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Sample records for con epilepsia focal

  1. Epilepsia de la infancia con paroxismos occipitales

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    Albia Pozo Alonso

    1999-09-01

    Full Text Available Se reporta que la epilepsia de la infancia con paroxismos occipitales constituye un síndrome epiléptico muy bien definido; se incluye en el grupo de las epilepsias idiopáticas relacionadas con localización. Los ataques comienzan habitualmente con síntomas visuales, en ocasiones seguidos por ataques hemiclónicos, parciales complejos y tónicoclónicos generalizados. El electroencefalograma interictal muestra complejos de puntaonda de localización occipital y temporal posterior que desaparecen con la apertura de los ojos. Se presenta una paciente de 8 años de edad que reúne los criterios clínicos y electroencefalográficos de la epilepsia de la infancia con paroxismos occipitales y se enfatiza en la evolución supuestamente benigna de dicho síndrome.Is is reported that epilepsy of childhood with occipital paroxysms is an epileptic syndrome that is well defined. It is included in the group of related idiopathic epilepsies with localization. Seizures habitually begin with visual symptoms, which are ocassionally followed by hemiclonic, complex partial, and generalized tonicclonic seizures. The interictal EEG shows spike-wave complexes of occipital and temporal posterior localization that are suppressed by eye opening. A patient aged 8 in whom the clinical and electroencephalographic criteria of epilepsy of childhood with occipital paroxysms are present is studied in this paper. Emphasis is made on the apparently benign evolution of this syndrome.

  2. Relación entre electroencefalograma y neuroimagen en niños con epilepsia focal de difícil control Relation between electroencephalogram and neuroimaging present in children with epilepsy of difficult control

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    Ileana Valdivia Álvarez

    2009-09-01

    Full Text Available INTRODUCCIÓN. Las epilepsias focales son las más frecuentes en los niños, y la resistencia al tratamiento farmacológico puede estar presente hasta en el 30 % de los pacientes. Se realizó este estudio con el objetivo de dirigir la atención hacia la coincidencia topográfica de los paroxismos electroencefalográficos, con lesiones estructurales demostrables por neuroimagen, para facilitar el diseño de estrategias terapéuticas futuras. MÉTODOS. Se realizó un estudio descriptivo, longitudinal prospectivo, con 44 niños con diagnóstico de epilepsia focal de difícil control, ingresados en el Servicio de Neuropediatría del Hospital Pediátrico Docente «Juan M. Márquez», entre enero de 2003 y junio de 2007. Se realizaron estudios por electroencefalograma (EEG al ingreso y videoelectroencefalograma, además de estudios de neuroimagen por tomografía axial o resonancia magnética nuclear. RESULTADOS. Los paroxismos en EEG involucraron el lóbulo frontal hasta en el 68 % de los pacientes. En el 48 % de los pacientes, los paroxismos electroencefalográficos coinciden con zonas de alteración estructural según neuroimagen, más frecuentes en el lóbulo frontal. En el 25 % no hay coincidencia topográfica y en el 27 % no se precisan alteraciones estructurales. CONCLUSIONES. En las epilepsias focales de difícil control se debe prestar especial atención a las zonas elocuentes con coincidencia entre el EEG y la neuroimagen, para evaluar de forma temprana las alternativas quirúrgicas de tratamiento.INTRODUCTION: Focal epilepsies are the more frequent conditions in children and a pharmacologic treatment resistance could be present up to 30% of patients. Aim of present paper was to direct the attention to topographic coincidence of electroencephalographic paroxysms with structural lesions by neuroimaging facilitating the future therapeutical strategies design. METHODS: A descriptive, longitudinal, prospective study was conducted in 44 children

  3. TUMORES CEREBRALES ASOCIADOS A EPILEPSIA

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    Dr. Manuel G. Campos

    2017-05-01

    La Resonancia Magnética de cerebro es mandatoria en el estudio de todo paciente con epilepsia, para detectar lesiones estructurales, especialmente en epilepsia focal. Alrededor del 30% de los pacientes operados de epilepsia refractaria presentan tumores. En estos casos el control de crisis post-operatorio llega hasta un 70% en el seguimiento a largo plazo.

  4. Comorbilidad del trastorno compulsivo en pacientes con epilepsia

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    ÁVILA AVILES,JOSÉ MANUEL

    2004-01-01

    Aunque la mayoría de los pacientes con epilepsia tienen una vida normal, pero problemas neuroconductuales se presentan en un número importante de pacientes y pueden ser síntomas aislados o un verdadero trastorno psiquiátrico. Por esta razón pueden presentarse diagnósticos erróneos de trastorno psiquiátrico o epilepsia. También algunos medicamentos antiepilépticos pueden causar trastorno psiquiátrico. Al menos cinco millones de personas en Latinoamérica sufren de epilepsia y tres millones no r...

  5. Agnosia integrativa causada por una epilepsia focal occipital izquierda: estudio de caso

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    Óscar Mauricio Aguilar Mejía

    2011-01-01

    Full Text Available La agnosia integrativa es un tipo de agnosia visual asociada a lesiones occipitales bilaterales que se caracteriza por la incapacidad para identificar estímulos en fondos complejos, especialmente, cuando se trata de formas superpuestas o entrelazadas. Existen dificultades para codificar y agrupar el todo a partir de las partes del estímulo. Se presenta un caso de una paciente de 14 años, con una agnosia integrativa como consecuencia de una epilepsia focal sintomática refractaria, con un foco epileptogénico occipital izquierdo. Se plantean las características clínicas de la paciente y se hace un análisis de sus procesos de reconocimiento visual discutidos a partir de los diferentes modelos teóricos que tratan de explicar la percepción visual.

  6. Experiencia con la dieta cetogénica como tratamiento en la epilepsia refractaria

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    Ramírez Camacho, Alia; Meavilla, Silvia; Catalán, Natalia; Gutiérrez, Alejandra; Campistol Plana, Jaume

    2011-01-01

    Introducción: La epilepsia es una enfermedad neurológica que se controla con fármacos antiepilépticos en la mayoría de casos. Sin embargo, aproximadamente un 25% de epilepsias son refractarias al tratamiento farmacológico. La dieta cetogénica es una de las opciones terapéuticas para este tipo de epilepsia. A pesar del aumento en los últimos años de la popularidad de ésta como tratamiento anticonvulsivo, no se ha establecido un consenso internacional para sus indicaciones y manejo. Objetivo: E...

  7. La Famiempresa, una Opción de Vida para Pacientes con epilepsia y retardo mental

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    Gladys María Carrascal Navarro

    2014-04-01

    Full Text Available La rehabilitación integral de personas que padecen epilepsia basada en la investigación individualizada de fallas cognitivas, del lenguaje y la relación con las funciones neuropsicológicas de las zonas del cerebro comprometidas ha sido, y es, la función científica y social de la Fundación Instituto de Rehabilitación para personas con Epilepsia “FIRE”. Desde el marco de la Educación Especial, en el 2007 el FIRE creó un programa el cual es llamado Famiempresa, como una opción de vida para los pacientes alumnos con epilepsia y/o cirugía de epilepsia y retardo mental, Población con alto grado de vulnerabilidad. Este programa es, sin duda alguna, un modelo para otras instituciones que trabajan con personas con discapacidad. Se pretende mostrar en este documento las bondades de este proyecto y los resultados obtenidos desde su creación para beneficio de sus pacientes alumnos.

  8. Función Ejecutiva y Electroencefalografía en tres grupos de pacientes pediátricos con diagnóstico de epilepsia

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    Francisco Cabrera-Portieles

    2014-04-01

    Full Text Available Introducción: En niños con epilepsia, las alteraciones de las funciones ejecutivas están relacionadas con variables propias de la enfermedad como son la edad de inicio de las crisis, la frecuencia de las mismas y la duración evolutiva del cuadro asociado al uso de fármacos. Objetivos: Comparar los hallazgos en la actividad electroencefalográfíca y alteraciones de las funciones ejecutivas en 3 grupos de pacientes pediátricos con diagnóstico de epilepsia. Métodos: Se evaluaron trazados EEG y funciones ejecutivas con (Trail Making Test parte B, FAS fonológico y Prueba de Wisconsin, en 29 pacientes entre 8 y 14 años con diagnóstico de epilepsia divididos en 3 subgrupos (No medicados, Monoterapia y Politerapia. Resultados: De 29 pacientes estudiados, 8 masculinos (62.1% y 11 femeninos (37.9%, edad promedio de inicio de crisis fue 6.59 años, duración promedio de la enfermedad de 4.59 años; se encontraron hallazgos patológicos de tipo focal en los registros EEG de 21 pacientes de los 3 subgrupos (72.4%, con área paroxística frontal en 11 pacientes (37.9% y temporal en 6 pacientes (20.7%. En 16 pacientes encontramos pobre organización de la actividad de base (55.2%. La media total para el FAS fonológico fue de 15.7 ± 6.96 al comparar los grupos con la población general (P= 0.003*.En los grupos de pacientes la media en tiempo para el TMT parte B fue de 92.90 (DE ± 28.91 vs 77.70 (DE ± 23.8 de la población general, encontrándose dentro de los límites normales. En el Test de Wisconsin existen alteraciones a nivel de ejecución en diferentes categorías en niños con epilepsia al ser comparados con la población general (Fallas para mantener el principio p=0.045*. Conclusiones: Las alteraciones de las funciones ejecutivas en pacientes con diagnóstico de epilepsia sugieren la necesidad de realizar estudios neuropsicológicos y electroencefalografícos de manera periódica; con el fi n de evaluar actividad interictal epileptiforme

  9. Aspectos clínicos y electroencefalográficos de la epilepsia focal en el niño Clinical and electroencephalographic features of focal epilepsy present in children

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    Albia Pozo Alonso

    2009-06-01

    Full Text Available INTRODUCCIÓN. El objetivo del presente trabajo fue caracterizar un grupo de pacientes con epilepsias focales, según aspectos clínicos y electroencefalográficos. MÉTODOS. Se realizó un estudio descriptivo y prospectivo de 185 niños con diagnóstico de epilepsia focal (2 o más crisis epilépticas no provocadas, con edades entre un mes y 14 años, que fueron hospitalizados en el Departamento de Neuropediatría del Hospital «William Soler» entre diciembre de 2001 y diciembre de 2003. RESULTADOS. La edad media de inicio de la primera crisis epiléptica fue de 5 años. El tipo de crisis epiléptica focal más frecuente fue la simple (49,2 %. El 48,6 % de los niños presentó etiología idiopática y el 33,0 % sintomática. Los factores de la etiología sintomática más frecuentes fueron los prenatales (56,2 %. El 91,4 % de los pacientes presentó electroencefalogramas iniciales interictales anormales. El electroencefalograma focal se observó en el 37,3 % de los niños y el multifocal en el 24,9 %. El síndrome epiléptico más frecuente fue la epilepsia benigna con puntas centrotemporales (5,9 %. CONCLUSIONES. Los niños con epilepsia focal tienen variadas manifestaciones clínicas y electroencefalográficas, y en la mayoría de los pacientes no es posible identificar un síndrome epiléptico.INTRODUCTION: The aim of present paper was to characterize a group of patients presenting with focal epilepsies by clinical and electroencephalographic features. METHODS: Authors made a descriptive and cross-sectional study in 185 children diagnosed with focal epilepsy (two or more non-provoked epilepsy crises, aged from one month to 14, admitted in Neurology Department of "William Soler" Children Hospital between December 2001 to December 2003. RESULTS: Mean age of the first epilepsy crisis was at 5 years. The more frequent type of focal epilepsy crisis was the simple one (49, 2%. The 48, 6% of children presented with a idiopathic origin, and the 33

  10. ¿Migraña o epilepsia? Cómo identificar y diferenciar las epilepsias occipitales

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    Andrés Castaño Parra

    2005-02-01

    Full Text Available Las epilepsias focales idiopáticas de la infancia constituyen el 30-35% de todas las epilepsias en el rango de edad de 2 a 10 años. La más frecuente de todas es la epilepsia benigna de la infancia con espigas centrotemporales, denominada también Rolándica. En segundo lugar se encuentran las epilepsias occipitales que, aunque son relativamente infrecuentes, se deben conocer para hacer el diagnóstico y diferenciarlas de otras entidades más frecuentes como la migraña con aura. Entre las epilepsias occipitales se deben diferenciar las formas .sintomáticas. (que tienen causas conocidas de las idiopáticas (genéticas. En las primeras se logra demostrar una lesión estructural en el sistema nervioso central (SNC que puede explicar la epilepsia. Las epilepsias idiopáticas occipitales benignas de la infancia se dividen de acuerdo con la edad de inicio, el cual puede ser temprano, conocida también como tipo Panayiotopoulos, o tardío, también denominada tipo Gastaut. Hay una tercera forma de epilepsia idiopática aún no aceptada por muchos autores, la cual es una combinación de las dos anteriores, con un patrón electroencefalográfico específico. La migraña con aura presenta algunas características que permiten al clínico diferenciarla de las epilepsias occipitales.

  11. Sistema de planificación para la colocación de electrodos profundos cerebrales en la evaluación prequirúrgica de la epilepsia focal mediante estereoelectroencefalografía

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    Cabrera Parra, Walter

    2016-01-01

    La epilepsia es una enfermedad cerebral crónica que se caracteriza por convulsiones recurrentes originadas por descargas eléctricas de neuronas ubicadas en zonas o estructuras situadas en las láminas de la corteza cerebral. La resección, ablación quirúrgica o radiocirugía es una opción para la epilepsia focal fármaco-resistente. La localización de la estructura o zona epileptógena (ZE) en la epilepsia focal es crucial en el contexto de la cirugía de la epilepsia. La estéreoelectroencefalograf...

  12. Calidad de vida y entorno escolar del niño con epilepsia

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    Yanquiel Barrios-Hernández

    2013-01-01

    Full Text Available El concepto de calidad de vida es un término que designa un tema de gran interés y trascendencia para el ser humano actual y futuro. El hecho de padecer una enfermedad crónica no transmisible como la epilepsia, de una forma u otra interviene en la calidad de vida de las personas. El presente artículo tiene como objetivo explicar la influencia que ejerce la enfermedad sobre la calidad de vida cuando es padecida por infantes de edad escolar. Además se pretende demostrar cómo inciden los factores familiar y escolar en la calidad de vida de la población infante con epilepsia. Las personas profesionales de la enseñanza juegan un rol esencial en este afán de que el infante no sea degradado por el medio en el que se desenvuelve, la explicación de esta afirmación resulta otra de las aspiraciones que se tiene con este artículo.

  13. Neuroimagen en niños con epilepsia de difícil control Children with epilepsy of difficult control: Neuroimaging

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    Ileana Valdivia Álvarez

    2009-09-01

    Full Text Available INTRODUCCIÓN. Los actuales estudios de neuroimagen representan un gran avance para el diagnóstico etiológico y pronóstico de la epilepsia infantil. El objetivo del presente estudio fue describir los hallazgos por tomografía axial y resonancia magnética en niños con epilepsias de difícil control y comparar los resultados de estas técnicas. MÉTODOS. Se realizó un estudio descriptivo, longitudinal prospectivo, de 108 niños con diagnóstico de epilepsia de difícil control, ingresados en el Servicio de Neuropediatría del Hospital Pediátrico Docente «Juan Manuel Márquez» entre enero de 2002 y junio de 2006. Se realizaron técnicas imagenológicas por tomografía computarizada (TC y resonancia magnética nuclear (RM. RESULTADOS. Se encontraron alteraciones estructurales del cerebro en el 88 % de los niños, y hubo predominio de lesiones prenatales en la fosa posterior, trastornos de la migración y atrofias secundarias a hipoxia perinatal. Se diagnosticó atrofia cortical localizada, mediante RM, hasta en el 28 % de los niños. CONCLUSIONES. La RM es la técnica de elección para el estudio de pacientes con epilepsia de difícil control, por su especificidad, mayor resolución y relativa inocuidad. Los pacientes con zonas localizadas de atrofia requieren estudios funcionales del cerebro para descartar displasias corticales focales.INTRODUCTION: Current studies of Neuroimaging are a great advance to etiologic and prognostic diagnosis of children epilepsy. The aim of present paper was to describe findings by axial tomography (AT and magnetic resonance (MR in children with epilepsy of difficult control, and to compare results of both techniques. METHODS: A descriptive, longitudinal and prospective study was made in 108 children diagnosed with epilepsy of difficult control, admitted in Neuropediatrics Service of "Juán Manual Márquez" Teaching Children Hospital from January, 2002 to June, 2006. The techniques used were: computed

  14. Epilepsia y mujer

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    S. Andrea Contreras, Dra.

    2013-11-01

    Full Text Available Hay muchos aspectos por abordar en el manejo de las mujeres con epilepsia, relacionados con su rol en la reproducción. Algunos de éstos necesitan ser considerados en la adolescencia, otros están relacionados con el embarazo, afectando tanto a la madre como a su hijo, y algunos con el ciclo menstrual y la menopausia. Esta revisión considera la epilepsia catamenial, contracepción, fertilidad, teratogenicidad y menopausia. También se discuten los efectos del embarazo en el control de las crisis y los efectos de las crisis sobre el feto.

  15. Crisis febriles simples y complejas, epilepsia generalizada con crisis febriles plus, FIRES y nuevos síndromes

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    Noris Moreno de Flagge

    2013-09-01

    Full Text Available Las convulsiones febriles representan la mayoría de las convulsiones en el niño. Se ha descrito que 2-5% de los niños experimentan convulsiones febriles antes de los 5 años de edad, aunque en algunas poblaciones se ha descrito hasta un 15%. Es una causa común de admisión en pediatría y de preocupación de los padres. Puede ser la primera manifestación de una epilepsia. Un 13% de pacientes que desarrollan epilepsia tienen antecedente de convulsiones febriles y 30% de estos pacientes se presentan con convulsiones recurrentes. Sus características fenotípicas nos permiten, en su gran mayoría, clasificarlas, tomar una actitud terapéutica y elaborar un pronóstico. Se puede describir un espectro de su gravedad desde las convulsiones febriles simples hasta las más complejas como las convulsiones febriles plus que comprenden los síndromes de Dravet y FIRES. En los últimos años se han hecho descubrimientos importantes que definen su carácter genético, entrelazándose cada vez más con diferentes afecciones de tipo epiléptico que nos obliga a un seguimiento neurológico más estrecho de muchos de estos niños con convulsiones febriles. Hacemos una revisión bibliográfica con el objetivo de actualizar los conocimientos sobre las convulsiones febriles, su pronóstico y su relación con los nuevos síndromes epilépticos.

  16. Frecuencia de Síntomas de Depresión en Pacientes Adolescentes con Epilepsia. Tratados en el Servicio de Consulta Externa de la Fundación Hospital de la Misericordia y Fundación Liga Central Contra La Epilepsia

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    Carolina Ñungo

    2009-07-01

    Full Text Available

    *Este artículo está basado en la tesis de especialización de Carolina Ñungo bajo la dirección del segundo y tercer autor. Fragmentos de este artículo fueron presentados como poster en el XIV Congreso Nacional de Epilepsia en Medellín, Colombia, Septiembre de 2008.

    Resumen

    La epilepsia es una condición neurológica crónica que debido a su etiología, mecanismo fisiopatológico, a la clínica y al tratamiento tiene importantes repercusiones en el estado biopsicosocial de las personas que la padecen. En las últimas décadas se ha llamado la atención hacia el deterioro mental, emocional y en general en la calidad de vida de estos pacientes al padecer diferentes trastornos psicológicos. El tipo de comorbilidad psiquiátrica que con mayor frecuencia se diagnóstica en los pacientes con epilepsia es el trastorno depresivo.

    Este estudio permite demostrar que la frecuencia de síntomas de depresión en un grupo de adolescentes entre 13 y 17 años con epilepsia es 4 veces mayor al compararlos con un grupo de personas de la misma edad sin epilepsia. Además el padecer epilepsia es el factor de asociación más importante para presentar síntomas depresivos de forma independiente con respecto a la edad o estrato socioeconómico.

    Debido al tamaño de la muestra (90 pacientes no se pudieron encontrar diferencias estadísticamente significativas con respecto a los distintos tipos de epilepsia, su evolución y tratamiento, aunque se hallo una mayor tendencia a la depresión en aquellos pacientes con diferentes tipos de crisis (focales y generalizadas, con epilepsia mal controlada y los que requieren politerapia.

    Este el primer estudio en adolescentes realizado en nuestro país que demuestra la relevancia que tiene este tipo de trastornos en nuestros pacientes como se había demostrado en otros estudios a nivel mundial.

    Palabras clave Síntomas depresivos

  17. Análisis del Perfil Cardiovascular en Niños y Adolescentes con epilepsia idiopática

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    Randy Guerra-Olivares

    2014-04-01

    Full Text Available Introducción: El uso apropiado de ácido valproico y carbamazepina ha mostrado marcada eficacia para el control de las crisis en pacientes con diagnostico de epilepsia; sin embargo, se ha visto asociado a ciertos efectos secundarios. Entre ellos, cobran especial importancia aquellos que afectan el peso corporal y el perfil bioquímico. Objetivo: Evaluar la presencia de factores de riesgo cardiovasculares en niños y adolescentes diagnosticados con epilepsia idiopática, tratados en monoterapia con ácido valproico o carbamazepina. Métodos: Estudio analítico de corte transversal en niños y adolescentes con diagnóstico de epilepsia en monoterapia con alguna de las dos drogas mencionadas, a quienes se les realizó toma de medidas antropométricas como peso y talla, se calculó índice de masa corporal y se tomaron muestras de sangre para realizar cuantificación en suero de la droga, glucemia y perfiles lipídicos. Resultados: Del total de 30 pacientes, 14 fueron medicados con ácido valproico y 16 con carbamazepina, edad promedio del primer grupo, 9,4 años (IC95% 7,0 a 10,9, 50 % género masculino; (IC95% 26,8 a 73,2 recibiendo dosis promedio de de 26,8 mg/kg/día. Grupo carbamazepina, con edades promedio de 10,3 años (IC95% 8,8 a 11,8, 9 pacientes masculinos (56,3 %; IC95% 33,2 a 76,9 y 7 femeninos (43,7 %; IC95% 23,1 a 66,8, recibiendo dosis promedio de 14,1 mg/kg/día (IC95% 12,6-15.7; mínimo 8,8 y máximo 21,3. Del total de niños 26,7 % presentaban retardo de crecimiento y el 73,3 % normalidad. Todos los casos tuvieron glucemias menores de 100 mg/dL y triglicéridos mayores de 100 mg/dL. En el grupo de carbamazepina, 75% presentaban hipercolesterolemia (≥ 170 mg/dL superior al grupo ácido valproico (21,4 %; 3/14; con diferencia de proporciones (IC95% 18 a 74 %; p = 0,003*. Conclusiones: Los resultados obtenidos sugieren que es necesario considerar las alteraciones del perfi l lipídico en relación del tratamiento con cualquiera de

  18. Factores pronósticos de recurrencia de la epilepsia focal en el niño Prognostic factors of recurrence of focal epilepsy in children

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    Albia Pozo Alonso

    2009-12-01

    Full Text Available INTRODUCCIÓN. El objetivo de este trabajo fue determinar los factores pronósticos de recurrencia de las crisis epilépticas focales a los 2 años del diagnóstico y del inicio del tratamiento. MÉTODOS. Este estudio observacional, analítico y prospectivo incluyó a 207 niños que presentaron dos o más crisis epilépticas focales no provocadas, hospitalizados en el Departamento de Neuropediatría del Hospital «William Soler», entre diciembre de 2001 y diciembre de 2003. Al final de los 2 años de seguimiento, 185 pacientes concluyeron el estudio. RESULTADOS. El 33,5 % de los pacientes presentó recurrencias de las crisis epilépticas focales al finalizar el estudio. Constituyeron factores de riesgo de recurrencia de las crisis epilépticas focales los siguientes: edad menor de un año, etiología sintomática, presencia de antecedentes personales de crisis neonatales sintomáticas y discapacidades neurológicas y la persistencia de descargas en el electroencefalograma (EEG evolutivo. El análisis de regresión logística demostró como variables pronósticas de recurrencia la etiología sintomática (p = 0,000; OR = 3,107, el antecedente personal de crisis neonatales sintomáticas (p = 0,037; OR = 4,623 y la persistencia de descargas en el EEG evolutivo (p = 0,000; OR = 2,109. CONCLUSIONES. El antecedente personal de crisis neonatales sintomáticas constituyó el factor independiente con mayor influencia en las recurrencias de las crisis epilépticas focales.INTRODUCTION: The objective of present paper was to determine the recurrent prognostic factors of focal epileptic crises at 2 years of diagnosis and of treatment onset. METHODS: This prospective, analytical and observational study included 207 children presenting two or more non-provoked epileptic crises, admitted in Neuropediatrics Department of "William Soler" Hospital between December, 2001 and December, 2003. At a two years follow-up, 185 patients concluded the study. RESULTS: The

  19. TUMORES CEREBRALES ASOCIADOS A EPILEPSIA

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    Dr. Manuel G. Campos

    2017-01-01

    Entre el 20 a 40% de los tumores cerebrales pueden manifestarse primariamente con crisis epilépticas y un 20 a 45% pueden presentar epilepsia durante el curso de la enfermedad. Las crisis pueden ser causadas por el compromiso cortical tumoral, así como en áreas distantes por deaferentación. Las crisis pueden responder a fármacos antiepilépticos o presentarse como epilepsia refractaria a fármacos. Los tumores de más lento crecimiento se asocian a epilepsia de largo tiempo de evolución, pero ha...

  20. Correlación entre la memoria subjetiva y objetiva episódica en pacientes con epilepsia del lóbulo temporal medial intratable

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    Marilyn Zaldivar Bermúdez; Lilia María Morales Chacón; Otto Trápaga Quincoses; María García Navarro; Abel Sánchez Curuneaux

    2013-01-01

    Introducción. En la literatura científica revisada prevalece una discordancia en las investigaciones sobre la relación entre la memoria subjetiva y objetiva en pacientes con Epilepsia del Lóbulo Temporal medial intratable (ELTmi). Objetivo. Identificar la existencia o no de relación entre la memoria subjetiva y objetiva episódica en pacientes con ELTmi. Metodología. Se estudiaron 32 pacientes, con edades entre 15 y 60 años, empleándose el método clínico. Se aplicó una entrevista semiestructur...

  1. LA DISCRIMINACIÓN Y ESTIGMATIZACIÓN A LAS PERSONAS CON EPILEPSIA. SUS DERECHOS HUMANOS Y CIVILES. Ley antidiscriminatoria en Colombia

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    Jaime Fandiño-Franky

    2010-06-01

    Full Text Available

    Resumen

    Se hace un recuento histórico de la discriminación y estigmatización de las personas con epilepsia desde 500 años antes de Cristo hasta nuestros días. Se enfatiza en la situación de Colombia y se explica en qué consiste el proyecto de ley que se halla para el estudio de la Corte Constitucional. Es un proyecto que básicamente propende por la educación masiva al pueblo colombiano sobre la epilepsia y protege a las personas con epilepsias de la discriminación en todos los actos de su vida, sin desconocer la invalidez que produce.

    Palabras clave: Epilepsia, discriminación, educación.

    Abstract

    We describe the situation of people with epilepsy through the times, from fi fth century B.C. until today. The anti-discriminatory law project that was approved by the Colombian Parliament is now in the Constitutional Court and propends for the human rights and appropriate medical attention for them.

    Key words: Epilepsy, Discrimination, Education. “Nacemos libres e iguales en dignidad y derechos, dotados de razón y conciencia. Debemos comportarnos fraternalmente”. “Derecho a la seguridad social, al trabajo, a la educación”. (Declaración Universal de los Derechos Humanos. (1

  2. Caracterización de Los Problemas de Aprendizaje en Niños y Adolescentes con Epilepsia Primaria Generalizada en La Liga Central contra la Epilepsia y El Hospital de la Misericordia (Bogotá, Colombia*

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    Lina Marcela Tavera Saldaña

    2011-10-01

    Full Text Available

    * Trabajo ganador del Premio Nacional a la Investigación e Epilepsia Margaret Merz de Fandiño 2011. 

    RESUMEN

    Objetivo: Determinar la prevalencia de los trastornos específicos del aprendizaje (TEA en una serie de pacientes con epilepsia primaria generalizada.

    Materiales y Métodos: Con dicho diagnóstico se estudió un grupo de 32 niños y adolescentes entre 7 y 17 años, a quienes se les realizó una evaluación neuropsicológica con énfasis en habilidades escolares (lecto-escritura y cálculo.

    Resultados: Se encontró que la frecuencia de problemas de aprendizaje en la población epiléptica estudiada fue del 34,38%. Además, se observó una prevalencia de 40,63% de problemas de atención siendo la atención, esta última y la velocidad de procesamiento las variables neuropsicológicas que más se vieron afectadas.

    Conclusión: Es importante reconocer que los TEA son una comorbilidad frecuente en pacientes con epilepsia, se asocian con una alta tasa de fracaso y deserción escolar. En el grupo de pacientes valorados se observó una frecuencia de TEA más alta que la informada en la población general.

    Palabras clave: ENI (Evaluación Neuropsicológica Infantil, epilepsia primaria generalizada, trastornos de aprendizaje, trastornos de lectoescritura, trastornos del cálculo.

    ABSTRACT

    Specific Learning Disorders in Children And Adolescents With Generalized Primary Epilepsy Seen At Central League Against Epilepsy and at Mercy Hospital (Bogota, Colombia 

    Objective:To establish the prevalence of specific learning disorders (SLD in a series of patients with primary generalized epilepsy.

    Materials and Methods: A group of 32 children and adolescents aged 7 to 17 years with above mentioned diagnosis underwent neuropsychological evaluation with emphasis on academic skills (reading, writing

  3. Diagnostic methods for extra-temporal neocortical focal epilepsies: present and future Métodos diagnósticos das epilepsias focais neocorticais extratemporais: presente e futuro

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    Ricardo André Amorim Leite

    2010-02-01

    Full Text Available The progress of epilepsies diagnosis has been great, but, amongst the diagnostic detailing that demand research, one of the most important is the essential lateralization and localization of epileptogenic zone, considered as the cerebral cortex region, that removed, will result in a free state of seizures. The present study aims to analyze the possible uses of proton spectroscopy for clinical and pre-surgical evaluation of focal extratemporal epilepsies, since this group presents the highest difficulty degree for lateralizing and locating epileptogenic zones. In almost all cases, a non invasive diagnosis can be performed using routine electroencephalography, video-electroencephalography - considered as gold standard, and magnetic resonance imaging. However, when the results of these exams are contradictory, some patients need invasive techniques, as the intra-cranial video-EEG, using deep electrodes, sub-dural strip and grid, that are associated with increased diagnostic cost and risk of complications, as cerebral hemorrhages and intra-cranial infections. Proton spectroscopy appears as a possibility, given its capacity to evaluate cerebral metabolism, by N-acetyl-aspartate (NAA, creatine (Cre and choline (Cho concentrations, amongst other metabolites. This non invasive method may provide time reduction of this evaluation and reliable level improvement for this topographical diagnosis.Tem sido grande o progresso no diagnóstico das epilepsias, mas dentre os detalhamentos diagnósticos a exigir pesquisas, estão a lateralização e a localização precisas da zona epileptogênica, considerada como a região do córtex cerebral que, removida, irá resultar num estado livre de crises. Por meio de revisão da literatura, o objetivo deste estudo é expor e analisar os métodos diagnósticos das epilepsias neocorticais extratemporais, dadas as características que as tornam mais complexas do que as epilepsias temporais visto que estas apresentam o

  4. Calidad de vida relacionada con la salud y trabajo en la epilepsia

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    Beatriz C. Thomann Rey

    Full Text Available Introducción: En la monitorización de salud de la población, a medida que se controla la mortalidad prematura, van ganando terreno los indicadores de "Calidad de Vida" en detrimento de los "Cantidad de Salud". Los instrumentos de medida de Calidad de Vida Relacionados con la Salud (CVRS, pueden ayudar a valorar la aptitud de los trabajadores epilépticos. Objetivo: Observar si la empleabilidad influye en la CVRS de los pacientes epilépticos, y como están afectados los dominios de sensación energía/fatiga y funciones cognitivas, con el cuestionario QOLIE-31. Metodología: Búsqueda bibliográfica utilizando las bases de datos PubMed, Scielo, IBECS, Cochrane Plus, Google Académico y LILACS. El nivel de evidencia se estableció de acuerdo a los criterios de SIGN. Resultados: Se seleccionaron 10 artículos, de 244 artículos recuperados. De ellos, seis son estudios transversales y solo uno obtiene asociación estadísticamente significativa, p<0,001, en el análisis de regresión multivariante, entre trabajo y total QOLIE-31. De los otros cuatro, de validación, tres obtienen asociación estadísticamente significativa con p<0.001, p<0.0001 y p=0,0002, pero solo en el análisis univariante. Variables explicativas con mayor valor predictivo en los dominios de sensación de energía/fatiga y función cognitiva fueron: la frecuencia de las crisis y los síntomas depresivos. Conclusión: No se puede concluir que los epilépticos que trabajan tienen una mejor CVRS que los que no trabajan. Existen sesgos importantes de selección e información, además de diferencias culturales y sociales. Medidas de CVRS podrían ayudar, a la hora de valorar la aptitud de los enfermos epilépticos en el trabajo.

  5. Tegretol no tratamento da epilepsia

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    Jorge Armbrust-Figueiredo

    1968-09-01

    Full Text Available O Tegretol (5-carbamil-5H-dibenzo-b,L-azepina foi usado no tratamento de 68 pacientes com epilepsia; 54 apresentavam epilepsia temporal (42 com crises psicomotoras e 12 com crises complexas, 11 epilepsia focal de projeção não temporal e 3 epilepsia centrencefálica com crises P.M. Resultados satisfatórios foram observados em 82% dos 65 pacientes com epilepsia focal; os 3 pacientes com crises P.M. não foram influenciados pelo tratamento. A ação sobre as manifestações psíquicas que acompanhavam o quadro crítico ou intercrítico das crises ficou bem evidenciada. Os pacientes melhoraram de seus sintomas na grande maioria dos casos, conseguindo adaptar-se melhor no ambiente familiar, profissional e escolar. O efeito sobre as alterações eletrencefalográficas é moderado, e a evolução clínica não acompanha as modificações dos traçados. As doses usadas, em geral de 400 a 600 mg diários, são suficientes para o controle das crises na maioria dos casos e estão muito abaixo dos limites considerados como de segurança. As reações secundárias foram observadas em pequeno número de casos e foram sempre transitórias. O Tegretol representa, em nossa opinião, recurso de valor no trataemnto das epilepsias focais, particularmente nas crises psicomotoras.

  6. Epilepsia de Lafora

    OpenAIRE

    Núñez D, Carolina; Elso T, María José; Armijo M, José; Ramírez C, Darío; Cartier R, Luis

    2008-01-01

    Clínicamente, la enfermedad de Lafora es una forma de epilepsia mioclónica progresiva, autosómica recesiva. Se desarrolla debido a la mutación del gen que codifica para la laforina y/o la malina, las cuales están involucradas en la regulación del metabolismo del glicógeno. Los corpúsculos de Lafora que identifican la enfermedad están compuestos por agregados densos de poliglicano que se encuentran en inclusiones tanto en el cerebro, como en otros tejidos. Describimos una mujer de 18 años con ...

  7. Presentación del Libro, “Epilepsia. Aspectos Clínicos y Psicosociales”.

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    Carlos Medina Malo

    2006-12-01

    aspectos biológicos. Es excelente porque muestra el equipo que reunió el Dr. Medina, a los integrantes de la Liga contra la Epilepsia, que se ve reflejada en ese aspecto biopsicosocial de la persona con epilepsia.

  8. Menstrual cycle worsening of epileptic seizures in women with symptomatic focal epilepsy Piora de crises epilépticas durante o período menstrual em mulheres com epilepsia focal sintomática

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    Ana Carolina Belini Bazán

    2005-09-01

    Full Text Available INTRODUCTION: Hormonal fluctuation is responsible for worsening of epileptic seizures during the menstrual cycle. OBJETIVE: To identify irregularities in the menstrual cycles of women with mesial temporal lobe epilepsy (MTLE and extratemporal focal epilepsy (ETFE and correlate the frequency of seizures during the menstrual cycles. METHOD: We evaluated prospectively women in the menacme with MTLE and ETFE. Calendars were provided for these patients, and they were asked to mark their seizure frequency according to the menses. Calendars were reviewed in each routine medical appointment. RESULTS: Thirty-nine patients with MTLE and 14 with ETFE were evaluated. We registered 211 cycles in the patients with MTLE and 49 in those with ETFE. Irregular menstrual cycles were found in 28 (28/39, 71.7% patients with MTLE and 6 (6/14, 42.8% with ETFE (p=0.052. Premenstrual seizure worsening was observed in 46 (21.8% patients with MTLE and 9 (18.3% with ETFE (p=0.596. Menstrual worsening was observed in 47 (22.2% patients with MTLE and 15 (30.6% with ETFE (p=0. 217. Ovulatory worsening was observed in 36 (17% patients with MTLE and 13 (26.5% with ETFE (p=0,126. Catamenial worsening was observed in 58 (27.4% of the patients with MTLE and in 17 (34.7% of the patients with ETFE (p=0.315. CONCLUSION: There was no difference between the group of patients with MTLE and ETFE regarding the frequency of irregular cycles and seizure worsening during the premenstrual, menstrual, catamenial or ovulatory periods.INTRODUÇÃO: Admite-se que a flutuação hormonal seja a responsável para a piora de crises epilépticas no período catamenial. OBJETIVO: Identificar irregularidades nos ciclos menstruais de mulheres com epilepsia de lobo temporal mesial (ELTM e epilepsia focal extratemporal (EFET; e relacionar a frequencia de crises durante o ciclo menstrual. MÉTODO: Avaliamos mulheres na menacme, que apresentem quadro clínico laboratorial compatível com ELTM e EFET. Foram

  9. Estrategias para mejorar el cumplimiento de la farmacoterapia antiepiléptica en los pacientes con epilepsia

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    Sinaa Al-Aqeel

    2013-11-01

    Conclusiones de los autores: Las intervenciones con recordatorios intensivos y con “intención de implementación” parecen alentadoras para mejorar el cumplimiento con las medicaciones antiepilépticas; sin embargo, antes de establecer una conclusión firme se necesitan pruebas más confiables de su eficacia a partir de ensayos controlados aleatorios cuidadosamente diseñados.

  10. Questionnaire study of primary care physicians’ referral patterns and perceptions of patients with epilepsy in a Brazilian city, 2005 Encuesta sobre los patrones de remisión y las percepciones de los médicos de atención primaria con respecto a los pacientes con epilepsia en una ciudad brasileña, 2005

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    Vanessa Teixeira Müller

    2007-07-01

    Full Text Available A una muestra de médicos de familia del Programa de Médicos de Familia de Niterói, Río de Janeiro, Brasil, se aplicó en abril de 2005 un cuestionario autoadministrado para determinar la percepción de los médicos de atención primaria sobre la calidad del servicio para epilepsia y los patrones de remisión y su opinión sobre la atención que se brinda. Los encuestados consideraron que los neurólogos deben ser los responsables del diagnóstico y de la prescripción inicial de medicamentos antiepilépticos, mientras que los médicos de familia se deben responsabilizar de la atención subsiguiente. Los encuestados informaron estar insatisfechos con sus conocimientos sobre la epilepsia y los medicamentos antiepilépticos. Se consideró que los profesionales mejor calificados para la atención de la epilepsia son los neurólogos (58,9%, seguidos de los médicos de familia (35,7%. Casi todos los encuestados consideraron que los lineamientos y seminarios mejoraron su capacidad para atender a sus pacientes. Los encuestados no se sentían seguros de la atención que brindaban a los pacientes con epilepsia y por lo general los remitían al neurólogo. Sin embargo, el Programa de Médicos de Familia tiene un potencial inexplotado para tratar a los pacientes con epilepsia, debido al interés de estos profesionales en mejorar su calificación.

  11. Sueño y epilepsia

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    M. Julia Santín, Dra.

    2013-05-01

    Esta interrelación es recíproca, múltiple y compleja. Incluye dificultades diagnósticas semiológicas entre epilepsia y parasomnias, impacto de algunos trastornos del sueño en el control de la epilepsia, relación del ciclo sueño-vigilia con la aparición de crisis, efecto del sueño en la morfología de las descargas epileptiformes, fragmentación del sueño por crisis nocturnas frecuentes, efectos de la privación de sueño sobre la epilepsia y su rol como activador de descargas epileptiforme y crisis, efectos de los fármacos antiepilépticos en el nivel de vigilancia diurna y en la calidad del sueño nocturno, etc.

  12. Factores de riesgo en epilepsia

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    José William Cornejo Ochoa

    1990-03-01

    Full Text Available e analizaron 1.961 encuestas correspondientes a 1.131 casos de epilepsia y 830 controles, con el objeto de medir la asociación entre
    esta enfermedad y las siguientes variables: factor heredo-familiar, riesgo obstétrico, infecciones del sistema nervioso central, infecciones virales de la infancia y trauma del cráneo. Se validó el formulario analizando la presencia de infecciones urinarias, la colaboración a la entrevista y la duración de ésta; no se hallaron, en tales aspectos,
    diferencias significativas entre los casos y los controles.

  13. Periventricular nodular and subcortical neuronal heterotopia in adult epileptic patients Heterotopía neuronal nodular y subcortical en pacientes adultos con epilepsia

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    Damián E. Consalvo

    2006-04-01

    Full Text Available Developmental malformations are brain abnormalities that occur during embryogenesis. Neuronal migration disorders, including heterotopic lesions, constitute one type of such abnormalities. The aim of the study was to compare the epileptic clinical patterns of patients with periventricular nodular heterotopia (PNH (G1 with those affected by subcortical heterotopia (SCH (G2 looking for differences between both groups which, eventually, might suggest the type of the underlying malformation. The variables studied in both groups were: type of the heterotopia depicted on MRI studies, sex, age, age at seizure onset, annual seizure frequency, localization of the ictal symptomatogenic zone, characteristics of the EEG, other associated anomalies on the magnetic resonance images (MRI besides the heterotopia, and response to treatment. The only difference found between both groups was the type of heterotopia as shown by MRI studies. The other assessed variables did not significantly (p>0.05 differ between groups. No differences in the clinical features characterizing epilepsy could be found in patients with PNH or SCH, being the images the only tool able to differentiate them.Las malformaciones de la corteza cerebral son un grupo de entidades que se producen durante las etapas del desarrollo embrionario y cuya manifestación clínica puede ser la epilepsia. Estas malformaciones pueden ser diagnosticadas in vivo a través de las imágenes por resonancia magnética (IRM. Un subtipo particular de éstas lo constituyen los trastornos en la migración neuronal, dentro de los cuales se ubican las heterotopías (HT. El objetivo del estudio fue comparar enfermos portadores de HT periventriculares (G1 con aquellos portadores de HT subcorticales (G2. Se analizaron las variables sexo, edad y edad de inicio de la epilepsia (EI en años, antecedentes familiares (AF o prenatales (AP, frecuencia anual de crisis (FAC y características semiológicas de las crisis

  14. Sequential motor task (Luria's Fist-Edge-Palm Test in children with benign focal epilepsy of childhood with centrotemporal spikes Tarefa motora sequencial (Teste de Lúria punho-lado-palma em crianças com epilepsia focal benigna da infância com descarga centrotemporal

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    Carmen Silvia Molleis Galego Miziara

    2013-06-01

    Full Text Available This study evaluated the sequential motor manual actions in children with benign focal epilepsy of childhood with centrotemporal spikes (BECTS and compares the results with matched control group, through the application of Luria's fist-edge-palm test. The children with BECTS underwent interictal single photon emission computed tomography (SPECT and School Performance Test (SPT. Significant difference occurred between the study and control groups for manual motor action through three equal and three different movements. Children with lower school performance had higher error rate in the imitation of hand gestures. Another factor significantly associated with the failure was the abnormality in SPECT. Children with BECTS showed abnormalities in the test that evaluated manual motor programming/planning. This study may suggest that the functional changes related to epileptiform activity in rolandic region interfere with the executive function in children with BECTS.Esse estudo avaliou ações motoras manuais sequenciais em crianças com epilepsia focal benigna da infância com descarga centrotemporal (EBICT e comparou os resultados com o grupo controle pareado, através do teste de Lúria (punho-lado-palma. As crianças com EBICT realizaram single photon emission computed tomography (SPECT interictal e Teste de Desempenho Escolar (TDE. Foram encontradas diferenças significativas entre os dois grupos nas atividades motoras de três movimentos iguais e três movimentos diferentes. As crianças com piores resultados no TDE e com SPECT alterado apresentaram mais erros no teste de imitação manual. Crianças com epilepsia fracassaram nos testes de avaliação motora que envolvem programação/planejamento. Esse estudo sugere que mudanças funcionais relacionadas à atividade epileptiforme na região rolândica interfere com as funções executivas de crianças com EBICT.

  15. A radioterapia profunda em doses elevadas na epilepsia focal: contrôle clínico e eletrencefalográfico

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    Paulo Pinto Pupo

    1954-06-01

    Full Text Available Radiotherapy in high doses has been used in cases of symptomatic epilepsy with the purpose of to act against the focal epileptic activity, as coadjuvancy to the common medical treatment. Patients with clinical manifestations of epilepsy in whom convulsive foci were demonstrated in the EEG, have been selected; these foci have been recognized as well localized and well circunscribed, and in all them the etiology has been the same (atrophic lesions, according to the clinical and radiological (craniogram, pneumoencephalogram and arteriogram examinations. The purpose of a so homogenous group was to study the results to be obtained in similar conditions. Twenty patients have been selected from a group of forty-eight, because it was possible to obtain a good follow-up for at least three months in each case. In all cases, a medical treatment (barbiturate plus hidantoi-nate has been used in uniform manner, with the purpose of avoiding influence on the judgement of the value of radiotherapy, for it was impossible to interrupt the drug therapy. Radiotherapy has been used in high doses over the epileptic lesion, which had been localized by the EEG. Two different techniques were used; in both 200 kv, 0.5 mm. filter of Cu were employed. Fourteen patients were irradiated in four different areas, of 4 cm. in diameter each one; they received 150 r daily, 2 areas by day, performing an average total of 3,000 r. In the other 6 cases the technique of kinetic convergent radiotherapy was employed, using the Siemens apparatus; each patient received, through a cutaneous area, an average doses of 3,000 r into the focus and 2,000 r in the skin; they received from 100 r to 150 r in the focus daily. Studying the twenty cases individually, there was marked EEG improvement in 4, relative improvement in 8 and no change in 8; there was marked decrease in the number of seizures in 8, relative decrease in 10 and no change in 2; the mental status was markedly improved in 7

  16. Suplementación con vitamina D en epilepsia: estudio en pacientes con antiepilépticos clásicos y de nueva generación

    OpenAIRE

    Villegas Martinez, Irene

    2016-01-01

    INTRODUCCIÓN Y OBJETIVOS: el metabolismo óseo es un sistema complejo en el que intervienen numerosos actores, como la vitamina D. Los farmacos antiepilépticos (FAEs) clásicos como la carbamacepina (CBZ), la fenitoína (PHT) o el ácido valproico (VPA), se han relacionado con la aparición de una osteoporosis prematura en los pacientes epilépticos y se recomienda la suplementación con vitamina D, pero la dosis e incluso el tipo de suplementación no está clara. También se desconoce el impacto de l...

  17. Valor localizador y lateralizador de la manifestación motora facial unilateral en epilepsias focales, utilizando VEEG y/o estimulación cortical directa cerebral

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    Natalia Paoli

    2014-07-01

    Full Text Available Las manifestaciones motoras faciales unilaterales (MMFU se describen clásicamente en crisis que inician en la región central inferior contralateral. Para evaluar el valor localizador y lateralizador de MMFU en crisis espontáneas registradas en videoelectroencefalografía (VEEG y de MMFU obtenidas por estimulación cortical directa cerebral, analizamos 83 crisis con MMFU durante VEEG y 8 pacientes que presentaron MMFU durante estimulación cortical directa cerebral. Correlacionamos localización y lateralidad de la hipótesis de zona epileptógena con el tiempo de aparición  de MMFU, y la zona de estimulación cortical directa cerebral que desencadenó MMFU con su lateralidad. En 61 crisis con MMFU (73.4% la hipótesis de zona epileptógena no correspondió a la región central contralateral, por corresponder a la región central ipsilateral o a otras regiones tanto homolaterales como contralaterales. La MMFU se registró en forma precoz en 51.1% de las crisis con hipótesis de zona epileptógena en la región frontal, en  56% de las crisis con hipótesis de zona epileptógena en la región central y en 80% de las crisis con hipótesis de zona epileptógena en el lóbulo temporal. No registramos MMFU precoz  en las crisis con hipótesis de zona epileptógena en la región posterior. En 2 (25% de 8 pacientes con MMFU provocada por estimulación cortical directa cerebral, la zona de la estimulación no fue la región central inferior contralateral. Concluimos que las MMFU pueden deberse a descargas alejadas de la región central inferior, tanto ipsilaterales como contralaterales.

  18. Statistical model of intensity noise in con focal fluorescence microscopy images

    International Nuclear Information System (INIS)

    Montereali, R.M.; Almaviva, S.; Franzini, I.; Somma, F.

    2008-01-01

    The visible photoluminescence of aggregate F2 and F3+ color centers in Lithium Fluoride (LiF) thin layers, grown by thermal evaporation on various substrates (either crystalline or not) with different thicknesses, can be efficiently observed by using an optical con focal fluorescence microscope and a laser pump with emission wavelength tuned at about 450 nm. Starting from con focal fluorescence images of uniformly colored LiF samples, an automatic routine for the estimation of photoluminescence intensity noise has been developed at the Solid State Laser Laboratory and Spectroscopy of the ENEA Research Center in Frascati. We reported experimental results about application of that routine to the photoluminescence of LiF thin films, uniformly irradiated with an X-ray tube with energy spectrum centered on the Cu K? emission line (8,03 keV), at the CNR-IFN in Rome, that allow to identify a suitable statistical model for his description [it

  19. Alteraciones del desarrollo físico y sexual en varones prepúberes y púberes con epilepsia y su asociación con la administración de fármacos antiepilépticos y las características clínicas y paraclínicas de la epilepsia en el HUSVP de Medellín, en 2005-2006

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    María Cristina Jaramillo

    2008-02-01

    Full Text Available

     

    ANTECEDENTES: se han descrito diversas alteraciones endocrinas y de la salud sexual en adultos y mujeres púberes con epilepsia. En varones púberes hay pocos estudios al respecto y ninguno en Colombia.

    OBJETIVOS: establecer la frecuencia de alteraciones del desarrollo físico y sexual de varones prepúberes y púberes con epilepsia y explorar su asociación con la administración de fármacos antiepilépticos y las características clínicas, electroencefalográficas e imaginológicas.

    MÉTODOS: se evaluaron 29 varones con epilepsia, entre 8 y 18 años, que no recibían esteroides ni tenían retardo mental moderado o grave, parálisis cerebral o trastornos endocrinos. Los datos se obtuvieron de una entrevista estructurada a los padres, de los registros médicos y de una evaluación de la maduración física y sexual (antropometría, Tanner, longitud del pene y volumen testicular.

    RESULTADOS: dos pacientes (6,9% presentaron alteración del desarrollo sexual; 9 (31% tenían alteración del desarrollo físico: sobrepeso 20,7%, obesidad 6

  20. Epilepsia y anticonceptivos

    OpenAIRE

    Burgos S., Nelson; Parra A., Manuel

    2004-01-01

    La epilepsia es una enfermedad neurológica que puede afectar a la mujer en edad fértil. Es conocido que las terapias anticonvulsivantes pueden disminuir la efectividad de los anticonceptivos hormonales. Los principales mecanismos son una mayor estimulación del sistema enzimático hepático de la citocromo P450 y el aumento de los niveles de la globulina transportadora de hormonas sexuales. Como consecuencia se produce una disminución de los niveles disponibles de los anticonceptivos hormonales,...

  1. Papel de la monoterapia con nuevos fármacos antiepilépticos en el tratamiento de la epilepsia infantil Role of monotherapy with new antiepileptic drugs in the treatment of childhood epilepsy

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    Ignacio Valencia

    2009-01-01

    Full Text Available En este trabajo se revisa la información actual sobre el uso de los nuevos fármacos antiepilépticos (FAEs en monoterapia en niños, resaltando nuestra experiencia personal. Específicamente, se incluyen los siguientes FAEs: lamotrigina (Lamictal®, topiramato (Topamax®, zonisamida (Zonegran®, levetiracetam (Keppra®, y oxcarbacepina (Trileptal®. Todos estos FAEs tienen un amplio espectro de acción en el tratamiento de crisis epilépticas parciales y generalizadas, excepto la oxcarbacepina, que es eficaz exclusivamente en crisis parciales. No está claro si la monoterapia con estos FAEs, en comparación con los FAEs clásicos (fenobarbital, fenitoína, carbamacepina, valproato sódico, proporciona una mayor eficacia y/o causa menos efectos secundarios y, si por lo tanto, mejora significativamente la calidad de vida de los niños con epilepsia. Se necesitan más estudios para poder contestar estas preguntas.In this paper we review the current information regarding the use of new antiepileptic drugs (AEDs used as monotherapy in children. We specifically include the following AEDs: lamotrigine (Lamictal®, topiramate (Topamax®, zonisamide (Zonegran®, levetiracetam (Keppra®, and oxcarbazepine (Trileptal®. All of these AEDs have a broad spectrum of action in the treatment of partial and generalized seizures, except Oxcarbazepine, which is effective only in partial seizures. It is unclear whether or not monotherapy with the new AEDs offers higher efficacy and/or lower side effects compared to classic AEDs (phenobarbital, phenytoin, carbamazepine, or valproate thereby significantly improving the quality of life in children with epilepsy. More studies are needed to answer these questions.

  2. Bostezo y epilepsia del lóbulo temporal Yawning and temporal lobe epilepsy

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    S. Muchnik

    2003-04-01

    Full Text Available La epilepsia del lóbulo temporal, es aquella epilepsia parcial donde las estructuras temporales límbicas son las responsables de los principales síntomas ictales. Se caracteriza por la recurrencia de crisis parciales simples y complejas con confusión post-ictal y amnesia del evento. El efecto facilitador del sueño No REM en la propagación de las crisis, como las anormalidades del sueño provocadas por la epilepsia del lóbulo temporal, son evidenciadas claramente en nuestros pacientes. El bostezo es un reflejo fisiológico, principalmente inducido por el despertar y el adormecimiento, puede estar asociado a diferentes enfermedades neurológicas. Su relación con la epilepsia de origen límbico, ha sido escasamente mencionada. Describimos en un paciente, un episodio de bostezos y crisis parcial compleja mientras dormitaba. El EEG mostró actividad irritativa focal, independiente y bilateral en regiones temporales medias. Tratado con carbamazepina 400mg/d, no repitió el episodio. Otro paciente presentó crisis parciales complejas secundariamente generalizadas con episodios de bostezos en el período post-ictal, luego de las siestas. El EEG fue normal y la polisomnografía nocturna mostró actividad irritativa sincrónica y bilateral en regiones temporales medias con generalización secundaria. Tratado con divalproato de sodio 750 mg/d, no se registraron nuevos episodios. La epilepsia del lóbulo temporal, el ciclo sueño-vigilia y el bostezo, parecen compartir no solamente las mismas estructuras anatómicas, sino también los mismos mecanismos neuroquímicos. El hecho de que los opiáceos endógenos sean considerados como parte de un sistema protector que inhibe y previene las crisis, permite postular que el bostezo sería la expresión de los mecanismos inducidos por los opiáceos endógenos que inhiben y previenen las crisis de la epilepsia del lóbulo temporal. Otro punto de vista sería presentar al bostezo simplemente como una forma

  3. A epilepsia nos tumores cerebrais

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    Luís Marques-Assis

    1969-03-01

    Full Text Available De 411 casos de tumores cerebrais foram estudados 86 (19,4% que apresentaram manifestações epilépticas. A epilepsia foi estudada quanto à duração, ao tipo de manifestação e à severidade, em relação à natureza e à localização dos tumores cerebrais. A análise dos resultados permitiu aos autores chegarem às seguintes conclusões: 1 a epilepsia incidiu em 19,4% dos casos; 2 o oligodendroglioma, as metástases carcinomatosas e o glioblastoma multiforme foram, pela ordem, os tumores mais epileptogênicos; 3 as áreas frontal, parietal e temporal foram, nessa ordem, as localizações mais epileptogênicas; 4 os carcinomas metastáticos predominaram nos casos com epilepsia com menos de um ano de evolução, enquanto que os astrocitomas predominaram nos casos com mais de três anos; quanto à topografia, predominou a região frontal no primeiro grupo e a temporal, no segundo; 5 nas formas mais severas de epilepsia predominaram os oligodendrogliomas e os meningeomas, quanto à natureza, e a região frontotemporal e a foice, quanto à localização; 6 os craniofaringeomas e os meduloblastomas foram os tumores que mais freqüentemente determinaram o aparecimento de convulsões puras; nesses casos, a sela túrsica e a fossa posterior foram as sedes mais freqüentes; 7 os carcinomas metastáticos e os meningeomas, quanto à natureza, e as regiões frontoparietal e parietal, quanto à localização, foram os mais freqüentemente encontrados nos casos com crises de tipo bravais-jacksoniano.

  4. Rasmussen's encephalitis presenting as focal cortical dysplasia

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    D.J. O'Rourke

    2014-01-01

    Full Text Available Rasmussen's encephalitis is a rare syndrome characterized by intractable seizures, often associated with epilepsia partialis continua and symptoms of progressive hemispheric dysfunction. Seizures are usually the hallmark of presentation, but antiepileptic drug treatment fails in most patients and is ineffective against epilepsia partialis continua, which often requires surgical intervention. Co-occurrence of focal cortical dysplasia has only rarely been described and may have implications regarding pathophysiology and management. We describe a rare case of dual pathology of Rasmussen's encephalitis presenting as a focal cortical dysplasia (FCD and discuss the literature on this topic.

  5. Rasmussen's encephalitis presenting as focal cortical dysplasia

    Science.gov (United States)

    O'Rourke, D.J.; Bergin, A.; Rotenberg, A.; Peters, J.; Gorman, M.; Poduri, A.; Cryan, J.; Lidov, H.; Madsen, J.; Harini, C.

    2014-01-01

    Rasmussen's encephalitis is a rare syndrome characterized by intractable seizures, often associated with epilepsia partialis continua and symptoms of progressive hemispheric dysfunction. Seizures are usually the hallmark of presentation, but antiepileptic drug treatment fails in most patients and is ineffective against epilepsia partialis continua, which often requires surgical intervention. Co-occurrence of focal cortical dysplasia has only rarely been described and may have implications regarding pathophysiology and management. We describe a rare case of dual pathology of Rasmussen's encephalitis presenting as a focal cortical dysplasia (FCD) and discuss the literature on this topic. PMID:25667877

  6. DISPLASIAS CORTICALES COMO CAUSA DE EPILEPSIA Y SUS REPRESENTACIONES EN LAS IMÁGENES

    OpenAIRE

    Gálvez M, Marcelo; Rojas C, Gonzalo; Cordovez M, Jorge; Ladrón de Guevara, David; Campos P, Manuel; López S, Isabel

    2009-01-01

    La epilepsia es una alteración neurológica crónica caracterizada por crisis convulsivas recurrentes y espontáneas, que clínicamente se clasifican como generalizadas o parciales, dentro de las cuales aproximadamente el 30% de los pacientes con epilepsia parcial son refractarios al tratamiento médico. Dentro del grupo refractario debemos descartar la presencia de una displasia cortical como causa subyacente de las crisis. Las displasias corticales son un tipo de malformaciones del desarrollo co...

  7. Epilepsia en menores de 3 años

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    Nadia Gutiérrez

    1996-08-01

    Full Text Available Se estudiaron 96 pacientes menores de 3 años, ingresados en el Servicio de Neurología Pediátrica de nuestro Centro, con diagnóstico de epilepsia, con el objetivo de evaluar la aplicación de la clasificación de los ataques, la de Epilepsia y Síndromes Epilépticos aceptados actualmente por la Liga Internacional Contra la Epilepsia (ILAE. En ellos se observó con mayor frecuencia la presentación de ataques parciales (58,3 %, seguido de los generalizados (36,5 % e indeterminados (5 %; no se presentaron diferencias significativas respecto a la distribución de éstos entre menores de 1 año y los comprendidos en edades entre 1 y 3 años. En 28 pacientes se encontraron dificultades para clasificarlos acorde con la de Epilepsia y Síndromes Epilépticos, y se analizaron su distribución y características. Se comentan brevemente los resultados del electroencefalograma (EEG en relación con la actividad paroxística y se presentan los síndromes más frecuentemente observados.96 patients under 3 years old admitted at the Pediatric Neurologic Department of our Center with an epilepsy diagnosis were studied to evaluate the application of the seizure classification into Epilepsy and Epileptic Syndromes, accepted at present by the International League Against Epilepsy (ILAE. Partial seizures (58,3 % were more frequent among them, followed by generalized seizures (36,5 % and undetermined seizures (5 %. No significant differences were found in connection with their distribution among children under one year old and those between 1 and 3 years old. Difficulties were observed to classify 28 patients according to Epilepsy and Epileptic Syndromes, where as their distribution and characteristics were analyzed. EEG results in relation to the paroxyntic activity are briefly commented and the most observed syndromes are presented.

  8. The con focal laser scanning microscope: a powerful tool for the investigation of micro devices and nano structures

    International Nuclear Information System (INIS)

    Montereali, R.M.; Baldacchini, G.; Bonfigli, F.; Vincenti, M.A.; Almaviva, S.

    2008-01-01

    In the last years the Con focal Laser Scanning Microscope (CLSM), a versatile and powerful optical instrument, gained a strong increase of interest in the scientific community, not only for biological applications, but also for the characterization of materials, microstructures and devices. The conditions that favoured its wide diffusion are surely the large availability of laser sources and powerful computer-imaging and data-processing systems at relatively low cost; however, the main reason that contributed to its popularity is the ability to obtain tri dimensional reconstruction of a great variety of biological and non-biological samples with sub micrometric resolution. In this report we show the main properties and characteristics of the Con focal Microscope Nikon Eclipse 80-i C1, which has operated sinc more than two years in the Solid State Laser and Spectroscopy Laboratory of the ENEA Research Center in Frascati. Some of the results obtained in the characterization of luminescent micro and nano structures based on lithium fluoride color centers will be presented [it

  9. Manejo terapéutico actual de la epilepsia refractaria a los medicamentos antiepilépticos clásicos

    OpenAIRE

    Tania García Arias; Indira López Gutiérrez; Lourdes María García Illán

    2015-01-01

    La epilepsia es una afección frecuente del sistema nervioso central y una de las primeras causas de morbilidad neuropediátrica. Un problema terapéutico actual es el número de pacientes con epilepsia refractaria a los medicamentos antiepilépticos clásicos. Se realizó una revisión bibliográfica actualizada, empleando los servicios disponibles en la red Infomed, sobre los nuevos enfoques terapéuticos de la epilepsia refractaria a los antiepilépticos clásicos. En la literatura se evidencia cómo s...

  10. Sueño y epilepsia

    OpenAIRE

    Julia Santín, M.

    2013-01-01

    La relación entre epilepsia y sueño ha sido descrita desde hace más de dos mil años. Es así como Aristóteles en “Sobre el Sueño y la Vigilia” describe “tanto el sueño como la epilepsia atacan, y en ese sentido el sueño es una crisis. Consecuentemente en muchos casos la epilepsia comienza en el sueño y hay hombres que convulsionan durante el sueño pero no cuando están despiertos”. En tanto Hipócrates menciona en uno de sus aforismos “miedos, furia, delirio, saltos de la cama y convulsiones dur...

  11. Epilepsia partialis continua responsive to neocortical electrical stimulation.

    Science.gov (United States)

    Valentin, Antonio; Ughratdar, Ismail; Cheserem, Beverly; Morris, Robert; Selway, Richard; Alarcon, Gonzalo

    2015-08-01

    Epilepsia partialis continua (EPC), defined as a syndrome of continuous focal jerking, is a rare form of focal status epilepticus that usually affects a distal limb, and when prolonged, can produce long-lasting deficits in limb function. Substantial electrophysiologic evidence links the origin of EPC to the motor cortex; thus surgical resection carries the risk of significant handicap. We present two patients with focal, drug-resistant EPC, who were admitted for intracranial video-electroencephalography monitoring to elucidate the location of the epileptogenic focus and identification of eloquent motor cortex with functional mapping. In both cases, the focus resided at or near eloquent motor cortex and therefore precluded resective surgery. Chronic cortical stimulation delivered through subdural strips at the seizure focus (continuous stimulation at 60-130 Hz, 2-3 mA) resulted in >90% reduction in seizures and abolition of the EPC after a follow-up of 22 months in both patients. Following permanent implantation of cortical stimulators, no adverse effects were noted. EPC restarted when intensity was reduced or batteries depleted. Battery replacement restored previous improvement. This two-case report opens up avenues for the treatment of this debilitating condition. Wiley Periodicals, Inc. © 2015 International League Against Epilepsy.

  12. Epilepsia e Comorbilidades Psiquiátricas

    Directory of Open Access Journals (Sweden)

    Alexandra Filipa Novais Araújo

    2016-07-01

    Full Text Available Introdução: A epilepsia é uma doença neurológica crónica prevalente. Devido a fatores biológicos, psicológicos e sociais, os afetados pela doença apresentam maior susceptibilidade de desenvolvimento de morbilidades psiquiátricas. Objetivos: Revisão crítica da associação entre epilepsia e patologia psiquiátrica, permitindo aos clínicos uma abordagem mais consciente e informada. Métodos: Os artigos incluídos foram seleccionados através da base de dados Pubmed com a query “((“Epilepsy”[Mesh] AND “Mental Disorders”[Mesh] AND “Comorbidity”[Mesh]”. Adicionalmente foram consultados relatórios oficiais da Internacional League Against Epilepsy e World Health Organization. Resultados e Conclusões: Cerca de 15% a 70% dos doentes com epilepsia apresentam patologia psiquiátrica, que pode ser classificada em peri-ictal ou inter-ictal. A depressão é a patologia mais frequente, podendo ter uma prevalência de 70%, seguida das perturbações de ansiedade. A relação entre epilepsia e psicose poderá dever-se ao papel etiológico comum da patologia cerebral subjacente. As crises não epiléticas psicogénicas configuram um desafio diagnóstico e terapêutico, tendo uma apresentação clínica sugestiva de crises epiléticas mas sem as alterações eletrofisiológicas correspondentes, podendo surgir em doentes com e sem epilepsia. Apesar da sua heterogeneidade, os diferentes estudos globalmente evidenciam uma prevalência aumentada de patologia psiquiátrica em doentes com epilepsia. A natureza da relação entre estas patologias ainda não está inequivocamente esclarecida, revelando a insuficiência de conhecimento sobre esta temática. O presente trabalho reforça a necessidade da intervenção multidisciplinar por parte da neurologia, psiquiatria e psicologia, em indivíduos com epilepsia e patologia psiquiátrica concomitante.

  13. Tegretol no tratamento da epilepsia Tegretol in the treatment of epilepsy

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    Jorge Armbrust-Figueiredo

    1968-09-01

    Full Text Available O Tegretol (5-carbamil-5H-dibenzo-b,L-azepina foi usado no tratamento de 68 pacientes com epilepsia; 54 apresentavam epilepsia temporal (42 com crises psicomotoras e 12 com crises complexas, 11 epilepsia focal de projeção não temporal e 3 epilepsia centrencefálica com crises P.M. Resultados satisfatórios foram observados em 82% dos 65 pacientes com epilepsia focal; os 3 pacientes com crises P.M. não foram influenciados pelo tratamento. A ação sobre as manifestações psíquicas que acompanhavam o quadro crítico ou intercrítico das crises ficou bem evidenciada. Os pacientes melhoraram de seus sintomas na grande maioria dos casos, conseguindo adaptar-se melhor no ambiente familiar, profissional e escolar. O efeito sobre as alterações eletrencefalográficas é moderado, e a evolução clínica não acompanha as modificações dos traçados. As doses usadas, em geral de 400 a 600 mg diários, são suficientes para o controle das crises na maioria dos casos e estão muito abaixo dos limites considerados como de segurança. As reações secundárias foram observadas em pequeno número de casos e foram sempre transitórias. O Tegretol representa, em nossa opinião, recurso de valor no trataemnto das epilepsias focais, particularmente nas crises psicomotoras.Tegretol (5-carbanyl-5H-dibenzo-b,L-azepina was used experimentally in the theatment of 68 epileptic patients; 54 had temporal lobe epilepsy (42 had psychomotor and 12 had complex seizures, 11 had focal non-temporal lobe epilepsy and 3 had P.M. epilepsy. Satisfactory results were obtained in 82 per cent of the 65 patients with focal epilepsy, but failure of the treatment was observed in all cases of P.M. epilepsy. The drug has a very good influence on the critical and intercritical mental phenomena which are frequently present in these patients. The personality of the patient improves and he becomes better adjusted to his family, his work or school. The action of the electroencephalogram

  14. Menkes Disease Presenting with Epilepsia Partialis Continua

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    Tamer Rizk

    2014-01-01

    Full Text Available Aim. We aim to describe a female patient with Menkes disease who presented with epilepsia partialis continua. Case Presentation. Seventeen-months-old Saudi infant was presented with repetitive seizures and was diagnosed to have epilepsia partialis continua. Discussion. Menkes disease (OMIM: 309400 is considered a rare, X-linked recessive neurodegenerative disorder resulting from a mutation in the gene coding for the copper transporting ATPase (ATP7A. Affected individuals usually present with kinky hair, skeletal changes, prolonged jaundice, hypothermia, developmental regression, decreased tone, spasticity, weakness, and therapy resistant seizures. Conclusion. Raising awareness of abnormal presentation of this rare disease may help in the control of seizures through subcutaneous copper supplementation.

  15. Abordaje de la epilepsia en la infancia.: Parte I

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    Roberto Álvarez Fumero

    1997-10-01

    Full Text Available El presente artículo cumple el objetivo de exponer algunas consideraciones que deben tener en cuenta los médicos de la familia, pediatras y neurólogos, en el manejo integral del niño con epilepsia. Insistimos en la importante información que aporta la anamnesis y la realización de un exhaustivo examen físico neurológico. Resaltamos el valor del examen del fondo de ojo y de la piel y sus anexos. Mostramos las ventajas, desventajas e indicaciones de los estudios imagenológicos, exhortando a su utilización más racional. Alertamos sobre el uso rutinario de los estudios de biometría hemática, pruebas metabólicas en orina y examen del líquido cefalorraquídeo, en el diagnóstico de la epilepsia. Mencionamos los recientes avances de la cibernética aplicada a la neurología. Consideramos útil la valoración multidisciplinaria de estos niños.Some of the considerations that should be taken into account by family physicians, pediatricians and neurologists in the comprehensive management of children with epilepsy are exposed. Emphasis is made on the important information obtained from the anamnesis and from an exhaustive physical and neurological examination. The value of the examination of the fundus oculi, the skin and its adnexa is stressed. The advantages, disadvantages and indications of the images studies are shown, encouraging their more rational use. A warning is given on the rutinary use of hematic biometry studies, metabolic tests in urine and cerebrospinal examination in the diagnosis of epilepsy. The latest advances of cybernetics applied to neurology are also mentioned. The multidisciplinary evaluation of these children is considered as useful.

  16. Manejo terapéutico actual de la epilepsia refractaria a los medicamentos antiepilépticos clásicos

    Directory of Open Access Journals (Sweden)

    Tania García Arias

    2015-02-01

    Full Text Available La epilepsia es una afección frecuente del sistema nervioso central y una de las primeras causas de morbilidad neuropediátrica. Un problema terapéutico actual es el número de pacientes con epilepsia refractaria a los medicamentos antiepilépticos clásicos. Se realizó una revisión bibliográfica actualizada, empleando los servicios disponibles en la red Infomed, sobre los nuevos enfoques terapéuticos de la epilepsia refractaria a los antiepilépticos clásicos. En la literatura se evidencia cómo se ha revolucionado el tratamiento médico y el pronóstico, al complementar el manejo tradicional de esta entidad con la introducción de los antiepilépticos de segunda generación o nuevos antiepilépticos

  17. Grupos focales de discusión: estrategia para la investigación sobre salud sexual con adolescentes con experiencia de vida en calle en Medellín, Colombia

    Directory of Open Access Journals (Sweden)

    Diana Castro A

    2016-09-01

    Full Text Available La intención de este artículo es evidenciar la importancia de los grupos focales de discusión como estrategia metodológica para la recolección de información en el trabajo con adolescentes institucionalizados con experiencia de vida en calle y, al mismo tiempo, mostrar su valor en el abordaje de la salud sexual con esta población, en tanto que permite una interacción flexible y reflexiva entre investigadores y participantes, así como de los participantes entre sí. El valor de esta estrategia metodológica es sustentado en este artículo mediante testimonios y resultados obtenidos durante su implementación en el estudio llevado a cabo con adolescentes institucionalizados entre 2013 y 2014 en Medellín. Se espera con este reducir las creencias de profesionales con respecto a las limitaciones de la estrategia para abordar temáticas relacionadas con la salud sexual de este grupo poblacional. Los resultados se articulan en cuatro categorías: conocimientos y percepciones sobre vih e its, salud sexual y reproductiva (ssr, el lenguaje en la ssr, y acceso y uso de las tecnologías de la información y la comunicación (tic. De esta manera, se deja de manifiesto el aporte y potencial de la estrategia para el abordaje del tema y para el acercamiento e interacción con adolescentes con experiencia de vida en calle.

  18. Epilepsia en el niño: Edad de inicio, tiempo de evolución y situación escolar. Su relación con el rendimiento intelectual

    Directory of Open Access Journals (Sweden)

    Clemente Trujillo Matienzo

    1997-04-01

    Full Text Available Se estudiaron 310 escolares epilépticos atendidos en el Instituto de Neurología y Neurocirugía con edades entre 5 y 14 años. Se les estudió rendimiento intelectual (test de inteligencia de Terman Merrill clasificado según la escala y se relacionó mediante el test de diferencias de medias con la edad de inicio de la enfermedad, el tiempo de evolución y la situación académica de cada niño. Se encontró que el grupo con retraso escolar difiere del que no lo tiene en cuanto a promedio alto (p 310 epileptic school children between 5 and 14 years old who were attended at the Institute of Neurology and Neurosurgery entered this study. Their academic results were studied (Terman and Merrill's intelligence test and classified according to the scale and they were related to the age of onset of the disease, the time of evolution, and the academic situation of each child by using the test of differences of averages. It was found that the group with school retardation differs from the other one in the following aspects: high average (p < 0,01, low average, mild and moderate deficient (p < 0,0001, and severe deficient (p < 0,001. It is concluded that among epileptic school children there are differences as regards the academic performance between those who do not have school retardation and those who have it, and between those with 5 or less years of evolution of the disease and those ones with more.

  19. Construcción del concepto de especie focal a través de una indagación con escarabajos coprófagos: propuesta metodológica

    OpenAIRE

    Echeverri Tique, José Javier

    2011-01-01

    La propuesta metodológica para la construcción del concepto de especie focal a través de la indagación con escarabajos coprófagos, se fundamenta en el Aprendizaje Basado en Problemas y la indagación científica articulada con el monitoreo biológico con escarabajos coprófagos y su función como bioindicadores en la construcción de conocimiento. / Abstract. The proposed methodology for the construction of the focal species concept through inquiry and dung beetles, is based on problem-based learni...

  20. Epilepsia e dieta cetogénica

    OpenAIRE

    Oliveira, Tiago Carvalheira Côrte-Real

    2003-01-01

    Resumo da tese: Aproximadamente 1 em cada 5 pessoas com epilepsia tem crises persistentes que não respondem ao tratamento farmacológico. A dieta cetogénica, introduzida por Wilder em 1921, continua a ser uma das terapias com maior eficácia no tratamento das crises epilépticas fármaco-ressistentes. É uma dieta rica em gordura e pobre em hidratos de carbono e proteína, desenhada com o objectivo de simular um jejum prolongado. Apesar de não ser conhecido o seu mecanismo de acção, acredita-se que...

  1. Parasitosis y Micosis del Sistema Central como Causa de Epilepsia en Adultos

    Directory of Open Access Journals (Sweden)

    Alejandro Jiménez Arango

    1987-12-01

    Full Text Available

    Nos corresponde hoy tratar el tema de las micosis y parasitosis del sistema nervioso central en relación con uno de los múltiples síntomas o complejos sindromáticos que pueden ocasionar: la epilepsia, se trata de uno de los síntomas más frecuentes en estas enfermedades y, en general, en las enfermedades encefálicas, y es el resultado de múltiples procesos fisiopatológicos que se producen en el cerebro. Puede la epilepsia ser síntoma de una enfermedad aguda o subaguda, o puede ser una de las secuelas, y a veces la única, de una enfermedad cuyo proceso activo ya ha terminado.

    Con el objeto de buscar cierta coherencia en la presentación del tema, mencionaremos en primer lugar los procesos patológicos, síndromes y lesiones, varios de ellos comunes a muchas micosis y parasitosis, que pueden dar lugar al cuadro epiléptico. En seguida nos referiremos con mayor detalle a cuatro enfermedades o grupos de enfermedades que tienen particular importancia entre nosotros desde el punto de vista clínico y epidemiológico: las micosis, la toxoplasmosis del adulto, el paludismo cerebral y la cisticercosis.

    Como ha sido ampliamente expuesto, las micosis y parasitosis del sistema nervioso central comprenden un gran número de entidades...

  2. Hiperplasia epitelial focal. Tratamiento conservador con ácido tricloroacético: Conservative treatment with trichloroacetic acid

    OpenAIRE

    Harris Ricardo, Jonathan; Vásquez Sanjuán, Katherine; Fortich Mesa, Natalia

    2011-01-01

    La hiperplasia epitelial focal conocida también como enfermedad de Heck es una patología benigna que se caracteriza por la presencia de múltiples pápulas en la mucosa de la cavidad bucal, producida por el virus del papiloma humano afectando principalmente niños y adolescentes. Se reporta caso clínico de paciente femenina de 7 años de edad, remitida por odontopediatría al servicio de estomatología y cirugía oral, por presentar múltiples pápulas en mucosa bucal, de tamaño variable, asintomática...

  3. Eficacia de las relaciones con públicos minoritarios: el caso de la Asociación de Epilepsia de la Provincia de Alicante (AEPA / Effectiveness of minority public relations: the case of the Epilepsy Association of the Province of Alicante (EAPA

    Directory of Open Access Journals (Sweden)

    María Carmen Carreton

    2013-05-01

    Full Text Available ResumenLa Asociación de Epilepsia de la Provincia de Alicante (AEPA implementa su estrategia de relaciones públicas concibiendo a los públicos de la epilepsia como minoritarios. Nuestro objetivo es evidenciar que: la eficacia de AEPA se basa en un cambio de su conducta; conducta reflejada en el diseño, la acción y la comunicación de su estrategia desde la teoría de las relaciones públicas. La aportación de este estudio de caso se centra en el cambio de actitudes y de conducta de los diferentes públicos de la epilepsia en la provincia de Alicante después de la implementación de una estrategia de relaciones públicas basada en los modelos simétricos bidireccionales.AbstractEpilepsy Association of the Province of Alicante (AEPA implements its public relations strategy to designing public and minority epilepsy. Our goal is to show that: AEPA effectiveness is based on a change in his behaviour, conduct reflected in the design, action and communication strategy from the theory of public relations. The contribution of this case study focuses on changing attitudes and behaviour of the different audiences of epilepsy in the province of Alicante after the implementation of a public relations strategybased on two-way symmetrical models.

  4. Aspectos psicosociales de la epilepsia infantil Psychosocial aspects of childhood epilepsy

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    Fernando Sell Salazar

    2009-01-01

    Full Text Available La epilepsia es sin duda una dolencia de las más antiguas y enigmáticas en la historia de la medicina, encontrándose relatos de su existencia desde tiempos remotos. Del oscurantismo ancestral hasta el presente se ha ido avanzando de forma importante en el diagnóstico y el tratamiento científico de la epilepsia. El manejo de un niño con epilepsia debe desarrollarse en el marco de un protocolo que incluya una evaluación clínica y de laboratorio detallada. Toda enfermedad crónica, incluida la epilepsia, es vivida como una doble agresión: 1 Interna, ligada a las alteraciones que ella determina, y 2 Externa, en relación con las exploraciones, las medicinas, las prohibiciones, los cuidados excesivos y todas las reglas y apremios que de ella se derivan. El médico (pediatra, neuropediatra o epileptólogo, al iniciar la relación con el niño con epilepsia, va a dotarle de un nuevo estatuto, frecuentemente duro de asumir, interviniendo por lo general ya lejos de la crisis, o poco después de que ella se produjo, en un ambiente todavía cargado de una gran angustia familiar. Sin duda la epilepsia es difícil para el niño, pero igualmente lo es para los padres, los responsables de un cuidado diferente, quienes se van a preocupar todos los días porque su hijo tome regularmente el tratamiento y van a tener que afrontar la espera tensa de nuevas crisis. Más que cualquier otra enfermedad infantil, la epilepsia implica una gran inquietud por su carácter espectacular, por la aparatosidad de su presentación y por todas las creencias ancestrales que todavía hoy se le atribuyen. Por dichas razones, frecuentemente el diagnóstico de epilepsia produce tres reacciones de gran relevancia en la familia: ansiedad, culpabilidad y agresividad. La intervención del médico en el tratamiento de la epilepsia infantil debe ser "integral". Actuando con mística y devoción el médico debe abrazar el verdadero concepto hipocrático del cuidado del paciente

  5. Genética de las epilepsias Genetics of epilepsy

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    Gustavo A. Charria-Ortiz

    2007-01-01

    Full Text Available En años recientes se ha podido definir con gran exactitud la existencia de alteraciones genéticas específicas en una gran variedad de síndromes epilépticos tradicionales. Es decir, por vez primera se ha podido relacionar de manera contundente y predecible la presencia de alteraciones genómicas y/o proteómicas con síndromes epilépticos antes considerados como "idiopáticos". La gran mayoría de dichos defectos han sido encontrados en genes codificadores para canales iónicos y/o receptores de membrana, lo cual en cierto modo confirma la ya antes postulada relevancia que estas estructuras tienen en la actividad electroquímica espontánea neuronal cuyo desajuste conllevaría a ciertas formas de epilepsia. Esta revisión se centra en los aspectos genéticos y clínicos de dichas condiciones y alteraciones. También se revisarán brevemente los estudios más relevantes de la literatura médica según los cuales -aun a pesar de no haberse definido con la misma exactitud el tipo de anomalías etiológicas- puede tranquilamente inferirse el gran componente genético que parece subyacer a la etiología de las epilepsias. Por ultimo se enfatizará en que a pesar de dichos descubrimientos, su aplicación en la práctica clínica diaria aun es muy limitada, no solo por la relativa rareza de algunos de tales síndromes neurológicos sino también por la poca relevancia que hasta ahora ellos han tenido en el manejo médico rutinario de la mayoría de los pacientes. Las posibilidades inmediatas de tales avances -incluida la farmacogenómica-, así como los posibles conflictos éticos en que se podría incurrir serán también brevemente discutidos.In the last few years, the presence of specific genetic abnormalities leading to some of the classical epileptic syndromes has been clearly elucidated. This means that for the first time, it has become possible to create a strong relationship between the presence of specific genomic and/or proteomic

  6. Indicaciones quirúrgicas de la epilepsia en la niñez Surgical indications in pediatric epilepsy

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    María Isabel Bragatti Winckler

    2007-01-01

    Full Text Available Con el objetivo de presentar el seguimiento de los pacientes ambulatorios de la clínica de epilepsia refractaria del Hospital de Clínicas de Porto Alegre (HCPA, Brasil, se hizo una revisión de la literatura de las epilepsias y síndromes epilépticos del niño y del adolescente, las indicaciones quirúrgicas y los métodos de evaluación. Los casos de epilepsia recomendados por la Subcomisión de Cirugía de la Epilepsia Pediátrica de la Liga Internacional Contra las Epilepsias para evaluación quirúrgica son: displasia cortical, esclerosis tuberosa, polimicrogiria, hamartoma hipotalámico, síndromes hemisféricos, síndromes de Sturge-Weber, Síndrome de Rasmussen, Síndrome de Landau-Kleffner y otras situaciones como tumores o alteraciones vasculares. Se recomienda la formación de centros de referencia que cuenten con métodos de evaluación funcional y de neuroimagen, así como equipo multidisciplinario formado por neurólogos, neurocirujanos, neurofisiólogos, neuropediatras, neuropsicólogos, patólogos, neurorradiólogos y técnicos en electroneurofisiología que mantengan los estándares impuestos de forma estricta. La formación de estos centros en países en desarrollo parece viable, con la cooperación de las regiones con mayores recursos. Numerosos estudios han demostrado una mejoría de la calidad de vida con reducción en la frecuencia de crisis diarias. En el HCPA se desarrolla un estudio de seguimiento ambulatorio de casos de epilepsias refractarias todavía en investigación y tratamiento clínico. La cirugía de la epilepsia es potencialmente curativa y es posible utilizarla en la población infantil.With the goal of presenting follow-up data from patients seen at the Refractory Epilepsy out-patient clinic of the Hospital de Clínicas de Porto Alegre (HCPA, Brazil, we reviewed the literature on childhood and adolescent epilepsy and epileptic syndromes with indication for surgical treatment. The International League

  7. Percepções de pais sobre a epilepsia

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    Maria Silian Mandu Fonseca

    2018-04-01

    Full Text Available Objetivo: comparar o conhecimento que os responsáveis e/ou familiares das crianças diagnosticadas com epilepsia e aquelas com outros diagnósticos possuem em relação a esse distúrbio. Método: este foi um estudo clínico descritivo transversal, que ocorreu através da aplicação da segunda parte do "Inventário Simplificado de Qualidade de Vida na Epilepsia Infantil". Resultados: participaram do estudo 83 indivíduos, sendo 36 do grupo de familiares de crianças com epilepsia e 47 do grupo de crianças com outros diagnósticos. O medo de a língua ser engolida durante uma crise epiléptica está presente em 55,5% dos familiares de crianças com epilepsia e 61,7% dos familiares das crianças do outro grupo. Conclusão: diante disso, é fundamental haver uma política de saúde e educação que envolva capacitação e conscientização sobre a Epilepsia.

  8. Diagnóstico de la epilepsia en la infancia Epilepsy diagnosis present in childhood

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    Nicolás Garófalo Gómez

    2009-06-01

    Full Text Available La epilepsia constituye el trastorno neurológico crónico tratable de mayor frecuencia en la infancia. Su diagnóstico es usualmente fácil, pero en la práctica clínica ocurren errores con relativa frecuencia, al no existir un marcador diagnóstico confiable. En el presente artículo se explica el proceso de diagnóstico de la epilepsia en la infancia, que no depende de un solo factor y que debe estar guiado por la historia clínica como elemento esencial.Epilepsy is the more frequent chronic neurologic disorder easy to treat in childhood. His diagnosis is commonly easy to made but in clinical practice occur relative errors provoked by lack of a reliable diagnosis. In present paper is explained the diagnostic process of epilepsy in childhood, but it not depends of a unique factor and that must to be directed by medical record as an essential element.

  9. Characterization of gold mineralizations of Cuba by means of scanning electron microscopy with X-ray analyzer and con focal Raman microscopy

    International Nuclear Information System (INIS)

    Toledo Sanchez, Carlos Alfredo; Santa Cruz Pacheco, Maria; Lopez Kramer, Jesus M.; Lisabet Sarracen, Evelio; Aguirre Guillot, Graciela; Capote Marrero, Carbeny; Llanes Castro, Angelica I.; Milia Gonzalez, Ines

    2016-01-01

    The technology selection for gold ore processing requires the characterization, not only of the gold carrier minerals but also its associations, so it is necessary to find out the mineral nature, morphology, particle size, purity and gold concentration, other factors to consider are liberation grade, minerals in association, surface accessibility and form to present themselves. In this research it is exposed the utilization of the optical and electron microscopy, with Raman and X ray micro analyzers, in order to obtain useful information about different gold mineralization of the country, including those of Delita, Meloneras-Descanso, Oro Jacinto and Oro Barita. It describes how the scanning electron microscopy with x-ray analyzer allowed the study of gold particles from nanometer order, determining its size, morphology, surface condition and purity. It was found that in some places the gold grains have a purity exceeding 99%, while in others the content of silver, copper and mercury are increasing, surpassing gold just 30% in some cases, resulting in other mineralogical forms. It was also observed variability in the degree of release of the gold particles. Moreover Raman con focal microscope allowed analyzes minerals micrometric volumes under study, particularly rock-forming. Being a structural technique, it was possible to identify minerals without causing damage to the samples, which usually is not achieved with other techniques. (Author)

  10. Correlação entre atrofia hipocampal e déficit de memória em pacientes com epilepsia de lobo temporal mesial

    OpenAIRE

    Denise Pacagnella

    2012-01-01

    Resumo: A Epilepsia de Lobo Temporal Mesial (ELTM) é a forma mais frequente de epilepsia focal em adultos e geralmente está associada à atrofia hipocampal (AH) identificável pela ressonância magnética (RM) de alta resolução. Consiste em uma síndrome frequentemente refratária ao tratamento clínico e os pacientes podem apresentar déficits de memória devido a danos no sistema hipocampal, porém pouco se sabe a respeito do impacto da frequência de crises sobre a memória. Portanto, os objetivos do ...

  11. Acute Porphyria Presenting as Epilepsia Partialis Continua

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    Thi Phuoc Yen Tran

    2013-06-01

    Full Text Available Purpose: The porphyrias are a defect in the biosynthesis of heme which can be associated with different neurological symptoms during acute attacks such as peripheral neuropathy, mental disturbance and seizures. So far, there have only been a few case reports of status epilepticus, none of which were of epilepsia partialis continua (EPC. We present here two cases of hereditary coproporphyria (HCP manifesting EPC as part of the clinical presentation. Method: The patients' medical charts, EEG and imaging studies were carefully reviewed. Results: Case 1 is a 49-year-old male who first presented a tonic-clonic seizure. Case 2 is a 30-year-old male who came to the emergency room for a convulsive status epilepticus. Both evolved to EPC over the next days. EPC persisted despite several antiepileptic drug trials. Diagnosis of HCP was confirmed by a high level of urine, fecal and serum porphyrins in both cases and by genetic testing in one. Over the last 3 years, the first patient has continued to present non-disabling EPC and has had four tonic-clonic seizures associated with alcohol consumption. The second patient died from brain edema one month and half after admission. Conclusion: Acute porphyrias should be included in the differential diagnosis of new onset status epilepticus, including EPC. Their recognition is important as it modifies significantly patient management, since many anticonvulsants are porphyrogenic.

  12. UTILIZACIÓN DEL TELÉFONO MÓVIL PARA EL FOMENTO DE HÁBITOS SALUDABLES EN ADOLESCENTES. ESTUDIO CON GRUPOS FOCALES

    Directory of Open Access Journals (Sweden)

    Carme Carrion

    2016-01-01

    Full Text Available Fundamento: El Proyecto PEGASO pretende diseñar un sistema tecnológico dirigido a adolescentes europeos para fomentar hábitos de vida saludables. El objetivo de este estudio fue explorar las percepciones de adolescentes, sus progenitores y profesores el uso de las tecnologías móviles, la salud y la influencia de las tecnologías en la promoción de estilos de vida saludables en cuanto a alimentación y actividad física. Métodos: Estudio cualitativo basado en datos primarios obtenidos mediante análisis de cuatro grupos focales (tres de adolescentes entre 13 y 15 años y uno de adultos, formado por padres y profesores que se realizaron en abril y mayo de 2015. Las transcripciones se analizaron bajo la perspectiva del análisis del contenido. Resultados: Emergieron cuatro categorías: 1: marco social y cultural, 2: adolescentes y salud, 3: papel de la tecnología en la vida de los adolescentes y 4: uso de la tecnología para adquirir hábitos más saludables. En cada categoría se identificaron subcategorías vinculadas al nexo entre adolescentes y salud: concepto holístico de salud, identificación de salud/enfermedad con edad adulta, relación de la salud con sentirse en buena forma y aceptación social. En relación al papel que juega la tecnología en la vida de los adolescentes, las subcategorías obtenidas fueron: conexión con otros, elemento de entretenimiento/juego, uso omnipresente del móvil y riesgos asociados a la dependencia excesiva de la tecnología. Las diferencias entre adolescentes y adultos fueron mínimas. Conclusiones: Tanto adolescentes como sus progenitores y profesores consideraron que la tecnología puede ser un buen aliado para fomentar hábitos saludables. El uso de la tecnología es eficaz en la medida que les ayude a mejorar y mantener su autoestima, de forma divertida y utilizando sus propios códigos de comunicación (fundamentalmente audiovisuales, partiendo de una percepción holística e integrada de la

  13. Fundación Premio Nacional de Epilepsia “Margaret Merz de Fandiño”

    OpenAIRE

    Jaime Fandiño-Franky

    2009-01-01

    La Fundación se creó para apoyar e incentivar a los investigadores jóvenes colombianos en el estudio de las ciencias del saber relacionadas con la epilepsia.

    Por largos años un grupo de personas naturales y jurídicas han tenido la intención de fomentar entre los jóvenes investigadores colombianos la investigación en las ciencias epileptológicas, ya sea en el aspecto médico, jurídico, de derechos humanos, rehabilitación y en general cualquier rama del saber humano. L...

  14. ANÁLISIS DE SITUACIÓN Y PROPUESTAS DE MEJORA EN ENFERMERÍA DE ATENCIÓN PRIMARIA DE MALLORCA: UN ESTUDIO CON GRUPOS FOCALES

    Directory of Open Access Journals (Sweden)

    Salvadora Sancho Viudes

    2002-01-01

    Full Text Available Fundamento. La reforma de la atención primaria (RAP ha dado lugar a mejoras importantes en la profesión enfermera. Objetivos del estudio: analizar los logros obtenidos por las enfermeras, identificar los problemas que tienen actualmente en atención primaria y proponer líneas de trabajo para el futuro. Método: Investigación cualitativa (técnica del grupo focal. Se realizaron ocho grupos segmentados según la categoría profesional y el puesto desempeñado. Dimensiones de análisis: rol de la enfermera, oferta y organización de servicios, participación y gestión, marketing y formación. Resultados: Para los entrevistados, la RAP ha supuesto una ampliación de las competencias de las enfermeras, aunque su rol sigue sin estar bien definido. Consideran que no existe una cartera de servicios propia de enfermería, a pesar de su claro protagonismo en atención domiciliaria y educación para la salud. Se ha identificado la necesidad de revisar, en términos de resultados, los programas de salud existentes. Se comentan dificultades relacionadas con la falta de ajuste de las plantillas en relación con el incremento poblacional. Destacan problemas de comunicación interna en los equipos y la escasa la difusión de los servicios de enfermería. Se percibe la necesidad de ampliar la formación pregrado en algunos contenidos (educación para la salud y habilidades (trabajo en equipo. Conclusiones: Si bien la RAP ha supuesto mejoras para las enfermeras, quedan aspectos por resolver (definición de cartera de servicios, ajuste de plantillas, comunicación interna, marketing, formación, entre otros y dada la oportunidad que representan las transferencias sanitarias hay que avanzar hacia propuestas innovadoras para mejorar los servicios de salud.

  15. El negativo de la epilepsia: un ejercicio intelectual de ciencia-ficción

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    Fernanda Cerda S.

    2007-01-01

    Full Text Available Históricamente han sido muchos los esfuerzos destinados al estudio y tratamiento de la Epilepsia, entendiéndola de manera general como una manifestación patológica, propia de una enfermedad. Se pretende crear en el presente ensayo un espacio de reflexión destinado a pensar esta admitida “patología” más bien como una función protectora del organismo con un cierto valor biológico. Se aportan argumentos que apuntan a que el cuadro en sí no necesariamente constituye manifestación de muerte, daño o deterioro de funciones a nivel neuronal o cognitivo.

  16. Focal myositis

    International Nuclear Information System (INIS)

    Kransdorf, M.J.; Temple, H.T.; Sweet, D.E.

    1998-01-01

    Focal myositis is a pseudotumor of soft tissue that typically occurs in the deep soft tissue of the extremities, and is a relatively rare lesion. There is a wide clinical spectrum, with approximately one-third of patients with focal myositis subsequently developing polymyositis, and clinical symptoms of generalized weakness, fever, myalgia, and weight loss, with elevation of creatine phosphokinase. We report the case of a patient with focal myositis who subsequently developed myositis ossificans-like features. (orig.)

  17. Epilepsia em um hospital psiquiátrico

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    P. C. Trevisol-Bittencourt

    1990-09-01

    Full Text Available Um recenseamento de epilepsia foi realizado no Hospital Colônia Sant'Ana, a maior instituição psiquiátrica do Estado de Santa Catarina. Este estabelecimento é mantido pela Secretaria de Saúde do Estado e usualmente encontra-se em regime de superlotação, aceitando pacientes sofredores dos mais diferentes tipos de transtornos mentais e provenientes de todas as partes do Estado. Pacientes com epilepsia, apresentando ou não manifestações psiquiátricas, são também freqüentemente internados. Foram identificados 171 pacientes com epilepsia de um total de 1126 internados, dando a alta prevalência de 152/1000. Além destes foram encontrados mais 23 pacientes «disrítmicos cerebrais» em uso de drogas anti-epilépticas sem, entretanto, terem epilepsia. Polifarmácia sedante era o esquema terapêutico adotado na maioria dos pacientes e nomenclatura bizarra era utilizada para definição das crises. Ao menos 85 dos pacientes com epilepsia não apresentavam qualquer justificativa médica para seu confinamento em ambiente psiquiátrico. A utilização exagerada de medicação sedante e a convivência forçada com psicóticos poderiam ser responsabilizadas não só pela persistência das crises mas, também, pelas alterações cognitivas e comportamentais observadas em grande parte dos pacientes. Paradoxal e surrealmente tais «alterações psiquiátricas» justificavam a perpetuação desta pseudoterapia que, ao invés de integrar o paciente na sociedade, o isola em estruturas fechadas. A criação de ambulatórios para abordagem multidisciplinar parece ser a única alternativa frente a essas concepções equivocadas que transformam o geralmente benigno sintoma epilepsia em devastadora doença mental.

  18. Tratamiento Quirúrgico de la Epilepsia Farmacorresistente. 20 años de experiencia de la Fundación Centro Colombiano de Epilepsia y Enfermedades Neurológicas.

    Directory of Open Access Journals (Sweden)

    Ginna de la Rosa-Manjarrez

    2009-07-01

    Full Text Available

    Resumen

    Propósito: Presentar nuestra experiencia y describir las características clínicas, los desafíos quirúrgicos y el resultado de la cirugía de las epilepsias en pacientes adultos y niños.

    Método: Análisis retrospectivo de 552 cirugías de epilepsia realizadas en la Fundación Centro Colombiano de Epilepsia y Enfermedades Neurológicas entre 1989 y 2008, de un total de 750 cirugías.

    Resultados: Desde 1989 hasta 2009 se han realizado 750 cirugías de epilepsia. 552 pacientes, cumplían con todos los criterios de la inclusión para el estudio en mención. Todas las resecciones quirúrgicas fueron realizadas por el mismo neurocirujano (JFF y todos los pacientes ingresaron al mismo protocolo. El control postoperatorio de las crisis tuvo un rango de 30% al 70% dependiendo del tipo de intervención quirúrgica. La morbilidad y la mortalidad estuvieron en el orden del 1%.

    Conclusión: La evaluación de los pacientes con epilepsia medicamente intratable debe estar a cargo de un grupo de especialistas en epilepsia dentro de centro especializado en cirugía de epilepsia. No hay restricciones en la edad para la cirugía de la epilepsia, ni restricciones en relación al síndrome epiléptico y el tipo de intervención. El control de las crisis alcanza porcentajes de éxito hasta del 70% en los pacientes postquirúrgicos, sin embargo es variable si la meta de la cirugía es paliativa o curativa. La rehabilitación es fundamental para la calidad de vida de estos pacientes. Nuestra experiencia fortalece la continuidad de los programas de cirugía de epilepsia.

    Palabras clave: Epilepsia, cirugía.

    Summary

    Object: To present the experience of a center in epilepsy surgery and to describe the clinical characteristics, surgical challenges, and outcome in epilepsy surgery.

    Methods: Retrospective analysis of

  19. Demencia frontotemporal no familiar y epilepsia generalizada Frontotemporal dementia non familial and generalized epilepsy

    Directory of Open Access Journals (Sweden)

    Patricio Fuentes

    2005-12-01

    Full Text Available Se presenta un paciente de 62 años, sin antecedentes familiares de demencia, que a los 45 años debuta con crisis súbitas de disnea, visión borrosa, caída al suelo y movimientos repetitivos de brazos. Tratado por epilepsia con fenitoína y ácido valproico, repite esporádicamente crisis semejantes. Hace 4 años sus familiares notan cambios de personalidad, irritabilidad y conductas obsesivas. Hace 2 años aparecen episodios de desorientación de días de duración, algunos con alucinaciones auditivas y también fenómenos convulsivos. Ultimamente presenta crisis polimorfas, algunas con prolongada alteración de conciencia, estados catatoniformes y relajación esfinteriana. Examen físico y neurológico sin anormalidades. Evaluación neuropsicológica evidenció consistentes defectos en funciones frontales. EEG mostraron lentitud generalizada y actividad irritativa esporádica en regiones frontotemporales. Atrofia cortical de predominio anterior en CT scan e hipoperfusión fronto-temporal bilateral en SPECT. Exámenes de laboratorio y LCR normales. CONCLUSIÓN: La asociación de DFT con epilepsia, en forma no familiar, sugiere un síndrome neurodegenerativo cortical diferente.A 62 year-old patient is presented, without family antecedents of dementia who begins with 45 years of age with sudden crisis of dyspnea, blurred vision, fall to the floor and repetitive jerks of arms. Tried by epilepsy with phenytoin and valproate repeats similar crisis sporadically. Four years ago their relatives began to notice changes of personality, irritability and obsessive behaviors. Later on, are added episodes of disorientation of days of duration, some with auditory hallucinations and also convulsive manifestations. Finally appear polymorphic crisis, some with continue alteration of consciousness, catatonic states and sphincteric incontinence. Physical and neurological examination without abnormalities. Neuropsychological evaluation evidenced consistent

  20. Focal myositis

    International Nuclear Information System (INIS)

    Galloway, H.R.; Dahlstrom, J.E.; Bennett, G.M.

    2001-01-01

    Focal myositis is a rare, benign focal inflammation of muscle. The lesion often presents as a mass that may be mistaken for a soft tissue sarcoma. This report describes the MRI and histopathological features of a case and illustrates how the diagnosis may be suspected on the basis of the MR findings. Copyright (2001) Blackwell Science Pty Ltd

  1. Getting a scientific paper published in Epilepsia: an editor's perspective.

    Science.gov (United States)

    Schwartzkroin, Philip A

    2013-11-01

    Getting a paper published in Epilepsia depends first and foremost on the quality of the work reported, and on the clarity and convincingness of the presentation. Papers should focus on important and interesting topics with clearly stated objectives and goals. The observations and findings are of greatest interest when they are novel and change our views on the mechanisms and/or treatment of an epileptic disease. Studies should be carefully designed to include adequate sample size, comparison groups, and statistical analyses. Critically, the data must be clearly presented and appropriately interpreted. If followed, these recommendations will improve an author's chances of having his/her paper accepted in a high quality journal like Epilepsia. Wiley Periodicals, Inc. © 2013 International League Against Epilepsy.

  2. Tratamento clínico da epilepsia resistente

    Directory of Open Access Journals (Sweden)

    Benito Pereira Damasceno

    1988-12-01

    Full Text Available Foram estudados 34 casos de epilepsia de difícil controle, encaminhados ao Grupo de Trabalho de Epilepsia (GTE do Instituto de Neurologia de Goiânia de 1984 a 1986. Todos eram submetidos a reavaliação neurológica. Vinte e três dos 34 pacientes tinham crises parciais complexas. A maioria foi tratada com carbamazepina, difenil-hidantoína e ácido valpróico, em forma monoterápica ou associada entre si. Obteve-se redução de mais de 80% da freqüência das crises em 22 pacientes (64,7%, além de leve melhora da qualidade de vida. Os autores concluem sobre as vantagens de uma equipe especializada, multidisciplinar, na abordagem da epilepsia rebelde e ressaltam a necessidade de: a. um correto diagnóstico das crises, seguido do uso da medicação apropriada, por tempo suficiente (mínimo de 0 meses e em dose adequada (até a dose máxima tolerável, abandonando-a só depois do controle de sua concentração sérica; b. um bom engajamento do paciente e de sua família no tratamento.

  3. Focal myositis

    Energy Technology Data Exchange (ETDEWEB)

    Kransdorf, M.J. [Saint Mary`s Hospital, Richmond, VA (United States). Dept. of Radiol.]|[Department of Radiologic Pathology, Armed Forces Institute of Pathology, Washington, DC (United States); Temple, H.T. [Department of Orthopedic Surgery, University of Virginia Health Sciences Center, Charlottesville, Virginia (United States)]|[Department of Orthopedic Pathology, Armed Forces Institute of Pathology, Washington, DC (United States); Sweet, D.E. [Department of Orthopedic Pathology, Armed Forces Institute of Pathology, Washington, DC (United States)

    1998-05-01

    Focal myositis is a pseudotumor of soft tissue that typically occurs in the deep soft tissue of the extremities, and is a relatively rare lesion. There is a wide clinical spectrum, with approximately one-third of patients with focal myositis subsequently developing polymyositis, and clinical symptoms of generalized weakness, fever, myalgia, and weight loss, with elevation of creatine phosphokinase. We report the case of a patient with focal myositis who subsequently developed myositis ossificans-like features. (orig.) With 3 figs., 25 refs.

  4. Premio Nacional de Epilepsia “Margaret Merz de Fandiño”.

    Directory of Open Access Journals (Sweden)

    Gustavo Malagón Londoño

    2009-07-01

    Full Text Available

    Este premio, creado con el objetivo de reconocer a los investigadores colombianos comprometidos en el estudio de lo relacionado con las ciencias epileptológicas, es también una manera de estimular al talento humano estudioso y dedicado a aportar su óptimo esfuerzo intelectual para alivio de un padecimiento que afecta directamente a una numerosa población de compatriotas y con ellos impacta a ocho millones de colombianos si contamos la influencia que sobre las familias ejerce esta patología, identificada en 800 mil personas.

    El Premio, aprobado hace dos años en la Asamblea de socios activos de la Liga Colombiana contra la Epilepsia, es una vez más fruto del esfuerzo y tenacidad del Académico Jaime Fandiño Franky, eminente científico de las neurociencias y apóstol de una de las causas que inciden en la situación de los más necesitados en Colombia.

    La labor iniciada por Fandiño Franky hace ya cuatro décadas en la ciudad de Cartagena, con el ánimo de diagnosticar, investigar, tratar, hacer seguimiento y rehabilitación de las víctimas y su entorno familiar, ha llevado a la más ambiciosa realización científica, docente y asistencial, con el montaje primero de una infraestructura física plasmada en un centro de 13.000 metros cuadrados para enfrentar este problema de salud pública, bastante relegado tradicionalmente, pero merecedor por sus proporciones, de una consideración y manejo especiales, que de no prodigarlos el estamento oficial, lo afronta una organización altruista y generosa con Fandiño Franky y Margaret Merz, su esposa, a la cabeza.

    Con el tiempo su organización fue creciendo no sólo física sino cualitativamente con el empleo de las más modernas tecnologías para diagnóstico y tratamiento hasta convertirse en un centro piloto orgullo de Colombia y pionero en Latinoamérica del manejo integral, iniciado con la identificación del paciente y culminado con la rehabilitaci

  5. Epilepsia Ausencias en el Hospital Nacional Cayetano Heredia (1998-2002

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    Iván Espinoza Quinteros

    2004-04-01

    Full Text Available Objetivo: Describir las características clínicas y epidemiológicas de la epilepsia-ausencias en niños en el Hospital Nacional Cayetano Heredia (HNCH. Material y Métodos: Estudio descriptivo-retrospectivo. Se identificaron los pacientes con diagnóstico de ausencias del Servicio de Neuropediatría atendidos desde enero de 1998 hasta diciembre del 2002. Criterios de inclusión: manifestaciones clínicas de ausencias y Electroencefalograma característico. Exclusión: pacientes con lesiones cerebrales. Resultados: Se incluyeron 33 pacientes (6.4% del total. La edad promedio al inicio de enfermedad fue 6.6 años, sexo femenino: 54.5% y tiempo de enfermedad antes del diagnóstico: 12.5 meses. Presentaron antecedente familiar de convulsiones 30.3% y antecedente de eventos perinatales adversos 18.2%. El 39.4% de pacientes presentó ausencias simples y 60.6% ausencias complejas. El 36.4% tuvo inicialmente un patrón electroencefalográfico bilateral asimétrico que posteriormente se tornó simétrico. Todos recibieron ácido valproico pero en 6% se tuvo que cambiar de medicación debido a efectos adversos y 12% tuvieron que recibir terapia combinada por falta de control. Edad, sexo, tipo de crisis, EEG, antecedentes familiares o perinatales, no influyeron en las características clínicas, electroencefalográficas o respuesta terapéutica. Conclusión: Las ausencias representan 6.4% de todas las epilepsias. La edad promedio es de 6.6 años, los antecedentes familiares están presentes en 30.3% de los pacientes y los eventos adversos perinatales en 18.2%. Las ausencias complejas con automatismos son las más frecuentes y el ácido valproico es un tratamiento efectivo. El tiempo de enfermedad antes del diagnóstico fue 12.5 meses por lo cual se recomienda mayor difusión a nivel de padres, educadores y personal de salud para diagnóstico y control oportunos. (Rev Med Hered 2004; 15:89-95.

  6. 100 years of Epilepsia: landmark papers and their influence in neuropsychology and neuropsychiatry.

    Science.gov (United States)

    Hermann, Bruce

    2010-07-01

    As part of the 2009 International League Against Epilepsy (ILAE) Centenary Celebration, a special symposium was dedicated to Epilepsia (100 Years of Epilepsia: Landmark Papers and Their Influence). The Associate Editors were asked to identify a particularly salient and meaningful paper in their areas of expertise. From the content areas of neuropsychology and neuropsychiatry two very interesting papers were identified using quite different ascertainment techniques. One paper addressed the problem of psychosis in temporal lobe epilepsy, whereas the other represents the first paper to appear in Epilepsia presenting quantitative assessment of cognitive status in epilepsy. These two papers are reviewed in detail and placed in historical context.

  7. Procedimento educativo na epilepsia infantil Educational procedure in infantile epilepsy

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    Paula Teixeira Fernandes

    2001-06-01

    Full Text Available A epilepsia é uma condição neurológica crônica que afeta o comportamento do paciente e traz dificuldades psico-sócio-culturais. O trabalho em grupos visa melhorar a interação pais-filhos, através de informações adequadas sobre a epilepsia. O objetivo do presente trabalho foi, através dos grupos de apoio (procedimento educativo, esclarecer aspectos relacionados à epilepsia e avaliar a eficácia destes grupos na identificação e na melhora das variáveis psicológicas. Foram aplicados 36 protocolos (pré e pós-testes que avaliaram sentimentos, crenças e comportamentos dos pais e filhos. Foram observados sentimentos de mágoa e medo, tristeza e rejeição, que foram associados a superproteção e falta de limites. Depois do grupo, 91,6% dos pais relataram ter adquirido mais conhecimento sobre a epilepsia, associando muitas das dificuldades com a falta de informação e a presença de crenças irracionais. Conclui-se que orientação sobre a epilepsia, o uso de medicamentos, os aspectos psicológicos, sociais e comportamentais, melhoram a adaptação à doença. Por isso, a importância dos grupos na desmistificação de crenças, identificação de relações parentais e prevenção de dificuldades comportamentais.Epilepsy is a neurologic disorder, which affects the patient's behaviour and carries strong psychological, social and cultural difficulties. Group-work improves the interaction parent-child, through appropriate explanations regarding the epilepsy. The purpose of this study was to give adequate information about epilepsy through support groups (educational procedure and to assess the efficacy of these groups in identifying psychological aspects. Protocols were applied to 36 parents before and after the sessions, with questions concerning feelings and beliefs about epilepsy as well as parent-child interactions. As the main results, the following feelings were observed: fear, frightening and anxiety, sadness and rejection

  8. Epilepsias mioclónicas en el niño y el adolescente

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    Albia J. Pozo Alonso

    2001-09-01

    Full Text Available Las mioclonías epilépticas son contracciones musculares rápidas originadas por una descarga que proviene del sistema nervioso central y que se identifican por la correlación del electroencefalograma con la sacudida muscular. Las epilepsias mioclónicas son un grupo de síndromes epilépticos que evolucionan exclusiva o preferentemente con crisis mioclónicas. De acuerdo con su causa pueden clasificarse en idiopáticas, sintomáticas y criptogénicas. Según su evolución pueden ser benignas, graves y progresivas. Fue propósito de este trabajo mostrar las características más importantes de algunos de los principales síndromes epilépticos mioclónicos y enfatizar en las manifestaciones clínicas, hallazgos electroencefalográficos y en el tratamiento empleado.The mioclonic epilepsies are rapid muscular contractions originated by a discharge that comes from the central nervous system and that are identified by the correlation of the EEG with the muscular jerk. The mioclonic epilepsies are a group of epileptic syndromes that evolve exclusively or preferably with myoclonic crises. They may be classified as idiopathic, symptomatic or cryptogenic according to their cause. They may be benign, severe or progressive depending on their evolution. The aim of this paper was to show the most important characteristics of some of the main mioclonic epileptic syndromes and to make emphasis on the clinical manifestations, EEG findings and the treatment used.

  9. Ação indesejável de terapêutica antiepiléptica em paciente com epilepsia e descargas focais de "maturação" Undesirable effect of antiepileptic therapy in a patient with functional muturational epilepsy

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    José Geraldo Speciali

    1973-09-01

    Full Text Available É relatada a incidência de epilepsia não convulsiva com características eletrencefalográficas de síndrome de Lennox em paciente de 4 anos de idade tratada com difenilhidantoina. A criança, ao iniciar o tratamento, era acometida por epilepsia convulsiva com atividades paroxísticas focais múltiplas no eletrencefalograma. Com base na observação de formas de transição entre epilepsias benignas e graves da infancia destacou-se o papel da terapêutica no estabelecimento de epilepsia iatrogênica com características malignas.The incidence of non-convulsive epilepsy with electroencephalographic features of Lennox syndrome is related in a 4 years old patient treated with diphenyl-hydantoin. The child had convulsive epilepsy associated with focal multiple spikes in the electroencephalogram at the beginning of the treatment. Based on the observation of transitional forms of benign and severe childhood epilepsies the role of the drug in the establishment of severe yatrogenic epilepsy is discussed.

  10. Avaliação pelo P300 de crianças com e sem epilepsia e rendimento escolar

    OpenAIRE

    VISIOLI-MELO,JUCELEI F.; ROTTA,NEWRA TELLECHEA

    2000-01-01

    Dificuldade de aprendizagem é situação comum em crianças com epilepsia. Distúrbios da inteligência têm sido associados com epilepsia. O potencial cognitivo (P300) é um adjunto clínico para mensurar neurofisiologicamente o processo cognitivo. Foram estudadas 99 crianças com 10 anos a 11 anos e 11 meses. Do Grupo I, sem epilepsia, faziam parte 64 crianças, das quais 32 com bom rendimento e outras 32 com mau rendimento escolar. Do Grupo II, com epilepsia, faziam parte 35 crianças, sendo 21 com b...

  11. Dieta cetogênica no tratamento de epilepsias farmacorresistentes

    OpenAIRE

    Nonino-Borges,Carla Barbosa; Bustamante,Vera Cristina Terra; Rabito,Estela Iraci; Inuzuka,Luciana Midoro; Sakamoto,Américo Ceike; Marchini,Júlio Sérgio

    2004-01-01

    A epilepsia é uma condição clínica crônica correspondente a um grupo de doenças que tem em comum crises epilépticas; ela atinge de 0,5% a 1,0% da população dos países desenvolvidos, podendo esta prevalência ser maior nos países em desenvolvimento. Aproximadamente um terço dos pacientes evolui com crises epilépticas intratáveis com medicamentos; em alguns casos, é possível o tratamento cirúrgico. Nos pacientes em que cirurgia não é possível, a dieta cetogênica passa a ser uma opção terapêutica...

  12. Evidencia molecular y serológica de la asociación del PVH-13 con la hiperplasia epitelial focal en la comunidad indígena embera-chami de Jardín, Antioquia-Colombia

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    Juan Alberto Pérez

    2004-03-01

    Full Text Available

    Introducción: La hiperplasia epitelial focal (HEF o enfermedad de Heck es una entidad benigna de la mucosa oral que se presenta principalmente en jóvenes de grupos étnicos muy específicos. Aunque el epónimo de “Enfermedad de Heck” proviene del primer caso reportado en 1961 por el Dr. Heck en Nuevo Méjico, ya previamente en Colombia el Dr. Estrada en 1956 había reportado esta entidad en los indios Caramanta (1. Es así como en Colombia ha habido reportes de esta enfermedad en diferentes comunidades indígenas (2,3. La hiperplasia epitelial focal se caracteriza clínicamente por pápulas, nódulos o placas localizadas principalmente en la mucosa labial, los carrillos y la lengua.

    Desde 1989 se había sugerido su causa viral debido a la frecuente detección del PVH-13 y PVH-32 en las lesiones (4. En un estudio descriptivo previo realizado en el 2001 se encontró una prevalencia de la enfermedad del 13% en escolares de la comunidad indígena Embera-Chamí en Jardín, Antioquia (5. En ese mismo estudio logramos detectar la infección por PVH en un 80% de escolares con HEF.

    A pesar de que se ha sugerido una etiología viral de la HEF, hasta el momento no existía evidencia epidemiológica que demostrara la asociación del PVH con la hiperplasia epitelial focal. Por tal motivo, el objetivo de este trabajo fue el de confirmar molecular y serológicamente esta asociación. Diseño del estudio: Estudio de casos y controles. Materiales y métodos: La población estudiada de casos correspondió a los escolares que presentaban los criterios clínicos e histopatológicos de HEF. A estos casos se les tomó biopsia de una de las lesiones clínicamente evidentes.

    Papel de la monitorización electroencefalográfica continua en el diagnóstico de la epilepsia pediátrica Role of continuous EEG monitoring in the diagnosis of pediatric epilepsy

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    Agustín Legido

    2009-01-01

    Full Text Available El diagnóstico de la epilepsia es fundamentalmente clínico, pero frecuentemente se plantea el diagnóstico diferencial con fenómenos no epilépticos. El desarrollo de la monitorización EEG continua (MEEGC en las últimas dos décadas ha permitido mejorar el diagnóstico de pacientes epilépticos de todas las edades. En este trabajo se revisan los datos de la literatura sobre la eficacia de los distintos tipos de MEEGC en el diagnóstico de la epilepsia pediátrica, resaltando especialmente nuestra experiencia personal. En nuestros estudios, la MEEGC ambulatoria suplementada con video permitió contestar la pregunta que determinó su petición en el 80% de pacientes diagnosticados de epilepsia y en el 83% de aquéllos con sospecha diagnóstica de epilepsia. Con la MEEGC ambulatoria asistida por ordenador, dichas cifras fueron 88% y 89%, respectivamente y con la MEEGC intrahospitalaria con video fueron 82% y 51%, respectivamente. La MEEGC intrahospitalaria con video es crucial en la evaluación de pacientes con epilepsia, candidatos al tratamiento quirúrgico. La MEEGC es también importante en pacientes con encefalopatías agudas ingresados en las unidades de cuidados intensivos. La MEEGC, tanto ambulatoria como intrahospitalaria, es muy útil en el diagnóstico diferencial de fenómenos clínicos epilépticos y no epilépticos y en la confirmación del tipo de epilepsia o síndrome epiléptico. Los avances tecnológicos y el desarrollo de nuevas modalidades de EEG en el futuro, harán que la electroencefalografía siga siendo una técnica muy importante en el estudio de la función cerebral en pacientes con enfermedades neurológicas agudas o crónicas.The diagnosis of epilepsy is basically clinical, but it frequently raises the differential diagnosis with non-epileptic events. The development of continuous EEG monitoring (CEEGM in the past decades has allowed a better diagnosis of epileptic patients of all ages. In this paper we review the

  13. Recomendaciones para el manejo clínico pediátrico de la dieta cetogénica en el tratamiento de la epilepsia refractaria

    OpenAIRE

    Alberti, María J; Agustinho, Ariela; Argumedo, Laura; Armeno, Marisa; Blanco, Virginia; Bouquet, Cecilia; Cabrera, Analía; Caraballo, Roberto; Caramuta, Luciana; Cresta, Araceli; de Grandis, Elizabeth S; De Martini, Martha G; Diez, Cecilia; Dlugoszewski, Corina; Escobal, Nidia

    2016-01-01

    La dieta cetogénica constituye el tratamiento no farmacológico de eficacia probada más utilizado en la última década para el manejo de la epilepsia refractaria en la población pediátrica. En comparación con el agregado de un nuevo fármaco a un tratamiento preexistente, esta terapia es altamente efectiva, con una reducción de las crisis de entre un 50% y un 90% en aproximadamente 45%-60% de los niños tras 6 meses de tratamiento. Es por ello por lo que la Sociedad Argentina de Neurología Infant...

  14. Insular epilepsy: similarities to temporal lobe epilepsy case report Epilepsia insular: similaridades à epilepsia do lobo temporal - relato de caso

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    ARTHUR CUKIERT

    1998-03-01

    Full Text Available Insular epilepsy has been rarely reported and its clinical and electrographic features are poorly understood. The electrographic study of the insula is difficult since it is hidden from the brain surface by the frontal and temporal lobe. A 48 years-old woman started having simple partial autonomic and complex partial seizures with automatisms and ictal left arm paresis 8 years prior to admission. Seizure's frequency was 1 per week. Pre-operative EEG showed a right temporal lobe focus. Neuropsychological testing disclosed right fronto-temporal dysfunction. MRI showed a right anterior insular cavernous angioma. Intraoperative ECoG obtained after spliting of the sylvian fissure showed independent spiking from the insula and temporal lobe and insular spikes that spread to the temporal lobe. The cavernous angioma and the surrounding gliotic tissue were removed and the temporal lobe was left in place. Post-resection ECoG still disclosed independent temporal and insular spiking with a lower frequency. The patient has been seizure-free since surgery. Insular epilepsy may share many clinical and electroencephalographic features with temporal lobe epilepsy.A epilepsia insular tem sido raramente relatada e suas características clínicas e eletrencefalográficas são pobremente conhecidas. O estudo eletrográfico da ínsula é difícil já que ela se encontra recoberta pelos lobos frontal e temporal. Uma paciente, de 48 anos, começou a ter crises parciais simples autonômicas e crises parciais complexas com automatismos e paresia crítica de membro superior esquerdo 8 anos antes desta internação. A frequência de crises era de 1/semana . O EEG pré-operatório mostrou foco temporal direito. Testagem neuropsicológica demonstrou disfunção fronto-temporal direita. RMN demonstrou cavernoma insular anterior direito. A eletrocorticografia intraoperatória obtida após a abertura da fissura sylviana demonstrou a presença de espículas independentes na

  15. Aspectos genéticos de las epilepsias: una visión actualizada

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    Iscia Lopes-Cendes, M.D., PHD

    2013-11-01

    Full Text Available Es reconocido que los factores genéticos están involucrados en la etiología de diversas epilepsias, sin embargo los genes causales se han logrado identificar principalmente en las epilepsias monogénicas, que representan sólo el 1 a 2% de los síndromes epilépticos. El presente artículo describe algunos de los principales genes identificados hasta el momento en los síndromes mendelianos y no mendelianos. También se hace mención de los principales genes involucrados en la etiología de las malformaciones del desarrollo cortical y de las epilepsias mioclónicas progresivas.

  16. Epilepsia y desarrollo sexual en adolescentes = Epilepsy and sexual development in adolescents

    Directory of Open Access Journals (Sweden)

    Carrizosa Moog, Jaime

    2011-03-01

    Full Text Available Los efectos de las epilepsias y de los fármacos antiepilépticos en el desarrollo sexual de los adolescentes han sido poco estudiados. Las epilepsias per se pueden alterar los ritmos de secreción de las hormonas del eje hipotálamo-hipofisiario y contribuir a que se altere la evolución puberal. Los fármacos antiepilépticos pueden afectar la talla en ambos sexos y producir cambios en el tamaño testicular y en la longitud del pene. En las mujeres adolescentes existen los riesgos del síndrome de ovario poliquístico y de la epilepsia catamenial. En los hombres se pueden afectar la fertilidad y el desempeño sexual. Es necesario hacer más estudios sobre este asunto, que incluyan los efectos de los nuevos medicamentos anticonvulsivantes.

  17. El tratamiento de la epilepsia en la agenda de los medios para una comunicación afirmativa/ The treatment of epilepsy in the media agenda to an affirmative communication

    Directory of Open Access Journals (Sweden)

    Ángeles Feliu Albadalejo

    2011-11-01

    Full Text Available La cifra de personas que padecen epilepsia en España alcanza, según últimos datospublicados, los 400.000. Si bien cada año se diagnostican 20.000 casos nuevos en nuestropaís, la epilepsia es la gran desconocida de las enfermedades por la sociedad. Las personasafectadas y sus familias conviven con una enfermedad que incapacita, en muchas ocasiones,al paciente en su actividad diaria. Es, en este aspecto, donde la morbilidad que rodea a laepilepsia es casi más perjudicial para los enfermos y familiares que la propia enfermedadque ha sido reconocida por la Organización Mundial de la Salud como “un importanteproblema de salud pública”. El actual trabajo, a partir del análisis de contenido de 159noticias aparecidas en diferentes soportes on line, presenta cómo tratan la epilepsia losmedios de comunicación y su impacto en la agenda de los públicos, así como los temas y el contexto de las noticias sobre la epilepsia en función de la clasificación de públicos queaportamos y que está basada en la Teoría Situacional de Grunig. El logro de estos objetivos,nos ha permitido conocer el grado de sensibilización de la epilepsia a partir del contenido delas noticias por tipo de público y la necesidad de que los medios de comunicación hagan deprescriptores e influenciadores con los actores políticos, para una comunicación afirmativa. /The number of people with epilepsy in Spain reaches, according to latest data, 400,000.While each year there are 20,000 new cases diagnosed in our country, epilepsy is the greatunknown by society. Affected individuals and their families living with a disease, in manycases, invalidating the patient in daily activities. It is in this aspect, where morbiditysurrounding epilepsy is almost more damaging to patients and their families to the diseaseitself, has been recognized by the World Health Organization as "an important public healthproblem." The present work, a content analysis of 159 reports in different

  18. Epilepsia e ordem de nascimento Epilepsy and birth order

    Directory of Open Access Journals (Sweden)

    Paulo Cesar Sandler

    1975-09-01

    Full Text Available Mediante o método de Greenwood-Yule e o teste estatístico mais sensível de que se dispõe atualmente, o x² de Halperin, foi testada a possível associação entre a prevalência de epilepsia e a ordem de nascimento de 238 pacientes. Estes pacientes foram obtidos em dois hospitais de São Paulo, na tentativa de se controlar sua classe social; tratava-se de epilépticos com variados transtornos psiquiátricos. Concluiu-se por uma associação estatisticamente significante entre a doença e a ordem de nascimento dos 238 pacientes, com uma sobre-representação nos primeiros e nos últimos nascidos.This paper deals with birth order and epilepsy. The Greenwood-Yule's method was applied, with the most powerful statistical test available, Halperin's modified chi-square. The authors concluded that there is a consistent positive association between this illness prevalence and birth order of the patients, being first and last born over-represented, irrespective of their sibship size. The data were obtained in two psychiatric hospitals in the city of São Paulo, being social class factor qualitatively controlled. All the 238 patients studied suffered a wide range of psychiatric symptoms.

  19. Perfil neuropsicológico em doentes com epilepsia do lobo temporal

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    Daniela Marques

    2013-01-01

    Full Text Available A epilepsia do lobo temporal (ELT é o tipo de epilepsia refractária mais comum nos adultos. Existe um consenso quanto ao compromisso da memória na ELT com esclerose hipocampal. Contudo, no que respeita a outras funções como é o caso da atenção, funções executivas, rendimento intelectual e linguagem, o consenso não é tão generalizado. Para este estudo analisámos retrospectivamente um grupo de 76 doentes com epilepsia refractária, 48 doentes com epilepsia do lobo temporal (23 com lateralização à direita e 25 com lateralização à esquerda e 28 doentes com epilepsia extratemporal. Aplicámos uma batería de provas utilizada no âmbito do programa da Cirurgia da Epilepsia do Hospital de Egas Moniz em Lisboa, Portugal. Os resultados mostram que a bateria aplicada apresenta consistência interna no âmbito da avaliação dos doentes com ELT. Encontrámos que os doentes com ELT apresentam um padrão generalizados de défices, o que pode ser indicativo de compromisso noutras áreas, para além do hipocampo. Um achado que consideramos pertinente foi o facto da memória verbal com interferência (memoria a longo termo se manter adequada, sugerindo que esta função não está comprometida na ELT. Em suma, para além do padrão generalizado de défices cognitivos, também conseguimos observar o impacto da doença ao nível das variáveis sociodemográficas, assim como establecer uma relação com os achados neurobiológicos anteriormente descritos na literatura.

  1. Comorbidities associated with epilepsy and headaches Comorbidades associadas às epilepsias e cefaleias

    Directory of Open Access Journals (Sweden)

    Thalles P. Ferreira

    2012-04-01

    Full Text Available Comorbidities are often associated with chronic neurological diseases, such as headache and epilepsy. OBJECTIVES: To identify comorbidities associated with epilepsy and headaches, and to determine possible drug interactions. METHODS: A standardized questionnaire with information about type of epilepsy/headache, medical history, and medication was administered to 80 adult subjects (40 with epilepsy and 40 with chronic headache. RESULTS: Patients with epilepsy had an average of two comorbidities and those with headache of three. For both groups, hypertension was the most prevalent. On average, patients with epilepsy were taking two antiepileptic medications and those with headache were taking only one prophylactic medication. Regarding concomitant medications, patients with epilepsy were in use, on average, of one drug and patients with headache of two. CONCLUSIONS: Patients with chronic neurological diseases, such as epilepsy and headaches, have a high number of comorbidities and they use many medications. This may contribute to poor adherence and interactions between different medications.As comorbidades geralmente estão associadas a doenças neurológicas crônicas, tais como cefaleia e epilepsia. OBJETIVOS: Identificar comorbidades associadas à epilepsia e cefaleia e determinar as possíveis interações de drogas. MÉTODOS: Questionário padronizado com informações sobre o tipo de epilepsia/cefaleia, os antecedentes médicos e as medicações foi aplicado a 80 indivíduos adultos (40 com epilepsia e 40 com cefaleia crônica. RESULTADOS: Pacientes com epilepsia e cefaleia apresentaram uma média de duas e três comorbidades, respectivamente, sendo, para ambos, hipertensão arterial sistêmica a mais prevalente. Em média, os pacientes com epilepsia estavam em uso de duas medicações antiepilépticas; aqueles com cefaleia, uma medicação profilática. Em relação às medicações concomitantes, os pacientes com epilepsia estavam em uso

  2. Epilepsia y conducción vehicular en Argentina: Una nueva propuesta

    Directory of Open Access Journals (Sweden)

    I. Casas Parera

    2003-06-01

    Full Text Available En diversos países del mundo existen reglamentaciones sobre epilepsia y conducción vehicular (CV. En Argentina, poseemos la Ley Nº 24.449 y el Decreto Reglamentario Nº 779/95, que en su art. 33 sobre Criterios de Aptitud Física menciona la epilepsia y el electroencefalograma anormal, y los Códigos NE02 y NE03 que califican de «INEPTO» a quien le corresponda uno u otro. De la revisión bibliográfica y las reglamentaciones vigentes en otros países y el nuestro proponemos: 1 Deberán constar en la historia clínica las recomendaciones del médico tratante acerca de la enfermedad y CV. 2 Tomar el período igual o mayor a 1 año libre de crisis como indispensable para levantar la restricción de CV. 3 La obligación de presentar certificado anual del control neurológico y de medicación antiepiléptica. 4 La restricción de CV a aquéllos en cambio de medicación y/o supresión de la misma, durante ese período y terminado el proceso, por otros 6 meses. 5 Que no sea obligatoria la denuncia de la enfermedad ante las autoridades por parte del médico. 6 En el apartado «Criterios de Aptitud Neurológica», en los Códigos NE02 y NE03 deberán modificarse los conceptos «INEPTO» por el de «EVALUAR». 7 No se autorizará a personas con antecedentes de crisis epilépticas o con epilepsia, la conducción de camiones para comercio interprovincial, ómnibus de transporte público y escolares. Creemos que estas medidas: 1 Favorecerán la denuncia espontánea de la enfermedad por parte del solicitante de la licencia de conductor. 2 Mejorarán el control clínico/neurológico de estos pacientes. 3 Se evitarán accidentes y daños a la propiedad. 4 Actualizan la ley y reglamentación vigentes. 5 Por la implicancia médico-legal-social del tema, resguardan: a al médico sobre eventuales acciones judiciales, b asimismo protegen al paciente sobre eventuales acciones judiciales, c aumentarán la seguridad vial beneficiando a nuestra comunidad

  3. Apoplejía, Convulsiones, Epilepsia, Heteroplasmia, MELAS, Migraña, Mutación, mtDNA Comportamiento de la mutación mtDNA A3243G en dos familias antioqueñas de pacientes diagnosticados con el síndrome MELAS

    Directory of Open Access Journals (Sweden)

    Gabriel Bedoya Berrío

    2010-02-01

    -layout-grid-align: none;">Conclusions: Severity of the symptoms in patients affected with MELAS is correlated with the amount of MDNA. Furthermore, it was found a correlation between MDNA and IAA, suggesting a possible effect of amerind nuclear ontext in The mitochondrial

    segregation and replication.

    Introducción: mutaciones en mtDNA causan citopatias mitocondriales, la más común de ellas es el síndrome MELAS; la transición A3243G en tRNA de leucina (tRNALeu se presenta en 80% de pacientes. La heteroplasmia, observada en citopatias mitocondriales, consiste en coexistencia de moléculas mutadas y normales en una célula, situación en la cual, dependiendo de su cantidad, afecta su función con expresión clínica variable.

    Objetivo: evaluar el comportamiento de la cantidad de heteroplasmia de la mutación 3243G en su expresión clínica y en la dependencia de variantes nucleares.

    Teachers perception about epilepsy Percepção de professores sobre epilepsia

    Directory of Open Access Journals (Sweden)

    Paula T. Fernandes

    2007-06-01

    percepção dos professores do ensino fundamental a respeito da epilepsia, antes e depois de um curso específico sobre o tema. MÉTODO: Participaram da pesquisa professores de nove escolas da rede pública do ensino fundamental de Barão Geraldo, distrito de Campinas, SP. Dois pesquisadores reuniram-se com os professores e apresentaram a Campanha Global "Epilepsia fora das sombras", momento também em que os questionários foram aplicados. Vinte professores ficaram motivados para fazer o curso de extensão "Temas transversais: epilepsia e saúde". Após este curso, os questionários foram re-aplicados. RESULTADOS: Foram aplicados 100 questionários em professores das nove escolas, sendo que: noventa e sete professores eram do sexo feminino, idade média de 42 (D.P. 22 a 63 e 64 estavam casados. Quarenta e três professores declararam possuir conhecimento sobre epilepsia abaixo da média e 20, disseram possuir um pobre conhecimento sobre a condição. No que diz respeito à idéias sobre epilepsia, os professores acham que: as crianças com epilepsia tem QI igual (45%, na média (18%, abaixo da média (6% e não sabem opinar (29%; crianças com epilepsia têm maior chance de terem doença mental no futuro (51%; a epilepsia é uma doença (68%; a epilepsia é contagiosa (1%; a epilepsia é tratável (90%. Após o curso, crenças e mitos sobre epilepsia dos professores mostraram diferenças significativas. DISCUSSÃO: Idéias errôneas sobre epilepsia podem ser mudadas através de cursos educacionais sobre epilepsia. Este trabalho, realizado com professores do ensino fundamental, visou a identificação das dificuldades relacionadas à epilepsia para promover a redução do estigma. É importante que professores sejam melhor instruídos sobre a epilepsia para consequentemente, ter atitudes mais positivas em relação às crianças com epilepsia. Acreditamos que professores mais capacitados melhoram a maneira de lidar e de se relacionar com crianças com epilepsia, para a

  4. Genes e epilepsia I: epilepsia e alterações genéticas Genes and epilepsy I: epilepsy and genetic alterations

    Directory of Open Access Journals (Sweden)

    Daniel L. G. Gitaí

    2008-06-01

    Full Text Available INTRODUÇÃO: Epilepsia é uma desordem neurológica caracterizada por crises espontâneas e recorrentes, que afeta de 2% a 3 % da população mundial. As crises epilépticas refletem atividade elétrica anormal e paroxística, preferencialmente em uma ou várias áreas do córtex cerebral, que podem ser causadas por inúmeras patologias estruturais ou neuroquímicas. Dentre os importantes estudos das últimas décadas no campo da epileptologia, destaca-se a identificação de genes associados a certos tipos de epilepsia. OBJETIVO: Nesta revisão, descrevemos as principais alterações genéticas associadas ao processo epileptogênico, discutindo as mais recentes descobertas e suas contribuições para a compreensão das bases genéticas das epilepsias idiopáticas monogênicas (EIM e das epilepsias geneticamente complexas. RESULTADOS E CONCLUSÃO: Estudos de ligação e associação mostram que alterações em genes que codificam canais iônicos são as principais causas genéticas das epilepsias idiopáticas monogênicas e de predisposição nas epilepsias geneticamente complexas. Além disso, as síndromes nas quais a epilepsia é um aspecto importante do quadro clínico podem ser provocadas por genes envolvidos em diferentes vias celulares, tais como: migração neuronal, metabolismo de glicogênio e cadeia respiratória. Portanto, acredita-se que diferentes categorias de genes possam atuar na determinação do traço epiléptico. A identificação de tais famílias de genes não apenas nos ajudará a entender as vias moleculares associadas à hiperexcitabilidade neuronal e ao processo epileptogênico, mas também poderá conduzir ao desenvolvimento de novas e mais precisas estratégias de tratamento da epilepsia.INTRODUCTION: Epilepsy is a neurological disorder characterized by spontaneous and recurrent seizures with an estimated prevalence of 2-3 % in the world population. Epileptic seizures are the result of paroxystic and

  5. Análisis de situación y propuestas de mejora en enfermería de atención primaria de Mallorca: un estudio con grupos focales

    Directory of Open Access Journals (Sweden)

    Sancho Viudes Salvadora

    2002-01-01

    Full Text Available Fundamento. La reforma de la atención primaria (RAP ha dado lugar a mejoras importantes en la profesión enfermera. Objetivos del estudio: analizar los logros obtenidos por las enfermeras, identificar los problemas que tienen actualmente en atención primaria y proponer líneas de trabajo para el futuro. Método: Investigación cualitativa (técnica del grupo focal. Se realizaron ocho grupos segmentados según la categoría profesional y el puesto desempeñado. Dimensiones de análisis: rol de la enfermera, oferta y organización de servicios, participación y gestión, marketing y formación. Resultados: Para los entrevistados, la RAP ha supuesto una ampliación de las competencias de las enfermeras, aunque su rol sigue sin estar bien definido. Consideran que no existe una cartera de servicios propia de enfermería, a pesar de su claro protagonismo en atención domiciliaria y educación para la salud. Se ha identificado la necesidad de revisar, en términos de resultados, los programas de salud existentes. Se comentan dificultades relacionadas con la falta de ajuste de las plantillas en relación con el incremento poblacional. Destacan problemas de comunicación interna en los equipos y la escasa la difusión de los servicios de enfermería. Se percibe la necesidad de ampliar la formación pregrado en algunos contenidos (educación para la salud y habilidades (trabajo en equipo. Conclusiones: Si bien la RAP ha supuesto mejoras para las enfermeras, quedan aspectos por resolver (definición de cartera de servicios, ajuste de plantillas, comunicación interna, marketing, formación, entre otros y dada la oportunidad que representan las transferencias sanitarias hay que avanzar hacia propuestas innovadoras para mejorar los servicios de salud.

  6. Epilepsia temporal: relato de caso = Temporal epilepsy: case report

    Directory of Open Access Journals (Sweden)

    Souza, Taís Amara da Costa de

    2006-01-01

    Full Text Available Este trabalho tem o objetivo de divulgar um recurso terapêutico da epilepsia do lobo temporal por esclerose hipocampal: a cirurgia. Aproximadamente vinte e cinco mil pacientes com esta patologia são refratários aos tratamentos medicamentosos no sul do país e muitos chegam ao neurocirurgião com 30-40 anos de evolução, muitas vezes já mutilados em conseqüência das crises. Convulsões parciais originadas no lobo temporal são comuns, e grande parte originam-se em estruturas mesiais (esclerose mesial temporal – EMT. Como aí se encontram a sede de funções nobres do sistema nervoso – memória, aprendizagem, comportamento, entre outras –, os sintomas podem apresentar-se como alterações em qualquer uma delas. Ressaltamos a necessidade do correto diagnóstico e dos métodos para fazê-lo: através da anamnese, da ressonância magnética, do eletroencefalograma (EEG, do vídeo-EEG e por vezes através de sensores intracranianos (strips. Apesar de existirem métodos confiáveis para realizar o diagnóstico e tratamento cirúrgico com grande índice de sucesso, a desinformação dos profissionais que atendem pacientes com EMT acerca do assunto leva ao prolongamento de tratamentos clínico ineficiente e conseqüente seqüelas físicas, psicológicas e sociais

  7. From the editors: Epilepsia's 2014 Operational Definition of Epilepsy survey.

    Science.gov (United States)

    Mathern, Gary W; Beninsig, Laurie; Nehlig, Astrid

    2014-11-01

    From March 19 to June 30, 2014, Epilepsia conducted an open access online survey asking directed questions related to the 2014 Operational Definition of Epilepsy. This study reports the findings of that poll. The survey consisted of seven questions. Three questions addressed: (1) Criteria for when a person could be considered to have epilepsy after a single seizure; (2) if individuals with reflex seizures (unprovoked) have epilepsy; and (3) when epilepsy could be considered "resolved." Four added questions asked if responders were medical personal compared with patients and family members, geographic region of residence based on International League Against Epilepsy (ILAE) regions, and if responders had read the paper and if they were ILAE/International Bureau for Epilepsy (IBE) members. Of 476 that started the survey, 324 (68%) completed it. As recommended in the ILAE report, 43% agreed that if the chance of a second seizure after a first one was 61-90%, then a person could be considered to have epilepsy. More medical professionals agreed with the 61-90% criteria (55%) compared with patients (21%), while more patients indicated that epilepsy should only be defined after two unprovoked seizures (51%) compared with medical professionals (21%; p < 0.0001). The majority indicated that reflex seizures qualify a person as having epilepsy (79%). As recommended in the ILAE report, 51% agreed that the definition of a person with "resolved" epilepsy would be 10 years seizure-free and off medication for the last 5 years. More medical professionals agreed with this definition (59%) compared with patients (37%), while more patients indicated that epilepsy is never resolved (32%) compared with medical professionals (7%; p < 0.0001). There were no differences based on geographic residence. This survey found that the ILAE recommendations had the highest responses. However, there was clear disagreement with identified differences comparing medical personal with patients

  8. Epilepsia e doença de chagas cronica

    Directory of Open Access Journals (Sweden)

    Edymar Jardim

    1981-03-01

    Full Text Available A síndrome epiléptica em chagásicos crônicos, foi referida raramente na literatura especializazda, não tendo sido feito até o momento, um estudo detalhado das suas manifestações. Partindo-se da premissa de que a moléstia de Chagas tem por substrato anatômico uma destruição neuronal, procurou-se comparar dois grupos de epilépticos, um dos quais com moléstia de Chagas crônica. Foram estudados 167 pacientes epilépticos, dos quais 44 eram comprovadamente chagásicos. O estudo permitiu coletar dados referentes à procedência dos pacientes, resultado soro-lógico, sexo, idade, época de incidência das manifestações epilépticas, elementos dos exames neurológicos, do líquido cefalorraqueano, eletrencefalográfico e os resultados da terapêutica anticonvulsivante. Como resultados principais destacamos o início tardio da epilepsia nos chagásicos, e o predomínio acentuado das crises parciais com sintomatologia elementar de tipo autonômico. O exame neurológico e o do líquido cefalorraqueano, apesar de apresentarem percentualmente nos seus resultados, taxas moderadamente mais elevadas na incidência de alterações, não caracterizaram síndromes neurológicas bem definidas. O exame eletrencefalográfico, revelou alterações sugestivas de comprometimento orgânico cerebral difuso. A terapêutica anticonvulsivante, baseada na utilização de hidantoinatos, barbitúricos, primidona e benzodiazepínicos, mostrou que o controle das crises foi mais difícil nos chagásicos, exigindo maiores quantidades de medicação, com resultados menos satisfatórios.

  9. Estrategias para mejorar la visualización de lesiones en pacientes con epilepsia refractaria

    Directory of Open Access Journals (Sweden)

    Dr. Gálvez M. Marcelo

    2013-11-01

    Las imágenes durante la cirugía permiten la integración de toda la información, que puede ser de ayuda para la determinación de los límites de la resección y localización de las áreas elocuentes. La ecografía intraoperatoria muchas veces es muy útil para determinar la extensión de las lesiones.

  10. Estudio preliminar de la profilaxis de la epilepsia en acúmulos, con midazolam.

    OpenAIRE

    Paredes L., Gustavo A.; Andrade, M.; Vielma, Marly; Rondón, Juana

    2006-01-01

    Editorial. ¡Ya tenemos símbolo, ícono o logotipo!. Now we have symbol, icono or logo!. Salinas, Pedro José Accidentes domésticos en ancianos. Municipio Libertador. Mérida. 1993-1996. Domestics accidents in elderly people. Libertador County of Mérida State. 1993-1996. Salinas, Pedro José Rojas Márquez, Reina Estrés y síntomas en personal de salud del Hospital Universitario de Los Andes. Stress and symptoms in health staff of the Hospital Universitario de Los Andes. Méri...

  11. Epilepsia e arte: relação, interação ou conseqüência = Epilepsy and art: relation, interaction or consequence

    Directory of Open Access Journals (Sweden)

    Khan, Richard Lester

    2005-01-01

    Full Text Available Objetivo: Este artigo tem como objetivo revisar estudos envolvendo epilepsia e arte, mostrando o sofrimento, alegria, criações e adversidades destes com a epilepsia. Métodos: Revisão bibliográfica (Medline, Lilacs, selecionando aspectos sobre epilepsia e arte. Conclusão: O texto discorre sobre a vida e obras de grandes nomes da arte que tiveram suas vidas marcadas e influenciadas pela epilepsia; e suas manifestações sociais, psíquicas e físicas

  12. Lateralização da área epileptogênica através de ressonância magnética na epilepsia do lobo temporal

    Directory of Open Access Journals (Sweden)

    M.C. Sandmann

    1994-09-01

    Full Text Available Métodos especiais de MRI foram utilizados em 5 pacientes com epilepsia do lobo temporal refratários ao tratamento clínico, com a finalidade de localizar a área epileptogênica. Imagens coronais com espessura de 5 mm foram obtidas da borda posterior do tronco cerebral até a base do lobo frontal, utilizando-se as sequências "Inversion Recovery T1" (TR=2500 msec, TE=26 msec, TI=600 msec para avaliar perda de estrutura interna e atrofia do hipocampo e morfologia do lobo temporal; Spin-echo T2w (TR=2500 msec, TE=120 msec visando a avaliar sinais de alta intensidade anormais. Em 2 casos com focos esquerdos no EEG, a MRI mostrou atrofia, perda de estrutura interna e aumento de sinal no hipocampo, e atrofia do lobo temporal anterior, ipsilateralmente. Um caso com focos bilaterais independentes no EEG teve atrofia, perda da estrutura interna e aumento de sinal no hipocampo direito. Um caso com EEG focal direito mostrou atrofia em ambos os lobos temporais anteriores. Outro caso não mostrou anormalidades. Concluimos que esta metodologia pode facilitar a indicação cirúrgica em epilepsia do lobo temporal.

  13. Consideraciones quirúrgicas propias de la epilepsia en niños

    Directory of Open Access Journals (Sweden)

    Dr. Campos P. Manuel

    2013-11-01

    Entre el 25 al 33% de los niños presentan epilepsias resistentes a fármacos y la mitad de ellos son candidatos para iniciar un estudio prequirúrgico. En Chile, aproximadamente 347 niños al año necesitarían cirugía, pero no se operan más de 50 casos al año. Si a esto agregamos los casos rezagados de los años anteriores, significa que hay miles de niños que esperan por una cirugía de la epilepsia. Este artículo revisa el estado del arte actual.

  14. Epilepsia partialis continua Kozevnikov. Correlation of cranial computertomography and EEG-findings

    Energy Technology Data Exchange (ETDEWEB)

    Lipinski, C.G.

    1982-10-01

    Two children with onset of epilepsia partialis continua (Epc) in the age of 8 years are described. EEG-findings and cranial computertomography are compared. Were as the CAT is demonstrating the underlaying morphological lesion of Epc, the EEG is showing the epileptic phenomena. Both, anatomic lesion and electronencephalographic focus can show quite different localisations. Despite this findings, to establish the diagnosis Epc, in our cases the computertomographic proof of a cortical and subcortical lesion seems to be important.

  15. Transtornos psiquiátricos associados à epilepsia Psychiatric disorders associated to epilepsy

    Directory of Open Access Journals (Sweden)

    Juliana de Oliveira

    2003-01-01

    Full Text Available Os autores relatam caso de uma paciente portadora de epilepsia que desenvolveu sintomas psicóticos e depressivos associados a essa patologia, discutindo-o em relação a seus aspectos psicopatológicos.The authors report a case of a patient with epilepsy who developed psychotic and depressive symptons and discuss it in the light of psychopatological aspects.

  16. Epilepsia partialis continua Kozevnikov. Correlation of cranial computertomography and EEG-findings

    International Nuclear Information System (INIS)

    Lipinski, C.G.

    1982-01-01

    Two children with onset of epilepsia partialis continua (Epc) in the age of 8 years are described. EEG-findings and cranial computertomography are compared. Were as the CAT is demonstrating the underlaying morphological lesion of Epc, the EEG is showing the epileptic phenomena. Both, anatomic lesion and electronencephalographic focus can show quite different localisations. Despite this findings, to establish the diagnosis Epc, in our cases the computertomographic proof of a cortical and subcortical lesion seems to be important. (orig.) [de

  17. Clinical course and variability of non-Rasmussen, nonstroke motor and sensory epilepsia partialis continua: a European survey and analysis of 65 cases

    DEFF Research Database (Denmark)

    Mameniskiene, Ruta; Bast, Thomas; Bentes, Carla

    2011-01-01

    To gain new insights into the clinical presentation, causes, treatment and prognosis of epilepsia partialis continua (EPC), and to develop hypotheses to be tested in a prospective investigation.......To gain new insights into the clinical presentation, causes, treatment and prognosis of epilepsia partialis continua (EPC), and to develop hypotheses to be tested in a prospective investigation....

  18. Epilepsia e Gravidez: Evolução e Repercussões

    Directory of Open Access Journals (Sweden)

    Lorenzato Roberta Zago

    2002-01-01

    Full Text Available Objetivo: avaliar a evolução da epilepsia durante a gestação e a ocorrência de malformações nos recém-nascidos de mães epilépticas, que usaram drogas anticonvulsivantes durante a gestação. Avaliar as características perinatais relacionadas ao peso ao nascer e Apgar dos recém-nascidos. Métodos: foram analisados 126 prontuários de pacientes epilépticas atendidas no Ambulatório de Gestação de Alto Risco do Departamento de Ginecologia e Obstetrícia HC-FMRP-USP. Por meio da pesquisa de prontuário foram avaliadas as seguintes variáveis: idade, paridade, diagnóstico quanto ao tipo de crise epiléptica, droga anticonvulsivante usada durante o pré-natal, evolução das crises epilépticas durante o pré-natal, tipo de parto e idade gestacional na resolução e caraterísticas perinatais dos recém-nascidos. Foram excluídas da avaliação de evolução da epilepsia durante a gravidez as pacientes que não freqüentaram o pré-natal do HC-FMRP-USP. Resultados: a porcentagem de gestantes portadoras de epilepsia neste estudo foi de 0,2% em relação às pacientes em seguimento no pré-natal no HC-RP. A epilepsia parcial simples foi o tipo mais freqüente, com 40% casos. No tratamento, a monoterapia esteve presente em 75% dos casos e a carbamazepina foi a droga mais utilizada. Das pacientes que puderam ser avaliadas (111 gestantes quanto à evolução da doença durante a gravidez, 53% não sofreram modificação, 31% pioraram e 16% apresentaram melhora. O parto normal foi realizado em 62,5% dos casos, com resultado perinatal satisfatório na avaliação do índice de Apgar e com taxa de recém-nascido de baixo peso acima dos valores de populações de baixo risco. Não foram observadas malformações fetais. Conclusões: a epilepsia apresentou evolução favorável durante a gestação, não tendo sido agravada pela mesma; os casos em que houve piora do quadro são associados com epilepsia de difícil controle antes da gestação. A

  19. Focal neuronal loss, reversible subcortical focal T2 hypointensity in seizures with a nonketotic hyperglycemic hyperosmolar state

    International Nuclear Information System (INIS)

    Raghavendra, S.; Ashalatha, R.; Thomas, Sanjeev V.; Kesavadas, C.

    2007-01-01

    Neuroimaging in seizures associated with nonketotic hyperglycemia (NKH) is considered normal. We report magnetic resonance imaging (MRI) abnormalities in four patients with NKH and seizures. We prospectively evaluated clinical and radiological abnormalities in four patients with NKH during the period March 2004 to December 2005. All patients presented with seizures, either simple or complex partial seizures or epilepsia partialis continua. Two of them had transient hemianopia. MRI showed subcortical T2 hypointensity in the occipital white matter and in or around the central sulcus (two patients each), T2 hyperintensity of the overlying cortex (two patients), focal overlying cortical enhancement (three patients) and bilateral striatal hyperintensity (one patient). Diffusion-weighted imaging (DWI) performed in three patients showed restricted diffusion. The ictal semiology and electroencephalographic (EEG) findings correlated with the MRI abnormalities. On clinical recovery, the subcortical T2 hypointensity and striatal hyperintensity reversed in all patients. The initial cortical change evolved to FLAIR hyperintensity suggestive of focal cortical gliosis. The radiological differential diagnosis considered initially included encephalitis, malignancy and hemorrhagic infarct rendering a diagnostic dilemma. We identified subcortical T2 hypointensity rather than hyperintensity as a characteristic feature of seizures associated with NKH. Only very few similar reports exist in literature. Reversible bilateral striatal T2 hyperintensity in NKH has not been reported to the best of our knowledge. (orig.)

  1. Focal neuronal loss, reversible subcortical focal T2 hypointensity in seizures with a nonketotic hyperglycemic hyperosmolar state

    Energy Technology Data Exchange (ETDEWEB)

    Raghavendra, S.; Ashalatha, R.; Thomas, Sanjeev V. [Sree Chitra Tirunal Institute for Medical Sciences and Technology, Department of Neurology, Trivandrum, Kerala (India); Kesavadas, C. [Sree Chitra Tirunal Institute for Medical Sciences and Technology, Department of Imaging Sciences and Interventional Radiology, Trivandrum (India)

    2007-04-15

    Neuroimaging in seizures associated with nonketotic hyperglycemia (NKH) is considered normal. We report magnetic resonance imaging (MRI) abnormalities in four patients with NKH and seizures. We prospectively evaluated clinical and radiological abnormalities in four patients with NKH during the period March 2004 to December 2005. All patients presented with seizures, either simple or complex partial seizures or epilepsia partialis continua. Two of them had transient hemianopia. MRI showed subcortical T2 hypointensity in the occipital white matter and in or around the central sulcus (two patients each), T2 hyperintensity of the overlying cortex (two patients), focal overlying cortical enhancement (three patients) and bilateral striatal hyperintensity (one patient). Diffusion-weighted imaging (DWI) performed in three patients showed restricted diffusion. The ictal semiology and electroencephalographic (EEG) findings correlated with the MRI abnormalities. On clinical recovery, the subcortical T2 hypointensity and striatal hyperintensity reversed in all patients. The initial cortical change evolved to FLAIR hyperintensity suggestive of focal cortical gliosis. The radiological differential diagnosis considered initially included encephalitis, malignancy and hemorrhagic infarct rendering a diagnostic dilemma. We identified subcortical T2 hypointensity rather than hyperintensity as a characteristic feature of seizures associated with NKH. Only very few similar reports exist in literature. Reversible bilateral striatal T2 hyperintensity in NKH has not been reported to the best of our knowledge. (orig.)

  2. Epilepsy in Latin America and the Caribbean: a survey on needs and resources Epilepsia en América Latina y el Caribe: encuesta sobre las necesidades y los recursos

    Directory of Open Access Journals (Sweden)

    Itzhak Levav

    1999-11-01

    iniciativa, denominada "Fuera de las sombras", en la que están trabajando la Liga Internacional contra la Epilepsia, la Oficina Internacional para la Epilepsia, la Organización Mundial de la Salud y la Organización Panamericana de la Salud con el fin de mejorar los servicios de atención a los pacientes epilépticos, la aceptación social de estos y el tratamiento de la enfermedad.

  3. Focal dermal hypoplasia without focal dermal hypoplasia

    NARCIS (Netherlands)

    Contreras-Capetillo, Silvina N.; Lombardi, Maria Paola; Pinto-Escalante, Doris; Hennekam, Raoul C.

    2014-01-01

    Focal dermal hypoplasia (FDH; Goltz-Gorlin syndrome) is an X-linked dominant disorder affecting mainly tissues of ectodermal and mesodermal origin. The phenotype is characterized by hypoplastic linear skin lesions, eye malformations, hair and teeth anomalies, and multiple limbs malformations. The

  4. The early history (1909-1961) of Epilepsia, the journal of the International League Against Epilepsy, and its echoes today.

    Science.gov (United States)

    Shorvon, Simon

    2007-01-01

    This paper records the history of Epilepsia, the journal of the International League Against Epilepsy, from its inception in 1908/1909 until the beginning of its fourth series in 1961. During this time, publication was interrupted on three occasions and so the journal appeared in four series, with a complex numbering system. Over the years, the content and format of the journal has varied. Its role has changed over the years, at times primarily as a scientific organ and at other times as a source of ILAE news and reports. Concerns throughout its history have included its role as an historical record, its international representation, financial vicissitude, quality of papers, the balance between basic and clinical science, the value of clinical papers, and issues of overspecialization. Epilepsia is today the leading clinical epilepsy journal; but these are still significant concerns, and a knowledge of the history of Epilepsia is important for understanding the current position of the journal.

  5. Factores de Riesgo para Recurrencia de Convulsiones y Pronóstico a Corto Plazo en Cirugía de Epilepsia para Esclerosis Mesial Temporal.

    Directory of Open Access Journals (Sweden)

    Héctor Jaramillo Betancur

    2009-07-01

    Full Text Available

    Objetivo: Determinar los factores de riesgo para recurrencia de convulsiones y la clasificación posquirúrgica a corto plazo en pacientes operados por esclerosis mesial temporal (EMT.

    Métodos: Estudio de casos y controles anidado en la cohorte de pacientes con EMT diagnosticados por resonancia magnética con dos años de seguimiento posquirúrgico; se excluyeron pacientes con EMT bilateral. Se evaluaron características clínicas prequirúrgicas, foco epileptogénico en video-EEG y variables quirúrgicas con respecto a recurrencia de convulsiones en los primeros dos años posquirúrgicos y clasificación de Engel en el primer y segundo aniversario de la cirugía.

    Resultados: Entre octubre de 2001 y junio de 2008 se han evaluado 144 pacientes con EMT candidatos a cirugía de epilepsia; a junio de 2007, se han operado 89 pacientes, 51.7% con EMT izquierda. 35.8% de los pacientes presentaron recurrencia de convulsiones antes del segundo año posquirúrgico; el factor de riesgo prequirúrgico asociado a recurrencia fue foco bitemporal o temporal único con diseminación contralateral por video-EEG (OR: 6.32; IC95% 1.64-26.41, y posquirúrgico, la presencia de convulsiones durante el primer mes posoperatorio (p:0.0004; no se encontró asociación con recurrencia para: género, convulsiones tónico-clónicas generalizadas prequirúrgicas, lado de la EMT ni tiempo de evolución prequirúrgica de la epilepsia. 66.3% y 75.8% de los pacientes estaban en Engel I al primer y segundo aniversario de la cirugía, respectivamente. 91% de los pacientes intervenidos estaban en buen pronóstico posquirúrgico a los dos años.

    Conclusión: La localización del foco epileptogénico por electrofisiología es factor determinante en el pronóstico posquirúrgico a corto plazo en EMT.

    Palabras clave

    Cirugía de epilepsia, convulsiones, epilepsia del lóbulo temporal

  6. Avaliação sistematica dos aspectos clinicos e geneticos de pacientes com epilepsias mioclonicas progressivas

    OpenAIRE

    Maria Isabel Caldeira Rodrigues Morais

    2003-01-01

    Resumo: As Epilepsias Mioclônicas Progressivas (EMPs), formam um grupo raro de desordens geneticamente determinadas e freqüentemente familiais. Caracterizam-se por apresentarem a tríade clínica: epilepsia, mioclonias e declínio neurológico progressivo, como demência e ataxia. As cinco principais causas desta síndrome são: doença de Unverricht-Lundborg (DUL), doença de Lafora (DL), as lipofuscinoses ceroides neuronais (LCN), as encefalomiopatias mitocondriais com fibras vermelhas rajadas (MERR...

  7. Alterações sexuais na epilepsia: resultados de uma avaliação multidisciplinar

    Directory of Open Access Journals (Sweden)

    ALMEIDA SILVA HELGA C.

    1999-01-01

    Full Text Available Onze pacientes do sexo masculino com epilepsia e queixa de alteração sexual foram submetidos a avaliação multidisciplinar. A média de idade foi 27 anos (20-34, a duração média da epilepsia foi 19 anos (0,5-32 e a frequência média das crises foi duas por semana (0-7. Dez pacientes apresentavam crises parciais e um, mioclônicas. Dez pacientes recebiam drogas antiepilépticas (difenil-hidantoína - 1, carbamazepina - 8, clonazepam - 3, clobazam - 2, valproato - 3, vigabatrina - 1. Segundo os critérios do DSM III -- R, as queixas foram disfunção erétil (9, redução da libido (4, froteurismo (4, inibição do orgasmo (3, ejaculação precoce (3, fetichismo (2, voyeurismo (2, exibicionismo (2, pedofilia (1 e aversão sexual (1. A avaliação endocrinológica mostrou hipogonadismo hipogonadotrófico em dois pacientes. A avaliação urológica revelou disfunção erétil orgânica em outros dois. Em um paciente a alteração sexual foi considerada psicogênica. Em seis pacientes não foi possível estabelecer diagnóstico etiológico definitivo. Este estudo mostra que a alteração da sexualidade na epilepsia é multifatorial e necessita de abordagem multidisciplinar.

  8. Projeto demonstrativo em epilepsia no Brasil National demonstration project on epilepsy in Brazil

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    Li Li Min

    2003-03-01

    Full Text Available A epilepsia é a condição neurológica grave de maior prevalência no mundo. Infelizmente, a maioria dos pacientes com epilepsia nos países em desenvolvimento não recebem tratamento adequado e sofrem estigmatização pelo diagnóstico. Diante deste cenário, em 1997 foi lançada uma Campanha Global Contra Epilepsia liderada pela Organização Mundial da Saúde, a Internacional League Against Epilepsy, e International Bureau for Epilepsy. A Campanha entrou na sua segunda fase em 2001 com os projetos demonstrativos que estão em curso na China, Zimbábue, Senegal e recentemente no Brasil. A finalidade do projeto demonstrativo é mostrar através de avaliação metodológica que é possível estabelecer um modelo de atendimento integral aos pacientes com epilepsia. O projeto demonstrativo brasileiro tem como regiões de atuação Campinas e São José de Rio Preto. Uma Task Force foi instituída para estudar a expansão da atuação para outras áreas do país.Epilepsy is the most prevalent non-communicable serious neurological condition worldwide. Unfortunately, the majority of people with epilepsy in low-income countries do not receive appropriate treatment. Stigmatisation is the rule. In this setting, the World Health Organisation, the International League against Epilepsy and the International Bureau for Epilepsy launched the Global Campaign against Epilepsy in 1997. This entered its second phase in 2001 and as part of it has set up demonstration projects in the People's Republic of China, Zimbabwe, Senegal and, more recently, in Brazil. The objective of the demonstration projects is to show, through methodological evaluation, that it is possible to establish a model of treatment for people with epilepsy in primary health care settings. The Brazilian demonstration project has targeted regions in Campinas and São Jose do Rio Preto, both in Sao Paulo State. A task force has been established to assess strategies to expand this project

  9. "Lapsellamme on epilepsia - ohjaisitko meitä?" : cd-rom ohjausmateriaali sairaanhoitajille

    OpenAIRE

    Siitari, Hanna; Tupamäki, Enni

    2007-01-01

    Epilepsia on yksi lasten yleisimmistä pitkäaikaissairauksista. Sairauden yleisyydestä huolimatta siihen liittyy edelleen paljon vääriä mielikuvia. Todellisuudessa epilepsiaan ei liity mitään hämäräperäistä ja nykyisillä hoitomenetelmillä suurin osa tautia sairastavista saavuttaa kohtauksettomuuden. Taudin hyvästä ennusteesta huolimatta perhe tarvitsee paljon tukea ja ohjausta hoitohenkilökunnalta lapsen sairastuttua pitkäaikaissairauteen. Opinnäytetyön tavoitteena oli tuottaa Keski-Suomen kes...

  10. Comparision between biphasic helical CT and dynamic gadolinium-enhanced MR in the detection and characterization of focal hepatic lesions in cirrhotic patients; Estudio comparativo entre TC helicoidal bifasica y RM dinamica con gadolinio en la deteccion y caracterizacion de lesiones focales hepticas en pacientes cirrticos

    Energy Technology Data Exchange (ETDEWEB)

    Puig, J; Martn, J; Donoso, L; Falco, J; Rue, M [Consorcio Hospitalario del Parc Taul. Sabadell. Barcelona (Spain)

    1998-12-31

    To assess the agreement between biphasic helical computerized tomography (BHCT) and dynamic gadolinium-enhanced magnetic resonance (MR) in the detection and characterization of focal hepatic lesions in a group of cirrhotic patients. A prospective study was done in 50 cirrhotic patients suspected of having hepatocarcinoma (HC) on the basis of ultrasonographic images evaluated by means of BHCT and dynamic gadolinium-enhanced MR using fast low-angle shot (FLASH) sequences (110-135/4/90 degree centigree). The images were assessed jointly by four radiologists. Between the two techniques, a total of 83 lesions were detected. MR disclosed more lesions (n=79) than BHCT (n=67) (p<0.005). Moreover, 25 of the lesions that were visible by both techniques were more clearly evident in MR images (p<0.01). MR correctly classified 6 of 7 benign lesions (85%) and 49 of 66 malignant ones (74%). BHCT correctly classifed 2 of 7 benign lesions (28%) and 32 of 66 malignant ones (48%). The sensitivities of MR and BHCT for the characterization of these lesions were 74% and 48%, respectively (p=0.0009), while the respective specificities were 86% and 29% (P<0.001). Dynamic gadolinium-enhanced MR with FLASH sequences is more efficient than BHCT in the detection and characterization of focal lesions in cirrhotic patients. (Author) 37 refs.

  11. Notes on the origins of Epilepsia and the International League Against Epilepsy.

    Science.gov (United States)

    Shorvon, Simon D; Weiss, Giselle; Goodkin, Howard P

    2009-03-01

    The recent discovery of archival material has shed interesting light on the origins of Epilepsia and also the International League Against Epilepsy (ILAE). The idea of an international journal devoted to epilepsy seems first to have arisen from talks between Dr. L. J. J. Muskens and Dr. W. Aldren Turner in 1905. A protracted series of subsequent letters between Muskens and a Haarlem publisher show how the idea slowly took shape. The committee of patronage, editorial board, and editorial assistants was probably first approached at the First International Congress of Psychiatry, Neurology, Psychology, and Nursing of the Insane, held in Amsterdam in 1907. At this meeting, the concept of an international organization to fight epilepsy (to become the ILAE) was also first proposed in public, again by Muskens. The concept of the ILAE was clearly modeled on another international organization-the International Commission for the Study of the Causes of Mental Diseases and Their Prophylaxis. This Commission had been first publicly proposed in 1906 by Ludwig Frank, at the Second International Congress for the Care and Treatment of the Insane. The proposed Commission and ILAE shared many features, aims, and personnel. Despite an auspicious start, the International Commission was prevented by personal and political differences from ever actually coming into being. However, the first issue of Epilepsia appeared in March 1909 and the ILAE was inaugurated in August 1909; and both have flourished and celebrate their centenaries this year.

  12. Focal retinal phlebitis.

    Science.gov (United States)

    Hoang, Quan V; Freund, K Bailey; Klancnik, James M; Sorenson, John A; Cunningham, Emmett T; Yannuzzi, Lawrence A

    2012-01-01

    To report three cases of solitary, focal retinal phlebitis. An observational case series. Three eyes in three patients were noted to have unilateral decreased vision, macular edema, and a focal retinal phlebitis, which was not at an arteriovenous crossing. All three patients developed a branch retinal vein occlusion at the site of inflammation. These patients had no other evidence of intraocular inflammation, including vitritis, retinitis, retinal vasculitis, or choroiditis, nor was there any systemic disorder associated with inflammation, infection, or coagulation identified. Focal retinal phlebitis appears to be an uncommon and unique entity that produces macular edema and ultimately branch retinal vein occlusion. In our patients, the focal phlebitis and venous occlusion did not occur at an arteriovenous crossing, which is the typical site for branch retinal venous occlusive disease. This suggests that our cases represent a distinct clinical entity, which starts with a focal abnormality in the wall of a retinal venule, resulting in surrounding exudation and, ultimately, ends with branch retinal vein occlusion.

  13. Recurrent Bilateral Focal Myositis.

    Science.gov (United States)

    Nagafuchi, Hiroko; Nakano, Hiromasa; Ooka, Seido; Takakuwa, Yukiko; Yamada, Hidehiro; Tadokoro, Mamoru; Shimojo, Sadatomo; Ozaki, Shoichi

    This report describes a rare case of recurrent bilateral focal myositis and its successful treatment via methotrexate. A 38-year-old man presented myalgia of the right gastrocnemius in May 2005. Magnetic resonance imaging showed very high signal intensity in the right gastrocnemius on short-tau inversion recovery images. A muscle biopsy revealed inflammatory CD4+ cell-dominant myogenic change. Focal myositis was diagnosed. The first steroid treatment was effective. Tapering of prednisolone, however, repeatedly induced myositis relapse, which progressed to multiple muscle lesions of both lower limbs. Initiation of methotrexate finally allowed successful tapering of prednisolone, with no relapse in the past 4 years.

  14. Experimental Focal Cerebral Ischemia

    DEFF Research Database (Denmark)

    Christensen, Thomas

    2007-01-01

    Focal cerebral ischemia due to occlusion of a major cerebral artery is the cause of ischemic stroke which is a major reason of mortality, morbidity and disability in the populations of the developed countries. In the seven studies summarized in the thesis focal ischemia in rats induced by occlusion...... in the penumbra is recruited in the infarction process leading to a progressive growth of the infarct. The penumbra hence constitutes an important target for pharmacological treatment because of the existence of a therapeutic time window during which treatment with neuroprotective compounds may prevent...

  15. Epilepsia e arte: relação, interação ou conseqüência = Epilepsy and art: relation, interaction or consequence

    Directory of Open Access Journals (Sweden)

    Garcia, Pedro Celiny Ramos

    2005-01-01

    Full Text Available Objetivo: Este artigo tem como objetivo revisar estudos envolvendo epilepsia e arte, mostrando o sofrimento, alegria, criações e adversidades destes com a epilepsia. Método: Revisão bibliográfica (Medline, Lilacs, selecionando aspectos sobre epilepsia e arte. Conclusão: O texto discorre sobre a vida e obras de grandes nomes da arte que tiveram suas vidas marcadas e influenciadas pela epilepsia; e suas manifestações sociais, psíquicas e físicas Objective: This article aims to revise studies involving epilepsy and art, showing the suffering, joy, creations and adversities of these artists with epilepsy. Methods: A revision of bibliography (Medline and Lilacs was done , selecting aspects on epilepsy and art. Conclusions: This article is about the life and works of great names in art who had their lives marked by epilepsy and it’s social, psychological and physical manifestations.

  16. TRASTORNOS DE LA ATENCION Y HALLAZGOS ELECTROENCEFALOGRAFICOS EN NIÑOS CON CRISIS PARCIALES COMPLEJAS

    OpenAIRE

    Aguilar-Fabré, Liane; Rodríguez-Valdés, René

    2008-01-01

    Los problemas atencionales tienen una alta prevalencia en los niños con epilepsia existiendo muchas interrogantes acerca de su fisiopatología. Caracterizar la atención en un grupo de niños epilépticos. Se estudiaron 12 niños con crisis parciales complejas y se les realizó electroencefalograma y una batería neuropsicológica evaluadora de la atención sostenida, dividida y selectiva. Se realizo un ANOVA no paramétrico U Mann Whitney para conocer la existencia de diferencias significativas entre ...

  17. Causas de epilepsia tardia em uma clínica de epilepsia do Estado de Santa Catarina Etiologies of late-onset epilepsy in an epilepsy clinic of Santa Catarina - Southern Brazil

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    MARCELO RIGATTI

    1999-09-01

    Full Text Available OBJETIVO: Identificar em nossa sociedade as etiologias mais prováveis de epilepsia iniciada após os 18 anos de idade. MÉTODO: Estudo retrospectivo e descritivo na CME/SUS de Florianópolis de 1990 à 1998, analisando 120 prontuários de pacientes com epilepsia tardia, isto é, aqueles que iniciaram suas crises epilépticas dos 18 anos em diante. As variáveis coletadas foram: idade da primeira crise, etiologias prováveis, história mórbida familiar. RESULTADOS: A prevalência encontrada para epilepsia tardia foi 29,48%.Epilepsias parciais sintomáticas foram majoritárias e as etiologias mais frequentes e relevantes encontradas foram: cisticercose com cerca de 20%, trauma crânio encefálico com 15%, convulsão febril na infância com 5% e 35% da amostra foi classificada como idiopática. CONCLUSÃO: prevalência de epilepsia de início tardio em nossa sociedade é 29,48%, cifra ligeiramente superior à relatada em países desenvolvidos (25%. Muito provavelmente, esta diferença é consequência do caráter epidêmico de cisticercose entre nós. Além disso, trauma crânio encefálico e crises febris são etiologias comuns. Profilaxia de epilepsia é viável e urgentemente necessária em nosso Estado.OBJECTIVE: To identify the most common etiologies of late-onset epilepsy in our society. METHOD: Retrospective and descriptive study in the CME/SUS of Florianópolis from 1990 to 1998, evaluating 120 handbooks of patients with late-onset epilepsy, that is, those that had initiated epileptic seizures of the 18 years in ahead. The collected variables were: age of the first seizure, etiologies and morbid familial history. RESULTS: The prevalence rate found for late-onset epilepsy was 29.48%. Most of the sample had partial symptomatic epilepsy and the most frequent and important were: cysticercosis with 20%, head trauma with 15%, febrile convulsions in infancy with 5% and 35% were classified as idiopatic. CONCLUSION: Prevalence of late

  18. Dieta cetogénica como tratamiento de la epilepsia refractaria

    OpenAIRE

    Barrena Barbadillo, Rocío

    2016-01-01

    Trabajo final de máster en el que se analiza la efectividad de la dieta cetogénica como tratamiento para la epilepsia refractaria a fármacos. Análisis de las diferentes dietas cetogénicas existentes, mecanismo de acción, efectividad, indicaciones, contraindicaciones efectos adversos e implementación de la dieta. Treball final de màster en el qual s'analitza l'efectivitat de la dieta cetogènica com a tractament per l'epilèpsia refractària a fàrmacs. Anàlisi de les diferents dietes cetogèniq...

  19. Epilepsia temporal estudo psiquiátrico evolutivo de uma série tratada cirurgicamente

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    Cláudio Rossi

    1988-03-01

    Full Text Available Os autores estudaram do ponto de vista psiquiátrico, no pré e no pós-operatório, série de 31 casos operados por epilepsia temporal incontrolável. Esta, com seu substrato fisiopatológico, está associada a irritabilidade patológica, tenacidade afetiva, impulsividade, disfunção cognitiva epiléptica e deficiências de abstração nos processos intelectuais. As altas incidências dessas psicopatologias nos doentes estudados demonstram essa associação e sugerem fortemente a existência de relação causal entre elas e a epilepsia temporal. As lobectomias temporais unilaterais se mostraram eficazes para o controle das crises epilépticas, cuja freqüência se reduziu intensamente no pós-operatório. As cirurgias promoveram intensa e útil redução nas manifestações da irritabilidade patológica, da impulsividade, da disfunção cognitiva epiléptica e das instabilidades da capacidade de abstração promovidas por impactos afetivos. A tenacidade afetiva foi pouco alterada pelas operações, embora tenha ocorrido efeito favorável. Incapacidades de abstração, estáveis, não foram afetadas pelas cirurgias. A presença de focos em ambos os lobos temporais não diminuiu a eficácia da cirurgia, nem quanto a seu efeito sobre as crises, nem quanto a seu efeito sobre as alterações psicopatológicas estudadas.

  20. Focal myositis: A review.

    Science.gov (United States)

    Devic, P; Gallay, L; Streichenberger, N; Petiot, P

    2016-11-01

    Amongst the heterogeneous group of inflammatory myopathies, focal myositis stands as a rare and benign dysimmune disease. Although it can be associated with root and/or nerve lesions, traumatic muscle lesions and autoimmune diseases, its triggering factors remain poorly understood. Defined as an isolated inflammatory pseudotumour usually restricted to one skeletal muscle, clinical presentation of focal myositis is that of a rapidly growing solitary mass within a single muscle, usually in the lower limbs. Electromyography shows spontaneous activity associated with a myopathic pattern. MRI reveals a contrast enhanced enlarged muscle appearing hyper-intense on FAT-SAT T2 weighted images. Adjacent structures are spared and there are no calcifications. Serum creatine kinase (CK) levels are usually moderately augmented and biological markers of systemic inflammation are absent in most cases. Pathological histological features include marked variation in fibre size, inflammatory infiltrates mostly composed of T CD4+ lymphocytes and macrophages, degenerating/regenerating fibres and interstitial fibrosis. Differential diagnoses are numerous and include myositis of other origin with focal onset. Steroid treatment should be reserved for patients who present with major pain, nerve lesions, associated autoimmune disease, or elevated C reactive protein or CK. Copyright © 2016 Elsevier B.V. All rights reserved.

  1. Algunas consideraciones en relación con los medicamentos antiepilépticos de nueva generación en los niños Some considerations in relation to the new generation antiepileptic drugs in children

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    Desiderio Pozo Lauzán

    2005-06-01

    Full Text Available El objetivo de este trabajo es revisar las principales drogas antiepilépticas de segunda generación y su administración en los niños: vigabatrina, felbamato, lamotrigina, topiramato, tiagabina, oxcarbazepina, zonisamida, levetiracetam y stiripentol. Al inicio se recomendaron en pacientes adultos con epilepsias focales refractarias, sin embargo desde hace varios años, se ha demostrado su eficacia en diferentes tipos de crisis en los niños. La lamotrigina y el topiramato se consideran medicamentos de amplio espectro. Se enfatiza en el metabolismo, vías de eliminación, indicaciones, dosis en los niños, interacciones medicamentosas y efectos colaterales de los medicamentos antiepilépticos de segunda generación. Se mencionan algunos de los nuevos medicamentos que actualmente están en investigación como antiepilépticos y que constituyen una tercera generaciónThe objective of this paper is to review the main second generation antiepileptic drugs and their administration in children: vigatrine, felbamate, lamotrigine, topiramate, tiagabine, oxcarbazepine, zonisamide, leventiracetam and stiripentol. At the beginning, they were recommended in adult patients with focal refractory epilepsies; however, their efficacy in different types of seizures in children has been proved for some years. Lamotrigine and topiramate are considered drugs of wide spectrum. Emphasis is made on metabolism, routes of elimination, indications, doses in children, drug interactions and side effects of the second generation antiepileptic drugs. Some of the new drugs that are currently under study as antiepileptic and that constitute a third generation, are mentioned.

  2. Protocolos de investigação de variáveis psicológicas na epilepsia infantil

    Directory of Open Access Journals (Sweden)

    Paula Teixeira Fernandes

    Full Text Available A epilepsia é uma condição crônica comum na infância, cujo diagnóstico mostra dificuldades psicossociais e de ajustamento familiar, que parecem estar relacionadas com crenças e qualidade da interação pais-filhos. Este trabalho teve como objetivo esquematizar estratégias de investigação para as variáveis familiares e psicológicas: crenças, impacto da doença, relacionamento familiar, identificação de mudanças. A partir do levantamento de relatos dos pais de crianças com epilepsia e de aspectos da literatura, foram elaborados questionários psicológicos para identificar as importantes variáveis que afetam a vida da criança com epilepsia e sua família. Diante deste contexto, pode-se concluir que o uso de protocolos de investigação mais adequados facilita a avaliação psicológica e garante a coleta de dados.

  3. Demonstration project on epilepsy in Brazil: situation assessment Projeto demonstrativo em epilepsia no Brasil: avaliação situacional

    Directory of Open Access Journals (Sweden)

    Li M. Li

    2007-06-01

    educational program should be broad spectrum and include not only medical management, but also psycho-social aspects of epilepsy.OBJETIVO: Avaliar a situação da assistência à epilepsia no contexto da atenção primária sob o Projeto Demonstrativo em epilepsia no Brasil, parte da Campanha Global Epilepsia Fora das Sombras da WHO/ILAE/IBE. MÉTODO: Fizemos um levantamento epidemiológico para definir a prevalência e lacuna de tratamento em epilepsia. Avaliamos a percepção de 598 profissionais de saúde da atenção básica de diferentes regiões do Brasil sobre epilepsia e seu manejo na rede básica de saúde. RESULTADOS: A prevalência acumulada de epilepsia foi de 9,2/1000 pessoas (95%IC= 8,4-10 e a prevalência estimada de epilepsia ativa foi de 5,4/1000 pessoas. Trinta e oito porcento dos pacientes com epilepsia ativa estavam sendo tratados inadequadamente, incluindo 19% que estavam sem medicação. A enquete com os profissionais de saúde mostrou que a média estimada de pacientes livre de crises sob os cuidados dos mesmos era de 60%. A média estimada de porcentagem em monoterapia era de 55%. A média estimada de porcentagem de referência para neurologistas era de 59%. A média estimada de porcentagem de pacientes que estavam trabalhando ou estudando era de 56%. A maioria dos médicos não se sente confiante em atender uma pessoa com epilepsia. DISCUSSÃO: A análise situacional da Fase I - estudo epidemiológico nas áreas de interesse do PD mostrou que a prevalência da epilepsia é similar a outros países em desenvolvimento e a lacuna de tratamento é grande. Um dos fatores importantes para a lacuna de tratamento é a falta de adequação à assistência na atenção básica. Essa situação pode ser revertida no Brasil, pois os elementos chaves existem na rede básica para o manejo de pessoas com epilepsia. Entretanto, para torna efetivo e eficiente é preciso i estabelecimento de um sistema de referência e contra-referência, ii fornecimento contínuo de

  4. El recién nacido febril sin signos de focalización y con punción lumbar fallida en la evaluación inicial The febrile newborn infant with signs of focalization and with failed lumbar puncture in the initial evaluation

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    Manuel Díaz Álvarez

    2008-03-01

    Full Text Available INTRODUCCIÓN. La punción lumbar está indicada en la evaluación inicial del recién nacido febril sin signos de focalización. Sin embargo, esta puede resultar fallida y crear incertidumbre en el manejo del tratamiento antibiótico. Fue objetivo de este trabajo verificar el tratamiento y evolución de los recién nacidos febriles sin signos de focalización, cuando la punción lumbar resultó fallida en la evaluación inicial. MÉTODOS. Se estudiaron retrospectivamente 150 recién nacidos febriles sin signos de focalización y con punción lumbar fallida en la evaluación inicial, ingresados en el servicio de neonatología de nuestro hospital entre 1992 y el 2000. Todos los pacientes se clasificaron según criterios de bajo riesgo de infección bacteriana grave. El uso de tratamiento antibiótico estuvo sujeto a la consideración del médico que hizo la evaluación inicial. Se calcularon índice y tasa de punción lumbar fallida, se midió la relación entre la indicación de tratamiento antibiótico inicialmente y la clasificación de riesgo de infección bacteriana grave, y verificamos la evolución de los pacientes. RESULTADOS. Fueron fallidas 150 de 1174 punciones lumbares (8,5 % para un índice de 9,2. Los recién nacidos calificados de alto riesgo recibieron con mayor frecuencia tratamiento antibiótico (23,3 % en contraste con los catalogados de bajo riesgo, quienes fueron tratados predominantemente sin antibióticos (36,0 % (p = 0,03. Egresaron vivos 149 neonatos (99,3 %, tanto con uso de antibióticos como sin él. Sin embargo, hubo un fallecido clasificado de alto riesgo de infección bacteriana grave que recibió tratamiento antibiótico desde el inicio. CONCLUSIONES. La punción lumbar puede resultar fallida al evaluar a recién nacidos febriles sin signos de focalización. La indicación de tratamiento antimicrobiano en estos pacientes estuvo relacionada significativamente con la clasificación de riesgo de infección bacteriana

  5. Paradigms for subdural grids' implantation in patients with refractory epilepsy Paradigmas para implante de placas subdurais em pacientes com epilepsia refratária

    Directory of Open Access Journals (Sweden)

    ARTHUR CUKIERT

    2000-09-01

    , SPECT e RM diminuíram em muito a necessidade da utilização de eletrodos invasivos na investigação pré-operatória de pacientes epilépticos. No entanto, 10 a 30% dos pacientes com epilepsias refratárias ainda possuem investigação não-invasiva inconclusiva. Este estudo relata nossos paradigmas para o implante de eletrodos subdurais nesta população de epilépticos refratários. MÉTODOS: Vinte e nove pacientes portadores de epilepsias refratárias foram estudados. Eles foram divididos em 5 grupos de síndromes epilépticas que incluíam a maioria dos pacientes submetidos a implantes: bitemporais (grupo I; n=16, bifrontomesiais (grupo II; n=5, hemisféricos (grupo III; n=2, quadrante anterior (grupo IV; n=3 e quadrante posterior (grupo V; n=3. Todos foram submetidos a extensos implantes subdurais (de 64 a 160 contatos cobrindo todo o córtex potencialmente epileptogênico, sob anestesia geral. RESULTADOS: Todos pacientes toleraram bem o procedimento. Vinte e dois pacientes referiram cefaléia. Não houve outro sinal ou sintoma sugestivo de hipertensão intracraniana. Com exceção de um paciente do grupo II, a monitorização eletrocorticográfica crônica foi capaz de definir uma área focal própria para a ressecção cortical. A estimulação cortical foi capaz de mapear as áreas eloquentes necessárias em todos os pacientes dos grupos II a V. CONCLUSÃO: Alguns pacientes com epilepsia refratária ainda necessitam de avaliação invasiva apesar dos avanços nos métodos diagnósticos pré-operatórios. A padronização dos paradigmas para implante subdural destes pacientes bem como o estudo de populações homogêneas de pacientes definidas por RM levará a melhor compreensão da fisiopatologia envolvida nestes casos bem como a melhores resultados cirúrgicos.

  6. Stigma scale of epilepsy: validation process Escala de estigma na epilepsia: processo de validação

    Directory of Open Access Journals (Sweden)

    Paula T. Fernandes

    2007-06-01

    Full Text Available PURPOSE: To validate a Stigma Scale of Epilepsy (SSE. METHODS: The SSE was completed by 40 adult with epilepsy attending an Outpatient Epilepsy Clinic at the University Hospital of UNICAMP, and by 40 people from the community. People were interviewed on an individual basis; a psychologist read the questions to the subjects who wrote the answers in a sheet. The procedure was the same for all the subjects and completion took around ten minutes. RESULTS: The SSE has 24 items. The internal consistency of the SSE showed alpha Cronbach’s coefficient 0.88 for the patients with epilepsy and 0.81 for the community. The overall mean scores of the Stigma Scale of Epilepsy formula were: 46 (SD=18.22 for patients and 49 (SD=13.25 for the community where a score of 0 would suggest no stigma, and 100 maximum stigma. DISCUSSION: The SSE has satisfactory content validity and high internal consistency. It allows the quantification of the perception of stigma by patients and people from community; this can then be used for interventional studies, such as mass media campaign in minimizing the negative facets of stigma.OBJETIVO: Validar a Escala de Estigma na Epilepsia (EEE. MÉTODO: A EEE foi aplicada em 40 pacientes adultos com o diagnóstico de Epilepsia do Ambulatório de Epilepsia do HC/Unicamp e em 40 pessoas da comunidade em geral. Os sujeitos foram entrevistados individualmente pelas psicólogas, que foram lendo as questões e anotando as respostas na escala. As condições de aplicação foram as mesmas e a aplicação durou cerca de 10 minutos. RESULTADOS: A EEE possui 24 itens. A consistência interna da EEE mostrou alfa de Cronbach, de 0,88 para os pacientes com epilepsia e 0,81 para a comunidade. As médias do valor geral de estigma obtido com a fórmula da EEE foram: 46 (DP=18,22 para os pacientes e 49 (DP=13,25 para a comunidade. DISCUSSÃO: A EEE possui uma satisfatória validade e alta consistência interna. Isso permite uma quantificação da

  7. Nutrición del Niño con Enfermedades Neurológicas Prevalentes: An Update

    OpenAIRE

    LE ROY O, CATALINA; REBOLLO G, MARÍA JESÚS; MORAGA M, FRANCISCO; DÍAZ SM, XIMENA; CASTILLO-DURÁN, CARLOS

    2010-01-01

    En este artículo se revisan algunas enfermedades neurológicas en donde el manejo nutricional tiene un rol relevante, como son la parálisis cerebral, epilepsia, autismo y síndrome de déficit atencional (SDAH). La nutrición frecuentemente es afectada en niños con parálisis cerebral por factores como la enfermedad de base, la dificultad en ingerir alimentos por alteraciones sensoriales, motoras y/o gastrointestinales y las deficiencias nutricionales específicas relacionadas con la ingesta insufi...

  8. Tratamento de epilepsia: consenso dos especialistas brasileiros Treatment of epilepsy: consensus of the Brazilian specialists

    Directory of Open Access Journals (Sweden)

    Luiz Eduardo Betting

    2003-12-01

    Full Text Available Epilepsia é uma condição muito freqüente em todo o mundo. Na última década, várias opções terapêuticas surgiram ou foram aprimoradas. O principal método utilizado para decisão terapêutica baseia-se nos estudos randomizados, que representam o maior nível de evidência. Entretanto, mesmo estes estudos são passíveis de críticas e em alguns casos o tratamento de escolha permanece controverso. Nestas situações, a opinião dos especialistas, na área da epileptologia, com maior experiência clínica, passa a ter grande valor. O presente estudo tem como principal objetivo elaborar um consenso de tratamento das epilepsias, através da opinião de experts brasileiros no assunto. Este consenso poderá auxiliar na criação de manuais e estratégias para o tratamento de determinadas síndromes epilépticas, de acordo com os padrões socioeconômicos brasileiros.Epilepsy is a frequent condition in the world. Recently a study in Brazil showed prevalence of 18/1000 inhabitants in São José do Rio Preto, São Paulo State. In the last decade, new therapeutic options were discovered or developed. The main therapeutic decision method is based on randomized clinical trials. This method represents the higher level of evidence. However, even these studies have limitations and in some cases the treatment of choice remains controversial. In these instances, the epilepsy experts' opinions become helpful. In 2001 a similar study had been conducted in USA. The aim of this study is to create guidelines for epilepsy treatment based on the opinion of the Brazilian experts. These guidelines can be used to create manuals and strategies for the treatment of some epileptic syndromes according to Brazilian experts. As compared to the North-American guidelines our study better reflects the resources available in our country.

  9. Efeito antioxidante da buspirona no modelo de epilepsia induzida por pilocarpina

    Directory of Open Access Journals (Sweden)

    Paula Benvindo Ferreira

    2012-01-01

    Full Text Available CONTEXTO: Crises epilépticas induzidas por pilocarpina podem produzir alterações histopatológicas em muitas regiões cerebrais como consequência da produção excessiva de radicais livres. OBJETIVO: O objetivo do presente estudo foi avaliar o efeito antioxidante da buspirona no modelo de epilepsia induzida por pilocarpina. MATERIAL E MÉTODOS: Quarenta e oito animais foram divididos em quatro grupos. O primeiro grupo foi tratado com solução salina 0,9% (Controle. O segundo grupo foi tratado com pilocarpina 400 mg/kg (P400. Por sua vez, o terceiro grupo foi tratado com buspirona 5 mg/kg (BUSP durante 14 dias consecutivos. Já os animais do quarto grupo foram tratados com buspirona durante 14 dias consecutivos, e, 30 minutos após a última administração dela, os camundongos receberam P400 (BUSP + P400. RESULTADOS: Durante o período do tratamento não se observaram sinais de toxicidade e nenhuma morte entre os animais tratados com buspirona. Em nosso estudo o grupo tratado com P400 demonstrou um aumento significativo da produção de nitrito e nos níveis de peroxidação lipídica após as crises epilépticas. Por outro lado, no hipocampo dos animais que receberam o pré-tratamento com buspirona e após 30 minutos receberam P400, foi observada redução significativa nos níveis de peroxidação lipídica (65% e nitrito (85%, bem como aumento na atividade da enzima superóxido dismutase. CONCLUSÃO: O pré-tratamento com BUSP aumentou a latência para primeira crise epiléptica e diminuiu a taxa de mortalidade e o número de animais que apresentaram crise epiléptica e que progridem para o estado de mal epiléptico. Além disso, apresentou efeitos anticonvulsivantes associados com a redução do estresse oxidativo hipocampal no modelo de epilepsia induzida por pilocarpina.

  10. Focal femoral condyle resurfacing.

    LENUS (Irish Health Repository)

    Brennan, S A

    2013-03-01

    Focal femoral inlay resurfacing has been developed for the treatment of full-thickness chondral defects of the knee. This technique involves implanting a defect-sized metallic or ceramic cap that is anchored to the subchondral bone through a screw or pin. The use of these experimental caps has been advocated in middle-aged patients who have failed non-operative methods or biological repair techniques and are deemed unsuitable for conventional arthroplasty because of their age. This paper outlines the implant design, surgical technique and biomechanical principles underlying their use. Outcomes following implantation in both animal and human studies are also reviewed. Cite this article: Bone Joint J 2013;95-B:301-4.

  11. Systemic focal epileptogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Remler, M.P.; Marcussen, W.H.

    1986-01-01

    Rats that receive radiation to 0.25 cc of one cerebral hemisphere are clinically and electroencephalographically normal until there is a breakdown of the blood-brain barrier (BBB) at 3 to 6 months postradiation. This BBB lesion can be detected by transient focal seizure activity produced by the BBB-excluded systemic convulsant bicuculline methiodide. In two rats the seizure activity induced by this one injection was self-sustaining. In seven of 15 other rats tested, the subsequent administration of repeated 2 mg/kg injections created a chronic focus that continued to spike with great frequency for 3 weeks or more without further administration of any convulsant. In three of eight other rats, implanted minipumps delivering 180 micrograms/h of bicuculline methiodide produced self-sustaining epileptic activity.

  12. Epilepsia de lobo temporal com atrofia hipocampal: funções neuropsicológicas, qualidade de vida e adequação social

    OpenAIRE

    Juliana de Oliveira Gois

    2010-01-01

    A presença de déficits cognitivos nos indivíduos com epilepsia de lobo temporal é amplamente reconhecida, sendo os mesmos caracterizados por prejuízos da capacidade de nomeação, memória e função executiva. Embora as disfunções mnésticas sejam bastante estudadas na epilepsia de lobo temporal, a presença de disfunção executiva permanece controversa. A epilepsia gera, ainda, restrições na vida diária e prejuízo na qualidade de vida, levando a alterações na vida do indivíduo, tanto no aspecto fís...

  13. Topiramato: uma experiência em crianças com epilepsia parcial

    Directory of Open Access Journals (Sweden)

    Rocha Cristiane

    2001-01-01

    Full Text Available Estudamos a resposta clínica ao topiramato (TPM em crianças abaixo de 15 anos de idade. O tratamento foi iniciado com doses de 12,5 mg/kg/dia (1-7 mg/kg/dia, com aumentos semanais de 12,5 mg. Foram estudadadas 11 crianças, 9 do sexo feminino e 2 do masculino, de 3 a 14 anos de idade, com epilepsia parcial associada a etiologias diversas. Apenas um paciente teve dor abdominal intensa. Após o início do TPM, um paciente teve controle total das crises, 5 tiveram melhora maior que 75% na frequência delas, 1 paciente apresentou melhora em 50% e 3 não tiveram controle. Ao final, verificamos controle adequado das crises mesmo em quadros mais graves, com doses de até 100 mg/dia do TPM e em associação a carbamazepina, na maioria dos casos.

  14. Steroid-Responsive Epilepsia Partialis Continua with Anti-Thyroid Antibodies: A Spectrum of Hashimoto's Encephalopathy

    Directory of Open Access Journals (Sweden)

    Hiroki Masuda

    2014-05-01

    Full Text Available Background: When a neuropsychiatric symptom due to encephalopathy develops in a patient with anti-thyroid antibodies, especially when the symptom is steroid-responsive, Hashimoto's encephalopathy (HE needs to be included in the differential diagnosis of the patient. Although HE is an elusive disease, it is thought to cause various clinical presentations including seizures, myoclonus, and epilepsia partialis continua (EPC. Case Report: We present the case of a 33-year-old Japanese woman who acutely developed EPC in the right hand as an isolated manifestation. A thyroid ultrasound showed an enlarged hypoechogenic gland, and a thyroid status assessment showed euthyroid with high titers of thyroid antibodies. A brain MRI revealed a nodular lesion in the left precentral gyrus. Corticosteroid treatment resulted in a cessation of the symptom. Conclusions: A precentral nodular lesion can be responsible for steroid-responsive EPC in a patient with anti-thyroid antibodies and may be caused by HE. The serial MRI findings of our case suggest the presence of primary demyelination, with ischemia possibly due to vasculitis around the demyelinating lesion.

  15. Awareness, attitudes and perceptions on epilepsy in Southern Brazil Conhecimento, atitudes e percepções sobre epilepsia no Sul do Brasil

    Directory of Open Access Journals (Sweden)

    Asdrubal Falavigna

    2007-12-01

    Full Text Available OBJECTIVE: To verify awareness and attitudes toward epilepsy in Southern Brazil. METHOD: A questionnaire about familiarity with the disease, awareness and attitudes toward epileptics was applied to 832 inhabitants of Caxias do Sul. The answers were analyzed in three different groups: G1, non-university students; G2, university students up to the second year; and G3, university students with more than two years education and university graduates. RESULTS: University students and graduates are better informed regarding causes and treatment of epilepsy. Moreover, those interviewees present less negative attitudes toward epileptics. However, a large part of that group lacks some basic information on the disease. CONCLUSION: There is lack of information on epilepsy among Brazilians. Education campaigns should be carried out in order to clarify some aspects concerning epilepsy.OBJETIVO: Verificar o conhecimento e as atitudes sobre epilepsia na população de Caxias do Sul. MÉTODO: Foi aplicado um questionário sobre familiaridade com a doença, conhecimentos e atitudes diante de um portador de epilepsia a 832 moradores da cidade. As respostas foram analisadas em três grupos distintos: G1, não-universitários; G2, universitários até o segundo ano; e G3, universitários com mais de dois anos e graduados. RESULTADOS: Os universitários e graduados possuem melhor conhecimento sobre causas e tratamento da epilepsia. Além disso, esses entrevistados apresentam menos atitudes negativas para com o portador de epilepsia. Entretanto, uma boa parte desse grupo apresenta falta de alguns conhecimentos básicos sobre a doença. CONCLUSÃO: Há falta de informação à população brasileira sobre epilepsia. Campanhas educacionais devem ser realizadas no intuito de desmistificar alguns aspectos concernentes à epilepsia.

  16. Focal midbrain tumors in children

    NARCIS (Netherlands)

    Vandertop, W. P.; Hoffman, H. J.; Drake, J. M.; Humphreys, R. P.; Rutka, J. T.; Amstrong, D. C.; Becker, L. E.

    1992-01-01

    The clinical and neuroradiological features of focal midbrain tumors in 12 children are described, and the results of their surgical management are presented. Patients with a focal midbrain tumor usually exhibit either symptoms and signs of raised intracranial pressure caused by an obstructive

  17. Cognición en epilepsia generalizada idiopática: estudio clínico y de vídeo-electroencefalograma

    OpenAIRE

    Abarrategui Yagüe, Belén

    2017-01-01

    Las Epilepsias Generalizadas Idiopáticas (EGI) constituyen una quinta parte de todos los casos de epilepsia. Se trata de un conjunto de síndromes de inicio en la infancia o adolescencia caracterizados por la combinación variable de crisis de ausencia, tónico clónicas generalizadas (TCG) y mioclónicas; por una frecuente sensibilidad a los fármacos antiepilépticos, especialmente el valproato (VPA); y por la presencia de rasgos reflejos como la fotosensibilidad. El hallazgo característico en el ...

  18. A unique case of nontraumatic femoral neck fracture following epilepsia partialis continua

    Directory of Open Access Journals (Sweden)

    Karl O. Nakken

    2015-01-01

    Full Text Available People with epilepsy are more accident prone than the non-epilepsy population. Bone fractures are most often due to seizure-related falls. However, seizures themselves, in particular generalized tonic-clonic seizures, may also cause fractures, e.g. of the thoracic spine. Here, I present a man who developed focal epilepsy following a subarachnoidal hemorrhage. During a focal motor seizure with left-sided convulsions and preserved consciousness that lasted 2 hrs, he sustained a femoral neck fracture. In persons with low mineral density, as in this case, contractions associated with simple focal motor seizures may be sufficient to give rise to such a severe complication.

  19. Epilepsia infantil : descripción clínica, evaluación neuropsicológica y tratamiento

    OpenAIRE

    Andrés Regalado, Alberto

    2015-01-01

    La epilepsia infantil es una condición de salud crónica que afecta a la calidad de vida por múltiples variables como son la frecuencia de las crisis, los fármacos antiepilépticos la frecuencia de las crisis y el tiempo de transcurso de las mismas, la intervención en los periodos infantiles mejoraría la evaluación del sujeto facilitando su adaptación a la vida normal

  20. Fatores preditivos da disfunção sexual em pacientes com diagnóstico de epilepsia

    OpenAIRE

    Vieira, Fábio Cavalcanti de Faria

    2015-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Ciências Médicas, Florianópolis, 2015. A disfunção erétil é relatada com frequência por pacientes com epilepsia e sua etiologia provavelmente é multifatorial, incluindo anormalidades do sistema endocrinológico, efeitos colaterais de fármacos antiepilépticos, comorbidades psiquiátricas e dificuldades familiares e sociais do paciente. Neste trabalho avaliamos a função er...

  1. Reasons for discrepancy between incidence and prevalence of epilepsy in lower income countries: Epilepsia's survey results.

    Science.gov (United States)

    Mathern, Gary W; Beninsig, Laurie; Nehlig, Astrid

    2015-02-01

    From July to August 2014, Epilepsia conducted an online survey seeking opinions that explained the discrepancy between the incidence and prevalence of epilepsy in lower income countries. Data on cumulative incidence suggest a higher rate of active epilepsy than reported in lifetime prevalence surveys. This study reports the findings of that poll addressing the proposal in our Controversy in Epilepsy series that it could be from increased death rates. The survey consisted of a question addressing possible reasons to explain the discrepancy between the incidence and prevalence of epilepsy. Another four questions addressed demographic information. There were 34 responders who completed the survey. Half (50%) of the responders felt that the discrepancy between cumulative incidence and lifetime prevalence was due to lack of uniform definitions and misclassification of patients in study design, 23.5% said the discrepancy was due to a higher mortality from diseases and conditions such as trauma and infections associated with epilepsy, 23.5% indicated that the stigma of epilepsy prevented people from acknowledging their disease in prevalence surveys, and 2.9% felt it was from poor access to qualified medical personal and utilization of medical treatments that increased death rates directly related to epilepsy. Within the limitations of sample size, the results of this survey support that the discrepancy between the incidence and prevalence of epilepsy in lower income regions of the world is due to problems in acquiring the data and stigma rather than higher mortality from diseases associated with epilepsy and repeated seizures. Wiley Periodicals, Inc. © 2014 International League Against Epilepsy.

  2. Sporadic Creutzfeldt-Jakob disease with focal findings: caveats to current diagnostic criteria

    Science.gov (United States)

    Mader, Edward C.; El-Abassi, Rima; Villemarette-Pittman, Nicole R.; Santana-Gould, Lenay; Olejniczak, Piotr W.; England, John D.

    2013-01-01

    The clinical diagnosis of Creutzfeldt-Jakob disease (CJD) is largely based on the 1998 World Health Organization diagnostic criteria. Unfortunately, rigid compliance with these criteria may result in failure to recognize sporadic CJD (sCJD), especially early in its course when focal findings predominate and traditional red flags are not yet present. A 61-year-old man presented with a 3-week history of epilepsia partialis continua (jerking of the left upper extremity) and a 2-week history of forgetfulness and left hemiparesis; left hemisensory neglect was also detected on admission. Repeated brain magnetic resonance imaging (MRI) showed areas of restricted diffusion in the cerebral cortex, initially on the right but later spreading to the left. Electroence-phalography (EEG) on hospital days 7, 10, and 14 showed right-sided periodic lateralized epileptiform discharges. On day 20, the EEG showed periodic sharp wave complexes leading to a diagnosis of probable sCJD and subsequently to definite sCJD with brain biopsy. Neurological decline was relatively fast with generalized myoclonus and akinetic mutism developing within 7 weeks from the onset of illness. CJD was not immediately recognized because of the patient's focal/lateralized manifestations. Focal/lateralized clinical, EEG, and MRI findings are not uncommon in sCJD and EEG/MRI results may not be diagnostic in the early stages of sCJD. Familiarity with these caveats and with the most current criteria for diagnosing probable sCJD (University of California San Francisco 2007, MRI-CJD Consortium 2009) will enhance the ability to recognize sCJD and implement early safety measures. PMID:23717780

  3. Diagnostic imaging in focal epilepsy

    International Nuclear Information System (INIS)

    Zlatareva, D.

    2013-01-01

    Focal epilepsies account for 60% of all seizure disorders worldwide. In this review the classic and new classification system of epileptic seizures and syndromes as well as genetic forms are discussed. Magnetic resonance (MR) is the technique of choice for diagnostic imaging in focal epilepsy because of its sensitivity and high tissue contrast. The review is focused on the lack of consensus of imaging protocols and reported findings in refractory epilepsy. The most frequently encountered MRI findings in epilepsy are reported and their imaging characteristics are depicted. Diagnosis of hippocampal sclerosis and malformations of cortical development as two major causes of refractory focal epilepsy is described in details. Some promising new techniques as positron emission tomography computed tomography (PET/CT) and MR and PET/CT fusion are briefly discussed. Also the relevance of adequate imaging in focal epilepsy, some practical points in imaging interpretation and differential diagnosis are highlighted. (author)

  4. Validación de una encuesta para medir conocimientos y creencias sobre epilepsia, en los padres de familia

    Directory of Open Access Journals (Sweden)

    Miriam Mendoza

    2012-07-01

    Full Text Available La Epilepsia es una enfermedad crónica que en muchos casos se encuentra ligada a conceptos mágico-religiosos que condicionan rechazo social. Objetivo: Elaborar y validar un cuestionario que permita medir el grado de conocimientos y creencias sobre epilepsia en los padres de familia. Material y métodos: Se realizó un estudio transversal para la construcción de un instrumento válido y confiable. Se determinó la validez cualitativa por medio del análisis de expertos y la validez cuantitativa, (confiabilidad y validez interna, a través del cálculo del KR-20, el índice de correlación intraclase y el índice de discriminación, respectivamente. Resultados: El coeficiente KR- 20 fue de 0,89 y el coeficiente de correlación intraclase 0,986, ambos considerados como valores altos. Además, se obtuvo valores para el índice de discriminación de cada ítem dentro de los límites aceptados. Conclusiones: El instrumento elaborado es válido y confiable.

  5. Processamento auditivo em indivíduos com epilepsia de lobo temporal Auditory processing in patients with temporal lobe epilepsy

    Directory of Open Access Journals (Sweden)

    Juliana Meneguello

    2006-08-01

    Full Text Available A epilepsia do lobo temporal ocasiona descargas elétricas excessivas onde a via auditiva tem sua estação final. É uma das formas mais comuns e de mais difícil controle da doença. O correto processamento dos estímulos auditivos necessita da integridade anatômica e funcional de todas as estruturas envolvidas na via auditiva. OBJETIVO: Verificar o Processamento Auditivo de pacientes portadores de epilepsia do lobo temporal quanto aos mecanismos de discriminação de sons em seqüência e de padrões tonais, discriminação da direção da fonte sonora e atenção seletiva para sons verbais e não-verbais. MÉTODO: Foram avaliados oito indivíduos com epilepsia do lobo temporal confirmada e com foco restrito a essa região, através dos testes auditivos especiais: Teste de Localização Sonora, Teste de Padrão de Duração, Teste Dicótico de Dígitos e Teste Dicótico Não-Verbal. O seu desempenho foi comparado ao de indivíduos sem alteração neurológica (estudo caso-controle. RESULTADO: Os sujeitos com epilepsia do lobo temporal apresentaram desempenho semelhante aos do grupo controle quanto ao mecanismo de discriminação da direção da fonte sonora e desempenho inferior quanto aos demais mecanismos avaliados. CONCLUSÃO: Indivíduos com epilepsia do lobo temporal apresentaram maior prejuízo no processamento auditivo que os sem danos corticais, de idades semelhantes.Temporal epilepsy, one of the most common presentation of this pathology, causes excessive electrical discharges in the area where we have the final station of the auditory pathway. Both the anatomical and functional integrity of the auditory pathway structures are essential for the correct processing of auditory stimuli. AIM: to check the Auditory Processing in patients with temporal lobe epilepsy regarding the auditory mechanisms of discrimination from sequential sounds and tone patterns, discrimination of the sound source direction and selective attention to verbal

  6. Caso severo de manifestaciones bucales de la hiperplasia epitelial focal

    OpenAIRE

    Jonathan Harris Ricardo; Natalia Fortich Mesa

    2012-01-01

    La hiperplasia epitelial focal, conocida también como enfermedad de Heck, es una patología benigna que se caracteriza por la presencia de múltiples pápulas en la mucosa de la cavidad bucal; es producida por los subtipos 13 y 32 del virus del papiloma humano, aunque también se le relaciona con factores genéticos, inmunosupresión e higiene bucal deficiente pero con poco sustento científico; afecta principalmente a niños y adolescentes. Se reporta caso clínico de paciente femenina de 7 años de e...

  7. Síndrome convulsivo neonatal: Enfoque diagnóstico a propósito de un caso de epilepsia focal sintomática

    OpenAIRE

    Joaquín Saavedra D.; María José Sierralta S.; Felipe Pinto S.; Cristian Saavedra D.; Francisco Cerda C.

    2012-01-01

    INTRODUCTION: Neonatal seizures are a hypersynchronic depolarizationof a finite set of cortical neurons. The symptomsthat manifest are motor, sensory, autonomic, or mixed. The etiologymust be studied from the beginning. CASE REPORT: Termnewborn, female, 38 weeks gestation, born of vaginal deliverywith Apgar score 9-9. Mother of 24 years, no history or backgroundmorbid during pregnancy. It presents two episodes ofsudden cyanosis boxes discarded at the time of hypoglycemia,hypokalemia, or infec...

  8. Continuously variable focal length lens

    Science.gov (United States)

    Adams, Bernhard W; Chollet, Matthieu C

    2013-12-17

    A material preferably in crystal form having a low atomic number such as beryllium (Z=4) provides for the focusing of x-rays in a continuously variable manner. The material is provided with plural spaced curvilinear, optically matched slots and/or recesses through which an x-ray beam is directed. The focal length of the material may be decreased or increased by increasing or decreasing, respectively, the number of slots (or recesses) through which the x-ray beam is directed, while fine tuning of the focal length is accomplished by rotation of the material so as to change the path length of the x-ray beam through the aligned cylindrical slows. X-ray analysis of a fixed point in a solid material may be performed by scanning the energy of the x-ray beam while rotating the material to maintain the beam's focal point at a fixed point in the specimen undergoing analysis.

  9. Tratamento da epilepsia na infância com mogadon Treatment of epilepsy in children with Mogadon

    Directory of Open Access Journals (Sweden)

    Antonio B. Lefèvre

    1969-06-01

    Full Text Available São analisados os resultados obtidos com o emprego do Mogadon em 68 casos de epilepsia em crianças (34 com síndrome de West, 14 com epilepsia tipo P.M. ausência simples e 20 com formas atípicas de P.M., todos rebeldes aos tratamentos convencionais experimentados em várias combinações, e durante tempo variável, porém quase sempre bastante longo. A maioria dos pacientes apresentava intenso retardamento psicomotor, provavelmente decorrente da longa evolução não controlada da epilepsia. Os resultados foram muito bons no que diz respeito ao controle das crises (100% em 28, 75% em 22, 50% em 10, 25% em um e nulo apenas em 7 casos. O resultado sôbre o desenvolvimento psicomotor foi menos brilhante, pois poucos pacientes melhoraram com o controle das crises. Os efeitos colaterais foram pouco importantes, tendo sido nulos em 41; em 23 foi notada sonolëncia (em dois acompanhada de ataxia; em 4 houve queixa de insônia controlável com barbitúricos. O seguimento após o tratamento variou de 6 a 18 meses.Therapeutic results with Mogadon in 68 children with epilepsy (34 cases of West syndrome, 14 with tipical P.M. seizures, 20 with atypical P.M. seizures resistant to conventional therapy employed previously in various combinations for prolonged periods, is reported. The majority of the patients showed intense psychomotor retardation, probably due to the non-controlled evolution of the cases, before the administration of Mogadon. Results were excellent in regard to the control of the crise's frequency (100% in 28, 75% in 22, 50% in 10, 25% in one, and null in 7 cases. Concerning the psychomotor development the results were less evident. Side effects were negligible, being absent in 41 cases; 23 patients showed somnolence, accompanied by ataxia in two cases. Four patients complained of insomnia, promptly controlled with barbiturates. The period of post-treatment follow-up ranged between 6 and 18 months.

  10. Testing of focal plane arrays

    International Nuclear Information System (INIS)

    Merriam, J.D.

    1988-01-01

    Problems associated with the testing of focal plane arrays are briefly examined with reference to the instrumentation and measurement procedures. In particular, the approach and instrumentation used as the Naval Ocean Systems Center is presented. Most of the measurements are made with flooded illumination on the focal plane array. The array is treated as an ensemble of individual pixels, data being taken on each pixel and array averages and standard deviations computed for the entire array. Data maps are generated, showing the pixel data in the proper spatial position on the array and the array statistics

  11. Epilepsy in patients with psychogenic non-epileptic seizures Epilepsia em pacientes com crises não epilépticas psicogênicas

    Directory of Open Access Journals (Sweden)

    Renato Luiz Marchetti

    2010-04-01

    Full Text Available The aim of this study was to evaluate the frequency of epilepsy in patients who presented psychogenic non-epileptic seizures (PNES. The evaluation was carried out during intensive VEEG monitoring in a diagnostic center for epilepsy in a university hospital. The difficulties involved in reaching this diagnosis are discussed. Ninety-eight patients underwent intensive and prolonged video-electroencephalographic (VEEG monitoring; out of these, a total of 28 patients presented PNES during monitoring. Epilepsy was defined as present when the patient presented epileptic seizures during VEEG monitoring or when, although not presenting epileptic seizures during monitoring, the patient presented unequivocal interictal epileptiform discharges. The frequency of epilepsy in patients with PNES was 50% (14 patients. Our findings suggest that the frequency of epilepsy in patients with PNES is much higher than that of previous studies, and point out the need, at least in some cases, for prolonging the evaluation of patients with PNES who have clinical histories indicating epilepsy.O objetivo deste estudo foi avaliar a frequência de epilepsia em pacientes que apresentaram crises não epilépticas psicogênicas (CNEP. Isto foi realizado durante monitoração intensiva por video-EEG num centro diagnóstico de epilepsia em um hospital universitário. As dificuldades envolvidas para se chegar a este diagnóstico são discutidas. Noventa e oito pacientes foram submetidos a monitoração intensiva por video-EEG; 28 destes pacientes apresentaram CNEP durante a monitoração. Epilepsia foi considerada presente quando o paciente apresentou crises epilépticas durante a avaliação pelo video-EEG ou quando, apesar da não ocorrência de crises epilépticas durante a avaliação, descargas epilépticas interictais inequívocas estavam presentes. A frequência de epilepsia em pacientes com CNEP foi 50% (14 pacientes. Nossos achados sugerem que a frequência de epilepsia em

  12. Percepção do estigma da epilepsia em professores do ensino fundamental Perception of epilepsy stigma in fundamental school teachers

    Directory of Open Access Journals (Sweden)

    Paula Teixeira Fernandes

    2004-04-01

    Full Text Available A epilepsia é uma condição neurológica crônica que traz implicações psicológicas e acadêmicas para a criança, sua família, professores e amigos. Este trabalho teve por objetivo identificar a percepção do estigma da epilepsia em professores, levando-se em consideração os aspectos acadêmicos, psicológicos e culturais desta condição. Para isto, foram distribuídos questionários a respeito da epilepsia para professores do ensino fundamental da rede pública de ensino em Campinas. Diante dos 94 questionários respondidos, observou-se que 91,5% dos professores pesquisados sabem que a epilepsia é uma desordem neurológica; 40,0% acham que o tratamento deve ser feito com acompanhamento médico e 96,8% acreditam que as crianças com epilepsia devem freqüentar escola comum. Em relação às crenças, a que mais apareceu foi o medo da criança engolir a língua durante a crise. Os professores pesquisados mostraram possuir conhecimentos adequados a respeito da epilepsia, o que contradiz o observado nas atitudes sociais encontradas em nossa sociedade, que são caracterizadas por preconceito e estigma.Epilepsy is a common neurological disorder that brings psychological and academic implications to the children, their family, teachers and friends. The purpose of the study was to identify teachers' perception of epilepsy as a stigma, considering the academic, psychological and cultural aspects of this condition. Questionnaires about their knowledge of epilepsy were distributed to teachers of public schools in Campinas, Brazil. From the 94 answered questionnaires, it was observed that 91.5% knew that epilepsy is a neurological disorder, 40.0% thought that the treatment is with medical follow-up, and 96.8% believed that children must study in a normal school. In relation to beliefs, the fear of a child swallowing the tongue during the seizure appeared in 45.7% of teachers' answers. The searched teachers showed that they have adequate

  13. Epilepsia partialis continua present with shoulder joint-trunk-hip joint rhythmic clonic seizure: a case report

    Directory of Open Access Journals (Sweden)

    Lv YD

    2016-09-01

    Full Text Available Yudan Lv, Zan Wang, Fengna Chu, Chang Liu, Hongmei Meng Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, ChangChun, People’s Republic of China Abstract: Epilepsia partialis continua (EPC is a particular type of epilepsy which is distinguished from “common epilepsy” by its characteristic semiological features. However, unusual manifestations should be described in order to give awareness at clinical diagnosis. In this case report we describe a rare EPC case not previously reported, in which left shoulder joint-trunk-hip joint jerk was present for 1 week. Abnormal electroencephalogram and cerebrospinal fluid results supported a diagnosis of viral encephalitis. Antiepileptic treatment seemed effective. Our report emphasizes that a detailed functional anatomical analysis and synchronized electroencephalogram discharge should be done to avoid misdiagnosis in patients with synchronic shoulder-trunk-hip jerk symptoms. Keywords: EPC, shoulder-trunk-hip, EEG, clonic seizure, virus encephalitis

  14. Estudo crítico dos modelos experimentais em epilepsia espontânea do tipo ausência

    OpenAIRE

    Elton Pallone de Oliveira

    2011-01-01

    A epilepsia é uma das afecções neurológica mais comum na população mundial. Trata-se de uma condição crônica altamente incapacitante que acomete indivíduos de ambos os sexos e de todas as faixas etárias, com um discreto predomínio em homens e, maior freqüência em crianças abaixo de dois anos e idosos acima de 65 anos. As conseqüências de morbidade e mortalidade desta patologia repercutem negativamente na sociedade e, conseqüentemente na economia global. Estima-se que de 60 a 100 milhões de pe...

  15. Focal therapy in prostate cancer

    NARCIS (Netherlands)

    van den Bos, W.

    2016-01-01

    Interesting developments took place in the treatment of prostate cancer including focal therapy for less aggressive organ-confined prostate cancer. Fortunately, curative treatment is often still an option for patients suffering from the lower staged tumors. In carefully selected patients, the

  16. Gallbladder adenoma with focal adenocarcinoma.

    Science.gov (United States)

    Ciurea, S; Matei, E; Petrisor, P; Luca, L; Boros, Mirela; Herlea, V; Popescu, I

    2008-01-01

    The majority of polypoid lesions of the gallbladder are cholesterolosis pseudopolyps. True neoplastic GB polyps are represented mainly by adenomas. The case of a 52-year old male patient with an adenomatous polyp of the GB with focal adenocarcinoma is presented.

  17. Charging as a Focal Practice

    DEFF Research Database (Denmark)

    Bødker, Mads

    This position paper reflects on Borgmann’s notion of ‘focal things’ and its applicability in the discourse about interaction with technologies in nature. Using the example of a combined cooking burner and thermoelectric 5W smartphone charger (a BioLite cook stove), this position paper gives...

  18. Termination of seizure clusters is related to the duration of focal seizures.

    Science.gov (United States)

    Ferastraoaru, Victor; Schulze-Bonhage, Andreas; Lipton, Richard B; Dümpelmann, Matthias; Legatt, Alan D; Blumberg, Julie; Haut, Sheryl R

    2016-06-01

    Clustered seizures are characterized by shorter than usual interseizure intervals and pose increased morbidity risk. This study examines the characteristics of seizures that cluster, with special attention to the final seizure in a cluster. This is a retrospective analysis of long-term inpatient monitoring data from the EPILEPSIAE project. Patients underwent presurgical evaluation from 2002 to 2009. Seizure clusters were defined by the occurrence of at least two consecutive seizures with interseizure intervals of <4 h. Other definitions of seizure clustering were examined in a sensitivity analysis. Seizures were classified into three contextually defined groups: isolated seizures (not meeting clustering criteria), terminal seizure (last seizure in a cluster), and intracluster seizures (any other seizures within a cluster). Seizure characteristics were compared among the three groups in terms of duration, type (focal seizures remaining restricted to one hemisphere vs. evolving bilaterally), seizure origin, and localization concordance among pairs of consecutive seizures. Among 92 subjects, 77 (83%) had at least one seizure cluster. The intracluster seizures were significantly shorter than the last seizure in a cluster (p = 0.011), whereas the last seizure in a cluster resembled the isolated seizures in terms of duration. Although focal only (unilateral), seizures were shorter than seizures that evolved bilaterally and there was no correlation between the seizure type and the seizure position in relation to a cluster (p = 0.762). Frontal and temporal lobe seizures were more likely to cluster compared with other localizations (p = 0.009). Seizure pairs that are part of a cluster were more likely to have a concordant origin than were isolated seizures. Results were similar for the 2 h definition of clustering, but not for the 8 h definition of clustering. We demonstrated that intracluster seizures are short relative to isolated seizures and terminal seizures. Frontal

  19. Fewer specialists support using medical marijuana and CBD in treating epilepsy patients compared with other medical professionals and patients: Result of Epilepsia's survey

    OpenAIRE

    Mathern, GW; Beninsig, L; Nehlig, A

    2015-01-01

    © Wiley Periodicals, Inc. © 2014 International League Against Epilepsy. Summary Objective From May 20 to September 1 2014, Epilepsia conducted an online survey seeking opinions about the use of medical marijuana and cannabidiol (CBD) for people with epilepsy. This study reports the findings of that poll. Methods The survey consisted of eight questions. Four questions asked if there were sufficient safety and efficacy data, whether responders would advise trying medical marijuana in cases of s...

  20. [Focal myositis: An unknown disease].

    Science.gov (United States)

    Gallay, L; Streichenberger, N; Benveniste, O; Allenbach, Y

    2017-10-01

    Focal myositis are inflammatory muscle diseases of unknown origin. At the opposite from the other idiopathic inflammatory myopathies, they are restricted to a single muscle or to a muscle group. They are not associated with extramuscular manifestations, and they have a good prognosis without any treatment. They are characterized by a localized swelling affecting mostly lower limbs. The pseudo-tumor can be painful, but is not associated with a muscle weakness. Creatine kinase level is normal. Muscle MRI shows an inflammation restricted to a muscle or a muscle group. Muscle biopsy and pathological analysis remain necessary for the diagnosis, showing inflammatory infiltrates composed by macrophages and lymphocytes without any specific distribution within the muscle. Focal overexpression of HLA-1 by the muscle fibers is frequently observed. The muscle biopsy permits to rule out differential diagnosis such a malignancy (sarcoma). Spontaneous remission occurs within weeks or months after the first symptoms, relapse is unusual. Copyright © 2017. Published by Elsevier SAS.

  1. Myoclonic epilepsy of late onset in trisomy 21 Epilepsia mioclônica de início tardio na trissomia 21

    Directory of Open Access Journals (Sweden)

    Lm. Li

    1995-12-01

    Full Text Available We report the case of a patient with trisomy 21 (T21 with late onset epilepsy. The electro-clinical features were of myoclonic jerks on awakening and generalised tonic clonic seizures, with generalised spike and wave on EEG, and a progressive dementia. As familial Alzheimer's dementia and progressive myoclonic epilepsy (Unverricht-Lundborg type are both linked to the chromosome 21, this case may represent a distinct progressive myoclonic epilepsy related to T21.Pacientes com trissomia do cromossoma 21 (T21, com o passar dos anos, são propensos a desenvolver crises epilépticas parciais concomitantes ao aparecimento de degeneração cerebral do tipo Alzheimer. Pacientes com T21 e demência parecem ter risco maior de apresentarem crises epilépticas que outros pacientes com degeneração cerebral do tipo Alzheimer. O caso relatado é de um paciente com T21 com epilepsia de início tardio. A história clínica consiste de crises mioclônicas ao despertar, ocasionais crises generalizadas tônico-clônicas, demência e ponta onda generalisada no EEG. Demência do tipo Alzheimer familial é ligada ao cromossoma 21, bem como epilepsia mioclônica progressiva (tipo Unverricht-Lundborg. Isto sugere que este caso possa representar um tipo distinto de epilepsia mioclônica progressiva, ligado ao cromossoma 21.

  2. Tilt teste no diagnóstico diferencial da "epilepsia" resistente ao tratamento Tilt table test in the differential diagnosis of refractory "epilepsy"

    Directory of Open Access Journals (Sweden)

    Renata Rodrigues Teixeira de Castro

    2006-11-01

    Full Text Available A epilepsia é uma das causas mais freqüentes de distúrbios neurológicos em adultos jovens. Relatamos um caso em que uma paciente conviveu durante doze anos com o diagnóstico de epilepsia resistente ao tratamento, quando, na verdade, a causa de seus sintomas pôde ser encontrada com a realização do teste de inclinação (tilt teste. O cardiologista deve estar alerta para o possível diagnóstico de síncope neurocardiogênica em pacientes previamente diagnosticados como portadores de epilepsia, especialmente naqueles com difícil controle terapêutico.Epilepsy is one of the most frequent causes of neurological disorders in young adults. We report the case of a patient who lived with the diagnosis of refractory epilepsy for twelve years, when actually the cause of the symptoms could be found with the performance of a tilt table test. Cardiologists should be aware of the possible diagnosis of neurocardiogenic syncope in patients previously diagnosed with epilepsy, especially in those with difficult therapeutic control.

  3. Focal cortical dysplasia – review

    International Nuclear Information System (INIS)

    Kabat, Joanna; Król, Przemysław

    2012-01-01

    Focal cortical dysplasia is a malformation of cortical development, which is the most common cause of medically refractory epilepsy in the pediatric population and the second/third most common etiology of medically intractable seizures in adults. Both genetic and acquired factors are involved in the pathogenesis of cortical dysplasia. Numerous classifications of the complex structural abnormalities of focal cortical dysplasia have been proposed – from Taylor et al. in 1971 to the last modification of Palmini classification made by Blumcke in 2011. In general, three types of cortical dysplasia are recognized. Type I focal cortical dysplasia with mild symptomatic expression and late onset, is more often seen in adults, with changes present in the temporal lobe. Clinical symptoms are more severe in type II of cortical dysplasia usually seen in children. In this type, more extensive changes occur outside the temporal lobe with predilection for the frontal lobes. New type III is one of the above dysplasias with associated another principal lesion as hippocampal sclerosis, tumor, vascular malformation or acquired pathology during early life. Brain MRI imaging shows abnormalities in the majority of type II dysplasias and in only some of type I cortical dysplasias. The most common findings on MRI imaging include: focal cortical thickening or thinning, areas of focal brain atrophy, blurring of the gray-white junction, increased signal on T2- and FLAIR-weighted images in the gray and subcortical white matter often tapering toward the ventricle. On the basis of the MRI findings, it is possible to differentiate between type I and type II cortical dysplasia. A complete resection of the epileptogenic zone is required for seizure-free life. MRI imaging is very helpful to identify those patients who are likely to benefit from surgical treatment in a group of patients with drug-resistant epilepsy. However, in type I cortical dysplasia, MR imaging is often normal, and also in both

  4. Caso severo de manifestaciones bucales de la hiperplasia epitelial focal

    Directory of Open Access Journals (Sweden)

    Jonathan Harris Ricardo

    2012-01-01

    Full Text Available La hiperplasia epitelial focal, conocida también como enfermedad de Heck, es una patología benigna que se caracteriza por la presencia de múltiples pápulas en la mucosa de la cavidad bucal; es producida por los subtipos 13 y 32 del virus del papiloma humano, aunque también se le relaciona con factores genéticos, inmunosupresión e higiene bucal deficiente pero con poco sustento científico; afecta principalmente a niños y adolescentes. Se reporta caso clínico de paciente femenina de 7 años de edad, remitida al servicio de Estomatología y Cirugía Oral de la Corporación Universitaria Rafael Núñez por presentar múltiples pápulas en mucosa bucal, de tamaño variable, asintomáticas, 8 meses de evolución, relacionadas clínicas e histológicamente con hiperplasia epitelial focal.

  5. Estudio de la densidad ósea en niños y adolescentes con afectación moderada y severa por parálisis cerebral

    OpenAIRE

    Tatay Díaz, Ángela

    2016-01-01

    Falta palabras claves El término Parálisis Cerebral describe un grupo de trastornos permanentes del movimiento y la postura que provocan limitación de la actividad y que son secundarios a un daño puntual y no progresivo en el cerebro en desarrollo. Los trastornos motores de la Parálisis Cerebral se acompañan con frecuencia de alteraciones sensitivas, perceptivas, cognitivas, de la comunicación y el comportamiento, epilepsia y problemas secundarios a nivel del sistema musculoesquelético. ...

  6. Systems considerations in mosaic focal planes

    Science.gov (United States)

    White, K. P., III

    1983-08-01

    Two key reasons for pursuing the development of mosaic focal planes are reviewed and it is shown that rapid frame repetition rate is the only requirement that can be solved no other way than through mosaic focal planes. With the view that spaceborne mosaic focal plane sensors are necessarily 'smart sensors' requiring a lot of onboard processing just to function, it is pointed out that various artificial intelligence techniques may be the most appropriate to incorporate in the data processing. Finally, a novel mosaic focal plane design is proposed, termed a virtual mosaic focal plane, in response to other system constraints.

  7. TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly

    Science.gov (United States)

    Uchil, Pradeep D.; Pawliczek, Tobias; Reynolds, Tracy D.; Ding, Siyuan; Hinz, Angelika; Munro, James B.; Huang, Fang; Floyd, Robert W.; Yang, Haitao; Hamilton, William L.; Bewersdorf, Joerg; Xiong, Yong; Calderwood, David A.; Mothes, Walther

    2014-01-01

    ABSTRACT Focal adhesions are macromolecular complexes that connect the actin cytoskeleton to the extracellular matrix. Dynamic turnover of focal adhesions is crucial for cell migration. Paxillin is a multi-adaptor protein that plays an important role in regulating focal adhesion dynamics. Here, we identify TRIM15, a member of the tripartite motif protein family, as a paxillin-interacting factor and a component of focal adhesions. TRIM15 localizes to focal contacts in a myosin-II-independent manner by an interaction between its coiled-coil domain and the LD2 motif of paxillin. Unlike other focal adhesion proteins, TRIM15 is a stable focal adhesion component with restricted mobility due to its ability to form oligomers. TRIM15-depleted cells display impaired cell migration and reduced focal adhesion disassembly rates, in addition to enlarged focal adhesions. Thus, our studies demonstrate a cellular function for TRIM15 as a regulatory component of focal adhesion turnover and cell migration. PMID:25015296

  8. Heterogeneity of Focal Adhesions and Focal Contacts in Motile Fibroblasts.

    Science.gov (United States)

    Gladkikh, Aleena; Kovaleva, Anastasia; Tvorogova, Anna; Vorobjev, Ivan A

    2018-01-01

    Cell-extracellular matrix (ECM) adhesion is an important property of virtually all cells in multicellular organisms. Cell-ECM adhesion studies, therefore, are very significant both for biology and medicine. Over the last three decades, biomedical studies resulted in a tremendous advance in our understanding of the molecular basis and functions of cell-ECM adhesion. Based on morphological and molecular criteria, several different types of model cell-ECM adhesion structures including focal adhesions, focal complexes, fibrillar adhesions, podosomes, and three-dimensional matrix adhesions have been described. All the subcellular structures that mediate cell-ECM adhesion are quite heterogeneous, often varying in size, shape, distribution, dynamics, and, to a certain extent, molecular constituents. The morphological "plasticity" of cell-ECM adhesion perhaps reflects the needs of cells to sense, adapt, and respond to a variety of extracellular environments. In addition, cell type (e.g., differentiation status, oncogenic transformation, etc.) often exerts marked influence on the structure of cell-ECM adhesions. Although molecular, genetic, biochemical, and structural studies provide important maps or "snapshots" of cell-ECM adhesions, the area of research that is equally valuable is to study the heterogeneity of FA subpopulations within cells. Recently time-lapse observations on the FA dynamics become feasible, and behavior of individual FA gives additional information on cell-ECM interactions. Here we describe a robust method of labeling of FA using plasmids with fluorescent markers for paxillin and vinculin and quantifying the morphological and dynamical parameters of FA.

  9. Interferon Induced Focal Segmental Glomerulosclerosis

    Directory of Open Access Journals (Sweden)

    Yusuf Kayar

    2016-01-01

    Full Text Available Behçet’s disease is an inflammatory disease of unknown etiology which involves recurring oral and genital aphthous ulcers and ocular lesions as well as articular, vascular, and nervous system involvement. Focal segmental glomerulosclerosis (FSGS is usually seen in viral infections, immune deficiency syndrome, sickle cell anemia, and hyperfiltration and secondary to interferon therapy. Here, we present a case of FSGS identified with kidney biopsy in a patient who had been diagnosed with Behçet’s disease and received interferon-alpha treatment for uveitis and presented with acute renal failure and nephrotic syndrome associated with interferon.

  10. Focal nodular hyperplasia: imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    Kehagias, D.; Moulopoulos, L.; Antoniou, A.; Hatziioannou, A.; Smyrniotis, V.; Trakadas, S.; Lahanis, S.; Vlahos, L. [Dept. of Radiology, University of Athens (Greece)

    2001-02-01

    Focal nodular hyperplasia is an uncommon benign hepatic tumor that continues to pose diagnostic dilemmas. Imaging techniques are of great value in diagnosis of this tumor. In this article we present the US, CT, MR imaging, scintigraphy, and angiography findings. The demonstration of a central vascular scar is very helpful. Although the radiologic features may be diagnostic, many atypical cases must be differentiated from other benign or malignant hepatic tumors. In these cases excisional biopsy and histopathologic examination are necessary to determine a definite diagnosis. (orig.)

  11. Focal nodular hyperplasia: imaging findings

    International Nuclear Information System (INIS)

    Kehagias, D.; Moulopoulos, L.; Antoniou, A.; Hatziioannou, A.; Smyrniotis, V.; Trakadas, S.; Lahanis, S.; Vlahos, L.

    2001-01-01

    Focal nodular hyperplasia is an uncommon benign hepatic tumor that continues to pose diagnostic dilemmas. Imaging techniques are of great value in diagnosis of this tumor. In this article we present the US, CT, MR imaging, scintigraphy, and angiography findings. The demonstration of a central vascular scar is very helpful. Although the radiologic features may be diagnostic, many atypical cases must be differentiated from other benign or malignant hepatic tumors. In these cases excisional biopsy and histopathologic examination are necessary to determine a definite diagnosis. (orig.)

  12. SNAP Satellite Focal Plane Development

    International Nuclear Information System (INIS)

    Bebek, C.; Akerlof, C.; Aldering, G.; Amanullah, R.; Astier, P.; Baltay, C.; Barrelet, E.; Basa, S.; Bercovitz, J.; Bergstrom, L.; Berstein, G.P.; Bester, M.; Bohlin, R.; Bonissent, A.; Bower, C.; Campbell, M.; Carithers, W.; Commins, E.; Day, C.; Deustua, S.; DiGennaro, R.; Ealet, A.; Ellis, R.; Emmett, W.; Eriksson, M.; Fouchez, D.; Fruchter, A.; Genat, J-F.; Goldhaber, G.; Goobar, A.; Groom, D.; Heetderks, H.; Holland, S.; Huterer, D.; Johnson, W.; Kadel, R.; Karcher, A.; Kim, A.; Kolbe, W.; Lafever, R.; Lamoureaux, J.; Lampton, M.; Lefevre, O.; Levi, M.; Levin, D.; Linder, E.; Loken, S.; Malina, R.; Mazure, A.; McKay, T.; McKee, S.; Miquel, R.; Morgan, N.; Mortsell, E.; Mostek, N.; Mufson, S.; Musser, J.; Roe, N.; Nugent, P.; Oluseyi, H.; Pain, R.; Palaio, N.; Pankow, D.; Perlmutter, S.; Prieto, E.; Rabinowitz, D.; Refregier, A.; Rhodes, J.; Schubnell, M.; Sholl, M.; Smadja, G.; Smith, R.; Smoot, G.; Snyder, J.; Spadafora, A.; Szymkowiak, A.; Tarle, G.; Taylor, K.; Tilquin, A.; Tomasch, A.; Vincent, D.; von der Lippe, H.; Walder, J-P.; Wang, G.

    2003-01-01

    The proposed SuperNova/Acceleration Probe (SNAP) mission will have a two-meter class telescope delivering diffraction-limited images to an instrumented 0.7 square degree field in the visible and near-infrared wavelength regime. The requirements for the instrument suite and the present configuration of the focal plane concept are presented. A two year R and D phase, largely supported by the Department of Energy, is just beginning. We describe the development activities that are taking place to advance our preparedness for mission proposal in the areas of detectors and electronics

  13. MRI of focal cortical dysplasia

    International Nuclear Information System (INIS)

    Lee, B.C.P.; Hatfield, G.A.; Bourgeois, B.; Park, T.S.

    1998-01-01

    We studied nine cases of focal cortical dysplasia (FCD) by MRI, with surface-rendered 3D reconstructions. One case was also examined using single-voxel proton MR spectroscopy (MRS). The histological features were reviewed and correlated with the MRI findings. The gyri affected by FCD were enlarged and the signal of the cortex was slightly increased on T1-weighted images. The gray-white junction was indistinct. Signal from the subcortical white matter was decreased on T1- and increased on T2-weighted images in most cases. Contrast enhancement was seen in two cases. Proton MRS showed a spectrum identical to that of normal brain. (orig.) (orig.)

  14. Presentación de un caso de aplicación de la dieta cetogénica en la epilepsia refractaria Presentation of a case of ketogenic diet application to refractory epilepsy

    Directory of Open Access Journals (Sweden)

    Ligia M Marcos Plasencia

    2007-12-01

    Full Text Available Se presenta el caso de un paciente del sexo masculino, de 2 años de edad, que padece síndrome de West y que ha recibido tratamiento con múltiples drogas antiepilépticas sin obtener resultados alentadores ni en las crisis ni en su desarrollo psicomotor, seriamente afectado. Se establece el régimen de alimentación cetogénico de instalación progresiva, sin período de ayuno inicial, y se observa un cambio clínico en el paciente a partir de que se logran niveles de cetosis, constatados por la aparición de cuerpos cetónicos en la orina. Los cambios clínicos consisten en la disminución del número de crisis diarias y de su intensidad, en la posibilidad de suspender una de las drogas antiepilépticas que usaba, y en el aumento del nivel de vigilia del paciente. Se concluye que no se debe renunciar a esta alternativa de tratamiento en los casos de epilepsia refractaria.The case of a 2-year-old male patient suffering from West syndrome that had been treated with multiple antiepileptic drugs without encouraging results, neither in the seizures, nor in his psychomotor development, which was seriously affected, was reported. A progressive ketogenic diet was established without initial fasting, and it was observed a clinical change in the patient, since ketosis levels were attained and confirmed by the appearance of ketone bodies in urine. The clinical changes consisted in the reduction of the number of daily seizures and their intensity, in the possibility of stopping the use of one of the antiepileptic drugs, and in the increase of the level of sleeplessness of the patient. It was concluded that this treatment alternative should not be rejected in the cases of refractory epilepsy.

  15. Pathogenesis of Focal Segmental Glomerulosclerosis

    Directory of Open Access Journals (Sweden)

    Beom Jin Lim

    2016-11-01

    Full Text Available Focal segmental glomerulosclerosis (FSGS is characterized by focal and segmental obliteration of glomerular capillary tufts with increased matrix. FSGS is classified as collapsing, tip, cellular, perihilar and not otherwise specified variants according to the location and character of the sclerotic lesion. Primary or idiopathic FSGS is considered to be related to podocyte injury, and the pathogenesis of podocyte injury has been actively investigated. Several circulating factors affecting podocyte permeability barrier have been proposed, but not proven to cause FSGS. FSGS may also be caused by genetic alterations. These genes are mainly those regulating slit diaphragm structure, actin cytoskeleton of podocytes, and foot process structure. The mode of inheritance and age of onset are different according to the gene involved. Recently, the role of parietal epithelial cells (PECs has been highlighted. Podocytes and PECs have common mesenchymal progenitors, therefore, PECs could be a source of podocyte repopulation after podocyte injury. Activated PECs migrate along adhesion to the glomerular tuft and may also contribute to the progression of sclerosis. Markers of activated PECs, including CD44, could be used to distinguish FSGS from minimal change disease. The pathogenesis of FSGS is very complex; however, understanding basic mechanisms of podocyte injury is important not only for basic research, but also for daily diagnostic pathology practice.

  16. RTG diagnostics of dental focal infection

    International Nuclear Information System (INIS)

    Petrasova, A.; Ondrasovicova, J.; Cecctkova, A.

    2008-01-01

    The theory of focal infection has always been and still is a controversial issue for many dentists and scientists. Even though the focal infection does not occupy the first place in modern medicine, its understanding is imperative. The authors summarized the knowledge about dental focal infection and its relationship to systemic the diseases of the whole body in their publication and they also focused on the radiodiagnostics of this disease. (authors)

  17. Periodontitis in patients with focal tuberculosis

    Directory of Open Access Journals (Sweden)

    Alexandrova Е.А.

    2010-12-01

    Full Text Available The research goal is to investigate the mechanisms of formation and peculiarities of periodontitis in patients with focal tuberculosis. Patients with periodontitis and focal tuberculosis are proved to develop local inflammatory reaction with increased infection and activation of proinflammatory cytokines in parodontal pockets fluid. The main risk factor of frequent and durable recurrence of parodontal pathology in case of focal tuberculosis was the development of pathologic process as a cause of disbalance of lipid peroxidation and antioxidant system, endotoxicosis syndrome

  18. Flux dynamics in ultrasensitive superconducting focal planes

    Data.gov (United States)

    National Aeronautics and Space Administration — The performance of superconducting focal planes will drive the achievable specifications of ultrasensitive instruments for NASA astrophysics missions, yet they have...

  19. Game Movement as Enactive Focalization

    Directory of Open Access Journals (Sweden)

    Yotam Shibolet

    2018-01-01

    Full Text Available This paper integrates thought on game narrative and embodied cognition, in order to consider the significance of movement to the embodied narrative experience of games. If games are a mode of ‘environmental storytelling’, determining the player’s mobile situatedness within the gamespace is of crucial importance. The metaphor of game design as narrative architecture should be expanded to include te the design of movement dynamics, alongside geographical gamespace. I suggest a theoretical infrastructure that aims to enable further analysis of movement design’s role in this scope. The theory of enactive perception asserts that all perception is inherently negotiated through embodied understanding of moving within environment. According to this model, by giving meaning to perception, movement is also directly related to the structure of consciousness and thought. Cognitive definitions of ‘narrative’ that integrate embodiment are applied to argue it can relevantly account for part of thought’s role in enactive perception. Mieke Bal’s concept of focalization (1997 broaches narrative perspective by underscoring the constant “movement of the look”. For enactive perception, such mobility should be understood as inseparable from the movement of the body even when perspective could appear detached from embodiment. Therefore, I offer the supplementary concept of “enactive focalization” – narrative perception as interpreted through the interconnected dynamics or perspectival and physical movement. To exemplify my ideas and the potential of future research in this scope, I discuss the uniquely effective and affective movement dynamic design of Journey. This paper concludes by reflecting on enactive focalization in light of the increased utilization of embodiment in the contemporary digital media landscape.

  20. O uso do grupo focal em pesquisa qualitativa

    Directory of Open Access Journals (Sweden)

    Lúcia Beatriz Ressel

    2008-01-01

    Full Text Available Este estudio tuvo como objetivo presentar el uso del grupo focal como técnica de recolección de datos en una tesis de doctorado, resultado de una investigación cualitativa. El grupo focal utiliza sesiones grupales de discusión, teniendo como foco central un tópico específico a ser debatido por los participantes. La investigación focalizó la temática de la sexualidad en la asistencia de enfermería, bajo una perspectiva cultural, siendo desarrollada con dos grupos de enfermeras: docentes y asistenciales. Comprendió ocho encuentros, y cada uno fue planeado por separado. La evaluación del proceso se realizó por medio de entrevistas con las enfermeras, destacando como puntos positivos la conducción hacia el pensamiento crítico y al proceso de desalineación; y la posibilidad de que esta técnica revele significados singulares y a que ellos se relacionen desde el punto de vista de los sujetos investigados. Esa técnica facilitó el abordaje de la sexualidad, desconstruyendo y reconstruyendo conceptos y buscando respuestas para las inquietudes del tema.

  1. SPECT cerebral intervencionista en la valoración prequirúrgica de la epilepsia

    OpenAIRE

    Setoain Perego, Xavier

    2003-01-01

    Los pacientes con crisis parciales complejas farmacorresistentes localizadas en el lóbulo temporal, pueden beneficiarse del tratamiento quirúrgico mediante una lobectomía temporal parcial. Por la exéresis del hipocampo, la principal secuela a evitar de esta intervención es la pérdida de memoria. Por ello, antes de la cirugía se les realiza el test de Wada o test del Amobarbital sódico (TAS) para lateralizar las funciones de memoria y lenguaje. El TAS precisa de una arteriografía carotidea, pa...

  2. UTILIZAÇÃO DE PLANTAS MEDICINAIS NO TRATAMENTO E/OU PREVENÇÃO DA EPILEPSIA: UMA PROSPECÇÃO TECNOLÓGICA

    Directory of Open Access Journals (Sweden)

    AnaPaula Santos Correia Lima da Silva

    2014-09-01

    Full Text Available Nos últimos anos houve um aumento na busca por novos agentes terapêuticos utilizando plantas medicinais para o tratamento de distúrbios psiquiátricos, por isso estudos com fitoterápicos estão sendo bastante reconhecidos como uma perspectiva nos tratamentos de doenças neurodegenerativas. Entre essas patologias pode ser descrita a epilepsia um dos distúrbios neurológicos mais comuns, apresentando uma taxa de prevalência de 5%. Partido deste contexto, o objetivo deste trabalho foi realizar um rastreamento das pesquisas já desenvolvidas e com resultados patenteados, avaliando as utilizações de plantas medicinais no manejo dos sintomas clínicos da epilepsia por meio do mapeamento de patentes nas bases de dados do Instituto Nacional de Propriedade Industrial (INPI, Organização Mundial de Propriedade Intelectual (WIPO, Banco Europeu de Patentes (EPO e no Banco Americano de Marcas e Patentes (USPTO. Foi possível observar um pequeno número de patentes relacionadas às plantas medicinais e sua aplicabilidade no tratamento da epilepsia. Foi verificado também que nos últimos 10 anos o número de pedidos de patentes depositados nas bases PCT e EPO representa 51 e 45%, respectivamente, do total de patentes existente, estando alocadas principalmente na subclasse A61K (preparações para finalidades médicas, odontológicas ou higiênicas. No entanto, é grande a necessidade de descoberta de novas opções terapêuticas no tratamento da epileptogênese. Sendo, assim, há uma lacuna tecnológica a ser preenchida e um campo promissor para pesquisa e desenvolvimento de inovações tecnológicas.

  3. Inventário simplificado de qualidade de vida na epilepsia infantil: primeiros resultados Simplified inventory of quality of life in childhood epilepsy: initial results

    Directory of Open Access Journals (Sweden)

    PAULA TEIXEIRA FERNANDES

    1999-03-01

    Full Text Available OBJETIVO: Verificar como os pais percebem a qualidade de vida dos filhos epilépticos e se crenças relativas à epilepsia controlam a relação pais e filhos. MÉTODO: Foram aplicados 21 protocolos do "Inventário Simplificado de Qualidade de Vida na Epilepsia Infantil" em pais de crianças com 6 a 14 anos portadoras de epilepsia benigna da infância. RESULTADOS: Observou-se que 86% dos pais relataram crenças relativas à epilepsia. A maioria dos pais avaliou a qualidade de vida dos filhos como muito boa, mas relataram dificuldades no lidar com eles. Aparecem comportamentos de superproteção (62% e sentimentos de preocupação, medo e insegurança (90%. As crianças foram avaliadas como irritadas (52%, dependentes (38%, agitadas e inquietas (38%. No que diz respeito à escola, 33% das crianças freqüentam escolas especiais e apresentam dificuldades escolares e de relacionamento. CONCLUSÃO: Crenças e desinformação parecem controlar o comportamento dos pais na maneira de lidar com seus filhos epilépticos, gerando comportamentos inadequados, apesar disto, percebem a qualidade de vida dos mesmos como muito boa.PURPOSE: to check how parents realize the quality of life of their epileptic children and if the relationship is controlled by their beliefs about epilepsy. METHOD: it has been applied 21 protocols of "Simplified inventory of quality of life in childhood epilepsy" to parents of children aged between 6-14 years old with benign childhood epilepsy. RESULTS: it was observed that 86% of parents evaluated their children's quality of life as very good, but reported difficulties to deal with them. Behaviors of overprotection (62% and feelings of worry, fear and insecurity (90% were observed. The children were evaluated as irritated (52%, dependents (38%, overwroughts and inquiets (38%. About school, 33% are in special schools and have difficulties of academic and relationship. CONCLUSION: it was verified a lot of beliefs and acknowledgement

  4. Dieta cetogênica para epilepsia intratável em crianças e adolescentes: relato de seis casos

    OpenAIRE

    Vasconcelos,Marcio M.; Azevedo,Patricia M. Couto; Esteves,Lívia; Brito,Adriana R.; Olivaes,Maria Cecílea D. de; Herdy,Gesmar V. Haddad

    2004-01-01

    OBJETIVO: Descrever a introdução e o manejo da dieta cetogênica em um grupo de seis crianças e adolescentes com epilepsia refratária. MÉTODOS: Os autores reviram o prontuário médico de cada paciente menor de 15 anos submetido à dieta cetogênica entre abril de 1999 e julho de 2003 e compararam os resultados terapêuticos e efeitos adversos e benéficos com a literatura pertinente. RESULTADOS: A dieta cetogênica foi introduzida para seis pacientes, com idade mediana de sete anos (faixa: 1,8-12,2)...

  5. Prenatal sonographic diagnosis of focal musculoskeletal anomalies

    Energy Technology Data Exchange (ETDEWEB)

    Ryu, Jung Kyu; Cho, Jeong Yeon; Lee, Young Ho; Kim, Ei Jeong; Chun, Yi Kyeong [Samsung Cheil Hospital, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2002-09-15

    Focal musculoskeletal anomalies are various and may be an isolated finding or may be found in conjunction with numerous associations, including genetic syndromes, Karyotype abnormals, central nervous system anomalies and other general musculoskeletal disorders. Early prenatal diagnosis of these focal musculoskeletal anomalies nor only affects prenatal care and postnatal outcome but also helps in approaching other numerous associated anomalies.

  6. Prenatal sonographic diagnosis of focal musculoskeletal anomalies

    International Nuclear Information System (INIS)

    Ryu, Jung Kyu; Cho, Jeong Yeon; Lee, Young Ho; Kim, Ei Jeong; Chun, Yi Kyeong

    2002-01-01

    Focal musculoskeletal anomalies are various and may be an isolated finding or may be found in conjunction with numerous associations, including genetic syndromes, Karyotype abnormals, central nervous system anomalies and other general musculoskeletal disorders. Early prenatal diagnosis of these focal musculoskeletal anomalies nor only affects prenatal care and postnatal outcome but also helps in approaching other numerous associated anomalies.

  7. Dieta cetogênica no tratamento de epilepsias farmacorresistentes The ketogenic diet on the treatment of drug resistant epilepsies

    Directory of Open Access Journals (Sweden)

    Carla Barbosa Nonino-Borges

    2004-12-01

    Full Text Available A epilepsia é uma condição clínica crônica correspondente a um grupo de doenças que tem em comum crises epilépticas; ela atinge de 0,5% a 1,0% da população dos países desenvolvidos, podendo esta prevalência ser maior nos países em desenvolvimento. Aproximadamente um terço dos pacientes evolui com crises epilépticas intratáveis com medicamentos; em alguns casos, é possível o tratamento cirúrgico. Nos pacientes em que cirurgia não é possível, a dieta cetogênica passa a ser uma opção terapêutica, principalmente em crianças. Espera-se que esta terapia seja eficaz para, pelo menos, um terço dos pacientes, resultando em redução ou controle das crises. No presente trabalho, apresentamos métodos para o preparo e uso a dieta cetogênica. O planejamento da dieta é individualizado, seguindo-se recomendações para o consumo energético e proporções de gorduras, proteínas e carboidratos específicos. Sempre que introduzida a dieta, o paciente deve ser monitorizado, devido à possibilidade de efeitos adversos. A orientação dos pais ou responsáveis sobre a dieta cetogênica, e como ela funciona, proporciona maior aceitação e aderência a esta forma de tratamento da epilepsia.Epilepsy is a chronic condition that affects 0.5% to 1.0% of the population in developed countries. This prevalence may be higher in developing countries. A significant proportion of the patients, nearly one third of them will have their condition evolved into a stage of uncontrolled crises, in some cases, surgical procedure may be indicated. However, for several patients, surgery is not possible. In these cases, ketogenic diet is a therapeutic option, especially for children. It is supposed that nearly one third of the patients that use the ketogenic diet, experience seizure control or reduction in the number of seizures. The current study presents methods of preparing and using ketogenic diet. The diet must be individualized, considering the

  8. Possíveis interfaces entre TDAH e epilepsia Possible interfaces between attention deficit hyperactivity disorder and epilepsy

    Directory of Open Access Journals (Sweden)

    Karina Soares Loutfi

    2010-01-01

    Full Text Available OBJETIVO: Identificar na literatura elementos para explicar uma possível associação entre o transtorno de déficit de atenção e hiperatividade (TDAH e a epilepsia e orientar quanto ao manejo clínico dos pacientes que compartilham esses transtornos. MÉTODOS: Realizou-se revisão da literatura dos últimos 10 anos nas bases de dados MedLine e Lilacs com a combinação dos descritores "attention deficit hyperactivity disorder", "ADHD" e "epilepsy". RESULTADOS: Sintomas de TDAH são frequentes em síndromes epilépticas idiopáticas. Vários fatores podem contribuir para a coexistência desses transtornos: 1 possibilidade de uma mesma propensão genética; 2 participação dos neurotransmissores noradrenalina e dopamina no TDAH e na modulação da excitabilidade neuronal; 3 anormalidades estruturais do cérebro evidenciadas em epilépticos portadores de TDAH; 4 influência dos efeitos crônicos das crises e das descargas epileptiformes interictais sob a atenção; 5 efeitos adversos das drogas antiepilépticas sob a cognição. CONCLUSÕES: As evidências atuais apontam que crises epilépticas e TDAH podem apresentar bases neurobiológicas comuns. Estudos que avaliam disfunções nas vias de sinalização das catecolaminas cerebrais e o papel das descargas epileptiformes interictais na geração dos sintomas são fundamentais na investigação desses mecanismos. Drogas psicoestimulantes são seguras e eficazes para o tratamento do TDAH na maioria dos portadores de epilepsia.OBJECTIVE: To investigate in the literature elements that explain the association between the attention deficit hyperactivity disorder (ADHD and epilepsy and to provide clinical guidelines for the management of patients that share these disorders. METHODS:Review of literature of the last 10 years in MedLine and Lilacs databases. The keywords used were "attention deficit hyperactivity disorder", "ADHD" and "epilepsy. RESULTS: Symptoms of ADHD are more frequent in idiopathic

  9. Early vision and focal attention

    Science.gov (United States)

    Julesz, Bela

    1991-07-01

    At the thirty-year anniversary of the introduction of the technique of computer-generated random-dot stereograms and random-dot cinematograms into psychology, the impact of the technique on brain research and on the study of artificial intelligence is reviewed. The main finding-that stereoscopic depth perception (stereopsis), motion perception, and preattentive texture discrimination are basically bottom-up processes, which occur without the help of the top-down processes of cognition and semantic memory-greatly simplifies the study of these processes of early vision and permits the linking of human perception with monkey neurophysiology. Particularly interesting are the unexpected findings that stereopsis (assumed to be local) is a global process, while texture discrimination (assumed to be a global process, governed by statistics) is local, based on some conspicuous local features (textons). It is shown that the top-down process of "shape (depth) from shading" does not affect stereopsis, and some of the models of machine vision are evaluated. The asymmetry effect of human texture discrimination is discussed, together with recent nonlinear spatial filter models and a novel extension of the texton theory that can cope with the asymmetry problem. This didactic review attempts to introduce the physicist to the field of psychobiology and its problems-including metascientific problems of brain research, problems of scientific creativity, the state of artificial intelligence research (including connectionist neural networks) aimed at modeling brain activity, and the fundamental role of focal attention in mental events.

  10. The Wada test with propofol in a patient with epilepsy Teste de Wada com propofol em uma paciente com epilepsia

    Directory of Open Access Journals (Sweden)

    TICYANA M. SILVA

    2000-06-01

    Full Text Available The usual drug used in the Wada test is amobarbital, but it is not available in Brazil. Propofol was already used by Bazin et al. in 1998, and in their report the test resulted good in the absence of any adverse effect. We report the use of propofol as the anesthetic for the Wada test. The test was carried out in a 26 years old woman with temporal medial lobe epilepsy refractory to medical treatment. Language functions and memory were tested after injection in both hemispheres by three procedures (Seattle, Montreal and Interview procedures. Propofol showed to be good to carry on the Wada test.O amobarbital é a droga usada no teste de Wada, mas não é disponível em nosso pais. O propofol, usado por Bazin et al. em 1998, foi útil e sem efeitos adversos. Relatamos o uso do propofol como anestésico no teste de Wada. Este foi realizado como parte da avaliação pre-cirúrgica, em uma mulher de 26 anos com epilepsia do lobo temporal mesial, em uso de carbamazepina e ácido valpróico sem controle de suas crises. As funções da linguagem e memória foram testadas após injeção em ambos hemisférios separadamente por três procedimentos (Seattle, Montreal e Entrevista. O propofol mostrou-se eficaz para a realização do teste de Wada.

  11. Pyridoxine-dependent epilepsy initially responsive to phenobarbital Epilepsia por dependência de piridoxina inicialmente responsiva ao fenobarbital

    Directory of Open Access Journals (Sweden)

    Jaime Lin

    2007-12-01

    Full Text Available Pyridoxine-dependent epilepsy is a rare autossomal recessive disorder characterized by recurrent seizures that are not controlled by anticonvulsant medications but remits after administration of pyridoxine. We report on a 30 day-old girl who presented with seizures during the first day of life, initially responsive to anticonvulsant therapy, which remitted within two weeks. Seizures were characterized as multifocal myoclonic jerks of upper and lower limbs associated with buccal-lingual oral movements and eyelid blinking. Laboratory and neuroimaging studies were normal. Electroencephalographic record demonstrated a abnormal background activity with high-voltage epileptic discharges and a burst-suppression pattern. The seizures ceased after oral administration of pyridoxine, but recurred after withdrawal, confirming the diagnosis.A epilepsia por dependência de piridoxina é uma doença autossômica recessiva rara caracterizada por crises recorrentes refratárias a tratamento medicamentoso, mas que remitem após a administração de piridoxina. Relatamos o caso de menina de 30 dias de vida que iniciou crises convulsivas desde o primeiro dia de vida, inicialmente responsivas a tratamento com drogas anticonvulsivantes, mas que reiniciaram após a segunda semana de vida. As crises eram caracterizadas por movimentos clônicos erráticos de membros superiores e inferiores associados a movimentos oromandibulares e piscamentos. Exames laboratoriais e de neuroimagem foram normais. O exame eletrencefalográfico evidenciou atividade de base desorganizada com descargas epilépticas de alta voltagem associadas a um padrão de surto-supressão. As crises cessaram após a administração de piridoxina e recorreram após a sua retirada, confirmando o diagnóstico.

  12. Core biopsy as a simple and effective diagnostic tool in head and neck focal myositis.

    Science.gov (United States)

    Tan, Chun Yee; Chong, Sheldon; Shaw, Chi-Kee Leslie

    2015-12-01

    Most unilateral head and neck masses are benign, although malignancy is a possibility in some cases. However, there are other rare causes of unilateral neck masses, such as focal myositis, which is a rare, benign condition belonging to the family of inflammatory pseudotumors of the skeletal muscles, with rare presentations in the head and neck region. Focal myositis presents as a rapidly enlarging neck mass that can be misdiagnosed by fine-needle aspiration biopsy and/or radiologic imaging as either an infective or a neoplastic process. To date, there are only 5 reported cases of adult focal myositis of the sternocleidomastoid muscle in the medical literature. In this article, the authors present 2 cases involving patients with focal myositis of the sternocleidomastoid muscle that were successfully diagnosed with core-needle biopsy and managed conservatively. The pros and cons of fine-needle aspiration biopsy and core-needle biopsy are discussed. Based on the authors' results, fine-needle aspiration biopsy universally fails to provide the diagnosis of focal myositis. In contrast, core-needle biopsy successfully diagnosed focal myositis in both of our patients. Both of them had complete resolution with conservative management.

  13. Epilepsia"Petit Mal" aspectos clínicos, eletrencefalográficos e evolutivos

    Directory of Open Access Journals (Sweden)

    Paulo Pinto Pupo

    1961-01-01

    Full Text Available In the past few years somewhat new yet often differing points of view have been affirmed refering to Petit Mal epilepsy, with regard to its clinical, eletrencephalographic and evolutive aspects. The classical concept of PM epilepsy as established by Lennox and Gibbs, with its well defined clinical and EEGraphic characteristics is continually being modified with new research work on clinical and EEGraphic aspects. Numerous clinical cases have been published whose evolution clashes with that classically described and likewise numerous are those cases where the EEG shows signs of focal electric activity besides spike and wave dis-rythmia. Cases have been known where surgical exerese on the focus causes temporary desappearance of the spike and wave disrythmia. The present concept now holding sway is that PM epilepsy is a kind of reaction of infantile encephalon to diverse harmful causes. From this it will be seen we are very far from the concept that PM epilepsy is a pure form of idiopathic epilepsy. For these reasons we decided to re-examine those cases observed between 1950 and 1960. With this in mind we chose 141 PM epilepsy cases, from among over 23000 epileptics, all examined under a standard criterion by a small group of senior assistants. All cases suspected of Psm epilepsy were excluded. The analysis of this group of patients was compared to that of another group with GM as well as PM seizures (104 patients; in 52 of these cases, studies were made concerning the evolutive, clinical and EEGra-phic aspects. METHOD: Clinical criterion was used for selection of the cases. The results of the analysis from the clinical and EEGraphic point of view were exhibited in demonstrative graphs. From the clinical point of view we strove to find out positive hereditary elements, organic cerebral injury factor (intellectual deficit, mood and behaviour disturbances, neurologic or somatic signs, as well as other development anomalies, the presence of febrile

  14. Diagnóstico e tratamento de epilepsia e crises pseudoepilépticas psicogênicas associadas: relato de caso

    Directory of Open Access Journals (Sweden)

    Marchetti Renato Luiz

    2001-01-01

    Full Text Available Relatamos o caso de uma paciente de 26 anos em que é evidenciada a importância médica do diagnóstico diferencial entre epilepsia e crises pseudo-epilépticas psicogênicas (CPEP e do seu tratamento. A paciente, uma professora desempregada, com crises desde os 13 anos, foi encaminhada ao PROJEPSI para diagnóstico e tratamento de CPEP. Seu diagnóstico inicial foi de epilepsia parcial sintomática por lesão tumoral cística em região occipto-temporal esquerda, associada a CPEP. Submetida a craniotomia occipital com ressecção de processo expansivo em região de istmo do cíngulo, evoluiu com persistência das CPEP. Submetida a tratamento psicológico integrado envolvendo técnicas de condicionamento operante, manejo de ansiedade, sugestão e orientação familiar, houve remissão completa das CPEP após 4 meses de tratamento. O caso apresentado demonstra a necessidade de múltiplos procedimentos diagnósticos e terapêuticos e a participação de equipe multidisciplinar especializada.

  15. El virus HHV-6 y su relación con los trastornos del neurodesarrollo.

    Directory of Open Access Journals (Sweden)

    Alma Dzib Goodin

    2012-01-01

    Full Text Available Casos / Brief Report Resumen El virus HHV-6 es parte de la familia de los herpesvirus y se encuentra presente en la mayoría de los humanos, aunque sólo se activa para atacar a su huésped en casos donde se presenta inmunodepresión. Posee dos subtipos que se diferencian por el tamaño y la forma de infección que son el HHV-6A y el HHV-6B. En los recién nacidos, se le ha detectado y relacionado con trastornos neuro pediátricos desde hace más de 15 años. Principalmente se le relaciona con la epilepsia benigna, las convulsiones febriles, la encefalitis, la meningoencefalitis, la meningitis y la esclerosis multiple. Actualmente el virus se evoca en estudios de caso relacionados con los trastornos del neurodesarrollo, debido a que éste puede atacar el Sistema Nervioso Central. El daño causado se manifestaría a largo plazo a través de una presentación sintomática similar a lo que se observa por ejemplo en los trastornos del espectro autista. Este artículo busca analizar la presencia del virus y su relación con los trastornos del desarrollo en infantes alrededor del mundo.

  16. Ludopatía y epilepsia en demencia frontotemporal: Reporte de dos casos

    Directory of Open Access Journals (Sweden)

    Sheila Castro-Suarez

    Full Text Available RESUMEN La demencia frontotemporal es un trastorno neurodegenerativo cuyo subtipo más común es la variante conductual. Es considerada la causa de demencia más frecuente en menores de 60 años. Se presentan dos casos no emparentados cuyos síntomas típicos fueron: deterioro progresivo de la cognición, del comportamiento, alteraciones psiquiátricas como desinhibición, actos impulsivos, apatía, falta de empatía, estereotipias y cambios en los hábitos de alimentación. La resonancia magnética cerebral, en ambos casos, mostró atrofia frontotemporal a predominio izquierdo; en la evaluación neuropsicológica se evidenció alteraciones de las funciones ejecutivas. El primer caso cursó con ludopatía como síntoma inicial, motivo por el cual permaneció por un año en un centro psiquiátrico, siendo el segundo en Latinoamérica y uno de los pocos casos reportados en el mundo. El segundo caso presentó crisis epilépticas en su evolución.

  17. Do focal colors look particularly "colorful"?

    Science.gov (United States)

    Witzel, Christoph; Franklin, Anna

    2014-04-01

    If the most typical red, yellow, green, and blue were particularly colorful (i.e., saturated), they would "jump out to the eye." This would explain why even fundamentally different languages have distinct color terms for these focal colors, and why unique hues play a prominent role in subjective color appearance. In this study, the subjective saturation of 10 colors around each of these focal colors was measured through a pairwise matching task. Results show that subjective saturation changes systematically across hues in a way that is strongly correlated to the visual gamut, and exponentially related to sensitivity but not to focal colors.

  18. Focal pancreatic enlargement: differentiation between pancreatic adenocarcinoma and focal pancreatitis on CT and ERCP

    International Nuclear Information System (INIS)

    Kim, Eun Kyung; Kim, Ki Whang; Lee, Jong Tae; Kim, Hee Soo; Yoo, Hyung Sik; Yu, Jeong Sik; Yoon, Sang Wook

    1995-01-01

    To differentiate the pancreatic adenocarcinoma from focal pancreatitis on CT and ERCP in cases of focal pancreatic enlargement. We analysed CT findings of 66 patients of pancreatic adenocarcinoma (n = 45) or focal pancreatitis (n = 21) with respect to size, density, calcification, pancreatic or biliary duct dilatation, fat plane obliteration around the vessels, direction of retroperitoneal extension, lymphadenopathy, pseudocyst formation and atrophy of pancreas. ERCP available in 48 patients were analysed in respect to morphologic appearance of CBD and pancreatic duct, and distance between the two ducts. The patients in focal pancreatitis were younger with more common history of alcohol drinking. There was no statistical difference in calcifications of the mass (18% in the adenocarcinoma, 33% in the focal pancreatitis), but a tendency of denser, larger number of calcifications was noted in focal pancreatitis. The finding of fat plane obliteration around the vessels were more common in pancreatic adenocarcinoma, and fascial thickenings were more prominent in focal pancreatitis, although not statistically significant. On ERCP, there were no differential points of CBD, pancreatic duct morphology, but distance between the two ducts at the lesion center was more wider in focal pancreatitis. Differentiating focal pancreatitis from pancreatic adenocarcinoma is difficult. However, we should consider the possibility of focal pancreatitis in cases of patients with young age, having alcoholic history in association with CT findings of large numbers of and dense calcifications, and ERCP findings of prominent separation of two duct at the lesion center

  19. Focal skin defect, limb anomalies and microphthalmia.

    NARCIS (Netherlands)

    Jackson, K.E.; Andersson, H.C.

    2004-01-01

    We describe two unrelated female patients with congenital single focal skin defects, unilateral microphthalmia and limb anomalies. Growth and psychomotor development were normal and no brain malformation was detected. Although eye and limb anomalies are commonly associated, clinical anophthalmia and

  20. Focal adhesions and cell-matrix interactions

    DEFF Research Database (Denmark)

    Woods, A; Couchman, J R

    1988-01-01

    Focal adhesions are areas of cell surfaces where specializations of cytoskeletal, membrane and extracellular components combine to produce stable cell-matrix interactions. The morphology of these adhesions and the components identified in them are discussed together with possible mechanisms...

  1. Genetics Home Reference: focal dermal hypoplasia

    Science.gov (United States)

    ... in people with focal dermal hypoplasia is an omphalocele , which is an opening in the wall of ... Dermal Hypoplasia MedlinePlus Encyclopedia: Ectodermal dysplasia MedlinePlus Encyclopedia: Omphalocele General Information from MedlinePlus (5 links) Diagnostic Tests ...

  2. Focal lesions in the central nervous system

    International Nuclear Information System (INIS)

    Fabrikant, J.I.; Budinger, T.F.; Tobias, C.A.; Born, J.L.

    1980-01-01

    This report reviews the animal and human studies currently in progress at LBL with heavy-ion beams to induce focal lesions in the central nervous system, and discusses the potential future prospects of fundamental and applied brain research with heavy-ion beams. Methods are being developed for producing discrete focal lesions in the central nervous system using the Bragg ionization peak to investigate nerve pathways and neuroendocrine responses, and for treating pathological disorders of the brain

  3. Pathophysiology of mood disorders in temporal lobe epilepsy Fisiopatologia dos transtornos de humor na epilepsia do lobo temporal

    Directory of Open Access Journals (Sweden)

    Ludmyla Kandratavicius

    2012-10-01

    Full Text Available OBJECTIVE: There is accumulating evidence that the limbic system is pathologically involved in cases of psychiatric comorbidities in temporal lobe epilepsy (TLE patients. Our objective was to develop a conceptual framework describing how neuropathological, neurochemical and electrophysiological aspects might contribute to the development of psychiatric symptoms in TLE and the putative neurobiological mechanisms that cause mood disorders in this patient subgroup. METHODS: In this review, clinical, experimental and neuropathological findings, as well as neurochemical features of the limbic system were examined together to enhance our understanding of the association between TLE and psychiatric comorbidities. Finally, the value of animal models in epilepsy and mood disorders was discussed. CONCLUSIONS:TLE and psychiatric symptoms coexist more frequently than chance would predict. Alterations and neurotransmission disturbance among critical anatomical networks, and impaired or aberrant plastic changes might predispose patients with TLE to mood disorders. Clinical and experimental studies of the effects of seizures on behavior and electrophysiological patterns may offer a model of how limbic seizures increase the vulnerability of TLE patients to precipitants of psychiatric symptoms.OBJETIVO: Há evidências crescentes do envolvimento do sistema límbico nas comorbidades psiquiátricas associadas à epilepsia do lobo temporal (ELT. Nosso objetivo foi descrever o panorama atual das alterações neuropatológicas, neuroquímicas e eletrofisiológicas que podem contribuir para o desenvolvimento de sintomas psiquiátricos na ELT e explorar possíveis mecanismos neurobiológicos que podem levar ao aparecimento das desordens de humor nesse subgrupo de pacientes. MÉTODOS: Achados clínicos, de modelos experimentais e neuropatológicos foram revistos, assim como características neuroquímicas do sistema límbico foram examinadas em conjunto para auxiliar

  4. Sighting optics including an optical element having a first focal length and a second focal length

    Science.gov (United States)

    Crandall, David Lynn [Idaho Falls, ID

    2011-08-01

    One embodiment of sighting optics according to the teachings provided herein may include a front sight and a rear sight positioned in spaced-apart relation. The rear sight includes an optical element having a first focal length and a second focal length. The first focal length is selected so that it is about equal to a distance separating the optical element and the front sight and the second focal length is selected so that it is about equal to a target distance. The optical element thus brings into simultaneous focus, for a user, images of the front sight and the target.

  5. A epilepsia, o epiléptico e o trabalho: relações conflitantes Epilepsy, epileptics, and work: conflicting relations

    Directory of Open Access Journals (Sweden)

    Maria Rosa Silva Sarmento

    2000-01-01

    Full Text Available A inserção dos portadores de epilepsia no trabalho vem condicionada por um conjunto de fatores interrelacionados referentes à epilepsia, ao indivíduo epiléptico e aos códigos culturais implícitos na sociedade. A fim de analisar essa inserção conflitiva, que interfere decisivamente na qualidade de vida do epiléptico, realizou-se uma investigação com 339 pacientes do Hospital Universitário da Universidade Federal Fluminense. Aplicaram-se questionários incluindo: nível educacional, qualificação profissional, situação de emprego, freqüência e tipo de crise, duração, fenômenos associados e formas de discriminação. Constata-se que o controle das crises é fator decisivo para o ingresso e permanência no mercado de trabalho. Todos os pacientes com crises diárias e 9,3% daqueles com crises semanais nunca exerceram atividade regular remunerada. Intervir nesse quadro supõe: a implementação de programas terapêuticos multiprofissionais e intersetoriais, uma legislação que proteja os direitos do epiléptico e um amplo investimento no sentido de desmistificar a epilepsia.Participation in the workplace by people with epilepsy is conditioned by various interrelated issues concerning epilepsy itself, the epileptic individual, and society's implicit cultural codes. In order to analyze how such conflictive participation interferes decisively in the quality of life of people with epilepsy, a survey was conducted with 339 patients at the University Hospital of Universidade Federal Fluminense. Patients answered questionnaires including level of schooling, professional qualifications, employment situation, frequency, type, and duration of seizures, associated phenomena, and prejudice towards epilepsy. We observed that satisfactory management of seizures is decisive for their success at work. All patients with daily seizures and 9.3% of those with weekly seizures had never been employed. We conclude that any intervention in this context

  6. Síndrome de personalidade interictal na epilepsia do lobo temporal não-dominante: relato de caso Interictal personality syndrome in temporal lobe epilepsy: case report

    Directory of Open Access Journals (Sweden)

    PAULO C. TREVISOL-BITTENCOURT

    2000-06-01

    Full Text Available A síndrome de personalidade interictal na epilepsia do lobo temporal não-dominante consiste de hipossexualidade, hiperreligiosidade, alteração do humor e hipergrafia. Sua descrição, em 1974, foi seguida de extensa busca por estes sinais em uma vasta população de pacientes epilépticos. No entanto, estes estudos científicos fracassaram em encontrar este síndrome na epilepsia do lobo temporal em geral. Sua existência foi, por conseguinte, posta em dúvida. Apresentamos o caso de um senhor de 35 anos cuja peculiaridade hipergráfica é o desenho de plantas de construção civil em grande quantidade, além de hiperreligiosidade, hipossexualidade e circunstancialidade. É o primeiro relato deste tipo de expressão gráfica associada à epilepsia parcial complexa e esclerose mesial temporal. Dentre os mecanismos fisiopatológicos propostos, o mais coerente é o da hiperconexão temporal. Embora as crises possam ser controladas em grande parte dos casos com tratamento clínico ou cirúrgico, a sintomatologia comportamental é refratária ao tratamento psicoterápico.The syndrome of interictal personality in non-dominant temporal lobe epilepsy consists of hyposexuality, hyperreligiosity, humorlessness and hypergraphia. Its notification, in 1974, was followed by an extensive search for these traits in broad epileptic populations. Nevertheless, these statistical studies failed to match this syndrome in general temporal lobe epileptics, and its existence became then target of doubt. We report the case of a 35 year-old man presenting partial complex epilepsy, whose singularity lies in his sophisticated drawing abilities. The large amount of buildings and houses he paints expresses his hypergraphia. He also presents hyposexuality and hyperreligiosity. MRI shows right mesial temporal sclerosis. Temporal hyperconnection, caused by a basal temporal irritative focus, is the most probable pathophysiological mechanism. Epileptic fits can be controlled

  7. Papel de los fármacos antiepilépticos genéricos en el tratamiento de la epilepsia infantil Role of generic antiepileptic drugs in the treatment of childhood epilepsy

    Directory of Open Access Journals (Sweden)

    Jaime Campos-Castelló

    2009-01-01

    Full Text Available La aparición de fármacos genéricos en el mercado, en sustitución de marcas registradas®, y las adecuadas regulaciones de las autoridades sanitarias en los distintos países ha condicionado hasta la actualidad una polémica sobre el riesgo costo/beneficio de tal sustitución en el paciente afecto de epilepsia. El binomio costo/beneficio debe dar por demostrado de manera clara que el paciente puede beneficiarse de tal sustitución sin correr riesgo alguno significativo. Por ello se valoran los distintos aportes en la literatura médica al respecto, que analizan estos riesgos y beneficios y en especial el hecho esencial de la bioequivalencia de ambas formulaciones, en especial en las situaciones de aquellos fármacos antiepilépticos de margen o índice terapéutico estrecho que hagan inviable la equivalencia de la biodisponibilidad del fármaco, la ausencia de repercusión clínica real en el paciente así como la evidencia que existe un beneficio económico claro al valorar el citado binomio riesgo/beneficio. La revisión efectuada señala la clara existencia de desventajas potenciales del cambio de un fármaco antiepiléptico (FAE original de marca a un genérico como: distinta biodisponibilidad, bioequivalencia no demostrada, riesgo de reaparición de crisis en pacientes controlados y variabilidad de la respuesta de los FAE en el paciente epiléptico, imposible de predecir. Por ello se aconseja valorar la importancia de un fracaso terapéutico tras un cambio a genérico, en especial en casos de margen terapéutico estrecho, la biodisponibilidad permisible con valoración de la variabilidad individual del paciente, situación médico-legal de tal cambio y la realidad de los ahorros y costos potenciales derivados.The use of generic instead of trade mark antiepileptic drugs raises the question of cost/benefit risks. The efficacy and side effects of the generic AED should be similar to the trade mark drugs. Otherwise, the substitution is not

  8. Transparent meta-analysis: does aging spare prospective memory with focal vs. non-focal cues?

    Directory of Open Access Journals (Sweden)

    Bob Uttl

    Full Text Available BACKGROUND: Prospective memory (ProM is the ability to become aware of a previously-formed plan at the right time and place. For over twenty years, researchers have been debating whether prospective memory declines with aging or whether it is spared by aging and, most recently, whether aging spares prospective memory with focal vs. non-focal cues. Two recent meta-analyses examining these claims did not include all relevant studies and ignored prevalent ceiling effects, age confounds, and did not distinguish between prospective memory subdomains (e.g., ProM proper, vigilance, habitual ProM (see Uttl, 2008, PLoS ONE. The present meta-analysis focuses on the following questions: Does prospective memory decline with aging? Does prospective memory with focal vs. non-focal cues decline with aging? Does the size of age-related declines with focal vs. non-focal cues vary across ProM subdomains? And are age-related declines in ProM smaller than age-related declines in retrospective memory? METHODS AND FINDINGS: A meta-analysis of event-cued ProM using data visualization and modeling, robust count methods, and conventional meta-analysis techniques revealed that first, the size of age-related declines in ProM with both focal and non-focal cues are large. Second, age-related declines in ProM with focal cues are larger in ProM proper and smaller in vigilance. Third, age-related declines in ProM proper with focal cues are as large as age-related declines in recall measures of retrospective memory. CONCLUSIONS: The results are consistent with Craik's (1983 proposal that age-related declines on ProM tasks are generally large, support the distinction between ProM proper vs. vigilance, and directly contradict widespread claims that ProM, with or without focal cues, is spared by aging.

  9. Focal thyroid inferno” on color Doppler ultrasonography: A specific feature of focal Hashimoto's thyroiditis

    International Nuclear Information System (INIS)

    Fu, Xianshui; Guo, Limei; Zhang, Huabin; Ran, Weiqiang; Fu, Peng; Li, Zhiqiang; Chen, Wen; Jiang, Ling; Wang, Jinrui; Jia, Jianwen

    2012-01-01

    Purpose: To evaluate color-Doppler features predictive of focal Hashimoto's thyroiditis. Materials and methods: A total of 521 patients with 561 thyroid nodules that underwent surgeries or gun biopsies were included in this study. These nodules were divided into three groups: focal Hashimoto's thyroiditis (104 nodules in 101 patients), benignity other than focal Hashimoto's thyroiditis (73 nodules in 70 patients), and malignancy (358 nodules in 350 patients). On color Doppler sonography, four vascularity types were determined as: hypovascularity, marked internal flow, marked peripheral flow and focal thyroid inferno. The χ 2 test was performed to seek the potential vascularity type with the predictive ability of certain thyroid pathology. Furthermore, the gray-scale features of each nodule were also studied. Results: The vascularity type I (hypovascularity) was more often seen in focal Hashimoto's thyroiditis than other benignity and malignancy (46% vs. 20.5% and 19%). While the type II (marked internal flow) showed the opposite tendency (26.9% [focal Hashimoto's thyroiditis] vs. 45.2% [other benignity] and 52.8% [malignancy]). However, type III (marked peripheral flow) was unable to predict any thyroid pathology. Importantly, type IV (focal thyroid inferno) was exclusive to focal Hashimoto's thyroiditis. All 8 type IV nodules appeared to be solid, hypoechoic, and well-defined. Using “focal thyroid inferno” as an indicator of FHT, the diagnostic sensitivity and specificity were 7.7% and 100% respectively. Conclusions: The vascularity type of “focal thyroid inferno” is specific for focal Hashimoto thyroiditis. Recognition of this particular feature may avoid unnecessary interventional procedures for some solid hypoechoic thyroid nodules suspicious of malignancy.

  10. Prenatal sonographic diagnosis of focal musculoskeletal anomalies

    International Nuclear Information System (INIS)

    Ryu, Jung-Kyu; Cho, Jeong-Yeon; Choi, Jong-Sun

    2003-01-01

    Focal musculoskeletal anomalies vary, and can manifest as part of a syndrome or be accompanied by numerous other conditions such as genetic disorders, karyotype abnormalities, central nervous system anomalies and other skeletal anomalies, lsolated focal musculoskeletal anomaly does, however, also occur; its early prenatal diagnosis is important in deciding prenatal care, and also helps in counseling parents about the postnatal effects of numerous possible associated anomalies. We have encountered 50 cases involving focal musculoskeletal anomalies, including total limb dysplasia [radial ray abnormality (n=3), mesomelic dysplasia (n=1)]; anomalies of the hand [polydactyly (n=8), syndactyly (n=3), ectrodactyly (n=1), clinodactyly (n=6), clenched hand (n=5)]; anomalies of the foot [clubfoot (n=10), rockerbottom foot (n=5), sandal gap deformity (n=1), curly toe (n=2)]; amniotic band syndrome (n=3); and anomalies of the focal spine [block vertebra (n=1), hemivertebra (n=1)]. Among these 50 cases, five [polydactyly (n=1), syndactyly (n=2) and curly toe (n=2) were confirmed by postnatal physical evaluation, two (focal spine anomalies) were diagnosed after postnatal radiologic examination, and the remaining 43 were proven at autopsy. For each condition, we describe the prenatal sonographic findings, and include a brief review

  11. Prenatal sonographic diagnosis of focal musculoskeletal anomalies

    Energy Technology Data Exchange (ETDEWEB)

    Ryu, Jung-Kyu; Cho, Jeong-Yeon; Choi, Jong-Sun [Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2003-12-15

    Focal musculoskeletal anomalies vary, and can manifest as part of a syndrome or be accompanied by numerous other conditions such as genetic disorders, karyotype abnormalities, central nervous system anomalies and other skeletal anomalies, lsolated focal musculoskeletal anomaly does, however, also occur; its early prenatal diagnosis is important in deciding prenatal care, and also helps in counseling parents about the postnatal effects of numerous possible associated anomalies. We have encountered 50 cases involving focal musculoskeletal anomalies, including total limb dysplasia [radial ray abnormality (n=3), mesomelic dysplasia (n=1)]; anomalies of the hand [polydactyly (n=8), syndactyly (n=3), ectrodactyly (n=1), clinodactyly (n=6), clenched hand (n=5)]; anomalies of the foot [clubfoot (n=10), rockerbottom foot (n=5), sandal gap deformity (n=1), curly toe (n=2)]; amniotic band syndrome (n=3); and anomalies of the focal spine [block vertebra (n=1), hemivertebra (n=1)]. Among these 50 cases, five [polydactyly (n=1), syndactyly (n=2) and curly toe (n=2) were confirmed by postnatal physical evaluation, two (focal spine anomalies) were diagnosed after postnatal radiologic examination, and the remaining 43 were proven at autopsy. For each condition, we describe the prenatal sonographic findings, and include a brief review.

  12. Epilepsy and sudden unexpected death in epilepsy?: Eat more fish! A group hypothesis Epilepsia e morte súbita?: Coma mais peixe! A hipótese de um grupo

    Directory of Open Access Journals (Sweden)

    Roberta M. Cysneiros

    2009-09-01

    Full Text Available Epilepsy is the commonest serious neurological disorder and individuals with epilepsy are at higher risk of death than the general population and sudden unexpected death in epilepsy (SUDEP is the most important direct epilepsy-related cause of death. Potential pathomechanisms for SUDEP are unknown, but it is very probable that cardiac arrhythmias during and between seizures play a potential role. The ultimate goal of SUDEP research is to develop methods to prevent it and nutritional aspects such as omega-3 fatty acid deficiency may have an interesting role in this scenario. Omega-3 fatty acids reduce the risk of cardiovascular mortality and are important for treating or preventing some neurological diseases, including epilepsy. A dietary modification or nutritional supplements increasing the ingestion of omega-3 fatty acids may help to ''save the brain".A epilepsia é uma das doenças neurológicas sérias mais comuns e está associada a um maior risco de morte do que o observado na população geral e a morte súbita em epilepsia é uma importante causa de morte relacionada à epilepsia. Os potenciais patomecanismos da morte súbita em epilepsia são desconhecidos, mas é bastante provável que arritmias cardíacas durante ou entre as crises tenham um papel preponderante. O objetivo final das pesquisas em morte súbita em epilepsia é o desenvolvimento de métodos que levem à sua prevenção e aspectos nutricionais, como a deficiência de ômega-3 pode ter um papel interessante neste contexto. A suplementação com ômega-3 reduz o risco de mortalidade de origem cardiovascular e é importante no tratamento e prevenção de algumas doenças neurológicas, incluindo a epilepsia. A modificação dietética ou a suplementação nutricional aumentando a ingesta de ômega-3 pode ajudar a "salvar o cérebro".

  13. Seven tesla MRI improves detection of focal cortical dysplasia in patients with refractory focal epilepsy

    NARCIS (Netherlands)

    Veersema, Tim J; Ferrier, Cyrille H; van Eijsden, Pieter; Gosselaar, Peter H; Aronica, Eleonora; Visser, Fredy; Zwanenburg, Jaco M; de Kort, Gerard A P; Hendrikse, Jeroen; Luijten, Peter R; Braun, Kees P J

    Objective: The aim of this study is to determine whether the use of 7 tesla (T) MRI in clinical practice leads to higher detection rates of focal cortical dysplasias in possible candidates for epilepsy surgery. Methods: In our center patients are referred for 7 T MRI if lesional focal epilepsy is

  14. Análise da assimetria funcional hemisférica de crianças com epilepsia parcial e QI normal pelo desempenho nos subtestes do WISC

    OpenAIRE

    Muszkat,Mauro; Vincenzo,Neyde Santacchi de; Masuko,Alice; Reami,Denilce O.; Campos,Carlos J. Reis de

    1991-01-01

    Foram avaliadas 26 crianças, sem deficiência mental, com média de idade de 9±2 anos, com epilepsia parcial sem lesão cerebral evidenciável à TCC e com atividade paroxistica no EEG intercrítico localizada apenas em um hemisfério cerebral. Essas crianças foram submetidas à Escala de Inteligência Wechsler para Crianças (WISC) e à análise dos vários subtestes verbais e execução em relação à localização hemisférica da descarga no EEG. Os dados foram comparados ao desempenho no WISC de um grupo de ...

  15. Epilepsia do lobo frontal na infância: aspectos psicológicos e neuropsicológicos = Frontal lobe epilepsy in childhood: Psychological and neuropsychological aspects

    Directory of Open Access Journals (Sweden)

    SchlindweinZanini, Rachel

    2007-01-01

    Conclusões: Na criança, a epilepsia do lobo frontal pode gerar distúrbios psicológicos e neuropsicológicos, como déficits em funções executivas (cognição, planejamento, linguagem, memória e atenção, alterações comportamentais (controle de impulsos e agressividade, manifestações de crises epilépticas comportamentais e piora da qualidade de vida. Suas alterações podem ser confundidas com doenças psiquiátricas, reforçando a importância do diagnóstico diferencial e da avaliação neuropsicológica.

  16. Expansive focal cemento-osseous dysplasia.

    Science.gov (United States)

    Bulut, Emel Uzun; Acikgoz, Aydan; Ozan, Bora; Zengin, Ayse Zeynep; Gunhan, Omer

    2012-01-01

    To present a case of expansive focal cemento-osseous dysplasia and emphasize the importance of differential diagnosis. Cemento-osseous dysplasia is categorized into three subtypes on the basis of the clinical and radiographic features: Periapical, focal and florid. The focal type exhibits a single site of involvement in any tooth-bearing or edentulous area of the jaws. These lesions are usually asymptomatic; therefore, they are frequently diagnosed incidentally during routine radiographic examinations. Lesions are usually benign, show limited growth, and do not require further surgical intervention, but periodic follow-up is recommended because occasionally, this type of dysplasia progresses into florid osseous dysplasia and simple bone cysts are formed. A 24-year-old female patient was referred to our clinic for swelling in the left edentulous mandibular premolarmolar region and felt discomfort when she wore her prosthetics. She had no pain, tenderness or paresthesia. Clinical examination showed that the swelling in the posterior mandible that was firm, nonfluctuant and covered by normal mucosa. On panoramic radiography and computed tomography, a well defined lesion of approximately 1.5 cm in diameter of mixed density was observed. The swelling increased slightly in size over 2 years making it difficult to use prosthetics and, therefore, the lesion was totally excised under local anesthesia, and surgical specimens were submitted for histopathological examination. The histopathological diagnosis was focal cemento-osseous dysplasia. In the present case, because of the increasing size of the swelling making it difficult to use prosthetics, young age of the patient and localization of the lesion, in the initial examination, cemento-ossifying fibroma was suspected, and the lesion was excised surgically; the histopathological diagnosis confirmed it as focal cemento-osseous dysplasia. We present a case of expansive focal cemento-osseous dysplasia. Differential diagnosis

  17. Inseguridad alimentaria en latinos de California: observaciones de grupos focales

    Directory of Open Access Journals (Sweden)

    Melgar-Quiñonez Hugo

    2003-01-01

    Full Text Available OBJETIVO: Estudiar la percepción y la experiencia sobre inseguridad alimentaria entre latinoamericanos de California, así como su interpretación de los insumos incluidos en la Escala de Seguridad Alimentaria. MATERIAL Y MÉTODOS: Entre noviembre y diciembre de 2000, en los condados californianos de Solano y San Joaquín, se efectuaron cuatro grupos focales, con 30 adultos de origen latinoamericano residentes allí. Los comentarios de los participantes fueron codificados por dos investigadores para determinar los temas principales, y fueron confrontados para verificar su convergencia. RESULTADOS: Las preguntas fueron bien comprendidas, no percibiéndose como ofensivas. El marco conceptual se confirmó como "proceso manejado" con diferentes niveles de severidad. Las causas de inseguridad alimentaria identificadas fueron: desempleo, alto costo de algunos alimentos y falta de información nutricional. La necesidad de educación nutricional fue una constante. CONCLUSIONES: Para interpretar datos nacionales de inseguridad alimentaria en latinoamericanos es esencial considerar su percepción particular de ese fenómeno.

  18. Extensive Focal Epithelial Hyperplasia: A Case Report.

    Science.gov (United States)

    Mansouri, Zahra; Bakhtiari, Sedigheh; Noormohamadi, Robab

    2015-01-01

    Focal epithelial hyperplasia (FEH) or Heck's disease is a rare viral infection of the oral mucosa caused by human papilloma virus especially subtypes 13 or 32. The frequency of this disease varies widely from one geographic region and ethnic groups to another. This paper reports an Iranian case of extensive focal epithelial hyperplasia. A 35-year-old man with FEH is described, in whom the lesions had persisted for more than 25 years. The lesion was diagnosed according to both clinical and histopathological features. Dental practitioner should be aware of these types of lesions and histopathological examination together and a careful clinical observation should be carried out for a definitive diagnosis.

  19. Actinic Granuloma with Focal Segmental Glomerulosclerosis

    Directory of Open Access Journals (Sweden)

    Ruedee Phasukthaworn

    2016-02-01

    Full Text Available Actinic granuloma is an uncommon granulomatous disease, characterized by annular erythematous plaque with central clearing predominately located on sun-damaged skin. The pathogenesis is not well understood, ultraviolet radiation is recognized as precipitating factor. We report a case of a 52-year-old woman who presented with asymptomatic annular erythematous plaques on the forehead and both cheeks persisting for 2 years. The clinical presentation and histopathologic findings support the diagnosis of actinic granuloma. During that period of time, she also developed focal segmental glomerulosclerosis. The association between actinic granuloma and focal segmental glomerulosclerosis needs to be clarified by further studies.

  20. Focal splenic masses of the extramedullary hematopoiesis

    International Nuclear Information System (INIS)

    Incedayi, M.; Sivrioglu, A.

    2012-01-01

    Full text: Extramedullary hematopoiesis arises from pleuripotential stem cells distributed throughout the body. It is most common in patients with congenital hemolytic anemia, such as thalassemia, sickle cell anemia and hereditary spherocytosis as a response to ineffective red blood cell formation. Although microscopic foci of Extramedullary hematopoiesis are commonly seen in the spleen and liver parenchyma, focal mass-like lesion of extramedullary hematopoiesis in the liver and spleen are rare. We report a case of intrasplenic focal extramedullary hematopoiesis lesions and the imaging features of extramedullary hematopoiesis on computed tomography and magnetic resonance imaging. Extramedullary hematopoiesis should always be considered as a diagnosis in a patient with a known hematological disorder

  1. DISTURBIOS PRAXICOS EN LESIONES FOCALES DE LOS HEMISFERIOS CEREBRALES

    Directory of Open Access Journals (Sweden)

    Jorge Murillo Duran

    2007-01-01

    Full Text Available El propósito de este trabajo es analizar la dificultad paraxial, es decir, los desórdenes funcionales en el movimiento resultado de lesiones cerebrales del tejido fino. De acuerdo con la literatura sobre la materia, se ha aceptado la definición de la apraxia como la inhabilidad en ejecutar correctamente tareas cinéticas, sin la debilitación o la pérdida de motricidad o de funciones sensoriales o la ataxia como condicionante de tal inhabilidad". La "ejecución apropiada" utilizada en esta definición considera no solamente el efecto de la acción, también los medios de su realización. Las "tareas cinéticas" significan todos los aspectos de la actividad motora definidos por las instrucciones, independientes del tipo de instrucción (verbal o los gestos, y sin importar si lograron el efecto final imitando el movimiento del investigador o si fueron realizadas independientemente. La metodología se ha basado en principio en los trabajos de A.R.Luria.. Las discusiones fueron basadas en los resultados de la investigación que comprendían a 90 pacientes con lesiones cerebrales focales. En cincuenta casos, los cambios fueron localizados en el hemisferio cerebral izquierdo, en cuarenta casos en el hemisferio derecho. Los resultados alcanzaron permiten formar la opinión que no todas las pruebas generalmente aceptadas que investigan praxia en personas con lesiones cerebrales son solucionadas favorablemente por individuos sanos; así, una ejecución deficiente no se debe mirar siempre como muestra del funcionamiento patológico del tejido fino cerebral como resultado de la lesión.

  2. Infrared MUSIC from Z technology focal planes

    International Nuclear Information System (INIS)

    Waters, C.R.; Sommese, A.; Johnston, D.; Landau, H.

    1989-01-01

    Presented is the Multiple Signal Classification (MUSIC) algorithm which uses the high frequency differences in sensed time signals to discriminate, count, and accurately locate closely spaced targets. Z technology focal planes allow the implementation of this algorithm and the trade-off between finer spatial resolution systems and systems with coarser resolution but higher sampling rates

  3. Focal dermal hypoplasia: A rare case report

    Directory of Open Access Journals (Sweden)

    Sahana M Srinivas

    2015-01-01

    Full Text Available Focal dermal hypoplasia (Goltz syndrome is a rare genetic multisystem disorder primarily involving the skin, skeletal system, eyes, and face. We report the case of an eight-month-old female child who presented with multiple hypopigmented atrophic macules along the lines of blaschko, skeletal anomalies, umbilical hernia, developmental delay, hypoplastic nails, syndactyly, and lobster claw deformity characteristic of Goltz syndrome.

  4. Riso na epilepsia

    Directory of Open Access Journals (Sweden)

    Edymar Jardim

    1967-06-01

    Full Text Available São estudados três casos de síndrome convulsiva temporal, com manifestações concomitantes de riso na sua fase inicial. As características principais foram a imotivação e á incoercibilidade do riso. Esses sintomas desapareceram com o uso de anticonvulsivantes.

  5. DESI focal plate mechanical integration and cooling

    Science.gov (United States)

    Lambert, A. R.; Besuner, R. W.; Claybaugh, T. M.; Silber, J. H.

    2016-08-01

    The Dark Energy Spectroscopic Instrument (DESI) is under construction to measure the expansion history of the Universe using the Baryon Acoustic Oscillation technique[1]. The spectra of 40 million galaxies over 14000 sq. deg will be measured during the life of the experiment. A new prime focus corrector for the KPNO Mayall telescope will deliver light to 5000 fiber optic positioners. The fibers in turn feed ten broad-band spectrographs. This paper describes the mechanical integration of the DESI focal plate and the thermal system design. The DESI focal plate is comprised of ten identical petal assemblies. Each petal contains 500 robotic fiber positioners. Each petal is a complete, self-contained unit, independent from the others, with integrated power supply, controllers, fiber routing, and cooling services. The major advantages of this scheme are: (1) supports installation and removal of complete petal assemblies in-situ, without disturbing the others, (2) component production, assembly stations, and test procedures are repeated and parallelizable, (3) a complete, full-scale prototype can be built and tested at an early date, (4) each production petal can be surveyed and tested as a complete unit, prior to integration, from the fiber tip at the focal surface to the fiber slit at the spectrograph. The ten petal assemblies will be installed in a single integration ring, which is mounted to the DESI corrector. The aluminum integration ring attaches to the steel corrector barrel via a flexured steel adapter, isolating the focal plate from differential thermal expansions. The plate scale will be kept stable by conductive cooling of the petal assembly. The guider and wavefront sensors (one per petal) will be convectively cooled by forced flow of air. Heat will be removed from the system at ten liquid-cooled cold plates, one per petal, operating at ambient temperature. The entire focal plate structure is enclosed in an insulating shroud, which serves as a thermal barrier

  6. Physical exercise in rats with epilepsy is protective against seizures: evidence of animal studies Exercício físico em ratos com epilepsia como fator protetor contra crises epilépticas: evidencias de estudos em animais

    Directory of Open Access Journals (Sweden)

    Ricardo Mario Arida

    2009-12-01

    Full Text Available People with epilepsy have been discouraged from participating in physical activity due to the fear that it will exacerbate seizures. Clinical and animal studies indicate a reduction of seizure frequency as well as decrease susceptibility to subsequently evoked seizures after an exercise program. Analyses from experimental studies of animals with epilepsy submitted to physical training programs were performed. In all studies the physical training was able to reduce the number of spontaneous seizures in rats with epilepsy. Seizure occurrence during exercise was relatively absent in the majority of studies. No death was found in animals with epilepsy during 1680 h of exercise. Based on these results it is plausible encouraging persons with epilepsy to non-pharmacological treatments and preventative measures such as physical exercise.Pessoas com epilepsia têm sido desencorajadas da prática de atividade física por receio do exercício físico exacerbar as crises epilépticas. Estudos clínicos e em animais mostram uma redução da frequência de crises, assim como diminuição da susceptibilidade a crises subseqüentes após programa de exercício físico. Neste estudo realizamos uma análise de estudos experimentais de animais com epilepsia submetidos a programas de exercício físico. Em todos os estudos, o treinamento físico foi capaz de reduzir o número de crises espontâneas em ratos com epilepsia. A ocorrência de crises durante o exercício físico foi relativamente ausente na maioria dos estudos. Nenhuma morte foi encontrada em animais com epilepsia durante 1680 h de exercício físico. Baseados nestes resultados parece aceitável encorajar as pessoas com epilepsia a tratamentos não farmacológicos e medidas preventivas como o exercício físico.

  7. Radiopneumographic characteristics of focal pneumonia in children

    International Nuclear Information System (INIS)

    Smirnova, A.A.

    1980-01-01

    Zonal ventilation and blood flow were studied by the radiopneumography method in 50 children of school age with lower-lobe-of-the lung focal pneumonia (26 with left-side and 24 with right-side). It is established that during right-side localization of pneumonic focus preserved was the predomination of ventilation of right lung relative to left. Complete normalization of common and regional indexes of ventilation and blood flow was established by the 21st day from the beginning of treatment during right-side focal pneumonias. In case of left-side localization of pneumonic focus only partial reduction of external respiration and perfusion comes. Therefore, compensatory and reducing capabilities of right lung are preferrable

  8. Membership Functions for Fuzzy Focal Elements

    Directory of Open Access Journals (Sweden)

    Porębski Sebastian

    2016-09-01

    Full Text Available The paper presents a study on data-driven diagnostic rules, which are easy to interpret by human experts. To this end, the Dempster-Shafer theory extended for fuzzy focal elements is used. Premises of the rules (fuzzy focal elements are provided by membership functions which shapes are changing according to input symptoms. The main aim of the present study is to evaluate common membership function shapes and to introduce a rule elimination algorithm. Proposed methods are first illustrated with the popular Iris data set. Next experiments with five medical benchmark databases are performed. Results of the experiments show that various membership function shapes provide different inference efficiency but the extracted rule sets are close to each other. Thus indications for determining rules with possible heuristic interpretation can be formulated.

  9. Focal epilepsy in the Belgian shepherd

    DEFF Research Database (Denmark)

    Berendt, Mette; Gulløv, Christina Hedal; Fredholm, Merete

    2009-01-01

    and deceased) were ascertained through a telephone interview using a standardised questionnaire regarding seizure history and phenomenology. Living dogs were invited to a detailed clinical evaluation. Litters more than five years of age, or where epilepsy was present in all offspring before the age of five......, were included in the calculations of inheritance. results: Out of 199 family members, 66 dogs suffered from epilepsy. The prevalence of epilepsy in the family was 33%. Fifty-five dogs experienced focal seizures with or without secondary generalisation, while four dogs experienced primary generalised...... seizures. In seven dogs, seizures could not be classified. The mode of inheritance of epilepsy was simple Mendelian. CLINICAL SIGNIFICANCE: This study identified that the Belgian shepherd suffers from genetically transmitted focal epilepsy. The seizure phenomenology expressed by family members have...

  10. Chest pain in focal musculoskeletal disorders

    DEFF Research Database (Denmark)

    Stochkendahl, Mette Jensen; Christensen, Henrik Wulff

    2010-01-01

    overlapping conditions and syndromes of focal disorders, including Tietze syndrome, costochondritis, chest wall syndrome, muscle tenderness, slipping rib, cervical angina, and segmental dysfunction of the cervical and thoracic spine, have been reported to cause pain. For most of these syndromes, evidence......The musculoskeletal system is a recognized source of chest pain. However, despite the apparently benign origin, patients with musculoskeletal chest pain remain under-diagnosed, untreated, and potentially continuously disabled in terms of anxiety, depression, and activities of daily living. Several...... arises mainly from case stories and empiric knowledge. For segmental dysfunction, clinical features of musculoskeletal chest pain have been characterized in a few clinical trials. This article summarizes the most commonly encountered syndromes of focal musculoskeletal disorders in clinical practice....

  11. Characterization of LIL laser UV focal spot

    International Nuclear Information System (INIS)

    Mangeant, M.; Dubois, J.L.; Behar, G.; Arroyo, P.; Durand, V.; Lahonde, C.

    2006-01-01

    One way to get the fusion of hydrogen in laboratory consists in heating and compressing a DT fuel capsule by using a laser. To reach this aim requires a new generation of high power laser facility. Cea (French board for atomic energy) is developing for this purpose a new 240 laser line facility, the LMJ facility. The LIL which is the prototype of four LMJ laser lines is operational now. In order to confirm the technical choices, a systematic characterization of LIL was carried out. A particular effort has been provided to measure the 3ω high energy focal spot (1.5 kJ/700 ps and 5 ns for one beam) and the synchronization of laser beams onto the target, which are key issues for the plasma production. An experimental device, SAT-3ω (a 3ω laser focal spot analysis) has been designed to perform these measures. That diagnostic which is located at the end of the laser lines delivered its first results during the 2004 quadruplet qualification campaigns. The near field imaging showed no diaphony and vignetting. Low power spots allowed us to control we had no ghost. The energy measurement quality showed the photometric transfer function was perfectly known. Our caustic image are given with an average dynamic range of 800, a spatial resolution of 10 μm and diameter accuracy about 1% for 50% and 3% for 90% of encircled energy. The high energy focal spot diameters are in agreement with low and very low energy diameters. The phase plate and 14 GHz effects are similar to what we had expected. For a laser shot completed with a continuous phase plate at 14 GHz, and for an energy level of 1.5 kJ per beam at 351 nm, the focal beam diameter at 3% of the peak level is (875 ± 45) μm

  12. Proximal focal femoral deficiency: A case report

    Directory of Open Access Journals (Sweden)

    Shashank Sharma

    2015-01-01

    Full Text Available Proximal focal femoral deficiency (PFFD is a rare congenital anomaly resulting in limb shortening and disability in young. The exact cause of the disease is not known and it may present as varying grades of affection involving the proximal femur and the acetabulum. Recognition of this rare abnormality on radiographs can help manage these cases better since early institution of therapy may help in achieving adequate growth of the femur.

  13. Syndecan-4 and focal adhesion function

    DEFF Research Database (Denmark)

    Woods, A; Couchman, J R

    2001-01-01

    Two groups have now reported the viability of mice that lack syndecan-4. These mice have wound healing/angiogenesis problems, and fibroblasts from these animals differ in adhesion and migration from normal. This is consistent with recent in vitro data indicating a need for signaling via syndecan-4...... for focal adhesion formation, and reports that overexpression of proteins that bind syndecan-4 can modify cell adhesion and migration....

  14. Carbamazepine does not alter the intrinsic cardiac function in rats with epilepsy Carbamazepina não altera o funcionamento cardíaco intrínseco em ratos com epilepsia

    Directory of Open Access Journals (Sweden)

    Diego B Colugnati

    2010-08-01

    Full Text Available Among the causes for sudden unexpected death (SUDEP in epilepsy, the effects of antiepileptic drugs on the heart have been poorly explored. Based on this, the aim of our study was to evaluate the heart rate (in vivo and isolated ex vivo and ventricular pressure (isolated ex vivo of rats with and without epilepsy treated with carbamazepine. Four groups of adult, male Wistar rats (200-250 g were studied: [A] control rats (n=8, received neither pilocarpine nor carbamazepine [B] carbamazepine-treated rats (n=8, received a daily dose of 120 mg/Kg, i.p. of carbamazepine for two weeks; [C] rats with epilepsy that received just saline solution (n=8; [D] rats with epilepsy that received a daily dose of 120 mg/Kg, i.p. of carbamazepine for two weeks (n=8. Our results showed significant increase in heart rate in animals with epilepsy (with and without the use of carbamazepine when compared to the control groups in vivo. In contrast, we did not find differences during isolated ex vivo experiments comparing animals with and without epilepsy and despite the use of carbamazepine. Our results suggest that, in isolation, carbamazepine may not be a potential risk factor for sudden unexpected death in epilepsy.Entre as causas de morte súbita em epilepsia (SUDEPE, os efeitos das drogas antiepilépticas no coração têm sido pobremente explorados. Desta forma, o objetivo deste estudo foi avaliar a frequência cardíaca (in vivo e de forma isolada ex vivo e a pressão ventricular (de forma isolada ex vivo de ratos com e sem epilepsia tratados com carbamazepina. Quatro grupos de ratos Wistar machos adultos (peso 200 a 250 g foram estudados: [A] ratos controle (n=8, não receberam pilocarpina ou carbamazepina; [B] ratos tratados com carbamazepina (n=8, receberam dose diária de carbamazepina de 120 mg/kg intraperitoneal, durante duas semanas (n=8; [C] ratos com epilepsia que receberam solução salina; [D] ratos com epilepsia que receberam dose diária de

  15. Coincidence scanning with positron-emitting arsenic or copper in the diagnosis of focal intracranial disease; Exploration par coincidences avec l'Arsenic ou le Cuivre Emetteurs de Positrons dans le Diagnostic des Maladies intracraniennes localisees; Raspoznavanie ochagovykh vnutricherepnykh zabolevanij putem podscheta (skanirovaniya) sovpralenij s primeneniem mysh'yaka ili medi, vydelyayushchikh pozitrony; Exploracion por coincidencia con arsenico o cobre emisores de positrones en el diagnostico de enfermedades intracraneanas localizadas

    Energy Technology Data Exchange (ETDEWEB)

    Sweet, William H; Mealey, John Jr; Brownell, Gordon L; Aronow, Saul [Departments of Surgery and Medicine, Harvard Medical School, and Neurosurgical Service and Physics Research Laboratory of Massachusetts General Hospital, Boston, MA (United States)

    1959-07-01

    of the asymmetry of the total gamma radiation, an asymmetrogammagra m (AGG). A sagittal PCG is also taken. The lateral scan requires 40 minutes, the sagittal 20 minutes. Of the more than 3000 scans carried out we report here only the 285 performed in the last 3 1/2 years on a special group of 334 patients, who nearly all proved to have focal, usually space-taking, lesions and on whom we have a gross anatomical and histological diagnosis established after surgery or autopsy. In this group a correct diagnosis was made in 80 per cent of 249 tumors scanned with arsenic and in 70 per cent of 84 tumors scanned with copper. In a previous series of 207 arsenic scans in a similar group we localized only 69 per cent of the tumors. In the current series only 3 of 83 glioblastomas, and 3 of 34 meningiomas were missed with arsenic. At least one tumor was localized with arsenic in 85 per cent of those with one or more malignant metastases. The results with copper were not quite as good in any of these 3 major categories. Of the 182 tumors of one or both cerebral hemispheres studied with arsenic the correct diagnosis was made in 165, or 91 per cent; with copper there was 81 per cent success with 64 patients of this type. Since it is especially the small cerebral tumors which are likely to be missed by angiography or pneumography at a time when they are surgically resectable, this is perhaps the most important contribution of the method to date. In contrast we did poorly with subtentorial tumors, missing 23 of 39 or 59 per cent. In the non-neoplastic group we localized 7 of 8 subdural hematomas with arsenic; one of 3 with copper. Verified intracerebral clots were spotted in 4 of 5 cases with arsenic and in 1 of 3 with copper. All 10 abscesses were found with arsenic and 3 of 4 with copper. In all 3 patients with leukoencephalopath y the arsenic scans indicated the major areas of demyelination. Of 10 patients who had had a total of 16 scans and who were subjected to craniotomy with a

  16. Focal adhesions, stress fibers and mechanical tension

    Energy Technology Data Exchange (ETDEWEB)

    Burridge, Keith, E-mail: Keith_Burridge@med.unc.edu [Department of Cell Biology and Physiology, and Lineberger Comprehensive Cancer Center, 12-016 Lineberger, CB#7295, University of North Carolina, Chapel Hill, NC (United States); Guilluy, Christophe, E-mail: christophe.guilluy@univ-nantes.fr [Inserm UMR-S1087, CNRS UMR-C6291, L' institut du Thorax, and Université de Nantes, Nantes (France)

    2016-04-10

    Stress fibers and focal adhesions are complex protein arrays that produce, transmit and sense mechanical tension. Evidence accumulated over many years led to the conclusion that mechanical tension generated within stress fibers contributes to the assembly of both stress fibers themselves and their associated focal adhesions. However, several lines of evidence have recently been presented against this model. Here we discuss the evidence for and against the role of mechanical tension in driving the assembly of these structures. We also consider how their assembly is influenced by the rigidity of the substratum to which cells are adhering. Finally, we discuss the recently identified connections between stress fibers and the nucleus, and the roles that these may play, both in cell migration and regulating nuclear function. - Highlights: • The different types of stress fiber and focal adhesion are described. • We discuss the controversy about tension and assembly of these structures. • We describe the different models used to investigate assembly of these structures. • The influence of substratum rigidity is discussed. • Stress fiber connections to the nucleus are reviewed.

  17. Focal plane scanner with reciprocating spatial window

    Science.gov (United States)

    Mao, Chengye (Inventor)

    2000-01-01

    A focal plane scanner having a front objective lens, a spatial window for selectively passing a portion of the image therethrough, and a CCD array for receiving the passed portion of the image. All embodiments have a common feature whereby the spatial window and CCD array are mounted for simultaneous relative reciprocating movement with respect to the front objective lens, and the spatial window is mounted within the focal plane of the front objective. In a first embodiment, the spatial window is a slit and the CCD array is one-dimensional, and successive rows of the image in the focal plane of the front objective lens are passed to the CCD array by an image relay lens interposed between the slit and the CCD array. In a second embodiment, the spatial window is a slit, the CCD array is two-dimensional, and a prism-grating-prism optical spectrometer is interposed between the slit and the CCD array so as to cause the scanned row to be split into a plurality of spectral separations onto the CCD array. In a third embodiment, the CCD array is two-dimensional and the spatial window is a rectangular linear variable filter (LVF) window, so as to cause the scanned rows impinging on the LVF to be bandpass filtered into spectral components onto the CCD array through an image relay lens interposed between the LVF and the CCD array.

  18. Classification of Focal and Non Focal Epileptic Seizures Using Multi-Features and SVM Classifier.

    Science.gov (United States)

    Sriraam, N; Raghu, S

    2017-09-02

    Identifying epileptogenic zones prior to surgery is an essential and crucial step in treating patients having pharmacoresistant focal epilepsy. Electroencephalogram (EEG) is a significant measurement benchmark to assess patients suffering from epilepsy. This paper investigates the application of multi-features derived from different domains to recognize the focal and non focal epileptic seizures obtained from pharmacoresistant focal epilepsy patients from Bern Barcelona database. From the dataset, five different classification tasks were formed. Total 26 features were extracted from focal and non focal EEG. Significant features were selected using Wilcoxon rank sum test by setting p-value (p z > 1.96) at 95% significance interval. Hypothesis was made that the effect of removing outliers improves the classification accuracy. Turkey's range test was adopted for pruning outliers from feature set. Finally, 21 features were classified using optimized support vector machine (SVM) classifier with 10-fold cross validation. Bayesian optimization technique was adopted to minimize the cross-validation loss. From the simulation results, it was inferred that the highest sensitivity, specificity, and classification accuracy of 94.56%, 89.74%, and 92.15% achieved respectively and found to be better than the state-of-the-art approaches. Further, it was observed that the classification accuracy improved from 80.2% with outliers to 92.15% without outliers. The classifier performance metrics ensures the suitability of the proposed multi-features with optimized SVM classifier. It can be concluded that the proposed approach can be applied for recognition of focal EEG signals to localize epileptogenic zones.

  19. Multispectral linear array (MLA) focal plane mechanical and thermal design

    Science.gov (United States)

    Mitchell, A. S.; Kaminski, E. F.

    1982-01-01

    The mechanical and thermal design of an integrated focal plane subsystem of a Multispectral Linear Array (MLA) instrument is discussed in terms of focal-plane alignment, thermoelastic performance, and thermal requirements. The modular construction and thermal control of the focal plane array are discussed.

  20. Prevalence of epilepsy in a case series of multiple sclerosis patients Prevalência de epilepsia numa coorte de pacientes com esclerose múltipla

    Directory of Open Access Journals (Sweden)

    Cynthia Dumas Viveiros

    2010-10-01

    Full Text Available OBJECTIVE: The prevalence of epilepsy in multiple sclerosis (MS patients has been a subject of interest for some years. The objectives of this study were to describe the clinical, radiological and electroencephalographic characteristics of epileptic seizures and to calculate the prevalence of epilepsy in a case series of MS patients. METHOD: Medical charts of MS patients were reviewed and patients who had suffered epileptic seizures were identified. RESULTS: Of 160 cases analyzed, 5 had suffered epileptic seizures and one had comorbid mesial hippocampal sclerosis, confirmed by magnetic resonance imaging in a patient with complex partial seizures that began fifteen years prior to her diagnosis of MS. In the other four patients, seizures occurred both during the acute phase of the disease and in the chronic phase. CONCLUSION: The prevalence of epileptic seizures in MS patients in this study was 2.5%, similar to that found in other studies.OBJETIVO: A prevalência da epilepsia em pacientes com esclerose múltipla (EM tem sido objeto de interesse há vários anos. Os objetivos deste estudo foram descrever as características clínicas, radiológicas e eletroencefalográficas das crises epilépticas e estimar a prevalência de epilepsia na EM numa série de casos. MÉTODO: Foram revisados prontuários de pacientes com EM e identificados os casos que apresentaram crise epiléptica. RESULTADOS: Dos 160 casos analisados, cinco apresentaram crise epiléptica, sendo que, um caso, houve a presença de comorbidade com esclerose mesial do hipocampo, comprovada através de ressonância magnética numa paciente com crises parciais complexas iniciadas quinze anos antes do diagnóstico de EM. Nos outros quatro pacientes, as crises ocorreram tanto na fase aguda da doença, como na fase crônica. CONCLUSÃO: A prevalência de crises epiléticas nos pacientes com EM neste estudo foi de 2,5%, semelhante à encontrada em outros estudos.

  1. LIPOMA CEREBRAL EN CUERPO CALLOSO: HALLAZGO INCIDENTAL EN PACIENTE CON EVENTO CEREBROVASCULAR

    Directory of Open Access Journals (Sweden)

    Gloria Cárcamo-Portillo

    2016-07-01

    Full Text Available Los lipomas intracraneales son lesiones infrecuentes y benignas que representan el 0,03 al 0,08% de todas las masas intracraneales. Estos se encuentran relacionados a un defecto de la línea media debido a un mal cierre del tubo neural; lo que conlleva a una mala diferenciación y una persistencia anormal de la meninge primitiva con posterior diferenciación al tejido adiposo. La mitad de los casos permanecen asintomáticos y son diagnosticados como un hallazgo incidental en los estudios imagenológicos. Sin embargo, otros casos se asocian a sintomatología neurológica como retraso psicomotor, cefalea, epilepsia y parálisis cerebral. Se presenta el caso de una paciente de 46 años de edad, con antecedentes de hipertensión arterial y diabetes mellitus tipo 2; que cursa con sintomatología de Evento Cerebrovascular Isquémico por lo que le realizan –una Tomografía Computarizada (TC y una Resonancia Magnética (RM. En el reporte se describen múltiples infartos a nivel del hemisferio cerebral izquierdo mientras que al nivel de la línea media se observó una imagen compatible con lipoma cerebral que afectaba el rostro, la rodilla y la porción anterior del cuerpo calloso. La identificación de este hallazgo fue incidental. Palabras claves: Lipoma Cerebral; Cuerpo Calloso; Resonancia Magnética; Accidente Cerebrovascular. (Fuente: DeCS BIREME.

  2. Paciente con esquizofrenia tratado con ziprasidona + clozapina

    Directory of Open Access Journals (Sweden)

    Pol Yanguas E.

    2013-05-01

    Full Text Available P es un paciente diagnosticado de esquizofrenia, sigue en un piso tutelado un programa de rehabilitación, está medicado con clozapina 500 mg/día y ziprasidona 280 mg/ día. Padece hipercolesterolemia, tabaquismo y sus hábitos alimenticios no son buenos. La medicación que utiliza desde 2007 hasta ahora se refleja en la tabla 1. El último tratamiento se le introdujo el 7 de agosto de 2012, habiendo presentado un electro cardiograma (ECG normal, pero con ligera taquicardia ventricular y prolactinemia de 44,8 ng/ml (valores normales: 2-18 ng/ml.

  3. Inseguridad alimentaria en latinos de California: observaciones de grupos focales Food insecurity among Latinos in California: A focal groups study

    Directory of Open Access Journals (Sweden)

    Hugo Melgar-Quiñonez

    2003-06-01

    Full Text Available OBJETIVO: Estudiar la percepción y la experiencia sobre inseguridad alimentaria entre latinoamericanos de California, así como su interpretación de los insumos incluidos en la Escala de Seguridad Alimentaria. MATERIAL Y MÉTODOS: Entre noviembre y diciembre de 2000, en los condados californianos de Solano y San Joaquín, se efectuaron cuatro grupos focales, con 30 adultos de origen latinoamericano residentes allí. Los comentarios de los participantes fueron codificados por dos investigadores para determinar los temas principales, y fueron confrontados para verificar su convergencia. RESULTADOS: Las preguntas fueron bien comprendidas, no percibiéndose como ofensivas. El marco conceptual se confirmó como "proceso manejado" con diferentes niveles de severidad. Las causas de inseguridad alimentaria identificadas fueron: desempleo, alto costo de algunos alimentos y falta de información nutricional. La necesidad de educación nutricional fue una constante. CONCLUSIONES: Para interpretar datos nacionales de inseguridad alimentaria en latinoamericanos es esencial considerar su percepción particular de ese fenómeno.OBJECTIVE: To assess the perception and experience with food insecurity among Latinos living in California, as well as their interpretation of the items included in the Food Security Scale. MATERIAL AND METHODS: A series of four focus groups were carried out among 30 adults of Latin-American descent living in California. The participant's responses were coded by two researchers to identify the main issues, and to compare them for assessing their convergence. RESULTS: The items were well understood and were not perceived as offensive. The conceptual framework was confirmed as a "managed process" with different severity levels. The causes of food insecurity were: unemployment, high cost of some food items, and lack of nutritional information. The demand for nutritional education was constant. CONCLUSION: Interpreting data on food

  4. Low educational level effects on the performance of healthy adults on a Neuropsychological Protocol suggested by the Commission on Neuropsychology of the Liga Brasileira de Epilepsia

    Directory of Open Access Journals (Sweden)

    Erich Belzunces dos Santos

    2011-10-01

    Full Text Available OBJECTIVE: To assess cognitive measures and impact of education on cognitive performance (CP of low educational levels healthy adults (LELHA on a Neuropsychological Protocol (NP suggested by the Liga Brasileira de Epilepsia. METHOD: 138 subjects from an Education Program for Adults divided into two, age and gender matched groups of 69 subjects, answered the NP: Group 1 (mean of 6.9±2.95 months of formal education and Group 2, 47.8±10 months. Data were compared as z-scores. RESULTS: The mean IQ was 77.1±5.50 and 79.4±3.30 in Groups 1 and 2, respectively (p=0.001. Both performed below the normal curve and Group 1 worse than 2. CP correlated with schooling, especially executive functions (54.1% vs 36.2% and language (52.9% vs 25.7%. CONCLUSION: LELHA showed significant cognitive impairment in verbal and visuospatial areas. If these results had been obtained in epilepsy patients they would be interpreted as global cognitive impairment.

  5. Low educational level effects on the performance of healthy adults on a Neuropsychological Protocol suggested by the Commission on Neuropsychology of the Liga Brasileira de Epilepsia.

    Science.gov (United States)

    dos Santos, Erich Belzunces; Tudesco, Ivanda de Souza Silva; Caboclo, Luis Otávio S F; Yacubian, Elza Márcia T

    2011-10-01

    To assess cognitive measures and impact of education on cognitive performance (CP) of low educational levels healthy adults (LELHA) on a Neuropsychological Protocol (NP) suggested by the Liga Brasileira de Epilepsia. 138 subjects from an Education Program for Adults divided into two, age and gender matched groups of 69 subjects, answered the NP: Group 1 (mean of 6.9 ± 2.95 months of formal education) and Group 2, 47.8 ± 10 months. Data were compared as z-scores. The mean IQ was 77.1 ± 5.50 and 79.4 ± 3.30 in Groups 1 and 2, respectively (p=0.001). Both performed below the normal curve and Group 1 worse than 2. CP correlated with schooling, especially executive functions (54.1% vs 36.2%) and language (52.9% vs 25.7%). LELHA showed significant cognitive impairment in verbal and visuospatial areas. If these results had been obtained in epilepsy patients they would be interpreted as global cognitive impairment.

  6. The Simbol-X Focal Plane

    Science.gov (United States)

    Laurent, P.

    2009-05-01

    The Simbol-X focal plane is designed to detect photons focused by the mirror in the 0.5 to 100 keV energy band. Composed of two detectors, it will measure the position, energy, and arrival time of each incoming X-ray. On top of it will be a collimator to shield all photons not coming from the mirror field of view. The whole system is surrounded by an active and passive shielding in order to ensure the required very low background.

  7. Focal inflammatory diseases of the liver

    International Nuclear Information System (INIS)

    Oto, Aytekin; Akhan, Okan; Oezmen, Mustafa

    1999-01-01

    Inflammatory lesions constitute an important subgroup of focal liver lesions. They may mimic primary or metastatic neoplastic lesions and their differentiation from neoplasia is clinically very important since management of the patient significantly changes. Radiologists should have an important role in both the diagnosis and therapy of these lesions by performing percutaneous aspirations and drainages. In this review we discussed the radiological findings of pyogenic abscesses, amebic abscesses, candidiasis, tuberculosis, hydatic cysts, fascioliasis, ascariasis, schistosomiasis, and sarcoidosis with a special emphasis on US, CT and MR characteristics

  8. Focal inflammatory diseases of the liver

    Energy Technology Data Exchange (ETDEWEB)

    Oto, Aytekin; Akhan, Okan; Oezmen, Mustafa

    1999-10-01

    Inflammatory lesions constitute an important subgroup of focal liver lesions. They may mimic primary or metastatic neoplastic lesions and their differentiation from neoplasia is clinically very important since management of the patient significantly changes. Radiologists should have an important role in both the diagnosis and therapy of these lesions by performing percutaneous aspirations and drainages. In this review we discussed the radiological findings of pyogenic abscesses, amebic abscesses, candidiasis, tuberculosis, hydatic cysts, fascioliasis, ascariasis, schistosomiasis, and sarcoidosis with a special emphasis on US, CT and MR characteristics.

  9. Characterization of DECam focal plane detectors

    Energy Technology Data Exchange (ETDEWEB)

    Diehl, H.Thomas; Angstadt, Robert; Campa, Julia; Cease, Herman; Derylo, Greg; Emes, John H.; Estrada, Juan; Kibik, Donna; Flaugher, Brenna L.; Holland, Steve E.; Jonas, Michelle; /Fermilab /Madrid, CIEMAT /LBL, Berkeley /Argonne /Pennsylvania U.

    2008-06-01

    DECam is a 520 Mpix, 3 square-deg FOV imager being built for the Blanco 4m Telescope at CTIO. This facility instrument will be used for the 'Dark Energy Survey' of the southern galactic cap. DECam has chosen 250 ?m thick CCDs, developed at LBNL, with good QE in the near IR for the focal plane. In this work we present the characterization of these detectors done by the DES team, and compare it to the DECam technical requirements. The results demonstrate that the detectors satisfy the needs for instrument.

  10. ACTIVIDADES DE LA VIDA DIARIA EN ADULTOS MAYORES: LA EXPERIENCIA DE DOS GRUPOS FOCALES

    OpenAIRE

    Christian Oswaldo Acosta Quiroz; Ana Luisa Mónica González-Celis Rangel

    2010-01-01

    El presente estudio tuvo como objetivo obtener una muestra de ejemplos de actividades recreativas físicas y mentales, sociales, de independencia y de protección a la salud, como propuesta inicial de un inventario de actividades de la vida diaria en adultos mayores, a través del desarrollo de dos grupos focales organizados alrededor del tema de actividades cotidianas en ancianos, con ocho y quince adultos mayores, respectivamente. Los resultados reflejan una amplia variedad de actividades de l...

  11. Idiopathic focal epilepsies: the "lost tribe".

    Science.gov (United States)

    Pal, Deb K; Ferrie, Colin; Addis, Laura; Akiyama, Tomoyuki; Capovilla, Giuseppe; Caraballo, Roberto; de Saint-Martin, Anne; Fejerman, Natalio; Guerrini, Renzo; Hamandi, Khalid; Helbig, Ingo; Ioannides, Andreas A; Kobayashi, Katsuhiro; Lal, Dennis; Lesca, Gaetan; Muhle, Hiltrud; Neubauer, Bernd A; Pisano, Tiziana; Rudolf, Gabrielle; Seegmuller, Caroline; Shibata, Takashi; Smith, Anna; Striano, Pasquale; Strug, Lisa J; Szepetowski, Pierre; Valeta, Thalia; Yoshinaga, Harumi; Koutroumanidis, Michalis

    2016-09-01

    The term idiopathic focal epilepsies of childhood (IFE) is not formally recognised by the ILAE in its 2010 revision (Berg et al., 2010), nor are its members and boundaries precisely delineated. The IFEs are amongst the most commonly encountered epilepsy syndromes affecting children. They are fascinating disorders that hold many "treats" for both clinicians and researchers. For example, the IFEs pose many of the most interesting questions central to epileptology: how are functional brain networks involved in the manifestation of epilepsy? What are the shared mechanisms of comorbidity between epilepsy and neurodevelopmental disorders? How do focal EEG discharges impact cognitive functioning? What explains the age-related expression of these syndromes? Why are EEG discharges and seizures so tightly locked to slow-wave sleep? In the last few decades, the clinical symptomatology and the respective courses of many IFEs have been described, although they are still not widely appreciated beyond the specialist community. Most neurologists would recognise the core syndromes of IFE to comprise: benign epilepsy of childhood with centro-temporal spikes or Rolandic epilepsy (BECTS/RE); Panayiotopoulos syndrome; and the idiopathic occipital epilepsies (Gastaut and photosensitive types). The Landau-Kleffner syndrome and the related (idiopathic) epilepsy with continuous spikes and waves in sleep (CSWS or ESES) are also often included, both as a consequence of the shared morphology of the interictal discharges and their potential evolution from core syndromes, for example, CSWS from BECTS. Atypical benign focal epilepsy of childhood also has shared electro-clinical features warranting inclusion. In addition, a number of less well-defined syndromes of IFE have been proposed, including benign childhood seizures with affective symptoms, benign childhood epilepsy with parietal spikes, benign childhood seizures with frontal or midline spikes, and benign focal seizures of adolescence. The

  12. Laparoscopic Partial Hepatectomy of Focal Nodular Hyperplasia

    Directory of Open Access Journals (Sweden)

    Mayu Sakata

    2012-11-01

    Full Text Available Focal nodular hyperplasia is a benign liver lesion incidentally discovered with increasing frequency because of the proliferation of imaging studies. Radiographic characterization can diagnose this pathologic lesion and nonoperative therapy is the standard of care. However, surgical resection may be required for diagnostic reasons or symptomatic patients. Depending on the anatomic location of the lesion, biopsy and/or resection can be performed laparoscopically. We herein report the case of a 26-year-old Japanese woman with a hepatic tumor who required a medical examination. Her medical history was negative for alcohol abuse, oral contraceptive administration and trauma. Clinical examination showed no significant symptoms. Ultrasonography, computed tomography and magnetic resonance imaging showed a mass located in the left lateral segment of the liver with a diameter of about 40 mm. It was difficult to diagnose the tumor definitively from these imaging studies, so we performed laparoscopic partial hepatectomy with successive firing of endoscopic staplers. The histopathological diagnosis was focal nodular hyperplasia. Surgical procedures and postoperative course were uneventful and the patient was discharged from the hospital on postoperative day 5.

  13. CT scan findings in focal epilepsy

    International Nuclear Information System (INIS)

    Kobayashi, Eiki; Mihara, Tadahiro; Yamamoto, Kunimitsu; Yamashita, Kenji; Asakura, Tetsuhiko

    1980-01-01

    In 80 cases of focal epilepsy, excluding such cases as late onset after the age of 30 and traumatic or expansive lesions, the epileptogenic foci have been studied by comparing the CT findings with the seizure types and the EEG findings. The results were as follows: (1) Abnormal CT findings were observed in 36% of the patients. (2) These findings were classified into 4 large groups: localized cerebral atrophy, localized low density, localized high density with contrast enhancement and diffuse cerebral atrophy. (3) The incidence of CT abnormality was higher in the cases with continuous and localized EEG abnormality than in the cases with other types of EEG abnormality. In 48% of the cases, the location of the abnormal CT findings coincided with their EEG foci. (4) In the cases of temporal lobe epilepsy without abnormal CT images, the print-out data compared with the bilateral promised temporal regions, before and after contrast enhancement. The EMI-No. of the medial temporal focus increased more than that of the contralateral side in 3 cases out of 4 after contrast-media injection. (5) Moreover, for the purpose of comparing the CT findings on general seizures with those in focal seizures, we have studied 80 cases of general seizures. In the cases of the general seizures, abnormal CT findings were observed in only 16%. These abnormal findings were diffuse in 5 cases, localized in 6 cases, and combined in 3 cases. (author)

  14. The Sentinel-4 UVN focal plane assemblies

    Science.gov (United States)

    Hinger, Jürgen; Hohn, Rüdiger; Gebhardt, Eyk; Reichardt, Jörg

    2017-09-01

    The Sentinel-4 UVN Instrument is a dispersive imaging spectrometer covering the UV-VIS and the NIR wavelength. It is developed and built under an ESA contract by an industrial consortium led by Airbus Defence and Space. It will be accommodated on board of the MTG-S (Meteosat Third Generation - Sounder) satellite that will be placed in a geostationary orbit over Europe sampling data for generating two-dimensional maps of a number of atmospheric trace gases. The incoming light is dispersed by reflective gratings and detected by the two (UVVIS and NIR) CCDs mounted inside the focal plane assemblies. Both CCD detectors acquire spectral channels and spatial sampling in two orthogonal directions and will be operated at about 215 K mainly to minimize random telegraph signal effects and to reduce dark current. Stringent detector temperature as well as alignment stability requirements of less than +/-0.1 K per day respectively of less than 2 micrometers/2 arcseconds from ground to orbit are driving the FPA thermo-mechanical design. A specific FPA design feature is the redundant LED-calibration system for bad pixel detection as well as pixel gain and linearity monitoring. This paper reports on the design and qualification of the Focal Plane Assemblies with emphasis on thermo-mechanical as well as alignment stability verification.

  15. The Sentinel 4 focal plane subsystem

    Science.gov (United States)

    Hohn, Rüdiger; Skegg, Michael P.; Hermsen, Markus; Hinger, Jürgen; Williges, Christian; Reulke, Ralf

    2017-09-01

    The Sentinel 4 instrument is an imaging spectrometer, developed by Airbus under ESA contract in the frame of the joint European Union (EU)/ESA COPERNICUS program with the objective of monitoring trace gas concentrations. Sentinel 4 will provide accurate measurements of key atmospheric constituents such as ozone, nitrogen dioxide, sulfur dioxide, formaldehyde, as well as aerosol and cloud properties. Sentinel 4 is unique in being the first geostationary UVN mission. The SENTINEL 4 space segment will be integrated on EUMETSAT's Meteosat Third Generation Sounder satellite (MTG-S). Sentinel 4 will provide coverage of Europe and adjacent regions. The Sentinel 4 instrument comprises as a major element two Focal Plane Subsystems (FPS) covering the wavelength ranges 305 nm to 500 nm (UVVIS) and 750 nm to 775 nm (NIR) respectively. The paper describes the Focal Plane Subsystems, comprising the detectors, the optical bench and the control electronics. Further the design and development approach will be presented as well as first measurement results of FPS Qualification Model.

  16. Focal CT abnormality and epileptogenic focus

    International Nuclear Information System (INIS)

    Yagi, Kazuichi; Mihara, Tadahiro; Tottori, Takayasu; Matsuda, Kazumi; Watanabe, Yutaka; Seino, Masakazu

    1989-01-01

    In 31 patients with temporal lobe epilepsy, the precise site of epileptogenic focus was determined by means of a depth EEG recording as one of the presurgical evaluations. In 13 patients, a CT scan revealed focal lesions; 7 in the left temporal lobe and 6 in the right temporal lobe. In 5 of the 7 patients and in 5 of the 6 patients the epileptogenic foci were determined in the temporal lobe on the side of a CT lesion. However, in 2 of the patients with a CT lesion in the left temporal lobe, independent epileptogenic foci were found in both the temporal lobes, and in the other patient with a CT lesion in the right temporal lobe, they were found in the right frontal and left temporal lobes. Thus, the CT lesions agreed in lateralization and focality with the epileptogenic foci in 10 of the 13 patients (77%), but they disagreed in 3 (23%). A CT lesion disclosed in the temporal lobe does not necessarily indicate the side and/or site where the epileptogenic focus may be localized. Although exceptions may be made, spatial disagreement was exemplified between the CT lesion and epileptogenic focus. Therefore, extreme caution has to be taken on the side and/or site of the epileptogenic focus when functional surgical indication is to be made. (author)

  17. Serial neuroradiological studies in focal cerebritis

    International Nuclear Information System (INIS)

    Hatta, S.; Mochizuki, H.; Kuru, Y.; Miwa, H.; Kondo, T.; Mori, H.; Mizuno, Y.

    1994-01-01

    We report serial neuroradiological studies in a patient with focal cerebritis in the head of the left caudate nucleus. On the day after the onset of symptoms, CT showed an ill-defined low density lesion. The lack of contrast enhancement appeared to be the most important finding for differentiating focal cerebritis from an encapsulated brain abscess or a tumour. MRI two days later revealed the centre of the lesion to be of slightly low intensity on T1-weighted inversion recovery (IR) images and very low intensity on T2-weighted spin echo images, which appeared to correspond to the early cerebritis stage of experimentally induced cerebritis and brain abscess. Ten days after the onset of symptoms, CT revealed a thin ring of enhancement in the head of the caudate nucleus, and a similar small ring was seen in the hypothalamus 16 days after the onset, corresponding to the late cerebritis stage. MRI nine days later revealed ill-defined high signal lesions within the involved area on the T1-weighted IR images. To our knowledge, this is the first published MRI documentation of the early cerebritis stage developing into an encapsulated brain abscess. The mechanisms underlying of these radiographic changes are discussed. (orig.)

  18. Structural and effective connectivity in focal epilepsy

    Directory of Open Access Journals (Sweden)

    Christopher S. Parker

    2018-01-01

    Full Text Available Patients with medically-refractory focal epilepsy may be candidates for neurosurgery and some may require placement of intracranial EEG electrodes to localise seizure onset. Assessing cerebral responses to single pulse electrical stimulation (SPES may give diagnostically useful data. SPES produces cortico-cortical evoked potentials (CCEPs, which infer effective brain connectivity. Diffusion-weighted images and tractography may be used to estimate structural brain connectivity. This combination provides the opportunity to observe seizure onset and its propagation throughout the brain, spreading contiguously along the cortex explored with electrodes, or non-contiguously. We analysed CCEPs and diffusion tractography in seven focal epilepsy patients and reconstructed the effective and structural brain networks. We aimed to assess the inter-modal similarity of the networks at a large scale across the cortex, the effective and structural connectivity of the ictal-onset zone, and investigate potential mechanisms of non-contiguous seizure spread. We found a significant overlap between structural and effective networks. Effective network CCEP amplitude, baseline variation, and outward connectivity was higher at ictal-onset zones, while structural connection strength within the ictal-onset zone tended to be higher. These findings support the concept of hyperexcitable cortex being associated with seizure generation. The high prevalence of structural and effective connections from the ictal-onset zone to sites of non-contiguous spread suggests that macroscopic structural and effective connections are plausible routes for non-contiguous seizure spread.

  19. Ultrasound elastographic techniques in focal liver lesions.

    Science.gov (United States)

    Conti, Clara Benedetta; Cavalcoli, Federica; Fraquelli, Mirella; Conte, Dario; Massironi, Sara

    2016-03-07

    Elastographic techniques are new ultrasound-based imaging techniques developed to estimate tissue deformability/stiffness. Several ultrasound elastographic approaches have been developed, such as static elastography, transient elastography and acoustic radiation force imaging methods, which include point shear wave and shear wave imaging elastography. The application of these methods in clinical practice aims at estimating the mechanical tissues properties. One of the main settings for the application of these tools has been liver stiffness assessment in chronic liver disease, which has been studied mainly using transient elastography. Another field of application for these techniques is the assessment of focal lesions, detected by ultrasound in organs such as pancreas, prostate, breast, thyroid, lymph nodes. Considering the frequency and importance of the detection of focal liver lesions through routine ultrasound, some studies have also aimed to assess the role that elestography can play in studying the stiffness of different types of liver lesions, in order to predict their nature and thus offer valuable non-invasive methods for the diagnosis of liver masses.

  20. Focal fatty infiltra- tion and focal fatty sparing of the liver

    African Journals Online (AJOL)

    Enrique

    Department of Radiology. Nelson Mandela School of Health Sciences. Durban. Fig. 1a. Unenhanced CT of the liver in case 1 demonstrates multiple focal low density regions in both lobes of the liver. Region of interest 1 over the fatty left lobe measured 10 HU while region of interest 2 over the right lobe measure 40 HU in.

  1. Sistema colinérgico: revisitando receptores, regulação e a relação com a doença de Alzheimer, esquizofrenia, epilepsia e tabagismo

    OpenAIRE

    Ventura,Ana L. M.; Abreu,Paula A.; Freitas,Rodrigo C. C.; Sathler,Plínio C.; Loureiro,Natália; Castro,Helena C.

    2010-01-01

    OBJETIVO: Revisar a estrutura e o funcionamento do sistema colinérgico central ressaltando seu papel na fisiologia e na fisiopatologia das doenças de Alzheimer e Parkinson, esquizofrenia, epilepsia e tabagismo. MÉTODO: Foi realizada uma pesquisa bibliográfica no MedLine, LILACS, PubMed e ISI, e na Biblioteca da Fundação Oswaldo Cruz, RJ, selecionando-se o período de 1914 a 2009, utilizando os descritores: "receptors", "cholinergic", "Alzheimer disease", "schizophrenia", "epilepsy" e "smoking"...

  2. The mistery of Gustave Flaubert's death: could sudden unexpected death in epilepsy be part of the context? O mistério da morte de Gustave Flaubert: pode a morte súbita em epilepsia fazer parte o contexto?

    Directory of Open Access Journals (Sweden)

    Marly de Albuquerque

    2009-06-01

    Full Text Available Epilepsy is the most common serious neurological condition and sudden unexpected death in epilepsy (SUDEP is the most important direct epilepsy-related cause of death. Information concerning risk factors for SUDEP is conflicting, but high seizure frequency is a potential risk factor. Additionally, potential pathomechanisms for SUDEP are unknown, but it is very probable that cardiac arrhythmias during and between seizures or transmission of epileptic activity to the heart via the autonomic nervous system potentially play a role. More than two decades ago, temporal lobe epilepsy was suggested as having been the ''nervous disease'' of Gustave Flaubert, one of the most important French novelists. In these lines, as the circumstances of his death were the subject of fabulous and mysterious speculations, we postulated in this paper that Falubert' death could be due SUDEP phenomenon.A epilepsia é a condição neurológica crônica grave mais comum e a morte súbita em epilepsia (SUDEP é a mais importante causa de morte diretamente relacionada à epilepsia. Informações sobre fatores de risco para SUDEP são conflitantes, porém, a alta freqüência de crises epilépticas é um fator de risco em potencial. Além disso, os mecanismos causais para SUDEP ainda não estão conhecidos, mas é muito provável que arritmias cardíacas durante e entre as crises epilépticas ou a transmissão da atividade epiléptica para o coração via sistema nervoso autônomo desempenhem um importante papel. Mais de duas décadas atrás, foi proposto que a "doença nervosa" de Gustave Flaubert, um dos mais importantes novelistas franceses, era epilepsia do lobo temporal. Nesse sentido, como a morte de Gustave Flaubert ainda seja motivo de misteriosa especulação, nosso artigo propõe que a mesma poderia estar relacionada ao fenômeno de SUDEP.

  3. Avaliação pelo P300 de crianças com e sem epilepsia e rendimento escolar Assessment through P300 of epileptic and non-epileptic children and school performance

    Directory of Open Access Journals (Sweden)

    JUCELEI F. VISIOLI-MELO

    2000-06-01

    Full Text Available Dificuldade de aprendizagem é situação comum em crianças com epilepsia. Distúrbios da inteligência têm sido associados com epilepsia. O potencial cognitivo (P300 é um adjunto clínico para mensurar neurofisiologicamente o processo cognitivo. Foram estudadas 99 crianças com 10 anos a 11 anos e 11 meses. Do Grupo I, sem epilepsia, faziam parte 64 crianças, das quais 32 com bom rendimento e outras 32 com mau rendimento escolar. Do Grupo II, com epilepsia, faziam parte 35 crianças, sendo 21 com bom rendimento escolar e 15 com mau rendimento escolar. Não foi encontrada diferença significativa na latência do P300 entre os dois grupos. Quando foram estratificados segundo o desempenho escolar, as crianças do Grupo I, com bom rendimento escolar, apresentaram latência do P300 de 336 ms e as com mau rendimento escolar, latência de 382 ms; as crianças do Grupo II, com bom rendimento escolar, apresentaram latência do P300 de 363 ms e as com mau rendimento escolar, latência de 400 ms, com diferença significativa. Essa diferença estava localizada entre as crianças não epilépticas com bom desempenho escolar e as com mau desempenho escolar, epilépticas ou não.Learning disability is common in epileptic children. Epilepsy has been associated with disorders of intelligence. Cognitive potential (P300 is considered to be a clinical aid in the neurophysiological measurement of the cognitive process. Ninety-nine children between the ages of 10 years and 11 years and 11 months formed our sample, with good and poor school performance. Group I, non-epileptic, had 64 children of whom 32 had good and 32 poor school performance. Group II, epileptic, had 35 children, of whom 21 had good and 15 poor school performance. No significant difference in P300 latency was found between Groups I and II. When groups were stratified based on school performance, Group I children with good school performance had P300 latency of 336 ms, while the ones with poor

  4. First, do no harm: the risks of overtreating children with epilepsy Primeiramente, não causar dano: os riscos do excesso de medicações no tratamento da epilepsia na infância

    Directory of Open Access Journals (Sweden)

    Eunice Chuang

    2007-03-01

    Full Text Available BACKGROUND: Although overtreatment with antiepileptic drugs contributes to the morbidity associated with epilepsy, many children still are overtreated. OBJECTIVE: To evaluate if the withdrawal of at least one antiepileptic drug (AED in children with refractory epilepsy using polytherapy enable a better seizure control. METHOD: This was a prospective study. Children with refractory epilepsy using at least two AEDs were included. Once the patient, or guardian, agreed to participate in the study, one or more AED were slowly tapered off. The remaining AEDs dosages could be adjusted as needed, but a new AED could not be introduced. RESULTS: Fifteen patients were evaluated, three girls; ages ranging from 3 to 18 (mean=8.7 years. After at least one AED withdrawal, two (13.5% patients became seizure free, seizures improved >50% in 5 (33.5% patients, did not change in 5 (33.5%, and seizure frequency became worse in 3 (20%. Adverse events improved in 12 patients (80%. CONCLUSION: The withdrawal of at least one AED is a valuable option in the treatment of selected children with refractory epilepsy.INTRODUÇÃO: Apesar do tratamento excessivo com drogas antiepilépticas (DAE contribuir para a morbidade associada à epilepsia, muitas crianças ainda são submetidas a politerapia desnecessária. OBJETIVO: Avaliar se a retirada de pelo menos uma DAE em crianças com epilepsia refratária utilizando politerapia pode proporcionar melhor controle das crises epilépticas. MÉTODOS: Este foi um estudo prospectivo. Crianças com epilepsia refratária em uso de pelo menos duas DAE foram incluídas. Após assinatura do consentimento informado, uma ou mais DAE foram lentamente retiradas. As doses das outras DAE que não foram retiradas poderiam ser ajustadas se necessário, mas uma nova DAE não pode ser introduzida. RESULTADOS: Quinze pacientes foram avaliados, três eram meninas, com idades entre 3 e 18 anos (média=8,7. Após a retirada de pelo menos uma DAE, 2 (13

  5. Avaliação do perfil metabólico, nutricional e efeitos adversos de crianças com epilepsia refratária em uso da dieta cetogênica

    OpenAIRE

    Rizzutti,Sueli; Ramos,Ana Maria Figueiredo; Cintra,Isa de Pádua; Muszkat,Mauro; Gabbai,Alberto Alain

    2006-01-01

    OBJETIVO: Avaliar os efeitos adversos, o perfil metabólico e o crescimento pôndero-estatural de crianças com crises epilépticas de difícil controle, as quais foram submetidas a dieta cetogênica. MÉTODOS: Selecionaram-se 23 pacientes na faixa etária de 2 até 17 anos com epilepsia de difícil controle medicamentoso, sendo 43,5% (n=10) do sexo masculino e 56,5% (n=13) do sexo feminino, provenientes do Setor de Neuropediatria da Disciplina de Neurologia da Universidade Federal de São Paulo. Foram ...

  6. Manejo da epilepsia na rede básica de saúde no Brasil: os profissionais estão preparados? Managing epilepsy in the primary care network in Brazil: are health professionals prepared?

    Directory of Open Access Journals (Sweden)

    Li Min Li

    2005-11-01

    Full Text Available OBJETIVO: Identificar a percepção quanto à epilepsia dos profissionais médicos e não-médicos que atuam na rede básica de saúde no Brasil. MÉTODO: Os dados foram coletados durante o VI Congresso Brasileiro de Medicina de Família e Comunidade e VI Congresso de Medicina Familiar, realizados em 2004 no Rio de Janeiro, com 1 200 participantes de todo o Brasil. Foram aplicados dois questionários, um para os médicos e outro para profissionais não-médicos da área da saúde. RESULTADOS: Quinhentas e noventa e oito pessoas responderam aos questionários. Tanto os 345 médicos como os 253 não-médicos mostraram uma percepção adequada sobre a epilepsia. A porcentagem média estimada (auto-informada de pessoas com epilepsia na população atendida pelos profissionais que participaram do estudo foi de 0,78% (286 respostas; 0 a 8%; mediana = 0,37%; de pacientes com crises controladas, 60%; de pacientes em monoterapia, 55%; de médicos que encaminhavam seus pacientes para o neurologista, 59%; e de pacientes que estavam trabalhando ou estudando, 56%. Do total de médicos, 252 (73% informaram não se sentir seguros no manejo de pessoas com epilepsia, enquanto 84 (24% sentiam-se seguros e nove (3% não sabiam; dos 252 médicos que se sentiam inseguros, 226 (90% disseram que participariam de um treinamento para melhorar a qualidade do atendimento médico na epilepsia. CONCLUSÃO: Os profissionais que participaram do estudo, atuantes no sistema básico de saúde, indicaram que o sistema tem os elementos fundamentais para o tratamento integral da epilepsia. Contudo, para garantir o estabelecimento de um programa efetivo e eficiente de manejo da epilepsia na rede básica, são necessárias: uma rede de referência e contra-referência, a distribuição contínua de drogas anti-epilépticas, a monitorização do manejo da epilepsia pelo Sistema de Informação da Atenção Básica do governo federal e a educação continuada de profissionais de sa

  7. CT appearance of focal fatty infiltration of the liver

    International Nuclear Information System (INIS)

    Halvorsen, R.A.; Korobkin, M.; Ram, P.C.; Thompson, W.M.

    1982-01-01

    Focal fatty infiltration of the liver is an entity that may be confused with liver metastasis on computed tomography (CT). The imaging results and medical records of 16 patients with CT appearance suggestive of focal fatty liver were reviewed, three of whom had the simultaneous presence of metastitic liver disease. Focal fatty liver often has a distinctive appearance with CT, usually with a nonspherical shape, absence of mass effect, and density close to water. Liver metastases are usually round or oval, and unless cystic or necrotic, they have CT attenuation values closer to normal liver parenchyma than water. A radionuclide liver scan almost always resolves any confusion about the differential diagnosis of focal fatty liver: a well defined focus of photon deficiency is due to neoplasm rather than focal fatty infiltration. Sonography sometimes helps to confirm the CT impression, but may be misleading if the diagnosis of focal or diffuse fatty infiltration is not suspected before the examination

  8. The study of the focal trough in panoramic radiograph

    International Nuclear Information System (INIS)

    Park, C. S.; Kim, H. P.

    1982-01-01

    In the study of the focal trough of panoramic radiograph, using the Moritta company Panex EC a series of 48 exposures were taken with the 6-18 brass pins placed in the holes of the plastic model plate, then evaluated by 4 observers. The author analyzed the focal trough defined by the sharpness criteria and calculated the vertical and horizontal magnification range in the corrected focal trough. The results were as follows; 1. Continuous focal trough was not defined in the anterior region using a very high degree of sharpness. 2. As degree of sharpness used in the analysis became less, focal trough was continuous in the anterior and posterior regions, symmetrized bilaterally, and the widths of the focal trough increased more in the posterior region. 3. As sharpness criteria were reduced, the percentage range of image magnification increased in both vertical and horizontal magnification, and especially the percentage range of horizontal magnification was greater than that of vertical magnification.

  9. Multi-focal Vision and Gaze Control Improve Navigation Performance

    Directory of Open Access Journals (Sweden)

    Kolja Kuehnlenz

    2008-11-01

    Full Text Available Multi-focal vision systems comprise cameras with various fields of view and measurement accuracies. This article presents a multi-focal approach to localization and mapping of mobile robots with active vision. An implementation of the novel concept is done considering a humanoid robot navigation scenario where the robot is visually guided through a structured environment with several landmarks. Various embodiments of multi-focal vision systems are investigated and the impact on navigation performance is evaluated in comparison to a conventional mono-focal stereo set-up. The comparative studies clearly show the benefits of multi-focal vision for mobile robot navigation: flexibility to assign the different available sensors optimally in each situation, enhancement of the visible field, higher localization accuracy, and, thus, better task performance, i.e. path following behavior of the mobile robot. It is shown that multi-focal vision may strongly improve navigation performance.

  10. Resultados de la terapia por onda de choque focal en calcificaciones del manguito rotador. [Results of focal shock-wave therapy for calcifyng tendinitis of the rotatorr cuff

    Directory of Open Access Journals (Sweden)

    Daniel Moya

    2013-01-01

    Full Text Available Introducción El objetivo del presente trabajo es evaluar, en forma prospectiva, los resultados del tratamiento mediante la aplicación de ondas de choque focales, en un grupo de pacientes con calcificaciones sintomáticas del manguito rotador. Material y métodos Se incluyeron 44 casos consecutivos de calcificaciones localizadas en alguno de los tendones del manguito rotador, en 43 pacientes con cirugías fallidas o tratamiento previo, al menos, por 6 meses, con síntomas persistentes. Resultados En la evaluación al año, la calcificación había desaparecido completamente en 20 pacientes (45,5%. En 13 casos (29,5%, hubo un cambio significativo en el tamaño o la densidad. En 11 casos (25%, no hubo modificaciones. El dolor, según la escala analógica visual descendió de un promedio de 5,5 a 1,4 (p <0,0001. El puntaje de UCLA pasó de un valor inicial promedio de 15,7 a un valor de 29,3 (p <0,0001. El puntaje de Autoevaluación ASES fue de 84,6 comparado con un valor inicial de 48 (p <0,0001. El 77% de los pacientes estuvieron satisfechos con el procedimiento. Conclusión El estudio sugiere que la terapia por onda de choque es una alternativa válida para pacientes que no han respondido al tratamiento conservador ni al quirúrgico

  11. Focal cemento-osseous dysplasia of mandible.

    Science.gov (United States)

    Cankaya, Abdülkadir Burak; Erdem, Mehmet Ali; Olgac, Vakur; Firat, Deniz Refia

    2012-09-03

    Fibro-osseous lesions are disturbances in bone metabolism in which normal bone is replaced by a connective tissue matrix that then gradually develops into cemento-osseous tissue. Typically, the lesion is asymptomatic and is detected on routine radiographic examination. Radiologically, this lesion has three stages of maturation: pure radiolucent, radiopaque/mixed radiolucent, and radiopaque appearance. During these stages the lesion can be misdiagnosed. In this case report a 69-year- old patient with a a complaint of painless swelling of the left mandibular molar and premolar area is presented along with a review of the differential diagnoses considered in order to reach a final diagnosis of focal cemento-osseous dysplasia.

  12. Strong reducing of the laser focal volume

    CSIR Research Space (South Africa)

    Godin, T

    2011-08-01

    Full Text Available equal to -1 or +1 modeled on the p light rings of the incident TEMp0 beam. The transformation quality of a 30TEM beam into a single-lobed pattern in the focal plane is shown in Fig. 3. It is clear that the intensity pattern of the rectified beam... DOE (blue solid line), rectified 30TEM (red solid line) -3 -2 -1 0 1 2 3 0 1 2 3 4 z=0 z=f DOE Fig. 2 -60 -50 -40 -30 -20 -10 0 10 20 30 40 50 60 0,0 0,2 0,4 0,6 0,8 1,0 TEM30 without DOE "rectified" TEM30 TEM00 In te ns...

  13. Smart trigger logic for focal plane arrays

    Science.gov (United States)

    Levy, James E; Campbell, David V; Holmes, Michael L; Lovejoy, Robert; Wojciechowski, Kenneth; Kay, Randolph R; Cavanaugh, William S; Gurrieri, Thomas M

    2014-03-25

    An electronic device includes a memory configured to receive data representing light intensity values from pixels in a focal plane array and a processor that analyzes the received data to determine which light values correspond to triggered pixels, where the triggered pixels are those pixels that meet a predefined set of criteria, and determines, for each triggered pixel, a set of neighbor pixels for which light intensity values are to be stored. The electronic device also includes a buffer that temporarily stores light intensity values for at least one previously processed row of pixels, so that when a triggered pixel is identified in a current row, light intensity values for the neighbor pixels in the previously processed row and for the triggered pixel are persistently stored, as well as a data transmitter that transmits the persistently stored light intensity values for the triggered and neighbor pixels to a data receiver.

  14. Pharmacological response of systemically derived focal epileptic lesions

    Energy Technology Data Exchange (ETDEWEB)

    Remler, M.P.; Sigvardt, K.; Marcussen, W.H.

    1986-11-01

    Focal epileptic lesions were made in rats by systemic focal epileptogenesis. In this method, a focal lesion of the blood-brain barrier (BBB) is produced by focal alpha irradiation followed by repeated systemic injection of a convulsant drug that cannot cross the normal BBB, resulting in a chronic epileptic focus. Changes in the spike frequency of these foci in response to various drugs was recorded. The controls, saline and chlorpromazine, produced no change. Phenytoin, phenobarbital, chlordiazepoxide, and valproic acid produced the expected decrease in spike frequency. Pentobarbital and diazepam produced a paradoxical increase in spike frequency.

  15. Focal cryotherapy: step by step technique description

    Directory of Open Access Journals (Sweden)

    Cristina Redondo

    Full Text Available ABSTRACT Introduction and objective: Focal cryotherapy emerged as an efficient option to treat favorable and localized prostate cancer (PCa. The purpose of this video is to describe the procedure step by step. Materials and methods: We present the case of a 68 year-old man with localized PCa in the anterior aspect of the prostate. Results: The procedure is performed under general anesthesia, with the patient in lithotomy position. Briefly, the equipment utilized includes the cryotherapy console coupled with an ultrasound system, argon and helium gas bottles, cryoprobes, temperature probes and an urethral warming catheter. The procedure starts with a real-time trans-rectal prostate ultrasound, which is used to outline the prostate, the urethra and the rectal wall. The cryoprobes are pretested and placed in to the prostate through the perineum, following a grid template, along with the temperature sensors under ultrasound guidance. A cystoscopy confirms the right positioning of the needles and the urethral warming catheter is installed. Thereafter, the freeze sequence with argon gas is started, achieving extremely low temperatures (-40°C to induce tumor cell lysis. Sequentially, the thawing cycle is performed using helium gas. This process is repeated one time. Results among several series showed a biochemical disease-free survival between 71-93% at 9-70 month- follow-up, incontinence rates between 0-3.6% and erectile dysfunction between 0-42% (1–5. Conclusions: Focal cryotherapy is a feasible procedure to treat anterior PCa that may offer minimal morbidity, allowing good cancer control and better functional outcomes when compared to whole-gland treatment.

  16. Videojuego con Realidad Virtual

    OpenAIRE

    González Mora, César

    2017-01-01

    El objetivo del proyecto es el desarrollo de un videojuego deportivo que utilice realidad mixta. El videojuego se podrá utilizar con dispositivos de tipo cardboard, y utilizará realidad aumentada para la interacción del jugador con el videojuego. En el desarrollo se utilizará el motor Unity para conseguir una aplicación multiplataforma, y la librería Vuforia para implementar realidad mixta.

  17. Sistemas integrados con Arduino

    OpenAIRE

    EL YAKOUTI, MOHAMMED

    2017-01-01

    Design of a robot prototype remotely controllable from Bluetooth using Arduino. Control and testing of sensors and events interacting with Arduino and Bluetooth. Diseño de un prototipo de robot controlable remotamente con Bluetooth utilizando Arduino. Control y verificación de los sensores y eventos que interactúan mediante el Arduino y el Bluetooth. El Yakouti, M. (2017). Sistemas integrados con Arduino. http://hdl.handle.net/10251/89274. TFGM

  18. Epilepsia e síndrome de turner apresentação de um caso e revisão da literatura

    Directory of Open Access Journals (Sweden)

    P. C. Trevisol-Bittencourt

    1990-09-01

    Full Text Available Henry Turner descreveu, em 1938, síndrome caracterizada por infantilismo sexual, pescoço alado e cubitus valgus. Disgenesia gonadal foi acrescentada à síndrome nos anos subsequentes e o critério exigido para sua confirmação diagnostica é a demonstração de cariótipo anormal, no qual é inexistente uma porção ou todos os de um cromossoma X. Ainda que nos dias atuais haja muita informação geral disponível sobre a síndrome de Turner, em relação a suas possíveis complicações neurológicas há inexplicável negligência. Nesta comunicação revemos o caso de uma paciente com esta síndrome, que desenvolveu epilepsia severa a partir dos 16 anos de idade. Em complementação, revisão das publicações sobre o assunto nos últimos 20 anos, com ênfase às alterações neurológicas associadas à condição, é apresentada. O constante aparecimento de malformações extracranianas, muitas das quais estando empírica e freqüentemente combinadas a anomalias no SNC, bem como a incidência relativamente alta de deficits nestas pacientes, parecem justificar a hipótese de que em certa porcentagem de casos, uma malformação do SNC, não necessariamente de tipo vascular, poderá ser parte ainda não descrita da síndrome.

  19. Fewer specialists support using medical marijuana and CBD in treating epilepsy patients compared with other medical professionals and patients: result of Epilepsia's survey.

    Science.gov (United States)

    Mathern, Gary W; Beninsig, Laurie; Nehlig, Astrid

    2015-01-01

    From May 20 to September 1 2014, Epilepsia conducted an online survey seeking opinions about the use of medical marijuana and cannabidiol (CBD) for people with epilepsy. This study reports the findings of that poll. The survey consisted of eight questions. Four questions asked if there were sufficient safety and efficacy data, whether responders would advise trying medical marijuana in cases of severe refractory epilepsy, and if pharmacologic grade compounds containing CBD should be available. Four questions addressed occupation, geographic region of residence, if responders had read the paper, and if they were International League Against Epilepsy/International Bureau for Epilepsy (ILAE/IBE) members. Of 776 who started or completed the survey, 58% were patients from North America, and 22% were epileptologists and general neurologists from Europe and North America. A minority of epileptologists and general neurologists said that there were sufficient safety (34%) and efficacy (28%) data, and 48% would advise using medical marijuana in severe cases of epilepsy. By comparison, nearly all patients and the public said there were sufficient safety (96%) and efficacy (95%) data, and 98% would recommend medical marijuana in cases of severe epilepsy. General physicians, basic researchers, nurses, and allied health professions sided more with patients, saying that there were sufficient safety (70%) and efficacy (71%) data, and 83% would advise using marijuana in severe cases. A majority (78%) said there should be pharmacologic grade compounds containing CBD, and there were no differences between specialists, general medical personal, and patients and the public. This survey indicates that there is a wide disparity in opinion on the use of medical marijuana and CBD in the treatment of people with epilepsy, which varied substantially, with fewer medical specialists supporting its use compared with general medical personal, and patients and the public. Wiley Periodicals, Inc

  20. Questionário de qualidade de vida na epilepsia: resultados preliminares Protocol of quality of life in epilepsy: first results

    Directory of Open Access Journals (Sweden)

    Elisabete Abib Pedroso de Souza

    2001-09-01

    Full Text Available Crises epilépticas acontecem por breves períodos de tempo, mas os sentimentos de ansiedade e desamparo, adaptação às restrições impostas aos estilos de vida e uma variedade de outros problemas afetam mais a qualidade de vida (QV dos portadores de epilepsia. Este estudo propõe um protocolo que contempla os objetivos de uma avaliação de QV na saúde e seja aplicado a uma população que frequenta um hospital universitário. Consta de 65 itens e avalia o funcionamento psicossocial, limitações físicas, aspecto cognitivo, percepção de controle, auto-conceito, bem como percepção de saúde e QV. Os resultados de validação e confiabilidade são discutidos.Seizures happen for brief periods of time, but the feelings of anxiety and helplessness, adaptation to the restrictions impose by the life-style and variety of other problems affect more the quality of life in epilepsy. This study proposes a protocol that regards the objectives of a quality of life assessment in health and is applied to a population that attends a university hospital. It contains 65 items and assesses the psychosocial performance, physical limitation, cognitive aspects, perception of control, self-concept, as well as perception of health and quality of life. The results of reliability and validity are discussed.

  1. Investigando con personas con dificultades de aprendizaje

    Directory of Open Access Journals (Sweden)

    Borja González Luna

    2013-12-01

    Full Text Available El artículo muestra los orígenes de lo que Walmsley (2008 denomina «investigación inclusiva». Para comprender qué se entiende por investigación inclusiva tenemos que remontarnos a los debates epistemológicos sobre las metodologías cuantitativas y cualitativas, acontecidos en la década de los 90, en torno a la revista Disability & Society. A partir de una síntesis de dichos debates, focalizados en el ámbito de la «discapacidad intelectual y del desarrollo», se exponen dos estrategias de colaboración con dicha población: a una aproximación etnográfica (de trabajo grupal, y b una aproximación biográfica (de trabajo individual. A continuación se esboza un posible diseño de trabajo de campo que intenta superar el paradigma cualitativo «clásico» con el objetivo de incluir a dicho colectivo más allá del rol de «sujetos de la investigación». Para finalizar se recoge el debate sobre la accesibilidad de los resultados de la investigación a los participantes en dichas investigaciones, y con ello la necesaria innovación en el ámbito de las «devoluciones» de los resultados, cuando se trata de incluir a personas que presentan limitaciones para la comprensión del lenguaje abstracto oral y/o escrito.

  2. Demonstration project on epilepsy in Brazil: outcome assessment Projeto demonstrativo em epilepsia no Brasil: avaliação do desfecho

    Directory of Open Access Journals (Sweden)

    Li M. Li

    2007-06-01

    managers.OBJETIVO: Avaliar o resultado do tratamento de pacientes com epilepsia na atenção básica sob o modelo proposto pelo Projeto Demonstrativo no Brasil, como parte da Campanha Global Contra a Epilepsia da WHO/ILAE/IBE. MÉTODO: Avaliamos o resultado do tratamento nos pacientes acompanhados em quatro unidades básicas de saúde. As equipes de saúde fizeram um treinamento padrão. O resultado do tratamento foi baseado em cinco aspectos: 1 redução da freqüência das crises, 2 percepção subjetiva dos pacientes e dos médicos, 3 redução de absenteísmo, 4 integração social (escola, trabalho, e 5 senso de independência. RESULTADOS: Um total de 181 pacientes (93 mulheres - 51%, com uma média de 38 anos (variando de 2 a 86 anos entraram nesta análise. O tempo médio de seguimento foi de 26 meses (variou de 1 a 38 meses, 11 pacientes tinham seguimento menos de 12 meses. A freqüência das crises foi categorizada variando de 0 (sem nenhuma crise nos últimos 24 meses a 7 (>10 crises/dia. O escore mediano da freqüência de crises no começo era de 3 (uma a três crises por mês. O escore mediano da freqüência de crises no final era de 1 (uma a três crises por ano. A opinião dos pacientes e familiares é que a maioria (106 casos houve uma melhora importante na saúde, 34 tiveram pouca melhora, 37 não tiveram mudanças e em quatro houve piora. Em relação ao absenteísmo, integração social e senso de independência houve pouca melhora. DISCUSSÃO: O modelo desenvolvido de tratamento de epilepsia na atenção primária com base na estrutura de saúde existente, com estratégias centradas nos profissionais de saúde e na comunidade, provou ser efetivo com redução importante na freqüência das crises bem como na melhora em geral da saúde. Esse modelo pode ser aplicado em âmbito nacional, pois os elementos chaves já existem, desde que essas estratégias sejam pactuadas com os organismos locais de saúde.

  3. Sighting optics including an optical element having a first focal length and a second focal length and methods for sighting

    Science.gov (United States)

    Crandall, David Lynn

    2011-08-16

    Sighting optics include a front sight and a rear sight positioned in a spaced-apart relation. The rear sight includes an optical element having a first focal length and a second focal length. The first focal length is selected so that it is about equal to a distance separating the optical element and the front sight and the second focal length is selected so that it is about equal to a target distance. The optical element thus brings into simultaneous focus for a user images of the front sight and the target.

  4. Radiologic manifestations of focal cerebral hyperemia in acute stroke

    DEFF Research Database (Denmark)

    Olsen, Tom Skyhøj; Skriver, E B; Herning, M

    1991-01-01

    In 16 acute stroke patients with focal cerebral hyperemia angiography and regional cerebral blood flow (rCBF) were studied 1 to 4 days post stroke. CT was performed twice with and without contrast enhancement 3 +/- 1 days and 16 +/- 4 days post stroke. Angiographic evidence of focal cerebral hype...

  5. Focal decompositions for linear differential equations of the second order

    Directory of Open Access Journals (Sweden)

    L. Birbrair

    2003-01-01

    two-points problems to itself such that the image of the focal decomposition associated to the first equation is a focal decomposition associated to the second one. In this paper, we present a complete classification for linear second-order equations with respect to this equivalence relation.

  6. Focal necrotizing pneumonia is a distinct entity from lung abscess.

    Science.gov (United States)

    Seo, Hyewon; Cha, Seung-Ick; Shin, Kyung-Min; Lim, Jaekwang; Yoo, Seung-Soo; Lee, Jaehee; Lee, Shin-Yup; Kim, Chang-Ho; Park, Jae-Yong

    2013-10-01

    'Focal necrotizing pneumonia' was defined as a localized type of necrotizing pneumonia characterized by a single or few cavities of low density without rim enhancement on computed tomography (CT) scan. The purpose of this study was to investigate the clinical features and course of patients with focal necrotizing pneumonia, thereby elucidating its clinical relevance. The present study was conducted retrospectively in patients who had been interpreted as having lung abscess or necrotizing pneumonia on CT scan. Clinical and radiological characteristics were compared between the focal necrotizing pneumonia and lung abscess groups. Overall, 68 patients with focal necrotizing pneumonia (n = 35) or lung abscess (n = 33) were included in the present study. The frequency of risk factors for aspiration was significantly lower in the focal necrotizing group, compared with the lung abscess group (14.3% vs 45.5%, P = 0.005). Compared with lung abscess, focal necrotizing pneumonia was observed more commonly in non-gravity-dependent segments (66% vs 36%, P lung abscess group (31% vs 12%, P = 0.08). However, in terms of treatment outcomes, a similar high rate of success was observed in both groups: 97%, respectively. Compared to lung abscess, focal necrotizing pneumonia occurs more commonly in non-gravity-dependent segments with lower incidence of risk factors for aspiration. Similar to lung abscess, the rate of success for treatment of focal necrotizing pneumonia was high. © 2013 The Authors. Respirology © 2013 Asian Pacific Society of Respirology.

  7. Proximal Focal Femoral Deficiency in Ibadan a Developing ...

    African Journals Online (AJOL)

    The cultural aversion to amputation in our environment makes it difficult to employ that option of treatment. Proximal focal femoral deficiency in Ibadan a developing country's perspective and a review of the literature. Keywords: Proximal focal femoral deficiency , congenital malformations , limb malformations , lower limb ...

  8. Concordance of MRI and EEG Focal Slowing in Nonsyndromic Epilepsy

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2013-04-01

    Full Text Available Investigators at the Kangwon National University, Korea, and The Epilepsy Center, Lurie Children’s Hospital of Chicago, USA studied the correlation and significance of EEG focal slowing and focal MRI abnormalities in 253 children with nonsyndromic epilepsy.

  9. Síndromes epilépticos en niños y adolescentes

    Directory of Open Access Journals (Sweden)

    López S. Isabel Margarita, Dra.

    2013-11-01

    Full Text Available En la edad pediátrica las epilepsias son frecuentes, con manifestaciones clínicas diversas y edad-dependientes. El reconocimiento preciso de los diferentes síndromes y epilepsias es importante para determinar un tratamiento y pronóstico adecuados. Cerca de un 70% de las epilepsias en niños tiene una buena respuesta a tratamiento médico o remisión espontánea y buen pronóstico en el largo plazo; se agrupan aquí las formas idiopáticas ya sea generalizadas como focales. Un grupo menor, pero no menos importante, es refractario a fármacos antiepilépticos, destacando las Encefalopatías Epilépticas que implican un mal pronóstico neurológico y un grupo de pacientes refractarios que serán candidatos a otras alternativas de tratamiento, como cirugía de la Epilepsia. Se revisan los principales conceptos que subyacen a la actual clasificación de Síndromes Electroclínicos y Epilepsias de ILAE y las características de algunos síndromes electro-clínicos atendiendo a su frecuencia, relevancia de un diagnóstico preciso y aportes recientes de significación

  10. An empirical assessment of the focal species hypothesis.

    Science.gov (United States)

    Lindenmayer, D B; Lane, P W; Westgate, M J; Crane, M; Michael, D; Okada, S; Barton, P S

    2014-12-01

    Biodiversity surrogates and indicators are commonly used in conservation management. The focal species approach (FSA) is one method for identifying biodiversity surrogates, and it is underpinned by the hypothesis that management aimed at a particular focal species will confer protection on co-occurring species. This concept has been the subject of much debate, in part because the validity of the FSA has not been subject to detailed empirical assessment of the extent to which a given focal species actually co-occurs with other species in an assemblage. To address this knowledge gap, we used large-scale, long-term data sets of temperate woodland birds to select focal species associated with threatening processes such as habitat isolation and loss of key vegetation attributes. We quantified co-occurrence patterns among focal species, species in the wider bird assemblage, and species of conservation concern. Some, but not all, focal species were associated with high levels of species richness. One of our selected focal species was negatively associated with the occurrence of other species (i.e., it was an antisurrogate)-a previously undescribed property of nominated focal species. Furthermore, combinations of focal species were not associated with substantially elevated levels of bird species richness, relative to levels associated with individual species. Our results suggest that although there is some merit to the underpinning concept of the FSA, there is also a need to ensure that actions are sufficiently flexible because management tightly focused on a given focal species may not benefit some other species, including species of conservation concern, such of which might not occur in species-rich assemblages. © 2014 Society for Conservation Biology.

  11. [Sotos syndrome associated with focal dystonia].

    Science.gov (United States)

    Bravo, M; Chacón, J; Bautista, E; Pérez-Camacho, I; Trujillo, A; Grande, M A

    Sotos syndrome is a form of infantile gigantism characterized by excessive body size from the time of birth, particular facies, acromegalic changes and signs of non-progressive cerebral involvement. The etiology is unknown. Diagnosis is based on somatometric data and the particular phenotype traits. Biochemical and endocrine studies are normal. Torticollis is a focal dystonia and therefore more common in adults. A 20 year old woman with macrosomic features since birth presented with: weight 104 kg, height 182 cm; prognathism, hypertelorism, a broad over hanging forehead with a high hair line; large ears, hands and feet; torticollis towards the right with elevation and anteroversion of the right shoulder which caused symptomatic scoliosis. She was bradypsychic and rather slow in speech. The complementary tests done (cerebral and cervical CT and MR, bone gammography, evoked potentials, EMG-ENG, sural nerve biopsy, biopsy of skin and muscle, EEG and hormone and biochemistry studies) were normal. The torticollis was treated with botulinus toxin and improved considerably, as did the scoliosis. To date, dystonia has not been described in association with Sotos syndrome. This may be a causal association, or even perhaps hereditary, since the patient's mother had dystonia (in the form of blepharospasm).

  12. Depression in focal, segmental and generalized dystonia.

    Science.gov (United States)

    Lewis, L; Butler, A; Jahanshahi, M

    2008-11-01

    Dystonia causes body disfigurement in the majority of those affected. Our aim was to test the hypothesis that low self-esteem resulting from the sense of disfigurement is an important component of self-reported depression in focal, segmental and generalized dystonia. Questionnaires to assess self-reported depression, self-esteem, body concept, disfigurement, disability and quality of life were completed by 329 community based dystonia patients. Moderate to severe depression was reported by 30 %. Self-reported depression had a strong somatic component, but patients also showed a specific concern with self-image. Extent of dystonia, body parts affected and marital status influenced self-reported depression in dystonia. Self esteem, body concept, disfigurement and quality of life emerged as factors which accounted for the variance of self-reported depression in dystonia. These results suggest that in dystonia, disfigurement, negative body concept, low self-esteem, and the impact of the disease on quality of life make important contributions to depression. However, longitudinal followup is required to firmly establish the direction of causality between depression and these psychosocial variables in dystonia.

  13. Visual agnosia and focal brain injury.

    Science.gov (United States)

    Martinaud, O

    Visual agnosia encompasses all disorders of visual recognition within a selective visual modality not due to an impairment of elementary visual processing or other cognitive deficit. Based on a sequential dichotomy between the perceptual and memory systems, two different categories of visual object agnosia are usually considered: 'apperceptive agnosia' and 'associative agnosia'. Impaired visual recognition within a single category of stimuli is also reported in: (i) visual object agnosia of the ventral pathway, such as prosopagnosia (for faces), pure alexia (for words), or topographagnosia (for landmarks); (ii) visual spatial agnosia of the dorsal pathway, such as cerebral akinetopsia (for movement), or orientation agnosia (for the placement of objects in space). Focal brain injuries provide a unique opportunity to better understand regional brain function, particularly with the use of effective statistical approaches such as voxel-based lesion-symptom mapping (VLSM). The aim of the present work was twofold: (i) to review the various agnosia categories according to the traditional visual dual-pathway model; and (ii) to better assess the anatomical network underlying visual recognition through lesion-mapping studies correlating neuroanatomical and clinical outcomes. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  14. Nonhuman primate models of focal cerebral ischemia

    Directory of Open Access Journals (Sweden)

    Jingjing Fan

    2017-01-01

    Full Text Available Rodents have been widely used in the production of cerebral ischemia models. However, successful therapies have been proven on experimental rodent stroke model, and they have often failed to be effective when tested clinically. Therefore, nonhuman primates were recommended as the ideal alternatives, owing to their similarities with the human cerebrovascular system, brain metabolism, grey to white matter ratio and even their rich behavioral repertoire. The present review is a thorough summary of ten methods that establish nonhuman primate models of focal cerebral ischemia; electrocoagulation, endothelin-1-induced occlusion, microvascular clip occlusion, autologous blood clot embolization, balloon inflation, microcatheter embolization, coil embolization, surgical suture embolization, suture, and photochemical induction methods. This review addresses the advantages and disadvantages of each method, as well as precautions for each model, compared nonhuman primates with rodents, different species of nonhuman primates and different modeling methods. Finally it discusses various factors that need to be considered when modelling and the method of evaluation after modelling. These are critical for understanding their respective strengths and weaknesses and underlie the selection of the optimum model.

  15. Aportes para una vida saludable. Proceso socioeducativo con estudiantes de primer ingreso, Universidad Nacional

    OpenAIRE

    Gonzalez-Soto, L.; Orozco-Morales, A.R.

    2017-01-01

    Propósito: Exponer la experiencia de medir en algún grado el impacto social de un proceso socioeducativo anual, desarrollado con 800 estudiantes de primer ingreso provenientes de diversos lugares del país, con limitadas condiciones socioeconómica y quienes son beneficiarios de beca para sus estudios. El proceso consistió en establecer 4 o 5 eventos anuales y trabajar con metodologías lúdicas temas alusivos a estilos de vida saludables. Material y método: Se aplicó la técnica de grupo focal al...

  16. Evaluation of Hemodynamics in Focal Steatosis and Focal Spared Lesion of the Liver Using Contrast-Enhanced Ultrasonography with Sonazoid

    International Nuclear Information System (INIS)

    Shiozawa, K.; Watanabe, M.; Ikehara, T.; Kogame, M.; Shinohara, M.; Shinohara, M.; Ishii, K.; Igarashi, Y.; Sumino, Y.; Shiozawa, K.; Makino, H.

    2014-01-01

    We aim to investigate the hemodynamics in focal steatosis and focal spared lesion of the liver using contrast-enhanced ultrasonography (CEUS) with Sonazoid. The subjects were 47 patients with focal steatosis and focal spared lesion. We evaluated enhancement patterns (hyper enhancement, iso enhancement, and hypo enhancement) in the vascular phase and the presence or absence of a hypoechoic area in the post vascular phase for these lesions using CEUS. Of the 24 patients with focal steatosis, the enhancement pattern was iso enhancement in 19 and hypo enhancement in 5. Hypoechoic areas were noted in the post vascular phase in 3 patients. Of the 23 patients with focal spared lesions, the enhancement pattern was iso enhancement in 18 and hyper enhancement in 5. No hypoechoic areas were noted in the post vascular phase in any patient. The hemodynamics in focal steatosis and focal spared lesions in non diffuse fatty liver can be observed using low-invasive procedures in real-time by CEUS. It was suggested that differences in the dynamics of enhancement in the vascular phase of CEUS were influenced by the fat deposits in the target lesion, the surrounding liver parenchyma, and the third inflow.

  17. Giochiamo con i robot

    Directory of Open Access Journals (Sweden)

    Andrea Bonarini

    2009-01-01

    Full Text Available "Giochiamo con i robot" e' un laboratorio interattivo per grandi e piccini realizzato per l'edizione 2007 del Festival della Scienza di Genova. Lungo un percorso che va dalla telerobotica alla robotica evolutiva, il laboratorio sviluppa il tema di dare intelligenza ai robot. Questo percorso, le cui tappe sono le varie installazioni, si conclude nella "bottega" dove e' possibile costruire e programmare i propri robot o smontare e modificare quelli esposti durante il percorso didattico. I visitatori sono coinvolti in attivita' ludiche grazie alle quali possonoentrare in contatto con alcune delle idee potenti della robotica,

  18. disegnare con ... Alberto Pratelli

    Directory of Open Access Journals (Sweden)

    Roberto Mingucci

    2017-12-01

    Full Text Available Con questa breve intervista ad Alberto Pratelli, (non a caso scelto per aprire questa nuova rubrica intendia-mo inaugurare un dialogo con personalità significati-ve del Disegno di Architettura, che consenta riflessioni dedicate alle sue varie dimensioni, oggi più che mai da approfondire. La suggestione a farlo, viene da un’idea di Pablo Rodri-guez Navarro ed abbiamo quindi pensato di avviarla proprio in questo numero, che Pablo ha accettato di curare su un tema a lui particolarmente caro.

  19. Conversando con Oriol Bohigas

    OpenAIRE

    Redondo Domínguez, Ernesto; Moya Sala, Joaquim

    2015-01-01

    [EN] Interview with Oriol Bohigas [ES] Entrevista con Oriol Bohigas Redondo Domínguez, E.; Moya Sala, J. (2015). Conversando con… Oriol Bohigas. EGA. Revista de Expresión Gráfica Arquitectónica. 20(26):22-35. doi:10.4995/ega.2015.4061 22 35 20 26

  20. DR Con o:

    African Journals Online (AJOL)

    which could fall under the Ugandan influence. The con-. flict in the ..... The Congolese people and international community within SADC, the AU ..... ments and make peace among themselves. However, one ... friends overnight.There is a great ...

  1. Focal Atrichia: A Diagnostic Clue in Female Pattern Hair Loss.

    Science.gov (United States)

    Olsen, Elise A; Whiting, David A

    2017-10-07

    Focal atrichia is a common clinical finding in female pattern hair loss whose specificity and histologic findings need further clarification. To determine the frequency of focal atrichia in various types of hair loss and its histologic characteristics in female pattern hair loss. Part 1: Review of 250 consecutive female patients seen with hair loss for the presence of focal atrichia and Part 2: paired biopsies of haired areas vs focal atrichia in 18 subjects with female pattern hair loss RESULTS: Focal atrichia was seen in 46/104 (44%) of women with female pattern hair loss, including 67% of late onset vs 15% of early onset, compared to 3/146 (2%) of those with other hair disorders Biopsy findings of focal atrichia in female pattern hair loss showed primarily a more progressive miniaturization process than that of haired areas of the scalp. Some women with female pattern hair loss may have had concomitant chronic telogen effluvium CONCLUSIONS: When present, focal atrichia is a clinical clue to the diagnosis of female pattern hair loss, particularly late onset subtype. Copyright © 2017. Published by Elsevier Inc.

  2. The semiology of febrile seizures: Focal features are frequent.

    Science.gov (United States)

    Takasu, Michihiko; Kubota, Tetsuo; Tsuji, Takeshi; Kurahashi, Hirokazu; Numoto, Shingo; Watanabe, Kazuyoshi; Okumura, Akihisa

    2017-08-01

    To clarify the semiology of febrile seizures (FS) and to determine the frequency of FS with symptoms suggestive of focal onset. FS symptoms in children were reported within 24h of seizure onset by the parents using a structured questionnaire consisting principally of closed-ended questions. We focused on events at seizure commencement, including changes in behavior and facial expression, and ocular and oral symptoms. We also investigated the autonomic and motor symptoms developing during seizures. The presence or absence of focal and limbic features was determined for each patient. The associations of certain focal and limbic features with patient characteristics were assessed. Information was obtained on FS in 106 children. Various events were recorded at seizure commencement. Behavioral changes were observed in 35 children, changes in facial expression in 53, ocular symptoms in 78, and oral symptoms in 90. In terms of events during seizures, autonomic symptoms were recognized in 78, and convulsive motor symptoms were recognized in 68 children. Focal features were evident in 81 children; 38 children had two or more such features. Limbic features were observed in 44 children, 9 of whom had two or more such features. There was no significant relationship between any patient characteristic and the numbers of focal or limbic features. The semiology of FS varied widely among children, and symptoms suggestive of focal onset were frequent. FS of focal onset may be more common than is generally thought. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. The dispersion-focalization theory of sound systems

    Science.gov (United States)

    Schwartz, Jean-Luc; Abry, Christian; Boë, Louis-Jean; Vallée, Nathalie; Ménard, Lucie

    2005-04-01

    The Dispersion-Focalization Theory states that sound systems in human languages are shaped by two major perceptual constraints: dispersion driving auditory contrast towards maximal or sufficient values [B. Lindblom, J. Phonetics 18, 135-152 (1990)] and focalization driving auditory spectra towards patterns with close neighboring formants. Dispersion is computed from the sum of the inverse squared inter-spectra distances in the (F1, F2, F3, F4) space, using a non-linear process based on the 3.5 Bark critical distance to estimate F2'. Focalization is based on the idea that close neighboring formants produce vowel spectra with marked peaks, easier to process and memorize in the auditory system. Evidence for increased stability of focal vowels in short-term memory was provided in a discrimination experiment on adult French subjects [J. L. Schwartz and P. Escudier, Speech Comm. 8, 235-259 (1989)]. A reanalysis of infant discrimination data shows that focalization could well be the responsible for recurrent discrimination asymmetries [J. L. Schwartz et al., Speech Comm. (in press)]. Recent data about children vowel production indicate that focalization seems to be part of the perceptual templates driving speech development. The Dispersion-Focalization Theory produces valid predictions for both vowel and consonant systems, in relation with available databases of human languages inventories.

  4. Widespread EEG changes precede focal seizures.

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    Piero Perucca

    Full Text Available The process by which the brain transitions into an epileptic seizure is unknown. In this study, we investigated whether the transition to seizure is associated with changes in brain dynamics detectable in the wideband EEG, and whether differences exist across underlying pathologies. Depth electrode ictal EEG recordings from 40 consecutive patients with pharmacoresistant lesional focal epilepsy were low-pass filtered at 500 Hz and sampled at 2,000 Hz. Predefined EEG sections were selected immediately before (immediate preictal, and 30 seconds before the earliest EEG sign suggestive of seizure activity (baseline. Spectral analysis, visual inspection and discrete wavelet transform were used to detect standard (delta, theta, alpha, beta and gamma and high-frequency bands (ripples and fast ripples. At the group level, each EEG frequency band activity increased significantly from baseline to the immediate preictal section, mostly in a progressive manner and independently of any modification in the state of vigilance. Preictal increases in each frequency band activity were widespread, being observed in the seizure-onset zone and lesional tissue, as well as in remote regions. These changes occurred in all the investigated pathologies (mesial temporal atrophy/sclerosis, local/regional cortical atrophy, and malformations of cortical development, but were more pronounced in mesial temporal atrophy/sclerosis. Our findings indicate that a brain state change with distinctive features, in the form of unidirectional changes across the entire EEG bandwidth, occurs immediately prior to seizure onset. We postulate that these changes might reflect a facilitating state of the brain which enables a susceptible region to generate seizures.

  5. Focal Segmental Glomerulosclerosis: A Single Center Experience

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    Yavuz Ayar

    2016-09-01

    Full Text Available Aim: Focal segmental glomerulosclerosis (FSGS is one of the most common glomerulonephritis (GNP worldwide. Despite treatment, it may progress to end-stage renal disease. In the present study, we compared clinical and histopathological data on FSGS with primary and secondary GNP retrospectively. Methods: We retrospectively analyzed data on clinical and laboratory findings, treatment response, and risk factors associated with mortality in patients, who had been diagnosed with FSGS and other GNP via renal biopsy between January 2009 and December 2014. The average follow-up time was 22 (8-76 months. Results: FSGS and primary GNP were more frequently seen in males than in females (55.9% vs. 65.3%, p=0.033. Nephrotic syndrome was more common in patients with FSGS (41.2% and primary GNP (57.7%, while chronic renal disease was more frequent in patients with secondary GNP (35%. In FSGS, the complete remission rate was 54.4%. 63.2% of patients had continued to receive treatment. According to the biopsy findings, interstitial inflammation and fibrosis were observed in 100% and 98.5% of patients with FSGS, respectively (p=0.010 and p<0.001, respectively. Serum albumin level was found to be increased and proteinuria, total cholesterol, triglyceride, and LDL levels to be decreased after treatment (p<0.001. Serum creatinine levels and type of GNP (secondary GNP were detected to be 1.48 and 8.14 fold increased in mortality analysis, respectively. Conclusion: Renal biopsy is the gold standard for the diagnosis of glomerular diseases. Renal function at the time of diagnosis, follow-up and appropriate immunosuppressive therapy have effects on mortality and clinical progress in FSGS as is the case in all GNPs.

  6. Focal Length Affects Depicted Shape and Perception of Facial Images.

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    Vít Třebický

    Full Text Available Static photographs are currently the most often employed stimuli in research on social perception. The method of photograph acquisition might affect the depicted subject's facial appearance and thus also the impression of such stimuli. An important factor influencing the resulting photograph is focal length, as different focal lengths produce various levels of image distortion. Here we tested whether different focal lengths (50, 85, 105 mm affect depicted shape and perception of female and male faces. We collected three portrait photographs of 45 (22 females, 23 males participants under standardized conditions and camera setting varying only in the focal length. Subsequently, the three photographs from each individual were shown on screen in a randomized order using a 3-alternative forced-choice paradigm. The images were judged for attractiveness, dominance, and femininity/masculinity by 369 raters (193 females, 176 males. Facial width-to-height ratio (fWHR was measured from each photograph and overall facial shape was analysed employing geometric morphometric methods (GMM. Our results showed that photographs taken with 50 mm focal length were rated as significantly less feminine/masculine, attractive, and dominant compared to the images taken with longer focal lengths. Further, shorter focal lengths produced faces with smaller fWHR. Subsequent GMM revealed focal length significantly affected overall facial shape of the photographed subjects. Thus methodology of photograph acquisition, focal length in this case, can significantly affect results of studies using photographic stimuli perhaps due to different levels of perspective distortion that influence shapes and proportions of morphological traits.

  7. fertilizada con diferentes abonos

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    Jorge Alberto Elizondo-Salazar

    2007-01-01

    Full Text Available Producción y calidad de la biomasa de morera (Morus alba fertilizada con diferentes abonos. Se llevó a cabo un experimento en la Estación Experimental “Alfredo Volio Mata” de la Universidad de Costa Rica con el fi n de evaluar la aplicación de 150 kg de N/ha/año proveniente de dos abonos orgánicos: lombriabono y compostaje; y de un fertilizante químico, sobre la producción y calidad de la biomasa de morera. El periodo experimental comprendió un ciclo de 12 meses, iniciando en julio del 2003 y fi nalizando en julio del 2004. Se utilizó una plantación de morera de 12 años de establecida con una densidad de siembra de 27.777 plantas/ ha. Se empleó un diseño de bloques completos al azar con cuatro tratamientos: dos abonos orgánicos, nitrato de amonio (33,5% N y un control. Las plantas se podaron a 0,6 m sobre el nivel del suelo al inicio del ensayo. Durante el periodo experimental, las plantas fueron podadas consecutivamente cada 90 días. Las hojas y los tallos fueron separados y analizados para determinar el contenido de materia seca y proteína cruda. La producción de materia seca fue 23% superior y el contenido de proteína cruda fue signifi cativamente mayor con el nitrógeno químico, mientras que el contenido de materia seca fue menor. No se encontraron diferencias signifi cativas entre el tratamiento control y los tratamientos orgánicos.

  8. Client with epilepsy in a work Brazilian rehabilitation center Cliente com epilepsia em um centro de reabilitação profissional brasileiro

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    MARLEIDE DA MOTA GOMES

    2000-06-01

    Full Text Available INTRODUCTION: People with epilepsy (PWE may have problems in obtaining or maintaining regular employment because of restrictions related to their handicap, social prejudices and also high rates of unemployment of the population. The main aim of this pilot study was to know the vocational rehabilitation problems involving PWE sent to a vocational rehabilitation center (VRC in Rio de Janeiro. METHOD: Fifteen PWE were selected unbiased from those seen at the VCR. It was reviewed their records in the search of sociodemographic, health care, employment suitability and work rehabilitation data. RESULTS: Only one person was eligible for the training program, four were ineligible, six were temporarily ineligible, and the other four do not necessitate the rehabilitation, but as the majority, the better seizures control. CONCLUSIONS: The studied sample of selected PWE, but representative of the studied population, do not show any important successful in the vocational rehabilitation carried out at the VRC.INTRODUÇÃO: A pessoa com epilepsia (PCE pode ter problemas para obter ou manter emprego regular por conta de restrições relacionadas à sua deficiência, preconceitos sociais ou altas taxas de desemprego na população. O principal objetivo deste estudo piloto é o reconhecimento dos problemas de reabilitação profissional de PCE enviadas para um Centro de Reabilitação Profissional (CRP no Rio de Janeiro. MÉTODO: Quinze PCE foram selecionadas sem viés de um CRP. Foram revistos seus prontuários na procura de dados sociodemográficos, de cuidados de saúde, além de capacidade de emprego segundo a análise de função e infortunística. RESULTADOS: Apenas uma pessoa foi elegível para o programa de treinamento, quatro inelegíveis, seis temporariamente inelegíveis, e os outros quatro não necessitam da reabilitação profissional, mas como a maioria, o melhor controle das crises epilépticas. CONCLUSÕES: A amostra estudada e selecionada de PCE

  9. Lateralização das funções musicais na epilepsia parcial Asymmetry of musical functions in partial epilepsy

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    CLÉO MONTEIRO FRANÇA CORREIA

    1998-12-01

    Full Text Available Foram avaliados 14 pacientes destros com idade mediana de 30 anos, portadores de epilepsia parcial (Grupo Epiléptico e divididos em dois Grupos (Direito e Esquerdo, segundo a lateralização da atividade paroxística no eletrencefalograma interictal. Dos 14 pacientes, 42,8% (6/14 dos casos apresentaram foco à direita, enquanto os 57,2% (8/14 restantes apresentaram foco à esquerda. O Grupo Controle foi formado por 31 indivíduos destros com idade mediana de 30 anos e sem história de doença neurológica ou antecedente de crises epilépticas. Os indivíduos estudados, sem conhecimento musical, realizaram Testes de Habilidades Musicais que envolveram Ritmo Espontâneo, Percepção dos Parâmetros Musicais (timbre, duração, altura, intensidade e ritmo e Testes Gnósico-Práxicos (reconhecimento e reprodução de parâmetros musicais e organização e reprodução de movimentos corporais rítmicos. Concluímos que a presença do foco no hemisfério cerebral direito afeta o desempenho de funções de reconhecimento melódico, enquanto que nos casos com foco no hemisfério cerebral esquerdo, a reprodução e organização rítmicas estão mais comprometidas quando comparados ao Grupo Controle.Fourteen right handed patients with partial epilepsy (Epileptic Group and with a median age of 31 years were divided into two groups (Right and Left, according the laterality of paroxystic activity in the eletroencaphalogram. Of the 14 patients, 42.8% (6/14 presented a focus at the right side while the others 57.2% (8/14 presented a focus at the left. The Control Group consisted of 31 right handed individuals with a median age of 30 years and with no previous history of neurological disease or epileptic seizures. All the individuals had no musical skills. They carried out Music Abilities Tests including Spontaneous Rhythm, Elemental Music Functions Perception (tone color, duration, pitch, intensity and rhythm and Complex Strutures Tests (recognition and

  10. The design of LMJ focal spots for indirect drive experiments

    International Nuclear Information System (INIS)

    Le Garrec, B J; Sajer, J M

    2008-01-01

    LMJ is a 240 high power laser beam facility for achieving laser matter interaction experiments, high energy density science, including the demonstration of fusion ignition through Inertial Confinement. The Laser Integration Line (LIL) facility is currently a 4-beam prototype for LMJ. The intensity I 0 at the focal spot centre drives hydrodynamic and plasma instabilities and the intensity in the wings must be low to go through the laser entrance Hohlraum. A simple model has been developed to compute the LMJ focal spot. The model gives the intensity at the centre as a function of the focal spot area at 3% of the maximum

  11. Focal cemento-osseous dysplasia: review and a case report.

    Science.gov (United States)

    Salem, Y M Y; Osman, Y I; Norval, E J G

    2010-10-01

    Focal cemento-osseous dysplasia is a benign fibro-osseous condition that can be seen in dentate and edentulous patients. It is an asymptomatic lesion and needs no treatment; however follow-up is essential due to the possibility that focal cemento-osseous dysplasia can progress to a condition called florid osseous dysplasia that involves multiple sites. A case report is presented here, along with a review of the differential diagnoses considered in order to reach a final diagnosis of focal cemento-osseous dysplasia.

  12. Benign focal liver lesions: discrimination from malignant mimickers.

    Science.gov (United States)

    Alobaidi, Mohammad; Shirkhoda, Ali

    2004-01-01

    Focal lesions of the liver often have various imaging characteristics which may be interpreted as either benign or malignant. Understanding the underlying pathophysiology of these liver lesions may lead to characteristic imaging manifestations, which direct the radiologist to the diagnosis. Benign lesions include congenital hepatic cyst, autosomal dominant polycystic disease, hemangioma, focal nodular hyperplasia (FNH), hepatic adenoma, inflammatory pseudotumor, peliosis hepatis, focal fatty infiltration, hamartoma, and infectious processes such as hepatic abscess, echinococcal cyst, and candidiasis. Characteristic imaging features, clinical symptoms, and treatment/prognosis will be discussed. Emphasis will be placed on key reliable features of each disease to develop a method of discriminating these lesions from other benign and malignant disorders.

  13. Dual-layer electrode-driven liquid crystal lens with electrically tunable focal length and focal plane

    Science.gov (United States)

    Zhang, Y. A.; Lin, C. F.; Lin, J. P.; Zeng, X. Y.; Yan, Q.; Zhou, X. T.; Guo, T. L.

    2018-04-01

    Electric-field-driven liquid crystal (ELC) lens with tunable focal length and their depth of field has been extensively applied in 3D display and imaging systems. In this work, a dual-layer electrode-driven liquid crystal (DELC) lens with electrically tunable focal length and controllable focal plane is demonstrated. ITO-SiO2-AZO electrodes with the dual-layer staggered structure on the top substrate are used as driven electrodes within a LC cell, which permits the establishment of an alternative controllability. The focal length of the DELC lens can be adjusted from 1.41 cm to 0.29 cm when the operating voltage changes from 15 V to 40 V. Furthermore, the focal plane of the DELC lens can selectively move by changing the driving method of the applied voltage to the next driven electrodes. This work demonstrates that the DELC lens has potential applications in imaging systems because of electrically tunable focal length and controllable focal plane.

  14. La salud en personas con discapacidad intelectual en España: estudio europeo POMONA-II

    Science.gov (United States)

    Martínez-Leal, Rafael; Salvador-Carulla, Luis; Gutiérrez-Colosía, Mencía Ruiz; Nadal, Margarida; Novell-Alsina, Ramón; Martorell, Almudena; González-Gordón, Rodrigo G.; Mérida-Gutiérrez, M. Reyes; Ángel, Silvia; Milagrosa-Tejonero, Luisa; Rodríguez, Alicia; García-Gutiérrez, Juan C.; Pérez-Vicente, Amado; García-Ibáñez, José; Aguilera-Inés, Francisco

    2011-01-01

    Introducción Estudios internacionales demuestran que existe un patrón diferenciado de salud y una disparidad en la atención sanitaria entre personas con discapacidad intelectual (DI) y población general. Objetivo Obtener datos sobre el estado de salud de las personas con DI y compararlos con datos de población general. Pacientes y métodos Se utilizó el conjunto de indicadores de salud P15 en una muestra de 111 sujetos con DI. Los datos de salud encontrados se compararon según el tipo de residencia de los sujetos y se utilizó la Encuesta Nacional de Salud 2006 para comparar estos datos con los de la población general. Resultados La muestra con DI presentó 25 veces más casos de epilepsia y el doble de obesidad. Un 20% presentó dolor bucal, y existió una alta presencia de problemas sensoriales, de movilidad y psicosis. Sin embargo, encontramos una baja presencia de patologías como la diabetes, la hipertensión, la osteoartritis y la osteoporosis. También presentaron una menor participación en programas de prevención y promoción de la salud, un mayor número de ingresos hospitalarios y un uso menor de los servicios de urgencia. Conclusiones El patrón de salud de las personas con DI difiere del de la población general, y éstas realizan un uso distinto de los servicios sanitarios. Es importante el desarrollo de programas de promoción de salud y de formación profesional específicamente diseñados para la atención de personas con DI, así como la implementación de encuestas de salud que incluyan datos sobre esta población. PMID:21948011

  15. Implantação estereotáxica de eletrodos profundos por ressonância magnética para cirurgia de epilepsia MRI-guided stereotactic implantation of depth electrodes in epilepsy surgery

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    MURILO S. MENESES

    1999-09-01

    Full Text Available Apresentamos o caso de uma paciente com epilepsia refratária ao tratamento medicamentoso e submetida à monitorização em vídeo-eletrencefalografia por eletrodos de profundidade intracerebrais. A história, o exame clínico, a ressonância magnética (RM, a vídeo-eletrencefalografia e o estudo neuropsicológico não foram suficientes para a determinação da área cerebral de origem das crises convulsivas. Eletrodos de profundidade intracerebrais colocados por estereotaxia guiada por RM possibilitaram o registro de forma muito clara da atividade epileptiforme, determinando com precisão a área cerebral epileptogênica a ser removida por cirurgia. Após lobectomia temporal anterior direita com amígdalo-hipocampectomia realizada há três meses, a paciente permanece sem crises convulsivas. Segundo informações obtidas durante o último Congresso da Liga Brasileira de Epilepsia, esta é a primeira cirurgia estereotáxica para colocação de eletrodos de profundidade intracerebrais em epilepsia no Brasil.We present the case of a 40-year-old woman with refractory epilepsy since aged 18, who was submitted to video-EEG monitoring with intracerebral depth electrodes. The clinical history and examination, magnetic resonance image (MRI, video-EEG and neuropsychological study did not allow the determination of the cerebral onset of epileptic seizures. Depth electrodes inserted by MRI-guided stereotaxis allowed the recording of the epileptic activity and thus showed quite accurately the area of the brain to be surgically resected. She underwent a right anterior temporal lobectomy with amygdalohippocampectomy. The immediate postoperative period was uneventful and she is without epileptic seizures after three months of follow-up. The average pre-operative free-seizure period was two weeks. To our knowledge, this is the first stereotactic surgery for insertion of depth intracerebral electrodes in epilepsy in Brazil.

  16. DEPDC5 takes a second hit in familial focal epilepsy.

    Science.gov (United States)

    Anderson, Matthew P

    2018-04-30

    Loss-of-function mutations in a single allele of the gene encoding DEP domain-containing 5 protein (DEPDC5) are commonly linked to familial focal epilepsy with variable foci; however, a subset of patients presents with focal cortical dysplasia that is proposed to result from a second-hit somatic mutation. In this issue of the JCI, Ribierre and colleagues provide several lines of evidence to support second-hit DEPDC5 mutations in this disorder. Moreover, the authors use in vivo, in utero electroporation combined with CRISPR-Cas9 technology to generate a murine model of the disease that recapitulates human manifestations, including cortical dysplasia-like changes, focal seizures, and sudden unexpected death. This study provides important insights into familial focal epilepsy and provides a preclinical model for evaluating potential therapies.

  17. Managing focal fields of vector beams with multiple polarization singularities.

    Science.gov (United States)

    Han, Lei; Liu, Sheng; Li, Peng; Zhang, Yi; Cheng, Huachao; Gan, Xuetao; Zhao, Jianlin

    2016-11-10

    We explore the tight focusing behavior of vector beams with multiple polarization singularities, and analyze the influences of the number, position, and topological charge of the singularities on the focal fields. It is found that the ellipticity of the local polarization states at the focal plane could be determined by the spatial distribution of the polarization singularities of the vector beam. When the spatial location and topological charge of singularities have even-fold rotation symmetry, the transverse fields at the focal plane are locally linearly polarized. Otherwise, the polarization state becomes a locally hybrid one. By appropriately arranging the distribution of the polarization singularities in the vector beam, the polarization distributions of the focal fields could be altered while the intensity maintains unchanged.

  18. Focal myositis of lower extremity responsive to botulinum A toxin.

    Science.gov (United States)

    Mitrovic, Josko; Prka, Zeljko; Zic, Rado; Marusic, Srecko; Morovic-Vergles, Jadranka

    2014-01-01

    Focal myositis is a rare, mostly benign disease (pseudotumor) of skeletal muscle, histopathologically characterized by interstitial myositis and tumorous enlargement of a single muscle. The etiology of focal myositis remains unknown; however, localized myopathy has been postulated to be caused by denervation lesions. This case report describes a patient that presented with clinical, laboratory, electromyoneurography, and magnetic resonance imaging features of focal myositis complicated with intervertebral disk protrusion in the lumbosacral spine affected with radicular distress. In most cases, focal myositic lesions show spontaneous regression, relapses are rare, and long-term prognosis is good. There is a wide spectrum of therapeutic options, from no therapy at all through nonsteroidal antirheumatics and glucocorticoids to radiotherapy, surgical excision, and immunosuppressants. In the patient presented, treatment with glucocorticoids, methotrexate, and surgical excision failed to produce satisfactory results. Clinical improvement, pain relief, and reduction in lower leg volume were only achieved by local infiltration of botulinum A toxin.

  19. Mechanical design and analysis of focal plate for gravity deformation

    Science.gov (United States)

    Wang, Jianping; Chu, Jiaru; Hu, Hongzhuan; Li, Kexuan; Zhou, Zengxiang

    2014-07-01

    The surface accuracy of astronomical telescope focal plate is a key indicator to precision stellar observation. To conduct accurate deformation measurement for focal plate in different status, a 6-DOF hexapod platform was used for attitude adjustment. For the small adjustment range of a classic 6-DOF hexapod platform, an improved structural arrangement method was proposed in the paper to achieve ultimate adjustment of the focal plate in horizontal and vertical direction. To validate the feasibility of this method, an angle change model which used ball hinge was set up for the movement and base plate. Simulation results in MATLAB suggested that the ball hinge angle change of movement and base plate is within the range of the limiting angle in the process of the platform plate adjusting to ultimate attitude. The proposed method has some guiding significance for accurate surface measurement of focal plate.

  20. FOCAL CORTICAL DYSPLASIAS: CLINICAL AND ELECTRO-NEUROIMAGING CHARACTERISTICS

    Directory of Open Access Journals (Sweden)

    K. Yu. Mukhin

    2016-01-01

    Full Text Available In spite of a notable advance made in epileptology, resistant epilepsies account for approximately 30 % of all forms of epilepsy particularly in patients with focal seizures. One of the main causes of therapy-resistant focal epilepsies is focal cortical dysplasias (FCD. This term was first introduced by D. Taylor et al. in 1971. FCD belongs to abnormal cortical development. Among all abnormalities of cortical development, FCD in surgically treated children amounts to 75 %. FCD is the most common cause of resistant epilepsy in children and the most frequent reason for diagnosing cryptogenic focal epilepsy with intractable seizures. The author gives a detailed literature review dedicated to FCD as a cause of resistant epilepsy, including the classification and histologic characteristics of FCD, its clinical manifestations and prognosis, and approaches to medical and surgical treatments. 

  1. Electrocorticographic discharge patterns in glioneuronal tumors and focal cortical dysplasia

    NARCIS (Netherlands)

    Ferrier, Cyrille H.; Aronica, Eleanora; Leijten, Frans S. S.; Spliet, Wim G. M.; van Huffelen, Alexander C.; van Rijen, Peter C.; Binnie, Colin D.

    2006-01-01

    PURPOSE: To determine whether highly epileptiform electrocorticographical discharge patterns occur in patients with glioneuronal tumors (GNTs) and focal cortical dysplasia (FCD) and whether specific histopathological features are related to such patterns. METHODS: The series consists of operated

  2. pacientes con falla cardiaca

    Directory of Open Access Journals (Sweden)

    Diana Marcela Achury Saldaña

    2007-01-01

    Full Text Available Objetivo: determinar la adherencia al tratamiento de pacientes con falla cardiaca hospitalizados, al aplicar un plan educativo quefomenta el autocuidado.Método: estudio cuasiexperimental (entrevistas enfermera-paciente realizado entre diciembre de 2004 y mayo de 2006, con unamuestra de 50 pacientes seleccionados por conveniencia. Se diseñó un instrumento para evaluar los comportamientos de los pacientes,con base en algunos resultados de la adherencia y sus respectivos indicadores de la taxonomía NOC (Nursing out comes classification. Laadherencia al tratamiento fue medida en dos momentos: el primero durante la hospitalización, seguido de la aplicación del plan educativoantes del alta, que proporcionaba información en el manejo de su enfermedad desde una dimensión física, psicológica y social quepromueve el autocuidado; y el segundo un mes después del alta en su domicilio.Resultados: diferencias estadísticamente significativas (P=0,0001 que demuestran cómo mediante la capacitación al paciente enel manejo de su tratamiento farmacológico y no farmacológico, el establecimiento de una sana relación entre el profesional de enfermeríay el paciente, y la participación de la familia, se logra una total adherencia al tratamiento.Conclusiones: para lograr una adherencia total del paciente con falla cardiaca al tratamiento es necesario un proceso educativo y unseguimiento continuo y personalizado que motive permanentemente al paciente y se le reconozca el papel protagónico en su cuidado y manejo de la enfermedad.

  3. Adult-onset Rasmussen encephalitis associated with focal cortical dysplasia.

    Science.gov (United States)

    Hohenbichler, Katharina; Lelotte, Julie; Lhommel, Renaud; Tahry, Riëm El; Vrielynck, Pascal; Santos, Susana Ferrao

    2017-12-01

    Rasmussen encephalitis is a rare, devastating condition, typically presenting in childhood. Cases of adult-onset Rasmussen have also been described, but the clinical picture is less defined, rendering final diagnosis difficult. We present a case of adult-onset Rasmussen encephalitis with dual pathology, associated with focal cortical dysplasia and encephalitis. We interpreted the Rasmussen encephalitis to be caused by severe and continuous epileptic activity due to focal cortical dysplasia. The best therapeutic approach for such cases remains unclear.

  4. Focal plane for the next generation of earth observation instruments

    Science.gov (United States)

    Pranyies, P.; Toubhans, I.; Badoil, B.; Tanguy, F.; Descours, Francis

    2017-09-01

    Sodern is the French focal plane provider for Earth Observation (EO) satellites. Since the 1980's, Sodern has played an active role first in the SPOT program. Within the two-spacecraft constellation Pleiades 1A/1B over the next years, Sodern introduced advanced technologies as Silicon Carbide (SiC) focal plane structure and multispectral strip filters dedicated to multiple-lines detectors.

  5. Inverse-designed stretchable metalens with tunable focal distance

    Science.gov (United States)

    Callewaert, Francois; Velev, Vesselin; Jiang, Shizhou; Sahakian, Alan Varteres; Kumar, Prem; Aydin, Koray

    2018-02-01

    In this paper, we present an inverse-designed 3D-printed all-dielectric stretchable millimeter wave metalens with a tunable focal distance. A computational inverse-design method is used to design a flat metalens made of disconnected polymer building blocks with complex shapes, as opposed to conventional monolithic lenses. The proposed metalens provides better performance than a conventional Fresnel lens, using lesser amount of material and enabling larger focal distance tunability. The metalens is fabricated using a commercial 3D-printer and attached to a stretchable platform. Measurements and simulations show that the focal distance can be tuned by a factor of 4 with a stretching factor of only 75%, a nearly diffraction-limited focal spot, and with a 70% relative focusing efficiency, defined as the ratio between power focused in the focal spot and power going through the focal plane. The proposed platform can be extended for design and fabrication of multiple electromagnetic devices working from visible to microwave radiation depending on scaling of the devices.

  6. Thermomechanical architecture of the VIS focal plane for Euclid

    International Nuclear Information System (INIS)

    Martignac, Jerome; Carty, Michael; Tourette, Thierry; Bachet, Damien; Berthe, Michel; Augueres, Jean-Louis; Amiaux, Jerome; Fontignie, Jean; Horeau, Benoit; Renaud, Diana

    2014-01-01

    One of the main challenges for current and near future space experiments is the increase of focal plane complexity in terms of amount of pixels. In the frame work of the ESA Euclid mission to be launched in 2020, the Euclid Consortium is developing an extremely large and stable focal plane for the VIS instrument. CEA has developed the thermomechanical architecture of that Focal Plane taking into account all the very stringent performance and mission related requirements. The VIS Focal Plane Assembly integrates 36 CCDs (operated at 150 K) connected to their front end electronics (operated at 280 K) as to obtain one of the largest focal plane (0.6 billion pixels) ever built for space application after the GAIA one. The CCDs are CCD273 type specially designed and provided by the e2v company under ESA contract, front end electronics is studied and provided by MSSL. In this paper we first recall the specific requirements that have driven the overall architecture of the VIS-FPA and especially the solutions proposed to cope with the scientific needs of an extremely stable focal plane, both mechanically and thermally. The mechanical structure based on SiC material used for the cold sub assembly supporting the CCDs is detailed. We describe also the modular architecture concept that we have selected taking into account AIT-AIV and programmatic constraints. (authors)

  7. Blaschko Linear Enamel Defects - A Marker for Focal Dermal Hypoplasia: Case Report of Focal Dermal Hypoplasia

    Directory of Open Access Journals (Sweden)

    Stefan Gysin

    2015-05-01

    Full Text Available Focal dermal hypoplasia (FDH is a rare genetic skin disorder. The inheritance of FDH or Goltz-Gorlin syndrome is X-linked dominant and the disease is associated with a PORCN gene mutation. This gene plays a key role in the Wnt pathway, which has an impact on embryonic development. Every tissue derived from meso- and ectoderm can be affected. Patients suffer from cutaneous, ocular, osseous, oral and dental defects. The skin and dental alterations manifest along the Blaschko lines. We present a woman (born in 1962 suffering from FDH with congenital skin changes and Blaschko linear enamel defects. Typical symptoms (e.g. fat herniations, scoliosis, syndactyly, microphthalmia, caries and alopecia plus vertical grooving of all teeth gave a first indication. Molecular genetic testing confirmed the definitive diagnosis of FDH. We hypothesize that, in the context of typical skin changes, visible Blaschko lines on the teeth in the form of vertical grooves are almost pathognomonic for FDH.

  8. Epilepsia mioclônica progressiva: aspectos clínicos, poligráficos e histopatológicos de um caso Progressive myoclonic epilepsy: clinical, polygraphic and histopathological aspects. A case report

    Directory of Open Access Journals (Sweden)

    Wilson Luiz Sanvito

    1973-06-01

    Full Text Available É relatado um caso caracterizado clinicamente por crises mioclônicas, crises convulsivas do tipo grande mal e rebaixamento mental progressivo. O estudo histo-patológico revelou a presença de corpúsculos intracitoplasmáticos no sistema nervoso central, com as características dos corpúsculos de Lafora. São feitas considerações clínicas, poligráficas, histopatológicas e etiopatogênicas a propósito da epilepsia mioclônica progressiva.A case with myoclonic jerks, grand mal convulsions and progressive mental retardation is reported. The patient died after 4 years and 10 months of disease, and a sister began with similar simptomatology at this time. By histopathological study there were found intracitoplasmatic bodies in the cerebral cortex, basal ganglia, cerebelum and myocardium. Some considerations are made about clinical, polygraphic histological and etiopathogenic aspects.

  9. Seismicity, focal mechanisms, and stress distribution in the Tres Virgenes volcanic and geothermal region, Baja California Sur, Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Wong, Victor; Munguia, Luis [Centro de Investigacion Cientifica y de Educacion Superior de Ensenada (Mexico)

    2006-01-15

    In October 1993 we carried out a seismic monitoring in the Tres Virgenes volcanic region in order to record the background seismicity associated with the volcanic structures, the geothermal field and the tectonic features of the area. Hypocenters for 257 microearthquakes were located in the volcanic edifices and along the northwest right-lateral, strike-slip La Virgen fault. Focal depths range from close to the Earth surface to about 8 km. Shallow depths occur mainly in the volcanic edifices. Deeper seismic events occurred outside the volcanic area. The duration magnitudes of the located microearthquakes range between 1 and 3. The Vp/Vs ratio and the low-Q values estimated suggest heterogeneous material properties in the volcanic structures mainly toward the El Azufre fault and the El Aguajito Caldera, where hydrothermal activity has been reported. The P- and T-axes of focal mechanisms for 90 microearthquakes suggest that the region is under N-S compression and E-W extension, in agreement with the regional tectonic stress field of the NW-SE right-lateral strike-slip transform fault system of the Gulf of California. [Spanish] En octubre de 1993 se llevo a cabo un monitoreo sismico en la region volcanica Las Tres Virgenes con el proposito de registrar la actividad sismica asociada a las estructuras volcanicas, al campo geotermico y a la tectonica local. Se localizaron 257 microsismos con hipocentros en los edificios volcanicos y a lo largo de la falla de rumbo, lateral derecha conocida como falla La Virgen. La profundidad focal de los sismos varia desde los muy cercanos a la superficie de la Tierra hasta los 8 km. Las profundidades someras ocurren principalmente en los edificios volcanicos. Los sismos mas profundos ocurren fuera del area volcanica. La magnitud de duracion de los microsismos localizados varia entre 1 y 3. La razon Vp/Vs y los valores bajos de Q que se estimaron en la zona sugieren un material con propiedades heterogeneas bajo las estructuras

  10. Cementos con cenizas volantes

    Directory of Open Access Journals (Sweden)

    Ossa M., Mauricio

    1984-03-01

    additions of 20 and 30% .

    Casi la generalidad de los estudios realizados sobre cementos con adición de cenizas volantes se refieren a sus características y comportamiento en pastas, morteros y hormigones, siempre en relación con aquéllos del cemento portland. Esta vez, se desarrolló un trabajo experimental orientado a relacionar entre sí los cementos con adiciones de cenizas volantes y de puzolana natural. Para ello se fabricaron a escala de laboratorio cementos de ambos tipos, empleando como materias primas comunes clinker y yeso y, como variables, diferentes porcentajes de las dos adiciones, que cumplieron previamente los requisitos normalizados en cuanto a sus actividades puzolánicas. La calidad de los cementos fabricados resultó adecuada y concordante con la del cemento portland-puzolánico obtenido a escala industrial con los mismos clinker, yeso y puzolana natural de este estudio. Posteriormente, se determinaron las características de los cementos experimentales y se confeccionaron morteros normales para la realización de ensayos físicos y mecánicos. Los resultados de ensayos indicaron que los cementos con adición de cenizas volantes (CCV requieren menos agua para consistencia normal, presentan tiempos de fraguado mayores y expansiones en autoclave menores que los cementos con adición de puzolana (CP. Los calores de hidratación a 7 y 28 días de edad fueron aproximadamente similares para ambos tipos de cemento. En morteros normales, los cementos CCV mostraron menor retracción de secado, mayor retentividad y mayor fluidez (para igual cantidad de agua que los cementos CP. En los ensayos de exudación se observó que ésta depende más de la finura que el tipo de adición. Finalmente, los ensayos mecánicos señalaron que las resistencias a compresión y flexotracción de los morteros con cementos CCV son menores a edades inferiores que 14 días (del orden de 5 a 10% a un día de edad, pero que a partir de entonces pasan a ser mayores que las de

  11. Epilepsias com focos projetados na linha média: estudo com EEG quantitativo e topográfico (mapeamento cerebral

    Directory of Open Access Journals (Sweden)

    ANGHINAH RENATO

    1998-01-01

    Full Text Available Estudamos com EEG quantitativo e topográfico (mapeamento cerebral quatro pacientes com exames pregressos de EEG convencional mostrando foco de linha média. O estudo quantitativo revelou-se mais preciso na definição do foco, localizando o seu hemisfério de origem e definindo a atividade focal como parassagital. Estes achados deverão ser validados em estudos futuros com amostragem maior.

  12. competencia con China

    Directory of Open Access Journals (Sweden)

    Elena de la Paz Hernández Águila

    2007-01-01

    Full Text Available El artículo ofrece un diagnóstico del desempeño de la industria mexicana del calzado desde la década de los ochenta hasta la actualidad. Analiza la problemática que ha enfrentado esta rama industrial a partir del proceso de apertura comercial y de la competencia en su mercado interno con productos provenientes de países asiáticos, particularmente China. Problematiza al respecto los retos y las perspectivas que a mediano plazo enfrentará este sector empresarial y sobre las posibilidades de competir en el mercado globalizado.

  13. Construir con Madera

    OpenAIRE

    Olabe-Velasco, F. (Fermín); Val-Hernández, Y. (Yolanda); Varela-de-la-Cruz, P. (Perla); Cabrero-Ballarín, J.M. (José Manuel)

    2010-01-01

    Guía divulgativa ‘Construir con madera’, elaborada por la Cátedra Madera de la Universidad de Navarra y el Gobierno de Navarra. La publicación pretende explicar de forma sencilla los beneficios y posibilidades de este material en la construcción, tanto en lo que respecta a su resistencia, comportamiento frente al fuego, durabilidad, capacidad de aislamiento, propiedades acústicas, estética, respeto al medio ambiente y sostenibilidad como fuente de energía. A modo de ejemplo, en la ...

  14. Entrevista con Giovanni Levi

    Directory of Open Access Journals (Sweden)

    Monica Oliveira

    2017-06-01

    Full Text Available En esta entrevista, Giovanni Levi - como un conocedor del tema de Familia - realiza una importante evaluación sobre el actual estado de las investigaciones realizadas en el Brasil y em el exterior. Con estilo franco, agudo y lucido critica las visiones tradicionales y sus ilusiones ypropone nuevos conceptos y métodos. La historia de la familia debería ceder espacio para el estudio de las redes relacionales o de los mundos relacionales. De la misma forma, la historia cuantitativa debería abrir espacio para el estudio de las cualidades. Ya con relación a la historia de las elites, tan estudiada y reproducida en una diversidad de trabajos, que deberíase mirar en otra perspectiva. Es decir, no mirar a las reglas sociales predeterminadas, sino a los desvíos y a las variaciones. Levi defiende que los historiadores deben trascender a los documentos que se encuentran fácilmente y que pueden fortalecer perspectivas deformadas y esequilibradas de la sociedad. Para él, los historiadores deben esforzarse por estudiar a aquellos grupos que dejaron pocos rastros documentales. En ese esfuerzo existiría una nueva mirada sobre la historia de la familia.

  15. Entrevista con Patricia Ariza

    Directory of Open Access Journals (Sweden)

    Esperanza Londoño La Rotta

    2017-01-01

    Full Text Available Pensamiento, Palabra y Obra entrevista a una artista, feminista y activista política, quien como mujer y artista ha permitido pensar el arte más allá de un simple espectáculo. Toda una vida dedicada al teatro y a darle voz, a través de sus obras, a víctimas del conflicto colombiano, defensora de derechos humanos; además de hacer evidente en su vida y a través de la plataforma “Artistas por la paz”, las múltiples relaciones que se pueden establecer entre el arte, la construcción de paz y la resolución de conflictos. Hablamos en su casa, en medio del calor de la bienvenida con Patricia Ariza, directora del festival alternativo de teatro, de Mujeres en Escena y de la Corporación Colombiana de Teatro, entre otras muchas actividades que voluntariamente su espíritu libertario ha asumido. Esta entrevista se realizó antes del 2 de octubre, pero con la revisión de los acuerdos que propició el plebiscito ganado por una ínfima minoría por el no, sigue siendo vigente este planteamiento.

  16. CT findings of focal organizing pneumonia: correlation with pathologic findings

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yang Soo; Kim, Young Goo; Park, Un Sup [College of Medicine, Chungang University, Seoul (Korea, Republic of)

    1994-11-15

    To evaluate the CT findings of focal organizing pneumonia and to correlate them with pathologic findings to help differentiating from lung cancer. We evaluated radiologic and pathologic findings of five patients with solitary pulmonary nodule which were confirmed as focal organizing pneumonia pathologically. On CT scan, focal organizing pneumonia had irregular margin contacting the pleura in all five cases. The shape of the nodules were spherical to wedge or elliptical and the size from 3.5cm to 5.5cm(average 4.2 cm) in largest diameter. On postcontrast CT scan, all nodules showed enhancement and four cases showed central low density components. Two nodules contained air within the nodule. In four cases, pleural changes such as effusion and/or focal thickening were noted. No lymphadenopathy was found in all cases. Pathologically, the enhancing portion on CT showed findings of organizing pneumonia such as granulation tissue with fibroblast proliferation in alveolar space and interstitial thickening. The central low density areas on CT were due to ischemic necrosis, abscess and exudate, transudate and infiltration of foamy histiocyte. The possibility of focal organizing pneumonia should be considered when peripherally located solitary pulmonary nodule had enhancing component with no combined lymphadenopathy on CT scan.

  17. CT findings of focal organizing pneumonia: correlation with pathologic findings

    International Nuclear Information System (INIS)

    Kim, Yang Soo; Kim, Young Goo; Park, Un Sup

    1994-01-01

    To evaluate the CT findings of focal organizing pneumonia and to correlate them with pathologic findings to help differentiating from lung cancer. We evaluated radiologic and pathologic findings of five patients with solitary pulmonary nodule which were confirmed as focal organizing pneumonia pathologically. On CT scan, focal organizing pneumonia had irregular margin contacting the pleura in all five cases. The shape of the nodules were spherical to wedge or elliptical and the size from 3.5cm to 5.5cm(average 4.2 cm) in largest diameter. On postcontrast CT scan, all nodules showed enhancement and four cases showed central low density components. Two nodules contained air within the nodule. In four cases, pleural changes such as effusion and/or focal thickening were noted. No lymphadenopathy was found in all cases. Pathologically, the enhancing portion on CT showed findings of organizing pneumonia such as granulation tissue with fibroblast proliferation in alveolar space and interstitial thickening. The central low density areas on CT were due to ischemic necrosis, abscess and exudate, transudate and infiltration of foamy histiocyte. The possibility of focal organizing pneumonia should be considered when peripherally located solitary pulmonary nodule had enhancing component with no combined lymphadenopathy on CT scan

  18. Detection is unaffected by the deployment of focal attention

    Directory of Open Access Journals (Sweden)

    Jeff eMoher

    2013-05-01

    Full Text Available There has been much debate regarding how much information humans can extract from their environment without the use of limited attentional resources. In a recent study, Theeuwes, Van der Burg, and Belopolsky (2008 argued that even detection of simple feature targets is not possible without selection by focal attention. Supporting this claim, they found response time benefits in a simple feature (color detection task when a target letter’s identity was repeated on consecutive trials, suggesting that the letter was selected by focal attention and identified prior to detection. This intertrial repetition benefit remained even when observers were required to simultaneously identify a central digit. However, we found that intertrial repetition benefits disappeared when a simple color target was presented among a heterogeneously (rather than homogeneously colored set of distractors, thus reducing its bottom-up salience. Still, detection performance remained high. Thus, detection performance was unaffected by whether a letter was focally attended and identified prior to detection or not. Intertrial identity repetition benefits also disappeared when observers were required to perform a simultaneous, attention-demanding central task (Experiment 2, or when unfamiliar Chinese characters were used (Experiment 3. Together, these results suggest that while shifts of focal attention can be affected by target salience, by the availability of excess cognitive resources, and by target familiarity, detection performance itself is unaffected by these manipulations and is thus unaffected by the deployment of focal attention.

  19. EEG dynamical correlates of focal and diffuse causes of coma.

    Science.gov (United States)

    Kafashan, MohammadMehdi; Ryu, Shoko; Hargis, Mitchell J; Laurido-Soto, Osvaldo; Roberts, Debra E; Thontakudi, Akshay; Eisenman, Lawrence; Kummer, Terrance T; Ching, ShiNung

    2017-11-15

    Rapidly determining the causes of a depressed level of consciousness (DLOC) including coma is a common clinical challenge. Quantitative analysis of the electroencephalogram (EEG) has the potential to improve DLOC assessment by providing readily deployable, temporally detailed characterization of brain activity in such patients. While used commonly for seizure detection, EEG-based assessment of DLOC etiology is less well-established. As a first step towards etiological diagnosis, we sought to distinguish focal and diffuse causes of DLOC through assessment of temporal dynamics within EEG signals. We retrospectively analyzed EEG recordings from 40 patients with DLOC with consensus focal or diffuse culprit pathology. For each recording, we performed a suite of time-series analyses, then used a statistical framework to identify which analyses (features) could be used to distinguish between focal and diffuse cases. Using cross-validation approaches, we identified several spectral and non-spectral EEG features that were significantly different between DLOC patients with focal vs. diffuse etiologies, enabling EEG-based classification with an accuracy of 76%. Our findings suggest that DLOC due to focal vs. diffuse injuries differ along several electrophysiological parameters. These results may form the basis of future classification strategies for DLOC and coma that are more etiologically-specific and therefore therapeutically-relevant.

  20. A targeted resequencing gene panel for focal epilepsy.

    Science.gov (United States)

    Hildebrand, Michael S; Myers, Candace T; Carvill, Gemma L; Regan, Brigid M; Damiano, John A; Mullen, Saul A; Newton, Mark R; Nair, Umesh; Gazina, Elena V; Milligan, Carol J; Reid, Christopher A; Petrou, Steven; Scheffer, Ingrid E; Berkovic, Samuel F; Mefford, Heather C

    2016-04-26

    We report development of a targeted resequencing gene panel for focal epilepsy, the most prevalent phenotypic group of the epilepsies. The targeted resequencing gene panel was designed using molecular inversion probe (MIP) capture technology and sequenced using massively parallel Illumina sequencing. We demonstrated proof of principle that mutations can be detected in 4 previously genotyped focal epilepsy cases. We searched for both germline and somatic mutations in 251 patients with unsolved sporadic or familial focal epilepsy and identified 11 novel or very rare missense variants in 5 different genes: CHRNA4, GRIN2B, KCNT1, PCDH19, and SCN1A. Of these, 2 were predicted to be pathogenic or likely pathogenic, explaining ∼0.8% of the cohort, and 8 were of uncertain significance based on available data. We have developed and validated a targeted resequencing panel for focal epilepsies, the most important clinical class of epilepsies, accounting for about 60% of all cases. Our application of MIP technology is an innovative approach that will be advantageous in the clinical setting because it is highly sensitive, efficient, and cost-effective for screening large patient cohorts. Our findings indicate that mutations in known genes likely explain only a small proportion of focal epilepsy cases. This is not surprising given the established clinical and genetic heterogeneity of these disorders and underscores the importance of further gene discovery studies in this complex syndrome. © 2016 American Academy of Neurology.

  1. Terapia Interpessoal: um modelo breve e focal Interpersonal Therapy: a brief and focal model

    Directory of Open Access Journals (Sweden)

    Marcelo Feijó de Mello

    2004-06-01

    Full Text Available A psicoterapia é uma forma particular de tratamento em psiquiatria. Seu uso é amplamente difundido e conta com várias linhas de abordagem. OBJETIVO: Neste trabalho, o autor faz considerações a respeito da terapia interpessoal (TIP, uma forma breve e focal de psicoterapia. Inicialmente usada para o tratamento da depressão, teve seu espectro de ação ampliado para outros transtornos. A TIP pode ser dividida em 3 fases: inicial, quando é feito um diagnóstico do transtorno nomeando os sintomas ao paciente e diagnosticando o foco interpessoal a ser trabalhado; fase intermediária, onde se trabalha o foco; e fase final, quando o paciente é encorajado a reconhecer e consolidar seus ganhos para usá-los no futuro. MÉTODOS: O autor faz uma revisão das evidências científicas da eficácia da TIP no tratamento da depressão. CONCLUSÕES: Os resultados mostram que a TIP é uma forma terapêutica eficaz e bem tolerada de tratamento para a depressão.Psychotherapy is a particular form of treatment in Psychiatry. Its use is widespread and has many different approaches. OBJECTIVE: In this article, the author makes some considerations about Interpersonal Therapy (IPT, a brief and focal psychotherapy. Initially created to treat depression, other researchers had successfully increase its spectrum. It could be divided in three phases. Initial, when the therapist makes the diagnosis of the disorder and also the interpersonal problematic is pointed out; the patient received a sick role. Intermediary when the focus is treated, and the final phase when the therapist encourages the patient to recognize and consolidate gains and prepare the patient to use it in the future. METHODS: It is stressed that IPT is a testable form of psychotherapy and the scientific evidences of its efficacy are showed. CONCLUSIONS: The results assure that IPT is an efficient form of psychotherapy for depression with a great acceptability from the patients.

  2. Role of scintigraphy in focally abnormal sonograms of fatty livers

    International Nuclear Information System (INIS)

    Lisbona, R.; Mishkin, S.; Derbekyan, V.; Novales-Diaz, J.A.; Roy, A.; Sanders, L.

    1988-01-01

    Fatty infiltration of the liver may cause a range of focal abnormalities on hepatic sonography which may simulate hepatic nodular lesions. Discrete deposits of fat or islands of normal tissue which are uninvolved by fatty infiltration may stand out as potential space-occupying lesions on the sonograms. Twelve patients with such focally abnormal ultrasound images were referred for liver scintigraphy with 133 Xe and /sup 99m/Tc colloidal SPECT studies to clarify the issue. These examinations helped identify, in nine of 12 patients, the innocent nature of the sonographic abnormalities which were simply related to the fat deposition process. Further, [/sup 99m/Tc]RBC scans defined the additional pathologic process in three patients in whom actual space-occupying lesions were indeed present in the liver. Scintigraphy has an important role to play in the understanding of focal hepatic ultrasound abnormalities particularly in unsuspected hepatic steatosis

  3. Role of scintigraphy in focally abnormal sonograms of fatty livers

    Energy Technology Data Exchange (ETDEWEB)

    Lisbona, R.; Mishkin, S.; Derbekyan, V.; Novales-Diaz, J.A.; Roy, A.; Sanders, L.

    1988-06-01

    Fatty infiltration of the liver may cause a range of focal abnormalities on hepatic sonography which may simulate hepatic nodular lesions. Discrete deposits of fat or islands of normal tissue which are uninvolved by fatty infiltration may stand out as potential space-occupying lesions on the sonograms. Twelve patients with such focally abnormal ultrasound images were referred for liver scintigraphy with /sup 133/Xe and /sup 99m/Tc colloidal SPECT studies to clarify the issue. These examinations helped identify, in nine of 12 patients, the innocent nature of the sonographic abnormalities which were simply related to the fat deposition process. Further, (/sup 99m/Tc)RBC scans defined the additional pathologic process in three patients in whom actual space-occupying lesions were indeed present in the liver. Scintigraphy has an important role to play in the understanding of focal hepatic ultrasound abnormalities particularly in unsuspected hepatic steatosis.

  4. US and CT findings in splenic focal lesions in AIDS

    International Nuclear Information System (INIS)

    Schinina, V.; Rizzi, E.B.; Mazzuoli, G.; Bibbolilno, C.; David, V.

    2000-01-01

    To evaluate the role of US and CT in focal splenic lesions in AIDS patients in relation to etiology. Material and Methods: A total of 66 patients with AIDS and focal splenic lesions were examined with sonography. CT with administration of contrast medium was performed in 12 cases. Results: Of the focal splenic lesions, 67% were correlated with an infective pathology with prevalence of Mycobacteria tuberculosis (75%), 26% were neoplastic and 6% splenic infarcts. The lesions were hypoechoic in 60% of the cases, while 10% were hypoanechoic and 1% anechoic. At CT, all lesions appeared hypodense, even after i.v. administration of contrast medium. Conclusion: The combination of echographic reports and clinical and laboratory data allows for a diagnosis that can be confirmed, and making a decision for effective therapy of AIDS is possible. CT does not provide any additional information

  5. Simulation of the Focal Spot of the Accelerator Bremsstrahlung Radiation

    Science.gov (United States)

    Sorokin, V.; Bespalov, V.

    2016-06-01

    Testing of thick-walled objects by bremsstrahlung radiation (BR) is primarily performed via high-energy quanta. The testing parameters are specified by the focal spot size of the high-energy bremsstrahlung radiation. In determining the focal spot size, the high- energy BR portion cannot be experimentally separated from the low-energy BR to use high- energy quanta only. The patterns of BR focal spot formation have been investigated via statistical modeling of the radiation transfer in the target material. The distributions of BR quanta emitted by the target for different energies and emission angles under normal distribution of the accelerated electrons bombarding the target have been obtained, and the ratio of the distribution parameters has been determined.

  6. MRI of a family with focal abnormalities of gyration

    International Nuclear Information System (INIS)

    Muntaner, L.; Perez-Ferron, J.J.; Herrera, M.; Rosell, J.; Taboada, D.; Climent, S.

    1997-01-01

    Focal abnormalities of gyration (FAG) are developmental disorders that may occur in isolated patients or, as in the case being reported, as part of a familial disorder. Analysis of individuals in a family spanning three generations was carried out using MRI. Abnormalities, present in all members of generations II and III, included focal cortical dysplasia (three patients), focal cortical infolding (two patients) and schizencephaly (one patient); associated minor anomalies, such as white matter abnormalities, were seen in the remaining three members of generations II and III. MRI recognition of FAG in the family being reported proved useful in defining their phenotypical expression and providing proper counselling for individual family members. (orig.). With 6 figs

  7. Protein kinase C involvement in focal adhesion formation

    DEFF Research Database (Denmark)

    Woods, A; Couchman, J R

    1992-01-01

    Matrix molecules such as fibronectin can promote cell attachment, spreading and focal adhesion formation. Although some interactions of fibronectin with cell surface receptors have now been identified, the consequent activation of intracellular messenger systems by cell/matrix interactions have...... still to be elucidated. We show here that the kinase inhibitors H7 and HA1004 reduce focal adhesion and stress fiber formation in response to fibronectin in a dose-dependent manner, and that activators of protein kinase C can promote their formation under conditions where they do not normally form....... Fibroblasts spread within 1h on substrata composed of fibronectin and formed focal adhesions by 3h, as monitored by interference reflection microscopy (IRM) and by labeling for talin, vinculin and integrin beta 1 subunits. In addition, stress fibers were visible. When cells were allowed to spread for 1h...

  8. Focal depth measurement of scanning helium ion microscope

    International Nuclear Information System (INIS)

    Guo, Hongxuan; Itoh, Hiroshi; Wang, Chunmei; Zhang, Han; Fujita, Daisuke

    2014-01-01

    When facing the challenges of critical dimension measurement of complicated nanostructures, such as of the three dimension integrated circuit, characterization of the focal depth of microscopes is important. In this Letter, we developed a method for characterizing the focal depth of a scanning helium ion microscope (HIM) by using an atomic force microscope tip characterizer (ATC). The ATC was tilted in a sample chamber at an angle to the scanning plan. Secondary electron images (SEIs) were obtained at different positions of the ATC. The edge resolution of the SEIs shows the nominal diameters of the helium ion beam at different focal levels. With this method, the nominal shapes of the helium ion beams were obtained with different apertures. Our results show that a small aperture is necessary to get a high spatial resolution and high depth of field images with HIM. This work provides a method for characterizing and improving the performance of HIM.

  9. Earthquake focal mechanism forecasting in Italy for PSHA purposes

    Science.gov (United States)

    Roselli, Pamela; Marzocchi, Warner; Mariucci, Maria Teresa; Montone, Paola

    2018-01-01

    In this paper, we put forward a procedure that aims to forecast focal mechanism of future earthquakes. One of the primary uses of such forecasts is in probabilistic seismic hazard analysis (PSHA); in fact, aiming at reducing the epistemic uncertainty, most of the newer ground motion prediction equations consider, besides the seismicity rates, the forecast of the focal mechanism of the next large earthquakes as input data. The data set used to this purpose is relative to focal mechanisms taken from the latest stress map release for Italy containing 392 well-constrained solutions of events, from 1908 to 2015, with Mw ≥ 4 and depths from 0 down to 40 km. The data set considers polarity focal mechanism solutions until to 1975 (23 events), whereas for 1976-2015, it takes into account only the Centroid Moment Tensor (CMT)-like earthquake focal solutions for data homogeneity. The forecasting model is rooted in the Total Weighted Moment Tensor concept that weighs information of past focal mechanisms evenly distributed in space, according to their distance from the spatial cells and magnitude. Specifically, for each cell of a regular 0.1° × 0.1° spatial grid, the model estimates the probability to observe a normal, reverse, or strike-slip fault plane solution for the next large earthquakes, the expected moment tensor and the related maximum horizontal stress orientation. These results will be available for the new PSHA model for Italy under development. Finally, to evaluate the reliability of the forecasts, we test them with an independent data set that consists of some of the strongest earthquakes with Mw ≥ 3.9 occurred during 2016 in different Italian tectonic provinces.

  10. Hiperplasia epitelial focal de la boca en Colombia (Enfermedad de Heck

    Directory of Open Access Journals (Sweden)

    Gerzaín Rodríguez Toro

    1989-12-01

    Full Text Available El estudio de biopsias orales remitidas al INS por médicos y odontólogos en Servicio Social Obligatorio en la Amazonía y la Orinoquía y de especímenes de consulta enviados desde el Chocó, Boyacá y el Quindío, demuestra la amplia difusión de la hiperplasia epitelial focal en Colombia. La entidad tiene predominio notorio en las comunidades indígenas. Las lesiones son pápulas numerosas en las mucosas del labio inferior, los carrillos y los bordes de la lengua, que afectan a menores de 16 años y a algunos adultos.Tienden a evolucionar durante años y son asintomáticas. La histopatología revela hiperplasia epitelial global, anastomosis de las crestas, células mitosoides, vacuolización alta y frecuente binucleación de queratinocitos en la mitad superior del epitelio. Con la técnica de PAP y con M.E. se demuestra antígeno de Papilomavirus en las células malpighianas altas y en las células córneas paraqueratósicas. La HEP debe ser bien reconocida por médicos y odontólogos, principalmente por aquellos que prestan su servicio a comunidades indígenas.

  11. Nodular focal fatty infiltration of the liver: CT appearance

    International Nuclear Information System (INIS)

    Baker, M.E.; Silverman, P.M.

    1985-01-01

    Focal fatty infiltration of the liver is a well recognized entity generally characterized by a nonspherical, low-density area without significant mass effect. CT usually distinguishes this from focal liver processes such as abscess or metastasis by its sharply marginated, geographic pattern and lack of mass effect on hepatic and portal veins. Recently, the authors formed a CT scan of the liver in one patient in whom fatty infiltration appeared nodular or rounded. The clinical presentation and radiographic and pathologic features form the basis of this report

  12. The radiological features of Goltz syndrome: Focal dermal hypoplasia

    International Nuclear Information System (INIS)

    Boothyrod, A.E.; Hall, C.M.

    1988-01-01

    Two female infants with Goltz syndrome (focal dermal hypoplasia) were recently investigated for severe feeding problems and failure to thrive. Both demonstrated severe skeletal malformations and marked gastrooesophageal reflux with laxity of the hiatus. One child (case 1) exhibited nasal regurgitation during feeding. Interestingly, both children had undergone surgery; Case 1 or a right parasagittal abdominal hernia associated with focal dermal hypoplasia of the abdominal wall and Case 2 for an exomphalos also associated with dermal hypoplasia. This observation suggests more widespread mesodermal abnormality. (orig./GDG)

  13. Focal myositis of the thigh: unusual MR pattern

    International Nuclear Information System (INIS)

    Llauger, Jaume; Palmer, Jaume; San Roman, Luis; Bague, Silvia; Matias-Guiu, Xavier; Doncel, Antonio

    2002-01-01

    Focal myositis is a commonly referenced, infrequently reported and poorly documented benign inflammatory pseudotumor which may be misdiagnosed clinically as a malignant tumor. We report the clinicopathologic features and magnetic resonance imaging findings in a case of focal myositis in the thigh of a 55-year-old woman. A different radiologic presentation of this disorder is described. The gross appearance of the lesion, previously undescribed, appears to be rather specific for such a pseudoneoplastic disorder, and correlates very well with the magnetic resonance imaging features. (orig.)

  14. Focal myositis of the thigh: unusual MR pattern

    Energy Technology Data Exchange (ETDEWEB)

    Llauger, Jaume; Palmer, Jaume; San Roman, Luis [Department of Radiology, Hospital de la Santa Creu i Sant Pau, Barcelona (Spain); Bague, Silvia; Matias-Guiu, Xavier [Department of Pathology, Hospital de la Santa Creu i Sant Pau, Barcelona (Spain); Doncel, Antonio [Department of Orthopedic Surgery, Hospital de la Santa Creu i Sant Pau, Barcelona (Spain)

    2002-05-01

    Focal myositis is a commonly referenced, infrequently reported and poorly documented benign inflammatory pseudotumor which may be misdiagnosed clinically as a malignant tumor. We report the clinicopathologic features and magnetic resonance imaging findings in a case of focal myositis in the thigh of a 55-year-old woman. A different radiologic presentation of this disorder is described. The gross appearance of the lesion, previously undescribed, appears to be rather specific for such a pseudoneoplastic disorder, and correlates very well with the magnetic resonance imaging features. (orig.)

  15. Magnetic-resonance-guided biopsy of focal liver lesions

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Ethan A. [University of Michigan Health System, Section of Pediatric Radiology, C.S. Mott Children' s Hospital, Department of Radiology, Ann Arbor, MI (United States); Grove, Jason J. [University of Michigan Health System, Division of Interventional Radiology, C.S. Mott Children' s Hospital, Department of Radiology, Ann Arbor, MI (United States); Der Spek, Abraham F.L.V. [University of Michigan Health System, Department of Anesthesiology, C.S. Mott Children' s Hospital, Ann Arbor, MI (United States); Jarboe, Marcus D. [University of Michigan Health System, Division of Interventional Radiology, C.S. Mott Children' s Hospital, Department of Radiology, Ann Arbor, MI (United States); University of Michigan Health System, Section of Pediatric Surgery, C.S. Mott Children' s Hospital, Department of Surgery, Ann Arbor, MI (United States)

    2017-05-15

    Image-guided biopsy techniques are widely used in clinical practice. Commonly used methods employ either ultrasound (US) or computed tomography (CT) for image guidance. In certain patients, US or CT guidance may be suboptimal, or even impossible, because of artifacts, suboptimal lesion visualization, or both. We recently began performing magnetic resonance (MR)-guided biopsy of focal liver lesions in select pediatric patients with lesions that are not well visualized by US or CT. This report describes our experience performing MR-guided biopsy of focal liver lesions, with case examples to illustrate innovative techniques and novel aspects of these procedures. (orig.)

  16. Magnetic electroanatomical mapping for ablation of focal atrial tachycardias.

    Science.gov (United States)

    Marchlinski, F; Callans, D; Gottlieb, C; Rodriguez, E; Coyne, R; Kleinman, D

    1998-08-01

    Uniform success for ablation of focal atrial tachycardias has been difficult to achieve using standard catheter mapping and ablation techniques. In addition, our understanding of the complex relationship between atrial anatomy, electrophysiology, and surface ECG P wave morphology remains primitive. The magnetic electroanatomical mapping and display system (CARTO) offers an on-line display of electrical activation and/or signal amplitude related to the anatomical location of the recorded sites in the mapped chamber. A window of electrical interest is established based on signals timed from an electrical reference that usually represents a fixed electrogram recording from the coronary sinus or the atrial appendage. This window of electrical interest is established to include atrial activation prior to the onset of the P wave activity associated with the site of origin of a focal atrial tachycardia. Anatomical and electrical landmarks are defined with limited fluoroscopic imaging support and more detailed global chamber and more focal atrial mapping can be performed with minimal fluoroscopic guidance. A three-dimensional color map representing atrial activation or voltage amplitude at the magnetically defined anatomical sites is displayed with on-line data acquisition. This display can be manipulated to facilitate viewing from any angle. Altering the zoom control, triangle fill threshold, clipping plane, or color range can all enhance the display of a more focal area of interest. We documented the feasibility of using this single mapping catheter technique for localizing and ablating focal atrial tachycardias. In a consecutive series of 8 patients with 9 focal atrial tachycardias, the use of the single catheter CARTO mapping system was associated with ablation success in all but one patient who had a left atrial tachycardia localized to the medial aspect of the orifice of the left atrial appendage. Only low power energy delivery was used in this patient because of the

  17. Regional cerebral blood flow in focal cortical epilepsy

    DEFF Research Database (Denmark)

    Hougaard, Kristina Dupont; Oikawa, T; Sveinsdottir, E

    1976-01-01

    Regional cerebral blood flow (rCBF) was studied in ten patients with focal cortical epilepsy. The blood flow was measured by the intra-arterial injection of xenon 133 (133Xe), and the isotope clearance was recorded by a multidetector scintillation camera with 254 detectors. Three patients were....... This finding accords with earlier studies. All nine patients studied in the interictal phase showed, either spontaneously or during activation by intermittent light, focal flow increases in areas presumed to comprise the epileptic focus. These interictal hyperemic foci probably reflect subictal neuronal...

  18. Incidental Detection of Temporary Focal FDG Retention in the Spleen

    Energy Technology Data Exchange (ETDEWEB)

    Park, Youn Joon; Lee, Jai Hyuen; Jee, Keum Nahn; Namgung, Hwan [Dankook Univ. College of Medicine, Seoul (Korea, Republic of)

    2011-06-15

    F 18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) is a valuable tool in discriminating malignancy from benign lesion. But because various false positive results reduce the diagnostic specificity, nuclear medicine physicians should be familiar with possible false positive cases. Although many cases of high FDG uptake mimicking malignancy have been reported, temporary intense focal FDG uptake of normal spleen has not been reported previously. We report herein a phenomenon of temporary intense focal FDG uptake of normal spleen without evidence of metastasis in a 46 year old woman with a history of anal cancer.

  19. Expansion characteristics of coronary stents in focal stenoses

    Directory of Open Access Journals (Sweden)

    Schmidt Wolfram

    2017-09-01

    Full Text Available The presented experimental in vitro approach was designed to assess the expansion behavior of stent systems in a resistant focal stenosis model with respect to a potential dog-boning effect. Five different stent systems (nominal diameter 3.0 mm were investigated. The focal stenosis was simulated by a stainless steel tube (ID ≤ 1.20 mm. Stent expansion was performed using a proprietary test device consisting of a test chamber with 37 °C water, 2-axis laser scanner and a pressure controller.

  20. Adaptación en Pacientes con Diabetes Mellitus Type 2, Según Modelo de Roy

    OpenAIRE

    Lazcano Ortíz, Margarita; Salazar Gonzalez, Bertha C

    2009-01-01

    Objetivo. Determinar la influencia entre estímulos focales y contextuales, y la adaptación fisiológica y psicosocial en personas con diabetes Mellitus Tipo 2 (DMT2). Material y método. El diseño fue descriptivo, transversal, predictivo. El muestreo fue probabilístico, sistemático. La muestra con 200 participantes de ambos géneros de 30 a 65 años, se determinó para un 95% de confianza, con una potencia de prueba de 90%. Resultados. Los resultados mostraron que el tiempo desde diagnóst...

  1. Adaptación en pacientes con diabetes Mellitus Tipo 2, según Modelo de Roy

    OpenAIRE

    Margarita Lazcano-Ortiz; Bertha Cecilia Salazar-González

    2009-01-01

    Objetivo. Determinar la influencia entre estímulos focales y contextuales, y la adaptación fisiológica y psicosocial en personas con diabetes Mellitus Tipo 2 (DMT2). Material y método. El diseño fue descriptivo, transversal, predictivo. El muestreo fue probabilístico, sistemático. La muestra con 200 participantes de ambos géneros de 30 a 65 años, se determinó para un 95% de confianza, con una potencia de prueba de 90%. Resultados. Los resultados mostraron que el tiempo desde diagnóstico expli...

  2. preescolares desnutridos con madres con obesidad y sin obesidad

    Directory of Open Access Journals (Sweden)

    Viridiana Vanessa Conzuelo-González

    2009-01-01

    Full Text Available El primer objetivo fue conocer cuántos menores de cinco años con diferentes grados de desnutrición tienen una madre con sobrepeso/obesidad/ en una comunidad indígena que vive en extrema pobreza y bajo condiciones de migración masculina internacional. El segundo fue comparar tres variables socionutricionales (ingreso familiar, educación de la madre y adecuación nutrimental de la dieta diaria entre estos hogares y los hogares con desnutrición infantil y madres sin obesidad. Se realizó un estudio transversal (2006-2007, en la comunidad mazahua de San Francisco Tepeolulco, Municipio de Temascalcingo; que incluyó a 85 hogares integrados por preescolares con desnutrición inscritos al programa Oportunidades. Se determinó el estado nutrición de los preescolares con indicadores antropométricos y se obtuvo el IMC de las madres de estos infantes. Se aplicó una encuesta socionutricional, incluida el recordatorio de 24 horas, y complementado con la observación participante (cualitativa. Se encontró que 83% de las madres mazahuas presentaron sobrepeso u obesidad. El estado de nutrición de los preescolares con madres con obesidad presentó un porcentaje mayor de desnutrición (76%. En la variable género, se encontró que 54% de los niños con madres con obesidad tenía baja talla. Al relacionar el nivel educativo de la madre, esta variable resultó ser estadísticamente significativa (p=0.015, donde el analfabetismo está más relacionado con la desnutrición infantil que tienen madres de bajo y/o peso normal. La elevada prevalencia de hogares conformados con preescolares con desnutrición y madres con obesidad, es un síntoma más de la pobreza en zonas indígenas en México, con bajo índice de desarrollo humano.

  3. Focal symmetrical encephalomalacia in sheep Encefalomalacia focal simétrica em ovino

    Directory of Open Access Journals (Sweden)

    Luciano A. Pimentel

    2010-05-01

    Full Text Available Focal symmetrical encephalomalacia (FSE is the most prominent lesion seen in the chronic form of enterotoxemia by Clostridium perfringens type D. This paper reports FSE in sheep in Brazil. Six deaths occurred within a seven days period in a flock of 70, four to 30-month-old Santa Inês sheep in the state of Paraíba in the Brazilian semiarid. The flock was grazing a paddock of irrigated sprouting Cynodon dactylon (Tifton grass, and supplemented, ad libitum, with a concentrate of soybean, corn and wheat. Nervous signs included blindness and recumbence. A 19 month-old sheep was examined clinically and necropsied after a clinical course of three days. Gross lesions were herniation of the cerebellar vermis and multifocal, bilateral, symmetric brownish areas in the internal capsule, thalamus and cerebellar peduncles. Histologic lesions were multifocal, bilateral malacia with some neutrophils, swelling of blood vessels endothelium, perivascular edema, and hemorrhages. The flock was vaccinated, before the outbreak, with only one dose of Clostridium perfringens type D vaccine. Two factors are suggested to be important for the occurrence of the disease: insufficient immunity due to the incorrect vaccination; and high nutritional levels by the supplementation with highly fermentable carbohydrates.Encefalomalacia focal simétrica (EFS é a lesão mais proeminente vista nas formas subaguda ou crônica da enterotoxemia por Clostridium perfringens tipo D. Este trabalho relata EFS em ovinos no semiárido do estado da Paraíba. Seis ovinos morreram, em um período de sete dias, dentro de um rebanho de 70 animais, da raça Santa Inês, entre 4-30 meses de idade, que pastavam em piquete de Cynodon dactylon (capim Tifton, que estava rebrotando. Os ovinos eram suplementados com um concentrado de soja, trigo e milho. Os sinais nervosos incluíam cegueira e decúbito lateral. Um ovino de 19 meses de idade foi examinado clinicamente e necropsiado, depois de um curso

  4. Idiopathic focal segmental glomerulosclerosis: a favourable prognosis in untreated patients?

    NARCIS (Netherlands)

    Deegens, J.K.J.; Assmann, K.J.M.; Steenbergen, E.; Hilbrands, L.B.; Gerlag, P.G.G.; Jansen, J.L.; Wetzels, J.F.M.

    2005-01-01

    BACKGROUND: Patients with focal segmental glomerulosclerosis (FSGS) are considered to have a poor prognosis and spontaneous remissions are seldom reported. However, FSGS is not a single disease entity. Our aim was to describe the clinical course in initially untreated patients with recently

  5. Laser Beam Caustic Measurement with Focal Spot Analyser

    DEFF Research Database (Denmark)

    Olsen, Flemming Ove; Gong, Hui; Bagger, Claus

    2005-01-01

    In industrial applications of high power CO2-lasers the caustic characteristics of the laser beam have great effects on the performance of the lasers. A welldefined high intense focused spot is essential for reliable production results. This paper presents a focal spot analyser that is developed...

  6. Mass Equivalent Pantographs for Synthesis of Balanced Focal Mechanisms

    NARCIS (Netherlands)

    van der Wijk, V.; Lenarcic, Jadran; Merlet, Jean-Pierre

    2016-01-01

    Force balance is an important property in the design of high-speed high precision machinery to reduce base vibrations and also for the design of inherently safe large movable structures. This paper presents the synthesis of inherently balanced overconstrained focal mechanisms with mass equivalent

  7. A 1.3 giga pixels focal plane for GAIA

    Science.gov (United States)

    Laborie, Anouk; Pouny, Pierre; Vetel, Cyril; Collados, Emmanuel; Rougier, Gilles; Davancens, Robert; Zayer, Igor; Perryman, Michael; Pace, Oscar

    2004-06-01

    The astrometric mission GAIA is a cornerstone mission of the European Space Agency, due for launch in the 2010 time frame. Requiring extremely demanding performance GAIA calls for the development of an unprecedented large focal plane featuring innovative technologies. For securing the very challenging GAIA development, a significant number of technology activities have been initiated by ESA through a competitive selection process. In this context, an industrial consortium led by EADS-Astrium (France) with e2v technologies (UK) as major subcontractor was selected for the GAIA CCD and Focal Plane Technology Demonstrators programme, which is by far the most significant and the most critical GAIA pre-development for all aspects: science performance, development schedule and cost. This programme has started since August 2002 and will end early 2005 prior to commencement of the GAIA Phase B. While the GAIA payload will host three instruments and related focal planes, the major mission objectives are assigned to the Astrometric (ASTRO) Focal Plane, which is the subject of this presentation.

  8. A case of pathological rib fractures: focal osteolysis or osteoporosis?

    Science.gov (United States)

    Vrbanić, T S L; Novak, S; Sestan, B; Tudor, A; Gulan, G

    2008-03-01

    This paper reports on a unique, previously unreported, successful outcome in the case of a patient with focal osteolytic lesions of the ribs as a first sign of osteoporosis. The lesions were detected by chance after acute cough-induced rib fractures were seen on plain chest radiographs. The diagnosis had to be approached as a diagnosis of exclusion since known causes of the osteolytic process had to be eliminated. The authors describe multiple focal osteolytic lesions with rib fractures appearing in a pattern that could be confused with metastases. Laboratory results were normal. Final diagnosis was based on plain radiography, bone scan and bone densitometry. Pharmacomedical treatments for osteoporosis were applied. The patient was observed between the year 2000 and 2005. Five years later radiological and bone scintigraphy revealed resolution of the lesion. We conclude that osteoporosis should be included in the differential diagnosis of asymptomatic focal osteolysis of the ribs with rib fractures as a complication of acute cough. The case suggests that focal osteolytic lesions of the ribs may regress over time and become scintigraphically inactive.

  9. Shared Focal Plane Investigation for Serial Frame Cameras.

    Science.gov (United States)

    1980-03-01

    capability will be restored. 41. -.. TrABLE 1-1 SYSTEM LEADING P) ARTICULARS Lens Focal Length (inches) Range (ft) Contrast 12 18 24 Coverage 22.1...can be expected that signature bands will be apparent in the imagery. Such bands are at best distracting and at worst hindrances to image interpretation

  10. Tratamento focal e perifocal contra Aëdes aegypti

    Directory of Open Access Journals (Sweden)

    Milton Moura Lima

    1987-06-01

    Full Text Available Em quatro bairros da cidade do Rio de Janeiro, foram feitos ensaios de tratamento focal com abate granulado a 1 ppm e perifocal com pó molhável de Sumition a 2,5%. Esses tratamentos foram feitos tanto isoladamente quanto em conjunto e, também, associados à aplicação de inseticida a ultrabaixo volume. Os índices prediais, levantados um mês depois de terminado o trabalho, mostraram que o tratamento focal dispensa qualquer medida auxiliar. O tratamento perifocal mostrou-se inócuo e incapaz de impedir o aparecimento de larvas de Aëdes aegypti e de outros insetos, em pneus pintados, na face externa, com Sumition e com Malation.In four districts of the city of Rio dc Janeiro focal treatment essays with granulated Abate at 1 ppm and perifocal treatment essays with wettable powder of Sumithion at 2,5% were performed. These were made either alone or in combination as well as associated to insecticides applied at ultra low volume. The premise indices obtained one month after the treatments indicates that the focal treatment alone is effective, no other addicional methods being necessary. The perifocal treatment is not effective and did not prevent the development of Aedes aegypti larvae and other insects in tires which had their external surface painted with Sumithion and Malathion.

  11. Axial and focal-plane diffraction catastrophe integrals

    International Nuclear Information System (INIS)

    Berry, M V; Howls, C J

    2010-01-01

    Exact expressions in terms of Bessel functions are found for some of the diffraction catastrophe integrals that decorate caustics in optics and mechanics. These are the axial and focal-plane sections of the elliptic and hyperbolic umbilic diffraction catastrophes, and symmetric elliptic and hyperbolic unfoldings of the X 9 diffraction catastrophes. These representations reveal unexpected relations between the integrals.

  12. Neurophysiological evidence for cerebellar dysfunction in primary focal dystonia.

    NARCIS (Netherlands)

    Teo, J.T.; Warrenburg, B.P.C. van de; Schneider, S.A.; Rothwell, J.C.; Bhatia, K.P.

    2009-01-01

    Recent studies have suggested that there may be functional and structural changes in the cerebellum of patients with adult onset primary focal dystonia. The aim of this study was to establish whether there is any neurophysiological indicator of abnormal cerebellar function, using the classic

  13. The Localizing Value Of Focal Delta Slowing In Temporal Lobe ...

    African Journals Online (AJOL)

    Slow wave EEG had a higher marginal probability than neuropsychological assessment of predicting the focus, and was equally effective as other investigative methods. Conclusion These results suggest that focal temporal delta slowing is useful in the localization of epileptogenic foci. There was no discordance with the ...

  14. Management of HIV-associated focal brain lesions in developing ...

    African Journals Online (AJOL)

    Background. HIV-associated focal brain lesions (FBLs) are caused by opportunistic infections, neoplasms, or cerebrovascular diseases. In developed countries toxoplasma encephalitis (TE) is the most frequent cause followed by primary CNS lymphoma (PCNSL). Guidelines based on these causes have been proposed ...

  15. Quantum-Well Infrared Photodetector (QWIP) Focal Plane Assembly

    Science.gov (United States)

    Jhabvala, Murzy; Jhabvala, Christine A.; Ewin, Audrey J.; Hess, Larry A.; Hartmann, Thomas M.; La, Anh T.

    2012-01-01

    A paper describes the Thermal Infrared Sensor (TIRS), a QWIP-based instrument intended to supplement the Operational Land Imager (OLI) for the Landsat Data Continuity Mission (LDCM). The TIRS instrument is a far-infrared imager operating in the pushbroom mode with two IR channels: 10.8 and 12 microns. The focal plane will contain three 640x512 QWIP arrays mounted on a silicon substrate. The silicon substrate is a custom-fabricated carrier board with a single layer of aluminum interconnects. The general fabrication process starts with a 4-in. (approx.10-cm) diameter silicon wafer. The wafer is oxidized, a single substrate contact is etched, and aluminum is deposited, patterned, and alloyed. This technology development is aimed at incorporating three large-format infrared detecting arrays based on GaAs QWIP technology onto a common focal plane with precision alignment of all three arrays. This focal plane must survive the rigors of flight qualification and operate at a temperature of 43 K (-230 C) for five years while orbiting the Earth. The challenges presented include ensuring thermal compatibility among all the components, designing and building a compact, somewhat modular system and ensuring alignment to very tight levels. The multi-array focal plane integrated onto a single silicon substrate is a new application of both QWIP array development and silicon wafer scale integration. The Invar-based assembly has been tested to ensure thermal reliability.

  16. [Primary focal dystonia: descriptive study of 205 patients].

    Science.gov (United States)

    Bartolomé, F M; Fanjul, S; Cantarero, S; Hernández, J; García Ruiz, P J

    2003-03-01

    To describe the clinical and epidemiologic aspects of different types of focal dystonia. A total of 205 patients with primary focal dystonia were studied retrospectively and the following variables were analyzed: gender, age of onset, age at examination, evolution time, history of trauma, association with other movement disorders, fluctuations of dystonic symptoms as well as a family history of dystonia, Parkinson's disease, tremor, and lefthandedness or stuttering. We compared these variables among the different clinical categories of focal dystonia. Those patients with cranial and laryngeal dystonia were significantly older at the onset of symptoms compared with patients with writer's cramp. Males were more prevalent than females in all categories of focal dystonia except for cranial dystonia. Prior history of trauma and association with tremor were more frequent in patients with cervical dystonia than in those with others dystonic categories. Most patients with cranial, cervical and laryngeal dystonia had fluctuations in the intensity of dystonic symptoms, unlike the patients with writer's cramp. There is a caudo-cranial gradient in age of onset and the age of onset increases as the cranial presentation becomes greater. Females are more prevalent in cranial dystonia and there is a preponderance of males in the dystonias with a lower location. The dystonias with cranial distribution frequently present fluctuations of symptoms during the day. Association with other movement disorders, such as tremor, and prior history of trauma, is common in patients with cervical dystonia.

  17. Focal fibrocartilaginous dysplasia and tibia vara: a case report

    International Nuclear Information System (INIS)

    Cockshott, W.P.; Martin, R.; Friedman, L.; Yuen, M.

    1994-01-01

    A 2-year-old black boy with focal fibrocartilaginous dysplasia is described with illustrations of the typical radiographic appearances supplemented by computed tomographic and magnetic resonance images. Since this rare condition is self-correcting, diagnosis is important so that surgical intervention and biopsy can be avoided and conservative management instituted. (orig.)

  18. Focal fibrocartilaginous dysplasia and tibia vara: a case report.

    Science.gov (United States)

    Cockshott, W P; Martin, R; Friedman, L; Yuen, M

    1994-07-01

    A 2-year-old black boy with focal fibrocartilaginous dysplasia is described with illustrations of the typical radiographic appearances supplemented by computed tomographic and magnetic resonance images. Since this rare condition is self-correcting, diagnosis is important so that surgical intervention and biopsy can be avoided and conservative management instituted.

  19. Focal fibrocartilaginous dysplasia and tibia vara: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Cockshott, W.P. (Dept. of Radiology, McMaster Univ. Medical Centre, Hamilton, ON (Canada)); Martin, R. (Dept. of Orthopedics, McMaster Univ. Medical Centre, Hamilton, ON (Canada)); Friedman, L. (Dept. of Radiology, McMaster Univ. Medical Centre, Hamilton, ON (Canada)); Yuen, M. (Dept. of Radiology, McMaster Univ. Medical Centre, Hamilton, ON (Canada))

    1994-07-01

    A 2-year-old black boy with focal fibrocartilaginous dysplasia is described with illustrations of the typical radiographic appearances supplemented by computed tomographic and magnetic resonance images. Since this rare condition is self-correcting, diagnosis is important so that surgical intervention and biopsy can be avoided and conservative management instituted. (orig.)

  20. Contrast enhanced ultrasound in CT-undetermined focal liver lesions

    DEFF Research Database (Denmark)

    Sandrose, Sebastian; Karstrup, S.; Gerke, Oke

    2016-01-01

    , surgical resection, PET/CT and clinical follow-up. Results: The 78 included patients had 163 undetermined focal liver lesions, mean size 1.1 cm, range 0.1–5.3 cm. There were 18 malignant and 145 benign liver lesions, as defined by the standard of reference. In differentiating between benign vs. malignant...

  1. Automatic test comes to focal plane array production

    Science.gov (United States)

    Skaggs, Frank L.; Barton, T. D.

    1992-08-01

    To meet the needs of military and commercial markets, the infrared focal plane array industry must develop new, effective and low cost methods of fabricating and testing imaging detectors. This paper describes Texas Instruments new concepts in automated testing and cold probe technology as they apply to volume production.

  2. Focal irreversible electroporation as primary treatment for localized prostate cancer

    NARCIS (Netherlands)

    van den Bos, Willemien; Scheltema, Matthijs J.; Siriwardana, Amila R.; Kalsbeek, Anton M. F.; Thompson, James E.; Ting, Francis; Böhm, Maret; Haynes, Anne-Maree; Shnier, Ron; Delprado, Warick; Stricker, Phillip D.

    2017-01-01

    To determine the safety, quality of life (QoL) and short-term oncological outcomes of primary focal IRE for the treatment of localized prostate cancer. To identify potential risk factors for oncological failure. Patients that met both the consensus guidelines on patient criteria and selection

  3. Position sensitive proportional counters as focal plane detectors

    International Nuclear Information System (INIS)

    Ford, J.L.C. Jr.

    1979-01-01

    The rise time and charge division techniques for position decoding with RC-line proportional counters are reviewed. The advantages that these detectors offer as focal plane counters for nuclear spectroscopy performed with magnetic spectrographs are discussed. The theory of operation of proportional counters as position sensing devices is summarized, as well as practical aspects affecting their application. Factors limiting the position and energy resolutions obtainable with a focal plane proportional counter are evaluated and measured position and energy loss values are presented for comparison. Detector systems capable of the multiparameter measurements required for particle identification, background suppression and ray-tracing are described in order to illustrate the wide applicability of proportional counters within complex focal plane systems. Examples of the use of these counters other than with magnetic spectrographs are given in order to demonstrate their usefulness in not only nuclear physics but also in fields such as solid state physics, biology, and medicine. The influence of the new focal plane detector systems on future magnetic spectrograph designs is discussed. (Auth.)

  4. White matter integrity and cerebral network topology in focal epilepsy

    NARCIS (Netherlands)

    Otte, W.M.

    2012-01-01

    Worldwide more than fifty million people suffer from recurrent spontaneous seizures. Seizures are considered to be harmful to the brain and may have adverse long-term behavioral and cognitive consequences in particular in people with focal epilepsies that do not respond to pharmacotherapy.

  5. Mutations in KCNT1 cause a spectrum of focal epilepsies

    Science.gov (United States)

    Møller, Rikke S.; Heron, Sarah E.; Larsen, Line H. G.; Lim, Chiao Xin; Ricos, Michael G.; Bayly, Marta A.; van Kempen, Marjan J. A.; Klinkenberg, Sylvia; Andrews, Ian; Kelley, Kent; Ronen, Gabriel M.; Callen, David; McMahon, Jacinta M.; Yendle, Simone C.; Carvill, Gemma L.; Mefford, Heather C.; Nabbout, Rima; Poduri, Annapurna; Striano, Pasquale; Baglietto, Maria G.; Zara, Federico; Smith, Nicholas J.; Pridmore, Clair; Gardella, Elena; Nikanorova, Marina; Dahl, Hans Atli; Gellert, Pia; Scheffer, Ingrid E.; Gunning, Boudewijn; Kragh-Olsen, Bente; Dibbens, Leanne M.

    2018-01-01

    Summary Autosomal dominant mutations in the sodium-gated potassium channel subunit gene KCNT1 have been associated with two distinct seizure syndromes, nocturnal frontal lobe epilepsy (NFLE) and malignant migrating focal seizures of infancy (MMFSI). To further explore the phenotypic spectrum associated with KCNT1, we examined individuals affected with focal epilepsy or an epileptic encephalopathy for mutations in the gene. We identified KCNT1 mutations in 12 previously unreported patients with focal epilepsy, multifocal epilepsy, cardiac arrhythmia, and in a family with sudden unexpected death in epilepsy (SUDEP), in addition to patients with NFLE and MMFSI. In contrast to the 100% penetrance so far reported for KCNT1 mutations, we observed incomplete penetrance. It is notable that we report that the one KCNT1 mutation, p.Arg398Gln, can lead to either of the two distinct phenotypes, ADNFLE or MMFSI, even within the same family. This indicates that genotype–phenotype relationships for KCNT1 mutations are not straightforward. We demonstrate that KCNT1 mutations are highly pleiotropic and are associated with phenotypes other than ADNFLE and MMFSI. KCNT1 mutations are now associated with Ohtahara syndrome, MMFSI, and nocturnal focal epilepsy. They may also be associated with multifocal epilepsy and cardiac disturbances. PMID:26122718

  6. Differential diagnosis of focal pancreatitis and pancreatic cancer

    NARCIS (Netherlands)

    van Gulik, T. M.; Moojen, T. M.; van Geenen, R.; Rauws, E. A.; Obertop, H.; Gouma, D. J.

    1999-01-01

    The differentiation of focal, chronic pancreatitis (CP) and pancreatic cancer (PAC) poses a diagnostic dilemma. Both conditions may present with the same symptoms and signs. The complexity of differential diagnosis is enhanced because PAC is frequently associated with secondary inflammatory changes

  7. Mutations in KCNT1 cause a spectrum of focal epilepsies

    DEFF Research Database (Denmark)

    Møller, Rikke Steensbjerre; Heron, Sarah E.; Larsen, Line H. G.

    2015-01-01

    Autosomal dominant mutations in the sodium-gated potassium channel subunit gene KCNT1 have been associated with two distinct seizure syndromes, nocturnal frontal lobe epilepsy (NFLE) and malignant migrating focal seizures of infancy (MMFSI). To further explore the phenotypic spectrum associated w...

  8. Dosimetry Modeling for Focal Low-Dose-Rate Prostate Brachytherapy

    Energy Technology Data Exchange (ETDEWEB)

    Al-Qaisieh, Bashar [Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds (United Kingdom); Mason, Josh, E-mail: joshua.mason@nhs.net [Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds (United Kingdom); Bownes, Peter; Henry, Ann [Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds (United Kingdom); Dickinson, Louise [Division of Surgery and Interventional Science, University College London, London (United Kingdom); Department of Radiology, Northwick Park Hospital, London North West NHS Trust, London (United Kingdom); Ahmed, Hashim U. [Division of Surgery and Interventional Science, University College London, London (United Kingdom); University College London Hospital, London (United Kingdom); Emberton, Mark [University College London Hospital, London (United Kingdom); Langley, Stephen [St Luke' s Cancer Centre, Guildford (United Kingdom)

    2015-07-15

    Purpose: Focal brachytherapy targeted to an individual lesion(s) within the prostate may reduce side effects experienced with whole-gland brachytherapy. The outcomes of a consensus meeting on focal prostate brachytherapy were used to investigate optimal dosimetry of focal low-dose-rate (LDR) prostate brachytherapy targeted using multiparametric magnetic resonance imaging (mp-MRI) and transperineal template prostate mapping (TPM) biopsy, including the effects of random and systematic seed displacements and interseed attenuation (ISA). Methods and Materials: Nine patients were selected according to clinical characteristics and concordance of TPM and mp-MRI. Retrospectively, 3 treatment plans were analyzed for each case: whole-gland (WG), hemi-gland (hemi), and ultra-focal (UF) plans, with 145-Gy prescription dose and identical dose constraints for each plan. Plan robustness to seed displacement and ISA were assessed using Monte Carlo simulations. Results: WG plans used a mean 28 needles and 81 seeds, hemi plans used 17 needles and 56 seeds, and UF plans used 12 needles and 25 seeds. Mean D90 (minimum dose received by 90% of the target) and V100 (percentage of the target that receives 100% dose) values were 181.3 Gy and 99.8% for the prostate in WG plans, 195.7 Gy and 97.8% for the hemi-prostate in hemi plans, and 218.3 Gy and 99.8% for the focal target in UF plans. Mean urethra D10 was 205.9 Gy, 191.4 Gy, and 92.4 Gy in WG, hemi, and UF plans, respectively. Mean rectum D2 cm{sup 3} was 107.5 Gy, 77.0 Gy, and 42.7 Gy in WG, hemi, and UF plans, respectively. Focal plans were more sensitive to seed displacement errors: random shifts with a standard deviation of 4 mm reduced mean target D90 by 14.0%, 20.5%, and 32.0% for WG, hemi, and UF plans, respectively. ISA has a similar impact on dose-volume histogram parameters for all plan types. Conclusions: Treatment planning for focal LDR brachytherapy is feasible. Dose constraints are easily met with a notable

  9. METHOD FOR DETERMINATION OF FOCAL PLANE LOCATION OF FOCUSING COMPONENTS

    Directory of Open Access Journals (Sweden)

    A. I. Ivashko

    2017-01-01

    Full Text Available Mass-production of different laser systems often requires utilization of the focal spot size method for determination of output laser beam spatial characteristics. The main challenge of this method is high accuracy maintenance of a CCD camera beam profiler in the collecting lens focal plane. The aim of our work is development of new method for placing of photodetector array in the collecting lens focal plane with high accuracy.Proposed technique is based on focusing of several parallel laser beams. Determination of the focal plane position requires only longitudinal translation of the CCD-camera to find a point of laser beams intersection. Continuous-wave (CW diode-pumped laser emitting in the spectral region near 1μm was created to satisfy the requirements of the developed technique. Designed microchip laser generates two stigmatic Gaussian beams with automatically parallel beam axes due to independent pumping of different areas of the one microchip crystal having the same cavity mirrors.It was theoretically demonstrated that developed method provides possibility of the lenses focal plane determination with 1 % accuracy. The microchip laser generates two parallel Gaussian beams with divergence of about 10 mrad. Laser output power can be varied in the range of 0.1–1.5 W by changing the pumping laser diode electrical current. The distance between two beam axes can be changed in the range of 0.5–5.0 mm.We have proposed method for determination of positive lens focal plane location by using of CCDcamera and two laser beams with parallel axes without utilization of additional optical devices. We have developed CW longitudinally diode pumped microchip laser emitting in the 1-μm spectral region that can be used in the measuring instrument that doesn’t require precision mechanical components for determination of focal plane location with 1 % accuracy. The overall dimensions of laser head was 70 × 40 × 40 mm3 and maximum power consumption was

  10. autorregulado con estudiantes universitarios

    Directory of Open Access Journals (Sweden)

    Jairo Andrés Montes

    2005-01-01

    Full Text Available El propósito del presente estudio es describir la forma en la que se presentan los procesos de aprendizaje autorregulado con un grupo de estudiantes (22 estudiantes de tercer semestre de Psicología de la PUJ, Cali, en el evento de preparación para la presentación un examen. Asimismo se describen las correlaciones que ocurren entre las distintas fases de dicho proceso de autorregulación del aprendizaje. Para conseguir los objetivos propuestos se ha hecho uso de una observación de desempeño en tiempo real, es decir, de la observación durante una sesión de preparación de examen de los estudiantes, en la cual se emplearon protocolos verbales para dar cuenta de lo que «pasaba por su mente» mientras estudiaban. Una entrevista semi-estructurada y una prueba objetiva. Los resultados fueron analizados a la luz del modelo mixto de procesamiento de información y constructivismo abordado por Winne(1998. Como resultado se encontró una relación significativa entre los niveles de desempeño en el proceso de ARR y el resultado del examen. Igualmente se encontraron bajos niveles de regulación en una parte importante de la muestra y un desfase significativo entre conocimiento declarativo de ARR y desempeño en el mismo

  11. Context cue focality influences strategic prospective memory monitoring.

    Science.gov (United States)

    Hunter Ball, B; Bugg, Julie M

    2018-02-12

    Monitoring the environment for the occurrence of prospective memory (PM) targets is a resource-demanding process that produces cost (e.g., slower responding) to ongoing activities. However, research suggests that individuals are able to monitor strategically by using contextual cues to reduce monitoring in contexts in which PM targets are not expected to occur. In the current study, we investigated the processes supporting context identification (i.e., determining whether or not the context is appropriate for monitoring) by testing the context cue focality hypothesis. This hypothesis predicts that the ability to monitor strategically depends on whether the ongoing task orients attention to the contextual cues that are available to guide monitoring. In Experiment 1, participants performed an ongoing lexical decision task and were told that PM targets (TOR syllable) would only occur in word trials (focal context cue condition) or in items starting with consonants (nonfocal context cue condition). In Experiment 2, participants performed an ongoing first letter judgment (consonant/vowel) task and were told that PM targets would only occur in items starting with consonants (focal context cue condition) or in word trials (nonfocal context cue condition). Consistent with the context cue focality hypothesis, strategic monitoring was only observed during focal context cue conditions in which the type of ongoing task processing automatically oriented attention to the relevant features of the contextual cue. These findings suggest that strategic monitoring is dependent on limited-capacity processing resources and may be relatively limited when the attentional demands of context identification are sufficiently high.

  12. Variáveis psicológicas envolvidas na qualidade de vida de portadores de epilepsia Psychological variables involved in the quality of life of patients with epilepsy

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    Priscila Camile Barioni Salgado

    2003-04-01

    Full Text Available O diagnóstico de epilepsia acarreta um rompimento na maneira como o indivíduo se percebe, na sua vida social e econômica e nos seus planos de futuro. Este estudo buscou avaliar variáveis psicológicas (percepção de controle de crises e características da doença na determinação da qualidade de vida (QV de pacientes adultos com diagnóstico de epilepsia há mais de dois anos. Foram avaliados 60 participantes, aleatoriamente selecionados no ambulatório de epilepsia do HC/Unicamp, com idade entre 18 e 70 anos (M = 37,05; DP = 11,25, através do Questionário de Qualidade de Vida 65 (QQV-65. As variáveis da doença não foram significativas, com exceção da freqüência de crises, que apareceu associada à piora na QV, entre crises controladas e crises com freqüência acima de 10 por mês (p = 0,021. A percepção do controle de crises apareceu significativamente associada à QV (p = 0,005. A interpretação subjetiva de crises controla a resposta de ajustamento à doença e do senso de bem-estar geral e explicam porque a QV é melhor nos participantes livres de crises.The epilepsy diagnostic breaks the way people used to perceive themselves, and tends to destroy their social and economical life, as well as their plans for the future. This study searched for the evaluation of psychological variables (perception of seizure control and the illness characteristics determining the quality of life (QoL in patients with the diagnostic of epilepsy for over two years. The sample consisted of 60 individuals with chronic epilepsy, aging 18 to 70 (M = 37.05; SD = 11.25, chosen at random from the outpatient clinic of epilepsy - University Hospital of Campinas /UNICAMP and evaluated by means of the Questionnaire of Quality of Life 65 (QQV-65. The illness characteristics were not statistically significant, except the seizures frequency, when associated to the impairment in QoL among controlled seizures and seizures with frequency higher than 10 per

  13. Flotillins Regulate Focal Adhesions by Interacting with α-Actinin and by Influencing the Activation of Focal Adhesion Kinase

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    Antje Banning

    2018-04-01

    Full Text Available Cell–matrix adhesion and cell migration are physiologically important processes that also play a major role in cancer spreading. In cultured cells, matrix adhesion depends on integrin-containing contacts such as focal adhesions. Flotillin-1 and flotillin-2 are frequently overexpressed in cancers and are associated with poor survival. Our previous studies have revealed a role for flotillin-2 in cell–matrix adhesion and in the regulation of the actin cytoskeleton. We here show that flotillins are important for cell migration in a wound healing assay and influence the morphology and dynamics of focal adhesions. Furthermore, anchorage-independent growth in soft agar is enhanced by flotillins. In the absence of flotillins, especially flotillin-2, phosphorylation of focal adhesion kinase and extracellularly regulated kinase is diminished. Flotillins interact with α-actinin, a major regulator of focal adhesion dynamics. These findings are important for understanding the molecular mechanisms of how flotillin overexpression in cancers may affect cell migration and, especially, enhance metastasis formation.

  14. Puentes con vigas pretensadas

    Directory of Open Access Journals (Sweden)

    Editorial, Equipo

    1965-07-01

    Full Text Available This paper describes one of the three bridges which Hidrocivil, S. A., has built in Catalonia (northern Spain, over the river Ripoll. The other two bridges are very similar to this one, both in construction and design, and show only minor adjustments to the local topography. The contracting firm proposed several alterations in the prefabrication and constructional procedure, in relation to the initial project, and these changes were accepted. The main feature of these projects is the use of prestressed beams, built at the workshop in sections, and joined together by means of sixty 7 mm cables in each beam. As the shear forces are more acute at the joints, the end of each section has a kind of diaphragm, to provide a large contact area, and hence greater surface to transmit the shear forces. The methods of construction are also of interest. Briefly, they involve building the bridge piles, and use these to support a provisional structure with transversal movement. This provisional structure, in turn, served as platform for two bridge cranes, which lifted the girders to their final location. After the first span was completed, the deck was concreted and the auxiliary structure pushed forward to the next span, to repeat the same operations. This arrangement saved the use of provisional framework.En este trabajo se describe uno de los tres puentes que Hidrocivil, S. A., ha construido.—previo concurso— en la región catalana; concretamente, el que salva el río Ripoll. Los otros dos no han sido objeto de descripción general por ser muy similares, en lo que a ejecución y concepción se refiere, con la única variante que presentan las características topográficas locales. La empresa propuso ciertas variantes— que fueron aceptadas— en la prefabricación y métodos de construcción. El interés de estas obras se centra en el empleo de vigas pretensadas, prefabricadas en taller por trozos, y solidarizados en el mismo mediante las operaciones

  15. Violencia con el anciano

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    Rita Campillo Motilva

    2002-08-01

    Full Text Available La violencia doméstica es tan antigua como la humanidad misma y se reconocen la violencia infantil, contra la mujer y al anciano, fundamentalmente; siendo este último grupo una población en ascenso por las mayores expectativas de vida de los últimos años. Como resultado de ello, el número de casos de abuso en el anciano se incrementará y el impacto de este abuso sobre la salud debe ser considerado de forma adecuada. La gama de maltratos es variadísima e incluye el abuso físico, emocional, financiero, sexual, por negligencia, negación a brindarle ayuda y otras formas más. Los ancianos con deterioro cognitivo son los más vulnerables. El médico en la atención primaria de salud es un pilar importante en la prevención y educación de este problema.Domestic violence is as old as humanity itself. Child, women and elderly abuse are mainly recognized. The elderly group is increasing due to the higher life expectancy experimented during the last years. As a result, the number of battered elderly will grow and the impact of this abuse on health should be adequately considered. The range of abuse is very wide and it includes physical, emotional, financial and sexual abuse, negligence, rejection to give assistance and others. The elderly with cognitive deterioration are the most vulnerable. The physician at the primary health care level is an important milestone in the prevention and education of this problem.

  16. Potencial terapêutico das células-tronco de medula óssea no tratamento da epilepsia Therapeutic potential of bone marrow stem cells in epilepsy treatment

    Directory of Open Access Journals (Sweden)

    Maria Julia M. Carrion

    2009-05-01

    Full Text Available Epilepsia é uma patologia bastante prevalente no nosso meio. Há um número significativo de pacientes que não obtém resposta com a terapêutica medicamentosa, o que motivou a pesquisa de novas terapêuticas. O conceito de neurogênese no cérebro adulto, hoje já amplamente conhecida, principalmente a que ocorre na zona subventricular e na zona subgranular do giro denteado, motivou o desenvolvimeto de técnicas que aproveitassem esse mecanismo na tentativa de obtenção de efeitos antiepileptogênicos e reparadores. A maior parte dos estudos em vigência hoje, e que buscam tal finalidade, trabalha o uso de transplante de células progenitoras neurais ou de células fetais em modelos experimentais. No entanto, a terapêutica com células-tronco de medula óssea parece bastante interessante e promissora. Em doenças neurológicas nas quais os danos são frequentemente irreversíveis, as estratégias regenerativas podem representar um novo caminho. Em nosso laboratório, temos estudado o potencial terapêutico de células-tronco da medula óssea no controle de crises espontâneas recorrentes associadas ao modelo da pilocarpina com resultados excelentes. Também já está em andamento o primeiro estudo em humanos utilizando células-tronco de medula óssea para o tratatamento da epilepsia.Epilepsy is a prevalent pathology. A significative number of patients do not achieve an adequate response to pharmacological therapy. This observation has motivated the search for new strategies. The now well known concept of neurogenesis in the adult brain, in particular in the subventricular and dentate gyrus subgranular zones, has encouraged the development of strategies that might control this mechanism in order to obtain either antiepileptogenic or repair effects. Most studies focus on the transplantation of neural progenitor or fetal cells in experimental models, although bone marrow stem cell therapy is promising. In neurological diseases in which damage

  17. Estudo da cisticercose em pacientes portadores de epilepsia residentes em municípios do Cariri paraibano Cysticercosis research in epileptic patients dwelling in towns of the western Cariri in the State of Paraíba, Brazil

    Directory of Open Access Journals (Sweden)

    Francisca Inês de Sousa Freitas

    2005-09-01

    Full Text Available Este estudo contou com uma amostra de 110 pacientes epilépticos residentes no Cariri paraibano, tendo sido desenvolvido em três etapas sucessivas. Durante a primeira etapa, aplicou-se a ficha epidemiológica visando identificar fatores de risco associados ao complexo teníase-cisticercose na etiologia da epilepsia dos pacientes. A segunda etapa consistiu em exames imunológicos dos 110 pacientes com a utilização da técnica EITB para a identificação de anticorpos séricos anti-cisticercos, e da técnica ELISA para a presença de antígenos circulantes. Na terceira etapa, treze pacientes com sorologia considerada positiva foram submetidos a exames tomográficos. A partir da aplicação do questionário, foram detectados alguns fatores de risco. A soroprevalência constatada foi 118,2/1000 habitantes. Dos 13 pacientes com sorologia positiva para cisticercose, 46,1% têm lesões sugestivas de cisticercose de localização parenquimatosa. Conclui-se que os municípios estudados apresentam perfil epidemiológico compatível com a ocorrência do complexo teníase-cisticercose e que a cisticercose possivelmente desempenhe papel importante no surgimento da epilepsia nesses pacientes.This research involved a sample of 110 epileptic patients from western Cariri, Paraíba, Brazil and it has been developed in three successive phases. During the first one, an epidemiological form was applied with the aim of identifying risk factors related to the taeniasis cysticercosis complex in the etiology of the patients' epilepsy. The second phase consisted of immunological exams of 110 patients, by means of the EITB technique to identify the anti-cysticerci serum antibodies, whereas the presence of circulating antigens was verified through the ELISA technique. In the third phase, thirteen patients who were seropositive, were submitted to brain CT scan. Applying the questionnaire enabled us to know some risk factors. The seroprevalence detected was 118

  18. The flexible engagement of monitoring processes in non-focal and focal prospective memory tasks with salient cues.

    Science.gov (United States)

    Hefer, Carmen; Cohen, Anna-Lisa; Jaudas, Alexander; Dreisbach, Gesine

    2017-09-01

    Prospective memory (PM) refers to the ability to remember to perform a delayed intention. Here, we aimed to investigate the ability to suspend such an intention and thus to confirm previous findings (Cohen, Gordon, Jaudas, Hefer, & Dreisbach, 2016) demonstrating the ability to flexibly engage in monitoring processes. In the current study, we presented a perceptually salient PM cue (bold and red) to rule out that previous findings were limited to non-salient and, thus, easy to ignore PM cues. Moreover, we used both a non-focal (Experiment 1) and a focal PM (Experiment 2) cue. In both Experiments, three groups of participants performed an Eriksen flanker task as an ongoing task with an embedded PM task (they had to remember to press the F1 key if a pre-specified cue appeared). Participants were assigned to either a control condition (performed solely the flanker task), a standard PM condition (performed the flanker task along with the PM task), or a PM delayed condition (performed the flanker task but were instructed to postpone their PM task intention). The results of Experiment 1 with the non-focal PM cue closely replicated those of Cohen et al. (2016) and confirmed that participants were able to successfully postpone the PM cue intention without additional costs even when the PM cue was a perceptually salient one. However, when the PM cue was focal (Experiment 2), it was much more difficult for participants to ignore it as evidenced by commission errors and slower latencies on PM cue trials. In sum, results showed that the focality of the PM cue plays a more crucial role in the flexibility of the monitoring process whereas the saliency of the PM cue does not. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. Natural-focal diseases: mapping experience in Russia.

    Science.gov (United States)

    Malkhazova, Svetlana M; Mironova, Varvara A; Kotova, Tatiana V; Shartova, Natalia V; Orlov, Dmitry S

    2014-06-14

    Natural-focal diseases constitute a serious hazard for human health. Agents and vectors of such diseases belong to natural landscapes. The aim of this study is to identify the diversity and geography of natural-focal diseases in Russia and to develop cartographic approaches for their mapping, including mathematical-cartographical modeling. Russian medico-geographical mapping of natural-focal diseases is highly developed regionally and locally but extremely limited at the national level. To solve this problem, a scientific team of the Faculty of Geography at Lomonosov Moscow State University has developed and implemented a project of a medico-geographical Atlas of Russia "Natural-Focal Diseases". The mapping is based on medical statistics data. The Atlas contains a series of maps on disease incidence, long-term dynamics of disease morbidity, etc. In addition, other materials available to the authors were used: mapping of the natural environment, field data, archival materials, analyzed satellite images, etc. The maps are processed using ArcGIS (ESRI) software application. Different methods of rendering of mapped phenomena are used (geographical ranges, diagrams, choropleth maps etc.). A series of analytical, integrated, and synthetic maps shows disease incidence in the population at both the national and regional levels for the last 15 years. Maps of the mean annual morbidity of certain infections and maps of morbidity dynamics and nosological profiles allow for a detailed analysis of the situation for each of 83 administrative units of the Russian Federation. The degree of epidemic hazard in Russia by natural-focal diseases is reflected in a synthetic medico-geographical map that shows the degree of epidemic risks due to such diseases in Russia and allows one to estimate the risk of disease manifestation in a given region. This is the first attempt at aggregation and public presentation of diverse and multifaceted information about natural-focal diseases in Russia

  20. CT and ERCP findings of chronic focal pancreatitis

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hee Soo; Lee, Jong Tae; Yoo, Hyung Sik; Kim, Eun Kyeong [Yonsei Univ. College of Medicine, Seoul (Korea, Republic of)

    1996-10-01

    To evaluate the major radiologic features of chronic focal pancreatitis in various imaging studies, with special emphasis on CT and ERCP findings. From 1991 to 1995, twelve patients were pathologically proved to be suffering from focal chronic pancreatitis after pancreatico-duodenectomy;for retrospective evaluation, imaging studies were available for eight(seven men, one woman;mean age 58.9{+-}6.6, range 47 to 67). Clinical, surgical, and radiological findings, including CT(n=8), ultrasound(n=7), ERCP(n=8) and UGI(n=3) were analysed. Seven male patients had suffered from chronic alcoholism for between 20 and 50 years. Serum bilirubin levels were normal in eight patients and alkaline phosphatase levels were normal in seven patients. Serum CA 19-9 levels were normal in all five patients who had undergone preoperative evaluation. Seven patients(87.5%) showed focal enlargement without definable margin on CT, and five of the six lesions detectable on ultrasound(83.3%) were ill defined hypoechoic nodules. Dilated side branches within lesions were seen in five of eight patients(83.3%) on CT and ERCP. Double duct signs were observed in siven(87.5%) patients, and dilated intrahepatic ducts in six(75%), with diameters ranging from 5 to 8mm(average:5.42{+-}1.96mm). The average ratio of pancreatic duct caliber to gland width was 0.33{+-}0.19. None of the patients had calcification within the lesion and one case showed intraductal calcification. None showed perivascular fat obliteration around the superior mesenteric artery or celiac axis. The average biductal distance between abnormal common bile duct and the immediately adjacent pancreatic duct was 4.0{+-}1.15mm. One of three cases who under went a UGI examination showed severe luminal narrowing and mucosal thickening in the second protion of the duodenum, another showed double contour, and the other merely showed widening of the C-loop of the duodenum. Chronic focal pancreatitis mostly demonstrated ill defined focal

  1. CT and ERCP findings of chronic focal pancreatitis

    International Nuclear Information System (INIS)

    Kim, Hee Soo; Lee, Jong Tae; Yoo, Hyung Sik; Kim, Eun Kyeong

    1996-01-01

    To evaluate the major radiologic features of chronic focal pancreatitis in various imaging studies, with special emphasis on CT and ERCP findings. From 1991 to 1995, twelve patients were pathologically proved to be suffering from focal chronic pancreatitis after pancreatico-duodenectomy;for retrospective evaluation, imaging studies were available for eight(seven men, one woman;mean age 58.9±6.6, range 47 to 67). Clinical, surgical, and radiological findings, including CT(n=8), ultrasound(n=7), ERCP(n=8) and UGI(n=3) were analysed. Seven male patients had suffered from chronic alcoholism for between 20 and 50 years. Serum bilirubin levels were normal in eight patients and alkaline phosphatase levels were normal in seven patients. Serum CA 19-9 levels were normal in all five patients who had undergone preoperative evaluation. Seven patients(87.5%) showed focal enlargement without definable margin on CT, and five of the six lesions detectable on ultrasound(83.3%) were ill defined hypoechoic nodules. Dilated side branches within lesions were seen in five of eight patients(83.3%) on CT and ERCP. Double duct signs were observed in siven(87.5%) patients, and dilated intrahepatic ducts in six(75%), with diameters ranging from 5 to 8mm(average:5.42±1.96mm). The average ratio of pancreatic duct caliber to gland width was 0.33±0.19. None of the patients had calcification within the lesion and one case showed intraductal calcification. None showed perivascular fat obliteration around the superior mesenteric artery or celiac axis. The average biductal distance between abnormal common bile duct and the immediately adjacent pancreatic duct was 4.0±1.15mm. One of three cases who under went a UGI examination showed severe luminal narrowing and mucosal thickening in the second protion of the duodenum, another showed double contour, and the other merely showed widening of the C-loop of the duodenum. Chronic focal pancreatitis mostly demonstrated ill defined focal enlargement and

  2. La biopsia estereotáctica en el diagnóstico de las lesiones cerebrales focales en sida Stereotactic brain biopsy in the diagnosis of focal brain lesions in AIDS

    Directory of Open Access Journals (Sweden)

    Marcelo Corti

    2008-08-01

    Full Text Available Las lesiones cerebrales focales constituyen una complicación frecuente en los pacientes con infección por el virus de la inmunodeficiencia humana (HIV y síndrome de inmunodeficiencia adquirida (sida. Durante el período comprendido entre enero de 1999 y mayo de 2007 se realizaron un total de 83 biopsias en pacientes con sida y lesiones cerebrales. Se incluyeron aquellos pacientes que no hubiesen respondido al algoritmo habitual de enfoque diagnóstico-terapéutico de estas lesiones. Todas las muestras obtenidas fueron sometidas a evaluación intraoperatoria para asegurar la obtención de material patológico y posterior análisis histopatológico y exámenes microbiológicos. De los 41 pacientes con lesiones cerebrales múltiples, 62 tenían localización supratentorial, en 4 eran infratentoriales y 17 mostraron ambas localizaciones. Cincuenta y un lesiones seleccionadas como blanco estereotáctico tuvieron refuerzo periférico del contraste. Se obtuvo material histopatológico en el 100% de los procedimientos. El diagnóstico más frecuente fue el de leucoencefalopatía multifocal progresiva (LEMP con 24 casos (29%, seguido del linfoma primario del sistema nervioso central (LPSNC con 19 diagnósticos (23% y de toxoplasmosis en 13 pacientes (15.7%. Se comprobó una relación significativa entre los diagnósticos histopatológicos y la localización de las lesiones y entre los diagnósticos histopatológicos y el comportamiento de las imágenes luego de la administración de la sustancia de contraste. El rédito diagnóstico alcanzó el 90.3% (75 biopsias. La morbiletalidad en esta serie fue de 2.4%. La biopsia cerebral estereotáctica permitió alcanzar el diagnóstico etiológico y adecuar el enfoque terapéutico en la mayoría de los pacientes de esta serie.Focal brain lesions are frequent complications among HIV/AIDS patients. Between January 1999 and May 2007, 83 procedures of stereotactic brain biopsies in HIV/AIDS patients with focal

  3. Características de pacientes con parálisis cerebral atendidos en consulta externa de neuropediatría en un hospital peruano

    Directory of Open Access Journals (Sweden)

    Judith R Vila

    Full Text Available El objetivo del estudio fue describir las características de consulta neurológica y referencia de los niños con parálisis cerebral (PC. Estudio descriptivo retrospectivo. Se evaluaron las historias clínicas de los niños con PC asistentes a consulta externa de la unidad de Neuropediatría del Hospital Nacional Cayetano Heredia entre los años 2011 y 2012. Se incluyeron 81 niños, el 53,1% fueron varones; la PC espástica fue la más frecuente (72,8%, la encefalopatía hipóxico isquémica (28,1% y las malformaciones cerebrales (28,1% fueron las principales causas en neonatos a término. La edad media al momento del diagnóstico fue a los 4,1 ± 3,2 años, la epilepsia fue el motivo más frecuente de consulta neuropediátrica. El 58% fue hospitalizado al menos una vez. El tiempo de espera para ser atendido por terapia física tuvo una mediana de 2 meses (rango intercuartílico = 0,8 - 9. Concluimos que el diagnóstico de PC fue tardío, el tiempo de espera para acceder a la atención especializada fue prolongado. Se requieren protocolos y mayor eficiencia para atender en forma adecuada a los niños con PC.

  4. Oral focal epithelial hyperplasia: report of three cases.

    Science.gov (United States)

    Ghalayani, Parichehr; Tavakoli, Payam; Eftekhari, Mehdi; Haghighi, Mohammad Akhondzadeh

    2015-01-01

    Focal epithelial hyperplasia or Heck's disease is an infrequent asymptomatic condition caused by human papillomavirus types 13 or 32 affecting the mucous membrane of the mouth and is commonly seen in young individuals. Firstly, it was described in Indians and Eskimos, but it exists in various populations. We present three cases of Heck's disease in an Afghan immigrant family group living in Iran that seem to have familial predominance. The disease was identified as oral focal epithelial hyperplasia on the basis of histopathologic and clinical findings. The lesions were reduced significantly after 4 months of good oral hygiene. Dentists should be familiar with the clinical manifestations of these types of lesions that affect the oral cavity. In fact, histopathologic assessment and clinical observation are necessary to establish the diagnosis.

  5. Uncooled infrared focal plane array imaging in China

    Science.gov (United States)

    Lei, Shuyu

    2015-06-01

    This article reviews the development of uncooled infrared focal plane array (UIFPA) imaging in China in the past decade. Sensors based on optical or electrical read-out mechanism were developed but the latter dominates the market. In resistive bolometers, VOx and amorphous silicon are still the two major thermal-sensing materials. The specifications of the IRFPA made by different manufactures were collected and compared. Currently more than five Chinese companies and institutions design and fabricate uncooled infrared focal plane array. Some devices have sensitivity as high as 30 mK; the largest array for commercial products is 640×512 and the smallest pixel size is 17 μm. Emphasis is given on the pixel MEMS design, ROIC design, fabrication, and packaging of the IRFPA manufactured by GWIC, especially on design for high sensitivities, low noise, better uniformity and linearity, better stabilization for whole working temperature range, full-digital design, etc.

  6. Focal points and principal solutions of linear Hamiltonian systems revisited

    Science.gov (United States)

    Šepitka, Peter; Šimon Hilscher, Roman

    2018-05-01

    In this paper we present a novel view on the principal (and antiprincipal) solutions of linear Hamiltonian systems, as well as on the focal points of their conjoined bases. We present a new and unified theory of principal (and antiprincipal) solutions at a finite point and at infinity, and apply it to obtain new representation of the multiplicities of right and left proper focal points of conjoined bases. We show that these multiplicities can be characterized by the abnormality of the system in a neighborhood of the given point and by the rank of the associated T-matrix from the theory of principal (and antiprincipal) solutions. We also derive some additional important results concerning the representation of T-matrices and associated normalized conjoined bases. The results in this paper are new even for completely controllable linear Hamiltonian systems. We also discuss other potential applications of our main results, in particular in the singular Sturmian theory.

  7. Focal sparing around the gallbladder in fatty liver

    International Nuclear Information System (INIS)

    Chen, Kemin; Hiramatsu, Yoshihiro; Yunoki, Masanori; Hirano, Yoko

    1989-01-01

    In evaluating fatty liver with CT, the residual normal liver tissues without fat deposits are occasionally detected on CT as high attenuation regions, especially surrounding the gallbladder. This study examined the incidence of this phenomenon in terms of the diagnostic value of CT in fatty liver. Fifty-seven patients with fatty liver were examined with CT. The incidence of focal sparing area was the highest in the gallbladder bed (42/57, 74%), followed by the interlobar fissure or subcapsular area (13, 23%), quadrate lobe (8, 14%), caudate lobe (2, 4%), and right lobe (one, 1.8%). These CT appearances were of spot, band, ring, and the mixed type. In 38 patients, fatty liver was too moderate to be detected without CT attenuation numbers. Among them, 27 patients (71%) had focal sparing area surrounding the gallbladder. This CT appearance seemed to be of significance in preventing the missing of moderate fatty liver. (Namekawa, K)

  8. Segmented focal plane detector for light and heavy ions

    International Nuclear Information System (INIS)

    Wolfs, F.L.H.; Bryan, D.C.; Kurz, K.L.; Herrick, D.M.; Perera, P.A.A.; White, C.A.

    1992-01-01

    A segmented focal plane detector for an Enge split-pole spectrograph has been developed for the study of breakup reactions at very low relative energies. It consists of a 61 cm long segmented position-sensitive parallel plate avalanche counter backed by a large Bragg curve detector. A segmented plastic scintillator is mounted behind the anode of the Bragg curve detector and is used for particle identification of low-ionizing particles. The dead space between the two sections of the focal plane detector is 2.5 mm. The intrinsic position resolution of the detector is 1 mm. The intrinsic energy resolution depends on the energy of the incident ion and can be as good as 0.55%. The nuclear charge and mass resolutions are 0.3 e and 0.3 u, respectively. (orig.)

  9. Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration.

    Science.gov (United States)

    Wu, Jui-Chung; Chen, Yu-Chen; Kuo, Chih-Ting; Wenshin Yu, Helen; Chen, Yin-Quan; Chiou, Arthur; Kuo, Jean-Cheng

    2015-12-18

    Directed cell migration requires dynamical control of the protein complex within focal adhesions (FAs) and this control is regulated by signaling events involving tyrosine phosphorylation. We screened the SH2 domains present in tyrosine-specific kinases and phosphatases found within FAs, including SRC, SHP1 and SHP2, and examined whether these enzymes transiently target FAs via their SH2 domains. We found that the SRC_SH2 domain and the SHP2_N-SH2 domain are associated with FAs, but only the SRC_SH2 domain is able to be regulated by focal adhesion kinase (FAK). The FAK-dependent association of the SRC_SH2 domain is necessary and sufficient for SRC FA targeting. When the targeting of SRC into FAs is inhibited, there is significant suppression of SRC-mediated phosphorylation of paxillin and FAK; this results in an inhibition of FA formation and maturation and a reduction in cell migration. This study reveals an association between FAs and the SRC_SH2 domain as well as between FAs and the SHP2_N-SH2 domains. This supports the hypothesis that the FAK-regulated SRC_SH2 domain plays an important role in directing SRC into FAs and that this SRC-mediated FA signaling drives cell migration.

  10. A focal plane detector for both light and heavy ions

    International Nuclear Information System (INIS)

    Ophel, T.R.; Johnston, A.

    1978-05-01

    The characteristics of a multi-element, ionization-type focal plane detector with an effective length of 53 cm have been evaluated for various ions ranging between protons and 32 S. The position resolution obtained is typically 1 mm. Excellent energy (0.49% for 16 O) and angular resolution (0.2 degrees with respect to beam direction for 7 Li) have been obtained enabling clean separation of ion species at essentially full angular acceptance of a split-pole spectrograph

  11. Perampanel for focal epilepsy: insights from early clinical experience

    OpenAIRE

    Trinka, E.; Steinhoff, B. J.; Nikanorova, M.; Brodie, M. J.

    2015-01-01

    Perampanel is approved for adjunctive therapy of focal epilepsy with or without secondarily generalized seizures in patients aged >12 years. This narrative review uses real-world and clinical trial data to elucidate perampanel's role in the clinic. Audit data show good tolerability with perampanel and higher freedom-from-seizure rates in elderly vs younger patients. When using perampanel in elderly patients, special attention should be given to comorbidities and co-medication to avoid potenti...

  12. Primary Focal Dystonia: Evidence for Distinct Neuropsychiatric and Personality Profiles

    OpenAIRE

    2009-01-01

    Abstract Background: Primary focal dystonia (PFD) is characterized by motor symptoms. Frequent co-occurrence of abnormal mental conditions has been mentioned for decades but is less well defined. We evaluated prevalence rates of psychiatric disorders, personality disorders and traits in a large cohort of PFD patients. Methods: Prevalence rates of clinical psychiatric diagnoses in 86 PFD patients were compared to a population-based sample (N=3943) using a multiple regress...

  13. The extracellular matrix and altered diffusion in focal cortical dysplasia

    Czech Academy of Sciences Publication Activity Database

    Homola, Aleš; Vargová, Lýdia; Cicanič, Michal; Zámečník, J.; Marusič, P.; Kršek, P.; Syková, Eva

    2011-01-01

    Roč. 59, S1 (2011), S106-S106 ISSN 0894-1491. [European meeting on Glia l Cells in Health and Disease /10./. 13.09.2011-17.09.2011, Prague] R&D Projects: GA MŠk 1M0538; GA ČR GA309/09/1597 Institutional research plan: CEZ:AV0Z50390703 Keywords : focal cortical dysplasia * diffusion * extracellular matrix Subject RIV: FH - Neurology

  14. Atypical Focal Osteomyelitis as Initial Manifestation of AIDS

    OpenAIRE

    A. Akiki; Y. Bilde

    2011-01-01

    Persistent pain development after a skeletal contusion rarely poses the diagnosis of osteomyelitis. We report the case of a fibular head contusion as an initial manifestation of a focal abscess development in a healthy young patient. The traditional treatment of surgical drainage revealed the presence of an atypical Mycobacterium haemophilum isolates in the abscess. This lead to further investigations that concluded and established the diagnosis of AIDS. Conclusion. Isolation of an atypical M...

  15. Explaining focal points: Cognitive hierarchy theory versus team reasoning

    OpenAIRE

    Bardsley, Nicholas; Mehta, Judith; Starmer, Chris; Sugden, Robert

    2008-01-01

    This paper reports experimental tests of two alternative explanations of how players use focal points to select equilibria in one-shot coordination games. Cognitive hierarchy theory explains coordination as the result of common beliefs about players’ pre-reflective inclinations towards the relevant strategies; the theory of team reasoning explains it as the result of the players’ using a non-standard form of reasoning. We report two experiments. One finds strong support for team reasoning; th...

  16. Focal epilepsy with ictal abdominal pain: a case report

    OpenAIRE

    Cerminara, Caterina; El Malhany, Nadia; Roberto, Denis; Curatolo, Paolo

    2013-01-01

    Focal epilepsy with ictal abdominal pain is an unusual partial epilepsy characterized by paroxysmal episodes of abdominal or visceral pain, disturbance of awareness and electroencephalographic abnormalities. We describe a new case of ictal abdominal pain in which gastrointestinal complaints were the only manifestation of seizures and review the previously described pediatric patients. In our patient clinical findings, ictal EEG abnormalities, and a good response to antiepileptic drugs allowed...

  17. Seizure ending signs in patients with dyscognitive focal seizures.

    Science.gov (United States)

    Gavvala, Jay R; Gerard, Elizabeth E; Macken, Mícheál; Schuele, Stephan U

    2015-09-01

    Signs indicating the end of a focal seizure with loss of awareness and/or responsiveness but without progression to focal or generalized motor symptoms are poorly defined and can be difficult to determine. Not recognizing the transition from ictal to postictal behaviour can affect seizure reporting accuracy by family members and may lead to delayed or a lack of examination during EEG monitoring, erroneous seizure localization and inadequate medical intervention for prolonged seizure duration. Our epilepsy monitoring unit database was searched for focal seizures without secondary generalization for the period from 2007 to 2011. The first focal seizure in a patient with loss of awareness and/or responsiveness and/or behavioural arrest, with or without automatisms, was included. Seizures without objective symptoms or inadequate video-EEG quality were excluded. A total of 67 patients were included, with an average age of 41.7 years. Thirty-six of the patients had seizures from the left hemisphere and 29 from the right. All patients showed an abrupt change in motor activity and resumed contact with the environment as a sign of clinical seizure ending. Specific ending signs (nose wiping, coughing, sighing, throat clearing, or laughter) were seen in 23 of 47 of temporal lobe seizures and 7 of 20 extra-temporal seizures. Seizure ending signs are often subtle and the most common finding is a sudden change in motor activity and resumption of contact with the environment. More distinct signs, such as nose wiping, coughing or throat clearing, are not specific to temporal lobe onset. A higher proportion of seizures during sleep went unexamined, compared to those during wakefulness. This demonstrates that seizure semiology can be very subtle and arousals from sleep during monitoring should alert staff. Patient accounts of seizure frequency appear to be unreliable and witness reports need to be taken into account. [Published with video sequences].

  18. Intracoronary infusion of catecholamines causes focal arrhythmias in pigs.

    Science.gov (United States)

    Doppalapudi, Harish; Jin, Qi; Dosdall, Derek J; Qin, Hao; Walcott, Gregory P; Killingsworth, Cheryl R; Smith, William M; Ideker, Raymond E; Huang, Jian

    2008-09-01

    Acute ischemia causes myriad changes including increased catecholamines. We tested the hypothesis that elevated catecholamines alone are arrhythmogenic. A 504 electrode sock was placed over both ventricles in six open-chest pigs. During control infusion of saline through a catheter in the left anterior descending coronary artery (LAD), no sustained arrhythmias occurred, and the refractory period estimated by the activation recovery interval (ARI) was 175 +/- 14 ms in the LAD bed below the catheter. After infusion of isoproterenol at 0.1 microg/kg/min through the catheter, the ARI in this bed was significantly reduced to 109 +/- 10 ms. A sharp gradient of refractoriness of 43 +/- 10 ms was at the border of the perfused bed. Sustained monomorphic ventricular tachycardia occurred after drug infusion in the perfused bed or near its boundary in all animals with a cycle length of 329 +/- 26 ms and a focal origin. The maximum slope of the ARI restitution curve at the focal origins of the tachyarrhythmias was always <1 (0.62 +/- 0.15). Similar results with a focal arrhythmia origin occurred in two additional pigs in which intramural mapping was performed with 36 plunge needle electrodes in the left ventricular perfused bed. Regional elevation of a catecholamine, which is one of the alterations produced by acute ischemia, can by itself cause tachyarrhythmias. These arrhythmias are closely associated with a shortened refractory period and a large gradient of the spatial distribution of refractoriness but not with a steep restitution curve.

  19. [A case of focal epilepsy manifesting multiple psychiatric auras].

    Science.gov (United States)

    Ezura, Michinori; Kakisaka, Yosuke; Jin, Kazutaka; Kato, Kazuhiro; Iwasaki, Masaki; Fujikawa, Mayu; Aoki, Masashi; Nakasato, Nobukazu

    2015-01-01

    We present a case of epilepsy with multiple types of focal seizures that were misdiagnosed as psychiatric disorders. A 20-year-old female patient presented with a variety of episodes, including loss of consciousness, deja vu, fear, delusion of possession, violent movements, and generalized convulsions. Each of these symptoms appeared in a stereotypic manner. She was initially diagnosed with a psychiatric disorder and treated with psychoactive medications, which had no effect. Long-term video electroencephalography revealed that her episodes of violent movement with impaired consciousness and secondarily generalized seizure were epileptic events originating in the right hemisphere. High-field brain magnetic resonance imaging for detecting subtle lesions revealed bilateral lesions from periventricular nodular heterotopia. Her final diagnosis was right hemispheric focal epilepsy. Carbamazepine administration was started, which successfully controlled all seizures. The present case demonstrates the pitfall of diagnosing focal epilepsy when it presents with multiple types of psychiatric aura. Epilepsy should thus be included in differential diagnoses, considering the stereotypic nature of symptoms, to avoid misdiagnosis.

  20. How to diagnose and treat focal therapy failure and recurrence?

    Science.gov (United States)

    Barret, Eric; Harvey-Bryan, Kadi-Ann; Sanchez-Salas, Rafael; Rozet, Francois; Galiano, Marc; Cathelineau, Xavier

    2014-05-01

    Focal therapy presents an alternative option for disease-targeted therapy while preserving erectile and urinary function without compromising oncological outcome. Such treatment, which preserves normal prostate parenchyma, presents a clinical challenge to the urologist, as typical disease surveillance parameters are not as reliable in post-ablation follow-up. We propose an integrated approach to post-ablation surveillance to identify treatment failure as well as recurrence. Post-ablation prostate-specific antigen kinetics, imaging based on multiparametric MRI and control biopsies are the tools currently used to follow patients after focal therapy. Good treatment response is indicated by a negative control biopsy, absence of persistent lesion on post-treatment imaging and a reduction in prostate-specific antigen of at least 50%. When histological evidence of therapeutic failure or recurrence is present, different options of management may be proposed to the patient including active surveillance, focal salvage therapy or radical salvage treatment, depending on the characteristics of the lesion found. A recommended post-ablation surveillance protocol is presented as well as a discussion of management strategies based on the data currently available.

  1. Achromatic Focal Plane Mask for Exoplanet Imaging Coronagraphy

    Science.gov (United States)

    Newman, Kevin Edward; Belikov, Ruslan; Guyon, Olivier; Balasubramanian, Kunjithapatham; Wilson, Dan

    2013-01-01

    Recent advances in coronagraph technologies for exoplanet imaging have achieved contrasts close to 1e10 at 4 lambda/D and 1e-9 at 2 lambda/D in monochromatic light. A remaining technological challenge is to achieve high contrast in broadband light; a challenge that is largely limited by chromaticity of the focal plane mask. The size of a star image scales linearly with wavelength. Focal plane masks are typically the same size at all wavelengths, and must be sized for the longest wavelength in the observational band to avoid starlight leakage. However, this oversized mask blocks useful discovery space from the shorter wavelengths. We present here the design, development, and testing of an achromatic focal plane mask based on the concept of optical filtering by a diffractive optical element (DOE). The mask consists of an array of DOE cells, the combination of which functions as a wavelength filter with any desired amplitude and phase transmission. The effective size of the mask scales nearly linearly with wavelength, and allows significant improvement in the inner working angle of the coronagraph at shorter wavelengths. The design is applicable to almost any coronagraph configuration, and enables operation in a wider band of wavelengths than would otherwise be possible. We include initial results from a laboratory demonstration of the mask with the Phase Induced Amplitude Apodization coronagraph.

  2. Focal lesions in the central nervous system: stereotaxic radioneurosurgery

    International Nuclear Information System (INIS)

    Fabrikant, J.I.; Budinger, T.f.; Hosobuchi, Y.; Born, J.L.; Tobias, C.A.

    1981-01-01

    The application of heavy-ion beams for fundamental and applied brain research has unusual potential. Methods are being developed in our laboratory for producing focal lesions in the central nervous system (e.g., the hypothalamus, thalamus, pituitary gland) to investigate nerve pathways and neuroendocrine responses, and for treating certain pathological disorders of the brain with stereotaxic Bragg peak heavy-ion radiosurgery. Studies in animals are demonstrating the value of this neuroscience tool for investigating mammalian brain response to induction of discrete focal lesions in the hypothalamus or in the cerebral cortex. These studies are also elucidating the neuroendocrinological response follwing ablation of various portions of the midbrain, without requiring complex neurosurgical preparations. Clinical studies are demonstrating the feasibility of stereotaxic neurological radiosurgery for treating certain inoperable vascular disorders of the brain [e.g., arteriovenous malformations (AVM), internal carotid artery-cavernous sinus fistulas and other cerebrovascular disorders] in patients who are already demonstrating progressive neurological deficit. Further applications of focal lesion production with the Bragg ionization peak can be extended to include localized radiation to centers of the brain and spinal cord for treatment of such disorders as Parkinson's disease, pituitary microadenomas, acoustic neuromas, and the control of pain. The eventual application of radioactive beams will provide accurate localization of the stopping points of the beam, thereby making it feasible to stop the beam accurately at a defined depth within the central nervous system

  3. A Micro-Thermal Sensor for Focal Therapy Applications

    Science.gov (United States)

    Natesan, Harishankar; Hodges, Wyatt; Choi, Jeunghwan; Lubner, Sean; Dames, Chris; Bischof, John

    2016-02-01

    There is an urgent need for sensors deployed during focal therapies to inform treatment planning and in vivo monitoring in thin tissues. Specifically, the measurement of thermal properties, cooling surface contact, tissue thickness, blood flow and phase change with mm to sub mm accuracy are needed. As a proof of principle, we demonstrate that a micro-thermal sensor based on the supported “3ω” technique can achieve this in vitro under idealized conditions in 0.5 to 2 mm thick tissues relevant to cryoablation of the pulmonary vein (PV). To begin with “3ω” sensors were microfabricated onto flat glass as an idealization of a focal probe surface. The sensor was then used to make new measurements of ‘k’ (W/m.K) of porcine PV, esophagus, and phrenic nerve, all needed for PV cryoabalation treatment planning. Further, by modifying the sensor use from traditional to dynamic mode new measurements related to tissue vs. fluid (i.e. water) contact, fluid flow conditions, tissue thickness, and phase change were made. In summary, the in vitro idealized system data presented is promising and warrants future work to integrate and test supported “3ω” sensors on in vivo deployed focal therapy probe surfaces (i.e. balloons or catheters).

  4. Fast multifrequency focal beam analysis for 3D seismic acquisition geometry

    NARCIS (Netherlands)

    Wei, W.; Fu, L.; Blacquiere, G.

    2012-01-01

    A method for the efficient computation of multifrequency focal beams for 3D seismic acquisition geometry analysis has been developed. By computing them for all the frequency components of seismic data, single-frequency focal beams can be extended to multifrequency focal beams. However, this

  5. Acne polimorfo: tratamiento con Implacen

    Directory of Open Access Journals (Sweden)

    Rubén Pérez Armas

    1995-06-01

    Full Text Available Se realiza el estudio de 40 pacientes con acné polimorfo, los que fueron atendidos en la Consulta de Dermatología del Hospital Provincial Clinicoquirúrgico Docente "Celia Sánchez Manduley", en el período comprendido de enero de 1988 a diciembre de 1989. Se revisa la literatura médica sobre los diversos métodos y medicamentos utilizados en la terapéutica de esta dermatosis. Se describe el esquema de tratamiento empleado con implacén en 30 pacientes; los 10 restantes se trataron con placebo; se compara dicho esquema con los tradicionales y se observan mejores resultados con nuestro estudio. Se destaca la ausencia de recaídas, así como el resultado del tratamiento de acuerdo con el sexo.A study was performed in 40 patients presenting with polymorphic acne who were attended in the Dermatology Department of "Celia Sánchez Manduley" Clinicosurgical and Teaching Hospital from January, 1988 to December, 1989. A review of the literature was made seeking for the different methods and drugs used for the treatment of this dermatosis. The treatment schedule with the use of implacen in 30 patients is described. Such therapeutic schedule was compared with traditional ones and better results were observed with the use of implacen. The fact that there were no relapses is highlighted, as well as the result of treatment according to sex.

  6. HIGH PERFORMANCE PIAA CORONAGRAPHY WITH COMPLEX AMPLITUDE FOCAL PLANE MASKS

    International Nuclear Information System (INIS)

    Guyon, Olivier; Martinache, Frantz; Belikov, Ruslan; Soummer, Remi

    2010-01-01

    We describe a coronagraph approach where the performance of a Phase-Induced Amplitude Apodization (PIAA) coronagraph is improved by using a partially transmissive phase-shifting focal plane mask and a Lyot stop. This approach combines the low inner working angle offered by phase mask coronagraphy, the full throughput and uncompromized angular resolution of the PIAA approach, and the design flexibility of Apodized Pupil Lyot Coronagraph. A PIAA complex mask coronagraph (PIAACMC) is fully described by the focal plane mask size, or, equivalently, its complex transmission which ranges from 0 (opaque) to -1 (phase shifting). For all values of the transmission, the PIAACMC theoretically offers full on-axis extinction and 100% throughput at large angular separations. With a pure phase focal plane mask (complex transmission = -1), the PIAACMC offers 50% throughput at 0.64 λ/D while providing total extinction of an on-axis point source. This performance is very close to the 'fundamental performance limit' of coronagraphy derived from first principles. For very high contrast level, imaging performance with PIAACMC is in practice limited by the angular size of the on-axis target (usually a star). We show that this fundamental limitation must be taken into account when choosing the optimal value of the focal plane mask size in the PIAACMC design. We show that the PIAACMC enables visible imaging of Jupiter-like planets at ∼1.2 λ/D from the host star, and can therefore offer almost three times more targets than a PIAA coronagraph optimized for this type of observation. We find that for visible imaging of Earth-like planets, the PIAACMC gain over a PIAA is probably much smaller, as coronagraphic performance is then strongly constrained by stellar angular size. For observations at 'low' contrast (below ∼ 10 8 ), the PIAACMC offers significant performance enhancement over PIAA. This is especially relevant for ground-based high contrast imaging systems in the near-IR, where

  7. Electrophysiological and pathological study of focal cortical dysplasia

    International Nuclear Information System (INIS)

    Hodozuka, Akira; Hashizume, Kiyotaka; Hayashi, Yoshimitsu; Tanaka, Tatsuya

    2008-01-01

    Clinical and experimental studies on focal cortical dysplasia (FCD) were carried out. For the experimental study, an experimental FCD model of rats was developed. Twenty Wistar rats at 0-2 days after birth were used for the study. Kainic acid (KA) solution was injected stereotaxically into medial and lateral sites of the sensori-motor cortex. Bipolar electrodes were inserted. The behavior of the rats and electroencephalography (EEG) were recorded using a digital video-EEG monitoring system. After observation periods of 1, 2 and 6 months, the rats were perfused for pathological study. FCD was observed adjacent to the site of KA injection in all rats more than one month after the injection. EEG recording demonstrated focal spike discharges in and around the site of injection. However, clinical seizure was not observed. Pathological studies showed decrease in gamma aminobutyric acid (GABA)-A receptors and increase in GABA-B receptors not only in the lesion but also in perilesional areas. Fifteen surgical cases of FCD with intractable epilepsy were included in the clinical study. Neuro-imaging studies including high-resolution MRI and single photon emission computed tomography (SPECT) were performed. Conventional EEG studies demonstrated focal EEG abnormalities with epileptic phenomena. At surgery, intraoperative electrocorticography (ECoG) was performed in order to localize epileptic foci under neuroleptanalgesia. Fourteen patients showed epileptiform discharges on preresection ECoG. All foci in non-eloquent areas were resected. Pathological studies including immunohistochemical staining were performed, and characteristics of the FCD in relation to EEG findings were analyzed. Electrophysiological examination revealed epileptogenecity not only in the lesions but also in perilesional areas. In the lesions, immunohistochemical studies showed decrease in GABA-A receptors and increase in GABA-B receptors in both the lesions and perilesional areas, but N

  8. Propiedades psicométricas de una herramienta de evaluación para las redes focales de adolescentes infractores de ley*

    Directory of Open Access Journals (Sweden)

    Jaime Muñoz Vidal

    2017-08-01

    Full Text Available El grupo de pares constituye uno de los espacios relacionales más importantes en la adolescencia. Si la red de pares con la que un adolescente cuenta, practica conductas riesgosas, se constituye en un factor de riesgo para que dicho adolescente también las realice. Este estudio tuvo por objetivo la validación de un instrumento de evaluación de las redes focales de adolescentes (Inventario de Recursos Sociocomunitarios centrado en las Redes Focales del/la adolescente o IRS-F. Constituye un estudio de tipo cuantitativo, y utiliza pruebas de correlación, comparación de medias y análisis de confiabilidad. La muestra fue de 138 adolescentes infractores de ley, entre 14 y 19 años, con una media de 16,4 (SD=1,10, residentes en el sur de Chile. Se indaga en la confiabilidad interjueces y consistencia interna (Alpha de Cronbach de 0,790 y 0,868 en sus dos escalas, y se obtienen indicadores adecuados de validez concurrente y discriminante. Los resultados, en general, son consistentes con los encontrados en la literatura internacional.

  9. Formation of multiple focal spots using a high NA lens with a complex spiral phase mask

    Science.gov (United States)

    Lalithambigai, K.; Anbarasan, P. M.; Rajesh, K. B.

    2014-07-01

    The formation of a transversally polarized beam by transmitting a tightly focused double-ring-shaped azimuthally polarized beam through a complex spiral phase mask and high numerical aperture lens is presented based on vector diffraction theory. The generation of transversally polarized focal spot segment splitting and multiple focal spots is illustrated numerically. Moreover, we found that a properly designed complex spiral phase mask can move the focal spots along the optical axis in the z direction. Therefore, one can achieve a focal segment of two, three or multiple completely transversely polarized focal spots, which finds applications in optical trapping and in material processing technologies.

  10. con mala calidad de vida

    Directory of Open Access Journals (Sweden)

    Agustín Martín-Rodríguez

    2007-01-01

    Full Text Available En este estudio ex post facto se ha analizado si los familiares de pacientes con mala calidad de vida presentan diferencias en las variables clínicas de personalidad y relaciones familiares en función de que el paciente haya estado o no ingresado en una Unidad de Cuidados Intensivos. Seleccionamos dos grupos: 29 familiares de pacientes traumatizados graves transcurridos cuatro años de su ingreso en una UCI de Traumatología y con mala calidad de vida (debido a secuelas físicas y/o psicológicas tras el ingreso, tales como traumatismos craneoencefálicos, politraumatismos y tetraplejias traumáticas y 32 familiares de pacientes con mala calidad de vida con cuatro años de evolución de su enfermedad física (hipertensión, diabetes, artritis reumatoide y síndrome de intestino irritable que no han estado ingresados en la UCI. Para alcanzar nuestro objetivo empleamos una Encuesta Psicosocial y los siguientes instrumentos: Cuestionario de Análisis Clínico, Escala de Clima Social en la Familia y Escala de Adaptación Psicosocial de la Enfermedad. Los resultados mostraron que los familiares de pacientes con mala calidad de vida que estuvieron ingresados en la UCI hace cuatro años, presentan diferencias significativas en las variables agitación y expresividad comparados con los familiares de pacientes con mala calidad de vida que no han estado ingresados en la UCI.

  11. Estudio de los circuitos neuronales responsables de ritmopatías y déficit cognitivo en modelos experimentales de epilepsia del lóbulo temporal

    OpenAIRE

    Valero García, Manuel

    2017-01-01

    En periodos de inmovilidad y sueño de ondas lentas emerge en el hipocampo el patrón de actividad más síncrono del cerebro de mamífero: los eventos sharp wave (SPW-r). Gran número de trabajos han demostrado que el reclutamiento celular durante tales eventos recopila secuencias neuronales computacionalmente relevantes, fenómeno que subyace al proceso de consolidación de la memoria. Todas las condiciones que cursan con déficit cognitivos han sido asociadas a alteraciones en los SPW-r, incluyendo...

  12. 'Focal thyroid inferno' on color Doppler ultrasonography: A specific feature of focal Hashimoto's thyroiditis

    Energy Technology Data Exchange (ETDEWEB)

    Fu, Xianshui, E-mail: fuxs1968@163.com [Department of Ultrasound, Peking University Third Hospital, 49 Huayuanbeilu Road, Beijing 100191 (China); Guo, Limei, E-mail: guolimei@bjmu.edu.cn [Department of Pathology, Peking University Third Hospital, 49 Huayuanbeilu Road, Beijing 100191 (China); Zhang, Huabin, E-mail: huabinzhang@bjmu.edu.cn [Department of Ultrasound, Peking University Third Hospital, 49 Huayuanbeilu Road, Beijing 100191 (China); Ran, Weiqiang, E-mail: ranwq-sina@vip.sina.com [Department of Ultrasound, Peking University Third Hospital, 49 Huayuanbeilu Road, Beijing 100191 (China); Fu, Peng, E-mail: fupeng01@gmail.com [Department of Ultrasound, Peking University Third Hospital, 49 Huayuanbeilu Road, Beijing 100191 (China); Li, Zhiqiang, E-mail: lizhq126@126.com [Department of Ultrasound, Peking University Third Hospital, 49 Huayuanbeilu Road, Beijing 100191 (China); Chen, Wen, E-mail: wendy7989@sina.com [Department of Ultrasound, Peking University Third Hospital, 49 Huayuanbeilu Road, Beijing 100191 (China); Jiang, Ling, E-mail: papayaling@yahoo.com.cn [Department of Ultrasound, Peking University Third Hospital, 49 Huayuanbeilu Road, Beijing 100191 (China); Wang, Jinrui, E-mail: jinrui_wang@sina.com [Department of Ultrasound, Peking University Third Hospital, 49 Huayuanbeilu Road, Beijing 100191 (China); Jia, Jianwen, E-mail: drjia88@sohu.com [Department of Ultrasound, Peking University Third Hospital, 49 Huayuanbeilu Road, Beijing 100191 (China)

    2012-11-15

    Purpose: To evaluate color-Doppler features predictive of focal Hashimoto's thyroiditis. Materials and methods: A total of 521 patients with 561 thyroid nodules that underwent surgeries or gun biopsies were included in this study. These nodules were divided into three groups: focal Hashimoto's thyroiditis (104 nodules in 101 patients), benignity other than focal Hashimoto's thyroiditis (73 nodules in 70 patients), and malignancy (358 nodules in 350 patients). On color Doppler sonography, four vascularity types were determined as: hypovascularity, marked internal flow, marked peripheral flow and focal thyroid inferno. The {chi}{sup 2} test was performed to seek the potential vascularity type with the predictive ability of certain thyroid pathology. Furthermore, the gray-scale features of each nodule were also studied. Results: The vascularity type I (hypovascularity) was more often seen in focal Hashimoto's thyroiditis than other benignity and malignancy (46% vs. 20.5% and 19%). While the type II (marked internal flow) showed the opposite tendency (26.9% [focal Hashimoto's thyroiditis] vs. 45.2% [other benignity] and 52.8% [malignancy]). However, type III (marked peripheral flow) was unable to predict any thyroid pathology. Importantly, type IV (focal thyroid inferno) was exclusive to focal Hashimoto's thyroiditis. All 8 type IV nodules appeared to be solid, hypoechoic, and well-defined. Using 'focal thyroid inferno' as an indicator of FHT, the diagnostic sensitivity and specificity were 7.7% and 100% respectively. Conclusions: The vascularity type of 'focal thyroid inferno' is specific for focal Hashimoto thyroiditis. Recognition of this particular feature may avoid unnecessary interventional procedures for some solid hypoechoic thyroid nodules suspicious of malignancy.

  13. Contrubución de la técnica del grupo focal al acercamiento a la percepción estudiantil sobre accesibilidad en el entorno universitario

    Directory of Open Access Journals (Sweden)

    Gross Martínez, Martha

    2015-01-01

    Full Text Available Este artículo describe la técnica de grupo focal utilizada en la investigación: “Accesibilidad en la permanencia de estudiantes con necesidades educativas asociadas o no a discapacidad: Sede Rodrigo Facio” de la Universidad de Costa Rica; cuyo objetivo general consistió en la elaboración de una guía de comprobación y buenas prácticas en el tema de accesibilidad, como un recurso que le permita a la comunidad universitaria dar respuesta a esta población y constituirse en insumo para la construcción de una universidad inclusiva. A partir de los grupos focales, se exploró la percepción estudiantil con necesidades educativas asociadas o no a discapacidad, sobre la accesibilidad en la vida universitaria; para ello esta se caracterizó y categorizó en tres dimensiones: accesibilidad al espacio físico, a la información y al proceso educativo. Esta técnica permitió que cada participante expresara sus percepciones, comentara su vivencia e interacción con el entorno universitario. Finalmente, se concluye que los grupos focales constituyen una técnica relevante de recolección de información en los procesos de investigación cualitativa, porque establecen un acercamiento personal, lo que la convierte en un recurso útil para conocer a esta población

  14. Sistema colinérgico: revisitando receptores, regulação e a relação com a doença de Alzheimer, esquizofrenia, epilepsia e tabagismo Colinergic system: revisiting receptors, regulation and the relationship with Alzheimer disease, schizophrenia, epilepsy and smoking

    OpenAIRE

    Ana L. M. Ventura; Paula A. Abreu; Rodrigo C. C. Freitas; Plínio C. Sathler; Natália Loureiro; Helena C. Castro

    2010-01-01

    OBJETIVO: Revisar a estrutura e o funcionamento do sistema colinérgico central ressaltando seu papel na fisiologia e na fisiopatologia das doenças de Alzheimer e Parkinson, esquizofrenia, epilepsia e tabagismo. MÉTODO: Foi realizada uma pesquisa bibliográfica no MedLine, LILACS, PubMed e ISI, e na Biblioteca da Fundação Oswaldo Cruz, RJ, selecionando-se o período de 1914 a 2009, utilizando os descritores: "receptors", "cholinergic", "Alzheimer disease", "schizophrenia", "epilepsy" e "smoking"...

  15. Prevalence of epilepsy and seizure disorders as causes of apparent life- threatening event (ALTE in children admitted to a tertiary hospital Prevalência de epilepsia e crises epilépticas como causa de eventos com aparente risco de vida (ALTE em crianças internadas em hospital terciário

    Directory of Open Access Journals (Sweden)

    Alessandra Marques dos Anjos

    2009-09-01

    Full Text Available OBJECTIVE: To determine the prevalence and describe clinical characteristics of seizure disorders and epilepsy as causes of apparent life- threatening event (ALTE in children admitted at the emergency and followed in a tertiary hospital. METHOD: Cross-sectional study with prospective data collection using specific guidelines to determine the etiology of ALTE. RESULTS: During the study, 30 (4.2% children admitted to the hospital had a diagnosis of ALTE. There was a predominance of males (73% and term infants (70%. Neonatal neurological disorders and neuropsychomotor development delay were found respectively in 13.4% and 10% of the cases. Etiological investigation revealed that 50% of the cases were idiopathic, and 13.4% were caused by epilepsy or seizure disorders. Although all patients had recurrent ALTE events, epilepsy had not been previously suspected. CONCLUSION: Epilepsy should be included in the differential diagnosis of ALTE, particularly when events are recurrent.OBJETIVO: Determinar a prevalência e características clínicas de crises epilépticas e epilepsia como causa de eventos com aparente risco de vida (ALTE em crianças atendidas na emergência e acompanhadas em hospital terciário. MÉTODO: Estudo transversal com coleta prospectiva de dados através de protocolo específico para identificação da etiologia de ALTE. RESULTADOS: Foram diagnosticadas 30 crianças com ALTE perfazendo 4.2% das crianças internadas no período do estudo. Houve predominância no sexo masculino (73% e em neonatos a termo (70%. História prévia de doenças neurológicas no período neonatal e atraso no desenvolvimento neuropsicomotor ocorreram respectivamente em 13.4% e 10% dos casos. A investigação etiológica identificou 13.4% dos casos relacionados a epilepsia ou crise convulsivas e 50% idiopáticos. Apesar destes pacientes terem apresentados episódios recorrentes em nenhum caso havia a suspeita prévia de epilepsia. CONCLUSÃO: Ao investigar

  16. FOCAL EPILEPTIC MYOCLONUS IN KOZHEVNIKOV–RASMUSSEN SYNDROME

    Directory of Open Access Journals (Sweden)

    N. E. Kvaskova

    2016-01-01

    Full Text Available The article presents the clinical, electroencephalographic (EEG and neuroimaging features, as well as the results of treatment of patients with focal epileptic myoclonus (FEM with the Kozhevnikov–Rasmussen syndrome (KRS. FEM in KRS-patients was identified in 11 cases, accounting for 0.9 % of all the cases of epilepsy with the onset of seizures up to 18 years (n = 1261. The age at onset of KRS ranged from 3 to 21 years (average – 9.2 ± 5.7 years. In the active period of the disease of all patients in the clinical picture the active FEM appeared and increasing frequency of the secondary generalized seizures (SGS. In addition SGS and FEM, the clinical picture of the disease in most patients (91 % the focal motor (clonic and the somatosensory focal seizures were observed. As the disease progressed, the FEM became more pronounced in frequency and intensity, seized more muscle groups, localizing mainly in the muscles of the trunk and limbs. The typical EEG pattern of FEM patients with KRS was regional epileptiform activity that occurs in the structure of the continued regional slowing localizing maximum of the fronto-central-temporal region. During the magnetic resonance tomography of the brain in dynamics all the patients observed the increase in total cortical hemiatrophy. In all the cases, the appointment of antiepileptic therapy resulted in a slowing of the FEM, however, a complete remission was reached at none of the patients. Two patients were made surgical treatment of epilepsy. In one case remission of epileptic seizures was observed after right-side hemispherotomy. Our study showed that FEM is very resistant type of epileptic seizures. This fact calls for the identification of the FEM at the early stages of the disease with the purpose to improve the prognosis, as well as for an earlier surgical treatment.

  17. Temperament and character properties of primary focal hyperhidrosis patients

    Directory of Open Access Journals (Sweden)

    Ak Mehmet

    2013-01-01

    Full Text Available Abstract Background Primary focal hyperhidrosis is a health problem, which has negative effects on the patient's quality of life and significantly affects the patients’ daily activities, social and business life. The aim of this study is to evaluate temperament and character properties of patients diagnosed with primary focal hyperhidrosis. Methods Fifty-six primary focal hyperhidrosis (22.42 ± 7.80 and 49 control subjects (24.48 ± 5.17 participated in the study. Patients who met the diagnostic criteria for PFH were referred to psychiatry clinic where the subjects were evaluated through Structured Clinical Interview for DSM Disorders-I and Temperament and Character Inventory. Results In order to examine the difference between the PFH and control group in terms of temperament and character properties, one-way Multivariate Analysis of Variance (MANOVA was conducted. In terms of temperament properties, PFH group took significantly higher scores than control group in Fatigability and asthenia dimension. In terms of character properties, PFH group scored significantly lower than control group in Purposefulness , Resourcefulness , Self-Directedness and scored significantly higher than control group in Self-forgetfulness and Self-Transcendence. Conclusion Temperament and character features of PFH patients were different from healthy group and it was considered that these features were affected by many factors including genetic, biological, environmental, socio-cultural elements. During the follow-up of PFH cases, psychiatric evaluation is important and interventions, especially psychotherapeutic interventions can increase the chances of success of the dermatological treatments and can have a positive impact on the quality of life and social cohesion of chronic cases.

  18. Reperfusion promotes mitochondrial dysfunction following focal cerebral ischemia in rats.

    Directory of Open Access Journals (Sweden)

    Jun Li

    Full Text Available BACKGROUND AND PURPOSE: Mitochondrial dysfunction has been implicated in the cell death observed after cerebral ischemia, and several mechanisms for this dysfunction have been proposed. Reperfusion after transient cerebral ischemia may cause continued and even more severe damage to the brain. Many lines of evidence have shown that mitochondria suffer severe damage in response to ischemic injury. The purpose of this study was to observe the features of mitochondrial dysfunction in isolated mitochondria during the reperfusion period following focal cerebral ischemia. METHODS: Male Wistar rats were subjected to focal cerebral ischemia. Mitochondria were isolated using Percoll density gradient centrifugation. The isolated mitochondria were fixed for electron microscopic examination; calcium-induced mitochondrial swelling was quantified using spectrophotometry. Cyclophilin D was detected by Western blotting. Fluorescent probes were used to selectively stain mitochondria to measure their membrane potential and to measure reactive oxidative species production using flow cytometric analysis. RESULTS: Signs of damage were observed in the mitochondrial morphology after exposure to reperfusion. The mitochondrial swelling induced by Ca(2+ increased gradually with the increasing calcium concentration, and this tendency was exacerbated as the reperfusion time was extended. Cyclophilin D protein expression peaked after 24 hours of reperfusion. The mitochondrial membrane potential was decreased significantly during the reperfusion period, with the greatest decrease observed after 24 hours of reperfusion. The surge in mitochondrial reactive oxidative species occurred after 2 hours of reperfusion and was maintained at a high level during the reperfusion period. CONCLUSIONS: Reperfusion following focal cerebral ischemia induced significant mitochondrial morphological damage and Ca(2+-induced mitochondrial swelling. The mechanism of this swelling may be mediated by

  19. Kalman Filter for Calibrating a Telescope Focal Plane

    Science.gov (United States)

    Kang, Bryan; Bayard, David

    2006-01-01

    The instrument-pointing frame (IPF) Kalman filter, and an algorithm that implements this filter, have been devised for calibrating the focal plane of a telescope. As used here, calibration signifies, more specifically, a combination of measurements and calculations directed toward ensuring accuracy in aiming the telescope and determining the locations of objects imaged in various arrays of photodetectors in instruments located on the focal plane. The IPF Kalman filter was originally intended for application to a spaceborne infrared astronomical telescope, but can also be applied to other spaceborne and ground-based telescopes. In the traditional approach to calibration of a telescope, (1) one team of experts concentrates on estimating parameters (e.g., pointing alignments and gyroscope drifts) that are classified as being of primarily an engineering nature, (2) another team of experts concentrates on estimating calibration parameters (e.g., plate scales and optical distortions) that are classified as being primarily of a scientific nature, and (3) the two teams repeatedly exchange data in an iterative process in which each team refines its estimates with the help of the data provided by the other team. This iterative process is inefficient and uneconomical because it is time-consuming and entails the maintenance of two survey teams and the development of computer programs specific to the requirements of each team. Moreover, theoretical analysis reveals that the engineering/ science iterative approach is not optimal in that it does not yield the best estimates of focal-plane parameters and, depending on the application, may not even enable convergence toward a set of estimates.

  20. Brivaracetam: a novel antiepileptic drug for focal-onset seizures.

    Science.gov (United States)

    Stephen, Linda J; Brodie, Martin J

    2018-01-01

    Brivaracetam (BRV), the n -propyl analogue of levetiracetam (LEV), is the latest antiepileptic drug (AED) to be licensed in Europe and the USA for the adjunctive treatment of focal-onset seizures with or without secondary generalization in patients aged 16 years or older. Like LEV, BRV binds to synaptic vesicle protein 2A (SV2A), but BRV has more selective binding and a 15- to 30-fold higher binding affinity than LEV. BRV is more effective than LEV in slowing synaptic vesicle mobilization and the two AEDs may act at different binding sites or interact with different conformational states of the SV2A protein. In animal models, BRV provides protection against focal and secondary generalized seizures and has significant anticonvulsant effects in genetic models of epilepsy. The drug undergoes first-order pharmacokinetics with an elimination half-life of 7-8 h. Although BRV is metabolized extensively, the main circulating compound is unchanged BRV. Around 95% of metabolites undergo renal elimination. No dose reduction is required in renal impairment, but it is recommended that the daily dose is reduced by one-third in hepatic dysfunction that may prolong half-life. BRV has a low potential for drug interactions. The efficacy and tolerability of adjunctive BRV in adults with focal-onset seizures have been explored in six randomized, placebo-controlled studies. These showed significant efficacy outcomes for doses of 50-200 mg/day. The most common adverse events reported were headache, somnolence, dizziness, fatigue and nausea. Patients who develop psychiatric symptoms with LEV appear to be at risk of similar side effects with BRV, although preliminary data suggest that these issues are likely to be less frequent and perhaps less severe. As with all AEDs, a low starting dose and slow titration schedule help to minimize side effects and optimize seizure control and thereby quality of life.

  1. Near infrared focal plane for the ISOCAM camera

    International Nuclear Information System (INIS)

    Epstein, G.; Stefanovitch, D.; Tiphene, D.; Carpentier, Y.; Lorans, D.

    1988-01-01

    ISOCAM is one of the science instruments in the Infrared Space Observatory. It is a 2-channel IR Astronomical Imager intended to observe at very low flux levels, thanks to the use of a liquid helium cooled telescope. This paper describes the Focal Plane Assembly design of the short wavelength channel. The operation of a 32 x 32 InSb CID-SAT array detector has been demonstrated. The problems encountered in the design of the cooled electronics and the component selection process are discussed in the light of specific ISO constraints, such as thermal control and radiation shielding. 6 references

  2. Modeling characterization of the National Ignition Facility focal spot

    International Nuclear Information System (INIS)

    Williams, W.H.

    1998-01-01

    The predicted focal spot size of the National Ignition Facility laser is parameterized against the finish quality of the optics in the system. Results are reported from simulations which include static optics aberrations, as well as pump-induced distortions, beam self-focusing, and the effect of an adaptive optic. The simulations do not include contributions from optics mounting errors, residual thermal noise in laser slabs from previous shots, air turbulence, a kinoform phase plate, or smoothing by spectral dispersion (SSD). Consequently, these results represent ''first shot of the day'', without-SSD, predictions

  3. Difficulties in the interpretation of focal changes on liver scans

    Energy Technology Data Exchange (ETDEWEB)

    Derimanov, S.G. (Oblastnoj Onkologicheskij Dispanser, Veliko-Tyrnovo (Bulgaria))

    1983-01-01

    A series of cases are presented in which erroneous conclusions were arrived at by liver scans. The analysis of these errors has shown that they are determined by the similarity of a scanographic picture of focal changes in various diseases of the liver (cancer, cirrhosis, echinococcus, etc.) and the adjacent organs (bronchogenic cyst, renal tumor, etc.). In this connection all attempts to determine the etiology of a pathological process by liver scans without correlation with the results of multidimensional examination frequently result in errors.

  4. Focal dystonia in musicians: From phenomenology to therapy

    Directory of Open Access Journals (Sweden)

    Hans-Christian Jabusch

    2006-01-01

    Full Text Available Background: Musician's dystonia is a task-specific movement disorder which manifests itself as a loss of voluntary motor control in extensively trained movements. In many cases, the disorder terminates the careers of affected musicians. Approximately 1% of all professional musicians are affected.Etiology and Pathophysiology: The pathophysiology of the disorder is still unclear. Findings include (a reduced inhibition in different levels of the central nervous system, (b maladaptive plasticity, e.g. in the somatosensory cortex and in the basal ganglia, and (c alterations in sensorimotor processing. Epidemiological data demon-strated a higher risk for those musicians who play instruments requiring maximal fine-motorskills. For instruments where workload differs across hands, focal dystonia appears more often in the more intensely used hand. In psychological studies, musicians with dystonia had more perfectionist tendencies than healthy musicians. These findings streng then the assumption that behavioral factors may be involved in the etiology of musician's dystonia. Hereditary factors may play a greater role than previously assumed. Preliminary findings suggest a genetic contributiont o focal task-specific dystonia with phenotypic variations including musician's dystonia.Treatment: Treatment options for musician's dystonia include pharmacological interventions such as administration of Trihexyphenidyl or Botulinum Toxin-A as well as retraining programs and ergonomic changes in the instrument. A long-term follow-up study was performed in 144 patients with musician's dystonia. The outcome was revealed on average 8.4 years after onset of symptoms. Outcome was assessed by patients' subjective rating of cumulative treatmentresponse and response to individual therapies. Seventy-seven patients (54% reported an alleviation of symptoms: 33% of the patients with Trihexyphenidyl, 49% with Botulinum Toxin, 50% with pedagogical retraining, 56% with unmonitored

  5. Immunogenic hyperthyroidism following radioiodine ablation of focal autonomy

    International Nuclear Information System (INIS)

    Boddenberg, B.; Voth, E.; Schicha, H.

    1993-01-01

    Immunogenic hyperthyroidism rarely develops after radioiodine elimination of focal autonomous thyroid tissue. We observed this phenomenon in 8 patients between 1989 and 1992. The occurrence of immunogenic hyperthyroidism shortly after elimination of autonomous nodules has not been studied nor is it properly understood. Most studies known today describe the development of autonomous nodules in the course of immunogenic hyperthyroidism or ignore the chronologic order of occurrence. The possibility that immunogenic hyperthyroidism may occur after radioiodine therapy of autonomous nodules, makes a consequent follow-up within the first year following radioiodine therapy mandatory. (orig.) [de

  6. New focal plane detector system for the broad range spectrometer

    International Nuclear Information System (INIS)

    Sjoreen, T.P.

    1984-01-01

    A focal plane detector system consisting of a vertical drift chamber, parallel plate avalanche counters, and an ionization chamber with segmented anodes has been installed in the Broad Range Spectrometer at the Holifield Facility at Oak Ridge. The system, which has been designed for use with light-heavy ions with energies ranging from 10 to 25 MeV/amu, has a position resolution of approx. 0.1 mm, a scattering angle resolution of approx. 3 mrad, and a mass resolution of approx. 1/60

  7. Focal cemento-osseous dysplasia masquerading as a residual cyst.

    Science.gov (United States)

    Bhandari, Rajat; Sandhu, Simarpreet V; Bansal, Himanta; Behl, Rashi; Bhullar, Ramanpreet Kaur

    2012-04-01

    Focal cemento-osseous dysplasia (FCOD) is a benign fibroosseous condition that can be seen in dentulous and edentulous patients. It is an asymptomatic lesion and needs no treatment; however, follow-up is essential due to the possibility that it can progress to a condition called florid cemento-osseous dysplasia. We report a case of FCOD of mandible in a 25-year-old female. Clinically, the lesion resembled periapical pathosis of odontogenic origin. An attempt has been made to discuss the clinical and histopathologic features along with differential diagnosis of cemento-osseous dysplasia.

  8. Focal cemento-osseous dysplasia masquerading as a residual cyst

    Directory of Open Access Journals (Sweden)

    Rajat Bhandari

    2012-01-01

    Full Text Available Focal cemento-osseous dysplasia (FCOD is a benign fibroosseous condition that can be seen in dentulous and edentulous patients. It is an asymptomatic lesion and needs no treatment; however, follow-up is essential due to the possibility that it can progress to a condition called florid cemento-osseous dysplasia. We report a case of FCOD of mandible in a 25-year-old female. Clinically, the lesion resembled periapical pathosis of odontogenic origin. An attempt has been made to discuss the clinical and histopathologic features along with differential diagnosis of cemento-osseous dysplasia.

  9. Slow Activity in Focal Epilepsy During Sleep and Wakefulness

    DEFF Research Database (Denmark)

    Pellegrino, Giovanni; Tombini, Mario; Curcio, Giuseppe

    2017-01-01

    Introduction We aimed to test differences between healthy subjects and patients with respect to slow wave activity during wakefulness and sleep. Methods Fifteen patients affected by nonlesional focal epilepsy originating within temporal areas and fourteen matched controls underwent a 24-hour EEG....... The effect was widespread for alpha band and above, while localized over the affected hemisphere for delta (sleep cycle 1, P = .006; sleep cycle 2, P = .008; sleep cycle 3, P = .017). The analysis of interhemispheric differences showed that the only frequency band stronger over the affected regions...

  10. Focal plane array with modular pixel array components for scalability

    Science.gov (United States)

    Kay, Randolph R; Campbell, David V; Shinde, Subhash L; Rienstra, Jeffrey L; Serkland, Darwin K; Holmes, Michael L

    2014-12-09

    A modular, scalable focal plane array is provided as an array of integrated circuit dice, wherein each die includes a given amount of modular pixel array circuitry. The array of dice effectively multiplies the amount of modular pixel array circuitry to produce a larger pixel array without increasing die size. Desired pixel pitch across the enlarged pixel array is preserved by forming die stacks with each pixel array circuitry die stacked on a separate die that contains the corresponding signal processing circuitry. Techniques for die stack interconnections and die stack placement are implemented to ensure that the desired pixel pitch is preserved across the enlarged pixel array.

  11. Subdural Empyema Presenting with Seizure, Confusion, and Focal Weakness

    Directory of Open Access Journals (Sweden)

    David I Bruner

    2012-12-01

    Full Text Available While sinusitis is a common ailment, intracranial suppurative complications of sinusitis are rare and difficult to diagnose and treat. The morbidity and mortality of intracranial complications of sinusitis have decreased significantly since the advent of antibiotics, but diseases such as subdural empyemas and intracranial abscesses still occur, and they require prompt diagnosis, treatment, and often surgical drainage to prevent death or long-term neurologic sequelae. We present a case of an immunocompetent adolescent male with a subdural empyema who presented with seizures,confusion, and focal arm weakness after a bout of sinusitis.

  12. Subdural Empyema Presenting with Seizure, Confusion, and Focal Weakness

    Science.gov (United States)

    Bruner, David I.; Littlejohn, Lanny; Pritchard, Amy

    2012-01-01

    While sinusitis is a common ailment, intracranial suppurative complications of sinusitis are rare and difficult to diagnose and treat. The morbidity and mortality of intracranial complications of sinusitis have decreased significantly since the advent of antibiotics, but diseases such as subdural empyemas and intracranial abscesses still occur, and they require prompt diagnosis, treatment, and often surgical drainage to prevent death or long-term neurologic sequelae. We present a case of an immunocompetent adolescent male with a subdural empyema who presented with seizures, confusion, and focal arm weakness after a bout of sinusitis. PMID:23358438

  13. Electrodiagnosis in the management of focal neuropathies: the "WOG" syndrome.

    Science.gov (United States)

    Brown, W F; Dellon, A L; Campbell, W W

    1994-11-01

    The role of electrodiagnosis in managing patients with focal neuropathies is discussed from the differing perspectives of a peripheral nerve surgeon and a practitioner of electrodiagnostic medicine. Both clinical evaluation and electrodiagnosis are useful methodologies, each having limitations. Dr. Dellon labels the overreliance on electrodiagnosis and the "WOG" (Word of God) syndrome, and describes its signs, symptoms, and treatment. Dr. Brown contends Dr. Dellon's crusade is misdirected. The exchange is an eloquent polemic on the virtues and foibles of these different approaches to evaluating peripheral nerve function and the imperative to practice them in a complementary rather than a contentious manner.

  14. Past Tense in Children with Focal Brain Lesions

    OpenAIRE

    Konstantinopoulou, P.; Stavrakaki, S.; Manouilidou, C.; Zafeiriou, D.

    2013-01-01

    In this study, 22 children with early left hemisphere (LHD) or right hemisphere (RHD) focal brain lesions (FL, n ¼ 14 LHD,\\ud n ¼ 8 RHD) were administered an English past tense elicitation test (M ¼ 6:5 years). Proportion correct and frequency of overregularization\\ud and zero-marking errors were compared to age-matched samples of children with specific language impairment (SLI,\\ud n ¼ 27) and with typical language development (TD, n ¼ 27). Similar rates of correct production and error patter...

  15. The immunological synapse: a focal point for endocytosis and exocytosis.

    Science.gov (United States)

    Griffiths, Gillian M; Tsun, Andy; Stinchcombe, Jane C

    2010-05-03

    There are many different cells in the immune system. To mount an effective immune response, they need to communicate with each other. One way in which this is done is by the formation of immunological synapses between cells. Recent developments show that the immune synapse serves as a focal point for exocytosis and endocytosis, directed by centrosomal docking at the plasma membrane. In this respect, formation of the immunological synapse bears striking similarities to cilia formation and cytokinesis. These intriguing observations suggest that the centrosome may play a conserved role in designating a specialized area of membrane for localized endocytosis and exocytosis.

  16. Cosmetic Effect of Botulinum Toxin In Focal Hyperhydrosis

    Directory of Open Access Journals (Sweden)

    Jain S

    2005-01-01

    Full Text Available Hyperhydrosis of axillae, palm and sole is not a very uncommon problem. It leads to great embarrassment and considerable emotional stress to the individuals. Botulinum toxins prevent the release of acetylcholine at nerve terminals, therefore, reduces sweat secretion. Six patients of axillary and 4 patients of palmer and planter hyperhydrosis were treated with botulinum toxin. All patients experienced relatively satisfactory reduction of hyperhydrosis for period ranging between 4-7 months. No adverse effects were observed. Botulinum toxin therefore can be considered as an effective treatment in focal hyperhydrosis.

  17. Radiofrequency Ablation Effectively Treated Focal Recurrence of Mesothelioma.

    Science.gov (United States)

    Nakamura, Akifumi; Takuwa, Teruhisa; Hashimoto, Masaki; Kondo, Nobuyuki; Takaki, Haruyuki; Fujiwara, Masayuki; Yamakado, Koichiro; Hasegawa, Seiki

    2018-02-01

    A 55-year-old man with malignant pleural mesothelioma underwent multimodality treatment comprising induction chemotherapy followed by extrapleural pneumonectomy and radiation therapy. After 2.5 years, focal recurrence occurred, with computed tomography revealing a tumor in the left cardiophrenic angle. Surgery was considered a problem for the patient because of the previous extrapleural pneumonectomy and difficult tumor location. Radiofrequency ablation was thus performed; the course was uneventful, and there was no recurrence. Radiofrequency ablation should be considered an option to treat recurrence of malignant pleural mesothelioma. Copyright © 2018 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  18. Malformaciones congénitas en hijos de madres epilépticas con y sin tratamiento con anticonvulsivantes Congenital malformations in the offspring of epileptic mothers with and without anticonvulsant treatment

    Directory of Open Access Journals (Sweden)

    Jazmín Arteaga-Vázquez

    2012-12-01

    Full Text Available OBJETIVO: Determinar la frecuencia y tipo de malformaciones congénitas (MC en hijos de madres epilépticas (HME tratadas y no tratadas con anticonvulsivantes, la posible correlación anticonvulsivante/MC y la asociación con otras alteraciones del desarrollo. MATERIAL Y MÉTODOS: Estudio multicéntrico de casos y controles en 166 recién nacidos vivos HME identificados en 21 501 recién nacidos con MC y respectivos controles del Registro y Vigilancia Epidemiológica de Malformaciones Congénitas (RYVEMCE. RESULTADOS: La frecuencia de MC en HME tratadas fue mayor, (48.3% que en HME no tratadas (28.3%; (RM= 2.37 IC95% 1.08-5.40, p=0.03. Las MC más frecuentes fueron espina bífida, anomalías en reducción de miembros, labio/paladar hendido, microcefalia, anotia/microtia, hipospadias, paladar hendido, polidactilia, anoftalmia/microftalmia y onfalocele. No hubo diferencias entre uso de mono o politerapia. La difenilhidantoína, carbamazepina y ácido valproico fueron los anticonvulsivantes más utilizados. CONCLUSIONES: Los resultados confirman la teratogenicidad propia de la epilepsia y el efecto sinérgico de ciertos anticonvulsivantes, lo que evidencia la necesidad de un apropiado control periconcepcional de esta enfermedad y su tratamiento.OBJECTIVE: To determine the prevalence at birth and type of congenital malformations (CM in newborns of epileptic mothers (NEM treated and not treated with anticonvulsants, the correlation anticonvulsant/CM and other developmental disorders. MATERIALS AND METHODS: Multicenter case-control study, in 166 live births NEM diagnosed in 21 501 newborns with CM and respective controls from the Registro y Vigilancia Epidemiológica de Malformaciones Congénitas (RYVEMCE. RESULTS: The frequency of CM in NEM treated with anticonvulsants was higher (48.3% than in NEM of untreated mothers (28.3%, (OR= 2.37 IC95% 1.08-5.40, p=0.03. CMs most frequently found were: spina bifida, limb reduction defects, cleft lip palate

  19. Amortización de préstamos con cuotas uniformes vencidas a interés simple

    OpenAIRE

    Aliaga V, Carlos; Aliaga C, Carlos

    2017-01-01

    Resumen En el modelo de amortización de préstamos a interés simple con cuotas uniformes vencidas y periodos de cuota uniformes, pueden identificarse dos tipos: Tipo 1: Todas las cuotas del préstamo amortizan principal. Tipo 2: Préstamos con interés simple cuando el principal queda cancelado antes de la última cuota. Utiliza una ecuación de equivalencia financiera a interés simple, que toma como fecha focal el final del horizonte del préstamo y calcula en ese momento el importe de la cuota u...

  20. Modelos parentales y su relación con la violencia en las parejas del mismo sexo

    OpenAIRE

    Ronzón-Tirado, Rosa Carolina; Rey Yedra, Luis; González-Flores, María del Pilar

    2017-01-01

    Este artículo forma parte de una investigación más amplia cuyo objetivo fue describir los elementos relacionados con la violencia en parejas gays y lésbicas. Abordamos los resultados sobre la relación de los modelos parentales con la violencia ejercida al interior de estas y otras relaciones interpersonales. Seguimos un método descriptivo cualitativo y utilizamos grupos focales para recopilar la información, en donde participaron ocho hombres gays, seis mujeres lesbianas y una mujer bisexual,...

  1. Tratamiento con implantes Leader-Nano en paciente con oligodoncia

    Directory of Open Access Journals (Sweden)

    Salvador Javier Santos Medina

    2015-03-01

    Full Text Available Los implantes dentales de titanio han revolucionado el mundo de la rehabilitación desde su surgimiento. De manera particular, el empleo de implantes de carga inmediata acorta el tiempo quirúrgico y protésico, con el consiguiente bienestar estético. Se presenta el caso de una paciente femenina de 32 años de edad, con antecedentes de oligodoncia de ambos incisivos laterales superiores y portadora de prótesis parcial acrílica. Fue atendida por el equipo multidisciplinario de implantes en la Clínica Estomatológica Docente “3 de Octubre” y se le realizó tratamiento de rehabilitación integral con implantes Leader-Nano y prótesis fija con corona acrílica sobre dichos implantes. La implantología fue satisfactoria en la paciente; la mejoría estética y funcional, así como la satisfacción de la paciente, fueron los principales logros obtenidos

  2. con dietas suplementadas con Cromo-L-metionina

    Directory of Open Access Journals (Sweden)

    Ram\\u00F3n Garc\\u00EDa-Castillo

    2006-01-01

    Full Text Available Un total de 48 cerdos (Sus scrofa domesticus; 24 machos castrados y 24 hembras cruzados (Yorkshire, Hampshire, Duroc y Landrace de 3,5 a 4,0 meses de edad y 60,0 ± 5,0 kg PV en finalización. Se alimentaron con dietas isoproteícas (14,5 % PC e isoenergéticas (3.400 kcal EM/kg de MS, adicionadas con Cr-L-metionina (MiCroPlex® (0, 200, 400 y 600 ppb. El experimento tuvo una duración de 45 días y se realizó de agosto a noviembre del 2002 en las instalaciones de la Universidad Autónoma Agraria Antonio Narro, localizada en Saltillo, Coahuila, México. Al tener los animales aproximadamente 95 kg PV, se tomó muestra de 15 ml de sangre por cada animal para determinar la concentración de glucosa, ácido úrico, creatinina, urea, proteinas totales y colesterol. Se aplicó un diseño completamente al azar con arreglo factorial 2 x 4; dos para el factor sexo y cuatro para nivel de cromo. Los metabolitos en suero no fueron afectados (P>0,05 por el factor sexo. La glucosa en suero disminuyó (P<0,05 y el colesterol incrementó (P<0,05 con cromo en la dieta. Se concluye que el Cr incrementa el metabolismo de glucosa y disminuye el de colesterol, con lo cual puede haber energía disponible para síntesis de proteína la cual es necesaria para el crecimiento de los animales

  3. Focal colors across languages are representative members of color categories.

    Science.gov (United States)

    Abbott, Joshua T; Griffiths, Thomas L; Regier, Terry

    2016-10-04

    Focal colors, or best examples of color terms, have traditionally been viewed as either the underlying source of cross-language color-naming universals or derived from category boundaries that vary widely across languages. Existing data partially support and partially challenge each of these views. Here, we advance a position that synthesizes aspects of these two traditionally opposed positions and accounts for existing data. We do so by linking this debate to more general principles. We show that best examples of named color categories across 112 languages are well-predicted from category extensions by a statistical model of how representative a sample is of a distribution, independently shown to account for patterns of human inference. This model accounts for both universal tendencies and variation in focal colors across languages. We conclude that categorization in the contested semantic domain of color may be governed by principles that apply more broadly in cognition and that these principles clarify the interplay of universal and language-specific forces in color naming.

  4. VERIFICATION OF THE SENTINEL-4 FOCAL PLANE SUBSYSTEM

    Directory of Open Access Journals (Sweden)

    C. Williges

    2017-05-01

    Full Text Available The Sentinel-4 payload is a multi-spectral camera system which is designed to monitor atmospheric conditions over Europe. The German Aerospace Center (DLR in Berlin, Germany conducted the verification campaign of the Focal Plane Subsystem (FPS on behalf of Airbus Defense and Space GmbH, Ottobrunn, Germany. The FPS consists, inter alia, of two Focal Plane Assemblies (FPAs, one for the UV-VIS spectral range (305 nm … 500 nm, the second for NIR (750 nm … 775 nm. In this publication, we will present in detail the opto-mechanical laboratory set-up of the verification campaign of the Sentinel-4 Qualification Model (QM which will also be used for the upcoming Flight Model (FM verification. The test campaign consists mainly of radiometric tests performed with an integrating sphere as homogenous light source. The FPAs have mainly to be operated at 215 K ± 5 K, making it necessary to exploit a thermal vacuum chamber (TVC for the test accomplishment. This publication focuses on the challenge to remotely illuminate both Sentinel-4 detectors as well as a reference detector homogeneously over a distance of approximately 1 m from outside the TVC. Furthermore selected test analyses and results will be presented, showing that the Sentinel-4 FPS meets specifications.

  5. Encephalitozoon cuniculi causes focal anterior cataract and uveitis in dogs.

    Science.gov (United States)

    Nell, B; Csokai, J; Fuchs-Baumgartinger, A; Maaß, G

    2015-01-01

    Three mongrel dogs, aged 10 months (case 1), 14 months (case 2) and 7.5 years (case 3), were presented because of ophthalmologic disorders of 4 months, 6 months and 7 years duration, respectively. All three dogs were offspring of stray dogs from Hungary and Serbia and had positive serum antibody titres against Encephalitozoon (E.) cuniculi. The two young dogs showed unilateral, the older dog bilateral chronic anterior uveitis with posterior synechia and focal anterior cortical cataract. The fundi that could be evaluated developed focal tapetal hyporeflective lesions in the course of the disease. Dogs 1 and 2 underwent removal of the lens via phacoemulsification. PCR of the lens material was positive for E. cuniculi strains IV and II, respectively. In dog 2 findings suggestive of microsporidia were detected underneath the anterior lens capsule by immunohistochemical staining. In all cases medical treatment consisted of systemic fenbendazole, prednisolone, and topical anti-inflammatory drugs, and additional brinzolamid/timolol for dog 3. For the time being all cases (follow up 23 months, 6 months and 3 months, respectively) are still on topical anti-inflammatory therapy. It is concluded that E. cuniculi infections can cause cataract and chorioretinal lesions in dogs.

  6. Transcranial Magnetic Stimulation-coil design with improved focality

    Science.gov (United States)

    Rastogi, P.; Lee, E. G.; Hadimani, R. L.; Jiles, D. C.

    2017-05-01

    Transcranial Magnetic Stimulation (TMS) is a technique for neuromodulation that can be used as a non-invasive therapy for various neurological disorders. In TMS, a time varying magnetic field generated from an electromagnetic coil placed on the scalp is used to induce an electric field inside the brain. TMS coil geometry plays an important role in determining the focality and depth of penetration of the induced electric field responsible for stimulation. Clinicians and basic scientists are interested in stimulating a localized area of the brain, while minimizing the stimulation of surrounding neural networks. In this paper, a novel coil has been proposed, namely Quadruple Butterfly Coil (QBC) with an improved focality over the commercial Figure-8 coil. Finite element simulations were conducted with both the QBC and the conventional Figure-8 coil. The two coil's stimulation profiles were assessed with 50 anatomically realistic MRI derived head models. The coils were positioned on the vertex and the scalp over the dorsolateral prefrontal cortex to stimulate the brain. Computer modeling of the coils has been done to determine the parameters of interest-volume of stimulation, maximum electric field, location of maximum electric field and area of stimulation across all 50 head models for both coils.

  7. High operating temperature interband cascade focal plane arrays

    Energy Technology Data Exchange (ETDEWEB)

    Tian, Z.-B.; Godoy, S. E.; Kim, H. S.; Schuler-Sandy, T.; Montoya, J. A.; Krishna, S. [Center for High Technology Materials, Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, New Mexico 87106 (United States)

    2014-08-04

    In this paper, we report the initial demonstration of mid-infrared interband cascade (IC) photodetector focal plane arrays with multiple-stage/junction design. The merits of IC photodetectors include low noise and efficient photocarrier extraction, even for zero-bias operation. By adopting enhanced electron barrier design and a total absorber thickness of 0.7 μm, the 5-stage IC detectors show very low dark current (1.10 × 10{sup −7} A/cm{sup 2} at −5 mV and 150 K). Even with un-optimized fabrication and standard commercial (mis-matched) read-out circuit technology, infrared images are obtained by the 320 × 256 IC focal plane array up to 180 K with f/2.3 optics. The minimum noise equivalent temperature difference of 28 mK is obtained at 120 K. These initial results indicate great potential of IC photodetectors, particularly for high operating temperature applications.

  8. High operating temperature interband cascade focal plane arrays

    International Nuclear Information System (INIS)

    Tian, Z.-B.; Godoy, S. E.; Kim, H. S.; Schuler-Sandy, T.; Montoya, J. A.; Krishna, S.

    2014-01-01

    In this paper, we report the initial demonstration of mid-infrared interband cascade (IC) photodetector focal plane arrays with multiple-stage/junction design. The merits of IC photodetectors include low noise and efficient photocarrier extraction, even for zero-bias operation. By adopting enhanced electron barrier design and a total absorber thickness of 0.7 μm, the 5-stage IC detectors show very low dark current (1.10 × 10 −7 A/cm 2 at −5 mV and 150 K). Even with un-optimized fabrication and standard commercial (mis-matched) read-out circuit technology, infrared images are obtained by the 320 × 256 IC focal plane array up to 180 K with f/2.3 optics. The minimum noise equivalent temperature difference of 28 mK is obtained at 120 K. These initial results indicate great potential of IC photodetectors, particularly for high operating temperature applications

  9. Multivariate analysis of magnetic resonance imaging of focal hepatic lesions

    International Nuclear Information System (INIS)

    Fujishima, Mamoru; Suemitsu, Ichizou; Sei, Tetsurou; Takeda, Yoshihiro; Hiraki, Yoshio

    1993-01-01

    A total of 124 lesions from 1 to 6 cm in diameter, including 31 cavernous hemangiomas, 32 metastases and 61 hepatocellular carcinomas (HCC) were analyzed to study the usefulness of magnetic resonance imaging (MRI) at 0.5 Tesla to differentiate focal hepatic lesions on the basis of qualitative criteria. Each focal hepatic lesion was assessed for shape, internal architecture and signal intensity relative to normal liver parenchyma. While all cavernous hemangiomas and metastases except one lesion could be detected, detection rate of HCC was significantly inferior to that of the other two diseases. A tumor capsule and a hyperintense focus on T 1 -weighted images were demonstrated in only HCC lesions in strong contrast with the other two diseases; however, metastases with slow-growing characteristics or subacute hematoma may appear as similar images. Cavernous hemangiomas appeared markedly hyperintense on T 2 -weighted images in 23 of 31 lesions, but one metastasis and one HCC had similar images. A multivariate analysis of several MRI resulted in the following mean discriminant scores: cavernous hemangioma, -1.2652; metastasis, 0.1830; and HCC, 0.7138. It appeared to be possible to differentiate the three diseases with 84.4 percent accuracy. (author)

  10. Verification of the Sentinel-4 focal plane subsystem

    Science.gov (United States)

    Williges, Christian; Uhlig, Mathias; Hilbert, Stefan; Rossmann, Hannes; Buchwinkler, Kevin; Babben, Steffen; Sebastian, Ilse; Hohn, Rüdiger; Reulke, Ralf

    2017-09-01

    The Sentinel-4 payload is a multi-spectral camera system, designed to monitor atmospheric conditions over Europe from a geostationary orbit. The German Aerospace Center, DLR Berlin, conducted the verification campaign of the Focal Plane Subsystem (FPS) during the second half of 2016. The FPS consists, of two Focal Plane Assemblies (FPAs), two Front End Electronics (FEEs), one Front End Support Electronic (FSE) and one Instrument Control Unit (ICU). The FPAs are designed for two spectral ranges: UV-VIS (305 nm - 500 nm) and NIR (750 nm - 775 nm). In this publication, we will present in detail the set-up of the verification campaign of the Sentinel-4 Qualification Model (QM). This set up will also be used for the upcoming Flight Model (FM) verification, planned for early 2018. The FPAs have to be operated at 215 K +/- 5 K, making it necessary to exploit a thermal vacuum chamber (TVC) for the test accomplishment. The test campaign consists mainly of radiometric tests. This publication focuses on the challenge to remotely illuminate both Sentinel-4 detectors as well as a reference detector homogeneously over a distance of approximately 1 m from outside the TVC. Selected test analyses and results will be presented.

  11. Differentiation of focal liver lesions by contrast-enhanced MRI

    International Nuclear Information System (INIS)

    Heintz, P.; Ehrenheim, C.

    1989-01-01

    47 patients with liver tumours (haemangioma, focal nodular hyperplasia, hepatocellular carcinoma) underwent MRI of the liver before and after i.v. injection of 0.2 ml./kg. gadolinium-DTPA in addition to other imaging methods. The demarcation of focal nodular hyperplasia is not influenced by use of the contrast agent as it almost behaves like surrounding normal liver tissue, thus only indirectly facilitating its identification. With regard to liver haemangiomas that show the most intensive uptake of gadolinium-DTPA, the contrast enhanced image does not reach to contrast and sensitivity of a native T 2 -weighted SE image, especially in cases of small haemangiomas. The contrast agent is helpful, however, in the recognition of large cavernous haemangiomas that are partially fibrotic or thrombotic. Emphasis is given to the contrast agent in hepatomas: gadolinium-DTPA presents a pattern of uptake and distribution frequently found in hepatocellular carcinoma providing additional information on the delineation of internal tumour details. (orig.) [de

  12. Zinc translocation accelerates infarction after mild transient focal ischemia.

    Science.gov (United States)

    Lee, J-M; Zipfel, G J; Park, K H; He, Y Y; Hsu, C Y; Choi, D W

    2002-01-01

    Excess release of chelatable zinc (Zn(2+)) from central synaptic vesicles may contribute to the pathogenesis of selective neuronal cell death following transient forebrain ischemia, but a role in neurodegeneration after focal ischemia has not been defined. Adult male Long-Evans rats subjected to middle cerebral artery occlusion (MCAO) for 30 min followed by reperfusion developed delayed cerebral infarction reaching completion 3 days after the insult. One day after the insult, many degenerating cerebral neurons exhibited increased intracellular Zn(2+), and some labeled with the antibody against activated caspase-3. I.c.v. administration of the Zn(2+) chelator, EDTA saturated with equimolar Ca(2+) (CaEDTA), 15 min prior to ischemia attenuated subsequent Zn(2+) translocation into cortical neurons, and reduced infarct volume measured 3 days after ischemia. Although the protective effect of CaEDTA at this endpoint was substantial (about 70% infarct reduction), it was lost when insult severity was increased (from 30 to 60 min MCAO), or when infarct volume was measured at a much later time point (14 days instead of 3 days after ischemia). These data suggest that toxic Zn(2+) translocation, from presynaptic terminals to post-synaptic cell bodies, may accelerate the development of cerebral infarction following mild transient focal ischemia.

  13. Evaluación del prelenguaje tras aplicación de programa de estimulación en niños con factores de riesgo perinatales

    Directory of Open Access Journals (Sweden)

    Leydelys Castillo Valdés

    2014-04-01

    Full Text Available Introducción: en la formación del prelenguaje es fundamental la estimulación sensorial que recibe el niño. Objetivo: implementar un programa de estimulación para la prevención y el tratamiento oportuno de los trastornos del lenguaje en niños con factores de riesgo perinatales, de modo que permita un desarrollo adecuado de los elementos básicos de la comunicación oral partiendo de los resultados de la evaluación en cada sub-etapa del prelenguaje. Material y método: se realizó un estudio observacional, descriptivo, longitudinal, prospectivo en la consulta de Neurodesarrollo del Hospital General Docente "Abel Santamaría Cuadrado" de Pinar del Río, en el período 2010-2011; tomando los datos de la Historia Clínica Logofoniátrica procesados mediante el sistema estadístico InfStat 1.0. El universo estuvo integrado por 183 niños y la muestra por 142 niños que cumplieron los criterios de inclusión. Resultados: en la muestra se presentaron 68 factores de riesgo prenatales, 234 perinatales y 150 neonatales. En la evaluación al finalizar el prelenguaje el 94% de los niños tuvo un desarrollo del lenguaje acorde a su edad, el 4% un desarrollo normal retardado y un 2% se retrasó. Estos presentaron como causa secundaria Curso atípico del desarrollo, Hipoacusia neurosensorial bilateral profunda y Epilepsia. Predominó la buena eficacia al tratamiento. Conclusiones: de este estudio se concluye que con la puesta en práctica del programa de estimulación se logró que los niños alcanzaran un desarrollo del lenguaje en correspondencia a su edad, mejorando su calidad de vida.

  14. Recubrimiento de acero con polidopamina

    OpenAIRE

    Carrasco Rodríguez, Javier

    2013-01-01

    Se ha obtenido recubrimientos de polidopamina en acero mecánicamente resistentes y con tiempos de obtención relativamente pequeños a través de la polimerización de la dopamina bajo diferentes condiciones.

  15. Unilateral proximal focal femoral deficiency, fibular aplasia, tibial ...

    African Journals Online (AJOL)

    Rabah M. Shawky

    2014-04-30

    Apr 30, 2014 ... Peer review under responsibility of Ain Shams University. ... The fibular field of the limb bud controls the development of ... The mental and physical developments are ... deficiency, short tibia and absent fibula of the right lower limb compared ... brother has tetrameric transverse defect and a cyanotic con-.

  16. Hiperceratose focal acral associada à hipocromia de dermatóglifos Focal acral hyperkeratosis with hypochromic dermatoglyphics

    Directory of Open Access Journals (Sweden)

    Roberto Rheingantz da Cunha Filho

    2008-10-01

    Full Text Available Hiperceratose focal acral é dermatose rara caracterizada por pápulas ceratóticas acrais que afetam preferencialmente as superfícies marginais das mãos e dos pés, pertencendo ao grupo das hiperceratoses marginais. Apresentamos variante inédita de mulher de 45 anos de idade, branca, dona-de-casa, sem história familiar, com lesões ceratóticas papulosas localizadas nos pés e hipocromia de dermatóglifos na região afetada. Histologicamente apresentou hiperortoceratose, desnível da epiderme (degrau, acantose e hipergranulose. Os tratamentos com ceratolíticos tópicos foram ineficientes, de forma semelhante aos casos descritos na literatura atual.Focal acral hyperkeratosis is a rare condition, characterized by acral keratotic papules that preferably affect hand and foot surfaces, and are included in the spectrum of marginal papular keratodermas. We report an unpublished variant of this condition, the case of a 45-year-old Caucasian woman with acral keratotic papular lesions and hypochromic dermatoglyphics in the feet. Histological examination revealed orthohyperkeratosis, depression of the epidermis, acanthosis and hypergranulosis. Topical treatments with keratolytics were ineffective, similarly to previously described cases.

  17. 99mTc-HM-PAO SPECT of epileptic patients showing focal paroxysm on electroencephalography

    International Nuclear Information System (INIS)

    Takaishi, Yasuko; Hashimoto, Kiyoshi; Fujino, Osamu; Kamayachi, Satoshi; Fujita, Takehisa; Enokido, Hisashi; Komatsuzaki, Hideki; Kawakami, Yasuhiko; Hirayama, Tsunenori

    1995-01-01

    The usefulness of 99m Tc-HM-PAO SPECT in diagnosing epilepsy was studied. The subjects were 33 epileptic patients, ranging in age from 5 years and 5 months to 28 years and 3 months, who showed focal paroxysm on electroencephalograms. Lowered accumulation site was found on SPECT in 19 patients. Four patients with abnormal findings on X-ray CT or MRI showed lowered accumulation and focal paroxysm at the same site. Of 29 patients with normal X-ray CT or MRI findings, 15 (52%) showed lowered accumulation. Five patients showed a focal paroxysm at the site of lowered accumulation. In 8 patients the focal paroxysm site was partly coincided with the accumulation site. In some patients the focal site predicted by the findings of clinical symptoms and the lowered accumulation site coincided. SPECT is therefore a useful method in diagnosing a focal site in epilepsy and considered to reflect the severity of disease. (Y.S.)

  18. Análises visual e volumétrica por ressonância magnética das formações hipocampais em um grupo de pacientes com diagnóstico clínico de epilepsia do lobo temporal

    Directory of Open Access Journals (Sweden)

    ROGACHESKI ÊNIO

    1998-01-01

    Full Text Available Visando comparar a sensibilidade da avaliação volumétrica com a análise visual na avaliação por ressonância magnética (RM das formações hipocampais de pacientes com epilepsia do lobo temporal refratária e candidatos à lobectomia temporal, estudamos 153 casos com diagnóstico clínico de epilepsia do lobo temporal, utilizando um equipamento de 0,5 Tesla, com técnica de inversion-recovery ponderada em T1, com cortes de 5 mm no plano coronal. Houve boa concordância entre a análise visual prospectiva e outra retrospectiva, realizada por dois observadores independentes (C=0,748 e 0,720. Houve também concordância entre a análise retrospectiva dos dois observadores (C=0,733. Houve ainda concordância genuína (C=0,788 entre os resultados das análises quantitativa e qualitativa realizadas prospectivamente. A análise quantitativa demonstrou uma tendência não-significativa a lateralizar mais casos de atrofia hipocampal presumida clinicamente. Nossos resultados confirmam a confiabilidade da análise visual qualitativa e indicam a utilidade da volumetria hipocampal como uma medida suplementar, objetiva e quantitativa, de esclerose hipocampal.

  19. Funcionamento intelectual em pacientes pediátricos com epilepsia: comparação de crianças controladas com medicação, não controladas com medicação e controladas com cirurgia Intellectual functioning in pediatric patients with epilepsy: a comparison of medically controlled, medically uncontrolled and surgically controlled children

    Directory of Open Access Journals (Sweden)

    Cecília Souza-Oliveira

    2010-10-01

    Full Text Available OBJETIVO: Comparar o quociente intelectual (QI em três grupos de crianças com epilepsia: 1 controlados com medicação, 2 não controlados com medicação e 3 controlados com cirurgia. MÉTODOS: Noventa e oito pacientes pediátricos, com idades entre 6 e 12 anos, foram selecionados de dezembro de 2007 a julho de 2008. A Escala de Inteligência Wechsler para Crianças - terceira edição (WISC-III foi utilizada para a avaliação neuropsicológica dos pacientes. Os resultados foram relacionados com a síndrome epiléptica, a etiologia da epilepsia, o tratamento medicamentoso, a idade do paciente no início da epilepsia e a duração da epilepsia. RESULTADOS: Os escores da WISC foram significativamente melhores no grupo controlado com medicação quando comparados aos do grupo não controlado com medicação. O grupo controlado com medicação obteve um desempenho significativamente melhor na maioria dos subtestes da WISC quando comparado ao grupo não controlado com medicação: vocabulário, aritmética, compreensão, memória de dígitos, completar figuras, arranjo de figuras e cubos. Um número significativamente maior de pacientes com epilepsia idiopática e uso de monoterapia foi observado no grupo controlado com medicação quando comparado ao grupo não controlado. O grupo controlado com cirurgia não apresentou diferença significativa no desempenho do QI quando comparado ao grupo controlado com medicação. CONCLUSÕES: As crianças com um bom controle de crises tiveram um melhor desempenho no QI geral, verbal e de execução quando comparadas às crianças com epilepsia refratária. Esses resultados podem ser influenciados por fatores clínicos como o uso de monoterapia, o tipo de droga antiepiléptica utilizada, a síndrome epiléptica e a etiologia da epilepsia. A cirurgia de epilepsia pode causar um impacto positivo no desempenho cognitivo das crianças que ficaram livres de crises após o procedimento cirúrgico.OBJECTIVE: To

  20. Santiago, una ciudad con temor

    Directory of Open Access Journals (Sweden)

    Enrique Oviedo S.

    1999-04-01

    Full Text Available El objetivo general de este artículo es evaluar los efectos de la inseguridad ciudadana en el uso del espacio público. Dicha evaluación exige analizar dos relaciones que se establecen en el ámbito de la violencia: la relación entre victimización y percepción de inseguridad; y la que se establece entre actitudes sociales y resolución pacífica de conflictos nacionales. Para ello, se analizaron las variables victimización, percepción de inseguridad, uso del espacio físico, actitudes hacia el sistema institucional político y social y hacia la resolución de conflictos nacionales, y las posibles relaciones entre ellas. Los datos para realizar el estudio se obtuvieron por medio de una encuesta que se llevó a cabo con 1 200 personas de 18 y 70 años de edad residentes en la ciudad de Santiago. Los resultados indican que Santiago es una ciudad de habitantes con temor y que el aumento de la percepción de inseguridad de sus habitantes contrasta con el hecho de que las tasas de victimización se hayan mantenido, más o menos, constantes en los años que precedieron a la encuesta. El temor se relaciona con el abandono del espacio público físico y sociopolítico, así como con el refugio en los espacios y la vida privados. La actitud de resolver los conflictos por medios no pacíficos es frecuente y se asocia en mayor medida con la inseguridad, la actitud negativa hacia la democracia y la falta de expectativas sobre el futuro del país. Los resultados de este estudio respaldan la idea de que para superar el temor la gente tiende a adaptarse a la realidad adoptando una postura conformista, homogeneizando las creencias y los comportamientos, y sobreestimando la fuerza como medio para resolver las diferencias.