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Sample records for con fiebre dengue

  1. Alteraciones bioquímicas como marcadores predictores de gravedad en pacientes con fiebre por dengue

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    Luis Ángel Villar-Centeno

    2013-08-01

    Full Text Available Introducción. El dengue es la infección transmitida por mosquitos más importante en el mundo. Existe información de que las alteraciones bioquímicas pueden utilizarse como herramientas predictoras de gravedad del dengue. Objetivo. Evaluar las alteraciones bioquímicas como posibles marcadores predictores de gravedad del dengue. Materiales y métodos. Se llevó a cabo un estudio de casos y controles anidado en una cohorte. Se seleccionaron al azar 125 casos con dengue grave y 120 controles con dengue no grave para evaluar los niveles séricos de lactato-deshidrogenasa (LDH, creatina cinasa (CK, proteína C reactiva(PCR y albúmina, en sueros obtenidos en las primeras horas de la enfermedad. Para evaluar el valor diagnóstico de cada biomarcador, se establecieron puntos de corte con una sensibilidad del 90 % enla detección de casos graves. Resultados. Se observó una asociación entre los niveles de PCR por debajo de 9,8 mg/l (OR=0,04;IC95%=0,02-0,08; p=0,000, de LDH inferiores a 400 U/L (OR=0,49; IC95%=0,24-1,02; p=0,053 y de albúmina menor de 4 mg/dl (OR=3,46; IC95%=1,96-6,12; p=0,000, con la gravedad del dengue. En contraste, los niveles de la CK no mostraron asociación con la gravedad de la enfermedad. Conclusiones. Los hallazgos de nuestro estudio sugieren una asociación de los niveles de PCR, LDH y albúmina con la gravedad del dengue. Estas pruebas bioquímicas podrían ser utilizadas como herramientas predictoras del curso clínico de la infección.   doi: http://dx.doi.org/10.7705/biomedica.v33i0.732

  2. Comunicación, movilización y participación: lecciones aprendidas en la prevención y control de la fiebre dengue (fd

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    Mario Mosquera

    2006-01-01

    Full Text Available Este artículo presenta los resultados de un estudio de intervención- investigación ejecutado durante 2003-2005 en el Atlántico (Colombia, con el propósito de mejorar la efectividad y sostenibilidad de los programas de control de Fiebre Dengue (FD, a través de una estrategia de comunicación participativa basada en los recursos comunicacionales locales y en los conocimientos, prácticas y percepciones de la comunidad; se exponen las lecciones aprendidas en torno a dimensiones críticas de las intervenciones en comunicación y salud organizadas en dos áreas: dimensiones político-técnicas y dimensiones teóricas y de investigación. El proyecto se desarrolló partir de la metodología combi, abordaje de comunicación y movilización social que incluye un proceso estratégico para identificar, promover y facilitar comportamientos que puedan repercutir en forma positiva y significativa y que sean factibles de lograr. Como variante al combi, se introdujeron componentes de participación social en la implementacion del proceso. Las lecciones aprendidas incluyen re- flexiones sobre el rol de los organismos rectores, la integralidad de las estrategias, el impacto de las intervenciones de comunicación en los indicadores entomológicos, la expansión de referentes teóricos en dengue y la posibilidad de abordar otras problemáticas de salud a partir de procesos participativos centrados en dengue.

  3. Fiebre petequial experimental de las montañas rocosas: resultado del tratamiento con algunas drogas (1

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    Edward A. Steinhaus

    1944-02-01

    Full Text Available En 1939, Topping informó que el Prontosil y la sulfadiazina aparentemente no tenían valor en el tratamiento de la fiebre petequial de las Montañas Rocosas, en los curíes. Estudios recientes han conducido a los autores a la misma observación con respecto al Sulfatiazol, Sulfatiazol sódico, Sulfaguanidina, Sulfadiazina, Atebrina y Tirotricina (2. Se usó una cepa de alta y fatal virulencia, de Fiebre Petequial de las Montañas Rocosas del oeste de Montana. La dosificación de cada una de las drogas varió de acuerdo con el grado de toxicidad. En general, por lo menos se usaron 3 dosificaciones y de estas se administraban una vez, 2 ó 3 veces al día. Todos los datos se resumen en el Cuadro N° 1.

  4. Síndrome hemofagocítico asociado con dengue hemorrágico

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    Ernesto Rueda

    2002-06-01

    Full Text Available El síndrome hemofagocítico se caracteriza por proliferación histiocítica con fagocitosis de células hemáticas que ocasionan citopenia. Ha sido relacionado antes con diversas infecciones, principalmente por virus. Informamos de tres pacientes con síndrome hemofagocítico secundario a dengue hemorrágico, confirmado por exámenes específicos de laboratorio, quienes fueron internados en el Hospital Universitario Ramón González Valencia de Bucaramanga, Colombia, durante los últimos dos años. Los tres pacientes fueron escolares que presentaron dengue hemorrágico y manifestaron dolor abdominal intenso, fiebre prolongada, hipotensión y hepatomegalia dolorosa; los exámenes paraclínicos mostraron plaquetopenia, anemia y leucopenia; en la ecografía abdominal se observó colecistitis acalculosa y en todos los aspirados de medula ósea se encontraron histiocitos fagocitando células hemáticas de la serie eritroide, mieloide o plaquetaria. Se definió y clasificó el síndrome hemofagocítico, según la Sociedad Internacional de Histiocitosis, en tres grandes clases, recalcando que los casos informados corresponden a histiocitosis clase II y, más específicamente, al síndrome hemofagocítico secundario. Se mencionan las diversas asociaciones de este síndrome con infecciones, principalmente virales, y otras enfermedades no infecciosas; se hace diferenciacion entre síndrome hemofagocítico familiar o primario y el secundario. Finalmente, se enfatiza que los tres pacientes con este síndrome asociado con dengue hemorrágico tuvieron una evolución atípica durante el curso de su enfermedad; la fiebre prolongada y el dolor abdominal persistente fueron los síntomas más importantes. Los autores recomiendan realizar un aspirado de médula ósea como parte de los estudios para el diagnóstico diferencial de casos atípicos de dengue, especialmente con fiebre prolongada, buscando la posibilidad de un síndrome hemofagocítico secundario.

  5. Fiebre tifoidea

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    Reyes S., Álvaro A.; Sierra, Fernando; Racines A., Dorman; Saravia, Jaime

    2012-01-01

    Se revisa la experiencia del Hospital San Juan de Dios de Bogotá Universidad Nacional en fiebre tifoidea entre 1979 y 1986. Se presentaron 24 casos; 17 hombres y 7 mujeres con edad promedio de 22.2 años (rango entre 15 y 40 años), la mayoría proveniente de aéreas urbanas. La duración promedio de la sintomatología antes de consultar fue de 18.7 días y la estancia hospitalaria promedio fue de 19.5 días.

  6. Fiebre tifoidea

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    Álvaro A. Reyes S.

    1986-10-01

    Full Text Available Se revisa la experiencia del Hospital San Juan de Dios de Bogotá Universidad Nacional en fiebre tifoidea entre 1979 y 1986. Se presentaron 24 casos; 17 hombres y 7 mujeres con edad promedio de 22.2 años (rango entre 15 y 40 años, la mayoría proveniente de aéreas urbanas. La duración promedio de la sintomatología antes de consultar fue de 18.7 días y la estancia hospitalaria promedio fue de 19.5 días.

  7. Aceites esenciales de plantas colombianas inactivan el virus del dengue y el virus de la fiebre amarilla Essential oils from Colombian plants inactive dengue virus and yellow fever virus

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    Rocío Meneses

    2009-12-01

    Full Text Available Introducción: Un antiviral contra el virus del dengue (VDEN y el virus de la fiebre amarilla (VFA para tratamiento de los enfermos, no está disponible en el mercado a pesar de numerosas investigaciones con compuestos sintéticos. Objetivo: Evaluar el efecto inhibitorio in vitro sobre el VDEN y el VFA del aceite esencial obtenido de plantas cultivadas en Colombia. Materiales y métodos: Los virus se incubaron con el aceite esencial (100 μg/mL 2 h a 37°C antes de la adsorción a la célula y el efecto inhibitorio fue determinado por el método de reducción de placa. Resultados: El aceite esencial obtenido de 10 y 8 plantas redujo desde 74 hasta 100% placas del VDEN y del VFA, respectivamente. Los aceites de Lippia citriodora (verbena y Pimenta racemosa (laurel fueron más activos contra ambos virus reduciendo 100% las placas. La magnitud del efecto inhibitorio se relacionó con el método de extracción del aceite y la parte de la planta seleccionada. Conclusiones: El aceite esencial de plantas colombianas puede inhibir la replicación in vitro del VDEN y VFA. Se requieren más estudios para determinar la concentración mínima inhibitoria y el índice de selectividad para considerar estas plantas como fuente de compuestos antivirales. Salud UIS 2009; 41: 236-243Introduction: Products obtained from plants can inhibit in vitro viruses that cause human diseases. An antiviral drug against dengue virus (DENV and yellow fever virus (YFV does not exist despite extensive research exploring synthetic compounds. Objective: To evaluate the inhibitory effect on DENV and YFV of essential oils obtained from Colombian plants. Materials and methods: Viruses were incubated with essential oil (100 μg/mL 2 h at 37°C before cell adsorption and the inhibitory effect was determined by plaque reduction assay. Results: The essential oil obtained from 10 and 8 plants reduced from 74 to 100% DENV and YFV plaques, respectively. Essential oils from Lippia citriodora

  8. Prevalencia de Leptospirosis y factores de riesgo en personas con antecedentes de fiebre en la Provincia de Manu, Madre de Dios, Perú

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    Manuel Céspedes Z

    2003-10-01

    Full Text Available Objetivos: Determinar la prevalencia de leptospirosis y los factores de riesgo en personas con antecedentes de fiebre en localidades dedicadas a actividades mineras (lavaderos de oro y la prevalencia de infección en perros en la provincia de Manu, departamento de Madre de Dios, Perú. Material y métodos: Estudio transversal analítico. Se tomaron 71 muestras de sangre de personas con antecedentes de fiebre, provenientes de cinco localidades dedicados a la actividad minera, en ellos se evaluaron la presencia de anticuerpos IgM e IgG contra leptospiras en suero por el método de ELISA y la prueba de microaglutinación (MAT. Los factores asociados a la infección por leptospiras fue evaluada a partir de una encuesta. Además se tomaron muestras de sangre a 27 perros que evaluados por el método de MAT Resultados: Se enrolaron 71 personas de las cuales 47 (66,2% fueron mujeres y 24 (33,8 % varones, 26 (36,6% pobladores presentaron anticuerpos contra leptospiras. Los factores asociados a la infección por leptospiras en los pobladores fueron: consumo de agua de río en el hogar (OR=9,09 p=0,017, consumo de agua de río en el campo (OR=7,13 p=0,042, nadar en el río (OR=4,60 p=0,13, habitar en una vivienda con techo de plástico y paja (OR=4,04 p=0,013. En canes, 18 (66,6% tuvieron serología positiva a leptospiras. Conclusiones: Existe una alta prevalencia de leptospirosis en personas con antecedentes de fiebre y condiciones favorables para la presencia de leptospiras en las localidades estudiadas. En estas zonas se recomienda realizar actividades educativas preventivas, tomando en cuenta los factores de riesgo identificados.

  9. Diagnóstico inmunohistoquímico del dengue en cortes de parafina

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    Ladys Sarmiento

    1995-03-01

    Full Text Available La demostración de antígenos de losvirus del dengue en tejidos de pacientes fallecidos por dengue hemorrágico y particularmente en aquellos casos en los que no se dispone de otras pruebas para confirmar la etiologíaviral, es una necesidad frecuente en nuestro medio. Por esta razón, estandarizamos una técnica inmunohistoquírnica para detectar antígenos de dengue en tejidos incluidos en parafina. Utilizamos anticuerpos antiflavivirus comúnmente usados para el diagnóstico serológico. Los antígenos empleados para estandarizar esta técnica incluyeron: 1 cerebros de ratón inoculados con los diferentes serotipos del dengue y con virus de la fiebre amarilla; 2 cortes de hígados de pacientes fallecidos con diagnóstico clínico de dengue hemorrágico, fiebre amarilla o hepatitis delta; y, 3 monocapas de c6lulas C6136 inoculadas también con los diferentes serotipos del dengue. Estos antígenos se enfrentaron a los anticuerpos antiflavivirus (fiebre amarilla o dengue preparados como líquidos ascíticos inmunes (MI de ratón, siguiendo procedimientos ya establecidos. Utilizamos LA1 preparados en el INS y LA1 suministrados por la OPS. Ladilución ideal de trabajocon la cual pudimos 0bse~alra presencia del antígeno, tanto en los tejidos como en las células, se obtuvo titulando los distintos LA1 frente a cortes de tejido desparafinado o frente a las c6lulas fijadas en etanol sobre la lámina de vidrio. Con los LA1 preparados en el INS, O ~ S ~ N ~ re~aOccSión cruzada entre todos los flavivirus, resultado que no se 0bseNó en los cortes de hígado con diagnóstico de hepatitis delta. Los resultados obtenidos con los MI de la OPS permitieron visualizar los antígenos virales más claramente y a diluciones más altas, sin la reacción cruzada entre el dengue y la fiebre amarilla. Sin embargo, la visualización de los mismos con los LA1 del INS es satisfactoria y con disponibilidad permanente. La reacción cruzada entre los virus del dengue y

  10. Caracterización de los pacientes con dengue Characterization of the patients suffering from dengue

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    Ivette González Fajardo

    2011-09-01

    Full Text Available Se revisaron las 31 historias clínicas de los pacientes ingresados en el Centro Diagnóstico Integral "Raúl Maza Mérida" del estado Delta Amacuro, municipio Tucupita con el diagnóstico positivo de dengue, confirmado de forma clínica e inmunológica (IgM positiva. Se analizaron las variables: sexo, edad, procedencia, incidencia por meses, síntomas, complicaciones, resultados analíticos e imagenológicos y evolución. El método estadístico utilizado fue el test Ji cuadrado de Pearson, considerando valores de p Thirty one clinical charts of the patients admitted at “Raul Maza Merida” Comprehensive Center of Diagnostic in Delta Amacuro State, Tucupita municipality were analyzed, these patients suffered from dengue which was verified immunological (IgM and clinically. Sex, age, origin, incidence per months, symptoms, complications, analytical and imaging results together with the follow up of evolution were the variables considered. The statistical method used was Pearson’s chi square test, taking into consideration the values of p< 0, 05 statistically significant along with other percentage values. Male sex (58,1%, 15 and 29 years old (48, 4% prevailed, and July (35,5% was the month showing the highest incidence, no cases were reported in November or December. General malaise and fever were present in 100% of the patient’s most frequent symptoms in the onset period, and headache the most lasting sign during the disease progress, observing a reduction of admissions on the second day of the onset of symptoms. The 62.5% of the cases of hemorrhagic dengue presented complications, only 4.3% of fevers due to dengue resulted in statistical significance. Megacaryopoietic series was the last to be recovered. Echo-sonographic alterations were detected in 25.8% of the cases and only 9.6% presented radiological alterations. The presence of ascitic fluids resulted the most frequent finding, 100% of the patients underwent parenteral hydration

  11. Anemia y fiebre en el postrasplante renal: su relación con el parvovirus humano B19

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    Yanet Parodis López

    2017-03-01

    Presentamos el caso clínico de un varón de 65 años con trasplante renal de donante cadáver en septiembre de 2014. A los 38 días del trasplante comienza con anemia progresiva y resistente a los agentes estimulantes de la eritropoyesis. A los 64 días se produce hipertermia, con deterioro progresivo de su estado general. La serología vírica resultó negativa, al igual que la PCR inicial en sangre del parvovirus humano B19. A los 4 meses y 19 días se realiza una biopsia de médula ósea en la que se observan eritroblastos gigantes con inclusiones víricas nucleares compatibles con parvovirus, por lo que se realiza una PCR en dicho tejido que confirma el diagnóstico. Una segunda PCR en sangre resultó positiva. Tras el tratamiento con inmunoglobulinas intravenosas (IGIV y la suspensión temporal del micofenolato de mofetilo, se produce una remisión completa de la enfermedad, aunque persistía positiva la PCR para el parvovirus B19 en sangre, lo que hace necesario vigilar probables recidivas.

  12. Farmacocinética y farmacodinamia de antimicrobianos: a propósito de pacientes con neutropenia y fiebre

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    Garzón, Javier R; Cuervo M, Sonia; Gómez R, Julio; Cortés, Jorge A

    2011-01-01

    La neutropenia febril es una complicación grave de la terapia antineoplásica que se presenta más frecuentemente en pacientes con neoplasias hematológicas, asociada a tasas elevadas de mortalidad. Uno de los factores descritos como causa de fracasos terapéuticos de la terapia antimicrobiana es la inadecuada concentración tisular de los antimicrobianos que a su vez se correlaciona con bajas concentraciones en el líquido intersticial en el caso de los fármacos hidrofílicos. En pacientes críticam...

  13. Dengue en Colombia

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    Jorge Boshell

    1986-12-01

    Full Text Available El Gobierno Colombiano estableció una campaña que erradicó el Aedes aegypti de su territorio en atención a las recomendaciones que hizo la Oficina Sanitaria Panamericana en 1947. Esta campaña consiguió desaparecer el dengue endémico durante aproximadamente 20 años, apareciendo de nuevo en forma explosiva con la epidemia de dengue 2 en la Costa Atlántica (1971-1972, seguida de dos epidemias bien documentadas de dengue 3 (1975-1977 y dengue 1 en 1978. Se hace un resumen de las actividades que desarrolla el Laboratorio de Virología del Instituto Nacional de Salud para apoyar el diagnóstico de esta enfermedad en el país incluyendo el primer aislamiento de dengue 4 en 1982, la actividad de los virus dengue 1, 2 y 4 detectada hasta la fecha, los hallazgos clínicos y virológicos en un caso fatal de enfermedad hemorrágica asociada a infección por virus del dengue y un breve recuento de la epidemia de Tumaco en la Costa Pacífica en la cual se comprobó actividad simultánea de dengue 1 y 2. Finalmente se informa sobre el estado de infestación que tiene el país actualmente con el Aedes aegypti y sobre la actividad del virus de fiebre amarilla en focos selváticos vecinos a ciudades altamente infestadas, detectada en el mes de enero de 1987 en Colombia.

  14. Notas clínicas: un caso de fiebre tifoidea con supuración hepática

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    César A. Pantoja

    1933-02-01

    habitualmente en Bogotá, entró al servicio de Clínica de Enfermedades tropicales del protesor Roberto N. Franco el 15 de agosto de 1932. La noche de su llegada al servicio sufrió una orisis de delirio y agitación, haciéndose necesario obligarla, por la fuerza, a permanecer en la cama para evitar su insistencia de arrojarse por la ventana; este estado delirante alternó con fases de depresión, todo lo cual contribuyó a que el interrogatorio no se hiciera de una manera satisfactoria; de aquí la falta de antecedentes hereditarios y personales. Sólo pudo sacarse a luz que la enfermedad actual le comenzó hacía diez días por una elevación gradual de la temperatura, con fuerte alteración del estado general. Al llegar al hospital tenía 39,5 grados de temperatura.

  15. Fiebre "Q" en Uruguay

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    R. E. Somma Moreira

    1987-06-01

    Full Text Available Los autores hacen una revisión de la problemática referida a la fiebre Q, tanto desde el punto de vista clínico como epidemiológico. El primer caso nacional se comunicó en el año 1956, en un adulto, obrero de frigorífico. En 1966 se comunica el primer caso en un niño. A partir de esa fecha se realizan varias encuestas serológicas en humanos y en animales. En seres humanos los hallazgos varían entre 4.2% y 5.5% según el año estudiado. En animales se hallaron valores que oscilaron entre 0.9% (animal para abasto y 30% (animal tipo industria para bovinos. En ovinos, en el único estudio se halló un 10.3% de positivos. En equinos los valores de positividad variaron de 5.5% a 21.7%. En suinos se refiere un porcentaje de positividad del 21.2% en la primera encuesta, sendo en la más reciente del 0.0%. En aves y cobayos no se evidenciaron sueros positivos. Entre 1975 y 1985 los autores estudiaron 14 brotes en seres humanos en esta-blecimentos de procesamiento de carne, con un total de 1358 casos estudiados, habiéndose confirmado el 60% de ellos. Pasan revista a la sintomatologia común, así como el tipo de tarea de los pacientes. Para los estudios serológicos, como los diagnósticos de los casos clínicos, los autores utilizaron la fijación del complemento, la aglutinación capilar y la microa-glutinación en lámina.

  16. Evaluación serológica de una proteína recombinante a partir de una cepa aislada del virus de la fiebre amarilla en el Perú: un estudio piloto

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    Carlos Yábar V

    2003-10-01

    Full Text Available Objetivo: Evaluar serológicamente una proteína recombinante de 66 kDa (Er66 de una cepa del virus de la fiebre amarilla aislada en el Perú usando anticuerpos inmunoreactivos. Material y métodos: La proteína Er66 fue expresada in vitro en la bacteria Escherichia coli y enfrentada a títulos de 1/100, 1/50 y 1/25 de anticuerpos monoclonales, y a sueros con anticuerpos IgM e IgG inmunoreactivos contra el virus de la fiebre amarilla mediante ensayos de Western blot (WB. Asimismo, se evaluaron proteínas totales de las cepas de referencia del virus dengue (DEN y fiebre amarilla como controles de antigenicidad. Resultados: La proteína recombinante Er66 presentó antigenicidad contra títulos de 1/50 y 1/25 de anticuerpo monoclonal (MAB8701; sin embargo, no se observó inmunoreactividad en sueros positivos para fiebre amarilla y dengue. Los ensayos con extractos crudos de la cepa de fiebre amarilla Asibi 17D (PTFA revelaron que la antigenicidad de las proteínas virales comprendidas entre 60 y 80 kDa fue afectada negativamente a temperaturas desnaturalizantes de 100°C. En cambio, tratamientos con ß-mercaptoetanol sin calor generó un aumento de la antigenicidad de dichas proteínas. Siguiendo este mismo principio, la proteína Er66 fue sometida a tratamientos desnaturalizantes con ß-mercaptoetanol sin incluir calor y fue enfrentada nuevamente a los sueros reactivos. El resultado final reveló que la proteína Er66 generó inmunoreactividad frente a sueros con altos títulos de anticuerpos IgM e IgG para fiebre amarilla mientras que en otras muestras se observó una débil señal. Conclusiones: Los datos obtenidos en este trabajo demuestran que la Er66 pudo ser reconocida por anticuerpos IgM e IgG específicos para fiebre amarilla presentes en sueros de pacientes infectados. Los datos presentados en este artículo sugieren el uso de proteínas recombinantes como posibles candidatas de valor diagnóstico para la FA.

  17. Estudios entomológicos del Aedes aegypti relacionados con la epidemiología del dengue

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    Clara B. Ocampo

    2004-03-01

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    La fiebre de dengue (FD y el dengue hemorrágico (DH son enfermedades producidas por la transmisión del virus de dengue (serotipos 1 – 4 a través de los mosquitos Aedes aegypti y A. albopictus. Ambos vectores están altamente adaptados a vivir en ambientes urbanos especialmente en las áreas tropicales.

    El virus de dengue es el arbovirus más importante que afecta a los humanos (1-3, pero hasta el momento no existe una vacuna y su prevención se basa principalmente en el control de sus vectores. En Colombia, el principal vector es A. aegypti, el cual se encuentra en la mayoría del territorio Nacional por debajo de los 1.800 metros, sin embargo, ya se observa la presencia de A. albopictus en unas localidades de frontera amenazando con su desplazamiento en todas las áreas del país (4, 5.

    Adicionalmente, existe la presencia de todos los serotipos de dengue, lo que nos ubica como un territorio hiperendémico de dengue. Los programas de control se basan en el control de criaderos, aplicación de insecticidas y educación ambiental, pero esto no ha sido suficiente para controlar el incremento de la enfermedad en el país.

    Son múltiples los factores asociados con la capacidad de un vector de transmitir un patógeno. Entre ellos se encuentran su densidad, el comportamiento y las características intrínsecas, que permiten el desarrollo y transmisión del patógeno, lo que se conoce como competencia vectorial.

    La capacidad adaptativa del A. aegypti y del A. albopictus para reproducirse en cualquier recipiente con agua en los ambientes urbanos y su comportamiento de

  18. Dengue

    Science.gov (United States)

    Dengue is an infection caused by a virus. You can get it if an infected mosquito bites you. Dengue does not spread from person to person. It ... the world. Outbreaks occur in the rainy season. Dengue is rare in the United States. Symptoms include ...

  19. Evidencia serológica de la presencia de Rickettsias del grupo de la fiebre manchada en la Amazonía del Perú

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    Moisés Sihuincha M

    2006-10-01

    Full Text Available Con el objetivo de demostrar la existencia de transmisión de Rickettsias del grupo de la fiebre manchada en la Amazonía peruana, se tomaron muestras de sangre a pacientes febriles agudos en establecimientos de salud de la ciudad de Iquitos, la ciudad más poblada de la Amazonía del Perú. Las muestras fueron procesadas mediante inmunofluorescencia indirecta para medir anticuerpos totales e IgG específica para el grupo de fiebre de las manchadas. Entre enero y julio de 2006, se obtuvieron muestras de 250 pacientes. El 37% de las muestras tuvieron títulos positivos de IgG, demostrando así haber tenido contacto con el agente, de ellas, nueve fueron clasificadas como casos agudos, en los que se descartó otras infecciones endémicas como dengue, malaria y leptospirosis. Los casos presentaron una enfermedad febril acompañada de síntomas como tos, sarpullido y hemoptisis. Cuatro casos fueron hospitalizados, dos fueron graves y uno de ellos falleció. En conclusión, existe evidencia serológica de la circulación de Rickettsias del grupo de las fiebre manchada en la Amazonía peruana, por su frecuencia y potencial gravedad debería ser tomada en cuenta como diagnóstico diferencial del síndrome febril agudo en esta región.

  20. Vacunación contra la fiebre amarilla en Colombia

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    Hugh H. Smith

    1940-07-01

    Full Text Available El primer método efectivo de vacunación contra la fiebre amarilla que pudo ser adaptado para uso humano se basó en el trabajo de Theiler, quien en 1930 anuncio una marcada variación en el virus de la fiebre amarilla producida por pases consecutivos en cerebro de ratón blanco. Se hallo que este virus de cerebro de ratón, aunque poseía un neurotropismo aumentado, había perdido mucho viscerotropismo, Io cual sugirió su empleo como agente antigénico en la vacunación contra la fiebre amarilla. En 1931, Sawyer, Kitchen y Lloyd (2 anunciaron un método de vacunación en el que se usaba virus de cerebro de ratón simultáneamente como dosis adecuada de suero humano inmune para contrarrestar la actividad patógena de aquel. Este método de vacunación cumplió con su finalidad inmediata que era terminar con la gran serie de infección y muerte entre los investigadores de la fiebre amarilla, pero no era practico para uso en grande escala en el control de la fiebre amarilla, a causa de la dificultad de obtener y administrar la cantidad de suero inmune requerida.

  1. A young woman with first-trimester metrorrhagia, fever and skin lesions Mujer joven con metrorragia del primer trimestre, fiebre y lesiones cutáneas

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    A. Lalueza Blanco

    2006-03-01

    Full Text Available Inflammatory bowel disease commonly affects women with child-bearing potential, and clinical activity extent is most relevant at the time of conception. Below, we report on the case of a 19-year-old woman who was admitted for first-trimester metrorrhagia and fever, with various extraintestinal manifestations, mainly including erythema nodosum and episcleritis during the course of disease. The differential diagnosis of these manifestations led to the diagnosis of Crohn's disease, which involved the whole colon.La enfermedad inflamatoria intestinal afecta frecuentemente a mujeres en edad fértil, siendo fundamental el grado de actividad clínica en el momento de la concepción. A continuación se presenta el caso de una mujer de 19 años que ingresa por metrorragia del primer trimestre y fiebre; destacando durante su evolución la aparición de diferentes manifestaciones extraintestinales, fundamentalmente eritema nodoso y epiescleritis. A través del diagnóstico diferencial de estas manifestaciones se llegó al diagnóstico de una enfermedad de Crohn que afectaba a todo el colon.

  2. Condiciones locales de vulnerabilidad asociadas con dengue en dos comunidades de Morelos Local conditions of vulnerability associated with dengue in two communities of Morelos

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    Silvia Chuc

    2013-04-01

    Full Text Available OBJETIVO: Evaluar las condiciones de vulnerabilidad asociadas con la ocurrencia de dengue en dos localidades de Morelos en los años 2006 a 2009. MATERIAL Y MÉTODOS: se aplicó una encuesta sobre conocimientos, percepción de riesgo, prácticas de prevención y uso del agua en dos localidades de Morelos. Mediante un análisis de componentes principales, se construyó un índice de vulnerabilidad local al dengue (IVL. La asociación del IVL con la enfermedad en la vivienda se evaluó mediante una prueba de ji cuadrada. RESULTADOS: El IVL incluyó cinco componentes explicando el 63% de la varianza y fue clasificado en tres categorías: baja, media y alta. Se observó una asociación significativa entre el aumento de la vulnerabilidad y la prevalencia del reporte de casos de dengue en las localidades. CONCLUSIÓN: El estudio de la vulnerabilidad al dengue permite identificar necesidades locales específicas en materia de promoción de la salud.OBJECTIVE: To evaluate the vulnerability associated with the occurrence of dengue in two villages of Morelos, Mexico from 2006 to 2009. MATERIALS AND METHODS. A survey on knowledge, risk perception, prevention practices and water use was applied in two villages of Morelos. Using a principal component analysis, an index of local vulnerability to dengue (IVL was constructed. The association of IVL with the disease at home was assessed using a Chi-square test. RESULTS: The IVL included five components explaining 63% of the variance and was classified in three categories: low, medium and high. There was a significant association between increased vulnerability and prevalence of reported cases of dengue in Temixco and Tlaquiltenango. CONCLUSION: The study of vulnerability to dengue allows us to identify local needs in the field of health promotion.

  3. Dengue

    Science.gov (United States)

    ... emerged as a worldwide problem only since the 1950s. Although dengue rarely occurs in the continental United ... OIG 1600 Clifton Road Atlanta , GA 30329-4027 USA 800-CDC-INFO (800-232-4636) , TTY: 888- ...

  4. Community beliefs and practices about dengue in Puerto Rico Creencias y prácticas comunitarias relacionadas con el dengue en Puerto Rico

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    Carmen L. Pérez-Guerra

    2009-03-01

    en las tareas de prevención del dengue sigue siendo un reto en Puerto Rico. A partir de entrevistas realizadas en 2001 se analizaron las diferencias en las actitudes hacia el dengue y su prevención según el sexo de los encuestados y sus antecedentes de haber sufrido esta enfermedad. Estos resultados pueden servir para desarrollar mensajes dirigidos a promover prácticas de control de Aedes aegypti. MÉTODOS: Entre septiembre y octubre de 2003 sesionaron 11 grupos focales en San Juan, Puerto Rico. Participaron 59 personas (35 mujeres y 24 hombres de 18 años o más, identificados a través del sistema de vigilancia de dengue de Puerto Rico. El análisis se basó en la teoría fundamentada o inductiva. RESULTADOS: Las mujeres consideraban importante el dengue por su impacto económico, emocional y sanitario y más mujeres que hombres estaban preocupadas por la insuficiente recolección de basura y disposición de aguas residuales. Los participantes con diagnóstico previo de dengue estaban más preocupados por los riesgos de la enfermedad, conocían más sobre el dengue y su prevención y con mayor frecuencia aconsejaron el uso de repelentes que sus pares sin diagnóstico previo de dengue. Entre las barreras para la prevención sostenida del dengue estaban: conceptos erróneos por materiales educativos obsoletos, la " invisibilidad" del dengue en comparación con las enfermedades crónicas y la falta de aceptación de responsabilidad por la prevención del dengue. CONCLUSIONES: Las estrategias sugeridas para motivar la acción de los residentes comprenden: trabajar con las agencias gubernamentales para resolver los problemas estructurales que incrementan las poblaciones de mosquitos, mejorar el acceso a la información sobre la recolección de basura y la disposición de las aguas residuales mediante líneas telefónicas de asistencia directa, aumentar la propaganda y la información sobre el dengue mediante campañas por los medios masivos de información y educar

  5. La fiebre en los niños

    OpenAIRE

    Madriñan T., Jorge; Fundación Valle de Lili

    2007-01-01

    ¿Por qué se produce la fiebre?/¿Para qué sirve la fiebre?/¿Qué es la fiebre-fobia?/Factores que contribuyen a la "fiebre-fobia"/¿Cómo se maneja la fiebre?/¿La fiebre produce convulsiones febriles?/¿Cuándo llamar al médico?

  6. Bartoneliasis: fiebre verrucosa del guaitara en colombia

    OpenAIRE

    Patiño Camargo, Luis

    2011-01-01

    En Colombia, al descubrirla, diósele (1) a esta dolencia los siguientes nombres: Bartonellosis, Fiebre verrucosa del Guaitara y Verruga, análoga a la enfermedad de Carrión, Fiebre de Oroya y Verruga Peruana.

  7. Rabdomiolisis y miocarditis asociados con infección por el virus dengue

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    Oscar G. Pamo Reyna

    2008-07-01

    Full Text Available Se presenta el caso de una paciente que reside en el distrito de Mazamari, provincia de Satipo (selva central del Perú, con un cuadro clínico de dengue, confirmado por serología, donde las mialgias fueron una de las manifestaciones importantes y que desarrolló rabdomiolisis, CPK 6931 μ/L (VN 0-190 μ/L y miocarditis a juzgar por las elevaciones de CPK-MB y troponina I. El tratamiento sintomαtico y una adecuada hidrataciσn permitieron la recuperación de la paciente sin complicaciones mayores.

  8. Tromboflebitis extensa como causa de fiebre insidiosa puerperal

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    Charco Roca, Luisa María; Bonmatí García, Lorena; Rubio Postigo, Gem

    2015-01-01

    Los eventos tromboembólicos son factores contribuyentes esenciales de morbilidad y mortalidad materna. La enfermedad tromboembólica complicada en el periodo puerperal a menudo se presenta con fiebre de causa desconocida y un dolor abdominal que puede confundirse con síntomas del postparto (1). El diagnostico de estos procesos deben hacerse por tomografía axial computerizada (TAC) (1,2). La terapia antiinflamatoria, antibiótica y anticoagulante oportuna y eficaz puede mejorar significativament...

  9. El citoesqueleto en la infección con virus dengue

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    Francisco Javier Díaz Castrillón

    2004-03-01

    Full Text Available

    El dengue constituye la enfermedad viral transmitida por artrópodos más frecuente en Colombia y otros países en vías de desarrollo del trópico. La incidencia anual en Colombia es de aproximadamente 50.000 casos. Aunque el dengue tiene baja mortalidad, es una enfermedad con gran impacto económico en países en vía de desarrollo; inclusive podría postularse como un indicador de subdesarrollo.

    Durante los últimos años, debido principalmente al aumento en la temperatura global, el crecimiento de la población humana con planes de urbanización precarios y la alteración de los ecosistemas naturales, ha sido notorio un incremento en la frecuencia del dengue (DF, y la aparición de cuadros clínicos severos, como dengue hemorrágico (DHF y síndrome de choque por dengue (DSS. Las diferencias en la severidad han sido asociadas a infecciones con los diferentes serotipos del virus, potenciación dependiente de anticuerpos (ADE producto de infecciones secundarias con distintos serotipos y al nivel molecular, por la variabilidad genotípica de los virus.

    Con el surgimiento de una nueva rama “Biología Celular de la Infección Viral”, se abren nuevas posibilidades para el estudio de la patogénesis viral, en el contexto de la interacción virus-célula. Dentro de la familia Flaviviridae, algunas publicaciones reportan alteraciones del citoesqueleto en células infectadas con diversos virus, siendo estos resultados claves para el entendimiento de la utilización de la célula por los virus y la comprensión de la relación entre las proteínas celulares y las virales.

    La diferenciación entre DHF y DF ha sido difícil, por lo que nuevos

  10. Desarrollo de un método de transcripción inversa seguida de reacción en cadena de la polimerasa para la detección del virus de la fiebre amarilla

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    María C. Méndez

    2013-08-01

    Full Text Available Introducción. La fiebre amarilla se considera una enfermedad reemergente y endémica en regiones tropicales de África y Suramérica. Actualmente, no existen estuches estandarizados o comerciales disponibles para la detección del virus de la fiebre amarilla y, por lo tanto, el diagnóstico debe hacerse mediante técnicas de rutina que consumen mucho tiempo y algunas veces no garantizan la detección del virus o de sus proteínas. Además, la cocirculación con otros flavivirus, incluyendo el del dengue, hacen el diagnóstico más complicado. Objetivo. Desarrollar un ensayo específico de amplificación basado en transcripción inversa seguida de reacción en cadena de la polimerasa, con el fin de mejorar la detección y el diagnóstico de la fiebre amarilla, tanto a partir de suero como de tejido fresco. Materiales y métodos. Se diseñaron iniciadores específicos para amplificar un fragmento conservado del virus de la fiebre amarilla. Un segundo par de iniciadores se usó en una reacción de amplificación anidada para incrementar la sensibilidad. Se probaron 33 muestras clínicas con la técnica estandarizada. Resultados. El amplímero esperado se obtuvo en 25 de las 33 muestras analizadas usando este método y 2 más resultaron positivas después de la reacción anidada. Conclusión. Esta técnica mejorada garantiza la detección de todos los genotipos virales de fiebre amarilla y puede incrementar la sensibilidad del ensayo introduciendo una segunda etapa de amplificación, lo cual permite el diagnóstico diferencial con infección por dengue y otros flavivirus, lo cual es de gran importancia para la vigilancia y la toma de medidas epidemiológicas oportunas. doi: http://dx.doi.org/10.7705/biomedica.v33i0.1452

  11. Fiebres virales hemorrágicas en Suramérica

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    Robert B. Tesh

    2002-09-01

    Full Text Available El artículo revisa la epidemiología y rasgos distintivos de tres fiebres virales hemorrágicas (dengue hemorrágico, fiebre amarilla y fiebre hemorrágica por arenavirus, que han emergido como serios problemas de salud pública en Suramérica. Aunque la etiología, la historia natural y el control de estas tres enfermedades difieren, sus manifestaciones clínicas y los hallazgos histopatológicos son similares y pueden ser difíciles de diferenciar. En consecuencia, la detección temprana y el diagnóstico correcto son esenciales para la aplicación de medidas de control.

  12. Presencia de Aedes (Stegomyia aegypti (Linnaeus, 1762 y su infección natural con el virus del dengue en alturas no registradas para Colombia

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    Freddy Ruiz-López

    2016-06-01

    Conclusión. Por primera vez se registró A. aegypti a 2.302 msnm, la mayor altitud registrada para este vector en Colombia. De igual forma, se encontró infección con el virus del dengue a 1.984 msnm. Estos hallazgos son significativos, ya que determinan regiones de Colombia con riesgo potencial de transmisión autóctona de dengue y otros arbovirus por A. aegypti.

  13. Manifestaciones mucocutáneas atípicas por fiebre por el virus del chikungunya en neonatos y lactantes de Cúcuta, Los Patios y Villa del Rosario, Norte de Santander, Colombia, 2014

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    Claudia Marcela Muñoz

    2016-09-01

    Full Text Available Introducción. Se han observado manifestaciones clínicas atípicas en recién nacidos y lactantes con fiebre por el virus del chikungunya. Objetivo. Describir los casos de fiebre causada por el virus del chikungunya en recién nacidos y lactantes con lesiones mucocutáneas atípicas. Materiales y métodos. Se revisaron las historias clínicas y los resultados de laboratorio y de patología en tres hospitales regionales de los casos de recién nacidos y lactantes diagnosticados con el virus del chikungunya que presentaban lesiones mucocutáneas atípicas; se hizo una búsqueda activa comunitaria en los barrios de residencia de los pacientes. Resultados. De 18 casos sospechosos de chikungunya en recién nacidos y lactantes, 11 pacientes con diagnóstico confirmado presentaron manifestaciones mucocutáneas atípicas. Seis de los 11 casos confirmados eran niños menores de cinco meses de edad. Los síntomas más frecuentes fueron: fiebre, eritema, irritabilidad y diarrea. Tres de los pacientes estaban infectados con dengue y chikungunya. Las úlceras se presentaron en cuero cabelludo, abdomen, región genital y perianal. En la búsqueda activa comunitaria se encontraron altas tasas de ataque de la enfermedad. Conclusiones. Se presenta un informe de las manifestaciones mucocutáneas en recién nacidos y lactantes diagnosticados con fiebre por el virus del chikungunya en Colombia. El rápido desarrollo de las úlceras se debe, probablemente, a la reacción inmunitaria al virus. Es necesario priorizar la atención de las mujeres embarazadas que presenten síntomas una semana antes del parto y hacerle seguimiento a los recién nacidos, para hacer el diagnóstico temprano del chikungunya y evitar complicaciones.

  14. Distribución geográfica del mono aullador rojo (Alouatta seniculus y la fiebre amarilla en Colombia

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    Juan Piedrahita-Cortés

    2016-08-01

    Conclusiones. En 69,5 % de los departamentos con antecedentes de fiebre amarilla se registró la presencia de A. seniculus, lo cual resulta relevante por el papel que los primates no humanos desempeñan como reservorio natural del virus y por su contribución en la presentación de la fiebre amarilla, lo cual les confiere gran utilidad como centinelas.

  15. Dengue neonatal en el Perú: Reporte de un caso Neonatal dengue in Peru: a case report

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    Hermann Silva Delgado

    2011-03-01

    Full Text Available Se presenta el caso de un neonato de sexo femenino, a término, producto de madre fallecida al séptimo día de su puerperio, por falla multiorgánica debido a dengue grave confirmado por detección de antígeno NS1 e IgM. La recién nacida (RN no tuvo complicaciones, pero a partir del cuarto día de vida desarrolló fiebre, ictericia, manifestaciones de extravasación de plasma, hepatomegalia, ascitis, plaquetopenia y otros signos de síndrome de respuesta inflamatoria sistémica. Su evolución final fue favorable con tratamiento instaurado. Se demuestra con PCR en tiempo real, la presencia del virus dengue serotipo 2 en sangre de la RN, confirmándose el primer caso de dengue neonatal reportado en el Perú.We present the case of a full-term female newborn, whose mother died seven days postpartum from multi-organ failure due to severe dengue confirmed by NS1 antigen detection and positive IgM. The newborn did not have any complication, but at the fourth day of life she developed fever, jaundice, signs of plasma leakage, thrombocytopenia, hepatomegaly, ascitis, and others signs of systemic inflammation response syndrome. She fully recovered with supportive treatment. The RT-PCR test of a peripheral blood sample revealed a positive result for the dengue virus serotype 2, confirming the first case of neonatal dengue reported in Peru.

  16. Factores de interés referentes a la colonización de Haemagogus Splendens para experimentos de transmisión con virus de fiebre amarilla en el Laboratorio Factores de interés referentes a la colonización de Haemagogus Splendens para experimentos de transmisión con virus de fiebre amarilla en el Laboratorio

    Directory of Open Access Journals (Sweden)

    Osorno-Mesa Ernesto

    1947-12-01

    Full Text Available 1 o Se amplia la distribución geográfica de Haemagogus splendens, conocida hasta hoy, anotando su papel importante como probable vector en la naturaleza. 2 o H. splendens es la especie del genero Haemagogus que biológicamente representa el eslabón entre este genero y Aedes, por la gran similitud de su comportamiento en el laboratorio, con A. aegypti. 3 o Es la especie de más fácil determinación por las hembras. 4 o Se da una técnica para el transporte y posturas de huevos de las hembras de mosquitos. 1o The known geographic distribution of Haemagogus splendens is extended, and its role as a probable vector in natural conditions is established. 2 o H. splendens of all the species of Haemaqogus, is the one that seems to constitute a biological link between that genus and the genus Aedes. (Based on the great similarity of behavior with Aedes aegypti under laboratory conditions. 3 o The identification of females is most easy. 4 o A technique for egg laying and transportation of the adults is described.

  17. Reacción en cadena de la polimerasa para la detección rápida y determinación del serotipo de virus del dengue en muestras clínicas

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    Rosario Delfina

    1998-01-01

    Full Text Available El trabajo que aquí se presenta describe las ventajas de usar la reacción en cadena de la polimerasa con transcriptasa inversa (RCP-TI para detectar e identificar con rapidez virus del dengue en muestras clínicas. Se sometieron directamente a RCP-TI 27 muestras obtenidas de pacientes con fiebre de dengue y fiebre hemorrágica de dengue durante epidemias en Colombia, Nicaragua y Panamá. El ADN de cadena doble obtenido con la RCP-TI se identificó mediante una segunda amplificación (RCP de anidación utilizando cebadores específicos para cada tipo de virus, aislamiento vírico e inmunofluorescencia indirecta (IFI y con electroinmunoensayo enzimático detector de anticuerpos IgM contra el virus del dengue. El genoma vírico amplificado se detectó e identificó en un máximo de 8 horas. Los parámetros calculados para hacer el diagnóstico por RCP-TI, usando el aislamiento vírico y la IFI como estándar de oro, fueron una sensibilidad de 100%; una especificidad de 78%; un valor predictivo positivo de 69% y un valor predictivo negativo de 100%. Cabe notar que dos de los especímenes que dieron resultados positivos a la prueba de RCP-TI anidada y negativos al aislamiento vírico mostraron anticuerpos específicos de tipo IgM. Los resultados de la RCP-TI en general mostraron una estrecha concordancia con los del aislamiento vírico, lo cual sugiere que la RCP es un procedimiento que facilita enormemente el diagnóstico rápido y temprano del dengue.

  18. Reacción en cadena de la polimerasa para la detección rápida y determinación del serotipo de virus del dengue en muestras clínicas

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    Delfina Rosario

    1998-07-01

    Full Text Available El trabajo que aquí se presenta describe las ventajas de usar la reacción en cadena de la polimerasa con transcriptasa inversa (RCP-TI para detectar e identificar con rapidez virus del dengue en muestras clínicas. Se sometieron directamente a RCP-TI 27 muestras obtenidas de pacientes con fiebre de dengue y fiebre hemorrágica de dengue durante epidemias en Colombia, Nicaragua y Panamá. El ADN de cadena doble obtenido con la RCP-TI se identificó mediante una segunda amplificación (RCP de anidación utilizando cebadores específicos para cada tipo de virus, aislamiento vírico e inmunofluorescencia indirecta (IFI y con electroinmunoensayo enzimático detector de anticuerpos IgM contra el virus del dengue. El genoma vírico amplificado se detectó e identificó en un máximo de 8 horas. Los parámetros calculados para hacer el diagnóstico por RCP-TI, usando el aislamiento vírico y la IFI como estándar de oro, fueron una sensibilidad de 100%; una especificidad de 78%; un valor predictivo positivo de 69% y un valor predictivo negativo de 100%. Cabe notar que dos de los especímenes que dieron resultados positivos a la prueba de RCP-TI anidada y negativos al aislamiento vírico mostraron anticuerpos específicos de tipo IgM. Los resultados de la RCP-TI en general mostraron una estrecha concordancia con los del aislamiento vírico, lo cual sugiere que la RCP es un procedimiento que facilita enormemente el diagnóstico rápido y temprano del dengue.

  19. Fiebre de origen desconocido, una forma de presentarse la tuberculosis

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    Lázaro Arturo Vidal Tallet

    2012-12-01

    Full Text Available La tuberculosis es una causa importante de fiebre de origen desconocido. Dentro de los factores de riesgo para estar infectado por el bacilo tuberculoso se encuentra la edad, la presencia de comorbilidades, la competencia inmunológica y la alta prevalencia de la enfermedad en el área geográfica. Los hallazgos clínicos, radiológicos, epidemiológicos y la respuesta a la terapéutica antimicrobiana, pueden orientar en el diagnóstico de esta enfermedad infecciosa. Se presenta un caso en el que los elementos clínicos y epidemiológicos (padre con diagnóstico de tuberculosis llevaron finalmente a la sospecha diagnóstica de tuberculosis extra pulmonar, que no pudo ser demostrada por cultivo, pero la respuesta terapéutica resultó concluyente, ya que, una vez iniciada esta, hubo total remisión del cuadro clínico y recuperación nutricional. La terapia antituberculosa con carácter terapéutico y diagnóstico debe ser considerada en todo paciente con fiebre de origen desconocido, que, además, presente elementos clínicos y epidemiológicos que justifiquen la posibilidad de infección por el bacilo.

  20. Epidemiología molecular de la fiebre amarilla en Colombia: análisis filogenético

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    Jorge Boshell

    2004-03-01

    fragmentos de 569 pb correspondiente a la región de unión de los genes E/ NS1, (7,8 los cuales fueron purificados y secuenciados en un secuenciador automático Abiprism 310 (Applied Biosystem; las secuencias generadas se alinearon con el programa CLUSTAL W donde además se generaron los árboles filogenéticos que posteriormente se visualizaron en el programa Treview.

    Los análisis preliminares indican un porcentaje de homología cercano al 97% entre las cepas analizadas, lo cual refleja la estabilidad genética del virus a través del tiempo, y nos permite pensar que los brotes recientemente ocurridos obedecen al incremento de la actividad selvática del virus, con el humano como huésped accidental al intervenir con su ecosistema, más que a la reintroducción de nuevas cepas de mayor virulencia (9-12.

     

    REFERENCIAS

    1. GROOT H, BOSHELL J. Dengue, dengue hemorrágico y fiebre amarilla. En: CHALEM F, ESCANDÓN JE, CAMPOS J, ESGUERRA R, editores. Medicina interna. Bogotá. Doyma Andina S.A.; 1992: 1389-1395.

    2. MONATH TP. Yellow fever: an update. Lancet Inf Dis 2001; 1:11-20.

    3. TESH R. Viral hemorrhagic fevers of South America. Biomédica 2002; 22:287-295.

    4. BARROS MLB, BOECKEN G. Jungle yellow fever in the central amazon. Lancet 1996; 348:969-970.

    5. GROOT H, MORALES A, ROMERO M

  1. Resumen de notas históricas sobre la fiebre amarilla en Colombia

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    Hernando Groot

    2004-03-01

    Full Text Available

    Dos formas epidemiológicas, la urbana y la selvática, de hecho íntimamente ligadas. En cuanto a la primera, transmitida de hombre a hombre por Aedes aegypti, debe recordarse que se observaba frecuentemente en los poblados de la costa del Caribe desde el siglo XVII, produciendo a veces epidemias como la que sufrieron las tropas de Vernon en 1741 cuando al intentar tomar a Cartagena se vieron atacadas por la enfermedad; de los 23.000 invasores, 9.000 perecieron en la empresa, la mayoría de ellos por causa de la fiebre amarilla. En épocas más recientes durante el siglo XIX y a principios del XX, el mal siguió siendo azote común del litoral Atlántico y causó también diversas epidemias a lo largo del Río Magdalena y en algunas poblaciones aisladas, como El Carmen y Ocaña. Igualmente se registraron casos de la enfermedad en Buenaventura. Las dos últimas epidemias urbanas que sufrió Colombia, fueron las de Bucaramanga en 1923 y la del Socorro en 1928. Es de notar que la desaparición de la fiebre amarilla de las ciudades se debió sin duda a las vigorosas campañas para eliminar el mosquito transmisor que culminaron en 1960 con su erradicación, exceptuada Cúcuta. Sin embargo, años más tarde el país se reinfestó con el Aedes y, por consiguiente, quedó nuevamente expuesto a las epidemias de fiebre amarilla urbana, pero con riesgo mayor por cuanto el mosquito se había dispersado por todo el país y se había establecido en lugares donde nunca había existido antes. Afortunadamente hasta el momento actual no se ha presentado brote alguno del famoso vómito negro urbano.

    En cambio se han observado gigantescas epidemias de dengue (1.

    En lo referente a la fiebre amarilla selvática lo primero por indicar es que

  2. Dengue in Grenada El dengue en el país de Granada

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    André Panagos

    2005-04-01

    objetivo del presente estudio fue evaluar la situación del dengue en una comunidad representativa de ese país. MÉTODOS: Se llevaron a cabo encuestas en la zona del valle de Mont Tout y de Grand Anse, en la parroquia de St. George's, de marzo a junio de 1996. Los objetivos de las encuestas fueron: 1 explorar los conocimientos, actitudes y prácticas (CAP de los habitantes; 2 determinar la presencia de formas larvarias y adultas de Aedes aegypti en posibles criaderos, y 3 identificar la seroprevalencia de inmunoglobulina G (IgG con actividad específica contra el virus del dengue en la población local. RESULTADOS: De las 102 personas que respondieron la encuesta de CAP, 100 (98% indicaron que nunca habían padecido de fiebre del dengue. De las 75 personas que consintieron que se les sacaran muestras de sangre, 70 (93% (intervalo de confianza de 95% = 85,1%-97,8% tuvieron resultados positivos en la prueba de inmunoadsorción enzimática para la detección de IgG, señal de que habían tenido una exposición anterior. En lo que respecta al almacenamiento del agua, 98 de las 102 personas (96% encuestadas almacenaban agua fresca en recipientes. La encuesta de vectores reveló que en 57 de las 102 viviendas (56% había larvas de Ae. Aegypti en recipientes de agua en la propiedad, y en 94 de las 102 viviendas (92% se encontraron mosquitos Ae. aegypti adultos en el interior. CONCLUSIONES: A pesar de que muchas personas estaban familiarizadas con la fiebre del dengue y el mosquito vector, la encuesta de 1996 reveló en ellas conocimientos incompletos acerca de las relaciones importantes entre los mosquitos, los hábitos del ser humano y la transmisión de la enfermedad. Desde 1996 se han puesto en marcha de continuo iniciativas educativas en las escuelas públicas y mediante campañas sanitarias a escala nacional, pero pocas han estado dirigidas específicamente a la comunidad aquí estudiada. Estos datos indican que el país de Granada necesita un sistema de educaci

  3. Respuesta neuroinmunológica en la encefalitis asociada al virus del dengue

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    Bárbara Padilla-Docal

    2013-12-01

    Full Text Available El virus del dengue es un virus ARN miembro de la familia Flaviviridae, la cual incluye, además, el de la fiebre amarilla, el del Nilo del Oeste y la encefalitis japonesa. Se realizó un estudio retrospectivo con tres pacientes diagnosticados de encefalitis asociada al dengue, en cuyas muestras de suero y líquido cefalorraquídeo se cuantificaron los niveles de las clases mayores de inmunoglobulinas por inmunodifusión radial y la manosa de unión a lectina, proteína de la vía de las lectinas del sistema del complemento por fluorometría. En el reibergrama se muestra la presencia de síntesis intratecal de las tres clases de inmunoglobulinas y ausencia de síntesis intratecal de lectina de unión a manosa. Existieron diferencias en cuanto al por ciento de síntesis intratecal de inmunoglobulinas, las cuales estuvieron relacionadas con el momento de la infección por el virus y la aparición de las manifestaciones neurológicas compatibles con una encefalitis. Este es el primer reporte de afectaciones neurológicas en pacientes cubanos con dengue. La respuesta inmune intratecal puede ser utilizada para el mejor conocimiento de la enfermedad y contribuir al desarrollo de posibles candidatos vacunales.

  4. La epidemiología del dengue y del dengue hemorrágico en Santiago de Cuba, 1997 The epidemiology of dengue and dengue hemorrhagic fever in Santiago de Cuba, 1997

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    Luis Valdés

    1999-07-01

    Full Text Available En 1977, Cuba informó de su primera epidemia de dengue, durante la cual se registraron más de 500 000 casos de fiebre del dengue causados por el serotipo 1 del virus. En 1981, se produjo una gran epidemia de dengue hemorrágico causada por el serotipo 2. Esa vez se notificaron 344 203 casos en total, 10 312 casos clínicos de dengue hemorrágico y 158 defunciones, de las cuales 101 correspondieron a niños. Por medio de una búsqueda activa con confirmación de laboratorio, en el municipio de Santiago de Cuba de la provincia del mismo nombre se detectó precozmente en enero de 1997 la reintroducción del dengue, específicamente del virus del tipo 2, genotipo Jamaica. En este trabajo se presentan los aspectos epidemiológicos de mayor interés referentes a esa epidemia. Se notificaron 3 012 casos confirmados por serología, 205 clasificados como fiebre hemorrágica del dengue/síndrome de choque del dengue, de los cuales 12 fallecieron (todos adultos. La infección secundaria por virus del dengue fue uno de los principales factores de riesgo en el desarrollo de dengue hemorrágico y 98% de los casos, así como 92% de los fallecidos, manifestaron una respuesta de tipo secundario. Por primera vez se observó la posibilidad de contraer dengue hemorrágico en personas con una infección secundaria de 16 a 20 años después de la primera infección. Pertenecer a la raza blanca fue otro factor de riesgo de importancia, tal como se había observado desde la epidemia de 1981. En la última epidemia se demostró que la llamada “alerta de fiebre” no es útil para la detección temprana de una epidemia. Las medidas tomadas por las autoridades sanitarias del país evitaron la extensión de la epidemia a otros municipios que estaban infestados por Aedes aegypti.A dengue epidemic that Cuba reported in 1997 registered more than 500 000 cases of dengue fever produced by viral serotype 1. In 1981, there was an epidemic of dengue hemorrhagic fever produced by

  5. Vaccines against dengue: a review of current candidate vaccines at advanced development stages Vacunas contra el dengue: una revisión de las vacunas candidatas en etapas avanzadas de desarrollo

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    Joachim Hombach

    2007-04-01

    Full Text Available Los esfuerzos sistemáticos para desarrollar una vacuna contra el dengue comenzaron durante la Segunda Guerra Mundial, inspirados en el desarrollo exitoso de una vacuna contra la fiebre amarilla. Sin embargo, la falta de modelos adecuados de la enfermedad, la información incompleta acerca de los mecanismos patogénicos y los insuficientes incentivos económicos han dificultado los avances. Debido al impacto actual del dengue en todo el mundo y su explosiva diseminación, ha aumentado el interés en el desarrollo de vacunas contra el dengue y se ha avanzado considerablemente en el camino hacia la evaluación clínica de vacunas candidatas. La Iniciativa para la Investigación en Vacunas, de la Organización Mundial de la Salud, está facilitando el desarrollo de y los ensayos con las vacunas candidatas. Las vacunas contra el dengue que se encuentran actualmente en etapas avanzadas de desarrollo son de tres tipos fundamentales: 1 vivas atenuadas; 2 vivas recombinantes; y 3 de subunidades e inactivadas. La mayoría de las vacunas en cartera son vivas atenuadas, siguiendo el camino exitoso de otras vacunas vivas contra flavivirus, especialmente de la desarrollada contra la fiebre amarilla. En general, las vacunas contra el dengue que se encuentran actualmente en desarrollo están bastante avanzadas y son muy diversas. Muy pronto comenzará la evaluación de estas vacuna candidatas en ensayos de eficacia basados en poblaciones expuestas, lo que requerirá resolver varios problemas técnicos, operacionales y regulatorios.

  6. Dengue in Nicaragua, 1994: reintroduction of serotype 3 in the Americas Dengue en Nicaragua, 1994: reintroducción del serotipo 3 en las Américas

    Directory of Open Access Journals (Sweden)

    María G. Guzmán

    1997-03-01

    total 356 muestras de suero obtenidas por medio del sistema nicaragüense de vigilancia del dengue durante una epidemia en octubre de 1994. En 43% de las muestras se detectaron anticuerpos IgM contra el dengue y los sueros de 12 de las 18 áreas atendidas por los sistemas locales integrales de salud dieron resultados positivos. Además, se aislaron virus de dengue en 5 de 24 sueros de pacientes con síntomas hemorrágicos: en 3 se aisló el serotipo 3 y en 2, el serotipo 1. Mediante pruebas de laboratorio, en 26 de 39 pacientes hospitalizados en León y Managua se consideró probable o se confirmó el diagnóstico de dengue con manifestaciones hemorrágicas o dengue hemorrágico. En 18 pacientes diagnosticados de dengue con manifestaciones hemorrágicas, los síntomas más comunes fueron fiebre, cefalea, vómito, mialgia, artralgia y epistaxis. Los ocho pacientes restantes, en los que se diagnosticó dengue hemorrágico probable, tuvieron fiebre, malestar general, hemorragias, trombocitopenia y hemoconcentración, y los títulos de anticuerpos a la prueba de inhibición de la hemaglutinación oscilaron de 640 a 20 480. Se confirmó así la reintroducción del serotipo 3 del dengue en la Región y su capacidad para producir casos de dengue hemorrágico. En Nicaragua, por lo menos, es evidente que la reintroducción del serotipo 3 del dengue ha producido un aumento de los casos de dengue clásico y dengue hemorrágico. Si no se presta atención urgente al control del mosquito vector de la enfermedad, la experiencia descrita podría constituir el preludio lúgubre de futuros acontecimientos similares en las Américas.

  7. Fiebre entérica en fase de fastigium: notas epicríticas acerca de un caso de autopsia

    OpenAIRE

    Salazar Morales, Miguel Fernando; Estrada Hernández, María del Rocío; Parraguirre Martínez, Sara

    2012-01-01

    La fiebre tifoidea es una enfermedad sistémica de etiología infecciosa ocasionada por el bacilo gramnegativo Salmonella typhi. Se presenta el caso de una mujer de 19 años quien comenzó con fiebre, dolor abdominal y diarrea; posteriormente cursó con insuficiencia hepática, necrosis tubular aguda, rabdomiolisis y trombocitopenia. Falleció a los 3 días del ingreso hospitalario. Los hallazgos de autopsia fueron: ulceración de placas de Peyer, inflamación y necrosis de ganglios linfáticos mesentér...

  8. Iatrogenia institucional y muerte materna. Semmelweis y la fiebre puerperal

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    Oswaldo Salaverry García

    Full Text Available La fiebre puerperal es una enfermedad que asume carácter epidémico en el siglo XVIII como consecuencia de dos factores: las masas trabajadoras urbanas generadas por la revolución industrial, y la progresiva hegemonización y medicalización de la atención del parto en grandes hospitales públicos. La mortalidad materna institucionalizada alcanza cifras superiores al 30%, en tanto con la atención por parteras es menor al 2%. Semmelweis, médico húngaro, postula que los médicos contaminaban a las parturientas por insuficiente higiene luego de realizar necropsias, e implanta medidas profilácticas en el Hospital de Viena, las cuales reducen dramáticamente la mortalidad, pero sus ideas son rechazadas por que afectan el proceso de institucionalización de la medicina basado en el altruismo y honor, por los que supuestamente era imposible que causen daño a sus pacientes. Es obligado a retirarse del Hospital de Viena, y continua su lucha en Budapest, pero el rechazo y la incomprensión de sus colegas por su doctrina afecta su salud mental. Muere en un asilo, pocos años antes que Pasteur y Koch demuestren las bacterias causantes de enfermedades como la fiebre puerperal.

  9. Iatrogenia institucional y muerte materna: semmelweis y la fiebre puerperal

    Directory of Open Access Journals (Sweden)

    Oswaldo Salaverry García

    Full Text Available La fiebre puerperal es una enfermedad que asume carácter epidémico en el siglo XVIII como consecuencia de dos factores: las masas trabajadoras urbanas generadas por la revolución industrial, y la progresiva hegemonización y medicalización de la atención del parto en grandes hospitales públicos. La mortalidad materna institucionalizada alcanza cifras superiores al 30%, en tanto con la atención por parteras es menor al 2%. Semmelweis, médico húngaro, postula que los médicos contaminaban a las parturientas por insuficiente higiene luego de realizar necropsias, e implanta medidas profilácticas en el Hospital de Viena, las cuales reducen dramáticamente la mortalidad, pero sus ideas son rechazadas por que afectan el proceso de institucionalización de la medicina basado en el altruismo y honor, por los que supuestamente era imposible que causen daño a sus pacientes. Es obligado a retirarse del Hospital de Viena, y continua su lucha en Budapest, pero el rechazo y la incomprensión de sus colegas por su doctrina afecta su salud mental. Muere en un asilo, pocos años antes que Pasteur y Koch demuestren las bacterias causantes de enfermedades como la fiebre puerperal.

  10. Desarrollo de agentes inmunizantes contra el dengue

    Directory of Open Access Journals (Sweden)

    Francisco J. López Antuñano

    2000-05-01

    Full Text Available El complejo de los cuatro flavivirus del dengue es transmitido principalmente por el mosquito Aedes aegypti. Se han atribuido epidemias a la actividad de A. albopictus, A. polynesiensis y a varias especies del complejo A. scutellaris. Los factores de riesgo que determinan la probabilidad de enfermar o morir por dengue están relacionados tanto con el huésped (características genéticas, estado inmunitario, forma de vida y condiciones de salud, saneamiento básico de la vivienda y abastecimiento de agua potable como con el virus (variabilidad genética de cepas entre y dentro de los serotipos, diferente capacidad patógena y distribución geográfica. A pesar de la falta de conocimiento sobre la inmunobiopatología del dengue, se han hecho importantes avances para conseguir una respuesta inmunitaria protectora con virus atenuados y con antígenos obtenidos por medio de tecnologías recombinantes. Desde los años 40, se ha intentado desarrollar vacunas contra el dengue. La inmunidad que se adquiere por infección natural es específica para cada serotipo y se han documentado infecciones por tres serotipos diferentes en la misma persona, por lo que probablemente sea necesaria una vacuna tetravalente. En voluntarios se han probado vacunas contra los cuatro serotipos que han sido inmunógenas y seguras. Aunque las vacunas con virus atenuados son prometedoras, son necesarios nuevos estudios sobre su eficacia y seguridad. Actualmente están en curso estudios para producir vacunas contra el virus del dengue mediante tecnologías de ADN recombinante y otras técnicas de biología molecular, utilizando como antígenos proteínas estructurales (principalmente la glicoproteína E y no estructurales. Con el mismo propósito se han usado varios vectores de expresión, como Escherichia coli, baculovirus, virus de la vacuna y virus de la fiebre amarilla. Lamentablemente, no se han obtenido resultados satisfactorios en el hombre. La necesidad de desarrollar

  11. Dengue perinatal

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    Doris Martha Salgado

    2013-08-01

    Full Text Available El dengue es en la actualidad la enfermedad viral más relevante de transmisión vectorial hiperendémica en las Américas. El incremento en el número de casos se ha relacionado con la aparición de dengue durante la gestación y en el periodo neonatal. De acuerdo con la edad de gestación en la que ocurra la infección, podrían presentarse manifestaciones en el feto, como aborto, y en los pacientes a término,dengue neonatal. En este artículo se presenta una reseña de los casos reportados a nivel mundial, y especialmente en las Américas, así como aspectos fisiopatogénicos de la enfermedad.   doi: http://dx.doi.org/10.7705/biomedica.v33i0.1449

  12. Validez del tacto materno en el reconocimiento de fiebre en niños menores de 36 meses

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    María Velásquez-Espíritu

    2010-10-01

    Full Text Available Objetivo: Determinar la validez del tacto materno como método de detección de la presencia o no de fiebre en los niños. Material y métodos: Se seleccionaron por conveniencia a 269 madres y sus respectivos niños menores de 36 meses que acudieron al Servicio de Emergencias Pediátricas del Hospital Nacional Cayetano Heredia por cualquier molestia. Se preguntó a las madres si su niño presentaba fiebre o no (detectado por tacto, y luego se procedió con la medición de la temperatura rectal de cada niño. Resultados: Se incluyeron 269 participantes. El tacto materno para la detección de fiebre tuvo una sensibilidad de 79,3% (69,6% a 86,5%, especificidad 91,8% (86,8% a 94,9%, VPP 82,1% (72,6% a 88,9% y VPN 90,3% (85,1% a 93,8%; el likelihood ratio positivo fue 9,62 (5,86 a 15,81 y el likelihood ratio negativo fue 0,23 (0,15 a 0,34. La correlación (índice Kappa de fiebre o no fiebre determinada por la madre y la medida por termómetro fue de 0,72 (p:0,0000. Conclusiones: Las madres tienen una buena capacidad discriminativa en la determinación de la presencia o ausencia de fiebre mediante la palpación, por lo que la detección de fiebre por tacto materno es un eficiente método de despistaje.(Rev Med Hered 2010;21:175-179

  13. Fiebre amarilla en Africa: su impacto en salud pública y perspectivas para su control en el siglo XXI

    OpenAIRE

    Oyewale Tomori

    2002-01-01

    Durante las últimos dos décadas, la fiebre amarilla ha vuelto a emerger con fuerza hasta constituirse en un grave problema de salud pública en Africa, trayendo indecibles sufrimientos a mucha de su población y convirtiéndose en un obstáculo más para su desarrollo social y económico. A pesar de los destacados logros alcanzados en el conocimiento de la epidemiología de esta enfermedad y de la disponibilidad de una vacuna segura y eficaz, la fiebre amarilla continúa siendo un serio problema de s...

  14. Características de los exámenes de laboratorio en pacientes con dengue grave en un hospital de Puerto Maldonado - Perú

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    Jesús Rojas-Jaimes

    2014-07-01

    Full Text Available Introducción: Puerto Maldonado, capital del Departamento de Madre de Dios, es catalogado como zona endémica de dengue. La clasificación de dengue considera al dengue grave (hemorrágico cuando se produce shock, distrés respiratorio o compromiso de órgano blanco. Objetivos: Determinar las características de los exámenes de laboratorio en pacientes con dengue grave hospitalizados en la Unidad de Cuidados Intermedios del Hospital Santa Rosa de Puerto Maldonado, Madre de Dios, Perú. Diseño: Estudio retrospectivo de corte transversal. Institución: Laboratorio Central y Departamento de Epidemiología del Hospital Santa Rosa, Madre de Dios, Perú. Materiales: Cincuenta y cinco historias clínicas de pacientes con diagnóstico de dengue grave hospitalizados en la Unidad de Cuidados Intermedios, en el periodo junio de 2010 a noviembre de 2011. Métodos: Se analizó los resultados de exámenes de laboratorio solicitados durante la hospitalización. Principales medidas de resultados: Valores de transaminasas, creatinina, hemograma completo y examen de orina. Resultados: El mayor número de pacientes con dengue grave procedió de Puerto Maldonado (84%. El grupo etario mayormente afectado fue el de 40 a 49 años (32%. En 83% de los pacientes hospitalizados se presentó elevación de las transaminasas y de la creatinina sérica. El recuento de plaquetas estuvo dentro de rangos normales, excepto en el grupo de 10 a 19 años (11%, en quienes se halló concentraciones séricas de plaquetas menores a 150 000/mL. Conclusiones: En la mayoría de pacientes hospitalizados por dengue grave en Puerto Maldonado existió elevación sérica de transaminasas y creatinina. El recuento de plaquetas fue normal, pero existió plaquetopenia en el grupo de 10 a 19 años.

  15. Desarrollo de agentes inmunizantes contra el dengue Development of immunizing agents against dengue

    Directory of Open Access Journals (Sweden)

    Francisco J. López Antuñano

    2000-05-01

    Full Text Available El complejo de los cuatro flavivirus del dengue es transmitido principalmente por el mosquito Aedes aegypti. Se han atribuido epidemias a la actividad de A. albopictus, A. polynesiensis y a varias especies del complejo A. scutellaris. Los factores de riesgo que determinan la probabilidad de enfermar o morir por dengue están relacionados tanto con el huésped (características genéticas, estado inmunitario, forma de vida y condiciones de salud, saneamiento básico de la vivienda y abastecimiento de agua potable como con el virus (variabilidad genética de cepas entre y dentro de los serotipos, diferente capacidad patógena y distribución geográfica. A pesar de la falta de conocimiento sobre la inmunobiopatología del dengue, se han hecho importantes avances para conseguir una respuesta inmunitaria protectora con virus atenuados y con antígenos obtenidos por medio de tecnologías recombinantes. Desde los años 40, se ha intentado desarrollar vacunas contra el dengue. La inmunidad que se adquiere por infección natural es específica para cada serotipo y se han documentado infecciones por tres serotipos diferentes en la misma persona, por lo que probablemente sea necesaria una vacuna tetravalente. En voluntarios se han probado vacunas contra los cuatro serotipos que han sido inmunógenas y seguras. Aunque las vacunas con virus atenuados son prometedoras, son necesarios nuevos estudios sobre su eficacia y seguridad. Actualmente están en curso estudios para producir vacunas contra el virus del dengue mediante tecnologías de ADN recombinante y otras técnicas de biología molecular, utilizando como antígenos proteínas estructurales (principalmente la glicoproteína E y no estructurales. Con el mismo propósito se han usado varios vectores de expresión, como Escherichia coli, baculovirus, virus de la vacuna y virus de la fiebre amarilla. Lamentablemente, no se han obtenido resultados satisfactorios en el hombre. La necesidad de desarrollar

  16. Dengue Epidemiology

    Science.gov (United States)

    ... and dengue shock syndrome (DSS). Transmission of the Dengue Virus Dengue is transmitted between people by the ... the vectors is too infrequent to sustain transmission. Dengue is an Emerging Disease The four dengue viruses ...

  17. Caracterización clínica de los casos de dengue hospitalizados en la E.S.E. Hospital ""Antonio Roldán Betancur"", Apartadó, Antioquia, Colombia, 2000.

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    Margarita Arboleda

    2006-06-01

    Full Text Available Introducción. Desde 1998 se vienen notificando casos de dengue hemorrágico en el municipio de Apartadó y actualmente el dengue se considera endemo-epidémico. Objetivo. Describir el comportamiento clínico del dengue en pacientes hospitalizados por esta causa en la Empresa Social del Estado Hospital Antonio Roldán Betancur de Apartadó en el año 2000. Materiales y métodos. Estudio descriptivo retrospectivo de revisión de historias clínicas de pacientes hospitalizados por dengue. Resultados. Se hospitalizaron 45 casos con diagnóstico serológico de dengue. Tres (6,7% pacientes con dengue clásico, 22 (48,9% con dengue con manifestaciones hemorrágicas y 20 (44,4% con dengue hemorrágico. La edad osciló entre 4 meses y 68 años con un promedio de 22,1 años. La mayoría procedía del área urbana (82,8%. Las manifestaciones clínicas más frecuentes fueron: fiebre (100%, mialgias y artralgias (71,1%, cefalea (70,5% y dolor abdominal (67,5%. Las manifestaciones hemorrágicas más frecuentes fueron petequias (60%, hematuria (31,7%, equimosis en sitios de venopunción (24,4%, melenas (22,2%, hematemesis (15,5% y hemorragias vaginales anormales (15,5%. El recuento de plaquetas osciló entre 11.000 y 186.000/mm3, con un promedio de 48.688. Los hematocritos oscilaron entre 26 y 59%, con un promedio de 41,5%. Fallecieron 4 (8,8% pacientes, tres de éstos menores de un año. En el 40% de los casos se hicieron otros diagnósticos simultáneamente, siendo malaria la coinfección más frecuente, con 17,7% (8/45 de los casos. Conclusión. En este estudio las personas en edad productiva tuvieron mayor riesgo de sufrir dengue y la población menor de un año fue la de mayor riesgo de letalidad; existe, además, la posibilidad de coinfección con otras enfermedades, particularmente malaria.

  18. Aumento de consultas en atención primaria por infección respiratoria de vías altas y por fiebre coincidiendo con la gripe (H1N1 2009

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    Pablo Aldaz

    2011-01-01

    Full Text Available Fundamento: En verano de 2009 se registró en Navarra una onda de gripe A (H1N1 2009. Evaluar su repercusión en consultas de atención primaria con diagnóstico diferente al de gripe. Métodos: Estudiamos las consultas en atención primaria del Servicio Navarro de Salud desde el 21 de junio y al 21 de septiembre de 2009 con diagnósticos de gripe (Clasificación Internacional de Atención Primaria, código R80, síndrome febril (código A03, infección respiratoria aguda de vías altas (código R74 y bronquitis aguda (código R78, y las comparamos con las registradas en el mismo periodo en los tres años previos. Resultados: En verano de 2009 se notificaron 3417 casos de síndrome gripal (5,5 por 1.000 habitantes. Entre las semanas 27 y 31 se produjo un brote de gripe, con más de la mitad (87/160 de los frotis de pacientes con síndrome gripal positivos para el virus (H1N1 2009 sin detectarse otros tipos de virus gripal. Coincidiendo con la onda de síndromes gripales observamos aumentos de consultas por síndrome febril e infección respiratoria de vías altas. En comparación con la media de los tres años anteriores, en el verano del 2009 se produjo un incremento del 44! en consultas por síndrome febril (de 3,6 a 5,3 por 1000: p<0,001, del 6! en consultas por infección de vías altas (de 13,2 a 14,1 por 1000; p<0,001 y del 8! en consultas por bronquitis aguda (de 6,3 a 6,9 por 1000; p=0,003. Estos diagnósticos supusieron 3,2 consultas adicionales por 1.000 habitantes atribuibles a la gripe, es decir, un 58! de consultas adicionales. Conclusiones: La gripe se acompaña de aumento en el número de consultas por síndrome febril y por infección respiratoria de vías altas.

  19. Manifestaciones clínicas y hallazgos de laboratorio de una serie de casos febriles agudos con diagnóstico presuntivo de infección por el virus dengue. Quindío (Colombia

    Directory of Open Access Journals (Sweden)

    Carlos Andrés Rodríguez-Salazar

    Full Text Available Objetivo: Describir las manifestaciones clínicas y hallazgos de laboratorio de una serie de casos febriles agudos con diagnóstico presuntivo de infección por el virus dengue. en Quindío (Colombia. Materiales y métodos: Se realizó un estudio de corte transversal, en pacientes con sospecha clínica de dengue en el periodo comprendido entre enero y agosto de 2013, en algunos centros hospitalarios del departamento del Quindío. Se tomaron muestras de sangre para diagnóstico de dengue, leptospira, malaria, hepatitis B, y rickettsiosis. Como pruebas confirmatorias para dengue se realizó aislamiento viral en células C6/36HT y serotipificación para dengue por RTPCR; pruebas de función hepática, cuadro hemático y niveles de citocinas. Resultados: Se caracterizaron 149 casos, de los cuales el 43% presentaron infección por dengue, 4% leptospira, 6,8% rickettsias, un caso de malaria y uno de hepatitis B. En 5 casos se logró el aislamiento del DENV2 y DENV3. Mediante la RT-PCR, se evidenció cocirculación de serotipos 2, 3, 4. Se encontró que las enzimas AST/ALT, el conteo de plaquetas, la erupción y el dolor abdominal fueron marcadores característicos de la infección por dengue, mientras la ictericia y el dolor lumbar se correlacionaron con la leptospirosis. Los valores de citocinas mostraron que la IL-10, TNF α variaron significativamente en casos con dengue frente a otros diagnósticos, y la IL-17 a presentó diferencias significativas en individuos con dengue grave. Conclusiones: El dengue se confirmó como causa etiológica importante de síndrome febril icterohemorrágico en el departamento del Quindío, pero la leptospirosis y la rickettsiosis tienen también una participación importante. Sin embargo, en el 44% de los casos fueron catalogados como síndrome febril indeterminado.

  20. Fiebre amarilla en Mazatlán, 1883

    OpenAIRE

    Javier E. García de Alba García; Ana L. Salcedo Rocha

    2006-01-01

    A propósito de una serie de telegramas emitidos durante la epidemia de fiebre amarilla de 1883 en Mazatlán, reproducidos en el semanario médico de la ciudad de México La Voz de Hipócrates, se hace una reflexión histórico-epidemiológica sobre el desarrollo de la fiebre amarilla en esta área del país y acerca del conocimiento prevaleciente.

  1. Dengue con signos de alarma: reporte de caso y plan de cuidados de enfermería

    Directory of Open Access Journals (Sweden)

    Mayra Mora-Merchan

    2011-12-01

    Full Text Available Introducción: El dengue es una enfermedad viral aguda, producida por el virus del dengue, transmitida por el mosquito Aedes aegypti, que se cría en el agua acumulada en recipientes y objetos en desuso .Existen cuatro serotipos del virus del dengue: 1, 2, 3 y 4. La primera vez que una persona es contagiada por cualquiera de estos cuatro virus, adquiere el dengue clásico. Nunca volverá a padecer dengue por el mismo virus pero sigue expuesta a los demás serotipos(1.Es una necesidad que el personal de enfermería tenga conocimientos claros del curso y clínica de la enfermedad para que así haya una atención temprana ante una enfermedad que avanza rápidamente en la comunidad. Materiales y Métodos: Artículo de Reporte de Caso sobre un paciente de 7 años que acude al servicio de urgencias en una Institución de salud en la ciudad de Bucaramanga (Santander. Resultados: Ante éste caso se decidió hacer una planeación del cuidado de enfermería para brindarle al menor teniendo en cuenta el momento de la enfermedad desde su ingreso hasta el alta hospitalaria y el seguimiento a nivel domiciliario, Se realizaron actividades de enseñanza del proceso de la enfermedad describiendo signos y síntomas, proceso, etiología, y las posibles complicaciones crónicas de la enfermedad. Discusión y Conclusiones: Al finalizar nuestro artículo nos hemos dado cuenta que hasta el momento ningún país ha logrado la erradicación total del vector del dengue, pero creemos que el control de las epidemias puede lograrse, controlando los vectores mediante campañas de fumigación, campañas de educación de la población y también de saneamiento del medio ambiente. (Rev Cuid 2011; 2(2: 202-5 .Palabras clave: Dengue, Aedes, Diagnóstico de Enfermería. (Fuente: DeCS BIREME.

  2. The health and economic impact of dengue in Latin America El impacto sanitario y económico del dengue en Latinoamérica

    Directory of Open Access Journals (Sweden)

    Jaime R. Torres

    2007-01-01

    investigación y control del dengue merecen niveles de prioridad semejantes a las de otras enfermedades en términos de asignación de recursos. Los datos son escasos sobre los análisis de coste-eficacia y coste-beneficio de los programas de control del dengue en Latinoamérica; sin embargo, parece ser bajo el coste por AVAI evitado a través de programas de control durante períodos endémicos, en comparación con otras enfermedades transmitidas por mosquitos, como la fiebre amarilla, leishmaniasis o malaria. Asimismo, ya se comprobó la correlación positiva coste-beneficio de los programas de control.

  3. Notas sobre fiebre amarilla en Colombia

    Directory of Open Access Journals (Sweden)

    Luis Patiño Camargo

    1937-09-01

    Full Text Available I-Introducción ll.-Datos clínicos anteriores al período de las investigaciones de laboratorio. Época colonial. III-Período de laboratorio anterior al descubrimiento de los animales receptivos. IV.-Período posterior al descubrimiento de los animales receptivos y a la prueba de protección. V.-Trabajos en Colombia durante el período de las investigaciones. VI. El servicio de fiebre amarilla cooperativo entre el Departamento Nacional de Higiene y la Fundación Rockejeller. VIl.-Consideraciones generales. VIlI.-Conclusiones. IX-Recomendaciones. X. Agradecimientos. XI.-Bibliografía. XIl.-Anexos. Legislación sobre viscerotomía. Es de fundamental interés para la vida de la República el estudio y solución de los problemas que se refieren a la salud de sus habitantes; y como el territorio colombiano es cálido en su mayoría, lógicamente se concluye que los asuntos de patología tropical han de ser los primeros en orden de importancia. La fiebre amarilla ha revestido graves caracteres epidémicos en repetidas épocas y por su condición endémica en anchas zonas del territorio colombiano, es una constante amenaza pública; un estudio para conocer su historia, la aparición de los brotes epidémicos, su distribución geográfica, la incidencia de morbosidad y Ietalidad, la localización precisa y la extensión de los territorios afectados, las fuentes del virus y los agentes transmisores, así como la preparación de planes y programas de lucha contra el flagelo, son cuestiones tan interesantes que basta anunciarlas para reconocer su trascendencia. En el deseo de contribuír modestamente al desarrollo de tal programa, he recogido los apuntes cuya exposición forma el presente trabajo.

  4. Dengue and Severe Dengue

    Science.gov (United States)

    ... all regions of WHO in recent years. Dengue virus is transmitted by female mosquitoes mainly of the species Aedes aegypti and, to a lesser extent, Ae. albopictus . This mosquito also transmits chikungunya, yellow fever and Zika infection. Dengue is widespread throughout the tropics, with ...

  5. Knowledge and attitudes in Puerto Rico concerning dengue prevention Conocimientos y actitudes en Puerto Rico en torno a la prevención del dengue

    Directory of Open Access Journals (Sweden)

    Carmen L. Pérez-Guerra

    2005-04-01

    prevención de la enfermedad. Realizamos la presente investigación con el fin de entender los conocimientos, actitudes y prácticas de la comunidad en torno a la prevención del dengue y de recoger sus ideas acerca de futuras campañas de prevención. MÉTODOS: Entre febrero y mayo de 2001 se llevó a cabo un estudio cualitativo basado en el método inductivo conocido por "categorización mediante teoría generada" [grounded theory analysis]. El estudio se efectuó con 34 participantes de cuatro entrevistas en grupo, todos ellos identificados mediante el sistema de vigilancia del dengue de Puerto Rico. RESULTADOS: En términos generales, los participantes tenían conocimientos adecuados acerca de la prevención del dengue, pero no asociaban los mosquitos que había dentro de las viviendas con Aedes aegypti. Repetían con insistencia que "el vecino" tenía que controlar los hábitat larvarios, y también le pidieron al Gobierno que fumigara. CONCLUSIONES: Los conocimientos y opiniones que afloraron en las discusiones mostraron ciertos patrones. Colocados a lo largo de un eje, estos revelaron un espectro desde muchos hasta muy pocos conocimientos que fuesen acertados acerca del dengue, la fiebre hemorrágica del dengue y las prácticas que deben observarse en conexión con estas afecciones. Hubo pocos participantes en un extremo u otro del espectro. Tres temas explicaron los patrones observados: ideas equivocadas en torno al dengue (basadas en información impartida anteriormente, la "invisibilidad" del dengue (por comparación con otras enfermedades, y la responsabilidad (individual y del Gobierno. Se recomendaron cuatro estrategias encaminadas a fomentar conductas de tipo preventivo: crear grupos comunitarios que identificaran las prioridades de la comunidad en materia de prevención; formar grupos de voluntarios que impartieran mensajes con fines preventivos; hacer visitas domiciliarias para demostrar ciertas medidas de control, y llevar a cabo una campaña de publicidad

  6. Manifestaciones clínicas del dengue hemorrágico en Puerto Rico, 1990-1991

    Directory of Open Access Journals (Sweden)

    José G. Rigau-Pérez

    1997-06-01

    Full Text Available Este estudio se realizó con el fin de mostrar que el dengue hemorrágico (DH se da en Puerto Rico, si bien es una enfermedad subnotificada, lo que se debe en parte a su subdiagnóstico en los hospitales. La vigilancia de casos graves de dengue permitió determinar que hubo 986 hospitalizaciones por sospecha de dengue en el período de 1990-1991. En esa época, el sistema de vigilancia identificó 20 casos de DH, incluidos tres de síndrome de choque por dengue (SCD. Nuestra subsecuente revisión de los expedientes de los 986 pacientes reveló que en 102 de ellos había razones para apoyar el diagnóstico clínico de DH (88 y de SCD (14. Entre estos 102 había 57 que dieron resultados virológicos o serológicos positivos a dengue y que reunían los criterios de caso de dengue establecidos por la OMS (fiebre, manifestaciones hemorrágicas, trombocitopenia y excesiva permeabilidad capilar. En el grupo de 57 pacientes, la media de edad era de 38 años y preponderaban los hombres (34, o sea 59,3%, incluidos ocho casos de SCD y dos (3,5% defunciones (en mujeres de 16 y 55 años de edad. Los síntomas hemorrágicos fueron leves y con frecuencia se observaron hemoconcentración, hipoalbuminemia y concentraciones elevadas de aspartato y alanina aminotransferasas. Las hospitalizaciones duraron unos 5 días en término medio. La descripción clínica de estos casos de DH en Puerto Rico coincide con descripciones anteriores de la enfermedad en la literatura médica, pero la distribución por edad de los pacientes es similar al patrón que se suele encontrar en las Américas (donde afecta a todos los grupos de edad, en contraste con el de Asia Sudoriental (donde afecta principalmente a niños pequeños. El número de casos identificados en nuestro estudio fue casi tres veces mayor que el número notificado por el sistema de vigilancia establecido. Nuestros resultados indican que es necesario mejorar la capacidad de los clínicos locales para reconocer y

  7. La eficacia de la vacunación en la prevención de la fiebre amarilla en Colombia

    Directory of Open Access Journals (Sweden)

    John C. Bugher

    1944-11-01

    Full Text Available La introducción de la vacuna contra la fiebre amarilla trajo como consecuencia la eliminación de las infecciones con el mismo virus, ocurridas en el laboratorio entre el personal de la División Sanitaria Internacional de la Fundación Rockefeller. Además, en Colombia no ha ocurrido ningún caso de infección entre los empleados de la Sección de Estudios Especiales, a pesar del contacto íntimo que mantienen con el virus, tanto en el laboratorio como en el campo.

  8. La eficacia de la vacunación en la prevención de la fiebre amarilla en colombia

    OpenAIRE

    Bugher, John C.; Gast-Galvis, Augusto

    2011-01-01

    La introducción de la vacuna contra la fiebre amarilla trajo como consecuencia la eliminación de las infecciones con el mismo virus, ocurridas en el laboratorio entre el personal de la División Sanitaria Internacional de la Fundación Rockefeller. Además, en Colombia no ha ocurrido ningún caso de infección entre los empleados de la Sección de Estudios Especiales, a pesar del contacto íntimo que mantienen con el virus, tanto en el laboratorio como en el campo.

  9. Scanning electron microscopy of the four larval instars of the Dengue fever vector Aedes aegypti (Diptera: Culicidae

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    Stefan Schaper

    2006-09-01

    Full Text Available Aedes aegypti is the main insect vector of Dengue fever and dengue hemorrhagic fever/dengue shock syndrome and represents the only vulnerable element in the control of this disease. Therefore, the identification and quantification of this mosquito is an important task; however, the majority of taxonomic keys are based on the 4th larval instar. For that reason, this study describes the four larval instars of A. aegypti using scanning electron microscopy. Morphological changes during larval development were observed at the pecten, comb scales and the ventral brush of the abdominal segment X; however, the 3rd and 4th instars showed similar structures with only a slight variation. The structures described in this study will be helpful in the identification of the four instars of A. aegypti, a fundamental task for comprehending the natural history of dengue mainly in new territories affected. Rev. Biol. Trop. 54 (3: 847-852. Epub 2006 Sept. 29.Aedes aegypti es el principal insecto vector de la fiebre del dengue y del dengue hemorrágico/síndrome del choque por dengue y es el único elemento atacable para el control de esta virosis. La identificación y cuantificación de éste es una tarea importante; no obstante, la mayoría de las llaves taxonómicas se basan en el cuarto estadio larval. Por esta razón, en este trabajo se describen los cuatro estadios larvales de A. aegypti los cuales fueron examinados mediante microscopia electrónica de rastreo. Los cambios morfológicos ocurridos durante el desarrollo larval fueron observados en el pecten, las escamas del peine, el cepillo ventral del décimo segmento. El 3ero y 4to estadios larvales mostraron estructuras similares con sólo ligeras variaciones. Las estructuras descritas en este artículo permiten identificar cualquiera de los cuatro estadios larvales de A. aegypti, lo cual representa una tarea importante en la comprensión de la historia natural del dengue en los nuevos territorios afectados.

  10. Fiebres hemorrágicas por Arenavirus en Latinoamérica

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    Ella Soto

    2010-01-01

    Full Text Available Las fiebres hemorrágicas virales producidas por Arenavirus incluyen a los virus endémicos en África (Lassa y el virus de la coriomeningitis linfocítica (LCMV, de distribución mundial, y los Arenavirus del Nuevo Mundo o Complejo Tacaribe, que incluye a los virus endémicos en las Américas (Junín, Machupo, Guanarito, Sabiá, Pichinde, entre otros. Los huéspedes naturales son los roedores y la infección en humanos se produce por el contacto con la orina y excretas. Las manifestaciones clínicas inicialmente son indistinguibles de otras fiebres hemorrágicas producidas por bacterias, parásitos y otros virus, constituyéndose esto en un problema de salud pública, por lo que se requiere realizar el diagnóstico diferencial utilizando técnicas serológicas y moleculares.

  11. Detección molecular del virus de la fiebre amarilla en muestras de suero de casos fatales humanos y en cerebros de ratón.

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    Jairo A. Méndez

    2003-06-01

    Full Text Available Hemos adaptado un método molecular basado en la técnica de transcripción reversa seguida de la reacción en cadena de la polimerasa (RT-PCR para diagnóstico alternativo de la infección por el virus de la fiebre amarilla. Se tomaron tres sueros liofilizados de casos fatales de fiebre amarilla y cuatro sueros frescos, de los cuales tres pertenecían a casos fatales de la enfermedad y el cuarto a un paciente sintomático con serología IgM positiva para fiebre amarilla; los sueros fueron tratados con Trizol-LS® para extraer el ARN viral que fue sometido a reacción de RT y posteriormente a PCR, para la cual se diseñaron dos parejas de iniciadores específicos de fiebre amarilla: iniciadores directos (sentido JM2104 (5´-CGTTGGGAGAGGAGATTC-3´ y JM2249 (5´-TTCTTCACTTCGGTTGGG-3´, e iniciadores inversos (antisentido JM2673 (5´- TCATCTGCCCTGCTTCTC-3´ y JM2751 (5´-CCTCTCTGGTAAACATTCT-3´. La aplicación de la técnica en tejidos se hizo en cerebros de ratón infectados con el virus amarílico, tratados con una solución de lisis antes de purificar el ARN. En geles de agarosa se observaron bandas únicas de amplificación del tamaño esperado (569 pb y 502 pb; todas las muestras fueron corroboradas con las dos parejas de iniciadores y en dos de las muestras de suero fresco los resultados positivos para fiebre amarilla fueron comprobados con estudio histopatológico. Este método de detección molecular permitió demostrar de manera rápida y eficiente la presencia del virus de la fiebre amarilla, hecho que tiene importantes implicaciones diagnósticas para este problema de salud pública.

  12. Determinación mediante inmunohistoquímica de infección por virus de la fiebre amarilla y virus de la hepatitis b

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    Cecilia Morón C

    2003-03-01

    Full Text Available La inmunohistoquímica (IHQ constituye una herramienta para definir la etiología en el síndrome icterohemorrágico. Objetivo: Identificar mediante IHQ la presencia en hígado del antígeno de superficie de la hepatitis B y del virus de la fiebre amarilla. Materiales y métodos: Se incluyeron muestras de tejido hepático procedentes de 55 fallecidos por síndrome icterohemorrágico, remitidos entre enero de 2000 y diciembre de 2001 al Instituto Nacional de Salud, (Lima, Perú. Resultados: La prueba se realizó únicamente en 46 muestras, 33% (15/46 fueron diagnosticados por histopatología como fiebre amarilla, de ellos, 9 casos fueron positivos por IHQ para fiebre amarilla, siendo 2 de ellos también positivos para HBsAg. Histológicamente, se reportaron 6 casos como hepatitis con necrosis submasiva o masiva, que por IHQ fueron sólo 2 casos positivos para fiebre amarilla. En 39% (18/46 no se llegó al diagnóstico etiológico de la hepatitis, y finalmente hubo 2 casos con diagnóstico histopatológico de ádenocarcinoma hepático y sólo se obtuvo positividad por IHQ para HBsAg en uno. Conclusión: La IHQ es una alternativa para la confirmación diagnóstica de hepatitis B y fiebre amarilla.

  13. Enfoque de riesgo en la prevención del dengue Risk approach in dengue prevention

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    Oneida Terazón Miclín

    2012-09-01

    Full Text Available El dengue es una enfermedad transmitida por los mosquitos Aedes aegypti y Aedes albopictus. Tiene un cuadro clínico variado, donde la fiebre es el signo fundamental, así como formas graves de presentación; está asociada, además, con la presencia de macrofactores y microfactores. Al aplicar el enfoque de riesgo en las comunidades donde se reproduce el vector, con sus 6 componentes: factor de riesgo (existencia de tanques desprotegidos y depósitos artificiales, marcador de riesgo (índices de focos de mosquitos superiores a los permisibles, indicador de riesgo (aparición de casos febriles en estas áreas, signo de riesgo (presencia de dolores óseos en la población febril, grupo de riesgo (la población que vive en manzanas reiterativas de focos y factor de protección (autofocal familiar, podrían trazarse estrategias intersectoriales que evitarían la aparición de esta afección. A tales efectos se realizó una revisión bibliográfica para completar así la información disponible en las bases de datos nacionales al respecto.Dengue is a disease transmitted by the mosquitos Aedes aegypti and Aedes albopictus. It has a varied clinical pattern, in which fever is the fundamental sign, as well as severe forms of presentation; it is also associated with the presence of macrofactors and microfactors. When applying the risk approach in the communities where the vector reproduces, with its 6 components: risk factor (existence of uncovered and artificial deposits, risk marker (numbers of mosquitos focus over the permissible ones, indicator of risk (appearance of feverish cases in these areas, risk sign (ocurrence of bony pains in the feverish population, risk group (the population living in iterative blocks with focus and protection factor (focus family detection, intersector strategies could be devised, which would avoid the emergence of this disease. To such effects a literature review was carried out, so as to complete the available

  14. La distribución estacional de fiebre amarilla humana y del mosquito haemagogus en la Intendencia del Meta (Colombia

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    Augusto Gast Galvis

    1945-08-01

    Full Text Available Las zonas de las estribaciones de la cordillera en la Intendencia del Meta han sido por muchos años de gran interés desde el punto de vista de fiebre amarilla selvática. Las condiciones generales de estas zonas en relación con la endemicidad de esta enfermedad han sido descritas por Boshell (1938 y el pormenorizado trabajo de campo llevado a cabo por Bugher y sus colaboradores (1944 incriminó al Haemagogus capricornii como el principal vector en esa región.

  15. Dengue fever

    African Journals Online (AJOL)

    symptoms and research has been limited to studies ... severity and problems with vaccination (4). History of ... Americas in 1970s reduced the spread of dengue fever. After this .... Reiter P. Yellow fever and dengue: a threat to Europe? 9.

  16. Informe sobre la fiebre amarilla silvestre en la región del Meta, desde julio 1934 hasta diciembre de 1936

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    Jorge Boshell Manrique

    1938-02-01

    Full Text Available En agosto de 1934 el Padre Francisco Savary, misionero de la Compañía Montfort, da la voz de alarma acerca de unos casos de fiebres que se han presentado en unas veredas del vecindario de Restrepo y cuyo cuadro clínico corresponde al descrito en el capítulo de fiebre amarilla de su Manual de Misionero. Se practica una primera investigación encontrando, en efecto, manifestaciones mórbidas que sugieren fiebre amarilla. El brote presenta una característica extraña que confunde a primera vista la investigación, en un momento en que la noción de la fiebre silvestre, o sea sin Aedes aegypti, no está aún generalizada. No se encuentra tal zancudo en la región. A consecuencia de un informe de la Dirección Nacional de Higiene, el Dr. E. R. Rickard, médico de la Fundación Rockefeller, baja a Villavicencio y me deja instrucciones precisas, con elementos de investigación. En esta época el autor era Director Intendencial de Higiene. Se toman 30 muestras de sangre distribuídas entre personas convalecientes de ataques de la enfermedad, entre personas que moraban en las casas en que habían ocurrido casos y entre compañeros de trabajo de personas atacadas. De las muestras sometidas a la prueba de inmunidad para fiebre amarilla, 20 resultaron positivas, 2 inconclusivas y 8 negativas. Estos resultados traen por consecuencia el establecimiento de una comisión de investigación epidemiológica en la región de Restrepo.

  17. Lo que usted debe saber acerca del dengue

    OpenAIRE

    Vélez, Juan David; Fundación Valle de Lili; Salazar, Juan Carlos; Rosso Suárez, Fernando

    1998-01-01

    Epidemiología del dengue/Transmisión/Presentación clínica/Síntomas en niños/Diagnostico de laboratorio/Dengue clásico/Dengue hemorrágico/Dengue hemorrágico con choque/ ¿Qué es dengue hemorrágico?/ ¿Cuál es la diferencia entre dengue hemorrágico y dengue clásico?/ ¿Qué son las plaquetas?/ ¿Qué puedo hacer para prevenir el dengue?/ ¿Cuándo debo consultar?/ ¿Cuándo se debe hacer un hemograma?/ ¿Cuándo se debe hospitalizar un paciente con dengue?

  18. Frecuencia de infección del tracto urinario en lactantes con fiebre, sin foco infeccioso evidente, que consultan a la Unidad Vida Infantil de la Universidad de Antioquia del Hospital Francisco Valderrama, Turbo (Antioquia Frequency of urinary tract infections in febrile infants without evidence of an infectious source. from the clinic of the Unidad Vida Infantil of the University of Antioquia, Hospital Francisco Valderrama, Turbo, Colombia.

    Directory of Open Access Journals (Sweden)

    Harold Durango Galván

    2006-01-01

    Full Text Available NTRODUCCIÓN: se ha documentado que en los niños las infecciones del tracto urinario son una causa frecuente de fiebre sin causa aparente. De acuerdo con los resultados de algunas investigaciones, la prevalencia está entre 4 y 13%. Las infecciones urinarias en los niños, en especial en los menores de dos años, se asocian con mayor incidencia de reflujo vesicoureteral y compromiso de parénquima renal. Por lo anterior, los niños con infección urinaria requieren especial atención con el fin de prevenir cicatrices renales, hipertensión arterial e insuficiencia renal crónica. OBJETIVO: establecer la frecuencia de infección urinaria en lactantes febriles menores de dos años de edad atendidos en la Unidad Vida Infantil de la Universidad de Antioquia y en el Hospital Francisco Valderrama de Turbo Antioquia, entre el 1º de febrero de 2003 y el 31 de enero de 2004. MÉTODOS: se incluyeron cincuenta niños menores de 24 meses de edad con fiebre sin causa aparente, entendiéndose como tal una enfermedad febril aguda en la que no se encuentra la causa luego de anamnesis y examen físico cuidadosos. Se realizaron los siguientes exámenes de laboratorio: leucograma, sedimentación, tirilla en orina para detectar estearasa leucocitaria y nitritos, uroanálisis (UA (leucocitos en orina por mm3, tinción de gram de una gota de orina sin centrifugar, uroanálisis microscópico (leucocitos y bacterias por campo de alto poder y urocultivo cuantitativo (se consideró positivo cuando se encontraron más de 10.000 unidades formadoras de colonias, UFC, por ml. Todas las muestras de orina se obtuvieron por sonda vesical. Para cada una de las pruebas se determinó la sensibilidad, la especificidad y el valor predictivo positivo y negativo. RESULTADOS: la frecuencia de infección urinaria (crecimiento de más de 10.000 UFC de un patógeno urinario por ml fue 10%. La edad promedio fue siete meses. La mayoría de los niños con infección urinaria ten

  19. De miasmas a mosquitos: el pensamiento médico sobre la fiebre amarilla en Yucatán, 1890-1920

    OpenAIRE

    Alcalá Ferráez,Carlos

    2012-01-01

    La fiebre amarilla fue un problema de salud pública desde la época colonial debido a la frecuencia con que se presentaba en forma epidémica y a su alta letalidad. El objetivo de este trabajo es analizar el pensamiento médico y su evolución con respecto al vómito prieto entre 1890 y 1921 en Yucatán. Dos aspectos serán abordados: algunos antecedentes con respecto a la enfermedad y las ideas predominantes hasta 1881; y la propuesta de Carlos Finlay para vencer el escepticismo ante su teoría por ...

  20. La fiebre amarilla y su control.

    Directory of Open Access Journals (Sweden)

    Martha Patricia Velandia

    2004-03-01

    Full Text Available la candidiosis crónica diseminada. El tercer patrón (imágenes hipoecoicas, aunque no es específico de la candidiosis crónica diseminada, es el más comúnmente hallado en ambas técnicas. En la paciente se observaron los patrones 2 y 3, y el diagnóstico se confirmó con el estudio histopatológico.

  1. Los vecinos de Buenos Aires ante las epidemias de cólera y fiebre amarilla (1856-1886

    Directory of Open Access Journals (Sweden)

    Maximiliano Ricardo Fiquepron

    2017-01-01

    Full Text Available El artículo analiza un tipo particular de institución surgida para combatir en las epidemias de cólera de 1867, 1868 y 1873, y en las de fiebre amarilla, ocurridas en 1871 y 1886. Las comisiones de vecinos han sido interpretadas mayormente por la historiografía como una respuesta de la sociedad frente a la parálisis del Estado, sobre todo en su dimensión municipal. Este artículo revisa esta afirmación y argumenta que las epidemias generaron la posibilidad de crear, reformar y convertiráreas específicas del Estado municipal, sobre todo aquellas vinculadas con la salud e higiene. Hemos denominado a este proceso vector de institucionalización, dado que con las epidemias de cólera y de fiebre amarilla aparecieron –en principio, transitoriamente– una serie de medidas y formas de organización que luego fueron institucionalizadas. Además, sostenemos que la indudable relevancia de la fiebre amarilla de 1871 no debe obstruir el estudio de otras epidemias, en la medida en que estas fueron también muy significativas en el proceso de gestación de las comisiones de vecinos y, más importante, contribuyeron al fortalecimiento institucional de la municipalidad. Esta mirada permite mostrar espacios de interacción, subordinación, independencia y/o enfrentamiento producidos entre las comisiones de vecinos y el Estado municipal y provincial de la provincia de Buenos Aires.

  2. Fiebre amarilla en Africa: su impacto en salud pública y perspectivas para su control en el siglo XXI

    Directory of Open Access Journals (Sweden)

    Oyewale Tomori

    2002-06-01

    Full Text Available Durante las últimos dos décadas, la fiebre amarilla ha vuelto a emerger con fuerza hasta constituirse en un grave problema de salud pública en Africa, trayendo indecibles sufrimientos a mucha de su población y convirtiéndose en un obstáculo más para su desarrollo social y económico. A pesar de los destacados logros alcanzados en el conocimiento de la epidemiología de esta enfermedad y de la disponibilidad de una vacuna segura y eficaz, la fiebre amarilla continúa siendo un serio problema de salud pública tanto en Africa como en América en donde anualmente afecta a 200.000 personas, aproximadamente, y causa alrededor de 30.000 muertes. Africa contribuye con más del 90% de la morbilidad y mortalidad por fiebre amarilla en el planeta. Además de la severidad de la morbilidad y la mortalidad, que muestran un acusado subregistro, los sucesivos brotes y las medidas de control han traumatizado la prestación de los servicios de salud disponibles, sobrecargando los ya exiguos recursos internos, abusando de las donaciones y llevando a un lamentable desperdicio de vacunas. Las epidemias recientes en Africa han afectado predominantemente a los niños menores de 15 años. La fiebre amarilla es una enfermedad de fácil control, lo cual puede ilustrarse con dos situaciones ocurridas en Africa. Entre 1939 y 1952, la enfermedad virtualmente desapareció en varias zonas del continente en las que se adelantaron programas de vacunación masiva de manera regular. Más recientemente, después de la epidemia de 1978-1979 en Gambia, se llevó a cabo una campaña masiva de vacunación contra la fiebre amarilla, logrando un cubrimiento de 97% de la población mayor de seis meses de edad, a partir de la cual la vacuna se incorporó permanentemente al programa de inmunización. Desde entonces, Gambia ha mantenido cubrimientos de más del 80%, sin notificación de nuevos casos, a pesar de tener frontera con Senegal que padeció brotes en 1995 y 1996. La

  3. Enfoque desde la ciencia post-normal de la epizootia fiebre aftosa

    Directory of Open Access Journals (Sweden)

    Schütz Gabriel Eduardo

    2003-01-01

    Full Text Available Este trabajo pretende analizar la epizootia de fiebre aftosa del invierno británico de 2001 desde el enfoque de la ciencia post-normal. Serán analizadas las participaciones de los diferentes actores sociales y las interacciones de las categorías: confianza, gobernanza, incertidumbre, valores e intereses. Todos estos factores formaron parte de una crisis que, por un lado, conjugó los intereses políticos de un gobierno en campaña electoral junto con los intereses económicos de un estado miembro de la Unión Europea y por el otro, los intereses de la población afectada junto con todos aquellos problemas relacionados con la salud y el medio ambiente. Las medidas tomadas para detener esta enfermedad 'económica' se transformaron en un verdadero experimento heterogéneo a gran escala social, un fenómeno típico de la modernidad que exige nuevas formas de abordar la ciencia y los procesos decisorios.

  4. Actividad larvicida de la toronja, Citrus paradisi (Rutaceae sobre dos vectores del dengue

    Directory of Open Access Journals (Sweden)

    Jorge Morales-Saldaña

    2013-04-01

    Full Text Available La actividad larvicida del aceite esencial de la toronja (Citrus paradisi fue evaluada contra los mosquitos Aedes aegypti y Aedes albopictus, los cuales representan vectores potenciales de la fiebre del dengue. La CL50 del aceite esencial de la toronja fue de 47,3 ppm y 85,1 ppm para Ae. aegypti y Ae. albopictus, respectivamente. El análisis del aceite por GC-MS, mostró químicos conocidos como insecticidas los cuales podría explicar la acción tóxica sobre las larvas de los mosquitos evaluados. Esta actividad tóxica sobre Ae. aegypti fue mayor en comparación con otros aceites cítricos, lo que sugiere mayores instigaciones en esta línea y de esta manera poder recomendarlo como regulador de mosquitos a las diferentes campañas contra el Ae. aeygpti. En la literatura revisada no encontramos ninguna investigación donde haya sido evaluado aceites esenciales de cítricos contra larvas del mosquito Ae. albopictus.

  5. «Epidemia»: Un repaso a la fiebre hemorrágica por Ébola

    Directory of Open Access Journals (Sweden)

    José Francisco CAMACHO AGUILERA

    2016-04-01

    Full Text Available A través de la película Outbreak (1995 de Wolfgang Peterson, se repasan en este artículo a la fiebre hemorrágica por Ébola, dado su gran parecido con la enfermedad ficticia creada en esta película producida por el virus Motaba. Se presenta una revisión de la historia, las características del virus, transmisión del virus, las manifestaciones clínicas, el diagnóstico, la mortalidad, el tratamiento y la prevención, contrastándose con lo presentado en la película. Finalmente, se muestran los niveles de bioseguridad para el manejo de los agentes infecciosos

  6. Observaciones en el Ornithodoros Forcosus sobre su posible rol como vector de la Fiebre Recurrente

    Directory of Open Access Journals (Sweden)

    Arístides Herrer

    1957-12-01

    Full Text Available Tratando de verificar la posible infección por borrelias en el Ornithodoros Forcosus Neumann, 1908, se realizaron observaciones experimentales en las que se utilizó un total de 1,655 especímenes de esta garrapata. En tales estudios se emplearon pericotes blancos y cobayos. Con triturado de garrapatas fueron inoculados 68 animales (64 pericotes y 4 cobayos y 37 (16 pericotes y 21 cobayos fueron empleados para alimentar sobre ellos varios lotes de garrapatas. Los resultados de todas estas observaciones fueron negativas. Las garrapatas con las que se han efectuado estos estudios procedían de las localidades de Limabamba, Mariscal Benavides, Camporredondo, Ocalli y Luya, todas en el departamento de Amazonas, y a altitudes que varían entre 1,400 y 2,300 metros sobre el nivel del mar. Desde que la fiebre recurrente parece ser endémica en el Perú, especialmente en localidades de considerable altitud, es de suponer que en este país sea trasmitida principalmente por piojos.

  7. Fiebre Tifoidea Diagnóstico por pruebas inmunoenzimáticas: Elisa

    Directory of Open Access Journals (Sweden)

    Miguel Guzmán

    1981-06-01

    Full Text Available Este trabajo describe el desarrollo y normalización de una técnica inmunoenzimática para el diagnóstico indirecto de la Fiebre Tifoidea. El método permite un análisis simple y objetivo de los resultados. La reacción enzimática es proporcional a la concentración de anticuerpos en el suero contra el antígeno somático-0, por tanto, el método es cuantitativo. Por lo demás, la técnica tiene un alto grado de especificidad para Salmonella typhi, ya que los sueros de pacientes con Salmonelosis causada por Salmonella enteritidis serotipos paratyphi A, B y typhimurium dieron resultados negativos, en forma similar a los presentados por el grupo control antes de la vacunación específica. Los resultados obtenidos con esta técnica permitieron definir el nivel de anticuerpos que puede presentar una población control supuestamente sana frente a los niveles inducidos por la enfermedad. Los resultados postvacunales en el grupo control mostraron títulos sorprendentemente bajos; un análisis de este fenómeno se presentó en forma amplia. Igualmente se proponen futuras investigaciones sobre este campo.

  8. Dengue retinochoroiditis.

    Science.gov (United States)

    Tabbara, Khalid

    2012-01-01

    Dengue is a mosquito-borne infection caused by a flavivirus. I describe the ocular findings observed in two patients infected with dengue virus who presented with acute onset of loss of vision preceded by febrile illness, malaise, generalized fatigue headache, and maculopapular rash. Ophthalmologic evaluation in each patient revealed a normal anterior segment. Vitreous cells were noted in one patient. Ophthalmoscopy revealed multiple foci of retinochoroiditis, vasculitis, cotton-wool spots, and retinal hemorrhages. The healing of the lesion showed discrete atrophic and pigmented retinochoroiditic scars. Fluorescein angiography displayed early hypofluorescence and late hyperfluorescence suggestive of leakage. The healed scars showed late staining. The serologic testing showed elevated IgG antibodies, and one had high IgM antibodies to dengue virus. Ocular findings of dengue fever consist of multifocal areas of retinochoroiditis and may lead to loss of vision. In Saudi Arabia, dengue fever should be considered in the differential diagnosis of multifocal chorioretinal lesions and retinal vasculitis.

  9. Modelos animales de fiebres hemorrágicas humanas producidas por arenavirus

    Directory of Open Access Journals (Sweden)

    Juan D. Rodas

    2004-03-01

    Full Text Available

    En ciertas áreas endémicas para el virus de la fiebre de Lassa en África, este agente representa una amenaza importante para la salud pública. El agente etiológico de la fiebre de Lassa es transmitido de ratas a humanos a través de la sangre o de la exposición de las mucosas a aerosoles y causa cerca de 300.000 casos cada año. El virus de la coriomeningitis linfocítica (LCMV, estrechamente relacionado con el virus de la fiebre de Lassa, produce variados resultados después de su inoculación en primates. En nuestro laboratorio hemos empleado la especie Macaca mulata de mono Rhesus como modelo de fiebre de Lassa en el hombre, usando una variante patogénica (WE y una no patogénica (Armstrong de LCMV.

    Nuestros objetivos fueron determinar el resultado de la infección en monos después de la exposición oral y el desafío letal posterior, caracterizar la respuesta inmune protectora y probar protección cruzada usando las dos cepas virales mencionadas.

    El experimento inicial utilizando las vías de inoculación intravenosa (experimental clásica y oral (hipotética permitieron describir cómo, la vía oral. Produce una “aparente” infección asintomática, mientras la intravenosa es uniformemente letal; permitiendo concluir por lo tanto, que la ruta de exposición influencia dramáticamente el resultado clínico de la infección.

    En un segundo experimento, dos dosis altas (107 o 108 unidades formadoras de placa de la cepa WE del virus LCMV fueron

  10. La Re-emergencia de la fiebre amarilla en Colombia, 2003

    OpenAIRE

    Velandia, Martha Patricia

    2004-01-01

    Antecedentes históricos de la introducción del virus a Colombia. La fiebre amarilla es una enfermedad febril hemorrágica transmitida por mosquitos infectados. Existen tres tipos de transmisión la fiebre amarilla la selvática, la intermedia y la urbana. La fiebre amarilla se presenta únicamente en África y en América, a pesar de la existencia vectores en otros continentes como Asia. Los tras ciclos se presentan en África pero en Sur América solo se presentan la selváti...

  11. La infección con el virus del dengue induce apoptosis en células del neuroblastoma humano SH-SY5Y

    Directory of Open Access Journals (Sweden)

    Jaime E. Castellanos

    2016-08-01

    Conclusión. Estos resultados sugieren, en su conjunto, que la regulación positiva del TNF-α podría hacer parte del proceso que induce daño y muerte celular durante el desarrollo de la encefalitis por dengue.

  12. Estrategia intersectorial y participativa con enfoque de ecosalud para la prevención de la transmisión de dengue en el nivel local An inter-sector participatory strategy in Cuba using an ecosystem approach to prevent dengue transmission at the local level

    Directory of Open Access Journals (Sweden)

    Cristina Díaz

    2009-01-01

    Full Text Available Cuba está ubicada en una zona de países con alta incidencia de dengue. En los últimos 10 años ha sido afectada por varias epidemias, es por ello que se diseñó, implementó y evaluó una estrategia participativa, basada en el enfoque de ecosalud, la cual estuvo dirigida a propiciar acciones intersectoriales en la gestión del ecosistema para disminuir las poblaciones del mosquito Aedes aegypti y prevenir la transmisión de dengue en el municipio Cotorro de Ciudad de La Habana, Cuba. Para el desarrollo de este trabajo se utilizó la metodología de investigación acción participativa. Como resultado del proceso se pudo describir una estrategia que garantiza la participación activa de la comunidad, los sectores y el gobierno en la producción de ecosistemas saludables, se desarrollaron acciones de prevención y control oportunas e integrados que disminuyeron los riesgos para la proliferación del vector y la transmisión local de la enfermedad. Este enfoque permitió el análisis holístico de los problemas, su priorización y la gestión de sus soluciones; la estrategia se sostiene dos años después de concluido el proceso.Cuba is located among a group of countries with high dengue incidence. Following several epidemics in the last 10 years, the country designed, implemented, and evaluated a participatory strategy based on the Ecohealth approach. The aim was to promote inter-sector ecosystem management to decrease Aedes aegypti infestation and prevent dengue transmission in the municipality of Cotorro, in Havana city. The study adopted a participatory research methodology. The strategy ensured active participation by the community, diverse sectors, and government in the production of healthy ecosystems. Timely and integrated measures for prevention and control were developed, thereby decreasing the risk of vector proliferation and local dengue transmission. The approach allowed holistic problem analysis, priority setting, and

  13. Dengue Returns

    Centers for Disease Control (CDC) Podcasts

    2016-08-25

    Dr. Tyler Sharp, a CDC epidemiologist, discusses dengue in southern Texas.  Created: 8/25/2016 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 8/25/2016.

  14. Fiebre prolongada: Una visión contemporánea de un viejo problema clínico de difícil diagnóstico

    OpenAIRE

    Madera, CD; García, SM; Monsalve, P; Simonovis, N

    2000-01-01

    El objetivo de este estudio es determinar las causas mas frecuentes de Síndrome Febril Prolongado (SFP) en el HUC y diseñar estrategias de aproximación diagnóstica al paciente con SFP en nuestro medio. Se presenta un estudio prospectivo realizado en los servicios de Medicina Interna y Enfermedades Infecciosas del Adulto de HUC, entre Diciembre de 1993 y Diciembre de 1995, obteniéndose 100 pacientes que cumplieron los siguientes criterios de inclusión: 1)Edad > 12 años; 2) Fiebre > 38,3ºC y 3)...

  15. Vaccines against dengue: a review of current candidate vaccines at advanced development stages Vacunas contra el dengue: una revisión de las vacunas candidatas en etapas avanzadas de desarrollo

    OpenAIRE

    Joachim Hombach

    2007-01-01

    Los esfuerzos sistemáticos para desarrollar una vacuna contra el dengue comenzaron durante la Segunda Guerra Mundial, inspirados en el desarrollo exitoso de una vacuna contra la fiebre amarilla. Sin embargo, la falta de modelos adecuados de la enfermedad, la información incompleta acerca de los mecanismos patogénicos y los insuficientes incentivos económicos han dificultado los avances. Debido al impacto actual del dengue en todo el mundo y su explosiva diseminación, ha aumentado el interés e...

  16. De miasmas a mosquitos: el pensamiento médico sobre la fiebre amarilla en Yucatán, 1890-1920 From miasmas to mosquitoes: medical thought on yellow fever in Yucatan, 1890-1920

    OpenAIRE

    Carlos Alcalá Ferráez

    2012-01-01

    La fiebre amarilla fue un problema de salud pública desde la época colonial debido a la frecuencia con que se presentaba en forma epidémica y a su alta letalidad. El objetivo de este trabajo es analizar el pensamiento médico y su evolución con respecto al vómito prieto entre 1890 y 1921 en Yucatán. Dos aspectos serán abordados: algunos antecedentes con respecto a la enfermedad y las ideas predominantes hasta 1881; y la propuesta de Carlos Finlay para vencer el escepticismo ante su teoría por ...

  17. Análisis genético del virus peruano de la fiebre amarilla

    Directory of Open Access Journals (Sweden)

    Carlos Yábar V

    2002-01-01

    Full Text Available Objetivo: Determinar las variantes genéticas de aislamientos del virus peruano de la Fiebre Amarilla (FA. Materiales y métodos: la región carboxiterminal del gen de la envoltura (E de cinco aislamientos de FA obtenidas de pacientes provenientes de Ayacucho 1978 (PER1, Junín 1995 (PER2, Cerro de Pasco (PER3, Cusco (1998 y San Martín (1999 fue amplificada por PCR, secuenciada y analizada con programas software de ADN. Resultados: el índice de similaridad de la secuencia de nucleótidos entre los cinco aislamientos reveló valores oscilantes entre 94,3% y 99,3%, mientras que la secuencia de aminoácidos presentó valores entre 97,6% y 99,7% de similaridad. El análisis filogenético demostró una distancia genética entre 0,40 y 6,50 mediante la secuencia de nucleótidos y a través de la secuencia de aminoácidos se observó un rango de 0,30 y 4,29. Sin embargo, las secuencias correspondientes a los sitios de glicosilación y a los epítopes de reconocimiento humoral fueron conservadas entre los cinco aislamientos, con excepción de algunos aislamientos de referencia reportados por otros autores. Conclusiones: los virus de FA peruanos forman un grupo filogenético distinto a otros virus de FA sudamericanos, basados en el análisis genéticos del gen E.

  18. Tendencias de la mortalidad por fiebre amarilla, Colombia, 1998-2009

    Directory of Open Access Journals (Sweden)

    Ángela María Segura

    2013-08-01

    Full Text Available Introducción. La fiebre amarilla es una enfermedad tropical desatendida, razón por la cual el conocer las tendencias de mortalidad por fiebre amarilla en Colombia, constituye una importante fuente de información para la toma de decisiones y las intervenciones en salud pública. Objetivo. Analizar las tendencias de mortalidad fiebre amarilla en Colombia (1998-2009 y las diferencias que presentan las fuentes de información de morbilidad y mortalidad en el país, que afectan indicadores como el de letalidad. Materiales y métodos. Es un estudio descriptivo de las muertes por fiebre amarilla, según el Departamento Administrativo Nacional de Estadística, y de la incidencia de la enfermedad, según el Instituto Nacional de Salud. Se usaron fuentes secundarias de información en el cálculo de proporciones de las características sociodemográficas de los fallecidos y las medidas epidemiológicas de letalidad, incidencia y mortalidad por fiebre amarilla, por departamento de residencia de los fallecidos. Resultados. Las muertes por fiebre amarilla se presentan principalmente en hombres, en edad de trabajar, residentes en zonas rurales dispersas, afiliados al régimen vinculado, residentes en las zonas oriental, suroriental, norte y central del país. Se observaron inconsistencias en los informes reportados que afectan el análisis comparativo. Conclusión. Los habitantes de los departamentos ubicados en los territorios nacionales y en Norte de Santander presentan mayor riesgo de enfermar y de morir por fiebre amarilla, pero esta información pudiera estar subestimada, según la fuente de información utilizada en su cálculo.   doi: http://dx.doi.org/10.7705/biomedica.v33i0.698

  19. Dengue viral infections

    OpenAIRE

    Malavige, G; Fernando, S; Fernando, D; Seneviratne, S

    2004-01-01

    Dengue viral infections are one of the most important mosquito borne diseases in the world. They may be asymptomatic or may give rise to undifferentiated fever, dengue fever, dengue haemorrhagic fever (DHF), or dengue shock syndrome. Annually, 100 million cases of dengue fever and half a million cases of DHF occur worldwide. Ninety percent of DHF subjects are children less than 15 years of age. At present, dengue is endemic in 112 countries in the world. No vaccine is available for preventing...

  20. Vigilancia epidemiológica del dengue en Antioquia

    Directory of Open Access Journals (Sweden)

    Marta Cecilia Ospina Ospina

    2004-03-01

    en el año 2002 en los municipios de Bello, Medellín, Cáceres, Valdivia, San Pedro de Urabá, Cisneros y Turbo, en coincidencia con un aumento en el número de casos. En los años 2002 y 2003 circularon los cuatro serotipos.

    REFERENCIAS

    1. JARAMILLO C, DE LOS RÍOS J. Dengue y Fiebre amarilla en Antioquia. Boletín Epidemiológico de Antioquia. 1979; 4 (5,6: 67-80

    2. ECHEVERRY ML. Dengue en Medellín. Boletín Epidemiológico de Antioquia. 1980; 5(3: 68-69

    3. DIRECCIÓN SECCIONAL DE SALUD DE ANTIOQUIA. Oficina de Epidemiología. Dengue. Boletín Epidemiológico de Antioquia. 1997; 22(3: 311-314.

    4. http://www.dssa.gov.co/vectores/vectores.htm. Julio 8 de 2004

    5. ARBELAEZ MP, ESCOBAR JP, LÓPEZ Y. Fiebre hemorrágica del Dengue en Antioquia 1990. Boletín Epidemiológico de Antioquia. 1990; 15 (1:111-120

    6. OSPINA MC, RAMÍREZ RE. Características clínicas epidemiológicas y de Laboratorio en la epidemia de Dengue en Antioquia 1997-1998. Revista Epidemiológica de Antioquia. 2001; 26 (3-4: 151-157.

    7. MONSALVE G, OSPINA MC, CASTRILLÓN J, ESCOBAR JP,  LÓPEZ Y. Circulación Viral de dengue confirmada por diagnóstico de laboratorio. Antioquia, 1995. Boletín de Vectores. 1996; 7(1: 10-14

  1. Detección, manejo y percepción materna de la fiebre en niños Cali-Colombia

    Directory of Open Access Journals (Sweden)

    Fabio Nelson Figueroa

    2012-01-01

    Conclusiones. El temor a la fiebre (“fiebre fobia” para algunos estuvo presente en la mayoría de madres. Se evidenciaron algunas conductas inapropiadas; como la preferencia del método palpatorio al uso del termómetro, el alto uso de terapias antipiréticas, el miedo a las convulsiones, la sobreestimación de temperaturas para fiebre grave y la creencia de que la fiebre en sí, es una enfermedad.

  2. La fiebre de Chikungunya en el período neonatal

    Directory of Open Access Journals (Sweden)

    Hernando Baquero-Latorre

    2015-01-01

    Full Text Available La fiebre de Chikungunya es una enfermedad tropical desatendida en muchos países por su relativa baja letalidad. Esta enfermedad es causada por el virus de Chikungunya (VCHIK, transmitido por artrópodos pertenecientes al género Alphavirus de la familia Togaviridae. Este virus se transmite a los humanos a través de la picadura de mosquitos Aedes infectados (Aedes aegypti, Aedes albopictus. Generalmente la enfermedad por VCHIK se manifiesta como una artritis autolimitada, ex-cepto en personas inmunocomprometidas y en recién nacidos, en los que se puede manifestar como una enfermedad grave.La trasmisión de infecciones de la madre al niño se puede dar in útero (congénita alre-dedor del periodo del parto (perinatal o de manera posnatal a través de la leche materna. La infección materna se disemina al embrión y al feto por infección ascendente desde la vagina, vía cuello uterino hasta llegar al líquido amniótico o vía hematógena secundaria a viremia, parasitemia o bacteremia.La vía hematógena de infección fetal es más común durante episodios de viremia materna como los que se presentan durante la infección por VCHIK. La transmisión perinatal del VCHIK es un evento poco frecuente que ocurre en los brotes masivos de infección cuando el riesgo de viremia en mujeres embarazadas cercanas al término se convierte en no despreciable. En estas pacientes, la infección neonatal se presenta con una probabilidad de ocurrencia del 50 %, y se expresa en el recién nacido principalmente como postración y encefalopatía.

  3. Estudio de un brote epidémico de fiebre amarilla selvática en el pie de monte de La Sierra Nevada de Santa Marta, 1979

    Directory of Open Access Journals (Sweden)

    Hernando Vidales

    1981-12-01

    Full Text Available En 1979 se observó en Colombia una epidemia de fiebre amarilla selvática, en las estribaciones más bajas de la Sierra Nevada de Santa Marta, donde nunca antes se había registrado la enfermedad. Los casos ocurrieron en las cercanías de las ciudades de Valledupar y Santa Marta, por entonces infestadas con Aedes aegypti .Veinte de ellos fueron confirmados por examen histopatológico de hígado o por aislamiento de virus y en otros 36 se hizo un diagnóstico de presunción, con base en estudios clínicos, epidemiológicos y serológicos. Entre los primeros hubo 14 defunciones y entre los segundos 13. En las localidades urbanas del Brea se llevaron a cabo intensas campañas de lucha contra el A. aegyptiy de vacunación. No se registraron casos urbanos de la enfermedad. Los enfermos se infectaron en bosques estrechos de galería y en cafetales. donde previa y paralelamente se observó mortalidad en monos í Alouatta seniculus. El reconocimiento entomológico mostró en la región la presencia de 3 especies de Haemagogus, entre ellas H. janthinomys Con 745 mosquitos se hicieron 192 mezclas para intentar aislamiento de virus, habiéndose obtenido sólo uno positivo para fiebre amarilla, a partir de H. janthinomys. La epidemia descrita es un ejemplo mBs de la invasión del virus amarílico a nuevos "habitats" rurales,  con la consiguiente amenaza para las ciudades vecinas infestadas con A. aegypti, el riesgo de la urbanización del virus, lo cual exige la adopción inmediata de medidas para abatir el mosquito y para vacunar a la población expuesta.

  4. Coinfección por dengue y leptospirosis en una niña de la amazonía peruana

    Directory of Open Access Journals (Sweden)

    Alexandra Núñez-Garbín

    Full Text Available Se reporta el caso de una niña de 10 años, natural y procedente de la ciudad de Iquitos en Perú que presentó cefalea, fiebre, escalofríos, dolor osteomuscular, leve dolor en epigastrio, epistaxis y hematemesis. Al examen físico la paciente se encontraba afebril y en regular estado general. Por medio de pruebas serológicas se confirmó la infección por dengue y leptospirosis. La paciente recibió hidratación endovenosa con cloruro de sodio al 0,9% y penicilina G sódica, logrando una evolución clínica favorable por lo que fue dada de alta a los pocos días de su ingreso al hospital. Aunque estas dos enfermedades son comunes en la Amazonía peruana, la presencia simultánea de ambas en la población pediátrica es poco documentada; por ello, una buena historia clínica y exámenes de laboratorio son importantes para el diagnóstico y tratamiento oportuno.

  5. Caracterización clínica y epidemiológica de fiebre chikungunya en México

    Directory of Open Access Journals (Sweden)

    Carolina Garay-Morán

    2017-08-01

    Full Text Available RESUMEN El 6 de diciembre de 2013, la Organización Panamericana de la Salud (OPS y la Organización Mundial de la Salud (OMS notificaron la confirmación de los dos primeros casos de transmisión autóctona en la Región de las Américas de fiebre chikungunya (CHIK en la isla de Saint Martin (Antillas Neerlandesas. Para el período 2013-2014, el total de casos confirmados fue de 25 627 distribuidos en 43 países, donde México reportó 155 casos en cinco estados. La información de los casos de CHIK en México se obtuvo de la base de datos de la Dirección General de Epidemiología, dependiente de la Secretaría de Salud de México. La distribución por sexo de los casos autóctonos confirmados de CHIK para el año 2015 indica 64% para el sexo femenino (5 583 y 36% para el sexo masculino (3 085. Los síntomas más frecuentes fueron: fiebre en 98% de los casos (8 564, seguido por cefalea con 91,6% (7 941, mialgias en 89,9% (7 792, artralgias leves en 73,5% (6 367, poliartralgias graves en 72,6% (6 295 y exantema en 58% (5 032. La presentación clínica de los casos autóctonos de CHIK en México ha mostrado algunas características clínicas diferentes de las que se han observado en los brotes de los países africanos, asiáticos y otras regiones de América, como por ejemplo un mayor porcentaje de casos con cefalea y mialgias y un menor porcentaje de casos con artralgias.

  6. El virus de la fiebre amarilla “un virus científicamente olvidado”

    OpenAIRE

    Universidad del Rosario, Programa de divulgación científica

    2007-01-01

    La fiebre amarilla es una enfermedad viral propia de regiones subtropicales que afecta principalmente el hígado produciendo hemorragias agudas y daños graves a nivel del tejido; es causada por un virus perteneciente al género Flavivirus, y es transmitida en el núcleo urbano por el mosquito Aedes aegypti, y selváticamente, por mosquitos del género Haemagogus. En Colombia, se presentaron 20 casos en el 2005 de los cuales el 65% fue letal (OMS, 2006) (*). Sobre la fiebre amarilla, se logró ...

  7. Fiebre amarilla: una enfermedad reemergentes en América del Sur 2000 - 2016.

    OpenAIRE

    Lara Torres, Sara Gabriela

    2017-01-01

    Introducción. La fiebre amarilla selvática es una enfermedad zoonótica viral, reemergente de América del Sur que se ha mantenido durante años, a pesar de que exista una vacuna eficaz hace más de 50 años. Objetivo. Identificar los casos confirmados de fiebre amarilla en el continente Suramericano. Materiales y Métodos. Se realizó un estudio descriptivo, de revisión bibliográfica de los casos confirmados de FA en el Continente Sudamericano desde el 2000 hasta el 2016. Obteniendo la información ...

  8. ¿Pueden la malaria y el dengue reaparecer en España? Could malaria and dengue reappear in Spain?

    Directory of Open Access Journals (Sweden)

    Rubén Bueno Marí

    2010-08-01

    Full Text Available El aumento de la inmigración durante los últimos años en España ha facilitado la importación de numerosas enfermedades tropicales. Entre ellas, las de transmisión vectorial son algunas de las más complicadas de estudiar por la complejidad que conlleva la participación de diversos hospedadores en los ciclos de transmisión, así como por la necesidad de conocer todos los parámetros fisiológicos, bioecológicos y biogeográficos relacionados con el organismo vector para poder inferir las posibilidades reales de la emergencia o la reemergencia de las enfermedades pertinentes. En estas circunstancias, el presente trabajo aporta información acerca de enfermedades importadas de incuestionable interés epidemiológico para la población residente en España, por albergar nuestro país diversas especies de mosquitos culícidos (Diptera, Culicidae potencialmente transmisoras de éstas. Enfermedades parasitarias como la malaria, que fue altamente endémica en España hasta hace apenas 50 años, y otras de tipo arbovírico como el dengue y la fiebre amarilla, son analizadas en estos términos. También se exponen diferentes aspectos inherentes al sistema sanitario y a las distintas formas de hacer frente a estas cuestiones.The recent increase in immigration to Spain has facilitated the importation of many tropical diseases. Among these diseases, those of vectorial origin are among the most difficult to study. Some of the reasons for this difficulty are the complexity due to the variety of hosts involved in the transmission cycles and the need to know all the physiological, bioecological and biogeographic parameters related to the vector in order to infer the actual possibilities of the emergence or reemergence of these diseases. This article provides information on imported diseases of unquestionable epidemiological interest for the population in Spain due to the presence of several species of culicid mosquitoes (Diptera, Culicidae capable of

  9. Lugares, actitudes y momentos durante la peste: representaciones sobre la fiebre amarilla y el cólera en la ciudad de Buenos Aires, 1867-1871

    Directory of Open Access Journals (Sweden)

    Maximiliano Ricardo Fiquepron

    Full Text Available Resumen El objetivo de este trabajo es analizar las distintas representaciones que sobre la salud y la enfermedad se asociaron con las epidemias de fiebre amarilla y cólera durante el período 1867-1871 en la ciudad de Buenos Aires. El argumento es que existió un repertorio muy amplio y heterogéneo de representaciones que se condensó en variadas actitudes individuales con la cual se enfrentó la crisis, así como una transformación del espacio y del tiempo social. Para poder sobrellevar esta experiencia traumática se buscó de maneras muy diversas mantener un vínculo social que era también al mismo tiempo una forma de mantener la salud.

  10. Manifestaciones clínicas del dengue hemorrágico en Puerto Rico, 1990-1991 Clinical manifestations of dengue hemorrhagic fever in Puerto Rico, 1990-1991

    Directory of Open Access Journals (Sweden)

    José G. Rigau-Pérez

    1997-06-01

    Full Text Available Este estudio se realizó con el fin de mostrar que el dengue hemorrágico (DH se da en Puerto Rico, si bien es una enfermedad subnotificada, lo que se debe en parte a su subdiagnóstico en los hospitales. La vigilancia de casos graves de dengue permitió determinar que hubo 986 hospitalizaciones por sospecha de dengue en el período de 1990-1991. En esa época, el sistema de vigilancia identificó 20 casos de DH, incluidos tres de síndrome de choque por dengue (SCD. Nuestra subsecuente revisión de los expedientes de los 986 pacientes reveló que en 102 de ellos había razones para apoyar el diagnóstico clínico de DH (88 y de SCD (14. Entre estos 102 había 57 que dieron resultados virológicos o serológicos positivos a dengue y que reunían los criterios de caso de dengue establecidos por la OMS (fiebre, manifestaciones hemorrágicas, trombocitopenia y excesiva permeabilidad capilar. En el grupo de 57 pacientes, la media de edad era de 38 años y preponderaban los hombres (34, o sea 59,3%, incluidos ocho casos de SCD y dos (3,5% defunciones (en mujeres de 16 y 55 años de edad. Los síntomas hemorrágicos fueron leves y con frecuencia se observaron hemoconcentración, hipoalbuminemia y concentraciones elevadas de aspartato y alanina aminotransferasas. Las hospitalizaciones duraron unos 5 días en término medio. La descripción clínica de estos casos de DH en Puerto Rico coincide con descripciones anteriores de la enfermedad en la literatura médica, pero la distribución por edad de los pacientes es similar al patrón que se suele encontrar en las Américas (donde afecta a todos los grupos de edad, en contraste con el de Asia Sudoriental (donde afecta principalmente a niños pequeños. El número de casos identificados en nuestro estudio fue casi tres veces mayor que el número notificado por el sistema de vigilancia establecido. Nuestros resultados indican que es necesario mejorar la capacidad de los clínicos locales para reconocer y

  11. Construyendo buenos ciudadanos con buenas prácticas en salud: dengue e influenza AH1N1 en Cali, Colombia

    Directory of Open Access Journals (Sweden)

    Alejandro Arango

    2013-06-01

    Full Text Available Este artículo discute la relación entre la dimensión biológica de las enfermedades y los hábitos de auto-cuidado o “conductas saludables”. Su pregunta central indaga por cómo un fenómeno aparentemente biológico genera ciertas “buenas prácticas” en torno a la salud, defendiendo la idea de la enfermedad como un asunto socio-cultura, más que un mero hecho biológico. El estudio aquí presentado se apoya en una investigación realizada en la ciudad de Cali y enfocada en dos enfermedades, dengue e influenza AH1N1, entre 2009 y 2010. El examen de la relevancia adquirida por estas dos dolencias, mostrará cómo la biología y las prácticas de auto-cuidado tienen una estrecha relación entre sí.

  12. Outbreak of Paratyphoid Fever Among Naval Personnel in Peru (Brote de Fiebre Paratifoidea Entre Personal de la Marina Del Peru.)

    Science.gov (United States)

    1992-01-01

    son menosde 2Okniquecaiusania nvar comun Cs la tifoidea cldsica producida por S parte de las infecciones hunanas La fiebre Isv’lht la parat-foidea. par...TITLE (Include Secunty Clasifi4tin) Brote de Fiebre Parutifoidea Entre Personal de la Marina del Peru 1.PERSON4AL AUTHORCS) Pazzagllia G; Wgnall FS...CLASSIFIATIO F THIS PAGE All othe~redmtons areobolete. ZINCLASSIITIED Best Avai~lable Copy BROTE Dl FIEBRE PARATIFOIDEA ENTRE PERSONAL DE1 LA MARINA DEL PERU G

  13. Pulmonary affectation in a patient with typhoid fever; Compromiso pulmonar en un paciente con fiebre tifoidea

    Energy Technology Data Exchange (ETDEWEB)

    Duenas C, Carmelo; Martinez, Adel; Maza, Augusto

    1997-04-01

    Typhoid fever is a rare disease in the USA with no more of 500 cases per year. In Latin America, it occurs four to five times more frequently. Pulmonary symptoms are found in less than 20% of the cases. The development of pneumonia is more common in immunocompromised patients. In last 10 years, the frequency of typhoid pneumonia has increased because of the HIV epidemic and the advance of other forms of immunosuppression. We presented the case of a young adult male with typhoid multilobar pneumonia who did not have VIH infection or any demonstrated immunosuppression.

  14. Dengue encephalitis–A rare manifestation of dengue fever

    OpenAIRE

    Madi, Deepak; Achappa, Basavaprabhu; Ramapuram, John T; Chowta, Nityananda; Laxman, Mridula; Mahalingam, Soundarya

    2014-01-01

    The clinical spectrum of dengue fever ranges from asymptomatic infection to dengue shock syndrome. Dengue is classically considered a non-neurotropic virus. Neurological complications are not commonly seen in dengue. The neurological manifestations seen in dengue are encephalitis, meningitis, encephalopathy, stroke and Guillain-Barré syndrome. Dengue encephalitis is a rare disease. We report an interesting case of dengue encephalitis from Southern India. A 49-year-old gentleman presented with...

  15. Dengue Fever/Dengue Haemorrhagic Fever : Case Management

    OpenAIRE

    Nimmannitya, Suchitra

    1995-01-01

    Dengue infections caused by the four antigenically distinct dengue virus serotypes (dengue virus 1, dengue virus 2, dengue virus 3, dengue virus 4) of the family Flavivindae, are the most important arbovirus disease in man, both in terms of morbidity and mortality. The infection is transmitted from man to man by Aedes mosquitoes. Since 1956, dengue virus infection has resulted in more than 3 million hospital admissions and more than 50,000 deaths in Southeast Asia, Western Pacific countries, ...

  16. Vacuna contra la fiebre hemorrágica argentina Candid#1 producida en la Argentina: Inmunogenicidad y seguridad

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    Delia A. Enria

    2010-06-01

    Full Text Available Se realizó un estudio clínico en 946 voluntarios humanos sanos, donde se comparó la vacuna Candid#1 producida en Argentina con la elaborada en EE.UU., que había sido utilizada en estudios previos. Como objetivo primario se evaluó la equivalencia en la eficacia utilizando como marcador subrogante a la inmunogenicidad medida por detección de anticuerpos neutralizantes. Como objetivo secundario se evaluó la equivalencia en inocuidad comparando las tasas de reacciones adversas. Ambas vacunas mostraron una tasa equivalente de inmunogenicidad ligeramente superior al 95.5%, que es la eficacia estimada para Candid #1 en estudios previos. No se observaron eventos adversos graves relacionados con la vacuna. Los eventos adversos generales considerados relacionados fueron de escasa significación clínica y de resolución espontánea o con tratamiento sintomático; se presentaron en los receptores de ambas vacunas en tasas equivalentes (29.9% para la vacuna fabricada en la Argentina y 35.0% para la fabricada en EE.UU., e incluyeron: cefalea, decaimiento, mialgias, plaquetopenia leve (< 150 000 plaquetas/mm³, náuseas y/o vómitos, leucopenia leve (< 4 000 blancos/mm³, fiebre, dolor retroocular, mareos, microhematuria, lumbalgia y exantema. Estos resultados indican que la vacuna Candid #1 elaborada en la Argentina es equivalente a la elaborada en los EE.UU. Este estudio permitió el registro del biológico producido en la Argentina ante la autoridad regulatoria del país (ANMAT.

  17. Dengue fever (image)

    Science.gov (United States)

    Dengue fever, or West Nile fever, is a mild viral illness transmitted by mosquitoes which causes fever, ... second exposure to the virus can result in Dengue hemorrhagic fever, a life-threatening illness.

  18. Evaluación de un método inmunohistoquímico para el diagnóstico de la fiebre amarilla

    Directory of Open Access Journals (Sweden)

    Orlando Ricaurte

    1993-03-01

    Full Text Available La confirmación diagnóstica de casos fatales de fiebre amarilla (FA es esencial en los programas de vigilancia epidemiológica de la entidad, en regiones endémicas. Se evaluó un método inmunohistoquímico para la detección de antígeno viral de FA en cortes de tejido fijados en formo1 e incluidos en parafina. Aplicamos el procedimiento a 59 casos, con criterios clínico-patológicos y epidemiológicos de FA, dos de ellos con aislamiento viral, ocurridos en Colombia entre 1934 y 1992, incluyendo casos típicos y tardíos. La sensibilidad del método fue del 98,30% : 58 casos fueron positivos mientras que un caso con importantes cambios de autólisis fue negativo. Por Otra parte, se seleccionaron 10 hígados con patologías diferentes, incluyendo 4 con hepatitis fulminante por coinfección de virus de la hepatitis B y delta, ninguno de los cuales mostró inmunorreactividad (especificidad: 100%. Estos resultados indican que este método es un recurso útil para la confirmación del diagnóstico histopatológico de la FA.

  19. Dengue viruses in Brazil, 1986-2006 Virus del dengue en Brasil, 1986-2006

    Directory of Open Access Journals (Sweden)

    Rita Maria Ribeiro Nogueira

    2007-11-01

    Full Text Available A total of 4 243 049 dengue cases have been reported in Brazil between 1981 and 2006, including 5 817 cases of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS and a total of 338 fatal cases. Although all Brazilian regions have been affected, the Northeast and Southeast regions have registered the highest number of notifications. DENV-1 and DENV-4 were isolated for the first time in the Amazon region of Brazil in 1981 and 1982. The disease became a nationwide public health problem following outbreaks of DENV-1 and DENV-2 in the state of Rio de Janeiro in 1986 and 1990, respectively. The introduction of DENV-3 in 2000, also in the state of Rio de Janeiro, led to a severe epidemic with 288 245 reported dengue cases, including 91 deaths. Virus strains that were typed during the 2002 epidemic show that DENV-3 has displaced other dengue virus serotypes and entered new areas, a finding that warrants closer evaluation. Unusual clinical symptoms, including central nervous system involvement, have been observed in dengue patients in at least three regions of the country.En Brasil se han notificado 4 243 049 casos de dengue entre 1981 y 2006, de ellos 5 817 casos de dengue hemorrágico/síndrome de choque por dengue (DH/SCD y un total de 338 casos mortales. A pesar de que la enfermedad ha afectado a todas las regiones brasileñas, el mayor número de casos se ha notificado en las regiones nororiental y suroriental. Los virus del dengue (DENV 1 y 4 se aislaron por primera vez en la región amazónica de Brasil en 1981 y 1982. La enfermedad se convirtió en un problema nacional de salud pública después de los brotes de DENV-1 y DENV-2 en el Estado de Río de Janeiro en 1986 y 1990, respectivamente. La introducción del DENV-3 en 2000, también en el Estado de Río de Janeiro, llevó a una grave epidemia con 288 245 casos notificados de dengue y 91 muertes. Las cepas del virus identificadas durante la epidemia de 2002 demostraron que el DENV-3 ha

  20. Epidemiología molecular del dengue en las Américas

    OpenAIRE

    Francisco Javier Díaz Castrillón

    2004-01-01

    Después de varias décadas de erradicación, el dengue se ha hecho endémico en la mayor parte de la América tropical y presenta tendencia al crecimiento en la mayoría de los países. La enfermedad ha sufrido un cambio en su expresión clínica en las últimas dos décadas. Una forma grave inexistente hasta los años 80 conocida como fiebre hemorrágica dengue (FHD) se ha diseminado primero por las Antillas, luego en Sur...

  1. Psychosis in dengue fever

    OpenAIRE

    Suprakash Chaudhury; Biswajit Jagtap; Deepak Kumar Ghosh

    2017-01-01

    An 18-year-old male student developed abnormal behavior while undergoing treatment for dengue fever. He was ill-kempt, irritable and had auditory and visual hallucinations and vague persecutory delusions in clear sensorium with impaired insight. The psychotic episode had a temporal correlation with dengue fever. Psychiatric comorbidities of dengue fever including mania, anxiety, depression, and catatonia are mentioned in literature but the literature on the psychosis following dengue is spars...

  2. Post-dengue parkinsonism

    OpenAIRE

    Azmin, Shahrul; Sahathevan, Ramesh; Suehazlyn, Zainudin; Law, Zhe Kang; Rabani, Remli; Nafisah, Wan Yahya; Tan, Hui Jan; Norlinah, Mohamed Ibrahim

    2013-01-01

    Background Dengue is a common illness in the tropics. Equally common are neurological complications that stem from dengue infection. However, to date, parkinsonism following dengue has not been reported in medical literature. Case presentation A previously well 18-year old man developed parkinsonism, in addition to other neurological symptoms following serologically confirmed dengue fever. Alternative etiologies were excluded by way of imaging and blood investigations. Conclusions The authors...

  3. Dengue virus receptor

    OpenAIRE

    Hidari, Kazuya I.P.J.; Suzuki, Takashi

    2011-01-01

    Dengue virus is an arthropod-borne virus transmitted by Aedes mosquitoes. Dengue virus causes fever and hemorrhagic disorders in humans and non-human primates. Direct interaction of the virus introduced by a mosquito bite with host receptor molecule(s) is crucial for virus propagation and the pathological progression of dengue diseases. Therefore, elucidation of the molecular mechanisms underlying the interaction between dengue virus and its receptor(s) in both humans and mosquitoes is essent...

  4. Caracterización genética del virus de la fiebre amarilla proveniente de un brote icterohemorrágico en una comunidad nativa del distrito de Imaza, Amazonas, 2005

    OpenAIRE

    Yábar, Carlos; Mamani, Enrique

    2006-01-01

    La fiebre amarilla (FA) sigue siendo una enfermedad de importancia en salud pública en el mundo a pesar de la existencia de una vacuna eficaz (WHO, 2005). En Sudamérica, el Perú fue uno de los países que registró el mayor número de casos de FA durante el 2004 (WHO, 2005), contando con zonas endémicas que se extienden desde la selva norte hacia la selva central. Recientemente, en diciembre de 2005 la Dirección de Salud (DISA) de Bagua tomó conocimiento de un brote icterohemorrágico en la co...

  5. Dengue in children

    NARCIS (Netherlands)

    Verhagen, L.M.; Groot, R. de

    2014-01-01

    Dengue is a mosquito-borne viral disease of expanding geographical range and increasing incidence. The vast majority of dengue cases are children less than 15 years of age. Dengue causes a spectrum of illness from mild fever to severe disease with plasma leakage and shock. Infants and children with

  6. Nuevas observaciones sobre un tercer foco de fiebre petequial en el hemisferio americano

    Directory of Open Access Journals (Sweden)

    Luis Patiño Camargo

    1941-11-01

    Full Text Available Se ha localizado un foco endémico de Rickettsiasis y se ha denominado fiebre petequial de Tobia, en el interior de Colombia, en zona rural calida de la hoya del Magdalena, a 118 kilómetros de Bogotá. La comarca es fértil, pero las condiciones de vida humana son precarias. El índice de mortalidad por la fiebre petequial de Tobia, es de 95%. Ocurre principalmente en individuos de 20 a 29 años de edad, sin distincion de sexos. Hay epidemias familiares. Las gentes considerando que el contagio reside en las chozas y enseres, cuando se repiten las muertes, incineran las viviendas. Abundan ectoparásitos humanos y animales.

  7. Adolescente femenino con granulomatosis de Wegener fulminante

    Directory of Open Access Journals (Sweden)

    S C Scheffler-Mendoza

    2017-01-01

    Full Text Available Adolescente femenino de 13 años de edad, originaria de Guerrero, grupo étnico mixteco, padres analfabetos y con poco entendimiento del español. Sin otros antecedentes de importancia para el padecimiento. Inició un mes previo con la aparición de una pápula hipercrómica en párpado superior derecho que en los 10 días previos al ingreso aumentó de volumen generando proptosis. Al interrogatorio se negó dolor, lagrimeo, fiebre, o pérdida de peso. Ingresó con fiebre (39.0°C, palidez generalizada, proptosis derecha con exposición de córnea y conjuntiva, eritema periorbitario, movimientos oculares y agudeza visual disminuidos (i.e. contaba dedos a 1 m, pupila con tendencia a midriasis, hiperreactividad a la luz, y fondo de ojo con papila hiperémica edematosa y tortuosidad peripapilar. El resto de exploración no mostró datos relevantes. Se hospitalizó para iniciar tratamiento antimicrobiano parenteral de amplio espectro (i.e. ceftriaxona y vancomicina y abordar proptosis unilateral.

  8. Dengue viral infections

    OpenAIRE

    Gurugama Padmalal; Garg Pankaj; Perera Jennifer; Wijewickrama Ananda; Seneviratne Suranjith

    2010-01-01

    Dengue viral infections are one of the most important mosquito-borne diseases in the world. Presently dengue is endemic in 112 countries in the world. It has been estimated that almost 100 million cases of dengue fever and half a million cases of dengue hemorrhagic fever (DHF) occur worldwide. An increasing proportion of DHF is in children less than 15 years of age, especially in South East and South Asia. The unique structure of the dengue virus and the pathophysiologic responses of the host...

  9. Dengue en Panamá, 1993

    OpenAIRE

    QUIROZ, EVELIA; ORTEGA, MARITZA; GUZMÁN, MARÍA GUADALUPE; VÁZQUEZ, SUSANA; PELEGRINO, JOSÉ LUIS; CAMPOS, CORNELIO; BAYARD, VICENTE; VÁZQUEZ, MANUEL; KOURÍ, GUSTAVO

    1997-01-01

    Hasta 1993, Panamá era el único país de Centroamérica que había detectado transmisión autóctona de virus dengue sin experimentar una epidemia explosiva, pese a estar reinfestado con el mosquito Aedes aegypti desde 1985. En este trabajo se describen las características de este primer brote reportado el 19 de noviembre de 1993 y se demuestra que las epidemias se presentan a pesar de mantener un Programa de Vigilancia y Control para Dengue -que contempla bajos niveles de infestación del Aedes ae...

  10. Fiebre del oro blanco: la cocaína

    Directory of Open Access Journals (Sweden)

    Iván Marín Argüello

    1999-12-01

    Full Text Available La planta de coca, Erythroxylon coca es cultivada en la zona occidental de América del Sur exigiendo condiciones de suelo muy particulares. La mezcla de las hojas de cocaína con sustancias químicas origina un polvo cristalino blanco, conocido comúnmente como cocaína. Al producto obtenido del tratamiento de la cocaína con solventes se le denomina crack. El consumo de cocaína, las formas de administración más diversas y el estado fisiológico logrado por los usuarios, es denominado flash 0 high Los efectos neuro-fisiológicos son muy variados, provocando sobre todo un fuerte estímulo al Sistema Nervioso Central (SNC, producto de la liberación de dopamina en las terminaciones nerviosas.

  11. Dengue in children.

    Science.gov (United States)

    Verhagen, Lilly M; de Groot, Ronald

    2014-11-01

    Dengue is a mosquito-borne viral disease of expanding geographical range and increasing incidence. The vast majority of dengue cases are children less than 15 years of age. Dengue causes a spectrum of illness from mild fever to severe disease with plasma leakage and shock. Infants and children with secondary heterologous dengue infections are most at risk for severe dengue disease. Laboratory diagnosis of dengue can be established within five days of disease onset by direct detection of viral components in serum. After day five, serologic diagnosis provides indirect evidence of dengue. Currently, no effective antiviral agents are available to treat dengue infection. Therefore, treatment remains supportive, with emphasis on close hematological monitoring, recognition of warning signs of severe disease and fluid-replacement therapy and/or blood transfusions when required. Development of a dengue vaccine is considered a high public health priority. A safe and efficacious dengue vaccine would also be important for travelers. This review highlights the current understanding of dengue in children, including its clinical manifestations, pathogenesis, diagnostic tests, management and prevention. Copyright © 2014 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

  12. Autoimmunity in dengue pathogenesis

    Directory of Open Access Journals (Sweden)

    Shu-Wen Wan

    2013-01-01

    Full Text Available Dengue is one of the most important vector-borne viral diseases. With climate change and the convenience of travel, dengue is spreading beyond its usual tropical and subtropical boundaries. Infection with dengue virus (DENV causes diseases ranging widely in severity, from self-limited dengue fever to life-threatening dengue hemorrhagic fever and dengue shock syndrome. Vascular leakage, thrombocytopenia, and hemorrhage are the major clinical manifestations associated with severe DENV infection, yet the mechanisms remain unclear. Besides the direct effects of the virus, immunopathogenesis is also involved in the development of dengue disease. Antibody-dependent enhancement increases the efficiency of virus infection and may suppress type I interferon-mediated antiviral responses. Aberrant activation of T cells and overproduction of soluble factors cause an increase in vascular permeability. DENV-induced autoantibodies against endothelial cells, platelets, and coagulatory molecules lead to their abnormal activation or dysfunction. Molecular mimicry between DENV proteins and host proteins may explain the cross-reactivity of DENV-induced autoantibodies. Although no licensed dengue vaccine is yet available, several vaccine candidates are under development. For the development of a safe and effective dengue vaccine, the immunopathogenic complications of dengue disease need to be considered.

  13. Dengue-associated neuromuscular complications

    OpenAIRE

    Ravindra Kumar Garg; Hardeep Singh Malhotra; Amita Jain; Kiran Preet Malhotra

    2015-01-01

    Dengue is associated with many neurological dysfunctions. Up to 4% of dengue patients may develop neuromuscular complications. Muscle involvement can manifest with myalgias, myositis, rhabdomyolysis and hypokalemic paralysis. Diffuse myalgia is the most characteristic neurological symptom of dengue fever. Dengue-associated myositis can be of varying severity ranging from self-limiting muscle involvement to severe dengue myositis. Dengue-associated hypokalemic paralysis often has a rapidly evo...

  14. Protocolo diagnóstico en fiebre de origen desconocido para países en vías de desarrollo

    Directory of Open Access Journals (Sweden)

    Jesús Romo

    2004-06-01

    Full Text Available Signos vitales, como la fiebre, suelen ser motivo de frustración para el binomio médico-paciente; por ello, es indispensable tener en mente una serie de pasos a seguir que nos encaminen al diagnóstico etiológico de esta modalidad patológica. No podemos enfrentar tal padecimiento siguiendo ordenadamente los protocolos recomendados por autores de primer mundo, porque muchas de las veces nos quedamos a mitad del camino, constituyendo con esto una pérdida de tiempo y frustración. Es por eso que surge la necesidad de reorganizar un protocolo bien establecido para ello. En este trabajo, se reorganiza el protocolo diagnóstico establecido por la literatura anglosajona para deducir el factor etiológico en Fiebre de Origen Desconocido (FOD. La mayoría de los autores expertos en el tema recomienda cuatro fases diagnósticas divididas según las herramientas (tecnológicas y científicas de diagnóstico; la intención de esta revisión es reagrupar la modalidad diagnóstica y que sea de buen provecho para las unidades hospitalarias de América Latina y otros países que están en vías de desarrollo. Presentamos un formato fácil de seguir y que sin duda dará buenos resultados para el rastreo etiológico de este problema.

  15. Dengue and dengue haemorrhagic fever: Indian perspective

    Indian Academy of Sciences (India)

    PRAKASH KUMAR

    mainly in children (Halstead 2002, 2007; Chaturvedi and. Shrivastava 2004). Dengue ... of molecular epidemiology, immunopathology and vaccine development. Selected work done in ..... Only the Indian initiative in this field is presented here.

  16. Dengue and Calcium

    OpenAIRE

    Shivanthan, Mitrakrishnan C; Rajapakse, Senaka

    2014-01-01

    Dengue is potentially fatal unless managed appropriately. No specific treatment is available and the mainstay of treatment is fluid management with careful monitoring, organ support, and correction of metabolic derangement. Evidence with regards to the role of calcium homeostasis in dengue is limited. Low blood calcium levels have been demonstrated in dengue infection and hypocalcemia maybe more pronounced in more severe forms. The cause of hypocalcemia is likely to be multifactorial. Calcium...

  17. Brote de fiebre amarilla selvática en Colombia 2004

    Directory of Open Access Journals (Sweden)

    Pilar Bernal M.

    2004-03-01

    Full Text Available

    Antecedentes: el 9 de enero se confirma un caso de fiebre amarilla en la sierra nevada de Santa Marta cuya circulación viral es la continuación de la presentada en el 2003 en la región del Catatumbo. En la región no se confirmaban casos desde el año 1979 y el comportamiento del brote es similar al presentado en dicho año.

    Metodología: estudio descriptivo longitudinal de casos captados mediante vigilancia activa comunitaria, estudio de casos y vigilancia pasiva. Los casos son confirmados por IgM, inmunohistoquímica y patología. Se realizaron acciones del fortalecimiento de la vigilancia de febriles icterohemorrágicos, entomológica, vectorial y de epizootias. Igualmente acciones de intensificación de la inmunización de susceptibles y educación a la comunidad.

    Resultados: se confirmó la circulación del virus en epizootias ocurridas en tres zonas de la región (Municipios de Valledupar, La Paz y Santa Marta. Por fecha de inicio de síntomas los casos comenzaron en la semana 51 de 2003 y el pico epidémico fue en la semana 1 de 2004; el último caso se confirmó el 22 de enero de 2004. Se confirmaron 29 casos de 787 notificados (15 del distrito de Santa Marta, 8 del departamento del Cesar y 6 de La Guajira; 20% de los casos fueron captados por vigilancia activa. El 28% fue confirmado por patología e inmunohistoquímica y el restante por IgM. El grupo de edad con mayor incidencia fue 15 a 44 años (75%, hombres (72% y agricultores (45%. La letalidad fue 28%.

    La vigilancia entomológica reportó la presencia de Sabethes s.p en Valledupar y los índice médicos, excepto en esta última ciudad, fueron mayores del 10%. Las coberturas de

  18. Epidemiología molecular del dengue en las Américas

    Directory of Open Access Journals (Sweden)

    Francisco Javier Díaz Castrillón

    2004-03-01

    Full Text Available

    Después de varias décadas de erradicación, el dengue se ha hecho endémico en la mayor parte de la América tropical y presenta tendencia al crecimiento en la mayoría de los países. La enfermedad ha sufrido un cambio en su expresión clínica en las últimas dos décadas. Una forma grave inexistente hasta los años 80 conocida como fiebre hemorrágica dengue (FHD se ha diseminado primero por las Antillas, luego en Suramérica y más tarde en Centroamérica y Méjico, convirtiéndose en un problema significativo para la salud pública del continente. Las causas del aumento en la virulencia de la enfermedad producida por el virus del dengue (DENV solo se conocen parcialmente. La potenciación de la enfermedad por acción de la inmunidad previa a serotipos diferentes al causante de la infección actual fue demostrada en el sureste asiático, pero no ha sido muy estudiada en las Américas. Además, este mecanismo no provee una explicación completa, puesto que FHD se ha observado también en personas que se infectan por primera vez, y la infección secundaria no siempre resulta en un cuadro severo.

    La epidemiología molecular permite correlacionar la variación genética del agente infeccioso con los eventos epidemiológicos en un marco espacio-temporal. Utilizando técnicas moleculares es posible clasificar las diferentes cepas de cada serotipo del DENV en tres a seis subtipos o “genotipos”. Estos genotipos generalmente están segregados geográficamente pero ocasionalmente son introducidos en países o continentes que no los habían detectado previamente. Estos episodios migratorios pueden o no ir acompañados de cambios en la frecuencia y en la expresión clínica de la enfermedad.

    En las Américas, sólo se ha detectado

  19. Estratificación de una ciudad hiperendémica en dengue hemorrágico Stratification of a city with hyperendemic dengue hemorrhagic fever

    Directory of Open Access Journals (Sweden)

    Roberto Barrera

    2000-10-01

    Full Text Available La gran heterogeneidad ambiental de viviendas y barrios en los centros urbanos donde se cría Aedes aegypti, principal vector del dengue, junto con la escasez de recursos y de personal entrenado en el control de mosquitos constituyen retos para cualquier iniciativa destinada a controlar el dengue hemorrágico (DH. Una adecuada vigilancia epidemiológica puede servir de base para comenzar a estratificar los centros urbanos e identificar las zonas críticas donde deben concentrarse las tareas de control. En este estudio, se estratificó una ciudad hiperendémica en dengue hemorrágico (Maracay, Venezuela con la ayuda de un sistema de información geográfica (SIG y el análisis de la persistencia, la incidencia y la prevalencia del dengue mediante diagnósticos clínicos registrados de 1993 a 1998. Maracay tiene cerca de un millón de habitantes que viven en unos 349 barrios de 6 poblaciones que integran el Área Metropolitana, donde se notificaron 10 576 casos de dengue, 2 593 casos de DH y 8 defunciones. La incidencia de DH mostró una relación directa con la incidencia del dengue, el número de habitantes y la densidad poblacional. El patrón espacial de la incidencia del dengue fue estable durante los años estudiados y se encontraron relaciones positivas y significativas de la incidencia del dengue por barrio entre pares de años. La persistencia del dengue se relacionó directamente con la incidencia mensual por barrio. Estos patrones espaciales facilitaron la estratificación de la ciudad en tres estratos: 68 barrios sin dengue aparente, 226 barrios con baja persistencia y prevalencia, y 55 barrios con alta persistencia y prevalencia. Se recomienda otorgar alta prioridad de control a estos 55 barrios que ocupan 35% del área urbana y presentaron 70% de todos los casos de dengue.Any effort to control dengue hemorrhagic fever (DHF faces a number of challenges. Among these are the great environmental heterogeneity of homes and neighborhoods

  20. Efectos nocivos de la fiebre en el niño y medidas terapéuticas

    Directory of Open Access Journals (Sweden)

    Lourdes B. Alpízar Caballero

    1998-12-01

    Full Text Available Con el propósito de ofrecer a los pediatras, residentes y especialistas de Medicina General Integral una información sobre las principales tendencias actuales en el manejo y conducta terapéutica en el niño febril, se analizan algunas consideraciones de interés para la aplicación del tratamiento antipirético y los métodos farmacológicos y físicos en la antipiresis. En el método farmacológico se presentan los 3 principales grupos de medicamentos antipiréticos: salicilatos, aminofenoles y derivados del ácido propiónico. De ellos se exponen las dosis, contraindicaciones y efectos adversos. Se señalan entre los efectos nocivos de la fiebre en el niño, el daño al sistema nervioso central, la afectación de otros órganos y sistemas y el malestar general.Several interesting considerations for the use of the antipyretic treatment, and of the pharmacological and physical methods in antipyresis, are analyzed with the aim of giving information to pediatricians, residents, and physicians specialized in Integral General Medicine about the main current trends in the management and therapeutic behaviour in the febrile child. In the pharmacological method the three main groups of antipyretic medicines are present: salicylates, aminophenols, and propionic acid derivatives. Doses, contraindications, and side effects of such are exposed. Adverse effects of the fever in the child, damage to the central nervous system, affectation of other organs and systems, and general indisposition, are pointed out.

  1. Fiebre de origen desconocido, una forma de presentarse la tuberculosis Fever of unknown origin as a form of presentation of tuberculosis

    Directory of Open Access Journals (Sweden)

    Lázaro Arturo Vidal Tallet

    2012-12-01

    Full Text Available La tuberculosis es una causa importante de fiebre de origen desconocido. Dentro de los factores de riesgo para estar infectado por el bacilo tuberculoso se encuentra la edad, la presencia de comorbilidades, la competencia inmunológica y la alta prevalencia de la enfermedad en el área geográfica. Los hallazgos clínicos, radiológicos, epidemiológicos y la respuesta a la terapéutica antimicrobiana, pueden orientar en el diagnóstico de esta enfermedad infecciosa. Se presenta un caso en el que los elementos clínicos y epidemiológicos (padre con diagnóstico de tuberculosis llevaron finalmente a la sospecha diagnóstica de tuberculosis extra pulmonar, que no pudo ser demostrada por cultivo, pero la respuesta terapéutica resultó concluyente, ya que, una vez iniciada esta, hubo total remisión del cuadro clínico y recuperación nutricional. La terapia antituberculosa con carácter terapéutico y diagnóstico debe ser considerada en todo paciente con fiebre de origen desconocido, que, además, presente elementos clínicos y epidemiológicos que justifiquen la posibilidad de infección por el bacilo.Tuberculosis is an important cause of fever of unknown origin. Among the risk factors of getting infected by the tuberculosis bacillus are age, presence of comorbidities, immunological competence and high prevalence of the disease in a geographical area. The clinical, radiological and epidemiological findings along with the response to antimicrobial treatment can guide the physician to the correct diagnosis of this infectious disease. Here is a case in which the clinical and epidemiological elements (the father of the patient diagnosed with tuberculosis led to diagnostic suspicion of extrapulmonary tuberculosis. It was not possible to demonstrate it by culturing, but the response to therapy was conclusive, since once the treatment began, there were total remission of the clinical picture and nutritional recovery. The therapeutically and

  2. Dengue-associated kidney disease.

    Science.gov (United States)

    Lizarraga, Karlo J; Nayer, Ali

    2014-01-01

    A mosquito-borne viral illness highly prevalent in the tropics and subtropics, dengue is considered a major global health threat by the World Health Organization. Directory of Open Access Journals (DOAJ), Google Scholar, PubMed (NLM), LISTA (EBSCO) and Web of Science have been searched. An RNA virus from the genus Flavivirus, dengue virus is transmitted by Aedes aegypti,the yellow fever mosquito. Dengue is asymptomatic in as many as one half of infected individuals. Dengue fever is an acute febrile illness accompanied by constitutional symptoms. Dengue hemorrhagic fever and dengue shock syndrome are the severe forms of dengue infection.Dengue infection has been associated with a variety of renal disorders. Acute renal failure is a potential complication of severe dengue infection and is typically associated with hypotension, rhabdomyolysis, or hemolysis. Acute renal failure complicates severe dengue infection in 2-5% of the cases and carries a high mortality rate. Proteinuria has been detected in as high as 74% of patients with severe dengue infection. Hematuria has been reported in up to 12.5% of patients. Various types of glomerulonephritis have been reported during or shortly after dengue infection in humans and mouse models of dengue infection. Mesangial proliferation and immune complex deposition are the dominant histologic features of dengue-associated glomerulonephritis. On a rare occasion, dengue infection is associated with systemic autoimmune disorders involving the kidneys. In the vast majority of cases, dengue infection and associated renal disorders are self-limited.

  3. Prevalencia y curso clínico de la infección por dengue en adultos mayores con cuadro febril agudo en un hospital de alta complejidad en Cali, Colombia

    Directory of Open Access Journals (Sweden)

    Fernando Rosso

    2016-08-01

    Conclusión. La infección por dengue fue frecuente en adultos mayores como causa de síndrome febril agudo. Una importante proporción requirió hospitalización y presentó complicaciones, sin embargo, el manejo adecuado evitó los casos fatales.

  4. Dengue viral infections

    Directory of Open Access Journals (Sweden)

    Gurugama Padmalal

    2010-01-01

    Full Text Available Dengue viral infections are one of the most important mosquito-borne diseases in the world. Presently dengue is endemic in 112 countries in the world. It has been estimated that almost 100 million cases of dengue fever and half a million cases of dengue hemorrhagic fever (DHF occur worldwide. An increasing proportion of DHF is in children less than 15 years of age, especially in South East and South Asia. The unique structure of the dengue virus and the pathophysiologic responses of the host, different serotypes, and favorable conditions for vector breeding have led to the virulence and spread of the infections. The manifestations of dengue infections are protean from being asymptomatic to undifferentiated fever, severe dengue infections, and unusual complications. Early recognition and prompt initiation of appropriate supportive treatment are often delayed resulting in unnecessarily high morbidity and mortality. Attempts are underway for the development of a vaccine for preventing the burden of this neglected disease. This review outlines the epidemiology, clinical features, pathophysiologic mechanisms, management, and control of dengue infections.

  5. Post dengue neurological complication

    Directory of Open Access Journals (Sweden)

    Hizlinda Tohid

    2015-12-01

    Full Text Available Dengue infection is highly endemic in many tropical countries including Malaysia. However, neurological complications arising from dengue infection is not common; Gullain–Barre syndrome (GBS is one of these infrequent complications. In this paper, we have reported a case in which a 39-year-old woman presented with a neurological complication of dengue infection without typical symptoms and signs of dengue fever. She had a history of acute gastroenteritis (AGE followed by an upper respiratory tract infection (URTI weeks prior to her presentation rendering GBS secondary to the post viral URTI and AGE as the most likely diagnosis. Presence of thrombocytopenia was the only clue for dengue in this case.

  6. Epidemiologi dan Diagnosis Dengue di Indonesia

    OpenAIRE

    Zilhadia, Zilhadia

    2007-01-01

    Dengue fever/DF and dengue hemorrhagic fever/DHF is a global public health problem that occured in tropical and subtropical region. Epidemic dengue occurs every years, and it continues to be a major health problem in Indonesia. Due to its asymptomatic nature, a reliable, rapid and accurate dengue diagnosis is needed. Dengue diagnosis method based on molecular dengue virus properties and it will be developed by researcher. Dengue rapid test isnewly method. This article explaine about dengue ep...

  7. Las 'fiebres del Magdalena': medicina y sociedad en la construcción de una noción médica colombiana, 1859-1886 'Magdalena fevers': medicine and society in the construction of a Colombian medical notion, 1859-1886

    Directory of Open Access Journals (Sweden)

    Claudia Mónica García

    2007-03-01

    Full Text Available Explora los fundamentos teóricos, sociales e ideológicos del surgimiento y consolidación de la noción médica colombiana 'fiebres del Magdalena'. Muestra cómo el naciente cuerpo médico colombiano elaboró unas nociones peculiares sobre las fiebres articulando las teorías médicas europeas con la valoración negativa sobre el clima cálido. Explica la forma en que las políticas librecambistas de mediados de siglo así como el impacto económico e ideológico del boom agro exportador del tabaco y el añil determinaron el interés de los médicos por las epidemias ocurridas en los centros productores de estos bienes y, por tanto, el surgimiento de la noción 'fiebres del Magdalena'. Muestra cómo los médicos establecieron una asociación causal entre el proceso productivo de dichos artículos y las fiebres.In this article, I explore the theoretical, social and ideological bases of the emergence and consolidation of the Colombian medical notion of the 'Magdalena fevers'. Firstly I show how, in the late 1850s, the emerging Colombian body of medical doctors elaborated peculiar notions on fevers by articulating the European medical theories (i.e. the miasmatic theory and the climatic determination of diseases with the negative valuation of the hot climate. Secondly, I explain how free trade policies in the mid-1800s, and the economic and ideological impacts of the agricultural export of tobacco and indigo determined doctors' interest in the epidemics occurring in the production centers and also, therefore, the emergence of the notion of 'Magdalena fevers'. I also show how doctors established a causal association between the productive process of those goods and the fevers.

  8. Virus del dengue: estructura y ciclo viral Dengue virus: structure and viral cycle

    Directory of Open Access Journals (Sweden)

    Myriam L Velandia

    2011-03-01

    Full Text Available El virus del dengue (DENV es el agente causal de la enfermedad conocida como dengue, que es la principal enfermedad viral transmitida por artrópodos en el mundo. El DENV es un flavivirus que ingresa por endocitosis y se replica en el citoplasma de la célula infectada, originando tres proteínas estructurales y siete proteínas no estructurales, sobre las cuales se conocen sólo algunas de sus funciones en la replicación viral o en la infección. El ciclo viral que ocurre en las células infectadas hasta ahora está comenzando a aclararse y su conocimiento permitirá en el futuro próximo diseñar racionalmente moléculas que lo intervengan y eviten la replicación del virus. Durante la infección, el individuo puede presentar fiebre indiferenciada o, en otros casos, puede presentar un proceso generalizado de activación de la respuesta inmunitaria innata y adquirida, lo cual provoca la liberación de factores inflamatorios solubles que alteran la fisiología de los tejidos, principalmente el endotelio, conllevando al desarrollo de manifestaciones clínicas graves. Aunque se ha identificado un gran número de factores del individuo asociados al desarrollo de la enfermedad por DENV, queda por identificar el papel de las diferentes proteínas virales en la patogenia de la enfermedad. En la presente revisión, se presenta una breve actualización sobre la estructura y biología del DENV, de su ciclo viral intracelular y, finalmente, se introducen algunos conceptos sobre la inmunopatogenia de la enfermedad producida por este agente.Dengue virus (DENV is responsible for the clinical entity known as dengue that is a great concern for economy and public health of tropical countries. This flavivirus is a single strand RNA virus that after their translation and replication in host cells produces three structural and seven non-structural proteins with specific function in replication or cell binding process that we will describe here. Intracellular

  9. La inequidad en salud: el caso del dengue

    Directory of Open Access Journals (Sweden)

    Veerle Vanlerberghe

    2013-10-01

    Full Text Available Las poblaciones pobres sufren una dimensión desproporcionadamente alta de la carga de enfermedad producida por las enfermedades tropicales desatendidas, dentro de ellas el dengue. La carga de enfermedad por dengue es alta entre los pobres debido a que frecuentemente viven en comunidades donde los vectores son abundantes, porque utilizan menos barreras humano-vectores y, además, por el hecho que las intervenciones suelen ser menos efectivas en estas poblaciones. Consideramos que un mejor entendimiento y manejo de “las causas detrás de las causas” del dengue conducirían a estrategias de control más equitativas y efectivas. En este artículo se desarrollan dos ideas principales: en primer lugar se propone que las intervenciones sean dirigidas a áreas geográficas bien definidas con alto riesgo de transmisión de dengue; dicha definición debería basarse en información socioeconómica, entomológica, ambiental y epidemiológica. En segundo lugar, existe la necesidad de adaptar las herramientas de control de dengue a factores específicos del contexto local, lo cual debe desarrollarse en colaboración activa con los sectores involucrados en el manejo de riesgo, así como con las comunidades afectadas.

  10. Desarrollo y evaluación de una prueba de reacción en cadena de la polimerasa (PCR, utilizando la secuencia del gen hilA para diagnóstico de fiebre entérica por Salmonella spp.

    Directory of Open Access Journals (Sweden)

    Miryan Margot Sánchez

    2004-06-01

    Full Text Available El diagnóstico de fiebre entérica por Salmonella spp. se basa en el aislamiento de la bacteria en hemocultivos el cual consume tiempo, no siempre está disponible y tiene poca utilidad en pacientes con tratamiento antibiótico previo. Por consiguiente, se hace necesario el desarrollo de una prueba rápida, sensible y específica para el diagnóstico de fiebre entérica. Salmonella spp. utiliza el gen hilA (componente de la isla de patogenicidad I para invadir células epiteliales y producir infección. Al usar la secuencia de este gen se diseñó una prueba de PCR para detectar la bacteria en sangre y se evaluó su sensibilidad, especificidad, valor predictivo positivo y valor predictivo negativo, utilizando la metodología prueba de una prueba. La prueba de oro fue el hemocultivo. Se estudiaron 34 individuos con sintomatología de fiebre entérica con aislamiento de Salmonella serotipo Typhi en hemocultivos; 35 individuos con sepsis por otros bacilos Gram negativos aislados de hemocultivo (Klebsiella pneumoniae, 9; Serratia marcescens, 5; Escherichia coli, 4; Pseudomonas aeruginosa, 9; Providencia alcalifaciens, 4, y Enterobacter cloacae, 4 y 150 muestras de sangre de voluntarios asintomáticos. La sensibilidad, especificidad, valor pronóstico positivo y valor pronóstico negativo de la PCR fue del 100%. El número mínimo de UFC/ml que la PCR detecta en sangre es de 10.

  11. Dengue, Zika y Chikungunya

    OpenAIRE

    Kantor, Isabel N

    2016-01-01

    Los responsables de la actual pandemia de Chikungunya (alfavirus), dengue y Zika (flavivirus) son virus trasmitidos por artrópodos, arbovirus. Su importancia aumentó en las Américas en los últimos 20 años. Los vectores principales son Aedes aegypti y A. albopictus. La infección por dengue provee inmunidad duradera al serotipo específico y temporaria a otros tres. La posterior infección por otro serotipo determina mayor gravedad. Existe una vacuna contra dengue registrada, Dengvaxia (Sanofi Pa...

  12. COMPROMISO DE GANGLIOS BASALES EN DENGUE HEMORRÁGICO

    Directory of Open Access Journals (Sweden)

    Camilo Cortés Mora

    2016-11-01

    Full Text Available

    El dengue es una infección viral sistémica transmitida a los humanos por la hembra del mosquito Aedes aegypti. Alrededor del 10% de los pacientes con dengue pueden presentar alteraciones neurológicas durante o después de la infección. Existen unos signos conocidos como signos de alarma, los cuales, asociados al antecedente epidemiológico (procedencia de zona endémica, pueden ayudar a sospechar la infección. A continuación, se presentan algunas generalidades sobre el virus, las formas clínicas, las complicaciones y el análisis de una revisión sistemática de 65 historias clínicas de pacientes con diagnóstico de dengue o dengue hemorrágico. A partir de ellos, se encontró que se evidenciaron signos y síntomas neurológicos en 4 de los 39 casos que cumplieron los criterios de inclusión. Esta revisión permitió detectar un caso de hemorragia en la cabeza del núcleo caudado, asociada a la trombocitopenia marcada, inducida por el virus del dengue.

    BASAL GANGLIA INVOLVEMENT IN DENGUE HEMORRHAGIC FEVER (DHF

    ABSTRACT

    Dengue fever is a systemic viral infection transmitted to humans by the female Aedes aegypti mosquito. About 10% of patients with dengue fever may develop neurological disorders during or after infection. There are some signs known as warning signs, which, associated to the epidemiological background (origin of endemic area, may help to suspect the infection in those patients from endemic areas. Here are some generalities of the virus, its clinical forms, complications and the analysis of a systematic review of 65 clinical records of patients diagnosed with dengue and / or dengue hemorrhagic fever. From these patients, it was found that neurological signs and symptoms were evident in 4 of the 39 cases that fulfilled inclusion criteria. This review allowed to detect a case of hemorrhage in the head of the Caudate Nucleus associated with thrombocytopenia, induced by

  13. Dengue: a reappraisal

    OpenAIRE

    Serufo, José Carlos; Nobre, Vandack; Rayes, Abdunnabi; Marcial, Tânia Maria; Lambertucci, José Roberto

    2000-01-01

    Os conceitos de dengue clássico, com ou sem hemorragia, e de febre hemorrágica do dengue (FHD) que, pode cursar sem fenômenos hemorrágicos, com ou sem síndrome do choque do dengue (SCD), são revistos neste artigo. As definições clássicas propostas, úteis em outros tempos, geram confusão e dificultam a tomada de decisões no momento do tratamento dos pacientes com as formas graves da doença porque deixaram de incorporar novos conceitos e avanços terapêuticos. A classificação do dengue proposta ...

  14. Prophylactic platelets in dengue

    DEFF Research Database (Denmark)

    Whitehorn, James; Rodriguez Roche, Rosmari; Guzman, Maria G

    2012-01-01

    Dengue is the most important arboviral infection of humans. Thrombocytopenia is frequently observed in the course of infection and haemorrhage may occur in severe disease. The degree of thrombocytopenia correlates with the severity of infection, and may contribute to the risk of haemorrhage...... of platelets in dengue. Respondents were all physicians involved with the treatment of patients with dengue. Respondents were asked that their answers reflected what they would do if they were the treating physician. We received responses from 306 physicians from 20 different countries. The heterogeneity...... of the responses highlights the variation in clinical practice and lack of an evidence base in this area and underscores the importance of prospective clinical trials to address this key question in the clinical management of patients with dengue....

  15. Treatment of dengue fever

    OpenAIRE

    Rajapakse, Senaka; Rodrigo,Chaturaka; Rajapakse,Anoja Chamarie

    2012-01-01

    Senaka Rajapakse,1,2 Chaturaka Rodrigo,1 Anoja Rajapakse31Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Sri Lanka; 2Lincoln County Hospital, United Lincolnshire NHS Trust, Lincoln, UK; 3Kings Mill Hospital, Sherwood Forest NHS Foundation Trust, Mansfield, UKAbstract: The endemic area for dengue fever extends over 60 countries, and approximately 2.5 billion people are at risk of infection. The incidence of dengue has multiplied many times over the last five decad...

  16. El abordaje médico del dengue y la emergencia epidémica del chikungunya / Dengue’s Medical Approach and Chikungunya’s Epidemical Emergency / O tratamento clínico da dengue e o chikungunya como emergência epidêmica

    Directory of Open Access Journals (Sweden)

    Yinna Leonor Urquiza-Suárez, MD

    2015-03-01

    Full Text Available Sra. Editora: El dengue como enfermedad viral de afectación exclusiva de áreas tropicales, actualmente endémica en nuestro país, representa una de las principales causas de morbimortalidad por causa de enfermedades transmitidas por vectores (1, su control depende de una articulación intersectorial que actualmente ha sido difícil de implementar, fundamentada en el manejo entomológico y el control ambiental de humedales (2,3. En el país es una enfermedad de interés en salud pública, lo que obliga al personal asistencial en salud a conocer detalladamente el perfil fisiopatológico de la enfermedad (4. La fiebre de chikungunya ha sido una enfermedad endémica en algunos países tropicales latinoamericanos desde la segunda mitad del siglo XX, extendiéndose progresivamente a otras regiones con las condiciones adecuadas de transmisión vectorial (5. De esta manera, esta carta al editor tiene como finalidad motivar a los médicos para estar dispuestos a una educación continua que permita tener claridad sobre el perfil clínico de cada una de estas enfermedades. Recientemente en Colombia se ha reportado una emergencia en la transmisión del dengue y chinkungunya, lo que ha obligado a las autoridades en salud pública a despertar las alarmas para su abordaje y vigilancia (6. Las estrategias de intervención incluyen un control entomológico y la notificación periódica de los casos detectados por el perfil clínico de la enfermedad (7. Actualmente se llevan a cabo en el país múltiples jornadas de capacitación del personal asistencial sanitario, en especial en las ciudades de ambientes cálidos donde se han reportado la mayor cantidad de casos. El fenómeno relacionado con la emergencia epidémica de la enfermedad de transmisión vectorial ha generado alerta en todo el gremio de la salud e irónicamente se ha sobrevalorado la notificación de la enfermedad (8. Esto ha repercutido en el perfil diagnóstico del dengue con un efecto cr

  17. Estado actual de la bartonellosis (fiebre verrucosa. verruga en el continente americano

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    Luis Patiño Camargo

    1940-09-01

    Full Text Available Trabajo Presentado al VIII Congreso Científico Panamericano reunido en Washington D.C. en mayo de 1940 por La grave calamidad que ha constituido para Colombia la epidemia de Bartonellosis o Fiebre Verrucosa en una región septentrional de su territorio; la endemia legendaria de el Perú; el hecho de haberse señalado en los últimos días focos activos en el Ecuador; y la circunstancia verosímil de que las remotas epidemias llamadas "Bubas" en Guatemala hayan sido de Verruga, demuestran que sobre un dilatado territorio, en varias naciones tributarias del Pacífico existen focos de Bartonellosis en el Continente Americano.

  18. Treatment of dengue fever

    Directory of Open Access Journals (Sweden)

    Rajapakse S

    2012-07-01

    Full Text Available Senaka Rajapakse,1,2 Chaturaka Rodrigo,1 Anoja Rajapakse31Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Sri Lanka; 2Lincoln County Hospital, United Lincolnshire NHS Trust, Lincoln, UK; 3Kings Mill Hospital, Sherwood Forest NHS Foundation Trust, Mansfield, UKAbstract: The endemic area for dengue fever extends over 60 countries, and approximately 2.5 billion people are at risk of infection. The incidence of dengue has multiplied many times over the last five decades at an alarming rate. In the endemic areas, waves of infection occur in epidemics, with thousands of individuals affected, creating a huge burden on the limited resources of a country's health care system. While the illness passes off as a simple febrile episode in many, a few have a severe illness marked by hypovolemic shock and bleeding. Iatrogenic fluid overload in the management may further complicate the picture. In this severe form dengue can be fatal. Tackling the burden of dengue is impeded by several issues, including a lack of understanding about the exact pathophysiology of the infection, inability to successfully control the vector population, lack of specific therapy against the virus, and the technical difficulties in developing a vaccine. This review provides an overview on the epidemiology, natural history, management strategies, and future directions for research on dengue, including the potential for development of a vaccine.Keywords: dengue, treatment, fluid resuscitation

  19. Dengue virus infection down-regulates differentiation markers in neuroblastoma cells

    OpenAIRE

    Rincón Forero, Verónica; Alvear Gómez, Diana; Solano Orjuela, Oscar; Prada-Arismendy, Jeanette; Castellanos Parra, Jaime Eduardo

    2011-01-01

    Introducción: cerca del 5% de los pacientes con dengue hemorrágico pueden presentar manifestaciones neurológicas; sin embargo, existe poca información sobre la infección directa por el virus dengue (DENV) en neuronas. Objetivo: determinar el papel del fenotipo neuronal en la infección por DENV en células de neuroblastoma SH-SY5Y inducidas o no a la diferenciación con ácido retinoico (AR). Materiales y métodos: células SH-SY5Y fueron inducidas con AR a diferenciarse e infectadas con DENV. Post...

  20. Entre la fiebre del oro y el polvo de las voladuras… Cuerpos y emociones en contextos de mineralización.

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    Horacio Machado Aráoz

    2013-04-01

    Full Text Available A partir de la constatación de las grandes transformaciones sociales provocadas por el desembarco de la megaminería transnacional en la Provincia de Catamarca, el presente trabajo se plantea abordar el análisis de la conflictividad ‘minera’ desde la perspectiva de sus impactos microbiopolíticos, esto es, en el plano de los cuerpos, las emociones y los sentimientos. Considerando que se trata de un aspecto crucial de los procesos sociales que se verifican en los nuevos escenarios del extractivismo minero, este trabajo procura desarrollar una ecología política de las emociones como clave para caracterizar los conflictos mineros, así como los efectos eco-biopolíticos que se producen en las comunidades locales intervenidas. Apelando a registros etnográficos, se exponen diferentes dimensiones de los cambios sociales resultantes de las políticas mineras sobre los cuerpos y las emociones. Con los conceptos de fiebre del oro y mineralización social, se busca brindar una hermenéutica crítica de estos procesos orientada a visibilizar lo que se entiende como sus rasgos y efectos neocoloniales.

  1. Dengue en el embarazo: efectos en el feto y el recién nacido.

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    Berta N. Restrepo

    2003-12-01

    Full Text Available El riesgo de infección por el virus del dengue durante el embarazo se está incrementando ante mayores y más severas epidemias, y las consecuencias sobre el feto y el recién nacido han sido poco estudiadas y, en otros casos, los resultados han sido contradictorios. Por esta razón, se realizó en Medellín un estudio de cohorte retrospectiva, cuyo objetivo fue determinar los efectos que produce el dengue durante el embarazo sobre el feto y el recién nacido. En dicho estudio se evaluaron 22 recién nacidos hijos de mujeres que presentaron dengue durante la epidemia de 1998 y se compararon con 24 recién nacidos, hijos de mujeres embarazadas sin dengue. En la cohorte con dengue se encontraron 3 niños prematuros, 3 niños con sufrimiento fetal y 4 niños con bajo peso al nacer. En la cohorte no expuesta no se encontraron niños con estos problemas. El desarrollo psicomotor fue normal en ambos grupos. De las observaciones anteriores, sólo fue estadísticamente significativa la frecuencia de niños con bajo peso al nacer (prueba exacta de Fisher, p=0,045. Estos resultados preliminares muestran que los recién nacidos de madres que sufrieron dengue durante la gestación tuvieron riesgo de bajo peso al nacer y presentaron con mayor frecuencia prematurez y sufrimiento fetal, aunque se requiere aumentar el tamaño de la muestra para confirmar estos resultados. Sin embargo, es necesario estrechar la vigilancia a las madres embarazadas con dengue dados los efectos nocivos sobre la evolución del recién nacido.

  2. Aspectos del dengue investigados en Santander

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    Ruth Martínez

    2004-03-01

    Full Text Available

    Entre 1998 y 2003 se registraron en Colombia 256,831 casos de dengue (22,834 de dengue hemorrágico DH de los cuales 41,325 (36% fueron en Santander (3,265 DH (1,2. En este período ocurrieron brotes en 1998 y 2001 observándose incremento de casos severos en el segundo (2. Por otro lado, existen inconvenientes con el diagnóstico que dificultan el manejo clínico oportuno y la vigilancia epidemiológica. Como consecuencia, los siguientes aspectos han sido investigados:

    1 Contribución de la circulación de los serotipos/genotipos al incremento del dengue hemorrágico, considerando que la entrada o emergencia de éstos se han asociado con epidemias (3. Entre 1998 y 2004 se hicieron 1,180 intentos de aislamiento viral en células C6/36 (4, detectándose los 4 serotipos. El DEN-2 se aisló todos los años con mayor frecuencia durante los brotes (43% y 40% de los cepas; el DEN-1 se detectó entre 1998 y 2001, siendo el prevalente en el primer brote (57%, pero el menos en el segundo (4%; el DEN-3 se detectó en el brote del 2001 con similar frecuencia al DEN-2 (36%, por primera vez en Colombia luego de 23 años ausente, y fue el prevalerte entre 2002-2004 (92% de los aislados, aunque en estos años no se reportó incremento del DH (2; el DEN-4 se aisló solo en el 2000 (27% y en el brote del 2001 (20%. El genotipo de cada serotipo se identificó por análisis de RSS-PCR (5,6. Se encontraron el subtipo A (ó III, C (ó I y B (ó II de los serotipos 2, 1 y 4, similares a los que están circulando en países de América y oriundos del Asia. Los DEN-3 fueron del subtipo C (ó III iguales al virus que entró en América en 1994 oriundo de Sri-Lanka, India. Los genotipos del 2 y 3 encontrados en Santander producen con mayor frecuencia DH (3,7.

    Dengue en México: incremento en la población juvenil durante la última década

    OpenAIRE

    Torres-Galicia, Ivonne; Cortés-Poza, David; Becker, Ingeborg

    2014-01-01

    El dengue es una de las principales enfermedades transmitidas por vector. En la última década se convirtió en uno de los problemas de salud pública más importantes de México y América Latina. En el continente americano el dengue es considerado predominantemente un padecimiento de adultos, lo cual contrasta con los reportes de países asiáticos que consideran el dengue como una enfermedad principalmente pediátrica. Durante la última década se ha reportado el incremento de dengue juvenil y pediá...

  3. Estudio prospectivo de la cefalea en pacientes con hemopatías malignas

    OpenAIRE

    Marín Lahoz, Juan

    2013-01-01

    Objetivo: describir las cefaleas en pacientes ingresados con neoplasias hematológicas, identificar los factores asociados a cefaleas secundarias graves. Estudio observacional prospectivo. Se incluyen 30 casos de cefalea correspondientes a 23 pacientes. Ocho cefaleas son primarias y 22 secundarias. Diez de estas, son secundarias a patología grave o potencialmente grave: encefalopatía hipertensiva, neoplasia intracraneal, hemorragia intracraneal, infección cefálica, trombosis venosa, fiebre tum...

  4. Médicos y policías durante la epidemia de fiebre amarilla (Buenos Aires, 1871

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    Diego Galeano

    2009-01-01

    Full Text Available Este trabajo analiza la actuación de médicos y policías durante la epidemia de fiebre amarilla que tuvo lugar en la ciudad de Buenos Aires en 1871. Aunque las embestidas de enfermedades infectocontagiosas fueron recurrentes durante el siglo XIX, la epidemia de fiebre amarilla constituye un quiebre, no solo por sus dimensiones cuantitativas y por los efectos materiales sobre la ciudad, sino también por las querellas que suscitó entre discursos en pugna. En particular, se intenta mostrar aquí cómo las figuras de los médicos y los policías fueron posicionadas en relación al tema del héroe y del sacrificado en cumplimiento del deber.

  5. THROMBOCYTOPENIA IN DENGUE HAEMORRHAGIC FEVER

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    I Wayan Putu Sutirta-Yasa

    2013-04-01

    Full Text Available The incidence and geographical distribution of dengue has gradually increased during the past decade. Today, dengue is considered one of the most important arthropod-borne viral diseasases in humans in term of morbidity and mortality. Dengue infection   a potential life-threatening dengue hemorrhagic fever (DHF / dengue shock syndrome(DSS, characterized by thrombocytopenia and increased vascular permiability. Thrombocytopenia causes bleeding, but in   DHF patients with thrombocytopenia do not always develop bleeding manifestation. The pathogenesis of thrombocytopenia are not cleared. Multiple factors  may be involved in the machanisms leading to thrombocytopenia in DHF/DSS patients.

  6. Neurological Manifestations of Dengue Infection

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    Guo-Hong Li

    2017-10-01

    Full Text Available Dengue counts among the most commonly encountered arboviral diseases, representing the fastest spreading tropical illness in the world. It is prevalent in 128 countries, and each year >2.5 billion people are at risk of dengue virus infection worldwide. Neurological signs of dengue infection are increasingly reported. In this review, the main neurological complications of dengue virus infection, such as central nervous system (CNS, peripheral nervous system, and ophthalmic complications were discussed according to clinical features, treatment and possible pathogenesis. In addition, neurological complications in children were assessed due to their atypical clinical features. Finally, dengue infection and Japanese encephalitis were compared for pathogenesis and main clinical manifestations.

  7. Seroprevalence of dengue virus antibodies in asymptomatic Costa Rican children, 2002-2003: a pilot study La seroprevalencia de anticuerpos contra el virus del dengue en niños costarricenses asintomáticos, 2002-2003: estudio piloto

    Directory of Open Access Journals (Sweden)

    Roberto Iturrino-Monge

    2006-07-01

    epidemiológico descriptivo y prospectivo se comparó la presencia de anticuerpos en niños que vivían en la zona costera de un país tropical donde el dengue es endémico, y en una zona del interior donde no lo es. Se usó inmunoadsorción enzimática para detectar IgG en el suero. Ninguno de los niños tenía antecedentes de dengue, enfermedad febril, tratamiento inmunosupresor o enfermedad subyacente. RESULTADOS: Durante el período transcurrido desde julio de 2003 hasta julio de 2003, se reunió a 103 niños de cada área. En la zona costera encontramos una seroprevalencia de IgG de 36,9%; en el interior, de 2,9%. CONCLUSIONES: Encontramos muchos casos de infección asintomática por el virus del dengue en niños costarricenses. Esto conlleva un riesgo elevado de fiebre hemorrágica del dengue o de síndrome de choque por dengue en estos niños en quienes la infección había pasado inadvertida. Es necesario tomar medidas preventivas en la región del litoral debido a la mayor prevalencia de la enfermedad en ella.

  8. OCTOGESIMO ANIVERSARIO DEL DESCUBRIMIENTO DE LA FIEBRE AMARILLA SELVÁTICA POR EL DOCTOR ROBERTO FRANCO

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    Carlos Sanmartín Barberi

    1989-09-01

    Full Text Available

    La reunión que hoy nos congrega en esta sesión conjunta tiene por objeto conmemorar una importante efemérides de la medicina universal y tributar homenaje a la memoria de un excepcional galeno de nuestra patria.

    Me permitiré leer una breve comunicación que el 8 de octubre del año pasado dirigí al Presidente de nuestra Academia, pues resume el motivo central de esta ceremonia:
    “El año próximo venidero se cumplen ochenta de la trascendental comunicación del Dr. Roberto Franco sobre una epidemia febril que estudió en las Minas de Muzo.
    Tal investigación constituye uno de los hitos más importantes de la medicina tropical. Las novedosas conclusiones del Dr. Franco, basadas en un juicioso estudio de campo y en una sagaz observación clínica y epidemiológica, fueron puestas en duda y aún negadas en su época. Sólo el tiempo y las investigaciones posteriores dieron razón a su notable afirmación de la existencia de la fiebre amarilla de los bosques.

    Me parece que sería justo y oportuno que la Academia celebre tal aniversario de manera apropiada y que se aproveche la ocasión para exaltar la memoria del que fue, sin duda, una de las figuras cimeras de la medicina nacional”.
    Tanto la Academia como nuestra Sociedad histórica, a las que me honro en pertenecer, acogieron favorablemente la sugerencia. Me enaltece sobremanera ser yo quien esta noche las representa.

    En el número 331 de Noviembre de 1907 de la Revista Médica de Bogotá, órgano de la Academia Nacional de Medicina, se publicó el informe presentado al Presidente del Sindicato de las Minas de Muzo, por la misión encargada de estudiar la epidemia de fiebres observada en la mina en los meses de Marzo y Abril de 1907. Tal documento tiene fecha del 14 de Mayo del mismo año y está suscrito por el Dr. Roberto Franco, quien deja constancia de la invaluable colaboración de dos de sus estudiantes que le acompañaron a Muzo y que fueron los

  9. A mortality study of the last outbreak of yellow fever in Barcelona City (Spain in 1870 Estudio de la mortalidad del último brote de fiebre amarilla en la ciudad de Barcelona (España en 1870

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    Jaume Canela Soler

    2009-08-01

    Full Text Available Background: The last outbreak of yellow fever in the city of Barcelona, Spain, was caused by a ship arriving from Cuba. The objective of this study was to describe and analyze the epidemic of 1870 by using the available mortality data. Methods: The information on 1,235 deaths identified in the parochial registries was analyzed, using statistical and epidemiological procedures for epidemic outbreaks. Results: Mortality due to yellow fever was 549.7 per 100,000 inhabitants. The temporal distribution of the deaths showed two peaks at the end of September and October with the last fatalities occurring in December 1870. The distribution of the fatalities in the city's neighborhoods was unequal. In La Barceloneta, in particular, more fatalities were found in the streets adjacent to the port than in the most remote streets (r=0.83; pObjetivo: El último brote de fiebre amarilla en la ciudad de Barcelona, España, se originó a partir de un barco que venía de Cuba. El objetivo de este estudio es describir y analizar esa epidemia ocurrida en 1870, utilizando los datos disponibles de mortalidad. Métodos: La información de las 1235 defunciones identificadas en los registros parroquiales se ha analizado utilizando los procedimientos estadísticos y epidemiológicos para brotes epidémicos. Resultados: La tasa de mortalidad por fiebre amarilla fue de 549.7 por 100,000 habitantes. La distribución temporal de las muertes tenía dos modas en el final de septiembre y octubre, y los últimos muertos ocurrieron en diciembre de 1870. La distribución de las defunciones según los barrios de la ciudad fue desigual. En La Barceloneta, en particular, hubo mas muertos en las calles adyacentes al puerto que en las más lejanas (r=0,83; p<0,0001. Conclusiones: Este estudio muestra una distribución bimodal de la mortalidad por fiebre amarilla durante el brote, con un impacto alto en hombres adultos, y en el barrio de La Barceloneta.

  10. Significado de la fiebre persistente o recurrente durante el tratamiento de la endocarditis infecciosa Clinical significance of persistent or recurrent fever during the treatment of infective endocarditis

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    José Carena

    2004-06-01

    Full Text Available Se evaluaron 81 pacientes con endocarditis infecciosa con el objeto de establecer la significación clínica de la presencia de fiebre persistente (FP y/o fiebre recurrente (FR durante el tratamiento. Un total de 46 pacientes (56.8% (Grupo 1 tuvieron FP y/o FR durante el tratamiento: 35 FP y 16 FR, que se compararon con 35 sin FP/FR (Grupo 2. No hubo diferencias en la edad, sexo, permanencia hospitalaria, origen nosocomial, demora diagnóstica y comorbilidad asociada. El compromiso aórtico (47.8 vs 34.2% y tricuspídeo (21.7 vs 11.4% y la infección por Staphylococcus aureus (55.5 vs 28% fueron más frecuentes en el Grupo 1, aunque no significativamente. El S. aureus meticilino resistente (SAMR (22.2 vs 4%, las complicaciones (95.6 vs 65.7%, la disfunción renal (58.6 vs 31.4%, el embolismo mayor (60.8 vs 34%, los fenómenos microvasculares (43.4 vs 17.1% y la cirugía valvular (34.7 vs 11.4% ocurrieron significativamente en el Grupo 1 (pPatients with infective endocarditis (IE were studied to assess incidence, clinical features and mortality in a population with either persistent (PF or recurrent fever (RF during treatment. A sample of 81 patients was evaluated. Of these, 46 patients (56.8% had fever during treatment: 35 had PF and 16 had RF (Group 1. This group was compared with 35 patients with IE without fever (Group 2. Age, sex, in-hospital days, nosocomial acquisition, delay in diagnosis, and co-morbidities were similar among each group. The aortic and tricuspid valve compromise, and Staphylococcus aureus as etiologic agent were more frequent in Group 1 (although not significantly. However, the development of complications (95.6 vs. 65.7%, renal dysfunction (58.6 vs. 31.4%, major vessel embolization (60.8 vs. 34%, microvascular phenomena (43.4 vs. 17.1%, infections with MRSA (22.2 vs. 4% and valvular surgery (34.7 vs. 11.4% were significantly higher in Group 1(p<0.05. The most common causes of PF were microvascular phenomena (14

  11. Introducing dengue vaccine: Implications for diagnosis in dengue vaccinated subjects.

    Science.gov (United States)

    Alagarasu, Kalichamy

    2016-05-27

    Diagnosis of dengue virus infections is complicated by preference for different diagnostic tests in different post onset days of illness and the presence of multiple serotypes leading to secondary and tertiary infections. The sensitivity of the most commonly employed diagnostic assays such as anti dengue IgM capture (MAC) ELISA and non structural protein (NS) 1 capture ELISA are lower in secondary and subsequent infections. Introduction of dengue vaccine in endemic regions will affect the way how dengue is diagnosed in vaccinated subjects. This viewpoint article discusses implications of introduction of dengue vaccine on the diagnosis of dengue infections in vaccinated subjects and the strategies that are needed to tackle the issue. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. Autoridad e imagen de la epidemia. La fiebre amarillean la Barcelona del siglo XIX

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    José Antonio Ortiz García

    2017-12-01

    Full Text Available El propósito de este estudio es acercarse al contexto epidémico de Barcelona a lo largo del siglo XIX. De forma concreta, la investigación se centra en la fiebre amarilla sufrida en los años 1821 y 1870. El amplio abanico de referencias propone una mirada interdisciplinar sobre la medicina y las enfermedades en su marco histórico, artístico, social y religioso. ¿Qué reacción tuvieron los poderes municipales?, ¿Qué tipologías artísticas se desarrollaron durante y tras la infección deletérea en Barcelona? The aim of this study is an approach to the epidemic background in Barcelona during the XIX century. Specifically, the research is focus on the yellow fever that was suffered en 1821 and 1870. e large spectrum of references proposes an interdisciplinary point of view about medicine and illnesses in an historic, artistic, social and religious context. How was the official reaction of the municipal powers? What kind of artistic productions were made during and after de epidemic infection in Barcelona?

  13. Bartonelosis (Fiebre de la Oroya o Verruga Peruana: ¿Enfermedad ocupacional?

    Directory of Open Access Journals (Sweden)

    R. Cesar Gonzáles

    Full Text Available La Bartonella bacilliformis es un parásito bacteriano intracelular facultativo de los eritrocitos humanos y de las células endoteliales. La enfermedad de Carrión, fiebre de La Oroya y Verruga Peruana son todos términos que describen las consecuencias patológicas de la infección humana por Bartonella bacilliformis. (1 Aunque las infecciones que involucran especies de Bartonella, tales como Bartonella henselae y Bartonella quintana, ocurren en todo el mundo, la enfermedad de Carrión es endémica únicamente en Sudamérica. (14 Las infecciones por B. bacilliformis son un problema de salud en numerosas áreas rurales de Sudamérica y para los viajeros que visitan esas regiones. Se han reportado brotes de bartonelosis en las regiones montañosas de Perú, Ecuador y Colombia. (1 La Lutzomyia verrucarum es el principal vector para la transmisión de la bacteria al ser humano; la hembra del mosquito transmite el patógeno durante su alimentación nocturna de sangre humana. Presumiblemente el insecto se alimenta de sangre de un individuo infectado y disemina el patógeno por medio de su saliva durante la siguiente ingesta de sangre. La bacteria no es contagiosa entre humanos. (1 Presentamos un enfoque laboral de la enfermedad en trabajadores que realizan desplazamientos continuos a zonas endémicas y analizamos sus posibles consecuencias.

  14. [Dengue, Zika and Chikungunya].

    Science.gov (United States)

    Kantor, Isabel N

    2016-01-01

    Arboviruses are transmitted by arthropods, including those responsible for the current pandemic: alphavirus (Chikungunya) and flaviviruses (dengue and Zika). Its importance increased in the Americas over the past 20 years. The main vectors are Aedes aegypti and A. albopictus. Dengue infection provides long lasting immunity against the specific serotype and temporary to the other three. Subsequent infection by another serotype determines more serious disease. There is a registered vaccine for dengue, Dengvaxia (Sanofi Pasteur). Other two (Butantan and Takeda) are in Phase III in 2016. Zika infection is usually asymptomatic or occurs with rash, conjunctivitis and not very high fever. There is no vaccine or specific treatment. It can be transmitted by parental, sexual and via blood transfusion. It has been associated with microcephaly. Chikungunya causes prolonged joint pain and persistent immune response. Two candidate vaccines are in Phase II. Dengue direct diagnosis is performed by virus isolation, RT-PCR and ELISA for NS1 antigen detection; indirect methods are ELISA-IgM (cross-reacting with other flavivirus), MAC-ELISA, and plaque neutralization. Zika is diagnosed by RT-PCR and virus isolation. Serological diagnosis cross-reacts with other flavivirus. For CHIKV culture, RT-PCR, MAC-ELISA and plaque neutralization are used. Against Aedes organophosphate larvicides (temephos), organophosphorus insecticides (malathion and fenitrothion) and pyrethroids (permethrin and deltamethrin) are usually employed. Resistance has been described to all these products. Vegetable derivatives are less expensive and biodegradable, including citronella oil, which microencapsulated can be preserved from evaporation.

  15. Dengue Fever Treatment

    Science.gov (United States)

    ... AIDS Influenza Malaria Respiratory Syncytial Virus (RSV) Tuberculosis Zika Virus Find a Funding Opportunity Opportunities & Announcements Types of ... For example, the entire genome sequence of the Aedes aegypti mosquito, the main carrier of dengue virus, has been decoded and is available to qualified ...

  16. Dengue fever and dengue haemorrhagic fever in adolescents and adults

    OpenAIRE

    Tantawichien, Terapong

    2012-01-01

    Dengue fever (DF) is endemic in tropical and subtropical zones and the prevalence is increasing across South-east Asia, Africa, the Western Pacific and the Americas. In recent years, the spread of unplanned urbanisation, with associated substandard housing, overcrowding and deterioration in water, sewage and waste management systems, has created ideal conditions for increased transmission of the dengue virus in tropical urban centres. While dengue infection has traditionally been considered a...

  17. Dengue fever: diagnosis and treatment.

    Science.gov (United States)

    Wiwanitkit, Viroj

    2010-07-01

    Dengue fever is a common tropical infection. This acute febrile illness can be a deadly infection in cases of severe manifestation, causing dengue hemorrhagic shock. In this brief article, I will summarize and discuss the diagnosis and treatment of this disease. For diagnosis of dengue, most tropical doctors make use of presumptive diagnosis; however, the definite diagnosis should be based on immunodiagnosis or viral study. Focusing on treatment, symptomatic and supportive treatment is the main therapeutic approach. The role of antiviral drugs in the treatment of dengue fever has been limited, but is currently widely studied.

  18. Manifestaciones clínicas y complicaciones de la fase aguda de bartonelosis o Fiebre de la Oroya en pacientes atendidos en el Hospital Nacional Cayetano Heredia.

    Directory of Open Access Journals (Sweden)

    Ciro Peregrino Maguiña Vargas

    2008-07-01

    Full Text Available Objetivos: Determinar las características clínicas, epidemiológicas y de laboratorio de la bartonelosis aguda, así como las complicaciones en una serie de pacientes atendidos en el Hospital Nacional Cayetano Heredia. Material y métodos: Estudio descriptivo de tipo serie de casos de pacientes mayores de 15 años con bartonelosis aguda hospitalizados en el Hospital Nacional Cayetano Heredia entre 1993 y 2006. Resultados: La edad promedio fue 27,8 años, 72,7% fueron varones, 51,5% procedía de Lima y 33,3% de Ancash. Los síntomas principales fueron: fiebre 90,9%, cefalea 87,9%, hiporexia 75,5%, baja de peso 63,6%, e ictericia 57,6%. Dos pacientes presentaron alteraciones en el fondo de ojo: retinitis exudativa y retinopatía hemorrágica. El hematocrito promedio fue 20,8% y 63,6% cursaron hematocrito £20%. Hubo desviación izquierda en 24,2%, hiperbilirrubinemia a predominio indirecto 62,5% e hipoalbuminemia (< 3mg/dl 56,5%. Se presentaron complicaciones en 84,8%, el 27,2% requirió internamiento en UCI. Las complicaciones no infecciosas ocurrieron en 84,8%, hematológicas 81,8% y gastrointestinales 78,7%. Las complicaciones infecciosas se presentaron en 12,1%. Los antibióticos más utilizados fueron ciprofloxacina 66,6% y cloranfenicol 42,4%, se administró corticoides en 9,1% y se transfundió paquete globular en 42,4%. Conclusiones: Los pacientes de UCI tuvieron más complicaciones cardiovasculares, trombocitopenia y mayor severidad de la anemia. No se registró mortalidad. (Rev. Med Hered 2008;19:87-95

  19. Una rareza bibliográfica escrita en Cuba sobre fiebre amarilla A bibliography rarity on yelow fever written in Cuba

    Directory of Open Access Journals (Sweden)

    José Antonio López Espinosa

    2004-12-01

    Full Text Available Se brinda una síntesis biográfica del cirujano de origen escosés John Holliday Heragod (Juan Tomás José Agustín Domínguez, quien fue el autor de una de las primeras obras escritas en Cuba sobre la fiebre amarilla, y se ofrecen algunas observaciones en relación con el proceso de convalidación de su título ante el Real Tribunal del Protomedicato de La Habana. Se emiten varias consideraciones referentes a las circunstancias que rodearon la redacción en español del citado documento en 1794, su presentación en la Real Sociedad Patriótica de Amigos del País en 1796 y su publicación en inglés fuera de Cuba el mismo año, como elementos para ubicarlo en el lugar adecuado en el contexto de la historia de la bibliografía médica cubanaA brief bibliography on the Scoth surgeon John Holliday Heragod (Juan Tomás José Agustín Domínguez is given. Dr. Heragod was one of the first authors who wrote about the yellow fever in Cuba. Some observations are made concerning the process for validating his diploma at the Real Tribunal del Protomedicato de la Habana. Some considerations are made referring the Spanish equivalent of the document in 1794, its presentation at the Real Sociedad Patriótica Amigos del País in 1794, and its publication in the English languaje outside Cuba in the same year, as well as its palce in the history of the Cuban bibliography on Medicine

  1. Overview of current situation of dengue and dengue vector control

    Science.gov (United States)

    Dengue is the most important arbovirus of humans in the world. It is caused by one of four closely related virus serotypes whose primary vector is Aedes aegypti and secondarily by Ae. albopictus. A global dengue pandemic began in Southeast Asia after World War II and has intensified during the las...

  2. Ensemble method for dengue prediction.

    Science.gov (United States)

    Buczak, Anna L; Baugher, Benjamin; Moniz, Linda J; Bagley, Thomas; Babin, Steven M; Guven, Erhan

    2018-01-01

    In the 2015 NOAA Dengue Challenge, participants made three dengue target predictions for two locations (Iquitos, Peru, and San Juan, Puerto Rico) during four dengue seasons: 1) peak height (i.e., maximum weekly number of cases during a transmission season; 2) peak week (i.e., week in which the maximum weekly number of cases occurred); and 3) total number of cases reported during a transmission season. A dengue transmission season is the 12-month period commencing with the location-specific, historical week with the lowest number of cases. At the beginning of the Dengue Challenge, participants were provided with the same input data for developing the models, with the prediction testing data provided at a later date. Our approach used ensemble models created by combining three disparate types of component models: 1) two-dimensional Method of Analogues models incorporating both dengue and climate data; 2) additive seasonal Holt-Winters models with and without wavelet smoothing; and 3) simple historical models. Of the individual component models created, those with the best performance on the prior four years of data were incorporated into the ensemble models. There were separate ensembles for predicting each of the three targets at each of the two locations. Our ensemble models scored higher for peak height and total dengue case counts reported in a transmission season for Iquitos than all other models submitted to the Dengue Challenge. However, the ensemble models did not do nearly as well when predicting the peak week. The Dengue Challenge organizers scored the dengue predictions of the Challenge participant groups. Our ensemble approach was the best in predicting the total number of dengue cases reported for transmission season and peak height for Iquitos, Peru.

  3. Ensemble method for dengue prediction.

    Directory of Open Access Journals (Sweden)

    Anna L Buczak

    Full Text Available In the 2015 NOAA Dengue Challenge, participants made three dengue target predictions for two locations (Iquitos, Peru, and San Juan, Puerto Rico during four dengue seasons: 1 peak height (i.e., maximum weekly number of cases during a transmission season; 2 peak week (i.e., week in which the maximum weekly number of cases occurred; and 3 total number of cases reported during a transmission season. A dengue transmission season is the 12-month period commencing with the location-specific, historical week with the lowest number of cases. At the beginning of the Dengue Challenge, participants were provided with the same input data for developing the models, with the prediction testing data provided at a later date.Our approach used ensemble models created by combining three disparate types of component models: 1 two-dimensional Method of Analogues models incorporating both dengue and climate data; 2 additive seasonal Holt-Winters models with and without wavelet smoothing; and 3 simple historical models. Of the individual component models created, those with the best performance on the prior four years of data were incorporated into the ensemble models. There were separate ensembles for predicting each of the three targets at each of the two locations.Our ensemble models scored higher for peak height and total dengue case counts reported in a transmission season for Iquitos than all other models submitted to the Dengue Challenge. However, the ensemble models did not do nearly as well when predicting the peak week.The Dengue Challenge organizers scored the dengue predictions of the Challenge participant groups. Our ensemble approach was the best in predicting the total number of dengue cases reported for transmission season and peak height for Iquitos, Peru.

  4. Dengue in the Americas and Southeast Asia: do they differ? El dengue en las Américas y el sudeste asiático: ¿son diferentes?

    Directory of Open Access Journals (Sweden)

    Scott B. Halstead

    2006-12-01

    las Américas ocurrieron 2,8 millones de casos de dengue, principalmente en adultos, y solo 65 000 casos de DH. El objetivo de esta revisión es explicar estas diferencias regionales. En el sudeste asiático, con la Segunda Guerra Mundial se extendieron las poblaciones del mosquito Aedes aegypti y se diseminó el virus del dengue. En las Américas, los esfuerzos para erradicar el A. aegypti en las décadas de 1940 y 1950 restringieron las epidemias de dengue principalmente a la cuenca del Caribe. Cuba escapó a las infecciones por el genotipo americano del dengue-2 y un endémico asiático del dengue-3 en las décadas de 1960 y 1970. Infecciones sucesivas con el virus del dengue-1 y un genotipo asiático del dengue-2 dio como resultado una epidemia de DH en 1981. Cuando este virus del dengue-2 se introdujo en otros países caribeños encontró poblaciones con un alto grado de inmunidad al genotipo americano del dengue-2. Durante las décadas de 1980 y 1990, la rápida expansión de las poblaciones de A. aegyti en Brasil favorecieron la aparición de epidemias sucesivas de dengue-1, dengue-2 y dengue-3. Estas, no obstante, provocaron principalmente casos de dengue con sorpresivamente pocos casos de DH. La ausencia de altas tasas de formas graves de dengue en Brasil y otros países de la Región puede explicarse en parte por la amplia presencia de genes humanos de resistencia al dengue. La comprensión de la naturaleza y de la distribución de estos genes crea grandes expectativas para frenar las formas graves de dengue. Las investigaciones futuras sobre la infección por los virus del dengue deben poner énfasis en diseños basados en la población.

  5. Micronutrients and Dengue

    OpenAIRE

    Ahmed, Sundus; Finkelstein, Julia L.; Stewart, Anna M.; Kenneth, John; Polhemus, Mark E.; Endy, Timothy P.; Cardenas, Washington; Mehta, Saurabh

    2014-01-01

    Dengue virus infection is the most widespread mosquito-borne viral infection in humans and has emerged as a serious global health challenge. In the absence of effective treatment and vaccine, host factors including nutritional status, which may alter disease progression, need investigation. The interplay between nutrition and other infections is well-established, and modulation of nutritional status often presents a simple low-cost method of interrupting transmission, reducing susceptibility,...

  6. Modificación de conocimientos sobre fiebre tifoidea en jóvenes en la comuna Morón, Haití Changes in knowledge of typhoid fever in young people: Commune of Moron, Haiti

    Directory of Open Access Journals (Sweden)

    Annia Dolores Gorte Quiñones

    2009-12-01

    Full Text Available La fiebre tifoidea es una enfermedad de alta incidencia en Haití. Se realizó un estudio del tipo de intervención educativa en la Comuna de Morón, Departamento de la Grand´Anse, República de Haití durante el período de enero a noviembre del 2006, con el objetivo de modificar y ampliar los conocimientos que poseen las personas de esta comunidad en relación con la fiebre tifoidea. De un universo de 523 jóvenes entre 15 y 35 años de edad se utilizó una muestra de 50 jóvenes mediante muestreo simple aleatorio, lo que representó el 9.56 por ciento del total. Para la obtención del dato primario, se aplicó un cuestionario antes y después del programa educativo, en el que se recogieron aspectos referentes al conocimiento teórico. El procesamiento estadístico utilizó el análisis de variables cualitativas, utilizando como medida de resumen la frecuencia relativa porcentual. Predominó el grupo de 20-25 años, así como el nivel secundario de escolaridad. Al finalizar el estudio la totalidad de los jóvenes reconoció la importancia de la asistencia al área de salud ante la presencia de síntomas de la enfermedad y demostraron conocimientos generales satisfactorios con respecto al tema. Se demuestra la eficacia de la intervención educativa.Typhoid fever is a high-incidence disease in Haiti. An educative intervention study was conducted in the Commune of Moron, de la Grand´Anse Department, Haiti Republic during January to November 2006 with the purpose of modifying and extending the knowledge of Typhoid Fever people of this community possessed. The universe included 523 young people (15-35 years old; 50 young people were taken as a simple random sample; which represented the 9, 56% of the total. To record the primary data, a questionnaire was applied before and after the educative program, where aspects of the theoretical knowledge were collected. The statistical process was carried out analyzing qualitative variables, using as a

  7. Impacto económico del dengue y del dengue hemorrágico en el Estado de Zulia, Venezuela, 1997-2003 Economic impact of dengue and dengue hemorrhagic fever in the State of Zulia, Venezuela, 1997-2003

    Directory of Open Access Journals (Sweden)

    Germán Añez

    2006-05-01

    Full Text Available OBJETIVOS: Determinar los costos directos e indirectos asociados con la atención de los casos de dengue y de dengue hemorrágico o síndrome de choque por dengue (DH/SCD entre los años 1997 y 2003 en el Estado de Zulia, Venezuela. MÉTODOS: El número total de pacientes con dengue y DH/SCD se obtuvo de los registros de la Dirección Regional de Epidemiología del Estado de Zulia y de los informes de casos confirmados en la Sección de Virología del Instituto de Investigaciones Clínicas Dr. Américo Negrette, de la Facultad de Medicina, Universidad del Zulia, Maracaibo, entre el 1.° de enero de 1997 y el 31 de diciembre de 2003. Como costos directos se consideraron el costo de la atención médica de urgencia de todos los casos y los costos de hospitalización de los casos con DH/SCD (costo por día-cama y costos de laboratorio. Los costos asociados con la ausencia laboral de los enfermos mayores de 15 años y de las madres acompañantes de los enfermos menores de 15 años conformaron los costos indirectos, ajustados según la proporción de hombres y mujeres en la fuerza laboral activa del país. Para el cálculo se utilizó el salario mínimo anual y los resultados se expresaron en dólares estadounidenses, según la tasa de cambio promedio de cada año. RESULTADOS: En el período estudiado se atendieron 33 857 casos de dengue y de DH/SCD; de ellos, 30 251 (89,35% fueron de dengue y 3 606 (10,65% de DH/SCD. Seis de estos fallecieron (letalidad 0,2 por 100 casos de DH/SCD. Los costos directos fueron US$ 474 251,70; de esa suma, US$ 132 042,30 correspondieron a la atención en los servicios de urgencia y US$ 342 209,40 a los gastos de hospitalización de los casos con DH/SCD. Los costos indirectos ascendieron a US$ 873 825,84 y representaron 64,8% del gasto total (US$ 1 348 077,54 relacionado con esta enfermedad en los años estudiados. CONCLUSIONES: Este es el primer estudio acerca del impacto económico del dengue en el Estado de Zulia y

  8. Tri-phasic fever in dengue fever.

    Science.gov (United States)

    D, Pradeepa H; Rao, Sathish B; B, Ganaraj; Bhat, Gopalakrishna; M, Chakrapani

    2018-04-01

    Dengue fever is an acute febrile illness with a duration of 2-12 days. Our observational study observed the 24-h continuous tympanic temperature pattern of 15 patients with dengue fever and compared this with 26 others with fever due to a non-dengue aetiology. A tri-phasic fever pattern was seen among two-thirds of dengue fever patients, but in only one with an inflammatory disease. One-third of dengue fever patients exhibited a single peak temperature. Continuous temperature monitoring and temperature pattern analysis in clinical settings can aid in the early differentiation of dengue fever from non-dengue aetiology.

  9. Dengue antibodies in blood donors.

    Science.gov (United States)

    Ribas-Silva, Rejane Cristina; Eid, Andressa Ahmad

    2012-01-01

    Dengue is an urban arbovirus whose etiologic agent is a virus of the genus Flavorius with four distinct antigen serotypes (DENV-1, DENV-2, DENV-3 and DENV-4) that is transmitted to humans through the bite of the mosquito Aedes aegypti. The Campo Mourão region in Brazil is endemic for dengue fever. OBTECTIVE: The aim of this study was to evaluate the presence of IgG and IgM antibodies specific to the four serotypes of dengue in donors of the blood donor service in the city of Campo Mourão. Epidemiological records were evaluated and 4 mL of peripheral blood from 213 blood donors were collected in tubes without anticoagulant. Serum was then obtained and immunochromatographic tests were undertaken (Imuno-Rápido Dengue IgM/IgG(TM)). Individuals involved in the study answered a social and epidemiological questionnaire on data which included age, gender and diagnosis of dengue. Only three (1.4%) of the 213 blood tests were positive for IgG anti-dengue antibodies. No donors with IgM antibody, which identifies acute infection, were identified. The results of the current analysis show that the introduction of quantitative or molecular serological methods to determine the presence of anti-dengue antibodies or the detection of the dengue virus in blood donors in endemic regions should be established so that the quality of blood transfusions is guaranteed.

  10. Human Immune Response to Dengue Infections

    Science.gov (United States)

    1991-06-30

    had been immunized with yellow fever vaccine and later became infected with dengue 3 virus, responded best to dengue 3 antigen but also responded to...effective dengue virus subunit vaccines . We found evidence of marked T cell activation in patients with DHF. T cell activation in patients with DF was similar...Treatment and Control of Dengue Hemorrhagic Fever. World Health Organization, Geneva, Switzerland 7. Sabin AB (1952) Research on dengue during World

  11. Dengue human infection models to advance dengue vaccine development.

    Science.gov (United States)

    Larsen, Christian P; Whitehead, Stephen S; Durbin, Anna P

    2015-12-10

    Dengue viruses (DENV) currently infect approximately 400 million people each year causing millions to seek care and overwhelming the health care infrastructure in endemic areas. Vaccines to prevent dengue and therapeutics to treat dengue are not currently available. The efficacy of the most advanced candidate vaccine against symptomatic dengue in general and DENV-2 in particular was much lower than expected, despite the ability of the vaccine to induce neutralizing antibody against all four DENV serotypes. Because seroconversion to the DENV serotypes following vaccination was thought to be indicative of induced protection, these results have made it more difficult to assess which candidate vaccines should or should not be evaluated in large studies in endemic areas. A dengue human infection model (DHIM) could be extremely valuable to down-select candidate vaccines or therapeutics prior to engaging in efficacy trials in endemic areas. Two DHIM have been developed to assess the efficacy of live attenuated tetravalent (LATV) dengue vaccines. The first model, developed by the Laboratory of Infectious Diseases at the U. S. National Institutes of Health, utilizes a modified DENV-2 strain DEN2Δ30. This virus was derived from the DENV-2 Tonga/74 that caused only very mild clinical infection during the outbreak from which it was recovered. DEN2Δ30 induced viremia in 100%, rash in 80%, and neutropenia in 27% of the 30 subjects to whom it was given. The Walter Reed Army Institute of Research (WRAIR) is developing a DHIM the goal of which is to identify DENV that cause symptomatic dengue fever. WRAIR has evaluated seven viruses and has identified two that meet dengue fever criteria. Both of these models may be very useful in the evaluation and down-selection of candidate dengue vaccines and therapeutics. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  12. Bartonelosis (Fiebre de la Oroya o Verruga Peruana: ¿Enfermedad ocupacional?

    Directory of Open Access Journals (Sweden)

    R. Cesar Gonzáles

    2007-12-01

    Full Text Available La Bartonella bacilliformis es un parásito bacteriano intracelular facultativo de los eritrocitos humanos y de las células endoteliales. La enfermedad de Carrión, fiebre de La Oroya y Verruga Peruana son todos términos que describen las consecuencias patológicas de la infección humana por Bartonella bacilliformis. (1 Aunque las infecciones que involucran especies de Bartonella, tales como Bartonella henselae y Bartonella quintana, ocurren en todo el mundo, la enfermedad de Carrión es endémica únicamente en Sudamérica. (14 Las infecciones por B. bacilliformis son un problema de salud en numerosas áreas rurales de Sudamérica y para los viajeros que visitan esas regiones. Se han reportado brotes de bartonelosis en las regiones montañosas de Perú, Ecuador y Colombia. (1 La Lutzomyia verrucarum es el principal vector para la transmisión de la bacteria al ser humano; la hembra del mosquito transmite el patógeno durante su alimentación nocturna de sangre humana. Presumiblemente el insecto se alimenta de sangre de un individuo infectado y disemina el patógeno por medio de su saliva durante la siguiente ingesta de sangre. La bacteria no es contagiosa entre humanos. (1 Presentamos un enfoque laboral de la enfermedad en trabajadores que realizan desplazamientos continuos a zonas endémicas y analizamos sus posibles consecuencias.Bartonella bacilliformis is a facultative intracellular bacterial parasite of human erythrocytes and endotelial cells. Carrion’s disease, Oroya fever and Peruvian wart are all terms describing the pathological consequences of human infection with Bartonella bacilliformis. (1 Although infections involving the Bartonella species, such as Bartonella henselae and Bartonella Quintana occur worldwide, Carrion’s disease is uniquely endemic to South America. (14 Bartonella baciliformis infections are a health problem in many rural areas of South America and to travellers who visit these regions. Outbreaks of

  13. DENGUE VACCINE, CHALLENGES, DEVELOPMENT AND STRATEGIES

    Directory of Open Access Journals (Sweden)

    Dewi Marbawati

    2014-08-01

    Full Text Available ABSTRAKPenyakit demam Dengue endemik di lebih dari 100 negara di dunia. Obat anti virus Dengue efektif belum ditemukan danpengendalian vektor dinilai kurang efektif, sehingga diperlukan upaya pencegahan dengan vaksinasi. Vaksin Dengue yangideal adalah murah, mencakup 4 serotipe, efektif dalam memberikan kekebalan, cukup diberikan sekali seumur hidup, aman,memberi kekebalan jangka panjang, stabil dalam penyimpanan dan stabil secara genetis (tidak bermutasi. Beberapakandidat vaksin yang telah dan sedang dikembangkan oleh para peneliti di seluruh dunia adalah tetravalent live attenuatedvaccine, vaksin Chimera (ChimeriVax, vaksin subunit dan vaksin DNA. Vaksin Dengue dipandang sebagai pendekatan yangefektif dan berkesinambungan dalam mengendalikan penyakit Dengue. Tahun 2003 telah terbentuk Pediatric DengueVaccine Initiative (PDVI, yaitu sebuah konsorsium internasional yang bergerak dalam advokasi untuk meyakinkanmasyarakat internasional akan penting dan mendesaknya vaksin Dengue. Konsorsium vaksin Dengue Indonesia saat iniberupaya mengembangkan vaksin Dengue dengan menggunakan strain virus lokal.Kata kunci: Dengue, virus, vaksinABSTRACTDengue fever is endemic in more than 100 countries in the world. The effective dengue antiviral drug has not been found yet,and vector control is considered less effective. Prevention program by vaccination is needed. An ideal dengue vaccine shouldbe inexpensive, covering four serotypes (tetravalent, effective in providing immunity, given once a lifetime, safe, stable instorage and genetically. Several vaccine candidates have been and are being developed included attenuated tetravalentvaccine, ChimeriVax, sub- unit vaccines and DNA vaccines. Dengue vaccine is seen as an effective and sustainable approachto controll Dengue infection. In 2003, Pediatric Dengue Vaccine Initiative (PDVI has been formed as an internationalconsortium involved in advocacy to convince the international community about the essence and urgency

  14. Sofosbuvir as treatment against dengue?

    Science.gov (United States)

    Gan, Chye Sheng; Lim, See Khai; Chee, Chin Fei; Yusof, Rohana; Heh, Choon Han

    2018-02-01

    Dengvaxia ® (CTD-TDV), the only licensed tetravalent dengue vaccine by Sanofi Pasteur, was made available since 2015. However, administration of CTD-TDV, in general, has not received the prequalification recommendation from the World Health Organization. Having a universal antidengue agent for treatment will therefore beneficial. Accordingly, the development of nucleoside inhibitors specific to dengue viral polymerase that perturb dengue infection has been studied by many. Alternatively, we have used a marketed anti-HCV prodrug sofosbuvir to study its in silico and in vitro effects against dengue. As a result, the active metabolite of sofosbuvir (GS-461203) was predicted to bind to the catalytic motif (Gly-Asp-Asp) of dengue viral polymerase with binding affinity of -6.9 kcal/mol. Furthermore, sofosbuvir demonstrated excellent in vitro viral inhibition with an EC 90 of 0.4 μm. In addition, this study demonstrated the requirement of specific liver enzymes to activate the prodrug into GS-461203 to exert its antidengue potential. All in all, sofosbuvir should be subjected to in-depth studies to provide information of its efficacy toward dengue and its lead potential as DENV polymerase inhibitor in human subjects. In conclusion, we have expended the potential of the clinically available drug sofosbuvir as treatment for dengue. © 2017 John Wiley & Sons A/S.

  15. Ecg manifestations in dengue infection

    International Nuclear Information System (INIS)

    Tarique, S.; Murtaza, G.; Asif, S.; Qureshi, I.H.

    2013-01-01

    To determine the frequency of ECG changes in patients with dengue fever and dengue hemorrhagic fever. Place of study: Department of Medicine, Mayo Hospital Lahore Duration of study: September to November 201 Study design: Cross sectional analytical study Patient and methods: 116 patients with dengue infection were enrolled in the study. Their clinical presentation and examination was duly noted. Each patient had baseline and then regular monitoring of blood counts, metabolic profile and fluid status. Patients with Dengue Hemorrhagic fever underwent radiological examination in form of chest radiograph and ultrasound abdomen. ECG was carried out in all patients. Results: Out of 116 patients, 61(52.6%) suffered from Dengue Fever and 55(47.4%) had Dengue Hemorrhagic Fever. Overall 78 patients had normal ECG. Abnormal ECG findings like tachycardia, bradycardia, supraventricular tachycardia, left bundle branch block, ST depression, poor progression of R wave were noted. There was no significant relationship of ECG findings with the disease. Conclusion: ECG changes can occur in dengue infection with or without cardiac symptoms. Commonly noted findings were ST depression and bradycardia. (author)

  16. Aislamiento rápido del virus dengue 3 por el método de shell vial en el brote de dengue en Lima

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    Victoria Gutiérrez P

    2005-07-01

    Full Text Available El aislamiento de virus dengue con los métodos tradicionales demora hasta un mes, en situaciones de emergencia como el brote de dengue clásico en el distrito de Comas-Lima entre abril y mayo de 2005, es necesario un diagnóstico precoz. Se procesaron 117 muestras de sueros de pacientes con diagnóstico clínico de dengue clásico en fase virémica procedentes la zona del brote, mediante el método de shell vial para el aislamiento del virus dengue en la línea celular C6-36, se identificó el serotipo del virus mediante inmunofluorescencia indirecta (IFI empleando anticuerpos monoclonales. Se logró el aislamiento del virus DEN-3 al quinto día de cosecha en el 48,7% (57/117 de los sueros. Los resultados sugieren que el método de shell vial, por el menor tiempo de aislamiento que el método tradicional, puede ser implementado como método de diagnóstico y usado en la vigilancia epidemiológica del virus dengue.

  17. ADE and dengue vaccination.

    Science.gov (United States)

    Martínez-Vega, Ruth Aralí; Carrasquila, Gabriel; Luna, Expedito; Ramos-Castañeda, José

    2017-07-13

    The vaccine against Dengue virus (DENV), Dengvaxia® (CYD), produced by Sanofi-Pasteur, has been registered by several national regulatory agencies; nevertheless, the performance and security of this vaccine have been challenged in a series of recent papers. In this work, we intend to contribute to the debate by analyzing the concept of an enhancing vaccine, presenting objections to the epidemiological model base of the concept and, likewise, presenting data that contradict that concept. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Sarcoma de Kaposi en paciente con SIDA

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    Jesús Ramón León Polanco

    2015-01-01

    Full Text Available Se presenta el caso de un paciente masculino de 33 años de edad, con antecedentes de VIH-SIDA desde hace 10 años, que se mantiene en tratamiento con antirretrovirales. Durante todo este tiempo ha presentado varios episodios de infecciones respiratorias, incluyendo tuberculosis pulmonar 5 años atrás. Acude a consulta refiriendo edemas en miembros inferiores acompañado de lesiones en piel de color violáceo de un año de evolución, previamente interpretado como linfangitis rebelde al tratamiento y que se extendió a la cara interna de los muslos y a los miembros inferiores. Con pérdida de peso, no prurito en las lesiones, fiebre, lesiones en la mucosa oral. Se determinó hemoglobina 89 g/L, leucocitos 4,5 x 109 /L, se estudiaron las funciones hepática y renales resultando normales. Radiografías de tórax y ultrasonido abdominal normales. Se realizó estudio anatomopatológico de piel que informó Sarcoma de Kaposi. Se impuso tratamiento con quimioterapia

  19. Epidemia de dengue en Nicaragua, 1985 Epidemic dengue in Nicaragua 1985

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    G. Kouri

    1991-10-01

    Full Text Available En el segundo semestre de 1985, coincidiendo con el período de lluvias se produjo en Nicaragua una epidemia de Dengue en la que se reportaron 17,483 casos. La mayor morbilidad y las más elevadas tasas de ataque se registraron entre Agosto y Noviembre, siendo afectadas fundamentalmente las regiones II (León y Chinandega, III (Managua y IV (Masaya, Granada, Carazo, Rivas que acumularon el 89% de los reportes. Estas regiones se corresponden precisamente con las zonas más densamente pobladas ubicadas en la costa del Pacífico, en donde se encuentran los núcleos urbanos mas importantes y populosos del país. León y Chinandega fueron las ciudades mas afectadas, pues reportaron el 41% del total de casos registrados. El 66.8% de los casos eran adultos y el 57.6% del sexo femenino. La tasa global de ataque para el país fue de 55.24 x 10.000 habitantes. Una campaña de lucha antivectorial, fue iniciada de inmediato, manteniéndose en forma intensiva hasta el mes de Octubre. Al final de este período la morbilidad disminuyó considerablemente y la enfermedad entró en una fase de escasos reportes y posiblemente de endemia. Se reportaron 7 adultos fallecidos que fueron considerados como portadores de una FHD/SCD por un grupo mixto de patólogos y clínicos teniendo en cuenta la experiencia adquirida en los pacientes adultos durante la epidemia ocurrida en Cuba en 1981. El brote fue interpretado como una epidemia de Dengue Clásico en la cual se produjeron 7 casos fatales. Se aislaron los serotipos 1 y 2 del Dengue en sueros de fase aguda de pacientes y el serotipo 1 en el de uno de los fallecidos.In the second half of the year 1985, during the rainy season, an epidemic of Dengue Fever was recognized in Nicaragua. A total of 17.483 cases were reported by the health services. The highest morbidity and attack rates were reported between August and November of the same year. Regions II (Leon and Chinandega, III (Managua and IV (Masaya, Granada, Carazo y

  20. Hemoterapia e febre Dengue Blood banking e Dengue fever

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    Estácio F. Ramos

    2008-02-01

    Full Text Available Dengue is an endemic/epidemic arboviral disease with a variable symptomatic benign course, but potentially fatal. Once in an inhabited area, the disease will exist forever, with the best achievement being to keep vectors suppressed and the disease under control. Tiger mosquitoes (aedes aegypti, aedes albopictus are active breeders and urban hunters, becoming resistant to pesticides. Global warming and population growth are propelling the disease worldwide at tropical and subtropical regions, victimizing new populations. Dengue virus is very infective, and has been transmitted by needlestick, intrapartum, through blood transfusion and mucosal contact with blood. One patient got dengue while undergoing bone marrow transplantation. We address the growing dengue epidemics in Brazil, with more than half a million official cases in 2007, to estimate the risks of transfusion transmitted dengue. Calculations however were surpassed by reality: the major Blood Center in Brazil (FHSP-USP has found dengue virus in one out of each thousand blood units. In 2007, industry sold 2,6 million disposable blood bags in Brazil. Plotting data from FHSP-USP to the whole country, 2600 blood units would have been infective. Through blood components, around 5000 patients must have received dengue virus intravenously. Beatty et al. estimated to be 1:1300 the risk for dengue transmission through blood transfusion in Puerto Rico, close to what has been demonstrated in Sao Paulo. Throughout Brazil, the average risk may be lower, but the epidemics grows towards a worst scenario. Whatever the risk is, it imposes that all blood units in Brazil (and wherever dengue is endemic must be EIA tested for dengue NS1 antigen. This marker appears early after infection, and the EIA testing platform is available at all blood banks. Also, donors must report febrile states up to two weeks after donation. Morbidity from dengue virus injected in hospitalized patients is unknown, but it may lead

  1. Aspectos críticos do controle da febre amarela no Brasil Aspectos críticos del control de la fiebre amarilla en Brasil Critical aspects of yellow fever control in Brazil

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    Pedro Luiz Tauil

    2010-06-01

    Full Text Available São apresentados aspectos epidemiológicos e do controle da febre amarela no Brasil, considerando os ciclos de transmissão silvestre e urbano. Sem registros de transmissão no Brasil desde 1942, houve casos de febre amarela urbana em 2008 no Paraguai, depois de mais de 50 anos sem essa ocorrência nas Américas. A redução do número dos casos silvestres e a manutenção da eliminação dos casos urbanos são os dois principais objetivos do controle da febre amarela no Brasil. Embora haja consenso quanto às medidas que devem ser tomadas nas áreas endêmicas para a forma silvestre, isso não ocorre em relação às áreas infestadas pelo Aedes aegypti. São discutidos argumentos favoráveis e contrários à expansão da área de vacinação. Há necessidade de estudos ambientais e entomológicos para o reconhecimento de áreas receptivas para transmissão silvestre, mesmo que estejam silentes há muitos anos.Se presentan aspectos epidemiológicos y del control de la fiebre amarilla en Brasil, considerando los ciclos de transmisión silvestre y urbana. Sin registros de transmisión en Brasil desde 1942, hubo casos de fiebre amarilla urbana en 2008 en Paraguay, después de más de 50 años sin ocurrir en las Américas. La reducción del número de casos silvestre y el mantenimiento de la eliminación de los casos urbanos son los dos principales objetivos del control de la fiebre amarilla en Brasil. A pesar de que exista consenso con respecto a las medidas que deben ser tomadas en las áreas endémicas para la forma silvestre, esto no ocurre con relación a las áreas infestadas por el Aedes aegypti. Son discutidos argumentos favorables y contrarios a la expansión del área de vacunación. Hay necesidad de estudios ambientales y entomológicos para el reconocimiento de áreas receptivas para transmisión silvestre, aunque se encuentren silentes desde hace muchos años.This paper presents epidemiological and control characteristics of yellow

  2. Appendicular perforation in dengue fever: our experience

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    Gunjan Desai

    2014-09-01

    Full Text Available Dengue viral infections have become one of major emerging infectious diseases in the tropics. Acute abdomen occurring in dengue viral infection is not uncommon. The spectrums of acute surgical emergencies which raise suspicion of an abdominal catastrophe in patients presenting with dengue fever include acute pancreatitis, acute acalculous cholecystitis, non-specific peritonitis and very rarely acute appendicitis. The presence of low white cell count and platelet count can raise suspicion of a diagnosis of dengue in a patient presenting with acute abdominal pain, during a dengue epidemic. We herein report three patients with dengue fever who had appendicular perforation during the course of their viral fever.

  3. Dengue fever and dengue haemorrhagic fever in adolescents and adults.

    Science.gov (United States)

    Tantawichien, Terapong

    2012-05-01

    Dengue fever (DF) is endemic in tropical and subtropical zones and the prevalence is increasing across South-east Asia, Africa, the Western Pacific and the Americas. In recent years, the spread of unplanned urbanisation, with associated substandard housing, overcrowding and deterioration in water, sewage and waste management systems, has created ideal conditions for increased transmission of the dengue virus in tropical urban centres. While dengue infection has traditionally been considered a paediatric disease, the age distribution of dengue has been rising and more cases have been observed in adolescents and adults. Furthermore, the development of tourism in the tropics has led to an increase in the number of tourists who become infected, most of whom are adults. Symptoms and risk factors for dengue haemorrhagic fever (DHF) and severe dengue differ between children and adults, with co-morbidities and incidence in more elderly patients associated with greater risk of mortality. Treatment options for DF and DHF in adults, as for children, centre round fluid replacement (either orally or intravenously, depending on severity) and antipyretics. Further data are needed on the optimal treatment of adult patients.

  4. Recent advances in understanding dengue

    Science.gov (United States)

    Yacoub, Sophie; Mongkolsapaya, Juthathip; Screaton, Gavin

    2016-01-01

    Dengue is an emerging threat to billions of people worldwide. In the last 20 years, the incidence has increased four-fold and this trend appears to be continuing. Caused by one of four viral serotypes, dengue can present as a wide range of clinical phenotypes with the severe end of the spectrum being defined by a syndrome of capillary leak, coagulopathy, and organ impairment. The pathogenesis of severe disease is thought to be in part immune mediated, but the exact mechanisms remain to be defined. The current treatment of dengue relies on supportive measures with no licensed therapeutics available to date. There have been recent advances in our understanding of a number of areas of dengue research, of which the following will be discussed in this review: the drivers behind the global dengue pandemic, viral structure and epitope binding, risk factors for severe disease and its pathogenesis, as well as the findings of recent clinical trials including therapeutics and vaccines. We conclude with current and future dengue control measures and key areas for future research. PMID:26918159

  5. Recent advances in understanding dengue.

    Science.gov (United States)

    Yacoub, Sophie; Mongkolsapaya, Juthathip; Screaton, Gavin

    2016-01-01

    Dengue is an emerging threat to billions of people worldwide. In the last 20 years, the incidence has increased four-fold and this trend appears to be continuing. Caused by one of four viral serotypes, dengue can present as a wide range of clinical phenotypes with the severe end of the spectrum being defined by a syndrome of capillary leak, coagulopathy, and organ impairment. The pathogenesis of severe disease is thought to be in part immune mediated, but the exact mechanisms remain to be defined. The current treatment of dengue relies on supportive measures with no licensed therapeutics available to date. There have been recent advances in our understanding of a number of areas of dengue research, of which the following will be discussed in this review: the drivers behind the global dengue pandemic, viral structure and epitope binding, risk factors for severe disease and its pathogenesis, as well as the findings of recent clinical trials including therapeutics and vaccines. We conclude with current and future dengue control measures and key areas for future research.

  6. Dengue viruses – an overview

    Directory of Open Access Journals (Sweden)

    Anne Tuiskunen Bäck

    2013-08-01

    Full Text Available Dengue viruses (DENVs cause the most common arthropod-borne viral disease in man with 50–100 million infections per year. Because of the lack of a vaccine and antiviral drugs, the sole measure of control is limiting the Aedes mosquito vectors. DENV infection can be asymptomatic or a self-limited, acute febrile disease ranging in severity. The classical form of dengue fever (DF is characterized by high fever, headache, stomach ache, rash, myalgia, and arthralgia. Severe dengue, dengue hemorrhagic fever (DHF, and dengue shock syndrome (DSS are accompanied by thrombocytopenia, vascular leakage, and hypotension. DSS, which can be fatal, is characterized by systemic shock. Despite intensive research, the underlying mechanisms causing severe dengue is still not well understood partly due to the lack of appropriate animal models of infection and disease. However, even though it is clear that both viral and host factors play important roles in the course of infection, a fundamental knowledge gap still remains to be filled regarding host cell tropism, crucial host immune response mechanisms, and viral markers for virulence.

  7. Acute disseminated encephalomyelitis in dengue viral infection.

    Science.gov (United States)

    Wan Sulaiman, Wan Aliaa; Inche Mat, Liyana Najwa; Hashim, Hasnur Zaman; Hoo, Fan Kee; Ching, Siew Mooi; Vasudevan, Ramachandran; Mohamed, Mohd Hazmi; Basri, Hamidon

    2017-09-01

    Dengue is the most common arboviral disease affecting many countries worldwide. An RNA virus from the flaviviridae family, dengue has four antigenically distinct serotypes (DEN-1-DEN-4). Neurological involvement in dengue can be classified into dengue encephalopathy immune-mediated syndromes, encephalitis, neuromuscular or dengue muscle dysfunction and neuro-ophthalmic involvement. Acute disseminated encephalomyelitis (ADEM) is an immune mediated acute demyelinating disorder of the central nervous system following recent infection or vaccination. This monophasic illness is characterised by multifocal white matter involvement. Many dengue studies and case reports have linked ADEM with dengue virus infection but the association is still not clear. Therefore, this article is to review and discuss concerning ADEM in dengue as an immune-medicated neurological complication; and the management strategy required based on recent literature. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. Entre la fiebre del oro y el polvo de las voladuras… Cuerpos y emociones en contextos de mineralización.

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    Horacio Machado Aráoz

    2013-07-01

    Full Text Available Normal 0 21 false false false ES-AR X-NONE AR-SA A partir de la constatación de las grandes transformaciones sociales provocadas por el desembarco de la megaminería transnacional en la Provincia de Catamarca,  el presente trabajo se plantea abordar el análisis de la conflictividad ‘minera' desde la perspectiva de sus impactos microbiopolíticos, esto es, en  el plano de los cuerpos, las emociones y los sentimientos. Considerando que se trata de un aspecto crucial de los procesos sociales que se verifican en los nuevos escenarios del extractivismo minero, este trabajo procura desarrollar una ecología política de las emociones como clave para caracterizar los conflictos mineros, así como los efectos eco-biopolíticos que se producen en las comunidades locales intervenidas. Apelando a registros etnográficos, se exponen diferentes dimensiones de los cambios sociales resultantes de las políticas mineras sobre los cuerpos y las emociones. Con los conceptos de fiebre del oro y mineralización social, se busca brindar una hermenéutica crítica de estos procesos orientada a visibilizar lo que se entiende como sus rasgos y efectos neocoloniales. /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;}

  9. The dengue vaccine pipeline: Implications for the future of dengue control

    OpenAIRE

    Schwartz, Lauren M.; Halloran, M. Elizabeth; Durbin, Anna P.; Longini Jr., Ira M.

    2015-01-01

    Dengue has become the most rapidly expanding mosquito-borne infectious disease on the planet, surpassing malaria and infecting at least 390 million people per year. There is no effective treatment for dengue illness other than supportive care, especially for severe cases. Symptoms can be mild or life-threatening as in dengue hemorrhagic fever and dengue shock syndrome. Vector control has been only partially successful in decreasing dengue transmission. The potential use of safe and effective ...

  10. De miasmas a mosquitos: el pensamiento médico sobre la fiebre amarilla en Yucatán, 1890-1920 From miasmas to mosquitoes: medical thought on yellow fever in Yucatan, 1890-1920

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    Carlos Alcalá Ferráez

    2012-03-01

    Full Text Available La fiebre amarilla fue un problema de salud pública desde la época colonial debido a la frecuencia con que se presentaba en forma epidémica y a su alta letalidad. El objetivo de este trabajo es analizar el pensamiento médico y su evolución con respecto al vómito prieto entre 1890 y 1921 en Yucatán. Dos aspectos serán abordados: algunos antecedentes con respecto a la enfermedad y las ideas predominantes hasta 1881; y la propuesta de Carlos Finlay para vencer el escepticismo ante su teoría por parte de la comunidad médica. En segundo lugar se analizará la mezcla de las ideas miasmáticas y bacterianas. En tercer lugar, se mostrará cómo, a partir de la demostración de sus postulados, la mirada médica se dirigió al exterminio del mosquito transmisor de este padecimiento.Yellow fever has been a public health concern since colonial days because of its frequent epidemics and high mortality rate. This analysis of medical thought about "the black vomit" in the Yucatan and the evolution of this thinking from 1890 through 1921 first addresses some of the disease's antecedents and preponderant ideas prior to 1881 as well as Carlos Finlay's efforts to convince the medical community that his theory was right. The article goes on to analyze the co-existence of miasmatic and bacterial ideas and to show how medical initiatives began focusing on eradication of the mosquito transmitter once Finlay's postulates had been demonstrated.

  11. Dengue Virus and Autophagy

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    Nicholas S. Heaton

    2011-08-01

    Full Text Available Several independent groups have published that autophagy is required for optimal RNA replication of dengue virus (DENV. Initially, it was postulated that autophagosomes might play a structural role in replication complex formation. However, cryo-EM tomography of DENV replication complexes showed that DENV replicates on endoplasmic reticulum (ER cisternae invaginations and not on classical autophagosomes. Recently, it was reported that autophagy plays an indirect role in DENV replication by modulating cellular lipid metabolism. DENV-induced autophagosomes deplete cellular triglycerides that are stored in lipid droplets, leading to increased β-oxidation and energy production. This is the first example of a virus triggering autophagy to modulate cellular physiology. In this review, we summarize these data and discuss new questions and implications for autophagy during DENV replication.

  12. Virus del dengue de serotipo 1 (DENV-1 de Colombia: su contribución a la presentación del dengue en el departamento de Santander

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    Raquel E. Ocazionez-Jiménez

    2013-08-01

    Full Text Available Introducción. Los cuatro serotipos del virus del dengue circularon en el departamento de Santander entre 1998 y 2008. No existe información sobre el papel del serotipo 1 (DENV-1 en la epidemiología de la enfermedad. Objetivo. Analizar la relación entre el cambio de predominancia del (DENV-1 con su diversificación genética, predominancia de los otros serotipos y presentación del dengue grave. Materiales y métodos. La diversificación genética se estudió por análisis filogenético usando la secuencia del gen E de 12 cepas del virus. Para el análisis se utilizaron datos sobre predominancia delos serotipos obtenidos en estudios previos y datos oficiales de incidencia del dengue. Resultados. Los virus seleccionados se agruparon en el genotipo V junto a (DENV-1 de países de Latinoamérica y se evidenció segregación en cuatro linajes. Los cambios en la predominancia del virus coincidieron con el reemplazo de linaje y esto, a su vez, con incremento en la prevalencia de DENV-2y DENV-3, e incremento del dengue grave. Conclusión. La diversificación genética podría contribuir a cambios de predominancia de (DENV-1, y la relación del virus con el DENV-2 y DENV-3 en situaciones que favorecen la presentación de casos graves. Se necesitan más estudios para precisar el papel de los serotipos en la epidemiología del dengue. doi: http://dx.doi.org/10.7705/biomedica.v33i0.717

  13. Reviewing dengue: still a neglected tropical disease?

    Science.gov (United States)

    Horstick, Olaf; Tozan, Yesim; Wilder-Smith, Annelies

    2015-04-01

    Dengue is currently listed as a "neglected tropical disease" (NTD). But is dengue still an NTD or not? Classifying dengue as an NTD may carry advantages, but is it justified? This review considers the criteria for the definition of an NTD, the current diverse lists of NTDs by different stakeholders, and the commonalities and differences of dengue with other NTDs. We also review the current research gaps and research activities and the adequacy of funding for dengue research and development (R&D) (2003-2013). NTD definitions have been developed to a higher precision since the early 2000s, with the following main features: NTDs are characterised as a) poverty related, b) endemic to the tropics and subtropics, c) lacking public health attention, d) having poor research funding and shortcomings in R&D, e) usually associated with high morbidity but low mortality, and f) often having no specific treatment available. Dengue meets most of these criteria, but not all. Although dengue predominantly affects resource-limited countries, it does not necessarily only target the poor and marginalised in those countries. Dengue increasingly attracts public health attention, and in some affected countries it is now a high profile disease. Research funding for dengue has increased exponentially in the past two decades, in particular in the area of dengue vaccine development. However, despite advances in dengue research, dengue epidemics are increasing in frequency and magnitude, and dengue is expanding to new areas. Specific treatment and a highly effective vaccine remain elusive. Major research gaps exist in the area of integrated surveillance and vector control. Hence, although dengue differs from many of the NTDs, it still meets important criteria commonly used for NTDs. The current need for increased R&D spending, shared by dengue and other NTDs, is perhaps the key reason why dengue should continue to be considered an NTD.

  14. Reviewing dengue: still a neglected tropical disease?

    Directory of Open Access Journals (Sweden)

    Olaf Horstick

    2015-04-01

    Full Text Available Dengue is currently listed as a "neglected tropical disease" (NTD. But is dengue still an NTD or not? Classifying dengue as an NTD may carry advantages, but is it justified? This review considers the criteria for the definition of an NTD, the current diverse lists of NTDs by different stakeholders, and the commonalities and differences of dengue with other NTDs. We also review the current research gaps and research activities and the adequacy of funding for dengue research and development (R&D (2003-2013. NTD definitions have been developed to a higher precision since the early 2000s, with the following main features: NTDs are characterised as a poverty related, b endemic to the tropics and subtropics, c lacking public health attention, d having poor research funding and shortcomings in R&D, e usually associated with high morbidity but low mortality, and f often having no specific treatment available. Dengue meets most of these criteria, but not all. Although dengue predominantly affects resource-limited countries, it does not necessarily only target the poor and marginalised in those countries. Dengue increasingly attracts public health attention, and in some affected countries it is now a high profile disease. Research funding for dengue has increased exponentially in the past two decades, in particular in the area of dengue vaccine development. However, despite advances in dengue research, dengue epidemics are increasing in frequency and magnitude, and dengue is expanding to new areas. Specific treatment and a highly effective vaccine remain elusive. Major research gaps exist in the area of integrated surveillance and vector control. Hence, although dengue differs from many of the NTDs, it still meets important criteria commonly used for NTDs. The current need for increased R&D spending, shared by dengue and other NTDs, is perhaps the key reason why dengue should continue to be considered an NTD.

  15. Dengue fever: a Wikipedia clinical review

    OpenAIRE

    Heilman, James M; Wolff, Jacob De; Beards, Graham M; Basden, Brian J

    2014-01-01

    Dengue fever, also known as breakbone fever, is a mosquito-borne infectious tropical disease caused by the dengue virus. Symptoms include fever, headache, muscle and joint pains, and a characteristic skin rash that is similar to measles. In a small proportion of cases, the disease develops into life-threatening dengue hemorrhagic fever, which results in bleeding, thrombocytopenia, and leakage of blood plasma, or into dengue shock syndrome, in which dangerously low blood pressure occurs. Treat...

  16. Dengue fever outbreak: a clinical management experience

    International Nuclear Information System (INIS)

    Ahmed, S.; Illyas, M.

    2008-01-01

    To determine the frequency of dengue as a cause of fever and compare the clinical and haematological characteristics of Dengue-probable and Dengue-proven cases. All patients with age above 14 years, who were either hospitalized or treated in medical outdoor clinic due to acute febrile illness, were evaluated for clinical features of Dengue Fever (DF), Dengue haemorrhagic fever (DHF) and Dengue Shock Syndrome (DSS). Patients showing typical clinical features and haematological findings suggestive of Dengue fever (As per WHO criteria) were evaluated in detail for comparison of probable and confirmed cases of Dengue fever. All other cases of acute febrile illness, not showing clinical features or haematological abnormalities of Dengue fever, were excluded. The clinical and laboratory features were recorded on SPSS 11.0 programme and graded where required, for descriptive and statistical analysis. Out of 5200 patients with febrile illness, 107 (2%) presented with typical features of DF, 40/107 (37%) were Dengue-proven while 67/107 (63%) were Dengue-probable. Out of Dengue-proven cases, 38 were of DF and 2 were of DHF. Day 1 temperature ranged from 99-105 degreeC (mean 101 degree C). Chills and rigors were noticed in 86 (80%), myalgia in 67%, headache in 54%, pharyngitis in 35%, rash in 28%, and bleeding manifestations in 2% cases. Hepatomegaly in 1(0.5%), lymphadenopathy in 1 (0.5%) and splenomegaly in 12 (11.2%) cases. Leucopoenia (count 40 U/L in 57% cases. Frequency of clinically suspected dengue virus infection was 107 (2%), while confirmed dengue fever cases were 40 (0.8%) out of 5200 fever cases. Fever with chills and rigors, body aches, headache, myalgia, rash, haemorrhagic manifestations, platelet count, total leukocyte count, and ALT, are parameters to screen the cases of suspected dengue virus infection, the diagnosis cannot be confirmed unless supported by molecular studies or dengue specific IgM. (author)

  17. Dengue virus markers of virulence and pathogenicity

    OpenAIRE

    Rico-Hesse, Rebeca

    2009-01-01

    The increased spread of dengue fever and its more severe form, dengue hemorrhagic fever, have made the study of the mosquito-borne dengue viruses that cause these diseases a public health priority. Little is known about how or why the four different (serotypes 1–4) dengue viruses cause pathology in humans only, and there have been no animal models of disease to date. Therefore, there are no vaccines or antivirals to prevent or treat infection and mortality rates of dengue hemorrhagic fever pa...

  18. Determinantes de la transmisión de dengue en Veracruz: un abordaje ecológico para su control Dengue fever transmission in Veracruz, Mexico: an ecological approach to disease control

    Directory of Open Access Journals (Sweden)

    Javier Escobar-Mesa

    2003-01-01

    Full Text Available OBJETIVO: Identificar los factores ambientales, sociales y demográficos que contribuyen a explicar las diferencias en la transmisión de dengue en Veracruz, México, durante el periodo 1995-1998 y definir las áreas de riesgo para promover un mejor control del problema. MATERIAL Y MÉTODOS: Bajo un diseño ecológico se analizó una base de datos con el número de casos de dengue que se presentaron en 1 249 localidades en las 11 Jurisdicciones Sanitarias del estado de Veracruz durante el periodo 1995-1998. Cada una de las localidades fue identificada de acuerdo con su altitud, latitud y longitud, y con el número total de la población por sexo, el número de viviendas y la dotación de servicios públicos. Se tomó también el índice de marginación por localidad del Consejo Nacional de Población. RESULTADOS: El dengue en Veracruz se registró en 17% de las localidades y en sólo 6% de ellas se concentraron 70% de los casos de dengue en el estado. Las localidades repetidoras de dengue fueron grandes centros urbanos, con baja marginación y extensa dotación de servicios públicos. El dengue sí se transmite en las áreas rurales del estado aunque la transmisión es ocasional. El promedio de casos de dengue reportados en las localidades dependió del tamaño de la misma y del número de años que reportaron dengue durante el periodo. Se reporta un umbral poblacional para la transmisión. CONCLUSIONES: Se identificaron las localidades repetidoras de dengue que concentran 70% de los casos, y las determinantes sociales y ambientales de la transmisión. Este enfoque de riesgo puede mejorar el control y tener un impacto significativo en la prevención de la transmisión en las zonas de mayor riesgo.OBJECTIVE:To assess the ecological, social, and demographic factors associated with the transmission of dengue virus infection in Veracruz, Mexico, and to identify risk areas to target control measures. MATERIAL AND METHODS: This ecological study

  19. Dengue: an arthropod-borne disease of global importance.

    NARCIS (Netherlands)

    Mairuhu, A.T.; Wagenaar, J.; Brandjes, D.P.; Gorp, E. van

    2004-01-01

    Dengue viruses cause a variable spectrum of disease that ranges from an undifferentiated fever to dengue fever to the potentially fatal dengue shock syndrome. Due to the increased incidence and geographical distribution of dengue in the last 50 years, dengue is becoming increasingly recognised as

  20. Cells in Dengue Virus Infection In Vivo

    Directory of Open Access Journals (Sweden)

    Sansanee Noisakran

    2010-01-01

    Full Text Available Dengue has been recognized as one of the most important vector-borne emerging infectious diseases globally. Though dengue normally causes a self-limiting infection, some patients may develop a life-threatening illness, dengue hemorrhagic fever (DHF/dengue shock syndrome (DSS. The reason why DHF/DSS occurs in certain individuals is unclear. Studies in the endemic regions suggest that the preexisting antibodies are a risk factor for DHF/DSS. Viremia and thrombocytopenia are the key clinical features of dengue virus infection in patients. The amounts of virus circulating in patients are highly correlated with severe dengue disease, DHF/DSS. Also, the disturbance, mainly a transient depression, of hematological cells is a critical clinical finding in acute dengue patients. However, the cells responsible for the dengue viremia are unresolved in spite of the intensive efforts been made. Dengue virus appears to replicate and proliferate in many adapted cell lines, but these in vitro properties are extremely difficult to be reproduced in primary cells or in vivo. This paper summarizes reports on the permissive cells in vitro and in vivo and suggests a hematological cell lineage for dengue virus infection in vivo, with the hope that a new focus will shed light on further understanding of the complexities of dengue disease.

  1. Reemergence of Dengue in Southern Texas, 2013

    Science.gov (United States)

    Thomas, Dana L.; Santiago, Gilberto A.; Abeyta, Roman; Hinojosa, Steven; Torres-Velasquez, Brenda; Adam, Jessica K.; Evert, Nicole; Caraballo, Elba; Hunsperger, Elizabeth; Muñoz-Jordán, Jorge L.; Smith, Brian; Banicki, Alison; Tomashek, Kay M.; Gaul, Linda

    2016-01-01

    During a dengue epidemic in northern Mexico, enhanced surveillance identified 53 laboratory-positive cases in southern Texas; 26 (49%) patients acquired the infection locally, and 29 (55%) were hospitalized. Of 83 patient specimens that were initially IgM negative according to ELISA performed at a commercial laboratory, 14 (17%) were dengue virus positive by real-time reverse transcription PCR performed at the Centers for Disease Control and Prevention. Dengue virus types 1 and 3 were identified, and molecular phylogenetic analysis demonstrated close identity with viruses that had recently circulated in Mexico and Central America. Of 51 household members of 22 dengue case-patients who participated in household investigations, 6 (12%) had been recently infected with a dengue virus and reported no recent travel, suggesting intrahousehold transmission. One household member reported having a recent illness consistent with dengue. This outbreak reinforces emergence of dengue in southern Texas, particularly when incidence is high in northern Mexico. PMID:27191223

  2. Trends in clinical trials of dengue vaccine

    Directory of Open Access Journals (Sweden)

    Priya Marimuthu

    2016-01-01

    Full Text Available Dengue is one of the most important vector-borne disease and an increasing problem worldwide because of current globalization trends. Roughly, half the world′s population lives in dengue endemic countries, and nearly 100 million people are infected annually with dengue. India has the highest burden of the disease with 34% of the global cases. In the context of an expanding and potentially fatal infectious disease without effective prevention or specific treatment, the public health value of a protective vaccine is clear. There is no licensed dengue vaccine is available still, but several vaccines are under development. Keeping in view the rise in dengue prevalence globally, there is a need to increase clinical drug and vaccine research on dengue. This paper briefly reviews on the development and current status of dengue vaccine to provide information to policymakers, researchers, and public health experts to design and implement appropriate vaccine for prophylactic intervention.

  3. Points for Consideration for dengue vaccine introduction - recommendations by the Dengue Vaccine Initiative.

    Science.gov (United States)

    Lim, Jacqueline Kyungah; Lee, Yong-Seok; Wilder-Smith, Annelies; Thiry, Georges; Mahoney, Richard; Yoon, In-Kyu

    2016-01-01

    Dengue is a public health problem in the tropics and subtropics. There are several vaccine candidates in clinical development. However, there may be gaps in the new vaccine introduction after vaccine licensure before it becomes available in developing countries. In anticipation of the first dengue vaccine candidate to be licensed, Dengue Vaccine Initiative (DVI) and, its predecessor, Pediatric Dengue Vaccine Initiative (PDVI) have been working on points for consideration to accelerate evidence-based dengue vaccine introduction, once a vaccine becomes available. In this paper, we review the history of PDVI and its successor, the DVI, and elaborate on the points of consideration for dengue vaccine introduction.

  4. Host genetics and dengue fever.

    Science.gov (United States)

    Xavier-Carvalho, Caroline; Cardoso, Cynthia Chester; de Souza Kehdy, Fernanda; Pacheco, Antonio Guilherme; Moraes, Milton Ozório

    2017-12-01

    Dengue is a major worldwide problem in tropical and subtropical areas; it is caused by four different viral serotypes, and it can manifest as asymptomatic, mild, or severe. Many factors interact to determine the severity of the disease, including the genetic profile of the infected patient. However, the mechanisms that lead to severe disease and eventually death have not been determined, and a great challenge is the early identification of patients who are more likely to progress to a worse health condition. Studies performed in regions with cyclic outbreaks such as Cuba, Brazil, and Colombia have demonstrated that African ancestry confers protection against severe dengue. Highlighting the host genetics as an important factor in infectious diseases, a large number of association studies between genetic polymorphisms and dengue outcomes have been published in the last two decades. The most widely used approach involves case-control studies with candidate genes, such as the HLA locus and genes for receptors, cytokines, and other immune mediators. Additionally, a Genome-Wide Association Study (GWAS) identified SNPs associated with African ethnicity that had not previously been identified in case-control studies. Despite the increasing number of publications in America, Africa, and Asia, the results are quite controversial, and a meta-analysis is needed to assess the consensus among the studies. SNPs in the MICB, TNF, CD209, FcγRIIA, TPSAB1, CLEC5A, IL10 and PLCE1 genes are associated with the risk or protection of severe dengue, and the findings have been replicated in different populations. A thorough understanding of the viral, human genetic, and immunological mechanisms of dengue and how they interact is essential for effectively preventing dengue, but also managing and treating patients. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Controlling dengue with vaccines in Thailand.

    Directory of Open Access Journals (Sweden)

    Dennis L Chao

    Full Text Available Dengue is a mosquito-borne infectious disease that constitutes a growing global threat with the habitat expansion of its vectors Aedes aegyti and A. albopictus and increasing urbanization. With no effective treatment and limited success of vector control, dengue vaccines constitute the best control measure for the foreseeable future. With four interacting dengue serotypes, the development of an effective vaccine has been a challenge. Several dengue vaccine candidates are currently being tested in clinical trials. Before the widespread introduction of a new dengue vaccine, one needs to consider how best to use limited supplies of vaccine given the complex dengue transmission dynamics and the immunological interaction among the four dengue serotypes.We developed an individual-level (including both humans and mosquitoes, stochastic simulation model for dengue transmission and control in a semi-rural area in Thailand. We calibrated the model to dengue serotype-specific infection, illness and hospitalization data from Thailand. Our simulations show that a realistic roll-out plan, starting with young children then covering progressively older individuals in following seasons, could reduce local transmission of dengue to low levels. Simulations indicate that this strategy could avert about 7,700 uncomplicated dengue fever cases and 220 dengue hospitalizations per 100,000 people at risk over a ten-year period.Vaccination will have an important role in controlling dengue. According to our modeling results, children should be prioritized to receive vaccine, but adults will also need to be vaccinated if one wants to reduce community-wide dengue transmission to low levels.

  6. Climate and dengue transmission: evidence and implications.

    Science.gov (United States)

    Morin, Cory W; Comrie, Andrew C; Ernst, Kacey

    2013-01-01

    Climate influences dengue ecology by affecting vector dynamics, agent development, and mosquito/human interactions. Although these relationships are known, the impact climate change will have on transmission is unclear. Climate-driven statistical and process-based models are being used to refine our knowledge of these relationships and predict the effects of projected climate change on dengue fever occurrence, but results have been inconsistent. We sought to identify major climatic influences on dengue virus ecology and to evaluate the ability of climate-based dengue models to describe associations between climate and dengue, simulate outbreaks, and project the impacts of climate change. We reviewed the evidence for direct and indirect relationships between climate and dengue generated from laboratory studies, field studies, and statistical analyses of associations between vectors, dengue fever incidence, and climate conditions. We assessed the potential contribution of climate-driven, process-based dengue models and provide suggestions to improve their performance. Relationships between climate variables and factors that influence dengue transmission are complex. A climate variable may increase dengue transmission potential through one aspect of the system while simultaneously decreasing transmission potential through another. This complexity may at least partly explain inconsistencies in statistical associations between dengue and climate. Process-based models can account for the complex dynamics but often omit important aspects of dengue ecology, notably virus development and host-species interactions. Synthesizing and applying current knowledge of climatic effects on all aspects of dengue virus ecology will help direct future research and enable better projections of climate change effects on dengue incidence.

  7. Controlling Dengue with Vaccines in Thailand

    Science.gov (United States)

    Chao, Dennis L.; Halstead, Scott B.; Halloran, M. Elizabeth; Longini, Ira M.

    2012-01-01

    Background Dengue is a mosquito-borne infectious disease that constitutes a growing global threat with the habitat expansion of its vectors Aedes aegyti and A. albopictus and increasing urbanization. With no effective treatment and limited success of vector control, dengue vaccines constitute the best control measure for the foreseeable future. With four interacting dengue serotypes, the development of an effective vaccine has been a challenge. Several dengue vaccine candidates are currently being tested in clinical trials. Before the widespread introduction of a new dengue vaccine, one needs to consider how best to use limited supplies of vaccine given the complex dengue transmission dynamics and the immunological interaction among the four dengue serotypes. Methodology/Principal Findings We developed an individual-level (including both humans and mosquitoes), stochastic simulation model for dengue transmission and control in a semi-rural area in Thailand. We calibrated the model to dengue serotype-specific infection, illness and hospitalization data from Thailand. Our simulations show that a realistic roll-out plan, starting with young children then covering progressively older individuals in following seasons, could reduce local transmission of dengue to low levels. Simulations indicate that this strategy could avert about 7,700 uncomplicated dengue fever cases and 220 dengue hospitalizations per 100,000 people at risk over a ten-year period. Conclusions/Significance Vaccination will have an important role in controlling dengue. According to our modeling results, children should be prioritized to receive vaccine, but adults will also need to be vaccinated if one wants to reduce community-wide dengue transmission to low levels. PMID:23145197

  8. Entre controversias científico-médicas y movilizaciones populares. Población epidémica y vacunas contra la fiebre hemorrágica argentina 1958-1990

    Directory of Open Access Journals (Sweden)

    Agnese, Graciela

    2013-06-01

    Full Text Available The emergence and gradual extension of a new epidemic disease, as it has been the Haemorrhagic Fever Argentina, from the Decade of the ‘ 50s, prompted the medical scientific research with the aim of finding a vaccine. In the period 1959-1990 developed three projects of vaccines with different results. This article aims to consider the behavior assumed by the epidemic population around the three vaccines in response to the tensions that exist between population and physicians and researchers in charge of vaccination campaigns; the struggles between the various scientific groups; the role of the press and the State.La irrupción y la progresiva extensión de una nueva enfermedad epidémica, como ha sido la Fiebre Hemorrágica Argentina, a partir de la década del ’50, impulsó la investigación científica médica con el objetivo fundamental de encontrar una vacuna. En el período 1959-1990 se desarrollaron tres proyectos de vacunas con distintos resultados. El objetivo de este artículo es considerar las conductas asumidas por la población epidémica en torno a las tres vacunas atendiendo a las tensiones existentes entre la población y los médicos e investigadores a cargo de las campañas de vacunación; las pugnas entre los distintos grupos científicos; el rol de la prensa y del estado.

  9. Estado actual del manejo de la fiebre en niños. Current status of management of fever in children

    Directory of Open Access Journals (Sweden)

    Fabian Alberto Rueda Zambrano, MD

    2010-11-01

    Full Text Available Es muy frecuente en el ambiente médico y entre los padres de familia el uso y abuso de antipiréticos buscando disminuir abruptamente la temperatura, mejorar los síntomas derivados de la fiebre y contrarrestar las reacciones adversas de la misma. Por otro lado, existen diferentes conceptos acerca de la elección del antipirético más eficaz y seguro en niños y su ruta de administración, así como su utilidad en la prevención de convulsiones febriles, entre otras. Este artículo pretende dar claridad a las controversias en el manejo de la fiebre mediante la revisión de la literatura, incluyendo solo ensayos clínicos, meta análisis, guías de manejo y revisiones de tema, publicadas en las dos últimas décadas. Para tal fin se revisaron las bases de datos Cochrane, PubMed y Medscape.Antipyretics are very often used between physicians and parents to treat fever and relief its symptoms and prevent vaccination side effects. Indeed, there is a misconception about the prevention of recurrence of febrile seizures with antipyretics and this leads to overdoses, side effects and, therefore, more parent´s anxiety. There are contradictory concepts about the election of safer and better antipyretic in children and its better administration via: oral and rectal paracetamol, ibuprofen, ketoprofeno, nimesulide, oral and intramuscular metamizol, paracetamol plus ibuprofen and ponging/lukewarm bath. All these alternatives have been studied by many researchers without consensus because more trials with bigger samples and longer time of study are needed. No clarity exists between doctors and parents about the antipyretic's effects over febrile seizure prevention and prophylaxis of post vaccine symptoms. This article pretends to find actual evidence about fever , its implications and use of antipyretics in children through searching on data bases like PubMed, Cochcrane, and Medscape.

  10. “Programa de investigación con enfoque ecosistémico para la ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    TOSHIBA

    12 Dic 2012 ... enfermedad de Chagas y de salud Pública con comunidades Indígenas, ... monitoreo sistemático de las políticas públicas relacionadas con dengue y ... ambiental y socialmente, promuevan la equidad social y de género, y.

  11. Fiebre manchada de las montañas rocosas: ni tan manchada ni tan montañosa como pensábamos Rocky Mountain Spotted Fever: not as spotted

    Directory of Open Access Journals (Sweden)

    James Samir Díaz

    2010-12-01

    Full Text Available La fiebre manchada de las Montañas Rocosas es una infección producida por Rickettsia rickettsii, un cocobacilo polimorfo perteneciente a la familia Rickettsiaceae. A pesar de que ha pasado más de un siglo desde que fue descrita, continúa siendo una de las zoonosis más importantes en todo el mundo. Aunque los casos se presentan de manera focal y esporádica, en los últimos años se ha notado un incremento de su incidencia en los Estados Unidos y parece estar resurgiendo en varios países de Suramérica. En Colombia, poco se sabía de la enfermedad desde 1937, cuando fue descrita por primera vez, pero, en los últimos años se han presentado nuevos casos con alta tasa de mortalidad. Dado que los hallazgos clínicos y de laboratorio son inespecíficos, la fiebre manchada de las Montañas Rocosas debe incluirse en el diagnóstico diferencial de los síndromes febriles de causa no clara. A continuación se presenta una revisión de la literatura, señalando los aspectos más importantes del resurgimiento de la enfermedad en Colombia y se resaltan su etiopatogenia, manifestaciones clínicas, diagnóstico y tratamiento, con el objeto de mejorar el conocimiento local de esta infección, probablemente subdiagnosticada, que puede curarse fácilmente con unas cuantas dosis de antibióticos por vía oral.Rocky Mountain Spotted Fever (RMSF is an infection caused by Rickettsia rickettsii, a pleomorphic cocobacillae which belongs to the Rickettsiaceae family. Although it has been more than a century since its first description, this disease is still one of the most important zoonosis in the world. Usually cases occur in focal and sporadic form, but an unusual increase in the frequency of cases during the last few years has drawn the attention of surveillance systems in United States and some South American countries. Little was known about the disease in Colombia when it was first described in 1937, but in recent years new cases have been reported

  12. Is drought helping or killing dengue? Investigation of spatiotemporal relationship between dengue fever and drought

    Science.gov (United States)

    Lee, Chieh-Han; Yu, Hwa-Lung

    2015-04-01

    Dengue Fever is a vector-borne disease that is transmitted between human and mosquitos in tropical and sub-tropical regions. Previous studies have found significant relationship between the epidemic of dengue cases and climate variables, especially temperature and precipitation. Besides, the natural phenomena (e.g., drought) are considered that significantly drop the number of dengue cases by killing vector's breeding environment. However, in Kaohsiung City, Taiwan, there are evidences that the temporal pattern of dengue is correlated to drought events. Kaohsiung City experienced two main dengue outbreaks in 2002 and 2014 that both years were confirmed with serious drought. Especially in 2014, Kaohsiung City was suffered from extremely dengue outbreak in 2014 that reported the highest number of dengue cases in the history. This study constructs the spatiotemporal model of dengue incidences and index of drought events (Standardized Precipitation Index, SPI) based on the distributed lag nonlinear model (DLNM). Other meteorological measures are also included in the analysis.

  13. Could peak proteinuria determine whether patient with dengue fever develop dengue hemorrhagic/dengue shock syndrome? - A prospective cohort study

    Directory of Open Access Journals (Sweden)

    Suhail Sufi M

    2011-08-01

    Full Text Available Abstract Background Worldwide there is a need to develop simple effective predictors that can distinguish whether a patient will progress from dengue fever (DF to life threatening dengue hemorrhagic (DHF or dengue shock syndrome (DSS. We explored whether proteinuria could be used as such a marker. Methods We included patients admitted to hospital with suspected dengue fever. Starting at enrollment until discharge, each patient's daily spot urine protein creatinine ratio (UPCR was measured. We classified those with confirmed dengue infection as DF or DHF (including DSS based on WHO criteria. Peak and day of onset of proteinuria was compared between both groups. Results Compared to those with DF, patients with DHF had significantly higher median peak proteinuria levels (0.56 versus 0.08 g/day; p Conclusions Peak UPCR could potentially predict DHF in patients with dengue requiring close monitoring and treatment.

  14. Epidemiologia de la fiebre amarilla selvática en Colombia durante los últimos años

    Directory of Open Access Journals (Sweden)

    Jorge Boshell Manrique

    1944-08-01

    Full Text Available La primera manifestación de Fiebre Amarilla Selvática en los Llanos Orientales de Colombia se registro en agosto de 1934 en forma de un brote epidémico en la vecindad de la población de Restrepo, y se prolongó hasta febrero de 1935 (1. En la segunda mitad del mismo año la enfermedad apareció en los alrededores de Villavicencio y Acacías; en los últimos meses de 1936 se registraron casos en las tres regiones. Nuevas manifestaciones se presentaron en 1937 en el curso inferior de los ríos correspondientes a tales regiones, seguidas por un silencio que se prolongó hasta 1940, año en que principió el brote actual. No hubo explicación satisfactoria respecto al origen del brote de 1934. Era evidente que la infección atacaba de preferencia a los peones que trabajaban en el bosque. En ningún sitio de toda esa región, a pesar de larga y cuidadosa búsqueda, fue posible encontrar larvas o adultos de Aedes aegypti.

  15. DenguePredict: An Integrated Drug Repositioning Approach towards Drug Discovery for Dengue

    OpenAIRE

    Wang, QuanQiu; Xu, Rong

    2015-01-01

    Dengue is a viral disease of expanding global incidence without cures. Here we present a drug repositioning system (DenguePredict) leveraging upon a unique drug treatment database and vast amounts of disease- and drug-related data. We first constructed a large-scale genetic disease network with enriched dengue genetics data curated from biomedical literature. We applied a network-based ranking algorithm to find dengue-related diseases from the disease network. We then developed a novel algori...

  16. Clinical and laboratory profile of different dengue sub types in dengue virus infection

    OpenAIRE

    Niloy Gan Chaudhuri; S. Vithyavathi; K. Sankar

    2016-01-01

    Background: Dengue infection, an arthropod-borne viral hemorrhagic fever is caused by Arbovirus of Flavivirus genus and transmitted by Aedes aegypti, Aedes albopictus. Liver involvement in dengue fever is manifested by the elevation of transaminases representing reactive hepatitis, due to direct attack of virus itself or the use of hepatotoxic drugs. The objective of the study was to investigate clinical and laboratory profile of different dengue sub type's patients admitted for dengue fever....

  17. Evaluación de la definición de caso probable de dengue clásico durante el brote de dengue en Lima, 2005

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    José Juárez S

    2005-07-01

    Full Text Available Objetivos: Evaluar la utilidad diagnóstica de la definición de caso probable de dengue clásico (DCPDC para la identificación de casos definitivos, durante el brote en el distrito de Comas, abril - mayo 2005. Materiales y métodos: Estudio observacional, analítico, no controlado de corte transversal. Se incluyeron pacientes procedentes de Comas que en el periodo de estudio presentaron sospecha de dengue y con resultados de aislamiento viral o ELISA IgM, según el tiempo de enfermedad (4 ó e5 días respectivamente realizados en el Instituto Nacional de Salud. Se determinó la sensibilidad (S, especificidad (E, valor predictivo positivo (VPP y negativo (VPN de la DCPDC y de los síntomas que la conforman, tomando como prueba de oro al aislamiento viral o ELISA IgM. Resultados:Se incluyeron 316 pacientes, de los cuales se confirmaron 137 (43,4% casos de dengue. Se detectaron 60 pacientes mediante aislamiento viral, la DCPDC en pacientes con cuatro o menos días de enfermedad presentó una S=85%, E=13,40%, VPP=13,18%, VPN= 74,29%. Se detectaron 77 pacientes con cinco o más días de enfermedad con IgM ELISA, la DCPDC en este grupo presentó S= 68,42, E= 16,28, VPP= 68,42, VPN= 46,67. Conclusiones: La DCPDC aplicada en el brote de dengue en Comas, al igual que los síntomas individuales que la conforman es sensible, pero poco específico.

  18. Current management of severe dengue infection.

    Science.gov (United States)

    Lee, Tau Hong; Lee, Linda Kay; Lye, David Chien; Leo, Yee Sin

    2017-01-01

    Traditionally a disease mainly affecting the pediatric population, dengue burden has increased significantly in recent decades and adults with severe disease may become more common. There is currently no effective anti-viral agent available for the treatment of dengue and supportive care is the mainstay of management. Areas covered: We present a review of current literature on dengue severity classification systems and the management of severe dengue in adults. In particular, emphasis was placed on organ impairment in dengue and management of elderly individuals with multiple medical problems. Expert commentary: There is an urgent need to search for an effective anti-viral agent to treat infected individuals. The commercial availability of a dengue vaccine in older children has provided optimism in reducing the disease burden but long term efficacy and safety are unknown. The results from phase III trials of two new candidate vaccines are eagerly awaited.

  19. Hemophagocytic syndrome in classic dengue fever

    Directory of Open Access Journals (Sweden)

    Sayantan Ray

    2011-01-01

    Full Text Available A 24-year-old previously healthy girl presented with persistent fever, headache, and jaundice. Rapid-test anti-dengue virus IgM antibody was positive but anti-dengue IgG was nonreactive, which is suggestive of primary dengue infection. There was clinical deterioration during empiric antibiotic and symptomatic therapy. Bone marrow examination demonstrated the presence of hemophagocytosis. Diagnosis of dengue fever with virus-associated hemophagocytic syndrome was made according to the diagnostic criteria of the HLH 2004 protocol of the Histiocyte Society. The patient recovered with corticosteroid therapy. A review of literature revealed only a handful of case reports that showed the evidence that this syndrome is caused by dengue virus. Our patient is an interesting case of hemophagocytic syndrome associated with classic dengue fever and contributes an additional case to the existing literature on this topic. This case highlights the need for increased awareness even in infections not typically associated with hemophagocytic syndrome.

  20. Vírus dengue em larvas de Aedes aegypti e sua dinâmica de infestação, Roraima, Brasil Virus dengue en larvas de Aedes aegypti y su dinámica de infestación, Roraima, Brasil Dengue virus in Aedes aegypti larvae and infestation dynamics in Roraima, Brazil

    Directory of Open Access Journals (Sweden)

    Julianna Dias Zeidler

    2008-12-01

    Full Text Available OBJETIVO: Identificar a presença do vírus dengue em formas larvais de Aedes aegypti e relacionar a presença do vetor com índice pluviométrico e número de casos de dengue. MÉTODOS: Dezoito domicílios foram selecionados aleatoriamente para coleta de ovos em um bairro da cidade de Boa Vista (RR. Foram instaladas duas ovitrampas por domicílio e removidas após uma semana, mensalmente, de novembro de 2006 a maio de 2007. Foram calculados o índice de positividade de ovitrampa e o índice de densidade dos ovos. Após eclosão de 1.422 ovos coletados, foram formados 44 pools de no máximo 30 larvas para teste de presença do vírus dengue por meio de RT-PCR e hemi-nested PCR. O índice de incidência de dengue no período foi correlacionado com a precipitação pluvial. A associação entre essas variáveis e número de ovos coletados foi analisada pelo coeficiente de Pearson. RESULTADOS: Nenhum dos pools apresentou positividade para o vírus dengue, apesar do bairro ter apresentado elevados índices de incidência de dengue no período estudado. A densidade da população de Ae. aegypti aumentou conforme a pluviosidade, mas não apresentou correlação com índices de incidência de casos de dengue. CONCLUSÕES: Os resultados sugerem que a transmissão transovariana do vírus em mosquitos ocorre a uma freqüência muito baixa e por isso sua persistência em meio urbano pode não depender desse fenômeno. A população do mosquito aumentou no período de chuvas devido à formação de criadouros; a não-correlação com o índice de incidência de dengue deve-se à possibilidade desse dado ser subestimado em períodos de epidemia.OBJETIVO: Identificar la presencia del virus dengue en forma larvales de Aedes aegypti y relacionar la presencia del vector con índice pluviométrico y número de casos de dengue en el período estudiado. MÉTODOS: Dieciocho domicilios fueron seleccionados al azar para colectar huevos en una urbanización de la

  1. Post encephalitic parkinsonism following dengue viral infection

    OpenAIRE

    Bopeththa, B. V. K. M.; Ralapanawa, U.

    2017-01-01

    Background Incidence of dengue fever as well as dengue hemorrhagic fever is increasing in Sri Lanka especially among elderly population. As the number of cases is rising, rare complications of dengue illness also can be seen in clinical practice when compared to the past few years. Prompt identification and treatment of such complications is challenging due to lack of awareness and unavailability of standard treatment. Case presentation 69 years old man presented with acute onset fever and wa...

  2. CLINICAL AND LABORATORY PROFILE OF DENGUE FEVER

    Directory of Open Access Journals (Sweden)

    Farhan Fazal

    2015-02-01

    Full Text Available AIM: Dengue is a major health problem in many parts of India and Gulbarga (North Karnataka was previously not a known endemic area f or dengue. Infection with dengue virus can cause a spectrum of three clinical syndromes , classic dengue fever (DF , dengue hemorrhagic fever (DHF and dengue shock syndrome (DSS. The present study was undertaken to determine the disease profile of dengue virus infection in hospitalized patients. METHODS AND MATERIAL: One hundred patients admitted in Basaveshwar Teaching and General hospital with fever more than 38.5 degree Celsius and IgM dengue positive were selected. They were followed from the onset of fever to twelve days or till they are recovered according to WHO discharge criteria whichever is earlier. They underwent relevant investigations to identify specific organ dysfunction and categorize them into the spectrum of Dengue fever in accordance to W HO criteria . RESULTS: Out of 100 cases in this study 70 cases belongs to DF , 23 cases to DHF and 7 cases to DSS based on WHO criteria. All the cases had fever (100%. Other common symptoms noted were myalgia (61% , joint pain (54% , headache (66% , vomitin g (55% , pain abdomen (48% , rash (41% , hepatomegaly (20% , bleeding (21% and shock (8%. Hess test was positive in 24% patients. Low platelet count of less than 100 , 000/cu mm according to WHO criteria was present in 73% patients. Deranged liver functio n test and renal parameters were seen in 26 and 8 patients respectively . Mortality documented was 7 patients due to delayed presentation. The average duration of hospital stay was 4.65 days. CONCLUSION: Dengue fever was a more common manifestation than DHF or DSS. During aepidemic , dengue should be strongly considered on the differential diagnosis of any patient with fever. The treatment of dengue is mainly fluid management and supportive. Early recognition and management of alarm symptoms is the key to bet ter outcome

  3. Determinantes de la transmisión de dengue en Veracruz: un abordaje ecológico para su control

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    Escobar-Mesa Javier

    2003-01-01

    Full Text Available OBJETIVO: Identificar los factores ambientales, sociales y demográficos que contribuyen a explicar las diferencias en la transmisión de dengue en Veracruz, México, durante el periodo 1995-1998 y definir las áreas de riesgo para promover un mejor control del problema. MATERIAL Y MÉTODOS: Bajo un diseño ecológico se analizó una base de datos con el número de casos de dengue que se presentaron en 1 249 localidades en las 11 Jurisdicciones Sanitarias del estado de Veracruz durante el periodo 1995-1998. Cada una de las localidades fue identificada de acuerdo con su altitud, latitud y longitud, y con el número total de la población por sexo, el número de viviendas y la dotación de servicios públicos. Se tomó también el índice de marginación por localidad del Consejo Nacional de Población. RESULTADOS: El dengue en Veracruz se registró en 17% de las localidades y en sólo 6% de ellas se concentraron 70% de los casos de dengue en el estado. Las localidades repetidoras de dengue fueron grandes centros urbanos, con baja marginación y extensa dotación de servicios públicos. El dengue sí se transmite en las áreas rurales del estado aunque la transmisión es ocasional. El promedio de casos de dengue reportados en las localidades dependió del tamaño de la misma y del número de años que reportaron dengue durante el periodo. Se reporta un umbral poblacional para la transmisión. CONCLUSIONES: Se identificaron las localidades repetidoras de dengue que concentran 70% de los casos, y las determinantes sociales y ambientales de la transmisión. Este enfoque de riesgo puede mejorar el control y tener un impacto significativo en la prevención de la transmisión en las zonas de mayor riesgo.

  4. Dengue en el Perú: a un cuarto de siglo de su reemergencia

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    César Cabezas

    Full Text Available Un problema sanitario cada vez más frecuente y disperso en áreas tropicales y subtropicales del mundo, incluido el Perú donde ingresó en 1990, es el dengue. Es producido por el virus del dengue con cuatro serotipos y transmitido por el Aedes aegypti, vector que convive con los humanos y cuya presencia es favorecida por deficientes condiciones sanitarias, sociales y económicas. Manifestaciones de formas severas de la enfermedad como el choque y sangrado, están relacionadas con la frecuente cocirculación de los cuatro serotipos y la aparición de nuevos genotipos como el americano/asiático del serotipo 2. La nueva clasificación de la enfermedad por la OMS como dengue con o sin signos de alarma y dengue grave, está contribuyendo a un diagnóstico y tratamiento más oportunos, permitiendo reducir la letalidad. Debe destacarse la necesidad de la vigilancia del síndrome febril y los índices aédicos que contribuyan a un diagnóstico oportuno y orienten las medidas de control vectorial mediante educación sanitaria y manejo ambiental con participación comunitaria e intersectorial, de manera creativa según los nichos ecológicos. Una alternativa de prevención complementaria sería la vacunación utilizando vacunas tetravalentes cuya seguridad y eficacia deben estar garantizadas antes de su uso poblacional en el marco de estrategias integrales.

  5. Tetravalent Dengue Vaccine: A Review in the Prevention of Dengue Disease.

    Science.gov (United States)

    Scott, Lesley J

    2016-09-01

    Tetravalent, live-attenuated, dengue vaccine (Dengvaxia(®); CYD-TDV) is the first vaccine approved for the prevention of dengue disease caused by dengue virus (DENV) serotypes 1-4 in individuals aged 9-45 or 9-60 years living in high dengue endemic areas. This narrative review discusses the immunogenicity, protective efficacy, reactogenicity and safety of CYD-TDV in the prevention of dengue disease. In Latin American and Asian phase 3 trials in children and adolescents (n > 30,000), the recommended three-dose CYD-TDV regimen was efficacious in preventing virologically-confirmed dengue (VCD) during the period from 28 days after the last dose (month 13) to month 25, meeting the primary endpoint criteria. Protective efficacy against VCD in the respective individual trials was 60.8 and 56.5 % (primary analysis). During the 25-month active surveillance phase, CYD-TDV also provided protective efficacy against VCD, severe dengue, any grade of dengue haemorrhagic fever and VCD-related hospitalization in children aged 9 years and older. CYD-TDV was generally well tolerated, with no safety concerns identified after up to 4 years' follow-up (i.e. from post dose 1) in ongoing long-term studies. Based on evidence from the dengue clinical trial program, the WHO SAGE recommended that countries with high dengue endemicity consider introducing CYD-TDV as part of an integrated disease prevention strategy to lower disease burden. Pharmacoeconomic considerations will be pivotal to implementing dengue vaccination prevention strategies in these countries. The availability of a dengue vaccine is considered essential if the 2012 WHO global strategy targets for reducing the burden of dengue disease by 2020 are to be attained. Hence, CYD-TDV represents a major advance for the prevention of dengue disease in high dengue endemic regions.

  6. Dengue virus transovarial transmission by Aedes aegypti

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    Monica Dwi Hartanti

    2016-02-01

    Full Text Available Dengue is a disease that is caused by dengue virus and transmitted to humans through the bite of infected Aedes mosquitoes, especially Aedes aegypti. The disease is hyper-endemic in Southeast Asia, where a more severe form, dengue hemorrhagic fever (DHF and dengue shock syndrome (DSS, is a major public health concern. The purpose of the present study was to find evidence of dengue virus transovarial transmision in local vectors in Jakarta. Fifteen Aedes larvae were collected in 2009 from two areas in Tebet subdistrict in South Jakarta, namely one area with the highest and one with the lowest DHF prevalence. All mosquitoes were reared inside two cages in the laboratory, eight mosquitoes in one cage and seven mosquitoes in another cage and given only sucrose solution as their food. The results showed that 20% of the mosquitoes were positive for dengue virus. Dengue virus detection with an immunohistochemical method demonstrated the occurrence of transovarial transmission in local DHF vectors in Tebet subdistrict. Transovarial dengue infection in Ae.aegypti larvae appeared to maintain or enhance epidemics. Further research is needed to investigate the relation of dengue virus transovarial transmission with DHF endemicity in Jakarta.

  7. Dengue virus transovarial transmission by Aedes aegypti

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    Monica Dwi Hartanti

    2010-08-01

    Full Text Available Dengue is a disease that is caused by dengue virus and transmitted to humans through the bite of infected Aedes mosquitoes, especially Aedes aegypti. The disease is hyper-endemic in Southeast Asia, where a more severe form, dengue hemorrhagic fever (DHF and dengue shock syndrome (DSS, is a major public health concern. The purpose of the present study was to find evidence of dengue virus transovarial transmision in local vectors in Jakarta. Fifteen Aedes larvae were collected in 2009 from two areas in Tebet subdistrict in South Jakarta, namely one area with the highest and one with the lowest DHF prevalence. All mosquitoes were reared inside two cages in the laboratory, eight mosquitoes in one cage and seven mosquitoes in another cage and given only sucrose solution as their food. The results showed that 20% of the mosquitoes were positive for dengue virus. Dengue virus detection with an immunohistochemical method demonstrated the occurrence of transovarial transmission in local DHF vectors in Tebet subdistrict. Transovarial dengue infection in Ae.aegypti larvae appeared to maintain or enhance epidemics. Further research is needed to investigate the relation of dengue virus transovarial transmission with DHF endemicity in Jakarta.

  8. Dengue Fever: Causes, Complications, and Vaccine Strategies

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    Niyati Khetarpal

    2016-01-01

    Full Text Available Dengue is a highly endemic infectious disease of the tropical countries and is rapidly becoming a global burden. It is caused by any of the 4 serotypes of dengue virus and is transmitted within humans through female Aedes mosquitoes. Dengue disease varies from mild fever to severe conditions of dengue hemorrhagic fever and shock syndrome. Globalization, increased air travel, and unplanned urbanization have led to increase in the rate of infection and helped dengue to expand its geographic and demographic distribution. Dengue vaccine development has been a challenging task due to the existence of four antigenically distinct dengue virus serotypes, each capable of eliciting cross-reactive and disease-enhancing antibody response against the remaining three serotypes. Recently, Sanofi Pasteur’s chimeric live-attenuated dengue vaccine candidate has been approved in Mexico, Brazil, and Philippines for usage in adults between 9 and 45 years of age. The impact of its limited application to the public health system needs to be evaluated. Simultaneously, the restricted application of this vaccine candidate warrants continued efforts in developing a dengue vaccine candidate which is additionally efficacious for infants and naïve individuals. In this context, alternative strategies of developing a designed vaccine candidate which does not allow production of enhancing antibodies should be explored, as it may expand the umbrella of efficacy to include infants and naïve individuals.

  9. Economic Cost of Dengue in Puerto Rico

    Science.gov (United States)

    Halasa, Yara A.; Shepard, Donald S.; Zeng, Wu

    2012-01-01

    Dengue, endemic in Puerto Rico, reached a record high in 2010. To inform policy makers, we derived annual economic cost. We assessed direct and indirect costs of hospitalized and ambulatory dengue illness in 2010 dollars through surveillance data and interviews with 100 laboratory-confirmed dengue patients treated in 2008–2010. We corrected for underreporting by using setting-specific expansion factors. Work absenteeism because of a dengue episode exceeded the absenteeism for an episode of influenza or acute otitis media. From 2002 to 2010, the aggregate annual cost of dengue illness averaged $38.7 million, of which 70% was for adults (age 15+ years). Hospitalized patients accounted for 63% of the cost of dengue illness, and fatal cases represented an additional 17%. Households funded 48% of dengue illness cost, the government funded 24%, insurance funded 22%, and employers funded 7%. Including dengue surveillance and vector control activities, the overall annual cost of dengue was $46.45 million ($12.47 per capita). PMID:22556069

  10. Dengue fever outbreak: a clinical management experience.

    Science.gov (United States)

    Ahmed, Shahid; Ali, Nadir; Ashraf, Shahzad; Ilyas, Mohammad; Tariq, Waheed-Uz-Zaman; Chotani, Rashid A

    2008-01-01

    To determine the frequency of dengue as a cause of fever and compare the clinical and haematological characteristics of Dengue-probable and Dengue-proven cases. An observational study. The Combined Military Hospital, Malir Cantt., Karachi, from August 2005 to December 2006. All patients with age above 14 years, who were either hospitalized or treated in medical outdoor clinic due to acute febrile illness, were evaluated for clinical features of Dengue Fever (DF), Dengue haemorrhagic fever (DHF) and Dengue Shock Syndrome (DSS). Patients showing typical clinical features and haematological findings suggestive of Dengue fever (As per WHO criteria) were evaluated in detail for comparison of probable and confirmed cases of Dengue fever. All other cases of acute febrile illness, not showing clinical features or haematological abnormalities of Dengue fever, were excluded. The clinical and laboratory features were recorded on SPSS 11.0 programme and graded where required, for descriptive and statistical analysis. Out of 5200 patients with febrile illness, 107(2%) presented with typical features of DF, 40/107(37%) were Dengue-proven while 67/107(63%) were Dengue-probable. Out of Dengue-proven cases, 38 were of DF and 2 were of DHF. Day 1 temperature ranged from 99-1050C (mean 1010C). Chills and rigors were noticed in 86 (80%), myalgia in 67%, headache in 54%, pharyngitis in 35%, rash in 28%, and bleeding manifestations in 2% cases. Hepatomegaly in 1(0.5%), lymphadenopathy in 1(0.5%) and splenomegaly in 12 (11.2%) cases. Leucopoenia (count40 U/L in 57% cases. Frequency of clinically suspected dengue virus infection was 107 (2%), while confirmed dengue fever cases were 40 (0.8%) out of 5200 fever cases. Fever with chills and rigors, body aches, headache, myalgia, rash, haemorrhagic manifestations, platelet count, total leukocyte count, and ALT, are parameters to screen the cases of suspected dengue virus infection; the diagnosis cannot be confirmed unless supported by

  11. Chloroquine use improves dengue-related symptoms

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    Marcos Carvalho Borges

    2013-08-01

    Full Text Available Dengue is the most important arboviral disease in the world. As chloroquine, an antimalarial agent, has shown some antiviral effects, this study evaluated its effect in patients with dengue. A randomised, double-blind study was performed by administering chloroquine or placebo for three days to 129 patients with dengue-related symptoms. Of these patients, 37 were confirmed as having dengue and completed the study; in total, 19 dengue patients received chloroquine and 18 received placebo. There was no significant difference in the duration of the disease or the degree and days of fever. However, 12 patients (63% with confirmed dengue reported a substantial decrease in pain intensity and a great improvement in their ability to perform daily activities (p = 0.0004 while on the medication and the symptoms returned immediately after these patients stopped taking the medication. The same effect was not observed in patients with diseases other than dengue. Therefore, this study shows that patients with dengue treated with chloroquine had an improvement in their quality of life and were able to resume their daily activities. However, as chloroquine did not alter the duration of the disease or the intensity and days of fever, further studies are necessary to confirm the clinical effects and to assess the side effects of chloroquine in dengue patients.

  12. Tendencia en la mortalidad por fiebre reumática aguda y cardiopatía reumática crónica en Venezuela, 1955-1994

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    Isaacura César

    1998-01-01

    Full Text Available Este estudio incluye defunciones por fiebre reumática aguda (FRA y cardiopatía reumática crónica (CRC registradas en Venezuela de 1955 a 1994, según edad y sexo. Se calcularon tasas de mortalidad por 100.000 habitantes, ajustadas según método directo a la población mundial estándar de la OMS. Se produjo un descenso en la tasa ajustada de mortalidad (TAM por FR para ambos sexos de 7,68 a 1,08 (Variación Porcentual [VP] -85,9%; sexo masculino de 7,53 a 0,84 (VP -88,8% y sexo femenino de 7,83 a 1,33 (VP -83,0%. Las TAM fueron mayores en el sexo femenino. La proporción de muertes por FR sobre las producidas por enfermedades circulatorias (CIE-6 330-334,400-447; CIE-7 330-334,400-447; CIE-8 390-438; CIE-9 390-438 descendió en 88,5%. Se observó, para ambos sexos, un descenso en las TAM por FRA (VP -93,5% y CRC (VP -85,1%. El porcentaje de defunciones por FRA y CRC ocurridas en menores de 45 años mostró una tendencia ascendente. La reducción en las TAM por FR puede ser atribuible a mejoras socioeconómicas, así como a prevención con penicilina. La estabilización en las TAM a partir de 1980 podría explicarse por el deterioro socioeconómico experimentado en Venezuela y por la aparición de cepas más virulentas del EBHA.

  13. DenguePredict: An Integrated Drug Repositioning Approach towards Drug Discovery for Dengue.

    Science.gov (United States)

    Wang, QuanQiu; Xu, Rong

    2015-01-01

    Dengue is a viral disease of expanding global incidence without cures. Here we present a drug repositioning system (DenguePredict) leveraging upon a unique drug treatment database and vast amounts of disease- and drug-related data. We first constructed a large-scale genetic disease network with enriched dengue genetics data curated from biomedical literature. We applied a network-based ranking algorithm to find dengue-related diseases from the disease network. We then developed a novel algorithm to prioritize FDA-approved drugs from dengue-related diseases to treat dengue. When tested in a de-novo validation setting, DenguePredict found the only two drugs tested in clinical trials for treating dengue and ranked them highly: chloroquine ranked at top 0.96% and ivermectin at top 22.75%. We showed that drugs targeting immune systems and arachidonic acid metabolism-related apoptotic pathways might represent innovative drugs to treat dengue. In summary, DenguePredict, by combining comprehensive disease- and drug-related data and novel algorithms, may greatly facilitate drug discovery for dengue.

  14. Vigilancia epidemiológica incompleta de la epidemia de dengue-2 en Ibagué, Colombia, 1995-1997

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    Tania Camacho

    2004-06-01

    Full Text Available Desde abril de 1995 a noviembre de 1997 ocurrió una epidemia de dengue en Ibagué, Tolima (400.000 habitantes, Colombia, en la cual se notificaron 3.419 casos y se aisló virus dengue 2 en el suero de 7 pacientes. En una encuesta serológica realizada en 1996 se encontró evidencia de infección anterior por dengue en 9,6% de la población, lo cual indica que muchas infecciones no se habían reportado. Las infecciones recientes del dengue ocurrieron en todos los grupos de edad, pero los niños menores de cinco años fueron más frecuentemente infectados. 45% de éstos, que nacieron después de la reemergencia del dengue en Colombia en 1972, nunca habían sido infectados con virus del dengue. La mayoría de los casos notificados de dengue hemorrágico no satisfacían la definición actual de caso. En el estudio entomológico se encontraron larvas en el 19% de las viviendas examinadas, la mayoría de las veces de Aedes aegypti en albercas destapadas, donde muchos residentes no entendían la naturaleza doméstica del mosquito vector. El personal de salud fue entrevistado y atribuyeron la falla de los programas de control del dengue a la carencia de dirección y a otros problemas administrativos.

  15. Dengue related maculopathy and foveolitis.

    Science.gov (United States)

    Juanarita, Jaafar; Azmi, Mohd Noor Raja; Azhany, Yaakub; Liza-Sharmini, Ahmad Tajudin

    2012-09-01

    A 24 year-old Malay lady presented with high grade fever, myalgia, generalized rashes, severe headache and was positive for dengue serology test. Her lowest platelet count was 45 × 10(9) cells/L. She complained of sudden onset of painlessness, profound loss of vision bilaterally 7 days after the onset of fever. On examination, her right eye best corrected vision was 6/30 and left eye was 6/120. Her anterior segment examination was unremarkable. Funduscopy revealed there were multiple retinal haemorrhages found at posterior pole of both fundi and elevation at fovea area with subretinal fluid. Systemic examination revealed normal findings except for residual petechial rashes. She was managed conservatively. Her vision improved tremendously after 2 months. The retinal hemorrhages and foveal elevation showed sign of resolving. Ocular manifestations following dengue fever is rare. However, bilateral visual loss can occur if both fovea are involved.

  16. Blood banking e Dengue fever

    OpenAIRE

    Ramos, Estácio F.

    2008-01-01

    Dengue is an endemic/epidemic arboviral disease with a variable symptomatic benign course, but potentially fatal. Once in an inhabited area, the disease will exist forever, with the best achievement being to keep vectors suppressed and the disease under control. Tiger mosquitoes (aedes aegypti, aedes albopictus) are active breeders and urban hunters, becoming resistant to pesticides. Global warming and population growth are propelling the disease worldwide at tropical and subtropical regions,...

  17. Clinical profile and outcome of Dengue fever cases.

    Science.gov (United States)

    Ratageri, Vinod H; Shepur, T A; Wari, P K; Chavan, S C; Mujahid, I B; Yergolkar, P N

    2005-08-01

    Dengue fever is on rise globally. In India, Dengue epidemics are expanding geographically, even into the rural areas. Dengue can present with varied manifestations. The mortality rate has been brought down with high index of suspicion, strict monitoring and proper fluid resuscitation. Herewith, we are presenting clinical features and outcome of Dengue cases seen in and around Hubli (North Karnataka).

  18. A model of dengue fever

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    Boutayeb A

    2003-02-01

    Full Text Available Abstract Background Dengue is a disease which is now endemic in more than 100 countries of Africa, America, Asia and the Western Pacific. It is transmitted to the man by mosquitoes (Aedes and exists in two forms: Dengue Fever and Dengue Haemorrhagic Fever. The disease can be contracted by one of the four different viruses. Moreover, immunity is acquired only to the serotype contracted and a contact with a second serotype becomes more dangerous. Methods The present paper deals with a succession of two epidemics caused by two different viruses. The dynamics of the disease is studied by a compartmental model involving ordinary differential equations for the human and the mosquito populations. Results Stability of the equilibrium points is given and a simulation is carried out with different values of the parameters. The epidemic dynamics is discussed and illustration is given by figures for different values of the parameters. Conclusion The proposed model allows for better understanding of the disease dynamics. Environment and vaccination strategies are discussed especially in the case of the succession of two epidemics with two different viruses.

  19. Dengue NS1 Antigen - for Early Detection of Dengue Virus Infection

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    Amol Hartalkar

    2015-08-01

    Full Text Available Objectives: To evaluate the efficacy of NS1 antigen assay for early diagnosis of dengue virus infection in a tertiary care hospital. Methods: This cross sectional study was carried out in department of Medicine from August to December 2013. Total 100 patients with dengue fever were included. Complete blood count, alanine aminotransferase (ALT, aspartate aminotransferase (AST, Dengue NS1 antigen and IgM and IgG antibodies of dengue virus were done in all cases. Results: Of the 100 sera tested, 75% were positive for dengue virus infection based on dengue NS1 antigen, IgM antibody and IgG antibody. Dengue NS1 antigen and IgM, IgG antibody were able to detect dengue virus infection between day 1 to day 8 in 92% of samples, 86.7% of samples and 82.6% of samples respectively. Sixty nine percent (69% were found positive for dengue NS1 antigen, 65% were IgM positive and 62% were IgG positive. Based on the dengue NS1 antigen and IgM antibody combination, 74% were positive for dengue virus infections. Sensitivity of Dengue NS1 antigen was 92.3% and specificity of 74.28% in comparison to IgM antibody. Detection rate increased to 75%, based on the antigen and IgG antibody combination. Sensitivity of dengue NS1 antigen was 90.3% and specificity of 65.8% in comparison to IgG antibody. Conclusion: Dengue NS1 antigen is a useful, sensitive and specific test for early diagnosis of dengue virus infection and it improves diagnostic efficiency in combination with antibody test. Key words: Dengue fever, NS1 antigen. Introduction: Dengue fever (DF is the most common arboviral illness in humans. Each year, an estimated 50-100 million cases of dengue fever and 500,000 cases of dengue hemorrhagic fever occur worldwide, with 30000 deaths (mainly in children. Globally 2.5-3 billion people in approximately 112 tropical and subtropical countries are at risk of dengue.of samples respectively. Sixty nine percent (69% were found positive for dengue NS1 antigen, 65% were Ig

  20. Fiebre postoperatoria en cirugía ortopédica y urológica Postoperative fever in orthopedic and urologic surgery

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    Federico Saavedra

    2008-02-01

    Full Text Available La incidencia de fiebre en el postoperatorio varía ampliamente. En la cirugía limpia y la limpia-contaminada, la fiebre no infecciosa es más frecuente que la infecciosa. Fueron estudiados prospectivamente 303 pacientes operados en forma programada de cirugía ortopédica y urológica. Se investigó la incidencia de fiebre postoperatoria, su etiología, la relación entre el momento de su aparición y su origen y la utilidad del pedido empírico de estudios para determinar infección postoperatoria. El 14% (42/303 de los pacientes tuvieron fiebre postoperatoria. En el 81% (34/42 su etiología fue no infecciosa y en el 19% (8/42 infecciosa. Su origen fue siempre no infeccioso dentro de las primeras 48 horas del postoperatorio (pPost-operative fever incidence varies widely. In clean and clean-contaminated surgery the non-infectious fever is more frequent than the infectious fever. We performed a prospective study including 303 patients who underwent orthopedic and urologic elective surgery. The aims of our study were to investigate the incidence of post-operative fever, its etiology, the relationship between time of onset and the etiology, and the usefulness of extensive fever work-up to determine post-operative infection. The incidence of post-operative fever was 14% (42/303 of which 81% (34/42 was noninfectious and 19% (8/42 was infectious. The etiology of the fever in the first 48 hours after surgery was always non-infectious (p<0.001. An extensive fever work-up was performed in patients who presented fever only after the initial 48 hours of surgery with normal physical examination (n=19 consisting of chest x-ray, blood (2 and urine cultures. The chest x-ray was normal in all the patients, the urine cultures were positive in four cases (21%, IC 95%: 6-45 and the blood cultures in only one case (5%, IC 95%: 0.1-26. Seven patients had post-operative infections without fever as a clinical sign. The most frequently observed etiology of post

  1. De la insurrección del cuerpo a un nuevo entendimiento: La estación de fiebre de Ana Istarú

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    Jorge Chen Sham

    2015-12-01

    Full Text Available In La estación de fiebre (1983, the poet Ana Istarú rises against chauvinism, which turns the female body into the place of woman submission. In order to counterattack it, she uses two tools, marriage and virginity, so that they are invigorated by the idea of the political manifest and the possible revolution. This political function of the body enrolls the woman in an enterprise of liberation that needs to break its imprisonment in a phallocentric tradition, by exploring her own body and sexuality, for reaching a new understanding.

  2. El veneno y el mosquito: aspectos epistemológicos de la etiología y la profilaxis de la fiebre amarilla

    OpenAIRE

    Caponi,Sandra

    2000-01-01

    En el II Congreso Médico Latinoamericano (Buenos Aires, 1904) se discutieron las estrategias que Argentina y Brasil delinearon para combatir la fiebre amarilla. El análisis de la controversia entre sanitaristas brasileños y argentinos en torno a los modelos explicativos y a las estrategias de profilaxis internacional de esa enfermedad, nos permite una comprensión epistemológica de la ruptura operada por la emergencia de la medicina de los vectores. Este capítulo de la historia de la medicina ...

  3. Neurological manifestations of dengue viral infection

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    Carod-Artal FJ

    2014-10-01

    Full Text Available Francisco Javier Carod-Artal1,21Neurology Department, Raigmore hospital, Inverness, UK; 2Universitat Internacional de Catalunya (UIC, Barcelona, Spain Abstract: Dengue is the most common mosquito-borne viral infection worldwide. There is increased evidence for dengue virus neurotropism, and neurological manifestations could make part of the clinical picture of dengue virus infection in at least 0.5%–7.4% of symptomatic cases. Neurological complications have been classified into dengue virus encephalopathy, dengue virus encephalitis, immune-mediated syndromes (acute disseminated encephalomyelitis, myelitis, Guillain–Barré syndrome, neuritis brachialis, acute cerebellitis, and others, neuromuscular complications (hypokalemic paralysis, transient benign muscle dysfunction and myositis, and dengue-associated stroke. Common neuro-ophthalmic complications are maculopathy and retinal vasculopathy. Pathogenic mechanisms include systemic complications and metabolic disturbances resulting in encephalopathy, direct effect of the virus provoking encephalitis, and postinfectious immune mechanisms causing immune-mediated syndromes. Dengue viruses should be considered as a cause of neurological disorders in endemic regions. Standardized case definitions for specific neurological complications are still needed. Keywords: encephalitis, encephalopathy, dengue fever, neurological complications

  4. Social justice, climate change, and dengue.

    Science.gov (United States)

    Chang, Aileen Y; Fuller, Douglas O; Carrasquillo, Olveen; Beier, John C

    2014-06-14

    Climate change should be viewed fundamentally as an issue of global justice. Understanding the complex interplay of climatic and socioeconomic trends is imperative to protect human health and lessen the burden of diseases such as dengue fever. Dengue fever is rapidly expanding globally. Temperature, rainfall, and frequency of natural disasters, as well as non-climatic trends involving population growth and migration, urbanization, and international trade and travel, are expected to increase the prevalence of mosquito breeding sites, mosquito survival, the speed of mosquito reproduction, the speed of viral incubation, the distribution of dengue virus and its vectors, human migration patterns towards urban areas, and displacement after natural disasters. The burden of dengue disproportionately affects the poor due to increased environmental risk and decreased health care. Mobilization of social institutions is needed to improve the structural inequalities of poverty that predispose the poor to increased dengue fever infection and worse outcomes. This paper reviews the link between dengue and climatic factors as a starting point to developing a comprehensive understanding of how climate change affects dengue risk and how institutions can address the issues of social justice and dengue outbreaks that increasingly affect vulnerable urban populations. Copyright © 2014 Chang, Fuller, Carrasquillo, Beier. This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

  5. Dengue and Chikungunya Vector Control Pocket Guide

    Science.gov (United States)

    This technical guide consolidates information and procedures for surveillance and control of mosquitoes that transmit dengue and chikungunya viruses. The guide focuses on mosquitoes that transmit dengue but also makes reference to chikungunya and yellow fever because the pathogens that cause these ...

  6. Host cell responses to dengue virus infection

    NARCIS (Netherlands)

    Diosa Toro, Mayra

    2017-01-01

    Dengue (ook wel knokkelkoorts) is de meest voorkomende virale infectieziekte dat wordt overgedragen door muggen in de wereld met naar schatting 390 miljoen infecties per jaar. Ondanks de grote klinische impact en economische schade van het dengue virus is er nog steeds geen behandeling beschikbaar.

  7. [Hepatic alterations in patients with dengue].

    Science.gov (United States)

    Larreal, Yraima; Valero, Nereida; Estévez, Jesús; Reyes, Ivette; Maldonado, Mery; Espina, Luz Marina; Arias, Julia; Meleán, Eddy; Añez, German; Atencio, Ricardo

    2005-06-01

    Clinical features of Dengue are very variable due to multiple alterations induced by the virus in the organism. Increased levels of transaminases similar to those produced by the Hepatitis virus have been reported in patients with Dengue from hiperendemic zones in Asia. The objectives of this study were to determine alterations in the liver tests in patients with Dengue and to relate them to the disease, clinically and serologically. Clinical history, hemathological tests serum transaminases (ALT y AST) and bilirubin assays were performed in 62 patients with clinical and serological diagnosis of Dengue. According to clinical features 38.7% of the patients with classical (CD) and hemorrhagic (DHF) forms of Dengue reffered abdominal pain and 2 patients with DHF had ictericia and hepatomegaly. Laboratory test findings showed leucopenia in 72.5% in both forms of Dengue and of patients with DHF severe thrombocytopenia (< 50.000 platelets x mm3), long PT and PPT in 70.9%, 23.0% and 42.3%, respectively. Transaminase values five fold higher than the normal values (p < 0.005) were observed in 36.8% and 74.4% of patients with CD and DHF respectively; AST was predominant in both groups. Our results suggest liver damage during the course of Dengue. A differential diagnosis has to be done between the hepatic involvement of Dengue cases and others viral diseases with hepatic disfunctions.

  8. Recent Advances in Dengue: Relevance to Puerto Rico

    Science.gov (United States)

    Noyd, David H.; Sharp, Tyler M.

    2015-01-01

    Dengue represents an increasingly important public health challenge in Puerto Rico, with recent epidemics in 2007, 2010, and 2012–2013. Although recent advances in dengue vaccine development offer hope for primary prevention, the role of health professionals in the diagnosis and management of dengue patients is paramount. Case definitions for dengue, dengue with warning signs, and severe dengue provide a framework to guide clinical decision-making. Furthermore, the differentiation between dengue and other acute febrile illnesses, such as leptospirosis and chikungunya, is necessary for the appropriate diagnosis and management of cases. An understanding of dengue epidemiology and surveillance in Puerto Rico provides context for clinicians in epidemic and non-epidemic periods. This review aims to improve health professionals’ ability to diagnose dengue, and as highlight the relevance of recent advances in dengue prevention and management in Puerto Rico. PMID:26061055

  9. RNAi: antiviral therapy against dengue virus.

    Science.gov (United States)

    Idrees, Sobia; Ashfaq, Usman A

    2013-03-01

    Dengue virus infection has become a global threat affecting around 100 countries in the world. Currently, there is no licensed antiviral agent available against dengue. Thus, there is a strong need to develop therapeutic strategies that can tackle this life threatening disease. RNA interference is an important and effective gene silencing process which degrades targeted RNA by a sequence specific process. Several studies have been conducted during the last decade to evaluate the efficiency of siRNA in inhibiting dengue virus replication. This review summarizes siRNAs as a therapeutic approach against dengue virus serotypes and concludes that siRNAs against virus and host genes can be next generation treatment of dengue virus infection.

  10. Severe Dengue Fever Outbreak in Taiwan.

    Science.gov (United States)

    Wang, Sheng-Fan; Wang, Wen-Hung; Chang, Ko; Chen, Yen-Hsu; Tseng, Sung-Pin; Yen, Chia-Hung; Wu, Deng-Chyang; Chen, Yi-Ming Arthur

    2016-01-01

    Dengue fever (DF) is a vector-borne disease caused by dengue viruses (DENVs). Epidemic dengue occurs intermittently in Taiwan. In 2014, Taiwan experienced its largest DF outbreak. There were 15,732 DF cases reported. There were a total of 136 dengue hemorrhagic fever (DHF) cases, of which 20 resulted in death. Most DF cases were reported in southern Taiwan. A total of 15,043 (96%) cases were from Kaohsiung, a modern city in southern Taiwan. This report reviews DF epidemics in Taiwan during 2005-2014. The correlation between DF and DHF along with temperature and precipitation were conjointly examined. We conclude that most dengue epidemics in Taiwan resulted from imported DF cases. Results indicate three main factors that may have been associated with this DF outbreak in Kaohsiung: an underground pipeline explosion combined with subsequent rainfall and higher temperature. These factors may have enhanced mosquito breeding activity, facilitating DENV transmission. © The American Society of Tropical Medicine and Hygiene.

  11. Dengue fever: a Wikipedia clinical review.

    Science.gov (United States)

    Heilman, James M; De Wolff, Jacob; Beards, Graham M; Basden, Brian J

    2014-01-01

    Dengue fever, also known as breakbone fever, is a mosquito-borne infectious tropical disease caused by the dengue virus. Symptoms include fever, headache, muscle and joint pains, and a characteristic skin rash that is similar to measles. In a small proportion of cases, the disease develops into life-threatening dengue hemorrhagic fever, which results in bleeding, thrombocytopenia, and leakage of blood plasma, or into dengue shock syndrome, in which dangerously low blood pressure occurs. Treatment of acute dengue fever is supportive, with either oral or intravenous rehydration for mild or moderate disease and use of intravenous fluids and blood transfusion for more severe cases. Along with attempts to eliminate the mosquito vector, work is ongoing to develop a vaccine and medications targeted directly at the virus.

  12. Knowledge and practice regarding dengue and chikungunya

    DEFF Research Database (Denmark)

    Kajeguka, Debora C; Desrochers, Rachelle E; Mwangi, Rose

    2017-01-01

    OBJECTIVE: To investigate knowledge and prevention practices regarding dengue and chikungunya amongst community members, as well as knowledge, treatment and diagnostic practices among healthcare workers. METHOD: We conducted a cross-sectional survey with 125 community members and 125 healthcare...... good knowledge. We conducted qualitative survey (n = 40) to further assess knowledge and practice regarding dengue and chikungunya fever. RESULTS: 15.2% (n = 19) of community members had good knowledge regarding dengue, whereas 53.6%, (n = 67) of healthcare workers did. 20.3% (n = 16) of participants...... from lowland areas and 6.5% (n = 3) from highland areas had good knowledge of dengue (χ(2) = 4.25, P = 0.03). Only 2.4% (n = 3) of all participants had a good knowledge score for chikungunya. In the qualitative study, community members expressed uncertainty about dengue and chikungunya. Some healthcare...

  13. Transmission spectroscopy of dengue viral infection

    International Nuclear Information System (INIS)

    Firdous, S; Ahmed, M; Rehman, A; Nawaz, M; Anwar, S; Murtaza, S

    2012-01-01

    We presented the rapid diagnostic test for dengue infection based on light spectrum of human blood. The transmission spectra of dengue infected whole blood samples have been recorded in ultra violet to near infrared range (400 – 800 nm) of about 30 conformed infected patients and compared to normal blood samples. Transmission spectra of dengue infected blood illustrate a strong band from 400 – 600 nm with prominant peaks at 540 and 580 nm, where is in case of normal blood below 600 nm, total absorption has been observed. These prominent peaks from 400 – 600 nm are characteristics of cells damage and dangue virus antibodies immunoglobulin G (IgG) and immunoglobulin M (IgM) produced against dengue antigen. The presented diagnostic method is non invasive, cost effective, easy and fast screening technique for dengue infected patients

  14. Vitamin D serostatus and dengue fever progression to dengue hemorrhagic fever/dengue shock syndrome.

    Science.gov (United States)

    Villamor, E; Villar, L A; Lozano, A; Herrera, V M; Herrán, O F

    2017-10-01

    Vitamin D could modulate pathways leading to dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). We examined the associations of serum total 25-hydroxy vitamin D [25(OH)D] and vitamin D binding protein (VDBP) concentrations in patients with uncomplicated dengue fever (DF) with risk of progression to DHF/DSS. In a case-control study nested in a cohort of DF patients who were followed during the acute episode in Bucaramanga, Colombia, we compared 25(OH)D and VDBP at onset of fever between 110 cases who progressed to DHF/DSS and 235 DF controls who did not progress. 25(OH)D concentrations were also compared between the acute sample and a sample collected >1 year post-convalescence in a subgroup. Compared with 25(OH)D ⩾75 nmol/l, adjusted odds ratios (95% CI) for progression were 0·44 (0·22-0·88) and 0·13 (0·02-1·05) for 50 to 75 nmol/l (vitamin D insufficiency) and <50 nmol/l (vitamin D deficiency), respectively (P, trend = 0·003). Mean 25(OH)D concentrations were much lower post-convalescence compared with the acute episode, regardless of case status. Compared with controls, mean VDBP was non-significantly lower in cases. We conclude that low serum 25(OH)D concentrations in DF patients predict decreased odds of progression to DHF/DSS.

  15. Next-Generation Dengue Vaccines: Novel Strategies Currently Under Development

    OpenAIRE

    Anna P. Durbin; Stephen S. Whitehead

    2011-01-01

    Dengue has become the most important arboviral infection worldwide with more than 30 million cases of dengue fever estimated to occur each year. The need for a dengue vaccine is great and several live attenuated dengue candidate vaccines are proceeding through clinical evaluation. The need to induce a balanced immune response against all four DENV serotypes with a single vaccine has been a challenge for dengue vaccine developers. A live attenuated DENV chimeric vaccine produced by Sanofi Past...

  16. Concepciones culturales sobre el dengue en contextos urbanos de México

    Directory of Open Access Journals (Sweden)

    Caballero Hoyos Ramiro

    2006-01-01

    Full Text Available OBJETIVO: Explorar las dimensiones conceptuales del dengue en contexto urbano, a fin de generar hipótesis sobre actitudes comunitarias relacionadas a campañas preventivas. MÉTODOS: Estudio transversal exploratorio realizado entre marzo y abril de 2003 con 130 personas seleccionadas por muestreo propositivo en tres municipios con distintas prevalencias de dengue en México. Se aplicaron entrevistas semiestructuradas mediante técnicas de listados libres, sorteo de montones y triadas. Se indagaron términos asociados al dengue y grupos de dimensiones conceptuales. Se aplicó análisis de consenso mediante factorización de componentes principales y análisis dimensional mediante conglomerados jerárquicos y escalas multidimensionales. RESULTADOS: El modelo de consenso mostró alta homogeneidad en las concepciones del dengue (valores de 14.5 y 13.5 en los contextos de más prevalencia y de 5.4 en el de menor prevalencia. Las dimensiones comunes en las concepciones fueron: medidas de prevención, síntomas, causas y reservorios de Aedes aegypti (valor de verosimilitud: stress<0.28. En los tres contextos, predominó una concepción de la prevención basada en acciones públicas de autoridades sanitarias, mientras que las acciones individuales y comunitarias casi no se mencionaron. En la concepción también apareció una dimensión moral basada en una noción de higiene como mecanismo diferenciador de la comunidad cercana (limpia frente a personas y comunidades externas (sucias y enfermas. CONCLUSIÓNES: Las concepciones culturales del dengue desfavorecen la participación comunitaria autogestiva en las campañas preventivas verticales y generan barreras para la modificación de prácticas comunitarias e individuales de prevención y control.

  17. Concepciones culturales sobre el dengue en contextos urbanos de México

    Directory of Open Access Journals (Sweden)

    Ramiro Caballero Hoyos

    Full Text Available OBJETIVO: Explorar las dimensiones conceptuales del dengue en contexto urbano, a fin de generar hipótesis sobre actitudes comunitarias relacionadas a campañas preventivas. MÉTODOS: Estudio transversal exploratorio realizado entre marzo y abril de 2003 con 130 personas seleccionadas por muestreo propositivo en tres municipios con distintas prevalencias de dengue en México. Se aplicaron entrevistas semiestructuradas mediante técnicas de listados libres, sorteo de montones y triadas. Se indagaron términos asociados al dengue y grupos de dimensiones conceptuales. Se aplicó análisis de consenso mediante factorización de componentes principales y análisis dimensional mediante conglomerados jerárquicos y escalas multidimensionales. RESULTADOS: El modelo de consenso mostró alta homogeneidad en las concepciones del dengue (valores de 14.5 y 13.5 en los contextos de más prevalencia y de 5.4 en el de menor prevalencia. Las dimensiones comunes en las concepciones fueron: medidas de prevención, síntomas, causas y reservorios de Aedes aegypti (valor de verosimilitud: stress<0.28. En los tres contextos, predominó una concepción de la prevención basada en acciones públicas de autoridades sanitarias, mientras que las acciones individuales y comunitarias casi no se mencionaron. En la concepción también apareció una dimensión moral basada en una noción de higiene como mecanismo diferenciador de la comunidad cercana (limpia frente a personas y comunidades externas (sucias y enfermas. CONCLUSIÓNES: Las concepciones culturales del dengue desfavorecen la participación comunitaria autogestiva en las campañas preventivas verticales y generan barreras para la modificación de prácticas comunitarias e individuales de prevención y control.

  18. Ongoing dengue epidemic - Angola, June 2013.

    Science.gov (United States)

    2013-06-21

    On April 1, 2013, the Public Health Directorate of Angola announced that six cases of dengue had been reported to the Ministry of Health of Angola (MHA). As of May 31, a total of 517 suspected dengue cases had been reported and tested for dengue with a rapid diagnostic test (RDT). A total of 313 (60.5%) specimens tested positive for dengue, including one from a patient who died. All suspected cases were reported from Luanda Province, except for two from Malanje Province. Confirmatory diagnostic testing of 49 specimens (43 RDT-positive and six RDT-negative) at the CDC Dengue Branch confirmed dengue virus (DENV) infection in 100% of the RDT-positive specimens and 50% of the RDT-negative specimens. Only DENV-1 was detected by molecular diagnostic testing. Phylogenetic analysis indicated this virus has been circulating in the region since at least 1968, strongly suggesting that dengue is endemic in Angola. Health-care professionals throughout Angola should be aware of the ongoing epidemic, the recommended practices for clinical management of dengue patients, and the need to report cases to MHA. Persons in Angola should seek medical care for acute febrile illness to reduce the risk for developing complications. Laboratory-confirmed dengue also has been reported from seven countries on four continents among persons who had recently traveled to Luanda, including 79 persons from Portugal. Angola is the third of four African countries to report a dengue outbreak in 2013. Persons returning from Africa with acute febrile illness should seek medical care, including testing for DENV infection, and suspected cases should be reported to public health authorities.

  19. Transmisión interepidémica del dengue en la ciudad de Colima, México Interepidemic transmission of dengue in Colima City, Mexico

    Directory of Open Access Journals (Sweden)

    Francisco Espinoza-Gómez

    2003-10-01

    Full Text Available OBJETIVO: Determinar la presencia de dengue interepidémico en una comunidad infestada por Aedes aegypti, y analizar sus características epidemiológicas. MATERIAL Y MÉTODOS: Entre 2001 y 2002 se realizó un estudio probabilístico longitudinal en 245 habitantes de la ciudad de Colima, México. En cada caso se registraron: edad, sexo, nivel socioeconómico, cuadro clínico sugestivo de dengue, y se buscó la presencia de IgG e IgM antidengue por inmunocromatografía rápida y por ELISA, en un seguimiento de siete meses. Los datos se analizaron mediante tablas de contingencia y regresión de Poisson univariada. RESULTADOS: Doce individuos resultaron con infección reciente (incidencia de 1.77%; IC 95%: 0.9-3.1%, ocho de ellos refirieron cuadro clínico reciente (ji2=19.6; p=0.0001, RM: 19.6. La regresión de Poisson no reveló correlación de la infección reciente con edad, sexo, ni con nivel socioeconómico. CONCLUSIONES: En comunidades infestadas por A aegypti, como Colima, pueden ocurrir infecciones continuas por dengue sin epidemia aparente. Dichas infecciones no parecen asociarse con la edad, el sexo, ni con el nivel socioeconómico, pero sí con el cuadro clínico, el cual podría considerarse como indicador precoz de posible transmisión interepidémica.OBJECTIVE: To determine the occurrence of interepidemic dengue in a community infested with Aedes aegypti and to analyze its epidemiologic characteristics. MATERIAL AND METHODS: A longitudinal probabilistic study was carried out in Colima City between 2001 and 2002. The sample population consisted of 245 subjects. The following were recorded for each subject: sex, age, socio-economic level and dengue fever symptoms, testing for serum IgG and IgM antidengue, using quick immunochromatography as well as ELISA tests, in a seven-month follow-up period. RESULTS: Twelve individuals showed recent dengue infection (incidence: 1.77%; 95%: confidence interval 0.9-3.1%. Of these, eight had recent

  20. Resultados del examen de las primeras 5.000 muestras de higado humano obtenidas en Colombia para el estudio de fiebre amarilla

    Directory of Open Access Journals (Sweden)

    Augusto Gast Galvis

    1941-08-01

    Full Text Available Entre septiembre de 1934 y febrero de 1940 se obtuvieron en diferentes partes del país 5.000 muestras de hígado gracias al Servicio de Viscerotomía de la Sección de Estudios Especiales del Ministerio de Traabajo, Higiene y Previsión Social. Su examen reveló 196 casos de fiebre amarilla, siendo el sexo massulino el más fuertemente atacado, (186 hombres y 10 mujeres, y hallándose el mayor número de casos entre los 20 y los 29 años de edad; 555 de paludismo, 51 de atrofia amarilla, aguda, y además muchas otras lesiones de interés anatomo-patológico. Resalta la importancia de dicho servicio en el descubrimiento de brotes insospechados de fiebre amarilla que de otra manera escaparían el diagnóstico correcto, y su utilidad en el estudio de otras enfermedades que producen lesiones hepáticas características es innegables.

  1. Caracterización clínica del dengue en un hospital infantil de Cartagena (Colombia

    Directory of Open Access Journals (Sweden)

    Diana Gómez Marrugo

    2014-01-01

    Full Text Available Objetivo: Caracterizar las manifestaciones clínicas del dengue en pacientes pediátricos en una institución de salud de tercer nivel de Cartagena (Colombia. Materiales y métodos: Estudio descriptivo por revisión de historias clínicas de pacientes hospitalizados por dengue en el Hospital Infantil Napoleón Franco Pareja de la ciudad de Cartagena. Se evaluaron 136 niños con cuadros febriles agudos de etiología inaparente. Se utilizaron pruebas serológicas para confirmar la infección por el virus del dengue. Resultados: Se analizaron 98 casos de niños hospitalizados con diagnóstico de dengue. La edad osciló entre menores de 6 meses a 16 años, siendo el rango de edades con mayor frecuencia de la enfermedad de 10 a 16 años (33,7 %. Los signos y síntomas más frecuentes fueron: exantema (49,0 %, mialgia (35,7 %, cefalea (33,7 %, artralgia (33,7 %, anorexia (24,5 %, torniquete (19,4%, prurito (11,2 %, escalofrío (8,2 %, eritema facial (7,1 % y dolor retroocular (6,1 %. Conclusiones: La edad continúa siendo el factor predominante en la gravedad intrahospitalaria del dengue. Por lo tanto, se necesitan con urgencia medidas preventivas en la población pediátrica.

  2. Dengue in the Americas: challenges for prevention and control Dengue en las Américas: desafíos para su prevención y control

    Directory of Open Access Journals (Sweden)

    Héctor Gómez-Dantés

    2009-01-01

    Full Text Available Dengue is the most important vector-borne disease in the Americas and threatens the lifes of millions of people in developing countries. Imprecise morbidity and mortality statistics underestimate the magnitude of dengue as a regional health problem. As a result, it is considered a low priority by the health sector with no timely steps for effective control. Dengue is perceived as a problem of "others" (individually, collectively and institutionally, therefore responsibility for its control is passed on to others (neighbors, the community, municipality, health institutions, or other governmental agencies. With no precise risk indicators available there is little opportunity for timely diagnoses, treatment, health interventions or vector control (poor surveillance. Solutions only targeting the vector reduce the impact of interventions and there is no sustainable control. Without political commitment there are insufficient resources to face the problem. This paper discusses the challenges for prevention and control in the Americas.El dengue es la enfermedad transmitida por vector más importante en las Américas, que amenaza la vida de millones de personas. Las cifras subestiman la magnitud del problema y el dengue no figura como prioridad para las autoridades en salud y no se identifica como problema (baja percepción de riesgo, por lo que las medidas para el control se realizan tardíamente. El dengue se considera un problema de "otros" (individuo, colectividad, institucional y la responsabilidad del control se desvía hacia otros (vecindario, comunidad, municipio, el Ministerio de Salud, etc.. Se carece de indicadores de riesgo precisos, por lo que no hay oportunidad para acciones de diagnóstico, tratamiento, prevención y control vectorial. Con intervenciones poco efectivas no hay control sostenible y sin compromiso político no hay recursos suficientes para enfrentar este problema sanitario. Este artículo aborda los desafíos para la

  3. Ajuste de la fuerza de infección del dengue

    OpenAIRE

    Aldana-Bermúdez, Eliécer; Restrepo-Triviño, Maribel; Muñoz-Loaiza, Aníbal

    2017-01-01

    RESUMEN Objetivo Plantear un modelo matemático hospedero vector para el ajuste de la fuerza de infección del dengue en una población variable con crecimiento logístico y ciclo de vida del mosquito con tasa de ovoposición periódica, considerando inmunidad a un serotipo. Métodos El modelo matemático propuesto está representado por ocho ecuaciones diferenciales a las que se les calcula la fuerza de infección por el método de las redes libres de escala. Resultados Se presenta una simulación...

  4. Alergia al níquel manifestada como edema pulmonar no cardiogénico en paciente pos-cierre de comunicación interauricular con dispositivo tipo Amplatzer

    OpenAIRE

    Luis A. Gutiérrez, MD; Miller Giraldo, MD; Gilberto Estrada, MD; Luis I. Calderón, MD; Pablo Castro, MD; Edgar Hurtado, MD

    2012-01-01

    El cierre percutáneo es la modalidad predilecta para el tratamiento de los defectos septales tipo ostium secundum cuando la anatomía es favorable, y reporta una tasa de éxito excelente así como también un bajo porcentaje de complicaciones. Se presenta el caso de un cierre exitoso de defecto septal tipo ostium secundum con dispositivo tipo Amplatzer en un paciente con antecedente de alergia a metales no detectada previamente, quien presentó edema pulmonar no cardiogénico, fiebre y pericarditis...

  5. PATHOGENESIS OF HEMORRHAGIC DUE TO DENGUE VIRUS

    Directory of Open Access Journals (Sweden)

    Arief Suseno

    2015-01-01

    Full Text Available Dengue is a viral disease that is mediated by a mosquito, which causes morbidity and mortality. Viruses can increase vascular permeability which can lead to hemorrhagic diathesis or disseminated intravascular coagulation (DIC known as dengue hemorrhagic fever (DHF. In Indonesia, dengue hemorrhagic fever (DHF are caused by dengue virus infection which was found to be endemic accompanied by an explosion of extraordinary events that appear at various specified period. The diagnosis of dengue is determined based on the criteria of the World Health Organization (WHO, 1999, which are sudden high fever accompanied by a marked tendency to hemorrhage positive tourniquet test, petechiae, ecchymosis, purpura, mucosal hemorrhagic, hematemesis or melena and thrombocytopenia. The problem that still exists today is the mechanism of thrombocytopenia in patients with varying degrees of dengue involving levels of vWF (von Willebrand factor and prostaglandin I2 (PGI2 can not be explained. The mechanism of hemorrhagic in dengue virus infections acquired as a result of thrombocytopenia, platelet disfunction decreased coagulation factors, vasculopathy with endothelial injury and disseminated intravascular coagulation (DIC.

  6. Dengue situation in Brazil by year 2000

    Directory of Open Access Journals (Sweden)

    Hermann G Schatzmayr

    2000-01-01

    Full Text Available Dengue virus types 1 and 2 have been isolated in Brazil by the Department of Virology, Instituto Oswaldo Cruz, in 1986 and 1990 respectively, after many decades of absence. A successful continental Aedes aegypti control program in the Americas, has been able to eradicate the vector in most countries in the 60's, but the program could not be sustained along the years. Dengue viruses were reintroduced in the American region and the infection became endemic in Brazil, like in most Central and SouthAmerican countries and in the Caribbean region, due to the weaning of the vector control programs in these countries. High demographic densities and poor housing conditions in large urban communities, made the ideal conditions for vector spreading. All four dengue types are circulating in the continent and there is a high risk of the introduction in the country of the other two dengue types in Brazil, with the development of large epidemics. After the Cuban episode in 1981, when by the first time a large epidemic of dengue hemorrhagic fever and dengue shock syndrome have been described in the Americas, both clinical presentations are observed, specially in the countries like Brazil, with circulation of more than one dengue virus type. A tetravalent potent vaccine seems to be the only possible way to control the disease in the future, besides rapid clinical and laboratory diagnosis, in order to offer supportive treatment to the more severe clinical infections.

  7. A PATIENT DENGUE HEMORRHAGIC FEVER WITH SPASMS

    Directory of Open Access Journals (Sweden)

    Ulfa Kholili

    2014-09-01

    Full Text Available Indonesia is one of the countries with the high endemic of Dengue viral infection followed by Thailand, Myanmar, India and Srilanka. For more 10-15 years, Dengue Viral Infection/DHF has become a cause of patient who should be hospitalized and was the first cause of death children in south easthern Asia.1,2 Batavia was the first city of Indonesia found Dengue Viral infection which had been written in journal by David Bylon in the 1779. Encephalopathy of dengue (ED is one unusually complication of dengue viral infection which had been characterized by aberration the arrangement of nerves central (CNS. This paper want to describe of a young teenage with suffer from DHF and seizure. Beside it, pleural effusion and cerebral edema had been found. Seizure most likely due to dengue encephalopathy associated with cerebral edema and was supported by positive IgG and IgM anti dengue. Corticosteroid was given to improve cerebral edema. By good management as long as admission, she was discharged from hospital with a good condition.

  8. Dengue: a new challenge for neurology

    Directory of Open Access Journals (Sweden)

    Marzia Puccioni-Sohler

    2012-11-01

    Full Text Available Dengue infection is a leading cause of illness and death in tropical and subtropical regions of the world. Forty percent of the world’s population currently lives in these areas. The clinical picture resulting from dengue infection can range from relatively minor to catastrophic hemorrhagic fever. Recently, reports have increased of neurological manifestations. Neuropathogenesis seems to be related to direct nervous system viral invasion, autoimmune reaction, metabolic and hemorrhagic disturbance. Neurological manifestations include encephalitis, encephalopathy, meningitis, Guillain-Barré syndrome, myelitis, acute disseminated encephalomyelitis, polyneuropathy, mononeuropathy, and cerebromeningeal hemorrhage. The development of neurological symptoms in patients with positive Immunoglobulin M (IgM dengue serology suggests a means of diagnosing the neurological complications associated with dengue. Viral antigens, specific IgM antibodies, and the intrathecal synthesis of dengue antibodies have been successfully detected in cerebrospinal fluid. However, despite diagnostic advancements, the treatment of neurological dengue is problematic. The launch of a dengue vaccine is expected to be beneficial.

  9. DengueTools: innovative tools and strategies for the surveillance and control of dengue

    Directory of Open Access Journals (Sweden)

    Annelies Wilder-Smith

    2012-03-01

    Full Text Available Dengue fever is a mosquito-borne viral disease estimated to cause about 230 million infections worldwide every year, of which 25,000 are fatal. Global incidence has risen rapidly in recent decades with some 3.6 billion people, over half of the world's population, now at risk, mainly in urban centres of the tropics and subtropics. Demographic and societal changes, in particular urbanization, globalization, and increased international travel, are major contributors to the rise in incidence and geographic expansion of dengue infections. Major research gaps continue to hamper the control of dengue. The European Commission launched a call under the 7th Framework Programme with the title of ‘Comprehensive control of Dengue fever under changing climatic conditions’. Fourteen partners from several countries in Europe, Asia, and South America formed a consortium named ‘DengueTools’ to respond to the call to achieve better diagnosis, surveillance, prevention, and predictive models and improve our understanding of the spread of dengue to previously uninfected regions (including Europe in the context of globalization and climate change.The consortium comprises 12 work packages to address a set of research questions in three areas: Research area 1: Develop a comprehensive early warning and surveillance system that has predictive capability for epidemic dengue and benefits from novel tools for laboratory diagnosis and vector monitoring. Research area 2: Develop novel strategies to prevent dengue in children. Research area 3: Understand and predict the risk of global spread of dengue, in particular the risk of introduction and establishment in Europe, within the context of parameters of vectorial capacity, global mobility, and climate change.In this paper, we report on the rationale and specific study objectives of ‘DengueTools’. DengueTools is funded under the Health theme of the Seventh Framework Programme of the European Community, Grant

  10. DengueTools: innovative tools and strategies for the surveillance and control of dengue.

    Science.gov (United States)

    Wilder-Smith, Annelies; Renhorn, Karl-Erik; Tissera, Hasitha; Abu Bakar, Sazaly; Alphey, Luke; Kittayapong, Pattamaporn; Lindsay, Steve; Logan, James; Hatz, Christoph; Reiter, Paul; Rocklöv, Joacim; Byass, Peter; Louis, Valérie R; Tozan, Yesim; Massad, Eduardo; Tenorio, Antonio; Lagneau, Christophe; L'Ambert, Grégory; Brooks, David; Wegerdt, Johannah; Gubler, Duane

    2012-01-01

    Dengue fever is a mosquito-borne viral disease estimated to cause about 230 million infections worldwide every year, of which 25,000 are fatal. Global incidence has risen rapidly in recent decades with some 3.6 billion people, over half of the world's population, now at risk, mainly in urban centres of the tropics and subtropics. Demographic and societal changes, in particular urbanization, globalization, and increased international travel, are major contributors to the rise in incidence and geographic expansion of dengue infections. Major research gaps continue to hamper the control of dengue. The European Commission launched a call under the 7th Framework Programme with the title of 'Comprehensive control of Dengue fever under changing climatic conditions'. Fourteen partners from several countries in Europe, Asia, and South America formed a consortium named 'DengueTools' to respond to the call to achieve better diagnosis, surveillance, prevention, and predictive models and improve our understanding of the spread of dengue to previously uninfected regions (including Europe) in the context of globalization and climate change.The consortium comprises 12 work packages to address a set of research questions in three areas:Research area 1: Develop a comprehensive early warning and surveillance system that has predictive capability for epidemic dengue and benefits from novel tools for laboratory diagnosis and vector monitoring.Research area 2: Develop novel strategies to prevent dengue in children.Research area 3: Understand and predict the risk of global spread of dengue, in particular the risk of introduction and establishment in Europe, within the context of parameters of vectorial capacity, global mobility, and climate change.In this paper, we report on the rationale and specific study objectives of 'DengueTools'. DengueTools is funded under the Health theme of the Seventh Framework Programme of the European Community, Grant Agreement Number: 282589 Dengue Tools.

  11. Almanaque da Dengue: leituras e narrativas de Agentes Comunitários de Saúde Almanaque de Dengue: lecturas y narraciones de Agentes Comunitarios de Salud Dengue Almanac: readings and narratives of Community Health Agents

    Directory of Open Access Journals (Sweden)

    Helena Maria Scherlowski Leal David

    2012-12-01

    Full Text Available Apresenta-se um estudo de leitura e apropriação como metodologia de aproximação ao universo narrativo de Agentes Comunitários de Saúde (ACS, usando um dispositivo de informação e comunicação - o Almanaque da Dengue (AD. O objetivo foi o de perceber as formas de construção e apropriação de saberes sobre dengue e saúde por parte dos ACS, além de avaliar a serventia do AD como um dispositivo info-comunicacional. Foram realizadas oficinas com agentes do Rio de Janeiro, com vistas à desconstrução e leitura relacional do AD. A análise das narrativas gerou três categorias temáticas: abundância informacional nos ciclos epidêmicos; culpabilização da vítima; contradições e ambiguidades no trabalho dos ACS como mediadores. O AD mostrou-se um instrumento útil na discussão e apropriação de informações sobre a saúde, devido ao caráter textual relacional e não linear dos seus conteúdos, e ao seu formato interativo e não impositivo de formulações sobre a dengue e saúde.Presentase un estudio de lectura y apropiación como método de acercamiento al universo narrativo de los agentes comunitarios de salud (ACS, utilizando un dispositivo de información y comunicación, el Almanaque de Dengue (AD. Objetivó-se ampliar la comprensión acerca de las formas de construcción y apropiación de conocimientos sobre dengue y salud, y evaluar el Almanac como un dispositivo info-comunicacional. La metodología cualitativa se desarrolló por medio de talleres con ACS de Río de Janeiro, para la deconstrucción y lectura relacional del AD. Los resultados se clasificaron en tres temas: la abundancia de información en ciclos epidémicos, culpa de la víctima, las contradicciones y ambigüedades en la labor de la ACS. El AD ha demostrado ser una herramienta útil para el debate y la propiedad de la información de salud, debido al carácter relacional y no lineal de su contenido y su formato interactivo, no prescriptivo sobre dengue y

  12. Changing haematological parameters in dengue viral infections

    International Nuclear Information System (INIS)

    Jamil, T.; Mehmood, K.; Mujtaba, G.; Choudhry, N.

    2012-01-01

    Background: Dengue Fever is the most common arboviral disease in the world, and presents cyclically in tropical and subtropical regions of the world. The four serotypes of dengue virus, 1, 2, 3, and 4, form an antigenic subgroup of the flaviviruses (Group B arboviruses). Transmission to humans of any of these serotypes initiates a spectrum of host responses, from in apparent to severe and sometimes lethal infections. Complete Blood count (CBC) is an important part of the diagnostic workup of patients. Comparison of various finding in CBC including peripheral smear can help the physician in better management of the patient. Material and Methods: This cross sectional study was carried out on a series of suspected patients of Dengue viral infection reporting in Ittefaq Hospital (Trust). All were investigated for serological markers of acute infection. Results Out of 341 acute cases 166 (48.7%) were confirmed by IgM against Dengue virus. IgG anti-dengue was used on 200 suspected re-infected patients. Seventy-one (39.5%) were positive and 118 (59%) were negative. Among 245 confirmed dengue fever patients 43 (17.6%) were considered having dengue hemorrhagic fever on the basis of lab and clinical findings. Raised haematocrit, Leukopenia with relative Lymphocytosis and presence atypical lymphocytes along with plasmacytoid cells was consistent finding at presentation in both the patterns of disease, i.e., Dengue Haemorrhagic fever (DHF) and Dengue fever (DF). Conclusion: Changes in relative percentage of cells appear with improvement in the symptoms and recovery from the disease. These findings indicate that in the course of the disease, there are major shifts within cellular component of blood. (author)

  13. Nociones populares sobre "dengue" y "rompehuesos", dos modelos de la enfermedad en Colombia

    Directory of Open Access Journals (Sweden)

    Paulina Fajardo

    2001-09-01

    Full Text Available Objetivo. Hacer llegar a través de los niños mensajes educativos a las familias en Neiva, capital del Departamento del Huila, Colombia. Métodos. Se desarrolló un proyecto educativo para incluir en el currículo de Ciencias Naturales y Educación Ambiental de los escolares de educación básica contenidos sobre el dengue, el vector y su control. Mediante encuestas y escalas tipo Likert se determinaron los conocimientos y las actitudes en los hogares de los escolares, y luego se complementaron con entrevistas abiertas que reflejaron aspectos culturales en el campo de la salud y la forma como esta enfermedad se integra a la vida de las personas. Antes y después de la intervención, se establecieron en los hogares los índices larvarios de infestación con el vector. Resultados. Se determinó la presencia de un patrón cultural en torno a la enfermedad que supone una diferencia entre "rompehuesos" y "dengue". El "rompehuesos" corresponde al dengue clásico según el modelo popular de la enfermedad. Es aquella que puede ser afrontada con los recursos propios de la familia y la comunidad. La medicina institucional, por medio de sus organismos y agentes de salud, así como de los medios de comunicación, ha logrado superponer el otro modelo: el del dengue hemorrágico. Discusión. Se examinan las alternativas de prevención adecuadas para las condiciones en que se presenta el ciclo del vector en Neiva, los modelos de percepciones acerca de la enfermedad presentes en la comunidad y los resultados de las encuestas, que orientaron la formulación y desarrollo del programa educativo.

  14. Nociones populares sobre "dengue" y "rompehuesos", dos modelos de la enfermedad en Colombia

    Directory of Open Access Journals (Sweden)

    Fajardo Paulina

    2001-01-01

    Full Text Available Objetivo. Hacer llegar a través de los niños mensajes educativos a las familias en Neiva, capital del Departamento del Huila, Colombia. Métodos. Se desarrolló un proyecto educativo para incluir en el currículo de Ciencias Naturales y Educación Ambiental de los escolares de educación básica contenidos sobre el dengue, el vector y su control. Mediante encuestas y escalas tipo Likert se determinaron los conocimientos y las actitudes en los hogares de los escolares, y luego se complementaron con entrevistas abiertas que reflejaron aspectos culturales en el campo de la salud y la forma como esta enfermedad se integra a la vida de las personas. Antes y después de la intervención, se establecieron en los hogares los índices larvarios de infestación con el vector. Resultados. Se determinó la presencia de un patrón cultural en torno a la enfermedad que supone una diferencia entre "rompehuesos" y "dengue". El "rompehuesos" corresponde al dengue clásico según el modelo popular de la enfermedad. Es aquella que puede ser afrontada con los recursos propios de la familia y la comunidad. La medicina institucional, por medio de sus organismos y agentes de salud, así como de los medios de comunicación, ha logrado superponer el otro modelo: el del dengue hemorrágico. Discusión. Se examinan las alternativas de prevención adecuadas para las condiciones en que se presenta el ciclo del vector en Neiva, los modelos de percepciones acerca de la enfermedad presentes en la comunidad y los resultados de las encuestas, que orientaron la formulación y desarrollo del programa educativo.

  15. El Laboratorio Clínico y el Dengue

    Directory of Open Access Journals (Sweden)

    Gilberto Angel M.

    1990-12-01

    Full Text Available

    El dengue es una enfermedad endémica de zonas tropicales y subtropicales, en regiones que se encuentran por debajo de los 1.800 metros sobre el nivel del mar.

    En 1969 se registraron varios brotes en el Caribe, Puerto Rico e Islas Vírgenes y en 1970 se diagnosticó en Barranquilla. En !975 se encontraron en el Magdalena medio unos 450 casos. En 1979 se señalaron unos 3.000 casos en México y en 1981 se padeció en Cuba una gran epidemia de dengue clásico tipo 1, que afectó a 344.203 pacientes de los cuales 10.310 fueron casos severos con 158 defunciones, dentro de la clasificación de dengue hemorrágico.

    En Estados Unidos, a lo largo de la costa de México, apareció un brote endémico en otoño de 1980, transmitido por un tipo de Aedes diferente al nuestro.

    El 17 de enero de 1989 se diagnosticó en Puerto Berrío el primer caso de dengue hemorrágico en nuestro país y hasta marzo de 1990 se han diagnosticado en el Ministerio de Salud 19 casos de este tipo de dengue, que es la forma más grave, y 330 casos del dengue común, que generalmente es pasajero y no representa la gravedad del hemorrágico.

    La enfermedad es producida por un arbovirus que persiste en la naturaleza por la transmisión biológica del artrópodo hematófago Aedes aegypti. El virus se multiplica en los tejidos del artrópodo y lo inyecta al hombre, después de un período de incubación extrínseca de 8 a 12 días.

    Se conocen 4 grupos comandados por el RNA que les confiere sus características y el DNA su agresividad. Los I y II son los más agresivos y el IV, generalmente, es el más benigno.

    La primera infección deja anticuerpos e inmunidad para el tipo de virus inoculado la que es de por vida. Queda un período refractario de 2 a 4 meses para los demás. Pero no queda inmunidad definitiva para los restantes, de tal manera que a una persona no le pueden dar sino
    4 dengues.

    El virus se transmite por medio de un

  16. Dengue Haemorrhagic Fever presenting as Acute Abdomen

    OpenAIRE

    Al-Araimi, Hanaa; Al-Jabri, Amal; Mehmoud, Arshad; Al-Abri, Seif

    2011-01-01

    We describe a case of a 38 year-old Sri Lankan female who was referred to the surgeon on call with a picture of acute abdomen. She presented with a three-day history of fever, headache, abdominal pain and diarrhoea; however, the physical examination was not consistent with acute abdomen. Her platelet count was 22 ×109/L. A diagnosis of dengue haemorrhagic fever (DHF) was made and dengue serology was positive. Dengue epidemics have been associated with a variety of gastrointestinal symptoms an...

  17. Transmission Dinamics Model Of Dengue Fever

    Science.gov (United States)

    Debora; Rendy; Rahmi

    2018-01-01

    Dengue fever is an endemic disease that is transmitted through the Aedes aegypti mosquito vector. The disease is present in more than 100 countries in America, Africa, and Asia, especially tropical countries. Differential equations can be used to represent the spread of dengue virus occurring in time intervals and model in the form of mathematical models. The mathematical model in this study tries to represent the spread of dengue fever based on the data obtained and the assumptions used. The mathematical model used is a mathematical model consisting of Susceptible (S), Infected (I), Viruses (V) subpopulations. The SIV mathematical model is then analyzed to see the solution behaviour of the system.

  18. Detección por reacción en cadena de la polimerasa de transcriptasa inversa del virus de la fiebre amarilla en monos silvestres: una herramienta sensible para la vigilancia epidemiológica

    Directory of Open Access Journals (Sweden)

    Jairo A. Méndez

    2007-09-01

    Conclusión. El hallazgo del virus de la fiebre amarilla en monos silvestres representa una evidencia de su actividad enzoótica en nuestro territorio, que incrementa el riesgo de transmisión a humanos y de urbanización por procesos de migración de la población.

  19. Análise espacial da dengue e o contexto socioeconômico no município do Rio de Janeiro, RJ Análisis espacial del dengue y el contexto socioeconómico en el municipio de Rio de Janeiro, Sureste de Brasil Spatial analysis of dengue and the socioeconomic context of the city of Rio de Janeiro (Southeastern Brazil

    Directory of Open Access Journals (Sweden)

    Andréa Sobral de Almeida

    2009-08-01

    Full Text Available OBJETIVO: Analisar a epidemia de dengue em relação ao contexto socioeconômico segundo áreas geográficas. MÉTODOS: Foi realizado estudo ecológico no município do Rio de Janeiro (RJ, em áreas delimitadas como bairros, a partir de informações de casos de dengue notificados em residentes no município. Foi calculada a taxa de incidência média de dengue entre as semanas epidemiológicas: 48ª de 2001 a 20ª de 2002. A ocorrência de dengue foi correlacionada com variáveis socioeconômicas utilizando-se o coeficiente de correlação de Pearson. Utilizou-se o Índice de Moran global e local para avaliar a autocorrelação espacial da dengue e das variáveis correlacionadas significativamente com a doença. O modelo de regressão linear múltipla e o modelo espacial condicional auto-regressivo foram usados para analisar a relação entre dengue e contexto socioeconômico. RESULTADOS: Os bairros da zona oeste do município apresentaram elevadas taxas de incidência média de dengue. Apresentaram correlação significativa as variáveis: percentual de domicílios ligados à rede sanitária geral, domicílios com lavadora de roupas e densidade populacional por área urbana. O índice de autocorrelação espacial Moran revelou dependência espacial entre a dengue e variáveis selecionadas. Os modelos utilizados apontaram o percentual de domicílios ligados à rede sanitária geral como única variável associada significativamente à doença. Os resíduos de ambos os modelos revelaram autocorrelação espacial significativa, com índice de Moran positivo (pOBJETIVO: Analizar la epidemia de dengue con relación al contexto socioeconómico según áreas geográficas. MÉTODOS: Fue realizado estudio ecológico en el municipio de Río de Janeiro (Sureste de Brasil, en áreas delimitadas como urbanizaciones, a partir de informaciones de casos de dengue notificados y residentes en el municipio. Fue calculada la tasa de incidencia promedio de dengue

  20. Pielonefritis xantogranulomatosa difusa con fístula renocólica inadvertida durante más de dos años

    OpenAIRE

    Fariña Pérez, L.A.; Pesqueira Santiago, D.; Álvarez Álvarez, C.; Zungri Telo, E.R.

    2004-01-01

    INTRODUCCIÓN: Aunque la fístula renocólica es una complicación conocida de la forma difusa de la pielonefritis xantogranulomatosa, describimos un caso inusual, por la pobreza de los síntomas y la larga evolución de la enfermedad antes de ser diagnosticada. CASO CLÍNICO: Una mujer de 75 años fue vista en el Servicio de Urgencias con fiebre y malestar general. El examen y las pruebas de laboratorio mostraron una masa en el hemiabdomen izquierdo y anemia, y en la radiografía de abdomen y la tomo...

  1. Profile of dengue hepatitis in children from India and its correlation with WHO dengue case classifiation

    Directory of Open Access Journals (Sweden)

    Neelam Mohan

    2017-06-01

    Full Text Available Objective: To study the profile of liver involvement in children with dengue fever and to compare the severity of liver involvement with World Health Organization case definition. Methods: A prospective study was carried out from October 2013 to December 2014. Serologically confirmed dengue patients were grouped into three categories according to the World Health Organization classification. Groups 1 and 2 were dengue fever without and with warning signs, respectively; Group 3 was severe dengue. Biochemical and clinical profile of hepatic involvement was studied. Results: A total of 162 children with dengue fever (M:F = 2.37 were included in the study. Median (inter quartile range age was 12 years (IQR: 0.5–18 years. Hepatitis was observed in 151 (93.2% patients. Analysis revealed that out of all liver function test parameters, total bilirubin was found to be a significant predictor of dengue category two and three and albumin and ALT levels were significant predictors for category three. Eight cases presented with ALF. Their median AST was 4 817 (range 61–26 957; median ALT was 2 386 (range 39–11 100; median INR was 2.57 (range 1.6–4.2 and their median serum bilirubin was 2.95 (range 0.6–9.0. Conclusions: Some degree of hepatitis is very common in dengue infection with rise in AST being more than ALT irrespective of the severity of dengue. Severity of hepatitis correlates well with the severity of dengue and can help in triaging of dengue patients. Of all liver function parameters, total bilirubin levels correlate best with severity of dengue infection.

  2. NNDSS - Table II. Cryptosporidiosis to Dengue

    Data.gov (United States)

    U.S. Department of Health & Human Services — NNDSS - Table II. Cryptosporidiosis to Dengue - 2015.In this Table, provisional cases of selected notifiable diseases (≥1,000 cases reported during the preceding...

  3. NNDSS - Table II. Cryptosporidiosis to Dengue

    Data.gov (United States)

    U.S. Department of Health & Human Services — NNDSS - Table II. Cryptosporidiosis to Dengue - 2016. In this Table, provisional* cases of selected† notifiable diseases (≥1,000 cases reported during the preceding...

  4. Economic value of dengue vaccine in Thailand.

    Science.gov (United States)

    Lee, Bruce Y; Connor, Diana L; Kitchen, Sarah B; Bacon, Kristina M; Shah, Mirat; Brown, Shawn T; Bailey, Rachel R; Laosiritaworn, Yongjua; Burke, Donald S; Cummings, Derek A T

    2011-05-01

    With several candidate dengue vaccines under development, this is an important time to help stakeholders (e.g., policy makers, scientists, clinicians, and manufacturers) better understand the potential economic value (cost-effectiveness) of a dengue vaccine, especially while vaccine characteristics and strategies might be readily altered. We developed a decision analytic Markov simulation model to evaluate the potential health and economic value of administering a dengue vaccine to an individual (≤ 1 year of age) in Thailand from the societal perspective. Sensitivity analyses evaluated the effects of ranging various vaccine (e.g., cost, efficacy, side effect), epidemiological (dengue risk), and disease (treatment-seeking behavior) characteristics. A ≥ 50% efficacious vaccine was highly cost-effective [GDP) ($4,289)] up to a total vaccination cost of $60 and cost-effective [GDP ($12,868)] up to a total vaccination cost of $200. When the total vaccine series was $1.50, many scenarios were cost saving.

  5. Dengue e dengue hemorrágico: aspectos do manejo na unidade de terapia intensiva Dengue and dengue hemorrhagic fever: management issues in an intensive care unit

    Directory of Open Access Journals (Sweden)

    Sunit Singhi

    2007-05-01

    Full Text Available OBJETIVOS: Descrever a epidemiologia, as características clínicas e o tratamento do dengue e das síndromes do choque associadas ao dengue. FONTES DOS DADOS: Para esta revisão de literatura, foi feita uma pesquisa no Pubmed e nos websites da Organização Mundial da Saúde (OMS e OPAS usando os termos dengue e síndrome do choque associada ao dengue. A informação foi complementada com a experiência pessoal dos autores. SÍNTESE DOS DADOS: O dengue é a mais importante doença viral transmitida por artrópodos em seres humanos. A doença se manifesta de diversas formas, variando desde uma síndrome viral não-diferenciada até febre hemorrágica e choque grave. O dengue é uma enfermidade autolimitada, não específica, caracterizada por febre, cefaléia, mialgia, e sintomas constitucionais. As formas mais graves (febre hemorrágica e síndrome do choque podem levar a um comprometimento multissistêmico e ao óbito. O diagnóstico precoce e um acompanhamento contínuo do agravamento e da resposta ao tratamento são necessários em todos os casos. A OMS recomenda uma abordagem escalonada para o manejo, adequada para as formas mais leves e para o choque precoce. Nas formas mais graves, é preciso uma abordagem agressiva de reanimação com fluidos e de suporte à falência de órgãos em pacientes em estado crítico. As pesquisas sobre as diferenças fisiopatológicas entre o choque do dengue e o choque séptico, seleção de fluidos, agentes inotrópicos e técnicas de suporte a órgãos podem beneficiar os pacientes em estado crítico. CONCLUSÕES: Não há uma terapia específica para infecções causadas pelo dengue. Um bom tratamento de suporte pode salvar vidas mas, em última análise, as iniciativas de controle do vetor e de prevenção contra picadas do mosquito podem trazer os maiores benefícios.OBJECTIVES: To describe the epidemiology, clinical features and treatment of dengue fever and dengue shock syndrome. SOURCES: To prepare

  6. Dengue: an update on treatment options.

    Science.gov (United States)

    Chan, Candice Y Y; Ooi, Eng Eong

    2015-01-01

    Dengue is the most important mosquito-borne viral pathogen globally, with approximately 100 million cases of acute dengue annually. Infection can result in severe, life-threatening disease. Currently, there is no effective vaccine or licensed antiviral. Management is primarily supportive with fluids. Direct antiviral therapies that reduce dengue severity could be useful although these would need to inhibit all four viral serotypes effectively. This review focuses on the interventions that currently considered the gold standard in case management as well as exploratory therapies that have been studied in clinical trials. Although antiviral drug and therapeutic antibodies for dengue remain a work in progress, these studies have produced some promising results and may have the potential to be future drugs.

  7. NNDSS - Table II. Cryptosporidiosis to Dengue

    Data.gov (United States)

    U.S. Department of Health & Human Services — NNDSS - Table II. Cryptosporidiosis to Dengue - 2017. In this Table, provisional cases of selected notifiable diseases (≥1,000 cases reported during the preceding...

  8. Dengue Fever in the United States

    Centers for Disease Control (CDC) Podcasts

    Dr. Amesh Adalja, an associate at the Center for Biosecurity and clinical assistant professor at the University of Pittsburgh School, of Medicine, discusses dengue fever outbreaks in the United States.

  9. Pathogenesis of Dengue Vaccine Viruses in Mosquitoes.

    Science.gov (United States)

    1980-01-01

    1973). Sabin (1948) showed that attenuated dpngiie, passed through mosquitoes, did not revert to pathogenicity frnr man. -7- Thus even if the vaccine ...AD-A138 518 PATHOGENESIS OF DENGUE VACCINE YIRUSES IN MOSQUITOES 1/ (U) YALE UNIV NEW HAVEN CONN SCHOOL OF MEDICINE B J BEATY ET AL. 9i JAN 80 DRND7...34 ’ UNCLASSIFIED 0{) AD 0Pathogenesis of dengue vaccine viruses in mosquitoes -First Annual Report Barry I. Beaty, Ph.D. Thomas H. G

  10. A Rapporteur's Summary : Research on Dengue Vaccine

    OpenAIRE

    Kitamura, Takashi

    1994-01-01

    Dengue virus is a member of flavivirus group. Diseases caused by flaviviruses have been a scourge of mankind for long history of human kind; with yellow fever at the top, followed by dengue fever, Japanese encephalitis (JE) and Russian spring-summer encephalitis (RSSE). Due to the dvevelopment of a safe and efficacious live-attenuated vaccine against yellow fever as a first laboratory-designed virus vaccine, this disease is no longer a threat in countries where adequate vaccination is practic...

  11. Acute atrial fibrillation during dengue hemorrhagic fever

    Directory of Open Access Journals (Sweden)

    Henrique Horta Veloso

    Full Text Available Dengue fever is a viral infection transmitted by the mosquito, Aedes aegypti. Cardiac rhythm disorders, such as atrioventricular blocks and ventricular ectopic beats, appear during infection and are attributed to viral myocarditis. However, supraventricular arrhythmias have not been reported. We present a case of acute atrial fibrillation, with a rapid ventricular rate, successfully treated with intravenous amiodarone, in a 62-year-old man with dengue hemorrhagic fever, who had no structural heart disease.

  12. Acute atrial fibrillation during dengue hemorrhagic fever

    Directory of Open Access Journals (Sweden)

    Veloso Henrique Horta

    2003-01-01

    Full Text Available Dengue fever is a viral infection transmitted by the mosquito, Aedes aegypti. Cardiac rhythm disorders, such as atrioventricular blocks and ventricular ectopic beats, appear during infection and are attributed to viral myocarditis. However, supraventricular arrhythmias have not been reported. We present a case of acute atrial fibrillation, with a rapid ventricular rate, successfully treated with intravenous amiodarone, in a 62-year-old man with dengue hemorrhagic fever, who had no structural heart disease.

  13. An expanded dengue syndrome patient with manifestation myocarditis: case report

    Science.gov (United States)

    Arifijanto, M. V.; Luqmana, H. P.; Rusli, M.; Bramantono

    2018-03-01

    Dengue infection may manifest asymptomatic, dengue fever, dengue hemorrhagic fever, dengue shock syndrome. However, atypical manifestations in other organs have been increasingly reported and called expanded dengue syndrome. One of the cardiac complications in dengue is myocarditis. An 18-year-old woman complains of high fever since 3 days, epistaxis, chest pain, dyspnea, and vomiting. Laboratory examination obtained thrombocytopenia, hemoconcentration, NS1, IgG-IgM dengue positive, CKMB and Troponin- I increase. Electrocardiogram result ischemic anterior-posterior. Echocardiography results hyperechogenic on myocardial suspicious a myocarditis. The patient was diagnosed with acute myocarditis and dengue hemorrhagic fever. Condition improved after five days of treatment. Cardiac complications in dengue are now increasingly observed with the most common case is myocarditis. The main mechanism of dengue myocarditis is still unknown though both direct viral infection and immune mediated damage have been suggested to be the cause of myocardial damage. The low incidence of dengue myocarditis is because it’s asymptomatic and diagnosis is easily missed. Almost all cases of dengue myocarditis are self-limiting and severe myocarditis leading to dilated cardiomyopathy is extremely rare. There have been reported a patient with dengue hemorrhagic fever with manifestation myocarditis. Condition improve with supportive management.

  14. Pediatric ischemic stroke due to dengue vasculitis.

    Science.gov (United States)

    Nanda, Subrat Kumar; Jayalakshmi, Sita; Mohandas, Surath

    2014-10-01

    Dengue infection is an important arboviral infection in southeast Asia, especially in India. Neurological manifestations of dengue are increasingly recognized. We report an ischemic stroke due to dengue vasculitis in an 8-year-old child. We present a girl with a short febrile illness followed by episodic severe headache, with gradually progressive hemiparesis and visual impairment. Her brain magnetic resonance imaging revealed multiple infarctions in the anterior and posterior circulation. The magnetic resonance angiogram revealed irregular narrowing of bilateral middle cerebral arteries, right anterior cerebral artery, left posterior cerebral, and bilateral vertebral arteries suggestive of vasculitis. Her dengue serology was strongly positive for immunoglobulin M with 68.9 panbio units. The rest of the evaluation for pediatric stroke was unremarkable. She was treated with intravenous followed by oral corticosteroids and recovered totally with resolution of vasculitis on magnetic resonance angiogram over the next 3 months. This child illustrates possible immune-mediated vasculitis caused by dengue infection which is rather a rare presentation in a child who subsequently recovered well. One should consider dengue in childhood strokes in endemic regions. Copyright © 2014 Elsevier Inc. All rights reserved.

  15. The effects of urban growth on dengue

    Directory of Open Access Journals (Sweden)

    Marco Aurélio Pereira Horta

    2014-09-01

    Full Text Available Objective: To analyze the spatial and temporal dynamics of dengue in Coronel Fabriciano, Minas Gerais State, Brazil, and to associate cases to the growth of urban areas and loss of natural areas in recent years. Methods: This is a descriptive, exploratory study, with a quantitative approach. Dengue cases of 2009 were obtained from the Health Municipal Secretariat, including the suspected and confirmed cases. Shape files were obtained, containing information about the municipal boundary, boundary of the urban area, census tracts, areas with buildings and natural areas. Based on the distribution of dengue cases, the Kernel estimator was used to measure data dispersion. Results: Dengue cases reported were georeferenced in GIS (Geographic Information System environment. The landscape showed changes in the units of urban area and pasture, as an urban growth over the pasture matrix. No changes were observed in the areas of remaining forest and eucalyptus. There are cases spatially spread with a tendency to form clusters. Conclusion: Cases of dengue were observed spatially clustered in the northern region of the city, where new neighborhoods have emerged in recent years, following the population growth without proper structure of urbanization and urban planning. In addition, urban growth have reduced the margin of watercourses providing a bare soil, suitable for accumulation of trash and formation of breeding sites for mosquitoes. Efficient public policies and appropriate urban planning might reduce the impact of dengue in endemic regions. doi: http://dx.doi.org/10.5020/18061230.2013.p539

  16. Peptides as Therapeutic Agents for Dengue Virus.

    Science.gov (United States)

    Chew, Miaw-Fang; Poh, Keat-Seong; Poh, Chit-Laa

    2017-01-01

    Dengue is an important global threat caused by dengue virus (DENV) that records an estimated 390 million infections annually. Despite the availability of CYD-TDV as a commercial vaccine, its long-term efficacy against all four dengue virus serotypes remains unsatisfactory. There is therefore an urgent need for the development of antiviral drugs for the treatment of dengue. Peptide was once a neglected choice of medical treatment but it has lately regained interest from the pharmaceutical industry following pioneering advancements in technology. In this review, the design of peptide drugs, antiviral activities and mechanisms of peptides and peptidomimetics (modified peptides) action against dengue virus are discussed. The development of peptides as inhibitors for viral entry, replication and translation is also described, with a focus on the three main targets, namely, the host cell receptors, viral structural proteins and viral non-structural proteins. The antiviral peptides designed based on these approaches may lead to the discovery of novel anti-DENV therapeutics that can treat dengue patients.

  17. Dengue mortality in Colombia, 1985-2012.

    Science.gov (United States)

    Chaparro-Narváez, Pablo; León-Quevedo, Willian; Castañeda-Orjuela, Carlos Andrés

    2016-02-11

    Dengue in Colombia is an important public health problem due to the huge economic and social costs it has caused, especially during the disease outbreaks.  To describe the behavior of dengue mortality in Colombia between 1985 and 2012.  We conducted a descriptive study. Information was obtained from mortality and population projection databases provided by the Departamento Administrativo Nacional de Estadística (DANE) for the 1985-2012 period. Mortality rates, rate ratios, and case fatality rates were estimated.  A total of 1,990 dengue deaths were registered during this period in Colombia. Dengue mortality rates presented an increasing trend with statistical significance between 1985 and 1998. Higher mortality rates were reported in men both younger than 5 years and older than 65 years. Between 1995 and 2012, category 1 to 4 municipalities reported the highest mortality rates. Case fatality rates varied during the period between 0.01% and 0.39%.  Dengue is an avoidable disease that should disappear from mortality statistics as a cause of death. The event is avoidable if the proposed activities from the Estrategia de Gestión Integrada (EGI)-Dengue are implemented and evaluated. We recommend encouraging the development of an informational culture to contribute to decision making and prioritizing resource allocation.

  18. Facing dengue fever - our first experience

    Directory of Open Access Journals (Sweden)

    Cvjetković Dejan

    2017-01-01

    Full Text Available Introduction. Dengue fever is a mosquito-borne disease caused by dengue virus, endemic in tropical and subtropical regions, where it is mostly imported from. The most common clinical form is classic dengue fever. We presented the first dengue case microbiologically confirmed in Serbia. Case report. A 34-year-old male got classic dengue fever after arrival from Cuba. The disease occurred suddenly with fever, myalgias, skin rash, hepatosplenomegaly, cytopenia, abnormal aminotransferase and creatine kinase levels. The diagnosis was confirmed with virological diagnostic methods. Significant leukopenia and thrombocytopenia as well as elevation of serum creatine kinase activity were recorded from the very beginning of hospitalization, but were gradually normalized. The whole duration of hospitalization was accompanied by laboratory signs of liver lesion. The disease had favourable outcome. At hospital discharge, the patient was afebrile, asymptomatic, with discrete erythematous rash on torso and arms, normal hemathological values and creatine kinase level and moderately elevated alanine-aminotransferase level. Conclusion. Considering global climate changes and growing international traffic, our health care service needs to be ready for possible massive outbreaks of dengue and other tropical infectious diseases in forthcoming years.

  19. Seropositivity of Dengue Antibodies during Pregnancy

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    Nor Azlin Mohamed Ismail

    2014-01-01

    Full Text Available Purpose. Malaysia a dengue endemic country with dengue infections in pregnancy on the rise. The present study was aimed at determining dengue seroprevalence (IgG or IgM during pregnancy and its neonatal transmission in dengue seropositive women. Methods. Maternal with paired cord blood samples were tested for dengue antibodies (IgG and IgM using an enzyme-linked immunosorbent assay (ELISA. Maternal age, parity, occupation, ethnic group, and gestational age were recorded. Data on neonatal Apgar score and admissions to the Neonatal Intensive Care Unit (NICU were analyzed. Results. Out of 358 women recruited, about 128 (35.8% patients were seropositive. Twelve patients (3.4% had recent infections (IgM positive and another 116 women (32.4% were with past infections (IgG positive. All babies born to seropositive mothers had positive IgG paired cord blood; however, no IgM seropositivity was observed. All neonates had good Apgar scores and did not require NICU admission. Conclusion. In this study, 35.8% pregnant women were found to be dengue seropositive. However, transplacental transfer of IgG antibodies had no detrimental effect on the neonatal outcomes.

  20. Seroprevalencia del dengue en el distrito de Casma. Ancash, Perú 2002

    Directory of Open Access Journals (Sweden)

    Jorge Gómez B

    2005-07-01

    Full Text Available Objetivos: Evaluar la magnitud de la infección por el virus del dengue después del primer brote presentado en el distrito de Casma, Ancash (febrero - abril 2002. Materiales y métodos: Se realizó un estudio seroepidemiológico postepidémico, se procesaron 400 muestras de sangre total recolectados en papel de filtro, las que fueron obtenidas por muestreo probabilístico, bietápico y de conglomerados en población del distrito de Casma. Se consideró como positivo a todo paciente con resultado positivo del ELISA de captura para IgM e IgG para dengue. Resultados: La prevalencia de infección en base a la encuesta seroepidemiológica encontrada fue de 14,1% (IC 95% 9,8 - 18,4%, por lo que se estima se presentaron 3939 (I.C.95% 2723- 5113 infecciones por el virus del dengue serotipo 1 en el distrito de Casma durante la epidemia de febrero a mayo del año 2002. El 60% de los casos positivos presentó sintomatología, el sistema de vigilancia epidemiológica notificó sólo 832 casos de dengue clásico, sin presentación de formas graves. Conclusiones: La seroprevalencia del primer brote de dengue en Casma en abril del año 2002 fue de 14,1%. El sistema de notificación obligatoria de la vigilancia epidemiológica detectó 21% del total estimado de personas infectadas (aproximadamente 1:5; y 35,2% de los casos que tuvieron sintomatología.

  1. Performance Evaluation of Commercial Dengue Diagnostic Tests for Early Detection of Dengue in Clinical Samples

    Directory of Open Access Journals (Sweden)

    Tuan Nur Akmalina Mat Jusoh

    2017-01-01

    Full Text Available The shattering rise in dengue virus infections globally has created a need for an accurate and validated rapid diagnostic test for this virus. Rapid diagnostic test (RDT and reverse transcription-polymerase chain reaction (RT-PCR diagnostic detection are useful tools for diagnosis of early dengue infection. We prospectively evaluated the diagnostic performance of nonstructural 1 (NS1 RDT and real-time RT-PCR diagnostic kits in 86 patient serum samples. Thirty-six samples were positive for dengue NS1 antigen while the remaining 50 were negative when tested with enzyme-linked immunosorbent assay (ELISA. Commercially available RDTs for NS1 detection, RTK ProDetect™, and SD Bioline showed high sensitivity of 94% and 89%, respectively, compared with ELISA. GenoAmp® Trioplex Real-Time RT-PCR and RealStar® Dengue RT-PCR tests presented a comparable kappa agreement with 0.722. The result obtained from GenoAmp® Real-Time RT-PCR Dengue test showed that 14 samples harbored dengue virus type 1 (DENV-1, 8 samples harbored DENV-2, 2 samples harbored DENV-3, and 1 sample harbored DENV-4. 1 sample had a double infection with DENV-1 and DENV-2. The NS1 RDTs and real-time RT-PCR tests were found to be a useful diagnostic for early and rapid diagnosis of acute dengue and an excellent surveillance tool in our battle against dengue.

  2. Dengue in Bali: Clinical characteristics and genetic diversity of circulating dengue viruses.

    Science.gov (United States)

    Megawati, Dewi; Masyeni, Sri; Yohan, Benediktus; Lestarini, Asri; Hayati, Rahma F; Meutiawati, Febrina; Suryana, Ketut; Widarsa, Tangking; Budiyasa, Dewa G; Budiyasa, Ngurah; Myint, Khin S A; Sasmono, R Tedjo

    2017-05-01

    A high number of dengue cases are reported annually in Bali. Despite the endemicity, limited data on dengue is available for Bali localities. Molecular surveillance study was conducted to explore the clinical and virological characteristics of dengue patients in urban Denpasar and rural Gianyar areas in Bali during the peak season in 2015. A total of 205 adult dengue-suspected patients were recruited in a prospective cross-sectional study. Demographic and clinical information were obtained, and dengue screening was performed using NS1 and IgM/IgG ELISAs. Viral RNA was subsequently extracted from patients' sera for serotyping using conventional RT-PCR and Simplexa Dengue real-time RT-PCR, followed by genotyping with sequencing method. We confirmed 161 patients as having dengue by NS1 and RT-PCR. Among 154 samples successfully serotyped, the DENV-3 was predominant, followed by DENV-1, DENV-2, and DENV-4. Serotype predominance was different between Denpasar and Gianyar. Genotyping results classify DENV-1 isolates into Genotype I and DENV-2 as Cosmopolitan Genotype. The classification grouped isolates into Genotype I and II for DENV-3 and DENV-4, respectively. Clinical parameters showed no relationship between infecting serotypes and severity. We observed the genetic diversity of circulating DENV isolates and their relatedness with historical data and importation to other countries. Our data highlights the role of this tourist destination as a potential source of dengue transmission in the region.

  3. Non-HLA gene polymorphisms and their implications on dengue ...

    African Journals Online (AJOL)

    Harapan Harapan

    2012-09-23

    controlled immuno- logical responses. Genetic variants involved in viral entry, replication and innate immunity pathways play an important role in the causal pathway of dengue hemorrhagic fever/dengue shock syndrome.

  4. International Dengue Vaccine Communication and Advocacy: Challenges and Way Forward.

    Science.gov (United States)

    Carvalho, Ana; Van Roy, Rebecca; Andrus, Jon

    2016-01-01

    Dengue vaccine introduction will likely occur soon. However, little has been published on international dengue vaccine communication and advocacy. More effort at the international level is required to review, unify and strategically disseminate dengue vaccine knowledge to endemic countries' decision makers and potential donors. Waiting to plan for the introduction of new vaccines until licensure may delay access in developing countries. Concerted efforts to communicate and advocate for vaccines prior to licensure are likely challenged by unknowns of the use of dengue vaccines and the disease, including uncertainties of vaccine impact, vaccine access and dengue's complex pathogenesis and epidemiology. Nevertheless, the international community has the opportunity to apply previous best practices for vaccine communication and advocacy. The following key strategies will strengthen international dengue vaccine communication and advocacy: consolidating existing coalitions under one strategic umbrella, urgently convening stakeholders to formulate the roadmap for integrated dengue prevention and control, and improving the dissemination of dengue scientific knowledge.

  5. Peripheral gangrene in a case of severe dengue

    African Journals Online (AJOL)

    ergot alkaloids or other related medications. ... The spectrum of disease manifestations in dengue fever is wide. ... dengue shock syndrome and multiorgan failure. .... McGouran RC, Emmerson GA. Symmetrical peripheral gangrene. Br Heart J.

  6. Epidemiological trends of dengue in mainland China, 2005–2015

    Directory of Open Access Journals (Sweden)

    Jimin Sun

    2017-04-01

    Conclusions: Although the number of dengue cases has increased and the affected areas have expanded in recent years, dengue is still an imported disease and does not present an endemic trend in mainland China.

  7. Rare case of acute dengue encephalitis with correlated MRI findings

    International Nuclear Information System (INIS)

    Mathew, Rishi Philip; Basti, Ram Shenoy; Hegde, Pavan; Devdas, Jaidev M.; Khan, Habeeb Ullah; Bukelo, Mario Joseph

    2014-01-01

    Dengue encephalitis is extremely rare, with most patients showing no significant abnormality on neuroimaging (CT/MRI). We report one of the very few documented cases of dengue encephalitis, with abnormal signal intensities on all major sequences on brain MRI.

  8. Etmoiditis complicada con celulitis orbitaria en un lactante

    Directory of Open Access Journals (Sweden)

    Odette Pantoja Pereda

    Full Text Available Se define la etmoiditis como la inflamación e infección de la mucosa de las celdas etmoidales. Se diagnostica clínicamente con la presencia de edema en el ángulo medial del ojo, que se extiende a las estructuras adyacentes. Estudios imagenológicos son necesarios para verificar la presencia de complicaciones, entre las que se citan el absceso orbitario, subperióstico, epidural, subdural, cerebral, tromboflebitis del seno cavernoso, meningoencefalitis y la muerte del paciente. Streptococcus pneumoniae, Staphylococcus aureus y Haemophilus influenzae son microorganismos frecuentemente responsables de este cuadro. Las complicaciones orbitarias en las etmoiditis, necesitan el diagnóstico y tratamiento precoz para evitar secuelas irreversibles. Se presenta el caso de un lactante masculino, de 1 mes y 26 días de nacido, que ingresa con fiebre, rinorrea serosa y rechazo al alimento. Evolutivamente se constata marcada obstrucción nasal, edema periorbitario izquierdo, rubor, calor, protrusión del globo ocular e irritabilidad, y se diagnostica etmoiditis complicada con celulitis orbitaria. Se realiza tomografía axial computarizada que informa seno etmoidal izquierdo ocupado por contenido de densidad líquida con celularidad (15-25 UH, engrosamiento de partes blandas de la pared interna de la órbita que abomba, comprime y desplaza la musculatura orbitaria, y se extiende al párpado y al ala izquierda de la nariz desviando tabique blando; así como ligera proptosis, y disminución de la densidad ósea de la pared interna de la cavidad orbitaria. Se toma muestra para cultivo y se aísla Staphylococcus aureus meticillin resistente. Se comentan los elementos diagnósticos y su tratamiento, con el objetivo de llamar la atención de los pediatras para lograr el diagnóstico y tratamiento oportuno.

  9. Stochastic dynamics of dengue epidemics.

    Science.gov (United States)

    de Souza, David R; Tomé, Tânia; Pinho, Suani T R; Barreto, Florisneide R; de Oliveira, Mário J

    2013-01-01

    We use a stochastic Markovian dynamics approach to describe the spreading of vector-transmitted diseases, such as dengue, and the threshold of the disease. The coexistence space is composed of two structures representing the human and mosquito populations. The human population follows a susceptible-infected-recovered (SIR) type dynamics and the mosquito population follows a susceptible-infected-susceptible (SIS) type dynamics. The human infection is caused by infected mosquitoes and vice versa, so that the SIS and SIR dynamics are interconnected. We develop a truncation scheme to solve the evolution equations from which we get the threshold of the disease and the reproductive ratio. The threshold of the disease is also obtained by performing numerical simulations. We found that for certain values of the infection rates the spreading of the disease is impossible, for any death rate of infected mosquitoes.

  10. Impact of Dengue Vaccination on Serological Diagnosis: Insights From Phase III Dengue Vaccine Efficacy Trials.

    Science.gov (United States)

    Plennevaux, Eric; Moureau, Annick; Arredondo-García, José L; Villar, Luis; Pitisuttithum, Punnee; Tran, Ngoc H; Bonaparte, Matthew; Chansinghakul, Danaya; Coronel, Diana L; L'Azou, Maïna; Ochiai, R Leon; Toh, Myew-Ling; Noriega, Fernando; Bouckenooghe, Alain

    2018-04-03

    We previously reported that vaccination with the tetravalent dengue vaccine (CYD-TDV; Dengvaxia) may bias the diagnosis of dengue based on immunoglobulin M (IgM) and immunoglobulin G (IgG) assessments. We undertook a post hoc pooled analysis of febrile episodes that occurred during the active surveillance phase (the 25 months after the first study injection) of 2 pivotal phase III, placebo-controlled CYD-TDV efficacy studies that involved ≥31000 children aged 2-16 years across 10 countries in Asia and Latin America. Virologically confirmed dengue (VCD) episode was defined with a positive test for dengue nonstructural protein 1 antigen or dengue polymerase chain reaction. Probable dengue episode was serologically defined as (1) IgM-positive acute- or convalescent-phase sample, or (2) IgG-positive acute-phase sample and ≥4-fold IgG increase between acute- and convalescent-phase samples. There were 1284 VCD episodes (575 and 709 in the CYD-TDV and placebo groups, respectively) and 17673 other febrile episodes (11668 and 6005, respectively). Compared with VCD, the sensitivity and specificity of probable dengue definition were 93.1% and 77.2%, respectively. Overall positive and negative predictive values were 22.9% and 99.5%, respectively, reflecting the much lower probability of correctly confirming probable dengue in a population including a vaccinated cohort. Vaccination-induced bias toward false-positive diagnosis was more pronounced among individuals seronegative at baseline. Caution will be required when interpreting IgM and IgG data obtained during routine surveillance in those vaccinated with CYD-TDV. There is an urgent need for new practical, dengue-specific diagnostic algorithms now that CYD-TDV is approved in a number of dengue-endemic countries. NCT01373281 and NCT01374516.

  11. Dengue death with evidence of hemophagocytic syndrome and dengue virus infection in the bone marrow.

    Science.gov (United States)

    Ab-Rahman, Hasliana Azrah; Wong, Pooi-Fong; Rahim, Hafiz; Abd-Jamil, Juraina; Tan, Kim-Kee; Sulaiman, Syuhaida; Lum, Chai-See; Syed-Omar, Syarifah-Faridah; AbuBakar, Sazaly

    2015-01-01

    HPS is a potentially life-threatening histiocytic disorder that has been described in various viral infections including dengue. Its involvement in severe and fatal dengue is probably more common but is presently under recognized. A 38-year-old female was admitted after 5 days of fever. She was deeply jaundiced, leukopenic and thrombocytopenic. Marked elevation of transaminases, hyperbilirubinemia and hypoalbuminemia were observed. She had deranged INR values and prolonged aPTT accompanied with hypofibrinogenemia. She also had splenomegaly. She was positive for dengue IgM. Five days later she became polyuric and CT brain image showed gross generalized cerebral edema. Her conditions deteriorated by day 9, became confused with GCS of 9/15. Her BMAT showed minimal histiocytes. Her serum ferritin level peaked at 13,670.00 µg/mL and her sCD163 and sCD25 values were markedly elevated at 4750.00 ng/mL and 4191.00 pg/mL, respectively. She succumbed to the disease on day 10 and examination of her tissues showed the presence of dengue virus genome in the bone marrow. It is described here, a case of fatal dengue with clinical features of HPS. Though BMAT results did not show the presence of macrophage hemophagocytosis, other laboratory features were consistent with HPS especially marked elevation of ferritin, sCD163 and sCD25. Detection of dengue virus in the patient's bone marrow, fifteen days after the onset of fever was also consistent with the suggestion that the HPS is associated with dengue virus infection. The findings highlight HPS as a possible complication leading to severe dengue and revealed persistent dengue virus infection of the bone marrow. Detection of HPS markers; ferritin, sCD163 and sCD25, therefore, should be considered for early recognition of HPS-associated dengue.

  12. Enhancing the Immunogenicity of a Tetravalent Dengue DNA Vaccine

    Science.gov (United States)

    2016-08-01

    season’s influenza vaccine. There is no overlap with the proposed project. Title: Serological survey for Zika virus and other vector-borne pathogen...studying human immunology and pathogenesis of dengue virus infection Time Commitments: 5% 0.6 calendar months Supporting Agency: Military Infectious...attenuated dengue virus vaccine (LAV), and (3) inactivated dengue virus vaccine. Dengue fever ranks among the top infectious diseases that afflict

  13. A case of acute liver failure in dengue hemorrhagic fever

    Directory of Open Access Journals (Sweden)

    Rama Biswas

    2013-07-01

    Full Text Available Dengue is an arboviral disease endemic in many parts of the world. The clinical presentation of dengue viral infection ranges from asymptomatic illness to fatal dengue shock syndrome. Although, it is known to cause hepatic involvement, it occasionally results in acute hepatic failure. We report a case of dengue hemorrhagic fever presenting with acute liver failure. The case recovered completely after treatment. Ibrahim Med. Coll. J. 2013; 7(2: 41-42

  14. Dengue in the Americas and Southeast Asia: do they differ?

    Science.gov (United States)

    Halstead, Scott B

    2006-12-01

    The populations of Southeast Asia (SE Asia) and tropical America are similar, and all four dengue viruses of Asian origin are endemic in both regions. Yet, during comparable 5-year periods, SE Asia experienced 1.16 million cases of dengue hemorrhagic fever (DHF), principally in children, whereas in the Americas there were 2.8 million dengue fever (DF) cases, principally in adults, and only 65,000 DHF cases. This review aims to explain these regional differences. In SE Asia, World War II amplified Aedes aegypti populations and the spread of dengue viruses. In the Americas, efforts to eradicate A. aegypti in the 1940s and 1950s contained dengue epidemics mainly to the Caribbean Basin. Cuba escaped infections with the American genotype dengue-2 and an Asian dengue-3 endemic in the 1960s and 1970s. Successive infections with dengue-1 and an Asian genotype dengue-2 resulted in the 1981 DHF epidemic. When this dengue-2 virus was introduced in other Caribbean countries, it encountered populations highly immune to the American genotype dengue-2. During the 1980s and 1990s, rapidly expanding populations of A. aegypti in Brazil permitted successive epidemics of dengue-1, -2, and -3. These exposures, however, resulted mainly in DF, with surprisingly few cases of DHF. The absence of high rates of severe dengue disease in Brazil, as elsewhere in the Americas, may be partly explained by the widespread prevalence of human dengue resistance genes. Understanding the nature and distribution of these genes holds promise for containing severe dengue. Future research on dengue infections should emphasize population-based designs.

  15. Dengue in the Americas and Southeast Asia: do they differ?

    Directory of Open Access Journals (Sweden)

    Scott B. Halstead

    2006-12-01

    Full Text Available The populations of Southeast Asia (SE Asia and tropical America are similar, and all four dengue viruses of Asian origin are endemic in both regions. Yet, during comparable 5-year periods, SE Asia experienced 1.16 million cases of dengue hemorrhagic fever (DHF, principally in children, whereas in the Americas there were 2.8 million dengue fever (DF cases, principally in adults, and only 65 000 DHF cases. This review aims to explain these regional differences. In SE Asia, World War II amplified Aedes aegypti populations and the spread of dengue viruses. In the Americas, efforts to eradicate A. aegypti in the 1940s and 1950s contained dengue epidemics mainly to the Caribbean Basin. Cuba escaped infections with the American genotype dengue-2 and an Asian dengue-3 endemic in the 1960s and 1970s. Successive infections with dengue-1 and an Asian genotype dengue-2 resulted in the 1981 DHF epidemic. When this dengue-2 virus was introduced in other Caribbean countries, it encountered populations highly immune to the American genotype dengue-2. During the 1980s and 1990s, rapidly expanding populations of A. aegypti in Brazil permitted successive epidemics of dengue-1, -2, and -3. These exposures, however, resulted mainly in DF, with surprisingly few cases of DHF. The absence of high rates of severe dengue disease in Brazil, as elsewhere in the Americas, may be partly explained by the widespread prevalence of human dengue resistance genes. Understanding the nature and distribution of these genes holds promise for containing severe dengue. Future research on dengue infections should emphasize population-based designs.

  16. All Serotypes of Dengue Viruses Circulating in Kuala Lumpur, Malaysia

    OpenAIRE

    M.H. Chew; M.M. Rahman; J. Jelip; M.R. Hassan; I. Isahak

    2012-01-01

    Dengue is a severe disease caused by dengue virus (DENV), transmitted to human being by infected Aedes mosquitoes. It is a major public health concern in Southeast Asia due to its fatality in the form of hemorrhagic fever (DHF) and dengue shock syndrome (DSS). The objective of the study was to isolate and identify dengue virus serotypes prevalent in endemic areas of Kuala Lumpur and Selangor in Malaysia by virus culture, indirect immunoflurecent assay and molecular techniques. A total number ...

  17. Yellow fever in Brazil: thoughts and hypotheses on the emergence in previously free areas Fiebre amarilla en Brasil: reflexiones e hipótesis sobre la emergencia en áreas previamente libres Febre amarela no Brasil: reflexões e hipóteses sobre a emergência em áreas previamente livres

    Directory of Open Access Journals (Sweden)

    Pedro Fernando da Costa Vasconcelos

    2010-12-01

    Full Text Available This article describes and discusses factors associated to the reemergence of yellow fever and its transmission dynamics in the states of São Paulo (Southeastern Brazil and Rio Grande do Sul (Southern during 2008 and 2009. The following factors have played a pivotal role for the reemergence of yellow fever in these areas: large susceptible human population; high prevalence of vectors and primary hosts (non-human primates; favorable climate conditions, especially increased rainfall; emergence of a new genetic lineage; and circulation of people and/or monkeys infected by virus. There is a need for an effective surveillance program to prevent the reemergence of yellow fever in other Brazilian states.Son descritos y discutidos factores asociados con la emergencia y dinámica de la transmisión de la fiebre amarilla en los estados de Sao Paulo (Sureste de Brasil y Rio Grande do Sul (Sur de Brasil en los años 2008 y 2009. La interacción de los siguientes factores fue fundamental para la emergencia de fiebre amarilla en esos estados: la gran población humana susceptible; la elevada prevalencia de vectores y hospedadores (primates no humanos; condiciones climáticas favorables, principalmente el exceso de lluvias en el verano; la emergencia de un nuevo linaje viral; y la circulación de personas o monos infectados en fase virémica. Sólo un programa eficiente de vigilancia puede prevenir ocurrencias similares en esos estados brasileros.São descritos e discutidos fatores associados a emergência e dinâmica da transmissão da febre amarela nos estados de São Paulo e Rio Grande do Sul nos anos de 2008 e 2009. A interação dos seguintes fatores foi fundamental para a emergência de febre amarela nesses estados: a grande população humana suscetível; a elevada prevalência de vetores e hospedeiros (primatas não humanos; condições climáticas favoráveis, sobretudo o excesso de chuvas no verão; a emergência de uma nova linhagem viral; e a

  18. Virus isolation for diagnosing dengue virus infections in returning travelers

    NARCIS (Netherlands)

    Teichmann, D.; Göbels, K.; Niedrig, M.; Sim-Brandenburg, J.-W.; Làge-Stehr, J.; Grobusch, M. P.

    2003-01-01

    Dengue fever is recognized as one of the most frequent imported acute febrile illnesses affecting European tourists returning from the tropics. In order to assess the value of virus isolation for the diagnosis of dengue fever, 70 cases of dengue fever confirmed in German travelers during the period

  19. Current perspectives on the spread of dengue in India

    Directory of Open Access Journals (Sweden)

    Gupta E

    2014-12-01

    Full Text Available Ekta Gupta, Neha Ballani Department of Clinical Virology, Institute of Liver and Biliary Sciences, New Delhi, IndiaAbstract: Dengue fever (DF and dengue hemorrhagic fever (DHF are important arthropod-borne viral diseases. Each year, there are ~50 million dengue infections and ~500,000 individuals are hospitalized with DHF, mainly in Southeast Asia. Dengue in India has dramatically expanded over the last few decades, with rapidly changing epidemiology. The first major DHF outbreak in the entire nation occurred in 1996 by dengue virus serotype 2, and after a gap of almost a decade, the country faced yet another DF outbreak in the year 2003 by dengue virus serotype 3. A dramatic increase in the number and frequency of outbreaks followed, and, at present, in most of the states of India, dengue is almost endemic. At present, all the four serotypes are seen in circulation, but the predominant serotype keeps changing. Despite this trend, surveillance, reporting, and diagnosis of dengue remain largely passive in India. More active community-based epidemiological studies with intensive vector control and initiatives for dengue vaccine development should be geared up to control the spread of dengue in India. We review here the factors that may have contributed to the changing epidemiology of dengue in India.Keywords: dengue, epidemiology, India, pathogenesis, vaccine

  20. Seroprevalence of Anti-Dengue Virus 2 Serocomplex antibodies in ...

    African Journals Online (AJOL)

    Introduction: There has been a recent increase in the spread of dengue to rural areas. Rural parts of western kenya are naturally prone to mosquito-borne diseases, however, limited research has been documented on infections with dengue. This study therefore investigated the presence of antibodies against dengue virus ...

  1. Biomarkers in differentiating clinical dengue cases: A prospective cohort study

    Directory of Open Access Journals (Sweden)

    Gary Kim Kuan Low

    2015-12-01

    Full Text Available Objective: To evaluate five biomarkers (neopterin, vascular endothelial growth factor-A, thrombomodulin, soluble vascular cell adhesion molecule 1 and pentraxin 3 in differentiating clinical dengue cases. Methods: A prospective cohort study was conducted whereby the blood samples were obtained at day of presentation and the final diagnosis were obtained at the end of patients’ follow-up. All patients included in the study were 15 years old or older, not pregnant, not infected by dengue previously and did not have cancer, autoimmune or haematological disorder. Median test was performed to compare the biomarker levels. A subgroup Mann-Whitney U test was analysed between severe dengue and non-severe dengue cases. Monte Carlo method was used to estimate the 2-tailed probability (P value for independent variables with unequal number of patients. Results: All biomarkers except thrombomodulin has P value < 0.001 in differentiating among the healthy subjects, non-dengue fever, dengue without warning signs and dengue with warning signs/severe dengue. Subgroup analysis for all the biomarkers between severe dengue and non-severe dengue cases was not statistically significant except vascular endothelial growth factor-A (P < 0.05. Conclusions: Certain biomarkers were able to differentiate the clinical dengue cases. This could be potentially useful in classifying and determining the severity of dengue infected patients in the hospital.

  2. Dengue fatality prediction using data mining | Rahim | Journal of ...

    African Journals Online (AJOL)

    The aim of this research is to study the current implementation of dengue outbreak control in Malaysia and predict dengue fever cases using data mining techniques. Real data on dengue fever and weather are collected from the Ministry of Health in its Perak Tengah district office and Perak Meteorological office respectively ...

  3. Dengue-associated telogen effluvium: A report of 14 patients

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    Chia-Bao Chu

    2017-09-01

    Conclusions: Physicians should be aware of dengue-associated TE especially in dengue endemic areas or after a dengue outbreak. Thorough medical history, examination and laboratory tests should be obtained to yield correct diagnosis or to identify coexistence of two hair diseases.

  4. Fulminant hepatic failure in an infant with severe dengue infection.

    Science.gov (United States)

    Soundravally, R; Narayanan, P; Bhat, B Vishnu; Soundraragavan, Jayanthi; Setia, Sajita

    2010-04-01

    Fulminant hepatic failure due to dengue infection is rare, although mild liver dysfunction is common. Here we report a fatal case of fulminant hepatitis in an infant infected with dengue 3 serotype. Attention must be given to the use of hepatotoxic drugs in some cases of dengue especially in infants.

  5. Spontaneous muscle hematomas in a patient with Dengue hemorrhagic fever

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    Jency Maria Koshy

    2014-01-01

    Full Text Available Dengue hemorrhagic fever (DHF and Dengue shock syndrome manifest in various forms, ranging from petechial skin hemorrhage to life threatening cerebral, pulmonary, gastrointestinal and genitourinary hemorrhages. However it is very rare to have muscle hematomas in DHF. We report a rare case of spontaneous Iliopsoas hematoma complicating Dengue hemorrhagic fever.

  6. Dengue Virus 1 Outbreak in Buenos Aires, Argentina, 2016.

    Science.gov (United States)

    Tittarelli, Estefanía; Lusso, Silvina B; Goya, Stephanie; Rojo, Gabriel L; Natale, Mónica I; Viegas, Mariana; Mistchenko, Alicia S; Valinotto, Laura E

    2017-10-01

    The largest outbreak of dengue in Buenos Aires, Argentina, occurred during 2016. Phylogenetic, phylodynamic, and phylogeographic analyses of 82 samples from dengue patients revealed co-circulation of 2 genotype V dengue virus lineages, suggesting that this virus has become endemic to the Buenos Aires metropolitan area.

  7. Immature dengue virus : functional properties and potential contribution to disease

    NARCIS (Netherlands)

    Da Silva-Voorham, Júlia Maria

    2013-01-01

    Beter inzicht in mechanismen achter infectieziekte dengue Dengue (‘knokkelkoorts’) is een veelvoorkomende, tropische infectieziekte die wordt overgebracht door muggen. Naar schatting raken jaarlijks zo’n vijftig tot honderd miljoen mensen besmet. Meestal gaat dengue vanzelf over, maar in zo’n

  8. Relato de caso: transmissão vertical de dengue Case report: vertical dengue infection

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    Samara L. C. Maroun

    2008-12-01

    Full Text Available OBJETIVOS: Relatar um caso de transmissão vertical de dengue ocorrido durante epidemia de 2008 pelo vírus tipo II no Rio de Janeiro e revisar a literatura sobre transmissão vertical de dengue. DESCRIÇÃO: Relatamos um caso de transmissão vertical de dengue. Recém-nascido a termo do sexo feminino, peso de nascimento de 3.940 g, foi admitida na unidade de terapia intensiva neonatal com rash cutâneo, hipoatividade e febre no quinto dia de vida. O hemograma evidenciava plaquetopenia importante (38.000 plaquetas. A mãe apresentou quadro clínico compatível com dengue 3 dias antes do parto. Foram colhidos então IgM para dengue da mãe e do recém-nascido, realizados pelo método de ELISA, sendo positivos em ambos. Dengue tipo 2 foi detectado no recém-nascido através de reação em cadeia da polimerase. COMENTÁRIOS: Este relato enfatiza a importância do pediatra estar alerta para a possibilidade de transmissão vertical de dengue iniciando precocemente o tratamento.OBJECTIVES: To report a case of vertical dengue infection in a newborn from Rio de Janeiro, Brazil, and to review the literature concerning this problem. DESCRIPTION: We report a case of vertical dengue infection. Female neonate, birth weight 3,940 g, term, was admitted to a neonatal intensive care unit on the fifth day of life with fever and erythematous rash. Her mother had had dengue fever 3 days before delivery. Her platelet count was 38,000, dropping to 15,000. She did not have any hemorrhagic episodes, including cerebral hemorrhages. Anti-dengue antibodies (IgM were positive in the mother and infant. Dengue type 2 was detected in the infant using polymerase chain reaction. COMMENTS: This report emphasizes that pediatricians should be aware of the possibility of vertical dengue infection so that early management can be instituted.

  9. Validation of dengue infection severity score

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    Pongpan S

    2014-03-01

    Full Text Available Surangrat Pongpan,1,2 Jayanton Patumanond,3 Apichart Wisitwong,4 Chamaiporn Tawichasri,5 Sirianong Namwongprom1,6 1Clinical Epidemiology Program, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; 2Department of Occupational Medicine, Phrae Hospital, Phrae, Thailand; 3Clinical Epidemiology Program, Faculty of Medicine, Thammasat University, Bangkok, Thailand; 4Department of Social Medicine, Sawanpracharak Hospital, Nakorn Sawan, Thailand; 5Clinical Epidemiology Society at Chiang Mai, Chiang Mai, Thailand; 6Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand Objective: To validate a simple scoring system to classify dengue viral infection severity to patients in different settings. Methods: The developed scoring system derived from 777 patients from three tertiary-care hospitals was applied to 400 patients in the validation data obtained from another three tertiary-care hospitals. Percentage of correct classification, underestimation, and overestimation was compared. The score discriminative performance in the two datasets was compared by analysis of areas under the receiver operating characteristic curves. Results: Patients in the validation data were different from those in the development data in some aspects. In the validation data, classifying patients into three severity levels (dengue fever, dengue hemorrhagic fever, and dengue shock syndrome yielded 50.8% correct prediction (versus 60.7% in the development data, with clinically acceptable underestimation (18.6% versus 25.7% and overestimation (30.8% versus 13.5%. Despite the difference in predictive performances between the validation and the development data, the overall prediction of the scoring system is considered high. Conclusion: The developed severity score may be applied to classify patients with dengue viral infection into three severity levels with clinically acceptable under- or overestimation. Its impact when used in routine

  10. Clinico-laboratory spectrum of dengue viral infection and risk factors associated with dengue hemorrhagic fever: a retrospective study

    OpenAIRE

    Mallhi, Tauqeer Hussain; Khan, Amer Hayat; Adnan, Azreen Syazril; Sarriff, Azmi; Khan, Yusra Habib; Jummaat, Fauziah

    2015-01-01

    Background The incidence of dengue is rising steadily in Malaysia since the first major outbreak in 1973. Despite aggressive measures taken by the relevant authorities, Malaysia is still facing worsening dengue crisis over the past few years. There is an urgent need to evaluate dengue cases for better understanding of clinic-laboratory spectrum in order to combat this disease. Methods A retrospective analysis of dengue patients admitted to a tertiary care teaching hospital during the period o...

  11. Tipificación molecular del virus dengue 3 durante el brote epidémico de dengue clásico en Lima, Perú, 2005

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    Enrique Mamani Z

    2005-07-01

    Full Text Available Objetivos: Identificar mediante trascripción reversa-reacción en cadena de la polimerasa (RT-PCR y sitios específicos de restricción - reacción en cadena de la polimerasa (RSS-PCR al agente causal del brote epidémico presentado en el distrito de Comas, Lima en abril del año 2005. Materiales y métodos: veinte muestras de suero colectadas durante el brote de dengue fueron procesados por RT-PCR para determinar el serotipo, esta técnica se realizó en un solo paso. Luego se aplicó la técnica RSS-PCR para la identificación del genotipo circulante y se corroboraron los resultados posteriormente con aislamiento viral y secuenciamiento. Resultados: El análisis del RTPCR del ARN extraído de las muestras presentó un producto amplificado de 290pb que corresponden al dengue serotipo 3 (DEN 3. El análisis de los productos de RSS-PCR del ARN extraído a partir de aislamientos de DEN 3 correspondió al patrón C, incluido en el genotipo III. Los aislamientos de los virus dengue 3 en líneas celulares C6/36, tipificadas por IFI y el secuenciamiento genético confirmaron los resultados obtenidos por las pruebas previamente descritas. Conclusión: Durante el brote epidémico de dengue clásico en Lima, circuló el genotipo III del virus DEN 3.

  12. Dengue in Costa Rica: the gap in local scientific research Dengue en Costa Rica: la brecha en la investigación científica local

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    Adriana Troyo

    2006-11-01

    Full Text Available El dengue es una enfermedad de gran importancia a escala mundial. Los esfuerzos para su control en la mayoría de las regiones del mundo no han logrado detener el aumento en su incidencia, y se fomenta la investigación científica para contribuir a desarrollar nuevos enfoques de control basados en la evidencia científica o a mejorar los existentes. Enfermedad recientemente reemergente en Costa Rica, el dengue se ha convertido en un grave problema de salud en ese país. A pesar de esta crítica situación, se dispone de pocas publicaciones científicas sobre dengue en Costa Rica. En una búsqueda realizada en la base de datos PubMed se encontraron solo 11 artículos, mientras que en varias bases de datos bibliográficas centradas en Costa Rica y otros países de América Latina se hallaron 19 artículos más. Además, se encontraron 10 tesis relacionadas con el dengue realizadas en universidades costarricenses. Por lo tanto, son pocos los artículos científicos originales publicados sobre este tema en revistas científicas arbitradas, especialmente en aspectos vinculados con la epidemiología, la salud pública y la idoneidad y eficacia de las intervenciones en marcha. Esta brecha en las investigaciones puede deberse a diversos factores, como el contexto histórico y político, insuficientes recursos financieros y humanos, deficiencias en la colaboración entre las instituciones y dificultades para disponer de los datos. Costa Rica puede aprender de la experiencia de otros países de la Región de las Américas (como Cuba y Trinidad y Tobago, donde se ha investigado mucho más sobre dengue. Las investigaciones de esos dos países han aportado evidencias cruciales para el desarrollo de estrategias locales y generales dirigidas al control y la prevención del dengue. En dependencia del contexto local, algunos métodos de control pueden ser más eficaces que otros, por lo que las acciones basadas en la evidencia deben adaptarse para las

  13. Niño con cardiopatía congénita controlada y muerte inesperada

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    Javier Horacio López Terrazas

    2016-10-01

    Full Text Available Niño de ocho meses de edad que llegó al Servicio de Urgencias del Instituto Nacional de Pediatría con cuadro de un día evolución con fiebre, odinofagia, vómitos y tres evacuaciones diarreicas abundantes. Falleció al día siguiente de su ingreso. Había ido al hospital donde se llevaba a cabo su manejo y en el que le administraron paracetamol, pero al día siguiente presentaba deshidratación, quejido respiratorio y saturaba 50% al aire ambiente, por lo que los padres administraron oxígeno por puntas nasales y acudieron a este Instituto.

  14. Serodiagnosis of dengue infection using rapid immunochromatography test in patients with probable dengue infection.

    Science.gov (United States)

    Kidwai, Aneela Altaf; Jamal, Qaiser; Saher; Mehrunnisa; Farooqi, Faiz-ur-rehman; Saleem-Ullah

    2010-11-01

    To determine the frequency of seropositive dengue infection using rapid immunochromatographic assay in patients with probable dengue infection as per WHO criteria. A cross-sectional observational study was conducted at Abbasi Shaheed Hospital, Karachi from July 2008 to January 2009. Patients presenting with acute febrile illness, rashes, bleeding tendencies, leucopenia and or thrombocytopenia were evaluated according to WHO criteria for probable dengue infection. Acute phase sera were collected after 5 days of the onset of fever as per WHO criteria. Serology was performed using rapid immunochromatographic (ICT) assay with differential detection of IgM and IgG. A primary dengue infection was defined by a positive IgM band and a negative IgG band whereas secondary infection was defined by a positive IgG band with or without positive IgM band. Among 599 patients who met the WHO criteria for dengue infection, 251(41.9%) were found to be ICT reactive among whom 42 (16.73%) had primary infection. Secondary infection was reported in 209 (83.26%). Acute phase sera of 348 (58.09%) were ICT non reactive. Four patients died because of dengue shock syndrome among which three had secondary infection. Early identification of secondary infection in acute phase sera using rapid ICT is valuable in terms of disease progression and mortality. However in highly suspected cases of dengue infection clinical management should not rely on negative serological results.

  15. Serodiagnosis of dengue infection using rapid immuno chromatography test in patients with probable dengue infection

    International Nuclear Information System (INIS)

    Kidwai, A.A.; Jamal, Q.; Mehrunnisa, S.; Farooqi, F.R.

    2010-01-01

    Objective: To determine the frequency of seropositive dengue infection using rapid immuno chromatographic assay in patients with probable dengue infection as per WHO criteria. Method: A cross-sectional observational study was conducted at Abbasi Shaheed Hospital, Karachi from July 2008 to January 2009. Patients presenting with acute febrile illness, rashes, bleeding tendencies, leucopenia and or thrombocytopenia were evaluated according to WHO criteria for probable dengue infection. Acute phase sera were collected after 5 days of the onset of fever as per WHO criteria. Serology was performed using rapid immuno chromatographic (ICT) assay with differential detection of IgM and IgG. A primary dengue infection was defined by a positive IgM band and a negative IgG band whereas secondary infection was defined by a positive IgG band with or without positive IgM band. Result: Among 599 patients who met the WHO criteria for dengue infection, 251(41.9%) were found to be ICT reactive among whom 42 (16.73%) had primary infection. Secondary infection was reported in 209 (83.26%). Acute phase sera of 348 (58.09%) were ICT non reactive. Four patients died because of dengue shock syndrome among which three had secondary infection. Conclusion: Early identification of secondary infection in acute phase sera using rapid ICT is valuable in terms of disease progression and mortality. However in highly suspected cases of dengue infection clinical management should not rely on negative serological results. (author)

  16. Dengue Virus Genome Uncoating Requires Ubiquitination.

    Science.gov (United States)

    Byk, Laura A; Iglesias, Néstor G; De Maio, Federico A; Gebhard, Leopoldo G; Rossi, Mario; Gamarnik, Andrea V

    2016-06-28

    The process of genome release or uncoating after viral entry is one of the least-studied steps in the flavivirus life cycle. Flaviviruses are mainly arthropod-borne viruses, including emerging and reemerging pathogens such as dengue, Zika, and West Nile viruses. Currently, dengue virus is one of the most significant human viral pathogens transmitted by mosquitoes and is responsible for about 390 million infections every year around the world. Here, we examined for the first time molecular aspects of dengue virus genome uncoating. We followed the fate of the capsid protein and RNA genome early during infection and found that capsid is degraded after viral internalization by the host ubiquitin-proteasome system. However, proteasome activity and capsid degradation were not necessary to free the genome for initial viral translation. Unexpectedly, genome uncoating was blocked by inhibiting ubiquitination. Using different assays to bypass entry and evaluate the first rounds of viral translation, a narrow window of time during infection that requires ubiquitination but not proteasome activity was identified. In this regard, ubiquitin E1-activating enzyme inhibition was sufficient to stabilize the incoming viral genome in the cytoplasm of infected cells, causing its retention in either endosomes or nucleocapsids. Our data support a model in which dengue virus genome uncoating requires a nondegradative ubiquitination step, providing new insights into this crucial but understudied viral process. Dengue is the most significant arthropod-borne viral infection in humans. Although the number of cases increases every year, there are no approved therapeutics available for the treatment of dengue infection, and many basic aspects of the viral biology remain elusive. After entry, the viral membrane must fuse with the endosomal membrane to deliver the viral genome into the cytoplasm for translation and replication. A great deal of information has been obtained in the last decade

  17. Valvuloplastia mitral percutánea de emergencia en un paciente con edema pulmonar refractario

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    Alejandra I. de Zubiría

    2018-01-01

    Full Text Available La estenosis mitral usualmente es causada por fiebre reumática. A pesar de ser una patología poco frecuente en los países desarrollados, es prevalente en los países en vía de desarrollo, donde aproximadamente dos tercios de la población mundial vive, haciendo de esta condición, una enfermedad valvular común. Es importante considerar la estenosis mitral en el diagnóstico diferencial de los pacientes con edema agudo de pulmón cardiogénico refractario y la valvuloplastia mitral percutánea de emergencia como el tratamiento definitivo. Se presenta el caso de un paciente femenino de 21 años, con edema agudo de pulmón cardiogénico refractario, secundario a estenosis mitral muy severa de origen reumático, tratado con valvuloplastia percutánea con balón de urgencia. Se realiza una revisión sobre la estenosis mitral y se examina el tratamiento con especial énfasis en los casos publicados en la literatura de valvuloplastia mitral percutánea de emergencia.

  18. Dengue vaccines: Are they safe for travelers?

    Science.gov (United States)

    Halstead, Scott B; Aguiar, Maira

    2016-01-01

    The four dengue viruses (DENV) circulate among nearly one-half of the world's population in tropical and semitropical countries imposing a huge morbidity burden on travelers. Sanofipasteur has developed a tetravalent live-attenuated vaccine, Dengvaxia, recently approved by the World Health Organization and licensed in four dengue-endemic countries. An additional two dengue vaccines, developed by the National Institute of Allergy and Infectious Diseases (NIAID), USA and Takeda, are entering phase III testing. Dengvaxia is composed of four yellow fever 17D-DENV chimeras, the NIAID vaccine contains three mutagenized DENV and one DENV2/4 chimera while the Takeda vaccine contains an attenuated DENV 2 and three DENV 2-DENV chimeras. Which of these vaccines might be useful in protecting travelers against dengue infections and disease? Dengvaxia requires three doses administered over the course of one year but in addition has safety signals suggesting that susceptible individuals should not be vaccinated. The NIAID vaccine is promising as a travel vaccine as a single dose fully protected susceptible adults against live dengue 2 virus challenge. The protective efficacy and safety of the Takeda vaccine remain to be demonstrated. Copyright © 2016 Elsevier Ltd. All rights reserved.

  19. Activity of andrographolide against dengue virus.

    Science.gov (United States)

    Panraksa, Patcharee; Ramphan, Suwipa; Khongwichit, Sarawut; Smith, Duncan R

    2017-03-01

    Dengue is the most prevalent arthropod-transmitted viral illness of humans, with an estimated 100 million symptomatic infections occurring each year and more than 2.5 billion people living at risk of infection. There are no approved antiviral agents against dengue virus, and there is only limited introduction of a dengue vaccine in some countries. Andrographolide is derived from Andrographis paniculata, a medicinal plant traditionally used to treat a number of conditions including infections. The antiviral activity of andrographolide against dengue virus (DENV) serotype 2 was evaluated in two cell lines (HepG2 and HeLa) while the activity against DENV 4 was evaluated in one cell line (HepG2). Results showed that andrographolide had significant anti-DENV activity in both cell lines, reducing both the levels of cellular infection and virus output, with 50% effective concentrations (EC 50 ) for DENV 2 of 21.304 μM and 22.739 μM for HepG2 and HeLa respectively. Time of addition studies showed that the activity of andrographolide was confined to a post-infection stage. These results suggest that andrographolide has the potential for further development as an anti-viral agent for dengue virus infection. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. First Iranian imported case of dengue

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    Masoud Mardani

    2013-01-01

    Full Text Available Dengue fever, a mosquito-borne flavivirus infection, is endemic in Southeast Asia. Currently, incidences have been increasing among adults. There have been no published reports of dengue fever from Iran. Widespread connection between different countries may predispose them for acquisition of infection. The patient was a 58-year-old Iranian woman with acute unexplained high-grade fever for 4 days, associated with skin rash, after returning from Southeast Asia. CBC showed WBC = 1600/mm 3 and platelet count 99,000/mm 3 . The patient also had hematuria. ELISA immunoglobulin M (IgM antibodies to dengue and serum RT-PCR for dengue virus was positive. The patient managed with conservative treatment and due to good general condition and improvement specific antiviral treatment was not started. She became afebrile at the 3 rd day of hospitalization and discharged with good general condition on fourth day. She was afebrile after two weeks follow-up. Dengue fever has been increasing among adults. It should be suspected, when a patient presents with acute febrile illness and skin rashes returning from endemic region. Conservative treatment may be conducted in uncomplicated cases .

  1. Dengue: muscle biopsy findings in 15 patients

    Directory of Open Access Journals (Sweden)

    S.M.F. Malheiros

    1993-06-01

    Full Text Available Dengue is known to produce a syndrome involving muscles, tendons and joints. The hallmark of this syndrome is severe myalgia but includes fever, cutaneous rash, and headache. The neuromuscular aspects of this infection are outlined only in isolated reports, and the muscle histopathological features during myalgia have not been described. In order to ascertain the actual neuromuscular involvement in dengue and better comprehend the histological nature of myalgia, we performed a clinical and neurological evaluation, a serum CPK level and a muscle biopsy (with histochemistry in 15 patients (4 males, median age 23 years (range 14-47 with classic dengue fever, serologically confirmed, during the bra-zilian dengue epidemics from September 1986 to March 1987. All patients had a history of fever, headache and severe myalgia. Upon examination 4 had a cutaneous rash, 3 had fever, and 3 a small hepatomegaly. The neurological examination was unremarkable in all and included a manual muscle test. CPK was mildly elevated in only 3 patients. Muscle biopsy revealed a light to moderate perivascular mononuclear infiltrate in 12 patients and lipid accumulation in 11. Mild mitochondrial proliferation was seen in 3, few central nuclei in 3, rare foci of myonecrosis in 3, and 2 patients had type grouping. Dengue in our patients, produced myalgia but no detectable muscle weakness or other neuromuscular involvement. The main histopathological correlation with myalgia seems to be a perivascular mononuclear infiltrate and lipid accumulation.

  2. Spatial patterns of dengue cases in Brazil.

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    Fernando Jose Antonio

    Full Text Available Dengue infection plays a central role in our society, since it is the most prevalent vector-borne viral disease affecting humans. We statistically investigated patterns concerning the spatial spreading of dengue epidemics in Brazil, as well as their temporal evolution in all Brazilian municipalities for a period of 12 years. We showed that the distributions of cases in municipalities follow power laws persistent in time and that the infection scales linearly with the population of the municipalities. We also found that the average number of dengue cases does not have a clear dependence on the longitudinal position of municipalities. On the other hand, we found that the average distribution of cases varies with the latitudinal position of municipalities, displaying an almost constant growth from high latitudes until reaching the Tropic of Capricorn leveling to a plateau closer to the Equator. We also characterized the spatial correlation of the number of dengue cases between pairs of municipalities, where our results showed that the spatial correlation function decays with the increase of distance between municipalities, following a power-law with an exponential cut-off. This regime leads to a typical dengue traveling distance. Finally, we considered modeling this last behaviour within the framework of a Edwards-Wilkinson equation with a fractional derivative on space.

  3. Current Status of Dengue Therapeutics Research and Development.

    Science.gov (United States)

    Low, Jenny G H; Ooi, Eng Eong; Vasudevan, Subhash G

    2017-03-01

    Dengue is a significant global health problem. Even though a vaccine against dengue is now available, which is a notable achievement, its long-term protective efficacy against each of the 4 dengue virus serotypes remains to be definitively determined. Consequently, drugs directed at the viral targets or critical host mechanisms that can be used safely as prophylaxis or treatment to effectively ameliorate disease or reduce disease severity and fatalities are still needed to reduce the burden of dengue. This review will provide a brief account of the status of therapeutics research and development for dengue. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America.

  4. Dengue fever with rectus sheath hematoma: A case report

    Directory of Open Access Journals (Sweden)

    Anurag Sharma

    2014-01-01

    Full Text Available Dengue fever, also known as breakbone fever, is an infectious tropical disease caused by the Dengue virus. It is associated with a number of complications, which are well documented. However, Dengue fever associated with rectus sheath hematoma (RSH is a very rare complication. Only one case report has been published prior supporting the association of Dengue fever with RSH. We report a case of Dengue fever who presented with RSH and was successfully treated conservatively. RSH is also an uncommon cause of acute abdominal pain. It is accumulation of blood in the sheath of the rectus abdominis, secondary to rupture of an epigastric vessel or muscle tear.

  5. Roles for Endothelial Cells in Dengue Virus Infection

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    Nadine A. Dalrymple

    2012-01-01

    Full Text Available Dengue viruses cause two severe diseases that alter vascular fluid barrier functions, dengue hemorrhagic fever (DHF and dengue shock syndrome (DSS. The endothelium is the primary fluid barrier of the vasculature and ultimately the effects of dengue virus infection that cause capillary leakage impact endothelial cell (EC barrier functions. The ability of dengue virus to infect the endothelium provides a direct means for dengue to alter capillary permeability, permit virus replication, and induce responses that recruit immune cells to the endothelium. Recent studies focused on dengue virus infection of primary ECs have demonstrated that ECs are efficiently infected, rapidly produce viral progeny, and elicit immune enhancing cytokine responses that may contribute to pathogenesis. Furthermore, infected ECs have also been implicated in enhancing viremia and immunopathogenesis within murine dengue disease models. Thus dengue-infected ECs have the potential to directly contribute to immune enhancement, capillary permeability, viremia, and immune targeting of the endothelium. These effects implicate responses of the infected endothelium in dengue pathogenesis and rationalize therapeutic targeting of the endothelium and EC responses as a means of reducing the severity of dengue virus disease.

  6. Metformin Use and Severe Dengue in Diabetic Adults.

    Science.gov (United States)

    Htun, Htet Lin; Yeo, Tsin Wen; Tam, Clarence C; Pang, Junxiong; Leo, Yee Sin; Lye, David C

    2018-02-20

    Diabetes mellitus is a risk factor for severe dengue in adults, but few studies have examined the association between metformin use and disease severity in dengue. In addition to its effect on glucose control, metformin has been associated with pleiotropic properties in preclinical studies. Using a cohort of laboratory-confirmed adult (≥21 years) dengue patients with diabetes mellitus admitted to Tan Tock Seng Hospital, we conducted a retrospective cohort study involving 131 (58.7%) metformin users and 92 (41.3%) non-users. Dengue severity was categorized as dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS) in World Health Organization (WHO) 1997 criteria and severe dengue (SD) in WHO 2009 criteria. Multivariable Poisson regression with robust error variance was used to estimate risk ratio (RR). Compared with non-use, metformin use was associated with a decreased risk of developing severe dengue (adjusted risk ratio [aRR] = 0.60, 95% confidence interval [CI]: 0.37-0.98, P = 0.04). Additionally, there was an inverse dose-response relationship (aRR = 0.69, 95% CI: 0.49-0.98, P = 0.04) with dengue severity as classified by WHO 2009 criteria. Use of metformin, however, was not associated with dengue severity based on WHO 1997 criteria; and no dose-response relationship was noted. Our results suggest metformin use could attenuate disease severity in dengue-infected diabetes mellitus individuals.

  7. Diagnosis of Dengue Infection Using Conventional and Biosensor Based Techniques

    Science.gov (United States)

    Parkash, Om; Hanim Shueb, Rafidah

    2015-01-01

    Dengue is an arthropod-borne viral disease caused by four antigenically different serotypes of dengue virus. This disease is considered as a major public health concern around the world. Currently, there is no licensed vaccine or antiviral drug available for the prevention and treatment of dengue disease. Moreover, clinical features of dengue are indistinguishable from other infectious diseases such as malaria, chikungunya, rickettsia and leptospira. Therefore, prompt and accurate laboratory diagnostic test is urgently required for disease confirmation and patient triage. The traditional diagnostic techniques for the dengue virus are viral detection in cell culture, serological testing, and RNA amplification using reverse transcriptase PCR. This paper discusses the conventional laboratory methods used for the diagnosis of dengue during the acute and convalescent phase and highlights the advantages and limitations of these routine laboratory tests. Subsequently, the biosensor based assays developed using various transducers for the detection of dengue are also reviewed. PMID:26492265

  8. [Imported dengue: an emerging arbovirosis in Spain].

    Science.gov (United States)

    Ramos Geldres, T T; García López-Hortelano, M; Baquero-Artigao, F; Montero Vega, D; López Quintana, B; Mellado Peña, M J

    2015-01-01

    Dengue is caused by one of 4 serotypes of dengue virus. Only imported cases have been reported in Spain. The main clinical findings are fever and exanthema, although there may be severe forms, particularly in secondary infections. Five children with a primary, non severe dengue infection are presented. The diagnosis was based on clinical suspicion and epidemiological history, and confirmed by immunochromatography and ELISA tests. The outcome was favourable in all cases. It is important to consider this diagnosis in international travellers that present with fever within the 14 days of returning from an endemic area, in order to get an early diagnosis, adequate treatment and a good prognosis. Copyright © 2014 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.

  9. Dengue fever in pregnancy: a case report

    Directory of Open Access Journals (Sweden)

    Phupong Vorapong

    2001-12-01

    Full Text Available Abstract Background Dengue, a mosquito-borne flavivirus infection, is endemic in Southeast Asia. Currently, the incidence has been increasing among adults. Case presentation A 26-year-old Thai woman, G1P0 31 weeks pregnancy, presented with epigastric pain for 1 day. She also had a high-grade fever for 4 days. The physical examination, complete blood counts as well as serology confirmed dengue fever. The patient was under conservative treatment despite severe thrombocytopenia. She was well at the 3rd day of discharge and 1-week follow-up. The pregnancy continued until term without any complication and she delivered vaginally a healthy female baby. Conclusions More cases of dengue infection in pregnancy can be found due to the increasing incidence during adulthood. It should be suspected when a pregnant woman presents with symptoms and signs like in a non-pregnant. Conservative treatment should be conducted unless there are any complications.

  10. Anti dengue education: a experience report

    Directory of Open Access Journals (Sweden)

    Marise Maleck

    2017-11-01

    Full Text Available Aedes aegypti (L., 1762 is the main vector recognized as a dengue virus transmitter. This vector, once adapted to human habits, finds it easy to reproduce in homes that have open water containers, easily found in city streets and garbage dumps. Educational institutions play a fundamental role in the formation of young people as disseminator citizens in favor of health improvement practices. In order to promote education for the control of the dengue virus mosquito vector, this work was developed through recreational and educational activities in Central-South Rio de Janeiro state public and private schools, cities, cultural centers and public spaces. The results showed positive responses above 80% of the Aedes-dengue-control issue. The project had 2500 participants. The Antidengue Education Project demonstrated that education is an effective tool regarding education, health and the environment.

  11. [Epidemiological dynamics of Dengue on Easter Island].

    Science.gov (United States)

    Canals, Mauricio; González, Christian; Canals, Andrea; Figueroa, Daniela

    2012-08-01

    Dengue is considered an emerging disease with an increasing prevalence especially in South America. In 2002, an epidemic of classic Dengue (DENV-1) occurred unexpectedly on Easter Island, where it had never been detected before. It reappeared in 2006-2007 and 2008, 2009 and 2011. The aim of this study was to estimate the most relevant parameters of the epidemiological dynamics of transmission of Dengue on Easter Island and to model the dynamics since 2002, comparing the predictions with the actual situation observed. Of the total cases, 52.27% were females and 47.73% men. The average age of infection was 31.38 ± 18.37 years, similar in men and women. We estimated the reproductive number R0 = 3.005 with an IC0,95 = [1.92, 4.61]. The inter-epidemic period reached an estimated T = 5.20 to 6.8 years. The case simulation showed recurrent epidemics with decreasing magnitude (damped oscillations), which is a known phenomenon in models of dengue and malaria. There was good qualitative fit to the epidemiological dynamics from 2002 onwards. It accurately predicted the rise in cases between 2006 and 2011. The predicted number of cases during the 2002 epidemic is greater than the confirmed cases and the predicted epidemic was faster than notified cases. Interepidemic period in the simulation was 6.72 years between 2002 and 2008 and 4.68 years between 2008 and 2013. From the theoretical perspective, the first epidemic had affected 94% of the population (approximately 3500 cases), but 639 were reported suggesting underreporting and a lot of sub-clinical cases occurred. Future epidemic of decreasing size are expected, although the main danger are epidemics of hemorrhagic dengue fever resulting from the introduction of different dengue virus serotypes.

  12. Factors determining dengue outbreak in Malaysia.

    Science.gov (United States)

    Ahmad, Rohani; Suzilah, Ismail; Wan Najdah, Wan Mohamad Ali; Topek, Omar; Mustafakamal, Ibrahim; Lee, Han Lim

    2018-01-01

    A large scale study was conducted to elucidate the true relationship among entomological, epidemiological and environmental factors that contributed to dengue outbreak in Malaysia. Two large areas (Selayang and Bandar Baru Bangi) were selected in this study based on five consecutive years of high dengue cases. Entomological data were collected using ovitraps where the number of larvae was used to reflect Aedes mosquito population size; followed by RT-PCR screening to detect and serotype dengue virus in mosquitoes. Notified cases, date of disease onset, and number and type of the interventions were used as epidemiological endpoint, while rainfall, temperature, relative humidity and air pollution index (API) were indicators for environmental data. The field study was conducted during 81 weeks of data collection. Correlation and Autoregressive Distributed Lag Model were used to determine the relationship. The study showed that, notified cases were indirectly related with the environmental data, but shifted one week, i.e. last 3 weeks positive PCR; last 4 weeks rainfall; last 3 weeks maximum relative humidity; last 3 weeks minimum and maximum temperature; and last 4 weeks air pollution index (API), respectively. Notified cases were also related with next week intervention, while conventional intervention only happened 4 weeks after larvae were found, indicating ample time for dengue transmission. Based on a significant relationship among the three factors (epidemiological, entomological and environmental), estimated Autoregressive Distributed Lag (ADL) model for both locations produced high accuracy 84.9% for Selayang and 84.1% for Bandar Baru Bangi in predicting the actual notified cases. Hence, such model can be used in forestalling dengue outbreak and acts as an early warning system. The existence of relationships among the entomological, epidemiological and environmental factors can be used to build an early warning system for the prediction of dengue outbreak so

  13. Research on Climate and Dengue in Malaysia: A Systematic Review.

    Science.gov (United States)

    Hii, Yien Ling; Zaki, Rafdzah Ahmad; Aghamohammadi, Nasrin; Rocklöv, Joacim

    2016-03-01

    Dengue is a climate-sensitive infectious disease. Climate-based dengue early warning may be a simple, low-cost, and effective tool for enhancing surveillance and control. Scientific studies on climate and dengue in local context form the basis for advancing the development of a climate-based early warning system. This study aims to review the current status of scientific studies in climate and dengue and the prospect or challenges of such research on a climate-based dengue early warning system in a dengue-endemic country, taking Malaysia as a case study. We reviewed the relationship between climate and dengue derived from statistical modeling, laboratory tests, and field studies. We searched electronic databases including PubMed, Scopus, EBSCO (MEDLINE), Web of Science, and the World Health Organization publications, and assessed climate factors and their influence on dengue cases, mosquitoes, and virus and recent development in the field of climate and dengue. Few studies in Malaysia have emphasized the relationship between climate and dengue. Climatic factors such as temperature, rainfall, and humidity are associated with dengue; however, these relationships were not consistent. Climate change projections for Malaysia show a mounting risk for dengue in the future. Scientific studies on climate and dengue enhance dengue surveillance in the long run. It is essential for institutions in Malaysia to promote research on climate and vector-borne diseases to advance the development of climate-based early warning systems. Together, effective strategies that improve existing research capacity, maximize the use of limited resources, and promote local-international partnership are crucial for sustaining research on climate and health.

  14. Dengue vaccines: Challenges, development, current status and prospects

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    A Ghosh

    2015-01-01

    Full Text Available Infection with dengue virus (DENV is the most rapidly spreading mosquito-borne viral disease in the world. The clinical spectrum of dengue, caused by any of the four serotypes of DENV, ranges from mild self-limiting dengue fever to severe dengue, in the form dengue hemorrhagic fever (DHF and dengue shock syndrome (DSS. Increased rates of hospitalization due to severe dengue, during outbreaks, result in massive economic losses and strained health services. In the absence of specific antiviral therapy, control of transmission of DENV by vector management is the sole method available for decreasing dengue-associated morbidity. Since vector control strategies alone have not been able to satisfactorily achieve reduction in viral transmission, the implementation of a safe, efficacious and cost-effective dengue vaccine as a supplementary measure is a high public health priority. However, the unique and complex immunopathology of dengue has complicated vaccine development. Dengue vaccines have also been challenged by critical issues like lack of animal models for the disease and absence of suitable markers of protective immunity. Although no licensed dengue vaccine is yet available, several vaccine candidates are under phases of development, including live attenuated virus vaccines, live chimeric virus vaccines, inactivated virus vaccines, subunit vaccines, DNA vaccines and viral-vectored vaccines. Although some vaccine candidates have progressed from animal trials to phase II and III in humans, a number of issues regarding implementation of dengue vaccine in countries like India still need to be addressed. Despite the current limitations, collaborative effects of regulatory bodies like World Health Organization with vaccine manufacturers and policy makers, to facilitate vaccine development and standardize field trials can make a safe and efficacious dengue vaccine a reality in near future.

  15. Dengue infection and miscarriage: a prospective case control study.

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    Peng Chiong Tan

    Full Text Available BACKGROUND: Dengue is the most prevalent mosquito borne infection worldwide. Vertical transmissions after maternal dengue infection to the fetus and pregnancy losses in relation to dengue illness have been reported. The relationship of dengue to miscarriage is not known. METHOD: We aimed to establish the relationship of recent dengue infection and miscarriage. Women who presented with miscarriage (up to 22 weeks gestation to our hospital were approached to participate in the study. For each case of miscarriage, we recruited 3 controls with viable pregnancies at a similar gestation. A brief questionnaire on recent febrile illness and prior dengue infection was answered. Blood was drawn from participants, processed and the frozen serum was stored. Stored sera were thawed and then tested in batches with dengue specific IgM capture ELISA, dengue non-structural protein 1 (NS1 antigen and dengue specific IgG ELISA tests. Controls remained in the analysis if their pregnancies continued beyond 22 weeks gestation. Tests were run on 116 case and 341 control sera. One case (a misdiagnosed viable early pregnancy plus 45 controls (39 lost to follow up and six subsequent late miscarriages were excluded from analysis. FINDINGS: Dengue specific IgM or dengue NS1 antigen (indicating recent dengue infection was positive in 6/115 (5·2% cases and 5/296 (1·7% controls RR 3·1 (95% CI 1·0-10 P = 0·047. Maternal age, gestational age, parity and ethnicity were dissimilar between cases and controls. After adjustments for these factors, recent dengue infection remained significantly more frequently detected in cases than controls (AOR 4·2 95% CI 1·2-14 P = 0·023. INTERPRETATION: Recent dengue infections were more frequently detected in women presenting with miscarriage than in controls whose pregnancies were viable. After adjustments for confounders, the positive association remained.

  16. Estandarización del método de centrifugación en placa para el aislamiento del virus dengue Rapid centrifugation assay standarization for dengue virus isolation

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    Miryam Palomino

    2010-03-01

    Full Text Available Se estandarizó el método de centrifugación en placa, para el aislamiento del virus dengue a partir de muestras de suero humano. Se utilizó la línea celular C6/36-HT determinándose los valores óptimos de velocidad de centrifugación, volumen de inóculo, dilución de suero y tiempo de incubación. Posteriormente, 22 muestras de suero con aislamiento viral positivo y cepas referenciales de los cuatro serotipos del virus dengue, fueron procesadas simultáneamente por el método de centrifugación en placa y el método convencional de cultivo en tubo, los aislamientos fueron tipificados mediante inmunofluorescencia indirecta empleando anticuerpos monoclonales. Se optimizó el método de centrifugación en placa inoculando 200 μL de diluciσn de suero 1/20, centrifugaciσn a 1600 rpm/30 min, presentando sensibilidad de 95,5% a cinco dνas postinoculación. Se concluye que el método de centrifugación en placa mejora el porcentaje de aislamiento, con significativa reducción en tiempo de aislamiento del virus dengue.The plate centrifugation assay was standardized for dengue virus isolation from serum samples. C6/36-HT cells were used determining the optimal values for centrifugation spin speed, inoculum, sera dilution, and incubation time. Then, 22 positive serum samples with viral isolation and viral strains of the four reference dengue virus serotypes were tested simultaneously by the standardized plate centrifugation method and the conventional tube culture. The isolations were typified by indirect immunofluorescent test using monoclonal antibodies. The plate centrifugation method was optimized to 200 μL of inoculum, dilution of sera 1/20, centrifugation speed at 1600 rpm/30 min, and sensitivity of 95,5% after 5 days post-inoculation. We concluded that the plate centrifugation method increased dengue virus isolation, with a significant reduction of the time of isolation for dengue virus.

  17. FEVER AS INDICATOR TO SECONDARY INFECTION IN DENGUE VIRAL INFECTION

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    Soegeng Soegijanto

    2018-04-01

    Full Text Available Dengue Virus Infections are distributed in tropical and sub-tropical regions and transmitted by the mosquitoes such as Aedes aegypti and Aedes albopictus. Dengue virus can cause dengue fever, dengue hemorrhagic fever and dengue shock syndrome or dengue and severe dengue classified by World Health Organization. Beside it concurrent infection virus salmonella had been found some cases who showed fever more than 7 days. Concurrent infection with two agents can result in an illness having overlapping symptoms creating a diagnostic dilemma for treating physician, such as dengue fever with typhoid fever. The aim of this research is detection of dengue virus and secondary infection with Salmonella typhi in patients suspected dengue virus infection. Detection of dengue virus and Salmonella typhi using immunochromatography test such as NS1, IgG/IgM for dengue virus infection, and IgM/IgG Salmonella and blood culture. The fifty children with dengue virus infection came to Soerya hospital and 17 cases suspected dengue virus infection, five cases showed a positive NS1 on the second day of fever and one case concurrent with clinical manifestation of convulsi on the third days of fever there were five cases only showed positive. It was showed in this study that on the fourth to six day of fever in dengue virus infection accompanied by antibody IgM & IgG dengue. There were 12 cases showed the clinical manifestation of concurrent dengue viral infection and Salmonella, all of them showed a mild clinical manifestation and did not show plasma leakage and shock. In this study we found the length of stay of concurrent Dengue Virus Infection and Salmonella infection is more than 10 days. These patients were also more likely to have co-existing haemodynamic disturbances and bacterial septicaemia which would have required treatment with inotropes and antibiotics. This idea is very important to make update dengue viral management to decrease mortality in outbreak try to

  18. Cost of dengue outbreaks: literature review and country case studies.

    Science.gov (United States)

    Stahl, Hans-Christian; Butenschoen, Vicki Marie; Tran, Hien Tinh; Gozzer, Ernesto; Skewes, Ronald; Mahendradhata, Yodi; Runge-Ranzinger, Silvia; Kroeger, Axel; Farlow, Andrew

    2013-11-06

    Dengue disease surveillance and vector surveillance are presumed to detect dengue outbreaks at an early stage and to save--through early response activities--resources, and reduce the social and economic impact of outbreaks on individuals, health systems and economies. The aim of this study is to unveil evidence on the cost of dengue outbreaks. Economic evidence on dengue outbreaks was gathered by conducting a literature review and collecting information on the costs of recent dengue outbreaks in 4 countries: Peru, Dominican Republic, Vietnam, and Indonesia. The literature review distinguished between costs of dengue illness including cost of dengue outbreaks, cost of interventions and cost-effectiveness of interventions. Seventeen publications on cost of dengue showed a large range of costs from 0.2 Million US$ in Venezuela to 135.2 Million US$ in Brazil. However, these figures were not standardized to make them comparable. Furthermore, dengue outbreak costs are calculated differently across the publications, and cost of dengue illness is used interchangeably with cost of dengue outbreaks. Only one paper from Australia analysed the resources saved through active dengue surveillance. Costs of vector control interventions have been reported in 4 studies, indicating that the costs of such interventions are lower than those of actual outbreaks. Nine papers focussed on the cost-effectiveness of dengue vaccines or dengue vector control; they do not provide any direct information on cost of dengue outbreaks, but their modelling methodologies could guide future research on cost-effectiveness of national surveillance systems.The country case studies--conducted in very different geographic and health system settings - unveiled rough estimates for 2011 outbreak costs of: 12 million US$ in Vietnam, 6.75 million US$ in Indonesia, 4.5 million US$ in Peru and 2.8 million US$ in Dominican Republic (all in 2012 US$). The proportions of the different cost components (vector control

  19. Cost of dengue outbreaks: literature review and country case studies

    Science.gov (United States)

    2013-01-01

    Background Dengue disease surveillance and vector surveillance are presumed to detect dengue outbreaks at an early stage and to save – through early response activities – resources, and reduce the social and economic impact of outbreaks on individuals, health systems and economies. The aim of this study is to unveil evidence on the cost of dengue outbreaks. Methods Economic evidence on dengue outbreaks was gathered by conducting a literature review and collecting information on the costs of recent dengue outbreaks in 4 countries: Peru, Dominican Republic, Vietnam, and Indonesia. The literature review distinguished between costs of dengue illness including cost of dengue outbreaks, cost of interventions and cost-effectiveness of interventions. Results Seventeen publications on cost of dengue showed a large range of costs from 0.2 Million US$ in Venezuela to 135.2 Million US$ in Brazil. However, these figures were not standardized to make them comparable. Furthermore, dengue outbreak costs are calculated differently across the publications, and cost of dengue illness is used interchangeably with cost of dengue outbreaks. Only one paper from Australia analysed the resources saved through active dengue surveillance. Costs of vector control interventions have been reported in 4 studies, indicating that the costs of such interventions are lower than those of actual outbreaks. Nine papers focussed on the cost-effectiveness of dengue vaccines or dengue vector control; they do not provide any direct information on cost of dengue outbreaks, but their modelling methodologies could guide future research on cost-effectiveness of national surveillance systems. The country case studies – conducted in very different geographic and health system settings - unveiled rough estimates for 2011 outbreak costs of: 12 million US$ in Vietnam, 6.75 million US$ in Indonesia, 4.5 million US$ in Peru and 2.8 million US$ in Dominican Republic (all in 2012 US$). The proportions of the

  20. Evaluation of laboratory tests for dengue diagnosis in clinical specimens from consecutive patients with suspected dengue in Belo Horizonte, Brazil.

    Science.gov (United States)

    Ferraz, Fernanda Oliveira; Bomfim, Maria Rosa Quaresma; Totola, Antônio Helvécio; Ávila, Thiago Vinícius; Cisalpino, Daniel; Pessanha, José Eduardo Marques; da Glória de Souza, Danielle; Teixeira Júnior, Antônio Lúcio; Nogueira, Maurício Lacerda; Bruna-Romero, Oscar; Teixeira, Mauro Martins

    2013-09-01

    Dengue is a widely spread arboviral disease in tropical and subtropical regions of the world. Dengue fever presents clinical characteristics similar to other febrile illness. Thus laboratory diagnosis is important for adequate management of the disease. The present study was designed to evaluate the diagnostic performance of real-time PCR and serological methods for dengue in a real epidemic context. Clinical data and blood samples were collected from consecutive patients with suspected dengue who attended a primary health care unit in Belo Horizonte, Brazil. Serologic methods and real-time PCR were performed in serum samples to confirm dengue diagnosis. Among the 181 consecutive patients enrolled in this study with suspected dengue, 146 were considered positive by serological criteria (positive NS1 ELISA and/or anti-dengue IgM ELISA) and 138 were positive by real-time PCR. Clinical criteria were not sufficient for distinguishing between dengue and non-dengue febrile illness. The PCR reaction was pre-optimized using samples from patients with known viral infection. It had similar sensitivity compared to NS1 ELISA (88% and 89%, respectively). We also evaluated three commercial lateral flow immunochromatographic tests for NS1 detection (BIOEASY, BIORAD and PANBIO). All three tests showed high sensitivity (94%, 91% and 81%, respectively) for dengue diagnosis. According to our results it can be suggested that lateral flow tests for NS1 detection are the most feasible methods for early diagnosis of dengue. Copyright © 2013 Elsevier B.V. All rights reserved.

  1. Bartonellosis en Colombia, bartonellosis de guáitara ó fiebre verrucosa del guáitara

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    Luis Patiño Camargo

    1939-04-01

    Full Text Available Desde principios de 1936 las autoridades de Nariño venían seriamente preocupadas por una mortífera enfermedad epidémica aparecida al Norte en vertientes de juanambu y del rio Mayo, enfermedad que de improviso se presentó en el Guáitara con gran virulencia. El médico doctor Max Llorente, Gobernador entonces del Departamento, inspeccionó con el Director de Higiene la zona invadida, y a su regreso a Pasto conferencio con el Colegio Médico. En la reunión se acogió el diagnostico de paludismo agudo pernicioso. Como resultado se organizó una comisión de tratamiento encabezada por un médico, y se situó en Ancuya. Por esos días el Departamento Nacional de Higiene envió un ingeniero sanitario, quien recorrió las comarcas atacadas y rindió un informe.

  2. Manifestaciones cardiacas del dengue: Reporte de una serie de casos durante la epidemia colombiana de 2010

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    Clara Saldarriaga G.

    2013-12-01

    Full Text Available INTRODUCCIÓN: el dengue es la enfermedad viral transmitida por vectores de diseminación más frecuente en el mundo. Su espectro clínico incluye las manifestaciones atípicas, entre ellas el compromiso cardiaco, del cual sólo se han reportado pocas series de casos en la literatura. OBJETIVO: reportar las características clínicas de los pacientes atendidos por casos confirmados por serología de dengue con manifestaciones cardiovasculares en un centro de referencia cardiovascular colombiano durante la epidemia de 2010. METODOLOGÍA: estudio observacional, descriptivo, prospectivo, en el que se incluyeron los pacientes que consultaron al servicio de urgencias, a quienes se les realizó un diagnóstico confirmado de dengue y tuvieron manifestaciones cardiovasculares de la enfermedad. RESULTADOS: se encontraron 7 pacientes; el 50% no tenía antecedentes previos de enfermedad cardiovascular. Los trastornos del ritmo fueron la manifestación cardiaca más frecuente (42,8%, entre ellos la fibrilación auricular de novo (14,2%, el bloqueo auriculoventricular completo y transitorio (14,2%, la bradicardia sinusal concomitante con derrame pericárdico (14,2% y la disfunción ventricular leve (28,5%; un paciente presentó un síndrome coronario agudo con elevación de ST durante la infección y dos descompensación aguda de insuficiencia cardiaca. No se reportaron muertes. CONCLUSIÓN: la incidencia de las complicaciones cardiacas asociadas a la infección por dengue varía de una serie a otra y su fisiopatología no se conoce por completo. Durante la epidemia que se desató en Colombia en 2010 se encontraron pocos casos de manifestaciones cardiovasculares pero con una morbilidad importante que debe alertar respecto a su identificación temprana.

  3. Nociones populares sobre "dengue" y "rompehuesos", dos modelos de la enfermedad en Colombia

    OpenAIRE

    Fajardo Paulina; Monje Carlos Arturo; Lozano Gladys; Realpe Orlando; Hernández Luis Eduardo

    2001-01-01

    Objetivo. Hacer llegar a través de los niños mensajes educativos a las familias en Neiva, capital del Departamento del Huila, Colombia. Métodos. Se desarrolló un proyecto educativo para incluir en el currículo de Ciencias Naturales y Educación Ambiental de los escolares de educación básica contenidos sobre el dengue, el vector y su control. Mediante encuestas y escalas tipo Likert se determinaron los conocimientos y las actitudes en los hogares de los escolares, y luego se complementaron con ...

  4. Aedes mosquito salivary immune peptides: boost or block dengue viral infections

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    Natthanej Luplertlop

    2014-02-01

    Full Text Available Dengue virus, one of the most important arthropod-borne viruses, infected to human can severely cause dengue hemorrhagic fever and dengue shock syndrome. There are expected about 50 million dengue infections and 500 000 individuals are hospitalized with dengue hemorrhagic fever, mainly in Southeast Asia, Pacific, and in Americas reported each year. The rapid expansion of global dengue is one of a major public health challenge, together with not yet successful solutions of dengue epidemic control strategies. Thus, these dynamic dengue viral infections exhibited high demographic, societal, and public health infrastructure impacts on human. This review aimed to highlight the current understanding of dengue mosquito immune responses and role of mosquito salivary glands on dengue infection. These information may provide a valuable knowledge of disease pathogenesis, especially in mosquito vector and dengue virus interaction, which may help to control and prevent dengue distribution.

  5. Adherencia de los pacientes a la Guía de Práctica Clínica del Dengue (GPC_Dengue en una Clínica de Barranquilla (Atl, Col

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    J Rodríguez López

    2015-07-01

    Full Text Available Resumen – El Dengue es una enfermedad transmitida por la picadura de un mosquito Aedes. En Colombia representa un problema en salud pública debido a la re emergencia e intensa transmisión con tendencia creciente, el comportamiento de ciclos epidémicos cada dos o tres años. Objetivo. Caracterizar la adherencia de los Profesionales médicos de la Salud, la guía para la atención clínica integral del paciente con dengue (GPC_Dengue OPS/OMS 2010, Clínica de la Policía Regional Caribe Barranquilla, de enero a diciembre 2013. Materiales y Métodos. Fue Cuantitativa, descriptiva transversal. La muestra estuvo conformada por 83 historias clínicas, donde se confirmaron los casos de dengue en la institución, se aplicó un cuestionario y los resultados se establecieron en medidas de tendencia central, para comparar el nivel de adherencia de los aspectos de Evaluación General, Diagnóstico y Clasificación, Manejo a la GPC_Dengue, se realizó un análisis de varianza no paramétrico, Test Kruskall-Wallis. Y una prueba de Tendencia Lineal. Resultados. Se observó que la proporción de hombres y mujeres fue prácticamente 1:1, la adherencia en general fue Adecuada para los ítems evaluados. No se encontró una diferencia entre la adherencia para cada uno de los criterios evaluados. Los resultados fueron coherentes con otros estudios. Conclusiones. El nivel de adherencia global estuvo iguales para ambos tipos de hospitalización, tanto para el nivel de adherencia Muy Bueno, Bueno y Regular; mayoritariamente, los profesionales tuvieron una Buena adherencia a la GPC_Dengue, es probable que esta adherencia sea haya dado por el nivel de la clínica.

  6. Dengue and dengue hemorrhagic fever in the Americas: lessons and challenges.

    Science.gov (United States)

    Guzman, María G; Kouri, Gustavo

    2003-05-01

    The incidence of dengue and dengue hemorrhagic fever (DF/DHF) has increased significantly over the last decades. Yearly, an estimated 50-100 million cases of DF and about 250000-500000 cases of DHF occur worldwide. The epidemiological situation in Latin America now resembles that in Southeast Asia. Here, the main clinical, epidemiological and virological observations in the American region are presented and compared with those previously reported from Southeast Asia. During 2002, more than 30 Latin American countries reported over 1000000 DF cases. DHF occurred in 20 countries with more than 17000 DHF cases, including 225 fatalities. The co-circulation of multiple serotypes has been reported from many countries. In the Americas, DHF is observed both in children and adults; secondary infection by a different dengue virus serotype has been confirmed as an important risk factor for this severe form of the disease. However, some new risk factors such as the interval of dengue virus infections and the ethnicity and underlying chronic conditions of the patient have also been identified. The sequence of dengue virus infections and association with certain genotypes are further factors of importance. We also discuss the control and prevention strategies. In conclusion, without urgent action for the prevention and control of dengue/DHF and its vector, the current situation will worsen and, more dramatical, there is a risk of the urbanization of yellow fever.

  7. System Dynamics based Dengue modeling environment to simulate evolution of Dengue infection under different climate scenarios

    Science.gov (United States)

    Anwar, R.; Khan, R.; Usmani, M.; Colwell, R. R.; Jutla, A.

    2017-12-01

    Vector borne infectious diseases such as Dengue, Zika and Chikungunya remain a public health threat. An estimate of the World Health Organization (WHO) suggests that about 2.5 billion people, representing ca. 40% of human population,are at increased risk of dengue; with more than 100 million infection cases every year. Vector-borne infections cannot be eradicated since disease causing pathogens survive in the environment. Over the last few decades dengue infection has been reported in more than 100 countries and is expanding geographically. Female Ae. Aegypti mosquito, the daytime active and a major vector for dengue virus, is associated with urban population density and regional climatic processes. However, mathematical quantification of relationships on abundance of vectors and climatic processes remain a challenge, particularly in regions where such data are not routinely collected. Here, using system dynamics based feedback mechanism, an algorithm integrating knowledge from entomological, meteorological and epidemiological processes is developed that has potential to provide ensemble simulations on risk of occurrence of dengue infection in human population. Using dataset from satellite remote sensing, the algorithm was calibrated and validated using actual dengue case data of Iquitos, Peru. We will show results on model capabilities in capturing initiation and peak in the observed time series. In addition, results from several simulation scenarios under different climatic conditions will be discussed.

  8. Penentuan Serotipe Virus Dengue dan Gambaran Manifestasi Klinis serta Hematologi Rutin pada Infeksi Virus Dengue

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    Basti Andriyoko

    2012-12-01

    Full Text Available All DENV serotypes can cause a spectrum of disease from dengue fever (DF to dengue hemorrhagic fever (DHF and dengue shock syndrome (DSS. It is difficult to differentiate clinical characteristicand hematologic result for each serotype. Aim of this study were to determine dengue serotype and describe clinical manifestation of DF, DHF, DSS and routine hematologic results, i.e.haemoglobin, hematocrit, leukocyte, and thrombocyte in each serotype. This study was conducted at Dr. Hasan Sadikin Hospital Bandung from March 2010 until July 2011. Subjects were dengue patients aged >14 years with a history of fever <5 days. Blood samples were taken for serotype determination by reverse transcription polymerase chain reaction (RT-PCR followed by semi-nested PCR. Clinical manifestation data and haematologic result were obtained from medical records. This was a descriptive study. Seventy five patients were included in this study. Dengue serotype can be detected in 27 (36% samples with DENV-3 (13 were dominating followed by DENV-2 (8, DENV-4 (4, and DENV-1 (2. DHF was mainly found in DENV-3. DENV-2 gavethe highest decrease in hemoglobin, highest percentage increase in haematocrit, lowest leukocyte, and lowest thrombocyte. In conclusion, all 4 serotypes are found in RSUP Dr. Hasan Sadikin Hospital Bandung with DENV-3 domination. DHF is mainly caused by DENV-3.

  9. Manifestaciones clínicas inusuales del dengue hemorrágico en niños.

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    Angela Méndez

    2006-03-01

    Full Text Available Introducción. Recientemente han venido aumentando los reportes de dengue hemorrágico con manifestaciones inusuales, principalmente neurológicas y hepáticas, que aumentan la morbimortalidad. Objetivo. Describir las manifestaciones inusuales del dengue hemorrágico en niños. Materiales y métodos. En el Departamento de Pediatría del Hospital Universitario de Santander en Bucaramanga, Colombia, de 913 pacientes con diagnóstico de dengue hemorrágico entre 1992 y 2004, se seleccionaron aquéllos que presentaron manifestaciones inusuales. Se clasificaron de acuerdo con los criterios de definición de caso, se agruparon según los órganos o sistemas principalmente comprometidos y se describieron los principales hallazgos clínicos, de laboratorio y relativos a la evolución. Resultados. Se encontraron 168 pacientes que presentaron manifestaciones inusuales, con predominio del sexo masculino, edad escolar y grados III y IV de dengue hemorrágico. Las manifestaciones más frecuentes fueron hepáticas, 53 (27%, y neurológicas, 49 (25%, además de renales, 14 (7%; cardíacas, 15 (8%; pulmonares, 18 (9%; colecistitis alitiásica, 18 (9%; síndrome hemofagocítico, 5 (2,5%; pancreatitis, 2 (1%, y 21 casos de abdomen agudo (11%. Fallecieron 10 pacientes. Conclusión. Se analizan los resultados y se comparan con otros de países endemoepidémicos de dengue; se discute el significado e importancia de las manifestaciones clínicas inusuales, su difícil diagnóstico, casi siempre en forma retrospectiva, y se destaca la frecuencia de las manifestaciones hepáticas y neurológicas que pueden aumentar la morbimortalidad, ante las cuales deben estar alertas los médicos que trabajan en zonas endémicas para reconocerlas.

  10. The prevention and control of dengue after Typhoon Haiyan

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    Charito Aumentado

    2015-11-01

    Full Text Available Objective: Many of the areas in the Philippines affected by Typhoon Haiyan are endemic for dengue; therefore, dengue prevention was a priority in the initial post-disaster risk assessment. We describe the dengue prevention and response strategies applied after Haiyan. Methods: The dengue response was implemented by a wide range of national and international stakeholders. Priorities included the rapid re-establishment of an effective surveillance system to quickly identify new dengue cases, monitor trends and determine the geographical distribution of cases. Dengue rapid diagnostic tests (RDTs were distributed to sentinel health facilities, and comprehensive vector control activities and entomological surveys were implemented. Several training sessions for key stakeholders and awareness campaigns for communities were organized. Results: There were RDT-positive dengue cases reported from urban and semi-urban areas where entomological surveys also confirmed a high density of Aedes aegypti mosquitoes. Although there was an increase in dengue cases in January 2014, the number of cases remained below the epidemic threshold throughout the remaining months of 2014. Discussion: There was no large outbreak of dengue after Typhoon Haiyan, possibly due to the targeted, multifaceted and rapid response for dengue after Haiyan. However, surveillance differed after Haiyan, making comparisons with previous years difficult. Multiple players contributed to the response that was also facilitated by close communication and coordination within the Health Cluster.

  11. Cost of Dengue Vector Control Activities in Malaysia

    Science.gov (United States)

    Packierisamy, P. Raviwharmman; Ng, Chiu-Wan; Dahlui, Maznah; Inbaraj, Jonathan; Balan, Venugopalan K.; Halasa, Yara A.; Shepard, Donald S.

    2015-01-01

    Dengue fever, an arbovirus disease transmitted by Aedes mosquitoes, has recently spread rapidly, especially in the tropical countries of the Americas and Asia-Pacific regions. It is endemic in Malaysia, with an annual average of 37,937 reported dengue cases from 2007 to 2012. This study measured the overall economic impact of dengue in Malaysia, and estimated the costs of dengue prevention. In 2010, Malaysia spent US$73.5 million or 0.03% of the country's GDP on its National Dengue Vector Control Program. This spending represented US$1,591 per reported dengue case and US$2.68 per capita population. Most (92.2%) of this spending occurred in districts, primarily for fogging. A previous paper estimated the annual cost of dengue illness in the country at US$102.2 million. Thus, the inclusion of preventive activities increases the substantial estimated cost of dengue to US$175.7 million, or 72% above illness costs alone. If innovative technologies for dengue vector control prove efficacious, and a dengue vaccine was introduced, substantial existing spending could be rechanneled to fund them. PMID:26416116

  12. Cost of Dengue Vector Control Activities in Malaysia.

    Science.gov (United States)

    Packierisamy, P Raviwharmman; Ng, Chiu-Wan; Dahlui, Maznah; Inbaraj, Jonathan; Balan, Venugopalan K; Halasa, Yara A; Shepard, Donald S

    2015-11-01

    Dengue fever, an arbovirus disease transmitted by Aedes mosquitoes, has recently spread rapidly, especially in the tropical countries of the Americas and Asia-Pacific regions. It is endemic in Malaysia, with an annual average of 37,937 reported dengue cases from 2007 to 2012. This study measured the overall economic impact of dengue in Malaysia, and estimated the costs of dengue prevention. In 2010, Malaysia spent US$73.5 million or 0.03% of the country's GDP on its National Dengue Vector Control Program. This spending represented US$1,591 per reported dengue case and US$2.68 per capita population. Most (92.2%) of this spending occurred in districts, primarily for fogging. A previous paper estimated the annual cost of dengue illness in the country at US$102.2 million. Thus, the inclusion of preventive activities increases the substantial estimated cost of dengue to US$175.7 million, or 72% above illness costs alone. If innovative technologies for dengue vector control prove efficacious, and a dengue vaccine was introduced, substantial existing spending could be rechanneled to fund them. © The American Society of Tropical Medicine and Hygiene.

  13. Risk factors for concurrent bacteremia in adult patients with dengue.

    Science.gov (United States)

    Thein, Tun-Linn; Ng, Ee-Ling; Yeang, Ming S; Leo, Yee-Sin; Lye, David C

    2017-06-01

    Bacteremia in dengue may occur with common exposure to pathogens in association with severe organ impairment or severe dengue, which may result in death. Cohort studies identifying risk factors for concurrent bacteremia among patients with dengue are rare. We conducted a retrospective case-control study of adult patients with dengue who were admitted to the Department of Infectious Diseases at Tan Tock Seng Hospital, Singapore from 2004 to 2008. For each case of dengue with concurrent bacteremia (within the first 72 hours of admission), we selected four controls without bacteremia, who were matched on year of infection and dengue confirmation method. Conditional logistic regression was performed to identify risk factors for concurrent bacteremia. Among 9,553 patients with dengue, 29 (0.3%) had bacteremia. Eighteen of these patients (62.1%) had concurrent bacteremia. The predominant bacteria were Staphylococcus aureus, one of which was a methicillin-resistant strain. Dengue shock syndrome occurred more frequently and hospital stay was longer among cases than among controls. Three cases did not survive, whereas none of the controls died. In multivariate analysis, being critically ill at hospital presentation was independently associated with 15 times the likelihood of a patient with dengue having concurrent bacteremia. Concurrent bacteremia in adult patients with dengue is uncommon but presents atypically and results in more deaths and longer hospital stay. Given the associated mortality, collection of blood cultures and empiric antibiotic therapy may be considered in patients who are critically ill. Copyright © 2015. Published by Elsevier B.V.

  14. A brief review on dengue molecular virology, diagnosis, treatment and prevalence in Pakistan

    OpenAIRE

    Idrees, Sobia; Ashfaq, Usman A

    2012-01-01

    Dengue virus infection is a serious health problem infecting 2.5 billion people worldwide. Dengue is now endemic in more than 100 countries, including Pakistan. Each year hundreds of people get infected with dengue in Pakistan. Currently, there is no vaccine available for the prevention of Dengue virus infection due to four viral serotypes. Dengue infection can cause death of patients in its most severity, meanwhile many antiviral compounds are being tested against dengue virus infection to e...

  15. CARACTERIZACIÓN BIOLÓGICA DE VARIANTES DE PLACA DE LA CEPA VACUNAL 17D CONTRA LA FIEBRE AMARILLA

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    María Rojas

    2009-09-01

    Full Text Available La vacuna colombiana 17D, contiene por lo menos cuatro fenotipos, denominados pequeño (0.3 – 1.2 mm, mediano (1.3 – 2.1 mm, grande (2.2 – 3.0 mm y extragrande (>3.1 mm. La composición y distribución porcentual de esos fenotipos, varió entre lotes y entre ampolletas de un mismo lote. Cada variante fue clonada por dilución de la vacuna y su efecto virulento fue analizado en ratones; el fenotipo de placa pequeño estuvo ligeramente sub representado en los lotes analizados y mostró una virulencia similar a la de la cepa silvestre neurotrópica Francesa (LD50 > 10-6, mientras que el fenotipo predominante y mas atenuado fue el mediano (LD50: 10-4. Los fenotipos grande y extragrande mostraron una virulencia intermedia (LD 50: 10 – 5  con relación a los anteriores. Los análisis de secuencia de las variantes sobre una región comprendida entre el extremo 3´NS5 y el inicio de 3´NCR, mostró la cercanía entre aquellas variantes con algún grado de virulencia, y entre la variante atenuada y la vacuna colombiana. La heterogeneidad de la vacuna 17D, constituye una evidencia de la estructura de quasiespecies propia de los virus RNA y señala cómo los casos de reacciones post vacunales  adversas pueden estar asociados con la aplicación de vacunas fabricadas a partir de cepas virales atenuadas.  

  16. Dengue Fever in the United States

    Centers for Disease Control (CDC) Podcasts

    2012-04-09

    Dr. Amesh Adalja, an associate at the Center for Biosecurity and clinical assistant professor at the University of Pittsburgh School, of Medicine, discusses dengue fever outbreaks in the United States.  Created: 4/9/2012 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 4/16/2012.

  17. Multiobjective Genetic Algorithm applied to dengue control.

    Science.gov (United States)

    Florentino, Helenice O; Cantane, Daniela R; Santos, Fernando L P; Bannwart, Bettina F

    2014-12-01

    Dengue fever is an infectious disease caused by a virus of the Flaviridae family and transmitted to the person by a mosquito of the genus Aedes aegypti. This disease has been a global public health problem because a single mosquito can infect up to 300 people and between 50 and 100 million people are infected annually on all continents. Thus, dengue fever is currently a subject of research, whether in the search for vaccines and treatments for the disease or efficient and economical forms of mosquito control. The current study aims to study techniques of multiobjective optimization to assist in solving problems involving the control of the mosquito that transmits dengue fever. The population dynamics of the mosquito is studied in order to understand the epidemic phenomenon and suggest strategies of multiobjective programming for mosquito control. A Multiobjective Genetic Algorithm (MGA_DENGUE) is proposed to solve the optimization model treated here and we discuss the computational results obtained from the application of this technique. Copyright © 2014 Elsevier Inc. All rights reserved.

  18. Dengue vaccine: come let's fight the menace.

    Science.gov (United States)

    Chawla, Sumit; Sahoo, Soumya Swaroop; Singh, Inderjeet; Verma, Madhur; Gupta, Vikas; Kumari, Sneh

    2015-01-01

    Although dengue has a global distribution, the World Health Organization (WHO) South-East Asia region together with Western Pacific region bears nearly 75% of the current global disease burden. Globally, the societal burden has been estimated to be approximately 528 to 1300 disability-adjusted life years (DALY) per million to populations in endemic regions Dengue is believed to infect 50 to 100 million people worldwide a year with half a million life-threatening infections requiring hospitalization, resulting in approximately 12,500 to 25,000 deaths. Despite being known for decades and nearly half the world's population is at risk for infection with as many as 100 million cases occurring annually, the pitiable state is that we still have no antiviral drugs to treat it and no vaccines to prevent it. In recent years, however, the development of dengue vaccines has accelerated dramatically in tandem with the burgeoning dengue problem with a rejuvenated vigour. However, recent progress in molecular-based vaccine strategies, as well as a renewed commitment by the World Health Organization (WHO) to co-ordinate global efforts on vaccine development, finally provides hope that control of this serious disease may be at hand. Today, several vaccines are in various stages of advanced development, with clinical trials currently underway on 5 candidate vaccines. Trials in the most advanced stages are showing encouraging preliminary data, and the leading candidate could be licensed as early as 2015.

  19. Dengue fever | Tavodova | South Sudan Medical Journal

    African Journals Online (AJOL)

    South Sudan Medical Journal. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 5, No 1 (2012) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. Dengue fever. Milada Tavodova. Abstract. No Abstract ...

  20. Immature dengue virus: a veiled pathogen?

    Directory of Open Access Journals (Sweden)

    Izabela A Rodenhuis-Zybert

    2010-01-01

    Full Text Available Cells infected with dengue virus release a high proportion of immature prM-containing virions. In accordance, substantial levels of prM antibodies are found in sera of infected humans. Furthermore, it has been recently described that the rates of prM antibody responses are significantly higher in patients with secondary infection compared to those with primary infection. This suggests that immature dengue virus may play a role in disease pathogenesis. Interestingly, however, numerous functional studies have revealed that immature particles lack the ability to infect cells. In this report, we show that fully immature dengue particles become highly infectious upon interaction with prM antibodies. We demonstrate that prM antibodies facilitate efficient binding and cell entry of immature particles into Fc-receptor-expressing cells. In addition, enzymatic activity of furin is critical to render the internalized immature virus infectious. Together, these data suggest that during a secondary infection or primary infection of infants born to dengue-immune mothers, immature particles have the potential to be highly infectious and hence may contribute to the development of severe disease.

  1. Dengue Virus Genome Uncoating Requires Ubiquitination

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    Laura A. Byk

    2016-06-01

    Full Text Available The process of genome release or uncoating after viral entry is one of the least-studied steps in the flavivirus life cycle. Flaviviruses are mainly arthropod-borne viruses, including emerging and reemerging pathogens such as dengue, Zika, and West Nile viruses. Currently, dengue virus is one of the most significant human viral pathogens transmitted by mosquitoes and is responsible for about 390 million infections every year around the world. Here, we examined for the first time molecular aspects of dengue virus genome uncoating. We followed the fate of the capsid protein and RNA genome early during infection and found that capsid is degraded after viral internalization by the host ubiquitin-proteasome system. However, proteasome activity and capsid degradation were not necessary to free the genome for initial viral translation. Unexpectedly, genome uncoating was blocked by inhibiting ubiquitination. Using different assays to bypass entry and evaluate the first rounds of viral translation, a narrow window of time during infection that requires ubiquitination but not proteasome activity was identified. In this regard, ubiquitin E1-activating enzyme inhibition was sufficient to stabilize the incoming viral genome in the cytoplasm of infected cells, causing its retention in either endosomes or nucleocapsids. Our data support a model in which dengue virus genome uncoating requires a nondegradative ubiquitination step, providing new insights into this crucial but understudied viral process.

  2. Dengue in the elderly: a review.

    Science.gov (United States)

    Lin, Ray Junhao; Lee, Tau Hong; Leo, Yee Sin

    2017-08-01

    Changing dengue epidemiological trends have resulted in a shift in the disease burden to the adult population. Older adults suffer from poorer outcomes as compared to their younger counterparts, making clinical management of this sub-population particularly challenging. Areas covered: We present a review of the current literature on the changing epidemiology of dengue in the elderly, the atypical features of the clinical disease in this population with emphasis on severe disease presentations and challenges in the current management strategies. Expert commentary: Dengue in the elderly is an increasingly important yet greatly understudied area. There is an urgent need to refine the current diagnostic criteria to improve diagnosis, classification of disease severity and identify individuals in this population who are likely to progress to severe disease. Management strategies in this population would have to be adjusted to account for the increased number of co-morbidities. The role of the available dengue vaccines in this group is uncertain, and more studies into their safety and efficacy are critically needed.

  3. Epidemiología de la fiebre amarilla selvatica en Colombia durante los ultimos años

    Directory of Open Access Journals (Sweden)

    Jorge Boshell Manrique

    1997-12-01

    Full Text Available Los estudios y observaciones en que se basa este informe se llevaron a cabo bajo los auspicios de la Sección de Estudios Especiales del Ministerio de Trabajo, Higiene y Previsión Social de Colombia, en cooperación con la División Sanitaria Internacional de la Fundación Rockefeller. Un informe más detallado fue publicado en inglés, en el ""American Journal of Hygiene. Vol. 39. N° 1. Enero, 1944

  4. Manifestações mucocutâneas da dengue Mucocutaneous manifestations of dengue

    Directory of Open Access Journals (Sweden)

    Omar Lupi

    2007-08-01

    Full Text Available Dengue é doença viral sistêmica que ocorre de forma epidêmica em áreas tropicais e subtropicais da Ásia, Américas e África. O vírus da dengue pertence ao gênero Flavivirus e à família Flaviviridae (arbovírus do grupo B. Aedes aegypti é o principal vetor e verdadeiro reservatório. A febre na dengue clássica persiste por período de dois a cinco dias com cefaléia intensa, mialgia, artralgia e dor retro-orbital. Alterações cutâneas incluem diversos achados como erupção morbiliforme que pode ser pruriginosa e que gera descamação residual, algumas manifestações hemorrágicas discretas como epistaxe, petéquias e sangramento gengival. Extravasamento capilar de plasma é responsável pela hemoconcentração e trombocitopenia observadas e que caracterizam a dengue hemorrágica. Manifestações cutâneas da dengue hemorrágica incluem lesões hemorrágicas disseminadas como petéquias e equimoses, mas também instabilidade hemodinâmica com pulso filiforme, pressão arterial convergente, extremidades frias, confusão mental e choque.Dengue fever is a systemic viral disease that occurs epidemically in tropical and subtropical regions of Asia, Americas and Africa. The dengue virus belongs to the genus Flavivirus of the family Flaviviridae (group B arbovirus. Aedes aegypti is the major vector and the true reservoir for the virus. Classic dengue fever lasts for two-five days, with severe headache, intense myalgia, arthralgia and retro-orbital pain. Cutaneous alterations include several findings such as a diffuse morbilliform rash that may be pruritic and heals with desquamation, and minor bleeding phenomena such as epistaxis, petechiae, and gingival bleeding. Diffuse capillary leakage of plasma is responsible for the hemoconcentration and thrombocytopenia that characterize dengue hemorrhagic fever. Cutaneous manifestations of dengue hemorrhagic fever include many disseminated hemorrhagic lesions such as petechiae and ecchymoses, but

  5. A epidemia de dengue/dengue hemorrágico no município do Rio de Janeiro, 2001/2002 The epidemic of dengue and hemorrhagic dengue fever in the city of Rio de Janeiro, 2001/2002

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    Clarisse Guimarães Casali

    2004-08-01

    Full Text Available O objetivo deste estudo foi avaliar a ocorrência dos principais sinais e sintomas dos casos de dengue clássico e dengue hemorrágico na epidemia de 2001-2002 do município do Rio de Janeiro. Foram analisados os 155.242 casos notificados ao Sistema de Informações de Agravos de Notificação, desde janeiro/2001, até junho/2002; deste total, excluindo-se os ignorados, 81.327 casos foram classificados como dengue clássico e 958 como dengue hemorrágico, com um total de 54 óbitos. Avaliaram-se as variáveis referentes à sintomatologia da doença. Manifestações gerais como febre, cefaléia, prostração, mialgia, náuseas e dor retro-orbitária tiveram alta incidência tanto no dengue clássico como no dengue hemorrágico. Por outro lado, manifestações hemorrágicas e algumas de maior gravidade como choque, hemorragia digestiva, petéquias, epistaxe, dor abdominal e derrame pleural, estiveram significativamente associadas ao dengue hemorrágico. Além disso, a evolução do quadro clínico para o óbito foi 34,8 vezes maior no dengue hemorrágico que no dengue clássico (OR=34,8; IC 19,7-61,3.The following study was intended to evaluate the occurrence of typical signs and symptoms in the cases of classic dengue and hemorrhagic dengue fever, during the 2001-2002 epidemic in the city of Rio de Janeiro. The authors reviewed 155,242 cases notified to the Information System of Notification Diseases, from January/2001 to June/2002: 81,327 cases were classified as classic dengue and 958 as hemorrhagic dengue fever, with a total of 60 deaths. Common symptoms, such as fever, headache, prostration, myalgia, nausea and retro-orbital pain, had a high incidence in both classic and hemorrhagic dengue fever. On the other hand, hemorrhagic signs and other signs of severe disease, such as shock, gastrointestinal bleeding, petechiae, epistaxis, abdominal pain and pleural effusion, were strongly associated to hemorrhagic dengue fever. Besides, the occurrence

  6. Acute neuromuscular weakness associated with dengue infection

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    Harmanjit Singh Hira

    2012-01-01

    Full Text Available Background: Dengue infections may present with neurological complications. Whether these are due to neuromuscular disease or electrolyte imbalance is unclear. Materials and Methods: Eighty-eight patients of dengue fever required hospitalization during epidemic in year 2010. Twelve of them presented with acute neuromuscular weakness. We enrolled them for study. Diagnosis of dengue infection based on clinical profile of patients, positive serum IgM ELISA, NS1 antigen, and sero-typing. Complete hemogram, kidney and liver functions, serum electrolytes, and creatine phosphokinase (CPK were tested. In addition, two patients underwent nerve conduction velocity (NCV test and electromyography. Results: Twelve patients were included in the present study. Their age was between 18 and 34 years. Fever, myalgia, and motor weakness of limbs were most common presenting symptoms. Motor weakness developed on 2 nd to 4 th day of illness in 11 of 12 patients. In one patient, it developed on 10 th day of illness. Ten of 12 showed hypokalemia. One was of Guillain-Barré syndrome and other suffered from myositis; they underwent NCV and electromyography. Serum CPK and SGOT raised in 8 out of 12 patients. CPK of patient of myositis was 5098 IU. All of 12 patients had thrombocytopenia. WBC was in normal range. Dengue virus was isolated in three patients, and it was of serotype 1. CSF was normal in all. Within 24 hours, those with hypokalemia recovered by potassium correction. Conclusions: It was concluded that the dengue virus infection led to acute neuromuscular weakness because of hypokalemia, myositis, and Guillain-Barré syndrome. It was suggested to look for presence of hypokalemia in such patients.

  7. Síntesis in vitro de la proteína de la envoltura del virus peruano de la fiebre amarilla

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    Carlos Yábar V

    2001-01-01

    Full Text Available Objetivo: Sintetizar la proteína recombinante de la envoltura (Er del virus peruano de la Fiebre Amarilla (FA utilizando técnicas moleculares. Materiales y métodos: El gen de la proteína de interés fue amplificado por transcripción reversa - reacción en cadena de la polimerasa (RT-PCR y clonado en un vector plasmídico para ser analizado mediante secuenciamiento de ADN. El inserto de ADN fue subdonado en un vector de expresión para ser traducido a proteína. Se purificó la proteína mediante cromatografía de afinidad bajo condiciones denaturantes, siendo visualizada por electroforesis en SDS-PAGE. Resultados: Se sintetizó y purificó la pr E del virus de la FA. Presentó un peso de 66 kDa, y luego de tres horas de inducción a partir de 1x108 células (OD=0.5 se obtuvo 10 mg/mL de la proteína a miniescala. Conclusión: El análisis de la secuencia de aminoácidos demostró que Er podría ser un buen candidato a ser evaluado serológicamente y luego ser usado como herramienta de diagnóstico específico para la FA.

  8. Distribución espacial del dengue basado en herramientas del Sistema de Información Geográfica, Valle de Aburrá, Colombia / Spatial distribution of dengue based on Geographic Information Systems tools, Aburra Valley

    Directory of Open Access Journals (Sweden)

    Libardo A. Londoño C

    2013-08-01

    Full Text Available Las enfermedades tropicales son infecciones provocadas por mosquitos y moscas que transmiten parásitos, bacterias o virus a individuos, una de ellas es el dengue, el cual ataca especialmente a personas en condiciones de pobreza y marginalidad, proliferando en lugares con saneamiento básico deficiente, lo cual ha aumentado significativamente el número de casos. Objetivo: en el presente artículo se usan los Sistemas de Información Geográfica (SIG para el modelamiento de patrones de distribución espacial de enfermedades tropicales. Se toma como caso de estudio los reportes del dengue mes a mes de los años 2008, 2009 y 2011 en el Valle de Aburrá en la jurisdicción de Medellín, Colombia. Metodología: se ubicaron espacialmente los casos de dengue notificados a la Secretaría de Salud de Medellín a través de las direcciones de las viviendas de los pacientes. Se ubicaron geoespacialmente utilizando el software ArcGis 10, y las herramientas de análisis espacial IDW y Slope para demostrar que el fenómeno del dengue cumple con el principio de autocorrelación espacial. Resultados y discusión: la enfermedad muestra patrones espaciales en el sector suroccidental de Medellín; Corregimiento de Altavista y en las Comunas de Belén y Guayabal; sin embargo, sería de gran interés estudiar este fenómeno con variables ambientales y poder tener más herramientas para la toma de decisiones en las actividades de prevención del dengue. - Tropical diseases are infections caused by mosquitoes and flies which transmit parasites, bacteria or viruses of people. One of these diseases is dengue, which particularly attacks those living in poor or marginalized conditions, proliferating in places lacking basic sanitation, which has significantly increased the number of cases. Objective: Geographic Information Systems (gis were used in this paper for the purpose of modeling the spatial distribution patterns of tropical diseases. Monthly reports on dengue from

  9. Dengue Hemorrhagic Fever: Epidemiology, Pathogenesis, and Its Transmission Risk Factors

    Directory of Open Access Journals (Sweden)

    Aryu Candra

    2010-12-01

    Full Text Available Dengue hemorrhagic fever is an infectious disease resulting spectrum of clinical manifestations that vary from the lightest, dengue fever, hemorrhagic fever and dengue fever are accompanied by shock or dengue shock syndrome. Its caused by dengue virus, transmitted by Aedes mosquitoes. The case is spread in the tropics, especially in Southeast Asia, Central America, America and the Caribbean, many causes of death in children 90% of them attacking children under 15 years old. Until now pathogenesis is unclear. There are two theories or hypotheses immuno-patogenesis DHF and DSS is still controversial which secondary infections (secondary heterologus infection and antibody-dependent enhancement. Risk factors for dengue transmission are rapid urban population growth, mobilization of the population because of improved transportation facilities and disrupted or weakened so that population control. Another risk factor is poverty which result in people not has the ability to provide a decent home and healthy, drinking water supply and proper waste disposal.

  10. Underrecognition of Dengue during 2013 Epidemic in Luanda, Angola.

    Science.gov (United States)

    Sharp, Tyler M; Moreira, Rosa; Soares, Maria José; Miguel da Costa, Lúis; Mann, Jennifer; DeLorey, Mark; Hunsperger, Elizabeth; Muñoz-Jordán, Jorge L; Colón, Candimar; Margolis, Harold S; de Caravalho, Adelaide; Tomashek, Kay M

    2015-08-01

    During the 2013 dengue epidemic in Luanda, Angola, 811 dengue rapid diagnostic test-positive cases were reported to the Ministry of Health. To better understand the magnitude of the epidemic and identify risk factors for dengue virus (DENV) infection, we conducted cluster surveys around households of case-patients and randomly selected households 6 weeks after the peak of the epidemic. Of 173 case cluster participants, 16 (9%) exhibited evidence of recent DENV infection. Of 247 random cluster participants, 25 (10%) had evidence of recent DENV infection. Of 13 recently infected participants who had a recent febrile illness, 7 (54%) had sought medical care, and 1 (14%) was hospitalized with symptoms consistent with severe dengue; however, none received a diagnosis of dengue. Behavior associated with protection from DENV infection included recent use of mosquito repellent or a bed net. These findings suggest that the 2013 dengue epidemic was larger than indicated by passive surveillance data.

  11. Dengue Haemorrhagic Encephalitis: Rare Case Report with Review of Literature.

    Science.gov (United States)

    Kutiyal, Aditya Singh; Malik, Chetanya; Hyanki, Gitika

    2017-07-01

    Dengue is an endemic arboviral infection prevalent especially in tropical countries including Southern and Southeast Asia. Central Nervous System (CNS) involvement in dengue infection is uncommon. Haemorrhagic encephalitis is a rare presentation in dengue. This is a case of a 58-year-old male who presented with fever, petechial rash and altered sensorium. Dengue serology IgM was reactive and MRI brain was suggestive of haemorrhagic encephalitis. Patient was managed in Intensive Care Unit (ICU) but eventually succumbed to his illness. We report this fatal outcome of a common viral infection with unusual neurological presentation to propose an association between dengue and neurotropism and the need to look at dengue infection beyond its classical features.

  12. A Case of Dengue Maculopathy with Spontaneous Recovery

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    Fiona Oi-jing Luk

    2013-06-01

    Full Text Available Purpose: To report a case of dengue maculopathy, which resolved spontaneously without treatment. Methods: A 25-year-old female patient with good past health was admitted to a general hospital in Hong Kong with fever of unknown origin after traveling to Indonesia. Based on the clinical features and a positive real-time polymerase chain reaction for dengue virus type 1, she was diagnosed with dengue fever. The patient developed dengue maculopathy mainly affecting the vision of her left eye. Abnormalities on a multifocal electroretinogram showed bilateral involvement. Results: As there is no proven treatment for dengue maculopathy, the patient opted for observation. Her vision returned to normal within 3 weeks. Conclusion: Dengue maculopathy can cause severe visual loss and may resolve without treatment.

  13. Gammagrafía renal en niños con primera infección febril del tracto urinario

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    María Caridad Duarte Pérez

    2012-12-01

    Full Text Available Introducción: la infección del tracto urinario es una de las infecciones bacterianas más frecuentes en la infancia. Objetivos: conocer las alteraciones renales en la fase aguda de la primera infección febril del tracto urinario, y relacionarlas con las variables estudiadas. Métodos: se estudiaron 211 niños con diagnóstico microbiológico de primera infección febril del tracto urinario, a los cuales se les realizó gammagrafía renal con Tc-DMSA en la fase aguda de la infección. Los resultados de la gammagrafía se correlacionaron con la duración e intensidad de la fiebre antes del diagnóstico, los reactantes de la fase aguda (hemograma, eritrosedimentación y proteína C reactiva y los resultados de los estudios imaginológicos (ultrasonido renal y uretrocistografía miccional. Resultados: predominó el sexo femenino y el 82,4 % de los pacientes fueron menores de un año. El 54 % de los pacientes presentaron alteraciones gammagráficas, y el patrón de hipocaptación del radiofármaco fue el hallazgo que predominó en el 70 % de ellos. Se encontró asociación significativa al relacionar la duración e intensidad de la fiebre con las alteraciones renales. De los parámetros de laboratorio, la leucocitosis superior a 15 000, la eritrosedimentación acelerada y la proteína C reactiva elevada, tuvieron significación estadística con las alteraciones renales, y los hallazgos radiológicos detectados por el ultrasonido renal y uretrocistografía miccional se correlacionaron estadísticamente con la afectación renal detectada con la gammagrafía. Conclusiones: un porcentaje elevado de los pacientes presentó extensión de la infección al parénquima renal, y las variables clínicas, de laboratorio e imaginológicas estudiadas fueron parámetros orientadores de daño renal.

  14. Clinical score to differentiate scrub typhus and dengue: A tool to differentiate scrub typhus and dengue

    Directory of Open Access Journals (Sweden)

    Shubhanker Mitra

    2017-01-01

    Full Text Available Background: Dengue and scrub typhus share similar clinical and epidemiological features, and are difficult to differentiate at initial presentation. Many places are endemic to both these infections where they comprise the majority of acute undifferentiated febrile illnesses. Materials and Methods: We aimed to develop a score that can differentiate scrub typhus from dengue. In this cross-sectional study, 188 cases of scrub typhus and 201 cases of dengue infection who presented to the emergency department or medicine outpatient clinic from September 2012 to April 2013 were included. Univariate followed by multivariate logistic regression analysis was performed to identify clinical features and laboratory results that were significantly different between the two groups. Each variable was assigned scores based on the strength of association and receiver operating characteristics area under the curve (ROC-AUC was generated and compared. Six scoring models were explored to ascertain the model with the best fit. Results: Model 2 was developed using the following six variables: oxygen saturation (>90%, ≤90%, total white blood cell count (7000 cells/cumm, hemoglobin (≤14 and >14 g/dL, total bilirubin (200 and ≥200 IU/dL, and altered sensorium (present or absent. Each variable was assigned scores based on its strength of association. The AUC-ROC curve (95% confidence interval for model 2 was 0.84 (0.79–0.89. At the cut off score of 13, the sensitivity and specificity were 85% and 77% respectively, with a higher score favoring dengue. Conclusion: In areas of high burden of ST and dengue, model 2 (the “clinical score to differentiate scrub typhus and dengue fever” is a simple and rapid clinical scoring system that may be used to differentiate scrub typhus and dengue at initial presentation.

  15. Clinical Score to Differentiate Scrub Typhus and Dengue: A Tool to Differentiate Scrub Typhus and Dengue.

    Science.gov (United States)

    Mitra, Shubhanker; Gautam, Ira; Jambugulam, Mohan; Abhilash, Kundavaram Paul Prabhakar; Jayaseeelan, Vishalakshi

    2017-01-01

    Dengue and scrub typhus share similar clinical and epidemiological features, and are difficult to differentiate at initial presentation. Many places are endemic to both these infections where they comprise the majority of acute undifferentiated febrile illnesses. We aimed to develop a score that can differentiate scrub typhus from dengue. In this cross-sectional study, 188 cases of scrub typhus and 201 cases of dengue infection who presented to the emergency department or medicine outpatient clinic from September 2012 to April 2013 were included. Univariate followed by multivariate logistic regression analysis was performed to identify clinical features and laboratory results that were significantly different between the two groups. Each variable was assigned scores based on the strength of association and receiver operating characteristics area under the curve (ROC-AUC) was generated and compared. Six scoring models were explored to ascertain the model with the best fit. Model 2 was developed using the following six variables: oxygen saturation (>90%, ≤90%), total white blood cell count (7000 cells/cumm), hemoglobin (≤14 and >14 g/dL), total bilirubin (200 and ≥200 IU/dL), and altered sensorium (present or absent). Each variable was assigned scores based on its strength of association. The AUC-ROC curve (95% confidence interval) for model 2 was 0.84 (0.79-0.89). At the cut off score of 13, the sensitivity and specificity were 85% and 77% respectively, with a higher score favoring dengue. In areas of high burden of ST and dengue, model 2 (the "clinical score to differentiate scrub typhus and dengue fever") is a simple and rapid clinical scoring system that may be used to differentiate scrub typhus and dengue at initial presentation.

  16. Evaluation of Internet-based dengue query data: Google Dengue Trends.

    Directory of Open Access Journals (Sweden)

    Rebecca Tave Gluskin

    2014-02-01

    Full Text Available Dengue is a common and growing problem worldwide, with an estimated 70-140 million cases per year. Traditional, healthcare-based, government-implemented dengue surveillance is resource intensive and slow. As global Internet use has increased, novel, Internet-based disease monitoring tools have emerged. Google Dengue Trends (GDT uses near real-time search query data to create an index of dengue incidence that is a linear proxy for traditional surveillance. Studies have shown that GDT correlates highly with dengue incidence in multiple countries on a large spatial scale. This study addresses the heterogeneity of GDT at smaller spatial scales, assessing its accuracy at the state-level in Mexico and identifying factors that are associated with its accuracy. We used Pearson correlation to estimate the association between GDT and traditional dengue surveillance data for Mexico at the national level and for 17 Mexican states. Nationally, GDT captured approximately 83% of the variability in reported cases over the 9 study years. The correlation between GDT and reported cases varied from state to state, capturing anywhere from 1% of the variability in Baja California to 88% in Chiapas, with higher accuracy in states with higher dengue average annual incidence. A model including annual average maximum temperature, precipitation, and their interaction accounted for 81% of the variability in GDT accuracy between states. This climate model was the best indicator of GDT accuracy, suggesting that GDT works best in areas with intense transmission, particularly where local climate is well suited for transmission. Internet accessibility (average ∼ 36% did not appear to affect GDT accuracy. While GDT seems to be a less robust indicator of local transmission in areas of low incidence and unfavorable climate, it may indicate cases among travelers in those areas. Identifying the strengths and limitations of novel surveillance is critical for these types of data to

  17. Dengue surveillance in Veterans Affairs healthcare facilities, 2007-2010.

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    Patricia L Schirmer

    Full Text Available BACKGROUND: Although dengue is endemic in Puerto Rico (PR, 2007 and 2010 were recognized as epidemic years. In the continental United States (US, outside of the Texas-Mexico border, there had not been a dengue outbreak since 1946 until dengue re-emerged in Key West, Florida (FL, in 2009-2010. The objective of this study was to use electronic and manual surveillance systems to identify dengue cases in Veterans Affairs (VA healthcare facilities and then to clinically compare dengue cases in Veterans presenting for care in PR and in FL. METHODOLOGY: Outpatient encounters from 1/2007-12/2010 and inpatient admissions (only available from 10/2009-12/2010 with dengue diagnostic codes at all VA facilities were identified using VA's Electronic Surveillance System for Early Notification of Community-based Epidemics (ESSENCE. Additional case sources included VA data from Centers for Disease Control and Prevention BioSense and VA infection preventionists. Case reviews were performed. Categorical data was compared using Mantel-Haenszel or Fisher Exact tests and continuous variables using t-tests. Dengue case residence was mapped. FINDINGS: Two hundred eighty-eight and 21 PR and FL dengue cases respectively were identified. Of 21 FL cases, 12 were exposed in Key West and 9 were imported. During epidemic years, FL cases had significantly increased dengue testing and intensive care admissions, but lower hospitalization rates and headache or eye pain symptoms compared to PR cases. There were no significant differences in clinical symptoms, laboratory abnormalities or outcomes between epidemic and non-epidemic year cases in FL and PR. Confirmed/probable cases were significantly more likely to be hospitalized and have thrombocytopenia or leukopenia compared to suspected cases. CONCLUSIONS: Dengue re-introduction in the continental US warrants increased dengue surveillance and education in VA. Throughout VA, under-testing of suspected cases highlights the need to

  18. Dengue Contingency Planning: From Research to Policy and Practice

    Science.gov (United States)

    Runge-Ranzinger, Silvia; Kroeger, Axel; Olliaro, Piero; McCall, Philip J.; Sánchez Tejeda, Gustavo; Lloyd, Linda S.; Hakim, Lokman; Bowman, Leigh R.; Horstick, Olaf; Coelho, Giovanini

    2016-01-01

    Background Dengue is an increasingly incident disease across many parts of the world. In response, an evidence-based handbook to translate research into policy and practice was developed. This handbook facilitates contingency planning as well as the development and use of early warning and response systems for dengue fever epidemics, by identifying decision-making processes that contribute to the success or failure of dengue surveillance, as well as triggers that initiate effective responses to incipient outbreaks. Methodology/Principal findings Available evidence was evaluated using a step-wise process that included systematic literature reviews, policymaker and stakeholder interviews, a study to assess dengue contingency planning and outbreak management in 10 countries, and a retrospective logistic regression analysis to identify alarm signals for an outbreak warning system using datasets from five dengue endemic countries. Best practices for managing a dengue outbreak are provided for key elements of a dengue contingency plan including timely contingency planning, the importance of a detailed, context-specific dengue contingency plan that clearly distinguishes between routine and outbreak interventions, surveillance systems for outbreak preparedness, outbreak definitions, alert algorithms, managerial capacity, vector control capacity, and clinical management of large caseloads. Additionally, a computer-assisted early warning system, which enables countries to identify and respond to context-specific variables that predict forthcoming dengue outbreaks, has been developed. Conclusions/Significance Most countries do not have comprehensive, detailed contingency plans for dengue outbreaks. Countries tend to rely on intensified vector control as their outbreak response, with minimal focus on integrated management of clinical care, epidemiological, laboratory and vector surveillance, and risk communication. The Technical Handbook for Surveillance, Dengue Outbreak

  19. Dengue, zika, chikungunya and the development of vaccines

    OpenAIRE

    Isabel N. Kantor

    2018-01-01

    Dengue (DENV), zika (ZIKV) and chikungunya (CHIKV), three arbovirosis transmitted by Aedes mosquitoes, have spread in recent decades in humid tropical and subtropical zones. Dengue is epidemic in subtropical areas of Argentina. DENV infection confers lasting immunity against the infecting serotype but increases the risk of serious disease upon reinfection by any of the other three. The recombinant tetravalent vaccine Dengvaxia® prevents severe dengue and hospitalization in seropositive subjec...

  20. VAKSIN DENGUE DAN PERKEMBANGANNYA SAAT INI DAN DI MASA MENDATANG

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    Triwibowo Ambar Garjito

    2012-09-01

    Full Text Available Dengue virus merupakan salah satu virus anggota dari famili Flaviviridae yang sejak tahun 1956 telah dikenal dapat menimbulkan demam dengue maupun demam berdarah dengue (DBD. Penyakit yang ditularkan oleh nyamuk Aedes aegypti ini diperkirakan telah menjangkiti pada selatar 50-100 juta manusia dengan 500.000 kasus di antaranya dalam manifestasi yang ganas yang dikenal sebagai dengue haemorrhagic fever dan dengue shock syndrome dan 25.000 di antaranya berakibat fatal (meninggal. Saat ini pengembangan vaksin merupakan salah satu solusi yang diharapkan dapat menekan penyebaran penyakit tersebut. E (envelope merupakan salah satu bagian dari protein struktural virus yang sangat penting dalam pengembangan vaksin, yaitu sebagai badan yang memproduksi antibodi netralisasi untuk protein. Non-struktural protein l juga telah diketahui sebagai salah satu komponen penting dalam pengembangan vaksin oleh karena kemampuannya untuk dapat diekspresi pada permukaan sel yang diinfeksi yang dapat menjadi target untuk immune cytolisis. Ada dua pendekatan yang digunakan dalam memproduksi suatu vaksin dengue, yaitu: a. Vaksin hidup yang telah dilemahkan (live attenuated vaccine: b. Vaksin hasil rekayasa (engineered vaccine. Penelitian terhadap vaksin DENV baik rekombinan maupun non-rekombinan yang didasarkan pada uji virus telah dilakukan secara terus-menerus baik pada monyet dan manusia. Sampai saat ini telah dikembangkan sejumlah kandidat vaksin DENV yang berdasar pada tetravalent virus dengue, yaitu a. vaksin konvensional, b. vaksin dengue rekombinan berdasar pada flavivirus, c. vaksin intertypic chimeric, d. vaksin chimerivac, e. vaksin dengue rekombinan menggunakan vector non-ftavivirus dan f. vector adenovirus. Namun demikian, sampai sekarang belum ada vaksin yang siap digunakan untuk menangkal infeksi ke empat serotype virus dengue, sehingga masih diharapkan untuk pengembangan virus lebih lanjut.   Kata kunci: Aedes aegypti, dengue virus, vaksin dengue.

  1. Dengue fever as a cause of hemophagocytic lymphohistiocytosis

    OpenAIRE

    Hein, Noely; Bergara, Gabriel Heiser; Moura, Nathalie Bianchini Vieira; Cardoso, D?bora Morais; Hirose, Maki; Ferronato, Angela Esp?sito; Pastorino, Ant?nio Carlos; Lo, Denise Swei; Gilio, Alfredo Elias

    2015-01-01

    Dengue is endemic in more than 100 countries in Southeast Asia, the Americas, the western Pacific, Africa and the eastern Mediterranean regions. The virus is transmitted by Aedes mosquitoes. Dengue disease is the most prevalent arthropod-borne viral disease in humans and is a global and national public health concern in several countries. A seasonal pattern of dengue disease is consistently observed. The highest incidences usually correspond to the period of highest rainfall and humidity, pro...

  2. Imported dengue virus serotype 1 from Madeira to Finland 2012.

    Science.gov (United States)

    Huhtamo, E; Korhonen, Em; Vapalahti, O

    2013-02-21

    Imported dengue cases originating from the Madeiran outbreak are increasingly reported. In 2012 five Finnish travellers returning from Madeira were diagnosed with dengue fever. Viral sequence data was obtained from two patients. The partial C-preM sequences (399 and 396 bp respectively) were found similar to that of an autochthonous case from Madeira. The partial E-gene sequence (933 bp) which was identical among the two patients grouped phylogenetically with South American strains of dengue virus serotype 1.

  3. Encefalitis por virus San Luis en la Ciudad de Buenos Aires durante el brote de dengue 2009

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    Horacio López

    2011-06-01

    Full Text Available Se presenta un paciente de 80 años de edad, residente en la Ciudad de Buenos Aires, con diagnóstico serológico para el virus de la encefalitis de San Luis (SLE durante el brote de dengue ocurrido entre enero y mayo de 2009. Presentaba leucemia linfoide crónica en tratamiento con clorambucilo, cáncer de próstata tratado con hormonoterapia y radioterapia, e imágenes óseas compatibles con metástasis. El estudio del líquido cefalorraquídeo demostró pleocitosis con predominio de mononucleares y proteinorraquia elevada. El resultado de los cultivos para bacterias, hongos y micobacterias, así como el PCR en LCR para herpes virus, HSV, CMV y EBV, fue negativo. Se detectaron anticuerpos IgM para virus SLE tanto en LCR como en muestra de suero, con seroconversión IgG por neutralización en cultivos celulares y resultados negativos para los demás Flavivirus con circulación en Argentina. Se revisan evidencias sobre la presencia de virus de San Luis en nuestro país, y se señala la importancia de la confirmación diagnóstica y el estudio de otros Flavivirus en casos sospechosos de dengue con presentación grave o atípica. Este trabajo remarca la necesidad de fortalecer tanto la vigilancia epidemiológica del virus SLE, como el control vectorial para prevenir las diferentes infecciones transmitidas por mosquitos y conocer su efecto en Salud Pública en la Argentina.

  4. Relative Contribution of Dengue IgG Antibodies Acquired during Gestation or Breastfeeding in Mediating Dengue Disease Enhancement and Protection in Type I Interferon Receptor-Deficient Mice.

    Science.gov (United States)

    Lee, Pei Xuan; Ong, Li Ching; Libau, Eshele Anak; Alonso, Sylvie

    2016-06-01

    Dengue virus (DENV) causes a spectrum of diseases ranging from self-limiting dengue fever to severe conditions such as haemorrhagic fever and dengue shock syndrome. Antibody-dependent enhancement (ADE) is thought to explain the occurrence of severe dengue whereby pre-existing binding but non-neutralising antibodies enhance DENV infection. The ADE phenomenon is supported by epidemiological findings that infants that born to dengue immune mothers are at greater risk to develop severe dengue upon primary infection. The role of maternally acquired dengue-specific antibodies in disease enhancement was recently recapitulated in a mouse model where mice born to DENV1-immune mothers experienced enhanced disease severity upon DENV2 infection. Here, this study investigates the relative contribution of maternal dengue-specific antibodies acquired during gestation and breastfeeding in dengue disease. Using a surrogate breastfeeding mother experimental approach, we showed that majority of the maternal dengue-specific antibodies were acquired during breastfeeding and conferred an extended enhancement window. On the other hand, in the context of homologous infection, breastfeeding conferred protection. Furthermore, measurement of dengue-specific antibody titres over time in mice born to dengue immune mothers revealed a biphasic pattern of antibody decay as reported in humans. Our work provides evidence of the potential contribution of breast milk-acquired dengue-specific IgG antibodies in enhancement and protection against dengue. Should such contribution be established in humans as well, it may have important implications for the development of guidelines to dengue-immune breastfeeding mothers.

  5. Análisis costo-beneficio del control de vectores en la transmisión potencial de dengue Cost-benefit analysis of vector control in areas of potential dengue transmission

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    Pablo Wenceslao Orellano

    2008-08-01

    Full Text Available OBJETIVOS: Evaluar el costo-beneficio de una intervención de control de mosquitos adultos con fumigación, junto con actividades de control de formas inmaduras de Aedes aegypti, para evitar la transmisión en una situación de alto riesgo. MÉTODOS: Se realizó un análisis de costo-beneficio desde una perspectiva social. Se comparó una intervención para el control de mosquitos adultos y formas inmaduras contra una hipótesis de no-intervención, de enero a abril de 2007, en la ciudad de Clorinda, Argentina. Se consideraron los costos directos y los beneficios indirectos e intangibles, estandarizados a dólares internacionales (I$ utilizando la paridad de poder adquisitivo. Se asumió una incidencia de 50 casos de dengue por 1 000 habitantes en la hipótesis de no-intervención. RESULTADOS: De enero a abril de 2007 se presentaron 176 casos de dengue en Clorinda, pero sólo cinco fueron autóctonos. El valor presente neto fue de I$ 196 879 en la estrategia de aplicación de control, mientras que en la de no aplicación se calculó en I$ -106 724, lo que significaría un ahorro de I$ 303 602 (I$ 6,46 por habitante con la intervención. El análisis de sensibilidad evidenció que, con más de 1 363 casos de dengue (incidencia total de 29 por 1 000 habitantes y un caso de dengue hemorrágico, la intervención es costo-benéfica. CONCLUSIONES: Los resultados sugieren que el control vectorial, incluyendo la fumigación para mosquitos adultos, debe evaluarse en situaciones de alto riesgo de transmisión como una alternativa costo-benéfica en países no endémicos.OBJECTIVES: To evaluate the cost-benefit of an intervention utilizing fumigation against adult mosquitoes along with actions to control immature Aedes aegypti to prevent transmission in a high-risk area. METHODS: A cost-benefit analysis was performed from the social perspective. A program to control both adult mosquitoes and immature forms was compared to a non-intervention hypothesis

  6. Dengue hemorrhagic fever and acute hepatitis: a case report

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    Maria Paula Gomes Mourão

    Full Text Available Dengue fever is the world's most important viral hemorrhagic fever disease, the most geographically wide-spread of the arthropod-born viruses, and it causes a wide clinical spectrum of disease. We report a case of dengue hemorrhagic fever complicated by acute hepatitis. The initial picture of classical dengue fever was followed by painful liver enlargement, vomiting, hematemesis, epistaxis and diarrhea. Severe liver injury was detected by laboratory investigation, according to a syndromic surveillance protocol, expressed in a self-limiting pattern and the patient had a complete recovery. The serological tests for hepatitis and yellow fever viruses were negative. MAC-ELISA for dengue was positive.

  7. Dengue hemorrhagic fever and acute hepatitis: a case report.

    Science.gov (United States)

    Mourão, Maria Paula Gomes; Lacerda, Marcus Vinícius Guimarães de; Bastos, Michele de Souza; Albuquerque, Bernardino Cláudio de; Alecrim, Wilson Duarte

    2004-12-01

    Dengue fever is the world's most important viral hemorrhagic fever disease, the most geographically wide-spread of the arthropod-born viruses, and it causes a wide clinical spectrum of disease. We report a case of dengue hemorrhagic fever complicated by acute hepatitis. The initial picture of classical dengue fever was followed by painful liver enlargement, vomiting, hematemesis, epistaxis and diarrhea. Severe liver injury was detected by laboratory investigation, according to a syndromic surveillance protocol, expressed in a self-limiting pattern and the patient had a complete recovery. The serological tests for hepatitis and yellow fever viruses were negative. MAC-ELISA for dengue was positive.

  8. Research on Climate and Dengue in Malaysia: A Systematic Review

    OpenAIRE

    Hii, Yien Ling; Zaki, Rafdzah Ahmad; Aghamohammadi, Nasrin; Rockl?v, Joacim

    2016-01-01

    Background & Objectives Dengue is a climate-sensitive infectious disease. Climate-based dengue early warning may be a simple, low-cost, and effective tool for enhancing surveillance and control. Scientific studies on climate and dengue in local context form the basis for advancing the development of a climate-based early warning system. This study aims to review the current status of scientific studies in climate and dengue and the prospect or challenges of such research on a climate-based de...

  9. Investigational drugs in early development for treating dengue infection.

    Science.gov (United States)

    Beesetti, Hemalatha; Khanna, Navin; Swaminathan, Sathyamangalam

    2016-09-01

    Dengue has emerged as the most significant arboviral disease of the current century. A drug for dengue is an urgent unmet need. As conventional drug discovery efforts have not produced any promising clinical candidates, there is a shift toward re-positioning pre-existing drugs for dengue to fast-track dengue drug development. This article provides an update on the current status of recently completed and ongoing dengue drug trials. All dengue drug trials described in this article were identified from a list of >230 trials that were returned upon searching the World Health Organization's International Clinical Trials Registry Platform web portal using the search term 'dengue' on December 31(st), 2015. None of the handful of drugs tested so far has yielded encouraging results. Early trial experience has served to emphasize the challenge of drug testing in the short therapeutic time window available, the need for tools to predict 'high-risk' patients early on and the limitations of the existing pre-clinical model systems. Significant investment of efforts and resources is a must before the availability of a safe, effective and inexpensive dengue drug becomes a reality. Currently, supportive fluid therapy remains the only option available for dengue treatment.

  10. Prevention and Control Strategies to Counter Dengue Virus Infection.

    Science.gov (United States)

    Rather, Irfan A; Parray, Hilal A; Lone, Jameel B; Paek, Woon K; Lim, Jeongheui; Bajpai, Vivek K; Park, Yong-Ha

    2017-01-01

    Dengue is currently the highest and rapidly spreading vector-borne viral disease, which can lead to mortality in its severe form. The globally endemic dengue poses as a public health and economic challenge that has been attempted to suppress though application of various prevention and control techniques. Therefore, broad spectrum techniques, that are efficient, cost-effective, and environmentally sustainable, are proposed and practiced in dengue-endemic regions. The development of vaccines and immunotherapies have introduced a new dimension for effective dengue control and prevention. Thus, the present study focuses on the preventive and control strategies that are currently employed to counter dengue. While traditional control strategies bring temporary sustainability alone, implementation of novel biotechnological interventions, such as sterile insect technique, paratransgenesis, and production of genetically modified vectors, has improved the efficacy of the traditional strategies. Although a large-scale vector control strategy can be limited, innovative vaccine candidates have provided evidence for promising dengue prevention measures. The use of tetravalent dengue vaccine (CYD-TDV) has been the most effective so far in treating dengue infections. Nonetheless, challenges and limitation hinder the progress of developing integrated intervention methods and vaccines; while the improvement in the latest techniques and vaccine formulation continues, one can hope for a future without the threat of dengue virus.

  11. Prevention and Control Strategies to Counter Dengue Virus Infection

    Directory of Open Access Journals (Sweden)

    Irfan A. Rather

    2017-07-01

    Full Text Available Dengue is currently the highest and rapidly spreading vector-borne viral disease, which can lead to mortality in its severe form. The globally endemic dengue poses as a public health and economic challenge that has been attempted to suppress though application of various prevention and control techniques. Therefore, broad spectrum techniques, that are efficient, cost-effective, and environmentally sustainable, are proposed and practiced in dengue-endemic regions. The development of vaccines and immunotherapies have introduced a new dimension for effective dengue control and prevention. Thus, the present study focuses on the preventive and control strategies that are currently employed to counter dengue. While traditional control strategies bring temporary sustainability alone, implementation of novel biotechnological interventions, such as sterile insect technique, paratransgenesis, and production of genetically modified vectors, has improved the efficacy of the traditional strategies. Although a large-scale vector control strategy can be limited, innovative vaccine candidates have provided evidence for promising dengue prevention measures. The use of tetravalent dengue vaccine (CYD-TDV has been the most effective so far in treating dengue infections. Nonetheless, challenges and limitation hinder the progress of developing integrated intervention methods and vaccines; while the improvement in the latest techniques and vaccine formulation continues, one can hope for a future without the threat of dengue virus.

  12. The 2012 dengue outbreak in Madeira: exploring the origins.

    Science.gov (United States)

    Wilder-Smith, A; Quam, M; Sessions, O; Rocklov, J; Liu-Helmersson, J; Franco, L; Khan, K

    2014-02-27

    In 2012, Madeira reported its first major outbreak of dengue. To identify the origin of the imported dengue virus, we investigated the interconnectivity via air travel between dengue-endemic countries and Madeira, and compared available sequences against GenBank. There were 22,948 air travellers to Madeira in 2012, originating from twenty-nine dengue-endemic countries; 89.6% of these international travellers originated from Venezuela and Brazil. We developed an importation index that takes into account both travel volume and the extent of dengue incidence in the country of origin. Venezuela and Brazil had by far the highest importation indices compared with all other dengue-endemic countries. The importation index for Venezuela was twice as high as that for Brazil. When taking into account seasonality in the months preceding the onset of the Madeira outbreak, this index was even seven times higher for Venezuela than for Brazil during this time. Dengue sequencing shows that the virus responsible for the Madeira outbreak was most closely related to viruses circulating in Venezuela, Brazil and Columbia. Applying the importation index, Venezuela was identified as the most likely origin of importation of dengue virus via travellers to Madeira. We propose that the importation index is a new additional tool that can help to identify and anticipate the most probable country of origin for importation of dengue into currently non-endemic countries.

  13. Dengue fever in the San Juan Bay Estuary: Evaluating the ...

    Science.gov (United States)

    Dengue is transmitted by Aedes aegypti, a species that thrives in cities. Here we ask which elements within the urban environment could be managed to reduce the potential for Dengue occurrence. In particular, we study the potential of wetlands in the SJBE to buffer from vector proliferation. Wetlands provide ecosystem services such as heat and water hazard mitigation, water purification and habitat for a diversity of species, all of which are factors that have been shown to affect Dengue vectors. As such, we hypothesize that within coastal neighborhoods in the SJBE wetlands, ecosystem services lead to lower Dengue occurrence. We test this hypothesis using Dengue data from 2010-2013, which includes the largest epidemic in PR history. Our analytical model includes relevant socio-economic factors and environmental controls that may also affect Dengue dynamics. Results indicated a negative effect of neighborhood mangrove cover and a positive effect of percent flood area on Dengue prevalence. Moreover, heat hazards were positively correlated with dengue prevalence and negatively correlated with neighborhood mangrove cover. Dengue prevalence did not correlate with herbaceous wetlands, or with the ecosystem services of water quality or vertebrate species richness. Mosquito borne diseases are an increasingly important health concern, which pose great challenges for safe and sustainable control and eradication. This reality calls for management approaches that consider m

  14. A model of immunomodulatory for dengue infection mm

    Science.gov (United States)

    Zulfa, Annisa; Handayani, Dewi; Nuraini, Nuning

    2018-03-01

    An immunomodulatory model for dengue infection is constructed in this paper. This study focuses on T-cell compartments and B cells that are immune cells involved in the dengue infection process. Dengue virus-infected monocyte cells release interferons to signal T-cells to activate B-cells and produce antibodies. Immunomodulator acts as a treatment control and aims to increase the numbers of antibodies so it is expected to reduce the number of infected monocyte cells by dengue virus. Numerical simulation shows that the greater the rate of f (t) the immune cells will be stimulated to suppress the number of infected cells.

  15. Neutralización por reducción en placas como método específico para el Diagnóstico Serológico de Fiebre Amarilla

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    Maribel Acuña B

    2001-07-01

    Full Text Available Objetivos: Estudiar la capacidad neutralizante de muestras séricas humanas para ser empleada como prueba de confirmación frente a otras técnicas y evaluar la relación de neutralización en diferentes poblaciones para cepas de FA: 287-78 (nativa y 17D (referencial. Materiales y métodos: Se empleó la cepa 17D para la estandarización de la prueba en células VERO utilizando dos métodos (sólido y semi-líquido; además, se seleccionaron muestras séricas humanas en base al antecedente vacunal (presente o ausente, a la procedencia (endémica y no endémica y la positividad a virus del dengue, las cuáles fueron evaluadas por ELISA. Las poblaciones seleccionadas se enfrentaron por la prueba estandarizada (PRNT frente a las cepas de FA: 17D (cepa vacunal derivada del prototipo Asibi y 287-78 (primer aislamiento de FA del Instituto Nacional de Salud del Perú. Resultados: Se obtuvieron buenos resultados con el método semi-líquido, siendo el séptimo día el óptimo de coloración de las placas. De los cuatro grupos seleccionados, tres fueron positivos por ELISA y los resultados por PRNT fueron para la suspensión 17D, 29 negativos y 67 positivos con títulos entre 1:10 y 1:2560; y para la cepa 287-78, 17 negativos y 79 positivos con títulos entre 1:10 y 1:2560. Conclusiones: La técnica semi-líquida con tiempo de coloración al séptimo día ofrece óptimos resultados en plaqueo y neutralización. Además, el ELISA resultó ser menos específico frente al PRNT y se encontró variación en relación a títulos y capacidad neutralizante en algunos sueros para ambas cepas.

  16. MORBIMORTALIDADE DA DENGUE EM IDOSOS NO BRASIL - DENGUE MORBIDITY AND MORTALITY IN ELDERLY IN BRAZIL

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    Annah Rachel Graciano

    2017-07-01

    Full Text Available Objective: To determine the prevalence and specific dengue coefficients of mortality in Brazil in the elderly population correlating the rates by male and female. Methods: Analytical ecological study with temporal trend of design. It was used as data sources Sistema de Informação Hospitalar, Sistema de Informação de Mortalidade and Instituto Brasileiro de Geografia e Estatística. The population corresponded to the elderly aged between 60 years to 100 attended at Brazilian public health system whom were diagnosed with dengue between 2008 and 2015. Results: The prevalence rates did not change in the general population between the years 2008 and 2015. There was a significant increase in the number of deaths from dengue. In the elderly group, the prevalence increased substantially, and the specific mortality analysis in this group showed higher values than the mortality of the general population affected by dengue. Conclusions: It is very important to underline studies on the involvement of dengue in elderly groups for the development of public politics and the creation of specific protocols for the diagnosis and treatment in that age group, considering the lack of scientific evidence to entail proper conduct in handling such patients

  17. Clinical profile and warning sign finding in children with severe dengue and non-severe dengue

    Science.gov (United States)

    Adam, A. S.; Pasaribu, S.; Wijaya, H.; Pasaribu, A. P.

    2018-03-01

    Dengue fever is one of the most important emerging vector-borne viral diseases. Approximately 500,000 out of 100 million cases develop to severe dengue infection. Patient with severe dengue (SD) can be predicted by clinical profile, laboratory and warning sign which could be saved by early interventions.This was a retrospective descriptive-analytic study to investigate clinical manifestations, laboratory and warning signs ofchildren with dengue infection in Haji Adam Malik hospital during January 2014–May 2016. Through medical records, we had selected 140 cases which fulfilled research criteria.Cases were classified as SD (n=28) and NSD (n=112). Most common clinical manifestations for NSD were abdominal pain (39.3%), myalgia (39.3%), headache (37.1%), mucosal bleeding (36.4%) while for SD were shock (15.7%), mucosal bleeding (15.7%), clinical fluid accumulation (15%), shortness of breath (14.3%). SGPT >1000IU/L (5 cases), SGOT >1000IU/L (9 cases), PT (10 cases) and aPTT (16 cases) were abnormal in SD. Severe dengue was frequently found in the range of white cell count 1000-4000/L and platelet count 20,000-50,000mm/uL. Clinical manifestations, warning sign, and laboratoryfinding, were different between SD and NSD.

  18. Prevalencia de anticuerpos neutralizantes contra los serotipos del virus dengue en universitarios de Tabasco, México Prevalence of neutralizing antibodies to dengue virus serotypes in university students from Tabasco, Mexico

    Directory of Open Access Journals (Sweden)

    Gilma Guadalupe Sánchez-Burgos

    2008-10-01

    Full Text Available OBJETIVO: Determinar la seroprevalencia de anticuerpos neutralizantes de los serotipos del virus dengue en estudiantes universitarios de Tabasco, México, durante los meses de septiembre a noviembre del año 2005. MATERIAL Y MÉTODOS: Se determinó la presencia de IgG contra el virus en el suero de estudiantes que acudieron al centro clínico de la universidad; en los sueros positivos se determinaron los anticuerpos neutralizantes mediante el ensayo de reducción de placa lítica. RESULTADOS: La prevalencia de IgG contra el dengue fue de 9.1%; de esta proporción, los anticuerpos neutralizantes fueron DENV-1 (20%, DENV-2 (100%, DENV-3 (4% y DENV-4 (68%. CONCLUSIONES: Este estudio muestra que el serotipo transmitido con mayor frecuencia en el estado de Tabasco es el DENV-2, aunque no ha sido el aislado con más frecuencia. La elevada prevalencia de anticuerpos neutralizantes contra el DENV-4, al parecer de reacción cruzada, podría explicar la baja circulación de este serotipo en Tabasco.OBJECTIVE: Determine the seroprevalence of neutralizing antibodies to dengue virus in students from the state university of Tabasco, Mexico. MATERIAL AND METHODS: A transversal study was conducted of serum collected from students between September and November, 2005. The sera were screened for anti-dengue IgG and those that had evidence of dengue antibodies were analyzed by a plaque reduction neutralization test. RESULTS: Prevalence of anti-dengue IgG was 9.1%. The frequency of neutralizing antibodies was 100% for DENV-2, 68% for DENV-4, 20% for DENV-1, and 4 % for DENV-3. CONCLUSIONS: We found that in this population, DENV-2 circulates more than DENV-3 despite the fact that DENV-3 is more frequently isolated. Unexpectedly, neutralizing antibodies against DENV-4 were frequently found even though this serotype is almost extinct; thus, it is probable that cross-immunity could suppress DEN-4 transmission, as has been suggested.

  19. Factors affecting dengue prevention practices: nationwide survey of the Malaysian public.

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    Li Ping Wong

    Full Text Available Efforts to stamp dengue in many dengue endemic countries has met little success. There is a need to re-examine and understand how the public at large view the dengue prevention efforts. This study aimed to examine the demographic factors, theoretical constructs of the Health Belief Model and knowledge about dengue and how these influence the practice of dengue prevention.A national telephone survey was carried out with 2,512 individuals of the Malaysian public aged 18-60 years.The majority (73% of the Malaysian public had a total dengue prevention score of 51-100 (of a possible score of 1-100. Multivariate analysis suggests significant correlates of higher dengue prevention practices with demographic background, perception of susceptibility to dengue, perceived density of mosquitoes in the neighbourhood and knowledge about dengue. Households of lower income of which the majority (40.7% were from the rural areas, were associated with the highest odds [OR = 1.33; 95%CI = 1.09-1.67; p = 0.004] of dengue prevention. Dengue prevention practices were also less likely to be undertaken in neighbourhoods where the responders perceived there is no and/or low density of mosquitoes. Dengue prevention practices are also less likely to be practiced by skilled workers [OR = 0.78; 95%CI = 0.63-0.95; p = 0.029] compared to those unemployed. Higher perceived susceptibility to dengue was associated with higher dengue prevention practices and participants with higher dengue knowledge were found to have a higher level of involvement in dengue prevention practices.Results from the study suggest that in formulating approaches to contain dengue, strategies should be developed to cultivate dengue prevention practices among urban population and target areas with low density of mosquitoes where public perceived a less likely chance of getting dengue. Dengue prevention campaigns should focus on messages highlighting the risk of contracting dengue and education to increase

  20. Caracterización clínica y epidemiológica de los casos de dengue: experiencia del Hospital General de Culiacán, Sinaloa, México Clinical and epidemiologic characteristics of dengue cases: the experience of a general hospital in Culiacan, Sinaloa, Mexico

    Directory of Open Access Journals (Sweden)

    María Guadalupe Ramírez-Zepeda

    2009-01-01

    Full Text Available OBJETIVO: Documentar las características clínicas y epidemiológicas de los pacientes con dengue atendidos en un hospital de Culiacán, Sinaloa, México. MÉTODOS: Estudio transversal, observacional y analítico realizado en el Hospital General Dr. Bernardo J. Gastélum de Culiacán entre el 1 de octubre y el 2 de diciembre de 2003. Se evaluó la asociación entre las variables independientes (las características clínicas y epidemiológicas de los pacientes y la variable dependiente (diagnóstico confirmado de dengue hemorrágico mediante el análisis de regresión simple. Las variables que mostraron una relación significativa (P 100 000/mm3 en casos con cuadros clínicos graves (fuga capilar que no se clasificaron como dengue hemorrágico por no cumplir todos los criterios establecidos por la OMS.OBJECTIVES: To document the clinical and epidemiological characteristics present in dengue patients served by a hospital in Culiacan, Sinaloa, Mexico. METHODS: A cross-sectional, observational, and analytical study was carried out at the Hospital General Dr. Bernardo J. Gastélum de Culiacan from 1 October to 2 December 2003. Associations between the independent variables (the patients' clinical and epidemiological characteristics and the dependent variable (confirmed hemorrhagic dengue were determined through simple regression analysis. The variables that were significantly associated (P 100000/mm3 were confirmed in cases with acute clinical symptoms (capillary leak that were not classified as hemorrhagic dengue due to falling short of the criteria established by WHO.

  1. Enhanced severity of secondary dengue-2 infections: death rates in 1981 and 1997 Cuban outbreaks Aumento de la gravedad de las infecciones secundarias por dengue-2: tasas de mortalidad en los brotes cubanos de 1981 y 1997

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    María G. Guzmán

    2002-04-01

    todos. Se compararon las tasas de mortalidad y hospitalización por dengue hemorrágico/síndrome de choque por dengue (DH/SCD de las infecciones secundarias por dengue-2 (DEN-2 en el mismo grupo de edad en dos epidemias de DEN-2 ocurridas en Cuba. La primera afectó a todo el país en 1981, mientras que la segunda, de 1997, solo afectó a la ciudad de Santiago de Cuba. La infección sensibilizante para el DH/SCD en cada una de las dos epidemias fue el virus del dengue del serotipo 1 (DEN-1, que se transmitió entre 1977 y 1979, o sea, 4 años y 20 años antes de la primera y la segunda epidemias de DEN-2, respectivamente. Utilizando datos seroepidemiológicos publicados referidos a las ciudades de La Habana y Santiago, se estimaron las tasas de mortalidad y de hospitalización por DH/SCD en personas de 15-39 años y en mayores de 40 años de La Habana y de toda Cuba en 1981, y solo de Santiago en 1997. Resultados. En los adultos de 15 a 39 años, la tasa de mortalidad por 10 000 habitantes correspondiente a las infecciones secundarias por DEN-2 fue 38,5 veces mayor en Santiago en 1997 que en La Habana en 1981. Otro indicio del aumento de la sensibilidad a medida que aumenta el tiempo transcurrido entre la infección inicial por DEN-1 y la infección secundaria por DEN-2 fue el hecho de que la tasa de letalidad del mismo grupo de edad fuera 4,7 veces mayor en Santiago en 1997 que en La Habana en 1981. Conclusiones. Observamos un marcado aumento de la gravedad con el mayor intervalo (20 años entre la infección inicial por DEN-1 y la infección secundaria por DEN-2. Esta diferencia puede deberse a pequeñas diferencias entre las cepas causales del virus del dengue o a cambios de los anticuerpos humanos anti-dengue circulantes en la población a medida que pasa el tiempo. Estas observaciones tienen importantes implicaciones en el control del dengue, en los mecanismos patógenos de la enfermedad y en el desarrollo de vacunas.

  2. Epidemiology of dengue: past, present and future prospects

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    Murray NE

    2013-08-01

    Full Text Available Natasha Evelyn Anne Murray,1,2 Mikkel B Quam,1 Annelies Wilder-Smith1,31Institute of Public Health, University of Heidelberg, Heidelberg, Germany; 2Population Health, Waikato District Health Board, Hamilton, New Zealand; 3Lee Kong Chian School of Medicine, Nanyang Technological University, SingaporeAbstract: Dengue is currently regarded globally as the most important mosquito-borne viral disease. A history of symptoms compatible with dengue can be traced back to the Chin Dynasty of 265–420 AD. The virus and its vectors have now become widely distributed throughout tropical and subtropical regions of the world, particularly over the last half-century. Significant geographic expansion has been coupled with rapid increases in incident cases, epidemics, and hyperendemicity, leading to the more severe forms of dengue. Transmission of dengue is now present in every World Health Organization (WHO region of the world and more than 125 countries are known to be dengue endemic. The true impact of dengue globally is difficult to ascertain due to factors such as inadequate disease surveillance, misdiagnosis, and low levels of reporting. Currently available data likely grossly underestimates the social, economic, and disease burden. Estimates of the global incidence of dengue infections per year have ranged between 50 million and 200 million; however, recent estimates using cartographic approaches suggest this number is closer to almost 400 million. The expansion of dengue is expected to increase due to factors such as the modern dynamics of climate change, globalization, travel, trade, socioeconomics, settlement and also viral evolution. No vaccine or specific antiviral therapy currently exists to address the growing threat of dengue. Prompt case detection and appropriate clinical management can reduce the mortality from severe dengue. Effective vector control is the mainstay of dengue prevention and control. Surveillance and improved reporting of dengue

  3. Evaluation of concurrent malaria and dengue infections among febrile patients

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    Parul D Shah

    2017-01-01

    Full Text Available Context: Despite a wide overlap between endemic areas for two important vector-borne infections, malaria and dengue, published reports of co-infections are scarce till date. Aims: To find the incidence of dengue and malaria co-infection as well as to ascertain the severity of such dengue and malaria co-infection based on clinical and haematological parameters. Setting and Design: Observational, retrospective cross-sectional study was designed including patients who consulted the tertiary care hospital of Ahmedabad seeking treatment for fever compatible with malaria and/or dengue. Subjects and Methods: A total of 8364 serum samples from clinically suspected cases of fever compatible with malaria and/or dengue were collected. All samples were tested for dengue NS-1 antigen before 5 days of onset of illness and for dengue IgM after 5 days of onset of illness. In all samples, malaria diagnosis was based on the identification of Plasmodium parasites on a thin and thick blood films microscopy. Results: Only 10.27% (859 patients with fever were tested positive for dengue and 5.1% (434 were tested positive for malaria. 3.14% (27 dengue cases show concurrent infection with malarial parasites. Hepatomegaly and jaundice 37.03% (10, haemorrhagic manifestations 18.51% (5 and kidney failure 3.7% (1, haemoglobin <12 g/dl 100% (27 and thrombocytopenia (platelet count <150,000/cmm 96.29% (26 were common in malaria and dengue co-infections and were much more common in Plasmodium falciparum infections. Conclusion: All febrile patients must be tested for malaria and dengue, both otherwise one of them will be missed in case of concurrent infections which could lead to severe diseases with complications.

  4. Sensorineural hearing loss in hemorrhagic dengue?

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    Bruna Natália Freire Ribeiro

    2015-01-01

    Discussion and conclusion: This is the first case report that brings together DHF and sudden hearing loss. In the development of this case no other cause to sudden hearing loss was found and the correlation between dengue and hearing loss was questioned. In the literature review was found that some viruses, as mumps virus, varicella-zoster virus and HSV-1 and HSV-2 are related to sudden hearing loss, all of them fit in the viral theory. Besides the viral theory of sudden hearing loss, there is the vascular theory that is the occlusion of the end artery that supplies the cochlea. DHF has a vascular commitment, and the hypothesis of a vascular cause could be elicited in this case. Many studies in this area are needed and this article has the objective of elicit the discussion about the subject. Could dengue be associated with sensorineural hearing loss?

  5. The Medicinal Chemistry of Dengue Virus.

    Science.gov (United States)

    Behnam, Mira A M; Nitsche, Christoph; Boldescu, Veaceslav; Klein, Christian D

    2016-06-23

    The dengue virus and related flaviviruses are an increasing global health threat. In this perspective, we comment on and review medicinal chemistry efforts aimed at the prevention or treatment of dengue infections. We include target-based approaches aimed at viral or host factors and results from phenotypic screenings in cellular assay systems for viral replication. This perspective is limited to the discussion of results that provide explicit chemistry or structure-activity relationship (SAR), or appear to be of particular interest to the medicinal chemist for other reasons. The discovery and development efforts discussed here may at least partially be extrapolated toward other emerging flaviviral infections, such as West Nile virus. Therefore, this perspective, although not aimed at flaviviruses in general, should also be able to provide an overview of the medicinal chemistry of these closely related infectious agents.

  6. Dengue Virus Glycosylation: What Do We Know?

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    Sally S. L. Yap

    2017-07-01

    Full Text Available In many infectious diseases caused by either viruses or bacteria, pathogen glycoproteins play important roles during the infection cycle, ranging from entry to successful intracellular replication and host immune evasion. Dengue is no exception. Dengue virus glycoproteins, envelope protein (E and non-structural protein 1 (NS1 are two popular sub-unit vaccine candidates. E protein on the virion surface is the major target of neutralizing antibodies. NS1 which is secreted during DENV infection has been shown to induce a variety of host responses through its binding to several host factors. However, despite their critical role in disease and protection, the glycosylated variants of these two proteins and their biological importance have remained understudied. In this review, we seek to provide a comprehensive summary of the current knowledge on protein glycosylation in DENV, and its role in virus biogenesis, host cell receptor interaction and disease pathogenesis.

  7. Evaluación de la definición clínica de dengue sugerida por la Organización Mundial de la Salud.

    OpenAIRE

    Ruth Aralí Martínez; Fredi Alexander Díaz; Luis Angel Villar

    2005-01-01

    Introducción. Clínicamente es difícil diferenciar el dengue de otras entidades con sintomatología similar. Objetivo. Evaluar la utilidad diagnóstica de la definición de caso presunto de dengue sugerida por la Organización Mundial de la Salud, en un área endémica (Bucaramanga, Colombia). Materiales y métodos. En una cohorte con síndrome febril agudo sin causa aparente (mayores de 12 años), se determinó la sensibilidad, la especificidad y los valores pronósticos de dicha definición que incluye ...

  8. 75 FR 6211 - Prospective Grant of Exclusive License: Purified Inactivated Dengue Tetravalent Vaccine...

    Science.gov (United States)

    2010-02-08

    ... Exclusive License: Purified Inactivated Dengue Tetravalent Vaccine Containing a Common 30 Nucleotide Deletion in the 3'-UTR of Dengue Types 1,2,3, and 4 AGENCY: National Institutes of Health, Public Health...., ``Development of Mutations Useful for Attenuating Dengue Viruses and Chimeric Dengue Viruses''-- European Patent...

  9. Dengue risk factors and community participation in Binh Thuan Province, Vietnam, a household survey

    NARCIS (Netherlands)

    Phuong, Hoang Lan; de Vries, Peter J.; Boonshuyar, Chaweewon; Binh, Tran Q.; Nam, Nguyen V.; Kager, Piet A.

    2008-01-01

    To look for risk factors for dengue and community participation in dengue control in Binh Thuan Province, Vietnam, three communes with a low incidence of dengue and three with a high incidence, in Binh Thuan Province, were compared. Knowledge, perception and preventive practice of dengue were

  10. Pharmacological intervention for dengue virus infection.

    Science.gov (United States)

    Lai, Jenn-Haung; Lin, Yi-Ling; Hsieh, Shie-Liang

    2017-04-01

    Dengue virus (DENV) infection has a considerable health impact in tropical and subtropical countries worldwide. Escalation of infection rates greatly increases morbidity and mortality, most commonly from deaths due to dengue hemorrhagic fever and dengue shock syndrome. Although the development of an effective, long-lasting vaccine has been a major aim for control and prevention of DENV infection, the currently licensed vaccine has limitations and is less than satisfactory. Thus, there remains an important need to identify effective and tolerable medications for treatment of DENV-infected patients both in the early phase, to prevent progression to fatal outcomes, and to minimize deaths after patients develop severe complications. This review will address several specific points, including (1) approaches to identify anti-DENV medications, (2) recent advances in the development of potential compounds targeting DENV infection, (3) experience with clinical trials of regimens for DENV infection, (4) some available medications of potential for clinical trials against DENV infection, (5) reasons for unsuccessful outcomes and challenges of anti-DENV treatments, and (6) directions for developing or selecting better anti-DENV strategies. This review provides useful guidance for clinicians selecting drugs for DENV-infected patients with severe manifestations or potential fatal disease progression, and for basic researchers seeking to develop effective anti-DENV regimens. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. 'La fiebre de Malta': An Interface of Farmers and Caprine Brucellosis Control Policies in the Bajío Region, Mexico.

    Science.gov (United States)

    Oseguera Montiel, D; Udo, H M J; Frankena, K; van der Zijpp, A

    2017-02-01

    This article shows that socio-economic factors, defined here as practices, knowledge, interests, beliefs and experiences have a role in the adoption of brucellosis control strategies in the Bajío region, Mexico. We combined qualitative and quantitative methods to show that socio-economic factors with regard to goat husbandry and brucellosis control are not taken into account in the current policy to combat the disease in Mexico. Farmers ranked constraints like the price of goat milk more important than the control of the disease. The impact of brucellosis in goats is hidden to farmers, and the term brucellosis is still a strange name to them; it is better known as 'la fiebre de Malta' (Malta fever), which farmers are aware of and which they avoid by not drinking goat milk. Brucellosis control measures cause losses such as abortion due to vaccination and ear infections due to ear tagging. In the villages of the state of Michoacán, the uptake of a vaccination and testing programme was almost complete because it was offered for free, whereas in villages of Jalisco, vaccination was not adopted thoroughly because the cost of vaccination was high for farmers and because of a lack of veterinarians offering the service. Neither compensation for culling suspected infected goats does exist nor the infrastructure, like slaughterhouses, to ensure that goats that are brucellosis seropositive are not resold to neighbouring farmers. This article disputes the idea that brucellosis is confined to the lack of awareness and participation of farmers in control measures, but rather that policies are promulgated without a good knowledge of goat husbandry and farmers' perceptions. We claim that governmental authorities should reformulate the policy to take into account socio-economic factors shaping farmers' behaviour so that effective control measures will be adopted by goat farmers. © 2015 Blackwell Verlag GmbH.

  12. Challenges in dengue fever in the elderly: atypical presentation and risk of severe dengue and hospital-acquired infection [corrected].

    Directory of Open Access Journals (Sweden)

    Emily K Rowe

    2014-04-01

    Full Text Available BACKGROUND/METHODS: To better understand dengue fever in the elderly, we compared clinical features, World Health Organization (WHO dengue classification and outcomes between adult (<60 and elderly (≥60 dengue patients. We explored the impact of co-morbidity and hospital-acquired infection (HAI on clinical outcomes in the elderly. All patients managed at the Communicable Disease Centre, Singapore, between 2005 and 2008 with positive dengue polymerase chain reaction (PCR or who fulfilled WHO 1997 or 2009 probable dengue criteria with positive dengue IgM were included. RESULTS: Of the 6989 cases, 295 (4.4% were elderly. PCR was positive in 29%. The elderly suffered more severe disease with more dengue haemorrhagic fever (DHF (29.2% vs. 21.4% and severe dengue (SD (20.3% vs. 14.6% (p<0.05. Classic dengue symptoms were more common in the adult group. The elderly were less likely to fulfill WHO 1997 (93.6% vs. 96.4% (p = 0.014, but not WHO 2009 probable dengue (75.3% vs. 71.5%. Time to dengue diagnosis was similar. There was no significant difference in the frequency of warning signs between the two groups, but the elderly were more likely to have hepatomegaly (p = 0.006 and malaise/lethargy (p = 0.033 while the adults had significantly more mucosal bleeding (p<0.001. Intensive care admission occurred in 15 and death in three, with no age difference. Notably, the elderly stayed in hospital longer (median 5 vs. 4 days, and suffered more pneumonia (3.8% vs. 0.7% and urinary infection (1.9% vs. 0.3% (p = 0.003. Predictors of excess length of stay were age (adjusted odds ratio [aOR] 2.01, 95% confidence interval [CI] 1.37-2.88, critical illness (aOR 5.13, 95%CI 2.59-9.75, HAI (aOR 12.06, 95%CI 7.39-19.9, Charlson score (aOR 6.9, 95%CI 2.02-22.56 and severe dengue (DHF/dengue shock syndrome/SD (aOR 2.24, 95%CI 1.83-2.74. CONCLUSION: Elderly dengue patients present atypically and are at higher risk of DHF, SD and HAI. Aside from dengue

  13. Clinical predictors of dengue fever co-infected with leptospirosis among patients admitted for dengue fever - a pilot study.

    Science.gov (United States)

    Suppiah, Jeyanthi; Chan, Shie-Yien; Ng, Min-Wern; Khaw, Yam-Sim; Ching, Siew-Mooi; Mat-Nor, Lailatul Akmar; Ahmad-Najimudin, Naematul Ain; Chee, Hui-Yee

    2017-06-28

    Dengue and leptospirosis infections are currently two major endemics in Malaysia. Owing to the overlapping clinical symptoms between both the diseases, frequent misdiagnosis and confusion of treatment occurs. As a solution, the present work initiated a pilot study to investigate the incidence related to co-infection of leptospirosis among dengue patients. This enables the identification of more parameters to predict the occurrence of co-infection. Two hundred sixty eight serum specimens collected from patients that were diagnosed for dengue fever were confirmed for dengue virus serotyping by real-time polymerase chain reaction. Clinical, laboratory and demographic data were extracted from the hospital database to identify patients with confirmed leptospirosis infection among the dengue patients. Thus, frequency of co-infection was calculated and association of the dataset with dengue-leptospirosis co-infection was statistically determined. The frequency of dengue co-infection with leptospirosis was 4.1%. Male has higher preponderance of developing the co-infection and end result of shock as clinical symptom is more likely present among co-infected cases. It is also noteworthy that, DENV 1 is the common dengue serotype among all cases identified as dengue-leptospirosis co-infection in this study. The increasing incidence of leptospirosis among dengue infected patients has posed the need to precisely identify the presence of co-infection for the betterment of treatment without mistakenly ruling out either one of them. Thus, anticipating the possible clinical symptoms and laboratory results of dengue-leptospirosis co-infection is essential.

  14. Knowledge of dengue among students in Universiti Sultan Zainal ...

    African Journals Online (AJOL)

    Reducing the vector population not only organization responsible, individual itself plays as important role in dengue prevention and control. Upon the understanding of the value of baseline data, a cross-sectional study was carried out in the dengue hotspot areas in Universiti Sultan Zainal Abidin (UniSZA). The study results ...

  15. Dengue in the United States of America: A Worsening Scenario?

    Directory of Open Access Journals (Sweden)

    Germán Añez

    2013-01-01

    Full Text Available Dengue is a febrile illness caused by any of the four dengue virus types (DENV-1 to -4, genus Flavivirus, family Flaviviridae mainly transmitted by the mosquito Aedes aegypti. DENV can be transmitted by blood transfusion. Dengue has been historically present in the continental United States (US, in the state of Hawaii, and in the US insular territories in the Caribbean and the Pacific. During the second half of the 20th century, most of the cases reported in the US were imported cases brought to the country by travelers. Since 2009, cases of autochthonous dengue have been recognized in the state of Florida after 75 years of absence, followed by intensification of transmission in endemic places including the US territories of US Virgin Islands and Puerto Rico, which experienced a large dengue epidemic in 2010. The widespread distribution of dengue mosquito vectors, deficient mosquito control measures and increased frequency of DENV-infected visitors to the US coming from dengue-endemic locations or places experiencing epidemics appear to be jointly responsible for the emergence and reemergence of dengue in the US and its territories.

  16. Emergence of Dengue virus serotype 3 on Mayotte Island, Indian ...

    African Journals Online (AJOL)

    A serosurvey carried out in 2006 in Mayotte, a French overseas collectivity in the Indian Ocean, confirmed previous circulation of dengue virus (DENV) on the island, but since the set up of a laboratory-based surveillance of dengue-like illness in 2007, no case of DENV has been confirmed. In response to an outbreak of ...

  17. Isolation of Ancestral Sylvatic Dengue Virus Type 1, Malaysia

    Science.gov (United States)

    Teoh, Boon-Teong; Sam, Sing-Sin; Abd-Jamil, Juraina

    2010-01-01

    Ancestral sylvatic dengue virus type 1, which was isolated from a monkey in 1972, was isolated from a patient with dengue fever in Malaysia. The virus is neutralized by serum of patients with endemic DENV-1 infection. Rare isolation of this virus suggests a limited spillover infection from an otherwise restricted sylvatic cycle. PMID:21029545

  18. Impaired fibrinolysis in the pathogenesis of dengue hemorrhagic fever.

    NARCIS (Netherlands)

    Gorp, E. van; Setiati, T.E.; Mairuhu, A.T.; Suharti, C.; Cate, H.H.; Dolmans, W.M.V.; Meer, J.W.M. van der; Hack, C.E.; Brandjes, D.P.

    2002-01-01

    The mechanisms contributing to bleeding complications in dengue hemorrhagic fever were studied by investigating the pattern of activation of the coagulation and fibrinolytic systems in 50 children with severe dengue hemorrhagic fever. Thirteen patients (26%) died, and activation of coagulation was

  19. Impaired fibrinolysis in the pathogenesis of dengue hemorrhagic fever

    NARCIS (Netherlands)

    van Gorp, Eric C. M.; Setiati, Tatty E.; Mairuhu, Albert T. A.; Suharti, Catharina; Cate Ht, Hugo ten; Dolmans, Wil M. V.; van der Meer, Jos W. M.; Hack, C. Erik; Brandjes, Dees P. M.

    2002-01-01

    The mechanisms contributing to bleeding complications in dengue hemorrhagic fever were studied by investigating the pattern of activation of the coagulation and fibrinolytic systems in 50 children with severe dengue hemorrhagic fever. Thirteen patients (26%) died, and activation of coagulation was

  20. Therapeutic antibodies as a treatment option for dengue fever.

    Science.gov (United States)

    Chan, Kuan Rong; Ong, Eugenia Z; Ooi, Eng Eong

    2013-11-01

    Dengue fever is the most prevalent mosquito-borne viral disease globally with about 100 million cases of acute dengue annually. Severe dengue infection can result in a life-threatening illness. In the absence of either a licensed vaccine or antiviral drug against dengue, therapeutic antibodies that neutralize dengue virus (DENV) may serve as an effective medical countermeasure against severe dengue. However, therapeutic antibodies would need to effectively neutralize all four DENV serotypes. It must not induce antibody-dependent enhancement of DENV infection in monocytes/macrophages through Fc gamma receptor (FcγR)-mediated phagocytosis, which is hypothesized to increase the risk of severe dengue. Here, we review the strategies and technologies that can be adopted to develop antibodies for therapeutic applications. We also discuss the mechanism of antibody neutralization in the cells targeted by DENV that express Fc gamma receptor. These studies have provided significant insight toward the use of therapeutic antibodies as a potentially promising bulwark against dengue.

  1. Dengue Outbreak in Hadramout, Yemen, 2010: An Epidemiological Perspective

    Science.gov (United States)

    Ghouth, Abdulla Salim Bin; Amarasinghe, Ananda; Letson, G. William

    2012-01-01

    We analyzed surveillance data of a dengue outbreak (2010) reported to the Hadramout Health Office (Yemen) and retrospectively analyzed dengue-related epidemiological and entomological events reported in Hadramout from 2005 to 2009. A total of 630 immunoglobulin M (IgM) -confirmed dengue cases of 982 febrile cases was reported during the period from February to June of 2010; 12 cases died, giving case fatality a rate of 1.9%. Among febrile cases, the highest proportion of dengue cases (37.3%) was reported in the 15- to 24-year-old age group. The overall attack rate was 0.89/1,000. The average number of cases reported by month over the preceding 5-year period compared with the 2010 data is consistent with endemicity of dengue in the region and supports epidemic designation for the dengue activity in 2010. Recognition of endemic dengue transmission and potential for substantial dengue epidemics highlight the need for consistent laboratory-based surveillance that can support prevention and control activities accordingly. PMID:22665621

  2. Projections of increased and decreased dengue incidence under climate change.

    Science.gov (United States)

    Williams, C R; Mincham, G; Faddy, H; Viennet, E; Ritchie, S A; Harley, D

    2016-10-01

    Dengue is the world's most prevalent mosquito-borne disease, with more than 200 million people each year becoming infected. We used a mechanistic virus transmission model to determine whether climate warming would change dengue transmission in Australia. Using two climate models each with two carbon emission scenarios, we calculated future dengue epidemic potential for the period 2046-2064. Using the ECHAM5 model, decreased dengue transmission was predicted under the A2 carbon emission scenario, whereas some increases are likely under the B1 scenario. Dengue epidemic potential may decrease under climate warming due to mosquito breeding sites becoming drier and mosquito survivorship declining. These results contradict most previous studies that use correlative models to show increased dengue transmission under climate warming. Dengue epidemiology is determined by a complex interplay between climatic, human host, and pathogen factors. It is therefore naive to assume a simple relationship between climate and incidence, and incorrect to state that climate warming will uniformly increase dengue transmission, although in general the health impacts of climate change will be negative.

  3. Dengue Knowledge and Preventive Practices in Iquitos, Peru.

    Science.gov (United States)

    Paz-Soldán, Valerie A; Morrison, Amy C; Cordova Lopez, Jhonny J; Lenhart, Audrey; Scott, Thomas W; Elder, John P; Sihuincha, Moises; Kochel, Tadeusz J; Halsey, Eric S; Astete, Helvio; McCall, Philip J

    2015-12-01

    As part of a cluster-randomized trial to evaluate insecticide-treated curtains for dengue prevention in Iquitos, Peru, we surveyed 1,333 study participants to examine knowledge and reported practices associated with dengue and its prevention. Entomological data from 1,133 of these households were linked to the survey. Most participants knew that dengue was transmitted by mosquito bite (85.6%), but only few (18.6%) knew that dengue vectors bite during daytime. Most commonly recognized dengue symptoms were fever (86.6%), headache (76.4%), and muscle/joint pain (67.9%). Most commonly reported correct practices for mosquito control were cleaning homes (61.6%), using insecticide sprays (23%), and avoiding having standing water at home (12.3%). Higher education was associated with higher knowledge about dengue, including transmission and vector control. Higher socioeconomic status was associated with increased reported use of preventive practices requiring money expenditure. We were less likely to find Aedes aegypti eggs, larvae, or pupae in households that had dengue has been transmitted in Iquitos since the 1990s and the Regional Health Authority routinely fumigates households, treats domestic water containers with larvicide, and issues health education messages through mass media, knowledge of dengue transmission and household practices for prevention could be improved. © The American Society of Tropical Medicine and Hygiene.

  4. Potential biomarkers for the clinical prognosis of severe dengue

    Directory of Open Access Journals (Sweden)

    Mayara Marques Carneiro da Silva

    2013-09-01

    Full Text Available Currently, several assays can confirm acute dengue infection at the point-of-care. However, none of these assays can predict the severity of the disease symptoms. A prognosis test that predicts the likelihood of a dengue patient to develop a severe form of the disease could permit more efficient patient triage and treatment. We hypothesise that mRNA expression of apoptosis and innate immune response-related genes will be differentially regulated during the early stages of dengue and might predict the clinical outcome. Aiming to identify biomarkers for dengue prognosis, we extracted mRNA from the peripheral blood mononuclear cells of mild and severe dengue patients during the febrile stage of the disease to measure the expression levels of selected genes by quantitative polymerase chain reaction. The selected candidate biomarkers were previously identified by our group as differentially expressed in microarray studies. We verified that the mRNA coding for CFD, MAGED1, PSMB9, PRDX4 and FCGR3B were differentially expressed between patients who developed clinical symptoms associated with the mild type of dengue and patients who showed clinical symptoms associated with severe dengue. We suggest that this gene expression panel could putatively serve as biomarkers for the clinical prognosis of dengue haemorrhagic fever.

  5. Immune Activation in the Pathogenesis of Dengue Virus Infection

    NARCIS (Netherlands)

    C.A.M. van de Weg (Cornelia A.M.)

    2014-01-01

    markdownabstract__Abstract__ Dengue virus (DENV) is a positive-stranded RNA virus and belongs to the Flaviviridae family. The virus is transmitted by the bite of an infected Aedes-mosquito and circulates in tropical and subtropical areas around the world. The incidence of dengue has risen

  6. Dengue virus exposure among blood donors in Ghana | Narkwa ...

    African Journals Online (AJOL)

    Dengue is an urban arbovirus whose aetiologic agent is the flavivirus with four distinct antigen serotypes (DENV-1, DENV-2, DENV-3 and DENV-4) that is transmitted to humans through the bite of the mosquito Aedes aegypti. Ghana is endemic for Aedes aegypti mosquitoes and probably dengue viruses. Due to limited data ...

  7. Deranged liver among Sudanese patients with dengue virus ...

    African Journals Online (AJOL)

    Background: Deranged liver is a well-recognized feature of dengue infection, often demonstrated by coagulopathy and mild to moderate increase in transaminase levels although jaundice and fulminant hepatic failure are generally uncommon. Objective: This study aimed to evaluate the hepatic effect of dengue fever ...

  8. Ludwig's angina after severe thrombocytopenic purpura associated with dengue fever

    Directory of Open Access Journals (Sweden)

    Maria Antonia Campos

    2014-01-01

    Full Text Available Here, we report a case of Ludwig's angina, which required surgery because of toothache. The patient had dengue and severe thrombocytopenia as confirmed by clinical and laboratory diagnoses. However, dengue is not included among the predisposing factors for Ludwig's angina.

  9. Socio-demographic determinants of dengue infection during an ...

    African Journals Online (AJOL)

    Dell

    4Southern African Centre for Infectious Disease Surveillance, Africa Centre of Excellence for Infectious Diseases of. Humans and ..... Erlanger, T.E., Keiser, J. & Utzinger, J. (2008) Effect of dengue vector control interventions on ... Dengue fever among hospitalized febrile patients in northern Tanzania. American Journal of.

  10. Genetic analysis of imported dengue virus strains by Iranian travelers

    Directory of Open Access Journals (Sweden)

    Nariman Shahhosseini

    2016-11-01

    Full Text Available Dengue virus sequences used in this study were obtained from two Iranian patients who were both with a history of traveling to Malaysia. The maximum likelihood phylogenetic tree demonstrated that two sequences were grouped into dengue virus 1. Specifically, strains IranDF1 and Iran-DF2 clustered in genotype I and III, respectively.

  11. Climate Variability, Social Change and Dengue in Bangladesh ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Researchers will carry out a serological study in nine city wards in Dhaka with different levels of dengue virus transmission; a clinical study of suspected cases of dengue in two hospitals; entomological surveys in the nine wards already mentioned; and an ethnographic study in three wards to examine the social and ...

  12. Dengue as a cause of acute undifferentiated fever in Vietnam

    NARCIS (Netherlands)

    Phuong, H.L.; de Vries, P.J.; Nga, T.T.T.; Giao, P.T.; Hung, L.Q.; Binh, T.Q.; Nam, N.V.; Nagelkerke, N.; Kager, P.A.

    2006-01-01

    Background: Dengue is a common cause of fever in the tropics but its contribution to the total burden of febrile illnesses that is presented to primary health facilities in endemic regions such as Vietnam, is largely unknown. We aimed to report the frequency of dengue as a cause of fever in Binh

  13. Dengue fever associated with acute scrotal oedema: two case reports

    International Nuclear Information System (INIS)

    Shamim, M.; Naqvi, S.Z.G.

    2011-01-01

    Scrotal oedema associated with dengue fever is a rare and self limiting condition resolving in a few days without any complication or sequelae. This is a report of two cases of dengue fever associated with acute scrotal and penile oedema. (author)

  14. Dengue data and surveillance in Tanzania: a systematic literature review.

    Science.gov (United States)

    Ward, Tara; Samuel, Moody; Maoz, Dorit; Runge-Ranzinger, Silvia; Boyce, Ross; Toledo, Joao; Velayudhan, Raman; Horstick, Olaf

    2017-08-01

    Although there is evidence that dengue virus is circulating in Tanzania, the country lacks a dengue surveillance system. Consequently, the true estimate of dengue seroprevalence, as well as the incidence in the population, the frequency and magnitude of outbreaks is unknown. This study therefore sought to systematically review available dengue data from Tanzania. The systematic review was conducted and reported using the PRISMA tool. Five databases (PubMed, Embase, Web of Science, WHOLIS and Google Scholar) were searched for articles using various keywords on the illness, data and geographical location. Identified articles were assessed for inclusion based on predefined eligibility criteria. Data were extracted from included articles, analysed and reported. Based on the 10 seroprevalence studies in defined populations with estimates of acute confirmed infections that were included in the review, the estimated seroprevalence of past dengue infection in Tanzania ranged from 50.6% in a health facility-based study to 11% in a population-based study. Acute confirmed infections of dengue were estimated to be as high as 38.2% of suspected cases. Only one study reported on an outbreak. It is evident that dengue needs to become part of regular disease surveillance in Tanzania. Control measures need to be instituted with a focus on building human resource capacity and integrating dengue control measures in ongoing health programmes, for both preventive and curative interventions. Systematic reviews are valuable in assessing health issues when surveillance data are not available. © 2017 John Wiley & Sons Ltd.

  15. Dengue as a cause of acute undifferentiated fever in Vietnam

    NARCIS (Netherlands)

    Phuong, Hoang Lan; de Vries, Peter J.; Nga, Tran T. T.; Giao, Phan T.; Hung, Le Q.; Binh, Tran Q.; Nam, Nguyen V.; Nagelkerke, Nico; Kager, Piet A.

    2006-01-01

    BACKGROUND: Dengue is a common cause of fever in the tropics but its contribution to the total burden of febrile illnesses that is presented to primary health facilities in endemic regions such as Vietnam, is largely unknown. We aimed to report the frequency of dengue as a cause of fever in Binh

  16. Investigation of spatiotemporal relationship between dengue fever and drought

    Science.gov (United States)

    Lee, Chieh-Han; Yu, Hwa-Lung

    2016-04-01

    Dengue Fever is a vector-borne disease that is transmitted between human and mosquitos in tropical and sub-tropical regions. Previous studies have found significant relationship between the epidemic of dengue cases and climate variables, especially temperature and precipitation. Besides, the natural phenomena (e.g., drought) are considered that significantly drop the number of dengue cases by killing vector's breeding environment. However, in Kaohsiung City, Taiwan, there are evidences that the temporal pattern of dengue is correlated to drought events. Kaohsiung City experienced two main dengue outbreaks in 2002 and 2014 that both years were confirmed with serious drought. Especially in 2014, Kaohsiung City was suffered from extremely dengue outbreak in 2014 that reported the highest number of dengue cases in the history. Otherwise, another nearby city, Tainan City, had reported the biggest outbreak in 2015. This study constructs the spatiotemporal model of dengue incidences and index of drought events (Standardized Precipitation Index, SPI) based on the distributed lag nonlinear model (DLNM). Other meteorological measures are also included in the analysis.

  17. Climate Variability, Social Change and Dengue in Bangladesh ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Since the year 2000, the major cities of Bangladesh have experienced a resurgence of dengue. Dengue is a major public health concern because of its epidemic potential in any one year, and because of the limited understanding of disease transmission dynamics in the country. This project aims to advance knowledge on ...

  18. El veneno y el mosquito: aspectos epistemológicos de la etiología y la profilaxis de la fiebre amarilla Poison and the mosquito: epistemological aspects of the etiology and prophylactics of yellow fever

    OpenAIRE

    Sandra Caponi

    2000-01-01

    En el II Congreso Médico Latinoamericano (Buenos Aires, 1904) se discutieron las estrategias que Argentina y Brasil delinearon para combatir la fiebre amarilla. El análisis de la controversia entre sanitaristas brasileños y argentinos en torno a los modelos explicativos y a las estrategias de profilaxis internacional de esa enfermedad, nos permite una comprensión epistemológica de la ruptura operada por la emergencia de la medicina de los vectores. Este capítulo de la historia de la medicina ...

  19. Experiencias en las etapas de control y sostenibilidad de la epidemia de Dengue

    Directory of Open Access Journals (Sweden)

    Pablo León Cabrera

    Full Text Available Introducción: el dengue es uno de los problemas de salud prioritarios debido al incremento en el reporte de casos, la aparición de epidemias en nuevas áreas geográficas, con la consecuente extensión del vector y la transmisión de la enfermedad. Cuba ha trabajado durante muchos años para mantener al país libre de transmisión de Dengue. Objetivo: diseñar un grupo de acciones para fortalecer la estrategia en la etapa de control y sostenibilidad de la epidemia de dengue en el área de salud del Policlínico "Héroes del Moncada". Método: se realizó un estudio epidemiológico descriptivo transversal en el área de salud del Policlínico "Héroes del Moncada", durante el año 2012. Se tomó como punto de partida el diagnóstico de la situación epidemiológica basado en 6 áreas clave de la estrategia: análisis clínico, epidemiológico, entomológico y ambiental de los riesgos; el tratamiento focal; el trabajo del adulticida; el tratamiento extradomiciliario, el trabajo entomológico; la participación comunitaria e intersectorial. Las técnicas utilizadas fueron las entrevistas a profundidad con su análisis cualitativo, y el análisis cuantitativo y cualitativo. Se confeccionaron gráficos con los pronósticos y las tendencias. Resultados: se elaboraron acciones tomando como elementos básicos los documentos normativos emitidos por el MINSAP, los criterios de expertos en el tema y el resultado de investigaciones avaladas a nivel internacional y nacional, así como la estrategia municipal confeccionada por los profesores de la ENSAP y el municipio de salud. Se confeccionaron e implementaron acciones en las etapas vitales para minimizar los riesgos potenciales y controlar la transmisión de la enfermedad, con la participación activa de todos los entes imbricados, estimulando el desarrollo del pensamiento salubrista. Conclusiones: la implementación de estas acciones es un ejercicio teórico-práctico que logra la organización de todos

  20. Findings at brain MRI in children with dengue fever and neurological symptoms

    Energy Technology Data Exchange (ETDEWEB)

    Rastogi, Ruchi; Garg, Bhavya [Indraprastha Apollo Hospitals, Department of Radiodiagnosis, New Delhi (India)

    2016-01-15

    Dengue is a flavivirus of the genus arbovirus with four serotypes, from DEN 1 to DEN 4. There has been an increase in incidence of dengue infection in children in the tropics and subtropics. Dengue has a variable clinical presentation, with many patients being asymptomatic. Its clinical manifestations in children vary from fever and arthralgia to life-threatening dengue hemorrhagic fever and dengue shock syndrome. We describe MRI findings in children with neurological involvement including dengue encephalopathy, acute hypoxic injury and dengue encephalitis. Dengue encephalopathy is usually secondary to multisystem derangement such as shock, hepatitis, coagulopathy and concurrent bacterial infection and is relatively common. Dengue encephalitis from direct neuronal invasion is rare. Nonspecific changes are seen on brain MRI in dengue infection. Clinical and laboratory findings as well as outcome do not necessarily correspond with brain MRI findings. (orig.)

  1. Findings at brain MRI in children with dengue fever and neurological symptoms

    International Nuclear Information System (INIS)

    Rastogi, Ruchi; Garg, Bhavya

    2016-01-01

    Dengue is a flavivirus of the genus arbovirus with four serotypes, from DEN 1 to DEN 4. There has been an increase in incidence of dengue infection in children in the tropics and subtropics. Dengue has a variable clinical presentation, with many patients being asymptomatic. Its clinical manifestations in children vary from fever and arthralgia to life-threatening dengue hemorrhagic fever and dengue shock syndrome. We describe MRI findings in children with neurological involvement including dengue encephalopathy, acute hypoxic injury and dengue encephalitis. Dengue encephalopathy is usually secondary to multisystem derangement such as shock, hepatitis, coagulopathy and concurrent bacterial infection and is relatively common. Dengue encephalitis from direct neuronal invasion is rare. Nonspecific changes are seen on brain MRI in dengue infection. Clinical and laboratory findings as well as outcome do not necessarily correspond with brain MRI findings. (orig.)

  2. Agranulocitosis inducida por metimazol en pacientes con enfermedad de Graves

    Directory of Open Access Journals (Sweden)

    Helard Manrique-Hurtado

    2013-04-01

    Full Text Available Objetivo: Describir las características clínicas y epidemiológicas de los pacientes con enfermedad de Graves que presentaron agranulocitosis inducida por metimazol. Material y métodos: Estudio retrospectivo, tipo serie de casos. Se revisaron las historias clínicas de todos los pacientes con diagnóstico de agranulocitosis inducida por metimazol, atendidos en el Hospital Nacional Arzobispo Loayza, entre enero 2002 y diciembre 2008. Se buscó asociación entre las variables demográficas y clínicas con la mortalidad y el tiempo de recuperación. Resultados: Treinta (0,60% pacientes con enfermedad de Graves fueron hospitalizados con el diagnóstico de agranulocitosis inducida por metimazol. La mediana de la edad fue 33,5 años y 86,67% fueron mujeres. Al ingreso, todos los pacientes presentaron fiebre y dolor de garganta. El manejo incluyó aislamiento invertido, suspensión del metimazol, administración de antibióticos y glucocorticoides. Doce (40% pacientes recibieron GM-CSF. El número de granulocitos se normalizó después de 10,59 días y cuatro (13,33% pacientes murieron por infecciones bacterianas y sepsis. En todos los casos, el tratamiento definitivo fue yodo radioactivo. No hubo diferencia significativa en la edad, sexo, dosis de metimazol, duración del tratamiento y uso de factor estimulante colonia, entre los pacientes fallecidos y los sobrevivientes. Además, el uso de factor estimulante de colonia no redujo el tiempo de recuperación de la agranulocitosis. Conclusión: La agranulocitosis inducida por metimazol es un evento adverso serio y potencialmente mortal. En este grupo de pacientes, la mortalidad fue elevada y el uso de factor estimulante de colonia no disminuyó el tiempo de recuperación.

  3. Seroepidemiology of Asymptomatic Dengue Virus Infection in Jeddah, Saudi Arabia

    Directory of Open Access Journals (Sweden)

    Ghazi A. Jamjoom

    2016-01-01

    Full Text Available Background Although virologically confirmed dengue fever has been recognized in Jeddah, Saudi Arabia, since 1994, causing yearly outbreaks, no proper seroepidemiologic studies on dengue virus have been conducted in this region. Such studies can define the extent of infection by this virus and estimate the proportion that may result in disease. The aim of this study was to measure the seroprevalence of past dengue virus infection in healthy Saudi nationals from different areas in the city of Jeddah and to investigate demographic and environmental factors that may increase exposure to infection. Methods Sera were collected from 1984 Saudi subjects attending primary health care centers in six districts of Jeddah. These included general patients of various ages seeking routine vaccinations, antenatal care or treatment of different illnesses excluding fever or suspected dengue. A number of blood donors were also tested. Serum samples were tested by enzyme immunoassay (EIA for IgG antibodies to dengue viruses 1, 2, 3, 4. A questionnaire was completed for each patient recording various anthropometric data and factors that may indicate possible risk of exposure to mosquito bites and dengue infection. Patients with missing data and those who reported a history of dengue fever were excluded from analysis, resulting in a sample of 1939 patients to be analyzed. Results The overall prevalence of dengue virus infection as measured by anti-dengue IgG antibodies from asymptomatic residents in Jeddah was 47.8% (927/1939 and 37% (68/184 in blood donors. Infection mostly did not result in recognizable disease, as only 19 of 1956 subjects with complete information (0.1% reported having dengue fever in the past. Anti dengue seropositivity increased with age and was higher in males than females and in residents of communal housing and multistory buildings than in villas. One of the six districts showed significant increase in exposure rate as compared to the others

  4. Towards antiviral therapies for treating dengue virus infections.

    Science.gov (United States)

    Kaptein, Suzanne Jf; Neyts, Johan

    2016-10-01

    Dengue virus is an emerging human pathogen that poses a huge public health burden by infecting annually about 390 million individuals of which a quarter report with clinical manifestations. Although progress has been made in understanding dengue pathogenesis, a licensed vaccine or antiviral therapy against this virus is still lacking. Treatment of patients is confined to symptomatic alleviation and supportive care. The development of dengue therapeutics thus remains of utmost importance. This review focuses on the few molecules that were evaluated in dengue virus-infected patients: balapiravir, chloroquine, lovastatin, prednisolone and celgosivir. The lessons learned from these clinical trials can be very helpful for the design of future trials for the next generation of dengue virus inhibitors. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. Clinical and laboratory factors associated with mortality in dengue.

    Science.gov (United States)

    Saroch, Atul; Arya, Vivek; Sinha, Nitin; Taneja, R S; Sahai, Pooja; Mahajan, R K

    2017-04-01

    Dengue is endemic in more than 100 countries, giving rise to an increased number of deaths in the last five years in the South-East Asian region. We report our findings from a retrospective study of adults admitted with confirmed dengue at our institution. We studied the clinical and laboratory parameters associated with mortality in these patients. Of the 172 hospitalised patients studied, 156 (90.69 %) recovered while 16 (9.3%) died. Univariate analysis showed altered sensorium on presentation, lower haemoglobin and haematocrit levels, higher serum creatinine, higher serum transaminase and lower serum albumin levels to be significantly associated with mortality in dengue. Further, using stepwise multivariate logistic regression, altered sensorium ( P = 0.006) and hypoalbuminemia ( P = 0.013) were identified as independent predictors of mortality in dengue. Identification of these parameters early in the course of disease should prompt intensification of treatment in dengue cases.

  6. Environmentally-driven ensemble forecasts of dengue fever

    Science.gov (United States)

    Yamana, T. K.; Shaman, J. L.

    2017-12-01

    Dengue fever is a mosquito-borne viral disease prevalent in the tropics and subtropics, with an estimated 2.5 billion people at risk of transmission. In many areas where dengue is found, disease transmission is seasonal but prone to high inter-annual variability with occasional severe epidemics. Predicting and preparing for periods of higher than average transmission remains a significant public health challenge. Recently, we developed a framework for forecasting dengue incidence using an dynamical model of disease transmission coupled with observational data of dengue cases using data-assimilation methods. Here, we investigate the use of environmental data to drive the disease transmission model. We produce retrospective forecasts of the timing and severity of dengue outbreaks, and quantify forecast predictive accuracy.

  7. Evidence for the Inhibition of Dengue Virus Binding in the Presence of Silver Nanoparticles

    Science.gov (United States)

    2015-03-26

    with DENV are known to increase in severity from Dengue Fever to Dengue Hemorrhagic Fever or Dengue Shock Syndrome. Currently, no vaccines or...DENV is a member of the Flavivirus family, as is the yellow fever virus (the family’s prototype), West Nile, Japanese encephalitis virus, and many...perspective/2013/10/ researchers - identify-fifth-dengue-subtype. [20] C. Moore, “UTMB Galveston Researchers Discover First New Dengue Fever Serotype In 50

  8. Nine year trends of dengue virus infection in Mumbai, Western India

    OpenAIRE

    Shastri, Jayanthi; Williamson, Manita; Vaidya, Nilima; Agrawal, Sachee; Shrivastav, Om

    2017-01-01

    Introduction: Dengue virus (DENV) causes a wide range of diseases in humans, from acute febrile illness Dengue fever (DF) to life-threatening Dengue hemorrhagic fever (DHF) or Dengue shock syndrome (DSS). Factors believed to be responsible for spread of Dengue virus infection include explosive population growth, unplanned urban overpopulation with inadequate public health systems, poor standing water and vector control, climate changes and increased international recreational, business, milit...

  9. Health System for Dengue Control : Early Case Detection and Focal Control

    OpenAIRE

    Umenai, Takusei; Nishigaki, Masaru; Osaka, Ken; Miura, Hiroko; Ishii, Katsumi

    1994-01-01

    "Aedes aegypti and dengue virus infection continue to spread in the tropical and subtropical world. Since there is no effective dengue vaccine, mosquito control and dengue patient treatment are the most important and practical way for dengue control. Many attempts have been made to control Aedes aegypti (adultcidal and larvicidal) to prevent dengue epidemic by large vertically-organized teams of workers. However, most of these methods have not been successful in the aspect of continuation of ...

  10. Molecular epidemiology of type 1 and 2 dengue viruses in Brazil from 1988 to 2001

    OpenAIRE

    Pires Neto,R.J.; Lima,D.M.; de Paula,S.O.; Lima,C.M.; Rocco,I.M.; Fonseca,B.A.L.

    2005-01-01

    Dengue is a mosquito-borne viral infection that in recent decades has become a major international public health concern. Epidemic dengue fever reemerged in Brazil in 1981. Since 1990 more than one dengue virus serotype has been circulating in this tropical country and increasing rates of dengue hemorrhagic fever and dengue shock syndrome have been detected every year. Some evidence supports the association between the introduction of a new serotype and/or genotype in a region and the appeara...

  11. Phylogenetic analysis of Dengue virus 1 isolated from South Minas Gerais, Brazil

    OpenAIRE

    Drumond, Betania Paiva; Fagundes, Luiz Gustavo da Silva; Rocha, Raissa Prado; Fumagalli, Marcilio Jorge; Araki, Carlos Shigueru; Colombo, Tatiana Elisa; Nogueira, Mauricio Lacerda; Castilho, Thiago Elias; Silveira, Nelson José Freitas da; Malaquias, Luiz Cosme Cotta; Coelho, Luiz Felipe Leomil

    2016-01-01

    Abstract Dengue is a major worldwide public health problem, especially in the tropical and subtropical regions of the world. Primary infection with a single Dengue virus serotype causes a mild, self-limiting febrile illness called dengue fever. However, a subset of patients who experience secondary infection with a different serotype can progress to a more severe form of the disease, called dengue hemorrhagic fever. The four Dengue virus serotypes (1–4) are antigenically and genetically...

  12. Factors related to severe dengue during an epidemic in Vitoria, State of Espirito Santo, Brazil, 2011

    OpenAIRE

    Vicente, Creuza Rachel; Lauar, Julia Castanheira; Santos, Bruna Silva; Cobe, Victor Marchesi; Cerutti Junior, Crispim

    2013-01-01

    Introduction The prognosis of dengue depends on early diagnosis and treatment, which can help prevent severe forms whose characteristics were evaluated here. Methods A cross-sectional study was conducted involving dengue cases in Vitória, State of Espírito Santo, Brazil, in 2011. Results Two health regions registered 56.3% of 371 cases of severe dengue. Of these cases, 21.3% presented with dengue hemorrhagic fever. There were associations between dengue hemorrhagic fever with yo...

  13. Metodología para la elaboración de canales endémicos y tendencia de la notificación del dengue, Valle del Cauca, Colombia, 2009-2013

    OpenAIRE

    Mauricio Hernández; Diana Arboleda; Stephania Arce; Allan Benavides; Paola Andrea Tejada; Sindy Vanessa Ramírez; Ángela Cubides

    2016-01-01

    Introducción. El dengue es la enfermedad de más rápida propagación en el mundo y una permanente amenaza para la salud pública mundial, con aproximadamente 2,5 millones de personas en alto riesgo de infección. Ante la gravedad del cuadro de la enfermedad a nivel nacional y mundial, es necesario generar nuevas metodologías de predicción útiles para la adopción de decisiones en salud pública. Objetivo. Caracterizar los casos notificados de dengue entre el 2009 y el 2013 en el departamento del...

  14. Metodología para la elaboración de canales endémicos y tendencia de la notificación del dengue, Valle del Cauca, Colombia, 2009-2013

    OpenAIRE

    Hernández, Mauricio; Arboleda, Diana; Arce, Stephania; Benavides, Allan; Tejada, Paola Andrea; Ramírez, Sindy Vanessa; Cubides, Ángela

    2016-01-01

    Introducción. El dengue es la enfermedad de más rápida propagación en el mundo y una permanente amenaza para la salud pública mundial, con aproximadamente 2,5 millones de personas en alto riesgo de infección. Ante la gravedad del cuadro de la enfermedad a nivel nacional y mundial, es necesario generar nuevas metodologías de predicción útiles para la adopción de decisiones en salud pública. Objetivo. Caracterizar los casos notificados de dengue entre el 2009 y el 2013 en el departamento del Va...

  15. Dengue in travellers: applicability of the 1975-1997 and the 2009 WHO classification system of dengue fever

    NARCIS (Netherlands)

    Wieten, Rosanne W.; Vlietstra, Wytze; Goorhuis, Abraham; van Vugt, Michèle; Hodiamont, Caspar J.; Leenstra, Tjalling; de Vries, Peter J.; Janssen, Saskia; van Thiel, Pieter P.; Stijnis, Kees; Grobusch, Martin P.

    2012-01-01

    Objectives The aim of this study was to assess the applicability and benefits of the new WHO dengue fever guidelines in clinical practice, for returning travellers. Methods We compared differences in specificity and sensitivity between the old and the new guidelines for diagnosing dengue and

  16. [Coexistence of acute appendicitis and dengue fever: A case report].

    Science.gov (United States)

    Osuna-Ramos, Juan Fidel; Silva-Gracia, Carlos; Maya-Vacio, Gerardo Joel; Romero-Utrilla, Alejandra; Ríos-Burgueño, Efrén Rafael; Velarde-Félix, Jesús Salvador

    2017-12-01

    Dengue is the most important human viral disease transmitted by mosquitoes. It can be asymptomatic or it can present in any of its 3clinical forms: Dengue fever, dengue haemorrhagic fever and dengue shock syndrome. However, some atypical manifestations have been reported in surgical emergencies caused by acute appendicitis in patients with dengue fever. We report the case of an 18-year-old Mexican male who presented to the emergency department of the General Hospital of Culiacan, Sinaloa, with symptoms of dengue fever, accompanied by crampy abdominal pain with positive Rovsing and Dunphy signs. Dengue infection was confirmed by a positive NS1 antigen test performed by enzyme-linked immunosorbent assay. An abdominal ultrasound revealed an appendicular process; as the abdominal pain in the right side kept increasing, an open appendectomy was performed. Abundant inflammatory liquid was observed during the surgery, and the pathology laboratory reported an oedematous appendix with fibrinopurulent plaques, which agreed with acute ulcerative appendicitis. The patient was discharged fully recovered without complications during the follow-up period. Acute abdominal pain can be caused in some cases by dengue infection. This can be confusing, which can lead to unnecessary surgical interventions, creating additional morbidities and costs for the patient. This unusual and coincident acute appendicitis with dengue highlights the importance of performing careful clinical studies for appropriate decision making, especially in dengue endemic regions during an outbreak of this disease. Copyright © 2016 Academia Mexicana de Cirugía A.C. Publicado por Masson Doyma México S.A. All rights reserved.

  17. Heterogeneidade espacial da dengue em estudos locais, Niterói, RJ Heterogeneidad espacial del dengue en estudios locales, Niteroi, Sureste de Brasil Spatial heterogeneity of dengue fever in local studies, City of Niterói, Southeastern Brazil

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    Regina Fernandes Flauzino

    2009-12-01

    Full Text Available OBJETIVO: Analisar a ocorrência espacial e temporal da dengue e sua associação com a heterogeneidade de características do ambiente urbano. MÉTODOS: Foram georreferenciados 1.212 casos de dengue registrados no Sistema de Informação de Agravos de Notificação entre 1998 e 2006, no município de Niterói, RJ, segundo setores censitários. Os setores foram classificados em áreas homogêneas para a ocorrência da doença: favela, estaleiro e urbano. Os casos foram agrupados em cinco períodos: dois interepidêmicos 1998-2000 e 2003-2005; três epidêmicos 2001, 2002 e 2006 e analisados por meio de operações entre camadas em ambiente sistema de informação geográfica. Para identificação de conglomerados com maior intensidade de casos, utilizou-se o método de kernel. O método de varredura espacial de Kulldorff foi usado para confirmação estatística desses clusters. RESULTADOS: Do total de casos, 57% eram do sexo feminino. As faixas etárias com maior concentração de casos foram de 20-29 anos (20,5% e de 30-39 anos (17,7%. O setor favela morro apresentou somente 11% dos domicílios atendidos por serviço de coleta de lixo, o maior percentual de não alfabetizados (8,7% e de chefes de família com rendimentos menores de 1 salário mínimo (29,5%. Os casos permaneceram nos setores denominados favelas. No primeiro ano epidêmico e nos períodos interepidêmicos o maior número de casos estava situado nos setores favelas morro e favela plana; no segundo e terceiro ano de epidemia, situavam-se no setor favela plana. CONCLUSÕES: A parcela economicamente ativa foi a mais atingida na área de estudo. Os setores censitários mostram heterogeneidade espacial em relação às condições de vida e dentro de alguns setores, há diferenciais na distribuição espacial e temporal do risco de ocorrência da dengue.OBJETIVO: Analizar ocurrencia espacial y temporal del dengue y su asociación con la heterogeneidad de características del ambiente

  18. Evaluation of neurological complications using who warning signs for dengue disease severity

    International Nuclear Information System (INIS)

    Akmal, A.; Tauseef, A.; Akram, T.

    2015-01-01

    In 2009 a new classification of dengue was proposed by WHO Tropical Disease Research, which classifies dengue into dengue (D), dengue with warning signs (DW) and severe dengue (SD). This classification highlights the warning signs of dengue disease severity. Neurological complications are one of the most serious complications of dengue disease. This study was carried out to see association of neurological complications of dengue patients with WHO warning signs for dengue disease severity, and their outcome. Methods: It was a cross-sectional analytical study and included 180 diagnosed and registered cases of dengue hemorrhagic fever. The participants were subjected to a detailed clinical evaluation, laboratory assessment including blood counts, hematocrit, serology for dengue fever and sonography at 24 hours and 48 hours of their admission. Results: Twenty-six percent patients were suffering from neurological complications due to dengue. The warning signs for dengue disease severity like altered sensorium (85.5%, p=0.001), raised hematocrit (n=47, p=0.029), gall bladder wall thickening, pleural effusion and ascites on sonographic report (n=47, p=0.024), were strongly associated with the neurological complications. Conclusion: Our study reveals significant association of WHO warning signs for dengue disease severity with neurological complications of dengue disease. (author)

  19. Urbanização e ecologia do dengue Urbanization and dengue ecology

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    Pedro Luiz Tauil

    2001-01-01

    Full Text Available As mudanças demográficas ocorridas nos países subdesenvolvidos, a partir dos anos 60, geradas por intenso fluxo migratório rural-urbano, resultaram em crescimento desordenado das cidades, nas quais se destacam a carência de facilidades - em particular, de habitação e saneamento básico. Cerca de 20% da população das grandes e médias cidades estão vivendo em favelas, cortiços ou em áreas de invasão. Pela falta de abastecimento de água, há necessidade de armazená-la precariamente, tal como pela ausência de destino adequado do lixo ocorre a proliferação de criadouros potenciais do Aedes aegypti, principal mosquito vetor da dengue, ou seja, depósitos improvisados para água potável e recipientes em que a água é acumulada, constituídos principalmente por latas, plásticos e garrafas usadas. A indústria moderna, por outro lado, privilegia a produção de material descartável. O vírus do dengue tem sua propagação facilitada pela intensidade e freqüência dos meios de transporte, os quais favorecem também a disseminação dos vetores da doença. Estes são alguns dos fatores que tentam explicar o ressurgimento do dengue, a mais importante arbovirose no mundo atualmente e que acomete milhares de pessoas todos os anos.Demographic changes occurring in underdeveloped countries due to intense rural-urban migration since the 1960s have resulted in overcrowded cities with multiple deficiencies, particularly in housing and basic sanitation. Some 20% of the population in large and medium-sized cities live in slums or under similar conditions. Lack of regular water supply and public garbage collection foster the proliferation of potential breeding sites for Aedes aegypti (the main mosquito vector for dengue, including precarious reservoirs for potable water and disposable recipients which accumulate water, like used cans and plastic and glass bottles. Modern industries also produce large volumes of disposable materials. Propagation

  20. Paciente VIH positivo con tuberculosis sistémica y lesiones osteolíticas de la calvaria, semejando mieloma múltiple

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    Victor Mechán

    2010-07-01

    Full Text Available Varón de 33 años, soltero, sin ocupación fija, promiscuo, con historia de relaciones homosexuales, ingesta crónica de alcohol, consumo de tabaco, marihuana, pasta básica y clorhidrato de cocaína, desde los 18 años. Infectado por el virus de la inmunodeficiencia humana, recibía tratamiento irregular con terapia antirretroviral de gran actividad (Targa entre 2006 y 2008, regularizada en los últimos 12 meses. Por presentar bacilo ácido alcohol resistente (BAAR pansensible en esputo, inició en junio 2008 tratamiento antituberculoso [2RHZE/4(HR2], retirándosele la medicación 6 meses después por presentar BAAR pulmonar negativo. En marzo de 2009, percibió dolor lumbar intenso, dificultad para caminar, hipertrofia de ganglios cervicales, tos, fiebre. Un cultivo de secreción ganglionar cervical descubrió