrutiny for plant height of the characters, number of flowers and fruits per bunch, number of fruits per plant and fruit mass of. The character F 2 M 2 generation plant height registered diminished value compared to F 1 M 1 generation. The highest value was recorded at the hybrid combination F 2 M 2 L.hpriz.1998 200 Gy treated dose. The evaluation research has highlighted that at the doses 100 Gy, 150 Gy, 200 Gy, have confirmed an increase in characters of reproductive system: the number of flowers and fruits per bunch, number of fruits per plant, fruit mass and reduction of the characters waist and height of placing of the first inflorescences plant. Similar aspects with some differences as low as hybrid combination Lhpi1998 in relation to the radiation doses used under study were confirmed in the case F 3 M 3 . (authors)

Monitoring of the Formation and Development Process for Infection and Inflammation Using F-18 FDG, PET/CT

Directory of Open Access Journals (Sweden)

Türkan Ertay

2015-02-01

Full Text Available Objective: Many radiopharmaceuticals have been evaluated extensively in both preclinical and clinical studies as potential diagnostic agents to identify the sites of infection. There is a definite role of FDG-PET in diagnosis, extent of assessing the disease, evaluation of treatment response and disease activity in patients with infections and inflammation. The aim of the study, the process of formation and development of infection and inflammation is monitored using (18 F 2’-deoxy-2-fluoroD-glucose (F-18 FDG by Positron Emission Computed Tomography (PET-CT. Methods: In this study, sterile abscess was induced by using turpentine and infected abscess was induced by using Staphylococcus aureus atcc 25923 strain on rats. In the abscess formation on rats, three grups rats were used as sterile, infected and control grups. There were examined male White Wistar Rats, the clinical healthy animals were 150-220 gr body weight. Bacterial strain and rat model for abscess formation for infected abscess formation on rats (n=7, S. aureus 0.5 ml 107 CFU/ml was inoculated in the right arm of the rats as subcutaneous. For sterile abscess formation on rats (n=7 0.2-0.4 ml turpentine (sigma-aldrich was injected into the right arm of the rats as subcutaneous. In control group (n=6, 0.5 ml 0.9% NaCl was injected into the right arm of the rats as subcutaneous. First day imsaging was acquired 24 hours after inoculation of S.aureus and turpentine. 1 mCi 18F-FDG was injected intravenously via the tail vein. Prior to 18F-FDG injection, rats fasted at least 4 hours and well hydrated. Imaging was done using PET-CT (PHILIPS Gemini TF, beginning 1 hour following injection of 18F-FDG IV in the first day and at intervals of 24 hours for five days. First day imaging was performed 1. hour after IV injection of 18F-FDG to obtain optimum imaging time. PET/CT images were visually and semiquantitatively assessed. For semiquantitative analysis of the PET images, a region of interest

Sodium fast reactor power monitoring using {sup 20}F tagging agent

Energy Technology Data Exchange (ETDEWEB)

Coulon, R.; Normand, S. [CEA, LIST, Laboratoire Capteurs et Architectures Electroniques, Centre de Saclay, 91191 Gif sur Yvette Cedex (France); Ban, G. [ENSICAEN, F-14050 Caen (France); Dumarcher, V.; Brau, H. P.; Barbot, L.; Domenech, T.; Kondrasovs, V.; Corre, G.; Frelin, A. M.; Montagu, T.; Dautremer, T.; Barat, E.

2009-07-01

This work deals with the use of gamma spectrometry to monitor the fourth generation sodium fast reactor (SFR) power. Simulation part has shown that power monitoring in short response time and with high accuracy is possible measuring delayed gamma emitters produced in the liquid sodium. An experimental test is under preparation at French SFR Phenix experimental reactor to validate simulation studies. Physical calculations have been done to correlate gamma activity to the released thermal power. Gamma emitter production rate in the reactor core was calculated with technical and nuclear data as sodium velocity, atomic densities, neutron spectra and incident neutron cross-sections of fission reactions, and also sodium activation reactions producing gamma emitters. Then, a thermal hydraulic transfer function was used for taking into account primary sodium flow in our calculations. Gamma spectra were then determined by Monte-Carlo simulations. The experiment will be set during the reactor 'ultimate testing'. The Delayed Neutron Detection (DND) system cell has been chosen as the best available primary sodium sample for gamma power monitoring on Phenix reactor due to short sodium transit time from reactor core to measurement sample and homogenized sampling in the reactor hot pool. The main gamma spectrometer is composed of a coaxial high purity germanium diode (HPGe) coupled with a transistor reset preamplifier. The signal is then processed by a digital signal processing system (called Adonis) which always gives optimum answer even for high count rate and various time activity measurements. For power monitoring problematic, use of a short decay period gamma emitter as the {sup 20}F will allow to obtain a very fast response system without cumulative and flow distortion effects. These works introduce advantages and performances of this new power monitoring system for future SFR. (authors)

The translocator protein radioligand 18F-DPA-714 monitors antitumor effect of erufosine in a rat 9L intracranial glioma model

International Nuclear Information System (INIS)

Awde, Ali R.; Boisgard, Raphael; Theze, Benoit; Dubois, Albertine; Zheng, Jinzi; Winkeler, Alexandra; Dolle, Frederic; Jacobs, Andreas H.; Tavitian, Bertrand

2013-01-01

On the one hand, the translocator protein (TSPO) radioligand N,N-diethyl-2-(2-(4-(2- 18 F-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo[1,5-a] pyrimidin-3-yl)acetamide ( 18 F-DPA-714) has been suggested to serve as an alternative radiotracer to image human glioma, and on the other hand the alkyl-phosphocholine erufosine (ErPC3) has been reported to induce apoptosis in otherwise highly apoptosis resistant glioma cell lines. The induction of apoptosis by ErPC3 requires TSPO, a mitochondrial membrane protein highly expressed in malignant gliomas. In this preclinical study, we monitored the effect of ErPC3 treatment in vivo using 18 F-DPA-714 PET. Methods: In vitro studies investigated the antitumor effect of ErPC3 in 9L rat gliosarcoma cells. In vivo, glioma-bearing rats were imaged with 18 F-DPA-714 for the time of treatment. Results: A significant decrease in 9L cell proliferation and viability and a significant increase in apoptosis and caspase-3 activation were demonstrated on ErPC3 treatment in cell culture. In the rat model, ErPC3 administration resulted in significant changes in 18 F-DPA-714 tumor uptake over the course of the treatment. Immunohistochemistry revealed reduced tumor volume and increased cell death in ErPC3-treated animals accompanied by infiltration of the tumor core by CD11b-positive micro-glia/macrophages and glial fibrillary acidic protein-positive astrocytes. Conclusion: Our findings demonstrate a potent antitumor effect of ErPC3 in vitro, in vivo, and ex vivo. PET imaging of TSPO expression using 18 F-DPA-714 allows effective monitoring and quantification of disease progression and response to ErPC3 therapy in intracranial 9L gliomas. (authors)

Quantitative Impact of Plasma Clearance and Down-regulation on GLP-1 Receptor Molecular Imaging.

Science.gov (United States)

Zhang, Liang; Thurber, Greg M

2016-02-01

Quantitative molecular imaging of beta cell mass (BCM) would enable early detection and treatment monitoring of type 1 diabetes. The glucagon-like peptide-1 (GLP-1) receptor is an attractive target due to its beta cell specificity and cell surface location. We quantitatively investigated the impact of plasma clearance and receptor internalization on targeting efficiency in healthy B6 mice. Four exenatide-based probes were synthesized that varied in molecular weight, binding affinity, and plasma clearance. The GLP-1 receptor internalization rate and in vivo receptor expression were quantified. Receptor internalization (54,000 receptors/cell in vivo) decreased significantly within minutes, reducing the benefit of a slower-clearing agent. The multimers and albumin binding probes had higher kidney and liver uptake, respectively. Slow plasma clearance is beneficial for GLP-1 receptor peptide therapeutics. However, for exendin-based imaging of islets, down-regulation of the GLP-1 receptor and non-specific background uptake result in a higher target-to-background ratio for fast-clearing agents.

Condition Monitoring and Management from Acoustic Emissions

DEFF Research Database (Denmark)

Pontoppidan, Niels Henrik Bohl

2005-01-01

In the following, I will use technical terms without explanation as it gives the freedom to describe the project in a shorter form for those who already know. The thesis is about condition monitoring of large diesel engines from acoustic emission signals. The experiments have been focused...... is the analysis of the angular position changes of the engine related events such as fuel injection and valve openings, caused by operational load changes. With inspiration from speech recognition and voice effects the angular timing changes have been inverted with the event alignment framework. With the event...

Condition monitoring approach for permanent magnet synchronous motor drives based on the INFORM method

OpenAIRE

Arellano-Padilla, J.; Sumner, M.; Gerada, C.

2016-01-01

This paper proposes a monitoring scheme based on saliency tracking to assess the health condition of PMSM drives operating under non stationary conditions. The evaluated scheme is based on the INFORM methodology, which is associated to the accurate sensorless control of PM drives without zero speed limitation. The result is a monitoring scheme that is able to detect faults that would be very difficult to evaluate under nonstationary conditions. A relevant aspect of the proposed scheme is that...

Vibration condition monitoring of planetary gearbox under varying external load

Energy Technology Data Exchange (ETDEWEB)

Bartelmus, W.; Zimroz, R. [Wroclaw University of Technology, Wroclaw (Poland)

2009-01-15

The paper shows that for condition monitoring of planetary gearboxes it is important to identify the external varying load condition. In the paper, systematic consideration has been taken of the influence of many factors on the vibration signals generated by a system in which a planetary gearbox is included. These considerations give the basis for vibration signal interpretation, development of the means of condition monitoring, and for the scenario of the degradation of the planetary gearbox. Real measured vibration signals obtained in the industrial environment are processed. The signals are recorded during normal operation of the diagnosed objects, namely planetary gearboxes, which are a part of the driving system used in a bucket wheel excavator, used in lignite mines. It has been found that the most important factor of the proper planetary gearbox condition is connected with perturbation of arm rotation, where an arm rotation gives rise to a specific vibration signal whose properties are depicted by a short-time Fourier transform (STFT) and Wigner-Ville distribution presented as a time-frequency map. The paper gives evidence that there are two dominant low-frequency causes that influence vibration signal modulation, i.e. the varying load, which comes from the nature of the bucket wheel digging process, and the arm/carrier rotation. These two causes determine the condition of the planetary gearboxes considered.

A design condition for incorporating human judgement into monitoring systems

International Nuclear Information System (INIS)

Tanaka, K.; Klir, G.J.

1999-01-01

In safety monitoring, there exists an uncertainty situation in which the sensor cannot detect whether or not the monitored object is in danger. For the uncertainty zone identified by a non-homogeneous safety monitoring system that utilizes two types of sensors with different thresholds, operators or experts are expected to judge whether the real state is safe or dangerous on the basis of additional information from a detailed inspection or other related sensors output. However, the activities for inspection performed by relevant humans may require additional cost and introduce inspection errors. The present article proposes two types of an automatic monitoring system not involving any human inspection or a human-machine (H-M) cooperative monitoring system with inspection. In order to compare the systems, an approach based on the Dempster-Shafer theory is proposed as uncertainty analysis by this theory (it is simpler than by the traditional Bayesian approach). By comparing their expected losses as a result of failed dangerous failures or failed safe failures as well as the inspection errors, the condition is determined under which H-M cooperative systems incorporating human judgements are more effective than automatic monitoring systems

Verification of the machinery condition monitoring technology by fault simulation tests

International Nuclear Information System (INIS)

Maehara, Takafumi; Watanabe, Yukio; Osaki, Kenji; Higuma, Koji; Nakano, Tomohito

2009-01-01

This paper shows the test items and equipments introduced by Japan Nuclear Energy Safety Organization to establish the monitoring technique for machinery conditions. From the result of vertical pump simulation tests, it was confirmed that fault analysis was impossible by measuring the accelerations on both motor and pump column pipes, however, was possible by measuring of pump shaft vibrations. Because hydraulic whirls by bearing wear had significant influences over bearing misalignments and flow rates, the monitoring trends must be done under the same condition (on bearing alignments and flow rates). We have confirmed that malfunctions of vertical pumps can be diagnosed using measured shaft vibration by ultrasonic sensors from outer surface of pump casing on the floor. (author)

The estimation of hemodynamic signals measured by fNIRS response to cold pressor test

Science.gov (United States)

Ansari, M. A.; Fazliazar, E.

2018-04-01

The estimation of cerebral hemodynamic signals has an important role for monitoring the stage of neurological diseases. Functional Near-Infrared Spectroscopy (fNIRS) can be used for monitoring of brain activities. fNIRS utilizes light in the near-infrared spectrum (650-1000 nm) to study the response of the brain vasculature to the changes in neural activities, called neurovascular coupling, within the cortex when cognitive activation occurs. The neurovascular coupling may be disrupted in the brain pathological condition. Therefore, we can also use fNIRS to diagnosis brain pathological conditions or to monitor the efficacy of related treatments. The Cold pressor test (CPT), followed by immersion of dominant hand or foot in the ice water, can induce cortical activities. The perception of pain induced by CPT can be related to cortical neurovascular coupling. Hence, the variation of cortical hemodynamic signals during CPT can be an indicator for studying neurovascular coupling. Here, we study the effect of pain induced by CPT on the temporal variation of concentration of oxyhemoglobin [HbO2] and deoxyhemoglobin [Hb] in the healthy brains. We use fNIRS data collected on forehead during a CPT from 11 healthy subjects, and the average data are compared with post-stimulus pain rating scores. The results show that the variation of [Hb] and [HbO2] are positively correlated with self-reported scores during the CPT. These results depict that fNIRS can be potentially applied to study the decoupling of neurovascular process in brain pathological conditions.

Evaluation of subcutaneous glucose monitoring systems under routine environmental conditions in patients with type 1 diabetes.

Science.gov (United States)

Aberer, Felix; Hajnsek, Martin; Rumpler, Markus; Zenz, Sabine; Baumann, Petra M; Elsayed, Hesham; Puffing, Adelheid; Treiber, Gerlies; Pieber, Thomas R; Sourij, Harald; Mader, Julia K

2017-07-01

Continuous and flash glucose monitoring (GM) systems have been established in diabetes care. We compared the sensor performance of 3 commercially available GM systems. A total of 12 patients with type 1 diabetes were included in a single-centre, open-label study in which the sensor performance of the Abbott FreeStyle libre (Abbott), Dexcom G4 Platinum (Dexcom) and Medtronic MiniMed 640G (Medtronic) systems over 12 hours was compared during mimicked real-life conditions (meals, exercise, hypo- and hyperglycaemia). Sensor performance was determined by fulfilment of ISO 15197:2013 criteria, calculating mean absolute relative difference (MARD), and was also illustrated using Parkes error grid and Bland-Altman plots. Sensor performance during changes in metabolic variables (lactate, betahydroxybutyrate, glucagon, non-esterified-fatty-acids) was determined by Spearman's rank correlation coefficient testing. The systems fulfilled ISO 15197:2013 criteria by 73.2% (Abbott), 56.1% (Dexcom) and 52.0% (Medtronic). The MARDs ± standard deviation in the entire glycaemic range were 13.2% ± 10.9% (Abbott), 16.8% ± 12.3% (Dexcom) and 21.4% ± 17.6% (Medtronic), respectively. All sensors performed less accurately during hypoglycaemia and best during hyperglycaemia. We did not observe an influence of metabolic variables on sensor performance. © 2017 John Wiley & Sons Ltd.

Condition monitoring of a motor-operated valve using estimated motor torque

International Nuclear Information System (INIS)

Chai, Jangbom; Kang, Shinchul; Park, Sungkeun; Hong, Sungyull; Lim, Chanwoo

2004-01-01

This paper is concerned with the development of data analysis methods to be used in on-line monitoring and diagnosis of Motor-Operated Valves (MOVs) effectively and accurately. The technique to be utilized includes the electrical measurements and signal processing to estimate electric torque of induction motors, which are attached to most of MOV systems. The estimated torque of an induction motor is compared with the directly measured torque using a torque cell in various loading conditions including the degraded voltage conditions to validate the estimating scheme. The accuracy of the estimating scheme is presented. The advantages of the estimated torque signatures are reviewed over the currently used ones such as the current signature and the power signature in several respects: accuracy, sensitivity, resolution and so on. Additionally, the estimated torque methods are suggested as a good way to monitor the conditions of MOVs with higher accuracy. (author)

Sperm Production and Mating Ability Among F1 males of Heliothis Virescens (F.)

International Nuclear Information System (INIS)

Ibrahim, S.M.; Sallam, H.A.

2000-01-01

Adult males of Heliothis Virescens (F.) less than 12 h-old were irradiated with sub sterilizing doses of 50,100 or 125 Gy then crossed with untreated virgin females. The resulted F 1 males 1-and 4-day-old were dissected to determine the production of eupyrene sperm bundles and its accumulation in the duplex region. In another test, an experiment was conducted to determine the ability of F 1 males to mate and transfer sperm to untreated females. The data show that, eupyrene sperm bundles were not found in the duplex of newly emerged males immediately after emergence Number of eupyrene sperm bundles descended to duplex was significantly affected at 125 Gy during the first dark: light cycle of sperm descended. Accumulation of eupyrene sperm bundles of unmated F 1 males was significantly reduced at 100 and 125 Gy. It is apparent that the first mating is the most important, even in the control, and the rate of females that achieved successful mating with F 1 males after the first ejaculate was markedly reduced. This reduction was directly related to the dose level of irradiation. The proportion of mated females without and sperm, with apyrene sperms only or those with reduced amount of eupyrene sperms was generally increased as the dose applied to P 1 increased

EBP1 is a novel E2F target gene regulated by transforming growth factor-β.

Directory of Open Access Journals (Sweden)

David Judah

2010-11-01

Full Text Available Regulation of gene expression requires transcription factor binding to specific DNA elements, and a large body of work has focused on the identification of such sequences. However, it is becoming increasingly clear that eukaryotic transcription factors can exhibit widespread, nonfunctional binding to genomic DNA sites. Conversely, some of these proteins, such as E2F, can also modulate gene expression by binding to non-consensus elements. E2F comprises a family of transcription factors that play key roles in a wide variety of cellular functions, including survival, differentiation, activation during tissue regeneration, metabolism, and proliferation. E2F factors bind to the Erb3-binding protein 1 (EBP1 promoter in live cells. We now show that E2F binding to the EBP1 promoter occurs through two tandem DNA elements that do not conform to typical consensus E2F motifs. Exogenously expressed E2F1 activates EBP1 reporters lacking one, but not both sites, suggesting a degree of redundancy under certain conditions. E2F1 increases the levels of endogenous EBP1 mRNA in breast carcinoma and other transformed cell lines. In contrast, in non-transformed primary epidermal keratinocytes, E2F, together with the retinoblastoma family of proteins, appears to be involved in decreasing EBP1 mRNA abundance in response to growth inhibition by transforming growth factor-β1. Thus, E2F is likely a central coordinator of multiple responses that culminate in regulation of EBP1 gene expression, and which may vary depending on cell type and context.

EBP1 is a novel E2F target gene regulated by transforming growth factor-β.

Science.gov (United States)

Judah, David; Chang, Wing Y; Dagnino, Lina

2010-11-10

Regulation of gene expression requires transcription factor binding to specific DNA elements, and a large body of work has focused on the identification of such sequences. However, it is becoming increasingly clear that eukaryotic transcription factors can exhibit widespread, nonfunctional binding to genomic DNA sites. Conversely, some of these proteins, such as E2F, can also modulate gene expression by binding to non-consensus elements. E2F comprises a family of transcription factors that play key roles in a wide variety of cellular functions, including survival, differentiation, activation during tissue regeneration, metabolism, and proliferation. E2F factors bind to the Erb3-binding protein 1 (EBP1) promoter in live cells. We now show that E2F binding to the EBP1 promoter occurs through two tandem DNA elements that do not conform to typical consensus E2F motifs. Exogenously expressed E2F1 activates EBP1 reporters lacking one, but not both sites, suggesting a degree of redundancy under certain conditions. E2F1 increases the levels of endogenous EBP1 mRNA in breast carcinoma and other transformed cell lines. In contrast, in non-transformed primary epidermal keratinocytes, E2F, together with the retinoblastoma family of proteins, appears to be involved in decreasing EBP1 mRNA abundance in response to growth inhibition by transforming growth factor-β1. Thus, E2F is likely a central coordinator of multiple responses that culminate in regulation of EBP1 gene expression, and which may vary depending on cell type and context.

Pump Coupling & Motor bearing damage detection using Condition Monitoring at DTPS

Science.gov (United States)

Bari, H. M.; Deshpande, A. A.; Jalkote, P. S.; Patil, S. S.

2012-05-01

This paper shares a success story out of the implementation of Co-ordinated Condition Monitoring techniques at DTPS, wherein imminent Mis-alignment of HT auxiliary BFP - 1B and Motor bearing failure of ID FAN - 1B was diagnosed. On 30/12/2010, Booster Pump DE horizontal reading increased from 4.8 to 5.1 and then upto 5.9 mm/sec. It was suspected that Booster pump was mis-aligned with Motor. To confirm misalignment, Phase Analysis was also done which showed that Coupling phase difference was 180 Degrees. Vibration & Phase Analysis helped in diagnosing the exact root cause of abnormity in advance, saving plant from huge losses which could have caused total cost of £ 104,071. On 06/01/2011, ID fan 1B Motor NDE & DE horizontal vibration readings deviated from 0.5 to 0.8 and 0.6 to 0.8 mm/sec (RMS) respectively. Noise level increased from 99.1 to 101.9 db. It was suspected that Motor bearings had loosened over the shaft. Meanwhile, after opening of Motor, Inner race of NDE side was found cracked and loosened over the shaft. Vibration Analysis & Noise Monitoring helped in diagnosing the exact root cause of abnormity in advance, saving plant from huge losses which could have caused total cost of £ 308,857.

Evaluation of 6-([18F] fluoroacetamido)-1-hexanoic-anilide (18F-FAHA) as imaging probe in tumor xenograft mice model

Science.gov (United States)

Li, Fiona; Cho, Sung Ju; Yu, Lihai; Hudson, Robert H. E.; Luyt, Leonard G.; Pin, Christopher L.; Kovacs, Michael S.; Koropatnick, James; Lee, Ting-Yim

2016-03-01

Alteration in genetic expression is as important as gene mutation in cancer development and proliferation. Epigenetic changes affect gene expression without altering the DNA sequence. Histone deacetylase (HDAC), an enzyme facilitating histone remodelling, can lead to silencing of tumor suppressor genes making HDAC inhibitors viable anticancer drugs against tumors with increased activity of the enzyme. In this study we evaluated 18F-fluroacetamido-1-hexanoicanilide (18F-FAHA), an artificial HDAC substrate, as imaging probe of HDAC activity of human tumor xenografts in immunocompromised host mice. Human breast and melanoma cell lines, MDA-MB-468 and MDA-MB-435 respectively, known to overexpress HDAC activity were xenografted into immunocompromised mice and HDAC activity was imaged using 18F-FAHA. The melanoma group was treated with saline, SAHA (suberoylanilide hydroxamic acid, an approved anticancer HDAC inhibitor) in DMSO, or DMSO as positive control. Tracer kinetic modelling and SUV were used to estimate HDAC activity from dynamic PET data. Both breast tumor and melanoma group showed great variability in binding rate constant (BRC) of 18F-FAHA suggesting highly variable inter- and intra-tumoral HDAC activity. For the SAHA treated melanoma group, HDAC activity, as monitored by BRC of 18F-FAHA, decreased more than the two (positive and negative) control groups but not tumor growth. Our preliminary study showed that noninvasive PET imaging with 18F-FAHA has the potential to identify patients for whom treatment with HDAC inhibitors are appropriate, to assess the effectiveness of that treatment as an early marker of target reduction, and also eliminate the need for invasive tissue biopsy to individualize treatment.