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Sample records for con isquemia silente

  1. Isquemia miocárdica silente en diabéticos tipo 2 Silent myocardial ischemia in type 2 diabetes patients

    Directory of Open Access Journals (Sweden)

    Yordanka Piña Rivera

    2012-08-01

    Full Text Available Objetivos: determinar la frecuencia de isquemia miocárdica silente en diabéticos tipo 2 y su relación con el control metabólico. Métodos: se realizó un estudio descriptivo transversal en 79 pacientes asintomáticos con diabetes mellitus tipo 2 sin antecedentes de cardiopatía isquémica, hipertensión arterial o de ser fumador, que acudieron a la Consulta de Endocrinología del Hospital Militar Central "Dr. Carlos J. Finlay", entre febrero de 2009 y febrero de 2011. Se les realizó ecocardiografía con doppler tisular y se determinaron los niveles de glucemia en ayunas, posprandial, hemoglobina glucosilada, colesterol y triglicéridos. Las variables clínicas analizadas en relación con la isquemia miocárdica silente fueron: edad, sexo, tiempo de evolución de la diabetes e índice de masa corporal. Para las variables cualitativas se utilizaron distribuciones de frecuencia con el cálculo del porcentaje y para establecer relación entre variables la prueba de chi cuadrado. Resultados: la edad media del total de pacientes fue de 54 años, de ellos el 69,1 % correspondió al sexo masculino y el 31,9 % al femenino. En el 20,2 % de los pacientes se observaron signos de isquemia miocárdica por doppler tisular, y de ellos, un 75 % tuvo niveles patológicos de colesterol total, con relación estadísticamente significativa (p= 0,01, sujetos que tuvieron 4,4 veces más riesgo relativo de presentar isquemia miocárdica, que los pacientes con colesterol normal. Las cifras de glucemia en ayunas, posprandial y hemoglobina glucosilada fueron significativamente mayor en el grupo con isquemia. Los pacientes con niveles elevados de glucemia en ayunas tuvieron 10,5 veces más riesgo de isquemia miocárdica que los que tenían cifras adecuadas. Igualmente, los casos con cifras elevadas de glucemia posprandial presentaron 12 veces más riesgo de enfermar. Conclusiones: la isquemia miocárdica silente es frecuente en los diabéticos tipo 2 y se relaciona

  2. Non invasive evaluation of the coronary atherosclerosis illness in patients with silent ischemia: utility of the SPECT of myocardial perfusion. Electric, angiographic and image correlation; Valoracion no invasiva de la enfermedad ateroesclerosa coronaria en pacientes con isquemia silente: utilidad del SPECT de perfusion miocardica. Correlacion electrica, angiografica y de imagen

    Energy Technology Data Exchange (ETDEWEB)

    Puente B, A.; Roffe G, F.; Aceves C, J.; Gomez A, E. [Hospital Centro Medico Nacional 20 de Noviembre, ISSSTE, Mexico D.F. (Mexico)

    2005-07-01

    The objective of the work was to determine the utility of the SPECT (Single Photon Emission Computerized Tomography) of myocardial perfusion for the ischemia detection in asymptomatic patients with Coronary Atherosclerosis Illness. It was concluded that the SPECT of myocardial perfusion has a high sensitivity (97%) for the silent ischemia diagnosis.

  3. Registro de pacientes con esclerodermia. Desarrollo de una herramienta clínica para la detección precoz de úlceras digitales complicadas e isquemia grave.

    OpenAIRE

    Sánchez Quirós, Belén

    2017-01-01

    La esclerosis sistémica es una enfermedad rara del tejido conectivo que se caracteriza por el engrosamiento de la piel y la afectación de diferentes órganos internos. El fenómeno de Raynaud (FR) suele ser la primera manifestación apareciendo en la mayoría de los pacientes y provocando isquemia. Sin embargo, las úlceras digitales (UD) solo están presentes en el 30%. La detección precoz de UD incipientes, con la consiguiente aplicación de un tratamiento adecuado, evitará pérdida de la capacidad...

  4. Calidad de vida en pacientes con isquemia crónica de miembros inferiores tratados con células madre adultas Quality of life in patients with chronic lower limb ischemia treated with adult stem cells

    Directory of Open Access Journals (Sweden)

    Amel Alfonso-Simón

    2012-12-01

    Full Text Available Se hizo una evaluación de la calidad de vida en 45 pacientes mayores de 60 años con isquemia arterial crónica de miembros inferiores; de ellos, 34 con isquemia severa y 11 con pie diabético isquémico, también con lesiones severas. A todos se les habían implantado en el miembro inferior afectado, células mononucleares derivadas de la médula ósea movilizadas a la sangre periférica con factor estimulador de colonias de granulocitos. Para la evaluación de la calidad de vida se seleccionó el cuestionario SF-36, que centra su contenido en 2 áreas: el estado funcional y el bienestar emocional. En todos los casos se manifestó una mala calidad de vida preimplante. La mejoría fue evidente a partir del sexto mes después de la terapia celular. Los casos con un año de evolución habían logrado una buena calidad de vida. La mayor parte de los pacientes que evolucionaron satisfactoriamente pudieron incorporarse a las actividades sociales y laborales, lo que con anterioridad no les era posible.An assessment of the quality of life in 45 patients older than 60 years with chronic arterial ischemia of the lower limbs was conducted. Out of them, 34 had severe ischemia, and 11 had ischemic diabetic foot, as well as severe injuries. All had been implanted mononuclear cells in the affected lower limb, which derived from the bone marrow, and mobilized to the peripheral blood with granulocyte colony stimulating factor. For assessing quality of life, SF-36 questionnaire was selected, which focuses its content on two areas: functional status and emotional well being. All cases showed poor quality of life before implantation. Improvement was evident on the sixth month after cell therapy. Cases with a year of evolution had achieved good quality of life. Most of the patients, who had successful outcomes, could join social activities and employment, which was previously not possible.

  5. Déficit de antitrombina III como causa de isquemia mesentérica

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    Diego-Fernando Moreno-Sanchez

    2016-06-01

    Full Text Available La isquemia mesentérica es una patología poco frecuente, considerada una urgencia vascularcon una mortalidad elevada que requiere un tratamiento oportuno. Tiene una presentaciónclínica inespecífica, haciendo que la sospecha diagnóstica sea difícil, pero ayudas de imágenescomo la angiografía por tomografía computarizada confirman el diagnostico anteuna sospecha clínica. La etiología va desde enfermedades autoinmunes, medicamentos,arritmias cardiacas hasta trombofilias. Presentamos el caso de un paciente con déficit deantitrombina III (AT III quien debuta con una isquemia mesentérica.

  6. Isquemia aguda de miembros inferiores secundaria a ergortismo

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    Franco J. Vallejo, MD

    2011-11-01

    Full Text Available Paciente de género femenino, de 21 años de edad, quien ingresó por dolor progresivo e intenso en miembros inferiores, y refirió antecedente reciente de ingestión de derivados del ergot. Al examen físico se observó ausencia de pulsos en ambos miembros inferiores. Por angiotomografia se documentó disminución severa, generalizada y bilateral, del calibre de los vasos arteriales de miembros inferiores. Se diagnosticó isquemia arterial aguda secundaria a ergotismo y se inició tratamiento con vasodilatadores y calcio-antagonistas, que resolvió los síntomas en su totalidad.

  7. 'Silent mentors'

    DEFF Research Database (Denmark)

    Douglas-Jones, Rachel

    2017-01-01

    Unlike cadaver donation in the West, which has to a large degree maintained the anonymity of the body used to teach medical students, the Taiwanese Tzu Chi Buddhist Silent Mentor programme at the centre of this article foregrounds the identity of the training cadaver as an essential element in me...... for medical pedagogy, body donation, and Buddhist practices prompted by this programme, putting the ‘Silent Mentors’ into conversation with the ‘new immortalities’ of this special issue....

  8. LA TERAPIA CELULAR EN EL TRATAMIENTO DE LA ISQUEMIA CRÍTICA DE EXTREMIDADES INFERIORES

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    Gallardo Y

    2006-07-01

    Full Text Available ABSTRACT:Critical limb ischaemia is the final phase of the peripheral arterial disease. The treatment consists of the revascularización, but sometimes, the medical treatment is the only therapeutic option before the amputation. The cellular therapy allows the possibility of dealing with diseases with the use alive cells. This paper is a review about the utilization of adult staminal cells in patients with critical limb ischaemia.RESUMENLa isquemia crítica de la extremidad es la fase final de la enfermedad arterial periférica. El tratamiento consiste en la revascularización, pero en ocasiones, el tratamiento médico es la única opción terapéutica antes de la amputación. La terapia celular permite la posibilidad de tratar enfermedades con el uso de células vivas. En este artículo se efectúa una revisión del uso de células madre adultas en pacientes con isquemia crítica de la extremidad.

  9. Silent Thyroiditis

    Science.gov (United States)

    Walker, Peter

    1984-01-01

    Silent or painless thyroiditis is a frequent cause of transient hyperthyroidism, which is characterized by recent onset of symptoms in a patient with a normal to modestly enlarged and firm thyroid gland. The hallmarks of the disease are the absence of thyroidal pain or tenderness and a markedly reduced radioiodine uptake. Histologically, the gland is characterized by an important lymphocytic infiltration, occasionally to the point of lymphoid follicle formation. However, other indices of an autoimmune cause are usually absent. The disease appears to have a predilection for the postpartum period. Relapses may occur with subsequent pregnancies. Otherwise, the course is usually benign and transient, requiring moderate doses of β-adrenergic blocking agents for symptomatic relief. No pathogenetic factors are known, but the disease may conceivably have an autoimmune basis, particularly in the postpartum patient. PMID:21278944

  10. Isquemia microvascular miocárdica, un compromiso asintomático en esclerosis sistémica

    OpenAIRE

    Rausch, Gretel

    2011-01-01

    La Esclerosis Sistémica (ES) es una enfermedad autoinmune y multisistémica, cuya afectación básica es una lesión vascular generalizada, que produce isquemia y fibrosis secundaria del tejido comprometido. El compromiso miocárdico primario (sin compromiso pulmonar o renal), es frecuente, y un grave factor de riesgo de muerte. Junto con la fibrosis pulmonar y la hipertensión pulmonar, es una de las principales causas de mortalidad. Facultad de Ciencias Médicas

  11. La atorvastatina protege las neuronas gabérgicas y dopaminérgicas del sistema nigroestriatal en un modelo experimental de isquemia cerebral focal transitoria en ratas

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    Angélica María Sabogal

    2014-06-01

    Full Text Available Introducción. La isquemia cerebral es la tercera causa de muerte y la primera de discapacidad permanente en el mundo. La atorvastatina es un fármaco neuroprotector prometedor para el tratamiento de la apoplejía; sin embargo, su acción sobre las poblaciones neuronales del sistema nigroestriatal después de la isquemia aún se desconoce. Objetivo. Evaluar el efecto de la atorvastatina sobre poblaciones gabérgicas y dopaminérgicas en regiones exofocales en un modelo de oclusión transitoria de la arteria cerebral media. Materiales y métodos. Se utilizaron 28 ratas Wistar macho de ocho semanas de edad. Los ejemplares con isquemia simulada y los ejemplares sometidos a isquemia fueron tratados con atorvastatina (10 mg/kg y carboximetilcelulosa (placebo administrados por medio de sonda a las 6, 24, 48 y 72 horas después de la reperfusión. Se analizó la inmunorreacción de la descarboxilasa del ácido glutámico y de la tirosina hidroxilasa en el globo pálido, el putamen caudado y la sustancia negra. Resultados. Los datos confirmaron el daño neurológico y la pérdida celular en el putamen caudado. Se incrementó la inmunorreacción de la tirosina hidroxilasa en el globo pálido medial y la sustancia negra pars reticulata, disminuyendo la inmunorreacción de la descarboxilasa del ácido glutámico en el globo pálido lateral de los animales isquémicos tratados con placebo; sin embargo, el tratamiento con atorvastatina pudo revertirla, lo que logró una disminución significativa de la tirosina hidroxilasa en el globo pálido medial y la sustancia negra pars reticulata y aumentando los niveles de descarboxilasa del ácido glutámico en el globo pálido lateral. Conclusión. Nuestros datos sugieren que la atorvastatina en el tratamiento posterior a la isquemia ejerce neuroprotección en las zonas exofocales, modulando las poblaciones neuronales gabérgicas y dopaminérgicas del sistema nigroestriatal, lo que podría prevenir trastornos neurológicos.

  12. Silent ischaemia and hypertension

    NARCIS (Netherlands)

    Boon, D.; Piek, J. J.; van Montfrans, G. A.

    2000-01-01

    For many years now, silent ischaemia has been recognized as a distinct clinical entity, and its relevance in different patient groups has been established. However, a number of basic questions have not been answered. In explaining the pathophysiology of silent ischaemia, factors affecting both the

  13. Análisis comparativo de marcadores de lesión en modelos de isquemia cerebral focal y global en ratas

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    Ángel Enrique Céspedes

    2013-06-01

    Full Text Available Introducción. Los indicadores espacio-temporales de lesión son esenciales en el estudio neuropatológico y terapéutico de la isquemia cerebral. Objetivo. Optimizar la técnica de dos modelos de isquemia cerebral (focal y global y hacer un análisis comparativo de la progresión del daño cerebral, mediante marcadores de neurodegeneración. Materiales y métodos. Se sometieron ratas Wistar a oclusión temporal de la arteria cerebral media o aoclusión de cuatro vasos, y se evaluaron comparativamente el tiempo quirúrgico, la tasa de supervivenciay la recuperación neurológica. Se utilizó trifenilo de tetrazolio para establecer la distribución del infarto y tinción con Fluoro-Jade B® como marcador de neurodegeneración. La inmunorreacción de la astroglía  se evaluó con el anticuerpo contra la proteína acídica fibrilar de la glía (Glial Fibrillary Acidic Protein,GFAP y el anticuerpo AT-8 contra la proteína tau hiperfosforilada, 24, 48 y 72 horas después de la isquemia. Resultados. Los modelos de isquemia utilizados requirieron menor tiempo quirúrgico y hubo menorriesgo de muerte, respecto a estudios previos. En el modelo focal, las células positivas con Fluoro-Jade B® y los astrocitos reactivos, se evidenciaron en corteza e hipocampo a las 24 horas después de la isquemia. En el modelo global, se observó tinción Fluoro-Jade B® positiva a las 24 horas, aumentando significativamente la reacción de la GFAP a las 72 horas en corteza y a las 48 horas en el hipocampo. La reacción contra la proteína tau hiperfosforilada aumentó progresivamente y fue máxima a las 72horas en ambos modelos. Conclusiones. Los dos modelos de isquemia cerebral, oclusión temporal de la arteria cerebral media y oclusión de cuatro vasos, fueron optimizados. En estos modelos, los marcadores la tinción Fluoro-Jade B® y la GFAP permitieron detectar procesos de neurodegeneración 24 horas después de la isquemia, en tanto el marcador de proteína tau

  14. Ornitina alfa-cetoglutarato na isquemia-reperfusÃo intestinal em ratos

    OpenAIRE

    Eduardo Silvio Gouveia GonÃalves

    2009-01-01

    Objetivo: Avaliar os efeito da ornitina α-cetoglutarato (OKG) no sangue e tecido intestinal de ratos submetidos à isquemia/reperfusÃo intestinal atravÃs da determinaÃÃo das concentraÃÃes in vivo no sangue e no tecido do intestino delgado, submetido a isquemia/reperfusÃo, de glicose, G 6 PDH, piruvato, acetoacetato, lactato, 3 HBDH, glutationa, T-Bars, mieloperoxidase, CPK e LDH. MÃtodo: Sessenta ratos (Rattus norvergicus albinus, Rodentia Mammalia) foram distribuÃdos aleatoriamente em ci...

  15. Efeitos da angiotensina-I e isquemia na recuperação funcional em corações isolados

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    Ubirajara Oliveira de Oliveira

    2011-11-01

    Full Text Available FUNDAMENTO: A ressuscitação de parada cardíaca pode apresentar disfunção miocárdica determinada pelo tempo da isquemia, e a inibição da enzima conversora de angiotensina (ECA pode reduzir a disfunção cardíaca durante a reperfusão. OBJETIVO: Investigar os efeitos da angiotensina-I e diferentes períodos de isquemia na recuperação funcional em corações de ratos isolados. MÉTODOS: Os corações isolados de ratos Wistar (n = 45; 250-300 g foram submetidos a diferentes períodos de isquemia global (20, 25 ou 30 min e reperfundidos (30 min com o tampão Krebs-Henseleit, ou com a adição de 400 nmol/L de angiotensina-I, ou com 400 nmol/L de angiotensina-I + 100 µmol/L de captopril durante o período de reperfusão. RESULTADOS: A derivada positiva máxima de pressão (+dP/dt max e o produto frequência-pressão foram reduzidos nos corações expostos à isquemia de 25 min (~ 73% e à isquemia de 30 min (~ 80% vs. isquemia de 20 min. A pressão diastólica final do ventrículo esquerdo (PDFVE e a pressão de perfusão (PP foram aumentadas nos corações expostos à isquemia de 25 min (5,5 e 1,08 vezes, respectivamente e à isquemia de 30 min (6 e 1,10 vezes, respectivamente vs. isquemia de 20 min. A angiotensina-I ocasionou uma diminuição no +dP/dt max e no produto frequência-pressão (~ 85-94% em todos os períodos de isquemia e um aumento na PDFVE e na PP (6,9 e 1,25 vezes, respectivamente apenas na isquemia de 20 min. O captopril foi capaz de reverter parcial ou completamente os efeitos da angiotensina-I na recuperação funcional nas isquemias de 20 e 25 min CONCLUSÃO: Os dados sugerem que a angiotensina-II participa direta ou indiretamente no dano pós-isquêmico e que a capacidade de um inibidor da ECA atenuar esse dano depende do tempo de isquemia.

  16. The threat of silent earthquakes

    Science.gov (United States)

    Cervelli, Peter

    2004-01-01

    Not all earthquakes shake the ground. The so-called silent types are forcing scientists to rethink their understanding of the way quake-prone faults behave. In rare instances, silent earthquakes that occur along the flakes of seaside volcanoes may cascade into monstrous landslides that crash into the sea and trigger towering tsunamis. Silent earthquakes that take place within fault zones created by one tectonic plate diving under another may increase the chance of ground-shaking shocks. In other locations, however, silent slip may decrease the likelihood of destructive quakes, because they release stress along faults that might otherwise seem ready to snap.

  17. Isquemia vertebrobasilar y síndrome de Locked-In

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    Jorge Daza Barriga

    2004-01-01

    Full Text Available Los eventos vasculares cerebrales de la arteria vertebrobasilar no son tan frecuentes como los que ocurren en la circulación anterior; pero se presentan con igual vulnerabilidad a la ateromatosis, a los fenómenos trombóticos, a los eventos embólicos y a las alteraciones vasoespásticas. Clínicamente, se presentan síntomas y signos combinados o mixtos de ataxia ipsilateral, hemiplejia contralateral con pérdida de la sensibilidad, parálisis ipsilateral horizontal de la mirada, nistagmus, vértigos, náuseas y vómitos, disfagia, sordera, acúfenos, mioclonus palatino y oscilopsia. Cuando el compromiso vascular compromete a la propia arteria basilar, los signos clínicos son bilaterales, con cuadriplegía, parálisis bilaterales de la mirada conjugada horizontal, coma, o el síndrome de deferentización (“Locked In” ó cautiverio. Estos mismos signos pueden producirse por la alteración de las arterias vertebrales o por patología unilateral, cuando una de las arterias vertebrales es la fuente dominante del aporte sanguíneo. La realización de una buena historia clínica y un examen cuidadoso nos dan una impresión clínica precisa. La realización de exámenes complementarios, como las imágenes diagnósticas (Escanografía cerebral simple, resonancia magnética cerebral, angioresonancia, son útiles para diferenciar si el evento es isquémico o hemorrágico, establecer el área de la isquemia y para definir las pautas diagnósticas y terapéuticas que se deben seguir El síndrome “Locked In” es un proceso destructivo (normalmente, obstructivo de la arteria basilar con el consiguiente infarto de tronco que interrumpe los tractos descendentes corticobulbares y corticoespinales, quedando intactas sólo las fibras que controlan el parpadeo, los movimientos oculares verticales y a la sustancia reticular ascendente. El paciente sólo es capaz de comunicarse mediante parpadeos o movimientos oculares verticales, ya que todo lo demás est

  18. Sistema inteligente de reconocimiento de enfermedad coronaria (isquemia)

    OpenAIRE

    Clavijo Rodriguez, Diana Lucia; Bernal Valencia, Marcelo; Silva, John Freddy

    2012-01-01

    Este artículo trata de la inteligencia artificial en la Medicina. En este caso, se trata de describir todo el implicaciones Technologies en esta área. Es muy importante tener en cuenta los cambios que seel mundo está sufriendo con la evolución de cómputo, más, si se está hablando de cuidado de la salud. Pronto, la gente va a contar con una gran cantidad de aplicaciones de inteligencia artificial enla medicina que podría ayudar a todo el mundo para desarrollar problemas más fácil y más rápido ...

  19. Monitoring Progress toward Independent Silent Reading.

    Science.gov (United States)

    Franc, Lillian H.; Hildebrandt, Jeannette

    1984-01-01

    Concludes, among other things, that fluent oral reading is an important step toward reading for meaning and independent silent reading and that silent reading should be encouraged from the beginning of reading instruction. (FL)

  20. PROTEÇÃO FUNCIONAL DO RIM COM LOVASTATINA APÓS ISQUEMIA E REPERFUSÃO RENAL

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    Leal D. M.

    2001-01-01

    Full Text Available Introdução - a isquemia renal é causa de graves lesões nesse órgão, estando presente em diferentes situações como em cirurgias renais, vasculares e no transplante renal. Assim, a procura de substâncias protetoras da função renal tem amplo interesse clínico. Neste estudo o objetivo foi o de analisar o efeito da lovastatina na isquemia renal normotérmica seguida da reperfusão.

  1. Base eletronica de dados clinicos e cirurgicos em isquemia cronica de membros inferiores

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    Carlos Seme Nejm Junior

    2013-09-01

    Full Text Available CONTEXTO: Um sistema eletrônico de protocolo seria capaz de armazenar dados clínicos e possibilitar futuras pesquisas, visando a rapidez, eficiência de cruzamentos e análise de tais dados. OBJETIVO: a criar uma base de dados clínicos cirúrgicos em doenças vasculares e, a partir desta, uma base em Isquemia Crônica de Membros Inferiores; b informatizar essa base sob forma de um protocolo eletrônico; c incorporar ao SINPE(c (Sistema Integrado de Protocolos Eletrônicos; d realizar um projeto piloto. MÉTODOS: Criou-se uma base teórica de dados clínicos sobre as doenças vasculares. O protocolo específico foi criado considerando-se as características individuais das doenças causadoras de Isquemia Crônica de Membros Inferiores. Após seu término, essa base eletrônica e informatizada seria incorporada ao SINPE(c. RESULTADOS: O usuário, previamente cadastrado, realizará o cadastro do paciente e selecionará, dentro do protocolo mestre, o protocolo específico em Isquemia Crônica de Membros Inferiores, para acesso aos seus respectivos dados clínicos. Orientado pelas alternativas diretas de preenchimento, o usuário seleciona apenas os dados pertencentes ao seu paciente. Estes podem ser resgatados para pesquisa, mostrando o número de coletas que satisfazem os parâmetros escolhidos e informações estatísticas sobre a mesma. CONCLUSÃO: a a criação da base teórica de dados clínicos e cirúrgicos em doenças vasculares e, a partir desta, em Isquemia Crônica de Membros Inferiores, foi factível; b a informatização da base teórica sob forma de protocolo eletrônico foi exequível; c o protocolo eletrônico mestre e específico poderá ser incorporado ao SINPE(c, d o projeto piloto foi criado com sucesso e testado através do módulo analisador do SINPE(c.

  2. LA TERAPIA CELULAR EN EL TRATAMIENTO DE LA ISQUEMIA CRÍTICA DE EXTREMIDADES INFERIORES

    OpenAIRE

    Gallardo Y; Hermida G; Fonseca Legrand JL; Cuevas-Ruiz B

    2006-01-01

    ABSTRACT:Critical limb ischaemia is the final phase of the peripheral arterial disease. The treatment consists of the revascularización, but sometimes, the medical treatment is the only therapeutic option before the amputation. The cellular therapy allows the possibility of dealing with diseases with the use alive cells. This paper is a review about the utilization of adult staminal cells in patients with critical limb ischaemia.RESUMENLa isquemia crítica de la extremidad es la fase final de ...

  3. Unusual ocular manifestations of silent sinus syndrome

    OpenAIRE

    Fonseca, Fabricio Lopes da; Mazoti, Luciana; Polati, Mariza

    2014-01-01

    Silent sinus syndrome is an acquired condition in which there is a gradual collapse of the orbital floor and inward retraction of the maxillary sinus (atelectasis of the maxillary sinus). This in turn may cause associated ocular occurrences of enophthalmos and hypotropia. This is a report of an 8 year-old boy with silent sinus syndrome and associated ocular motility disorders. The association between silent sinus syndrome and ocular motility disturbance has been recently described in the lite...

  4. Prevalência de isquemia induzida por estresse mental Prevalence of induced ischemia by mental distress

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    Gustavo Borges Barbirato

    2010-03-01

    Full Text Available FUNDAMENTOS: A cintilografia miocárdica com estresse mental parece induzir isquemia através de uma fisiopatologia particular quando comparada com a cintilografia, utilizando o estresse físico ou farmacológico. OBJETIVO: Avaliar a prevalência de isquemia miocárdica induzida por estresse mental, em pacientes com dor torácica e cintilografia com estresse convencional normal, utilizando 99mTc-Sestamibi. MÉTODOS: 22 PAcientes foram admitidos com dor torácica na emergência, ou foram encaminhados ambulatorialmente ao serviço de medicina nuclear da nossa instituição, onde realizaram cintilografia miocárdica de estresse e repouso sem alterações isquêmicas. Então, foram convidados a realizar uma fase adicional com indução de estresse mental através do conflito de cores (Stroop Color Test com o objetivo de detectar isquemia miocárdica. Dois cardiologistas e médicos nucleares realizaram a análise cega dos dados perfusionais e consequente quantificação através do SDS (Summed Diference Score, pontuando os segmentos com alteração perfusional após o estresse mental e comparando com a imagem de repouso. A presença de isquemia miocárdica foi considerada com SDS > 3. RESULTADOS: A prevalência de isquemia miocárdica induzida por estresse mental foi de 40% (9 pacientes positivos. Nos 22 pacientes estudados não houve diferença estatística quanto ao número de fatores de risco, alterações hemodinâmicas induzidas pelo estresse mental, uso de medicações, sintomas apresentados, presença ou ausência de doença coronariana e variações da fração de ejeção e volume sistólico final do Gated SPECT. CONCLUSÃO: EM Uma amostra selecionada de pacientes com dor torácica e cintilografia miocárdica convencional normal, a pesquisa de isquemia miocárdica induzida pelo estresse mental através de cintilografia pode ser positiva em até 40% dos casos.BACKGROUND: The myocardial radionuclide imaging with mental distress seems to induce

  5. Alterações enzimáticas decorrentes de isquemia muscular esquelética em ratos

    Directory of Open Access Journals (Sweden)

    Ely Jorge Fonseca

    2000-01-01

    Full Text Available Os autores estudaram as alterações enzimáticas [transaminase oxalo-acética (TGO, creatinofosfoquinase (CPK e desidrogenase lática (LDH] decorrentes de isquemia muscular esquelética em ratos submetidos à isquemia de membro inferior por 0, 2, 4 e 6 horas. Vinte e oito ratos Wistar foram divididos em 4 grupos: Grupo I (controle; e Grupos II, III, e IV (isquemia por 2, 4 e 6 horas, respectivamente. Após o período de isquemia, foi coletado sangue do plexo retrocular para análise laboratorial. Os valores obtidos (média±desvio padrão para TGO nos Grupos I, II, III e IV foram, respectivamente: 20,14±6,76; 59,71±28,91; 88,28±11,17 e 123±52,65 U/l. Para CPK, os valores foram: 67,85±62,76; 203±108,71; 237,71±95,06 e 291,71±173,19 U/l. Para LDH, obteve-se: 334,14±117,13; 414,42±222,47; 526±234,75 e 427,57±273,58 U/l. Para análise estatística, utilizou-se o método de ANOVA, seguido do teste t de Bonferroni (p<0,05. Os níveis de TGO foram significativamente superiores nos grupos III e IV quando comparados ao controle. Para CPK, houve distinção significativa entre os grupos IV e I. Os níveis de LDH não se demonstraram estatisticamente diferentes entre os grupos. Os autores concluem que em períodos de isquemia por 2, 4 e 6 horas, a dosagem de LDH não se mostra um parâmetro útil na avaliação de dano muscular esquético. A TGO e CPK tiveram alterações significativas a partir de 4 e 6 horas, respectivamente, mostrando-se úteis na avaliação de isquemia muscular em ratos.

  6. Underlying skills of oral and silent reading

    NARCIS (Netherlands)

    Van Den Boer, Madelon; van Bergen, Elsje; de Jong, Peter F.

    2014-01-01

    Many studies have examined reading and reading development. The majority of these studies, however, focused on oral reading rather than on the more dominant silent reading mode. Similarly, it is common practice to assess oral reading abilities rather than silent reading abilities in schools and in

  7. The prevalence and quality of silent, socially silent, and disclosed autobiographical memories across adulthood.

    Science.gov (United States)

    Alea, Nicole

    2010-02-01

    Two separate studies examined the prevalence and quality of silent (infrequently recalled), socially silent (i.e., recalled but not shared), and disclosed autobiographical memories. In Study 1 young and older men and women remembered positive events. Positive memories were more likely to be disclosed than to be kept socially silent or completely silent. However, socially silent and disclosed memories did not differ in memory quality: the memories were equally vivid, significant, and emotional. Silent memories were less qualitatively rich. This pattern of results was generally replicated in Study 2 with a lifespan sample for both positive and negative memories, and with additional qualitative variables. The exception was that negative memories were kept silent more often. Age differences were minimal. Women disclosed their autobiographical memories more, but men told a greater variety of people. Results are discussed in terms of the functions that memory telling and silences might serve for individuals.

  8. Silent Patent Ductus Arteriosus Aneurysm

    Directory of Open Access Journals (Sweden)

    Aline Medeiros Botta

    2002-09-01

    Full Text Available Ductus arteriosus aneurysm, a rare and potentially fatal condition, has been reported as a complication after surgical ductus arteriosus closure. Its spontaneous appearance as a septic complication, which was common in the presurgical and preantibiotic era, has been rarely reported in the contemporary literature. Persistence of silent ductus arteriosus in healthy children and adults is a frequent condition that currently has an increasing diagnostic possibility due to the availability of more accurate investigative methods, especially echocardiography. We report the case of a 1-year-old child, in whom no previous heart disease was known, who developed a giant aneurysm of the ductus arteriosus during a staphylococcal infection. This complication appeared after craniotomy for emptying an accidental subdural hematoma. This report associates the persistence of ductus arteriosus with a complication considered rare, which has a rapidly fatal evolution.

  9. Expressao genica associada ao estresse oxidativo no coracao de camundongo apos isquemia intestinal

    Directory of Open Access Journals (Sweden)

    Frederico Somaio Neto

    2014-03-01

    Full Text Available FUNDAMENTO: O fenômeno da isquemia e reperfusão intestinal é um evento frequente na clínica e está associado a repercussões deletérias em órgãos a distância, em especial ao coração. OBJETIVO: Investigar a expressão gênica do estresse oxidativo e defesa antioxidante no coração de camundongos isogênicos, submetidos a isquemia e reperfusão intestinal (IR. MÉTODOS: Doze camundongos (C57BL/6 foram distribuídos em dois grupos: Grupo IR (GIR com 60 min de oclusão da artéria mesentérica superior, seguidos de 60 min de reperfusão. Grupo Controle (GC submetidos a anestesia e a laparotomia sem o procedimento de IR observados por 120 min. As amostras de intestino e coração foram processadas pelo método (RT-qPCR / Reverse transcriptase - quantitative Polymerase Chain Reaction para determinar a expressão gênica de 84 genes relacionados ao estresse oxidativo ("t" de Student, p < 0,05. RESULTADOS: Observou-se no tecido intestinal (GIR uma expressão significantemente aumentada em 65 (74,71% genes em relação ao tecido normal (GC, e 37 (44,04% genes estiveram hiperexpressos (maior que três vezes o limiar permitido pelo algoritmo. No tocante aos efeitos da I/R intestinal a distância no tecido cardíaco verificou-se a expressão significantemente aumentada de 28 genes (33,33%, mas somente oito genes (9,52% se hiperexpressaram três vezes acima do limiar. Quatro (7,14% desses oito genes se expressaram simultaneamente nos tecidos intestinal e cardíaco. No GIR notaram-se cardiomiócitos com núcleos de menor tamanho, picnóticos, ricos em heterocromatina e raros nucléolos, indicando sofrimento cardíaco. CONCLUSÃO: A I/R intestinal promoveu a hiperexpressão estatisticamente significante de oito genes associados ao estresse oxidativo a distância no tecido miocárdico.

  10. Characteristics of silent countingin synchronized swimmers

    Directory of Open Access Journals (Sweden)

    Sergey V. Leonov

    2012-01-01

    Full Text Available This article describes the temporal characteristics of silent counting as used duringa competition by the Russian youth team of synchronized swimmers. Theathletes listened to the music that accompanied their performance at the competition.Diff erent indices of silent counting were defi ned, such as the beginningand cessation of diff erent periods of counting, counting frequency, the stabilityof the temporal structure of silent counting, the degree of synchronization of silentcounting at diff erent moments during the sports program. We studied therelationship of these characteristics of counting with expert estimates of the athletes’sense of tempo, coordination of movements, and choreographic abilities.

  11. Unusual ocular manifestations of silent sinus syndrome

    Directory of Open Access Journals (Sweden)

    Fabricio Lopes da Fonseca

    2014-01-01

    Full Text Available Silent sinus syndrome is an acquired condition in which there is a gradual collapse of the orbital floor and inward retraction of the maxillary sinus (atelectasis of the maxillary sinus. This in turn may cause associated ocular occurrences of enophthalmos and hypotropia. This is a report of an 8 year-old boy with silent sinus syndrome and associated ocular motility disorders. The association between silent sinus syndrome and ocular motility disturbance has been recently described in the literature. However, this is an infrequent association, mainly in childhood.

  12. Avaliação do papel do sistema canabidiol em um modelo de lesão renal por isquemia/reperfusão em animais

    Directory of Open Access Journals (Sweden)

    Rodrigo Zon Soares

    2015-12-01

    Full Text Available RESUMO Objetivo: Investigar os efeitos da administração de canabidiol em um modelo de isquemia/reperfusão renal em animais. Métodos: Foi induzida uma lesão renal, por meio de 45 minutos de isquemia renal seguida por reperfusão. Administrou-se canabidiol (5mg/kg imediatamente após a reperfusão. Resultados: A isquemia/reperfusão aumentou os níveis de interleucina 1 e fator de necrose tumoral, o que foi atenuado pelo tratamento com canabidiol. Além disso, o canabidiol foi capaz de diminuir o dano oxidativo de lipídios e proteínas, mas não os níveis de nitrito/nitrato. A lesão renal após isquemia/reperfusão pareceu ser independente da expressão dos receptores canabidiol-1 e canabidiol-2, já que não houve aumento significante desses receptores após a reperfusão. Conclusão: O tratamento com canabidiol teve um efeito protetor contra a inflamação e o dano oxidativo em um modelo de isquemia/reperfusão renal. Esses efeitos parecem não ocorrer via ativação dos receptores canabidiol-1/canabidiol-2.

  13. La atorvastatina protege las neuronas gabérgicas y dopaminérgicas del sistema nigroestriatal en un modelo experimental de isquemia cerebral focal transitoria en ratas

    OpenAIRE

    Angélica María Sabogal; Cesar Augusto Arango; Gloria Patricia Cardona; Ángel Enrique Céspedes

    2014-01-01

    Introducción. La isquemia cerebral es la tercera causa de muerte y la primera de discapacidad permanente en el mundo. La atorvastatina es un fármaco neuroprotector prometedor para el tratamiento de la apoplejía; sin embargo, su acción sobre las poblaciones neuronales del sistema nigroestriatal después de la isquemia aún se desconoce. Objetivo. Evaluar el efecto de la atorvastatina sobre poblaciones gabérgicas y dopaminérgicas en regiones exofocales en un modelo de oclusión transitoria de ...

  14. Myocardial perfusion in silent myocardial ischemia

    International Nuclear Information System (INIS)

    Narita, Michihiro; Kurihara, Tadashi; Murano, Kenichi; Usami, Masahisa

    1989-01-01

    To investigate myocardial perfusion in silent myocardial ischemia, we performed exercise stress myocardial tomography with thallium-201 (Tl) in 85 patients with coronary artery disease (CAD). Exercise stress myocardial tomography was obtained both immediately after exercise and three hours later. Patients were classified into two groups according to the presence (Symptomatic Group, n=36) or absence (Silent Group, n=49) of chest pain during exercise stress. Clinical features (age, gender and history of myocardial infarction) and arteriographically determined severity of CAD were the same in both groups. The extent of myocardial ischemia (% Ischemia) estimated by exercise stress myocardial tomography was the same in each group (30±10 % in Silent Group, 28±12 % in Symptomatic Group, NS). The severity of exercise-induced myocardial ischemia was expressed as a minimal value of myocardial Tl washout rate (minimal WOR) of each patient. Although exercise heart rate was identical in both groups, minimal WOR in Silent Group was significantly higher than that of Symptomatic Group (4±10% vs -16±14%, p<0.001). The study in patients who exhibited both silent and symptomatic ischemia showed the same results. These findings suggest that the severity of ischemia is a fundamental factor in determining the presence or absence of pain during exercise induced ischemia. (author)

  15. Prevalência de isquemia miocárdica na cintilografia em mulheres nos períodos pré/pós-menopausa

    Directory of Open Access Journals (Sweden)

    Daniel Augusto Message dos Santos

    2013-12-01

    Full Text Available FUNDAMENTO: No período pós-menopausa, a presença dos fatores de risco para doença arterial coronária (DAC aumentam. Entretanto, não é bem estabelecida a diferença de prevalência de isquemia miocárdica em mulheres pré/pós-menopausa com múltiplos fatores de risco para DAC. OBJETIVO: Comparar a prevalência de isquemia na cintilografia de perfusão miocárdica com sestamibi-99mTc (CPM em mulheres nos períodos pré/pós-menopausa e avaliar se a menopausa pode ser considerada fator preditor de risco independente para isquemia em mulheres com múltiplos fatores de risco para DAC. MÉTODOS: Analisamos, retrospectivamente, 500 CPM de mulheres pré/pós-menopausa, com múltiplos fatores de risco cardiovascular. A análise estatística foi realizada por teste exato de Fisher e pelas análises univariada e multivariada, sendo considerado significativo o valor de p < 0,05. RESULTADOS: Do total, 55,9% das mulheres estavam no período pós-menopausa, 83,3% eram hipertensas, 28,9% diabéticas, 61,2% dislipidêmicas, 32,1% tabagistas, 25% obesas e 34,3% já apresentavam DAC conhecida. No grupo pós-menopausa, as mulheres eram mais hipertensas, diabéticas e dislipidêmicas, e tiveram menor capacidade funcional no teste ergométrico (p = < 0,005. Não houve diferença estatística significativa na presença de isquemia na CPM entre os grupos pré/pósmenopausa (p = 0,395. A única variável associada à isquemia na CPM foi a presença de DAC prévia (p = 0,004. CONCLUSÃO: Os resultados obtidos sugerem que, em mulheres com múltiplos fatores de risco para DAC, a menopausa não foi fator preditor independente de isquemia na CPM. Essas informações reforçam a ideia de que a investigação de isquemia pela CPM em mulheres com múltiplos fatores de risco para DAC talvez deva iniciar antes da menopausa.

  16. Purely Magnetic Silent Universes do not Exist

    Science.gov (United States)

    Vu, K. T.; Carminati, J.

    2008-09-01

    We present a new Maple package called STeM (Symbolic Tetrad Manipulation). Using STeM, we outline, using a formalism which is a hybrid of the NP and Orthonormal ones, the proof of the nonexistence of purely magnetic silent universes.

  17. Relativistic numerical cosmology with silent universes

    Science.gov (United States)

    Bolejko, Krzysztof

    2018-01-01

    Relativistic numerical cosmology is most often based either on the exact solutions of the Einstein equations, or perturbation theory, or weak-field limit, or the BSSN formalism. The silent universe provides an alternative approach to investigate relativistic evolution of cosmological systems. The silent universe is based on the solution of the Einstein equations in 1  +  3 comoving coordinates with additional constraints imposed. These constraints include: the gravitational field is sourced by dust and cosmological constant only, both rotation and magnetic part of the Weyl tensor vanish, and the shear is diagnosable. This paper describes the code simsilun (free software distributed under the terms of the reposi General Public License), which implements the equations of the silent universe. The paper also discusses applications of the silent universe and it uses the Millennium simulation to set up the initial conditions for the code simsilun. The simulation obtained this way consists of 16 777 216 worldlines, which are evolved from z  =  80 to z  =  0. Initially, the mean evolution (averaged over the whole domain) follows the evolution of the background ΛCDM model. However, once the evolution of cosmic structures becomes nonlinear, the spatial curvature evolves from ΩK =0 to ΩK ≈ 0.1 at the present day. The emergence of the spatial curvature is associated with ΩM and Ω_Λ being smaller by approximately 0.05 compared to the ΛCDM.

  18. The Silent Spring of Rachel Carson.

    Science.gov (United States)

    Kerstetter, Ned

    1996-01-01

    Presents a lesson plan examining Rachel Carson's call to arms concerning the harmful consequences of pesticides. Students view a video documentary on Carson's work and read a synopsis of her book, "Silent Spring." Assessment is provided by various activities including writing assignments, creating posters, and editorial cartoons. (MJP)

  19. Malaria - Africa's silent tsunami | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2011-01-12

    Jan 12, 2011 ... Less well known is the continuous “silent tsunami” of malaria in Africa ... This means almost 3 lives per minute lost from an easily preventable and treatable disease. It was gratifying to see the beginnings of similar passion to deal with ... often in shapes, sizes, and colours unpopular in African households.

  20. Silent Film in the German Classroom.

    Science.gov (United States)

    Caldwell, David

    In addition to using films in the German classroom to introduce students to German culture and history, it is important to show and study the film as film. This procedure emphasizes the importance of the film as a part of creative arts in Germany and demands student participation in observation and discussion. Many German silent films are…

  1. Efeito do alopurinol e terapia com oxigênio hiperbárico em modelo de reimplante de membro após isquemia quente em ratos

    Directory of Open Access Journals (Sweden)

    Marcelo Sacramento Cunha

    Full Text Available OBJETIVO: A isquemia prolongada leva a alterações na microcirculação tecidual e liberação de radicais livres do oxigênio conhecidas como fenômeno de não reperfusão. Foi testado um modelo experimental de reimplante de membro após isquemia quente e os efeitos do fármaco alopurinol e da terapia com oxigênio hiperbárico. MÉTODO: Foram realizadas amputações com preservação dos vasos e nervos dos membros posteriores direitos em 95 ratos. Os grupos modelos M1, M2, M3, M4 e M5 foram submetidos à isquemia quente de 0, 2, 4, 6 e 8 horas. As taxas de viabilidade dos membros isquêmicos após sete dias de avaliação foram 100%, 80%, 63,6%, 50% e 20%. Os grupos experimentais E1 e E2 foram tratados, respectivamente, com alopurinol e terapia com oxigênio hiperbárico após isquemia de 6 horas. As taxas de viabilidade foram 70% e 30%. Os resultados foram analisados estatisticamente pelo teste do Qui-quadrado. RESULTADOS: Os grupos M1, M2, M3, M4 e M5 foram estatisticamente diferentes entre si exceto os grupos M3 e M4. E1 resultou em uma viabilidade de membros maior que M4 e E2 resultou em uma viabilidade de membros menor que M4(resultados estatisticamente significantes. CONCLUSÕES: Os resultados sugerem que a administração do alopurinol após isquemia do membro por 6 horas aumenta a taxa de viabilidade dos membros isquêmicos, e a terapia com oxigênio hiperbárico diminuiu a viabilidade dos membros isquêmicos.

  2. Efeitos do alfa-tocoferol nas lesões de isquemia-reperfusão induzidas em pata direita de ratos

    Directory of Open Access Journals (Sweden)

    Bitu-Moreno José

    2001-01-01

    Full Text Available Recentes estudos demonstraram que os radicais livres de oxigênio parecem desempenhar papel importante nas lesões de isquemia-reperfusão. O alfa-tocoferol(AT age in vivo como um anti-oxidante. Nosso objetivo foi o de verificar se o AT atenuava as lesões de isquemia-reperfusão em pata direita de ratos. Os animais, randomizados, foram divididos nos seguintes grupos(G: G1-controle sem isquemia; G2 e G3 - quatro horas isquemia e duas reperfusão. Os animais do G2 foram tratados com salina e os do G3 com AT, 50mg/kg. Como parâmetros examinamos as alterações de volume e circunferência do pé direito ao longo do experimento, assim como a captação de 99mTc-pirofosfato e a microscopia eletrônica de transmissão do músculo soleus direito. Os aumentos de volume e circunferência do pé dos animais do G2 foram estatisticamente maiores quando comparados com o G1. As medidas do G3 não diferiram do G1. A captação de 99mTc-pirofosfato foi bem aumentada nos G2 e G3, quando comparados ao G1, porém sem diferenças entre os grupos isquêmicos. As lesões ao MET foram menos intensas em três animais do G3, quando comparados ao G2. Conclusão: O tratamento com AT diminuiu a formação do edema mas só protegeu parcialmente as células musculares contra as lesões de isquemia-reperfusão.

  3. Experiencia inicial con la prótesis de despliegue rápido en posición aórtica Edwards Intuity

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    José M. Arribas

    2016-03-01

    Conclusiones: El implante de la válvula Edwards Intuity para el tratamiento de la estenosis aórtica ha sido factible, seguro y eficaz. Los tiempos de isquemia miocárdica y de circulación extracorpórea parecen reducirse en comparación con la cirugía valvular aórtica habitual. El comportamiento hemodinámico inicial de la prótesis Edwards Intuity es excelente.

  4. Silent stroke and advance in neuroimaging

    Energy Technology Data Exchange (ETDEWEB)

    Okada, Yasushi; Sadoshima, Seizo; Hasuo, Kanehiro; Saku, Yoshisuke; Fujishima, Masatoshi (Kyushu Univ., Fukuoka (Japan). Faculty of Medicine)

    1990-10-01

    Recently, silent strokes are more frequently demonstrated by CT and MRI with the advance of neuroimaging. The infarcted lesions unrelated to the neurological symptoms were detected in 8, 30, 28, 34, 60, 63% of the patients with cerebral infarction in 1977-78, 1982, 1985, 1986, 1987, 1988, respectively, by CT and/or MRI, and the asymptomatic patients with incidentally diagnosed cerebral infarction were amounted to 16% (8 of 51 cases) in 1988. Of the recent 50 patients with cerebral infarction examined by CT and MRI, asymptomatic cerebrovascular lesions were detected in 25 (50%) by CT and in 35 (70%) by MRI. MRI also revealed asymptomatic old hemorrhage in 7 (14%). The clinical significance of silent stroke was discussed. (author).

  5. Scoring an Abstract Contemporary Silent Film

    OpenAIRE

    Frost, Crystal

    2014-01-01

    I composed an original digital audio film score with full sound design for a contemporary silent film called Apple Tree. The film is highly conceptual and interpretive and required a very involved, intricate score to successfully tell the story. In the process of scoring this film, I learned new ways to convey an array of contrasting emotions through music and sound. After analyzing the film's emotional journey, I determined that six defining emotions were the foundation on which to build an ...

  6. Teen Depression and Suicide, A SILENT CRISIS.

    Science.gov (United States)

    Kroning, Maureen; Kroning, Kayla

    2016-01-01

    Adolescent depression is a serious problem affecting 10.7% of all teens and 29.9% of high school students; 17% of high school students have contemplated suicide. Yet, depression in teens is often unrecognized. This article relays the tragic death of a 17-year-old, along with symptoms of depression and suicide in adolescents; DSM-5 criteria for depression; treatments including protective factors, psychotherapy, and medications; and imparts interventions for addressing this huge but silent crisis.

  7. Lipoperoxidación de membranas y daño ultraestructural por estrés oxidativo en isquemia-reperfusión miocárdica

    Directory of Open Access Journals (Sweden)

    José Milei

    2006-01-01

    Full Text Available Introducción En modelos experimentales, la formación de especies reactivas del oxígeno durante la reperfusión posisquémica induce “estrés oxidativo” que afecta al miocardio. Dado que los pacientes sometidos a cardioplejía sufren isquemia-reperfusión, se sugirió que en ellos habría estrés oxidativo. Sin embargo, este fenómeno aún no se ha caracterizado correctamente. Objetivo El propósito del presente trabajo fue correlacionar la liberación de glutatión (el paso inicial de estrés oxidativo con marcadores de progresión del daño oxidativo, como peroxidación de lípidos de membrana y desarrollo de alteraciones ultraestructurales. Material y métodos En 24 pacientes sometidos a cirugía de puente aortocoronario se investigaron cambios en varios marcadores de estrés oxidativo y daño tisular durante la reperfusión posisquémica. Se obtuvieron muestras de sangre y biopsias cardíacas basales y luego de la reperfusión a 40,9 ± 11,9 minutos de la cardioplejía. La liberación de glutatión basal fue insignificante (0,02 ± 0,04 µmol/L, pero aumentó a los 15 minutos de la reperfusión (1,10 ± 0,40 µmol/L; p < 0,05; también disminuyeron los niveles tisulares de ubiquinol, de 144,5 ± 52 a 97,6 ± 82 nmol/g (p < 0,05. Aunque estos cambios documentan el estrés oxidativo cardíaco, no hubo alteraciones bioquímicas indicativas de daño celular, ya que no se produjo un incremento de marcadores de peroxidación lipídica, tanto en sangre del seno coronario como en las biopsias cardíacas. Tampoco se observaron alteraciones ultraestructurales importantes. Conclusiones A pesar de observarse estrés oxidativo en pacientes sometidos a cirugía cardíaca, en las condiciones descriptas, no induce lesiones progresivas de membranas ni daño celular irreversible

  8. La concentración de mercado en el sector farmacéutico colombiano 2002-2003. Un análisis parcial para las enfermedades cerebrovasculares e isquemias, diabetes mellitus y morbimortalidad cardiovascular

    Directory of Open Access Journals (Sweden)

    Ismarlen Jiménez

    2005-10-01

    Full Text Available Este trabajo estudia la concentración de mercado del sector farmacéutico colombiano para diferentes grupos farmacológicos, teniendo en cuenta el índice de Hefindahl en los años 2002 y 2003. Metodológicamente, se parte de los indicadores de mortalidad para el año 2002, de donde se obtienen las principales causas de muerte para la población mayor de 45 años, esto es; enfermedades cerebrovasculares e isquemias, diabetes, enfermedades cardiovasculares y enfermedades crónicas de las vías respiratorias inferiores. Dichas patologías fueron atendidas con aproximadamente 507 medicamentos, comerciales y genéricos, por diferentes laboratorios de tipo nacional y multinacional. Como resultado importante se destaca que las patologías fueron atendidas por oligopolios fuertes en el año 2002, acentuando su posición para el año 2003.

  9. Neuroproteccióndel extracto hidroalcohólico de las hojas de Satureja brevicalyx ‘wayra muña’ en un modelo animal de hiperoxia e hipoxia-isquemia

    Directory of Open Access Journals (Sweden)

    Rody Arias-Rodríguez

    2012-07-01

    Full Text Available Objetivos: Evaluar el efecto neuroprotector del extracto hidroalcohólico de hojas de Satureja brevicalyx ‘wayra muña’ en ratas sometidas a hiperoxia, y su progenie sometidas a hipoxia isquemia. Diseño: Experimental. Lugar: Área de Cirugía Experimental, Instituto Nacional de Salud del Niño, y Laboratorios del Centro de Investigación de Bioquímica y Nutrición, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú. Material biológico: Rattus novegicus de la cepa Holtzman, hojas secas de Satureja brevicalyx ‘wayra muña’. Intervenciones: Tratamiento con el extracto en dos modelos: hiperoxia en ratas hembras adultas, e hipoxia en la progenie de ratas madre tratadas. Se realiza ANOVA y prueba de Tukey. Principales medidas de resultados: Actividad de superóxido dismutasa (SOD, niveles de glutatión (GSH total y niveles de sustancias reactivas al ácido tiobarbitúrico (TBARS. Resultados: En las ratas tratadas con el extracto se observó disminución significativa de TBARS y participación de GSH y SOD. Conclusiones: Nuestros resultados sugieren que el extracto hidroalcólico de Satureja brevicalyx ejerce efecto neuroprotector en condición de hiperoxia e hipoxia experimental, mediante la mitigación de la lipoperoxidación como parámetro de daño oxidativo, con participación del GSH y la actividad de SOD como mecanismos de defensa antioxidante.

  10. Recurrent Silent Thyroiditis as a Sequela of Postpartum Thyroiditis

    Science.gov (United States)

    Kim, Paul

    2014-01-01

    Thyroiditis encompasses a group of disorders characterized by thyroid inflammation. Though clinically indistinguishable from silent thyroiditis, postpartum thyroiditis occurs in women within 12 months after delivery. Recurrent postpartum thyroiditis in subsequent pregnancies is common, but recurrent silent thyroiditis is rare. We reported a case of patient with recurrent episodes of thyroiditis, unrelated to pregnancy, after an episode of postpartum thyroiditis. It is of interest that postpartum thyroiditis and silent thyroiditis could occur closely to each other; however, the link between these disorders is not well established. This report is to remind physicians of the possibility of recurrent silent thyroiditis in women with a history of postpartum thyroiditis. PMID:24987536

  11. Silent ischemia and beta-blockade

    DEFF Research Database (Denmark)

    Egstrup, K

    1991-01-01

    and should also be directed at the other coronary artery risk factors of the patients. The effects of beta-blockers, which reduce the duration and frequency of silent ischemic episodes, is well described. The effect is most pronounced in the morning, when the frequency of ischemia is highest......, and the mechanism of action seems mainly mediated through a reduction in myocardial oxygen demand. beta-Blockers have shown effectiveness in both effort-induced angina and mixed angina, and increased anti-ischemic potency may be achieved by combination therapy with a calcium antagonist. Abrupt withdrawal of beta-blockers...

  12. An introduction to silent speech interfaces

    CERN Document Server

    Freitas, João; Dias, Miguel Sales; Silva, Samuel

    2017-01-01

    This book provides a broad and comprehensive overview of the existing technical approaches in the area of silent speech interfaces (SSI), both in theory and in application. Each technique is described in the context of the human speech production process, allowing the reader to clearly understand the principles behind SSI in general and across different methods. Additionally, the book explores the combined use of different data sources, collected from various sensors, in order to tackle the limitations of simpler SSI approaches, addressing current challenges of this field. The book also provides information about existing SSI applications, resources and a simple tutorial on how to build an SSI.

  13. Eye Movement during Silent and Oral Reading: How Can we Compensate the Loss of Multisensory Process during Silent Reading?

    Directory of Open Access Journals (Sweden)

    Maiko Takahashi

    2011-10-01

    Full Text Available While reading texts orally, we process the multisensory language information. Accordingly, in the context of reading aloud, we process the visually presented text and produce the auditory information of the text through articulatory movement. These multisensory processing activities are assumed to facilitate the memory and comprehension of textual information. Conversely, while reading silently, we process only the visual information of the text. Although we cannot use the multisensory language information while reading silently, several researchers have found that there is little difference between the degree of comprehension based on silent and oral reading for adult readers. The purpose of this study is to explain how we compensate the loss of multisensory process during silent reading by comparing the visual processing process during silent and oral reading. By conducting two experiments, we measured and compared the eye movement during silent and oral reading. The results showed that silent reading took shorter time for comprehension than oral reading, and readers had more visual fixation points and read back frequently during reading silently than orally. These reading strategies during silent reading seemed to compensate the loss of multisensory process and support the text comprehension.

  14. Silent Bodies: Japanese taciturnity and image thinking

    Directory of Open Access Journals (Sweden)

    Ana Došen

    2017-03-01

    Full Text Available A nonverbal transmission and an implicit way of communication are highly encouraged in Japanese society. The reason for this “silence prerogative” is often found in historical facts of lengthy feudal era or in ancient philosophies and religions such as Buddhism and Confucianism and their various concepts which privilege taciturn way of communication. Moreover, the unspoken comprehension is often complemented by the attitude which equates truthfulness with silence. This paper explores the silence as a communicative act in the domain of Japanese art, where the body takes over the place of the language. In traditional Japanese theatrical performance, such as noh, words are often inadequate to convey emotion and therefore the aesthetics of emptiness, understatement and abstraction is transcended by the masks with "nonmoving lips". Drawing on theoretical perspectives from both East and West, I argue that the silent bodies operate as deliberate and integral determinants of Japanese non-silent art forms – especially in cinema and theatre. In the Eastern thought, visual perception is fundamental in cognition of the world, whereas auditory discernment is secondary to "image-thinking" (Yuasa. Accustomed to taciturnity, Japanese audience effectively corresponds to the performance and "completes" it in silence.

  15. Silent Conversations in the Labyrinth of Artistic Research and Practice

    Science.gov (United States)

    Eis, Andrea

    2013-01-01

    This essay explores silent conversations with the past, but also navigates through the labyrinth of artistic process, with its manifold passages of research, chance occurrence and aesthetic experimentation. The double metaphors of silent conversations and labyrinths apply to the essay and the artwork within it, to the research and to the practice.…

  16. Silent Localization of Underwater Sensors Using Magnetometers

    Directory of Open Access Journals (Sweden)

    Jonas Callmer

    2010-01-01

    Full Text Available Sensor localization is a central problem for sensor networks. If the sensor positions are uncertain, the target tracking ability of the sensor network is reduced. Sensor localization in underwater environments is traditionally addressed using acoustic range measurements involving known anchor or surface nodes. We explore the usage of triaxial magnetometers and a friendly vessel with known magnetic dipole to silently localize the sensors. The ferromagnetic field created by the dipole is measured by the magnetometers and is used to localize the sensors. The trajectory of the vessel and the sensor positions are estimated simultaneously using an Extended Kalman Filter (EKF. Simulations show that the sensors can be accurately positioned using magnetometers.

  17. ESTUDIO COMPARATIVO DEL EFECTO DE CRANEO-ACUPUNTURA VS ACUPUNTURA CORPORAL, EN PACIENTES CON SECUELAS DE ENFERMEDAD VASCULAR CEREBRAL EN EL HOSPITAL REGIONAL DEL INSTITUTO DE SEGURIDAD SOCIAL AL SERVICIO DE LOS TRABAJADORES DEL ESTADO DE PUEBLA

    OpenAIRE

    MENDEZ MENDEZ, NAZARIO CELSO

    2011-01-01

    ESTUDIO COMPARATIVO DEL EFECTO DE LA CRANEOACUPUNTURA VS ACUPUNTURA CORPORAL, EN PACIENTES CON SECUELAS DE ENFERMEDAD VASCULAR CEREBRAL EN EL HOSPITAL REGIONAL DEL INSTITUTO DE SEGURIDAD SOCIAL AL SERVICIO DE LOS TRABAJADORES DEL ESTADO DE PUEBLA. LAS SECUELAS DE EVC SON UN PROBLEMA DE SALUD PUBLICA, CON MAYOR FRECUENCIA DE LA ISQUEMIA 81.25 POR CIENTO POR CIENTO Y EN SEGUNDO LUGAR LA HEMORRÁGICA CON EL 18.75 POR CIENTO, EL SEXO FEMENINO ES LA MAS FRECUENTE Y LA EDAD MAS AFECTADA ES DE LO...

  18. Modification of hormonal secretion in clinically silent pituitary adenomas.

    Science.gov (United States)

    Daems, Tania; Verhelst, Johan; Michotte, Alex; Abrams, Pascale; De Ridder, Dirk; Abs, Roger

    2009-01-01

    Silent pituitary adenomas are a subtype of adenomas characterized by positive immunoreactivity for one or more hormones classically secreted by normal pituitary cells but without clinical expression, although in some occasions enhanced or changed secretory activity can develop over time. Silent corticotroph adenomas are the classical example of this phenomenon. A series of about 500 pituitary adenomas seen over a period of 20 years were screened for modification in hormonal secretion. Biochemical and immunohistochemical data were reviewed. Two cases were retrieved, one silent somatotroph adenoma and one thyrotroph adenoma, both without specific clinical features or biochemical abnormalities, which presented 20 years after initial surgery with evidence of acromegaly and hyperthyroidism, respectively. While the acromegaly was controlled by a combination of somatostatin analogs and growth hormone (GH) receptor antagonist therapy, neurosurgery was necessary to manage the thyrotroph adenoma. Immunohistochemical examination demonstrated an increase in the number of thyroid stimulating hormone (TSH)-immunoreactive cells compared to the first tissue. Apparently, the mechanisms responsible for the secretory modifications are different, being a change in secretory capacity in the silent somatotroph adenoma and a quantitative change in the silent thyrotroph adenoma. These two cases, one somatotroph and one thyrotroph adenoma, are an illustration that clinically silent pituitary adenomas may in rare circumstances evolve over time and become active, as previously demonstrated in silent corticotroph adenomas.

  19. Tratamento da isquemia mesentérica pelo pós-condicionamento isquêmico Mesenteric ischemia's treatment by postconditioning

    Directory of Open Access Journals (Sweden)

    Carlos Henrique Marques dos Santos

    2008-06-01

    Full Text Available Sabe-se que o pré-condicionamento isquêmico tem a capacidade de minimizar as lesões decorrentes do processo de isquemia e reperfusão. Recentemente foi descrito que o pós-condicionamento isquêmico apresenta resultados semelhantes em isquemia e reperfusão miocárdica, cerebral, renal e da medula espinhal, mas não há relatos de utilização deste método na isquemia mesentérica. OBJETIVO: O objetivo deste estudo é avaliar o efeito do pós-condicionamento isquêmico sobre a lesão tecidual na mucosa intestinal de ratos submetidos ao processo de isquemia e reperfusão mesentérica. MÉTODO: Foram estudados 20 ratos Wistar, distribuídos em dois grupos: grupo A, em que se realizou isquemia (30 minutos e reperfusão (60 minutos mesentérica; grupo B, isquemia e reperfusão mesentérica e, precedendo o início da reperfusão, foi realizado o pós-condicionamento isquêmico. Ao final, ressecou-se um segmento do intestino delgado para análise histológica. Avaliaram-se os resultados pela classificação de Chiu e procedeu-se o tratamento estatístico. RESULTADO: As médias dos graus de lesão tecidual foram: grupo A, 3,5; grupo B, 1. A diferença entre os grupos foi considerada estatisticamente significativa (p It is known that the preconditioning has the capacity to minimize the current lesions of the ischemia and reperfusion process. Recently it was described that the postconditioning presents similar results in miocardic ischemia and reperfusion, brain, kidneys and of the spinal cord, but there are no reports of use of this method in the mesenteric ischemia. OBJECTIVE: The objective of this study is to evaluate the effect of the postconditioning on the tissue lesion in the intestinal mucosa of rats submitted to the ischemia and reperfusion process. METHOD: 20 Wistar rats were studied, distributed in two groups: group A, in that was done mesenteric ischemia (30 minutes and reperfusion (60 minutes; group B, mesenteric ischemia and reperfusion

  20. Efeitos do alopurinol sobre a lipoperoxidação de membranas celulares renais na síndrome da isquemia e reperfusão: estudo experimental em ratos

    Directory of Open Access Journals (Sweden)

    Rhoden Ernani Luís

    1998-01-01

    Full Text Available Objetivo: Vários estudos têm demonstrado que Radicais Livres de Oxigênio (RLO contribuem para o dano celular decorrente da isquemia e reperfusão. Este estudo foi desenvolvido como o objetivo de avaliar os efeitos da isquemia e reperfusão renal em ratos, tratados ou não com alopurinol, sobre a lipoperoxidação (LPO das membranas celulares renais. Método: Foram usados ratos Wistar distribuídos em 4 grupos e submetidos a períodos de isquemia e reperfusão renal ou não, dependendo do grupo. Também foram submetidos ou não a tratamento com alopurinol na dose de 50 e 150 mg/Kg por via intraperitoneal, 5 e 1 horas antes do procedimento. Na avaliação da lipoperoxidação utilizou-se os métodos do TBARS e QL. Resultados: Os resultados demonstraram aumento da LPO nos animais submetidos a isquemia e reperfusão renal. No entanto, estes efeitos deletérios foram reduzidos com o pré-tratamento com alopurinol (p<0,05. Conclusão: O dano causado em animais submetidos a isquemia e reperfusão renal pode ser demonstrado e quantificado pela LPO. Além disso, o alopurinol demonstrou proteção renal contra o dano decorrente desta síndrome, diminuindo a LPO nestes animais. Estes resultados sugerem que a via da xantina oxidase é uma das mais importantes rotas metabólicas envolvidas na geração de RLO, estes responsáveis em parte pelos danos funcionais do rim na síndrome da isquemia e reperfusão deste órgão.

  1. Monstruos de la Universal: la etapa silente y los mitos del sonoro

    Directory of Open Access Journals (Sweden)

    David Fuentefría-Rodríguez

    2013-04-01

    Full Text Available En coincidencia con el centenario en 2012 de los legendarios Estudios Universal, este trabajo propone un exhaustivo análisis crítico sobre la construcción de sus principales símbolos terroríficos, la mayoría inspirados en la literatura, que entre los años 1923 y 1941 conformaron la estructura mitogénica del denominado “monstruo clásico”. Tanto en la etapa silente, como con la irrupción del sonoro, las películas de terror de la Universal marcaron un paso imprescindible en la evolución de este género canónico, y a ellas se debe buena parte del ingente desarrollo posterior del mismo.In coincidence with 2012 legendary Universal Studio´s centenary, this paper proposes an exhaustive critical analysis on the construction of its principal terrifying symbols, the majority inspired by literature, which between 1923 and 1941 shaped the myth structure of the so-called "classic monster". In both stages, silent and sonorous movies, the terror of Universal Studios marked an indispensable step in the evolution of this canonical genre, and to them it is owed a good deal of its enormous later development.

  2. Isquemia cerebral focal transitoria en rata: caracterización y utilidad del modelo de la sutura intraluminal en el estudio de estrategias neuroprotectoras

    OpenAIRE

    Pérez Asensio, Fernando Jesús

    2005-01-01

    RESUMEN Los accidentes cerebrovasculares agudos (ictus cerebrales) son trastornos neurológicos originados por la disminución brusca del aporte sanguíneo cerebral (isquemia cerebral). La incidencia del ictus en España es de unos 200 casos por cada 100.000 habitantes, lo que le sitúa como la segunda causa de muerte, la primera de invalidez permanente y segunda de demencia. A excepción de la aplicación de la terapia trombolítica, actualmente no existe otro tratamiento eficaz del ictus en c...

  3. Estudo da isquemia e reperfusão em retalhos cutâneos de ratos The study of the ischemia and reperfusion in skin flaps of rats

    Directory of Open Access Journals (Sweden)

    Frederico Alonso Sabino de Freitas

    2002-01-01

    Full Text Available INTRODUÇÃO: Múltiplos fatores têm sido implicados na patogênese da lesão de isquemia/reperfusão da pele, incluindo as espécies reativas de oxigênio. OBJETIVO: Estudar a lesão de isquemia/reperfusão em retalhos cutâneos de ratos avaliando os níveis teciduais do malonildialdeído (MDA e xantina oxidase (XO. MÉTODOS: Foram utilizados 8 ratos Wistar, com peso entre 300 - 400g, sendo confeccionados 2 retalhos epigástricos por animal (controle e experimento, um deles submetido à 16h de isquemia (RI seguida de 45 min de reperfusão (RR e o outro controle (RC. Foram colhidas 3 biópsias de pele dos retalhos (RC, RI, RR e encaminhadas para dosagem de MDA e XO. RESULTADOS: A análise bioquímica mostrou aumento significativo dos níveis teciduais de MDA e XO após a reperfusão em relação aos retalhos controles. CONCLUSÃO: Retalhos epigástricos de ratos submetidos à 16h de isquemia e 45min de reperfusão apresentam elevação dos níveis teciduais de MDA e XO, caracterizando a lipoperoxidação da membrana celular.INTRODUCTION: Multiple factors have been implicated in the pathogenesis of reperfusion injury in the skin, including the reactive oxygen species. OBJECTIVE: The aim was to evaluate the effect of reperfusion injury in the rat skin flap evaluated by tissue assay for malonyldialdehyde (MDA and xanthine oxidase (XO. METHODS: 8 Wistar rats were used, between 300-400g weight and two identical epigastric flaps were raised in each animal (control and experiment, the vasculature of one flap was left intact and in the second flap the arterial pedicle was clamped for 16 hours and reperfused for 45 minutes. Skin samples were obtained from each flap after these periods of time and submitted to MDA and XO analysis. RESULTS: Reperfused flaps had significantly increased MDA and XO values compared to the control flaps biopsies. CONCLUSION: The lipid peroxidation levels were higher in the rat epigastric skin flaps subjected to 16 hours of

  4. Using Vocal and Silent Reading Approaches for the Enhancement ...

    African Journals Online (AJOL)

    Nekky Umera

    An International Multi-Disciplinary Journal. Vol. 3 (1) ... expresses his thoughts and feelings in such a way that the person can be ... creative, critical and evaluative. .... In the first week, the research assistants taught the oral and silent reading.

  5. Silent store detection and recording in memory storage

    Energy Technology Data Exchange (ETDEWEB)

    Bose, Pradip; Cher, Chen-Yong; Nair, Ravi

    2017-03-14

    An aspect includes receiving a write request that includes a memory address and write data. Stored data is read from a memory location at the memory address. Based on determining that the memory location was not previously modified, the stored data is compared to the write data. Based on the stored data matching the write data, the write request is completed without writing the write data to the memory and a corresponding silent store bit, in a silent store bitmap is set. Based on the stored data not matching the write data, the write data is written to the memory location, the silent store bit is reset and a corresponding modified bit is set. At least one of an application and an operating system is provided access to the silent store bitmap.

  6. Silent store detection and recording in memory storage

    Energy Technology Data Exchange (ETDEWEB)

    Bose, Pradip; Cher, Chen-Yong; Nair, Ravi

    2017-03-07

    An aspect includes receiving a write request that includes a memory address and write data. Stored data is read from a memory location at the memory address. Based on determining that the memory location was not previously modified, the stored data is compared to the write data. Based on the stored data matching the write data, the write request is completed without writing the write data to the memory and a corresponding silent store bit, in a silent store bitmap is set. Based on the stored data not matching the write data, the write data is written to the memory location, the silent store bit is reset and a corresponding modified bit is set. At least one of an application and an operating system is provided access to the silent store bitmap.

  7. Silent Circulation of Ross River Virus in French Polynesia

    Directory of Open Access Journals (Sweden)

    Maite Aubry

    2015-08-01

    Discussion: Our results support the existence of autochthonous RRV transmission and suggest that this pathogen has silently circulated in French Polynesia. These findings raise the question of possible undetected circulation of RRV in other Pacific Island Countries and Territories.

  8. Current practice for diagnosis and management of silent atrial fibrillation

    DEFF Research Database (Denmark)

    Dobreanu, Dan; Svendsen, Jesper Hastrup; Lewalter, Thorsten

    2013-01-01

    for the diagnosis and management of silent AF. This survey is based on an electronic questionnaire sent to the European Heart Rhythm Association Research Network partners. Responses were received from 33 centres in 16 countries. The preferred screening methods for silent AF in patients with rhythm control...... for such patients. Most responders preferred rate control over rhythm control in patients with silent AF, although some favoured pulmonary vein isolation in young patients. However, oral anticoagulant therapy in patients at high thromboembolic risk was considered mandatory by most, provided that at least one......Although it is well known that silent atrial fibrillation (AF) is associated with morbidity and mortality rates similar to those of symptomatic AF, no specific strategy for screening and management of this form of AF has been advocated. The purpose of this survey was to identify current practices...

  9. Multiple Silent Lacunes Are Associated with Recurrent Ischemic Stroke

    DEFF Research Database (Denmark)

    Andersen, Søren Due; Skjøth, Flemming; Yavarian, Yousef

    2016-01-01

    ackground: Silent lacunes are a common finding on brain imaging in ischemic stroke patients, but the prognostic significance of these lesions is uncertain. We aimed at investigating the association of silent lacunes and the risk of ischemic stroke recurrence, death, and cardiovascular events...... in a cohort of patients with incident ischemic stroke and no atrial fibrillation (AF). Methods: We included 786 patients (mean age 59.5 (SD 14.0); 42.9% females) in a registry-based, observational cohort study on patients with first-ever ischemic stroke. On brain MRI we assessed the number of silent lacunes...... as none, single, or multiple and we calculated stratified incidence rates of the outcomes. Cox proportional hazard ratios (HRs) adjusted for age, gender, congestive heart failure, hypertension, diabetes, and vascular disease were calculated with no silent lacunes as reference. In additional analyses, we...

  10. Silent Synapse-Based Circuitry Remodeling in Drug Addiction.

    Science.gov (United States)

    Dong, Yan

    2016-05-01

    Exposure to cocaine, and likely other drugs of abuse, generates α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-silent glutamatergic synapses in the nucleus accumbens. These immature synaptic contacts evolve after drug withdrawal to redefine the neurocircuital properties. These results raise at least three critical questions: (1) what are the molecular and cellular mechanisms that mediate drug-induced generation of silent synapses; (2) how are neurocircuits remodeled upon generation and evolution of drug-generated silent synapses; and (3) what behavioral consequences are produced by silent synapse-based circuitry remodeling? This short review analyzes related experimental results, and extends them to some speculations. © The Author 2015. Published by Oxford University Press on behalf of CINP.

  11. How Silent is the Right to Silence?

    Directory of Open Access Journals (Sweden)

    Katherine Biber

    2012-11-01

    Full Text Available A long-held and fundamental principle of our criminal justice system is that people accused of crimes have a right to silence, arising from the presumption of innocence. Rules of evidence try to protect this ‘right’ during trial, by ensuring that juries understand that adverse inferences cannot be drawn from the silence of the accused. Silence, in court, can mean nothing, and we are not to speculate about what might motivate an accused person to remain silent, or what they might have said had they spoken. However, an examination of the jurisprudence in this area shows that the law is often not dealing with actual silence; sometimes when the law refers to the ‘right to silence’, it seems to mean a ‘refusal to hear’. In other instances, there is actual silence, and yet the law refuses to subject that silence to any critical interpretation, insisting that we cannot infer anything from it. While we have learned, from theatre, music, linguistics, religion and psychology, to develop sophisticated means for interpreting silence, the law demands that we set aside these interpretive tools, hearing silence that isn’t there, and inferring nothing about something.

  12. Silent communication: toward using brain signals.

    Science.gov (United States)

    Pei, Xiaomei; Hill, Jeremy; Schalk, Gerwin

    2012-01-01

    From the 1980s movie Firefox to the more recent Avatar, popular science fiction has speculated about the possibility of a persons thoughts being read directly from his or her brain. Such braincomputer interfaces (BCIs) might allow people who are paralyzed to communicate with and control their environment, and there might also be applications in military situations wherever silent user-to-user communication is desirable. Previous studies have shown that BCI systems can use brain signals related to movements and movement imagery or attention-based character selection. Although these systems have successfully demonstrated the possibility to control devices using brain function, directly inferring which word a person intends to communicate has been elusive. A BCI using imagined speech might provide such a practical, intuitive device. Toward this goal, our studies to date addressed two scientific questions: (1) Can brain signals accurately characterize different aspects of speech? (2) Is it possible to predict spoken or imagined words or their components using brain signals?

  13. Silent synapses in neuromuscular junction development.

    Science.gov (United States)

    Tomàs, Josep; Santafé, Manel M; Lanuza, Maria A; García, Neus; Besalduch, Nuria; Tomàs, Marta

    2011-01-01

    In the last few years, evidence has been found to suggest that some synaptic contacts become silent but can be functionally recruited before they completely retract during postnatal synapse elimination in muscle. The physiological mechanism of developmental synapse elimination may be better understood by studying this synapse recruitment. This Mini-Review collects previously published data and new results to propose a molecular mechanism for axonal disconnection. The mechanism is based on protein kinase C (PKC)-dependent inhibition of acetylcholine (ACh) release. PKC activity may be stimulated by a methoctramine-sensitive M2-type muscarinic receptor and by calcium inflow though P/Q- and L-type voltage-dependent calcium channels. In addition, tropomyosin-related tyrosine kinase B (trkB) receptor-mediated brain-derived neurotrophic factor (BDNF) activity may oppose the PKC-mediated ACh release depression. Thus, a balance between trkB and muscarinic pathways may contribute to the final functional suppression of some neuromuscular synapses during development. © 2010 Wiley-Liss, Inc.

  14. Usefulness of percutaneous transluminal coronary angioplasty in silent myocardial ischemia

    International Nuclear Information System (INIS)

    Hou, Mami

    1996-01-01

    The usefulness of percutaneous transluminal coronary angioplasty (PTCA) was assessed in patients with exercise-induced asymptomatic myocardial ischemia (silent ischemia) and compared with exercise-induced symptomatic myocardial ischemia (symptomatic ischemia). Patients with single vessel coronary artery disease (51 with angina pectoris, 40 with old myocardial infarction) and evidence of stress-induced ischemia on thallium-201 single photon emission computed tomography (SPECT) underwent successful PTCA. Thirty-seven percent of angina patients and 60% of infarction patients showed asymptomatic exercise-induced ischemia. There was no significant difference in population characteristics between silent and symptomatic patients. Patients with silent angina had significantly higher percentage thallium uptake and washout rate than symptomatic patients. After PTCA, both percentage diameter stenosis and percentage thallium uptake were improved in all patients with angina irrespective of the presence or absence of symptoms. There were no significant differences in percentage thallium uptake and washout rate between patients with silent and symptomatic infarction. After PTCA, percentage diameter stenosis, percentage thallium uptake, and washout rate improved in all infarction patients irrespective of the symptoms. Zero percent of silent angina patients, 12% of symptomatic angina patients, 12% of silent infarction patients, 19% of symptomatic infarction patients had cardiac events during about 4.5 years after PTCA. The incidence of cardiac events did not significantly differ in any patient group. PTCA improved myocardial perfusion in all patients, and the incidence of cardiac events did not differ between the silent and symptomatic groups. Revascularization with PTCA is suitable for patients with silent as well as symptomatic ischemia. (author)

  15. Recurrent Silent Thyroiditis as a Sequela of Postpartum Thyroiditis

    OpenAIRE

    Hanseree, Preaw; Salvador, Vincent Bryan; Sachmechi, Issac; Kim, Paul

    2014-01-01

    Thyroiditis encompasses a group of disorders characterized by thyroid inflammation. Though clinically indistinguishable from silent thyroiditis, postpartum thyroiditis occurs in women within 12 months after delivery. Recurrent postpartum thyroiditis in subsequent pregnancies is common, but recurrent silent thyroiditis is rare. We reported a case of patient with recurrent episodes of thyroiditis, unrelated to pregnancy, after an episode of postpartum thyroiditis. It is of interest that postpar...

  16. Evidence for presynaptically silent synapses in the immature hippocampus

    International Nuclear Information System (INIS)

    Yoon, Jae Young; Choi, Sukwoo

    2017-01-01

    Silent synapses show NMDA receptor (NMDAR)-mediated synaptic responses, but not AMPAR-mediated synaptic responses. A prevailing hypothesis states that silent synapses contain NMDARs, but not AMPARs. However, alternative presynaptic hypotheses, according to which AMPARs are present at silent synapses, have been proposed; silent synapses show slow glutamate release via a fusion pore, and glutamate spillover from the neighboring synaptic terminals. Consistent with these presynaptic hypotheses, the peak glutamate concentrations at silent synapses have been estimated to be ≪170 μM, much lower than those seen at functional synapses. Glutamate transients predicted based on the two presynaptic mechanisms have been shown to activate only high-affinity NMDARs, but not low-affinity AMPARs. Interestingly, a previous study has developed a new approach to distinguish between the two presynaptic mechanisms using dextran, an inert macromolecule that reduces the diffusivity of released glutamate: postsynaptic responses through the fusion pore mechanism, but not through the spillover mechanism, are potentiated by reduced glutamate diffusivity. Therefore, we reasoned that if the fusion pore mechanism underlies silent synapses, dextran application would reveal AMPAR-mediated synaptic responses at silent synapses. In the present study, we recorded AMPAR-mediated synaptic responses at the CA3-CA1 synapses in neonatal rats in the presence of blockers for NMDARs and GABAARs. Bath application of dextran revealed synaptic responses at silent synapses. GYKI53655, a selective AMPAR-antagonist, completely inhibited the unsilenced synaptic responses, indicating that the unsilenced synaptic responses are mediated by AMPARs. The dextran-mediated reduction in glutamate diffusivity would also lead to the activation of metabotropic glutamate receptors (mGluRs), which might induce unsilencing via the activation of unknown intracellular signaling. Hence, we determined whether mGluR-blockers alter

  17. La combinación de atorvastatina y meloxicam inhibe la neuroinflamación y atenúa el daño celular en la isquemia cerebral experimental por embolia arterial

    Directory of Open Access Journals (Sweden)

    Lina María De los Reyes

    2014-09-01

    Conclusión. La combinación de meloxicam y atorvastatina atenúa la respuesta de los astrocitos y la microglia en el proceso inflamatorio posterior a la isquemia cerebral por embolia arterial, reduciendo la degeneración neuronal y restableciendo el equilibrio morfológico y funcional del tejido nervioso.

  18. Influencia del perfil clínico del donante, receptor y tiempo de isquemia en la supervivencia del trasplante cardíaco. Subanálisis del Registro Español de Trasplante Cardíaco

    Directory of Open Access Journals (Sweden)

    María J. Paniagua

    2015-11-01

    Conclusiones: Muchas características del donante y el receptor, así como el tiempo de isquemia, influyen en la supervivencia del TC. El acúmulo de variables consideradas no óptimas repercutirá negativamente y de forma significativa en la supervivencia del TC.

  19. Avaliação bioquímica dos efeitos do pré-condicionamento isquêmico após isquemia e reperfusão hepática em ratos

    Directory of Open Access Journals (Sweden)

    Fábio Neves da Silva

    Full Text Available OBJETIVO: Comparar a lesão hepatocelular ocasionada pelo emprego do pré-condicionamento isquêmico e de duas outras modalidades de clampeamento tríade portal: clampeamento contínuo e intermitente. MÉTODO: Quarenta ratos Wistar foram divididos em quatro grupos de 10 animais cada. No Grupo Sham nenhuma espécie de clampeamento foi adotada. Nos outros três, provocamos isquemia de quarenta minutos por meio do clampeamento do pedículo hepático. No Grupo I esta isquemia foi contínua. No Grupo II, também contínua, mas precedida de cinco minutos de isquemia e 10 minutos de reperfusão (précondicionamento isquêmico. No Grupo III foi realizada isquemia intermitente em ciclos de 10 min de isquemia e cinco minutos de reperfusão. Para avaliar a lesão hepatocelular foi adotada a dosagem de transaminase glutâmico oxalacética (TGO, glutâmico pirúvica (TGP e lactato desidrogenase (LDH, aferidas no início e no final dos procedimentos. RESULTADOS: Não houve diferença estatística nos valores basais das enzimas estudadas, demonstrando uniformidade nos grupos. Os quatro grupos apresentaram variação significativa de todas as enzimas entre os dois momentos de coleta, porém de forma diferenciada. A variação no Grupo Sham foi menor que a do grupo II. Este foi semelhante ao grupo III e em todos a elevação foi significativamente menor que no grupo I (D do Sham CONCLUSÕES: Em ratos Wistar o clampeamento contínuo do pedículo hepático, precedido de um ciclo de cinco minutos de isquemia e 10 minutos de reperfusão (pré-condicionamento isquêmico provoca menor lesão hepática do que o clampeamento contínuo e apresenta resultados comparáveis aos obtidos através da utilização do clampeamento intermitente, em fígados normais submetidos a um período de isquemia hepática de 40 minutos e um tempo total de cirurgia de 60 minutos.

  20. Replacing dark energy by silent virialisation

    Science.gov (United States)

    Roukema, Boudewijn F.

    2018-02-01

    Context. Standard cosmological N-body simulations have background scale factor evolution that is decoupled from non-linear structure formation. Prior to gravitational collapse, kinematical backreaction (𝒬𝒟) justifies this approach in a Newtonian context. Aims: However, the final stages of a gravitational collapse event are sudden; a globally imposed smooth expansion rate forces at least one expanding region to suddenly and instantaneously decelerate in compensation for the virialisation event. This is relativistically unrealistic. A more conservative hypothesis is to allow non-collapsed domains to continue their volume evolution according to the 𝒬𝒟 Zel'dovich approximation (QZA). We aim to study the inferred average expansion under this "silent" virialisation hypothesis. Methods: We set standard (MPGRAFIC) EdS 3-torus (T3) cosmological N-body initial conditions. Using RAMSES, we partitioned the volume into domains and called the DTFE library to estimate the per-domain initial values of the three invariants of the extrinsic curvature tensor that determine the QZA. We integrated the Raychaudhuri equation in each domain using the INHOMOG library, and adopted the stable clustering hypothesis to represent virialisation (VQZA). We spatially averaged to obtain the effective global scale factor. We adopted an early-epoch-normalised EdS reference-model Hubble constant H1EdS = 37.7 km s-1 /Mpc and an effective Hubble constant Heff,0 = 67.7 km s-1 /Mpc. Results: From 2000 simulations at resolution 2563, we find that reaching a unity effective scale factor at 13.8 Gyr (16% above EdS), occurs for an averaging scale of L13.813 = 2.5-0.1+0.1 Mpc/heff. Relativistically interpreted, this corresponds to strong average negative curvature evolution, with the mean (median) curvature functional Ωℛ𝒟 growing from zero to about 1.5-2 by the present. Over 100 realisations, the virialisation fraction and super-EdS expansion correlate strongly at

  1. Silent Revolution in Research for Sustainability

    Directory of Open Access Journals (Sweden)

    Bruce Alder

    2016-06-01

    Full Text Available Is research ‘fit-for-purpose’ for realizing sustainable development? More than two decades after the Brundtland report and UNCED Earth summit, the world has now adopted Sustainable Development Goals(SDGs. Rather than a cause for celebration, this delay should encourage reflection on the role of research in society. Why is it so difficult to realize sustainability in practice? The answer lies in the fact that universities and research centres persist with 19th century methods of data gathering, scholarly analysis, and journal articles. Today’s world needs science in real-time, whether to detect drought, confront Ebola, or assist refugees. Research needs to work faster and embrace 21st century practices including data science, open access, and infographics.A silent revolution is occurring in the ways of organizing and conducting research, enabled by new technology and encouraging work that tackles the key challenges facing society. A variety of new arrangements have come into existence that promote international collaboration, including Horizon 2020 with its emphasis on societal challenges, the Bill & Melinda Gates Foundation which has inspired a family of grand challenges funds on health and development, and the Future Earth joint program of research for global sustainability. These arrangements not only control billions of dollars in research funding, they also influence the strategies of national research councils and international organizations. The result is no less than a transformation in the incentives that reward how researchers invest their time and effort.Why is a revolution needed? Within research, substantial growth in knowledge production coincided with fragmentation among disciplines. One can easily find expertise and publications in soil science or agronomy, yet integrated efforts on food security and climate adaptation remain scarce. Beyond research, society remains largely uninformed, as academics avoid engaging in public

  2. COMPORTAMIENTO ANTIARRÍTMICO DE LA HIPOXIA EN SIMULACIONES DE PARED TRANSMURAL CARDÍACA EN PRESENCIA DE ISQUEMIA SUB-EPICÁRDICA

    Directory of Open Access Journals (Sweden)

    Oscar Henao Gallo

    2011-01-01

    Full Text Available

    RESUMEN 

    El papel preponderante de la corriente de potasio sensitiva a Adenosin Trifosfato y su contribución a cambios electrofi siológicos que ocurren durante heterogeneidades y alteraciones fisicoquímicas debido a isquemia en la pared transmural cardíaca son aún debatidos. El objetivo de este trabajo fue estudiar la infl uencia de la activación de la hipoxia en la desestabilización del frente de onda eléctrico en pared transmural heterogénea en presencia de isquemia subepicárdica en un modelo computacional de tejido virtual. La taquicardia polimórfi ca obtenida de las simulaciones muestra que la activación de la hipoxia presenta un comportamiento antiarrítmico. La hiperkalemia es el principal agente capaz de generar bloqueo de conducción y alteraciones del segmento TQ y el segmento ST en los electrogramas obtenidos.

     

    Palabras clave: Electrogramas, hipoxia, isquemia, modelo Luo-Rudy, pared transmural heterogénea, reentrada espiral, taquicardia ventricular polimórfica.

     

    ABSTRACT

     

    ANTIARRHYTHMIC BEHAVIOR OF HYPOXIA IN CARDIAC TRANSMURAL WALL SIMULATIONS IN PRESENCE OF SUB-EPICARDIC ISCHEMIA

    The role of potassium adenosine triphosphate sensitive fl ow and its contributions to electrophysiological changes that occur during chemical-physical alterations and heterogeneities due to ischemia in cardiac transmural wall is still debated.

     

    The aim of this work was to study hypoxia activation influence in wavefront electric disturbance in heterogeneous transmural wall subjected to sub-epicardial ischemia, using a virtual tissue computational model. Polymorphic tachycardia obtained

  3. Silent (painless) thyroiditis. Evidence of a geographic variation in frequency

    International Nuclear Information System (INIS)

    Vitug, A.C.; Goldman, J.M.

    1985-01-01

    Recent reports suggest that 14% to 23% of thyrotoxic patients have silent (painless) thyroiditis, a newly described syndrome characterized by transient thyrotoxicosis with a low radioactive iodine uptake. A three-year review at a Brooklyn (NY) hospital showed only one definite and three possible cases of silent thyroiditis among 86 thyrotoxic patients. At most, 4% to 5% of thyrotoxic patients had silent thyroiditis. The authors suggest a geographic variation in this syndrome. Most cases and the largest series are from Japan and the Great Lakes area of North America. The latter may be related to increased iodine intake over many years in a previously endemic area of hypoiodidism and goiter, although other local factors may also be involved

  4. Silent (painless) thyroiditis. Evidence of a geographic variation in frequency

    Energy Technology Data Exchange (ETDEWEB)

    Vitug, A.C.; Goldman, J.M.

    1985-03-01

    Recent reports suggest that 14% to 23% of thyrotoxic patients have silent (painless) thyroiditis, a newly described syndrome characterized by transient thyrotoxicosis with a low radioactive iodine uptake. A three-year review at a Brooklyn (NY) hospital showed only one definite and three possible cases of silent thyroiditis among 86 thyrotoxic patients. At most, 4% to 5% of thyrotoxic patients had silent thyroiditis. The authors suggest a geographic variation in this syndrome. Most cases and the largest series are from Japan and the Great Lakes area of North America. The latter may be related to increased iodine intake over many years in a previously endemic area of hypoiodidism and goiter, although other local factors may also be involved.

  5. Silent method for mathematics instruction: An overview of teaching subsets

    Science.gov (United States)

    Sugiman, Apino, Ezi

    2017-05-01

    Generally, teachers use oral communication for teaching mathematics. Taking an opposite perspective, this paper describes how instructional practices for mathematics can be carried out namely a silent method. Silent method uses body language, written, and oral communication for classroom interaction. This research uses a design research approach consisting of four phases: preliminary, prototyping and developing the instruction, and assessment. There are four stages of silent method. The first stage is conditioning stage in which the teacher introduces the method and makes agreement about the `rule of the game'. It is followed by the second one, elaborating stage, where students guess and explore alternative answers. The third stage is developing mathematical thinking by structuring and symbolizing. Finally, the method is ended by reinforcing stage which aims at strengthening and reflecting student's understanding. In this paper, every stage is described on the basis of practical experiences in a real mathematics classroom setting.

  6. Utilização de hidrocortisona em eqüinos submetidos a isquemia e reperfusão no jejuno e suas conseqüências sobre o cório laminar Hydrocortisone in horses submitted to jejunal isquemia and reperfusion and its effects in the laminar corium

    Directory of Open Access Journals (Sweden)

    J.J.M. Rio Tinto

    2004-06-01

    Full Text Available Estudou-se o efeito da administração de succinato sódico de hidrocortisona (SSH no desenvolvimento de lesões no cório laminar de eqüinos. Doze animais foram submetidos à laparotomia sob anestesia geral e à isquemia total em dois segmentos do jejuno, enquanto três foram usados como controle. Após uma hora de isquemia, seis animais receberam 4,0mg/kg de SSH por via intravenosa (grupo T e seis receberam placebo (grupo NT. Após duas horas de isquemia foi restabelecido o fluxo de sangue local e, decorridas duas horas de reperfusão, foi realizada a laparorrafia e permitiu-se a recuperação anestésica. Após 12 horas do início da reperfusão, os animais foram sacrificados e deles colhidas amostras de tecido laminar para avaliação histomorfológica. As alterações avaliadas ao microscópio óptico foram quantificadas por escores que variaram de 0 a 3. Os escores para lesão no tecido laminar foram semelhantes nos animais dos grupos T (0,41 e NT (0,54, permitindo concluir que a hidrocortisona não acentuou as lesões produzidas no tecido laminar após a isquemia e reperfusão no jejuno.To evaluate whether hydrocortisone sodium succinate (HSS aggravates lesions in the laminar tissue secondary to intestinal ischemia and reperfusion (IR, two segments of the jejunum were isolated in 12 halothane-anesthetized horses, and total ischemia was induced on them. Three other horses were used as controls. One hour after the onset of the ischemia, HSS (4.0mg/kg was administered intravenously to six animals (T group and saline to the others (NT group. After two hours of ischemia and two hours of reperfusion the abdomen was closed and the horses were allowed to recover from anesthesia. After 12 hours of reperfusion the horses were euthanatized and biopsy specimens were taken from the laminar tissue and the lesions were evaluated and scored. No significant differences between T (0.41 and NT (0.54 groups for laminar lesion scores were observed. The

  7. Efeito renoprotetor da estatina: modelo animal de isquemia-reperfusão Renoprotective effect of statin: a ischemia-reperfusion animal model

    Directory of Open Access Journals (Sweden)

    Claudia Akemi Shibuya Teshima

    2010-09-01

    Full Text Available OBJETIVO: A lesão renal aguda isquêmica, de causa multifatorial, apresenta morbidade e mortalidade alarmantes. A estatina, inibidor de HMG-CoA redutase, tem demonstrado papel renoprotetor, com componente antioxidante, antiinflamatório e vascular. A atividade de heme oxigenase-1 pode ser mediadora desses efeitos pleitrópicos da estatina sobre o rim, ou seja, independente da ação de redução de lipídio. Esse estudo visou avaliar se o efeito renoprotetor da estatina pode ter mecanismo heme de proteção em ratos. MÉTODOS: O modelo isquêmico foi obtido por meio do clampeamento dos pedículos renais bilaterais por 30 minutos, seguido de reperfusão. Foram utilizados ratos Wistar, machos, pesando entre 250-300g, distribuídos nos seguintes grupos: SHAM (controle, sem clampeamento renal; Isquemia; Iquemia+Estatina (sinvastatina 0,5 mg/kg, via oral por 3 dias; Isquemia+Hemin (indutor de HO-1, 1 mg/100g, intraperitoneal 24h antes da cirurgia; Isquemia+SnPP (inibidor de HO-1, 2μmol/kg intraperitoneal 24h antes da cirurgia; Isquemia+Estatina+Hemin e Isquemia+Estatina+SnPP. Foram avaliados a função renal (clearance de creatinina, Jaffé, osmolalidade urinária, peróxidos urinários e a imunohistoquímica para ED-1. RESULTADOS: Os resultados mostraram que a estatina melhorou a função renal, a osmolalidade urinária, reduziu a excreção de peróxidos urinários e a infiltração de macrófagos em rins de animais submetidos à isquemia renal. O indutor da heme oxigenase-1 e a sua associação com sinvastatina reproduziram o padrão de melhora determinado pela sinvastatina. CONCLUSÃO: O estudo confirmou o efeito renoprotetor da estatina, com ação antioxidante e antiinflamatória, e sugere que esse efeito tenha interface com o sistema heme de proteção renal.OBJECTIVE: Ischemic acute kidney injury (iLRA, with multifatorial cause, presents alarming morbidity and mortality. Statin, HMG-CoA inhibition reductase has shown a renoprotective effect

  8. Avaliação da proteína acídica fibrilar glial como marcador da injúria por isquemia-reperfusão hepática

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    Giuliano Ancelmo Bento

    Full Text Available OBJETIVO: Avaliar a expressão da Proteína Acídica Fibrilar Glial após a injúria por isquemia-reperfusão. MÉTODOS: vinte e quatro ratos foram distribuídos em quatro grupos: Controle, submetidos à anestesia e biópsia hepática; Simulação, injeção de heparina através da veia cava e dissecção do pedículo hepático superior, biópsia após 24 horas; Isquemia 30 minutos, mesmo procedimento do grupo Simulação, acrescido de clampeamento do pedículo hepático superior por 30 minutos; Isquemia 90 minutos, mesmo procedimento do grupo Isquemia 30 minutos, porém com período de clampeamento de 90 minutos. Após 24 horas de observação, os animais foram submetidos à laparotomia e seus fígados avaliados macroscopicamente, microscopicamente, por coloração de Hematoxilina-Eosina (HE e submetidos à análise da expressão da GFAP por Western Blotting. RESULTADOS: Não se observou diferença no aspecto macroscópico dos fígados entre os diferentes grupos experimentais, tendo todos evidenciado morfologia normal. A análise por HE não evidenciou diferenças significativas, no que diz respeito à morfologia lobular. Por outro lado, nos grupos isquemia, foram encontrados infiltrados neutrofílicos e pequenas áreas de necrose. A expressão de GFAP foi semelhante em todos os grupos, seja qualitativamente quanto quantitativamente. CONCLUSÃO: A expressão da Proteína Acídica Fibrilar Glial não se alterou em nosso modelo de isquemia-reperfusão.

  9. Silent, indirect strategic processes in small and medium sized enterprises

    DEFF Research Database (Denmark)

    Larsen, Mette Vinther; Madsen, Charlotte Øland; Rasmussen, Jørgen Gulddahl

    Based on empirical data we in this paper explore day-to-day strategising with an emphasis on phronesis. This way we shed some light on the nearly silent, quiet, indirect strategic change processes as they are practiced and reflected upon by leaders in small companies in their daily practice...

  10. Correlation between increased platelet ADP aggregability and silent brain infarcts

    International Nuclear Information System (INIS)

    Ono, Kenichiro; Arimoto, Hirohiko; Shirotani, Toshiki

    2012-01-01

    The purpose of this study was to investigate the correlation between platelet aggregability and silent brain infarcts. The study subjects were 445 people (264 men, 181 women; mean age, 53±14 years) with no neurologic signs, history of brain tumor, trauma, cerebrovascular disease, or antiplatelet medications. Adenosine diphosphate (ADP)-induced platelet aggregation was measured by the aggregation-size analytic method. Platelet aggregability was classified into 9 classes. The presence of headache/vertigo, hypertension, diabetes mellitus, hyperlipidemia, or smoking was elicited by questioning or blood sampling. A head MRI scan was performed, and if marked atherosclerosis or obvious stenosis in the intracranial vessels was detected, it was defined as a positive MR angiography (MRA) finding. Silent brain infarcts were detected in 26.3% of subjects. Hyperaggregability defined as that above class 6, 7, and 8 was present in 43.8%, 30.8%, and 15.7% of subjects, respectively. The risk factors for silent brain infarcts by multiple logistic regression analysis were aging, hypertension, positive MRA findings, and hyperaggregability. Platelet ADP hyperaggregability might be a risk factor for silent brain infarcts. (author)

  11. Compositionality for Markov reward chains with fast and silent transitions

    NARCIS (Netherlands)

    Markovski, J.; Sokolova, A.; Trcka, N.; Vink, de E.P.

    2009-01-01

    A parallel composition is defined for Markov reward chains with stochastic discontinuity, and with fast and silent transitions. In this setting, compositionality with respect to the relevant aggregation preorders is established. For Markov reward chains with fast transitions the preorders are

  12. Stopping the Silent Killer: Hepatitis B Among Asian Americans

    Centers for Disease Control (CDC) Podcasts

    This podcast discusses an underappreciated health threat to many Asians and Pacific Islanders in the United States: chronic infection with the hepatitis B virus. Dr. John Ward, director of CDC's Division of Viral Hepatitis, and Dr. Sam So, founder of the Asian Liver Center at Stanford University, address the importance of testing, vaccination, and care to prevent serious health consequences from this "silent" disease.

  13. Hydrocoele: A Silent Disability Affecting Quality of Life in Katakwi ...

    African Journals Online (AJOL)

    Background: Katakwi district is one of the rural districts in eastern Uganda in Teso Sub Region. The district is heavily infested with filarial worms a major cause for hydrocoele and elephantiasis if the infection is left untreated. Hydrocoele in Katakwi district are still a big cause of silent morbidity though it's an operable ...

  14. Health Education Films of the Silent Era: A Historical Analysis

    Science.gov (United States)

    Sofalvi, Alan

    2011-01-01

    Films have been used to present health messages throughout the history of the medium. The purpose of this article is to describe pictures from the silent film era that were designed to educate people about health issues. Films still available in at least one format were reviewed. Published reviews were also used to obtain information about these…

  15. silent no more: sexual violence in conflict as a challenge

    African Journals Online (AJOL)

    Rights (FIDH), Violence Against Women in Syria: Breaking the Silence, Briefing. Paper Based on an .... not perceived as the church's concern”, Silent No More, p. 8. .... travel all night to retrieve the bodies and bury them with dignity.23 In the.

  16. Perspectives on the "Silent Period" for Emergent Bilinguals in England

    Science.gov (United States)

    Bligh, Caroline; Drury, Rose

    2015-01-01

    This article draws together the research findings from two ethnographic studies as a means to problematize the "silent period" as experienced by young bilingual learners in two English speaking early-years settings in England. Most teachers and senior early-years practitioners in England are monolingual English speakers. The children…

  17. Human Schedule Performance, Protocol Analysis, and the "Silent Dog" Methodology

    Science.gov (United States)

    Cabello, Francisco; Luciano, Carmen; Gomez, Inmaculada; Barnes-Holmes, Dermot

    2004-01-01

    The purpose of the current experiment was to investigate the role of private verbal behavior on the operant performances of human adults, using a protocol analysis procedure with additional methodological controls (the "silent dog" method). Twelve subjects were exposed to fixed ratio 8 and differential reinforcement of low rate 3-s schedules. For…

  18. Using Early Silent Film to Teach French: The Language of "Cinema Muet."

    Science.gov (United States)

    Bloom, Michelle E.

    1995-01-01

    Discusses the use of early silent films in second-language classrooms, focusing on the experiences of one instructor in using early French silents in elementary and intermediate French courses. Sample lesson plans and information on the availability of French silents are also provided. (Contains 17 references.) (MDM)

  19. Oral Reading Fluency as a Predictor of Silent Reading Fluency at Secondary and Postsecondary Levels

    Science.gov (United States)

    Seok, Soonhwa; DaCosta, Boaventura

    2014-01-01

    This research investigated oral reading fluency as a predictor of silent reading fluency at the secondary and postsecondary levels. Several measures were used, including the Gray Oral Reading Test, the Test of Silent Word Reading Fluency, the Test of Silent Contextual Reading Fluency, and the Reading Observation Scale. A total of 223 students…

  20. Pseudoaneurisma Ventricular Izquierdo en Cara Inferior con Flujo Bidireccional

    Directory of Open Access Journals (Sweden)

    Adrián J Da Silva-De Abreu

    2011-01-01

    Full Text Available Los pseudoaneurismas son complicaciones infrecuentes de los infartos del miocardio. Consisten en un saco pericárdico que comunica con la cavidad ventricular a través de un cuello de menor diámetro. Se presenta el caso de una paciente de 68 años de edad, con DM II e HTA, sufre Infarto Agudo del Miocardio en Mayo del 2008, presentando disnea y tos por una semana, con diaforesis profusa de inicio súbito y síncope sin dolor precordial. El electrocardiograma reporta zonas de isquemia transmural y subendocárdica en caras inferolateral y lateral alta; respectivamente, y zona eléctricamente inactivable en cara inferior. El ecocardiograma transtorácico muestra el ventrículo izquierdo con dilatación severa, disminución de la fracción de eyección (25% y un pseudoaneurisma de la pared inferior con cuello de 3 mm a través del cual se evidencia flujo bidireccional: de entrada al ventrículo durante la diástole y salida al pseudoaneurisma en sístole. El flujo bidireccional y el gasto cardíaco disminuido contribuyen a evitar el taponamiento cardiaco, sin embargo, en condiciones de mayor demanda el pseudoaneurisma podría perforarse y ocasionar dicha entidad. De ello, la importancia del diagnostico diferencial con los aneurismas verdaderos, lo cual permite llevar a cabo la terapéutica adecuada y evitar tal complicación. Palabras claves: Pseudoaneurisma, Infarto del Miocardio, Diabetes.

    1. Pseudoaneurisma Ventricular Izquierdo en Cara Inferior con Flujo Bidireccional

      Directory of Open Access Journals (Sweden)

      Adrián J Da Silva-De Abreu

      2009-01-01

      Full Text Available Los pseudoaneurismas son complicaciones infrecuentes de los infartos del miocardio. Consisten en un saco pericárdico que comunica con la cavidad ventricular a través de un cuello de menor diámetro. Se presenta el caso de una paciente de 68 años de edad, con DM II e HTA, sufre Infarto Agudo del Miocardio en Mayo del 2008, presentando disnea y tos por una semana, con diaforesis profusa de inicio súbito y síncope sin dolor precordial. El electrocardiograma reporta zonas de isquemia transmural y subendocárdica en caras inferolateral y lateral alta, respectivamente, y zona eléctricamente inactivable en cara inferior. El ecocardiograma transtorácico muestra el ventrículo izquierdo con dilatación severa, disminución de la fracción de eyección (25% y un pseudoaneurisma de la pared inferior con cuello de 3 mm a través del cual se evidencia flujo bidireccional, de entrada al ventrículo durante la diástole y salida al pseudoaneurisma en sístole. El flujo bidireccional y el gasto cardíaco disminuido contribuyen a evitar el taponamiento cardiaco, sin embargo, en condiciones de mayor demanda el pseudoaneurisma podría perforarse y ocasionar dicha entidad. De ello, la importancia del diagnostico diferencial con los aneurismas verdaderos, lo cual permite llevar a cabo la terapéutica adecuada y evitar tal complicación.

    2. Efeitos da angiotensina-I e isquemia na recuperação funcional em corações isolados Effects of angiotensin-I and ischemia on functional recovery in isolated hearts

      Directory of Open Access Journals (Sweden)

      Ubirajara Oliveira de Oliveira

      2011-11-01

      Full Text Available FUNDAMENTO: A ressuscitação de parada cardíaca pode apresentar disfunção miocárdica determinada pelo tempo da isquemia, e a inibição da enzima conversora de angiotensina (ECA pode reduzir a disfunção cardíaca durante a reperfusão. OBJETIVO: Investigar os efeitos da angiotensina-I e diferentes períodos de isquemia na recuperação funcional em corações de ratos isolados. MÉTODOS: Os corações isolados de ratos Wistar (n = 45; 250-300 g foram submetidos a diferentes períodos de isquemia global (20, 25 ou 30 min e reperfundidos (30 min com o tampão Krebs-Henseleit, ou com a adição de 400 nmol/L de angiotensina-I, ou com 400 nmol/L de angiotensina-I + 100 µmol/L de captopril durante o período de reperfusão. RESULTADOS: A derivada positiva máxima de pressão (+dP/dt max e o produto frequência-pressão foram reduzidos nos corações expostos à isquemia de 25 min (~ 73% e à isquemia de 30 min (~ 80% vs. isquemia de 20 min. A pressão diastólica final do ventrículo esquerdo (PDFVE e a pressão de perfusão (PP foram aumentadas nos corações expostos à isquemia de 25 min (5,5 e 1,08 vezes, respectivamente e à isquemia de 30 min (6 e 1,10 vezes, respectivamente vs. isquemia de 20 min. A angiotensina-I ocasionou uma diminuição no +dP/dt max e no produto frequência-pressão (~ 85-94% em todos os períodos de isquemia e um aumento na PDFVE e na PP (6,9 e 1,25 vezes, respectivamente apenas na isquemia de 20 min. O captopril foi capaz de reverter parcial ou completamente os efeitos da angiotensina-I na recuperação funcional nas isquemias de 20 e 25 min CONCLUSÃO: Os dados sugerem que a angiotensina-II participa direta ou indiretamente no dano pós-isquêmico e que a capacidade de um inibidor da ECA atenuar esse dano depende do tempo de isquemia.BACKGROUND: Cardiac arrest resuscitation can present myocardial dysfunction determined by ischemic time, and inhibition of the angiotensin-converting enzyme (ACE can reduce cardiac

    3. Análise eletromiográfica e força do grupo muscular extensor do punho durante isquemia induzida Electromyographic analysis and strength of the wrist extensor muscle group during induced ischemia

      Directory of Open Access Journals (Sweden)

      CCA Bandeira

      2009-02-01

      Full Text Available OBJETIVO: Avaliar o efeito da isquemia induzida sobre os parâmetros do sinal eletromiográfico e a força do grupo muscular extensor do punho (GMEP em mulheres saudáveis. MÉTODOS: Participaram 13 voluntárias, destras, sedentárias, com idade de 23,38±2,32 anos e índice de massa corporal (IMC de 20,68±1,87kg/m². Para determinar a força do GMEP, foram realizadas 3 contrações isométricas voluntárias máximas (CIVM, utilizando-se uma célula de carga por 15 segundos, com intervalos de 2 minutos entre cada contração, sendo todo procedimento repetido por 3 dias não consecutivos. A isquemia foi realizada por 5 minutos, utilizando um esfigmomanômetro posicionado no braço dominante e inflado até a ausência do fluxo sanguíneo, confirmada pelo ultrassom Doppler. Para coleta do sinal eletromiográfico do GMEP, utilizou-se o equipamento EMG1000 (Lynx® com eletrodo de superfície diferencial (Lynx®. Foram coletadas 3 CIVM por 15 segundos, com intervalo de 30 segundos entre elas, nas situações de pré-isquemia; isquemia; pós-isquemia imediata (pós-1 e pós-isquemia tardia (pós-2 - após 10 minutos do início da isquemia. Para análise dos parâmetros do sinal eletromiográfico, root mean square (RMS, e frequência mediana do espectro de potência do sinal foi utilizado o software MATLAB 6.5.1. Para análise estatística, foram utilizados os testes de Friedman e ANOVA two-way. RESULTADOS: A isquemia promoveu redução significativa (pOBJECTIVE: To analyze the effect of induced ischemia on the parameters of electromyographic signals and the strength of the wrist extensor muscle group (WEMG in healthy women. METHODS: Thirteen right-handed sedentary subjects aged 23.38±2.32 years old, with body mass index (BMI of 20.68±1.87kg/m², took part. To determine WEMG strength, three maximal voluntary isometric contractions (MVIC were performed using a load cell for 15 seconds, with 2 minutes intervals between contractions. The entire

    4. Efeito do meloxicam sobre a lesão de isquemia e reperfusão em músculo esquelético de ratos Effect of meloxicam on ischemia-reperfusion injury in skeletal muscle of rats

      Directory of Open Access Journals (Sweden)

      Vitor A. Uhle

      2000-01-01

      Full Text Available Os antiinflamatórios não esteroidais, derivados do piroxicam, agem como varredores de radicais livres de oxigênio em experimentos in vitro. O objetivo deste trabalho foi analisar o efeito do meloxicam em músculos esqueléticos de ratos submetidos à isquemia e reperfusão com base na análise de liberação de malondialdeído da membrana celular ( indicador de peroxidação lipídica provocada pelos radicais livres. Dezoito ratos Wistar foram divididos em 2 grupos de 9. O grupo I (grupo sham foi tratado previamente com 3g/kg de peso de solução fisiológica e o grupo II com 3g/kg de peso de meloxicam por via peritoneal. Após 5 min os ratos foram submetidos a 3h de isquemia total ( torniquete e 45 min de reperfusão das patas posteriores esquerdas. Colheram-se biópsias dos músculos isquêmicos e reperfundidos e das patas controles (contralaterais para a dosagem de malondialdeído. A análise das diferenças de concentração do malondiadeído nas patas controles e reperfundidas no grupo I (43,7± 60,7; n=9 em relação ao grupo II (21,7± 49,5; n=9 não mostrou alteração significante (p=0,3. Os dados obtidos, neste trabalho, mostram que o meloxicam não protege a musculatura esquelética dos danos causados pela isquemia e reperfusão, com base na análise do malondialdeído tissular após 3h de isquemia e 45 min de reperfusão.

    5. Efeito da deferoxamina na isquemia e reperfusão do fígado remanescente após ressecção hepática parcial

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      Brisotti João Luiz

      2000-01-01

      Full Text Available Particularmente, a utilização de vários tipos de drogas que diminuem os efeitos deletérios do binômio isquemia-reperfusão, tem tornado-se foco de vários estudos experimentais visando possíveis aplicações clínicas. O objetivo do presente estudo foi avaliar os efeitos da deferoxamina na isquemia e reperfusão sobre o fígado remanescente após ressecção hepática parcial a 70%, avaliando-se váriáveis bioquímicas do sangue: aspartato aminotransferase e alanina aminotransferase;.A amostra de 34 ratos foi dividida em grupos: Grupo HP (n = 8 - submetidos a hepatectomia parcial (HP a 70%; Grupo HPD (n = 4 - submetidos a administração de deferoxamina (40 mg/kg e HP a 70%; Grupo HPI (n = 7 - hepatectomizados (HP a 70% e submetidos a isquemia (40 minutos; Grupo HPID (n = 7 - semelhante ao anterior, porém recebendo previamente deferoxamina; Grupo C (n = 8 - controle, submetido a operação simulada para HP a 70%. A análise estatística entre os diversos grupos foi feita pelos testes de Kruskal - Wallis e de Mann - Whitney, com nível de significância de 5%. Portanto, houve aumento significativo das aminotransferases nos animais submetidos a hepatectomia e a isquemia. Esse aumento foi inibido pela deferoxamina.

    6. Anamnesis and the Silent Narrator in Plato and John

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      George L. Parsenios

      2017-03-01

      Full Text Available The Gospel of John is often compared to the dialogues of Plato by those who connect Johannine theology and Platonic philosophy. The comparison operates on the level of ideas. The present paper does not ignore issues of theology and philosophy but grounds a comparison of John and Plato first and foremost on the literary level. In several key places in John 1, 3, and 14, the Johannine narrator recedes from view and is unexpectedly silent where one would expect a narrator’s comment to organize the conversations and interactions between characters in John. Plato also renders the voice of the narrator silent in a dialogue like the Theaetetus. This paper argues that John and Plato both suppress the narrator’s voice in order to further their anamnetic efforts and to make later generations not only readers but participants in their original conversations.

    7. Silent Warning: Understanding the National Terrorism Advisory System

      Science.gov (United States)

      2014-12-01

      NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited SILENT WARNING...PERFORMING OR GANIZATION NA:i\\ti E (S) AND ADDRESS(ES) Naval Postgraduate School Monterey, CA 93943-5000 9. SP ONSORING /MONIT ORING AGENCY NAME(S) AND...Homeland Sectu’ity Advisory System, Boston Marathon bombing, Christmas Day bomber, tmderwear bomber, hum cane , cotmteiteiTO!’ism, CT AB

    8. Incidence and implications of silent hydronephrosis following percutaneous nephrolithotomy
.

      Science.gov (United States)

      Dagrosa, Lawrence; Moses, Rachel; Pais, Vernon M

      2017-01-01

      While routine renal imaging following ureteroscopy for urinary calculi has been recommended to screen for asymptomatic "silent" obstruction, the rate of silent obstruction following percutaneous nephrolithotomy (PCNL) remains poorly defined, and no consensus recommendations exist on routine postoperative imaging. At our institution, we sought to assess the incidence of silent hydronephrosis (SH), as a screen for obstruction, following PCNL. The records of all 162 patients who met study inclusion criteria were reviewed. Of this group, 112 patients presented for their scheduled renal ultrasonography 4 - 6 weeks following stent removal to screen for SH. Asymptomatic patients found to have ultrasonographic evidence of hydronephrosis were further analyzed. SH was noted in 16% (18/112) of patients. Two required subsequent ureteroscopic stone extraction (1.8%), one of which also underwent endoureterotomy for a ureteral stricture. Four patients (22%) had stable hydronephrosis and declined functional imaging, 2 patients (11%) had a known partial ureteropelvic junction obstruction and declined intervention. SH resolved spontaneously in 50% (9/18) with a mean time to resolution of 6.3 months. There was no difference in stone complexity based on Guy's stone score between groups, 2.8 (± 0.92) vs. 2.4 (± 1.03), p = 0.34. Although not statistically significant, patients with SH were more likely to have had residual stone fragments postoperatively, 39% (7/18) vs. 19% (18/94), p = 0.067. SH following, PCNL was identified in 16% of this screened population, with the majority requiring no intervention. However, SH may be attributed to residual stone or stricture, which may have been otherwise unrecognized in up to 2% of patients undergoing PCNL. Consideration should be given for routine postoperative ultrasound to screen for silent obstruction following PCNL.
.

    9. Transluminal coronary angioplasty in the treatment of silent ischemia

      International Nuclear Information System (INIS)

      Bergin, P.; Myler, R.K.; Shaw, R.E.; Stertzer, S.H.; Clark, D.A.; Ryan, C.; Murphy, M.C.

      1988-01-01

      Fifty-four asymptomatic patients with positive thallium exercise tests underwent coronary angiography followed by coronary angioplasty (PTCA), as the primary therapy for silent ischemia. The procedure was technically successful in 89% of these patients. Emergency bypass graft surgery was necessary in 2 (3.6%) and q-wave myocardial infarction occurred in 1 (1.8%) of these. All fifty-four patients have been followed for a mean of 35 months since angioplasty. Of the 48 patients with initially successful PTCA, 12 had either clinical restenosis (9/14 or 19%) or a new lesion (3/48 or 6%) during follow-up, which required a repeat PTCA. At the longest follow-up, 46 (85%) had been successfully treated with on or more PTCA procedures. Two patients (3.6%) had sustained late q-wave myocardial infarction and two additional patients reported angina pectoris. There were no deaths. Angioplasty as a primary therapy for silent ischemia appears efficacious, with success and restenosis rates comparable to those in the symptomatic population. Event-free survival is improved, compared with natural history data for patients with silent ischemia from other studies. Prudent risk/benefit analysis may help to define subgroups most likely to benefit from this intervention

    10. Prevalence of silent gastrointestinal complications in maintenance renal transplant population

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      Teplitsky Susan

      2010-01-01

      Full Text Available This study aims to determine the prevalence of silent GI complications within a stable renal transplant population and to investigate whether the conversion to enteric-coated myco-phenolate sodium (EC-MPS, Myfortic; would improve symptom scores. This was a single-center, open-label, non-randomized, prospective study. Patients without any history of GI com-plaints were evaluated by means of the gastrointestinal symptom rating scale (GSRS, with subse-quent switch to EC-MPS in a group of patients. Silent complications were defined as patients who voiced no GI complaints at clinic visits despite a score of ≥ 2 on GSRS scale. A total of 236 stable patients participated in the trial. The prevalence of baseline scores ≥ 2 was relatively high with abdominal pain 29.66%, reflux 37.28%, indigestion 50%, constipation 58.47% and diarrhea 33.4%. Of 236 patients, 80 were converted to EC-MPS. There was statistically significant improvement on all scales in the subgroup of patients with GSRS score ≥ 2 (P< 0.05. In conclusion, the GSRS scale identified a high percentage of silent gastrointestinal complications in this renal transplant population. The converted patients with higher GSRS scores reported a sustained improvement.

    11. Assessing reading fluency in Kenya: Oral or silent assessment?

      Science.gov (United States)

      Piper, Benjamin; Zuilkowski, Stephanie Simmons

      2015-04-01

      In recent years, the Education for All movement has focused more intensely on the quality of education, rather than simply provision. Many recent and current education quality interventions focus on literacy, which is the core skill required for further academic success. Despite this focus on the quality of literacy instruction in developing countries, little rigorous research has been conducted on critical issues of assessment. This analysis, which uses data from the Primary Math and Reading Initiative (PRIMR) in Kenya, aims to begin filling this gap by addressing a key assessment issue - should literacy assessments in Kenya be administered orally or silently? The authors compared second-grade students' scores on oral and silent reading tasks of the Early Grade Reading Assessment (EGRA) in Kiswahili and English, and found no statistically significant differences in either language. They did, however, find oral reading rates to be more strongly related to reading comprehension scores. Oral assessment has another benefit for programme evaluators - it allows for the collection of data on student errors, and therefore the calculation of words read correctly per minute, as opposed to simply words read per minute. The authors therefore recommend that, in Kenya and in similar contexts, student reading fluency be assessed via oral rather than silent assessment.

    12. Manejo da hipertensão arterial na isquemia cerebral aguda Management of arterial hypertension in patients with acute ischemic stroke

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      WALTER JOSÉ FAGUNDES-PEREYRA

      1999-12-01

      Full Text Available OBJETIVO: Avaliar o nível de conhecimento dos médicos, através de sua conduta, em paciente com quadro de hipertensão arterial na fase aguda da isquemia cerebral. Também comentamos as principais condutas nesta fase, com ênfase na tensão arterial (TA. MÉTODO: Foram entrevistados 120 médicos da clínica médica e da cirurgia geral, em dez dos maiores Hospitais de Belo Horizonte, em 1997. Todos responderam a um questionário contendo um caso clínico de paciente hipertenso leve, admitido com quadro de isquemia cerebral e tensão arterial de 186x110 mmHg. Os profissionais deveriam optar por reduzir, aumentar ou manter a TA. RESULTADOS: Dos entrevistados, 38 (31,7% responderam que reduziriam os níveis tensionais, 82 (68,3% optaram pela manutenção e nenhum aumentaria (pPURPOSE: We aimed with study to assess the current clinical practice about the management of high blood pressure in patients in the acute phase of ischemic stroke. We also comment some topics of ischemic stroke treatment. METHODS: A case report of a patient admitted 8 hours after onset of ischemic stroke and with blood pressure of 186x110 mmHg was presented to 120 surgeons and clinician. They were asked to decide the best therapeutic option: to increase, decrease or maintenance blood pressure. RESULTS: Thirty-eight physicians (31,7% considered decreasing blood pressure the best therapeutics, 82 (68,3% considered maintenance and none decided to increase it (p < 0.05. There was no difference between the two specialties conduct. The physicians, with more than 10 years of graduation, had a tendency to decrease the blood pressure (p <0.05. CONCLUSION: The maintenance of blood pressure may present a sufficient blood support to compensate brain flow. A high percentage of the physicians (31,7% do not know about the current concepts of therapeutics considering hypertension in acute ischemic stroke. The development on special units to treat these patients ("stroke units" may eventually

    13. Pathophysiology of mesenteric ischemia/reperfusion: a review Fisiopatologia da isquemia e reperfusão mesentérica: revisão

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      Nereide Freire Cerqueira

      2005-08-01

      Full Text Available During ischemia, the cell structures are progressively damaged, but restoration of the blood flow, paradoxically, intensifies the lesions caused by the ischemia. The mechanisms of ischemia injury and reperfusion (I/R have not been completely defined and many studies have been realized in an attempt to find an ideal therapy for mesenteric I/R. The occlusion and reperfusion of the splanchnic arteries provokes local and systemic alterations principally derived from the release of cytotoxic substances and the interaction between neutrophils and endothelial cells. Substances involved in the process are discussed in the present review, like oxygen-derived free radicals, nitric oxide, transcription factors, complement system, serotonin and pancreatic proteases. The mechanisms of apoptosis, alterations in other organs, therapeutic and evaluation methods are also discussed.Durante a isquemia, as estruturas celulares são progressivamente lesadas, mas a restauração do fluxo sanguíneo, paradoxalmente, pode agravar o dano celular isquêmico. O mecanismo das lesões de isquemia e reperfusão (I/R ainda não foram completamente definidos e muitos estudos têm sido realizados na tentativa de encontrar uma terapia ideal para I/R mesentérica. A oclusão e a reperfusão das artérias esplâncnicas provocam alteracões locais e sistêmicas derivadas principalmente da liberação de substâncias citotóxicas e da interação entre neutrófilos e células endoteliais. As substâncias envolvidas no processo, como radicais livres derivados do oxigênio, óxido nítrico, fatores de transcrição, sistema complemento, serotonina e proteases pancreáticas, são discutidas na presente revisão. Os mecanismos de apoptose, repercussão sistêmica, terapêutica e métodos de avaliação também são discutidos.

    14. Dolor Cráneo-facial como Síntoma Aislado de Isquemia Cardíaca: Estudio prospectivo y multicéntrico

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      Marcelo Kreiner

      Full Text Available RESUMEN Antecedentes. El dolor craneofacial puede ser el único síntoma de una isquemia cardíaca. El fracaso en reconocer el origen cardíaco de dicho dolor puede poner en riesgo la vida del paciente. Los autores realizaron un estudio para revelar la prevalencia, la distribución y las diferencias entre sexos en lo que respecta al dolor craneofacial de origen cardíaco. Métodos. Los autores seleccionaron de forma prospectiva pacientes consecutivos (n= 186 que habían presentado un episodio isquémico cardíaco verificado. Estudiaron en detalle la localización y distribución del dolor craneofacial e intraoral. Resultados. El dolor cráneofacial fue el único síntoma durante el episodio isquémico en 11 pacientes (6%, tres de los cuales presentaron un infarto agudo de miocardio (IAM. Otros 60 pacientes (32% comunicaron dolor cráneofacial concomitantemente a dolor en otras regiones. Las localizaciones más frecuentes del dolor cráneofacial fueron la garganta, la región mandibular izquierda, la región mandibular derecha, la articulación temporomandibular izquierda / oído y dientes. El dolor cráneofacial se manifestó de forma predominante en mujeres (P= 0,031 y fue el síntoma dominante en ambos sexos en ausencia de dolor torácico. Conclusiones. El dolor cráneofacial es inducido frecuentemente por isquemia cardíaca. Esta causa debe tenerse en cuenta en el diagnóstico diferencial del dolor dental y orofacial. Implicaciones clínicas. Debido a que los pacientes que tienen un IAM sin dolor torácico corren un mayor riesgo de no ser correctamente diagnosticados y de muerte, el alerta del clínico sobre esta sintomatología puede ser crucial para el diagnóstico precoz y un rápido tratamiento

    15. Differences in autonomic nerve function in patients with silent and symptomatic myocardial ischaemia.

      Science.gov (United States)

      Shakespeare, C. F.; Katritsis, D.; Crowther, A.; Cooper, I. C.; Coltart, J. D.; Webb-Peploe, M. W.

      1994-01-01

      BACKGROUND--Autonomic neuropathy provides a mechanism for the absence of symptoms in silent myocardial ischaemia, but characterisation of the type of neuropathy is lacking. AIM--To characterise and compare autonomic nerve function in patients with silent and symptomatic myocardial ischaemia. METHODS AND RESULTS--The Valsalva manoeuvre, heart rate variation (HRV) in response to deep breathing and standing, lower body negative pressure, isometric handgrip, and the cold pressor test were performed by patients with silent (n = 25) and symptomatic (n = 25) ambulatory ischaemia and by controls (n = 21). No difference in parasympathetic efferent function between patients with silent and symptomatic ischaemia was recorded, but both had significantly less HRV in response to standing than the controls (p < 0.005 for silent and p < 0.01 for symptomatic). Patients with silent ischaemia showed an increased propensity for peripheral vasodilatation compared with symptomatic patients (p < 0.02) and controls (p < 0.04). Impaired sympathetic function was found in patients with pure silent ischaemia (n = 4) compared with the remaining patients with silent ischaemia whose pain pathways were presumed to be intact. CONCLUSIONS--Patients with silent ischaemia and pain pathways presumed to be intact have an enhanced peripheral vasodilator response, and if this applied to the coronary vasculature it could provide a mechanism for limiting ischaemia to below the pain threshold. Patients with pure silent ischaemia have evidence of sympathetic autonomic dysfunction. Images PMID:8297687

    16. Silence, Metaperformance, and Communication in Pedro Almodóvar's "Hable con ella"

      Science.gov (United States)

      Fellie, Maria C.

      2016-01-01

      Many scenes in Pedro Almodóvar's "Hable con ella" (2002) include shots of metaperformances such as silent films, dances, television shows, concerts, and bullfights. Spectators often observe passive characters who are in turn observing. By presenting these performances within cinematic performance, Almodóvar highlights our role as viewers…

    17. Anastomose arterial extra-intracraniana para tratamento de paciente com isquemia cerebral refratária ao manejo clínico

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      Falavigna Asdrubal

      2004-01-01

      Full Text Available A anastomose extra-intracraniana pode ser utilizada em casos selecionados de insuficiência vascular encefálica refratária ao tratamento clínico. Descrevemos um caso de isquemia encefálica em território de artéria cerebral média direita devida à oclusão da artéria carótida interna homolateral com conseqüente redução da perfusão e reserva vascular nos hemisférios frontal e parietal. Apesar do tratamento clínico, a melhora do déficit motor estava relacionada diretamente com a manutenção de níveis tensionais sistêmicos elevados pelo uso de vasopressor. Após anastomose extra-intracraniana término-lateral entre as artérias temporal superficial e cerebral média direita, houve melhora significativa da perfusão cerebral com remissão do déficit motor.

    18. Silent pituitary macroadenoma co-secreting growth hormone and thyroid stimulating hormone.

      Science.gov (United States)

      Sen, Orhan; Ertorer, M Eda; Aydin, M Volkan; Erdogan, Bulent; Altinors, Nur; Zorludemir, Suzan; Guvener, Nilgun

      2005-04-01

      Silent pituitary adenomas are a group of tumors showing heterogenous morphological features with no hormonal function observed clinically. To date no explanation has been provided as to why these tumors remain "silent". We report a case of a silent macroadenoma with both growth hormone (GH) and thyroid stimulating hormone (TSH) staining and secretion but with no clinical manifestations, in particular, the absence of features of acromegaly or hyperthyroidism. The relevant literature is reviewed.

    19. The Rachel Carson Letters and the Making of Silent Spring

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      John Paull

      2013-06-01

      Full Text Available Environment, conservation, green, and kindred movements look back to Rachel Carson’s 1962 book Silent Spring as a milestone. The impact of the book, including on government, industry, and civil society, was immediate and substantial, and has been extensively described; however, the provenance of the book has been less thoroughly examined. Using Carson’s personal correspondence, this paper reveals that the primary source for Carson’s book was the extensive evidence and contacts compiled by two biodynamic farmers, Marjorie Spock and Mary T. Richards, of Long Island, New York. Their evidence was compiled for a suite of legal actions (1957-1960 against the U.S. Government and that contested the aerial spraying of dichlorodiphenyltrichloroethane (DDT. During Rudolf Steiner’s lifetime, Spock and Richards both studied at Steiner’s Goetheanum, the headquarters of Anthroposophy, located in Dornach, Switzerland. Spock and Richards were prominent U.S. anthroposophists, and established a biodynamic farm under the tutelage of the leading biodynamics exponent of the time, Dr. Ehrenfried Pfeiffer. When their property was under threat from a government program of DDT spraying, they brought their case, eventually lost it, in the process spent US$100,000, and compiled the evidence that they then shared with Carson, who used it, and their extensive contacts and the trial transcripts, as the primary input for Silent Spring. Carson attributed to Spock, Richards, and Pfeiffer, no credit whatsoever in her book. As a consequence, the organics movement has not received the recognition, that is its due, as the primary impulse for Silent Spring, and it is, itself, unaware of this provenance.

    20. Assessment of Silent T1-weighted head imaging at 7 T

      Energy Technology Data Exchange (ETDEWEB)

      Costagli, Mauro; Tiberi, Gianluigi; Tosetti, Michela [Imago7 Foundation, Pisa (Italy); IRCCS Stella Maris, Laboratory of Medical Physics and Biotechnologies for Magnetic Resonance, Pisa (Italy); Symms, Mark R. [GE Applied Science Laboratory, Pisa (Italy); Angeli, Lorenzo [University of Pisa, Department of Translational Research and New Technologies in Medicine and Surgery, Pisa (Italy); Kelley, Douglas A.C. [GE Healthcare Technologies, San Francisco, CA (United States); Biagi, Laura [IRCCS Stella Maris, Laboratory of Medical Physics and Biotechnologies for Magnetic Resonance, Pisa (Italy); Farnetani, Andrea [University of Ferrara, Engineering Department, Ferrara (Italy); Materiacustica s.r.l., Ferrara (Italy); Rua, Catarina [University of Pisa, Department of Physics, Pisa (Italy); Donatelli, Graziella [Azienda Ospedaliero-Universitaria Pisana (AOUP), Neuroradiology Unit, Department of Diagnostic and Interventional Radiology, Pisa (Italy); Cosottini, Mirco [Imago7 Foundation, Pisa (Italy); University of Pisa, Department of Translational Research and New Technologies in Medicine and Surgery, Pisa (Italy)

      2016-06-15

      This study aimed to assess the performance of a ''Silent'' zero time of echo (ZTE) sequence for T1-weighted brain imaging using a 7 T MRI system. The Silent sequence was evaluated qualitatively by two neuroradiologists, as well as quantitatively in terms of tissue contrast, homogeneity, signal-to-noise ratio (SNR) and acoustic noise. It was compared to conventional T1-weighted imaging (FSPGR). Adequacy for automated segmentation was evaluated in comparison with FSPGR acquired at 7 T and 1.5 T. Specific absorption rate (SAR) was also measured. Tissue contrast and homogeneity in Silent were remarkable in deep brain structures and in the occipital and temporal lobes. Mean tissue contrast was significantly (p < 0.002) higher in Silent (0.25) than in FSPGR (0.11), which favoured automated tissue segmentation. On the other hand, Silent images had lower SNR with respect to conventional imaging: average SNR of FSPGR was 2.66 times that of Silent. Silent images were affected by artefacts related to projection reconstruction, which nevertheless did not compromise the depiction of brain tissues. Silent acquisition was 35 dB(A) quieter than FSPGR and less than 2.5 dB(A) louder than ambient noise. Six-minute average SAR was <2 W/kg. The ZTE Silent sequence provides high-contrast T1-weighted imaging with low acoustic noise at 7 T. (orig.)

    1. Estudo da fração inspirada de oxigênio na isquemia-reperfusão pulmonar em ratos Study of ventilation with different inspired oxygen concentration on lung ischaemia-reperfusion injury in rats

      Directory of Open Access Journals (Sweden)

      Rafael José Silveira

      2004-10-01

      Full Text Available OBJETIVO: Estudar o efeito das frações inspiradas de oxigênio (FiO2 a 0,21, 0,40 e 1,00 na isquemia-reperfusão pulmonar. MÉTODOS: Foram utilizados 40 ratos Wistar, distribuídos aleatoriamente em quatro grupos. O grupo I foi o controle e, nos grupos II, III e IV, os animais foram ventilados durante a isquemia-reperfusão com FiO2 a 0,21, 0,40 e 1,00 respectivamente. O modelo utilizado foi de isquemia-reperfusão normotérmica, in situ. O tempo de isquemia foi de 30 minutos e o de reperfusão, de 10 minutos. Como parâmetros de avaliação, utilizou-se a pressão arterial média sistêmica (PAM, a relação entre a pressão parcial de oxigênio e a fração inspirada de oxigênio (PO2/FiO2, a dosagem da glutationa reduzida (GSH e das substâncias reativas ao ácido tiobarbitúrico (TBARS no tecido pulmonar e a relação entre o peso pulmonar úmido e o peso pulmonar seco. RESULTADOS: Os resultados mostraram que a ventilação com FiO2 a 0,21, quando comparada à ventilação com FiO2 a 0,40 e 1,00, durante o período de isquemia-reperfusão, apresentou menor diminuição da PAM, melhor relação PO2/FiO2, maior valor na medida da GSH, menor produção das TBARS e menor formação de edema pulmonar. CONCLUSÃO: A ventilação com baixa FiO2 (0,21 mostrou melhores resultados quando comparada àquelas realizadas com FiO2 mais elevadas (0,40 e 1,00 na isquemia-reperfusão pulmonar.PURPOSE: To evaluate the FiO2 effect at 0,21, 0,40 and 1,00 on the lung ischaemia-reperfusion injury. METHODS: Forty Wistar rats were randomly allocated in 4 groups. The group I was the control one, and in groups II, III, IV rats were ventilated during the ischaemia-reperfusion at 0,21, 0,40 and 1.00 FiO2 respectively. The ischaemia time was 30 minutes and the reperfusion time was 10 minutes. The model used was normothermic ischaemia-reperfusion, in situ. As assessment parameters, the systemic average arterial pressure (PAM, the oxygen arterial partial pressure

    2. Avaliação do pós-condicionamento isquêmico no tratamento da isquemia mesentérica: estudo experimental em ratos Evaluation of ischemic postconditioning effect on mesenteric ischemia treatment: experimental study in rats

      Directory of Open Access Journals (Sweden)

      Carlos Henrique Marques dos Santos

      2009-06-01

      Full Text Available OBJETIVO: Avaliar o efeito do pré e pós-condicionamento isquêmico sobre a lesão tecidual na mucosa intestinal de ratos submetidos ao processo de isquemia e reperfusão mesentérica. MÉTODOS: Foram estudados 30 ratos Wistar, distribuídos em três grupos: grupo A, em que se realizou isquemia (30 minutos e reperfusão (60 minutos mesentérica; grupo B, isquemia e reperfusão mesentérica precedidos pelo pré-condicionamento isquêmico por três ciclos de isquemia e reperfusão com duração de dois minutos cada; grupo C, isquemia e reperfusão mesentérica e, precedendo o início da reperfusão, foi realizado o pós-condicionamento isquêmico por três ciclos de reperfusão e isquemia com duração de dois minutos cada. Ao final, ressecou-se um segmento do intestino delgado para análise histológica. Avaliaram-se os resultados pela classificação de Chiu et al. e procedeu-se ao tratamento estatístico. RESULTADOS: As médias dos graus de lesão tecidual segundo a classificação de Chiu et al. foram: no grupo A, 3,5; grupo B, 1,2; grupo C, 1. A diferença entre o resultado do grupo A com os resultados dos grupos B e C foi considerada estatisticamente significativa (P OBJECTIVE: To assess the preconditioning and postconditioning effect on intestinal mucosal lesions in rats undergone mesenteric ischemia and reperfusion procedure. METHODS: Thirty Wistar rats were studied and divided into three groups: Group A, 10 rats undergone mesenteric ischemia (30 minutes and reperfusion (60 minutes; Group B, 10 rats undergone mesenteric ischemia and reperfusion preceded by ischemic preconditioning for three cycles of ischemia and reperfusion for two minutes each; Group C, 10 rats undergone mesenteric ischemia and reperfusion and, preceding the beginning of reperfusion, ischemic postconditioning was performed for three cycles of reperfusion and ischemia for two minutes each. Then, a segment of small intestine was resected for histological analysis. We

    3. Tratamiento de la compresión del tronco de la arteria coronaria izquierda en pacientes con hipertensión pulmonar

      Directory of Open Access Journals (Sweden)

      María L. Talavera

      2011-10-01

      Full Text Available La angina de pecho es un síntoma frecuente en pacientes con hipertensión pulmonar (HP de cualquier etiología. Aunque su fisiopatología no está aclarada, las causas propuestas son: la isquemia subendocárdica por aumento del estrés parietal del ventrículo derecho, la dilatación de la arteria pulmonar por incrementos transitorios de la presión pulmonar y la compresión extrínseca del tronco de la arteria coronaria izquierda (TCI por la arteria pulmonar (AP dilatada. Se presentan tres casos que muestran la relación entre la angina de pecho y la compresión del TCI en pacientes con HP asociada a cardiopatías congénitas, tratados mediante implante de stent coronario.

    4. Electrocardiographically and symptomatically silent myocardial ischemia during exercise testing

      International Nuclear Information System (INIS)

      Kurata, Chinori; Tawarahara, Kei; Sakata, Kazuyuki; Taguchi, Takahisa; Fukumoto, Yoshihiro; Kobayashi, Akira; Yamazaki, Noboru; Tanaka, Hiroshi

      1991-01-01

      Certain patients with coronary artery disease (CAD) may have neither ST depression nor chest pain during exercise despite the presence of myocardial ischemia. The frequency and characteristics of such electrocardiographically and symptomatically silent ischemia were studied in 171 patients with both angiographically documented CAD and scintigraphically documented ischemia. Fifty-six (33%) of 171 patients had neither ST depression nor chest pain (Group N), and 115 (67%) had ST depression and/or chest pain (Group P). The two groups were similar with respect to age, gender, the prevalence of prior infarction, and peak systolic blood pressure. Group N patients, however, had a higher mean peak heart rate and rate-pressure product, less severe scintigraphic ischemia, a lower lung thallium-201 uptake, and a smaller number of diseased vessels. Stepwise discriminant analysis showed a history of effort angina, lung thallium-201 uptake, and scintigraphic severity of ischemia to be significant discriminators between Groups N and P. In conclusion, electrocardiographically and symptomatically silent ischemia may be common during exercise in patients with CAD, and less severe ischemia may be one of important determinants. (author)

    5. As bases experimentais da lesão por isquemia e reperfusão do fígado: revisão The experimental basis of hepatic ischemia-reperfusion injury: review

      Directory of Open Access Journals (Sweden)

      Luiz Eduardo C. Miranda

      2004-01-01

      Full Text Available O transplante hepático tornou-se o procedimento de escolha para o tratamento da doença hepática terminal. Não obstante o sucesso da cirurgia, a disfunção pós-operatória do fígado enxertado ainda representa importante causa de morbidade e mortalidade. O restabelecimento do fluxo sangüíneo ao fígado recém transplantado impõe a ele nova agressão, agravando a lesão causada pelo período de isquemia. Este fenômeno pouco compreendido é conhecido como lesão por isquemia e reperfusão e envolve disfunção endotelial, seqüestro de leucócitos e agregação de plaquetas, lesão por radicais livre de oxigênio, e distúrbios da microcirculação hepática. Essa revisão discute os vários aspectos fisiopatológicos que estão envolvidos na lesão por isquemia e reperfusão do fígado.Hepatic transplantation has become the main treatment for patients with terminal hepatic disease. Whatever the success of such surgery, the hepatic dysfunction associated with liver transplantation is an important cause of morbidity and mortality. Paradoxically, on restoring the blood supply, the liver is subjected to a further insult, aggravating the injury already caused by ischemia. This complex phenomenon is termed ischemia-reperfusion injury and involves endothelial cell dysfunction, leukocyte entrapment, platelet aggregation, oxidant stress and hepatic microcirculatory perfusion failure. This review discusses the physiopathlogicals mechanisms of liver ischemia-reperfusion injury.

    6. Isquemia hepática normotérmica em ratos: estudo da lesão celular através do uso de clampeamento pedicular contínuo e intermitente

      Directory of Open Access Journals (Sweden)

      Fabio Neves da Silva

      Full Text Available OBJETIVO: Avaliar as alterações bioquímicas decorrentes da isquemia hepática normotérmica, seguida de reperfusão em duas modalidades de clampeamento da tríade portal em ratos. MÉTODO: Trinta ratos Wistar machos pesando entre 250 e 320 gramas foram divididos em três grupos de 10 animais cada. Induzimos 40 minutos de isquemia hepática por clampeamento pedicular contínuo (grupo I ou intermitente (grupo II. No grupo controle não houve clampeamento. Como parâmetro de lesão hepatocelular adotamos a concentração plasmática de: transaminase glutâmico oxalacética (TGO, transaminase glutâmico pirúvica (TGP e lactato desidrogenase (LDH. Colhemos as amostras de sangue no início (T1 e no final da cirurgia (T2. Todos os animais foram submetidos ao mesmo tempo operatório: 60 minutos. RESULTADOS: Não houve diferença estatística nos valores iniciais (T1 das três enzimas nos três grupos. Todos apresentaram aumento significativo das enzimas do momento 1 (T1 para o momento 2 (T2. Houve diferença estatística no aumento médio de TGO e TGP entre os três grupos, sendo o maior aumento encontrado no grupo I e o menor, no grupo controle. Não houve diferença significativa, em relação à LDH, entre o grupo II e o grupo controle. No grupo I, entretanto, houve aumento significativo em relação aos demais. Conclusão: Comparado ao clampeamento contínuo, para um período total de 40 minutos de isquemia, o clampeamento da tríade portal em ratos realizado de forma intermitente, com ciclos de 10 minutos de isquemia e 5 minutos de reperfusão, provoca menor dano hepatocelular, o que foi constatado pela menor alteração enzimática.

    7. Efeitos do óleo de andiroba (Carapa guianensis na função hepática de ratos submetidos à isquemia e reperfusão normotérmica do fígado

      Directory of Open Access Journals (Sweden)

      Nathalya Botelho Brito

      Full Text Available OBJETIVO: avaliar os efeitos do óleo da andiroba (Carapa guianensis na função do fígado de ratos submetidos à isquemia/reperfusão hepática normotérmica. MÉTODOS: foram utilizados 12 ratos Wistar, distribuídos em dois grupos: solução salina (n=6 e andiroba (n=6. O grupo andiroba foi tratado com óleo de andiroba (0,63ml/kg, VO durante sete dias antes do procedimento cirúrgico. A isquemia foi induzida por oclusão da vascularização dos lobos mediano e lateral do fígado, usando clip vascular, nos dois grupos, por 45min, com posterior reperfusão por 60min. Analisaram-se as dosagens de AST, ALT, Gama-GT e biodistribuição hepática do fitato-Tc99m. RESULTADOS:não houve diferença significante no percentual de radioatividade/grama de tecido (%ATI/g no lobo direito do grupo salina (17,53±2,78 quando comparado com o grupo andiroba (18,04±3,52, com p=0,461, o mesmo ocorrendo no %ATI/g do lobo esquerdo do fígado quando os dois grupos foram comparados (p=0,083. No grupo salina o %ATI/g foi significativamente mais elevado no lobo hepático direito não isquemiado (17,53±2,78, em comparação com o lobo esquerdo (5,04±0,82, que sofreu isquemia/reperfusão (p=0,002. Diferença significante também ocorreu na comparação entre os lobos direito (18,04±3,52 e esquerdo (7,11±1,86 dos animais do grupo andiroba (p=0,004. Não houve diferença significante nas dosagens de AST, ALT e Gama-GT comparando-se os dois grupos (p>0,05. CONCLUSÃO:o óleo de andiroba não contribuiu para a proteção da função hepática em modelo de lesão induzida por isquemia e reperfusão normotérmica do fígado de ratos.

    8. Cerebral ischemia caused by Streptococcus bovis aortic endocarditis: case report Isquemia cerebral causada por endocardite aórtica pelo Streptococcus bovis: relato de caso

      Directory of Open Access Journals (Sweden)

      Leopoldo Santos-Neto

      2005-09-01

      Full Text Available Cerebral ischemic processes associated with infective endocarditis caused by Streptococcus bovis are rare; only 2 cases having been reported. Here we report a case of a 50-year-old man with S. bovis endocarditis who presented signs of frontal, parietal and occipital lobe cerebral ischemia. This is the first case reported in which the presence of hemianopsia preceded the endocarditis diagnosis. Initially, the clinical manifestations suggested a systemic vasculitis. Later, vegetating lesions were identified in the aortic valve and S. bovis grew in blood cultures. Antibiotic use and aortic valve replacement eliminated the infection and ceased thromboembolic events. A videocolonoscopy examination revealed no mucosal lesions as a portal of entry in this case, although such lesions have been encountered in up to 70% of reported cases of S. bovis endocarditis.A associação de isquemia cerebral e endocardite por Streptococcus bovis é um evento raro, tendo sido publicados apenas 2 casos anteriormente. Nós relatamos o caso de um homem de 50 anos com endocardite por S. bovis que apresentou sinais isquêmicos nos lobos frontal, parietal e occipital. Este é o primeiro caso em que a hemianopsia precedeu o diagnóstico de endocardite. Inicialmente, o quadro foi confundido com vasculite. Posteriormente, foi confirmada a presença de vegetações na válvula aórtica e a hemocultura identificou S. bovis. Os eventos tromboembólicos foram controlados com o uso de antibióticos e a troca da válvula aórtica. Estudo videocolonoscópico não identificou nenhuma lesão, apesar de lesões colônicas serem descritas em até 70% dos casos de indivíduos com endocardite por S. bovis.

    9. Silent ischemic brain lesions after transcatheter aortic valve replacement : lesion distribution and predictors

      NARCIS (Netherlands)

      Samim, Mariam; Hendrikse, Jeroen; van der Worp, H. Bart; Agostoni, Pierfrancesco; Nijhoff, Freek; Doevendans, Pieter A.; Stella, Pieter R.

      Silent ischemic brain lesions and ischemic stroke are known complications of transcatheter aortic valve replacement (TAVR). We aimed to investigate the occurrence and distribution of TAVR-related silent ischemic brain lesions using diffusion-weighted magnetic resonance imaging (DWI). Consecutive

    10. Morphology and Spelling in French Students with Dyslexia: The Case of Silent Final Letters

      Science.gov (United States)

      Quémart, Pauline; Casalis, Séverine

      2017-01-01

      Spelling is a challenge for individuals with dyslexia. Phoneme-to-grapheme correspondence rules are highly inconsistent in French, which make them very difficult to master, in particular for dyslexics. One recurrent manifestation of this inconsistency is the presence of silent letters at the end of words. Many of these silent letters perform a…

    11. The Keefe Inventory of Silent Reading: A Window into the Reading Process.

      Science.gov (United States)

      Keefe, Donald

      1993-01-01

      Contains part of the Keefe Inventory of Silent Reading, a silent informal reading inventory. Presents a case study of a student to whom it was administered, including analysis of this individual's reading ability and description of the specific strategies used with this individual on the basis of the results of the inventory. (RS)

    12. EFFICACY OF METOPROLOL AND DILTIAZEM IN TREATING SILENT-MYOCARDIAL-ISCHEMIA

      NARCIS (Netherlands)

      PORTEGIES, MCM; SIJBRING, P; GOBEL, JAM; VIERSMA, JW; LIE, KI

      1994-01-01

      Recent studies strongly support the prognostic importance of transient silent ischemia. Because patients with silent ischemia are at higher risk of a cardiac event, they are likely to benefit not only from control of symptoms, but also from treatment directed at prevention of ischemia. The efficacy

    13. Does phonological recoding occur during silent reading and is it necessary for orthographic learning?

      NARCIS (Netherlands)

      de Jong, P.F.; Bitter, D.J.L.; van Setten, M.; Marinus, E.

      2009-01-01

      Two studies were conducted to test the central claim of the self-teaching hypothesis (i.e., phonological recoding is necessary for orthographic learning) in silent reading. The first study aimed to demonstrate the use of phonological recoding during silent reading. Texts containing pseudowords were

    14. (In-)Secure messaging with the Silent Circle instant messaging protocol

      NARCIS (Netherlands)

      Verschoor, S.R.; Lange, T.

      2016-01-01

      Silent Text, the instant messaging application by the company Silent Circle, provides its users with end-to-end encrypted communication on the Blackphone and other smartphones. The underlying protocol, SCimp, has received many extensions during the update to version 2, but has not been subjected to

    15. Distinct transmitter release properties determine differences in short-term plasticity at functional and silent synapses.

      Science.gov (United States)

      Cabezas, Carolina; Buño, Washington

      2006-05-01

      Recent evidence suggests that functional and silent synapses are not only postsynaptically different but also presynaptically distinct. The presynaptic differences may be of functional importance in memory formation because a proposed mechanism for long-term potentiation is the conversion of silent synapses into functional ones. However, there is little direct experimentally evidence of these differences. We have investigated the transmitter release properties of functional and silent Schaffer collateral synapses and show that on the average functional synapses displayed a lower percentage of failures and higher excitatory postsynaptic current (EPSC) amplitudes than silent synapses at +60 mV. Moreover, functional but not silent synapses show paired-pulse facilitation (PPF) at +60 mV and thus presynaptic short-term plasticity will be distinct in the two types of synapse. We examined whether intraterminal endoplasmic reticulum Ca2+ stores influenced the release properties of these synapses. Ryanodine (100 microM) and thapsigargin (1 microM) increased the percentage of failures and decreased both the EPSC amplitude and PPF in functional synapses. Caffeine (10 mM) had the opposite effects. In contrast, silent synapses were insensitive to both ryanodine and caffeine. Hence we have identified differences in the release properties of functional and silent synapses, suggesting that synaptic terminals of functional synapses express regulatory molecular mechanisms that are absent in silent synapses.

    16. Silent Flange Coupling Design Used for the Schenck Eddy Current Dynamometer

      Science.gov (United States)

      Schinteie, D.; Croitorescu, V.

      2016-11-01

      The silent flange used for coupling different machines/systems to an eddy current dynamometer represents one of the modular components each test-bench should use. By introducing a silent flange into a dynamometer, the coupling steps are easier and faster. For an appropriate design, the silent flange was analyzed using dedicated software during different operation procedures and scenarios, for materials that allow easy manufacturing. This study shows that the design for this silent flange model has no danger of failure due to the small deformation and the values for the equivalent stresses. The silent flange coupling is suitable for the dynamometer for his high positioning accuracy, the zero backlash and the fact that there is no motion between the shafts.

    17. Low fetal hemoglobin percentage is associated with silent brain lesions in adults with homozygous sickle cell disease

      OpenAIRE

      Calvet, David; Tuilier, Titien; Mélé, Nicolas; Turc, Guillaume; Habibi, Anoosha; Abdallah, Nassim Ait; Majhadi, Loubna; Hemery, François; Edjlali, Myriam; Galacteros, Frédéric; Bartolucci, Pablo

      2017-01-01

      Low %HbF is independently associated with silent WMCs on brain imaging in adults with SCD.Our results highlight the potential use of therapeutic strategies inducing HbF expression in SCD patients with silent white matter changes.

    18. Soundless Speech/ Wordless Writing: Language and German Silent Cinema

      Directory of Open Access Journals (Sweden)

      Marc Silberman

      2010-12-01

      Full Text Available Speech / Wordless Writing: Language and German Silent Cinema Marc Silberman If language loses its communicative and interpretative functions in direct proportion to the loss of its referential grounding, then the modernist crisis is simultaneously a crisis of its signifying practices. This means that the evolution of the silent cinema is a particularly rich site to examine the problematic relationship of language and image. This essay presents several expressionist films as a specific response to this crisis in order to describe the diverse cinematic forms of resistance to the word, to articulated speech. While some film makers developed the silence of the silent film into a “gestural language” that dramatized light and movement, others reproduced the film figures’ silent speech by means of graphically stylized intertitles. My thesis is that the expressionist cinema maintained an idealistic notion of the film as a pure work of art that aimed at a unified composition of all elements and missed the opportunity to explore the rich semiotic possibilities of the new technological medium with its hybrid, synergetic forms and provocative force. Hence, the expressionist cinema marks a transition or even the endpoint of a long process of reflection about the communicative possibilities of language that shifted to a fundamentally new level with the invention of sound cinema at the end of the 1920s. Parole muette / écriture sans mot: Le langage et le cinéma allemand muet Marc Silberman Le langage, dit-on, perd de ses functions communicatrices et interpretatives en proportion directe à la perte de sa force référentielle. On dira que la crise moderniste est également une crise des pratiques signifiantes. Ce qui revient à dire aussi que l’évolution du cinéma muet serait une site particulièrement riche pour examiner les problématiques du langage vs. l’image. Cet essai présente quelques films expressionnistes comme réactions à la crise

    19. Plasma remediation of trichloroethylene in silent discharge plasmas

      International Nuclear Information System (INIS)

      Evans, D.; Rosocha, L.A.; Anderson, G.K.; Coogan, J.J.; Kushner, M.J.

      1993-01-01

      Plasma destruction of toxins, and volatile organic compounds in particular, from gas streams is receiving increased attention as an energy efficient means to remediate those compounds. In this regard, remediation of trichloroethylene (TCE) in silent discharge plasmas has been experimentally and theoretically investigated. We found that TCE can be removed from Ar/O 2 gas streams at atmospheric pressure with an energy efficiency of 15--20 ppm/(mJ/cm 3 ), or 2--3 kW h kg -1 . The majority of the Cl from TCE is converted to HCl, Cl 2 , and COCl 2 , which can be removed from the gas stream by a water bubbler. The destruction efficiency of TCE is smaller in humid mixtures compared to dry mixtures due to interception of reactive intermediates by OH radicals

    20. Scaling of silent electrical discharge reactors for hazardous organics destruction

      International Nuclear Information System (INIS)

      Coogan, J.J.; Rosocha, L.A.; Brower, M.J.; Kang, M.; Schmidt, C.A.

      1993-01-01

      Silent electrical discharges are used to produce highly reactive free radicals that destroy hazardous compounds entrained in gaseous effluents at ambient gas temperatures and pressures. We have carried out destruction experiments at Los Alamos on a range of volatile organic compounds (VOCs), including trichloroethylene (TCE), carbon tetrachloride, perchloroethylene (PCE), and chlorofluorocarbons (CFCs). We have measured a ''nine-factor'', the amount of energy required to reduce the VOC concentration by a factor of ten. For practical reactor power densities, the ''nine-factor'' can be used to predict the destruction an removal efficiency (DRE) in terms of gas flow rate and the number of reactor modules. This report proposes a modular, stackable architecture for scaling up the reactor throughput

    1. [Silent myocardial ischemia in patients with transient ischemic attacks].

      Science.gov (United States)

      Sánchez Valiente, S; Mostacero, E; del Río, A; Morales, F

      1994-10-01

      Given evidence that ischemic heart disease is the most frequent cause of death in patients with cerebrovascular disease, we used ergometrics to screen 80 patients with TIA for silent myocardial ischemia (SMI) at the neurological unit of Hospital Clínico Universitario in Zaragoza, Spain. The patients were compared with a control group of 80 with no signs of heart disease. Neither the patients nor the controls had ever shown clinical signs of coronary ischemia and their baseline electrocardiograms were normal. Stress test results were positive in 25 (31%) of the TIA patients, and in 4 (5%) (p Hiperlipidemia (75% testing positive versus 43% negative, p < 0.01) and diabetes (31% testing positive versus 13% negative, p < 0.01) were the risk factors statistically related with a positive stress test.

    2. Myocardial perfusion imaging for detection of silent myocardial ischemia

      International Nuclear Information System (INIS)

      Beller, G.A.

      1988-01-01

      Despite the widespread use of the exercise stress test in diagnosing asymptomatic myocardial ischemia, exercise radionuclide imaging remains useful for detecting silent ischemia in numerous patient populations, including those who are totally asymptomatic, those who have chronic stable angina, those who have recovered from an episode of unstable angina or an uncomplicated myocardial infarction, and those who have undergone angioplasty or received thrombolytic therapy. Studies show that thallium scintigraphy is more sensitive than exercise electrocardiography in detecting ischemia, i.e., in part, because perfusion defects occur more frequently than ST depression and before angina in the ischemic cascade. Thallium-201 scintigraphy can be performed to differentiate a true- from a false-positive exercise electrocardiographic test in patients with exercise-induced ST depression and no angina. The development of technetium-labeled isonitriles may improve the accuracy of myocardial perfusion imaging. 11 references

    3. Reducing the silent burden of impaired mental health.

      Science.gov (United States)

      Jané-Llopis, Eva; Anderson, Peter; Stewart-Brown, Sarah; Weare, Katherine; Wahlbeck, Kristian; McDaid, David; Cooper, Cary; Litchfield, Paul

      2011-08-01

      Mental and behavioral disorders account for about one third of the world's disability caused by all ill health among adults, with unipolar depressive disorders set to be the world's number one cause of illhealth and premature death in 2030, affecting high- and low-income countries. There is a range of evidence-based cost-effective interventions that can be implemented in parenting, at schools, at the workplace, and in older age that can promote health and well-being, reduce mental disorders, lead to improved productivity, and increase resilience to cope with many of the stressors in the world. These facts need to be better communicated to policymakers to ensure that the silent burden of impaired mental health is adequately heard and reduced.

    4. Stopping the Silent Killer: Hepatitis B Among Asian Americans

      Centers for Disease Control (CDC) Podcasts

      2008-04-18

      This podcast discusses an underappreciated health threat to many Asians and Pacific Islanders in the United States: chronic infection with the hepatitis B virus. Dr. John Ward, director of CDC's Division of Viral Hepatitis, and Dr. Sam So, founder of the Asian Liver Center at Stanford University, address the importance of testing, vaccination, and care to prevent serious health consequences from this "silent" disease.  Created: 4/18/2008 by National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP), Division of Viral Hepatitis (DVH) and Office of Dispute Resolution and Equal Employment Opportunity, Office of the Director (OD).   Date Released: 5/1/2008.

    5. Treatment of hazardous organic wastes using silent discharge plasmas

      International Nuclear Information System (INIS)

      Rosocha, L.A.; Anderson, G.K.; Bechtold, L.A.; Coogan, J.J.; Heck, H.G.; Kang, M.; McCulla, W.H.; Tennant, R.A.; Wantuck, P.J.

      1992-01-01

      During the past two decades, interest in applying non-equilibrium plasmas to the removal of hazardous chemicals from gaseous media has been growing, in particular from heightened concerns over the pollution of our environment and a growing body of environmental regulations. At the Los Alamos National Laboratory, we are currently engaged in a project to develop non-equilibrium plasma technology for hazardous waste treatment. Our present focus is on dielectric-barrier discharges, which are historically called silent electrical discharges. This type of plasma is also named a silent discharge plasma (SDP). We have chosen this method due to its potential for high energy efficiency, its scientific and technological maturity, and its scalability. The SDP process has been demonstrated to be reliable and economical for the industrial-scale synthesis of ozone, where municipal water treatment plants frequently require the on-site generation of thousands of kilograins per day (Eliasson ampersand Kogelschatz). The related methods of corona processing are presently the focus of work at other institutions, particularly for flue gas processing. Both SDP and corona processes are characterized by the production of large quantities of highly reactive free radicals, especially atomic oxygen O(3P) and the hydroxyl OH, in the gaseous medium and their subsequent reaction with contaminants. Our primary objective is to convert hazardous or toxic chemicals into non-hazardous compounds or into materials which are more amenable to treatment. In the ideal case, the hazardous wastes are destructively oxidized to simpler, non-hazardous compounds plus CO2 and H2O. Sometimes the reaction products are still potentially hazardous, but are easily treated by conventional methods to yield non-hazardous products

    6. Influência do antibiótico nas lesões de isquemia e reperfusão intestinal: estudo experimental em ratos The influence of antibiotics on intestinal ischemia and reperfusion: experimental study in rats

      Directory of Open Access Journals (Sweden)

      Maria de Lourdes Pessole Biondo-Simões

      2000-01-01

      Full Text Available Muito se tem questionado sobre os efeitos da isquemia intestinal seguida de reperfusão (I/R, chamando a atenção para o papel dos leucócitos na patobiologia da I/R. A fisiopatogenia das lesões está intimamente ligada à geração de radicais de oxigênio durante o período em que se processa a reperfusão. A ruptura da barreira intestinal permitindo a translocação bacteriana agravaria ainda mais estas lesões. Este estudo tem por objetivo avaliar as lesões intestinais na vigência de isquemia e na reperfusão com e sem antibioticoterapia. Submeteram-se 42 ratos Wistar à anestesia e laparotomia mediana. Obteve-se isquemia intestinal por clampeamento das artérias mesentéricas cranial e caudal por 30 minutos. Após reperfundiu-se por igual tempo. Metade destes animais receberam 50 mg/kg de eritromicina por via oral nas 24 horas que antecederam o procedimento. Cada um destes grupos foi subdividido em outros 3, constituíndo os subgrupos de controle, isquemia e isquemia/reperfusão. Ao final, ressecaram-se segmentos do intestins delgado para processamento histológico. Avaliaram-se os resultados pela escala de CHIU e col. e submeteram-se os resultados à tratamento estatístico. Observou-se que a mucosa intestinal apresentava-se com padrão normal nos grupos de controle, tanto com antibioticoprofilaxia como sem. Os intestinos submetidos à isquemia com ou se antibioticoprofilaxia mostraram, lesões com descolamento e perda de vilosidades até infartamento transmucoso. Os intestinos reperfundidos apresentavam lesões semelhantes. Verificou-se que os intestinos reperfundidos que receberam antibioticoprofilaxia apresentavam lesões mais graves do que os que sofreram isquemia sem antibioticoprofilaxia (p=0,0303. Concluiu-se que o uso de antibióticos pré-isquemia não diminui a gravidade das lesões histopatológicas da mucosa intestinal, não protegendo das lesões após a reperfusão.The role of the white blood cells in the ischemia and

    7. A antibioticoterapia prévia sobre o infiltrado inflamatório pulmonar após isquemia e reperfusão intestinal: estudo experimental em ratos

      Directory of Open Access Journals (Sweden)

      Biondo-Simões Maria de Lourdes Pessole

      2000-01-01

      Full Text Available A isquemia seguida de reperfusão intestinal (I/R é um evento clínico comum que favorece a translocação bacteriana em órgãos à distância, como os pulmões. A antibioticoterapia prévia pode ser uma conduta eficaz para atenuar o desenvolvimento desse processo. Este esudo tem por finalidade reconhecer a concentração dos polimorfonucleares (PMN nos septos alveolares em ratos, após indução de isquemia seguida de reperfusão intestinal, com e sem antibioticoterapia prévia. Utilizaram-se 48 ratos divididos, aleatoriamente em 6 grupos (A,B,C,D,E,Fcom 8 animais cada um. Os grupos A,C e E não receberam antibiótico,e os grupos B, D e F receberam 500mg/Kg de eritromicina por via oral. Os grupos A e B serviram de controle; C e D induziu-se isquemia intestinaL por 30 min; e os grupos E e F seguiu-se à isquemia, reperfusão por 30 min. Em seguida, abriu-se o tórax e ressecaram-se os pulmões, sendo encaminhados para análise histopatológica e histométrica, obtendo-se uma média de PMN nos septos alvéolos. O grupo controle(A apresentou média de 4,2 PMN campo nos septos; o grupo isquêmico(C, 13,6 e o reperfundido (E, 17,5. A comparação entre as médias dos grupos A e C e A e E tiveram p<0,0001. Entretanto, a comparação entre os grupos C e E não foi significante (p=0,095. A média de PMN por campo foi de 8,6 no grupo B; 9,9 no grupo D e 12,9 no grupo F. A comparação entre os grupos B e D teve p=0,007. A comparação entre os grupos que receberam ou não antibiótico permitiu verificar que o número de PMN do grupo B foi o dobro do grupo A (p=0,004. O grupo C apresentou maior concentração de PMN que o grupo D (p=0,019. No grupo E, houve maior concentração de PMN que no grupo F (p=0,014. Pode-se concluir que: (1 a isquemia intestinal levou a maior concentração de PMN nos septos alveolares; (2 a antibioticoterapia prévia aumentou o infiltrado inflamatório pulmonar nos alvéolos dos ratos com intestino normal; (3 nos septos

    8. Migraine with aura and silent brain infarcts lack of mediation of patent foramen ovale.

      Science.gov (United States)

      Calviere, L; Tall, P; Massabuau, P; Bonneville, F; Larrue, V

      2013-12-01

      Population-based studies have shown a heightened prevalence of clinically silent brain infarcts in subjects who have migraine with aura (MA). We sought to determine whether this association could be confirmed in young patients with cryptogenic ischemic stroke, and explored the role of patent foramen ovale (PFO) as a potential underlying mechanism. Patients were selected from a registry of young patients consecutively treated for ischemic stroke in a tertiary university hospital among those without definite cause of stroke. Patients with PFO were matched for age and gender with patients with normal atrial septum. Migraine and MA were evaluated after patient selection and matching. Silent brain infarcts were independently evaluated on MRI. We included 100 patients [60 men; mean age (SD), 44.8 years (8.3)], 50 patients with PFO. We found silent brain infarcts in 36 patients and MA in 13 patients. MA was more frequent in patients with silent brain infarcts than in patients without silent brain infarcts (25.0% vs. 6.3%; OR, 5; 95% CI, 1.4-17.6; P = 0.01). Traditional cardiovascular risk factors were not associated with silent brain infarcts. PFO was neither associated with MA (OR, 1.7; 95% CI, 0.5-5.3) nor silent brain infarcts (OR, 0.7; 95% CI, 0.3-1.5). The association of MA with silent brain infarcts was not altered after adjustment for PFO. Findings suggest that silent brain infarcts in young patients with cryptogenic stroke is associated with MA. We found no evidence for a mediating effect of PFO on this association. © 2013 The Author(s) European Journal of Neurology © 2013 EFNS.

    9. Screening for silent myocardial ischemia caseof diabetics : interest of myocardial perfusion scintigraphy

      International Nuclear Information System (INIS)

      Bahri, Haifa

      2007-01-01

      Silent myocardial ischemia is a major cause of morbidity and mortality in diabetic patients. Its diagnosis by noninvasive means such as myocardial SPECT would improve the management of these patients. The purpose of this study is to assess the frequency of silent myocardial ischemia in asymptomatic diabetics and their evolution. As a result, the myocardial SPECT is a reliable tool for screening for silent myocardial ischemia in diabetic patients. Its prognostic value allows to stratify the cardiac risk and guide therapeutic management. Its integration into a screening strategy in Tunisia seems limited by its low availability and cost. The latter could be reduced by better patient selection.

    10. Silent ischemia in patients after the acute myocardial infarction

      International Nuclear Information System (INIS)

      Samarzija, M.

      1991-01-01

      The purpose of this study was to determine the frequency and importance of silent ischemia in patients (pts) after acute myocardial infarction (AMI) as well as to establish diagnostic and prognostic values of exercise stress test (EST), Holter (H) monitoring and thallium-201 (Tl) scintigraphy. All the tests were performed 2-4 months following the AMI. The criterion for diagnostic myocardial ischemia on EST and H is 1 mm or more of horizontal or down-sloping ST depression. Additional criteria for Holter imply that the ischemic episode should last one minute and be separated from other episodes by at least one minute. Planar thallium images were performed 5-10 minutes after the stress test; the delayed images were obtained after 3-6 hours. Visual and quantitative methods were employed in the analysis of Tl-scintigraphy. Scintigraphy was considered positive if exercise-induced perfusion defects showed redistribution. The study included 74 asymptomatic patients after the AMI. The patients were divided into two groups by results of quantitative Tl-scintigraphy: Group I - 44 pts with silent ischemia, Group II - 30 pts without ischemia. In Group I, out of 44 pts, 9 had a positive exercise stress test, 4 showed a painless ST depression on Holter and 7 had both tests positive, whereas 24 pts had only scintigraphy positive. In Group II one patient had positive EST and H. Sensitivity and specificity were determined by results of coronary arteriography performed on 33 pts: EST (Se=40%, Sp=80%), H (Se=21%, Sp=100%) and scintigraphy (Se=93%, Sp=80%). During the follow-up period lasting at least 12 months, in Group I 3 pts died, 1 developed a new myocardial infarction and 15 pts had painful ischemic occurrences. In Group II only 3 pts developed symptoms of angina pectoris. Tl-scintigraphy was the only non-invasive test showing significant correlation with the follow-up outcomes. The diagnostic and prognostic superiority of Tl-scintigraphy justifies its value as an initial

    11. Silent ischemia in patients after uncomplicated myocardial infarction

      International Nuclear Information System (INIS)

      Samarzija, M.; Tezak, S.

      1994-01-01

      The purpose of this study was to determine the frequency and importance of silent ischemia in patients (pts) after the acute myocardial infarction (A MI) as well as to establish diagnostic and prognostic value of exercise stress test (EST), Holter (H) monitoring and thallium-201 (Tl) scintigraphy. All the three tests were performed 2-4 months following the AMI. The criterion for diagnosing myocardial ischemia on EST and H is 1 mm or more of horizontal or down-sloping ST depression. Additional criteria for Holter imply the ischemic episode should last one minute and be separated from other episodes by at least one minute. Planar thallium images were performed 5-10 minute after the stress test; the delayed images were obtained after 3-6 hours. Visual and quantitative methods were employed in the analysis of TI-scintigraphy. Scintigraphy was considered positive if exercise- induced perfusion defects showed redistribution. The study included 74 asymptomatic patients after the AMI. The patients were divided into two groups by results of quantitative Tl-scintigraphy: Group I - 44 pts with silent ischemia, Group II - 30 pts without ischemia. In Group I, out of 44 pts, 9 had a positive exercise stress, 4 showed a painless ST depression on Holter and 7 had both tests positive, whereas 24 pts had only scintigraphy positive. In Group II one patient had positive EST and H. Sensitivity and specificity were determined by results of coronary arteriography performed on 33 pts: EST (Se=40%, Sp=80%), H (Se=219, Sp=100%) and scintigraphy (Se=93%, Sp =80%). During the follow-up period lasting at least 12 months, in Group I 3 pts died, 1 developed a new myocardial infarction and 15 pts had painful ischemic occurrences. In Group II only 3 pts developed symptoms of angina pectoris. Tl-scintigraphy was the only non-invasive test showing significant correlation with the follow-up outcomes. The diagnostic and prognostic superiority of Tl-scintigraphy justifies its value as the initial

    12. Silent angels the genetic and clinical aspects of Rett syndrome

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      Dziwota Ewelina

      2016-12-01

      Full Text Available Rett syndrome is a neurodevelopmental genetic disorder and, because of some behavioral characteristics, individuals affected by the disease are known as silent angels. Girls with Rett syndrome perform stereotyped movements, they have learning difficulties, their reaction time is prolonged, and they seem alienated in the environment. These children require constant pediatric, neurological and orthopedic care. In the treatment of Rett syndrome physical therapy, music therapy, hydrotherapy, hippotherapy, behavioral methods, speech therapy and diet, are also used. In turn, psychological therapy of the syndrome is based on the sensory integration method, using two or more senses simultaneously. In 80% of cases, the syndrome is related to mutations of the MECP2 gene, located on chromosome X. The pathogenesis of Rett syndrome is caused by the occurrence of a non-functional MeCP2 protein, which is a transcription factor of many genes, i.e. Bdnf, mef2c, Sgk1, Uqcrc1. Abnormal expression of these genes reveals a characteristic disease phenotype. Clinical symptoms relate mainly to the nervous, respiratory, skeletal and gastrointestinal systems. Currently causal treatment is not possible. However, researchers are developing methods by which, perhaps in the near future, it will be possible to eliminate the mutations in the MECP2 gene, and this will give a chance to the patient for normal functioning.

    13. The silent mass extinction of insect herbivores in biodiversity hotspots.

      Science.gov (United States)

      Fonseca, Carlos Roberto

      2009-12-01

      Habitat loss is silently leading numerous insects to extinction. Conservation efforts, however, have not been designed specifically to protect these organisms, despite their ecological and evolutionary significance. On the basis of species-host area equations, parameterized with data from the literature and interviews with botanical experts, I estimated the number of specialized plant-feeding insects (i.e., monophages) that live in 34 biodiversity hotspots and the number committed to extinction because of habitat loss. I estimated that 795,971-1,602,423 monophagous insect species live in biodiversity hotspots on 150,371 endemic plant species, which is 5.3-10.6 monophages per plant species. I calculated that 213,830-547,500 monophagous species are committed to extinction in biodiversity hotspots because of reduction of the geographic range size of their endemic hosts. I provided rankings of biodiversity hotspots on the basis of estimated richness of monophagous insects and on estimated number of extinctions of monophagous species. Extinction rates were predicted to be higher in biodiversity hotspots located along strong environmental gradients and on archipelagos, where high spatial turnover of monophagous species along the geographic distribution of their endemic plants is likely. The results strongly support the overall strategy of selecting priority conservation areas worldwide primarily on the basis of richness of endemic plants. To face the global decline of insect herbivores, one must expand the coverage of the network of protected areas and improve the richness of native plants on private lands.

    14. Silent Sinus Syndrome: A Retrospective Review of 11 Cases

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      Karima DARGHAL

      2014-06-01

      Full Text Available Objective: The purpose of this study is to describe the clinical and radiological features of SSS, and to review therapeutic possibilities and their outcomes.Patients and Methods: Retrospective observational case series in the department of Arthur Vernes Institute between Mars 2007 and  Novembre 2012. Clinical records, including ophthalmology and otolaryngology evaluations as well as computed tomography scans and operative reports, were carefully examined. A literature review for relevant studies was performed to examine similar cases.Results: Eleven cases of  SSS were identified. Nine men and two women (sex ratio 4.5, aged between 23 and 54 years (mean, 30 years. there was 3 to 4 mm enophthalmos in 10 cases (90.9%, and hypoglobus in all cases, with no effect on visual function. In all 11 cases, the maxillary roof (orbital floor was drawn downwards, and the one or more walls of the maxilla were concave. In 4 cases septal deviation was present. 8 patients (72.7% underwent endoscopic sinus surgery, while 3 refused it. Septoplasty was performed in 4 cases (36.3%.Conclusion: The silent sinus syndrome is a rare entity. It mainly presents as unilateral enophthalmos in younger people and has very characteristic clinical and radiologic signs.This case series reports our diagnostic and therapeutic experience with this syndrome.

    15. Silent Spring, the 50th anniversary of Rachel Carson's book.

      Science.gov (United States)

      Pimentel, David

      2012-09-27

      David Pimentel is a professor of ecology and agricultural sciences at Cornell University, Ithaca, NY 14853-0901. His Ph.D. is from Cornell University and had postdoctoral research at the University of Chicago, MIT, and fellowship at Oxford University (England). He was awarded a distinguished honorary degree from the University of Massachusetts. His research spans the fields of energy, population ecology, biological pest control, pesticides, sustainable agriculture, land and water conservation, livestock, and environmental policy. Pimentel has published more than 700 scientific papers and 37 books and has served on many national and government committees including the National Academy of Sciences; President's Science Advisory Council; U.S Department of Agriculture; U.S. Department of Energy; U.S. Department of Health, Education and Welfare; Office of Technology Assessment of the U.S. Congress; and the U.S. State Department. He is currently Editorial Advisor for BMC Ecology. In this article, he reflects on 50 years since the publication of Rachel Carson's influential book, Silent Spring.

    16. Sonographically determined clues to the symptomatic or silent cholelithiasis

      International Nuclear Information System (INIS)

      Saba, S.; Iqbal, Z.

      2007-01-01

      To determine an association between sonographically determined contractility with the symptomatic or silent nature of gallstone. Adult gallstone patients without (group I) and with biliary symptoms (group II) were compared with age and gender-matched controls. Demographic data, body mass index, risk factors, size, number and mobility of gallstone, gallbladder wall thickness (GBWT), volume and Ejection Fraction (EF) were determined on ultrasound before and after a standardized fatty meal (BFM and AFM). Demographic data, risk factors and gallstone characteristics were analyzed by Pearson Chi-square test and the gallbladder characteristics were analyzed by One-way ANOVA and Post Hoc tests by multiple comparisons on SPSS 11 with significance p=0.05. The gallbladder contractility as measured by changes in wall thickness and volume changes BFM and AFM, and ejection fraction was similar in controls and asymptomatic cholelithiasis groups and significantly reduced in symptomatic patients (p<.001). Multiparity (p=0.002), female gender (p=0.018), age less than 50 years (0.05), impacted calculi (p=0.001), multiple calculi (<.001) and calculi 5 mm (p<0.001) were associated with pain. A sluggishly emptying gallbladder was more significantly associated with symptomatic cholelithiasis compared to controls and asymptomatic cholelithiasis state in this series. Consideration of age, gender, impaction of calculi, number and size of calculi is important in causing symptom state and management options. (author)

    17. Construction of the Cylindrical Ozone Generator by Silent Discharge Method

      International Nuclear Information System (INIS)

      Agus Purwadi; Widdi Usada; Suryadi; Isyuniarto; Sri Sukmajaya

      2002-01-01

      It has been constructed the ozone generator by silent discharge method. Anode and cathode of discharge tube were made of stainless steel (SS) in the cylinder form with diameters of 22 mm and 25 mm, the length of 100 mm and 110 mm, the equal thickness of 1 mm respectively. The dielectric was made of cylinder glass with diameter of 23 cm, the length of 105 cm and the thickness of 1 mm. The testing of apparatus was carried out by using discharge voltage of 12.5 kV and frequency of 1.5 kHz. Identification of the ozone gas formation was marked by the existing of special ozone smell and the separated of iodine molecule (yellow colour) from the potassium iodide solution which contaminated gas out put from the ozonizer. By using absorbing method can be shown that the ozone production rate was 0.196 mg/s by using oxygen gas input and 0.065 mg/s by using ordinary air input. (author)

    18. Silent Aortic Dissection Presenting as Transient Locked-In Syndrome

      Science.gov (United States)

      Nadour, Wadih; Goldwasser, Brian; Biederman, Robert W.; Taffe, Kevin

      2008-01-01

      Acute aortic dissection is a medical emergency. Without prompt recognition and treatment, the mortality rate is high. An atypical presentation makes timely diagnosis difficult, especially if the patient is experiencing no characteristic pain. Many patients with aortic dissection are reported to have presented with various neurologic manifestations, but none with only a presentation of transient locked-in syndrome. Herein, we report a case of completely painless aortic dissection in a woman who presented with a transient episode of anarthria, quadriplegia, and preserved consciousness. On physical examination, she had a 40-point difference in blood pressure between her left and right arms, and a loud diastolic murmur. The diagnosis of acute aortic dissection was reached via a combination of radiography, computed tomography, echocardiography, and a high index of clinical suspicion. The patient underwent emergency surgery and ultimately experienced a successful outcome. To our knowledge, this is the 1st report of aortic dissection that presented solely as locked-in syndrome. We suggest that silent aortic dissection be added to the differential diagnosis for transient locked-in syndrome. PMID:18941610

    19. Agreement of the silent partnership – tax and legal consequences of its conclusion and execution

      OpenAIRE

      Monika Zieniewicz

      2016-01-01

      The institution of the silent partnership is not currently regulated by any legal act in the Polish legal system, although its importance in practice is not in doubt. As every action made in the economic sphere and economic execution of the contract is associated with specific effects on the basis of the tax laws. However, due to the lack of statutory regulation of the institution of silent partnership problematic is the question of determining the effects of tax legislation. Therefore, speci...

    20. Quiste dermoide intracraneal con rotura espontánea. Reporte de caso

      Directory of Open Access Journals (Sweden)

      Leonardo Andrés Chacón-Zambrano

      2017-04-01

      Full Text Available Introducción: Los quistes dermoides son tumores raros, que se originan por la inclusión de elementos de origen ectodérmico en el momento del cierre del tubo neural durante la embriogénesis. Su contenido incluye una variedad de derivados del ectodermo como glándulas apocrinas, sudor, quistes sebáceos, folículos pilosos, epitelio escamoso y dientes. Los síntomas que generan estos tumores benignos son tanto por el efecto de masa sobre las estructuras neurovasculares adyacentes (cefalea, convulsiones, hidrocefalia, isquemia, como por la irritación meníngea en los casos de ruptura hacia el espacio subaracnoideo. Objetivo: Presentar el curso clínico de paciente femenino de 21 años de edad, que acude a la consulta de neurocirugía con clínica de cefalea y síncope. Presentación del caso: Paciente con rotura espontánea de un quiste dermoide intracraneal que consultaba previamente por clínica de cefalea, a la cual se asocia más recientemente episodios de alteración de la conciencia, realizándose estudio de neuroimágenes con evidencia de quiste dermoide intracraneal roto, el cual fue manejado quirúrgicamente con resolución exitosa de la sintomatología. Conclusiones: Se considera relevante el caso teniendo en cuenta lo inusual de la patología según la epidemiología consultada, además este reporte de caso, permite sensibilizar al personal de salud sobre esta patología tumoral la cual puede llegar a la cura en caso de resección quirúrgica completa, con resolución de la clínica.

    1. The written voice: implicit memory effects of voice characteristics following silent reading and auditory presentation.

      Science.gov (United States)

      Abramson, Marianne

      2007-12-01

      After being familiarized with two voices, either implicit (auditory lexical decision) or explicit memory (auditory recognition) for words from silently read sentences was assessed among 32 men and 32 women volunteers. In the silently read sentences, the sex of speaker was implied in the initial words, e.g., "He said, ..." or "She said...". Tone in question versus statement was also manipulated by appropriate punctuation. Auditory lexical decision priming was found for sex- and tone-consistent items following silent reading, but only up to 5 min. after silent reading. In a second study, similar lexical decision priming was found following listening to the sentences, although these effects remained reliable after a 2-day delay. The effect sizes for lexical decision priming showed that tone-consistency and sex-consistency were strong following both silent reading and listening 5 min. after studying. These results suggest that readers create episodic traces of text from auditory images of silently read sentences as they do during listening.

    2. Cintilografia miocárdica com estresse mental na investigação de dor torácica Centellograma miocárdico con estrés mental en la investigación de dolor torácico Radionuclide imaging of myocardium with mental stress in the investigation of thoracic pain

      Directory of Open Access Journals (Sweden)

      Lívia Maria Lima da Silva

      2009-10-01

      Full Text Available A dor torácica é um sintoma comum nos serviços de emergência e a cintilografia de estresse representa uma das etapas da estratificação de risco nesses indivíduos. Entretanto, um grupo de pacientes com exames funcionais negativos após o estresse físico ou farmacológico desenvolve isquemia miocárdica durante estresse mental. As alterações do tônus vascular em resposta a mecanismos endógenos são a base fisiopatológica dessas alterações. Relata-se um caso que ilustra como a cintilografia de estresse mental tem o potencial para ser utilizada na avaliação de isquemia miocárdica, não detectada pelos métodos convencionais, em pacientes com suspeita de dor torácica isquêmica.El dolor torácico es un síntoma común en los servicios de emergencia y el centellograma de estrés representa una de las etapas de la estratificación de riesgo en estos individuos. No obstante, un grupo de pacientes con exámenes funcionales negativos después del estrés físico o farmacológico desarrolla isquemia miocárdica durante el estrés mental. Las alteraciones del tono vascular en respuesta a mecanismos endógenos son la base fisiopatológica de estas alteraciones. Se relata un caso que ilustra cómo el centellograma de estrés mental tiene potencial para ser utilizado en la evaluación de isquemia miocárdica, no detectada por los métodos convencionales, en pacientes con sospecha de dolor torácico isquémico.Thoracic pain is a common symptom in emergency services, and stress radionuclide imaging represents one of the phases of risk stratification in these individuals. However, a group of patients with negative functional exams after physical or pharmacological stress develops myocardial ischemia during this psychological stress. Alterations in vascular tonus as a response to endogenous mechanisms are the physiopathologic basis for such alterations. We report a case that illustrates how mental stress radionuclide imaging has the potential to

    3. Effect of liver ischemic preconditioning in cirrhotic rats submitted to hepatic ischemia/reperfusion injury Efeito do pré-condicionamento isquêmico hepático submetidos a lesão de isquemia/reperfusão do fígado

      Directory of Open Access Journals (Sweden)

      Eduardo Garcia Pacheco

      2006-01-01

      Full Text Available PURPOSE: The main aim of this study was to determine the influence of ischemic preconditioning (IPC on rat liver cirrhosis. METHODS: Cirrhosis was induced in Wistar rats by occlusion of the hepatic duct. The animals were divided into four groups of six animals each: non-cirrhotic group (simulated operation only, cirrhotic control group (simulated operation in cirrhotic rats, I/R group (40-minute ischemia without IPC, and IPC group (cirrhotic rats with ischemia, previously submitted to IPC. The IPC procedure consisted of partial hepatic ischemia for five minutes, followed by 10 minutes of reperfusion. In the case of the IPC group, the animals were submitted to liver ischemia for 40 minutes after the preconditioning procedure, followed by 2 hours of reperfusion. Blood samples were collected for measurement of serum aminotransferases (ALT and AST. The respiratory control ratio (RCR, the mitochondrial membrane potential (MMP, and malondialdehyde (MDA values in the hepatic tissue were analyzed. Nonparametric statistical analysis was used and a value of pOBJETIVO: O objetivo deste estudo foi determinar a influência do pré-condicionamento isquêmico (IPC em fígados de ratos cirróticos. MÉTODOS: A cirrose hepática foi induzida em ratos Wistar machos (250 a 300g por oclusão, durante 30 dias, do ducto hepático comum.A seguir, os animais cirróticos foram divididos em três grupos de seis; Grupo controle cirrótico (operação simulada para isquemia/reperfusão/pré-condicionamento, Grupo I/R, isquemia de 40 minutos sem pré-condicionamento (IPC e grupo IPC com isquemia precedida por IPC. O IPC consistiu de uma isquemia parcial por cinco minutos, seguida por 10 minutos de reperfusão. No grupo IPC, após o pré-condicionamento, os animais foram submetidos à isquemia hepática de 40 minutos seguida de 2 horas de reperfusão. Foram colhidas amostras de sangue para dosagem sérica de aminotransferases (ALT e AST. Razão de controle respiratório (RCR

    4. Effect of short-term ornithine alpha-ketoglutarate pretreatment on intestinal ischemia-reperfusion in rats Efeitos do pré-tratamento em curto prazo com ornitina alfa-cetoglutarato na isquemia-reperfusão intestinal em ratos

      Directory of Open Access Journals (Sweden)

      Eduardo Silvio Gouveia Gonçalves

      2011-01-01

      Full Text Available PURPOSE: To investigate the effects of preventive enteral administration of ornithine alpha-ketoglutarate (OKG in an ischemia-reperfusion rat model. METHODS: Sixty rats were randomized into five groups (G1-G5, n = 12. Each group was divided into two subgroups (n = 6 and treated with calcium carbonate (CaCa or OKG by gavage. Thirty minutes later, the animals were anesthetized with xylazine 15mg + ketamine 1mg ip and subjected to laparotomy. G1-G3 rats served as controls. Rats in groups G4 and G5 were subjected to ischemia for 30 minutes. Ischemia was achieved by clamping the small intestine and its mesentery, delimiting a segment of bowel 5 cm long and 5 cm apart from the ileocecal valve. In addition, G5 rats underwent reperfusion for 30 minutes. Blood samples were collected at the end of the laparotomy (G1, after 30 minutes (G2, G4 and 60 minutes (G3, G5 to determine concentrations of metabolites (pyruvate, lactate, creatine phosphokinase (CPK, thiobarbituric acid reactive substances (TBARS and glutathione (GSH. RESULTS: There was a significant decrease in tissue pyruvate and lactate and plasma CPK levels in OKG-treated rats at the end of reperfusion period. GSH levels did not change significantly in ischemia and reperfusion groups. However, TBARS levels increased significantly (pOBJETIVO: Investigar os efeitos da administração enteral preventiva de ornitina alfa-cetoglutarato (OKG em modelo de isquemia-reperfusão no rato. MÉTODOS: Sessenta ratos foram randomizados em cinco grupos (G1-G5, n=12. Cada grupo foi redistribuído em dois subgrupos (n=6 e tratado com carbonato de cálcio (CaCa ou OKG por gavagem. Trinta minutos mais tarde, os animais foram anestesiados com xilazina 1mg+cetamina 15mg i.p. e submetidos à laparotomia. Os ratos dos grupos G4-G5 foram submetidos à isquemia por 30 minutos. A isquemia foi obtida por pinçamento do intestino delgado, delimitando um segmento com 5 cm de comprimento e distando 5 cm da válvula ileocecal. O

    5. Influence of limb temperature on cutaneous silent periods.

      Science.gov (United States)

      Kofler, Markus; Valls-Solé, Josep; Vasko, Peter; Boček, Václav; Štetkárová, Ivana

      2014-09-01

      The cutaneous silent period (CSP) is a spinal inhibitory reflex mediated by small-diameter afferents (A-delta fibers) and large-diameter efferents (alpha motoneurons). The effect of limb temperature on CSPs has so far not been assessed. In 27 healthy volunteers (11 males; age 22-58 years) we recorded median nerve motor and sensory action potentials, median nerve F-wave and CSPs induced by noxious digit II stimulation in thenar muscles in a baseline condition at room temperature, and after randomly submersing the forearm in 42 °C warm or 15 °C cold water for 20 min each. In cold limbs, distal and proximal motor and sensory latencies as well as F-wave latencies were prolonged. Motor and sensory nerve conduction velocities were reduced. Compound motor and sensory nerve action potential amplitudes did not differ significantly from baseline. CSP onset and end latencies were more delayed than distal and proximal median nerve motor and sensory latencies, whereas CSP duration was not affected. In warm limbs, opposite but smaller changes were seen in nerve conduction studies and CSPs. The observed CSP shift "en bloc" towards longer latencies without affecting CSP duration during limb cooling concurs with slower conduction velocity in both afferent and efferent fibers. Disparate conduction slowing in afferents and efferents, however, suggests that nociceptive EMG suppression is mediated by fibers of different size in the afferent than in the efferent arm, indirectly supporting the contribution of A-delta fibers as the main afferent input. Limb temperature should be taken into account when testing CSPs in the clinical setting, as different limb temperatures affect CSP latencies more than large-diameter fiber conduction function. Copyright © 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

    6. Immunological profile of silent brain infarction and lacunar stroke.

      Directory of Open Access Journals (Sweden)

      Paola Sarchielli

      Full Text Available Neuroinflammation is believed to be involved in the pathophysiological mechanisms of silent brain infarcts (SBI. However, the immunological profile of SBI has been scarcely investigated. In the context of a national research project named SILENCE, aimed at investigating clinical, biochemical and pathogenic features of SBI, we have measured the plasma profile of some inflammatory-related molecules in SBI patients (n = 21, patients with recent lacunar infarcts (LI, n = 28 and healthy controls (n = 31, consecutively enrolled in four Italian centres. A panel of chemokines (MIG, CTACK, IL16, SDF1a, MCP1, growth factors (SCF, SCGFb, HGF, IL3, immunoglobulin-type adhesion molecules (ICAM1, VCAM1, proinflammatory cytokines (IL18, INFa2, MIF, IL12p40, cell surface receptors on T-cells (IL2Ra, and inductors of apoptosis (TRAIL was assessed in plasma samples by Luminex xMAP™ technology. Immunological parameters were compared using non-parametric statistics and performance to distinguish SBI and LI was evaluated by receiver operating characteristic (ROC analysis. Plasma levels of ICAM1 were significantly higher in both SBI and LI patients as compared to controls (SBI≥LI>Ctrl. A different trend was observed for IL16 (SBICtrl, SCF (LICtrl and SCGFb (SBI>LICtrl and IL18 when compared to LI patients (Ctrl≤SBI>LI. All the other immunological markers did not significantly differ among groups. According to ROC analysis, the best predictor for SBI condition was the chemokine MIG (AUC = 0.84, sensitivity 86%, specificity 77%, while SCF had the best performance in distinguishing LI patients (AUC = 0.84, sensitivity 86%, specificity 68%. These results confirm the involvement of inflammatory processes in cerebrovascular disorders, particularly in SBI, a very common age-related condition. The differences in plasma profile of inflammatory molecules may underlie different pathological mechanisms in SBI and LI patients.

    7. Mass media effect on vaccines uptake during silent polio outbreak.

      Science.gov (United States)

      Sagy, Iftach; Novack, Victor; Gdalevich, Michael; Greenberg, Dan

      2018-03-14

      During 2013, isolation of a wild type 1 poliovirus from routine sewage sample in Israel, led to a national OPV campaign. During this period, there was a constant cover of the outbreak by the mass media. To investigate the association of media exposure and OPV and non-OPV vaccines uptake during the 2013 silent polio outbreak in Israel. We received data on daily immunization rates during the outbreak period from the Ministry of Health (MoH). We conducted a multivariable time trend analysis to assess the association between daily media exposure and vaccines uptake. Analysis was stratified by ethnicity and socio-economic status (SES). During the MoH supplemental immunization activity, 138,799 OPV vaccines were given. There was a significant association between media exposure and OPV uptake, most prominent in a lag of 3-5 days from the exposure among Jews (R.R 1.79C.I 95% 1.32-2.41) and high SES subgroups (R.R 1.71C.I 95% 1.27-2.30). These subgroups also showed increased non-OPV uptake in a lag of 3-5 days from the media exposure, in all vaccines except for MMR. Lower SES and non-Jewish subgroups did not demonstrate the same association. Our findings expand the understanding of public behaviour during outbreaks. The public response shows high variability within specific subgroups. These findings highlight the importance of tailored communication strategies for each subgroup. Copyright © 2018 Elsevier Ltd. All rights reserved.

    8. Left ventricular function abnormalities as a manifestation of silent myocardial ischemia.

      Science.gov (United States)

      Lambert, C R; Conti, C R; Pepine, C J

      1986-11-01

      A large body of evidence exists indicating that left ventricular dysfunction is a common occurrence in patients with severe coronary artery disease and represents silent or asymptomatic myocardial ischemia. Such dysfunction probably occurs early in the time course of every ischemic episode in patients with coronary artery disease whether symptoms are eventually manifested or not. The pathophysiology of silent versus symptomatic left ventricular dysfunction due to ischemia appears to be identical. Silent ischemia-related left ventricular dysfunction can be documented during spontaneous or stress-induced perturbations in the myocardial oxygen supply/demand ratio. It also may be detected by nitroglycerin-induced improvement in ventricular function or by salutary changes in wall motion following revascularization. Silent left ventricular dysfunction is a very early occurrence during ischemia and precedes electrocardiographic abnormalities. In this light, its existence should always be kept in mind when dealing with patients with ischemic heart disease. It can be hypothesized that because silent ischemia appears to be identical to ischemia with symptoms in a pathophysiologic sense, prognosis and treatment in both cases should be the same.

    9. Clinical study of correlation of pre-senile and senile depressive stage with silent cerebral infarction

      International Nuclear Information System (INIS)

      Fujikawa, Tokumi; Yamawaki, Shigeto; Fujita, Yasunobu; Shibata, Youko; Touhouda, Yoshikuni.

      1992-01-01

      The relationship between the pre-senile/senile depressive state and silent cerebral infarction was examined by MRI. Consecutive 56 depressive patients aged 50 years or older underwnt MRI. MRI revealed silent cerebral infarction in 60.3% of patients in whom depression occurred at the age of less than 65 years. The complication rate was significantly higher in these patients than the younger patients (60.9% vs 20%). Complications of silent cerebral infarction were found in 53.6% for patients in whom depression occurred at the age of less than 65 years and symptoms were deteriorated at the age of 65 years or older and in 100% for patients in whom it occurred at the age of 65 years or older and hospitalization was simultaneously required. These figures were remarkably higher than the age-related complication rate of silent cerebral infarction in non-depressive normal persons. This suggested that approximately half of depressive patients of pre-senile onset and majority of depressive patients of senile onset might have parenchymal involvement due to silent cerebral infarction. Both perforating-type and cortical-type infarcts were found. This has a implication for the involvement of multiple infarct-related foci in depressive state. For cortical-type infarcts, partial lesions were predominant, followed by frontal and temporal lesions. The incidence of left frontal infarcts was significanly higher than that of right frontal infarcts. Infarcts in both the parietal and left frontal lobes may be responsible for depressive state. (N.K.)

    10. The Right to Remain Silent in Criminal Trial

      Directory of Open Access Journals (Sweden)

      Gianina Anemona Radu

      2013-05-01

      Full Text Available A person's right not to incriminate oneself or to remain silent and not contribute to their own incrimination is a basic requirement of due process, although the right not to testify against oneself is not expressly guaranteed. This legal right is intended to protect the accused/ the defendant against the authorities’ abusive coercion. The scope of the right not to incriminate oneself is related to criminal matter under the Convention, and thus susceptible or applicable to criminal proceedings concerning all types of crimes as a guarantee to a fair trial. The European Court of Justice ruled that despite the fact that art. 6 paragraph 2 of the Convention does not expressly mention the right not to incriminate oneself and the right not to contribute to their own incrimination (nemo tenetur are ipsum accusare these are generally recognized international rules that are in consistence with the notion of “fair trial” stipulated in art. 6. By virtue of the right to silence, the person charged with a crime is free to answer the questions or not, as he/she believes it is in his/her interest. Therefore, the right to silence involves not only the right not to testify against oneself, but also the right of the accused/ defendant not to incriminate oneself. Thus, the accused/defendant cannot be compelled to assist in the production of evidence and cannot be sanctioned for failing to provide certain documents or other evidence. Obligation to testify against personal will, under the constraint of a fine or any other form of coercion constitutes an interference with the negative aspect of the right to freedom of expression which must be necessary in a democratic society. It is essential to clarify certain issues as far as this right is concerned. First of all, the statutory provision in question is specific to adversarial systems, which are found mainly in Anglo-Saxon countries and are totally different from that underlying the current Romanian Criminal

    11. Efeito do módulo de inativação leucocitária (LIM) na distribuição de 99mTc-granulócitos em porcos submetidos à circulação extracorpórea e à isquemia-reperfusão de coração e pulmões

      OpenAIRE

      Francischetti, Ieda [UNESP

      2010-01-01

      O uso da circulação extracorpórea desencadeia uma resposta inflamatória sistêmica, que somada às reações em cadeia relacionadas à isquemia-reperfusão de coração e pulmões pode levar a lesões celulares e até falência de órgãos no pós-operatório de cirurgia cardíaca. Vários estudos foram feitos visando melhor entendimento desses processos inflamatórios associados à circulação extracorpórea. Assim, esta revisão abordará os mecanismos de isquemia-reperfusão cardiopulmonar a ativação da cascata in...

    12. STUDY OF IMMUNITY TO POLIOVIRUSES ON CERTAIN "SILENT" TERRITORIES OF RUSSIA

      Directory of Open Access Journals (Sweden)

      N. I. Romanenkova

      2011-01-01

      Full Text Available Abstract. The degree of immunity to polioviruses of three serotypes among children of different ages was analysed on certain "controlled" and "silent" territories of Russia in different periods of Polio Eradication Initiative. It was shown that the levels of immunity of children’s population to polioviruses on "controlled" and "silent" territories had no significant difference. It was stated that on the phase which preceded the certification for the absence of circulation of wild polioviruses, when the National Immunisation Days were conducted in the country, the percentage of eronegative children to polioviruses of different serotypes was low on all the territories of Russia. After Russia as a part of the WHO European region was certified as a polio free country and mass immunisation was stopped thepercentage of seronegative children increased, especially to poliovirus of serotype 3, both on the "controlled" and on the "silent" territories.

    13. Agreement of the silent partnership – tax and legal consequences of its conclusion and execution

      Directory of Open Access Journals (Sweden)

      Monika Zieniewicz

      2016-12-01

      Full Text Available The institution of the silent partnership is not currently regulated by any legal act in the Polish legal system, although its importance in practice is not in doubt. As every action made in the economic sphere and economic execution of the contract is associated with specific effects on the basis of the tax laws. However, due to the lack of statutory regulation of the institution of silent partnership problematic is the question of determining the effects of tax legislation. Therefore, special attention is needed to determine the issue of these effects on the basis of income tax, tax on goods and services, transfer tax and the tax on inheritance and donations, as well as the question of liability for the tax liabilities of the silent partnership.

    14. The clinical dilemma of "silent desensitization" in aspirin-exacerbated respiratory disease.

      Science.gov (United States)

      White, Andrew A; Bosso, John V; Stevenson, Donald D

      2013-01-01

      Aspirin desensitization is a treatment option for patients with aspirin-exacerbated respiratory disease (AERD). Some patients with an excellent history of aspirin or nonsteroidal anti-inflammatory drug (NSAID) reactions have negative aspirin challenges/desensitization. This study discusses the clinical entity of silent desensitization in AERD and the dilemma that this presents to the practicing allergist/immunologist. We discuss a series of patients with a strong history of NSAID reactions who initially underwent a negative challenge/silent desensitization. These patients were subsequently proven to have AERD after a second positive aspirin challenge. Silent desensitization is an uncommon but important outcome to recognize in AERD. Clinicians performing aspirin desensitization should understand that this can occur and consider a second confirmatory aspirin challenge in some patients.

    15. Um novo modelo para estudos sobre lesão de isquemia e reperfusão hepáticas em cães A new canine model for studies on hepatic ischaemia and reperfusion injury

      Directory of Open Access Journals (Sweden)

      Renato Dornelas Câmara Neto

      2000-06-01

      Full Text Available A lesão de isquemia e reperfusão hepáticas que ocorre no transplante de fígado não está completamente elucidada. Vários modelos experimentais com objetivo de estudos fisiopatológico e de modulação farmacológica desta condição têm sido propostos. Um desses modelos, proposto para cães, compreende a isquemia de 30% da massa hepática com descompressão portal translobar através dos restantes 70% de parênquima hepático. No presente trabalho, 10 cães foram submetidos à desvascularização de uma maior massa hepática (70%, seguida de reperfusão, com descompressão venosa esplâncnica através dos lobos caudado e lateral direito (30% (Grupo Teste, durante o período de isquemia. Dez outros cães foram submetidos à operação simulada (Grupo Controle. Os resultados indicaram com um grau de confiança de 95% que: 1. Durante o período de isquemia verificou-se estabilização da PAM e da PVC, elevação da pressão portal (PP semelhante à desenvolvida com o uso de "bypass", diminuição significativa da temperatura corporal(TC sem atingir níveis médios aquém de 36oC, ausência de acidose metabólica ou aumento dos níveis de enzimas (AST, ALT e DL, presença de necrose hepática (NH e queda do conteúdo de glicogênio hepático (CGH; 2. Após a reperfusão do fígado constatou-se queda da PAM, ausência de diferenças significativas de PVC , permanência de níveis elevados de PP, decréscimo da TC, presença de acidose metabólica (¯ pH, ¯ DB, aumento significativo e progressivo de aminotransferases (AST, ALT, desidrogenase láctica (DL e necrose hepática (NH, bem como declínio progressivo do conteúdo de glicogênio hepático (CGH. Os resultados sugerem que o modelo proposto pode ser útil para estudos de fisiopatologia e de modulação farmacológica da lesão de isquemia e reperfusão do fígado, utilizando uma maior massa hepática.Hepatic ischaemia and reperfusion injury, as seen during hepatic transplantation, has not

    16. A Comparison of Reading Rates, Comprehension, and Stamina in Oral and Silent Reading of Fourth-Grade Students

      Science.gov (United States)

      Trainin, Guy; Hiebert, Elfrieda H.; Wilson, Kathleen M.

      2015-01-01

      This study examined the relationships between silent and oral reading fluency and comprehension. Findings indicated that fourth grade students had consistent levels of comprehension in both reading modes. Students of all reading levels showed a similar pattern across the segments of a text set in both oral and silent reading--a gradual increase in…

    17. Silent infarction on a second CT scan in 91 patients without manifest stroke in the Dutch TIA trial

      NARCIS (Netherlands)

      Herderscheê, D.; Hijdra, A.; Algra, A.; Kappelle, L. J.; Koudstaal, P. J.; van Gijn, J.

      1994-01-01

      The frequency of silent infarction is an important issue because it is a marker of vascular disease. We studied the occurrence of silent infarction in a sample of patients from the Dutch TIA trial, in which patients were randomized between 30 and 283 mg of aspirin. A total of 91 patients with TIA or

    18. Paciente con trombocitopenia trombótica inducida por heparina en hemodiálisis: abordaje de la anticoagulación del circuito

      Directory of Open Access Journals (Sweden)

      Mirian García Martínez

      Full Text Available Resumen El tratamiento renal sustitutivo de hemodiálisis es una técnica de depuración sanguínea extraterrenal, que requiere proteger al circuito extracorpóreo del paciente. Actualmente la heparina es el anticoagulante endovenoso de elección para evitar este tipo de complicaciones intradiálisis, siendo necesaria la individualización de las dosis por paciente. La trombocitopenia trombótica inducida por heparina es uno de los posibles efectos secundarios producidos por la administración de heparina. La bivalirudina es un inhibidor directo y específico de la trombina, útil en diferentes procedimientos, siendo utilizado en pacientes con problemas con la heparina y con fracaso renal crónico terminal que requieren terapias de diálisis continuas. Caso clínico: Paciente de 46 años, con múltiples antecedentes personales. Al inicio de su proceso debutó con una Gangrena de Fournier secundaria a isquemia de extremidades inferiores, por lo que precisó tratamiento anticoagulante. Hasta la fecha no presentó alergias medicamentosas conocidas. Posteriormente se objetivó plaquetopenia progresiva con diagnóstico de trombocitopenia inducida por heparina tipo II por lo que se restringió la heparina de bajo peso molecular y la heparina sódica, indicándose anticoagulación con Sintrom y Bivalirudina en casos de procedimientos con alto riesgo de sangrado. Conclusiones: Los pacientes de hemodiálisis en nuestro hospital, tienen como pauta habitual de anticoagulación la heparina. En este caso el diagnostico precoz de la trombocitopenia trombótica inducida por la heparina, fue crucial para evitar daños mayores, siendo el equipo de enfermería la piedra angular en el tratamiento en la sala de hemodiálisis.

    19. Improvement of ozone yield by a multi-discharge type ozonizer using superposition of silent discharge plasma

      International Nuclear Information System (INIS)

      Song, Hyun-Jig; Chun, Byung-Joon; Lee, Kwang-Sik

      2004-01-01

      In order to improve ozone generation, we experimentally investigated the silent discharge plasma and ozone generation characteristics of a multi-discharge type ozonizer. Ozone in a multi-discharge type ozonizer is generated by superposition of a silent discharge plasma, which is simultaneously generated in separated discharge spaces. A multi-discharge type ozonizer is composed of three different kinds of superposed silent discharge type ozonizers, depending on the method of applying power to each electrode. We observed that the discharge period of the current pulse for a multi discharge type ozonizer can be longer than that of silent discharge type ozonizer with two electrodes and one gap. Hence, ozone generation is improved up to 17185 ppm and 783 g/kwh in the case of the superposed silent discharge type ozonizer for which an AC high voltages with a 180 .deg. phase difference were applied to the internal electrode and the external electrode, respectively, with the central electrode being grounded.

    20. Expression of HSP70 in cerebral ischemia and neuroprotetive action of hypothermia and ketoprofen Expressão de HSP70 na isquemia cerebral e a ação neuroprotetora da hipotermia e do cetoprofeno

      Directory of Open Access Journals (Sweden)

      Daniela Pretti da Cunha Tirapelli

      2010-08-01

      Full Text Available Heat shock proteins (HSPs are molecular chaperones that bind to other proteins to shepherd them across membranes and direct them to specific locations within a cell. Several injurious stimuli can induce Hsp70 expression, including ischemia. This study aimed to investigate the pattern of expression of protein (immunohistochemistry and gene (real-time PCR Hsp70 in experimental focal cerebral ischemia in rats by occlusion of the middle cerebral artery for 1 hour and the role of neuroprotection with hypothermia (H and ketoprofen (K. The infarct volume was measured using morphometric analysis defined by triphenyl tetrazolium chloride. It was observed increases in the protein (p=0.0001 and gene (p=0.0001 Hsp70 receptor in the ischemic areas that were reduced by H (protein and gene: pProteínas de choque térmico (HSPs são chaperones moleculares que se ligam a outras proteínas para atravessar as membranas e encaminhá-las para locais específicos dentro de uma célula. Vários estímulos nocivos podem induzir a expressão de Hsp70, incluindo isquemia. Este estudo teve como objetivo investigar o padrão de expressão protéica (imunohistoquímica e gênica (PCR em tempo real de Hsp70 na isquemia cerebral focal experimental em ratos pela oclusão da artéria cerebral média durante 1 hora e o papel da neuroproteção com hipotermia (H e cetoprofeno (C. O volume de infarto foi calculado através da análise morfométrica definido por cloreto de trifenil tetrazólio. Foi observado aumento na expressão proteína (p=0,0001 e gênica (p=0,0001 de Hsp70 nas áreas isquêmicas que foram reduzidas pela H (proteína e gene: p<0,05, C (proteína: p<0,001 e H+K (proteína: p<0,01 e gene: p<0,05. O aumento de Hsp70 na área isquêmica sugere que a neuroexcitotoxicidade mediada pela Hsp70 desempenha um papel importante na morte celular e que o efeito neuroprotetor tanto da H quanto do C está diretamente envolvido com a Hsp70.

    1. Avaliação de dois modelos experimentais de isquemia e reperfusão cerebral em ratos com oclusão temporária carotídea associada ou não à oclusão vertebral

      Directory of Open Access Journals (Sweden)

      Tardini Daniela Mazza Sundefeld

      2003-01-01

      Full Text Available OBJETIVO: Avaliar a reprodutibilidade de dois modelos experimentais de isquemia e reperfusão cerebral. MÉTODOS: 60 ratos foram distribuídos, aleatoriamente, em três grupos experimentais, com 20 animais cada: I - pinçamento temporário de artéria carótida esquerda; II - cauterização prévia das artérias vertebrais e pinçamento temporário da artéria carótida esquerda; simulado - sem isquemia nem reperfusão. Todos os animais tiveram oclusão definitiva de artéria carótida direita e os três grupos foram subdivididos em dois períodos de reperfusão: A - 60 minutos e B - 120 minutos. Os parâmetros verificados foram: medidas de pressão arterial média sistêmica e fluxo sangüíneo carotídeo; medida de malondialdeído cerebral através do teste TBARS e avaliação histológica do hemisfério cerebral submetido à isquemia e reperfusão. Foi feito também um estudo complementar com angiografia cerebral em 5 animais adicionais. RESULTADOS: Não houve diferenças significativas nas dosagens de malondialdeído cerebral e na freqüência e gravidade das alterações histológicas cerebrais entre os três grupos. Nos grupos GI e GII, a PAM foi significantemente maior no período de isquemia. O fluxo sangüíneo entre os períodos pré e pós-pinçamento aumentou nos grupos IA e IIB, diminuiu no grupo IB e no grupo IIA manteve-se inalterado. As angiografias do estudo complementar mostraram aporte sangüíneo para cérebro através de circulação colateral. CONCLUSÃO: Os modelos de isquemia e reperfusão estudados não demonstraram alterações consistentes de marcadores de lesão cerebral, seja quanto à produção de lipoperóxidos ou de lesões histológicas.

    2. Paciente con esquizofrenia tratado con ziprasidona + clozapina

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      Pol Yanguas E.

      2013-05-01

      Full Text Available P es un paciente diagnosticado de esquizofrenia, sigue en un piso tutelado un programa de rehabilitación, está medicado con clozapina 500 mg/día y ziprasidona 280 mg/ día. Padece hipercolesterolemia, tabaquismo y sus hábitos alimenticios no son buenos. La medicación que utiliza desde 2007 hasta ahora se refleja en la tabla 1. El último tratamiento se le introdujo el 7 de agosto de 2012, habiendo presentado un electro cardiograma (ECG normal, pero con ligera taquicardia ventricular y prolactinemia de 44,8 ng/ml (valores normales: 2-18 ng/ml.

    3. Dual silent communication system development based on subvocal speech and Raspberry Pi

      Directory of Open Access Journals (Sweden)

      José Daniel Ramírez-Corzo

      2016-09-01

      Additionally, in this article we show the speech subvocal signals’ recording system realization. The average accuracy percentage was 72.5 %, and includes a total of 50 words by class, this is 200 signals. Finally, it demonstrated that using the Raspberry Pi it is possible to set a silent communication system, using subvocal. speech signals.

    4. Silent hepatitis E virus infection in Dutch blood donors, 2011 to 2012

      NARCIS (Netherlands)

      Slot, E.; Hogema, B. M.; Riezebos-Brilman, A.; Kok, T. M.; Molier, M.; Zaaijer, H. L.

      2013-01-01

      In Europe, the dynamics of endemic hepatitis E virus (HEV) infection remain enigmatic. We studied the presence of silent HEV infection among Dutch blood donors. Using donations collected throughout the Netherlands in 2011 and 2012, 40,176 donations were tested for HEV RNA in 459 pools of 48 or 480

    5. The Effect of Background Music While Silent Reading on EFL Learners’ Reading Comprehension

      Directory of Open Access Journals (Sweden)

      sakineh sahebdel

      2014-05-01

      Full Text Available This study attempted to determine the effect of background music while silent reading on Iranian EFL learners’ reading comprehension. The participants were 57 Iranian EFL learners between the ages of 14 and 16 in two 3rd grade high schoolclasses at pre-intermediate proficiency level. Before treatment,both experimental and control groups took a reading comprehension pretest. In the experimental group, the researchers played Mozart sonatas as background music and asked them to read the passage silently and then answer the reading comprehension questions. In the control group, the procedure was the same, but no music was played while silent reading by the students. After ten sessions, the students of both groups were asked to answer another independent but parallel form of reading section of PET as their post-test. The independent samples t-testresultsindicated that the experimental group outperformed the control group in reading comprehension posttest, and listening to background music while silent reading had a significantly positive effect on Iranian EFL learners’ reading comprehension. The results of the present study have implications for EFL students, teachers, and teacher educators as well as syllabus designers and materials developers.

    6. Characterisation of silent and active genes for a variable large protein of Borrelia recurrentis

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      Scragg Ian G

      2002-10-01

      Full Text Available Abstract Background We report the characterisation of the variable large protein (vlp gene expressed by clinical isolate A1 of Borrelia recurrentis; the agent of the life-threatening disease louse-borne relapsing fever. Methods The major vlp protein of this isolate was characterised and a DNA probe created. Use of this together with standard molecular methods was used to determine the location of the vlp1B. recurrentis A1 gene in both this and other isolates. Results This isolate was found to carry silent and expressed copies of the vlp1B. recurrentis A1 gene on plasmids of 54 kbp and 24 kbp respectively, whereas a different isolate, A17, had only the silent vlp1B. recurrentis A17 on a 54 kbp plasmid. Silent and expressed vlp1 have identical mature protein coding regions but have different 5' regions, both containing different potential lipoprotein leader sequences. Only one form of vlp1 is transcribed in the A1 isolate of B. recurrentis, yet both 5' upstream sequences of this vlp1 gene possess features of bacterial promoters. Conclusion Taken together these results suggest that antigenic variation in B. recurrentis may result from recombination of variable large and small protein genes at the junction between lipoprotein leader sequence and mature protein coding region. However, this hypothetical model needs to be validated by further identification of expressed and silent variant protein genes in other B. recurrentis isolates.

    7. Origin of the low-level EMG during the silent period following transcranial magnetic stimulation

      DEFF Research Database (Denmark)

      Butler, Jane E; Petersen, Nicolas C; Herbert, Robert D

      2012-01-01

      OBJECTIVE: The cortical silent period refers to a period of near silence in the electromyogram (EMG) after transcranial magnetic stimulation (TMS) of the motor cortex during contraction. However, low-level EMG of unknown origin is often present. We hypothesised that it arises through spinal...

    8. Silent Films and Strange Stories: Theory of Mind, Gender, and Social Experiences in Middle Childhood

      Science.gov (United States)

      Devine, Rory T.; Hughes, Claire

      2013-01-01

      In this study of two hundred and thirty 8- to 13-year-olds, a new "Silent Films" task is introduced, designed to address the dearth of research on theory of mind in older children by providing a film-based analogue of F. G. E. Happe's (1994) Strange Stories task. Confirmatory factor analysis showed that all items from both tasks loaded…

    9. Veratridine activates a silent sodium-channel in rat isolated aorta

      NARCIS (Netherlands)

      WERMELSKIRCHEN, D; WILFFERT, B; NEBEL, U; LEIDIG, A; WIRTH, A; Peters, Thies

      1992-01-01

      To investigate the existence of silent Na+ channels, isolated rat aorta was treated with veratridine (0.1 mM) and the resulting Ca2+ uptake was determined. After 30-min incubation the total tissue uptake of Ca2+ and Ca2+ uptake increased from 2.325 +/- 0.017 to 2.614 +/- 0.080 nmol/mg wet weight

    10. Cervical Cancer as a silent killer: A rare case report with review of literature

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      Deeksha Pandey

      2015-01-01

      Full Text Available Advanced-stage cervical cancer almost always presents either with abnormal vaginal bleeding or with foul-smelling vaginal discharge. We present here a rare case, where a postmenopausal lady presented almost silently with stage IVA cervical cancer. Fortunately, timely referral, correct diagnosis, and multispecialty team work could save her life.

    11. Direct and Indirect Effects of Print Exposure on Silent Reading Fluency

      Science.gov (United States)

      Mano, Quintino R.; Guerin, Julia M.

      2018-01-01

      Print exposure is an important causal factor in reading development. Little is known, however, of the mechanisms through which print exposure exerts an effect onto reading. To address this gap, we examined the direct and indirect effects of print exposure on silent reading fluency among college students (n = 52). More specifically, we focused on…

    12. BOOK REVIEW: ARE YOU AN ADVOCATE, TACIT SUPPORTER, CRITICAL SKEPTIC, OR SILENT SKEPTIC?

      Science.gov (United States)

      "Silent Sperm," "You're not half the man your grandfather was," "Assault on the Male," "Gender Benders,"-perhaps no other public health concern has given rise to the number of memorable sound bites than has the issue of whether environmental contaminants are causing adverse healt...

    13. Measuring the cortical silent period can increase diagnostic confidence for amyotrophic lateral sclerosis.

      NARCIS (Netherlands)

      Schelhaas, H.J.; Arts, I.M.P.; Overeem, S.; Houtman, C.J.; Janssen, H.; Kleine, B.U.; Munneke, M.; Zwarts, M.J.

      2007-01-01

      We evaluated a modified measurement of the cortical silent period (CSP) as a simple procedure to add further confidence in the diagnostic work-up for ALS. Thirty-seven consecutive patients with a suspicion of having ALS were included together with 25 healthy volunteers, and followed until a final

    14. Definition dependent properties of the cortical silent period in upper-extremity muscles, a methodological study

      NARCIS (Netherlands)

      Kuijk, A.A. van; Bakker, C.D.; Hendriks, J.C.M.; Geurts, A.C.; Stegeman, D.F.; Pasman, J.W.

      2014-01-01

      BACKGROUND: To explore if stimulus-response (S-R) characteristics of the silent period (SP) after transcranial magnetic stimulation (TMS) are affected by changing the SP definition and by changing data presentation in healthy individuals. This information would be clinically relevant to predict

    15. Definition dependent properties of the cortical silent period in upper-extremity muscles, a methodological study

      NARCIS (Netherlands)

      van Kuijk, A.A.; Bakker, C,; Hendriks, J.J.A.; Geurts, A.H.; Stegeman, D.F.; Pasman, J.W.

      2014-01-01

      Background: To explore if stimulus-response (S-R) characteristics of the silent period (SP) after transcranial magnetic stimulation (TMS) are affected by changing the SP definition and by changing data presentation in healthy individuals. This information would be clinically relevant to predict

    16. Neural responses to silent lipreading in normal hearing male and female subjects

      NARCIS (Netherlands)

      Ruytjens, Liesbet; Albers, Frans; van Dijk, Pim; Wit, Hero; Willemsen, Antoon

      In the past, researchers investigated silent lipreading in normal hearing subjects with functional neuroimaging tools and showed how the brain processes visual stimuli that are normally accompanied by an auditory counterpart. Previously, we showed activation differences between males and females in

    17. Scintigraphic diagnosis of silent aspiration following double-sided lung transplantation

      International Nuclear Information System (INIS)

      Toenshoff, G.; Stock, U.; Bohuslavizki, K.H.; Brenner, W.; Costard-Jaeckle, A.; Cremer, J.; Clausen, M.

      1996-01-01

      We present a case of a 25 year old patient who underwent double-sided lung transplantation and suffered from recurrent pneumonia. Silent aspiration was suspected clinically. Aspiration was proved by scintigraphy enabling to discriminate between direct oro-pulmonal aspiration and aspiration after gastro-esophageal reflux. (orig.) [de

    18. Whatever Happened to the Silent Scientific Revolution?--Research, Theory and Practice in Distance Education.

      Science.gov (United States)

      Morgan, Alistair

      The point of departure for this article is the title of a book edited by David Fetterman, "Qualitative Approaches to Educational Evaluation--The Silent Scientific Revolution." This article addresses the question of how the shift to a qualitative, phenomenological approach has impinged on research and evaluation in distance education.…

    19. Silent Atrial Fibrillation in Elderly Pacemaker Users: A Randomized Trial Using Home Monitoring.

      Science.gov (United States)

      Lima, Ceb; Martinelli, M; Peixoto, G L; Siqueira, S F; Wajngarten, Maurício; Silva, Rodrigo Tavares; Costa, Roberto; Filho, Roberto; Ramires, José Antônio Franchini

      2016-05-01

      Pacemaker with remote monitoring (PRM) may be useful for silent atrial fibrillation (AF) detection. The aims of this study were to evaluate the incidence of silent AF, the role of PRM, and to determine predictors of silent AF occurrence. Three hundred elderly patients with permanent pacemaker (PPM) were randomly assigned to the remote group (RG) or control group (CG). All patients received PPM with remote monitoring capabilities. Primary end point was AF occurrence rate and the secondary end points were time to AF detection and number of days with AF. During the average follow-up of 15.7±7.7 months, AF episodes were detected in 21.6% (RG = 24% vs CG = 19.3%, P = 0.36]. There was no difference in the time to detect the first AF episode. However, the median time to detect AF recurrence in the RG was lower than that in the CG (54 days vs 100 days, P = 0.004). The average number of days with AF was 16.0 and 51.2 in the RG and CG, respectively (P = 0.028). Predictors of silent AF were left atrial diameter (odds ratio [OR] 1.2; 95% CI = 1.1-1.3; P pacemaker; left atrial diameter and diastolic dysfunction were predictors of its occurrence. AF monitoring by means of pacemaker is a valuable tool for silent AF detection and continuous remote monitoring allows early AF recurrence detection and reduces the number of days with AF. © 2015 Wiley Periodicals, Inc.

    20. Isquemia cerebral como manifestación inicial de un mixoma atrial izquierdo: Reporte de un caso Brain ischemia as initial sign of a left atrial myxoma: Report of one case

      Directory of Open Access Journals (Sweden)

      Luis F Osio

      2008-04-01

      Full Text Available Los tumores primarios del corazón son raros; 75% de éstos son benignos y cerca de la mitad de los benignos son mixomas que, en la mayoría de los casos, se encuentran en las cavidades izquierdas. Las manifestaciones clínicas de los mixomas dependen del sitio de localización del tumor. Sin embargo, se afirma que la isquemia cerebral es la manifestación clínica inicial en un tercio de los mixomas atriales. Se presenta el caso de un paciente de género masculino, de 65 años de edad, en quien la primera manifestación clínica de mixoma atrial fue un evento cerebral vascular isquémico.Primary heart tumors are rare; 75% of them are benign and almost half of the benign ones are mixomas that in most cases are located in the left cavities. Clinical manifestations of myxomas depend on its localization site. Nevertheless, it is accepted that brain ischemia is the initial clinical manifestation in a third of atrial myxomas. The case of a 65 years old male patient in whom the first clinical manifestation of an atrial myxoma was an ischemic cerebrovascular event, is presented.

    1. Efeito protetor da criocardioplegia cristalóide na isquemia global e reperfusão durante circulação extracorpórea: um mecanismo dependente do endotélio?

      Directory of Open Access Journals (Sweden)

      ÉVORA Paulo Roberto B

      1997-01-01

      Full Text Available Estudos prévios demonstraram que o comprometimento da produção de EDRF/NO mediada por receptores, após isquemia global e reperfusão, possa ser devido a uma disfunção de G-proteínas que liga os receptores da célula endotelial à via da síntese de EDRF/NO. O presente trabalho experimental sugere que a criocardioplegia cristalóide, associada a hipotermia tópica, previne ou pode reverter, em parte, a disfunção endotelial nas mesmas condições. Mais estudos serão necessários para conclusões mais definitivas, pois as análises estatísticas mais acuradas sugeriram aumento da amostragem. Este detalhe talvez seja devido às grandes dificuldades de uniformização relacionada a este tipo de experimentos. Além disso, demonstrou-se pela primeira vez que a hipotermia, por si só, pode estimular a liberação de EDRF/NO pelo endotélio vascular. Isto sugere que o endotélio possa ser um importante sensor de mudanças da temperatura sangüínea e tem importantes implicações para o entendimento da fisiologia da CEC e dos mecanismos locais de auto-regulação.

    2. Terapia trombolítica en pacientes con infarto agudo de miocardio en Cienfuegos

      Directory of Open Access Journals (Sweden)

      Lázaro Abilio Hernández Rodríguez

      2014-03-01

      Full Text Available Fundamento: el tratamiento trombolítico practicado a menos de dos horas, tras el inicio del infarto tiene resultados similares a la reperfusión mecánica. Objetivo: describir aspectos relevantes de la terapia trombolítica en pacientes con infarto agudo de miocardio con elevación del segmento ST en Cienfuegos. Métodos: estudio descriptivo, prospectivo, en 225 pacientes egresados (vivos y fallecidos desde el 1o de abril de 2012 al 31 marzo de 2013, de la Unidad de Cuidados Integrales del Corazón y la Unidad de Cuidados Intensivos Polivalentes, del Hospital Dr. Gustavo Aldereguía Lima. Las variables estudiadas se obtuvieron de la revisión de las historias clínicas e incluyeron: variables demográficas y clínicas, tiempos de demora, sitio, motivo de exclusión y nivel de prioridad para la trombolisis. Resultados: la media de edad superó los 60 años. Predominaron los hombres, hipertensos y de alto riesgo según la escala GRACE. El 29,7 % de los pacientes no recibió terapia trombolítica, debido mayormente al factor tiempo y la mayoría (82,3 % se trató en el Hospital. Las medianas de los tiempos de demora: síntomas-puerta, puerta-droga y síntomas-droga fueron 90, 35 y 140 minutos respectivamente. Conclusiones: la trombolisis extrahospitalaria acorta el tiempo total de isquemia, pero pocos pacientes se beneficiaron de ella. Los retrasos para la terapia trombolítica en Cienfuegos continúan por encima de los estándares requeridos.

    3. Videojuego con Realidad Virtual

      OpenAIRE

      González Mora, César

      2017-01-01

      El objetivo del proyecto es el desarrollo de un videojuego deportivo que utilice realidad mixta. El videojuego se podrá utilizar con dispositivos de tipo cardboard, y utilizará realidad aumentada para la interacción del jugador con el videojuego. En el desarrollo se utilizará el motor Unity para conseguir una aplicación multiplataforma, y la librería Vuforia para implementar realidad mixta.

    4. Sistemas integrados con Arduino

      OpenAIRE

      EL YAKOUTI, MOHAMMED

      2017-01-01

      Design of a robot prototype remotely controllable from Bluetooth using Arduino. Control and testing of sensors and events interacting with Arduino and Bluetooth. Diseño de un prototipo de robot controlable remotamente con Bluetooth utilizando Arduino. Control y verificación de los sensores y eventos que interactúan mediante el Arduino y el Bluetooth. El Yakouti, M. (2017). Sistemas integrados con Arduino. http://hdl.handle.net/10251/89274. TFGM

    5. An investigation of the reduction of carbon dioxide in a silent electric discharge

      Science.gov (United States)

      Luce, R. S.; Greenough, B. (Editor)

      1978-01-01

      The reduction of CO2 to O2 and CO in a silent electric discharge was studied. It was found that current alone (in the ionized plasma induced by the silent electric discharge) was reponsible for the CO2 reduction process. Voltage and frequency were important only in so far as they induced current in the plasma. Pressure and temperature were of minimum influence in the process. The large power consumption in the process was recognized as resulting from the low power factor of the reactor vessel which electrically behaved like a capacitor. The power factor was subsequently improved by adding an inductive element to make the reactor vessel capacitance part of a resonant circuit. It was found that the CO2 reduction process was most efficient in terms of power vs reduction rate when a voltage was employed that was only slightly higher than that needed to induce the plasma.

    6. When Spiders Bite: The Use, Misuse, and Unintended Consequences of ``Silent Information''

      Science.gov (United States)

      Keenan, Thomas P.

      Spiders are the workhorses of the Internet, silently (and almost invisibly) traversing the online world, 24 hours a day, looking for information that may be of interest to someone. It is being archived, organized, and sold, usually without the knowledge or consent of the subject of the information. Serious consequences are starting to appear, such as the withdrawal of three candidates from the October 2008 Canadian Federal election because of previous online indiscretions. While these were intentional if mis-guided postings, information made available without our consent can have equally devastating effects. Advances in artificial intelligence, as well as the increasing tendency to post more and more information, such as videos, will make the gathering, aggregation, and republishing of this “silent information” an increasingly important issue that must be addressed from the technical, social, ethical and legal perspectives, and sooner rather than later.

    7. Dynamic wind turbine models in power system simulation tool DIgSILENT

      DEFF Research Database (Denmark)

      Hansen, Anca Daniela; Iov, F.; Sørensen, Poul Ejnar

      , connection of the wind turbine at different types of grid and storage systems. Different control strategies have been developed and implemented for these wind turbine concepts, their performance in normal or fault operation being assessed and discussed by means of simulations. The described control......This report presents a collection of models and control strategies developed and implemented in the power system simulation tool PowerFactory DIgSILENT for different wind turbine concepts. It is the second edition of Risø-R-1400(EN) and it gathers and describes a whole wind turbine model database...... of the interaction between the mechanical structure of the wind turbine and the electrical grid during different operational modes. The report provides thus a description of the wind turbines modelling, both at a component level and at a system level. The report contains both the description of DIgSILENT built...

    8. Typical and atypical (silent) subacute thyroiditis in a wife and husband

      International Nuclear Information System (INIS)

      Morrison, J.; Caplan, R.H.

      1978-01-01

      Typical subacute thyroiditis was diagnosed in a woman. Three weeks later, signs and symptoms of hyperthyroidism developed in her husband. Although the right lobe of his thyroid gland was slightly enlarged, pain and tenderness were absent throughout the course of his illness. The free thyroxine equivalent (FTE) value and the sedimentation rate were elevated; the low uptake of radioactive iodine by the thyroid gland was consistent with ''silent'' subacute thyroiditis. We postulate that a common etiology, probably viral, was operative in both cases. Nine additional cases of hyperthyroidism with low levels of thyroidal uptake of radioactive iodine are described. The thyroid glands of these patients were normal or slightly enlarged. Antithyroglobulin antibody levels determined in seven patients were not substantially elevated. The clinical course of these patients was characteristic of ''silent'' subacute thyroiditis. Although the origin of the syndrome remains unclear, the disease is self-limited and therapy, if any, is supportive

    9. Typical and atypical (silent) subacute thyroiditis in a wife and husband

      Energy Technology Data Exchange (ETDEWEB)

      Morrison, J.; Caplan, R.H.

      1978-01-01

      Typical subacute thyroiditis was diagnosed in a woman. Three weeks later, signs and symptoms of hyperthyroidism developed in her husband. Although the right lobe of his thyroid gland was slightly enlarged, pain and tenderness were absent throughout the course of his illness. The free thyroxine equivalent (FTE) value and the sedimentation rate were elevated; the low uptake of radioactive iodine by the thyroid gland was consistent with ''silent'' subacute thyroiditis. We postulate that a common etiology, probably viral, was operative in both cases. Nine additional cases of hyperthyroidism with low levels of thyroidal uptake of radioactive iodine are described. The thyroid glands of these patients were normal or slightly enlarged. Antithyroglobulin antibody levels determined in seven patients were not substantially elevated. The clinical course of these patients was characteristic of ''silent'' subacute thyroiditis. Although the origin of the syndrome remains unclear, the disease is self-limited and therapy, if any, is supportive.

    10. Psychosis and Silent Celiac Disease in a Down Syndrome Adolescent: A Case Report

      Directory of Open Access Journals (Sweden)

      Amparo Morant

      2011-01-01

      Full Text Available Celiac disease is an autoimmune systemic disorder. It presents gastrointestinal and nongastrointestinal manifestations as well as associated conditions. We report a 16-year-old Down syndrome girl who presented psychosis symptomatology, and she was diagnosed as having silent celiac disease. Olanzapine treatment and gluten-free diet were satisfactory. It is necessary to consider celiac disease in Down syndrome patients with psychiatric symptoms, mainly psychotic symptomatology.

    11. Silent reading of music and texts; eye movements and integrative reading mechanisms

      OpenAIRE

      Cara, Michel André; Gómez, Gabriela

      2016-01-01

      This study investigates to what extent structural units defined by physical and structural markers elicit different eye movement patterns when reading contrasting stimuli of music and verbal texts. Eye movements were tracked and compared in ten musicians undergoing Bachelor’s degrees as they silently read six texts and six pieces of music for piano: the music was contemporary, in modal style, and the style of the texts was informative and literary. Participants were music students at Universi...

    12. Harmonic Domain Modelling of Transformer Core Nonlinearities Using the DIgSILENT PowerFactory Software

      OpenAIRE

      Bak, Claus Leth; Bak-Jensen, Birgitte; Wiechowski, Wojciech

      2008-01-01

      This paper demonstrates the results of implementation and verification of an already existing algorithm that allows for calculating saturation characteristics of singlephase power transformers. The algorithm was described for the first time in 1993. Now this algorithm has been implemented using the DIgSILENT Programming Language (DPL) as an external script in the harmonic domain calculations of a power system analysis tool PowerFactory [10]. The algorithm is verified by harmonic measurements ...

    13. Dynamic wind turbine models in power system simulation tool DIgSILENT

      OpenAIRE

      Hansen, A.D.; Jauch, C.; Sørensen, Poul Ejnar; Iov, F.; Blaabjerg, F.

      2004-01-01

      The present report describes the dynamic wind turbine models implemented in the power system simulation tool DIgSILENT (Version 12.0). The developed models are a part of the results of a national research project, whose overall objective is to create amodel database in different simulation tools. This model database should be able to support the analysis of the interaction between the mechanical structure of the wind turbine and the electrical grid during different operational modes. The repo...

    14. Cumulus-specific genes are transcriptionally silent following somatic cell nuclear transfer in a mouse model*

      OpenAIRE

      Tong, Guo-qing; Heng, Boon-chin; Ng, Soon-chye

      2007-01-01

      This study investigated whether four cumulus-specific genes: follicular stimulating hormone receptor (FSHr), hyaluronan synthase 2 (Has2), prostaglandin synthase 2 (Ptgs2) and steroidogenic acute regulator protein (Star), were correctly reprogrammed to be transcriptionally silent following somatic cell nuclear transfer (SCNT) in a murine model. Cumulus cells of C57×CBA F1 female mouse were injected into enucleated oocytes, followed by activation in 10 µmol/L strontium chloride for 5 h and sub...

    15. Direct speech quotations promote low relative-clause attachment in silent reading of English.

      Science.gov (United States)

      Yao, Bo; Scheepers, Christoph

      2018-07-01

      The implicit prosody hypothesis (Fodor, 1998, 2002) proposes that silent reading coincides with a default, implicit form of prosody to facilitate sentence processing. Recent research demonstrated that a more vivid form of implicit prosody is mentally simulated during silent reading of direct speech quotations (e.g., Mary said, "This dress is beautiful"), with neural and behavioural consequences (e.g., Yao, Belin, & Scheepers, 2011; Yao & Scheepers, 2011). Here, we explored the relation between 'default' and 'simulated' implicit prosody in the context of relative-clause (RC) attachment in English. Apart from confirming a general low RC-attachment preference in both production (Experiment 1) and comprehension (Experiments 2 and 3), we found that during written sentence completion (Experiment 1) or when reading silently (Experiment 2), the low RC-attachment preference was reliably enhanced when the critical sentences were embedded in direct speech quotations as compared to indirect speech or narrative sentences. However, when reading aloud (Experiment 3), direct speech did not enhance the general low RC-attachment preference. The results from Experiments 1 and 2 suggest a quantitative boost to implicit prosody (via auditory perceptual simulation) during silent production/comprehension of direct speech. By contrast, when reading aloud (Experiment 3), prosody becomes equally salient across conditions due to its explicit nature; indirect speech and narrative sentences thus become as susceptible to prosody-induced syntactic biases as direct speech. The present findings suggest a shared cognitive basis between default implicit prosody and simulated implicit prosody, providing a new platform for studying the effects of implicit prosody on sentence processing. Copyright © 2018 Elsevier B.V. All rights reserved.

    16. Investigando con personas con dificultades de aprendizaje

      Directory of Open Access Journals (Sweden)

      Borja González Luna

      2013-12-01

      Full Text Available El artículo muestra los orígenes de lo que Walmsley (2008 denomina «investigación inclusiva». Para comprender qué se entiende por investigación inclusiva tenemos que remontarnos a los debates epistemológicos sobre las metodologías cuantitativas y cualitativas, acontecidos en la década de los 90, en torno a la revista Disability & Society. A partir de una síntesis de dichos debates, focalizados en el ámbito de la «discapacidad intelectual y del desarrollo», se exponen dos estrategias de colaboración con dicha población: a una aproximación etnográfica (de trabajo grupal, y b una aproximación biográfica (de trabajo individual. A continuación se esboza un posible diseño de trabajo de campo que intenta superar el paradigma cualitativo «clásico» con el objetivo de incluir a dicho colectivo más allá del rol de «sujetos de la investigación». Para finalizar se recoge el debate sobre la accesibilidad de los resultados de la investigación a los participantes en dichas investigaciones, y con ello la necesaria innovación en el ámbito de las «devoluciones» de los resultados, cuando se trata de incluir a personas que presentan limitaciones para la comprensión del lenguaje abstracto oral y/o escrito.

    17. Risk factors associated with the occurrence of silent pulmonary embolism in patients with deep venous thrombosis of the lower limb.

      Science.gov (United States)

      Li, Fenghe; Wang, Xuehu; Huang, Wen; Ren, Wei; Cheng, Jun; Zhang, Mao; Zhao, Yu

      2014-08-01

      The aim of our study is to investigate the prevalence of silent pulmonary embolism in patients with deep venous thrombosis in the lower limbs and to evaluate the associated risk factors. A total of 322 patients with acute deep venous thrombosis confirmed by CT venography or Doppler ultrasonography were studied. The diagnosis of silent pulmonary embolism was established by computed tomography pulmonary arteriography (CTPA). The association between covariates and the prevalence of silent pulmonary embolism in patients with deep venous thrombosis in lower limbs were assessed using chi-square test and multivariable regression. The incidence of silent pulmonary embolism was 33.5% (108 in 322 patients) in all patients with deep venous thrombosis in lower limbs. Chi-square test showed male gender, the right lower limb, proximal location of the thrombus, unprovoked venous thrombosis and coexisting heart diseases were related to a higher incidence of silent pulmonary embolism in patients with deep venous thrombosis in lower limbs. The multivariate regression analysis confirmed that the risk factors associated with silent pulmonary embolism in deep venous thrombosis patients included the right side and proximal location of the thrombus (odds ratio: 2.023, 95% CI: 1.215-3.368; odds ratio: 3.610, 95% CI: 1.772-7.354), unprovoked venous thrombosis (odds ratio: 2.037, 95% CI: 1.188-3.493), coexisting heart diseases (odds ratio: 4.507, 95% CI: 2.667-7.618). Silent pulmonary embolism occurred frequently in patients with deep venous thrombosis in lower limbs. The right side, the proximal location of the thrombus, unprovoked venous thrombosis and coexisting heart diseases increased the risk for the occurrence of silent pulmonary embolism. © The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

    18. Gated single photon emission computer tomography for the detection of silent myocardial ischemia

      International Nuclear Information System (INIS)

      Pena Q, Yamile; Coca P, Marco Antonio; Batista C, Juan Felipe; Fernandez-Britto, Jose; Quesada P, Rodobaldo; Pena C; Andria

      2009-01-01

      Background: Asymptomatic patients with severe coronary atherosclerosis may have a normal resting electrocardiogram and stress test. Aim: To assess the yield of Gated Single Photon Emission Computer Tomography (SPECT) for the screening of silent myocardial ischemia in type 2 diabetic patients. Material and methods: Electrocardiogram, stress test and gated-SPECT were performed on 102 type 2 diabetic patients aged 60 ± 8 years without cardiovascular symptoms. All subjects were also subjected to a coronary angiography, whose results were used as gold standard. Results: Gated-SPECT showed myocardial ischemia on 26.5% of studied patients. The sensibility, specificity, accuracy, positive predictive value and negative predictive value were 92.3%, 96%, 95%, 88.8%, 97.3%, respectively. In four and six patients ischemia was detected on resting electrocardiogram and stress test, respectively. Eighty percent of patients with doubtful resting electrocardiogram results and 70% with a doubtful stress test had a silent myocardial ischemia detected by gated-SPECT. There was a good agreement between the results of gated-SPECT and coronary angiography (k =0.873). Conclusions: Gated-SPECT was an useful tool for the screening of silent myocardial ischemia

    19. The prevalence and the clinical characteristics of silent myocardial ischemia detected by stress thallium scintigraphy

      International Nuclear Information System (INIS)

      Matsuo, Hitoshi; Watanabe, Sachiro; Nishida, Yoshio

      1992-01-01

      The prevalence of silent myocardial ischemia was retrospectively assessed in a group of 100 consecutive patients with angiographically proved coronary artery disease, and diagnostic ECG, by symptom-limited exercise thallium-201 scintigraphy. Twenty-four patients had no evidence of ischemia despite adequate exercise level. So among 76 patients with exercise induced ischemia, only 33 patients (43%) stopped exercise due to anginal pain (symptomatic ischemia: Group 3). And 43 patients with asymptomatic ischemia composed of 23 patients (30%) with ECG change (Group 2B) and 20 patients (26%) without ECG change (Group 2A). Patients background including the history of old myocardial infarction and diabetes mellitus, were similar among Group 2A, 2B, and Group 3. Our Major observation was that the extent and severity of quantified SPECT perfusion defects was nearly identified between 3 groups. Thus in this study group, there was a rather high prevalence rate of silent ischemia (57%) by exercise thallium-201 criteria. Patients with silent ischemia, associated with positive and negative exercise ECG findings, and those with exercise angina had similar background and comparable amount of jeopardized myocardium. (author)

    20. Detecting Silent Data Corruption for Extreme-Scale Applications through Data Mining

      Energy Technology Data Exchange (ETDEWEB)

      Bautista-Gomez, Leonardo [Argonne National Lab. (ANL), Argonne, IL (United States); Cappello, Franck [Argonne National Lab. (ANL), Argonne, IL (United States)

      2014-01-16

      Supercomputers allow scientists to study natural phenomena by means of computer simulations. Next-generation machines are expected to have more components and, at the same time, consume several times less energy per operation. These trends are pushing supercomputer construction to the limits of miniaturization and energy-saving strategies. Consequently, the number of soft errors is expected to increase dramatically in the coming years. While mechanisms are in place to correct or at least detect some soft errors, a significant percentage of those errors pass unnoticed by the hardware. Such silent errors are extremely damaging because they can make applications silently produce wrong results. In this work we propose a technique that leverages certain properties of high-performance computing applications in order to detect silent errors at the application level. Our technique detects corruption solely based on the behavior of the application datasets and is completely application-agnostic. We propose multiple corruption detectors, and we couple them to work together in a fashion transparent to the user. We demonstrate that this strategy can detect the majority of the corruptions, while incurring negligible overhead. We show that with the help of these detectors, applications can have up to 80% of coverage against data corruption.

    1. Harmony hurts: participation and silent conflict at an Indonesian fish pond.

      Science.gov (United States)

      Tam, Chui-Ling

      2006-07-01

      Participatory environmental and resource management is premised on open communication to reach consensus. However, deliberate and open communication cannot adequately address silent conflict. This begs two questions. First, how is the existence of covert communication and silent conflict to be recognized and addressed? Second, how are the wider social relations and traditions that encompass communication and conflict to be described and explained? These questions revolve around communicative power. Communication of environmental knowledge is deeply embedded in social power structures, with direct implications for participatory resource planning and implementation. Ethnographic research conducted at a failed community-managed fish farming project in Southeast Sulawesi, Indonesia shows that a culture of harmony and respect for authority can silence environmental conflict in the hierarchical "community." Three propositions are offered. First, communication amnesia and exclusion jeopardize participation. Second, cultures of harmony and silent conflict shape planning processes and outcomes. Third, the weak use manipulation and communication strategy to acquire a "voice" while preserving harmony. These propositions address five unresolved issues in participatory resource management: analysis of groups, contextuality, social relationships, nonparticipants, and informal communication. Power, tradition, and social networks affect the valuing of knowledge relative to the power of different individuals and institutions to communicate priorities, values, and needs. These factors are critical to the inclusion of both participants and nonparticipants.

    2. Silent and a audible stereotypes: The constitution of "ethnic character" in Serbian epic poetry

      Directory of Open Access Journals (Sweden)

      Đerić Gordana

      2005-01-01

      Full Text Available The article deals with the explanatory relevance of the concept of stereotype in one of its original meanings - as a "mental image". This meaning of the term is the starting point for further differentiations, such as: between linguistic and behavioral stereotypes (in the sense of nonverbal, expected responses; universal and particular stereotypes; self representative and introspective stereotypes; permanent and contemporary stereotypes; and finally, what is most important for our purposes, the difference between silent and audible stereotypes. These distinctions, along with the functions of stereotype, are discussed in the first part of the paper. In the second part, the relations of silent and audible stereotypes are tested against the introduction of "innovative vocabularies" in popular lore. In other words, the explanatory power of this differentiation is checked through an analysis of unconventional motives in Serbian epic poems. The goal of the argument is to clarify the procedure of self creation of masculinity as a relevant feature of the "national character" through "tactic games" of silent and audible stereotypes. The examination of these "poetic strategies" serves a twofold purpose: to illustrate the process of constructing particular features of the "ethno type", on one hand, and to check hypotheses and models which are taken as frameworks in analyzing stereotypes, on the other.

    3. Estimation of cortical silent period following transcranial magnetic stimulation using a computerised cumulative sum method.

      Science.gov (United States)

      King, Nicolas K K; Kuppuswamy, Annapoorna; Strutton, Paul H; Davey, Nick J

      2006-01-15

      The cortical silent period (CSP) following transcranial magnetic stimulation (TMS) of the motor cortex can be used to measure intra-cortical inhibition and changes in a number of important pathologies affecting the central nervous system. The main drawback of this technique has been the difficulty in accurately identifying the onset and offset of the cortical silent period leading to inter-observer variability. We developed an automated method based on the cumulative sum (Cusum) technique to improve the determination of the duration and area of the cortical silent period. This was compared with experienced raters and two other automated methods. We showed that the automated Cusum method reliably correlated with the experienced raters for both duration and area of CSP. Compared with the automated methods, the Cusum also showed the strongest correlation with the experienced raters. Our results show the Cusum method to be a simple, graphical and powerful method of detecting low-intensity CSP that can be easily automated using standard software.

    4. Silent reading of direct versus indirect speech activates voice-selective areas in the auditory cortex.

      Science.gov (United States)

      Yao, Bo; Belin, Pascal; Scheepers, Christoph

      2011-10-01

      In human communication, direct speech (e.g., Mary said: "I'm hungry") is perceived to be more vivid than indirect speech (e.g., Mary said [that] she was hungry). However, for silent reading, the representational consequences of this distinction are still unclear. Although many of us share the intuition of an "inner voice," particularly during silent reading of direct speech statements in text, there has been little direct empirical confirmation of this experience so far. Combining fMRI with eye tracking in human volunteers, we show that silent reading of direct versus indirect speech engenders differential brain activation in voice-selective areas of the auditory cortex. This suggests that readers are indeed more likely to engage in perceptual simulations (or spontaneous imagery) of the reported speaker's voice when reading direct speech as opposed to meaning-equivalent indirect speech statements as part of a more vivid representation of the former. Our results may be interpreted in line with embodied cognition and form a starting point for more sophisticated interdisciplinary research on the nature of auditory mental simulation during reading.

    5. Detection of silent cells, synchronization and modulatory activity in developing cellular networks.

      Science.gov (United States)

      Hjorth, Johannes J J; Dawitz, Julia; Kroon, Tim; Pires, Johny; Dassen, Valerie J; Berkhout, Janna A; Emperador Melero, Javier; Nadadhur, Aish G; Alevra, Mihai; Toonen, Ruud F; Heine, Vivi M; Mansvelder, Huibert D; Meredith, Rhiannon M

      2016-04-01

      Developing networks in the immature nervous system and in cellular cultures are characterized by waves of synchronous activity in restricted clusters of cells. Synchronized activity in immature networks is proposed to regulate many different developmental processes, from neuron growth and cell migration, to the refinement of synapses, topographic maps, and the mature composition of ion channels. These emergent activity patterns are not present in all cells simultaneously within the network and more immature "silent" cells, potentially correlated with the presence of silent synapses, are prominent in different networks during early developmental periods. Many current network analyses for detection of synchronous cellular activity utilize activity-based pixel correlations to identify cellular-based regions of interest (ROIs) and coincident cell activity. However, using activity-based correlations, these methods first underestimate or ignore the inactive silent cells within the developing network and second, are difficult to apply within cell-dense regions commonly found in developing brain networks. In addition, previous methods may ignore ROIs within a network that shows transient activity patterns comprising both inactive and active periods. We developed analysis software to semi-automatically detect cells within developing neuronal networks that were imaged using calcium-sensitive reporter dyes. Using an iterative threshold, modulation of activity was tracked within individual cells across the network. The distribution pattern of both inactive and active, including synchronous cells, could be determined based on distance measures to neighboring cells and according to different anatomical layers. © 2015 Wiley Periodicals, Inc.

    6. Silent cerebral infarction, income, and grade retention among students with sickle cell anemia

      Science.gov (United States)

      King, Allison A.; Rodeghier, Mark J.; Panepinto, Julie Ann; Strouse, John J.; Casella, James F.; Quinn, Charles T.; Dowling, Michael M.; Sarnaik, Sharada A.; Thompson, Alexis A.; Woods, Gerald M.; Minniti, Caterina P.; Redding-Lallinger, Rupa C.; Kirby-Allen, Melanie; Kirkham, Fenella J.; McKinstry, Robert; Noetzel, Michael J.; White, Desiree A.; Kwiatkowski, Janet K.; Howard, Thomas H.; Kalinyak, Karen A.; Inusa, Baba; Rhodes, Melissa M.; Heiny, Mark E.; Fuh, Ben; Fixler, Jason M.; Gordon, Mae O.; DeBaun, Michael R.

      2014-01-01

      Children with sickle cell anemia have a higher-than-expected prevalence of poor educational attainment. We test two key hypotheses about educational attainment among students with sickle cell anemia, as measured by grade retention and use of special education services: (1) lower household per capita income is associated with lower educational attainment; (2) the presence of a silent cerebral infarct is associated with lower educational attainment. We conducted a multicenter, cross-sectional study of cases from 22 U.S. sites included in the Silent Infarct Transfusion Trial. During screening, parents completed a questionnaire that included sociodemographic information and details of their child’s academic status. Of 835 students, 670 were evaluable; 536 had data on all covariates and were used for analysis. The students’ mean age was 9.4 years (range: 5–15) with 52.2% male; 17.5% of students were retained one grade level and 18.3% received special education services. A multiple variable logistic regression model identified that lower household per capita income (odds ratio [OR] of quartile 1 = 6.36, OR of quartile 2 = 4.7, OR of quartile 3 = 3.87; P = 0.001 for linear trend), age (OR = 1.3; P sickle cell anemia, household per capita income is associated with grade retention, whereas the presence of a silent cerebral infarct is not. Future educational interventions will need to address both the medical and socioeconomic issues that affect students with sickle cell anemia. PMID:25042018

    7. Pérdida del precondicionamiento isquémico: un fenómeno relacionado con el envejecimiento

      Directory of Open Access Journals (Sweden)

      Jorge A. Belardi

      2007-01-01

      Full Text Available IntroducciónLa edad es un predictor independiente de riesgo en pacientes con enfermedad coronaria.Esto podría explicarse por la falta de adaptación a la isquemia miocárdica aguda. Elprecondicionamiento es un mecanismo por el cual episodios repetitivos de isquemia inducenen el miocardio una tolerancia mayor a episodios subsiguientes.ObjetivoEvaluar el desarrollo de precondicionamiento isquémico en pacientes añosos.Material y métodosSe incluyeron 65 pacientes sometidos a angioplastia coronaria electiva (< 70 años [n = 47] y≥ 70 años [n = 18]. Se evaluó el desarrollo de precondicionamiento durante tres períodos deoclusión coronaria. Por ECG intracoronario se midió la elevación del ST al final de cada dilatacióny se registró el porcentaje de resolución del ST a la tercera dilatación respecto del máximovalor registrado. Los datos se presentan como mediana e intervalo intercuartil 25/75%.ResultadosNo hubo diferencias significativas en las características clínicas basales. El máximo ST registrado,el ST a la tercera dilatación y el porcentaje de resolución del ST fueron 14 (9/24mm, 8 (4/14 mm y 23,8% (0/55,5 para los pacientes jóvenes y 9,5 (5/18 mm (p = ns, 6,5 (4/16 mm (p = ns y 5,5% (0/20 (p = 0,04 para los añosos. Al estratificar por grupos etarios,la proporción de pacientes que alcanzaron una resolución del ST ≥ 50% mostró una distribuciónlineal por chi cuadrado de tendencia (p = 0,025.ConclusionesNuestro estudio sugiere que el precondicionamiento isquémico se encontraría disminuidoen pacientes añosos. La funcionalidad de este mecanismo menguaría en forma progresivacon el envejecimiento.

    8. Dexmedetomidine and S(+-ketamine in ischemia and reperfusion injury in the rat kidney Dexmedetomidina e S(+-cetamina em lesão de isquemia e reperfusão no rim de rato

      Directory of Open Access Journals (Sweden)

      Fabio Geraldo Curtis

      2011-06-01

      Full Text Available PURPOSE: To investigate blood creatinine and renal histology in rats anesthetized with S(+-ketamine (keta or dexmedetomidine (dex and submitted to kidney ischemia/reperfusion injury (IRI. METHODS: Under intraperitoneal (ip S(+-ketamine, 20 male Wistar rats were divided into two groups (n=10: maintenance with iv S(+-ketamine or dex (keta and dex groups, and submitted to right (R nephrectomy and left (L renal artery clamping for 45 min. Blood creatinine was measured before ischemia (T1 and 48h after reperfusion (T2, when L nephrectomy was performed. Histological analysis was performed in all kidneys. RESULTS: Blood creatinine was significantly higher at T2 in both groups, but dex group results were lower than those of keta group. Histological changes: between groups, R kidneys did not differ; there were significant high scores for vascular dilation: keta L kidneys; for vascular congestion, tubular dilation, and necrosis: L kidneys from both groups; for tubular degeneration: keta R kidneys. CONCLUSION: S(+-ketamine plus IRI were aggressive to rat kidneys, according to histological changes, and dexmedetomidine may have not totally protected the kidneys from these injuries, despite the better results of blood creatinine.OBJETIVO: Investigar a creatinina sanguínea e histologia renal em ratos anestesiados com S(+-cetamina (ceta ou dexmedetomidina (dex e submetidos à lesão de isquemia/reperfusão renal (IR. MÉTODOS: Sob S(+-cetamina intraperitoneal (ip, 20 ratos Wistar machos foram distribuídos em dois grupos (n=10: manutenção com S(+-cetamina ou dexmedetomidina, iv, (grupos ceta e dex, e submetidos à nefrectomia direita (D e clampeamento da artéria renal esquerda (E por 45 min. A creatinina sanguínea foi dosada antes da isquemia (T1 e 48h após a reperfusão (T2, quando foi realizada nefrectomia E. Houve análise histológica de todos os rins. RESULTADOS: A creatinina foi significativamente maior em T2 em ambos os grupos, porém menor com a

    9. Estrategias de reperfusión usadas en pacientes con síndrome coronario agudo con elevación persistente del segmento ST en un hospital general: Reperfusion strategies in patients with acute coronary syndrome and persistent ST-segment elevation in a general hospital

      Directory of Open Access Journals (Sweden)

      Luis Borda-Velásquez

      2015-01-01

      Full Text Available Objetivos: Conocer las estrategias de reperfusión en pacientes con síndrome coronario agudo ST elevado (SCASTE atendidos en el departamento de emergencia de un hospital general, y determinar el tiempo para realizar dichas estrategias a través de los tiempos puerta-aguja (P-A, puerta-balón (P-B, electrocardiograma (ECG y total de isquemia. Material y métodos: Estudio retrospectivo transversal en pacientes con diagnóstico de SCASTE en el Hospital Nacional Cayetano Heredia (HNCH desde el 1° de enero de 2011 al 31 de enero de 2013. Se registraron las características demográficas y clínicas, tiempos de reperfusión miocárdica, de síntomas, para toma de ECG. Los factores asociados fueron analizados por análisis bivariado. Resultados: Cuarenta y cinco pacientes fueron elegibles. La edad media fue 60,5 ± 10,98 años, 88,8% fueron varones. El tiempo medio de hospitalización fue 9,79 ± 10,36 días. Se encontró obesidad (IMC ≥ 30 en 61,3%; hipertensión en 40,9%: tabaquismo en 43,1%; y diabetes mellitus II (DM II en 25%. El tiempo medio P-A de 57 ± 54,1 minutos; en 28,1% se administró el agente trombolítico antes de los 30 minutos. Angioplastia fue realizada en un paciente con un tiempo P-B de 440 minutos. El tiempo total de isquemia (TTI medio fue 244 ± 143,9 minutos. Conclusiones: Las estrategias de reperfusión fueron usadas en 71,1% de pacientes, siendo trombólisis la más usada; sin embargo, el tiempo P-A se encontró fuera del rango óptimo

    10. Giochiamo con i robot

      Directory of Open Access Journals (Sweden)

      Andrea Bonarini

      2009-01-01

      Full Text Available "Giochiamo con i robot" e' un laboratorio interattivo per grandi e piccini realizzato per l'edizione 2007 del Festival della Scienza di Genova. Lungo un percorso che va dalla telerobotica alla robotica evolutiva, il laboratorio sviluppa il tema di dare intelligenza ai robot. Questo percorso, le cui tappe sono le varie installazioni, si conclude nella "bottega" dove e' possibile costruire e programmare i propri robot o smontare e modificare quelli esposti durante il percorso didattico. I visitatori sono coinvolti in attivita' ludiche grazie alle quali possonoentrare in contatto con alcune delle idee potenti della robotica,

    11. disegnare con ... Alberto Pratelli

      Directory of Open Access Journals (Sweden)

      Roberto Mingucci

      2017-12-01

      Full Text Available Con questa breve intervista ad Alberto Pratelli, (non a caso scelto per aprire questa nuova rubrica intendia-mo inaugurare un dialogo con personalità significati-ve del Disegno di Architettura, che consenta riflessioni dedicate alle sue varie dimensioni, oggi più che mai da approfondire. La suggestione a farlo, viene da un’idea di Pablo Rodri-guez Navarro ed abbiamo quindi pensato di avviarla proprio in questo numero, che Pablo ha accettato di curare su un tema a lui particolarmente caro.

    12. Efecto del hialuronato de zinc sobre las úlceras en pacientes con diabetes

      Directory of Open Access Journals (Sweden)

      Fernando Ramos Cuevas

      Full Text Available Contexto: La úlcera en el pie diabético es una de las principales complicaciones de la diabetes en extremidades bajas. Del 50 al 70% de las amputaciones en extremidades bajas se realizan a pacientes con diabetes. El hialuronato de zinc ha sido probado en el tratamiento de las úlceras diabéticas del pie con resultados prometedores. Objetivo general: Determinar el grado de eficacia del hialuronato de zinc en la curación de úlceras del pie diabético. Diseño: Ensayo terapéutico abierto al azar. Se les dio seguimiento a los pacientes durante un período de doce semanas de junio a diciembre de 2004. Ubicación: Centro de cuidado terciario. Clínica del Pie Diabético. Pacientes: Fueron seleccionados por muestreo consecutivo cincuenta pacientes con diabetes tipo 2 con úlcera en pie, de ambos sexos y con edades entre los 40 y los 80 años y sin una isquemia más baja de la extremidad. Veinticinco de ellos fueron asignados aleatoriamente al grupo del hialuronato de zinc y el resto al grupo de control (tratamiento convencional. La distribución por sexo de género fue similar en ambos grupos, once del femenino (44% y 14 del masculino (56%. La edad promedio en el grupo de la combinación del ácido hialurónico y zinc fue 56,76 ± 8,78 y en el convencional 60,12 ± 8,42, NS. ningún paciente del grupo de hialuronato de zinc abandonó o fue retirado durante el período del estudio. Un paciente del grupo de control falleció. Intervención: El hialuronato de zinc fue aplicado una vez al día en la superficie de la úlcera después de limpiarla con la solución fisiológica salina. Medida principal del resultado: La eficacia del hialuronato de zinc fue determinada por las semanas que se requirieron para conseguir el cierre completo de la úlcera con el tejido fino epitelial (tiempo curativo medio. Material y métodos: Ensayo clínico controlado. Pacientes con úlceras propias del pie diabético. 1 de julio al 30 de septiembre de 2004, 25 pacientes

    13. Conversando con Oriol Bohigas

      OpenAIRE

      Redondo Domínguez, Ernesto; Moya Sala, Joaquim

      2015-01-01

      [EN] Interview with Oriol Bohigas [ES] Entrevista con Oriol Bohigas Redondo Domínguez, E.; Moya Sala, J. (2015). Conversando con… Oriol Bohigas. EGA. Revista de Expresión Gráfica Arquitectónica. 20(26):22-35. doi:10.4995/ega.2015.4061 22 35 20 26

    14. DR Con o:

      African Journals Online (AJOL)

      which could fall under the Ugandan influence. The con-. flict in the ..... The Congolese people and international community within SADC, the AU ..... ments and make peace among themselves. However, one ... friends overnight.There is a great ...

    15. fertilizada con diferentes abonos

      Directory of Open Access Journals (Sweden)

      Jorge Alberto Elizondo-Salazar

      2007-01-01

      Full Text Available Producción y calidad de la biomasa de morera (Morus alba fertilizada con diferentes abonos. Se llevó a cabo un experimento en la Estación Experimental “Alfredo Volio Mata” de la Universidad de Costa Rica con el fi n de evaluar la aplicación de 150 kg de N/ha/año proveniente de dos abonos orgánicos: lombriabono y compostaje; y de un fertilizante químico, sobre la producción y calidad de la biomasa de morera. El periodo experimental comprendió un ciclo de 12 meses, iniciando en julio del 2003 y fi nalizando en julio del 2004. Se utilizó una plantación de morera de 12 años de establecida con una densidad de siembra de 27.777 plantas/ ha. Se empleó un diseño de bloques completos al azar con cuatro tratamientos: dos abonos orgánicos, nitrato de amonio (33,5% N y un control. Las plantas se podaron a 0,6 m sobre el nivel del suelo al inicio del ensayo. Durante el periodo experimental, las plantas fueron podadas consecutivamente cada 90 días. Las hojas y los tallos fueron separados y analizados para determinar el contenido de materia seca y proteína cruda. La producción de materia seca fue 23% superior y el contenido de proteína cruda fue signifi cativamente mayor con el nitrógeno químico, mientras que el contenido de materia seca fue menor. No se encontraron diferencias signifi cativas entre el tratamiento control y los tratamientos orgánicos.

    16. Rtt107/Esc4 binds silent chromatin and DNA repair proteins using different BRCT motifs

      Directory of Open Access Journals (Sweden)

      Jockusch Rebecca A

      2006-11-01

      Full Text Available Abstract Background By screening a plasmid library for proteins that could cause silencing when targeted to the HMR locus in Saccharomyces cerevisiae, we previously reported the identification of Rtt107/Esc4 based on its ability to establish silent chromatin. In this study we aimed to determine the mechanism of Rtt107/Esc4 targeted silencing and also learn more about its biological functions. Results Targeted silencing by Rtt107/Esc4 was dependent on the SIR genes, which encode obligatory structural and enzymatic components of yeast silent chromatin. Based on its sequence, Rtt107/Esc4 was predicted to contain six BRCT motifs. This motif, originally identified in the human breast tumor suppressor gene BRCA1, is a protein interaction domain. The targeted silencing activity of Rtt107/Esc4 resided within the C-terminal two BRCT motifs, and this region of the protein bound to Sir3 in two-hybrid tests. Deletion of RTT107/ESC4 caused sensitivity to the DNA damaging agent MMS as well as to hydroxyurea. A two-hybrid screen showed that the N-terminal BRCT motifs of Rtt107/Esc4 bound to Slx4, a protein previously shown to be involved in DNA repair and required for viability in a strain lacking the DNA helicase Sgs1. Like SLX genes, RTT107ESC4 interacted genetically with SGS1; esc4Δ sgs1Δ mutants were viable, but exhibited a slow-growth phenotype and also a synergistic DNA repair defect. Conclusion Rtt107/Esc4 binds to the silencing protein Sir3 and the DNA repair protein Slx4 via different BRCT motifs, thus providing a bridge linking silent chromatin to DNA repair enzymes.

    17. The association between saliva control, silent saliva penetration, aspiration, and videofluoroscopic findings in Parkinson's disease patients

      Science.gov (United States)

      Rajaei, Ali; Ashtari, Fereshteh; Azargoon, Seyed Abolfazl; Chitsaz, Ahmad; Nilforoush, Mohammad Hussein; Taheri, Masoud; Sadeghi, Saba

      2015-01-01

      Background: Dysphagia is a common disorder among patients with Parkinson's disease (PD). It occurs in up to 80% of all (PD) patients during the early stages of the disease and up to 95% in the advanced stages; but professionals may not hear from the patients about dysphagia symptoms until these symptoms reach an advanced stage and lead to medical complications. Materials and Methods: Thirty-three PD patients (mean age 66.09 ± 9.4 years; 24 men, nine women) participated in this study at our Neurology Institute, between April 20, 2013, and October 26, 2013. They were asked two questions; one about saliva control and the other about silent saliva penetration and aspiration. Next, they underwent the videofluoroscopic swallowing study (VFSS). Results: The Pearson Correlation coefficient between the Penetration–Aspiration Scale (PAS) scores and question 1 scores was 0.48 (P < 0.05, =0.25), and there was a significant correlation between the PAS scores and question 2 scores, and also question 1 scores + question 2 scores (r = 0.589, P < 0.05, =0 and r = 0589, P < 0.05, =0). Conclusions: This study showed a significant correlation between the questions about saliva control, silent saliva penetration, and aspiration, and laryngeal penetration and aspiration during VFSS. Therefore, by using these two questions, the potential silent laryngeal penetration and aspiration during meals could be detected before it led to aspiration pneumonia. Taking the benefit of these questions, as a part of the swallowing assessment of PD patients, is recommended. PMID:26261810

    18. Reliability of the exercise ECG in detecting silent ischemia in patients with prior myocardial infarction

      International Nuclear Information System (INIS)

      Yamagishi, Takashi; Matsuda, Yasuo; Satoh, Akira

      1991-01-01

      To assess the reliability of the exercise ECG in detecting silent ischemia, ECG results were compared with those of stress-redistribution thallium-201 single-photon emission computed tomography (SPECT) in 116 patients with prior myocardial infarction and in 20 normal subjects used as a control. The left ventricle (LV) was divided into 20 segmental images, which were scored blindly on a 5-point scale. The redistribution score was defined as thallium defect score of exercise subtracted by that of redistribution image and was used as a measure of amount of ischemic but viable myocardium. The upper limit of normal redistribution score (=4.32) was defined as mean+2 standard deviations derived from 20 normal subjects. Of 116 patients, 47 had the redistribution score above the normal range. Twenty-five (53%) of the 47 patients showed positive ECG response. Fourteen (20%) of the 69 patients, who had the normal redistribution score, showed positive ECG response. Thus, the ECG response had a sensitivity of 53% and a specificity of 80% in detecting transient ischemia. Furthermore, the 116 patients were subdivided into 4 groups according to the presence or absence of chest pain and ECG change during exercise. Fourteen patients showed both chest pain and ECG change and all these patients had the redistribution score above the normal range. Twenty-five patients showed ECG change without chest pain and 11 (44%) of the 25 patients had the abnormal redistribution. Three (43%) of 7 patients who showed chest pain without ECG change had the abnormal redistribution score. Of 70 patients who had neither chest pain nor ECG change, 19 (27%) had the redistribution score above the normal range. Thus, limitations exist in detecting silent ischemia by ECG in patients with a prior myocardial infarction, because the ECG response to the exercise test may have a low degree of sensitivity and a high degree of false positive and false negative results in detecting silent ischemia. (author)

    19. Dynamic wind turbine models in power system simulation tool DIgSILENT

      Energy Technology Data Exchange (ETDEWEB)

      Hansen, A.C.; Jauch, C.; Soerensen, P.; Iov, F.; Blaabjerg, F.

      2003-12-01

      The present report describes the dynamic wind turbine models implemented in the power system simulation tool DIgSILENT (Version 12.0). The developed models are a part of the results of a national research project, whose overall objective is to create a model database in different simulation tools. This model database should be able to support the analysis of the interaction between the mechanical structure of the wind turbine and the electrical grid during different operational modes. The report provides a description of the wind turbines modelling, both at a component level and at a system level. The report contains both the description of DIgSILENT built-in models for the electrical components of a grid connected wind turbine (e.g. induction generators, power converters, transformers) and the models developed by the user, in the dynamic simulation language DSL of DIgSILENT, for the non-electrical components of the wind turbine (wind model, aerodynamic model, mechanical model). The initialisation issues on the wind turbine models into the power system simulation are also presented. However, the main attention in this report is drawn to the modelling at the system level of two wind turbine concepts: 1. Active stall wind turbine with induction generator 2. Variable speed, variable pitch wind turbine with doubly fed induction generator. These wind turbine concept models can be used and even extended for the study of different aspects, e.g. the assessment of power quality, control strategies, connection of the wind turbine at different types of grid and storage systems. For both these two concepts, control strategies are developed and implemented, their performance assessed and discussed by means of simulations. (au)

    20. Application of DIgSILENT POWERFACTORY software for modeling of industrial network relay protection system

      Directory of Open Access Journals (Sweden)

      Sučević Nikola

      2016-01-01

      Full Text Available This paper presents modeling of industrial network relay protection system using DIgSILENT PowerFactory software. The basis for the model of protection system is a model of a single substation in an industrial network. The paper presents the procedure for modeling of protective devices of 6 kV asynchronous motors, 6/0,4 kV/kV transformers as well as protection in the bus coupler and busbar protection. Protective relay system response for the simulated disturbances is shown in the paper.

    1. Static Aeroelastic Deformation Effects in Preliminary Wind-tunnel Tests of Silent Supersonic Technology Demonstrator

      OpenAIRE

      Makino, Yoshikazu; Ohira, Keisuke; Makimoto, Takuya; Mitomo, Toshiteru; 牧野, 好和; 大平, 啓介; 牧本, 卓也; 三友, 俊輝

      2011-01-01

      Effects of static aeroelastic deformation of a wind-tunnel test model on the aerodynamic characteristics are discussed in wind-tunnel tests in the preliminary design phase of the silent supersonic technology demonstrator (S3TD). The static aeroelastic deformation of the main wing is estimated for JAXA 2m x 2m transonic wind-tunnel and 1m x 1m supersonic wind-tunnel by a finite element method (FEM) structural analysis in which its structural model is tuned with the model deformation calibratio...

    2. "Luck's always to blame": silent wounds of a penetrating gunshot trauma sustained 20 years ago.

      Science.gov (United States)

      Tomos, Ioannis; Manali, Effrosyni D; Argentos, Stylianos; Raptakis, Thomas; Papiris, Spyros A

      2015-01-01

      Gunshot tracheal injuries represent life-threatening events and usually necessitate emergent surgical intervention. We report a case of an exceptional finding of a patient with retained ballistic fragments in the soft tissues of the thorax, proximal to the right subclavian artery and the trachea, carrying silently his wounds for two decades without any medical or surgical intervention. The bullet pellet on the upper part of the trachea seen accidentally in the chest computed tomography, was also found during bronchoscopy. In short "luck's always to blame".

    3. Osteoporosis - "a silent killer". A review of the current literature from clinician and physiotherapist perspective

      Directory of Open Access Journals (Sweden)

      Janusz Kocjan

      2015-07-01

      SUMMARY             Osteoporosis is a disease characterized by low bone mass and deterioration of bone structure that causes bone fragility and increases the risk of fracture. Individuals with osteoporosis are at high risk of suffering one or more fractures, which are often physically debilitating and can potentially lead to a downward spiral in physical and mental health. Article attempts to discuss this issue from the clinical and rehabilitation perspective. Following contents were included: diagnosis, types of osteoporosis, epidemiology, burden of osteoporosis, types of fractures, treatment and rehabilitation of osteoporosis.   Key words: osteoporosis, porous bone, low bone mass, silent disease.

    4. Incidence of postangiographic silent brain infarction detected by diffusion-weighted MR imaging

      International Nuclear Information System (INIS)

      Mori, Harushi; Hayashi, Naoto; Aoki, Shigeki

      2002-01-01

      We surveyed to assess for the incidence of clinically silent brain infarction after cerebral catheter angiography. Diffusion-weighted images were performed shortly after 33 cerebral catheter angiographies. We found totally 11 abnormally high intensity spots in 5 of 33 patients on diffusion-weighted images and, therefore, the incidence was calculated as 15.2%. This incidence is higher than has been estimated based on the incidence of neurological deficits (about 0.5%) after cerebral angiography. Diffusion-weighted MR imaging is suitable to monitor the safety of angiographic procedures and material. (author)

    5. Reflections on clinical expertise and silent know-how in voice therapy

      DEFF Research Database (Denmark)

      Iwarsson, Jenny

      2014-01-01

      The concept of ‘clinical expertise’ is described as a part of evidence-based practice (EBP) together with ‘external scientific evidence’ and ‘patient values and perspectives’. However, clinical expertise in the management of voice disorders has not been described or discussed in much detail....... The expertise seems to consist partly of silent know-how that, from the outside, may seem improperly related to the personality of the speech-language pathologist or exclusively dependent on the number of years in the field. In this paper, it is suggested that clinical expertise in voice therapy consists...

    6. Application of DIgSILENT POWERFACTORY software for modeling of industrial network relay protection system

      OpenAIRE

      Sučević Nikola; Milošević Dejan

      2016-01-01

      This paper presents modeling of industrial network relay protection system using DIgSILENT PowerFactory software. The basis for the model of protection system is a model of a single substation in an industrial network. The paper presents the procedure for modeling of protective devices of 6 kV asynchronous motors, 6/0,4 kV/kV transformers as well as protection in the bus coupler and busbar protection. Protective relay system response for the simulated disturbances is shown in the paper.

    7. Accuracy of Ultrasonography and Rectal Palpation in the Diagnosis of Silent Heat in Cows Compared to Plasma Progesterone Concentration

      International Nuclear Information System (INIS)

      Zdunczyk, S.; Janowski, T.; Ras, A.; Baranski, W.

      2009-01-01

      The study was carried out on five dairy herds in the North-East Poland. The cows, which showed no visible oestrus signs until day 60 postpartum, were examined by ultrasonography and rectal palpation twice, at a 10-d interval. A real-time, B-mode scanner with a 5 MHz probe was used. The plasma progesterone concentration was determined using RIA. A high progesterone level on the first examination, but low on the second, or low on the first and high on the second examination were interpreted as a silent heat. Based on the progesterone values, silent heat was diagnosed in 145 anoestrous cows, whereas ultrasonographically, 106 cows were found to have silent heat. The accuracy of the ultrasonography and rectal palpation in the diagnosis of silent heat in cows was 89.0 % and 69.7 %, respectively (P ≤ 0.05). For the diagnosis of the corpus luteum, the sensitivity and specificity of the ultrasonography was 94.7 % and 84.0 %, and for rectal palpation 86.2 % and 70.3 %, respectively (P ≤ 0.05). Our results showed that ultrasonography is a useful tool in the diagnosis of silent heat in cows. (authors)

    8. Silent Ischemia

      Science.gov (United States)

      ... Rounds Seminar Series & Daily Conferences Fellowships and Residencies School of Perfusion Technology Education Resources Library & Learning Resource Center CME Resources THI Journal THI Cardiac Society Register for the Cardiac Society ...

    9. Silent Struggles

      DEFF Research Database (Denmark)

      Girschik, Verena; Boxenbaum, Eva

      when overt contestation is not a viable option – for example when they must dampen conflict to foster collaboration. This paper presents a case study of a Danish pharmaceutical company that overcame framing contexts, gained local stakeholders’ support and became the orchestrator of collaborative...... arrangements aimed at improving diabetes care in Indonesia. Inductively following the framing process in real-time, the paper presents a model that explicates three moves through which frame alignment was constructed: interactively reconstructing the field, manufacturing a common understanding of actions...

    10. Silent thyroiditis

      Science.gov (United States)

      ... to the touch Rapid heart rate Shaking hands (tremor) Tests that may be done include: Radioactive iodine uptake Thyroid hormones T3 and T4 TSH Treatment Treatment is based on symptoms. Medicines called beta-blockers may be used to relieve rapid heart rate ...

    11. Is subdiaphragmatic aortic cross-clamping a suitable model for spinal cord ischemia/reperfusion injury study in rats? O pinçamento sub-diagragmático da aorta é um modelo adequado para o estudo da lesão medular de isquemia/reperfusão em ratos?

      Directory of Open Access Journals (Sweden)

      Sonia Elizabeth Lopez Carrillo

      2006-08-01

      Full Text Available PURPOSE: To evaluate the efficacy of subdiaphragmatic aortic cross-clamping in an experimental model of ischemia/reperfusion injury of the spinal cord in albino rats. METHODS: Thirty-six male Wistar rats were randomized in two groups (n=18: G-1 (Sham and G-2 (Ischemia/Reperfusion, I/R. G-2 rats were submitted to 30 min subdiafragmatic aortic cross-clamping. G-1 rats served as controls and were submitted to surgical trauma (laparotomy without ischemia. Samples (spinal cord and arterial blood were collected at the end of ischemic period and 10 (T-10 and 20 (T-20 min later in G-2 rats. Sham rats (G-1 samples were collected at the same time-points. Blood and tissue metabolites concentrations of pyruvate, lactate, glucose and medullary adenosine triphosphate (ATP were assayed. RESULTS: Blood and tissue concentrations of pyruvate and glucose as well as lactate and medullary ATP were not different when comparing G1 to G2. Lactacemia was significantly elevated in G-2 compared with G-1 rats during reperfusion (T-10. CONCLUSION: Subdiaphragmatic aortic cord cross-clamping is not a suitable rat model for spinal cord ischemia/reperfusion injury study as it does not ensure changes in in vivo tissue metabolites concentrations similar to those found in tissues subjected to ischemia/reperfusion.OBJETIVO: Avaliar a eficácia do pinçamento da aorta subdiafragmática no modelo experimental de isquemia/reperfusão da medula espinhal em ratos. MÉTODOS: Trinta e seis ratos Wistar, machos, foram aleatoriamente distribuídos em 2 grupos (n=18 e submetidos ao pinçamento subdiafragmático da aorta, durante 30 minutos (Grupo-2 -Isquemia/Reperfusão. Os ratos do Grupo-1 (G-1 - Sham foram utilizados como controles e submetidos a laparotomia sem pinçamento arterial. As amostras (medula e sangue arterial foram coletadas ao término do período de isquemia (T-0 e 10 (T-10 e 20 (T-20 minutos mais tarde e nos mesmos intervalos, no grupo G-1. As concentrações teciduais e

    12. pacientes con falla cardiaca

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      Diana Marcela Achury Saldaña

      2007-01-01

      Full Text Available Objetivo: determinar la adherencia al tratamiento de pacientes con falla cardiaca hospitalizados, al aplicar un plan educativo quefomenta el autocuidado.Método: estudio cuasiexperimental (entrevistas enfermera-paciente realizado entre diciembre de 2004 y mayo de 2006, con unamuestra de 50 pacientes seleccionados por conveniencia. Se diseñó un instrumento para evaluar los comportamientos de los pacientes,con base en algunos resultados de la adherencia y sus respectivos indicadores de la taxonomía NOC (Nursing out comes classification. Laadherencia al tratamiento fue medida en dos momentos: el primero durante la hospitalización, seguido de la aplicación del plan educativoantes del alta, que proporcionaba información en el manejo de su enfermedad desde una dimensión física, psicológica y social quepromueve el autocuidado; y el segundo un mes después del alta en su domicilio.Resultados: diferencias estadísticamente significativas (P=0,0001 que demuestran cómo mediante la capacitación al paciente enel manejo de su tratamiento farmacológico y no farmacológico, el establecimiento de una sana relación entre el profesional de enfermeríay el paciente, y la participación de la familia, se logra una total adherencia al tratamiento.Conclusiones: para lograr una adherencia total del paciente con falla cardiaca al tratamiento es necesario un proceso educativo y unseguimiento continuo y personalizado que motive permanentemente al paciente y se le reconozca el papel protagónico en su cuidado y manejo de la enfermedad.

    13. The Tzu Chi Silent Mentor Program: Application of Buddhist Ethics to Teach Student Physicians Empathy, Compassion, and Self-Sacrifice.

      Science.gov (United States)

      Santibañez, Scott; Boudreaux, Debra; Tseng, Guo-Fang; Konkel, Kimberly

      2016-10-01

      The Buddhist Tzu Chi Silent Mentor Program promotes the donation of one's body to science as a selfless act by appealing to the Buddhist ethics of compassion and self-sacrifice. Together, faculty, families, and donors help medical students to learn the technical, spiritual, emotional, and psychological aspects of medicine. Students assigned to each "Silent Mentor" visit the family to learn about the donor's life. They see photos and hear family members' stories. Afterwards, students write a brief biography of the donor which is posted on the program website, in the medical school, and on the dissection table. In this paper, we: (1) summarize the Silent Mentor Program; (2) describe findings from an assessment of medical students who recently completed a new version of the program in Malaysia; and (3) explore how healthcare settings could benefit from this innovative program.

    14. Diagnosis of silent myocardial ischemia in type 2 diabetic patients by electrocardiogram, ergometry and Gated-SPECT

      International Nuclear Information System (INIS)

      Penna Quian, Yamile; Fernandez-Britto Rodriguez, Jose; Bacallao Gallestey, Jorge; Batista Cuellar, Juan Felipe; Coca Perez, Marco Antonio; Toirac Garcia, Noresma; Penna Coego, Andria

      2008-01-01

      31 asymptomatic type 2 diabetic patients were studied by lab tests, electrocardiogram, ergometry, Gated-SPECT and coronariography to determine the relation between the atherosclerotic risk factors and the silent myocardial ischemia. Patients were classified into two groups: positive SPECT and negative SPECT. Association tests were made for each variable and ROC curves were constructed to identify risk markers. In 35.5% of the patients silent myocardial ischemia was detected with a good angiographic correlation. A significant association was evidenced between positive SPECT and the atherosclerotic risk factors, namely, low values of HDLc, family pathological history of ischemic heart disease and peripheral vascular disease. The logistic regression models showed that low values of HDLc together with family pathological history of ischemic heart disease may be strong predictors of silent myocardial ischemia in asymptomatic type 2 diabetic patients

    15. Neocortical inhibitory activities and long-range afferents contribute to the synchronous onset of silent states of the neocortical slow oscillation.

      Science.gov (United States)

      Lemieux, Maxime; Chauvette, Sylvain; Timofeev, Igor

      2015-02-01

      During slow-wave sleep, neurons of the thalamocortical network are engaged in a slow oscillation (<1 Hz), which consists of an alternation between the active and the silent states. Several studies have provided insights on the transition from the silent, which are essentially periods of disfacilitation, to the active states. However, the conditions leading to the synchronous onset of the silent state remain elusive. We hypothesized that a synchronous input to local inhibitory neurons could contribute to the transition to the silent state in the cat suprasylvian gyrus during natural sleep and under ketamine-xylazine anesthesia. After partial and complete deafferentation of the cortex, we found that the silent state onset was more variable among remote sites. We found that the transition to the silent state was preceded by a reduction in excitatory postsynaptic potentials and firing probability in cortical neurons. We tested the impact of chloride-mediated inhibition in the silent-state onset. We uncovered a long-duration (100-300 ms) inhibitory barrage occurring about 250 ms before the silent state onset in 3-6% of neurons during anesthesia and in 12-15% of cases during natural sleep. These inhibitory activities caused a decrease in cortical firing that reduced the excitatory drive in the neocortical network. That chain reaction of disfacilitation ends up on the silent state. Electrical stimuli could trigger a network silent state with a maximal efficacy in deep cortical layers. We conclude that long-range afferents to the neocortex and chloride-mediated inhibition play a role in the initiation of the silent state. Copyright © 2015 the American Physiological Society.

    16. Microbial communication leading to the activation of silent fungal secondary metabolite gene clusters

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      Tina eNetzker

      2015-04-01

      Full Text Available Microorganisms form diverse multispecies communities in various ecosystems. The high abundance of fungal and bacterial species in these consortia results in specific communication between the microorganisms. A key role in this communication is played by secondary metabolites (SMs, which are also called natural products. Recently, it was shown that interspecies ‘talk’ between microorganisms represents a physiological trigger to activate silent gene clusters leading to the formation of novel SMs by the involved species. This review focuses on mixed microbial cultivation, mainly between bacteria and fungi, with a special emphasis on the induced formation of fungal SMs in co-cultures. In addition, the role of chromatin remodeling in the induction is examined, and methodical perspectives for the analysis of natural products are presented. As an example for an intermicrobial interaction elucidated at the molecular level, we discuss the specific interaction between the filamentous fungi Aspergillus nidulans and Aspergillus fumigatus with the soil bacterium Streptomyces rapamycinicus, which provides an excellent model system to enlighten molecular concepts behind regulatory mechanisms and will pave the way to a novel avenue of drug discovery through targeted activation of silent SM gene clusters through co-cultivations of microorganisms.

    17. High frequency of silent brain infarcts associated with cognitive deficits in an economically disadvantaged population.

      Science.gov (United States)

      Squarzoni, Paula; Tamashiro-Duran, Jaqueline H; Duran, Fabio L S; Leite, Claudia C; Wajngarten, Mauricio; Scazufca, Marcia; Menezes, Paulo R; Lotufo, Paulo A; Alves, Tania C T F; Busatto, Geraldo F

      2017-08-01

      Using magnetic resonance imaging, we aimed to assess the presence of silent brain vascular lesions in a sample of apparently healthy elderly individuals who were recruited from an economically disadvantaged urban region (São Paulo, Brazil). We also wished to investigate whether the findings were associated with worse cognitive performance. A sample of 250 elderly subjects (66-75 years) without dementia or neuropsychiatric disorders were recruited from predefined census sectors of an economically disadvantaged area of Sao Paulo and received structural magnetic resonance imaging scans and cognitive testing. A high proportion of individuals had very low levels of education (4 years or less, n=185; 21 with no formal education). The prevalence of at least one silent vascular-related cortical or subcortical lesion was 22.8% (95% confidence interval, 17.7-28.5), and the basal ganglia was the most frequently affected site (63.14% of cases). The subgroup with brain infarcts presented significantly lower levels of education than the subgroup with no brain lesions as well as significantly worse current performance in cognitive test domains, including memory and attention (pcognitive deficits, and in the absence of magnetic resonance imaging data, this cognitive impairment may be considered simply related to ageing. Emphatic attention should be paid to potentially deleterious effects of vascular brain lesions in poorly educated elderly individuals from economically disadvantaged environments.

    18. Deafening silence? Time to reconsider whether organisations are silent or deaf when things go wrong.

      Science.gov (United States)

      Jones, Aled; Kelly, Daniel

      2014-09-01

      Several public inquiries into healthcare failings in the UK have noted that employees of failing organizations attempt to raise concerns about shortcomings in care, often over a prolonged period of time, only for those concerns to be ignored. However, healthcare literature has largely focused on how organizations and their employees are silent in the face of such failings, positioning employees as daring not to speak in response to serious workplace problems or issues. We argue that only focussing on organizational silence is a critical mistake which misrepresents actual events and overly-simplifies the complexities of workplace culture. The disregard shown by academics, practitioners and policy makers to employee voice strategies, which do not amount to whistle-blowing, but equally cannot either be defined as "silence", results in signals being ignored that can be effective in preventing and ending wrongdoing by others. In addition to understanding silence we suggest therefore that better understanding of why organizations are deaf to, or disregard, employee concerns are needed. We propose that a virtuous cycle is possible, whereby the introduction of systems that result in better listening and valuing of employee concerns reinforces a culture of speaking up and, in turn, organizational learning. Similarly, organizations that disregard employees concerns are destined not to learn, ultimately falling silent and failing. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

    19. Direct effects of smoking on the heart: silent ischemic disturbances of coronary flow

      International Nuclear Information System (INIS)

      Deanfield, J.E.; Shea, M.J.; Wilson, R.A.; Horlock, P.; de Landsheere, C.M.; Selwyn, A.P.

      1986-01-01

      Cigarette smoking is strongly associated with ischemic heart disease and acute coronary events. The effect of smoking a single cigarette on regional myocardial perfusion was studied in 13 chronic smokers with typical stable angina pectoris using positron emission tomography and rubidium-82 ( 82 Rb). Findings were compared with the effects of physical exercise. After exercise, 8 patients (61%) had angina, ST depression and abnormal regional myocardial perfusion. Uptake of 82 Rb increased from 49 +/- 8 to 60 +/- 7 in remote myocardium, but decreased from 46 +/- 3 to 37 +/- 5 in an ischemic area. The remaining 5 patients (39%) had homogeneous increases in 82 Rb uptake without angina or ST depression. After smoking, 6 of the 8 patients with positive exercise test responses had a decrease in 82 Rb uptake, from 47 +/- 3 to 35 +/- 6 in the same segment of myocardium affected during exercise. However, in contrast to exercise, the events during smoking were largely silent. The absolute decreases in regional 82 Rb uptake after smoking occurred at significantly lower levels of myocardial oxygen demand than after exercise. This suggests that an impairment of coronary blood supply is responsible. Thus, in smokers with coronary artery disease, each cigarette can cause profound silent disturbances of regional myocardial perfusion that are likely to occur frequently during daily life. Such repeated insults may represent an important mechanism linking smoking with coronary events

    20. Public health response to the silent reintroduction of wild poliovirus to Israel, 2013-2014.

      Science.gov (United States)

      Moran-Gilad, J; Kaliner, E; Gdalevich, M; Grotto, I

      2016-12-01

      During 2013/14, Israel witnessed the silent reintroduction and sustained transmission of wild poliovirus type 1 (WPV1) detected through routine environmental surveillance performed on sewage samples. The public health response to silent poliovirus transmission in a population with high inactivated polio vaccine (IPV) coverage poses an emerging challenge towards the 'End Game' of global poliovirus eradication. This paper reviews the risk assessment, risk management and risk communication aspects of this poliovirus incident. Special emphasis is placed on the use of scientific data generated in the risk assessment phase to inform the public health response. Reintroducing a live vaccine in supplemental immunization activities in response to transmission of WPV or vaccine-derived poliovirus should be considered close to the 'End Game' of polio eradication, especially if targeting the population at risk is feasible. Such circumstances require a comprehensive contingency plan that will support the generation of important public health evidence at the risk assessment stage, thereby allowing to tailor the risk management approaches and underpin appropriate risk communication. Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

    1. THE EFFECT OF USING SHORT SILENT ANIMATIONS ON EFL LEARNERS WRITING

      Directory of Open Access Journals (Sweden)

      Hamid Marashi

      2017-06-01

      Full Text Available This study investigated the effect of short silent animations on pre-intermediate EFL learners writing. A homogenized group of 60 participants was non-randomly chosen and assigned as the control and experimental groups. Those in the control group watched five short animations with dialogue, while those in the experimental group had five short animations which were silent. The procedure lasted 10 sessions. In both groups, the participants were asked to write five writings regarding the subjects of the animations during the term and each of the writings should have contained a minimum of 90 and maximum of 140 words. The participants were provided both oral and written feedback. At the end of the instruction, a sample PET writing posttest was administered to both groups, an independent samples t-test was run on the mean scores of the two groups, and the results (t = -2.02, p = 0.037˂0.05 revealed that the experimental group outperformed the control group.

    2. Transformation of a Silent Adrencorticotrophic Pituitary Tumor Into Central Nervous System Melanoma

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      Brandon A. Miller MD, PhD

      2013-06-01

      Full Text Available Silent adrenocorticotrophic pituitary adenomas are nonfunctioning pituitary adenomas that express adrenocorticotrophic hormone (ACTH but do not cause the clinical or laboratory features of hypercortisolemia. Primary central nervous system (CNS melanoma is well documented, but rarely originates in the sellar region or pituitary gland. Here we report transformation of an aggressive silent adrenocorticotrophic pituitary adenoma that transformed into CNS melanoma and review other presentations of pituitary melanoma. A 37-year-old woman initially presented with apoplexy and an invasive nonfunctioning pituitary macroadenoma for which she underwent transphenoidal surgery. The patient underwent 3 subsequent surgeries as the tumor continued to progress. Pathology from the first 3 operations showed pituitary adenoma or carcinoma. Pathology from the final surgery showed melanoma and the magnetic resonance imaging characteristics of the tumor had changed to become consistent with CNS melanoma. Dermatologic and ophthalmologic examinations did not identify cutaneous or ocular melanoma. The patient’s disease progressed despite aggressive surgical, medical and radiologic treatment. To our knowledge, this is the first report demonstrating transformation of a primary pituitary tumor into melanoma. The mechanism of tumor transformation is unclear, but it is possible that a mutation in the original ACTH-producing tumor lead to increased cleavage of pro-opiomelanocortin or ACTH into α-melanocyte-stimulating hormone, which in turn stimulated the expression of microopthalmia transcription factor, leading to melanocytic phenotype transformation.

    3. Functional magnetic resonance imaging of hippocampal activation during silent mantra meditation.

      Science.gov (United States)

      Engström, Maria; Pihlsgård, Johan; Lundberg, Peter; Söderfeldt, Birgitta

      2010-12-01

      The objective of the present study was to investigate whether moderately experienced meditators activate hippocampus and the prefrontal cortex during silent mantra meditation, as has been observed in earlier studies on subjects with several years of practice. Subjects with less than 2 years of meditation practice according to the Kundalini yoga or Acem tradition were examined by functional magnetic resonance imaging during silent mantra meditation, using an on-off block design. Whole-brain as well as region-of-interest analyses were performed. The most significant activation was found in the bilateral hippocampus/parahippocampal formations. Other areas with significant activation were the bilateral middle cingulate cortex and the bilateral precentral cortex. No activation in the anterior cingulate cortex was found, and only small activation clusters were observed in the prefrontal cortex. In conclusion, the main finding in this study was the significant activation in the hippocampi, which also has been correlated with meditation in several previous studies on very experienced meditators. We propose that the hippocampus is activated already after moderate meditation practice and also during different modes of meditation, including relaxation. The role of hippocampal activity during meditation should be further clarified in future studies, especially by investigating whether the meditation-correlated hippocampal activity is related to memory consolidation.

    4. Impact of Insulin Resistance on Silent and Ongoing Myocardial Damage in Normal Subjects: The Takahata Study

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      Taro Narumi

      2012-01-01

      Full Text Available Background. Insulin resistance (IR is part of the metabolic syndrome (Mets that develops after lifestyle changes and obesity. Although the association between Mets and myocardial injury is well known, the effect of IR on myocardial damage remains unclear. Methods and Results. We studied 2200 normal subjects who participated in a community-based health check in the town of Takahata in northern Japan. The presence of IR was assessed by homeostasis model assessment ratio, and the serum level of heart-type fatty acid binding protein (H-FABP was measured as a maker of silent and ongoing myocardial damage. H-FABP levels were significantly higher in subjects with IR and Mets than in those without metabolic disorder regardless of gender. Multivariate logistic analysis showed that the presence of IR was independently associated with latent myocardial damage (odds ratio: 1.574, 95% confidence interval 1.1–2.3 similar to the presence of Mets. Conclusions. In a screening of healthy subjects, IR and Mets were similarly related to higher H-FABP levels, suggesting that there may be an asymptomatic population in the early stages of metabolic disorder that is exposed to myocardial damage and might be susceptible to silent heart failure.

    5. Chlamydia pneumoniae hides inside apoptotic neutrophils to silently infect and propagate in macrophages.

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      Jan Rupp

      Full Text Available BACKGROUND: Intracellular pathogens have developed elaborate strategies for silent infection of preferred host cells. Chlamydia pneumoniae is a common pathogen in acute infections of the respiratory tract (e.g. pneumonia and associated with chronic lung sequelae in adults and children. Within the lung, alveolar macrophages and polymorph nuclear neutrophils (PMN are the first line of defense against bacteria, but also preferred host phagocytes of chlamydiae. METHODOLOGY/PRINCIPAL FINDINGS: We could show that C. pneumoniae easily infect and hide inside neutrophil granulocytes until these cells become apoptotic and are subsequently taken up by macrophages. C. pneumoniae infection of macrophages via apoptotic PMN results in enhanced replicative activity of chlamydiae when compared to direct infection of macrophages, which results in persistence of the pathogen. Inhibition of the apoptotic recognition of C. pneumoniae infected PMN using PS- masking Annexin A5 significantly lowered the transmission of chlamydial infection to macrophages. Transfer of apoptotic C. pneumoniae infected PMN to macrophages resulted in an increased TGF-ss production, whereas direct infection of macrophages with chlamydiae was characterized by an enhanced TNF-alpha response. CONCLUSIONS/SIGNIFICANCE: Taken together, our data suggest that C. pneumoniae uses neutrophil granulocytes to be silently taken up by long-lived macrophages, which allows for efficient propagation and immune protection within the human host.

    6. Clinical aspects of silent cerebral infarction; MRI findings and its distribution

      Energy Technology Data Exchange (ETDEWEB)

      Ohnishi, Jiro (Kobe Univ. (Japan). School of Medicine); Kudo, Yutaka

      1991-06-01

      High-field MR scans have often showed patchy incidental findings especially in the elderly. We examined 91 patients, without episodes of cerebrovascular disorders previously, who had silent cerebral lesions noted by the 1.5 tesla superconductive system T2 weighted magnetic resonance imaging. They were divided into three subtypes by the localization of foci. The 23 subjects (25%) showed confined lesions to thalamus and/or internal capsule and/or basal ganglia (the basal ganglia type). The 39 subjects (43%) had lesions predominantly in cerebral cortex and/or subcortical white matter and/or cerebellum (the diffuse subcortical type). Finally, the 29 subjects (32%) had both features of abovementioned two groups (the mixed type). These subtypes were correlated with age, sex and some of the other risk factors, such as systolic blood pressure, diastolic blood pressure, serum total cholesterol and uric acid, for stroke. From the age extent and the correlation of subtypes to risk factors, the basal ganglia type was suspected to be based on the different origin from other two types. The authors proposed that the arteriosclerotic factor might play an important role in the incidence of the diffuse subcortical type and the mixed type silent cerebral infarctions and that the hemodynamic factor might play an important role in the incidence of the basal ganglia type. (J.P.N.).

    7. Measuring the prevalence of regional mutation rates: an analysis of silent substitutions in mammals, fungi, and insects

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      Tuch Brian B

      2008-06-01

      Full Text Available Abstract Background The patterns of mutation vary both within and across genomes. It has been shown for a few mammals that mutation rates vary within the genome, while for unknown reasons, the sensu stricto yeasts have uniform rates instead. The generality of these observations has been unknown. Here we examine silent site substitutions in a more expansive set (20 mammals, 27 fungi, 4 insects to determine why some genomes demonstrate this mosaic distribution and why others are uniform. Results We applied several intragene and intergene correlation tests to measure regional substitution patterns. Assuming that silent sites are a reasonable approximation to neutrally mutating sequence, our results show that all multicellular eukaryotes exhibit mutational heterogeneity. In striking contrast, all fungi are mutationally uniform – with the exception of three Candida species: C. albicans, C. dubliniensis, and C. tropicalis. We speculate that aspects of replication timing may be responsible for distinguishing these species. Our analysis also reveals classes of genes whose silent sites behave anomalously with respect to the mutational background in many species, indicating prevalent selective pressures. Genes associated with nucleotide binding or gene regulation have consistently low silent substitution rates in every mammalian species, as well as multiple fungi. On the other hand, receptor genes repeatedly exhibit high silent substitution rates, suggesting they have been influenced by diversifying selection. Conclusion Our findings provide a framework for understanding the regional mutational properties of eukaryotes, revealing a sharp difference between fungi and multicellular species. They also elucidate common selective pressures acting on eukaryotic silent sites, with frequent evidence for both purifying and diversifying selection.

    8. Bajo impacto de la infección silente por el virus de la hepatitis B en la incidencia de hepatitis postransfusional en Venezuela

      Directory of Open Access Journals (Sweden)

      Gutiérrez Cristina

      2001-01-01

      Full Text Available Objetivo. Detectar la presencia de ADN del VHB en sueros de donantes de sangre negativos en las pruebas de los marcadores serológicos de hepatitis B empleados en el tamizaje, con el fin de evaluar el impacto de la infección silente por VHB sobre la incidencia de hepatitis B postransfusional en Venezuela. Métodos. Los sueros de 2 075 donantes de sangre negativos en las pruebas de los marcadores serológicos pesquisados en bancos de sangre venezolanos fueron analizados en 53 muestras, compuestas por la mezcla de 25-50 donaciones (0,5-1,0 mL de cada suero. Estas fueron sometidos a ultracentrifugación previa a la extracción del ADN viral por el método de proteinasa K-fenol-cloroformo. Resultados. En estas mezclas de sueros no se detectó ADN del VHB en ninguno de dos ensayos anidados de reacción en cadena de la polimerasa, mediante cebadores altamente conservados de las regiones que codifican el antígeno de superficie y de la cápside virales. Se observaron niveles normales de aminotransferasas en 98% de 200 sueros evaluados. Conclusiones. Estos resultados sugieren que el riesgo de adquirir hepatitis B postransfusional en Venezuela es bajo.

    9. Cementos con cenizas volantes

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      Ossa M., Mauricio

      1984-03-01

      additions of 20 and 30% .

      Casi la generalidad de los estudios realizados sobre cementos con adición de cenizas volantes se refieren a sus características y comportamiento en pastas, morteros y hormigones, siempre en relación con aquéllos del cemento portland. Esta vez, se desarrolló un trabajo experimental orientado a relacionar entre sí los cementos con adiciones de cenizas volantes y de puzolana natural. Para ello se fabricaron a escala de laboratorio cementos de ambos tipos, empleando como materias primas comunes clinker y yeso y, como variables, diferentes porcentajes de las dos adiciones, que cumplieron previamente los requisitos normalizados en cuanto a sus actividades puzolánicas. La calidad de los cementos fabricados resultó adecuada y concordante con la del cemento portland-puzolánico obtenido a escala industrial con los mismos clinker, yeso y puzolana natural de este estudio. Posteriormente, se determinaron las características de los cementos experimentales y se confeccionaron morteros normales para la realización de ensayos físicos y mecánicos. Los resultados de ensayos indicaron que los cementos con adición de cenizas volantes (CCV requieren menos agua para consistencia normal, presentan tiempos de fraguado mayores y expansiones en autoclave menores que los cementos con adición de puzolana (CP. Los calores de hidratación a 7 y 28 días de edad fueron aproximadamente similares para ambos tipos de cemento. En morteros normales, los cementos CCV mostraron menor retracción de secado, mayor retentividad y mayor fluidez (para igual cantidad de agua que los cementos CP. En los ensayos de exudación se observó que ésta depende más de la finura que el tipo de adición. Finalmente, los ensayos mecánicos señalaron que las resistencias a compresión y flexotracción de los morteros con cementos CCV son menores a edades inferiores que 14 días (del orden de 5 a 10% a un día de edad, pero que a partir de entonces pasan a ser mayores que las de

    10. “Silent” Diabetes and Clinical Outcome After Treatment With Contemporary Drug-Eluting Stents : The BIO-RESORT Silent Diabetes Study

      NARCIS (Netherlands)

      von Birgelen, Clemens; Kok, Marlies M.; Sattar, Naveed; Zocca, Paolo; Doelman, Cees; Kant, Gert D.; Löwik, Marije M.; van der Heijden, Liefke C.; Sen, Hanim; van Houwelingen, Gert K.; Stoel, Martin G.; Louwerenburg, J. (Hans) W.; Hartmann, Marc; de Man, Frits H.A.F.; Linssen, Gerard C.M.; Doggen, Carine J.M.; Tandjung, Kenneth

      2018-01-01

      Objectives: This study sought to assess the prevalence and clinical impact of silent diabetes and pre-diabetes in “nondiabetic” percutaneous coronary intervention (PCI) all-comers. Background: Patients with undetected and thus untreated (silent) diabetes may have higher event risks after PCI with

    11. competencia con China

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      Elena de la Paz Hernández Águila

      2007-01-01

      Full Text Available El artículo ofrece un diagnóstico del desempeño de la industria mexicana del calzado desde la década de los ochenta hasta la actualidad. Analiza la problemática que ha enfrentado esta rama industrial a partir del proceso de apertura comercial y de la competencia en su mercado interno con productos provenientes de países asiáticos, particularmente China. Problematiza al respecto los retos y las perspectivas que a mediano plazo enfrentará este sector empresarial y sobre las posibilidades de competir en el mercado globalizado.

    12. Construir con Madera

      OpenAIRE

      Olabe-Velasco, F. (Fermín); Val-Hernández, Y. (Yolanda); Varela-de-la-Cruz, P. (Perla); Cabrero-Ballarín, J.M. (José Manuel)

      2010-01-01

      Guía divulgativa ‘Construir con madera’, elaborada por la Cátedra Madera de la Universidad de Navarra y el Gobierno de Navarra. La publicación pretende explicar de forma sencilla los beneficios y posibilidades de este material en la construcción, tanto en lo que respecta a su resistencia, comportamiento frente al fuego, durabilidad, capacidad de aislamiento, propiedades acústicas, estética, respeto al medio ambiente y sostenibilidad como fuente de energía. A modo de ejemplo, en la ...

    13. Entrevista con Giovanni Levi

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      Monica Oliveira

      2017-06-01

      Full Text Available En esta entrevista, Giovanni Levi - como un conocedor del tema de Familia - realiza una importante evaluación sobre el actual estado de las investigaciones realizadas en el Brasil y em el exterior. Con estilo franco, agudo y lucido critica las visiones tradicionales y sus ilusiones ypropone nuevos conceptos y métodos. La historia de la familia debería ceder espacio para el estudio de las redes relacionales o de los mundos relacionales. De la misma forma, la historia cuantitativa debería abrir espacio para el estudio de las cualidades. Ya con relación a la historia de las elites, tan estudiada y reproducida en una diversidad de trabajos, que deberíase mirar en otra perspectiva. Es decir, no mirar a las reglas sociales predeterminadas, sino a los desvíos y a las variaciones. Levi defiende que los historiadores deben trascender a los documentos que se encuentran fácilmente y que pueden fortalecer perspectivas deformadas y esequilibradas de la sociedad. Para él, los historiadores deben esforzarse por estudiar a aquellos grupos que dejaron pocos rastros documentales. En ese esfuerzo existiría una nueva mirada sobre la historia de la familia.

    14. Entrevista con Patricia Ariza

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      Esperanza Londoño La Rotta

      2017-01-01

      Full Text Available Pensamiento, Palabra y Obra entrevista a una artista, feminista y activista política, quien como mujer y artista ha permitido pensar el arte más allá de un simple espectáculo. Toda una vida dedicada al teatro y a darle voz, a través de sus obras, a víctimas del conflicto colombiano, defensora de derechos humanos; además de hacer evidente en su vida y a través de la plataforma “Artistas por la paz”, las múltiples relaciones que se pueden establecer entre el arte, la construcción de paz y la resolución de conflictos. Hablamos en su casa, en medio del calor de la bienvenida con Patricia Ariza, directora del festival alternativo de teatro, de Mujeres en Escena y de la Corporación Colombiana de Teatro, entre otras muchas actividades que voluntariamente su espíritu libertario ha asumido. Esta entrevista se realizó antes del 2 de octubre, pero con la revisión de los acuerdos que propició el plebiscito ganado por una ínfima minoría por el no, sigue siendo vigente este planteamiento.

    15. Cardiovascular risk evaluation and prevalence of silent myocardial ischemia in subjects with asymptomatic carotid artery disease

      Directory of Open Access Journals (Sweden)

      Ciccone M

      2011-03-01

      Full Text Available Marco Matteo Ciccone1, Artor Niccoli-Asabella2, Pietro Scicchitano1, Michele Gesualdo1, Antonio Notaristefano2, Domenico Chieppa1, Santa Carbonara1, Gabriella Ricci1, Marco Sassara1, Corinna Altini2, Giovanni Quistelli1, Mario Erminio Lepera1, Stefano Favale1, Giuseppe Rubini21Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO, 2Nuclear Medicine Unit, Department of Internal Medicine and of Public Medicine, University of Bari, Bari, ItalyIntroduction: Silent ischemia is an asymptomatic form of myocardial ischemia, not associated with angina or anginal equivalent symptoms, which can be demonstrated by changes in ECG, left ventricular function, myocardial perfusion, and metabolism. The aim of this study was to evaluate the prevalence of silent myocardial ischemia in a group of patients with asymptomatic carotid stenosis.Methods: A total of 37 patients with asymptomatic carotid plaques, without chest pain or dyspnea, was investigated. These patients were studied for age, sex, hypertension, diabetes, dyslipidemia, smoking, and family history of cardiac disease, and underwent technetium-99 m sestamibi myocardial stress-rest scintigraphy and echo-color Doppler examination of carotid arteries.Results: A statistically significant relationship (P = 0.023 was shown between positive responders and negative responders to scintigraphy test when both were tested for degree of stenosis. This relationship is surprising in view of the small number of patients in our sample. Individuals who had a positive scintigraphy test had a mean stenosis degree of 35% ± 7% compared with a mean of 44% ± 13% for those with a negative test. Specificity of our detection was 81%, with positive and negative predictive values of 60% and 63%, respectively.Conclusion: The present study confirms that carotid atherosclerosis is associated with coronary atherosclerosis and highlights the importance of screening for ischemic heart disease in

    16. Silent Corticotroph Adenomas After Stereotactic Radiosurgery: A Case–Control Study

      Energy Technology Data Exchange (ETDEWEB)

      Xu, Zhiyuan; Ellis, Scott; Lee, Cheng-Chia; Starke, Robert M. [Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia (United States); Schlesinger, David [Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia (United States); Department of Radiation Oncology, University of Virginia, Charlottesville, Virginia (United States); Lee Vance, Mary [Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia (United States); Department of Internal Medicine, University of Virginia, Charlottesville, Virginia (United States); Lopes, M. Beatriz [Division of Neuropathology, University of Virginia, Charlottesville, Virginia (United States); Sheehan, Jason, E-mail: jsheehan@virginia.edu [Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia (United States); Department of Radiation Oncology, University of Virginia, Charlottesville, Virginia (United States)

      2014-11-15

      Purpose: To investigate the safety and effectiveness of stereotactic radiosurgery (SRS) in patients with a silent corticotroph adenoma (SCA) compared with patients with other subtypes of non–adrenocorticotropic hormone staining nonfunctioning pituitary adenoma (NFA). Methods and Materials: The clinical features and outcomes of 104 NFA patients treated with SRS in our center between September 1994 and August 2012 were evaluated. Among them, 34 consecutive patients with a confirmatory SCA were identified. A control group of 70 patients with other subtypes of NFA were selected for review based on comparable baseline features, including sex, age at the time of SRS, tumor size, margin radiation dose to the tumor, and duration of follow-up. Results: The median follow-up after SRS was 56 months (range, 6-200 months). No patients with an SCA developed Cushing disease during the follow-up. Tumor control was achieved in 21 of 34 patients (62%) in the SCA group, compared with 65 of 70 patients (93%) in the NFA group. The median progression-free survival (PFS) was 58 months in the SCA group. The actuarial PFS was 73%, 46%, and 31% in the SCA group and was 94%, 87%, and 87% in the NFA group at 3, 5, and 8 years, respectively. Silent corticotroph adenomas treated with a dose of ≥17 Gy exhibited improved PFS. New-onset loss of pituitary function developed in 10 patients (29%) in the SCA group, whereas it occurred in 18 patients (26%) in the NFA group. Eight patients (24%) in the SCA group experienced worsening of a visual field deficit or visual acuity attributed to the tumor progression, as did 6 patients (9%) in the NFA group. Conclusion: Silent corticotroph adenomas exhibited a more aggressive course with a higher progression rate than other subtypes of NFAs. Stereotactic radiosurgery is an important adjuvant treatment for control of tumor growth. Increased radiation dose may lead to improved tumor control in SCA patients.

    17. Silent Corticotroph Adenomas After Stereotactic Radiosurgery: A Case–Control Study

      International Nuclear Information System (INIS)

      Xu, Zhiyuan; Ellis, Scott; Lee, Cheng-Chia; Starke, Robert M.; Schlesinger, David; Lee Vance, Mary; Lopes, M. Beatriz; Sheehan, Jason

      2014-01-01

      Purpose: To investigate the safety and effectiveness of stereotactic radiosurgery (SRS) in patients with a silent corticotroph adenoma (SCA) compared with patients with other subtypes of non–adrenocorticotropic hormone staining nonfunctioning pituitary adenoma (NFA). Methods and Materials: The clinical features and outcomes of 104 NFA patients treated with SRS in our center between September 1994 and August 2012 were evaluated. Among them, 34 consecutive patients with a confirmatory SCA were identified. A control group of 70 patients with other subtypes of NFA were selected for review based on comparable baseline features, including sex, age at the time of SRS, tumor size, margin radiation dose to the tumor, and duration of follow-up. Results: The median follow-up after SRS was 56 months (range, 6-200 months). No patients with an SCA developed Cushing disease during the follow-up. Tumor control was achieved in 21 of 34 patients (62%) in the SCA group, compared with 65 of 70 patients (93%) in the NFA group. The median progression-free survival (PFS) was 58 months in the SCA group. The actuarial PFS was 73%, 46%, and 31% in the SCA group and was 94%, 87%, and 87% in the NFA group at 3, 5, and 8 years, respectively. Silent corticotroph adenomas treated with a dose of ≥17 Gy exhibited improved PFS. New-onset loss of pituitary function developed in 10 patients (29%) in the SCA group, whereas it occurred in 18 patients (26%) in the NFA group. Eight patients (24%) in the SCA group experienced worsening of a visual field deficit or visual acuity attributed to the tumor progression, as did 6 patients (9%) in the NFA group. Conclusion: Silent corticotroph adenomas exhibited a more aggressive course with a higher progression rate than other subtypes of NFAs. Stereotactic radiosurgery is an important adjuvant treatment for control of tumor growth. Increased radiation dose may lead to improved tumor control in SCA patients

    18. Dynamic wind turbine models in power system simulation tool DIgSILENT

      Energy Technology Data Exchange (ETDEWEB)

      Hansen, A.D.; Iov, F.; Soerensen, Poul.; Cutululis, N.; Jauch, C.; Blaabjerg, F.

      2007-08-15

      This report presents a collection of models and control strategies developed and implemented in the power system simulation tool PowerFactory DIgSILENT for different wind turbine concepts. It is the second edition of Risoe-R-1400(EN) and it gathers and describes a whole wind turbine model database built-op and developed during several national research projects, carried out at Risoe DTU National Laboratory for Sustainable Energy and Aalborg University, in the period 2001-2007. The overall objective of these projects was to create a wind turbine model database able to support the analysis of the interaction between the mechanical structure of the wind turbine and the electrical grid during different operational modes. The report provides thus a description of the wind turbines modelling, both at a component level and at a system level. The report contains both the description of DIgSILENT built-in models for the electrical components of a grid connected wind turbine (e.g. induction generators, power converters, transformers) and the models developed by the user, in the dynamic simulation language DSL of DIgSILENT, for the non-electrical components of the wind turbine (wind model, aerodynamic model, mechanical model). The initialisation issues on the wind turbine models into the power system simulation are also presented. The main attention in the report is drawn to the modelling at the system level of the following wind turbine concepts: (1) Fixed speed active stall wind turbine concept (2) Variable speed doubly-fed induction generator wind turbine concept (3) Variable speed multi-pole permanent magnet synchronous generator wind turbine concept These wind turbine concept models can be used and even extended for the study of different aspects, e.g. the assessment of power quality, control strategies, connection of the wind turbine at different types of grid and storage systems. Different control strategies have been developed and implemented for these wind turbine

    19. Prevalencia de cardiopatía isquémica asintomática en pacientes con diabetes mellitus tipo 2

      Directory of Open Access Journals (Sweden)

      Dulman O. Pineda-De Paz

      2018-03-01

      Full Text Available Resumen: Introducción: La enfermedad cardiovascular es la causa principal de muerte en pacientes con diabetes mellitus. La prevalencia de cardiopatía isquémica asintomática es más alta en pacientes diabéticos que en no diabéticos y se asocia a peor pronóstico. Objetivo: Identificar la prevalencia de cardiopatía isquémica asintomática en pacientes con diabetes mellitus tipo 2 en un hospital de tercer nivel de atención de Guatemala y analizar la posible asociación de dicha enfermedad con características epidemiológicas, clínicas y metabólicas. Métodos: Estudio de corte transversal en el que se estudió una muestra de 92 pacientes diabéticos seleccionados de forma aleatoria simple. Se realizó electrocardiograma, que cuando fue negativo para isquemia ameritó prueba de esfuerzo, o de lo contrario, ecocardiograma de estrés con dobutamina. Resultados: La edad media de los participantes fue de 57 años, 88% de los cuales eran mujeres; la duración media de la diabetes fue 7 años. Se encontró cardiopatía isquémica asintomática en el 22,8% de los casos. No se hallaron posibles asociaciones entre cardiopatía isquémica asintomática y edad, sexo, enfermedad arterial periférica, índice de masa corporal, índice tobillo-brazo, hipertensión arterial, dislipidemia, tabaquismo activo, sedentarismo, sobrepeso/obesidad, alcoholismo, glucosa en ayunas, hemoglobina glicosilada, colesterol total, colesterol HDL, colesterol LDL, ácido úrico, creatinina, tasa de filtrado glomerular y microalbuminuria. Conclusiones: La prevalencia de cardiopatía isquémica asintomática en la población estudiada con diabetes mellitus tipo 2 fue de 22,8%. No se encontraron posibles asociaciones de cardiopatía isquémica asintomática con las variables estudiadas. Abstract: Introduction: Cardiovascular disease is the main cause of death in patients with diabetes mellitus. The prevalence of asymptomatic ischaemic heart disease is higher in diabetic

    20. Case Report: Anteromedial temporosphenoidal encephalocele with a clinically silent lateral bony defect in the greater wing of the sphenoid

      International Nuclear Information System (INIS)

      Pandey, Anoop Kumar

      2009-01-01

      Anteromedial temporosphenoidal encephalocele is the least common type of temporal encephalocele. It commonly presents with spontaneous cerebrospinal fluid rhinorrhea in adults. This article presents the CT cisternography and MRI findings of one such case, which also had an associated clinically silent defect in the greater wing of the sphenoid on the same side

    1. Case Report: Anteromedial temporosphenoidal encephalocele with a clinically silent lateral bony defect in the greater wing of the sphenoid

      Directory of Open Access Journals (Sweden)

      Pandey Anoop

      2009-01-01

      Full Text Available Anteromedial temporosphenoidal encephalocele is the least common type of temporal encephalocele. It commonly presents with spontaneous cerebrospinal fluid rhinorrhea in adults. This article presents the CT cisternography and MRI findings of one such case, which also had an associated clinically silent defect in the greater wing of the sphenoid on the same side.

    2. The Effects of the Sustained Silent Reading Program on Cultivating Students' Habits and Attitudes in Reading Books for Leisure

      Science.gov (United States)

      Chua, Siah Poh

      2008-01-01

      The author examines the effects of the sustained silent reading program on cultivating students' habits and attitudes in reading books for leisure. The author used a time-series design and measured students' reading habits and attitudes three times in twelve months. It was expected that if the program created positive effects on cultivating…

    3. The silent information regulator 1 (Sirt1) is a positive regulator of the Notch pathway in Drosophila

      Czech Academy of Sciences Publication Activity Database

      Horváth, Matěj; Mihajlović, Zorana; Slaninová, Věra; Perez-Gomez, Raquel; Moshkin, Y.; Krejčí, Alena

      2016-01-01

      Roč. 473, č. 22 (2016), s. 4129-4143 ISSN 0264-6021 R&D Projects: GA ČR(CZ) GA14-08583S Institutional support: RVO:60077344 Keywords : Drosophila * silent information regulator 1 * Notch pathway Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.797, year: 2016

    4. Towards Contactless Silent Speech Recognition Based on Detection of Active and Visible Articulators Using IR-UWB Radar.

      Science.gov (United States)

      Shin, Young Hoon; Seo, Jiwon

      2016-10-29

      People with hearing or speaking disabilities are deprived of the benefits of conventional speech recognition technology because it is based on acoustic signals. Recent research has focused on silent speech recognition systems that are based on the motions of a speaker's vocal tract and articulators. Because most silent speech recognition systems use contact sensors that are very inconvenient to users or optical systems that are susceptible to environmental interference, a contactless and robust solution is hence required. Toward this objective, this paper presents a series of signal processing algorithms for a contactless silent speech recognition system using an impulse radio ultra-wide band (IR-UWB) radar. The IR-UWB radar is used to remotely and wirelessly detect motions of the lips and jaw. In order to extract the necessary features of lip and jaw motions from the received radar signals, we propose a feature extraction algorithm. The proposed algorithm noticeably improved speech recognition performance compared to the existing algorithm during our word recognition test with five speakers. We also propose a speech activity detection algorithm to automatically select speech segments from continuous input signals. Thus, speech recognition processing is performed only when speech segments are detected. Our testbed consists of commercial off-the-shelf radar products, and the proposed algorithms are readily applicable without designing specialized radar hardware for silent speech processing.

    5. Variability in State-Based Recommendations for Management of Alpha Thalassemia Trait and Silent Carrier Detected on the Newborn Screen.

      Science.gov (United States)

      Fogel, Benjamin N; Nguyen, Hong Loan T; Smink, Gayle; Sekhar, Deepa L

      2018-04-01

      We conducted an inventory of state-based recommendations for follow-up of alpha thalassemia silent carrier and trait identified on newborn screen. We found wide variability in the nature and timing of these recommendations. We recommend a standardized recommendation to guide pediatricians in evidenced-based care for this population. Copyright © 2017 Elsevier Inc. All rights reserved.

    6. Altered Modulation of Silent Period in Tongue Motor Cortex of Persistent Developmental Stuttering in Relation to Stuttering Severity.

      Science.gov (United States)

      Busan, Pierpaolo; Del Ben, Giovanni; Bernardini, Simona; Natarelli, Giulia; Bencich, Marco; Monti, Fabrizio; Manganotti, Paolo; Battaglini, Piero Paolo

      2016-01-01

      Motor balance in developmental stuttering (DS) was investigated with Transcranial Magnetic Stimulation (TMS), with the aim to define novel neural markers of persistent DS in adulthood. Eleven DS adult males were evaluated with TMS on tongue primary motor cortex, compared to 15 matched fluent speakers, in a "state" condition (i.e. stutterers vs. fluent speakers, no overt stuttering). Motor and silent period thresholds (SPT), recruitment curves, and silent period durations were acquired by recording tongue motor evoked potentials. Tongue silent period duration was increased in DS, especially in the left hemisphere (Pstuttering severity. Pre-TMS electromyography data gave overlapping evidence. Findings suggest the existence of a complex intracortical balance in DS tongue primary motor cortex, with a particular interplay between excitatory and inhibitory mechanisms, also in neural substrates related to silent periods. Findings are discussed with respect to functional and structural impairments in stuttering, and are also proposed as novel neural markers of a stuttering "state" in persistent DS, helping to define more focused treatments (e.g. neuro-modulation).

    7. Implementation of IEC Generic Model of Type 1 Wind Turbine Generator in DIgSILENT PowerFactory

      DEFF Research Database (Denmark)

      Zhao, Haoran; Wu, Qiuwei; Margaris, Ioannis

      2013-01-01

      The implementation method for the International Electrotechnical Commission (IEC) generic models of Type 1 wind turbine generator (WTG) in DIgSILENT PowerFactory is presented. The following items are described, i.e. model structure, model blocks and how to implement these blocks in the PowerFactory...

    8. Silent films and strange stories: theory of mind, gender, and social experiences in middle childhood.

      Science.gov (United States)

      Devine, Rory T; Hughes, Claire

      2013-01-01

      In this study of two hundred and thirty 8- to 13-year-olds, a new "Silent Films" task is introduced, designed to address the dearth of research on theory of mind in older children by providing a film-based analogue of F. G. E. Happé's (1994) Strange Stories task. Confirmatory factor analysis showed that all items from both tasks loaded onto a single theory-of-mind latent factor. With effects of verbal ability and family affluence controlled, theory-of-mind latent factor scores increased significantly with age, indicating that mentalizing skills continue to develop through middle childhood. Girls outperformed boys on the theory-of-mind latent factor, and the correlates of individual differences in theory of mind were gender specific: Low scores were related to loneliness in girls and to peer rejection in boys. © 2012 The Authors. Child Development © 2012 Society for Research in Child Development, Inc.

    9. Treatment of Egyptian Maghara coal by plasma ozone synthesized by silent discharge

      CERN Document Server

      Salem, M A; Garamoon, A A; Hassouba, M A

      2003-01-01

      A sample of pyrite rich bituminous coal collected from the main coal seam of Maghara mine, northern sinai, was treated by ozone plasma. The latter was synthesized using silent discharge method (10 kv a.c. and 50 hz). The room temperature Moessbauer spectra of untreated coal sample was easily fitted to two doublet, whose parameters matched those of pyrite (FeS sub 2) and sulfate (FeSO sub 4.H sub 2 O) in addition to hematite. After treatment by ozone plasma, a doublet ascribed to pyrite was observed. The extent of pyrite oxidation to jarosite (Fe sub 2 (SO sub 4) sub 3. nH sub 2 O) was monitored by their relative spectral areas, the incomplete oxidation of pyrite may be attributed to the presence of calcium sulfate layer which acts a screen of ozone.

    10. Analysis of a silent voice: a qualitative inquiry of embroidery created by a patient with schizophrenia.

      Science.gov (United States)

      Blakeman, John R; Samuelson, Sheryl J; McEvoy, Kimberly N

      2013-06-01

      A poster-sized piece of embroidery, completed in the 1960s, hangs in the Glore Psychiatric Museum, a testament to the daily experience of a woman who rarely spoke and was diagnosed with schizophrenia. The embroidery document was analyzed by three researchers who came to agreement on themes via triangulation and constant comparison. The woman's lived experience was considered. The analysis found that although the patient was silent, she was connected in interesting ways to the environment around her. Implications for nursing care include awareness of the importance of milieu to patients, that silence should not be inferred to be detachment, and nurses should continue to develop creative ways to engage patients who may communicate in nontraditional ways. Copyright 2013, SLACK Incorporated.

    11. Enteropathy-associated T cell lymphoma as a complication of silent celiac disease

      Directory of Open Access Journals (Sweden)

      Margarida Dantas Brito

      2014-12-01

      Full Text Available Celiac disease is an autoimmune disorder in which a genetic predisposition and the ingestion of wheat gluten triggers a deleterious immune response. This response is complex and may lead to manifestations other than enteropathyha: hepatitis, dermatitis and neuropathy. There is higher risk for neoplasia. We observed an atypical case, corresponding to a 69-year old female presenting with complicated celiac disease. The patient was referred following the histological examination of an enterectomy specimen, which unexpectedly revealed an enteropathy-associated T cell lymphoma in a background of celiac disease. Patient’s previous medical history comprised several abdominal surgical procedures, without other prior symptoms suggestive of celiac disease. Indeed, the patient was obese and no signs of malabsortion were apparent. This case draws our attention to clinically silent celiac disease, which represents a diagnostic challenge. Thus, this should be kept in mind whenever a patient presents with abdominal relapsing complications, otherwise unexplained.

    12. Rape Survivors' Experiences of the Silent Protest: Implications for Promoting Healing and Resilience.

      Science.gov (United States)

      Padmanabhanunni, Anita; Edwards, David

      2016-05-01

      This article examines the experiences of nine rape survivors who participated in the Silent Protest, an annual protest march at Rhodes University that aims to highlight the sexual abuse of women, validate the harm done, and foster solidarity among survivors. Participants responded to a semi-structured interview focusing on the context of their rape and its impact, and their experiences of participation in the Protest In the first phase of data analysis, synoptic case narratives were written. In the second, themes from participants' experience were identified using interpretative phenomenological analysis. In the third, the data were examined in light of questions around the extent to which participation contributed to healing. Participants reported experiences of validation and empowerment but the majority were suffering from posttraumatic stress disorder. In some cases, participation had exacerbated self-blame and avoidant coping. Recommendations are made about the provision of psychoeducation and counseling at such events. © The Author(s) 2015.

    13. Occurrence of silent cerebral infarction in pre-senile, senile subjects with depressive states

      International Nuclear Information System (INIS)

      Fujikawa, Tokumi; Yamawaki, Shigeto; Touhouda, Yoshikuni.

      1993-01-01

      We examined the relationship between pre-senile, senile depressive states and silent cerebral infarction (SCI) using magnetic resonance imaging (MRI). The diagnostic criteria of major depression according to DSM-3-R was used to diagnose. Patients in whom stroke had occurred or who had local neurologic symptoms were not included. About half of the patients with depressive states of pre-senile onset and most of the patients with those of senile onset had SCI, were considered to be organic-depressive states complicated with SCI. Because patients with depressive states with SCI are at high risk of occurrence of stroke, we designated this condition 'pre-stroke depression', and classified it with endogenous depression. At this time, it is important to begin therapy for cerebrovascular disease. (author)

    14. Silent film: The Carlsberg Foundation’s Oceanographic Expedition Round the World, 1928–30

      DEFF Research Database (Denmark)

      Poulsen, Bo

      2016-01-01

      the surveys conducted onboard, as well as encounters with local populations round the World. This silent film consists of c. 20 different sequences. There is a very instructive introduction to the fishing gear, as it is being deployed in the sea, although this is supplemented by camera shots from what......Danish marine scientist, Johannes Schmidt was also a pioneer when it comes to popularizing deep-sea marine research through the use of mass media. When Schmidt headed the Carlsberg Foundation’s Oceanographical Expedition Round the World, 1928-1930, he brought along a film camera, documenting...... is clearly an aquarium, where the functioning of the water sampler is shown in action. As the Dana moves into the Pacific Ocean the focus of the film also changes. In the sections from the Pacific and Indian Oceans the film includes captions describing the local inhabitants of the Polynesian islands...

    15. Punctuation and Implicit Prosody in Silent Reading: An ERP Study Investigating English Garden-Path Sentences.

      Science.gov (United States)

      Drury, John E; Baum, Shari R; Valeriote, Hope; Steinhauer, Karsten

      2016-01-01

      This study presents the first two ERP reading studies of comma-induced effects of covert (implicit) prosody on syntactic parsing decisions in English. The first experiment used a balanced 2 × 2 design in which the presence/absence of commas determined plausibility (e.g., John, said Mary, was the nicest boy at the party vs. John said Mary was the nicest boy at the party ). The second reading experiment replicated a previous auditory study investigating the role of overt prosodic boundaries in closure ambiguities (Pauker et al., 2011). In both experiments, commas reliably elicited CPS components and generally played a dominant role in determining parsing decisions in the face of input ambiguity. The combined set of findings provides further evidence supporting the claim that mechanisms subserving speech processing play an active role during silent reading.

    16. Harmonic Domain Modelling of Transformer Core Nonlinearities Using the DIgSILENT PowerFactory Software

      DEFF Research Database (Denmark)

      Bak, Claus Leth; Bak-Jensen, Birgitte; Wiechowski, Wojciech

      2008-01-01

      This paper demonstrates the results of implementation and verification of an already existing algorithm that allows for calculating saturation characteristics of singlephase power transformers. The algorithm was described for the first time in 1993. Now this algorithm has been implemented using...... the DIgSILENT Programming Language (DPL) as an external script in the harmonic domain calculations of a power system analysis tool PowerFactory [10]. The algorithm is verified by harmonic measurements on a single-phase power transformer. A theoretical analysis of the core nonlinearities phenomena...... in single and three-phase transformers is also presented. This analysis leads to the conclusion that the method can be applied for modelling nonlinearities of three-phase autotransformers....

    17. Punctuation and Implicit Prosody in Silent Reading: An ERP Study Investigating English Garden-Path Sentences

      Science.gov (United States)

      Drury, John E.; Baum, Shari R.; Valeriote, Hope; Steinhauer, Karsten

      2016-01-01

      This study presents the first two ERP reading studies of comma-induced effects of covert (implicit) prosody on syntactic parsing decisions in English. The first experiment used a balanced 2 × 2 design in which the presence/absence of commas determined plausibility (e.g., John, said Mary, was the nicest boy at the party vs. John said Mary was the nicest boy at the party). The second reading experiment replicated a previous auditory study investigating the role of overt prosodic boundaries in closure ambiguities (Pauker et al., 2011). In both experiments, commas reliably elicited CPS components and generally played a dominant role in determining parsing decisions in the face of input ambiguity. The combined set of findings provides further evidence supporting the claim that mechanisms subserving speech processing play an active role during silent reading. PMID:27695428

    18. Punctuation and implicit prosody in silent reading: An ERP study investigating English garden-path sentences

      Directory of Open Access Journals (Sweden)

      John E. Drury

      2016-09-01

      Full Text Available This study presents the first two ERP reading studies of comma-induced effects of covert (implicit prosody on syntactic parsing decisions in English. The first experiment used a balanced 2 x 2 design in which the presence/absence of commas determined plausibility (e.g., John, said Mary, was the nicest boy at the party versus John said Mary was the nicest boy at the party. The second reading experiment replicated a previous auditory study investigating the role of overt prosodic boundaries in closure ambiguities (Pauker et al., 2011. In both experiments, commas reliably elicited CPS components and generally played a dominant role in determining parsing decisions in the face of input ambiguity. The combined set of findings provides further evidence supporting the claim that mechanisms subserving speech processing play an active role during silent reading.

    19. Modeling of the wind power plant using software DIgSILENT Power factory

      International Nuclear Information System (INIS)

      Mladenovski, Ljubisha; Iliev, Atanas; Fushtikj, Vangel

      2004-01-01

      This paper presents a method for creating a model of the wind power plant NORDEX N-60 in the DIgSILENT Power factory software. At the beginning, the characteristics of the wind power plant and the used software are shortly described. The next step is modeling the part of the power system where the wind power plant will be connected to the grid The modeling of the turbine part and the generator part of the wind power plant is made with blocks, which are part of the machine block of the composite model. Finally, the results obtained from performed practically oriented simulations are presented in graphical form. Design of the model of the wind power plant NORDEX N-60 was performed at the Faculty of Electrical Engineering, at the University of Rostock, Germany, as a part of the DYSIMAC project. (Author)

    20. Clinically silent subdural hemorrhage causes bilateral vocal fold paralysis in newborn infant.

      Science.gov (United States)

      Alshammari, Jaber; Monnier, Yan; Monnier, Philippe

      2012-10-01

      Bilateral congenital vocal fold paralysis (BVFP) may result from multiple etiologies or remain idiopathic when no real cause can be identified. If obstructive dyspnea is significant and requires urgent stabilization of the airway, then intubation is performed first and an MRI of the brain is conducted to rule out an Arnold-Chiari malformation that can benefit from a shunt procedure and thus alleviate the need for a tracheostomy. Clinically silent subdural hemorrhage without any birth trauma represents another cause of neonatal BVFP that resolves spontaneously within a month. It is of clinical relevance to recognize this potential cause of BVFP as its short duration may alleviate the need for a tracheostomy. In this article, we present such a case and review the literature to draw the otolaryngologist's attention to this possible etiology. Copyright © 2012. Published by Elsevier Ireland Ltd.

    1. A cost-effectiveness analysis of screening for silent atrial fibrillation after ischaemic stroke.

      Science.gov (United States)

      Levin, Lars-Åke; Husberg, Magnus; Sobocinski, Piotr Doliwa; Kull, Viveka Frykman; Friberg, Leif; Rosenqvist, Mårten; Davidson, Thomas

      2015-02-01

      The purpose of this study was to estimate the cost-effectiveness of two screening methods for detection of silent AF, intermittent electrocardiogram (ECG) recordings using a handheld recording device, at regular time intervals for 30 days, and short-term 24 h continuous Holter ECG, in comparison with a no-screening alternative in 75-year-old patients with a recent ischaemic stroke. The long-term (20-year) costs and effects of all alternatives were estimated with a decision analytic model combining the result of a clinical study and epidemiological data from Sweden. The structure of a cost-effectiveness analysis was used in this study. The short-term decision tree model analysed the screening procedure until the onset of anticoagulant treatment. The second part of the decision model followed a Markov design, simulating the patients' health states for 20 years. Continuous 24 h ECG recording was inferior to intermittent ECG in terms of cost-effectiveness, due to both lower sensitivity and higher costs. The base-case analysis compared intermittent ECG screening with no screening of patients with recent stroke. The implementation of the screening programme on 1000 patients resulted over a 20-year period in 11 avoided strokes and the gain of 29 life-years, or 23 quality-adjusted life years, and cost savings of €55 400. Screening of silent AF by intermittent ECG recordings in patients with a recent ischaemic stroke is a cost-effective use of health care resources saving costs and lives and improving the quality of life. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com.

    2. Prevalence of silent vertebral fractures detected by vertebral fracture assessment in young Portuguese men with hyperthyroidism.

      Science.gov (United States)

      Barbosa, Ana Paula; Rui Mascarenhas, Mário; Silva, Carlos Francisco; Távora, Isabel; Bicho, Manuel; do Carmo, Isabel; de Oliveira, António Gouveia

      2015-02-01

      Hyperthyroidism is a risk factor for reduced bone mineral density (BMD) and osteoporotic fractures. Vertebral fracture assessment (VFA) by dual-energy X-ray absorptiometry (DXA) is a radiological method of visualization of the spine, which enables patient comfort and reduced radiation exposure. This study was carried out to evaluate BMD and the prevalence of silent vertebral fractures in young men with hyperthyroidism. We conducted a cross-sectional study in a group of Portuguese men aged up to 50 years and matched in hyperthyroidism (n=24) and control (n=24) groups. A group of 48 Portuguese men aged up to 50 years was divided and matched in hyperthyroidism (n=24) and control (n=24) groups. BMD (g/cm(2)) at L1-L4, hip, radius 33%, and whole body as well as the total body masses (kg) were studied by DXA. VFA was used to detect fractures and those were classified by Genant's semiquantitative method. No patient had previously been treated for hyperthyroidism, osteoporosis, or low bone mass. Adequate statistical tests were used. The mean age, height, and total fat mass were similar in both groups (P≥0.05). The total lean body mass and the mean BMD at lumbar spine, hip, and whole body were significantly decreased in the hyperthyroidism group. In this group, there was also a trend for an increased prevalence of reduced BMD/osteoporosis and osteoporotic vertebral fractures. The results obtained using VFA technology (confirmed by X-ray) suggest that the BMD changes in young men with nontreated hyperthyroidism may lead to the development of osteoporosis and vertebral fractures. This supports the pertinence of using VFA in the routine of osteoporosis assessment to detect silent fractures precociously and consider early treatment. © 2015 European Society of Endocrinology.

    3. Prognostic significance of silent myocardial ischemia on a thallium stress test

      International Nuclear Information System (INIS)

      Heller, L.I.; Tresgallo, M.; Sciacca, R.R.; Blood, D.K.; Seldin, D.W.; Johnson, L.L.

      1990-01-01

      The clinical significance of silent ischemia is not fully known. The purpose of this study was to determine whether the presence or absence of angina during a thallium stress test positive for ischemia was independently predictive of an adverse outcome. Two hundred thirty-four consecutive patients with ischemia on a thallium stress test were identified. Ischemia was defined as the presence of defect(s) on the immediate postexercise scans not in the distribution of prior infarctions that redistributed on 4-hour scans. During the test 129 patients had angina, defined as characteristic neck, jaw, arm, back or chest discomfort, while the remaining 105 patients had no angina. Follow-up ranged from 2 to 8.2 years (mean 5.2 +/- 2.1) and was successfully obtained in 156 patients. Eighty-two of the 156 patients had angina (group A) and 74 had silent ischemia (group S). Group A patients were significantly older (62 +/- 8 vs 59 +/- 8 years, p less than 0.05). There was no significant difference between the 2 groups in terms of sex, history of prior infarction or presence of left main/3-vessel disease. A larger percentage of patients in group A were receiving beta blockers (60 vs 41%, p less than 0.05) and nitrates (52 vs 36%, 0.05 less than p less than 0.10). There was a large number of cardiac events (myocardial infarction, revascularization and death) in both groups (37 of 82 [45%] in group A; 28 of 72 [38%] in group S) but no statistically significant difference between the groups. Similarly, life-table analysis revealed no difference in mortality between the 2 groups

    4. Silent myocardial ischemia in patients with symptomatic intracranial atherosclerosis: associated factors.

      Science.gov (United States)

      Arenillas, Juan F; Candell-Riera, Jaume; Romero-Farina, Guillermo; Molina, Carlos A; Chacón, Pilar; Aguadé-Bruix, Santiago; Montaner, Joan; de León, Gustavo; Castell-Conesa, Joan; Alvarez-Sabín, José

      2005-06-01

      Optimization of coronary risk evaluation in stroke patients has been encouraged. The relationship between symptomatic intracranial atherosclerosis and occult coronary artery disease (CAD) has not been evaluated sufficiently. We aimed to investigate the prevalence of silent myocardial ischemia in patients with symptomatic intracranial atherosclerosis and to identify factors associated with its presence. From 186 first-ever transient ischemic attack or ischemic stroke patients with intracranial stenoses, 65 fulfilled selection criteria, including angiographic confirmation of a symptomatic atherosclerotic stenosis and absence of known CAD. All patients underwent a maximal-stress myocardial perfusion single-photon emission computed tomography (SPECT). Lipoprotein(a) [Lp(a)], C-reactive protein, and homocysteine (Hcy) levels were determined before SPECT. Stress-rest SPECT detected reversible myocardial perfusion defects in 34 (52%) patients. Vascular risk factors associated with a pathologic SPECT were hypercholesterolemia (P=0.045), presence of >2 risk factors (P=0.004) and high Lp(a) (P=0.023) and Hcy levels (P=0.018). Ninety percent of patients with high Lp(a) and Hcy levels had a positive SPECT. Existence of a stenosed intracranial internal carotid artery (ICA; odds ratio [OR], 7.22, 2.07 to 25.23; P=0.002) and location of the symptomatic stenosis in vertebrobasilar arteries (OR, 4.89, 1.19 to 20.12; P=0.027) were independently associated with silent myocardial ischemia after adjustment by age, sex, and risk factors. More than 50% of the patients with symptomatic intracranial atherosclerosis and not overt CAD show myocardial perfusion defects on stress-rest SPECT. Stenosed intracranial ICA, symptomatic vertebrobasilar stenosis and presence of high Lp(a) and Hcy levels may characterize the patients at a higher risk for occult CAD.

    5. Silent Majority, Violent Majority: The Counter-Revolution in 70s Cinema

      Directory of Open Access Journals (Sweden)

      Peter Andrew Novick

      2012-12-01

      Full Text Available «There is one question, Inspector Callahan: Why do they call you ‘Dirty Harry’?» Harry, it is explained, «…Hates everybody: Limeys, Micks, Hebes, Fat Degos, Niggers, Honkies, Chinks…especially Spics». Don Siegel’s Dirty Harry (1971, famously labeled «fascist» by prominent film critic Pauline Kael, nonetheless represented something new and unique—the “Silent Majority’s” entry into liberal New Hollywood, a veritable counter-reformation to the new social movements having sprung up in the late Sixties and early Seventies. Far from the traditional American Right, however, and distinctly un-Fascist (in as much as the term means more than a simple epithet, these films acted to unite traditional European philosophy and revolutionary thought with organic conservative American tendencies, resulting in hybrid films which challenged the new social movements, while working within the medium of liberal New American Cinema. The article will address three themes from the era: violence and race in the city, revenge against “liberated women”, and fear and loathing of homosexuality. In each instance, using primary evidence from films and critical reviews from the Seventies and the present era, in addition to American and European theorists, the article will show how the counter-revolution in Seventies cinema failed to expunge the “revolutionary spirit” of the era. Rather, the Silent Majority’s visions of visual violence and reactionary values became part and parcel of the new liberated culture of the “Me Decade,” forever bounding the conservative celluloid revolt to the new cinematic culture.

    6. Reducing calorie sales from supermarkets - 'silent' reformulation of retailer-brand food products.

      Science.gov (United States)

      Jensen, Jørgen Dejgård; Sommer, Iben

      2017-08-23

      Food product reformulation is seen as one among several tools to promote healthier eating. Reformulating the recipe for a processed food, e.g. reducing the fat, sugar or salt content of the foods, or increasing the content of whole-grains, can help the consumers to pursue a healthier life style. In this study, we evaluate the effects on calorie sales of a 'silent' reformulation strategy, where a retail chain's private-label brands are reformulated to a lower energy density without making specific claims on the product. Using an ecological study design, we analyse 52 weeks' sales data - enriched with data on products' energy density - from a Danish retail chain. Sales of eight product categories were studied. Within each of these categories, specific products had been reformulated during the 52 weeks data period. Using econometric methods, we decompose the changes in calorie turnover and sales value into direct and indirect effects of product reformulation. For all considered products, the direct effect of product reformulation was a reduction in the sale of calories from the respective product categories - between 0.5 and 8.2%. In several cases, the reformulation led to indirect substitution effects that were counterproductive with regard to reducing calorie turnover. However, except in two insignificant cases, these indirect substitution effects were dominated by the direct effect of the reformulation, leading to net reductions in calorie sales between -3.1 and 7.5%. For all considered product reformulations, the reformulation had either positive, zero or very moderate negative effects on the sales value of the product category to which the reformulated product belonged. Based on these findings, 'silent' reformulation of retailer's private brands towards lower energy density seems to contribute to lowering the calorie intake in the population (although to a moderate extent) with moderate losses in retailer's sales revenues.

    7. Lithium toxicity precipitated by thyrotoxicosis due to silent thyroiditis: cardiac arrest, quadriplegia, and coma.

      Science.gov (United States)

      Sato, Yoshinori; Taki, Katsumi; Honda, Yuki; Takahashi, Shoichiro; Yoshimura, Ashio

      2013-06-01

      Lithium is widely used to treat bipolar disorders. Lithium toxicity is generally caused by inappropriately high doses of lithium or impaired lithium excretion. Most lithium is eliminated via the kidneys and, since thyroid hormone increases tubular reabsorption of lithium, thyrotoxicosis could contribute to the development of lithium toxicity. We report a case of severe lithium toxicity that was apparently precipitated by the onset of thyrotoxicosis resulting from silent thyroiditis and dehydration. The patient was a 64-year-old woman who was admitted for muscle weakness in the lower extremities, diarrhea, and palpitations. She had bipolar disorder and was being treated with lithium carbonate, which she discontinued one week before admission. Her circulating lithium levels had been monitored yearly. Early in her admission she was dehydrated and had febrile episodes, paroxysmal atrial fibrillation, and muscle weakness. Initially, fluid therapy was started, but she lost consciousness and had a cardiac arrest for 2 minutes due to prolonged sinus arrest. Chest compression and manual artificial ventilation were performed, and body surface pacing was started. Serum lithium was markedly elevated to 3.81 mEq/L (therapeutic range, 0.4-1.0 mEq/L), and thyroid hormone levels were increased (free triiodothyronine, 8.12 pg/mL; free thyroxine, 4.45 ng/dL), while thyrotropin (TSH) was suppressed (quadriplegia and deep coma. She gradually recovered. On day 36, she was discharged without any neurological symptoms or thyrotoxicosis. A 64-year-old woman taking lithium for bipolar disorder developed lithium toxicity in the setting of what seemed likely to be a recent onset of thyrotoxicosis due to silent thyroiditis. Thyrotoxicosis may be a contributing cause of lithium toxicity, particularly if it is abrupt in onset and even with cessation of lithium therapy if renal function is compromised. Thyroid function should be assessed immediately in patients with suspected lithium

    8. Silent music reading: auditory imagery and visuotonal modality transfer in singers and non-singers.

      Science.gov (United States)

      Hoppe, Christian; Splittstößer, Christoph; Fliessbach, Klaus; Trautner, Peter; Elger, Christian E; Weber, Bernd

      2014-11-01

      In daily life, responses are often facilitated by anticipatory imagery of expected targets which are announced by associated stimuli from different sensory modalities. Silent music reading represents an intriguing case of visuotonal modality transfer in working memory as it induces highly defined auditory imagery on the basis of presented visuospatial information (i.e. musical notes). Using functional MRI and a delayed sequence matching-to-sample paradigm, we compared brain activations during retention intervals (10s) of visual (VV) or tonal (TT) unimodal maintenance versus visuospatial-to-tonal modality transfer (VT) tasks. Visual or tonal sequences were comprised of six elements, white squares or tones, which were low, middle, or high regarding vertical screen position or pitch, respectively (presentation duration: 1.5s). For the cross-modal condition (VT, session 3), the visuospatial elements from condition VV (session 1) were re-defined as low, middle or high "notes" indicating low, middle or high tones from condition TT (session 2), respectively, and subjects had to match tonal sequences (probe) to previously presented note sequences. Tasks alternately had low or high cognitive load. To evaluate possible effects of music reading expertise, 15 singers and 15 non-musicians were included. Scanner task performance was excellent in both groups. Despite identity of applied visuospatial stimuli, visuotonal modality transfer versus visual maintenance (VT>VV) induced "inhibition" of visual brain areas and activation of primary and higher auditory brain areas which exceeded auditory activation elicited by tonal stimulation (VT>TT). This transfer-related visual-to-auditory activation shift occurred in both groups but was more pronounced in experts. Frontoparietal areas were activated by higher cognitive load but not by modality transfer. The auditory brain showed a potential to anticipate expected auditory target stimuli on the basis of non-auditory information and

    9. Evaluation of blood loss after early or late release of ischemia in patients undergoing total knee replacement Avaliação da perda sanguínea após a liberação precoce ou tardia da isquemia em pacientes submetidos à artroplastia total do joelho

      Directory of Open Access Journals (Sweden)

      Marcos George de Souza Leão

      2013-04-01

      Full Text Available OBJECTIVE: compare blood loss in 40 patients underwent to unilateral total knee replacement with the release of ischemia before and after skin closure and compressive dressing. METHODS: in a prospective randomized study, in 40 patients underwent to total knee replacement, dividing then into two groups: group A in which the ischemia was released before skin closure, allowing bleeding control and group B where the ischemia was released after skin suture and pressure dressing. We compared the results of laboratory tests of serum hemoglobin before surgery and 48 hours postoperatively, the blood volume contained in vacuum suction drain and the transfusions that was necessary. RESULTS: As a result, the post operative serum hemoglobin levels had a mean decrease of 3.57 g/dL in group A and 4.24 g/dL in group B with an average of 0.67g/dL difference between them, statistically insignificant.The observed mean drainage, in the vacuum drain, were 705 mL in group A and 700 mL in group B. The 5ml difference between medians was considered statistically insignificant. The number of patients who received transfusions was four patients in both groups and all received two units of red blood cells. CONCLUSION: the post operative serum hemoglobin levels, as well as the need of blood transfusion, in the patient underwent to total knee replacement, where the ischemia was released before wound closure, has no statistical effect in comparison with patients where the sutures and bandages were done after the ischemia release. Level of Evidence IB - Individual randomized controlled trial with narrow confidence interval. OBJETIVO: Avaliar comparativamente a perda sanguínea em pacientes submetidos à artroplastia total do joelho, com liberação da isquemia antes e após suturas e curativo compressivo. MÉTODOS: Fez-se um estudo prospectivo randomizado em 40 pacientes submetidos à artroplastia total do joelho divididos em dois grupos. No primeiro grupo a isquemia foi

    10. Beneficial effects of hyperosmotic perfusion in the myocardium after ischemia/reperfusion injury in isolated rat hearts Efeitos benéficos da perfusão hiperosmótica no miocárdio após lesão isquemia/reperfusão em corações isolados de ratos

      Directory of Open Access Journals (Sweden)

      Yong Cao

      2013-03-01

      Full Text Available OBJECTIVE: A simple method to reduce the ischemia/reperfusion injury that can accompany cardiac surgery would have great clinical value. This study was to investigate the effect of hyperosmotic perfusion on ischemia/reperfusion injury in isolated perfused rat hearts. METHOD: Forty male Sprague-Dawley rats were randomly divided either to have their isolated hearts perfused with normal osmotic buffer or buffer made hyperosmotic by addition of glucose. Hearts were then subjected to 30 min ischemia followed by 30 min reperfusion. Coronary flow, time to ischemic arrest, reperfusion arrhythmia, and ventricular function were recorded. Creatine phosphokinase leakage into the coronary artery, and myocardial content and activity of superoxide dismutase and catalase were also examined. RESULTS: Rat hearts with hyperosmotic perfusion showed higher coronary flow, a prolonged time to ischemic arrest (10.60 vs. 5.63 min, POBJETIVO: Um método simples para reduzir a lesão de isquemia/reperfusão que pode acompanhar a cirurgia cardíaca teria grande valor clínico. O objetivo deste estudo foi investigar o efeito da perfusão hiperosmótica na isquemia/reperfusão em corações isolados de ratos perfundidos. MÉTODOS: Quarenta ratos machos Sprague-Dawley foram divididos aleatoriamente e tiveram os seus corações isolados perfundidos com tampão osmótico normal ou tampão hiperosmótico com a adição de glucose. Os corações foram então submetidos a 30 minutos de isquemia, seguida de 30 min de reperfusão. O fluxo coronariano, tempo de parada isquêmica, arritmia de reperfusão e da função ventricular foram registrados. Vazamento creatinofosfoquinase na artéria coronária, o miocárdio e atividade de superóxido dismutase e catalase foram também examinados. RESULTADOS: Crações de ratos com perfusão hiperosmótica apresentaram maior fluxo coronariano, tempo prolongado de parada isquêmica (10,60 vs. 5,63 min, P<0,005, menor pontuação de reperfus

    11. Ischemia and reperfusion in skin flaps: effects of mannitol and vitamin C in reducing necrosis area in a rat experimental model Isquemia e reperfusão de retalhos cutâneos: efeitos do manitol e vitamina C na redução de áreas de necrose em modelo experimental no rato

      Directory of Open Access Journals (Sweden)

      Winston Bonetti Yoshida

      2005-10-01

      Full Text Available PURPOSE: The aim of the present study was to develop an experimental model of ischemia-reperfusion injury in rat skin flap and to verify the effect of mannitol and vitamin C on reducing necrosis area. METHODS: A 6-x 3-cm groin skin flap was raised and submitted to 8 hours of ischemia by clamping the vascular pedicle and to 7 days of reperfusion. The animals were divided in four groups: S1 and S2 (10 animals each and C and T (14 animals each. In groups S1 and S2 skin flaps were not submitted to ischemia and animals received lactated Ringer's solution (S1 and antioxidant solution (S2 . In groups C and T, flaps were subjected to 8 hours of warm ischemia and animals received Lactated Ringer's solution (Group C and antioxidant solution immediately before reperfusion, (Group T. Flap survival was evaluated on the seventh day using a paper template technique and computer-assistant imaging analysis of necrotic and normal areas. RESULTS: Statistical analysis showed no area differences between groups C and T. CONCLUSION: The experimental model provided consistent necrotic area in control groups and drugs used were not effective in improving skin flap survival.OBJETIVO: Neste trabalho foi padronizado modelo experimental de isquemia e reperfusão em retalho cutâneo em ratos no qual estudou-se possibilidade de uma solução antioxidante, composta por Ringer lactato, vitamina C e manitol de reduzir a área de necrose. MÉTODOS: O modelo consistiu de levantamento de retalho cutâneo axial de 6,0 x 3,0cm, submetido à isquemia de 8 horas e reperfusão de 7 dias. Os animais foram divididos em quatro grupos: grupos S1, S2 (10 animais cada, C e T (14 animais cada. Nos grupos S1 e S2 todos os procedimentos dos demais grupos foram efetuados, exceto a isquemia e reperfusão: S1 recebeu apenas Ringer lactato e S2 a solução antioxidante. Os grupos C e T foram submetidos à isquemia. O grupo C recebeu somente Ringer lactato e o grupo T a solução antioxidante. No 7

    12. Hematological and hemostaseological alterations after warm and cold limb ischemia-reperfusion in a canine model Alterações hematológicas e hemostaseológicas após isquemia-reperfusão morna e fria de membro inferior em modelo canino

      Directory of Open Access Journals (Sweden)

      Miklos Szokoly

      2009-10-01

      Full Text Available PURPOSE: Acute ischemia-reperfusion (I/R of extremities means serious challenge in the clinical practice. Furthermore, the issue of preventive cooling is still controversial. In this canine model we investigated whether limb I/R -with or without cooling- has an influence on hematological and hemostaseological factors. METHODS: Femoral vessels were exposed and clamped for 3 hours. After release the clamps, 4-hour reperfusion was secured. The same procedures with cooling using ice bags, as well as warm and cold sham-operations were performed. Before operations, from the excluded limb by the end of ischemia, during the reperfusion, and for 5 postoperative days afterwards blood samples were collected for testing hematological and blood coagulation parameters. RESULTS: After I/R activated partial thromboplastin time was elongated on 2nd-4th postoperative days. The highest values were on the 2nd day in cold I/R group, accompanied by increased prothrombin time values. The hematological parameters and fibrinogen level showed non-specific changes. In excluded ischemic limb the blood composition showed controversial data. Cold ischemia induced larger alterations, however platelet count, hematocrit changed more expressly in warm ischemia. CONCLUSION: These results indicate the risk of coagulopathy following limb I/R on early post-eventually days, which risk is higher in the case of cold I/R.OBJETIVO: Isquemia-Reperfusão aguda (I/R de extremidades representa um desafio sério na prática clínica. Além disso, o tema de prevenção pelo resfriamento é ainda controverso. Nesse modelo canino, investigou-se se I/R de membros -com ou sem resfriamento- tem influência nos fatores hematológicos e hemostaseológicos. MÉTODOS: Os vasos femorais foram expostos e clampeados por 3 horas. Após liberação dos clampes, foi realizada a reperfusão por 4-horas. Os mesmos procedimentos com e sem resfriamento usando bolsas de gelo, assim como operações simuladas com

    13. Oxidative stress gene expression profile in inbred mouse after ischemia/reperfusion small bowel injury Perfil da expressão gênica do estresse oxidativo em camundongos isogênicos após lesão de isquemia e reperfusão intestinal

      Directory of Open Access Journals (Sweden)

      Paulo Roberto Bertoletto

      2012-11-01

      Full Text Available PURPOSE: To determine the profile of gene expressions associated with oxidative stress and thereby contribute to establish parameters about the role of enzyme clusters related to the ischemia/reperfusion intestinal injury. METHODS: Twelve male inbred mice (C57BL/6 were randomly assigned: Control Group (CG submitted to anesthesia, laparotomy and observed by 120min; Ischemia/reperfusion Group (IRG submitted to anesthesia, laparotomy, 60min of small bowel ischemia and 60min of reperfusion. A pool of six samples was submitted to the qPCR-RT protocol (six clusters for mouse oxidative stress and antioxidant defense pathways. RESULTS: On the 84 genes investigated, 64 (76.2% had statistic significant expression and 20 (23.8% showed no statistical difference to the control group. From these 64 significantly expressed genes, 60 (93.7% were up-regulated and 04 (6.3% were down-regulated. From the group with no statistical significantly expression, 12 genes were up-regulated and 8 genes were down-regulated. Surprisingly, 37 (44.04% showed a higher than threefold up-regulation and then arbitrarily the values was considered as a very significant. Thus, 37 genes (44.04% were expressed very significantly up-regulated. The remained 47 (55.9% genes were up-regulated less than three folds (35 genes - 41.6% or down-regulated less than three folds (12 genes - 14.3%. CONCLUSION: The intestinal ischemia and reperfusion promote a global hyper-expression profile of six different clusters genes related to antioxidant defense and oxidative stress.OBJETIVO: Determinar o perfil de expressão dos genes associados com estresse oxidativo e contribuir para estabelecer parâmetros sobre o papel das familias de enzimas relacionadas com a lesão de isquemia / reperfusão intestinal. MÉTODOS: Doze camundongos machos isogênicos (C57BL/6 foram distribuídos aleatoriamente: Grupo Controle (CG submetido à laparotomia anestesia, e observado por 120min; Grupo isquemia/reperfusão (IRG

    14. preescolares desnutridos con madres con obesidad y sin obesidad

      Directory of Open Access Journals (Sweden)

      Viridiana Vanessa Conzuelo-González

      2009-01-01

      Full Text Available El primer objetivo fue conocer cuántos menores de cinco años con diferentes grados de desnutrición tienen una madre con sobrepeso/obesidad/ en una comunidad indígena que vive en extrema pobreza y bajo condiciones de migración masculina internacional. El segundo fue comparar tres variables socionutricionales (ingreso familiar, educación de la madre y adecuación nutrimental de la dieta diaria entre estos hogares y los hogares con desnutrición infantil y madres sin obesidad. Se realizó un estudio transversal (2006-2007, en la comunidad mazahua de San Francisco Tepeolulco, Municipio de Temascalcingo; que incluyó a 85 hogares integrados por preescolares con desnutrición inscritos al programa Oportunidades. Se determinó el estado nutrición de los preescolares con indicadores antropométricos y se obtuvo el IMC de las madres de estos infantes. Se aplicó una encuesta socionutricional, incluida el recordatorio de 24 horas, y complementado con la observación participante (cualitativa. Se encontró que 83% de las madres mazahuas presentaron sobrepeso u obesidad. El estado de nutrición de los preescolares con madres con obesidad presentó un porcentaje mayor de desnutrición (76%. En la variable género, se encontró que 54% de los niños con madres con obesidad tenía baja talla. Al relacionar el nivel educativo de la madre, esta variable resultó ser estadísticamente significativa (p=0.015, donde el analfabetismo está más relacionado con la desnutrición infantil que tienen madres de bajo y/o peso normal. La elevada prevalencia de hogares conformados con preescolares con desnutrición y madres con obesidad, es un síntoma más de la pobreza en zonas indígenas en México, con bajo índice de desarrollo humano.

    15. Tratamento da Isquemia Mesentérica Crônica através da Angioplastia do Tronco Celíaco: Série de Casos / Treatment of Chronic Mesenteric Ischemia through Celiac Trunk Angioplasty: Case Series

      Directory of Open Access Journals (Sweden)

      Dante Togeiro Bastos Filgueiras

      2016-09-01

      Full Text Available Introdução: A estenose aterosclerótica das artérias viscerais pode ser responsável pela manifestação da Isquemia Mesentérica Crônica (IMC. Apesar de o Tronco Celíaco (TC ser o vaso mais frequentemente acometido, o tratamento cirúrgico é cada vez menos utilizado. O tratamento endovascular, apesar de possuir perviedade inferior a longo prazo, tornou-se o método de escolha devido à fácil execução e baixo índice de complicações. Relato de Casos: Descreve-se quatro casos de revascularização endovascular do TC com implante de stent em pacientes com sintomas de IMC. A avaliação diagnóstica foi realizada através de angioTC helicoidal. Três casos foram realizados por meio do acesso femoral. O sucesso técnico foi de 100%, entretanto um caso necessitou de conversão para acesso braquial. Houve um caso de migração proximal do stent. Todos os pacientes apresentaram melhora subjetiva dos sintomas. Conclusão: Os métodos de imagem são fundamentais para o diagnóstico e planejamento terapêutico. O tratamento endovascular para as lesões estenóticas do TC é o método de escolha na atualidade, devido aos baixos índices de complicações e aceitável taxa de perviedade primária no curto e médio prazo. A aplicação objetiva de questionários de qualidade de vida, entretanto, é necessária para confirmar a eficácia clínica do tratamento. Introduction: Atherosclerotic stenosis of visceral arteries may be responsible for the manifestation of Chronic Mesenteric Ischemia (CMI. Although the Celiac Trunk (CT is the most commonly affected vessel, surgical treatment has been less used. Endovascular treatment, despite lower long-term patency, has become the method of choice due to feasibility and low complication rates. Cases Report: Four cases of endovascular revascularization of CT with stenting are described in patients with suggestive symptoms of CMI. The diagnostic evaluation was performed using multislice CT angiography. Three

    16. autorregulado con estudiantes universitarios

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      Jairo Andrés Montes

      2005-01-01

      Full Text Available El propósito del presente estudio es describir la forma en la que se presentan los procesos de aprendizaje autorregulado con un grupo de estudiantes (22 estudiantes de tercer semestre de Psicología de la PUJ, Cali, en el evento de preparación para la presentación un examen. Asimismo se describen las correlaciones que ocurren entre las distintas fases de dicho proceso de autorregulación del aprendizaje. Para conseguir los objetivos propuestos se ha hecho uso de una observación de desempeño en tiempo real, es decir, de la observación durante una sesión de preparación de examen de los estudiantes, en la cual se emplearon protocolos verbales para dar cuenta de lo que «pasaba por su mente» mientras estudiaban. Una entrevista semi-estructurada y una prueba objetiva. Los resultados fueron analizados a la luz del modelo mixto de procesamiento de información y constructivismo abordado por Winne(1998. Como resultado se encontró una relación significativa entre los niveles de desempeño en el proceso de ARR y el resultado del examen. Igualmente se encontraron bajos niveles de regulación en una parte importante de la muestra y un desfase significativo entre conocimiento declarativo de ARR y desempeño en el mismo

    17. Noncardiac findings on cardiac CT part I: Pros and cons.

      LENUS (Irish Health Repository)

      Killeen, Ronan P

      2012-02-01

      Cardiac computed tomography (CT) has evolved into an effective imaging technique for the evaluation of coronary artery disease in selected patients. Two distinct advantages over other noninvasive imaging modalities include its ability to evaluate directly the coronary arteries and to provide an opportunity to evaluate extracardiac structures, such as the lungs and mediastinum. Some centers reconstruct a small field of view (FOV) cropped around the heart, but a full FOV (from skin to skin in the irradiated area) is obtainable in the raw data of every scan so that clinically relevant noncardiac findings are identifiable. Debate in the scientific community has centered on the necessity for this large FOV evaluation. A review of noncardiac structures provides the opportunity to make alternative diagnoses that may account for the patient\\'s presentation or to detect important but clinically silent problems such as lung cancer. Critics argue that the yield of biopsy-proven cancers is low and that the follow-up of incidental noncardiac findings is expensive, resulting in increased radiation exposure and possibly unnecessary further testing. In this two-part review we outline the issues surrounding the concept of the noncardiac read looking for noncardiac findings on cardiac CT. Part I focuses on the pros and cons of the practice of identifying noncardiac findings on cardiac CT.

    18. Puentes con vigas pretensadas

      Directory of Open Access Journals (Sweden)

      Editorial, Equipo

      1965-07-01

      Full Text Available This paper describes one of the three bridges which Hidrocivil, S. A., has built in Catalonia (northern Spain, over the river Ripoll. The other two bridges are very similar to this one, both in construction and design, and show only minor adjustments to the local topography. The contracting firm proposed several alterations in the prefabrication and constructional procedure, in relation to the initial project, and these changes were accepted. The main feature of these projects is the use of prestressed beams, built at the workshop in sections, and joined together by means of sixty 7 mm cables in each beam. As the shear forces are more acute at the joints, the end of each section has a kind of diaphragm, to provide a large contact area, and hence greater surface to transmit the shear forces. The methods of construction are also of interest. Briefly, they involve building the bridge piles, and use these to support a provisional structure with transversal movement. This provisional structure, in turn, served as platform for two bridge cranes, which lifted the girders to their final location. After the first span was completed, the deck was concreted and the auxiliary structure pushed forward to the next span, to repeat the same operations. This arrangement saved the use of provisional framework.En este trabajo se describe uno de los tres puentes que Hidrocivil, S. A., ha construido.—previo concurso— en la región catalana; concretamente, el que salva el río Ripoll. Los otros dos no han sido objeto de descripción general por ser muy similares, en lo que a ejecución y concepción se refiere, con la única variante que presentan las características topográficas locales. La empresa propuso ciertas variantes— que fueron aceptadas— en la prefabricación y métodos de construcción. El interés de estas obras se centra en el empleo de vigas pretensadas, prefabricadas en taller por trozos, y solidarizados en el mismo mediante las operaciones

    19. Violencia con el anciano

      Directory of Open Access Journals (Sweden)

      Rita Campillo Motilva

      2002-08-01

      Full Text Available La violencia doméstica es tan antigua como la humanidad misma y se reconocen la violencia infantil, contra la mujer y al anciano, fundamentalmente; siendo este último grupo una población en ascenso por las mayores expectativas de vida de los últimos años. Como resultado de ello, el número de casos de abuso en el anciano se incrementará y el impacto de este abuso sobre la salud debe ser considerado de forma adecuada. La gama de maltratos es variadísima e incluye el abuso físico, emocional, financiero, sexual, por negligencia, negación a brindarle ayuda y otras formas más. Los ancianos con deterioro cognitivo son los más vulnerables. El médico en la atención primaria de salud es un pilar importante en la prevención y educación de este problema.Domestic violence is as old as humanity itself. Child, women and elderly abuse are mainly recognized. The elderly group is increasing due to the higher life expectancy experimented during the last years. As a result, the number of battered elderly will grow and the impact of this abuse on health should be adequately considered. The range of abuse is very wide and it includes physical, emotional, financial and sexual abuse, negligence, rejection to give assistance and others. The elderly with cognitive deterioration are the most vulnerable. The physician at the primary health care level is an important milestone in the prevention and education of this problem.

    20. "Silent" Sleep Apnea in Dentofacial Deformities and Prevalence of Daytime Sleepiness After Orthognathic and Intranasal Surgery.

      Science.gov (United States)

      Posnick, Jeffrey C; Adachie, Anayo; Singh, Neeru; Choi, Elbert

      2018-04-01

      The purposes of this study were to determine the occurrence of undiagnosed "silent" obstructive sleep apnea (OSA) in dentofacial deformity (DFD) patients at initial surgical presentation and to report on the level of daytime sleepiness in DFD patients with OSA and chronic obstructive nasal breathing (CONB) after undergoing bimaxillary, chin, and intranasal surgery. A retrospective cohort study of patients with a bimaxillary DFD and CONB was implemented. Patients were divided into those with no OSA (group I) and those with OSA (group II). Group II was further subdivided into patients referred with polysomnogram (PSG)-confirmed OSA (group IIa) and those with a diagnosis of OSA only after surgical consultation, airway evaluation, and a positive PSG (group IIb). Group II patients were analyzed at a minimum of 1 year after surgery (range, 1 to 10 years) for daytime sleepiness with the Epworth Sleepiness Scale. Patients with postoperative excessive daytime sleepiness were assessed for risk factors and continued need for OSA treatment. Patients in group II were studied to determine which DFD patterns were most associated with OSA. We compared the prevalence of OSA between our study population and the general population. Two hundred sixty-two patients met the inclusion criteria. Of these, 23% (60 of 262) had PSG-confirmed OSA (group II). This rate was much higher than that found in the general population. Of the patients, 7% (19 of 262) were known to have OSA at initial surgical consultation (group IIa). An additional 16% (41 of 262) were later confirmed by PSG to have OSA (group IIb). Patients with primary mandibular deficiency and short face DFDs were most likely to have OSA (P surgery. A significant association was found between group II patients with postoperative excessive daytime sleepiness ("sleepy" or "very sleepy") and a preoperative body mass index category of overweight (P = .026). Our study found silent OSA to be frequent in the DFD population. The

    1. "So oft to the movies they've been": British fan writing and female audiences in the silent cinema

      Directory of Open Access Journals (Sweden)

      Lisa Rose Stead

      2011-03-01

      Full Text Available This article aims to address the ways in which working-class and lower-middle-class British women used silent-era fan magazines as a space for articulating their role within the development of a female film culture. The article focuses on letter pages that formed a key site for female contribution to British fan magazines across the silent era. In contributing to these pages, women found a space to debate and discuss the appeal and significance of particular female representations within film culture. Using detailed archival research tracing the content of a specific magazine, Picturegoer, across a 15-year period (1913–28, the article will show the dominance of particular types of female representation in both fan and "official" magazine discourses, analyzing the ways in which British women used these images to work through national tensions regarding modern femininity and traditional ideas of female propriety and restraint.

    2. Alkaline electrolyzer and V2G system DIgSILENT models for demand response analysis in future distribution networks

      DEFF Research Database (Denmark)

      Diaz de Cerio Mendaza, Iker; Bak-Jensen, Birgitte; Chen, Zhe

      2013-01-01

      Grid instabilities originated by unsteady generation, characteristic consequence of some renewable energy resources such as wind and solar power, claims for new power balance solutions in largely penetrated systems. Denmark's solid investment in these energy sources has awaked a need of rethinking...... about the future control and operation of the power system. A widespread idea to face these challenges is to have a flexible demand easily adjustable to the system variations. Electrothermal loads, electric vehicles and hydrogen generation are among the most mentioned technologies capable to respond......, under certain strategies, to these variations. This paper presents two DIgSILENT PowerFactory models: an alkaline electrolyzer and a vehicle to the grid system. The models were performed using DIgSILENT Simulation Language, aiming to be used for long-term distribution systems simulations. Two voltage...

    3. Radio jets and gamma-ray emission in radio-silent narrow-line Seyfert 1 galaxies

      Science.gov (United States)

      Lähteenmäki, A.; Järvelä, E.; Ramakrishnan, V.; Tornikoski, M.; Tammi, J.; Vera, R. J. C.; Chamani, W.

      2018-06-01

      We have detected six narrow-line Seyfert 1 (NLS1) galaxies at 37 GHz that were previously classified as radio silent and two that were classified as radio quiet. These detections reveal the presumption that NLS1 galaxies labelled radio quiet or radio silent and hosted by spiral galaxies are unable to launch jets to be incorrect. The detections are a plausible indicator of the presence of a powerful, most likely relativistic jet because this intensity of emission at 37 GHz cannot be explained by, for example, radiation from supernova remnants. Additionally, one of the detected NLS1 galaxies is a newly discovered source of gamma rays and three others are candidates for future detections. 37 GHz data are only available in electronic form at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/614/L1

    4. Female’s Silent Resistance against Hegemony in The Scarlet Letter, Bekisar Merah, and Belantik: A Comparative Analysis

      Directory of Open Access Journals (Sweden)

      RB. Edi Pramono

      2013-08-01

      Full Text Available Social patriarchy is a gender-biased hegemonic value that is structured for the benefits of men but unfortunately disadvantages women. Lasiyah, the protagonist of Bekisar Merah and Belantik, and Hester Prynne, the protagonist of The Scarlet Letter, experienced those hegemonic values that were oppressive, from their patriarchal societies i.e. Java and Puritans. By using the theories of both Hegemony and Comparative Literature, this discussion reveals the two protagonists’ similar silent resistance against the hegemonic values in that this brought them to become new persons with new personality and identity. They were similarly reborn. Both women had comparable factors driving them to conduct silent resistance: pride, dignity, and love. Woman, who is in general considered weak and powerless, is in fact strong and powerful.

    5. Promises of silent salesman to the FMCG industry: an investigation using linear discriminant analysis approach

      Directory of Open Access Journals (Sweden)

      Shekhar Suraj Kushe

      2015-12-01

      Full Text Available Packaging which is often called as the ‘silent salesman’ is an important component of marketing. Today the importance of packaging has risen to such an extent that product packaging is rightly called as the fifth ‘P’ of marketing mix. FMCG are products which are utilized by large number of people. The present study examined the discriminating power of five selected FMCG packaging variables namely ‘picture’, ‘colour’, ‘size’, ‘shape’ and ‘material’ amidst those who purchased FMCG based on these packaging variables and for those who purchased FMCG not based on these packaging variables. Descriptive research was carried out in the study. Respondents (students were asked to rate four packaging variable on a five point Likert’s scale. Discriminant analysis showed that only two variables namely ‘Colour’ (.706 and ‘Shape’ (–.527 were good predictors. Variables ‘Picture’, ‘size’ and ‘material’ were considered as poor predictors as far as the student communities were considered. The cross validated classification showed that out of the 240 samples drawn, 91.8% of the cases were correctly classified.

    6. Exercise-induced silent myocardial ischemia: Evaluation by thallium-201 emission computed tomography

      International Nuclear Information System (INIS)

      Kurata, C.; Sakata, K.; Taguchi, T.; Kobayashi, A.; Yamazaki, N.

      1990-01-01

      Factors associated with silent myocardial ischemia (SMI) during exercise testing were studied by means of thallium-201 emission computed tomography (ECT) in 471 patients. Coronary angiography was done in 290, of whom 167 were found to have significant coronary artery disease (CAD). Exercise-induced ischemia and its severity were defined with ECT. During exercise 108 (62%) of 173 patients with ischemia and 57 (50%) of 115 with ischemia and angiographically documented CAD had no chest pain. One third of the patients showed an inconsistency between scintigraphic ischemia and ischemia ST depression. Age, sex, prior myocardial infarction, and diabetes mellitus were not related to SMI. Patients with SMI had less severe ischemia despite a higher peak double product compared to those with painful ischemia. Among 91 with prior myocardial infarction and exercise-induced ischemia, 51 with periinfarction ischemia had a higher frequency of SMI than did 14 with ischemia remote from the prior infarct zone despite similarities in the severity of ischemia. In conclusion, factors localized within ischemic myocardium such as less severe ischemia or adjacency to a prior infarct made SMI more prevalent

    7. Synthetic mimetics of the endogenous gastrointestinal nanomineral: Silent constructs that trap macromolecules for intracellular delivery.

      Science.gov (United States)

      Pele, Laetitia C; Haas, Carolin T; Hewitt, Rachel E; Robertson, Jack; Skepper, Jeremy; Brown, Andy; Hernandez-Garrido, Juan Carlos; Midgley, Paul A; Faria, Nuno; Chappell, Helen; Powell, Jonathan J

      2017-02-01

      Amorphous magnesium-substituted calcium phosphate (AMCP) nanoparticles (75-150nm) form constitutively in large numbers in the mammalian gut. Collective evidence indicates that they trap and deliver luminal macromolecules to mucosal antigen presenting cells (APCs) and facilitate gut immune homeostasis. Here, we report on a synthetic mimetic of the endogenous AMCP and show that it has marked capacity to trap macromolecules during formation. Macromolecular capture into AMCP involved incorporation as shown by STEM tomography of the synthetic AMCP particle with 5nm ultra-fine iron (III) oxohydroxide. In vitro, organic cargo-loaded synthetic AMCP was taken up by APCs and tracked to lysosomal compartments. The AMCP itself did not regulate any gene, or modify any gene regulation by its cargo, based upon whole genome transcriptomic analyses. We conclude that synthetic AMCP can efficiently trap macromolecules and deliver them to APCs in a silent fashion, and may thus represent a new platform for antigen delivery. Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.

    8. Current perspectives on the etiology and manifestation of the "silent" component of the Female Athlete Triad

      Directory of Open Access Journals (Sweden)

      Mallinson RJ

      2014-05-01

      Full Text Available Rebecca J Mallinson, Mary Jane De SouzaDepartment of Kinesiology, Women's Health and Exercise Laboratory in Noll Laboratory, Pennsylvania State University, University Park, PA, USAAbstract: The Female Athlete Triad (Triad represents a syndrome of three interrelated conditions that originate from chronically inadequate energy intake to compensate for energy expenditure; this environment results in insufficient stored energy to maintain physiological processes, a condition known as low energy availability. The physiological adaptations associated with low energy availability, in turn, contribute to menstrual cycle disturbances. The downstream effects of both low energy availability and suppressed estrogen concentrations synergistically impair bone health, leading to low bone mineral density, compromised bone structure and microarchitecture, and ultimately, a decrease in bone strength. Unlike the other components of the Triad, poor bone health often does not have overt symptoms, and therefore develops silently, unbeknownst to the athlete. Compromised bone health among female athletes increases the risk of fracture throughout the lifespan, highlighting the long-term health consequences of the Triad. The purpose of this review is to examine the current state of Triad research related to the third component of the Triad, ie, poor bone health, in an effort to summarize what we know, what we are learning, and what remains unknown.Keywords: female athlete Triad, bone health, treatment

    9. Importance of 201Tl scintigraphy during exercise for diagnosis of silent myocardial ischemia

      International Nuclear Information System (INIS)

      Kasalicky, J.; Kidery, J.; Svacinka, J.; Vanko, J.; Brunova, J.; Bartos, V.

      1990-01-01

      Using thallium scintigraphy during exercise (TSE), suspect silent myocardial ischemia (SIM) was diagnosed in subjects without angina pectoris. 21 active pilots with suspect SIM were examined after previous exercise ECG as well as 33 patients with diabetes type I and II. In six pilots (28.6%) TSE showed accumulation defects suggesting ischemic disorders of the large coronary arteries. Five pilots showed obvious depressions of the ST segment in ECG during submaximal exercise TSE. In another group of five pilots small depressions of the ST segment were associated with normal TSE. Twelve diabetic patients (36.4%) had minor accumulation defects on TSE. Only two showed a ST depression under 2 mm in ECG during TSE. Based on data in the literature suggesting higher sensitivity and specificity of exercise thallium scintigraphy as compared with exercise ECG and the possibility of a false positive diagnosis of SIM from exercise ECG alone, it is recommended to also use TSE. A more detailed diagnosis of SIM is essential not only with regard to the assessment of work capacity but also for a long-term follow-up of patients with SIM for assessment of its incidence, impact and prognosis in the population. (author). 4 figs., 4 tabs., 25 refs

    10. Screaming Body and Silent Healthcare Providers: A Case Study with a Childhood Sexual Abuse Survivor

      Directory of Open Access Journals (Sweden)

      Sigrun Sigurdardottir

      2018-01-01

      Full Text Available Stressful early life experiences cause immune dysregulation across the lifespan. Despite the fact that studies have identified childhood sexual abuse (CSA survivors as a particularly vulnerable group, only a few attempts have been made to study their lived-experience of the physical health consequences of CSA. The aim of this study was to explore a female CSA survivor’s lived-experience of the physical health consequences of CSA and how she experienced the reactions of healthcare providers. Seven interviews were conducted with this 40-year-old woman, Anne, using a phenomenological research approach. Anne was still a young child (two to three years old when her father started to rape her. Since her childhood, she has experienced complex and widespread physical health consequences such as repeated vaginal and abdominal infections, widespread and chronic pain, sleeping problems, digestive problems, chronic back problems, fibromyalgia, musculoskeletal problems, repeated urinary tract infections, cervical dysplasia, inflammation of the Fallopian tubes, menorrhagia, endometrial hyperplasia, chlamydia, ovarian cysts, ectopic pregnancies, uterus problems, severe adhesions, and ovarian cancer. Anne disclosed her CSA experience to several healthcare providers but they were silent and failed to provide trauma-informed care. Anne’s situation, albeit unique, might reflect similar problems in other female CSA survivors.

    11. Complex behavior in a network with time-dependent connections and silent nodes

      International Nuclear Information System (INIS)

      Marro, J; Torres, J J; Cortes, J M

      2008-01-01

      We studied, both analytically and numerically, excitable networks in which connections are time-dependent and some of the nodes remain silent at each time step, and we show that these two features may induce intriguing functional complexity. More specifically, we consider (a) a heterogeneous distribution of connection weights such that, depending on the current degree of order, some connections are reinforced/weakened with strength Φ on short timescales, and (b) that only a fraction ρ of nodes are simultaneously active. The resulting dynamics has attractors which, for a range of Φ values and ρ exceeding a threshold, become unstable, the instability depending critically on the value of ρ. We observe that (i) the activity describes a trajectory in which the close neighborhood of some of the attractors is constantly visited, (ii) the number of attractors visited increases with ρ, and (iii) the trajectory may change from regular to chaotic and vice versa as ρ is, even slightly modified. Furthermore, (iv) time series show a power-law spectra under conditions in which the attractors' space tends to be most efficiently explored. We argue on the possible qualitative relevance of this phenomenology to networks in several natural contexts

    12. Silent information regulator T1 in aqueous humor of patients with cataract

      Directory of Open Access Journals (Sweden)

      Kondo A

      2016-02-01

      Full Text Available Aki Kondo,1 Mari Goto,2 Tatsuya Mimura,1 Masao Matsubara1 1Department of Ophthalmology, Tokyo Women’s Medical University Medical Center East, 2Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan Purpose: Silent information regulator T1 (SIRT1, a member of the sirtuin family, has a preventive role in various ocular diseases. We evaluated the relations between the aqueous humor level of SIRT1 and age, sex, systemic diseases, the severity of lens opacity, and other factors. Setting: This study was conducted at a university teaching hospital in Tokyo, Japan. Design: This study was designed based on the consecutive case series. Methods: Aqueous humor samples were obtained from 29 eyes of the 21 consecutive patients undergoing surgery for age-related cataract (ARC. SIRT1 levels were determined by enzyme-linked immunosorbent assay. Results: Aqueous humor levels of SIRT1 showed a positive correlation with visual acuity (logarithm of the minimum angle of resolution and with the severity of nuclear cataract (r=0.32 and 0.30, respectively, P<0.05. However, only visual acuity was correlated with SIRT1 according to the stepwise multiple regression analysis (P<0.05. Conclusion: These findings suggest that SIRT1 may have an effect on the formation of ARC, acting as a defensive factor against ARC. Keywords: SIRT1, sirtuin, cataract surgery, oxidative stress, resveratrol, ocular aging

    13. Silent left ventricular dysfunction during routine activity after thrombolytic therapy for acute myocardial infarction

      International Nuclear Information System (INIS)

      Kayden, D.S.; Wackers, F.J.; Zaret, B.L.

      1990-01-01

      To investigate prospectively the occurrence and significance of postinfarction transient left ventricular dysfunction, 33 ambulatory patients who underwent thrombolytic therapy after myocardial infarction were monitored continuously for 187 +/- 56 min during normal activity with a radionuclide left ventricular function detector at the time of hospital discharge. Twelve patients demonstrated 19 episodes of transient left ventricular dysfunction (greater than 0.05 decrease in ejection fraction, lasting greater than or equal to 1 min), with no change in heart rate. Only two episodes in one patient were associated with chest pain and electrocardiographic changes. The baseline ejection fraction was 0.52 +/- 0.12 in patients with transient left ventricular dysfunction and 0.51 +/- 0.13 in patients without dysfunction (p = NS). At follow-up study (19.2 +/- 5.4 months), cardiac events (unstable angina, myocardial infarction or death) occurred in 8 of 12 patients with but in only 3 of 21 patients without transient left ventricular dysfunction (p less than 0.01). During submaximal supine bicycle exercise, only two patients demonstrated a decrease in ejection fraction greater than or equal to 0.05 at peak exercise; neither had a subsequent cardiac event. These data suggest that transient episodes of silent left ventricular dysfunction at hospital discharge in patients treated with thrombolysis after myocardial infarction are common and associated with a poor outcome. Continuous left ventricular function monitoring during normal activity may provide prognostic information not available from submaximal exercise test results

    14. Culturally sensitive strategies designed to target the silent epidemic of hepatitis B in a Filipino community.

      Science.gov (United States)

      Marineau, Michelle; Tice, Alan D; Taylor-Garcia, David; Akinaka, Kenneth T; Lusk, Heather; Ona, Fernando

      2007-06-01

      Hepatitis B is frequent in the Philippines. A high rate of immigration to the United States has brought many Filipinos with infections who are asymptomatic yet will go on to develop liver cancer and cirrhosis unless diagnose and evaluated. Interventions are necessary to educate this ethnic community, identify those infected, and offer therapy. In an effort to reach this high risk population in Hawai'i an intervention program was designed to address the silent epidemic of hepatitis. Ethnic barriers were crossed through involvement of trusted, key stakeholders and individuals within the Filipino health care and church communities, along with groups that had joint missions to address viral hepatitis. After extensive planning and meetings with faith-based organizations and health care providers in the Filipino community, it was decided to hold a community health fair in the Filipino community to provide culturally appropriate health information and services. More than 500 individuals attended the health fair; 167 participated in a survey and were tested for hepatitis B. Significant knowledge gaps were found in relation to risk factors, prevention strategies, and transmission. Five individuals tested positive; all were immigrants and did not know of their disease. The objective to educate people and test them for hepatitis was successful through utilizing ethnic community leaders, religious organizations, health care professionals, and a collaborative health fair.

    15. Temporal integration of sequential auditory events: silent period in sound pattern activates human planum temporale.

      Science.gov (United States)

      Mustovic, Henrietta; Scheffler, Klaus; Di Salle, Francesco; Esposito, Fabrizio; Neuhoff, John G; Hennig, Jürgen; Seifritz, Erich

      2003-09-01

      Temporal integration is a fundamental process that the brain carries out to construct coherent percepts from serial sensory events. This process critically depends on the formation of memory traces reconciling past with present events and is particularly important in the auditory domain where sensory information is received both serially and in parallel. It has been suggested that buffers for transient auditory memory traces reside in the auditory cortex. However, previous studies investigating "echoic memory" did not distinguish between brain response to novel auditory stimulus characteristics on the level of basic sound processing and a higher level involving matching of present with stored information. Here we used functional magnetic resonance imaging in combination with a regular pattern of sounds repeated every 100 ms and deviant interspersed stimuli of 100-ms duration, which were either brief presentations of louder sounds or brief periods of silence, to probe the formation of auditory memory traces. To avoid interaction with scanner noise, the auditory stimulation sequence was implemented into the image acquisition scheme. Compared to increased loudness events, silent periods produced specific neural activation in the right planum temporale and temporoparietal junction. Our findings suggest that this area posterior to the auditory cortex plays a critical role in integrating sequential auditory events and is involved in the formation of short-term auditory memory traces. This function of the planum temporale appears to be fundamental in the segregation of simultaneous sound sources.

    16. Comorbidity of internal derangement of the temporomandibular joint and silent dysfunction of the cervical spine.

      Science.gov (United States)

      Stiesch-Scholz, M; Fink, M; Tschernitschek, H

      2003-04-01

      The aim of this evaluation was to examine correlations between internal derangement of the temporomandibular joint (TMJ) and cervical spine disorder (CSD). A prospective controlled clinical study was carried out. Thirty patients with signs and symptoms of internal derangement but without any subjective neck problems and 30 age- and gender-matched control subjects without signs and symptoms of internal derangement were examined. The investigation of the temporomandibular system was carried out using a 'Craniomandibular Index'. Afterwards an examiner-blinded manual medical investigation of the craniocervical system was performed. This included muscle palpation of the cervical spine and shoulder girdle as well as passive movement tests of the cervical spine, to detect restrictions in the range of movement as well as segmental intervertebral dysfunction. The internal derangement of the TMJ was significantly associated with 'silent' CSD (t-test, P temporomandibular system exhibited significantly more often pain on pressure of the neck muscles than patients without muscle tenderness of the temporomandibular system (t-test, P < 0.05). As a result of the present study, for patients with internal derangement of the TMJ an additional examination of the craniocervical system should be recommended.

    17. Silent sinus syndrome an acquired condition and the essential role of otorhinolaryngologist consultation: a retrospective study.

      Science.gov (United States)

      Martínez-Capoccioni, Gabriel; Varela-Martínez, Ernesto; Martín-Martín, Carlos

      2016-10-01

      The silent sinus syndrome (SSS) is a rare clinical entity characterized by painless spontaneous enophthalmos, hypoglobus, and facial deformities secondary to chronic maxillary sinus atelectasis. The aim of this study was to present an SSS diagnostic feature and evaluate the relationship between nasal septum deviation and maxillary sinus volume. A retrospective chart review of the clinical characteristics of 20 patients diagnosed with SSS between January 2013 and July 2014 were analyzed by the Department of Otorhinolaryngology of University Hospital Complex of Santiago de Compostela. 14 patients were females and six males. The mean age was 43 years (range 28-67 years). The right maxillary sinus was involved in 12 patients and the left maxillary sinus in eight patients. There was no statistical difference between gender and the presence of SSS. Maxillary sinus sizes were significantly smaller on the same side as the deviation (p craneo-caudal photographs. The present study demonstrates that, in adult patients, SSS generally presents a septal deviation to the affected maxillary sinus. We recommend performing a paranasal sinus CT scan when the patient has a deviated nasal septum, retraction of the malar eminence (evidenced from the viewpoint cranio-caudal facial) and hypoglobus. FESS performing postero-anterior uncinectomy and enlargement of the maxillary ostium is recommended to restore sinus pressure and prevent progression of the enophthalmos, hypoglobus and facial deformities.

    18. Packed-bed reactor/silent-discharge plasma design data report

      Energy Technology Data Exchange (ETDEWEB)

      NONE

      1996-05-01

      In 1992, Congress passed the Federal Facility Compliance Act requiring the U.S. Department of Energy (DOE) to treat and dispose of its mixed waste in accordance with Resource Conservation and Recovery Act (RCRA) land disposal restrictions (LDRs). The DOE Albuquerque Operations Office (AL) currently does not have adequate systems to treat the mixed wastes generated and stored at the nine DOE-AL sites. In response to the need for mixed-waste treatment capacity, DOE-AL organized a Treatment Selection Team under the Mixed-Waste Treatment Program (MWTP) to match mixed wastes with treatment options and develop a strategy for treatment of its mixed waste. The strategy developed by the Treatment Selection Team, as described in the AL Mixed-Waste Treatment Plan (DOE 1994), is to use available off-site commercial treatment facilities for all wastes that can be successfully and cost-effectively treated by such facilities. Where no appropriate commercial treatment facilities exist, mobile treatment units (MTUs) would be developed to treat wastes at the sites where the wastes are generated. Treatment processes used for mixed waste must not only address the hazardous component (i.e., meet LDRs) but also must contain the radioactive component in a form that allows final disposal while protecting workers, the public, and the environment. The packed-bed reactor/silent discharge plasma was chosen as a potential candidate for the treatment of the mixed wastes. The process is described.

    19. Packed-bed reactor/silent-discharge plasma design data report

      International Nuclear Information System (INIS)

      1996-05-01

      In 1992, Congress passed the Federal Facility Compliance Act requiring the U.S. Department of Energy (DOE) to treat and dispose of its mixed waste in accordance with Resource Conservation and Recovery Act (RCRA) land disposal restrictions (LDRs). The DOE Albuquerque Operations Office (AL) currently does not have adequate systems to treat the mixed wastes generated and stored at the nine DOE-AL sites. In response to the need for mixed-waste treatment capacity, DOE-AL organized a Treatment Selection Team under the Mixed-Waste Treatment Program (MWTP) to match mixed wastes with treatment options and develop a strategy for treatment of its mixed waste. The strategy developed by the Treatment Selection Team, as described in the AL Mixed-Waste Treatment Plan (DOE 1994), is to use available off-site commercial treatment facilities for all wastes that can be successfully and cost-effectively treated by such facilities. Where no appropriate commercial treatment facilities exist, mobile treatment units (MTUs) would be developed to treat wastes at the sites where the wastes are generated. Treatment processes used for mixed waste must not only address the hazardous component (i.e., meet LDRs) but also must contain the radioactive component in a form that allows final disposal while protecting workers, the public, and the environment. The packed-bed reactor/silent discharge plasma was chosen as a potential candidate for the treatment of the mixed wastes. The process is described

    20. Silent Speech Recognition as an Alternative Communication Device for Persons with Laryngectomy.

      Science.gov (United States)

      Meltzner, Geoffrey S; Heaton, James T; Deng, Yunbin; De Luca, Gianluca; Roy, Serge H; Kline, Joshua C

      2017-12-01

      Each year thousands of individuals require surgical removal of their larynx (voice box) due to trauma or disease, and thereby require an alternative voice source or assistive device to verbally communicate. Although natural voice is lost after laryngectomy, most muscles controlling speech articulation remain intact. Surface electromyographic (sEMG) activity of speech musculature can be recorded from the neck and face, and used for automatic speech recognition to provide speech-to-text or synthesized speech as an alternative means of communication. This is true even when speech is mouthed or spoken in a silent (subvocal) manner, making it an appropriate communication platform after laryngectomy. In this study, 8 individuals at least 6 months after total laryngectomy were recorded using 8 sEMG sensors on their face (4) and neck (4) while reading phrases constructed from a 2,500-word vocabulary. A unique set of phrases were used for training phoneme-based recognition models for each of the 39 commonly used phonemes in English, and the remaining phrases were used for testing word recognition of the models based on phoneme identification from running speech. Word error rates were on average 10.3% for the full 8-sensor set (averaging 9.5% for the top 4 participants), and 13.6% when reducing the sensor set to 4 locations per individual (n=7). This study provides a compelling proof-of-concept for sEMG-based alaryngeal speech recognition, with the strong potential to further improve recognition performance.

    1. The diagnosis of silent myocardial ischemia. Motion-Frozen (or morphing) myocardial perfusion imaging.

      Science.gov (United States)

      Chang, Cheng; Ye, Bo; Xie, Wenhui; Zhang, Daoliang; Lei, Bei; Ye, Xiaodan

      2016-01-01

      Silent myocardial ischemia is typically defined as objective evidence of myocardial ischemia in patients without subjective ischemia symptoms. Currently, coronary artery angiography is the gold standard for diagnosis of asymptomatic coronary artery disease (CAD). Computed tomography coronary angiography (CTCA) can visually demonstrate the morphology, trend and extent of coronary stenosis and is commonly used in clinical screening of CAD. Myocardial perfusion imaging can be used not only to identify whether anatomical stenosis causes myocardial dysfunction, but to also assess the risk stratification and prognosis of myocardial disease (MD). Myocardial perfusion imaging using morphing combined with CTCA can simultaneously show the relationship between CAD and myocardial ischemia from an anatomical and functional aspect. This allows earlier diagnosis of asymptomatic CAD myocardial ischemia, accurate identification of the culprit vessels, and could prevent unnecessary interventional therapy. The 1-day dobutamine stress/resting met-hod is also one of the methods used. The combination of CTCA and the morphing technique can provide anatomical and functional information on coronary arteries at the same time, significantly improving the diagnostic sensitivity, specificity, and accuracy of MD.

    2. Syntactically Silent Subjects: Luis Muñoz and the Poetry of Ellipsis

      Directory of Open Access Journals (Sweden)

      Judith Nantell

      2012-06-01

      Full Text Available Luis Muñoz (1966 is one of contemporary Spain’s most salient poets. His work has been described as demonstrating a discourse of ellipsis; yet no study has examined in detail his masterful use of syntactic and figurative omission. In fact, even though Muñoz’s published collections to date span two centuries, no single study has been devoted to his decidedly innovative expressivity. His work has been commented on in various panoramic essays considering contemporary poetry published in Spain at this temporal intersection and a number of his poems have been gathered into noteworthy anthologies of this same era. His poetry has been nominated for prestigious awards in Spain and in 2001 Correspondencias ‘Correspondences’ received the fourth Premio Internacional de Poesía del 27 as well as the Premio de Ojo Crítico de Poesía . The present study examines Muñoz’s most recent Querido silencio (2006 ‘Dear Silence’ where ellipsis figures prominently as the poet maximizes and exploits conceptual and linguistic efficiency. In one exemplary poem, “Dejar la poesía” ‘Leave Poetry,’ two syntactically silent subjects engage in an innovative conversation concerning the nature of poetry. At the same time this intriguing dialogue also offers a unique response to the essential question framing this poem and the collection as a whole: Why is poetry an addiction?

    3. Shortened cortical silent period in adductor spasmodic dysphonia: evidence for widespread cortical excitability.

      Science.gov (United States)

      Samargia, Sharyl; Schmidt, Rebekah; Kimberley, Teresa Jacobson

      2014-02-07

      The purpose of this study was to compare cortical inhibition in the hand region of the primary motor cortex between subjects with focal hand dystonia (FHD), adductor spasmodic dysphonia (AdSD), and healthy controls. Data from 28 subjects were analyzed (FHD n=11, 53.25 ± 8.74 y; AdSD: n=8, 56.38 ± 7.5 y; and healthy controls: n=941.67 ± 10.85 y). All subjects received single pulse TMS to the left motor cortex to measure cortical silent period (CSP) in the right first dorsal interosseus (FDI) muscle. Duration of the CSP was measured and compared across groups. A one-way ANCOVA with age as a covariate revealed a significant group effect (p<0.001). Post hoc analysis revealed significantly longer CSP duration in the healthy group vs. AdSD group (p<0.001) and FHD group (p<0.001). These results suggest impaired intracortical inhibition is a neurophysiologic characteristic of FHD and AdSD. In addition, the shortened CSP in AdSD provides evidence to support a widespread decrease in cortical inhibition in areas of the motor cortex that represent an asymptomatic region of the body. These findings may inform future investigations of differential diagnosis as well as alternative treatments for focal dystonias. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

    4. Detecting Silent Data Corruptions in Aerospace-Based Computing Using Program Invariants

      Directory of Open Access Journals (Sweden)

      Junchi Ma

      2016-01-01

      Full Text Available Soft error caused by single event upset has been a severe challenge to aerospace-based computing. Silent data corruption (SDC is one of the results incurred by soft error. SDC occurs when a program generates erroneous output with no indications. SDC is the most insidious type of results and very difficult to detect. To address this problem, we design and implement an invariant-based system called Radish. Invariants describe certain properties of a program; for example, the value of a variable equals a constant. Radish first extracts invariants at key program points and converts invariants into assertions. It then hardens the program by inserting the assertions into the source code. When a soft error occurs, assertions will be found to be false at run time and warn the users of soft error. To increase the coverage of SDC, we further propose an extension of Radish, named Radish_D, which applies software-based instruction duplication mechanism to protect the uncovered code sections. Experiments using architectural fault injections show that Radish achieves high SDC coverage with very low overhead. Furthermore, Radish_D provides higher SDC coverage than that of either Radish or pure instruction duplication.

    5. 201Tl myocardial SPECT and β-endorphin levels in patients with suspected silent ischemia

      International Nuclear Information System (INIS)

      Lind, P.; Binter, G.; Koeltringer, P.; Eber, O.; Eber, B.; Klein, W.; Brandt, D.

      1990-01-01

      Today silent myocardial ischemia (SMI) is a well-recognized phenomenon. Treadmill exercise according to the Bruce protocol, 201 Tl myocardial SPECT and coronary angiography were performed in a total of 106 patients with suspected SMI. In group I (high probability of ischemia; n=46), reversible defects detected by SPECT correlated well with significant stenoses and irreversible defects with subtotal stenoses or complete occlusions. SPECT sensitivity in the detection of ischemia was 91%, its specificity 96%. In group II (low probability of ischemia; n=60), SPECT sensitivity was as high as in group I (94%) but due to a high number of false-positive results (e.g. cardiomyopathy) specificity was only 75%. However, SPECT was superior to exercise ECG (sensitivity 70%; specificity 56%) in the detection of SMI. In addition, β-endorphin levels were determined in 180 healthy subjects, 37 patients with symptomatic CAD and in 34 patients with SMI before and during maximum exercise. Exercise values in patients with SMI were significantly higher than in healthy subjects or in patients with symptomatic CAD. (orig./MG) [de

    6. Evaluation of the sympathetic nervous system in silent ischemia with 123I-metaiodobenzylguanidine (MIBG)

      International Nuclear Information System (INIS)

      Guertner, C.; Schacherer, C.; Krause, B.J.; Zickmann, J.; Klepzig, H. Jr.; Hoer, G.

      1996-01-01

      Stress and rest myocardial perfusion scintigraphy using either Thallium-201 or 99m Tc-isonitrile was performed in SPECT technique in order to localize ischemia or scar associated perfusion defects. 15 min and 4 h p.i. static anterior 123 I-MIBG uptake was acquired. In order to localize norepinephrine depletion 4 h p.i. additional 123 I-MIBG SPECT acquistion was performed. Incidence of arrhythmias was investigated by Holter ECG. Patients with diabetes mellitus were excluded. SPECT images showed in all patients regional 123 I-MIBG depletion which corresponded with scintigraphically infarcted or ischemic regions. Well perfused myocardial regions matched with regular 123 I-MIBG utpake. There was no evidence of increased arrhythmias in long-term ECG. The finding of regular 123 I-MIBG uptake in well-perfused myocardium and infarction- or ischemia-associated regional 123 I-MIBG depletion confirms that silent ischemia is not caused by a global sympathetic nervous dysfunction in a sense of cardiac polyneuropathy. (orig.) [de

    7. Silent slips, trips and broken hips in the under 60s: A review of the literature.

      Science.gov (United States)

      Janes, Gillian; Serrant, Laura; Sque, Magi

      2018-02-24

      This critical review of the literature regarding the recovery experiences and healthcare needs of people under 60 following a fragility hip fracture seeks to identify the associated implications for nursing practice and inform care delivery. Forty papers were included following a structured database, citation and grey literature search and filtering of results in line with specified inclusion criteria. Hip fracture is a common, serious and complex injury and an important cause of morbidity, mortality and rising healthcare costs worldwide. This review indicates that although commonly associated with the elderly, incidence and impact in the under 60s has been under-explored. Current health policy, professional and social norms almost exclusively focus on the elderly, surgical interventions and short-term outcomes, rendering the under 60s an inadvertently marginalised, relatively 'silent' sub-set of the hip fracture population. Nurses must be aware, however, of the different recovery needs of this younger group. The limited evidence available indicates these include work related needs and long term physical and psychosocial limitations in this socially and economically active group. Priorities are identified for research to inform policy and practice. Meanwhile, nurses can address the needs of this group by listening to and involving them and their families as healthcare partners. Copyright © 2018. Published by Elsevier Ltd.

    8. Killing of Pseudomonas aeruginosa by Chicken Cathelicidin-2 Is Immunogenically Silent, Preventing Lung Inflammation In Vivo

      Science.gov (United States)

      Coorens, Maarten; Banaschewski, Brandon J. H.; Baer, Brandon J.; Yamashita, Cory; van Dijk, Albert; Veldhuizen, Ruud A. W.; Veldhuizen, Edwin J. A.

      2017-01-01

      ABSTRACT The development of antibiotic resistance by Pseudomonas aeruginosa is a major concern in the treatment of bacterial pneumonia. In the search for novel anti-infective therapies, the chicken-derived peptide cathelicidin-2 (CATH-2) has emerged as a potential candidate, with strong broad-spectrum antimicrobial activity and the ability to limit inflammation by inhibiting Toll-like receptor 2 (TLR2) and TLR4 activation. However, as it is unknown how CATH-2 affects inflammation in vivo, we investigated how CATH-2-mediated killing of P. aeruginosa affects lung inflammation in a murine model. First, murine macrophages were used to determine whether CATH-2-mediated killing of P. aeruginosa reduced proinflammatory cytokine production in vitro. Next, a murine lung model was used to analyze how CATH-2-mediated killing of P. aeruginosa affects neutrophil and macrophage recruitment as well as cytokine/chemokine production in the lung. Our results show that CATH-2 kills P. aeruginosa in an immunogenically silent manner both in vitro and in vivo. Treatment with CATH-2-killed P. aeruginosa showed reduced neutrophil recruitment to the lung as well as inhibition of cytokine and chemokine production, compared to treatment with heat- or gentamicin-killed bacteria. Together, these results show the potential for CATH-2 as a dual-activity antibiotic in bacterial pneumonia, which can both kill P. aeruginosa and prevent excessive inflammation. PMID:28947647

    9. Silent Crooke’s cell corticotroph adenoma of the pituitary gland presenting as delayed puberty

      Directory of Open Access Journals (Sweden)

      Dinesh Giri

      2017-03-01

      Full Text Available Corticotroph adenomas are extremely rare in children and adolescents. We present a 15-year-old boy who was investigated for delayed puberty (A1P2G1, bilateral testicular volumes of 3 mL each. There was no clinical or laboratory evidence suggestive of chronic illness, and the initial clinical impression was constitutional delay in puberty. Subsequently, MRI scan of the brain revealed the presence of a mixed cystic and solid pituitary lesion slightly displacing the optic chiasma. The lesion was removed by transphenoidal surgery and the biopsy confirmed the lesion to be pituitary adenoma. Furthermore, the adenoma cells also had Crooke’s hyaline changes and were intensely positive for ACTH. However there was no clinical/biochemical evidence of ACTH excess. There was a spontaneous pubertal progression twelve months after the surgery (A2P4G4, with bilateral testicular volume of 8 mL. Crooke’s cell adenoma is an extremely rare and aggressive variant of corticotroph adenoma that can uncommonly present as a silent corticotroph adenoma in adults. We report for the first time Crooke’s cell adenoma in an adolescent boy presenting with delayed puberty.

    10. Relationship between manic state after presenile onset and silent cerebral infarction; MRI findings and its distribution

      Energy Technology Data Exchange (ETDEWEB)

      Fujikawa, Tokumi; Yamawaki, Shigeto (Hiroshima Univ. (Japan). School of Medicine); Touhouda, Yoshikuni

      1993-11-01

      Magnetic resonance (MR) imaging was performed in 12 patients who incurred manic state after the age of 50 (manic group). Twelve other age- and sex-matched patients who incurred emotional disturbance at the young age served as controls. Patients with a history of cerebral stroke and local neurologic symptoms were excluded. Silent cerebral infarction (SCI) were concomitantly seen on MR images in 66.7% in the manic group, which was significantly higher than the control group (16.7%). Approximately half of the patients in the manic group seemed to be in the parenchymal manic state associated with SCI. Patients in the manic state associated with SCI was at a risk for developing cerebral stroke. Therefore, the treatment such as antithrombin therapy for cerebrovascular disorder was considered important, from the viewpoint of early treatment of cerebral infarction. Since lesions were frequently observed in the right frontal lobe and basal nucleus in manic patients with the associated SCI, these sites may be in part involved in the occurrence of manic state. (N.K.).

    11. Toward General Software Level Silent Data Corruption Detection for Parallel Applications

      Energy Technology Data Exchange (ETDEWEB)

      Berrocal, Eduardo; Bautista-Gomez, Leonardo; Di, Sheng; Lan, Zhiling; Cappello, Franck

      2017-12-01

      Silent data corruption (SDC) poses a great challenge for high-performance computing (HPC) applications as we move to extreme-scale systems. Mechanisms have been proposed that are able to detect SDC in HPC applications by using the peculiarities of the data (more specifically, its “smoothness” in time and space) to make predictions. However, these data-analytic solutions are still far from fully protecting applications to a level comparable with more expensive solutions such as full replication. In this work, we propose partial replication to overcome this limitation. More specifically, we have observed that not all processes of an MPI application experience the same level of data variability at exactly the same time. Thus, we can smartly choose and replicate only those processes for which the lightweight data-analytic detectors would perform poorly. In addition, we propose a new evaluation method based on the probability that a corruption will pass unnoticed by a particular detector (instead of just reporting overall single-bit precision and recall). In our experiments, we use four applications dealing with different explosions. Our results indicate that our new approach can protect the MPI applications analyzed with 7–70% less overhead (depending on the application) than that of full duplication with similar detection recall.

    12. Myocardial perfusion scintigraphy in the detection of silent ischemia in asymptomatic diabetic patients

      Energy Technology Data Exchange (ETDEWEB)

      Oki, Glaucia Celeste Rossatto [Clinica Diagnoson and Hospital Aristides Maltez, Salvador, BA (Brazil). Servicos de Medicina Nuclear; Pavin, Elizabeth Joao; Parisi, Maria Candida R. [Universidade Estadual de Campinas (Unicamp), Campinas, SP (Brazil). Department of Internal Medicine. Service of Endocrinology; Coelho, Otavio Rizzi; Almeida, Raitany C. [Universidade Estadual de Campinas (Unicamp), Campinas, SP (Brazil). Department of Internal Medicine. Service of Cardiology; Etchebehere, Elba Cristina Sa de Camargo; Ramos, Celso Dario, E-mail: cdramos@unicamp.br [Universidade Estadual de Campinas (Unicamp), Campinas, SP (Brazil). Department of Radiology. Service of Nuclear Medicine; Camargo, Edwaldo Eduardo [Hospital Sirio-Libanes, Campinas, SP (Brazil). Service of Nuclear Medicine

      2013-01-15

      Objective: This study was aimed to evaluate myocardial perfusion in asymptomatic patients with type 1 (DM1) and type 2 diabetes mellitus (DM2) without previous diagnoses of coronary artery disease (CAD) or cerebral infarction. Materials and Methods: Fifty-nine consecutive asymptomatic patients (16 DM1, 43 DM2) underwent myocardial perfusion scintigraphy with {sup 99m}Tc-sestamibi (MPS). They were evaluated for body mass index, metabolic control of DM, type of therapy, systemic arterial hypertension, dyslipidemia, nephropathy, retinopathy, peripheral neuropathy, smoking, and familial history of CAD. Results: MPS was abnormal in 15 patients (25.4%): 12 (20.3%) with perfusion abnormalities, and 3 with isolated left ventricular dysfunction. The strongest predictors for abnormal myocardial perfusion were: age 60 years and above (p = 0.017; odds ratio [OR] = 6.0), peripheral neuropathy (p = 0.028; OR = 6.1), nephropathy (p = 0.031; OR = 5.6), and stress ECG positive for ischemia (p = 0.049; OR = 4.08). Conclusion: Silent myocardial ischemia occurs in more than one in five asymptomatic diabetic patients. The strongest predictors of ischemia in this study were: patient age, peripheral neuropathy, nephropathy, retinopathy and a stress ECG positive for ischemia. (author)

    13. Myocardial perfusion scintigraphy in the detection of silent ischemia in asymptomatic diabetic patients

      International Nuclear Information System (INIS)

      Oki, Glaucia Celeste Rossatto; Pavin, Elizabeth Joao; Parisi, Maria Candida R.; Coelho, Otavio Rizzi; Almeida, Raitany C.; Etchebehere, Elba Cristina Sa de Camargo; Ramos, Celso Dario; Camargo, Edwaldo Eduardo

      2013-01-01

      Objective: This study was aimed to evaluate myocardial perfusion in asymptomatic patients with type 1 (DM1) and type 2 diabetes mellitus (DM2) without previous diagnoses of coronary artery disease (CAD) or cerebral infarction. Materials and Methods: Fifty-nine consecutive asymptomatic patients (16 DM1, 43 DM2) underwent myocardial perfusion scintigraphy with 99m Tc-sestamibi (MPS). They were evaluated for body mass index, metabolic control of DM, type of therapy, systemic arterial hypertension, dyslipidemia, nephropathy, retinopathy, peripheral neuropathy, smoking, and familial history of CAD. Results: MPS was abnormal in 15 patients (25.4%): 12 (20.3%) with perfusion abnormalities, and 3 with isolated left ventricular dysfunction. The strongest predictors for abnormal myocardial perfusion were: age 60 years and above (p = 0.017; odds ratio [OR] = 6.0), peripheral neuropathy (p = 0.028; OR = 6.1), nephropathy (p = 0.031; OR = 5.6), and stress ECG positive for ischemia (p = 0.049; OR = 4.08). Conclusion: Silent myocardial ischemia occurs in more than one in five asymptomatic diabetic patients. The strongest predictors of ischemia in this study were: patient age, peripheral neuropathy, nephropathy, retinopathy and a stress ECG positive for ischemia. (author)

    14. Ventricular Fibrillation Associated With Dynamic Changes in J-Point Elevation in a Patient With Silent Thyroiditis.

      Science.gov (United States)

      Karashima, Shigehiro; Tsuda, Toyonobu; Wakabayashi, Yusuke; Kometani, Mitsuhiro; Demura, Masashi; Ichise, Taro; Kawashiri, Masa-Aki; Takeda, Yoshiyu; Hayashi, Kenshi; Yoneda, Takashi

      2018-02-01

      A J wave is a common electrocardiographic finding in the general population. Individuals with prominent J waves in multiple electrocardiogram (ECG) leads have a higher risk of lethal arrhythmias than those with low-amplitude J waves. There are few reports about the relationship between thyroid function and J-wave amplitude. We report the case of a 45-year-old man who had unexpected ventricular fibrillation (VF). He had dynamic J-point elevation in multiple ECG leads. Possible early repolarization syndrome was diagnosed. He also had thyrotoxicosis caused by silent thyroiditis, and his J-wave amplitude decreased according to changes in thyroid function because of spontaneous remission of silent thyroiditis. There was a positive correlation between serum triiodothyronine levels and J-wave amplitudes. The findings in case suggested silent thyroiditis may contribute to the occurrence of VF in a patient with dynamic changes in J-point elevation in multiple ECG leads. Thyrotoxicosis is a relatively common endocrine disease; therefore, clinicians should pay attention to J-wave amplitude in the ECG of patients with thyrotoxicosis.

    15. Hypoxia-Induced neonatal seizures diminish silent synapses and long-term potentiation in hippocampal CA1 neurons

      Science.gov (United States)

      Zhou, Chengwen; Bell, Jocelyn J. Lippman; Sun, Hongyu; Jensen, Frances E.

      2012-01-01

      Neonatal seizures can lead to epilepsy and long-term cognitive deficits in adulthood. Using a rodent model of the most common form of human neonatal seizures, hypoxia-induced seizures (HS), we aimed to determine whether these seizures modify long-term potentiation (LTP) and “silent” N-methyl-D-aspartate receptor (NMDAR)-only synapses in hippocampal CA1. At 48-72 hours (hrs) post-HS, electrophysiology and immunofluorescent confocal microscopy revealed a significant decrease in the incidence of silent synapses, and an increase in amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) at the synapses. Coincident with this decrease in silent synapses, there was an attenuation of LTP elicited by either tetanic stimulation of Schaffer collaterals or a pairing protocol, and persistent attenuation of LTP in slices removed in later adulthood after P10 HS. Furthermore, post-seizure treatment in vivo with the AMPAR antagonist 2,3-dihydroxy-6-nitro-7-sulfonyl-benzo[f]quinoxaline (NBQX) protected against the HS-induced depletion of silent synapses and preserved LTP. Thus, this study demonstrates a novel mechanism by which early-life seizures could impair synaptic plasticity, suggesting a potential target for therapeutic strategies to prevent long-term cognitive deficits. PMID:22171027

    16. Ventricular Fibrillation Associated With Dynamic Changes in J-Point Elevation in a Patient With Silent Thyroiditis

      Science.gov (United States)

      Tsuda, Toyonobu; Wakabayashi, Yusuke; Kometani, Mitsuhiro; Demura, Masashi; Ichise, Taro; Kawashiri, Masa-aki; Takeda, Yoshiyu; Hayashi, Kenshi; Yoneda, Takashi

      2018-01-01

      A J wave is a common electrocardiographic finding in the general population. Individuals with prominent J waves in multiple electrocardiogram (ECG) leads have a higher risk of lethal arrhythmias than those with low-amplitude J waves. There are few reports about the relationship between thyroid function and J-wave amplitude. We report the case of a 45-year-old man who had unexpected ventricular fibrillation (VF). He had dynamic J-point elevation in multiple ECG leads. Possible early repolarization syndrome was diagnosed. He also had thyrotoxicosis caused by silent thyroiditis, and his J-wave amplitude decreased according to changes in thyroid function because of spontaneous remission of silent thyroiditis. There was a positive correlation between serum triiodothyronine levels and J-wave amplitudes. The findings in case suggested silent thyroiditis may contribute to the occurrence of VF in a patient with dynamic changes in J-point elevation in multiple ECG leads. Thyrotoxicosis is a relatively common endocrine disease; therefore, clinicians should pay attention to J-wave amplitude in the ECG of patients with thyrotoxicosis. PMID:29383332

    17. Silent somatotroph tumour revisited from a study of 80 patients with and without acromegaly and a review of the literature.

      Science.gov (United States)

      Chinezu, Laura; Vasiljevic, Alexandre; Trouillas, Jacqueline; Lapoirie, Marion; Jouanneau, Emmanuel; Raverot, Gérald

      2017-02-01

      Silent somatotroph tumours are growth hormone (GH) immunoreactive (IR) pituitary tumours without clinical and biological signs of acromegaly. Their better characterisation is required to improve the diagnosis. Twenty-one silent somatotroph tumours were compared to 59 somatotroph tumours with acromegaly. Tumours in each group were classified into GH and plurihormonal (GH/prolactin (PRL)/±thyroid-stimulating hormone (TSH)) and into densely granulated (DG) and sparsely granulated (SG) types. The two groups were then compared with regards to proliferation (Ki-67, p53 indexes and mitotic count), differentiation (expression of somatostatin receptors SSTR 2A -SSTR 5 and transcription factor Pit-1) and secretory activity (% of GH- and PRL-IR cells). The silent somatotroph tumours represented 2% of all tested pituitary tumours combined. They were more frequent in women than in men (P = 0.002), more frequently plurihormonal and SG (P acromegaly. They all expressed SSTR 2A , SSTR 5 and Pit-1. The plurihormonal (GH/PRL/±TSH) tumours were mostly observed in women (sex ratio: 3/1) and in patients who were generally younger than those with acromegaly (P acromegaly. A low secretory activity of these tumours might explain the normal plasma values for GH and insulin-like growth factor 1 (IGF1) and the absence of clinical signs of acromegaly. © 2017 European Society of Endocrinology.

    18. Acne polimorfo: tratamiento con Implacen

      Directory of Open Access Journals (Sweden)

      Rubén Pérez Armas

      1995-06-01

      Full Text Available Se realiza el estudio de 40 pacientes con acné polimorfo, los que fueron atendidos en la Consulta de Dermatología del Hospital Provincial Clinicoquirúrgico Docente "Celia Sánchez Manduley", en el período comprendido de enero de 1988 a diciembre de 1989. Se revisa la literatura médica sobre los diversos métodos y medicamentos utilizados en la terapéutica de esta dermatosis. Se describe el esquema de tratamiento empleado con implacén en 30 pacientes; los 10 restantes se trataron con placebo; se compara dicho esquema con los tradicionales y se observan mejores resultados con nuestro estudio. Se destaca la ausencia de recaídas, así como el resultado del tratamiento de acuerdo con el sexo.A study was performed in 40 patients presenting with polymorphic acne who were attended in the Dermatology Department of "Celia Sánchez Manduley" Clinicosurgical and Teaching Hospital from January, 1988 to December, 1989. A review of the literature was made seeking for the different methods and drugs used for the treatment of this dermatosis. The treatment schedule with the use of implacen in 30 patients is described. Such therapeutic schedule was compared with traditional ones and better results were observed with the use of implacen. The fact that there were no relapses is highlighted, as well as the result of treatment according to sex.

    19. Ausencia de circulación de poliovirus en departamentos colombianos con coberturas vacunales inferiores a 80%

      Directory of Open Access Journals (Sweden)

      María Mercedes González

      2012-08-01

      Full Text Available El presente estudio se propuso explorar la posible circulación silente de poliovirus salvajes y derivados de la vacuna (VDPV, por sus siglas en inglés, en departamentos de Colombia con cobertura de vacunación para polio (OPV, por sus siglas en inglés menor de 80%. Se colectaron 52 muestras de aguas residuales que se concentraron mediante precipitación con polietilenglicol y cloruro de sodio. La detección viral se realizó mediante aislamiento y la identificación por neutralización del efecto citopático, así como mediante reacción en cadena de la polimerasa convencional y en tiempo real, posterior a la transcripción reversa (TR-RCP y rTR-RCP. Los poliovirus aislados se caracterizaron por secuenciación del gen VP1. En dos de las 52 muestras hubo presencia de poliovirus Sabin 2 con más de 99% de similitud de secuencia con la cepa OPV Sabin 2. Se detectó circulación de enterovirus no polio en 17,3% de las muestras. Los serotipos identificados correspondieron a coxsackievirus B1, echovirus 30 y echovirus 11. No se detectaron evidencias de circulación de VDPV ni poliovirus salvaje en los departamentos de Colombia con coberturas de OPV inferiores a 80%.

    20. Costo-efectividad de medios de contraste isoosmolales e hiposmolales en pacientes con alto riesgo de nefropatía inducida por medio de contraste

      Directory of Open Access Journals (Sweden)

      Liliana Alejandra Chicaíza-Becerra

      2012-06-01

      Full Text Available Introducción. Los medios de contraste pueden provocar falla renal aguda por toxicidad directa sobre las células tubulares e isquemia medular renal. Los pacientes diabéticos y los hospitalizados presentan mayor riesgo de desarrollar nefropatía inducida por medios de contraste que la población general. Objetivo. Establecer el costo-efectividad de los medios de contraste isosmolales e hiposmolales en pacientes con alto riesgo. Materiales and métodos. El análisis se basó en una revisión sistemática de la literatura científica, comparando los efectos nefrotóxicos de los medios isosmolales e hipoosmolales. Se consideraron sólo los costos directos, obtenidos del manual tarifario. Se calcularon las tasas del incremento del costoefectividad, las curvas de eficiencia y de aceptabilidad. Se hicieron análisis univariados de sensibilidad para costos y efectos, así como probabilísticos. Se aplicaron tasas de descuento de 0 y 3 % a losresultados. Se usó como umbral de costo-efectividad por año de vida ganado, el producto interno bruto per cápita. Resultados. Las alternativas con Iopamidol y Iodixanol dominan a las demás porque reducen el riesgo de nefropatía inducida por contraste a un menor costo. La razón del incremento del costo-efectividad del iodixanol comparado con el iopamidol es de US$ 14.660 por año de vida ganado que más que duplica el umbral. Conclusión. El medio de baja osmolalidad, iopamidol, parece ser costo-efectivo comparado con iohexol u otros medios hiposmolares (iopromide, iobitridol, iomeprol, iopentol y ioxilan, en pacientes con alto riesgo de nefropatía inducida por contraste. La elección del medio hiposmolar, depende de la disponibilidad a pagar o del costo por ampolleta.   doi: http://dx.doi.org/10.7705/biomedica.v32i2.367

    1. Proteção da recuperação funcional do miocárdio pelo omeprazol após isquemia-reperfusão em corações isolados de ratos Myocardium functional recovery protection by omeprazole after ischemia-reperfusion in isolated rat hearts

      Directory of Open Access Journals (Sweden)

      Otoni Moreira Gomes

      2010-09-01

      Full Text Available OBJETIVO: Analisar efeitos do omeprazol na proteção da recuperação funcional de corações isolados de ratos submetidos à lesão de isquemia-reperfusão. MÉTODOS: Foram estudados 12 ratos Wistar, peso corpóreo médio de 280g. Após anestesia com injeção intra-abdominal de 10mg de cetamina e 2mg de xilazina, os corações foram removidos e mantidos em perfusão com solução Krebs-Henseleit (95%O2 e 5% CO2, 37ºC, 110-120mmHg de pressão de perfusão e pressão diastólica de 8 mmHg em sistema Langendorff, modificado, descartável, modelo FCSFA-ServCor (Comex Ltda.. Os seis corações do Grupo I (GI e os seis do Grupo II (GII foram submetidos a 20 minutos de isquemia e 30 minutos de reperfusão. Nos corações do Grupo II, imediatamente antes da isquemia, foram administrados via perfusão coronária 200mcg de omeprazol. Foram controlados frequência cardíaca (FC, fluxo coronário (FCo, pressão sistólica (PS, +dP/dt e -dP/dt, após estabilização (t0 e no final da reperfusão (t30. Empregou-se método não paramétrico de Kruskal-Wallis (P0,05 entre os valores de FCo e FC nos dois grupos. No final do período de reperfusão (t30, foram significantes (POBJECTIVE: To evaluate the myocardium contractility alterations of isolated hearts of rats, submitted to ischemia and reperfusion with and without administration of the omeprazole. METHODS: Twelve Wistar breed rats with 270g mean body weight was studied. After anesthesia by intraperitoneal injection of ketamine 10mg and xylazine 2mg, their hearts were removed and perfused with Krebs-Henseleit solution (95% of O2 and 5% of CO2, 37ºC, 110-120 mmHg perfusion pressure, 8 mmHg ventricular diastolic pressure in the São Francisco de Assis disposable Langendorff system model Comex Ltda, MG. The six hearts of Group I (GI and of the Group II (GII were submitted to 20 min ischemia and 30 min reperfusion. In GII hearts, intracoronary injection of omeprazole 200 mcg was done immediately before the

    2. Isquemia e reperfusão hepática total associada ao estado de choque hemorrágico controlado: efeitos no seqüestro de neutrófilos no pulmão do rato Total hepatic warm ischemia and reperfusion associated with controlled hemorrhagic shock: effects of neutrophil sequestration in lung of rats

      Directory of Open Access Journals (Sweden)

      Mario Mantovani

      2002-02-01

      Full Text Available OBJETIVO: Estudar os efeitos da isquemia e reperfusão hepática total sobre acúmulo de neutrófilos no interstício pulmonar de ratos, em condições de normalidade e submetidos ao estado de choque hemorrágico controlado. MÉTODOS: 32 ratos Wistar, machos, foram divididos em quatro grupos de oito animais cada: grupo Sham, submetido aos procedimentos padrões com um período de 60 minutos de observação; grupo Choque, submetido a choque hemorrágico controlado (PAM = 40 mmHg, 20 min. seguido de reposição volêmica (Ringer lactato + sangue, 3:1 e reperfusão (60 min.; grupo Pringle, submetido a isquemia hepática total (15 min. e reperfusão (60 min.; grupo Total submetido a choque hemorrágico controlado (15 min. seguido de reposição volêmica (Ringer lactato + sangue, 3:1 e reperfusão (60 min.. Após o sacrifício dos animais, procedeu-se à contagem de neutrófilos no interstício pulmonar. RESULTADOS: Os valores encontrados para contagem de neutrófilos no interstício pulmonar indicaram que, os animais dos grupos Pringle, Total e, também, do grupo Choque, não diferiram dos animais do grupo Sham com valores de (Sham 21,08± 14,12; Choque 35,15± 18,74; Pringle 19,78± 15,38; Total 23,90± 16,37 (p=0.253 CONCLUSÃO: Em ratos submetidos a estado de choque hemorrágico controlado associado a isquemia hepática de 15 minutos, seguida de 60 minutos de reperfusão, não ocorreu acúmulo significativo de neutrófilos no interstício pulmonar.OBJECTIVE: The purpose of this experimental work was to study the effects of total hepatic ischemia and reperfusion on the accumulation of neutrophils in the lung of rats, under normal conditions and submitted to controlled hemorrhagic shock state. METHODS: thirty two adult male Wistar rats, were divided into four groups: the Sham group, was submitted to the standard procedures for a period of 60 min. of observation; Shock group, was submitted to controlled hemorrhagic shock (PAM=40 mmHg, 20 min

    3. Prevenção do estresse oxidativo na síndrome de isquemia e reperfusão renal em ratos com suplementação nutricional com antioxidantes Prevention of oxidative stress in renal ischemia-reperfusion syndrome in rats with nutritional antioxidant supplementation

      Directory of Open Access Journals (Sweden)

      Sandro Percário

      2010-04-01

      Full Text Available OBJETIVO: Verificar o potencial efeito protetor de suplementação com vitaminas antioxidantes em um modelo de síndrome de isquemia-reperfusão renal em ratos. MÉTODOS: Foram utilizados 29 ratos Wistar, divididos em três grupos: Grupo I e II (n=10 cada, submetidos a indução do estresse oxidativo pela aplicação de 60 minutos de isquemia renal, seguidos de 10 minutos de reperfusão; adicionalmente, os animais do Grupo II foram pré-tratados por doze dias com vitaminas antioxidantes (vitamina C 11,43mg/kg e vitamina E 28,57mg/kg antes da submissão à isquemia; Grupo III (n=9, correspondendo aos animais Sham, que foram manipulados de forma equivalente aos outros grupos, porém sem indução do estresse oxidativo e sem suplementação antioxidante. Findo isso, as amostras de sangue e os rins foram colhidos para avaliação dos níveis do malondialdeído, do ácido úrico e da capacidade antioxidante total. RESULTADOS: Para o malondialdeído e ácido úrico do Grupo I foi observado um aumento estatisticamente significante (pOBJECTIVE: The objective of this study was to verify the potential protective effect of antioxidant vitamin supplementation in a model of renal ischemic-reperfusion injury in rats. METHODS: Twenty-nine Wistar rats were divided into three groups: groups I and II (n=10 each, were submitted to 60 minutes of renal ischemia, followed by 10 minutes of reperfusion; additionally, animals of group II were treated for twelve days with antioxidant vitamins (vitamin C 11.43mg/kg and vitamin E 28.5 mg/kg before being submitted to ischemia; In group III (n=9, the animals were treated like the other groups but not submitted to ischemic-reperfusion injury and not given antioxidant supplements. Subsequently, blood samples and the kidneys were collected for assessment of malondialdehyde, uric acid and total antioxidant capacity. RESULTS: The malondialdehyde and uric acid of group I was significantly higher than those of group III (p<0

    4. Silent circulation of St. Louis encephalitis virus prior to an encephalitis outbreak in Cordoba, Argentina (2005.

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      Luis Adrian Díaz

      2012-01-01

      Full Text Available St. Louis encephalitis virus is a complex zoonoses. In 2005, 47 laboratory-confirmed and probable clinical cases of SLEV infection were reported in Córdoba, Argentina. Although the causes of 2005 outbreak remain unknown, they might be related not only to virological factors, but also to ecological and environmental conditions. We hypothesized that one of the factors for SLE reemergence in Córdoba, Argentina, was the introduction of a new SLEV genotype (SLEV genotype III, with no previous activity in the area. In order to evaluate this hypothesis we carried out a molecular characterization of SLEV detections from mosquitoes collected between 2001 and 2004 in Córdoba city. A total of 315 mosquito pools (11,002 individuals including 12 mosquitoes species were analyzed. Overall, 20 pools (8 mosquitoes species were positive for SLEV. During this study, genotypes II, V and VII were detected. No mosquito pool infected with genotype III was detected before the 2005 outbreak. Genotype V was found every year and in the 8 sampled sites. Genotypes II and VII showed limited temporal and spatial activities. We cannot dismiss the association of genotype II and V as etiological agents during the outbreak. However, the silent circulation of other SLEV strains in Córdoba city before the 2005 outbreak suggests that the introduction of genotype III was an important factor associated to this event. Not mutually exclusive, other factors such as changes in avian hosts and mosquitoes vectors communities, driven by climatic and environmental modifications, should also be taken into consideration in further studies.

    5. Silent Discharge Plasma Technology for the Treatment of Air Toxics and Other Applications

      Energy Technology Data Exchange (ETDEWEB)

      Rosocha, Louis A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Chase, Peter J. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Gross, Michael P. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

      1998-09-21

      Under this CRADA, the Los Alamos National Laboratory (LANL) and High Mesa Technologies, Inc. (HMT) carried out a joint project on the development of the silent discharge plasma (SDP) technology for the treatment of hazardous air pollutants and other hazardous or toxic chemicals. The project had two major components: a technology-demonstration part and a scale-up and commercialization part. In the first part, a small-scale, mobile SDP plasma processor, which was being developed under a CRADA with the Electric Power Research Institute (EPRI) was the mobile equipment was modified for higher capacity service and employed for an innovative remediation technologies demonstration on soil-vapor extraction off-gases at the McClellan Air Force Base near Sacramento, CA. The performance of the SDP system for the variety of volatile organic compounds (VOCs) encountered at the McClellan site was sufficiently promising to the project HMT and LANL worked together to formulate a scale-up strategy and commercialization/manufacturing plan, and to design a prototype scaled-up SDP unit. HMT and LANL are now in the final stages of completing a licensing agreement for the technology and HMT is in the process of raising funds to engineer and manufacture commercial prototype SDP equipment focused on stack-gas emissions control and environmental remediation. HMT, in collaboration with another Northern New Mexico business, Coyote Aerospace, has also been successful in receiving a Phase I Small Business Innovative Research (SBIR) award from the Army Research Office to develop, design, and construct a small non-thermal plasma reactor for laboratory studies ("Non-Thermal Plasma Reactor for Control of Fugitive Emissions of Toxic Gases")

    6. A study on cognitive impairment and gray matter volume abnormalities in silent cerebral infarction patients

      International Nuclear Information System (INIS)

      Luo, Wei; Wei, Xiaofeng; Li, Mengxiong; Jiang, Xun; Li, Shanshan

      2015-01-01

      The relationship between silent cerebral infarction (SCI) and the integrity of cognitive function is unknown. We intended to investigate whether cognitive impairment is associated with gray matter volume (GMV) in the SCI patients. Sixty-two patients with SCI and 62 age- and gender-matched healthy controls (HC) were evaluated with P300 test, Montreal Cognitive Assessment (MoCA) test, Hamilton Anxiety Scale (HAMA), and Hamilton Depression Scale (HDRS). Whole brain high-resolution T1-weighted images were processed with SPM12b software and analyzed by voxel-based morphometry (VBM). Correlation analysis was performed between the GMV and the scores of MoCA Scale, P300 latency, P300 amplitude, HAMA, HDRS, age, and educational level. The brains of the SCI patients have a significant reduction in GMV in the left superior and inferior frontal gyrus, left superior temporal gyrus, right middle temporal gyrus, and bilateral hippocampus gyrus (p < 0.01, FDR correction). No significant increase of GMV was detected. The GMV of their frontal and temporal lobes is positively correlated with the score of MoCA scale and P300 amplitude (r ≥ 0.62, p < 0.01). The GMV of frontal, temporal, and hippocampus is negatively correlated with P300 latency (r ≤ -0.71, p < 0.05). No significant correlation between the GMV of abnormal brain regions and another two clinical characteristics was found. SCI patients have impaired cognitive function and reduced GMV compared to the HC subjects. The neuropathological basis of such cognitive deficits in SCI patients might be a reduced GMV. (orig.)

    7. Lysophosphatidic Acid Level and the Incidence of Silent Brain Infarction in Patients with Nonvalvular Atrial Fibrillation

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      Li Zhou

      2010-10-01

      Full Text Available Lysophosphatidic acid (LPA, which is proposed to play an important role in normal physiological situations such as wound healing, vascular tone, vascular integrity and reproduction, may be involved in the etiology of some diseases such as atherosclerosis, cancer, obesity or myocardial infarction. Abnormal findings, including silent brain infarction (SBI, are frequently observed by magnetic resonance imaging (MRI in patients with nonvalvular atrial fibrillation (NVAF. However, whether there is a relationship between LPA level and the prevalence of SBI has not been extensively studied. In the present study, the association between them was investigated. 235 patients with NVAF, 116 cases of SBI without NVAF and 120 cases of healthy volunteers (control group, who did not receive any antithrombotic therapy, were enrolled in this study. Plasma LPA levels in the NVAF with SBI group were significantly higher than that in the control group (p < 0.01, NVAF without SBI group (p < 0.01 and SBI without NVAF group (p < 0.01. The LPA levels are lower in the control group than in the NVAF without SBI and SBI without NVAF groups (p < 0.01, however, the latter two groups did not significantly differ from each other for LPA levels (p > 0.05 There were significant differences in the positive rate of platelet activation between each of the groups (p < 0.01. The positive rate of platelet activation was significantly higher in the NVAF with SBI group. We suggest that LPA might be a novel marker for estimation of the status of platelet activation and the risk factor for SBI onset in NVAF patients. We expected that plasma LPA levels could predict the occurrence of SBI in NVAF patients.

    8. SILENT MYOCARDIAL ISCHEMIA AND CARDIAC RHYTHM DISTURBANCES IN WOMEN WITH RHEUMATOID ARTHRITIS

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      D. S. Novikova

      2014-07-01

      Full Text Available Objective: to assess the rate of silent myocardial ischemia (SMI and the pattern of cardiac rhythm disturbances in women with rheumatoidarthritis (RA, their association with traditional risk factors (TRF for cardiovascular diseases (CVD, with subclinical structural and functionalchanges in the heart and vessels, with the activity and severity of rheumatoid inflammation.Subjects and methods. Two hundred and ninety-one female patients aged less than 60 years with a valid diagnosis of RA and no clinicalsigns were examined. A control group consisted of 125 women without rheumatic diseases. In addition to the clinical manifestations, activity,and severity of RA, the authors assessed major TRFs for CVD, performed Holter ECG monitoring, common carotid artery duplex scanning, transthoracic echocardiographic study, and determined the levels of serum inflammatory markers.Results. The women with RA differ from the control group in the higher incidence of SMI, supraventricular arrhythmias (SVA and highgradepremature ventricular contractions (PVC. The patients with RA and SMI are characterized in terms of age-adjustment by higher disease activity (DAS28, systemic manifestations, cumulative larger-dose glucocorticoids (GC and a higher percentage of patients receiving disease-modifying anti-rheumatic drugs as compared with those with RA and no SMI with adjustment for age. High disease activity(DAS28, level of inflammatory markers, IgM rheumatoid arthritis seropositivity, and GC therapy are SVA-associated factors in women with RA; larger left ventricular end-diastolic dimension and serositis are factors associated with high-grade PVC.Conclusion. The RA women without clinical manifestations of CVD are recorded to have high rates of SMI, SVA, and high-grade PVC, which is primarily due to the activity and severity of rheumatoid inflammation.

    9. Incidence and predictors of silent embolic cerebral infarction following diagnostic coronary angiography.

      Science.gov (United States)

      Kim, In-Cheol; Hur, Seung-Ho; Park, Nam-Hee; Jun, Dong-Hwan; Cho, Yun-Kyeong; Nam, Chang-Wook; Kim, Hyungseop; Han, Seong-Wook; Choi, Sae-Young; Kim, Yoon-Nyun; Kim, Kwon-Bae

      2011-04-14

      Coronary angiography (CAG) is an invasive diagnostic procedure, which could lead to procedure related complications. One of the well known post-procedural complications is cerebral embolic infarction with or without symptoms. Silent embolic cerebral infarction (SECI) has clinical significance because it can progress to a decline in cognitive function and increase the risk of dementia in the long term. The aim of this study was to detect the incidence and predictors of SECI after diagnostic CAG using diffusion-weighted magnetic resonance imaging (DW-MRI). A total of 197 patients with coronary artery disease who underwent DW-MRI for evaluation of intracranial vasculopathy before coronary artery bypass graft surgery were retrospectively enrolled in the present study. DW-MRI was performed within 48 h after diagnostic CAG. SECI was diagnosed as presence of focal bright high signal intensity in DW-MRI. Patients were divided into groups according to presence/absence of SECI (+ SECI vs. - SECI, respectively). The clinical and angiographic characteristics were analyzed and independent predictors were evaluated. Of the 197 patients, SECI occurred in 20 patients (10.2%) after diagnostic CAG. Age, female gender, frequency of underlying atrial fibrillation, extent of coronary disease, and fluoroscopic time during diagnostic CAG were not different between the + SECI and - SECI groups. Left ventricular ejection fraction was significantly lower in the + SECI group than in the - SECI group (45.9 ± 8.5% vs. 51.4 ± 13.1%, p=0.014) and performance rate of internal mammary artery (IMA) angiography was significantly higher in the + SECI group compared with the - SECI group (85% vs. 37.2%, pSECI (OR=14.642; 95% CI=3.201 to 66.980, p=0.001). The incidence of SECI after diagnostic CAG was not infrequent. Diagnostic CAG with IMA angiography may increase the risk of SECI. Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.

    10. Insufficient platelet inhibition is related to silent embolic cerebral infarctions after coronary angiography.

      Science.gov (United States)

      Kim, Bum Joon; Lee, Seung-Whan; Park, Seong-Wook; Kang, Dong-Wha; Kim, Jong S; Kwon, Sun U

      2012-03-01

      Considering that insufficient platelet inhibition is related to thrombotic complications after coronary angiography, we hypothesized that the extent of platelet inhibition by antiplatelet agents is related to the occurrence of silent embolic cerebral infarction (SECI) after coronary angiography. Among the patients scheduled for coronary artery bypass surgery, we retrospectively analyzed the location of SECI on diffusion-weighted imaging of 272 patients, which was performed after coronary angiography, as a presurgical evaluation in Phase 1 study. In Phase 2 study, we have prospectively recruited 102 patients to compare the extent of platelet inhibition measured by the VerifyNow system among patients with and without SECI. SECI is observed in 45 patients (16.5%) in Phase 1 and 17 (16.7%) in Phase 2. The lesions were slightly more frequent in the right hemisphere. In the Phase 2 study, aspirin reaction units and P(2)Y(12) reaction units were higher in the patients with SECI than those without (aspirin reaction units: 490±72 versus 446±53, P=0.03; P(2)Y(12) reaction units: 352±65 versus 300±77, P=0.009). The incidence of SECI increased with the number of resistant antiplatelets; resistance to both antiplatelet agent (50%), resistance to 1 antiplatelet agent (22%), and no resistance (4%; P=0.023). From the result of logistic regression, higher aspirin reaction units, white blood cell count, low hemoglobin, and nonresponsiveness to antiplatelet agents were independent risk factors. Insufficient platelet inhibition after administration of antiplatelet agents is related with SECI appearing after coronary angiography.

    11. Network-Based Integration of Disparate Omic Data To Identify "Silent Players" in Cancer.

      Directory of Open Access Journals (Sweden)

      Matthew Ruffalo

      2015-12-01

      Full Text Available Development of high-throughput monitoring technologies enables interrogation of cancer samples at various levels of cellular activity. Capitalizing on these developments, various public efforts such as The Cancer Genome Atlas (TCGA generate disparate omic data for large patient cohorts. As demonstrated by recent studies, these heterogeneous data sources provide the opportunity to gain insights into the molecular changes that drive cancer pathogenesis and progression. However, these insights are limited by the vast search space and as a result low statistical power to make new discoveries. In this paper, we propose methods for integrating disparate omic data using molecular interaction networks, with a view to gaining mechanistic insights into the relationship between molecular changes at different levels of cellular activity. Namely, we hypothesize that genes that play a role in cancer development and progression may be implicated by neither frequent mutation nor differential expression, and that network-based integration of mutation and differential expression data can reveal these "silent players". For this purpose, we utilize network-propagation algorithms to simulate the information flow in the cell at a sample-specific resolution. We then use the propagated mutation and expression signals to identify genes that are not necessarily mutated or differentially expressed genes, but have an essential role in tumor development and patient outcome. We test the proposed method on breast cancer and glioblastoma multiforme data obtained from TCGA. Our results show that the proposed method can identify important proteins that are not readily revealed by molecular data, providing insights beyond what can be gleaned by analyzing different types of molecular data in isolation.

    12. A study on cognitive impairment and gray matter volume abnormalities in silent cerebral infarction patients

      Energy Technology Data Exchange (ETDEWEB)

      Luo, Wei; Wei, Xiaofeng; Li, Mengxiong [The First Affiliated Hospital of Yangtze University, Biomedical Engineering Laboratory, Jingzhou, Hubei (China); Jiang, Xun [Renmin Hospital of Wuhan University, Biomedical Engineering Laboratory, Wuhan, Hubei (China); Li, Shanshan [JingZhou City Central Blood Bank, Jingzhou, Hubei (China)

      2015-08-15

      The relationship between silent cerebral infarction (SCI) and the integrity of cognitive function is unknown. We intended to investigate whether cognitive impairment is associated with gray matter volume (GMV) in the SCI patients. Sixty-two patients with SCI and 62 age- and gender-matched healthy controls (HC) were evaluated with P300 test, Montreal Cognitive Assessment (MoCA) test, Hamilton Anxiety Scale (HAMA), and Hamilton Depression Scale (HDRS). Whole brain high-resolution T1-weighted images were processed with SPM12b software and analyzed by voxel-based morphometry (VBM). Correlation analysis was performed between the GMV and the scores of MoCA Scale, P300 latency, P300 amplitude, HAMA, HDRS, age, and educational level. The brains of the SCI patients have a significant reduction in GMV in the left superior and inferior frontal gyrus, left superior temporal gyrus, right middle temporal gyrus, and bilateral hippocampus gyrus (p < 0.01, FDR correction). No significant increase of GMV was detected. The GMV of their frontal and temporal lobes is positively correlated with the score of MoCA scale and P300 amplitude (r ≥ 0.62, p < 0.01). The GMV of frontal, temporal, and hippocampus is negatively correlated with P300 latency (r ≤ -0.71, p < 0.05). No significant correlation between the GMV of abnormal brain regions and another two clinical characteristics was found. SCI patients have impaired cognitive function and reduced GMV compared to the HC subjects. The neuropathological basis of such cognitive deficits in SCI patients might be a reduced GMV. (orig.)

    13. President Rawlings stays silent despite OAU challenge -- an "absence of interest"?

      Science.gov (United States)

      Dodd, R

      1995-12-01

      Ghana's response to AIDS lacks high-level political commitment. This complacency is dangerous. Since 1986 about 16,000 AIDS cases in Ghana have been reported. HIV infection affects about 4% of the adult population; 2-4% of women at prenatal clinics and 6-8% of sexually transmitted disease (STD) patients are infected. Ghana's annual economic growth of 5% induces rural-urban migration and the spread of prostitution. The National Technical Committee on AIDS was formed in 1985, and the first plan of action ran from 1989 to 1993. It covered information, education, and communication, safety of blood supply, and training for health workers in AIDS care. A 1993 survey showed that 90-95% of people know that AIDS is an STD, but only 20% had ever used condoms. The National AIDS Program (NAP) experienced delay in getting its second medium-term plan finalized once the first plan expired in 1993. About 80% of NAP is financed by external donors, and similarly, a greater part of Ghana's health budget is financed externally. International financial institutions have put pressure on Ghana to boost its economic performance as a favorite model. This also means that while the government focuses on economic growth, social sectors are less well-cared for. NAP developed an AIDS impact model to try to get more government help, but without much success. The ministries of education and agriculture carry out some AIDS work, but other activities remain minimal. The minister of health has instituted an annual AIDS awareness month and exempted AIDS patients from paying hospital fees. The AIDS awareness month is each November just prior to World AIDS Day. Despite the availability of donor money, the existing infrastructure cannot absorb it. The main indicator of progress about AIDS is the increased openness about sexual issues. Religious leaders have been silently supportive of condom promotion, and its use is increasing.

    14. Lengthened Cutaneous Silent Period in Fibromyalgia Suggesting Central Sensitization as a Pathogenesis.

      Directory of Open Access Journals (Sweden)

      Seol-Hee Baek

      Full Text Available The pathogenesis of fibromyalgia (FM has not been clearly elucidated, but central sensitization, which plays an important role in the development of neuropathic pain, is considered to be the main mechanism. The cutaneous silent period (CSP, which is a spinal reflex mediated by A-delta cutaneous afferents, is useful for the evaluation of sensorimotor integration at the spinal and supraspinal levels. To understand the pathophysiology of FM, we compared CSP patterns between patients with FM and normal healthy subjects. Twenty-four patients with FM diagnosed in accordance with the 1990 American College of Rheumatology classification system and 24 age- and sex-matched healthy volunteers were recruited. The CSP was measured from the abductor pollicis brevis muscle. Demographic data, number of tender points, and visual analog scale and FM impact questionnaire scores were collected. The measured CSP and clinical parameters of the patient and control groups were compared. In addition, possible correlations between the CSP parameters and the other clinical characteristics were analyzed. Mean CSP latencies did not differ between patients (55.50 ± 10.97 ms and healthy controls (60.23 ± 11.87 ms; p = 0.158, although the mean CSP duration was significantly longer in patients (73.75 ± 15.67 ms than in controls (63.50 ± 14.05 ms; p = 0.021. CSP variables did not correlate with any clinical variables. The significantly longer CSP duration in FM patients suggests central dysregulation at the spinal and supraspinal levels, rather than peripheral small fiber dysfunction.

    15. Cortical Silent Period Reveals Differences Between Adductor Spasmodic Dysphonia and Muscle Tension Dysphonia.

      Science.gov (United States)

      Samargia, Sharyl; Schmidt, Rebekah; Kimberley, Teresa Jacobson

      2016-03-01

      The pathophysiology of adductor spasmodic dysphonia (AdSD), like other focal dystonias, is largely unknown. The purposes of this study were to determine (a) cortical excitability differences between AdSD, muscle tension dysphonia (MTD), and healthy controls; (b) distribution of potential differences in cranial or skeletal muscle; and (c) if cortical excitability measures assist in the differential diagnosis of AdSD and MTD. Ten participants with adductor spasmodic dysphonia, 8 with muscle tension dysphonia, and 10 healthy controls received single and paired pulse transcranial magnetic stimulation (TMS) to the primary motor cortex contralateral to tested muscles, first dorsal interosseus (FDI), and masseter. We tested the hypothesis that cortical excitability measures in AdSD would be significantly different from those in MTD and healthy controls. In addition, we hypothesized that there would be a correlation between cortical excitability measures and clinical voice severity in AdSD. Cortical silent period duration in masseter and FDI was significantly shorter in AdSD than MTD and healthy controls. Other measures failed to demonstrate differences. There are differences in cortical excitability between AdSD, MTD, and healthy controls. These differences in the cortical measure of both the FDI and masseter muscles in AdSD suggest widespread dysfunction of the GABAB mechanism may be a pathophysiologic feature of AdSD, similar to other forms of focal dystonia. Further exploration of the use of TMS to assist in the differential diagnosis of AdSD and MTD is warranted. © The Author(s) 2015.

    16. Importance of anticoagulation and postablation silent cerebral lesions: Subanalyses of REVOLUTION and reMARQable studies.

      Science.gov (United States)

      Grimaldi, Massimo; Swarup, Vijay; DeVille, Brian; Sussman, Jonathan; Jaïs, Pierre; Gaita, Fiorenzo; Duytschaever, Mattias; Ng, G Andre; Daoud, Emile; Lakkireddy, Dhanunjaya Dj; Horton, Rodney; Wickliffe, Andrew; Ellis, Christopher; Geller, Laszlo

      2017-12-01

      Silent cerebral lesions (SCLs) are a potential complication of left atrial radiofrequency ablation (RFA) procedures for paroxysmal atrial fibrillation (PAF). We aimed to compare the incidence of SCLs in patients treated with irrigated RFA multielectrode catheters (nMARQ ® Catheter group) and irrigated focal RFA catheters (NAVISTAR ® THERMOCOOL ® Catheter; TC group) after PAF ablation from subpopulation neurological assessment (SNA) cohorts of the REVOLUTION and reMARQable studies. Data from SNA cohorts in the prospective, nonrandomized REVOLUTION study (March 2011-September 2013) and the prospective, randomized, controlled reMARQable study (October 2013-November 2015) were included. The incidence of SCLs was assessed pre- and postablation using magnetic resonance imaging. Neurological deficits were assessed using the National Institutes of Health Stroke Scale, modified Rankin Scale, and Montreal Cognitive Assessment. A total of 37 patients from REVOLUTION and 76 patients from reMARQable were included in the SNA cohort of each study. In the REVOLUTION SNA cohort, the incidence of SCLs was 21.1% (4/19) in the nMARQ ® Catheter group and 5.9% (1/17) in the TC group. Findings from REVOLUTION helped inform the reMARQable study protocol's stringent anticoagulation regimen. SCL incidence was subsequently reduced in both groups (nMARQ ® Catheter, 7.9%; TC, 3.3%). No permanent neurological deficits were observed. Adherence to a stringent anticoagulation regimen prior to and during ablation procedures appears to be an important factor in minimizing the risk of SCL. © 2017 Wiley Periodicals, Inc.

    17. Angiographic and functional comparison of patients with silent and symptomatic treadmill ischemia early after myocardial infarction

      International Nuclear Information System (INIS)

      Ouyang, P.; Shapiro, E.P.; Chandra, N.C.; Gottlieb, S.H.; Chew, P.H.; Gottlieb, S.O.

      1987-01-01

      Sixty consecutive patients were studied who had positive responses to Naughton exercise treadmill testing (at least 1.5 mm of ST-segment shift in at least 2 leads or thallium reperfusion abnormalities) with or without symptoms of angina 11 +/- 1 days after acute myocardial infarction (AMI). All patients had undergone coronary angiography 24 +/- 4 days after infarction. Thirty-eight patients (63%) had no treadmill angina (silent ischemia, group I) and 22 patients had typical treadmill angina (symptomatic ischemia, group II). Use of beta-blocking drugs, calcium antagonists and nitrates at the time of exercise testing did not differ in the 2 groups. All 9 patients with diabetes mellitus were in the asymptomatic group (p less than 0.40) and group I had a greater proportion of inferior wall AMI (30 of 38) than group II (11 of 22, p = 0.02). Total exercise treadmill test duration (group I 422 +/- 31 seconds, group II 400 +/- 46 seconds) and rate-pressure product were not different in the 2 groups. The number of patients unable to exercise 5 minutes (12 in group I and 7 in group II), the number with diffuse electrocardiographic changes (9 in group I and 7 in group II), and the number with inadequate blood pressure response (8 in group I and 4 in group II) were also similar. At coronary arteriography the mean number of arteries with at least 70% diameter stenosis was 2.0 +/- 0.2 in group I and 2.2 +/- 0.2 in group II (difference not significant)

    18. 45. Ezetimibe and statins yields on silent holter ambulatory myocardial ischemia

      Directory of Open Access Journals (Sweden)

      W. Kadro

      2016-07-01

      Full Text Available Further cholestrol lowering may affect silent ischemia detected on holter monitoring. Cholesterol lowering is associated with a reduction in cardiovascular morbidity and mortality. Statins are the main drugs for cholesterol lowering. Ezetimibe when added to statins gives further reduction in cholesterol but its long-term effect on cardiovascular morbidity and mortality and ischemic events is not known. This study sought to determine whether further cholesterol lowering with ezitimibe will also results in a reduction of myocardial ischemia during daily life. We enrolled 50 patients with proven stable coronary artery disease (CAD and at least one episode of ST-segment depression on ambulatory ECG monitoring. All of them were receiving optimal therapy for CAD including statin therapy for cholesterol reduction. 25 patients were randomized to continue their statin therapy (Statin only group and 25 to recieve statin plus ezitimibe 10 mg/day (ezitimibe group. Serum cholesterol and LDL cholesterol levels and ambulatory monitoring were repeated after 4–6 months of therapy. The two groups were comparable with respect to baseline characteristics, number of episodes of ST-segment depression, and baseline serum cholesterol levels. The ezitimibe group had lower mean total and LDL cholesterol levels at study end and experienced a significant reduction in the number of episodes of ST-segment depression compared with the statin only group. ST-segment depression was completely resolved in 13 of 25 patients (52% in the ezitimibe group versus 3 of 25 (12% in the statin only group. The ezitimibe group exhibited a highly significant reduction in ambulatory ischemia (P < .001. By logistic regression, treatment with ezitimibe was an independent predictor of ischemia resolution. Further cholesterol lowering with ezitimibe can result in reduction or resolution of myocardial ischemia recorded as episodes of ST-segment depression in ambulatory monitoring of the ECG.

    19. Silent gastro-esophageal reflux in children presenting with recurrent lower respiratory tract infections

      International Nuclear Information System (INIS)

      Thomas, E.J.; Bharathi Dasan, J.; Kumar, R.; Chanderashekher, N.; Tripathi, M.; Kabra, S.K.; Malhotra, A.; Kumar, A.; Menon, S.

      2002-01-01

      Introduction: Paediatric respiratory tract infections are one of the most common reasons for physician visits and hospitalisation, and are associated with significant morbidity and mortality. The socioeconomic impact of these recurrent infections is staggering. Gastroesophageal reflux (GER) has long been associated with pulmonary symptoms and diseases. Aims: The present retrospective analysis was undertaken to find out the incidence of GER in children suffering from recurrent lower respiratory tract infections without any typical gastrointestinal (GI) symptoms of GER. Materials and Methods: A total of 297 children with a mean age of 2.7 years and range 9-months to 8 years were evaluated. All studies were performed using a dose of 100-200 micro Curie (3.7-7.4MBq) of Tc99m-sulphur colloid, which was administered via a nasogastric tube into the stomach in younger children. Adequate intragastric volume was ensured by instilling water of 50-ml volume for children less than 6 months and 100-ml volume for children between 6-12 months of age. The nasogastric tube was removed with the patient held in erect position and a small volume of water was pushed to avoid any contamination. In older children the isotope was administered in a capsule and was swallowed with 150-300 ml of water. Results: Of the total 297 children, 111(37%) children had GER on scintigraphy. Conclusion: There is a high incidence of silent GER in children suffering from recurrent lower respiratory tract infections. Scintiscanning can be used as a screening modality in these children

    20. The influences of silent cerebral infarction and hypertension on brain atrophy in normal adults

      International Nuclear Information System (INIS)

      Zhefeng, Quan; Bokura, Hirokazu; Iijima, Kenichi; Oguro, Hiroaki; Yamaguchi, Shuhei

      2008-01-01

      We studied the influences of silent brain infarction (SBI) and hypertension on brain atrophy and its longitudinal progression in healthy adults. MRI scans were performed on 109 neurologically normal adults (mean age, 58.6±5.8 years), with follow-up at an average of 4.9 years later. Patient histories of hypertension, smoking habits, and alcohol consumption were examined. We evaluated brain atrophy using the brain atrophy index (BAI; the ratio of the brain area to the intracranial area) and the ventricular atrophy index (VAI; the ratio of the ventricular area to the brain area) on MRI T1-weighted images at the levels of the basal ganglia and lateral ventricle in horizontal sections. There were no differences in age, sex, dyslipidemia, body mass index (BMI), smoking habit, and alcohol consumption between the normal group and the SBI or hypertension group. The BAI was significantly lower at entry for the SBI (+) group than for the SBI (-) group at both the basal ganglia and lateral ventricle levels (basal ganglia level, p=0.02; and lateral ventricle level, p=0.05). Moreover, the VAI was significantly higher at entry for the SBI (+) group than for the SBI (-) group at the lateral ventricle level (p=0.03). Furthermore, the BAI was significantly lower at entry for the hypertensive group than for the non-hypertensive group at the basal ganglia level (p=0.007). There were no significant differences in the annual variations of the BAI and VAI between the normal group and the SBI (+) or hypertensive group. The present results suggest that the SBI and hypertension are accelerating factors for brain atrophy and ventricular dilatation. (author)

    1. The influences of silent cerebral infarction and hypertension on brain atrophy in normal adults

      Energy Technology Data Exchange (ETDEWEB)

      Zhefeng, Quan; Bokura, Hirokazu; Iijima, Kenichi; Oguro, Hiroaki; Yamaguchi, Shuhei [Shimane Univ., Faculty of Medicine, Izumo, Shimane (Japan)

      2008-03-15

      We studied the influences of silent brain infarction (SBI) and hypertension on brain atrophy and its longitudinal progression in healthy adults. MRI scans were performed on 109 neurologically normal adults (mean age, 58.6{+-}5.8 years), with follow-up at an average of 4.9 years later. Patient histories of hypertension, smoking habits, and alcohol consumption were examined. We evaluated brain atrophy using the brain atrophy index (BAI; the ratio of the brain area to the intracranial area) and the ventricular atrophy index (VAI; the ratio of the ventricular area to the brain area) on MRI T1-weighted images at the levels of the basal ganglia and lateral ventricle in horizontal sections. There were no differences in age, sex, dyslipidemia, body mass index (BMI), smoking habit, and alcohol consumption between the normal group and the SBI or hypertension group. The BAI was significantly lower at entry for the SBI (+) group than for the SBI (-) group at both the basal ganglia and lateral ventricle levels (basal ganglia level, p=0.02; and lateral ventricle level, p=0.05). Moreover, the VAI was significantly higher at entry for the SBI (+) group than for the SBI (-) group at the lateral ventricle level (p=0.03). Furthermore, the BAI was significantly lower at entry for the hypertensive group than for the non-hypertensive group at the basal ganglia level (p=0.007). There were no significant differences in the annual variations of the BAI and VAI between the normal group and the SBI (+) or hypertensive group. The present results suggest that the SBI and hypertension are accelerating factors for brain atrophy and ventricular dilatation. (author)

    2. con mala calidad de vida

      Directory of Open Access Journals (Sweden)

      Agustín Martín-Rodríguez

      2007-01-01

      Full Text Available En este estudio ex post facto se ha analizado si los familiares de pacientes con mala calidad de vida presentan diferencias en las variables clínicas de personalidad y relaciones familiares en función de que el paciente haya estado o no ingresado en una Unidad de Cuidados Intensivos. Seleccionamos dos grupos: 29 familiares de pacientes traumatizados graves transcurridos cuatro años de su ingreso en una UCI de Traumatología y con mala calidad de vida (debido a secuelas físicas y/o psicológicas tras el ingreso, tales como traumatismos craneoencefálicos, politraumatismos y tetraplejias traumáticas y 32 familiares de pacientes con mala calidad de vida con cuatro años de evolución de su enfermedad física (hipertensión, diabetes, artritis reumatoide y síndrome de intestino irritable que no han estado ingresados en la UCI. Para alcanzar nuestro objetivo empleamos una Encuesta Psicosocial y los siguientes instrumentos: Cuestionario de Análisis Clínico, Escala de Clima Social en la Familia y Escala de Adaptación Psicosocial de la Enfermedad. Los resultados mostraron que los familiares de pacientes con mala calidad de vida que estuvieron ingresados en la UCI hace cuatro años, presentan diferencias significativas en las variables agitación y expresividad comparados con los familiares de pacientes con mala calidad de vida que no han estado ingresados en la UCI.

    3. Disfunção endotelial após isquemia global e reperfusão em cirurgia cardíaca com circulação extracorpórea: estudo do papel do magnésio em artérias coronarianas caninas

      Directory of Open Access Journals (Sweden)

      Marco A. VOLPE

      2002-09-01

      Full Text Available OBJETIVO: Estudar a disfunção endotelial conseqüente à lesão provocada por isquemia global seguida de reperfusão e a potencial influência protetora do magnésio sobre a integridade funcional do endotélio em coronárias isoladas de cães. MÉTODO: Segmentos de artérias coronárias caninas foram suspensos em banhos orgânicos para medida de força isométrica. A disfunção endotelial foi avaliada pela capacidade destes segmentos produzirem óxido nítrico, alterando a força isométrica inicial. Foram selecionados quatro grupos com seis cães em cada um: SEM CEC (controle, CEC (110 minutos de perfusão sem isquemia, ISQ (45 minutos de isquemia, ISQ/REP (45 minutos de isquemia seguidos de 60 minutos de reperfusão. A ação do magnésio foi avaliada em três fases: I (banho orgânico com magnésio, II (banho orgânico sem magnésio e III (banho orgânico com magnésio restaurado. Foram utilizados três agonistas farmacológicos que representam os principais passos da via de produção do óxido nítrico: receptor de membrana da célula endotelial - acetilcolina (ACh; transdução do sinal entre o receptor e os processos intracelulares através da G-proteína - fluoreto de sódio (NaF; liberação dos estoques intracelulares de cálcio - cálcio ionóforo (A23187. Ao estudo da função endotelial associou-se a avaliação da atividade da musculatura lisa dependente de GMPc - nitroprussiato de sódio (NPS. RESULTADOS: Os principais achados desta investigação foram: 1 a presença de magnésio no perfusato pareceu atenuar a disfunção endotelial causada por isquemia global seguida de reperfusão; 2 a presença de magnésio no banho orgânico (fase I associou-se a maior relaxamento em resposta aos agonistas da produção de óxido nítrico; 3 a remoção de magnésio do banho orgânico (fase II esteve associada à redução na intensidade do relaxamento em resposta aos agonistas da produção de óxido nítrico; 4 a restauração de magn

    4. Tratamiento con implantes Leader-Nano en paciente con oligodoncia

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      Salvador Javier Santos Medina

      2015-03-01

      Full Text Available Los implantes dentales de titanio han revolucionado el mundo de la rehabilitación desde su surgimiento. De manera particular, el empleo de implantes de carga inmediata acorta el tiempo quirúrgico y protésico, con el consiguiente bienestar estético. Se presenta el caso de una paciente femenina de 32 años de edad, con antecedentes de oligodoncia de ambos incisivos laterales superiores y portadora de prótesis parcial acrílica. Fue atendida por el equipo multidisciplinario de implantes en la Clínica Estomatológica Docente “3 de Octubre” y se le realizó tratamiento de rehabilitación integral con implantes Leader-Nano y prótesis fija con corona acrílica sobre dichos implantes. La implantología fue satisfactoria en la paciente; la mejoría estética y funcional, así como la satisfacción de la paciente, fueron los principales logros obtenidos

    5. Negotiating Colonial Korean Cinema in the Japanese Empire: From the Silent Era to the Talkies, 1923-1939

      Directory of Open Access Journals (Sweden)

      Chonghwa Chung

      2012-12-01

      Full Text Available This article examines what I call a “system of cooperation” (K. hyŏp’ŏp, J. kyōgyō, 協業 in the colonial Korean film industry from 1923, when silent films appeared, to the late 1930s, when colonial cinema was restructured within an imperial wartime system. In other words, this article examines the interworking of colonial Korean and imperial Japanese cinema from Yun Hae-dong’s “colonial modern” perspective in order to go beyond the long established lens on colonial Korean film and film historiography that merely focused on the contributions of colonial Korean filmmakers. Here the author rather focuses on the cooperation or collaboration between Japan and Korea: Japanese directors and cinematographers working in Korea, Korean filmmakers with experience in the Japanese apprenticeship system, and filmmakers working together and independently during the silent film era. During the transition from the silent to the early talkie eras, second-generation filmmakers, especially those who trained in film studios in Japan, were significant. They dreamed of the corporatization of the colonial Korean film industry and took the lead in coproductions between Japanese film companies and their colonial Korean counterparts. Korean filmmakers were not unilaterally suppressed by imperial Japan, nor did they independently operate within the Korean film industry during the colonial period. The Japanese in colonial Korea did not take the lead in forming the colonial Korean film scene, either. The core formation of colonial Korean / Korean film was a process of Korean and Japanese filmmakers in competition and negotiation with one another within a complex film sphere launched with Japanese capital and technology.

    6. The association between saliva control, silent saliva penetration, aspiration, and videofluoroscopic findings in Parkinson′s disease patients

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      Ali Rajaei

      2015-01-01

      Full Text Available Background: Dysphagia is a common disorder among patients with Parkinson′s disease (PD. It occurs in up to 80% of all (PD patients during the early stages of the disease and up to 95% in the advanced stages; but professionals may not hear from the patients about dysphagia symptoms until these symptoms reach an advanced stage and lead to medical complications. Materials and Methods: Thirty-three PD patients (mean age 66.09 ± 9.4 years; 24 men, nine women participated in this study at our Neurology Institute, between April 20, 2013, and October 26, 2013. They were asked two questions; one about saliva control and the other about silent saliva penetration and aspiration. Next, they underwent the videofluoroscopic swallowing study (VFSS. Results: The Pearson Correlation coefficient between the Penetration-Aspiration Scale (PAS scores and question 1 scores was 0.48 (P < 0.05, =0.25, and there was a significant correlation between the PAS scores and question 2 scores, and also question 1 scores + question 2 scores (r = 0.589, P < 0.05, =0 and r = 0589, P < 0.05, =0. Conclusions: This study showed a significant correlation between the questions about saliva control, silent saliva penetration, and aspiration, and laryngeal penetration and aspiration during VFSS. Therefore, by using these two questions, the potential silent laryngeal penetration and aspiration during meals could be detected before it led to aspiration pneumonia. Taking the benefit of these questions, as a part of the swallowing assessment of PD patients, is recommended.

    7. Measuring theory of mind across middle childhood: Reliability and validity of the Silent Films and Strange Stories tasks.

      Science.gov (United States)

      Devine, Rory T; Hughes, Claire

      2016-09-01

      Recent years have seen a growth of research on the development of children's ability to reason about others' mental states (or "theory of mind") beyond the narrow confines of the preschool period. The overall aim of this study was to investigate the psychometric properties of a task battery composed of items from Happé's Strange Stories task and Devine and Hughes' Silent Film task. A sample of 460 ethnically and socially diverse children (211 boys) between 7 and 13years of age completed the task battery at two time points separated by 1month. The Strange Stories and Silent Film tasks were strongly correlated even when verbal ability and narrative comprehension were taken into account, and all items loaded onto a single theory-of-mind latent factor. The theory-of-mind latent factor provided reliable estimates of performance across a wide range of theory-of-mind ability and showed no evidence of differential item functioning across gender, ethnicity, or socioeconomic status. The theory-of-mind latent factor also exhibited strong 1-month test-retest reliability, and this stability did not vary as a function of child characteristics. Taken together, these findings provide evidence for the validity and reliability of the Strange Stories and Silent Film task battery as a measure of individual differences in theory of mind suitable for use across middle childhood. We consider the methodological and conceptual implications of these findings for research on theory of mind beyond the preschool years. Copyright © 2015 Elsevier Inc. All rights reserved.

    8. con dietas suplementadas con Cromo-L-metionina

      Directory of Open Access Journals (Sweden)

      Ram\\u00F3n Garc\\u00EDa-Castillo

      2006-01-01

      Full Text Available Un total de 48 cerdos (Sus scrofa domesticus; 24 machos castrados y 24 hembras cruzados (Yorkshire, Hampshire, Duroc y Landrace de 3,5 a 4,0 meses de edad y 60,0 ± 5,0 kg PV en finalización. Se alimentaron con dietas isoproteícas (14,5 % PC e isoenergéticas (3.400 kcal EM/kg de MS, adicionadas con Cr-L-metionina (MiCroPlex® (0, 200, 400 y 600 ppb. El experimento tuvo una duración de 45 días y se realizó de agosto a noviembre del 2002 en las instalaciones de la Universidad Autónoma Agraria Antonio Narro, localizada en Saltillo, Coahuila, México. Al tener los animales aproximadamente 95 kg PV, se tomó muestra de 15 ml de sangre por cada animal para determinar la concentración de glucosa, ácido úrico, creatinina, urea, proteinas totales y colesterol. Se aplicó un diseño completamente al azar con arreglo factorial 2 x 4; dos para el factor sexo y cuatro para nivel de cromo. Los metabolitos en suero no fueron afectados (P>0,05 por el factor sexo. La glucosa en suero disminuyó (P<0,05 y el colesterol incrementó (P<0,05 con cromo en la dieta. Se concluye que el Cr incrementa el metabolismo de glucosa y disminuye el de colesterol, con lo cual puede haber energía disponible para síntesis de proteína la cual es necesaria para el crecimiento de los animales

    9. Negotiating Colonial Korean Cinema in the Japanese Empire: From the Silent Era to the Talkies, 1923-1939

      OpenAIRE

      Chonghwa Chung

      2012-01-01

      This article examines what I call a “system of cooperation” (K. hyŏp’ŏp, J. kyōgyō, 協業) in the colonial Korean film industry from 1923, when silent films appeared, to the late 1930s, when colonial cinema was restructured within an imperial wartime system. In other words, this article examines the interworking of colonial Korean and imperial Japanese cinema from Yun Hae-dong’s “colonial modern” perspective in order to go beyond the long established lens on colonial Korean film and film histori...

    10. The effects of whispering-to-oneself and silent reading on text memory and comprehension in children

      OpenAIRE

      Matsumi, Norio; Furumoto, Yumi; Mitsuke, Ai

      2005-01-01

      An experiment was carried out to investigate the effects of whispering-to-oneself reading on text memory and comprehension in children (6th grade). A2×2 factorial design was used in the experiment: the first independent variable was whispering-to-oneself or silent reading, the second was large- or small-working memory span which were measured by the reading span test (RST). Four aspects of the text memory and comprehension were observed as dependent variables: text memory both on the literal ...

    11. Implementation of IEC Generic Models of Type 1 Wind Turbine Generator in DIgSILENT PowerFactory

      Institute of Scientific and Technical Information of China (English)

      Haoran ZHAO; Qiuwei WU; Ioannis MARGARIS; Poul S(O)RENSEN

      2013-01-01

      The implementation method for the International Electrotechnical Commission (IEC) generic models of Type 1 wind turbine generator (WTG) in DIgSILENT PowerFactory is presented.The following items are described,i.e.model structure,model blocks and how to implement these blocks in the PowerFactory environment.Case studies under both normal and fault conditions are done with the implemented IEC generic models of Type 1 WTG,and dynamic responses are captured and analyzed.The case study results show that the IEC generic models of Type 1 WTG can correctly represent the performances of Type 1 WTG under both normal and fault conditions.

    12. Scintigraphic diagnosis of silent aspiration following double-sided lung transplantation; Szintigraphischer Nachweis einer stillen Aspiration nach beidseitiger Lungentransplantation

      Energy Technology Data Exchange (ETDEWEB)

      Toenshoff, G. [Kiel Univ. (Germany). Klinik fuer Nuklearmedizin; Stock, U. [Kiel Univ. (Germany). Klinik fuer Herz- und Gefaesschirurgie; Bohuslavizki, K.H. [Kiel Univ. (Germany). Klinik fuer Nuklearmedizin; Brenner, W. [Kiel Univ. (Germany). Klinik fuer Nuklearmedizin; Costard-Jaeckle, A. [Kiel Univ. (Germany). Klinik fuer Herz- und Gefaesschirurgie; Cremer, J. [Kiel Univ. (Germany). Klinik fuer Herz- und Gefaesschirurgie; Clausen, M. [Kiel Univ. (Germany). Klinik fuer Nuklearmedizin

      1996-08-01

      We present a case of a 25 year old patient who underwent double-sided lung transplantation and suffered from recurrent pneumonia. Silent aspiration was suspected clinically. Aspiration was proved by scintigraphy enabling to discriminate between direct oro-pulmonal aspiration and aspiration after gastro-esophageal reflux. (orig.) [Deutsch] Vorgestellt wird der Fall einer 25jaehrigen Patientin nach beidseitiger Lungentransplantation und rezidivierenden Pneumonien. Klinisch bestand der Verdacht auf eine stille Aspiration. Szintigraphisch gelang sowohl der Aspirationsnachweis als auch eine Differenzierung hinsichtlich der Genese: Direkte oro-pulmonale Aspiration versus Aspiration nach gastrooesophagealem Reflux. (orig.)

    13. Generational differences in complementary and alternative medicine (CAM) use in the context of chronic diseases and pain: baby boomers versus the silent generation.

      Science.gov (United States)

      Ho, Tiffany F; Rowland-Seymour, Anastasia; Frankel, Eitan S; Li, Susan Q; Mao, Jun J

      2014-01-01

      More people are supplementing conventional medicine with complementary and alternative medicine (CAM), but studies have not compared CAM use between baby boomers (adults born from 1946 to 1964) and the so-called silent generation (born from 1925 to 1945). This study compares CAM usage between baby boomers (n = 7734) and the silent generation (n = 4682) through secondary analyses of the 2007 National Health Interview Survey data. The analysis also compares chronic disease and pain status. Multivariate logistic regression models were developed to identify generational differences. Although the silent generation reported twice as many chronic disease (51.3% vs 26.1%; P painful conditions (56.1% vs 52.2%; P CAM within the past year (43.1% vs 35.4%; P CAM than adults from the silent generation. Chronic pain status was independently associated with greater CAM use (adjusted odds ratio, 2.26; 95% confidence interval, 2.03-2.52). Baby boomers reported significantly higher rates of CAM use than the silent generation for both chronic diseases and painful conditions. Family physicians caring for the aging population must use patient-centered communication about the risks/benefits of CAM, which is necessary to promote effective coping with chronic illnesses and pain. © Copyright 2014 by the American Board of Family Medicine.

    14. Population based prevalence of high blood pressure among adults in Addis Ababa: uncovering a silent epidemic.

      Science.gov (United States)

      Tesfaye, Fikru; Byass, Peter; Wall, Stig

      2009-08-23

      The prevention and control of high blood pressure or other cardiovascular diseases has not received due attention in many developing countries. This study aims to describe the epidemiology of high blood pressure among adults in Addis Ababa, so as to inform policy and lay the ground for surveillance interventions. Addis Ababa is the largest urban centre and national capital of Ethiopia, hosting about 25% of the urban population in the country. A probabilistic sample of adult males and females, 25-64 years of age residing in Addis Ababa city participated in structured interviews and physical measurements. We employed a population based, cross sectional survey, using the World Health Organization instrument for stepwise surveillance (STEPS) of chronic disease risk factors. Data on selected socio-demographic characteristics and lifestyle behaviours, including physical activity, as well as physical measurements such as weight, height, waist and hip circumference, and blood pressure were collected through standardized procedures. Multiple linear regression analysis was performed to estimate the coefficient of variability of blood pressure due to selected socio-demographic and behavioural characteristics, and physical measurements. A total of 3713 adults participated in the study. About 20% of males and 38% of females were overweight (body-mass-index > or = 25 kg/m2), with 10.8 (9.49, 12.11)% of the females being obese (body-mass-index > or = 30 kg/m2). Similarly, 17% of the males and 31% of the females were classified as having low level of total physical activity. The age-adjusted prevalence (95% confidence interval) of high blood pressure, defined as systolic blood pressure (SBP) > or = 140 mmHg (millimetres of mercury) or diastolic blood pressure (DBP) > or = 90 mmHg or reported use of anti-hypertensive medication, was 31.5% (29.0, 33.9) among males and 28.9% (26.8, 30.9) among females. High blood pressure is widely prevalent in Addis Ababa and may represent a silent

    15. Sounds from seeing silent motion: Who hears them, and what looks loudest?

      Science.gov (United States)

      Fassnidge, Christopher J; Freeman, Elliot D

      2018-03-09

      Some people hear what they see: car indicator lights, flashing neon shop signs, and people's movements as they walk may all trigger an auditory sensation, which we call the visual-evoked auditory response (vEAR or 'visual ear'). We have conducted the first large-scale online survey (N > 4000) of this little-known phenomenon. We analysed the prevalence of vEAR, what induces it, and what other traits are associated with it. We assessed prevalence by asking whether respondents had previously experienced vEAR. Participants then rated silent videos for vividness of evoked auditory sensations, and answered additional trait questions. Prevalence appeared higher relative to other typical synaesthesias. Prior awareness and video ratings were associated with greater frequency of other synaesthesias, including flashes evoked by sounds, and musical imagery. Higher-rated videos often depicted meaningful events that predicted sounds (e.g., collisions). However, even videos containing abstract flickering or moving patterns could also elicit higher ratings, despite having no predictable association with sounds. Such videos had higher levels of raw 'motion energy' (ME), which we quantified using a simple computational model of motion processing in early visual cortex. Critically, only respondents reporting prior awareness of vEAR tended to show a positive correlation between video ratings and ME. This specific sensitivity to ME suggests that in vEAR, signals from visual motion processing may affect audition relatively directly without requiring higher-level interpretative processes. Our other findings challenge the popular assumption that individuals with synaesthesia are rare and have ideosyncratic patterns of brain hyper-connectivity. Instead, our findings of apparently high prevalence and broad associations with other synaesthesias and traits are jointly consistent with a common dependence on normal variations in physiological mechanisms of disinhibition or excitability of

    16. Resveratrol Protects Against Pulmonary Arterial Hypertension in Rats via Activation of Silent Information Regulator 1

      Directory of Open Access Journals (Sweden)

      Lei Yu

      2017-05-01

      Full Text Available Background/Objectives: The polyphenol resveratrol (Rev has been found to exhibit various beneficial effects including prevention of pulmonary arterial hypertension (PAH. The present study was designed to investigate the action and potential mechanism of Rev on PAH, focusing on the role of SIRT1 (Silent Information Regulator 1 in apoptosis of pulmonary artery smooth muscle cells (PASMCs. Methods: PAH rats were established by exposure to hypoxia for 21 days. Rev and SRT1720 (a selective SIRT1 activator were used to reverse PAH by gavaging rats. PASMCs were confronted with hypoxia for 24 h or 48 h and were then treated with Rev or SRT1720 in vitro. Western blot was performed to detect the protein expression of SIRT1. CCK-8 and scratch wound experiments were carried out to verify cell proliferation. In addition, the TUNEL positive assay and flow cytometry assay were used to measure PASMC apoptosis. Mitochondrial permeability transition (mPT was identified by confocal microscopy. Right ventricular systolic pressure (RVSP was determined with a Gould pressure transducer, and right ventricular hypertrophy (RVH was determined by weighing the cardiac muscle. Results: We demonstrated that Rev could reverse the remodelling of the pulmonary vasculature, thus contributing to alleviating the severity of PAH. Down-regulation of SIRT1 was observed in PAH, but administration of Rev had no obvious effect on the protein expression of SIRT1. In addition, Rev could induce mitochondrial swelling and nuclear pyknosis, leading to small, dense, and dysmorphic mitochondria in rats exposed to hypoxia alone. Rev treatment inhibited PASMC proliferation in a dose-dependent manner in vitro. Incubation with SRT1720, a specific activator of SIRT1, significantly retarded PASMC proliferation and promoted PASMC apoptosis in vitro. The mechanism could be associated with inducing mPT damage in PASMCs. Rev and SRT1720 treatment mitigated RVSP and reduced RVH. Conclusion: Rev produced

    17. Contribution of silent mutations to thermal adaptation of RNA bacteriophage Qβ.

      Science.gov (United States)

      Kashiwagi, Akiko; Sugawara, Ryu; Sano Tsushima, Fumie; Kumagai, Tomofumi; Yomo, Tetsuya

      2014-10-01

      Changes in protein function and other biological properties, such as RNA structure, are crucial for adaptation of organisms to novel or inhibitory environments. To investigate how mutations that do not alter amino acid sequence may be positively selected, we performed a thermal adaptation experiment using the single-stranded RNA bacteriophage Qβ in which the culture temperature was increased from 37.2°C to 41.2°C and finally to an inhibitory temperature of 43.6°C in a stepwise manner in three independent lines. Whole-genome analysis revealed 31 mutations, including 14 mutations that did not result in amino acid sequence alterations, in this thermal adaptation. Eight of the 31 mutations were observed in all three lines. Reconstruction and fitness analyses of Qβ strains containing only mutations observed in all three lines indicated that five mutations that did not result in amino acid sequence changes but increased the amplification ratio appeared in the course of adaptation to growth at 41.2°C. Moreover, these mutations provided a suitable genetic background for subsequent mutations, altering the fitness contribution from deleterious to beneficial. These results clearly showed that mutations that do not alter the amino acid sequence play important roles in adaptation of this single-stranded RNA virus to elevated temperature. Recent studies using whole-genome analysis technology suggested the importance of mutations that do not alter the amino acid sequence for adaptation of organisms to novel environmental conditions. It is necessary to investigate how these mutations may be positively selected and to determine to what degree such mutations that do not alter amino acid sequences contribute to adaptive evolution. Here, we report the roles of these silent mutations in thermal adaptation of RNA bacteriophage Qβ based on experimental evolution during which Qβ showed adaptation to growth at an inhibitory temperature. Intriguingly, four synonymous mutations and

    18. Silent changes of tuberculosis in Iran (2005-2015: A joinpoint regression analysis

      Directory of Open Access Journals (Sweden)

      Abolfazl Marvi

      2017-01-01

      Full Text Available Introduction and Aim: Tuberculosis (TB poses a severe risk to public health through the world but excessively distresses low-income nations. The aim of this study is to analyze silent changes of TB in Iran (2005–2015: A joinpoint regression analysis. Materials and Methods: This is a trend study conducted on all patients (n = 70 that register in control disease center of Joibar (one of coastal cities and tourism destination in Northern Iran which was recognized as an independent town since 1998 during 2005–2015. The characteristics of patients imported to the SPSS 19 and variation in incidence rate of different forms of pulmonary TB (PTB (PTB+ or PTB– and extra-PTB (EPTB/year was analyzed. Variation in incidence rate of TB for male and female groups and different age groups (0–14, 15–24, 25–34, 35–44, 45–54, 55–64, and above 65 years was analyzed, variation in trend of this diseases for different groups was compared in intended years, and also, variation in incidence rate of TB was analyzed by Joinpoint Regression Software. Results: The total number of TB was 70 cases during 2005–2015. The mean age of patients was 42.31 ± 21.26 years and median age was 40 years. About 71.4% of patients were PTB (55.7% for with PTB+ and 15.7% with PTB– and rest of them (28.4% were EPTB. In regard to classification of cases, 97.1% of them were new cases, 1.45% of them were relapsed cases, and 1.45% of them imported cases. In addition, history of hospitalization due to TB was observed in 44.3%. Conclusion: Despite recent developments of governmental health-care system in Iran and proper access to it and considering this fact that identification of TB cases with passive surveillance is possible. Hence, developing certain programs for sensitization of the covered population is essential.

    19. Accidente cerebrovascular isquémico asociado con ablación por radiofrecuencia de reentrada nodal Ischemic stroke associated with radio frequency ablation for nodal reentry

      Directory of Open Access Journals (Sweden)

      Juan C Díaz Martínez

      2010-04-01

      Full Text Available La taquicardia por reentrada nodal es la causa más común de taquicardia supraventricular paroxística; en aquellos pacientes en quienes el manejo farmacológico no es efectivo o deseado la ablación por radiofrecuencia es un excelente método terapéutico dada su alta tasa de curación. Aunque en términos generales dichos procedimientos son rápidos y seguros, se han descrito varias complicaciones entre las que sobresale el accidente cerebrovascular isquémico. Se presenta el caso de una paciente de 41 años con episodios de taquicardia por reentrada nodal a repetición, que fue llevada a ablación por radiofrecuencia. En el post-operatorio inmediato se evidenció déficit neurológico focal con isquemia en el territorio de la arteria cerebral media derecha, tras lo cual se realizó angiografía con intento de angioplastia y abxicimab y posteriormente infusión local de activador de plasminógeno tisular (rtPA con adecuado resultado clínico y angiográfico.Atrioventricular nodal reentry tachycardia is the most common type of paroxismal supraventricular tachycardia. In those patients in whom drug therapy is not effective or not desired, radio frequency ablation is an excellent therapeutic method. Although overall these procedures are fast and safe, several complications among which ischemic stroke stands out, have been reported. We present the case of a 41 year old female patient with repetitive episodes of tachycardia due to nodal reentry who was treated with radiofrequency ablation. Immediately after the procedure she presented focal neurologic deficit consistent with ischemic stroke in the right medial cerebral artery territory. Angiography with angioplastia and abxicimab was performed and then tissue plasminogen activator (rtPA was locally infused, with appropriate clinical and angiographic outcome.

    20. Riesgo de ictus isquémico en niños con Sβ talasemia. Estudio con Doppler transcraneal Risks of ischemic stroke in children suffering Sβ-thalassemia. Transcranial Doppler study

      Directory of Open Access Journals (Sweden)

      Claudio Enrique Scherle-Matamoros

      2012-06-01

      Full Text Available En niños con anemia por células falciformes, el riesgo de ictus isquémico varía según el genotipo de la hemoglobinopatía. En estos casos, la determinación de la velocidad de flujo sanguíneo mediante Doppler transcraneal (DTC puede predecir la ocurrencia de isquemia cerebral. Con el objetivo de describir las características del DTC en la Sβ talasemia, se estudiaron 32 enfermos menores de 18 años atendidos en el Instituto de Hematología e Inmunología y remitidos para su evaluación con ultrasonido. La edad media de los niños fue de 10,5 años. Se estudió la misma cantidad de enfermos con cada genotipo Sβ; solamente en un paciente la ventana temporal no fue útil. En el 97 % de los enfermos la velocidad media de flujo en las arterias cerebrales medias era inferior a 170 cm/s y solo en un niño estaban en el rango del grupo condicional. Se registraron asimetrías interhemisféricas en la velocidad media de flujo de las arterias cerebrales anteriores en el 29 % de los casos; en el 19,6 % en las arterias cerebrales medias; y en el 6,4 % en las carótidas internas extracraneales. Los niveles más altos de velocidad media de flujo se registraron en los enfermos con Sβ0 talasemia y en las arterias cerebrales medias. Existió una correlación inversa entre la edad y los niveles de hemoglobina con la velocidad de flujo de los 3 vasos estudiados. El riesgo de ictus isquémico en la Sβ talasemia es bajo, sin diferencia entre los 2 genotipos evaluados.In children with sickle cell anemia, the risk of ischemic stroke varies according to genotype of hemoglobinopathy. In these cases, determining the velocity of blood flow by transcranial Doppler (TCD can predict the occurrence of cerebral ischemia. In order to describe the characteristics of DTC in Sβ thalassemia, we studied 32 patients younger than 18 treated at the Institute of Hematology and Immunology, who were referred for ultrasound assessment. The age rate of children was 10.5 years old

    1. Recubrimiento de acero con polidopamina

      OpenAIRE

      Carrasco Rodríguez, Javier

      2013-01-01

      Se ha obtenido recubrimientos de polidopamina en acero mecánicamente resistentes y con tiempos de obtención relativamente pequeños a través de la polimerización de la dopamina bajo diferentes condiciones.

    2. Ketone bodies metabolism during ischemic and reperfusion brain injuries following bilateral occlusion of common carotid arteries in rats Metabolismo dos corpos cetônicos durante as lesões de isquemia e reperfusão cerebrais após oclusão bilateral das artérias carótidas comuns em ratos

      Directory of Open Access Journals (Sweden)

      Mário Henrique Girão Faria

      2007-04-01

      Full Text Available PURPOSE: To evaluate the in vivo alterations on ketone bodies metabolism after cerebral ischemia/reperfusion through an experimental model of brain ischemia induced by simple occlusion of common carotid arteries (CCAs in Wistar rats. METHODS: Forty-eight male Wistar rats were randomly distributed on two groups (S - Sham; T - Test and further redistributed into four times sets of study. After bilateral occlusion of CCAs for 30min, the animals of group T were allowed reperfusion for 0, 5, 10 and 15min. Samples of cerebral tissue and systemic arterial blood were collected and the metabolites acetoacetate (ACT and beta-hydroxybutyrate (BHB were determined. RESULTS: Cerebral ACT and BHB levels increased significantly in Group T after 30min of carotid occlusion (time 0. The highest brain ketone bodies (ACT+BHB concentration was verified at 5min of reperfusion, decreasing after 10min of recirculation. Systemic ketone bodies levels increased similarly between test and sham groups. Group S demonstrated a significant increase in cerebral and systemic ACT and BHB concentrations mainly after 40-45min of study. CONCLUSIONS: The partial transient acute global brain ischemia induced by the bilateral carotid occlusion in Wistar rats triggered ketogenesis probably due to a central stimulation of catecholamine secretion. There was an increased cerebral uptake of ketone bodies following brain ischemia, reaffirming these metabolites as alternative energy substrates under conditions of cerebral metabolic stress as well as its potential role on neuroprotection. The greatest changes in ketone bodies metabolism were verified at initial minutes of recirculation as a result of the reperfusion injury phenomenon.OBJETIVO: Avaliar as alterações in vivo no metabolismo dos corpos cetônicos após isquemia/reperfusão cerebral através de um modelo experimental de isquemia cerebral induzido pela simples oclusão das artérias carótidas comuns (CCAs em ratos Wistar. M

    3. Ischemia-reperfusion histopathology alterations of the rabbit intestinal wall with and without ischemic preconditioning Alterações histopatológicas da parede intestinal de coelhos na isquemia-reperfusão com e sem precondicionamento isquêmico

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      Otoni Moreira Gomes

      2011-08-01

      Full Text Available PURPOSE: To evaluate the histopathology alterations of the intestinal mucosa of rabbits submitted to mesenteric artery ischemia and reperfusion with and without ischemic preconditioning. METHODS: Two groups of ten male New Zealand white rabbits body (weight 2.2-3.0, average 2.5 kg. For mesenteric ischemia induction in all animals the small bowel and mesentery were cut 30cm and 60cm far from the gastroduodenal pyloric transition before the proximal mesenteric artery occlusion. In the Group 1 animals, the proximal mesenteric artery was occluded for 45 min with an atraumatic vascular clamp, followed by reperfusion for 30 min. In the Group 2 the 45 min ischemic phase was preceded by three cycles of ischemia (2 minutes each alternated with three cycles of reperfusion (2 minutes each. For istopathology study small bowel biopsies were obtained before ischemia (control, after 45 min of mesenteric ischemia and at 30 min. of mesenteric artery reperfusion. RESULTS: In the Group I animals, the followings histopathology grade results were observed: t1, mean 2,8; t2, mean 3,3. Using the Kruskal-Wallis non-parameter test, differences between t0 and t1 and t0 and t2 were significants (p0.05. In the Group 2 animals histopathology grade results were: t1 mean 2,6 and t2, mean 2,1. Differences between t0 and t1, t0 and t2 were significant (p0.05 between results of t1 in both groups but histopathology injury observed in Group 1 t2 biopsies were higher (pOBJETIVO: Avaliar as alterações histopatológicas da mucosa intestinal de coelhos submetidos a isquemia-reperfusão com e sem precondicionamento isquêmicol. MÉTODOS: Foram estudados dois grupos de dez coelhos Nova Zelândia machos com pesos variáveis entre 2,2 e 3,0 kg (média de 2,5 kg de peso corpóreo. Para indução da isquemia, em todos os animais, o intestino delgado e o mesentério foram seccionados 30 cm e 60 cm após a transição pilórica gastroduodenal, antes da oclusão da artéria mesent

    4. Ischemia-reperfusion histopathology alterations of the rabbit intestinal wall with and without exclusion of the collateral mesenteric circulation supply Alterações histopatológicas da parede intestinal de coelhos na isquemia-reperfusão com e sem exclusão da circulação mesentérica colateral

      Directory of Open Access Journals (Sweden)

      Otoni Moreira Gomes

      2010-08-01

      Full Text Available PURPOSE: To evaluate the histopathology alterations of the intestinal mucosa of rabbits submitted to different times of mesenteric artery ischemia and reperfusion with and without celiac artery collateral circulation supply. METHODS: Two groups of eight male New Zealand white rabbits (weight 2.2-3.5 kg were used in this study. In the Group 1 animals, the proximal mesenteric artery was occluded for 60 min with an atraumatic vascular clamp, followed by reperfusion for 60 min. In the Group 2 animals the small bowel and mesentery were cut 30cm and 60cm far from the gastroduodenal pyloric transition before the proximal mesenteric artery occlusion. Small bowel biopsies were obtained before ischemia (control, after 30 min and 60 min of mesenteric ischemia and at 30 and 60 min. of mesenteric artery reperfusion. RESULTS: In the Group I animals, the followings histopathology grade results were observed: t1, mean 0.4 + 0.29; t2, mean 1.9 ± 0.38; t3, 1.9 ± 0.33; t4, 1.2 ± 0.36 and t5, 1.2 ± 0.32. Differences between t0 and t2 and between t3 and t4 were statistically significant (p0.5. In the Group II animals, it was observed: t1, mean 1.6 ± 0.33; t2, 2.4 ± 0.36; t3, 3.0 ± 0.35; t4 3.4 ± 0.31; t5, 3 ± 031. Differences between t0 and t1, t1 and t2, and t2 and t3 were significant (pOBJETIVO: Avaliar as alterações histopatológicas da mucosa intestinal de coelhos submetidos à isquemia-reperfusão com e sem exclusão da circulação mesentérica colateral. MÉTODOS: Foram estudados dois grupos de oito coelhos Nova Zelândia machos com pesos variáveis entre 2,2 e 3,5 kg de peso corpóreo. Nos animais do Grupo 1, a artéria mesentérica proximal foi ocluida por pinçamento atraumático durante 60 min, seguido de reperfusão por 60 min. No Grupo 2 o intestino delgado e o mesentério foram seccionados 30 cm e 60 após a transição pilórica gastroduodenal antes da oclusão da artéria mesentérica cranial. Biópsias da parede intestinal foram obtidas

    5. The Incidence and the Risk Factors of Silent Embolic Cerebral Infarction After Coronary Angiography and Percutaneous Coronary Interventions.

      Science.gov (United States)

      Deveci, Onur Sinan; Celik, Aziz Inan; Ikikardes, Firat; Ozmen, Caglar; Caglıyan, Caglar Emre; Deniz, Ali; Bicakci, Kenan; Bicakci, Sebnem; Evlice, Ahmet; Demir, Turgay; Kanadasi, Mehmet; Demir, Mesut; Demirtas, Mustafa

      2016-05-01

      Silent embolic cerebral infarction (SECI) is a major complication of coronary angiography (CAG) and percutaneous coronary intervention (PCI). Patients with stable coronary artery disease (CAD) who underwent CAG with or without PCI were recruited. Cerebral diffusion-weighted magnetic resonance imaging was performed for SECI within 24 hours. Clinical and angiographic characteristics were compared between patients with and without SECI. Silent embolic cerebral infarction occurred in 12 (12%) of the 101 patients. Age, total cholesterol, SYNTAX score (SS), and coronary artery bypass history were greater in the SECI(+) group (65 ± 10 vs 58 ± 11 years,P= .037; 223 ± 85 vs 173 ± 80 mg/dL,P= .048; 30.1 ± 2 vs 15 ± 3,PSECI was more common in the PCI group (8/24 vs 4/77,P= .01). On subanalysis, the SS was significantly higher in the SECI(+) patients in both the CAG and the PCI groups (29.3 ± 1.9 vs 15 ± 3,PSECI after CAG and PCI increases with the complexity of CAD (represented by the SS). The SS is a predictor of the risk of SECI, a complication that should be considered more often after CAG. © The Author(s) 2015.

    6. Santiago, una ciudad con temor

      Directory of Open Access Journals (Sweden)

      Enrique Oviedo S.

      1999-04-01

      Full Text Available El objetivo general de este artículo es evaluar los efectos de la inseguridad ciudadana en el uso del espacio público. Dicha evaluación exige analizar dos relaciones que se establecen en el ámbito de la violencia: la relación entre victimización y percepción de inseguridad; y la que se establece entre actitudes sociales y resolución pacífica de conflictos nacionales. Para ello, se analizaron las variables victimización, percepción de inseguridad, uso del espacio físico, actitudes hacia el sistema institucional político y social y hacia la resolución de conflictos nacionales, y las posibles relaciones entre ellas. Los datos para realizar el estudio se obtuvieron por medio de una encuesta que se llevó a cabo con 1 200 personas de 18 y 70 años de edad residentes en la ciudad de Santiago. Los resultados indican que Santiago es una ciudad de habitantes con temor y que el aumento de la percepción de inseguridad de sus habitantes contrasta con el hecho de que las tasas de victimización se hayan mantenido, más o menos, constantes en los años que precedieron a la encuesta. El temor se relaciona con el abandono del espacio público físico y sociopolítico, así como con el refugio en los espacios y la vida privados. La actitud de resolver los conflictos por medios no pacíficos es frecuente y se asocia en mayor medida con la inseguridad, la actitud negativa hacia la democracia y la falta de expectativas sobre el futuro del país. Los resultados de este estudio respaldan la idea de que para superar el temor la gente tiende a adaptarse a la realidad adoptando una postura conformista, homogeneizando las creencias y los comportamientos, y sobreestimando la fuerza como medio para resolver las diferencias.

    7. Santiago, una ciudad con temor

      Directory of Open Access Journals (Sweden)

      Oviedo S. Enrique

      1999-01-01

      Full Text Available El objetivo general de este artículo es evaluar los efectos de la inseguridad ciudadana en el uso del espacio público. Dicha evaluación exige analizar dos relaciones que se establecen en el ámbito de la violencia: la relación entre victimización y percepción de inseguridad; y la que se establece entre actitudes sociales y resolución pacífica de conflictos nacionales. Para ello, se analizaron las variables victimización, percepción de inseguridad, uso del espacio físico, actitudes hacia el sistema institucional político y social y hacia la resolución de conflictos nacionales, y las posibles relaciones entre ellas. Los datos para realizar el estudio se obtuvieron por medio de una encuesta que se llevó a cabo con 1 200 personas de 18 y 70 años de edad residentes en la ciudad de Santiago. Los resultados indican que Santiago es una ciudad de habitantes con temor y que el aumento de la percepción de inseguridad de sus habitantes contrasta con el hecho de que las tasas de victimización se hayan mantenido, más o menos, constantes en los años que precedieron a la encuesta. El temor se relaciona con el abandono del espacio público físico y sociopolítico, así como con el refugio en los espacios y la vida privados. La actitud de resolver los conflictos por medios no pacíficos es frecuente y se asocia en mayor medida con la inseguridad, la actitud negativa hacia la democracia y la falta de expectativas sobre el futuro del país. Los resultados de este estudio respaldan la idea de que para superar el temor la gente tiende a adaptarse a la realidad adoptando una postura conformista, homogeneizando las creencias y los comportamientos, y sobreestimando la fuerza como medio para resolver las diferencias.

    8. La violencia de pareja: Un enemigo silencioso/Partner violence: a silent enemy

      OpenAIRE

      Francisco Javier Batiza Álvarez

      2017-01-01

      La violencia en la pareja es un fenómeno silencioso que afecta de diferentes formas a quien la padece, puede ser física, psicológica, intimidatoria, sexual o económica. El problema se puede presentar en el noviazgo o en el matrimonio, empero, son los jóvenes que viven relaciones de noviazgo quienes se están convirtiendo en un grupo vulnerable, insertándose en la espiral de la violencia. Lamentablemente en muchas ocasiones parece imposible salir de un ciclo que comienza con pequeñas bromas hi...

    9. Fibromyalgia, mood disorders, and intense creative energy: A1AT polymorphisms are not always silent.

      Science.gov (United States)

      Schmechel, Donald E; Edwards, Christopher L

      2012-12-01

      Persons with single copies of common alpha-1-antitrypsin polymorphisms such as S and Z are often considered "silent carriers". Published evidence however supports a complex behavioral phenotype or trait - intense creative energy ("ICE")-associated with A1AT polymorphisms. We now confirm that phenotype and present an association of fibromyalgia syndrome (FMS) and A1AT in a consecutive series of neurological patients. This is a retrospective case control series of 3176 consecutive patients presenting to Duke University Memory Clinic (747 patients) and to regional community-based Caldwell Hospital Neurology and Memory center (2429 patients). Work-up included medical history and examination, psychological evaluation, and genetic analysis. Chronic widespread pain (CWP) or FMS were diagnosed according to clinical guidelines, mostly as secondary diagnoses. Neurological patients carrying A1AT polymorphisms were common (ca 16% prevalence) and carriers had significantly higher use of inhaler and anxiolytic medications. Patients with ICE phenotype had a significantly higher proportion of A1AT polymorphisms (42%) compared to non-ICE patients (13%). Presence of CWP or FMS was common (14-22%) with average age at presentation of 56 years old and mostly female gender (82%). Patients with CWP/FMS had again significantly higher proportion of A1AT polymorphisms (38%) compared to other neurological patients (13%). Patients with anxiety disorders, bipolar I or bipolar II disorders or PTSD also had increased proportion of A1AT polymorphisms and significant overlap with ICE and FMS phenotype. Significant reductions in CWP/FMS prevalence are seen in apolipoprotein E4 carriers and methylene tetrahydrofolate reductase (MTHFR) mutation homozygotes. Since ICE phenotype is reported as a lifelong behavioral attribute, the presumption is that A1AT carriers have fundamental differences in brain development and inflammatory response. In support of this concept is finding those persons reporting a

    10. La violencia de pareja: Un enemigo silencioso/Partner violence: a silent enemy

      Directory of Open Access Journals (Sweden)

      Francisco Javier Batiza Álvarez

      2017-01-01

      Full Text Available La violencia en la pareja es un fenómeno silencioso que afecta de diferentes formas a quien la padece, puede ser física, psicológica, intimidatoria, sexual o económica. El problema se puede presentar en el noviazgo o en el matrimonio, empero, son los jóvenes que viven relaciones de noviazgo quienes se están convirtiendo en un grupo vulnerable, insertándose en la espiral de la violencia. Lamentablemente en muchas ocasiones parece imposible salir de un ciclo que comienza con pequeñas bromas hirientes y puede culminar con la muerte de una persona; ya no solo se debe hablar de violencia del hombre contra la mujer, también se debe comenzar a observar la violencia de la mujer contra el hombre o la violencia de parejas que están conformadas por hombre-hombre o mujer-mujer. La importancia que se le debe dar al fenómeno de la violencia de pareja debe ser mayor de la que tiene actualmente, pues si bien es cierto que se ha atacado este fenómeno, también es cierto que existe mucha cifra negra sobre el mismo y los grupos vulnerables que lo padecen cada día son más.

    11. pacientes con insuficiencia renal terminal

      Directory of Open Access Journals (Sweden)

      Karen Herrera Herrera

      2011-01-01

      Full Text Available La presente investigación fundamenta en la clínica psicoanalítica el estudio de dos casos de tres personas diagnosticadas con IRT que reciben tratamiento de hemodiálisis, en razón a que dadas las características y el aumento de los reportes que se presentan, ya esto se considera un problema de salud pública. El objetivo principal es describir las características dinámicas del proceso de duelo en pacientes con IRT en un centro de terapia renal de la ciudad de Cartagena. El procedimiento metodológico empleó un diseño de tipo cualitativo; la investigación se desarrolló con un diseño clínico mediante el estudio de casos, y fundamentada en la hermenéutica psicoanalítica. Todo esto respaldado en la historia clínica, la entrevista semiestructurada individual y familiar, los test proyectivos, test del dibujo de la figura humana Machover y TAT de Murray, para la debida integración de los análisis. Se concluye que predominan funciones fallidas de los progenitores y que son individuos provenientes de familias psicosomáticas, que utilizan la enfermedad para obtener un beneficio secundario.

    12. con bajo peso al nacer

      Directory of Open Access Journals (Sweden)

      Adriana Mora Antó

      2005-01-01

      Full Text Available Esta investigación dio cuenta de la relación entre el estilo de funcionamiento familiar, los patrones de crianza y las edades de desarrollo evolutivo en niños, nacidos con bajo peso. El estudio descriptivo correlacional se realizó con 41 niños y sus madres, aplicándose cuestionarios sobre funcionamiento familiar, prácticas de crianza y desarrollo infantil. Los resultados señalaron la existencia de un funcionamiento familiar caracterizado por una cohesión amalgamada y una adaptabilidad caótica, una disciplina complaciente, falta de control y de límites claros en la díada madre-hijo. Se trataba de familias monoparentales, donde la temprana edad de concepción, el madresolterismo y el apoyo de la familia extensa eran constantes. Las edades evolutivas registradas indicaron un desarrollo inferior a la edad cronológica, en la mayor parte de los casos; sin embargo, éstas tendieron a ser superiores al compararlas con la edades reales de los infantes. No se encontró una correlación estadísticamente significativa entre la edad de desarrollo y los diferentes factores del funcionamiento familiar para algunos de los rangos de edad considerados; sin embargo, no se lo descartó por completo, especialmente en lo referente al optimismo familiar

    13. Regional cerebral blood flow and periventricular hyperintensity in silent cerebral infarction. Comparison with multi-infarct dementia

      International Nuclear Information System (INIS)

      Koshi, Yasuhiko; Kitamura, Shin; Nagazumi, Atushi; Tsuganesawa, Toshikazu; Terashi, Akiro

      1996-01-01

      In order to investigate relationship between regional cerebral blood flow (rCBF) and the white matter lesions on MRI in silent cerebral infarction, we quantitatively measured rCBF by 123 I-IMP autoradiography method (IMP ARG method) and single photon emission tomography (SPECT) in 36 patients with silent cerebral infarction (SCI group), 22 patients with multi-infarct dementia (MID group), and 16 control subjects without periventricular hyperintensity (PVH) and lacunar infarction on MRI (CL group). Regions of interest (ROIs) on rCBF images were set in the frontal (F), temporal (T), parietal (P), occipital (O) cortex, and the cerebral white matter (W). The severity of PVH on MRI T 2 -weighted image was divided into four grades (grade 0-3). Though the frequency of hypertension was significantly higher in SCI group and MID group compared with CL group, no significant difference was seen in the mean age among these three groups. rCBF in the white matter and cerebral cortices except the occipital cortex in SCI group was significantly low compared with CL group (rCBF SCI /rCBF CL : W 0.87, F 0.87, T 0.87, P 0.88, O 0.92). rCBF in the white matter and cerebral cortices, especially in the white matter and frontal cortex, in MID group was significantly low compared with SCI group (rCBF MID /rCBF CL : W 0.69, F 0.71, T 0.74, P 0.75, O 0.81). The mean grade of PVH in MID group was significantly higher than that in SCI group (SCI 1.1 vs MID 2.5). The severity of PVH was significantly correlated with each rCBF in the white matter and cerebral cortices, especially in the white matter and frontal cortex. Our findings suggest that the quantitative measurement of rCBF by IMP ARG method is useful for the follow-up study in the patients with silent cerebral infarction as well as the evaluation of the severity of PVH on MRI. (author)

    14. The Relations among Oral and Silent Reading Fluency and Comprehension in Middle School: Implications for Identification and Instruction of Students with Reading Difficulties

      Science.gov (United States)

      Denton, Carolyn A.; Barth, Amy E.; Fletcher, Jack M.; Wexler, Jade; Vaughn, Sharon; Cirino, Paul T.; Romain, Melissa; Francis, David J.

      2011-01-01

      The purpose of this study was to investigate the relations among oral and silent reading fluency and reading comprehension for students in Grades 6 to 8 (n = 1,421) and the use of fluency scores to identify middle school students who are at risk for failure on a high-stakes reading test. Results indicated moderate positive relations between…

    15. Non invasive evaluation of the coronary atherosclerosis illness in patients with silent ischemia: utility of the SPECT of myocardial perfusion. Electric, angiographic and image correlation

      International Nuclear Information System (INIS)

      Puente B, A.; Roffe G, F.; Aceves C, J.; Gomez A, E.

      2005-01-01

      The objective of the work was to determine the utility of the SPECT (Single Photon Emission Computerized Tomography) of myocardial perfusion for the ischemia detection in asymptomatic patients with Coronary Atherosclerosis Illness. It was concluded that the SPECT of myocardial perfusion has a high sensitivity (97%) for the silent ischemia diagnosis

    16. Major-element geochemistry of the Silent Canyon--Black Mountain peralkaline volcanic centers, northwestern Nevada Test Site: applications to an assessment of renewed volcanism

      International Nuclear Information System (INIS)

      Crowe, B.M.; Sargent, K.A.

      1979-01-01

      The Silent Canyon and Black Mountain volcanic centers are located in the northern part of the Nevada Test Site. The Silent Canyon volcanic center is a buried cauldron complex of Miocene age (13 to 15 m.y.). Black Mountain volcanic center is an elliptical-shaped cauldron complex of late Miocene age. The lavas and tuffs of the two centers comprise a subalkaline-peralkaline association. Rock types range from quartz normative subalkaline trachyte and rhyolite to peralkaline commendite. The Gold Flat Member of the Thirsty Canyon Tuff (Black Mountain) is a pantellerite. The major-element geochemistry of the Black Mountain--Silent Canyon volcanic centers differ in the total range and distribution of SiO 2 , contents, the degree of peralkalinity (molecular Na 2 O + K 2 O > Al 2 O 3 ) and in the values of total iron and alumina through the range of rock types. These differences indicate that the suites were unrelated and evolved from differing magma bodies. The Black Mountain volcanic cycle represents a renewed phase of volcanism following cessation of the Timber Mountain--Silent Canyon volcanic cycles. Consequently, there is a small but numerically incalculable probability of recurrence of Black Mountain-type volcanism within the Nevada Test Site region. This represents a potential risk with respect to deep geologic storage of high-level radioactive waste at the Nevada Test Site

    17. Neuroimaging of language processes: fMRI of silent and overt lexical processing and the promise of multiple process imaging in single brain studies

      International Nuclear Information System (INIS)

      Borowsky, R.; Owen, W.J.; Wile, T.L.; Friesen, C.K.; Martin, J.L.; Sarty, G.E.

      2005-01-01

      To implement and evaluate a multiple-process functional magnetic resonance imaging (fMRI) paradigm designed to effectively and efficiently activate several language-related regions for use with neurosurgical patients. Both overt and covert response conditions were examined. The fMRI experiments compared the traditional silent word-generation condition versus an overt one as they engage frontal language regions (Experiment 1) and silent versus overt semantic association conditions as they engage multiple language processing regions (Experiment 2). In Experiment 1 the overt condition yielded greater magnitude of activation, but not volume of activation, in the left inferior frontal and insular cortices than did the silent condition for most, but not all, participants. Experiment 2 demonstrated that the activation of multiple established language processing regions (ie, orthographic, phonological and semantic) can be achieved in a significant number of participants, particularly under overt semantic association conditions and that such activation varies in predictable ways. The traditional silent response condition cannot be considered as equivalent to the overt response condition during word generation or semantic association. The multiple-process imaging method introduced here was sensitive to processing robust orthographic, phonological, and semantic regions, particularly under the overt response condition. (author)

    18. The "Silent Dog" Method: Analyzing the Impact of Self-Generated Rules when Teaching Different Computer Chains to Boys with Autism

      Science.gov (United States)

      Arntzen, Erik; Halstadtro, Lill-Beathe; Halstadtro, Monica

      2009-01-01

      The purpose of the study was to extend the literature on verbal self-regulation by using the "silent dog" method to evaluate the role of verbal regulation over nonverbal behavior in 2 individuals with autism. Participants were required to talk-aloud while performing functional computer tasks.Then the effects of distracters with increasing demands…

    19. Conversando con...Momoyo Kaijima

      OpenAIRE

      Gómez Alonso, Carlos; Álvarez Isidro, Eva; Torres Barchino, Ana

      2017-01-01

      [ES] Momoyo Kaijima es profesora en la Facultad de Arte y Diseño de la Universidad de Tsukuba en la Prefectura de Ibaraki y profesora visitante en la ETH de Zürich, en Royal Academy of Fine Arts, en Rice School of Architecture y en Harvard GSD. A lo largo de los años, Atelier Bow Wow ha colaborado con Krešimir Rogina, arquitecto de Zagreb y socio de la firma internacional Penezic&Rogina, en la realización del Grožnjan International Summer School of Architecture, siendo Rogina el nexo indispen...

    20. Low-Boom and Low-Drag Optimization of the Twin Engine Version of Silent Supersonic Business Jet

      Science.gov (United States)

      Sato, Koma; Kumano, Takayasu; Yonezawa, Masahito; Yamashita, Hiroshi; Jeong, Shinkyu; Obayashi, Shigeru

      Multi-Objective Optimization has been applied to a design problem of the twin engine concept for Silent Supersonic Business Jet (SSBJ). This problem aims to find main wing, body, tail wing and engine nacelle configurations, which can minimize both sonic boom and drag in a supersonic cruising flight. The multi-objective genetic algorithm (MOGA) coupled with the Kriging model has been used to globally and effectively search for optimal design candidates in the multi-objective problem. The drag and the sonic boom have been evaluated by the computational fluid dynamics (CFD) simulation and the waveform parameter method. As a result, the present optimization has successfully obtained low-boom and low-drag design candidates, which are better than the baseline design by more than 40% regarding each performance. Moreover, the structure of design space has been visualized by the self-organizing map (SOM).

    1. The Impact of Silent and Freeze-Frame Viewing Techniques of Video Materials on the Intermediate EFL Learners’ Listening Comprehension

      Directory of Open Access Journals (Sweden)

      Sara Shahani

      2015-05-01

      Full Text Available The use of modern technologies has been widely prevalent among language learners, and video, in particular, as a valuable learning tool provides learners with comprehensible input. The present study investigated the effect of silent and freeze-frame viewing techniques of video materials on the intermediate English as a foreign language (EFL learners’ listening comprehension. To this end, 45 intermediate EFL learners participated in this quasi-experimental study. The results of one-way ANOVA revealed that there was a statistically significant difference between the experimental groups (using two types of viewing techniques and the control group. While the difference between the two experimental groups was not statistically significant, the experimental groups outperformed the control group significantly.

    2. Phase-locking and chaos in a silent Hodgkin-Huxley neuron exposed to sinusoidal electric field

      International Nuclear Information System (INIS)

      Che Yanqiu; Wang Jiang; Si Wenjie; Fei Xiangyang

      2009-01-01

      Neuronal firing patterns are related to the information processing in neural system. This paper investigates the response characteristics of a silent Hodgkin-Huxley neuron to the stimulation of externally-applied sinusoidal electric field. The neuron exhibits both p:q phase-locked (i.e. a periodic oscillation defined as p action potentials generated by q cycle stimulations) and chaotic behaviors, depending on the values of stimulus frequencies and amplitudes. In one-parameter space, a rich bifurcation structure including period-adding without chaos and phase-locking alternated with chaos suggests frequency discrimination of the neuronal firing patterns. Furthermore, by mapping out Arnold tongues, we partition the amplitude-frequency parameter space in terms of the qualitative behaviors of the neuron. Thus the neuron's information (firing patterns) encodes the stimulus information (amplitude and frequency), and vice versa

    3. Before and after Silent Spring: from chemical pesticides to biological control and integrated pest management--Britain, 1945-1980.

      Science.gov (United States)

      Gay, Hannah

      2012-07-01

      The use of chemical pesticides increased considerably after World War II, and ecological damage was noticeable by the late 1940s. This paper outlines some ecological problems experienced during the post-war period in the UK, and in parts of what is now Malaysia. Also discussed is the government's response. Although Rachel Carson's book, Silent Spring (1962), was important in bringing the problems to a wider public, she was not alone in sounding the alarm. Pressure from the public and from British scientists led, among other things, to the founding of the Natural Environment Research Council in 1965. By the 1970s, environmentalism was an important movement, and funding for ecological and environmental research was forthcoming even during the economic recession. Some of the recipients were ecologists working at Imperial College London. Moved by the political climate, and by the evidence of ecological damage, they carried out research on the biological control of insect pests.

    4. A control strategy for grid-side converter of DFIG under unbalanced condition based on Dig SILENT/Power Factory

      Science.gov (United States)

      Han, Pingping; Zhang, Haitian; Chen, Lingqi; Zhang, Xiaoan

      2018-01-01

      The models of doubly fed induction generator (DFIG) and its grid-side converter (GSC) are established under unbalanced grid condition based on DIgSILENT/PowerFactory. According to the mathematical model, the vector equations of positive and negative sequence voltage and current are deduced in the positive sequence synchronous rotating reference frame d-q-0 when the characteristics of the simulation software are considered adequately. Moreover, the reference value of current component of GSC in the positive sequence frame d-q-0 under unbalanced condition can be obtained to improve the traditional control of GSC when the national issue of unbalanced current limits is combined. The simulated results indicate that the control strategy can restrain negative sequence current and the two times frequency power wave of GSC’s ac side effectively. The voltage of DC bus can be maintained a constant to ensure the uninterrupted operation of DFIG under unbalanced grid condition eventually.

    5. Effects of DBS, premotor rTMS, and levodopa on motor function and silent period in advanced Parkinson's disease

      DEFF Research Database (Denmark)

      Bäumer, Tobias; Hidding, Ute; Hamel, Wolfgang

      2009-01-01

      Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a widely used and highly effective treatment for patients with advanced Parkinson's disease (PD). Repetitive TMS (rTMS) applied to motor cortical areas has also been shown to improve symptoms in PD and modulate motor cortical...... excitability. Here, we compared clinical and neurophysiological effects of STN stimulation with those of 1 Hz rTMS given to the dorsal premotor cortex (PMd) and those following intake of levodopa in a group of PD patients with advanced disease. Ten PD patients were studied on 2 consecutive days before...... and after surgery. Clinical effects were determined using the UPDRS motor score. Motor thresholds, motor-evoked potential (MEP) amplitudes during slight voluntary contraction, and the cortical silent periods (SP) were measured using TMS. Before surgery effects of levodopa and 1 Hz PMd rTMS and after surgery...

    6. Defect induced activation of Raman silent modes in rf co-sputtered Mn doped ZnO thin films

      Energy Technology Data Exchange (ETDEWEB)

      Yadav, Harish Kumar [Department of Physics and Astrophysics, University of Delhi, Delhi-110007 (India); Sreenivas, K [Department of Physics and Astrophysics, University of Delhi, Delhi-110007 (India); Katiyar, R S [Department of Physics, University of Puerto Rico, San Juan, PR 00931-3343 (Puerto Rico); Gupta, Vinay [Department of Physics and Astrophysics, University of Delhi, Delhi-110007 (India)

      2007-10-07

      We study the influence of Mn doping on the vibrational properties of rf sputtered ZnO thin films. Raman spectra of the Mn doped ZnO samples reveal two additional vibrational modes, in addition to the host phonon modes, at 252 and 524 cm{sup -1}. The intensity of the additional modes increases continuously with Mn concentration in ZnO and can be used as an indication of Mn incorporation in ZnO. The modes are assigned to the activation of ZnO silent modes due to relaxation of Raman selection rules produced by the breakdown of the translational symmetry of the crystal lattice with the incorporation of Mn at the Zn site. Furthermore, the A{sub 1} (LO) mode is observed with very high intensity in the Raman spectra of undoped ZnO thin film and is attributed to the built-in electric field at the grain boundaries.

    7. Defect induced activation of Raman silent modes in rf co-sputtered Mn doped ZnO thin films

      International Nuclear Information System (INIS)

      Yadav, Harish Kumar; Sreenivas, K; Katiyar, R S; Gupta, Vinay

      2007-01-01

      We study the influence of Mn doping on the vibrational properties of rf sputtered ZnO thin films. Raman spectra of the Mn doped ZnO samples reveal two additional vibrational modes, in addition to the host phonon modes, at 252 and 524 cm -1 . The intensity of the additional modes increases continuously with Mn concentration in ZnO and can be used as an indication of Mn incorporation in ZnO. The modes are assigned to the activation of ZnO silent modes due to relaxation of Raman selection rules produced by the breakdown of the translational symmetry of the crystal lattice with the incorporation of Mn at the Zn site. Furthermore, the A 1 (LO) mode is observed with very high intensity in the Raman spectra of undoped ZnO thin film and is attributed to the built-in electric field at the grain boundaries

    8. Epistaxis as the First Manifestation of Silent Renal Cell Carcinoma: A Case Report with Relevant Literature Review

      International Nuclear Information System (INIS)

      Lee, Seung Min; Kim, You Me; Kim, Bong Man

      2016-01-01

      The paranasal sinuses are known to be a rare location for metastasis. Renal cell carcinoma (RCC) is the most frequent primary tumor to metastasize to the sinonasal region, followed by lung and breast cancer. In particular, clear cell type RCC, which represents approximately 85% of RCCs, is characterized by early metastasis, and it sometimes spreads to unusual sites (1, 2). Metastatic tumors in the paranasal sinuses are distributed in the maxillary, sphenoid, ethmoid, and frontal sinuses, in order of decreasing frequency. Symptoms are usually nonspecific, but epistaxis is the most common sign, due to the hypervascularity of the primary tumor. The prognosis is uncertain, but the 5-year survival rate fluctuates between 15% and 30%. The purpose of this case report is to document a rare case of silent RCC that first presented as epistaxis due to nasal cavity and ethmoid sinus metastasis

    9. Occurrence of silent cerebral infarction in pre-senile, senile subjects with depressive states; MRI findings and its distribution

      Energy Technology Data Exchange (ETDEWEB)

      Fujikawa, Tokumi; Yamawaki, Shigeto (Hiroshima Univ. (Japan). School of Medicine); Touhouda, Yoshikuni

      1993-02-01

      We examined the relationship between pre-senile, senile depressive states and silent cerebral infarction (SCI) using magnetic resonance imaging (MRI). The diagnostic criteria of major depression according to DSM-3-R was used to diagnose. Patients in whom stroke had occurred or who had local neurologic symptoms were not included. About half of the patients with depressive states of pre-senile onset and most of the patients with those of senile onset had SCI, were considered to be organic-depressive states complicated with SCI. Because patients with depressive states with SCI are at high risk of occurrence of stroke, we designated this condition 'pre-stroke depression', and classified it with endogenous depression. At this time, it is important to begin therapy for cerebrovascular disease. (author).

    10. Binocular neurons in parastriate cortex: interocular 'matching' of receptive field properties, eye dominance and strength of silent suppression.

      Directory of Open Access Journals (Sweden)

      Phillip A Romo

      Full Text Available Spike-responses of single binocular neurons were recorded from a distinct part of primary visual cortex, the parastriate cortex (cytoarchitectonic area 18 of anaesthetized and immobilized domestic cats. Functional identification of neurons was based on the ratios of phase-variant (F1 component to the mean firing rate (F0 of their spike-responses to optimized (orientation, direction, spatial and temporal frequencies and size sine-wave-luminance-modulated drifting grating patches presented separately via each eye. In over 95% of neurons, the interocular differences in the phase-sensitivities (differences in F1/F0 spike-response ratios were small (≤ 0.3 and in over 80% of neurons, the interocular differences in preferred orientations were ≤ 10°. The interocular correlations of the direction selectivity indices and optimal spatial frequencies, like those of the phase sensitivies and optimal orientations, were also strong (coefficients of correlation r ≥ 0.7005. By contrast, the interocular correlations of the optimal temporal frequencies, the diameters of summation areas of the excitatory responses and suppression indices were weak (coefficients of correlation r ≤ 0.4585. In cells with high eye dominance indices (HEDI cells, the mean magnitudes of suppressions evoked by stimulation of silent, extra-classical receptive fields via the non-dominant eyes, were significantly greater than those when the stimuli were presented via the dominant eyes. We argue that the well documented 'eye-origin specific' segregation of the lateral geniculate inputs underpinning distinct eye dominance columns in primary visual cortices of mammals with frontally positioned eyes (distinct eye dominance columns, combined with significant interocular differences in the strength of silent suppressive fields, putatively contribute to binocular stereoscopic vision.

    11. Low fetal hemoglobin percentage is associated with silent brain lesions in adults with homozygous sickle cell disease.

      Science.gov (United States)

      Calvet, David; Tuilier, Titien; Mélé, Nicolas; Turc, Guillaume; Habibi, Anoosha; Abdallah, Nassim Ait; Majhadi, Loubna; Hemery, François; Edjlali, Myriam; Galacteros, Frédéric; Bartolucci, Pablo

      2017-12-12

      Silent white matter changes (WMCs) on brain imaging are common in individuals with sickle cell disease (SCD) and are associated with cognitive deficits in children. We investigated the factors predictive of WMCs in adults with homozygous SCD and no history of neurological conditions. Patients were recruited from a cohort of adults with homozygous SCD followed up at an adult sickle cell referral center for which steady-state measurements of biological parameters and magnetic resonance imaging scans of the brain were available. WMCs were rated by consensus, on a validated age-related WMC scale. The prevalence of WMCs was 49% (95% confidence interval [CI], 39%-60%) in the 83 patients without vasculopathy included. In univariable analysis, the patients who had WMCs were more likely to be older ( P = .003) and to have hypertension ( P = .02), a lower mean corpuscular volume ( P = .005), a lower corpuscular hemoglobin concentration ( P = .008), and a lower fetal hemoglobin percentage (%HbF) ( P = .003). In multivariable analysis, only a lower %HbF remained associated with the presence of WMCs (odds ratio [OR] per 1% increase in %HbF, 0.84; 95% CI, 0.72-0.97; P = .021). %HbF was also associated with WMC burden ( P for trend = .007). Multivariable ordinal logistic regression showed an inverse relationship between WMC burden (age-related WMC score divided into 4 strata) and HbF level (OR for 1% increase in %HbF, 0.89; 95% CI, 0.79-0.99; P = .039). Our study suggests that HbF may protect against silent WMCs, decreasing the likelihood of WMCs being present and their severity. It may therefore be beneficial to increase HbF levels in patients with WMCs.

    12. Pitting type of pretibial edema in a patient with silent thyroiditis successfully treated by angiotensin ii receptor blockade.

      Science.gov (United States)

      Kazama, Itsuro; Mori, Yoko; Baba, Asuka; Nakajima, Toshiyuki

      2014-01-01

      Female, 56 FINAL DIAGNOSIS: Thyroiditis - silent Symptoms: Palpitations • pretibial pitting edema • short of breath • sweating - Clinical Procedure: - Specialty: Endocrinology and Metabolic. Unknown etiology. Hyper- or hypothyroidism sometimes causes pretibial myxedema characterized by non-pitting infiltration of a proteinaceous ground substance. However, in those patients, the "pitting" type of pretibial edema as a result of increased sodium and fluid retention or vascular hyper-permeability rarely occurs, except in cases complicated by heart failures due to severe cardiomyopathy or pulmonary hypertension. A 56-year-old woman developed bilateral pretibial pitting edema, followed by occasional sweating, palpitations, and shortness of breath, which persisted for more than 2 months. The diagnosis of hyperthyroidism due to silent thyroiditis was supported by elevated levels of free thyroxine (T4) and triiodothyronine (T3), with a marked decrease in thyroid-stimulating hormone (TSH), and the negative results for TSH receptor antibodies with typical findings of destructive thyrotoxicosis. Despite her "pitting" type of pretibial edema, a chest radio-graph demonstrated the absence of cardiomyopathy or congestive heart failure. Oral administration of angiotensin II receptor blocker (ARB) was initiated for her systolic hypertension, with a relatively higher elevation of plasma renin activity compared to that of the aldosterone level. Although the symptoms characteristic to hyperthyroidism, such as increased sweating, palpitations and shortness of breath, slowly improved with a spontaneous resolution of the disease, ARB quickly resolved the pretibial pitting edema shortly after the administration.. In this case, increased activity of the renin-angiotensin-aldosterone system stimulated by thyroid hormone was likely responsible for the patient's pitting type of edema. The pharmacological blockade of the renin-angiotensin-aldosterone system was thought to be effective for

    13. Food irradiation - pros and cons

      International Nuclear Information System (INIS)

      1983-01-01

      The use of ionising radiation for food preservation is a much-disputed topic, both among experts and among consumers. Pros and cons of this issue were discussed in detail at the consumers' forum. Professor Dr. Johannes Friedrich Diehl, Director of the Institute for Biochemistry of the Food Research Centre, Karlsruhe, is a well-known supporter of the new method of food preservation; he sees advantages in the radiopreservation of food because, for example, losses due to inedibility are reduced, the danger of salmonellosis is decreased, just as the use of chemicals. He thinks this method to be without danger to health, shown by many years of experience. Opponents to food irradiation like Prof. Dr. Konrad Pfeilsticker, Professor for food science and food chemistry at the Bonn University deem the method to be unnecessary and raise the problem of qualitative changes caused in the food. In the course of the discussions, the pros and cons seemed to balance each other out. (orig./AJ) [de

    14. De paseo con los Bourbaki

      Directory of Open Access Journals (Sweden)

      Miquel Escudero

      2012-04-01

      Full Text Available Setenta y siete años después de la fundación del grupo Bourbaki, procedemos a una reflexión que puede ser útil para los estudiantes que acaso no sepan de su existencia, ni tan siquiera los de matemáticas. Sería interesante conocer que a este grupo se le debe el signo del vacío como conjunto. Con todo lo discutible que sea el método Bourbaki en su reinterpretación de la matemática, no cabe duda de su importante repercusión hasta el punto de que ha marcado una época. Hay un antes y un después tras su irrupción, ningún matemático de primera fila de la segunda mitad del siglo XX fue ajeno a su influjo, para encabezarlo o para reprobarlo. Comenzaron como una juvenil extravagancia, pero repleta de conocimientos y con decidida voluntad de aprehender el rigor de forma exhaustiva.

    15. Tratamiento del paciente con artrosis

      Directory of Open Access Journals (Sweden)

      Francisco Vargas Negrín

      2014-01-01

      Full Text Available El manejo terapéutico del paciente con artrosis tiene como objetivo disminuir la sintomatología dolorosa e inflamatoria, mejorar la capacidad funcional del paciente y la aplicación de intervenciones terapéuticas eficaces y lo más seguras posibles. Un enfoque centrado en el paciente implica su participación activa en el diseño del plan terapéutico y en la toma de decisiones informadas oportunas en todas las etapas de la enfermedad. La educación terapéutica, la actividad física y el ejercicio terapéutico junto con el control de peso, en caso de sobrepeso u obesidad, constituyen el núcleo central del tratamiento. Los autocuidados individuales y por los familiares son fundamentales en el control del día a día del paciente. El uso de terapias físicas, ayudas técnicas (bastón, etc. y de fármacos tipo analgésicos simples, opioides y antiinflamatorios tiene evidencias demostradas en el control del dolor, mejora la funcionalidad y la calidad de vida del paciente y una clara recomendación de uso en el tratamiento de la artrosis. La cirugía conservadora y la de reemplazo articular se indican en los casos en los que no se logran los objetivos terapéuticos en casos concretos.

    16. Plagiarism: A silent epidemic in scientific writing - Reasons, recognition and remedies.

      Science.gov (United States)

      Debnath, Jyotindu

      2016-04-01

      Plagiarism is one of the most serious forms of scientific misconduct prevalent today and is an important reason for significant proportion of rejection of manuscripts and retraction of published articles. It is time for the medical fraternity to unanimously adopt a 'zero tolerance' policy towards this menace. While responsibility for ensuring a plagiarism-free manuscript primarily lies with the authors, editors cannot absolve themselves of their accountability. The only way to write a plagiarism-free manuscript for an author is to write an article in his/her own words, literally and figuratively. This article discusses various types of plagiarism, reasons for increasingly reported instances of plagiarism, pros and cons of use of plagiarism detection tools for detecting plagiarism and role of authors and editors in preventing/avoiding plagiarism in a submitted manuscript. Regular usage of professional plagiarism detection tools for similarity checks with critical interpretation by the editorial team at the pre-review stage will certainly help in reducing the menace of plagiarism in submitted manuscripts.

    17. Cons ICARUS, TIGER and Fascism

      Directory of Open Access Journals (Sweden)

      Janez Vrečko

      2010-12-01

      Full Text Available Like the scientists of their time, Russian artists in the 1920s considered gravity the central problem – a view which points to the close harmony between modern physics and the avant-garde. It was only with the constructivist movement that the Icarus revolution grasped the principles of the “mobile philosophy” (3.651 which was almost at the same time recognised by modern physics as well. The static view of the world became obsolete, space and time were no longer absolute values. It was necessary to transcend Euclidean geometry, shake off the political ʻshackles on one’s hands’ and surrender to Lisicki’s imaginary space, where “At 2000 metres in the air / there is no more perspective” (Integrals 276.  Kosovel’s Icarus project accorded with Tatlin’s, and both of them accorded with the quintessential aims of the constructivist movement. It is no accident that Kosovel wished to name one of his poetry collections The Dream of Icarus. Poems on the Icarus theme, such as “Cons Icarus”, “Evacuation of the Spirit”, “Eh, Hey”, “A Heart in Alcohol” etc. belong to the group of Kosovel’s conses which follow his “mobile philosophy” (3.650 and “letters growing into space” (Int. 282.  The question “Man, do you want up in the air?” (Int. 128 will remain a question until the moment when man is finally ready to transcend the existing boundary and dive “beyond”. Hence Kosovel’s clear-cut contrast between the “green windows of an illuminated / express on a viaduct”, which moves horizontally and is, like a water current, subject to the earth’s gravity, and “the spirit in space”, whose direction of motion is “the perpendicular of the spirit”, atectonicity. “The spirit burns in space”: fire is an element that knows vertical movement alone, the only one of the elements to outgrow and transcend the earth’s gravity, therefore it is associated with another mythological figure important for

    18. Fare astronomia con piccoli telescopi

      CERN Document Server

      Gainer, Michael K

      2007-01-01

      Non sono necessariamente richiesti strumenti mastodontici per produrre risultati scientificamente validi nel campo dell’astronomia. Anche l’astrofilo dotato di un piccolo telescopio, con un diametro di soli 8-9 cm, può contribuire alla scienza del cielo realizzando utili osservazioni del Sole, della Luna, dei pianeti, delle comete, degli asteroidi, delle stelle doppie o variabili, delle nebulose e degli ammassi stellari. Il manuale di M.K. Gainer spiega quale sia la dotazione minima (un piccolo telescopio, un computer, una semplice fotocamera digitale), come utilizzarla, e quali siano le tecniche appropriate da adottare nelle osservazioni. Offre inoltre schemi per interpretare e ridurre i dati raccolti, nonché schede da compilare e da spedire ai centri di raccolta internazionali. Questo libro è il passaporto grazie al quale l’astrofilo può entrare a pieno titolo nel mondo affascinante della scienza astronomica.

    19. Depresion en pacientes con alteraciones del tiroides

      OpenAIRE

      Radanovic-Grguric´, Ljiljana; Filakovic´, Pavo; Barkic´, Jelena; Mandic´, Nikola; Karner, Ivan; Smoje, Juraj

      2003-01-01

      Nuestro estudio fue realizado en un grupo de 53 mujeres con disfunción tiroidea y 28 mujeres con depresión mayor. Empleamos la Escala de la Depresión de Hamilton, la Escala de Autoevaluación de la Depresión de Zung y la Escala sobre la Impresión Clínica Global. Los resultados del estudio demuestran que la mayoría de los pacientes con disfunción tiroidea se mostraron clínicamente significativos en cuanto al trastorno depresivo. Los episodios depresivos son más frecuentes en pacientes con hipot...

    20. Aprende Ajedrez con Rey - Parte 2

      OpenAIRE

      ESTÉVEZ MONTERO, RAÚL; Lloret Mauri, Jaime

      2016-01-01

      Es una pieza audiovisual creada con el objeto de atraer la atención de los niños de muy corta edad con el ajedrez y familiarizarlos con todas sus piezas y movimientos. Es una animación dirigida a un público infantil presentada por dibujos animados en 2D, en la que se ha intentado respetar en todo momento el argot de la comunidad ajedredística. En este video se presenta la segunda parte. Estévez Montero, R.; Lloret Mauri, J. (2016). Aprende Ajedrez con Rey - Parte 2. http://hdl.handle.net/1...

    1. Aprende Ajedrez con Rey - Parte 1

      OpenAIRE

      ESTÉVEZ MONTERO, RAÚL; Lloret Mauri, Jaime

      2016-01-01

      Es una pieza audiovisual creada con el objeto de atraer la atención de los niños de muy corta edad con el ajedrez y familiarizarlos con todas sus piezas y movimientos. Es una animación dirigida a un público infantil presentada por dibujos animados en 2D, en la que se ha intentado respetar en todo momento el argot de la comunidad ajedredística. En este video se presenta la primera parte. Estévez Montero, R.; Lloret Mauri, J. (2016). Aprende Ajedrez con Rey - Parte 1. http://hdl.handle.net/1...

    2. Angiografía del día siguiente tras fibrinólisis exitosa frente al tratamiento convencional, en el síndrome coronario agudo con elevación del segmento ST, fibrinolisado Angiography performed the next day after successful thrombolysis versus conventional treatment in acute coronary syndrome with ST segment elevation

      Directory of Open Access Journals (Sweden)

      José D Cascón-Pérez

      2012-01-01

      Full Text Available Introducción y objetivos: la incorporación de las nuevas guías de actuación de la Sociedad Europea de Cardiología en el síndrome coronario agudo, con coronariografía precoz (24 horas tras trombólisis, incluso si es efectiva y sin necesidad de demostrar signos de isquemia residual, en los casos en los que no se realiza angioplastia primaria, ha supuesto un reto respecto a la forma tradicional de actuar en los Servicios de Cardiología. Métodos: durante 2007, 2008 y la primera mitad de 2009 se atendieron 266 pacientes con infarto agudo del miocardio con ST elevado tratados con trombólisis. De ellos, y tras excluir los rescates (41, en 94 (42% se realizó cateterismo dentro de las primeras 24 horas (angiografía del día siguiente y en los 131 (58% restantes se siguió una estrategia convencional con test de provocación de isquemia (tratamiento convencional. Resultados: en el primer grupo, la estancia media fue de 7,3 ± 3 días [mediana, rango intercuantílico: 7 (5-8]. La incidencia de eventos mortales al año fue de 3 (4%. No hubo ningún sangrado mayor; sólo 20 de ellos (22% presentaron hematomas inguinales mayores de 2 cm. En el segundo, la estancia media fue de 10,2 ± 6,3 días [9 (6-13], significativamente mayor (pIntroduction and objectives: The introduction of new practice guidelines of the European Society of Cardiology in acute coronary syndrome with early coronary angiography (24 hours after thrombolysis, even if it is effective without showing signs of residual ischemia in the cases where primary angioplasty is not performed, has been a challenge over the traditional approach in the Departments of Cardiology. Methods: During 2007, 2008 and the first half of 2009, 266 patients with acute myocardial infarction with ST segment elevation were treated with thrombolysis. After excluding the bailouts (41, in 94 (42% of them, a catheterization was peformed within the first 24 hours (next day angiography and the remaining 131 (58

    3. Efecto del hialuronato de zinc sobre las úlceras en pacientes con diabetes Zinc hyaluronate effects on ulcers in diabetic patients

      Directory of Open Access Journals (Sweden)

      Fernando Ramos Cuevas

      2007-06-01

      Full Text Available Contexto: La úlcera en el pie diabético es una de las principales complicaciones de la diabetes en extremidades bajas. Del 50 al 70% de las amputaciones en extremidades bajas se realizan a pacientes con diabetes. El hialuronato de zinc ha sido probado en el tratamiento de las úlceras diabéticas del pie con resultados prometedores. Objetivo general: Determinar el grado de eficacia del hialuronato de zinc en la curación de úlceras del pie diabético. Diseño: Ensayo terapéutico abierto al azar. Se les dio seguimiento a los pacientes durante un período de doce semanas de junio a diciembre de 2004. Ubicación: Centro de cuidado terciario. Clínica del Pie Diabético. Pacientes: Fueron seleccionados por muestreo consecutivo cincuenta pacientes con diabetes tipo 2 con úlcera en pie, de ambos sexos y con edades entre los 40 y los 80 años y sin una isquemia más baja de la extremidad. Veinticinco de ellos fueron asignados aleatoriamente al grupo del hialuronato de zinc y el resto al grupo de control (tratamiento convencional. La distribución por sexo de género fue similar en ambos grupos, once del femenino (44% y 14 del masculino (56%. La edad promedio en el grupo de la combinación del ácido hialurónico y zinc fue 56,76 ± 8,78 y en el convencional 60,12 ± 8,42, NS. ningún paciente del grupo de hialuronato de zinc abandonó o fue retirado durante el período del estudio. Un paciente del grupo de control falleció. Intervención: El hialuronato de zinc fue aplicado una vez al día en la superficie de la úlcera después de limpiarla con la solución fisiológica salina. Medida principal del resultado: La eficacia del hialuronato de zinc fue determinada por las semanas que se requirieron para conseguir el cierre completo de la úlcera con el tejido fino epitelial (tiempo curativo medio. Material y métodos: Ensayo clínico controlado. Pacientes con úlceras propias del pie diabético. 1 de julio al 30 de septiembre de 2004, 25 pacientes

    4. PÚRPURA TROMBOCITOPÉNICA TROMBÓTICA: DIAGNÓSTICO DIFERENCIAL CON EL SÍNDROME HEMOLÍTICO URÉMICO. PRESENTACIÓN DE UN CASO

      Directory of Open Access Journals (Sweden)

      Parra Velasco Pedro

      2016-07-01

      Full Text Available La púrpura trombocitopénica trombótica (PTT pertenece a las microangiopatías trombóticas (MAT; un grupo de enfermedades caracterizadas por la presencia de anemia hemolítica microangiopática, trombocitopenia y trombosis microvascular. Ésta última característica, es causante de isquemia que puede manifestarse a diferentes niveles tales como el riñón y sistema nervioso central. Las MAT incluyen varias patologías dentro de las cuales se destacan además de la PTT, el síndrome hemolítico urémico (SHU y el síndrome hemolítico urémico atípico (SHUa, cuyas alteraciones fisiopatológicas difieren de acuerdo a la enfermedad. La pentada clásica de la PTT describe trombocitopenia, anemia hemolítica microangiopática, fiebre, síntomas neurológicos y falla renal. A pesar de que en la PTT la afectación neurológica es más frecuente que la disfunción renal, los síntomas pueden solaparse entre las 3 enfermedades, dificultando un diagnóstico preciso. Es por ello que en la actualidad se observa más casos de PTT con manifestaciones atípicas, como lo son la disfunción renal como manifestación principal, en ausencia de sintomatología neurológica. Esto ha llevado a que las pruebas moleculares se vuelvan imprescindibles para un diagnóstico preciso. A continuación, se describe el caso de un paciente con PTT y déficit severo de ADAMTS 13, quien debutó con disfunción renal, sin afectación neurológica, respondiendo al tratamiento con plasmaferesis. Palabras Clave: Púrpura trombocitopénica trombótica, síndrome hemolítico urémico, anemia hemolítica.

    5. NINJ2 SNP may affect the onset age of first-ever ischemic stroke without increasing silent cerebrovascular lesions

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      Kim Dong-Eog

      2012-03-01

      Full Text Available Abstract Background To investigate if single nucleotide polymorphisms on chromosome 12p13 and within 11 kb of the gene NINJ2 would be associated with earlier-onset (vs. late-onset first-ever ischemic stroke and increase silent cerebrovascular lesions prior to the manifestation of the stroke. Methods We prospectively enrolled 164 patients (67.6 ± 12.9 years, 92 men admitted with first-ever ischemic strokes. All patients underwent genotyping of rs11833579 and rs12425791 as well as systemic investigations including magnetic resonance (MR imaging and other vascular workup. Stroke-related MR lesions were registered on a brain-template-set using a custom-built software package 'Image_QNA': high-signal-intensity ischemic lesions on diffusion, T2-weighted, or fluid attenuation inversion recovery (FLAIR MR images, and low signal intensity hemorrhagic lesions on gradient-echo MR images. Results The rs11833579 A/A or G/A genotype was independently associated with the first-ever ischemic stroke before the age 59 vs. 59 or over, after adjusting for cardiovascular risk factors and prior medication of antiplatelet or anticoagulant drugs, increasing the risk by about 2.5 fold. In the quantitative MR lesion maps from age-sex matched subgroups (n = 124 or 126, there was no difference between the patients with the rs11833579 A/A or G/A genotype and those with the G/G genotype. Unexpectedly, the extent of leukoaraiosis on FLAIR-MR images tended to be smaller in the corona radiata and centrum semiovale of the patients with the rs12425791 A/A or G/A genotype than in those with the G/G genotype (P = 0.052. Neither the rs11833579 nor the rs12425791 genotype significantly affected initial stroke severity; however the latter was associated with relatively low modified Rankin scale scores at 1 year after stroke. Conclusions The rs11833579 A/A or G/A genotype may bring forward the onset age of first-ever ischemic stroke without increasing silent cerebrovascular lesions

    6. Plantas cubanas con efecto antiinflamatorio

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      Ada Ivis Regalado Veloz

      Full Text Available La actividad antiinflamatoria suscita gran interés científico en el área farmacológica, debido a que muchas enfermedades en su evolución cursan por procesos inflamatorios (artritis reumatoide, ateroesclerosis, cáncer, diabetes, gota, asma, dermatitis, trastornos neurodegenerativos y diversas dolencias menores. Las enfermedades inflamatorias constituyen un problema de salud importante, debido a la falta de medicamentos eficaces y seguros para su uso por periodos prolongados. Hoy en día se trabaja en la búsqueda de alternativas de antiinflamatorios más seguros, en el que las plantas medicinales, una de las formas más antiguas de tratamiento, constituyen una elección a considerar. En este trabajo se realizó una revisión bibliográfica, sobre especies de plantas que crecen en Cuba que le reportan propiedades farmacológicas como antinflamatorios. En la revisión de la literatura se utilizó la base de datos Medline (vía PubMed, así como revistas nacionales desde el periodo de 2000 hasta el presente, con las palabras claves "inflamación" y "plantas cubanas antiinflamatorias" o "actividad antiinflamatoria" y "plantas medicinales".

    7. Hospitalidad, con y sin papeles

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      Ana Paula Penchaszadeh

      Full Text Available Resumen El objetivo de este artículo es vincular el trabajo sobre el archivo de Jacques Derrida con la experiencia de la hospitalidad. Se intentará mostrar que, por un lado, se trata siempre de los papeles, de la legitimidad que éstos otorgan o no tanto a nivel filosófico (deseo de poseer los papeles que autoricen tal o cual decisión interpretativa, como a nivel político ("tener papeles" como el principio básico de todo derecho a tener derechos, de todo derecho a la comunidad. Mas también, por otro lado, se intentará pensar aquello que arruina la idea misma de tener o no tener (papeles, la idea de propiedad, aquello que hace imposible fundar una decisión o identidad en última instancia y, por ende, una soberanía, una frontera. La hospitalidad, la llegada inminente del otro, representa un desafío político y ético para la filosofía: pues no se trata de un saber, sino de una experiencia transformando el sustrato del nos-otros, del ser común.

    8. Itinerari Musicali con la Wiild

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      Elisabetta Nanni

      2013-03-01

      Full Text Available La Wiild, acronimo di Wiimote Lavagna Digitale, è uno strumento didattico che utilizza il telecomando della Wii, il famoso gioco della Nintendo, insieme a un software libero, rendendolo così estremamente versatile. Non vincolato a software proprietario, il suo utilizzo è legato alla capacità dell’insegnante di ripartire dalla didattica, dalle risorse selezionate e dall’epistemologia di ogni singola disciplina, trovando così nel proprio contesto un ruolo per le tecnologie. Il contributo presenta ipotesi di lavoro per l’educazione musicale nella scuola secondaria di primo grado che si sviluppano sia attraverso lo studio del rapporto suono/segno con affinità pittoriche e successiva codificazione grafica, sia attraverso un’attività di laboratorio in cui co-costruire percorsi storico-musicali. La Wiild diventerà davvero utile ed efficace nel momento in cui, affiancando le risorse selezionate dal docente, verrà utilizzata senza essere notata, giocando un ruolo di strumento tecnologico «normale e trasparente».

    9. The role of ion irradiation in activating silent Raman modes via tuning in plasmonic behaviour and surface disorder of Au/ZnO/Pt NFG system

      Science.gov (United States)

      Singh, Udai B.; Gautam, Subodh K.; Kumar, Sunil; Ojha, Sunil; Ghosh, Santanu; Singh, Fouran

      2017-09-01

      The perceptible progression of Raman modes of zinc oxide (ZnO) is studied in nanostructures film gap (Au (10 nm)/ZnO (70 nm)/Pt (50 nm)) system with 1.2 MeV Xe ion irradiation. Unattainable silent Raman modes of ZnO turn out to be strongly visible after ion irradiation. The creation of ion-beam-induced lattice disorder, defects, and impurities in a ZnO layer leads to breakdown the translational crystal symmetry that results in the origin of silent modes. The formation of hot-spots in the ZnO layer of the NFG system also supports the enhancement of the intensity of Raman modes. Overall results are attributed to combined effects of lattice disorder, defects, and impurities along with plasmonic effect and explained in the framework of elastic-thermal-spike formation.

    10. A silent allele in the locus D5S818 contained within the PowerPlex®21 PCR Amplification Kit.

      Science.gov (United States)

      Chen, Ling; Tai, Yunchun; Qiu, Pingming; Du, Weian; Liu, Chao

      2015-11-01

      Three paternity tests cases were found with a single locus mismatch at the locus D5S818 with PowerPlex®21 PCR Amplification Kit (Promega). Forward and reverse primers were redesigned to type the samples again and to evaluate if there were alleles dropped out. The results showed the existence of a silent allele 12 in all the three families, due to a point mutation that changed cytosine to adenine at 90 nucleotides upstream from the 5' end of the AGAT repeat sequences in all the six individuals. A single locus mismatch due to a silent allele may occur in any locus using any kit. Therefore, we recommend using multiple kits to confirm the results in paternity testing cases with mismatches, especially when there is a single locus mismatch with homozygote involved. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

    11. Bases tratadas con cemento, en California

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      Chinchilla, M.

      1962-05-01

      Full Text Available El uso de bases tratadas con cemento para autopistas se inició en el Estado de California en 1938, empleándose para carreteras con determinadas condiciones de tráfico. Inicialmente, se especificó el uso obligatorio de plantas mezcladoras para asegurar el debido control de las proporciones adecuadas.

    12. Activation of the Silent Secondary Metabolite Production by Introducing Neomycin-Resistance in a Marine-Derived Penicillium purpurogenum G59

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      Chang-Jing Wu

      2015-04-01

      Full Text Available Introduction of neomycin-resistance into a marine-derived, wild-type Penicillium purpurogenum G59 resulted in activation of silent biosynthetic pathways for the secondary metabolite production. Upon treatment of G59 spores with neomycin and dimethyl sulfoxide (DMSO, a total of 56 mutants were obtained by single colony isolation. The acquired resistance of mutants to neomycin was testified by the resistance test. In contrast to the G59 strain, the EtOAc extracts of 28 mutants inhibited the human cancer K562 cells, indicating that the 28 mutants have acquired the capability to produce bioactive metabolites. HPLC-photodiode array detector (PDAD-UV and HPLC-electron spray ionization (ESI-MS analyses further indicated that diverse secondary metabolites have been newly produced in the bioactive mutant extracts. Followed isolation and characterization demonstrated that five bioactive secondary metabolites, curvularin (1, citrinin (2, penicitrinone A (3, erythro-23-O-methylneocyclocitrinol (4 and 22E-7α-methoxy-5α, 6α-epoxyergosta-8(14,22-dien-3β-ol (5, were newly produced by a mutant, 4-30, compared to the G59 strain. All 1–5 were also not yet found in the secondary metabolites of other wild type P. purpurogenum strains. Compounds 1–5 inhibited human cancer K562, HL-60, HeLa and BGC-823 cells to varying extents. Both present bioassays and chemical investigations demonstrated that the introduction of neomycin-resistance into the marine-derived fungal G59 strain could activate silent secondary metabolite production. The present work not only extended the previous DMSO-mediated method for introducing drug-resistance in fungi both in DMSO concentrations and antibiotics, but also additionally exemplified effectiveness of this method for activating silent fungal secondary metabolites. This method could be applied to other fungal isolates to elicit their metabolic potentials to investigate secondary metabolites from silent biosynthetic pathways.

    13. “The One Who Chases You Away Does Not Tell You Go”: Silent Refusals and Complex Power Relations in Research Consent Processes in Coastal Kenya

      Science.gov (United States)

      Kamuya, Dorcas M.; Theobald, Sally J.; Marsh, Vicki; Parker, Michael; Geissler, Wenzel P.; Molyneux, Sassy C.

      2015-01-01

      Consent processes have attracted significant research attention over the last decade, including in the global south. Although relevant studies suggest consent is a complex negotiated process involving multiple actors, most guidelines assume consent is a one-off encounter with a clear ‘yes’ or ‘no’ decision. In this paper we explore the concept of ‘silent refusals’, a situation where it is not clear whether potential participants want to join studies or those in studies want to withdraw from research, as they were not actively saying no. We draw on participant observation, in-depth interviews and group discussions conducted with a range of stakeholders in two large community based studies conducted by the KEMRI Wellcome Trust programme in coastal Kenya. We identified three broad inter-related rationales for silent refusals: 1) a strategy to avoid conflicts and safeguard relations within households, - for young women in particular—to appear to conform to the wishes of elders; 2) an approach to maintain friendly, appreciative and reciprocal relationships with fieldworkers, and the broader research programme; and 3) an effort to retain study benefits, either for individuals, whole households or wider communities. That refusals and underlying rationales were silent posed multiple dilemmas for fieldworkers, who are increasingly recognised to play a key interface role between researchers and communities in many settings. Silent refusals reflect and reinforce complex power relations embedded in decisions about research participation, with important implications for consent processes and broader research ethics practice. Fieldworkers need support to reflect upon and respond to the ethically charged environment they work in. PMID:25978465

    14. Co-simulation with DIgSILENT PowerFactory and Matlab: Optimal integration of plug-in electric vehicles in distribution networks

      DEFF Research Database (Denmark)

      García-Villalobos, J.; Zamora, I.; Marinelli, Mattia

      2017-01-01

      Smart grid concept is gaining more and more importance in electric power systems. In near term, electric grids will be more intelligent, interconnected and decentralised. Dealing with a significant number of distributed resources in a smart way, frequently requires the use of optimal control tech...... mean square (RMS) simulations on DIgSILENT PowerFactory. As an example, the implementation of a smart charging control for plug-in electric vehicles in electric distribution networks is explained....

    15. Prognostic importance of silent myocardial ischemia detected by intravenous dipyridamole thallium myocardial imaging in asymptomatic patients with coronary artery disease

      International Nuclear Information System (INIS)

      Younis, L.T.; Byers, S.; Shaw, L.; Barth, G.; Goodgold, H.; Chaitman, B.R.

      1989-01-01

      One hundred seven asymptomatic patients who underwent intravenous dipyridamole thallium imaging were evaluated to determine prognostic indicators of subsequent cardiac events over an average follow-up period of 14 +/- 10 months. Univariate analysis of 18 clinical, scintigraphic and angiographic variables revealed that a reversible thallium defect, a combined fixed and reversible thallium defect, number of segmental thallium defects and extent of coronary artery disease were significant predictors of subsequent cardiac events. Of the 13 patients who died or had a nonfatal infarction, 12 had a reversible thallium defect. Stepwise logistic regression analysis selected a reversible thallium defect as the only significant predictor of cardiac events. When death or myocardial infarction was the outcome variable, a combined fixed and reversible thallium defect was the only predictor of outcome. In patients without previous myocardial infarction, the cardiac event rate was significantly greater in those with an abnormal versus normal thallium scan (55% versus 12%, p less than 0.001). Thus, intravenous dipyridamole thallium scintigraphy is a useful noninvasive test to risk stratify asymptomatic patients with coronary artery disease. A reversible thallium defect most likely indicates silent myocardial ischemia in a sizable fraction of patients in this clinical subset and is associated with an unfavorable prognosis

    16. Boleros and Flamenco Dancing in the Early Silent Films. Narratives and Archetypes of Spanishness in the Early Twentieth Century

      Directory of Open Access Journals (Sweden)

      Cristina Cruces-Roldán

      2017-02-01

      Full Text Available The article locates and catalogues a corpus of 37 early cinema recordings (1894-1910 containing Spanish bolero and flamenco dances. These silent movies were recorded at universal exhibitions, or as a result of theatrical dramatizations, parodies and fiction stories, and are now in the archives of the Library of Congress, Gaumont-Pathé, Pathé and Frères Lumière collections and the Huntley Films Archive. An analysis of the contents of these archives demonstrate the potential of pioneering filmography as a documentary source for the construction and reproduction of national clichés. We consider two coexisting narratives in these early records: testimonial to dance as artistic expression and the identity discourse of «Spanishness» through the bodily disposition and environmental elements of the frames. The representation of the Hispanic archetype shows that early cinema was a continuist route of transmission of the aesthetic, psychological and moral images of the «espagnolade» for which ethnicity and gender operated as substrata that became clichés in a peripheral and fascinating Spanish culture.

    17. De novo amplification within a silent human cholinesterase gene in a family subjected to prolonged exposure to organophosphorus insecticides

      International Nuclear Information System (INIS)

      Prody, C.A.; Dreyfus, P.; Soreq, H.; Zamir, R.; Zakut, H.

      1989-01-01

      A 100-fold DNA amplification in the CHE gene, coding for serum butyrylcholinesterase (BtChoEase), was found in a farmer expressing silent CHE phenotype. Individuals homozygous for this gene display a defective serum BtChoEase and are particularly vulnerable to poisoning by agricultural organophosphorus insecticides, to which all members of this family had long been exposed. DNA blot hybridization with regional BtChoEase cDNA probes suggested that the amplification was most intense in regions encoding central sequences within BtChoEase cDNA, whereas distal sequences were amplified to a much lower extent. This is in agreement with the onion skin model, based on amplification of genes in cultured cells and primary tumors. The amplification was absent in the grandparents but present at the same extent in one of their sons and in a grandson, with similar DNA blot hybridization patterns. In situ hybridization experiments localized the amplified sequences to the long arm of chromosome 3, close to the site where the authors previously mapped the CHE gene. Altogether, these observations suggest that the initial amplification event occurred early in embryogenesis, spermatogenesis, or oogenesis, where the CHE gene is intensely active and where cholinergic functioning was indicated to be physiologically necessary. These findings demonstrate a de novo amplification in apparently healthy individuals within an autosomal gene producing a target protein to an inhibitor

    18. Prevalence of silent myocardial ischaemia during exercise stress testing. Its relation to effort tolerance and myocardial perfusion abnormalities.

      Science.gov (United States)

      Fragasso, G; Sciammarella, M G; Rossetti, E E; Xuereb, R G; Xuereb, M; Bonetti, F; Carandente, O M; Margonato, A; Chierchia, S L

      1992-07-01

      The number of underperfused myocardial segments, the extent of coronary artery disease and the severity of impairment of coronary flow reserve were compared in 147 consecutive patients exhibiting painful or painless ischaemic ST segment depression on exercise testing. Of 147 patients, only 61 (41%) experienced angina (group 1) whilst 86 (59%) did not (group 2). In the two groups coronary disease was comparable for both extent and distribution, and neither the location of transient perfusion defects nor their relation to areas of old myocardial necrosis appeared to influence the presence or absence of chest pain. However, exercise duration, exercise time and rate-pressure product at the beginning of ischaemia were lower in group 1. Furthermore, a greater proportion of asymptomatic patients had only one ischaemic segment on 99mTc-MIBI perfusion scintigraphy. We conclude that: (1) in patients with effort angina and coronary disease, the incidence of electrocardiographic silent ischaemic events induced by exercise is similar to that observed in studies based on continuous ECG monitoring. (2) Exertional angina is more frequently associated with greater ischaemic areas and with more severe degrees of impairment of residual coronary flow reserve. (3) The presence of an old myocardial infarction does not appear to influence the incidence of ischaemic cardiac pain.

    19. White Matter Damage Relates to Oxygen Saturation in Children With Sickle Cell Anemia Without Silent Cerebral Infarcts.

      Science.gov (United States)

      Kawadler, Jamie M; Kirkham, Fenella J; Clayden, Jonathan D; Hollocks, Matthew J; Seymour, Emma L; Edey, Rosanna; Telfer, Paul; Robins, Andrew; Wilkey, Olu; Barker, Simon; Cox, Tim C S; Clark, Chris A

      2015-07-01

      Sickle cell anemia is associated with compromised oxygen-carrying capability of hemoglobin and a high incidence of overt and silent stroke. However, in children with no evidence of cerebral infarction, there are changes in brain morphometry relative to healthy controls, which may be related to chronic anemia and oxygen desaturation. A whole-brain tract-based spatial statistics analysis was carried out in 25 children with sickle cell anemia with no evidence of abnormality on T2-weighted magnetic resonance imaging (13 male, age range: 8-18 years) and 14 age- and race-matched controls (7 male, age range: 10-19 years) to determine the extent of white matter injury. The hypotheses that white matter damage is related to daytime peripheral oxygen saturation and steady-state hemoglobin were tested. Fractional anisotropy was found to be significantly lower in patients in the subcortical white matter (corticospinal tract and cerebellum), whereas mean diffusivity and radial diffusivity were higher in patients in widespread areas. There was a significant negative relationship between radial diffusivity and oxygen saturation (Plevel negative relationship between radial diffusivity and hemoglobin (Pcell anemia, and provides for the first time direct evidence of a relationship between brain microstructure and markers of disease severity (eg, peripheral oxygen saturation and steady-state hemoglobin). This study suggests that diffusion tensor imaging metrics may serve as a biomarker for future trials of reducing hypoxic exposure. © 2015 American Heart Association, Inc.

    20. Theoretical Study of Methods for Improving the Energy Efficiency of NOx Removal from Diesel Exhaust Gases by Silent Discharge

      Science.gov (United States)

      Shoyama, Taiji; Yoshioka, Yoshio

      To improve the NO removal performance in silent discharge process, we investigated the influence of the physical parameters such as current density, channel radius and pulse duration of the one micro discharge under the constant reduced electric field strength. And influence of the micro discharges occurrence locations were also discussed. In order to analyze the NO removal process, we assumed that the pulse micro discharges occur repeatedly at the same location in static gas and that the chemical reactions induced by micro discharge forms many radicals, which react with pollutants and by-products. The conclusions we obtained are that lower current density, smaller discharge radius and shorter discharge duration improve NO removal efficiency. These results also mean that the lower discharge energy of the one micro discharge and the larger number of parallel micro discharges increase the NO removal performance. Therefore, to make the area of one micro discharge small is a desirable way to improve the NO removal performance. So we think that the glow like discharge might be more effective than the streamer like discharge mode. Next, using the two-dimensional model, which considered the influence of gas flow, we obtained a conclusion that the repeated micro discharges at different positions are very effective to increase the De-NOx performance. The reason is that the reaction of NO2+O→NO+O2 and ozone dissociation reactions are suppressed by the movement of the location of micro discharges.

    1. Programa nutricional dirigido a personas con riesgo cardiovascular para prevenir enfermedades cardiovasculares

      OpenAIRE

      Cano Herrero, Cristina

      2013-01-01

      El sistema cardiovascular está constituido por el corazón y los vasos sanguíneos. Su función principal es la de bombear la sangre para transportar el oxigeno y otras sustancias nutritivas hacia los tejidos y eliminar los productos residuales. Cualquier alteración del corazón y de los vasos sanguíneos conlleva a lo que se denomina enfermedades cardiovasculares (ECV). Dentro de esta gran variedad de patologías, las más comunes son la isquemia cardiaca y la enfermedad vasculocerebral (EVC) (1-3)...

    2. The Preference of Keeping the Intermediary /y/(ی in Prepositional Construction and Its Attachment to the Silent» h«.

      Directory of Open Access Journals (Sweden)

      Mohammad Irani

      2010-06-01

      Full Text Available Abstract   One of the problems of Persian writing is the question of writing and including the noun or adjective "Prepositional" construction sign in words the written form of which end in a silent » h « which is in fact a short vowel equivalent to /e/ (kasra ـِـ .The difference between the two ways of writing the intermediary consonant /y/( ی at the end of the word with a last silent » h « , completely as « ی » or with the sign « ء» on the silent » h « is rooted in the controversy between the traditional and modern approaches of writing.   The present study is about to study into the following subjects: an analysis and criticism of both the above approaches, a survey of the history of the intermediary /y/( ی , recognizing its phonetic significance and its role in making and adding new syllables, and finally a conclusion about the more convenient way to write it. It is possible that the outcome of the present study will provide us with a unique form of writing of the case in different texts like books, articles, newspapers, journals and electronic texts.

    3. Fuerza manual de adultos con discapacidad intelectual

      Directory of Open Access Journals (Sweden)

      Ruth Cabeza Ruiz

      2017-09-01

      Full Text Available Objetivo. Presentar una descripción de la fuerza de prensión manual de hombres y mujeres con discapacidad intelectual (DI y comparar los resultados con valores de referencia de otras personas con y sin discapacidad intelectual. Método. El presente trabajo es un estudio transversal observacional, financiado por la Fundación SAMU, en el que se evaluaron a 122 personas con DI (86 hombres y 36 mujeres durante el desarrollo de unas jornadas de carácter recreativo en las que participaron varias asociaciones de atención a este colectivo. La batería de test utilizada fue el Alpaha-Fit Test Battery for Adults. Resultados. Se presentan los resultados relacionados con las variables de fuerza del miembro superior (Hand Grip Strength por grupos de edad (20-24, 25- 29, 30-34, 35-39, 40-44, 45-49, 50-54, 55-59 años. Los datos muestran valores que oscilan desde los 31 kg en los hombres más jóvenes con DI hasta los 13.3 kg del grupo más maduro de mujeres. Estos hallazgos son similares a los valores de referencia de población con DI española. Sin embargo, son muy inferiores a los obtenidos por la población sin discapacidad de la misma edad. Conclusión. Los resultados evidencian el menor rendimiento de las personas con DI en pruebas de fuerza de prensión manual por lo que se hace evidente la necesidad de llevar a cabo programas de ejercicio físico o deporte con las personas con DI.

    4. Experiencias de haber crecido con un padre/madre con trastorno mental severo (TMS)

      OpenAIRE

      Vivanco B, Gabriela; Grandón F, Pamela

      2016-01-01

      Introducción. La experiencia de vivir con personas que presentan un Trastorno Mental Severo (TMS) es difícil para las familias, en especial para los hijos quienes han sido poco estudiados. El objetivo de la investigación fue conocer cómo la experiencia de haber vivido con un padre o madre con un trastorno mental severo influyó en la infancia, adolescencia y adultez joven de sus hijos e hijas. Método. Se analizan las experiencias de convivencia con un padre/madre con TMS en 10 hijos (6 hombres...

    5. Correlating lesion size and location to deficits after ischemic stroke: the influence of accounting for altered peri-necrotic tissue and incidental silent infarcts

      Directory of Open Access Journals (Sweden)

      Black Sandra E

      2010-01-01

      Full Text Available Abstract Background Investigators frequently quantify and evaluate the location and size of stroke lesions to help uncover cerebral anatomical correlates of deficits observed after first-ever stroke. However, it is common to discover silent infarcts such as lacunes in patients identified clinically as 'first-ever' stroke, and it is unclear if including these incidental findings may impact lesion-based investigations of brain-behaviour relationships. There is also debate concerning how to best define the boundaries of necrotic stroke lesions that blend in an ill-defined way into surrounding tissue, as it is unclear whether including this altered peri-necrotic tissue region may influence studies of brain-behaviour relationships. Therefore, for patients with clinically overt stroke, we examined whether including altered peri-necrotic tissue and incidental silent strokes influenced either lesion volume correlations with a measure of sensorimotor impairment or the anatomical localization of this impairment established using subtraction lesion analysis. Methods Chronic stroke lesions of 41 patients were manually traced from digital T1-MRI to sequentially include the: necrotic lesion core, altered peri-necrotic tissue, silent lesions in the same hemisphere as the index lesion, and silent lesions in the opposite hemisphere. Lesion volumes for each region were examined for correlation with motor impairment scores, and subtraction analysis was used to highlight anatomical lesion loci associated with this deficit. Results For subtraction lesion analysis, including peri-necrotic tissue resulted in a larger region of more frequent damage being seen in the basal ganglia. For correlational analysis, only the volume of the lesion core was significantly associated with motor impairment scores (r = -0.35, p = 0.025. In a sub-analysis of patients with small subcortical index lesions, adding silent lesions in the opposite hemisphere to the volume of the index

    6. El maltrato en las personas con discapacidad

      OpenAIRE

      Revuelta, Lucerga

      2014-01-01

      El maltrato no solo se realiza por acción sino también por omisión, la indiferencia hacia la persona con discapacidad es una forma de maltrato muy frecuente. Por ejemplo, ignorar y desatender las necesidades de la persona con discapacidad o, al contrario, la sobreprotección son maneras de maltrato. Cuando a un niño con discapacidad el padre o cuidador le hace todo, el niño se siente agredido pues le están incapacitando más de lo que su enfermedad ya lo hace.

    7. Hiperalgesia asociada al tratamiento con opioides

      OpenAIRE

      A. Gil Martín; M. Moreno García; J. Sánchez-Rubio Ferrández; T. Molina García

      2014-01-01

      La hiperalgesia inducida por opioides es una reacción paradójica caracterizada por una percepción intensificada de dolor relacionada con el uso de estos medicamentos en ausencia de progresión de la enfermedad o de síndrome de retirada. A diferencia de los casos de tolerancia, definida como pérdida de potencia analgésica durante el uso prolongado de opioides, no se produce mejoría con el escalado de dosis. La hiperalgesia inducida por opioides se ha manifestado en pacientes con dosis de manten...

    8. Tratamiento conservador en pacientes con retinoblastoma bilateral

      Directory of Open Access Journals (Sweden)

      Juan C. Suárez

      2008-11-01

      Full Text Available OBJETIVO: comparar el tratamiento convencional del retinoblastoma bilateral, usado hasta hace algunos años, consistente en radioterapia o enucleación bilateral, con el tratamiento conservador actual que incluye termoterapia transpupilar (TTT o TTT/quimioterapia al menos en un ojo, en niños con diagnóstico de retinoblastoma bilateral. DISEÑO: estudio retrospectivo descriptivo. MUESTRA: 20 pacientes con diagnóstico de retinoblastoma bilateral que consultaron al Hospital Universitario San Vicente de Paúl, de Medellín, Colombia, entre 1997 y 2007. MÉTODO: se hizo enucleación del ojo con el tumor de mayor tamaño. En el otro ojo se hizo tratamiento con TTT, con el láser diodo (810 nm, spot amplio, solo o combinado con otras terapias. RESULTADOS: se dividió a los pacientes en dos grupos: 16 pacientes (32 ojos en el grupo 1 tratados conservadoramente y 4 pacientes (8 ojos en el grupo 2 con tratamiento convencional. El rango de edad fue de 1-72 meses en el grupo 1 y de 1-12 meses en el grupo 2. El tiempo de seguimiento fue de 7-67 meses para el grupo 1 y de 13-73 meses para el grupo 2. En el grupo 1 se hizo enucleación de 16 ojos (50%, radioterapia externa de uno (3,1%, quimioterapia más termoterapia de 5 (15,6% y quimioterapia más termoterapia más crioterapia de 10 (31,3%. En todos los pacientes se logró preservar al menos un ojo. En el grupo 2, se enuclearon 7 ojos (87,5% y se hizo radioterapia externa más enucleación en un paciente (12.5%. Además, todos los pacientes recibieron quimioterapia. CONCLUSIÓN: la terapia conservadora actual consistente en tratamiento local (termoterapia, crioterapia o braquiterapia y quimiorreducción permite preservar al menos un ojo y en algunos casos de los dos, muchas veces con buena agudeza visual, en niños con retinoblastoma bilateral; se evitan así la enucleación bilateral y la radioterapia externa usada en el tratamiento convencional con todos sus efectos secundarios. La enucleación contin

    9. Paciente con tumor de cuerpo carotideo

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      Mariuska Forteza Sáez

      Full Text Available Los tumores de cuerpo carotideo (paragangliomas son neoplasias altamente vascularizadas, muy poco frecuentes y generalmente benignas, originadas en los quimiorreceptores del cuerpo carotideo. Se presenta el caso de un paciente de 54 años, con aumento de volumen cervical derecho, asintomático, con estudio preoperatorio y angiografía realizados por tomografía axial computarizada, que resultan compatibles con tumor de cuerpo carotideo. Se realiza disección subadventicial, informando la biopsia paraganglioma. El tumor fue completamente resecado, sin evidencia de recurrencia y sin complicaciones.

    10. Prevalence of silent fecal and urinary incontinence in women from the town of Teruel Prevalencia de la incontinencia anal y urinaria silentes en mujeres de la ciudad de Teruel

      Directory of Open Access Journals (Sweden)

      A. Ballester

      2005-02-01

      Full Text Available Objectives: to study the prevalence of fecal (FI and urinary incontinence (UI in women from Teruel (Spain, as well as the clinical conditions associated with these disorders. Methods: we studied prospectively women with an age range of 20-64 yrs. who were randomly selected from the population seen in a primary care center because of medical disorders not related to incontinence. Patients with functional or cognitive impairment were excluded. Medical and obstetric antecedents, as well as the type and frequency of incontinence symptoms were collected in a questionnaire. Results: out of 115 women, 103 completed the study (mean age: 41±12 yrs. range 20-64. UI was present in 34.9% (stress 33%, urge 14%, mixed 47%, FI in 14 (13.6% (flatus 57%, liquid stools 43%, and 10 (9.7% displayed both disorders. Age > 42 yr. and body mass index ≥ 25 were associated with FI and UI; pregnancy was only associated with UI, but the group of women with ≥ 2 vaginal deliveries showed a higher frequency of FI (p Objetivos: conocer la prevalencia de la incontinencia anal (IA y urinaria (IU, así como los factores asociados, en mujeres con capacidad social autónoma en la ciudad de Teruel. Métodos: estudio prospectivo aleatorizado en 115 mujeres (20-64 años que acudieron a un centro de asistencia primaria por motivos independientes de IA o IU, sin alteraciones físicas ni psíquicas que pudieran condicionar la existencia de incontinencia. Resultados: completaron el estudio 103 mujeres (89,5%: 34,9% presentaban IU (33% de esfuerzo, 14% de urgencia y 47% mixta; 14 (13,6% referían IA (57% a gases y 42,9% a heces líquidas y 10 (9,7% presentaban IA e IU. En el análisis univariante, la edad > 42 años y el índice de masa corporal > 25 se asocian con la IA y con la IU; la existencia de embarazos a término, con la IU, y la existencia de dos o más partos vaginales se correlaciona con la IA (p < 0,05. La IA se relaciona con la presencia de IU (OR 6,0; IC 95%: 1

    11. [Silent myocardial ischemia and exercise-induced arrhythmia detected by the exercise test in the total health promotion plan (THP)].

      Science.gov (United States)

      Iwane, M; Shibe, Y; Itoh, K; Kinoshita, F; Kanagawa, Y; Kobayashi, M; Mugitani, K; Ohta, M; Ohata, H; Yoshikawa, A; Ikuta, Z; Nakamura, Y; Mohara, O

      2001-03-01

      We investigated the prevalence and characteristics of ischemic heart disease especially silent myocardial ischemia (SMI) and arrhythmia in need of careful observation in the exercise stress tests in the Total Health Promotion Plan (THP), which was conducted between 1994-96 for the purpose of measuring cardiopulmonary function. All workers (n = 4,918, 4,426 males) aged 18-60 yr old in an occupational field were studied. Exercise tests with an ergometer were performed by the LOPS protocol, in which the maximal workload was set up as a presumed 70-80% maximal oxygen intake, or STEP (original multistage protocol). ECG changes were evaluated with a CC5 lead. Two hundred and fifteen people refused the study because of a common cold, lumbago and so on. Of 4,703 subjects, 17 with abnormal rest ECG and 19 with probable anginal pain were excluded from the exercise tests. Of 4,667 who underwent the exercise test, 37 (0.79%) had ischemic ECG change, and 155 (3.32%) had striking arrhythmia. These 228 subjects then did a treadmill exercise test with Bruce protocol. Twenty-two (0.47% of 4,703) showed positive ECG change, 9 (0.19%) of 22 had abnormal findings on a 201Tl scan. 8 (0.17%) were diagnosed as SMI (Cohn I), in which the prevalence of hypertension, hyperlipidemia, diabetes mellitus, smoker and positive familial history of ischemic heart disease was greater than that of all subjects. In a 15-30 month follow up, none has developed cardiac accidents. Exercise-induced arrhythmia was detected in 11 (0.23%) subjects. Four were non-sustained ventricular tachycardia without any organic disease, 4 were ventricular arrhythmia based on cardiomyopathy detected by echocardiography, 2 were atrial fibrillation and another was WPW syndrome. It is therefore likely that the ergometer exercise test in THP was effective in preventing sudden death caused by ischemic heart disease or striking arrhythmia.

    12. AUTOPSY-BASED STUDY OF SILENT LIVER DISEASES IN MEDICOLEGAL CASES IN A TERTIARY CARE CENTRE OF EASTERN ODISHA

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      Bidyut Prava Das

      2017-05-01

      Full Text Available BACKGROUND An autopsy is a medical procedure that consists of a thorough examination of corpse to determine the cause of death and to evaluate any diseases that maybe present. Most of the chronic liver diseases even in advanced stages may cause no signs and symptoms and may go undiagnosed or are found coincidently during general health checkup, investigation being done for some other disease, surgery or autopsy. The underlying cause of chronic liver diseases vary in different geographic areas and are based on various factors such as socioeconomic status, lifestyle, diet, local and other endemic diseases. Hence, we have conducted this study to unearth the silent liver diseases in medicolegal cases. MATERIALS AND METHODS The study was carried out in Department of Pathology and Forensic Medicine and Toxicology of SCB Medical College, Cuttack, during 2012 to 2015. All medicolegal cases received for autopsy are included in the study. Routine HE stain and special stain like reticulin, Masson trichrome stain was used wherever necessary and results were analysed. RESULTS Autopsy was done in 139 cases. Portal inflammation and fibrosis was found in 35 (25.18% cases. Sinusoidal dilatation and congestion in 29 cases (20.86%, cirrhosis and bridging fibrosis was found in 16 cases (11.5%, steatohepatitis in 27 cases (19.42%, cholestasis in 3 cases (2.16%, hepatitis 1 case (0.72% and hepatocellular carcinoma in 1 case (0.72%. The others include autolytic changes and normal liver. CONCLUSION Autopsy and histopathological study of liver is the best method to determine the clinically latent liver diseases.

    13. Variation of poorly ventilated lung units (silent spaces) measured by electrical impedance tomography to dynamically assess recruitment.

      Science.gov (United States)

      Spadaro, Savino; Mauri, Tommaso; Böhm, Stephan H; Scaramuzzo, Gaetano; Turrini, Cecilia; Waldmann, Andreas D; Ragazzi, Riccardo; Pesenti, Antonio; Volta, Carlo Alberto

      2018-01-31

      Assessing alveolar recruitment at different positive end-expiratory pressure (PEEP) levels is a major clinical and research interest because protective ventilation implies opening the lung without inducing overdistention. The pressure-volume (P-V) curve is a validated method of assessing recruitment but reflects global characteristics, and changes at the regional level may remain undetected. The aim of the present study was to compare, in intubated patients with acute hypoxemic respiratory failure (AHRF) and acute respiratory distress syndrome (ARDS), lung recruitment measured by P-V curve analysis, with dynamic changes in poorly ventilated units of the dorsal lung (dependent silent spaces [DSSs]) assessed by electrical impedance tomography (EIT). We hypothesized that DSSs might represent a dynamic bedside measure of recruitment. We carried out a prospective interventional study of 14 patients with AHRF and ARDS admitted to the intensive care unit undergoing mechanical ventilation. Each patient underwent an incremental/decremental PEEP trial that included five consecutive phases: PEEP 5 and 10 cmH 2 O, recruitment maneuver + PEEP 15 cmH 2 O, then PEEP 10 and 5 cmH 2 O again. We measured, at the end of each phase, recruitment from previous PEEP using the P-V curve method, and changes in DSS were continuously monitored by EIT. PEEP changes induced alveolar recruitment as assessed by the P-V curve method and changes in the amount of DSS (p Recruited volume measured by the P-V curves significantly correlated with the change in DSS (r s  = 0.734, p recruitment measured using the P-V curve technique. EIT might provide useful information to titrate personalized PEEP. ClinicalTrials.gov, NCT02907840 . Registered on 20 September 2016.

    14. Altered myocardial perfusion during dobutamine stress testing in silent versus symptomatic myocardial ischaemia assessed by quantitative MIBI SPET imaging

      International Nuclear Information System (INIS)

      Elhendy, A.; Geleijnse, M.L.; Roelandt, J.R.T.C.; Cornel, J.H.; Domburg, R.T van; Reijs, A.E.M.; Nierop, P.R.; Fioretti, P.M.

      1996-01-01

      The aim of the study was to compare the extent and severity of reversible underperfusion in silent versus painful myocardial ischaemia during the dobutamine stress test. A consecutive series of 85 patients with significant coronary artery disease and reversible perfusion defects on technetium-99m methoxyisobutylisonitrile single-photon emission tomography performed at rest and during high-dose dobutamine stress (up to 40 μg kg -1 min -1 ) were studied. The left ventricle was divided into six segments. An ischaemic perfusion score was derived quantitatively by subtracting the rest from the stress defect score. Patients with multivessel disease had a higher ischaemic score (610±762 vs 310±411, P<0.05) and a higher number of reversible perfusion defects (2.1±1.2 vs 1.1±0.8, P<0.01) than patients with single-vessel disease. Typical angina occurred in 37 patients (44%) during the test. There was no significant difference between patients with and patients without angina with respecft to age, gender, peak rate-pressure product, prevalence of previous myocardial infarction, diabetes mellitus, multivessel disease or number of stenotic coronary arteries. Stress, rest and ischaemic scores as well as the number and distribution of reversible defects were not different in patients with and patients without angina. Patients with angina more frequently had a history of typical angina before the test (43% vs 17%, P<0.01) and ST-segment depression during the test (54% vs 25%, P<0.01). It is concluded that in patients with coronary artery disease and ischaemia detected by dobutamine scintigraphy, the extent and severity of coronary artery disease and myocardial perfusion abnormalities are similar with or without angina during stess testing. (orig.)

    15. Sildenafil protects against bile duct ligation induced hepatic fibrosis in rats: Potential role for silent information regulator 1 (SIRT1).

      Science.gov (United States)

      Abd El Motteleb, Dalia M; Ibrahim, Islam A A E-H; Elshazly, Shimaa M

      2017-11-15

      Hepatic fibrosis is a potential health problem that may end with life-threatening cirrhosis and primary liver cancer. Recent studies point out to the protective effects of silent information regulator1 (SIRT1), against different models of organs fibrosis. This work aimed to investigate the possible protective effect of sildenafil (SIRT1 activator) against hepatic fibrosis induced by bile duct ligation (BDL). Firstly, three different doses of sildenafil (5, 10, 20mg/kg/day) were investigated; to detect the most protective one against BDL induced liver dysfunction and hepatic fibrosis. The most protective dose is then used; to study its effect on BDL induced SIRT1 downregulation, imbalance of oxidant/antioxidant status, increased inflammatory cytokines and fibrosis. Sildenafil (20mg/kg/day) was the most protective one, it caused upregulation of SIRT1, reduction of hepatic malondialdehyde (MDA) content, increase in expression of nuclear factor erythroid 2-related factor 2 (Nrf2), hemeoxygenease (HO)-1, reduced glutathione (GSH) content and superoxide dismutase (SOD) activity. Hepatic content of tumor necrosis factor-α (TNF-α) and nuclear factor κB (NFκB) expression & content displayed significant reductions with sildenafil treatment, Furthermore, sildenafil caused marked reductions of transforming growth factor (TGF)-β content, expression of plasminogen activator inhibitor-1 (PAI-1), matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), α-smooth muscle actin (α-SMA), fibronectin, collagen I (α1) and hydroxyproline content. However, sildenafil protective effects were significantly reduced by co-administration of EX527 (SIRT1 inhibitor). Our work showed, for the first time that, sildenafil has promising protective effects against BDL induced liver dysfunction and hepatic fibrosis. These effects may be, in part, mediated by up regulation of SIRT1. Copyright © 2017. Published by Elsevier Inc.

    16. Neuronal SIRT1 (Silent Information Regulator 2 Homologue 1) Regulates Glycolysis and Mediates Resveratrol-Induced Ischemic Tolerance.

      Science.gov (United States)

      Koronowski, Kevin B; Khoury, Nathalie; Saul, Isabel; Loris, Zachary B; Cohan, Charles H; Stradecki-Cohan, Holly M; Dave, Kunjan R; Young, Juan I; Perez-Pinzon, Miguel A

      2017-11-01

      Resveratrol, at least in part via SIRT1 (silent information regulator 2 homologue 1) activation, protects against cerebral ischemia when administered 2 days before injury. However, it remains unclear if SIRT1 activation must occur, and in which brain cell types, for the induction of neuroprotection. We hypothesized that neuronal SIRT1 is essential for resveratrol-induced ischemic tolerance and sought to characterize the metabolic pathways regulated by neuronal Sirt1 at the cellular level in the brain. We assessed infarct size and functional outcome after transient 60 minute middle cerebral artery occlusion in control and inducible, neuronal-specific SIRT1 knockout mice. Nontargeted primary metabolomics analysis identified putative SIRT1-regulated pathways in brain. Glycolytic function was evaluated in acute brain slices from adult mice and primary neuronal-enriched cultures under ischemic penumbra-like conditions. Resveratrol-induced neuroprotection from stroke was lost in neuronal Sirt1 knockout mice. Metabolomics analysis revealed alterations in glucose metabolism on deletion of neuronal Sirt1 , accompanied by transcriptional changes in glucose metabolism machinery. Furthermore, glycolytic ATP production was impaired in acute brain slices from neuronal Sirt1 knockout mice. Conversely, resveratrol increased glycolytic rate in a SIRT1-dependent manner and under ischemic penumbra-like conditions in vitro. Our data demonstrate that resveratrol requires neuronal SIRT1 to elicit ischemic tolerance and identify a novel role for SIRT1 in the regulation of glycolytic function in brain. Identification of robust neuroprotective mechanisms that underlie ischemia tolerance and the metabolic adaptations mediated by SIRT1 in brain are crucial for the translation of therapies in cerebral ischemia and other neurological disorders. © 2017 American Heart Association, Inc.

    17. Interferon β protects against avascular osteonecrosis through interleukin 6 inhibition and silent information regulator transcript-1 upregulation.

      Science.gov (United States)

      Kim, Kyoung Min; Wagle, Sajeev; Moon, Young Jae; Wang, Sung Il; Park, Byung-Hyun; Jang, Kyu Yun; Kim, Jung Ryul

      2018-01-09

      Synovitis of the affected joint is a common in avascular osteonecrosis (AVN). Increased levels of pro-inflammatory cytokine interleukin-6 (IL-6) have been reported in AVN, but the mechanism of this increase remains unclear. Silent information regulator transcript-1 (SIRT1), an NAD-dependent deacetylase, inhibits the release of inflammatory cytokines. Interferon β (IFN-β) has clear anti-inflammatory properties. We sought to investigate the effects of IFN-β treatment on AVN and to evaluate the specific signal pathway relating to IL-6 and SIRT1 affected during AVN. Using a dissection microscope, AVN was surgically induced in the distal femurs of mice. Exogenous IFN-β was administered to the model mice. The effects of exogenous IFN-β on AVN model mice were assessed using hematoxylin eosin and safranin-O staining, and bone resorption activity was measured using tartrate-resistant acid phosphatase (TRAP) and CD68 staining. Western blots, real-time RT-PCR, and immunohistochemical staining were performed to evaluate the production of SIRT1 and IL-6 in tissues. The RAW 264.7 cell line and bone marrow derived osteoclasts treated with exogenous IFN-β. Histological findings indicated well preserved trabecular bone and decreased osteoclast bone resorption activity in IFN-β treated mice compared with mice in the AVN group. Treatment with IFN-β increased SIRT1 expression and inhibited secretion of IL-6 in this AVN mouse model. IFN-β decreased IL-6 secretion by activating SIRT1 in the RAW 264.7 cell and bone marrow derived osteoclasts. Our work suggests that IFN-β could be used to treat AVN and that both SIRT1 and IL-6 are useful targets for treating patients with AVN.

    18. Many Neighbors are not Silent. fMRI Evidence for Global Lexical Activity in Visual Word Recognition.

      Directory of Open Access Journals (Sweden)

      Mario eBraun

      2015-07-01

      Full Text Available Many neurocognitive studies investigated the neural correlates of visual word recognition, some of which manipulated the orthographic neighborhood density of words and nonwords believed to influence the activation of orthographically similar representations in a hypothetical mental lexicon. Previous neuroimaging research failed to find evidence for such global lexical activity associated with neighborhood density. Rather, effects were interpreted to reflect semantic or domain general processing. The present fMRI study revealed effects of lexicality, orthographic neighborhood density and a lexicality by orthographic neighborhood density interaction in a silent reading task. For the first time we found greater activity for words and nonwords with a high number of neighbors. We propose that this activity in the dorsomedial prefrontal cortex reflects activation of orthographically similar codes in verbal working memory thus providing evidence for global lexical activity as the basis of the neighborhood density effect. The interaction of lexicality by neighborhood density in the ventromedial prefrontal cortex showed lower activity in response to words with a high number compared to nonwords with a high number of neighbors. In the light of these results the facilitatory effect for words and inhibitory effect for nonwords with many neighbors observed in previous studies can be understood as being due to the operation of a fast-guess mechanism for words and a temporal deadline mechanism for nonwords as predicted by models of visual word recognition. Furthermore, we propose that the lexicality effect with higher activity for words compared to nonwords in inferior parietal and middle temporal cortex reflects the operation of an identification mechanism and based on local lexico-semantic activity.

    19. Chronic and acute anemia and extracranial internal carotid stenosis are risk factors for silent cerebral infarcts in sickle cell anemia.

      Science.gov (United States)

      Bernaudin, Françoise; Verlhac, Suzanne; Arnaud, Cécile; Kamdem, Annie; Vasile, Manuela; Kasbi, Florence; Hau, Isabelle; Madhi, Fouad; Fourmaux, Christine; Biscardi, Sandra; Epaud, Ralph; Pondarré, Corinne

      2015-03-05

      Early transcranial Doppler (TCD) screening of the Créteil sickle cell anemia (SCA)-newborn cohort, and rapid initiation of transfusion programs, resulted in successful prevention of overt strokes, but a high cumulative risk of silent cerebral infarcts (SCI) remained, suggesting that TCD screening does not identify all patients with SCA at risk for SCI. We hypothesized that episodes of hypoperfusion/hypoxia, as observed during acute chest syndromes or acute anemic events (AAE), and extracranial internal carotid artery (eICA) stenoses, detectable via submandibular Doppler sonography and cervical magnetic resonance angiography (MRA), could also be risk factors for SCI. This study includes 189 stroke-free patients with SCA from the Créteil newborn cohort (1992-2010) followed longitudinally by magnetic resonance imaging/MRA, including cervical MRA at the last assessment. All patients with abnormal TCD and/or intracranial stenoses were placed on a transfusion program. Mean follow-up was 9.9 years (range, 2.2-19.9 years; 1844 patient-years). Annual rates of clinical events were calculated. The cumulative risk for SCI was 39.1% (95% confidence interval [CI], 23.5%-54.7%) by age 18 years, with no plateau. We confirm that baseline hemoglobin level lower than 7 g/dL before age 3 years is a highly significant predictive risk factor for SCI (hazard ratio, 2.97; 95% CI, 1.43-6.17; P = .004). Furthermore, we show that AAE rate (odds ratio, 2.64 per unit increase; 95% CI, 1.09-6.38; P = .031) and isolated eICA stenosis (odds ratio, 3.19; 95% CI, 1.18-8.70; P = .023) are significant and independent risk factors for SCI. © 2015 by The American Society of Hematology.

    20. Presa con revestimiento asfáltico

      Directory of Open Access Journals (Sweden)

      Proudfit, D. P.

      1960-07-01

      Full Text Available La presa denominada Montgomery se halla situada sobre el río South Platte River, a unos 8 km aguas arriba de la ciudad de Alma, del Estado de Colorado (EE. UU., y en la ladera oriental de la cordillera Continental Divide. El cuerpo o dique de esta presa está constituido por piedra, revestida con una capa de hormigón asfáltico en el paramento de contacto con el agua.

    1. Trastornos temporomandibulares en pacientes con maloclusiones

      Directory of Open Access Journals (Sweden)

      Luis Soto Cantero

      Full Text Available Introducción: existe una prevalencia de trastornos oclusales en gran medida relacionados con la presencia de disfunción temporomandibular. Objetivo: determinar el grado de disfunción temporomandibular según el Índice de Maglione en correspondencia con la prevalencia de maloclusiones en el área de salud del policlínico "Turcios Lima". Métodos: se realizó un estudio observacional descriptivo, de corte transversal, en la consulta de ortodoncia, de junio del 2008 a junio del 2009. De un universo constituido por los 280 pacientes que acudieron al servicio de ortodoncia en el período señalado con presencia de maloclusiones, se seleccionó una muestra de 84 pacientes por muestreo aleatorio simple, teniendo en cuenta los criterios de inclusión y exclusión realizados por criterios de expertos. Resultados: presentaban disfunción temporomandibular 74 pacientes y dentro de ellos 44 (52,4 % tenían disfunción grado II (Moderada. El 97 % de los pacientes con relación molar de clase II, presentaban disfunción temporomandibular. El 42,9 % de los pacientes con una maloclusión, presentaban disfunción grado I. El 60 % de los pacientes con dos maloclusiones presentaban disfunción grado II y el 66,7 % de los pacientes con tres maloclusiones, presentaban disfunción grado III. La mayor cantidad de pacientes tuvieron disfunción grado II (Moderada. Conclusiones: el mayor por ciento de los pacientes con disfunciones presentó una clase II molar y a medida que aumentó el número de maloclusiones aumentó también la severidad de la disfunción.

    2. RadCon: A Radiological Consequences Model

      International Nuclear Information System (INIS)

      Crawford, J.; Domel, R.U.

      2000-05-01

      RadCon estimates the dose received by user selected groups in the population from an accidental release of radionuclides to the environment. The exposure pathways considered are external exposure from the cloud and ground and internal exposure from inhalation and ingestion of contaminated food. Atmospheric dispersion modelling is carried out externally to RadCon.Given a two dimensional time varying air and ground concentration of radioactive elements, RadCon allows the user to: view the air and ground concentration over the affected area, select optional parameters and calculate the dose to people,display the results to the user, and change the parameter values. RadCon offers two user interfaces: 1) the standard graphical user interface which is started using Java DoseApp at the command line, or by setting up a shortcut to this command (particularly when RadCon is installed on a PC) and 2) the text based interface used to generate information for the model inter-comparison exercise . This is initiated using Java BIOMASS at the command line, or an equivalent shortcut. The text based interface was developed for research purposes and is not generally available. Appendices A, B and C provide a summary of instructions on setting up RadCon. This will generally be carried out by the computer support personnel

    3. Adolescente femenino con granulomatosis de Wegener fulminante

      Directory of Open Access Journals (Sweden)

      S C Scheffler-Mendoza

      2017-01-01

      Full Text Available Adolescente femenino de 13 años de edad, originaria de Guerrero, grupo étnico mixteco, padres analfabetos y con poco entendimiento del español. Sin otros antecedentes de importancia para el padecimiento. Inició un mes previo con la aparición de una pápula hipercrómica en párpado superior derecho que en los 10 días previos al ingreso aumentó de volumen generando proptosis. Al interrogatorio se negó dolor, lagrimeo, fiebre, o pérdida de peso. Ingresó con fiebre (39.0°C, palidez generalizada, proptosis derecha con exposición de córnea y conjuntiva, eritema periorbitario, movimientos oculares y agudeza visual disminuidos (i.e. contaba dedos a 1 m, pupila con tendencia a midriasis, hiperreactividad a la luz, y fondo de ojo con papila hiperémica edematosa y tortuosidad peripapilar. El resto de exploración no mostró datos relevantes. Se hospitalizó para iniciar tratamiento antimicrobiano parenteral de amplio espectro (i.e. ceftriaxona y vancomicina y abordar proptosis unilateral.

    4. Neuroprotección en la encefalopatia hipóxico isquémica perinatal: Tratamientos con eficacia clínica demostrada y perspectivas futuras Neuroprotection in perinatal hypoxic-ischemic encephalopathy: Effective treatment and future perspectives

      Directory of Open Access Journals (Sweden)

      Agustín Legido

      2007-01-01

      Full Text Available El objetivo de este trabajo es revisar el resultado de estudios clínicos recientes que han demostrado el efecto neuroprotector de algunas terapias en la encefalopatía hipóxico-isquémica (EHI perinatal y presentar las perspectivas futuras de otras investigaciones clínicas y experimentales. Terapias con eficacia clínica demostrada. Alopurinol: Bloquea la producción de radicales libres tras hipoxia-isquemia. En un estudio reciente, los niños con corazón izquierdo hipoplásico tratados con alopurinol, pero no aquéllos con otras cardiopatías, tuvieron un número significativamente menor de complicaciones que los controles, incluyendo muerte, convulsiones, coma o problemas cardíacos. Opiáceos: En otro estudio reciente, un grupo de recién nacidos con EHI tratados con morfina o fentanil tuvieron un grado menor de lesión cerebral en la RMN y un mejor pronóstico neurológico. Hipotermia: Tanto la hipotermia localizada (cerebral como la sistémica (todo el cuerpo tienen un efecto neuroprotector en recién nacidos seleccionados tras sufrir EHI. Perspectivas Futuras. Fármacos antiepilépticos. Estos tienen mecanismos de acción múltiple que pueden bloquear la cascada bioquímica de lesión neuronal en EHI. Otras modalidades terapéuticas. Entre ellas hay que destacar el estudio de la terapia neuroprotectora combinada, los factores de crecimiento, la terapia genética, el transplante de células madre y la vacunación neuroprotectora. En conclusión, un mejor conocimiento de los mecanismos moleculares de la patogenia de la EHI y mejores estudios clínicos con terapias neuroprotectoras abrirá nuevas posibilidades terapéuticas aplicables en la práctica clínica. Todo ello mejorará sin lugar a duda el pronóstico de los recién nacidos con EHI.The aim of this paper is to review the results of recent clinical studies of some therapies that have demonstrated a neuroprotective effect in perinatal hypoxic-ischemic encephalopathy (HIE and to

    5. RadConEd: A Graphical Data Editor for the Radiological Consequences Model, RadCon

      International Nuclear Information System (INIS)

      Crawford, J.; Domel, R.U.

      2000-05-01

      This document describes the application, RadConEd, which has been designed and implemented to enable users of the RadCon system to update these parameter files. The RadCon system is written in the Java programming language, and as such provides portability across computer platforms. The software described in this report was developed in line with the portability requirements of RadCon, thus providing a uniform user interface across computer platforms and bypassing the need of using system editors. In addition a number of data integrity measures were implemented

    6. Enfermedad coronaria en pacientes con psoriasis

      Directory of Open Access Journals (Sweden)

      Walter Masson

      2013-10-01

      Full Text Available Comunicaciones previas asociaron la psoriasis con la enfermedad coronaria. Desconocemos si en nuestro país o región existe dicha asociación. Se realizó un estudio transversal analizando los datos de la historia clínica electrónica de un sistema de salud de Buenos Aires. Analizamos todos los pacientes mayores de 18 años con diagnóstico de psoriasis entre el 1 de enero de 2003 y el 31 de julio de 2011 y los comparamos con un grupo control, en una relación 2:1, obtenido en forma aleatoria del mismo sistema de salud, apareados por edad y sexo. Determinamos la prevalencia de los factores de riesgo cardiovascular y de enfermedad coronaria. Analizamos la asociación entre la enfermedad coronaria y la psoriasis mediante análisis uni y multivariado. Se incluyeron 3 833 sujetos (1 286 pacientes con psoriasis y 2 547 controles. La prevalencia de hipertensión arterial (50% vs. 38%, p < 0.001, tabaquismo (25% vs. 17%, p < 0.001, diabetes (12% vs. 8%, p < 0.001 y enfermedad coronaria (4.98% vs. 3.06%, p = 0.003 fue mayor en los sujetos con psoriasis en comparación con el grupo control. Independientemente de la edad, la presencia de diabetes, hipertensión arterial o tabaquismo, hubo una asociación significativa entre la enfermedad coronaria y la psoriasis (OR 1.48, IC95% 1.04-2.11, p = 0.03. En conclusión, en esta población de Buenos Aires, los pacientes con psoriasis tuvieron una mayor prevalencia de diabetes, hipertensión arterial, tabaquismo y enfermedad coronaria. La asociación entre la psoriasis y la enfermedad coronaria fue independiente de los factores de riesgo explorados.

    7. Mincle Signaling Promotes Con-A Hepatitis

      Science.gov (United States)

      Greco, Stephanie H.; Torres-Hernandez, Alejandro; Kalabin, Aleksandr; Whiteman, Clint; Rokosh, Rae; Ravirala, Sushma; Ochi, Atsuo; Gutierrez, Johana; Salyana, Muhammad Atif; Mani, Vishnu R.; Nagaraj, Savitha V.; Deutsch, Michael; Seifert, Lena; Daley, Donnele; Barilla, Rocky; Hundeyin, Mautin; Nikifrov, Yuriy; Tejada, Karla; Gelb, Bruce E.; Katz, Steven C.; Miller, George

      2016-01-01

      Concanavalin-A (Con-A) hepatitis is regarded as a T cell-mediated model of acute liver injury. Mincle is a C-type lectin receptor (CLR) that is critical in the immune response to mycobacteria and fungi, but does not have a well-defined role in pre-clinical models of non-pathogen mediated inflammation. Since Mincle can ligate the cell death ligand SAP130, we postulated that Mincle signaling drives intrahepatic inflammation and liver injury in Con-A hepatitis. Acute liver injury was assessed in the murine Con-A hepatitis model using C57BL/6, Mincle−/−, and Dectin-1−/− mice. The role of C/EBPβ and HIF-1α signaling was assessed using selective inhibitors. We found that Mincle was highly expressed in hepatic innate inflammatory cells and endothelial cells in both mice and humans. Furthermore, sterile Mincle ligands and Mincle signaling intermediates were increased in the murine liver in Con-A hepatitis. Most significantly, Mincle deletion or blockade protected against Con-A hepatitis whereas Mincle ligation exacerbated disease. Bone marrow chimeric and adoptive transfer experiments suggested that Mincle signaling in infiltrating myeloid cells dictates disease phenotype. Conversely, signaling via other CLRs did not alter disease course. Mechanistically, we found that Mincle blockade decreased the NF-κβ related signaling intermediates, C/EBPβ and HIF-1α, both of which are necessary in macrophage-mediated inflammatory responses. Accordingly, Mincle deletion lowered production of nitrites in Con-A hepatitis and inhibition of both C/EBPβ and HIF1-α reduced the severity of liver disease. Our work implicates a novel innate immune driver of Con-A hepatitis and, more broadly, suggests a potential role for Mincle in diseases governed by sterile inflammation. PMID:27559045

    8. Mincle Signaling Promotes Con A Hepatitis.

      Science.gov (United States)

      Greco, Stephanie H; Torres-Hernandez, Alejandro; Kalabin, Aleksandr; Whiteman, Clint; Rokosh, Rae; Ravirala, Sushma; Ochi, Atsuo; Gutierrez, Johana; Salyana, Muhammad Atif; Mani, Vishnu R; Nagaraj, Savitha V; Deutsch, Michael; Seifert, Lena; Daley, Donnele; Barilla, Rocky; Hundeyin, Mautin; Nikifrov, Yuriy; Tejada, Karla; Gelb, Bruce E; Katz, Steven C; Miller, George

      2016-10-01

      Con A hepatitis is regarded as a T cell-mediated model of acute liver injury. Mincle is a C-type lectin receptor that is critical in the immune response to mycobacteria and fungi but does not have a well-defined role in preclinical models of non-pathogen-mediated inflammation. Because Mincle can ligate the cell death ligand SAP130, we postulated that Mincle signaling drives intrahepatic inflammation and liver injury in Con A hepatitis. Acute liver injury was assessed in the murine Con A hepatitis model using C57BL/6, Mincle(-/-), and Dectin-1(-/-) mice. The role of C/EBPβ and hypoxia-inducible factor-1α (HIF-1α) signaling was assessed using selective inhibitors. We found that Mincle was highly expressed in hepatic innate inflammatory cells and endothelial cells in both mice and humans. Furthermore, sterile Mincle ligands and Mincle signaling intermediates were increased in the murine liver in Con A hepatitis. Most significantly, Mincle deletion or blockade protected against Con A hepatitis, whereas Mincle ligation exacerbated disease. Bone marrow chimeric and adoptive transfer experiments suggested that Mincle signaling in infiltrating myeloid cells dictates disease phenotype. Conversely, signaling via other C-type lectin receptors did not alter disease course. Mechanistically, we found that Mincle blockade decreased the NF-κβ-related signaling intermediates C/EBPβ and HIF-1α, both of which are necessary in macrophage-mediated inflammatory responses. Accordingly, Mincle deletion lowered production of nitrites in Con A hepatitis and inhibition of both C/EBPβ and HIF-1α reduced the severity of liver disease. Our work implicates a novel innate immune driver of Con A hepatitis and, more broadly, suggests a potential role for Mincle in diseases governed by sterile inflammation. Copyright © 2016 by The American Association of Immunologists, Inc.

    9. Variables socionutricionales de hogares mazahuas integrados por preescolares desnutridos con madres con obesidad y sin obesidad

      Directory of Open Access Journals (Sweden)

      Conzuelo González, Viridiana Vanessa

      2009-01-01

      Full Text Available El primer objetivo fue conocer cuántos menores de cinco años con diferentes grados de desnutrición tienen una madre con sobrepeso/obesidad/ en una comunidad indígena que vive en extrema pobreza y bajo condiciones de migración masculina internacional. El segundo fue comparar tres variables socionutricionales (ingreso familiar, educación de la madre y adecuación nutrimental de la dieta diaria entre estos hogares y los hogares con desnutrición infantil y madres sin obesidad. Se realizó un estudio transversal (2006-2007, en la comunidad mazahua de San Francisco Tepeolulco, Municipio de Temascalcingo; que incluyó a 85 hogares integrados por preescolares con desnutrición inscritos al programa Oportunidades. Se determinó el estado nutrición de los preescolares con indicadores antropométricos y se obtuvo el IMC de las madres de estos infantes. Se aplicó una encuesta socionutricional, incluida el recordatorio de 24 horas, y complementado con la observación participante (cualitativa. Se encontró que 83% de las madres mazahuas presentaron sobrepeso u obesidad. El estado de nutrición de los preescolares con madres con obesidad presentó un porcentaje mayor de desnutrición (76%. En la variable género, se encontró que 54% de los niños con madres con obesidad tenía baja talla. Al relacionar el nivel educativo de la madre, esta variable resultó ser estadísticamente significativa (p=0.015, donde el analfabetismo está más relacionado con la desnutrición infantil que tienen madres de bajo y/o peso normal. La elevada prevalencia de hogares conformados con preescolares con desnutrición y madres con obesidad, es un síntoma más de la pobreza en zonas indígenas en México, con bajo índice de desarrollo humano.

    10. Prevalence of symptomatic and silent stress-induced perfusion defects in diabetic patients with suspected coronary artery disease referred for myocardial perfusion scintigraphy

      International Nuclear Information System (INIS)

      Prior, John O.; Calcagni, Maria-Lucia; Bischof Delaloye, Angelika; Monbaron, David; Ruiz, Juan; Koehli, Melanie

      2005-01-01

      Silent myocardial ischaemia - as evaluated by stress-induced perfusion defects on myocardial perfusion scintigraphy (MPS) in patients without a history of chest pain - is frequent in diabetes and is associated with increased rates of cardiovascular events. Its prevalence has been determined in asymptomatic diabetic patients, but remains largely unknown in diabetic patients with suspected coronary artery disease (CAD) in the clinical setting. In this study we therefore sought (a) to determine the prevalence of symptomatic and silent perfusion defects in diabetic patients with suspected CAD and (b) to characterise the eventual predictors of abnormal perfusion. The patient population comprised 133 consecutive diabetic patients with suspected CAD who had been referred for MPS. Studies were performed with exercise (41%) or pharmacological stress testing (1-day protocol, 99m Tc-sestamibi, 201 Tl or both). We used semi-quantitative analysis (20-segment polar maps) to derive the summed stress score (SSS) and the summed difference score (SDS). Abnormal MPS (SSS≥4) was observed in 49 (37%) patients (SSS=4.9±8.4, SDS=2.4±4.7), reversible perfusion defects (SDS≥2) in 40 (30%) patients [SSS=13.3±10.9; SDS=8.0±5.6; 20% moderate to severe (SDS>4), 7% multivessel] and fixed defects in 21 (16%) patients. Results were comparable between patients with and patients without a history of chest pain. Of 75 patients without a history of chest pain, 23 (31%, 95% CI=21-42%) presented reversible defects (SSS=13.9±11.3; SDS=7.4±1.2), indicative of silent ischaemia. Reversible defects were associated with inducible ST segment depression during MPS stress (odds ratio (OR)=3.2, p<0.01). Fixed defects were associated with erectile dysfunction in males (OR=3.7, p=0.02) and lower aspirin use (OR=0.25, p=0.02). Silent stress-induced perfusion defects occurred in 31% of the patients, a rate similar to that in patients with a history of chest pain. MPS could identify these patients with a

    11. Prevalence of symptomatic and silent stress-induced perfusion defects in diabetic patients with suspected coronary artery disease referred for myocardial perfusion scintigraphy

      Energy Technology Data Exchange (ETDEWEB)

      Prior, John O.; Calcagni, Maria-Lucia; Bischof Delaloye, Angelika [Centre Hospitalier Universitaire Vaudois (CHUV University Hospital), Division of Nuclear Medicine, Lausanne (Switzerland); Monbaron, David; Ruiz, Juan [Centre Hospitalier Universitaire Vaudois (CHUV University Hospital), Division of Endocrinology, Diabetology and Metabolism, Lausanne (Switzerland); Koehli, Melanie [Centre Hospitalier Universitaire Vaudois (CHUV University Hospital), Division of Nuclear Medicine, Lausanne (Switzerland); Centre Hospitalier Universitaire Vaudois (CHUV University Hospital), Division of Endocrinology, Diabetology and Metabolism, Lausanne (Switzerland)

      2005-01-01

      Silent myocardial ischaemia - as evaluated by stress-induced perfusion defects on myocardial perfusion scintigraphy (MPS) in patients without a history of chest pain - is frequent in diabetes and is associated with increased rates of cardiovascular events. Its prevalence has been determined in asymptomatic diabetic patients, but remains largely unknown in diabetic patients with suspected coronary artery disease (CAD) in the clinical setting. In this study we therefore sought (a) to determine the prevalence of symptomatic and silent perfusion defects in diabetic patients with suspected CAD and (b) to characterise the eventual predictors of abnormal perfusion. The patient population comprised 133 consecutive diabetic patients with suspected CAD who had been referred for MPS. Studies were performed with exercise (41%) or pharmacological stress testing (1-day protocol, {sup 99m}Tc-sestamibi, {sup 201}Tl or both). We used semi-quantitative analysis (20-segment polar maps) to derive the summed stress score (SSS) and the summed difference score (SDS). Abnormal MPS (SSS{>=}4) was observed in 49 (37%) patients (SSS=4.9{+-}8.4, SDS=2.4{+-}4.7), reversible perfusion defects (SDS{>=}2) in 40 (30%) patients [SSS=13.3{+-}10.9; SDS=8.0{+-}5.6; 20% moderate to severe (SDS>4), 7% multivessel] and fixed defects in 21 (16%) patients. Results were comparable between patients with and patients without a history of chest pain. Of 75 patients without a history of chest pain, 23 (31%, 95% CI=21-42%) presented reversible defects (SSS=13.9{+-}11.3; SDS=7.4{+-}1.2), indicative of silent ischaemia. Reversible defects were associated with inducible ST segment depression during MPS stress (odds ratio (OR)=3.2, p<0.01). Fixed defects were associated with erectile dysfunction in males (OR=3.7, p=0.02) and lower aspirin use (OR=0.25, p=0.02). Silent stress-induced perfusion defects occurred in 31% of the patients, a rate similar to that in patients with a history of chest pain. MPS could identify

    12. Saccharomyces cerevisiae Linker Histone Hho1p Functionally Interacts with Core Histone H4 and Negatively Regulates the Establishment of Transcriptionally Silent Chromatin*

      OpenAIRE

      Yu, Qun; Kuzmiak, Holly; Zou, Yanfei; Olsen, Lars; Defossez, Pierre-Antoine; Bi, Xin

      2009-01-01

      Saccharomyces cerevisiae linker histone Hho1p is not essential for cell viability, and very little is known about its function in vivo. We show that deletion of HHO1 (hho1Δ) suppresses the defect in transcriptional silencing caused by a mutation in the globular domain of histone H4. hho1Δ also suppresses the reduction in HML silencing by the deletion of SIR1 that is involved in the establishment of silent chromatin at HML. We further show that hho1Δ suppresses chan...

    13. Análisis de la operación del sistema nacional interconectado del ecuador utilizando programación en DIgSILENT-DPL

      OpenAIRE

      Canchiña Santana, José Miguel; Hinojosa, Víctor Hugo

      2009-01-01

      La planificación, diseño y el análisis de la operación de sistemas de potencia requieren estudios a fin de evaluar el desempeño del sistema existente, confiabilidad, seguridad y economía. Los estudios identifican y alertan potenciales deficiencias en el sistema factibles de corregir o prevenir. En el presente trabajo se presenta el estudio de las funcionalidades disponibles en el programa DIgSILENT Power Factory, y la implementación y automatización del proceso “Analizar la Operación en Condi...

    14. Epilepsia de la infancia con paroxismos occipitales

      Directory of Open Access Journals (Sweden)

      Albia Pozo Alonso

      1999-09-01

      Full Text Available Se reporta que la epilepsia de la infancia con paroxismos occipitales constituye un síndrome epiléptico muy bien definido; se incluye en el grupo de las epilepsias idiopáticas relacionadas con localización. Los ataques comienzan habitualmente con síntomas visuales, en ocasiones seguidos por ataques hemiclónicos, parciales complejos y tónicoclónicos generalizados. El electroencefalograma interictal muestra complejos de puntaonda de localización occipital y temporal posterior que desaparecen con la apertura de los ojos. Se presenta una paciente de 8 años de edad que reúne los criterios clínicos y electroencefalográficos de la epilepsia de la infancia con paroxismos occipitales y se enfatiza en la evolución supuestamente benigna de dicho síndrome.Is is reported that epilepsy of childhood with occipital paroxysms is an epileptic syndrome that is well defined. It is included in the group of related idiopathic epilepsies with localization. Seizures habitually begin with visual symptoms, which are ocassionally followed by hemiclonic, complex partial, and generalized tonicclonic seizures. The interictal EEG shows spike-wave complexes of occipital and temporal posterior localization that are suppressed by eye opening. A patient aged 8 in whom the clinical and electroencephalographic criteria of epilepsy of childhood with occipital paroxysms are present is studied in this paper. Emphasis is made on the apparently benign evolution of this syndrome.

    15. Association between silent embolic cerebral infarction and continuous increase of P2Y12 reaction units after neurovascular stenting.

      Science.gov (United States)

      Kim, Bum Joon; Kwon, Joo Y; Jung, Jin-Man; Lee, Deok Hee; Kang, Dong-Wha; Kim, Jong S; Kwon, Sun U

      2014-10-01

      Endovascular procedures are one of the important treatment options for steno-occlusive arteries in ischemic stroke patients. However, embolic complications after such procedures are always a concern. The authors investigated the association between serial change of residual platelet reactivity and silent embolic cerebral infarction (SECI) after endovascular treatment. Ischemic stroke patients undergoing stenting of intra- or extracranial arteries were recruited prospectively. Residual platelet reactivity, represented by aspirin reaction units (ARUs) and P2Y12 reaction units (PRUs), was measured serially (6 hours before, immediately after, and 24 hours after the procedure). A loading dosage of aspirin (500 mg) and/or clopidogrel (300 mg) was given 24 hours before the procedure to patients naïve to antiplatelet agents, whereas the usual dosage (aspirin 100 mg and clopidogrel 75 mg) was continued for patients who had previously been taking these agents for more than a week. Diffusion-weighted MRI was performed before and 24 hours after the procedure to detect new SECIs. Clinical characteristics, baseline ARU and PRU values, and the change in ARU and PRU values after stenting were compared between patients with and without SECIs. Among 69 consecutive patients who underwent neurovascular stent insertion, 41 patients (59.4%) had poststenting SECIs. The lesion was located only at the vascular territory of the stented vessel in 21 patients (51.2%), outside the stented vessel territory in 8 patients (19.5%), and both inside and outside in 12 patients (29.3%). The occurrence of SECIs was not associated with the baseline ARU or PRU value, but was associated with PRU increase after stenting (36 ± 73 vs -12 ± 59, p = 0.007), deployment of a longer stent (31.1 ± 16.5 mm vs 21.8 ± 9.9 mm, p = 0.01), and stent insertion in extracranial arteries (78.1% vs 45.2%, p = 0.008). Stent length (OR 1.066, p = 0.01) and PRU change (OR 1.009, p = 0.04) were independently associated with

    16. Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion

      Energy Technology Data Exchange (ETDEWEB)

      Wu, Yuting, E-mail: wuyuting1302@sina.com; Liu, Xuejiao; Zhou, Qun; Huang, Cheng; Meng, Xiaoming; Xu, Fengyun; Li, Jun, E-mail: lj@ahmu.edu.cn

      2015-12-01

      SIRT1 (silent information regulator 1), a conserved NAD +-dependent histone deacetylase, is closely related with various biological processes. Moreover, the important role of SIRT1 in alcoholic liver disease, nonalcoholic fatty liver and HCC had been widely reported. Recently, a novel role of SIRT1 was uncovered in organ fibrosis diseases. Here, we investigated the inhibitory effect of SIRT1 in liver fibrogenesis. SIRT1 protein was dramatically decreased in CCl4-treated mice livers. Stimulation of LX-2 cells with TGF-β1 also resulted in a significant suppression of SIRT1 protein. Nevertheless, TGF-β1-induced LX-2 cell activation was inhibited by SIRT1 plasmid, and this was accompanied by up-regulation of cell apoptosis-related proteins. Overexpression of SIRT1 also attenuated TGF-β1-induced expression of myofibroblast markers α-SMA and COL1a. However, the important characteristic of the recovery of liver fibrosis is not only the apoptosis of activated stellate cells but also the reversal of the myofibroblast-like phenotype to a quiescent-like phenotype. Restoration of SIRT1 protein was observed in the in vivo spontaneously liver fibrosis reversion model and in vitro MDI (isobutylmethylxanthine, dexamethasone, and insulin)-induced reversed stellate cells, and forced expression of SIRT1 also promoted the reversal of activated stellate cells. Furthermore, lncRNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) was increased in liver fibrosis. RNAi-mediated suppression of MALAT1 resulted in a decrease of myofibroblast markers and restoration of SIRT1 protein. These observations suggested that SIRT1 contributed to apoptosis and reversion of activated LX-2 cells and SIRT1 might be regulated by MALAT1 in liver fibrosis. Therefore, SIRT1 could be considered as a valuable therapeutic target for translational studies of liver fibrosis. - Highlights: • This is the first report of SIRT1 expression and function in liver fibrogenesis and reversion.

    17. Making silent bones speak

      DEFF Research Database (Denmark)

      Ivanovaite, Livija; Jensen, Mathias Paul Bjørnevad; Philippsen, Bente

      2017-01-01

      , Obšrūtai and Kamšai were subjected to the AMS dating, tandem mass spectrometry for animal species identification as well as technological and use-wear analysis. The results revealed that all four bone points could be dated to the Boreal period and imply early-to-middle Mesolithic dates. Harpoons from...... of the present research, the paper shortly describes other scientific methods which could be applied to orphaned bone and antler tools including biomolecular and stable isotope analysis. Digital recording methods can be useful for bone artefact recording. This is relevant today, as the demand for good quality...

    18. With Silent Lips

      DEFF Research Database (Denmark)

      Isar, Nicoletta

      2010-01-01

      gennem stilhed af disse paradoksale hellige tekster, som jeg håber at gøre hørbare min komplimenter og de bedste ønsker til min ven, prof. Stefan Smjadovsky Cet article est dédié à une amitié académique durable, inspirante et inspirée, en même temps, par un amour commun pour cette entité vivante...

    19. Tiny, silent killers

      Digital Repository Service at National Institute of Oceanography (India)

      Bhat, S.R.

      contaminated fish and shellfish before they reach market. But it is not so everywhere and therefore toxic blooms are taking a heavy toll. Fish and shellfish losses total tens of millions of dollars every year. While the wild fish can swim away from blooms... for monitoring toxin level in shellfish and accordingly closes or allows its harvest from shellfish beds. Marketable shellfish are generally considered to be safe, but in spite of these precautions, there are known illnesses. One dramatic example is from 1990...

    20. Cooperation or Silent Rivalry?

      DEFF Research Database (Denmark)

      Zank, Wolfgang

      2010-01-01

      a gravitational pull which goes beyond economic problems. Furthermore, the EU has gradually built up a coherent policy on many fields. The EU has become the “reform anchor” and most important cooperation partner for Egypt. The progress towards increasing Egypt’s “Stake in the Internal Market” places cooperation......For decades the US has had a hegemonic position in the Middle East. A key country in this respect has been Egypt. However, in recent decades the EU has made itself increasingly felt in the region. Due to enlargements the EU came geographically much closer, and the Internal Market has generated...... to see the US and EU as rivals. Their roles are rather complementary. The article explores developments in a long-term perspective. Internal and structural developments have had a heavy impact, but at important junctions ideas and strategies for gaining political legitimacy were powerful factors too...