WorldWideScience

Sample records for con biopsia transrectal

  1. Biopsia aspirativa con aguja fina del tiroides

    Directory of Open Access Journals (Sweden)

    Regino Piñeiro Lamas

    1996-08-01

    Full Text Available Se estudiaron 33 pacientes con afecciones tiroideas, procedentes de la consulta de Endocrinología Infantil del Hospital Pediátrico Docente "Juan Manuel Márquez", durante los años 1992 y 1993; 19 presentaron bocio difuso generalizado de tamaño II o III, 5 tenían bocio nodular, 4 bocio multinodular, 3 nódulos solitarios y 2 quiste de la glándula. A todos se les realizó biopsia aspirativa con aguja fina (BAF del tiroides, y fueron las conclusiones las siguientes: La BAF fue útil para el diagnóstico de la tiroiditis linfocítica crónica, pues se detectó en 16 pacientes (52 % de la serie; también fue útil en los 2 pacientes con quiste de la glándula. El proceder fue útil para la detección de lesiones malignas del tiroides, pues de 7 pacientes con nódulo único o bocio nodular, se detectó en 2 carcinoma papilar (estadio IV, en 1 se informó "sospechoso"(estadio III que corresponde a un nódulo coloide, el resto fue informado como benigno, para corresponder esto con las biopsias posquirúrgicas, para una sensibilidad del 100 % y especificidad del 80 %.33 patients with thyroid affections, coming from the Children's Endocrinology Department of the "Juan Manuel Márquez" Pediatric Teaching Hospital, were studied during 1992-1993. 19 presented size II or III generalized diffuse goiter; 5, nodular goiter; 4, multinodular goiter; 3, lone nodules; and 2, thyroid gland cyst. All of them underwent fine-needle aspiration biopsy (FAB of the thyroid. The conclusions reached were the following: FAB was useful for the diagnosis of chronic lymphocytic thyroiditis, since it was detected in 16 patients (52 % of the series; it was also useful in 2 patients with cyst of the thyroid gland. The procedure was of use for detecting malignant thyroid lesions as of 7 patients with lone nodule or nodular goiter, 2 papillary carcinomas were detected (stage IV, one was considered as "suspicious" (stage III, corresponding to a colloid nodule, and the rest was

  2. Biopsia de la próstata, aspiración con aguja fina

    OpenAIRE

    Gómez Lloreda, Eugenio; Chavarro Porras, Jorge; Martínez Garzón, Miguel

    2012-01-01

    Se presentan los resultados preliminares de biopsia por punción con aguja tina de la próstata en cuanto a su tolerancia por parte de los pacientes, su fácil manejo por parte del urólogo y su interpretación desde el punto de vista histopatológico. Los resultados comparativos entre la biopsia por punción con aguja fina y la biopsia con Tru-Cut son similares en cuanto a la certeza en el diagnóstico del cáncer de próstata, pero las complicaciones médicas son mucho menores en la biopsia por punció...

  3. BIOPSIA QUIRURGICA CON MARCACION PREOPERATORIA EN LESIONES NO PALPABLES DE LA MAMA: EXPERIENCIA DE 10 AÑOS

    OpenAIRE

    Pardo G,Mario; Sepúlveda P,Sergio; Cuevas G,Claudia; Díaz G,Carolina

    2003-01-01

    El uso sistemático de la mamografía y ultrasonido ha incrementado el diagnóstico de lesiones mamarias no palpables y con ello, la indicación de biopsia. Material y Método: Presentamos nuestra experiencia en 315 biopsias excisionales de lesiones mamarias ocultas con localización preoperatoria. Utilizamos la mamografía en el 83,8% y el ultrasonido en el 10,5% de los casos para posicionar una guía metálica; en el 5,7% se realizó marcación sobre la piel, guiada por ultrasonido. Resultados: Obtuvi...

  4. Repeat biopsy in patients with initial diagnosis of PIN; La biopsia ripetuta nei pazienti con diagnosi iniziale di PIN

    Energy Technology Data Exchange (ETDEWEB)

    De Matteis, Massimo [Azienda Ospedaliera Policlinico S. Orsola-Malpighi, Bologna (Italy). UO Radiologia Albertoni; Poggi, Cristina; De Martino, Antonietta; Pavlica, Pietro [Azienda Ospedaliera Policlinico S. Orsola-Malpighi, Bologna (Italy). UO Radiologia Palagi, Dipartimento area radiologica; Corti, Barbara [Azienda Ospedaliera Policlinico S. Orsola-Malpighi, Bologna (Italy). UO Anatomia ed istologia patologica, Dipartimento oncologico ed ematologico; Barozzi, Libero [Azienda Ospedaliera Policlinico S. Orsola-Malpighi, Bologna (Italy). UO Radiologia d' urgenza, Dipartimento emergenze ed accettazione

    2005-09-15

    indirizzare i pazienti alla biopsia ripetuta. Materiale e metodi. Abbiamo valutato i risultati di 72 biopsie ripetute in pazienti con una diagnosi di PIN ad una prima agobiopsia prostatica ecoguidata. A tutti e stato effettuato un numero minimo di 6 prelievi. Tutti avevano un PSA>4 ng/ml. Risultati. Sono stati rilevati alla biopsia ripetuta 15 adenocarcinomi su 50 pazienti (30%) con diagnosi iniziale di PIN a basso grado e 10 carcinomi su 22 (45,4%) con PIN ad alto grado. Sono stati diagnosticati 7 carcinomi in 18 pazienti (39%) nei quali il PSA era diminuito durante l'intervallo di osservazione, in 16 su 46 (35%) nei quali il PSA in aumento e 2 su 8 casi (25%) con PSA stabile. Conclusioni. I risultati sembrano confermare che il PIN puo essere considerato un precursore dell'adenocarcinoma prostatico o un'alterazione istologica frequentemente associata ad esso. I pazienti con diagnosi iniziale di PIN a basso grado e soprattutto quelli con PIN ad alto grado dovrebbero sistematicamente essere sottoposti a biopsia ripetuta a breve distanza per l'elevata frequenza di diagnosi finale di carcinoma. Non esistono ancora indicazioni condivise sull'intervallo temporale tra le due biopsie. Le variazioni del PSA che si possono riscontrare durante il periodo di osservazione non rappresentano un parametro statisticamente significativo per proporre o meno al paziente la ripetizione della biopsia prostatica.

  5. Impacto de la insuficiencia renal crónica en las complicaciones post biopsia hepática con guía ecográfica

    OpenAIRE

    Portal Guth, Jorge Alberto

    2012-01-01

    Objetivo: Evaluar el impacto de la Insuficiencia Renal Crónica en las complicaciones post biopsia hepática con guía ecográfica. Materiales y Métodos: En el Servicio de Radiología del Hospital Alberto Sabogal Sologuren, durante los años 2010 a 2012, 108 pacientes tuvieron biopsia hepática por diferentes indicaciones, de los cuales 37 tenían Insuficiencia Renal Crónica. Se consideró como criterio de inclusión fundamental solo a pacientes en estadios iniciales de hepatopatías e insuficiencia ...

  6. BIOPSIA ENDOMETRIAL AMBULATORIA: EXPERIENCIA PRELIMINAR

    OpenAIRE

    Domínguez C,Claudio; Zamora F,Jessica; Barrera P,Sandra; Tacla F,Ximena

    2006-01-01

    Objetivo: Presentar la experiencia inicial en el diagnóstico histológico con biopsia endometrial ambulatoria obtenida con pipelle de Cornier. Material y método: Se efectuó biopsia endometrial ambulatoria con pipelle de Cornier en 144 pacientes con sospecha clínica y/o ecográfica de patología endometrial difusa. Resultados: Se logró realizar el procedimiento a 131 pacientes (91%), obteniéndose diagnóstico histológico satisfactorio en 110 casos (76,4%). De las 110 muestras analizadas, se diagno...

  7. Características de las úlceras gastroduodenales en pacientes con biopsia negativa para Helicobacter pylori.

    OpenAIRE

    Montes Teves, Pedro; Salazar Ventura, Sonia; Monge Salgado, Eduardo

    2014-01-01

    Objetivo. Evaluar las características clínico-epidemiológicas de la enfermedad ulcerosa péptica no asociada a infección por Helicobacter pylori (Hp). Métodos. En este estudio de corte transversal se incluyeron 651 pacientes con diagnóstico de úlcera péptica atendidos durante el período enero 2000 - diciembre 2005. El diagnóstico de infección por Hp se realizó mediante histología. Se compararon las características clínicoepidemiológicas y endoscópicas de los pacientes c...

  8. Biopsia por cepillado con el OralCDx®: Estado de la cuestión

    Directory of Open Access Journals (Sweden)

    R. Matos Cruz

    2013-06-01

    Full Text Available La controversia en torno al OralCDx® (OralScan Laboratories Inc., Suffern, Nueva York se ha mantenido desde la publicación del primer estudio evaluando la validez y seguridad de esta prueba diagnóstica, como artículo de portada de la revista JADA en 1999. Aunque el estudio fue muy elogiado por algunos, otros han cuestionado la interpretación de la estadística y por consiguiente la aplicabilidad clínica de estos resultados. Esto dio lugar a lo que Greenberg designó la "controversia del cepillo" y a una incertidumbre, que aún hoy prevalece, en cuanto al uso de esta prueba diagnóstica. Entendemos que es importante llevar a cabo un análisis actualizado de la literatura que permita resumir la evidencia actual en torno al OralCDx®. El objetivo de este artículo es realizar una revisión bibliográfica relacionada con la precisión del sistema de Test de cepillado OralCDx® como técnica adyuvante de diagnóstico de LOMP. Se resumen datos acerca del diseño, muestras y características del grupo de estudio, intervenciones, resultados comunicados y medidas básicas de precisión diagnóstica de este método adyuvante, a partir de los estudios clínicos publicados entre los años de 1999 y 2013.

  9. Sensibilidad de la biopsia gástrica en la detección de Helicobacter pylori en pacientes en tratamiento con inhibidores de la bomba de protones.

    Directory of Open Access Journals (Sweden)

    Daisy Azaña

    2012-03-01

    Full Text Available Objetivo: Comparar la sensibilidad de la biopsia gástrica en la detección de Helicobacter pylori (Hp en pacientes que recibieron inhibidores de la bomba de protones (IBP entre 7 y 14 días previos a la endoscopía digestiva alta y los que recibieron medicación diferente a IBP o no usaron medicación. Material y métodos: Estudio tipo serie de casos comparativo. Se incluyeron pacientes con dispepsia sometidos a endoscopía digestiva alta y biopsia gástrica en el Servicio de Gastroenterología del Hospital Nacional Cayetano Heredia entre noviembre 2008 y enero 2009, que habían recibido IBP entre 7 y 14 días. Se excluyeron pacientes con cáncer gástrico, cirugía previa, que se encontraban en terapia antibiótica o con salicilato de bismuto en las 4 semanas previas. Se tomaron dos biopsias en cuerpo y dos en antro. Se utilizó el programa STATA 10 para el análisis. Resultados: Se estudiaron 80 pacientes; 38 (47,5% recibieron IBP. El 64,29% (27/42 de los que no tomaron IBP fueron Hp (+ y el 65,79% (23/38 de los que tomaron IBP (p=0,90. Conclusiones: La proporción de resultados positivos para Hp fue similar en los pacientes que tomaron IBP entre 7 y 14 días y los que no recibieron IBP.

  10. Estudo comparativo entre três técnicas de anestesia geral para biópsia de próstata dirigida por ultrassonografia transretal Estudio comparativo entre tres técnicas de anestesia general para biopsia de próstata dirigida por ultrasonido transrectal A comparative study among three techniques of general anesthesia for ultrasound-guided transrectal prostate biopsy

    Directory of Open Access Journals (Sweden)

    Ricardo Antônio Guimarães Barbosa

    2010-10-01

    ésicas en ese grupo de pacientes. MÉTODO: Fueron estudiados 45 pacientes divididos en tres grupos: 1- Propofol; 2- Propofol + Bloqueo de Plexo Prostático; 3- Propofol + Fentanil. Los pacientes fueron monitorizados con presión arterial no invasiva, electrocardioscopia continua, oximetría de pulso (SpO2 e Índice Bispectral. No recibieron medicación preanestésica. Se evaluaron los parámetros hemodinámicos en el intra y postoperatorio, índice bispectral en el intraoperatorio, el dolor por la escala numérica verbal (ENV en el postoperatorio inmediato y el uso de dipirona como tratamiento del dolor postoperatorio. RESULTADOS: No hubo diferencia significativa entre los tres grupos: en las variables antropométricas, cantidad de propofol, número de fragmentos y tiempo del examen. Los parámetros hemodinámicos y la SpO2 presentaron un comportamiento semejante en los tres grupos durante el estudio. En el grupo 1, el dolor evaluado por la ENV fue más elevado y hubo una mayor necesidad de aplicar la dipirona que en los otros grupos. CONCLUSIONES: La sedación con propofol aislado para la biopsia causa un mayor dolor e incomodidad en el postoperatorio que cuando se asocia al bloqueo del plexo prostático o al fentanil sistémico. Además de la hipnosis, se hace necesario realizar la analgesia intraoperatoria para garantizar la comodidad en el postoperatorioBACKGROUND AND OBJECTIVES: Ultrasound-guided transrectal prostate biopsy is a reference in the diagnosis of prostate neoplasias. The higher the number of samples, the greater is the pain and discomfort. The objective of this study was to compare three anesthetic techniques in this group of patients. METHODS: Forty-five patients were included in this study. Patients were divided into three groups: 1 - Propofol; 2 - Propofol + Prostatic Plexus Block; 3 - Propofol + Fentanyl. Patients were monitored with non-invasive blood pressure, continuous electrocardioscopy, pulse oximetry (SpO2, and Bispectral Index. Patients did not

  11. Baja frecuencia de positividad serológica en pacientes con biopsias histológicamente compatibles con enfermedad celiaca en Perú Low serological positivy in patients with histology compatible with celiac disease in Perú

    Directory of Open Access Journals (Sweden)

    F. Arévalo

    2010-06-01

    Full Text Available Objetivo: estudiar la frecuencia de positividad de las pruebas serológicas en pacientes con biopsias compatible con enfermedad celiaca. Material y métodos: estudio transversal. Se incluyeron pacientes con biopsia duodenal histológicamente compatible con enfermedad celiaca y determinación de anticuerpos antigliadina, antiendomisio y antitransglutaminasa IgA. Definimos como caso de enfermedad celiaca a quienes tuvieran biopsia positiva y anticuerpos antiendomisio y/o antitransglutaminasa positivos. Resultados: 31 pacientes fueron incluidos de los cuales 6 fueron antiendomisio positivo, 5 fueron antitransglutaminasa positivo y antigliadina fue positivo en 14. Por lo tanto de 31 pacientes con cambios histológicos compatibles con enfermedad celiaca sólo 10 tuvieron serología diagnóstica. Sólo uno de los pacientes tuvo positividad tanto para antitransglutaminasa como para antiendomisio. Conclusiones: a encontramos que la mayoría de biopsias de duodeno con un cuadro histológico sugerente de enfermedad celiaca no se corresponden con serología diagnóstica de esta enfermedad; b encontramos baja coincidencia en la positividad serológica entre antiendomisio y antitransglutaminasa.Objective: to study the frequency of positive serology for celiac disease (CD in patients with duodenal biopsies suggestive of this disease. Material and methods: cross sectional study. We included patients with duodenal biopsies histologically compatible with CD and antigliadin, antiendomysial and IgA antitransglutaminase antibodies. We defined a "case" of CD if there was a positive biopsy and either antiendomisial or antitransglutaminase positive antibodies. Results: thirty one patients were included in our study. Six were antiendomysial positive and 5 antitransglutaminase positive while the antigliadin was positive in 14 cases. Therefore, out of 31 patients only 10 had a serology compatible with CD and only one had positive both antibodies, antiendomysial and

  12. Abdominal masses in the pediatric age. Characterization by CT guided fine needle aspiration biopsy; Masse addominali nell'eta' pediatrica. Caratterizzazione mediante biopsia computerizzata con ago sottile guidata con Tomografia Computerizzata

    Energy Technology Data Exchange (ETDEWEB)

    Marano, I.; Soscia, E.; Salvatore, M. [Naples Univ. Federico 2. (Italy). Dipt. di Scienze Biomorfologiche e Fuzionali, Cattedra di Radiologia

    1999-04-01

    CT-guided fine needle aspiration biopsy (FNAB) is known to improve diagnosis of expansive abdominal lesions, especially relative to more invasive procedure like explorative laparotomy. FNAB in not commonly use in pediatric patients because of their poor collaboration and of associated risks. The authors investigated the feasibility of FNAB in the pediatric age. [Italian] Sono noti i vantaggi che la biopsia percutanea con ago sottile guidato con TC puo' apportare per la diagnosi delle lesioni espansive addominali, soprattutto se confrontata con procedure piu' invasive come la laparatomia esplorativa. Questo tipo di metodica e' attalmente poco utilizzato nel caso di pazienti pediatrici a causa della scarsa collaborazione e dei rischi associati. Gli autori valutano l'applicabilita' di tale procedura nell'eta' pediatrica alla luce delle propria esperienza.

  13. Biopsia por aspiración con aguja fina en el síndrome adénico cervical crónico

    Directory of Open Access Journals (Sweden)

    Nélido González Fernández

    1997-08-01

    Full Text Available Con el objetivo de determinar en nuestro medio el valor de la citología aspirativa con aguja fina, al evaluar una linfadenopatía cervical asintomática, como procedimiento diagnóstico preliminar, se realizó un estudio de 40 pacientes que acudieron a la consulta de otorrinolaringología del Hospital Clinicoquirúrgico Docente "Joaquín Albarrán", durante el año 1994, en los cuales se practicó primero biopsia aspirativa con aguja fina y posteriormente la extirpación quirúrgica de los ganglios afectados para evaluar los diagnósticos citopatológicos realizados. El 72,5 % de los pacientes tenían más de 50 años y el 62,5 % era del sexo masculino. Se diagnosticaron lesiones metastásicas en el 45 %, tumores primarios en el 20 %, adenitis aguda en 7,5 %. En la correlación se encontraron 2 falsos positivos (5 % e igual número de falsos negativos. La eficacia del método fue de 90 %, sensibilidad de 92,3 % y especialidad de 85,75 %. Los índices predictivos positivos y negativos fueron 92,3 y 85,7 %Forty patients who were attended at the Otorrhinolaryngology Service of "Joaquín Albarrán" Teaching Clinical and Surgical Hospital during 1994 were studied with the aim of determine in our environment the value of fine needle aspiration cytology when evaluating an asymptomatic cervical lymphoadenopathy. First, patients underwent a fine needle aspiration biopsy and afterwards they were submitted to a surgical removal of the affected ganglia to assess the cytopathologic diagnoses performed. 72.5 % of patients were over 50 years of age and 62.5 % were male. Metastatic lesions were diagnosed in 45 %, primary tumors in 20 %, and acute adenitis in 7.5 %. In the correlation, 2 false positive results were found (5 % and an equal number of false negative results. The effectiveness of the method was found to be of 90 %, sensitivity was 92.3 %, and specificity was of 85.75 %. Positive and negative predictive indexes were 92.3 and 85.7 %

  14. Dinámica del virus de la hepatitis C con carga viral y ALT y monitoreo del daño hepático libre de biopsias Dinámica del virus de la hepatitis C con carga viral y ALT y monitoreo del daño hepático libre de biopsias

    Directory of Open Access Journals (Sweden)

    Justino Alavez Domínguez

    2006-12-01

    Full Text Available Se compara el modelo estándar reducido de tres poblaciones (hepatocitos sanos y enfermos, y carga viral para el estudio de la dinámica del virus de la hepatitis C (VHC, con el modelo de la dinámica viral con alanina aminotransferasa (ALT. En términos del parámetro umbral que es el mismo para ambos modelos, se determina la existencia y estabilidad del estado de equilibrio endémico, así como la estabilidad global del estado de equilibrio del individuo sano. Por otro lado, se presenta un estudio experimental que muestra que es posible monitorear el daño hepático sin biopsias, mediante la estimación numérica de los parámetros de los modelos, considerando solamente mediciones de la carga viral, de los niveles de ALT y una valoración razonable del daño hepático pretratamiento.aThe standard model of three populations (healthy and unhealthy hepatocytes, and viral load for the study of the dynamics of hepatitis C virus (HCV, is compared with viral dynamic model with alanine aminotransferase (ALT. In terms of the threshold parameter that it’s the same for both models, the existence and local asymptotic stability of the endemically infected equilibrium steady state, and the global stability of the healthy individual equilibrium steady state are established. Furthermore, an experimental study is presented showing that it’s possible to carry out the monitoring of hepatic damage biopsies free by numerical parameter estimation, considering only viral load and ALT levels measurements and a reasonable assessment of pretreatment hepatic damage.

  15. Prostatic biopsy in the prostate specific antigen gray zone; La biopsia prostatica multipla nalla zona grigia dei valori dell'antigene prostatico specifico

    Energy Technology Data Exchange (ETDEWEB)

    Drudi, F. M.; Ricci, P.; Iannicelli, E.; Di Nardo, R.; Novelli, L.; Laghi, A.; Passariello, R. [Rome Univ. La Sapienza, Rome (Italy). Ist. di Radiologia II Cattedra; Perugia, G. [Rome Univ. La Sapienza, Rome (Italy). Dipt. di Urologia U. Bracci

    2000-02-01

    The main purpose of this study was to identify cases of undetected prostatic cancer in patients with normal findings at digital examination and transrectal US, and prostate specific antigen (PSA) values ranging 4-10 ng/mL. 290 patients were submitted to transrectal US and random bilateral prostatic biopsy; 3 samples were collected from each side of the gland using 16-Gauge thru-cut needles. Of the 290 patients who gave full informed consent, 34 people were selected whose age range was between 56 to 76 years (mean: 64). Inclusion criteria were PSA 4-10 ng/mL, PSAD cut-off 0.15, free/total PSA ratio 15-25%, and normal findings at digital examination and transrectal US. PSA velocity was calculated collecting 3 blood samples every 30 days for 2 months. 5 of the 34 selected patients (15%) had prostatic cancer, and 2 (6%) Pin (1 Pin 1 and 1 Pin 2). As for the other 27 patients, biopsy demonstrated 4 (12%) cases of prostatitis and 23 (62%) cases of BPH. PSA values increased in all patients with positive histology, versus only 6 (22%) of those with negative histology. Our findings confirm that prostatic biopsy can detect tumors also in areas which appear normal at transrectal US and digital examination, and that PSA rate increases in patients with positive histology. Finally, the actual clinical role of prostatic biopsy relative to all other diagnostic imaging techniques remains to be defined. [Italian] Si intende qui dimostrare la percentuale di neoplasie prostatiche sfuggite all'esplorazione rettale e all'ecografia transrettale nei pazienti convalori di antigene prostatico specifico tra 4 e 10 ng/ml. 290 pazienti sono stati sottoposti a ecografia transrettale e biopsia multipla (6 prelievi, ago da 16 Gauge) dopo consenso informato. Di questi sono stati selezionati 34: eta' tra 56 e 76 anni, eta' media 64 anni. Parametri di selezione: antigene prostatico specifico con valori tra 4 e 10ng/ml; densita' dell'antigene prostatico specifico con

  16. [Intrarectal povidone-iodine to reduce the risk of genitourinary infections after transrectal prostate biopsy].

    Science.gov (United States)

    Moreno-Palacios, Jorge; Espinosa-Guerrero, Alejandro; Torres-Anguiano, Juan Ramón; Montoya-Martínez, Guillermo; López-Samano, Virgilio; Serrano-Brambila, Eduardo

    2015-01-01

    Introducción: el objetivo de este estudio es comparar dos preparaciones distintas en pacientes sometidos a la toma de biopsias prostáticas transrectales (BPTR) y evaluar la prevalencia de infecciones genitourinarias (IGU). Métodos: se compararon dos grupos de pacientes con sospecha de cáncer de próstata sometidos a Biopsia Prostática Transrectal (BPTR): Con jalea lubricante endorrectal (grupo l, cohorte histórica) y con jalea lubricante más iodopovidona (grupo II, cohorte prospectiva). Se evaluaron las complicaciones a las tres semanas. Se realizó un análisis bivariado, calculando su OR (IC: 95 %) para determinar si la iodopovidona endorrectal adicional previa a la BPTR disminuye las IGU y otras complicaciones. Resultados: Se evaluaron 185 pacientes (Grupo I n = 86; grupo II n = 96). Tuvieron infección del tracto genitourinario el 45 y 25 % (OR: 0.4, IC: 0.2-0.9, p = 0.004); la fiebre se presentó en el 21 y 10 % respectivamente (OR: 0.42, IC: 0.1-0.9, p = 0.04). Conclusiones: Se observó una reducción en la presencia de infecciones genitourinarias en pacientes a quienes se aplicó en su preparación iodopovidona intrarrectal.

  17. Valor de la biopsia de glándulas salivales labiales en el diagnóstico de amiloidosis sistémica.

    OpenAIRE

    Delgado, Wilson

    2013-01-01

    En 78 pacientes con sospecha clínica de amiloidosis secundaria se tomaron igual número de biopsias de glándulas salivales labiales y 26 de encía. Así mismo se analizaron los resultados de 11biopsias renales, 4 de mucosa rectal y 1 de piel. La substancia amiloide fue detectada en todas las biopsias de glándulas salivales (100%),en tanto que en las biopsias de encía se le observó sólo en 4 casos (15%). Los resultados de las biopsias labiales en 42 pacientes control fueron negativos. En 11 pacie...

  18. Biopsia por aspiración y supresión con hormonas tiroideas en el diagnóstico de cáncer tiroideo: comparación con la cirugía en 77 nódulos hipocaptantes Fine-Needle aspiration biopsy and suppression with thyroid hormone in the diagnosis of thyroid carcinoma

    Directory of Open Access Journals (Sweden)

    Humberto Aristizábal

    1992-01-01

    Full Text Available Se estudiaron 77 pacientes con nódulos tiroideos hipocaptantes, demostrados por gamagrafía, por medio de biopsia tiroidea por aspiración y terapia supresiva con hormonas tiroideas durante 6 meses o más. Se realizó estudio ecográfico del nódulo antes de iniciar la terapia y seis meses después de estarla administrando. Todos fueron intervenidos porque en ninguno desapareció el nódulo con la terapia, a pesar de que se obtuvo supresión de la tirotrofina en plasma. La biopsia tiroidea por aspiración (BT A fue Interpretada en todos los pacientes como bocio coloide o nodular o neoplasia folicular. En contraste, en el estudio de la pieza quirúrgica 52 pacientes presentaron bocio nodular, multinodular o coloide; 16 tenían carcinomas (12 papilares y 4 foliculares y 9 tiroiditis de Hashimoto. Contrariamente a lo esperado se observó que 5 de loS carcinomas (31.3% disminuyeron de volumen durante el tratamiento hormonal; de acuerdo a la ecografía la disminución promedio fue 0.41 cm3. En cambio 4 de los 52 nódulos benignos (7.7% aumentaron de volumen, en promedio 3.7 cm3. Estos hallazgos sugieren que la prueba de supresión con hormonas tiroideas no es confiable para definir si una lesión es benigna o maligna. En el estudio quirúrgico se demostró que 20.8% (16/77 de los nódulos eran carcinomas. A la luz de estos datos la biopsia por aspiración no estableció por lo general el diagnóstico de carcinoma; por ello se debe recurrir a la cirugía aunque la biopsia sea negativa.

    Seventy-seven patients with cold thyroid nodules were studied with flne-needle aspiration biopsy and suppression with thyroid hormone. The volume of the nodule was calculated ultrasonographycally at the beginning of the study and after six months of oral therapy with thyroglobulin, at doses sufficient to maintain TSH at the low limits of the normal

  19. Biopsia Renal en receptores de Trasplante Renal: cuidados de enfermería y complicaciones

    Directory of Open Access Journals (Sweden)

    Esther Sanz Izquierdo

    Full Text Available Introducción: La biopsia renal percutánea es una herramienta fundamental para el manejo del paciente trasplantado renal. La prueba es primordial para detectar y/o prevenir cualquier disfunción en el injerto, siendo un procedimiento tanto diagnóstico como preconizador. Objetivo: Describir los cuidados de enfermería e identificar las complicaciones derivadas de la biopsia renal en los receptores de Trasplante Renal. Material y métodos: Estudio cuantitativo, descriptivo y transversal realizado en la Unidad de Trasplante Renal, Servicio de Nefrología, del 2008 al 2014. La población objeto de estudio son los receptores de Trasplante Renal (TR. La muestra está compuesta por 368 biopsias renales de seguimiento que ingresan para someterse a una biopsia renal. Los criterios de inclusión son ser mayores de 18 años, trasplantados y que han firmado el consentimiento informado. Se recogen datos sociodemográficos, clínico-asistenciales y complicaciones post-biopsia renal. Resultados: Desde 1980 hasta el 2014 se han llevado a cabo 1868 TR, de 2008 a 2014 se estudiaron 368 biopsias de seguimiento. Se monitoriza la Tensión Arterial y la coagulación pre biopsia. Tras el procedimiento, se controla la presencia de sangrado por micción y constantes vitales. Inicialmente el reposo absoluto era de 24 h, a partir de 2014 se reduce a 6 horas, recomendando reposo relativo al alta, las complicaciones fueron mínimas. Conclusiones: Los resultados indican que la biopsia renal es un procedimiento eficaz, con escasas complicaciones. Destacar el papel de enfermería en la detección precoz de complicaciones.

  20. Ganglio centinela en cáncer de mama: biopsia selectiva comparada con linfadenectomía axilar. Seguimiento a largo plazo Sentinel ganglion in breast cancer: selective biopsy compared with axillary lymphadectomy

    Directory of Open Access Journals (Sweden)

    E. Goñi

    2009-12-01

    Full Text Available Fundamento. La biopsia selectiva del ganglio centinela (BSGC ha reemplazado a la linfadenectomía axilar (LA, como procedimiento de elección, en el estadiaje del cáncer de mama en estadios iniciales y axila clínicamente negativa. El objetivo de este trabajo es comparar la supervivencia global y libre de eventos de aquellas pacientes a las que se realizó, en el periodo de validación de la técnica, BSGC seguida de LA respecto a las que se practicó BSGC y LA si el ganglio centinela (GC presentaba metástasis. Material y métodos. Se han incluido 148 pacientes, 81 pertenecientes al periodo de validación y 67 al grupo de aplicación clínica. El radiocoloide se administró intra-peritumoralmente, obteniéndose imágenes hasta la visualización del GC, posteriormente en la intervención quirúrgica se procedió a su identificación y extirpación. Resultados. En el grupo de validación, la eficacia de la técnica ha sido del 92,5%, la sensibilidad del 95,6% y la tasa de falsos negativos del 4%. De las 81 pacientes, 75 se encuentran libres de enfermedad (92,6%. De las 67 pacientes pertenecientes al grupo de aplicación clínica, 63 (94% viven libres de enfermedad. Ninguna paciente ha presentado recurrencia ganglionar axilar. Conclusiones. En la validación de la técnica hemos obtenido unos valores que se hallan dentro de las exigencias de calidad generalmente aceptadas. Con una media de seguimiento de 6 años no hemos observado recurrencia axilar en ninguno de los dos grupos. No existe diferencia estadísticamente significativa en la supervivencia global y libre de eventos entre ambos grupos.Background. Selective biopsy of the sentinel ganglion (SBSG has replaced axillary lymphadectomy (AL as the procedure of choice in staging breast cancer in its initial stages and in clinically negative axilla. The aim of this study is to compare global event-free survival of those patients subjected to SBSG followed by AL, during the period of validation of

  1. UTILIDAD DE LA BIOPSIA RECTAL EN EL DIAGNÓSTICO DEL PACIENTE PEDIÁTRICO CON ESTREÑIMIENTO. EXPERIENCIA DE CINCO AÑOS EN UN CENTRO COLOMBIANO DE REFERENCIA The usefulness of rectal biopsy when diagnosing paediatric patients suffering from straining. Five year-experience in a Colombian reference centre (public hospital

    Directory of Open Access Journals (Sweden)

    Juan Carlos-Hiromi López T

    2011-09-01

    Full Text Available Antecedentes. El estreñimiento en la edad pediátrica es un problema de alta prevalencia que afecta aproximadamente al 8% de los niños. La mayoría de los pacientes no tienen una patología estructural de base y sólo en un pequeño porcentaje se encuentra una causa orgánica como las disganglionosis intestinales también llamadas neuropatías entéricas; es en estos casos donde la biopsia rectal juega un papel primordial para el diagnóstico. Objetivos. Determinar la incidencia de las neuropatías entéricas y las características de las biopsias colorectales realizadas para estudio del paciente con estreñimiento en el laboratorio de patología de la Fundación Hospital de la Misericordia en un periodo de cinco años. Material y métodos. Se revisaron y clasificaron las biopsias rectales remitidas para estudio por estreñimiento. Resultados. Se evaluaron 854 biopsias correspondientes a 272 casos, con un promedio de 3,13 muestras por paciente. En 183 casos se encontró histología normal (67,29%, en cincuenta y seis se estableció el diagnóstico de aganglionosis o enfermedad de Hirschsprung (20,59%, en dos el de displasia neuronal intestinal (DNI (0.74%, 8 pacientes se consideraron sospechosos de DNI (2.94% y los 22 restantes (8,1% fueron informados como material inadecuado para el estudio de neuropatía entérica. Conclusiones. Las biopsias rectales son un método útil para el diagnóstico de las neuropatías entéricas, sin embargo un porcentaje de ellas no permiten una adecuada interpretación. La disganglionosis más frecuente en esta serie fue la enfermedad de Hirschsprung con 56 casos, seguida por la displasia neuronal intestinal con tan sólo dos pacientes.Background. Straining occurs in around 8% of paediatric aged children. Most patients do not have base structural pathology and an organic cause, such as enteric neuropathy (also called Hirschsprung's disease or intestinal aganglionosis, is only found in a small percentage of them

  2. Correlación anatomopatológica entre la biopsia preoperatoria y la pieza quirúrgica de quistes dentigeros y queratoquistes odontogenicos

    OpenAIRE

    Mordcovich Maldonado, Gonzalo

    2014-01-01

    En este estudio se analizó la correlación entre las biopsias preoperatoria y posoperatoria de 15 pacientestratados con quistes dentígeros (QD) y 15 pacientes tratados con queratoquistes (QQ). De esta manera se comparó cual de las dos patologías es más propensa a presentar transformaciones histopatológicas, su relación con el sexo, la edad, el mayor número de recidivas y la localización anatómica más frecuente Objetivo: se realizó el estudio de las biopsias preoperatorias (biopsia por imcisión...

  3. Fisher criteria vs. thyroid aspiration citology in the diagnosis of hashimoto's thyroiditis Valor de cuatro de los criterios de Fischer comarados con la biopsia tiroidea por aspiración en el diagnóstico de la tiroiditis de Hashimoto

    Directory of Open Access Journals (Sweden)

    Constanza Díaz González

    1991-02-01

    Full Text Available

    One hundred and forty one patients with diffuse goiter were studied In order to evaluate four of Fisher's criteria for the diagnosis of Hashimoto's thyroiditis and to compare them with the result of thyroid aspiration biopsy. The following criteria were Included in the analysis: a physical characteristics of the gland; b appearance of the radioisotope scan; c plasma TSH concentration; d serum tilters of antithyroid antibodies. It was found that neither criteria was satisfactory in terms of sensitivity or specificity when compared with the result of the aspiration cytology. Ac. cordingly, we favor the use of the latter provided that adequate material is obtained and that an expert reading is performed.

    Se hicieron estudios clínico y de laboratorio y biopsia tiroidea por aspiración a 133 mujeres y 8 hombres con bocio difuso, de la Consulta Externa del Instituto de Seguros Sociales de Medellín, con el fin de comparar el valor diagnóstico de cuatro de los cinco criterios de Fisher con el de dicha biopsia, en la tiroiditis de Hashimoto. El diagnóstico citológico fue bocio simple (nodular, multinodular O coloide en 130 casos (92.2% y tiroiditis de Hashimoto en 11 (7.8%. Se aplicó la prueba tamiz a los criterios de Fisher, aisladamente O en grupos, con resultados deficientes en cuanto a sensibilidad y especificidad. Los criterios analizados fueron: a glándula moderadamente crecida, difusa y firme; b captación tiroidea Irregular; c TSH plasmática elevada; y d anticuerpos antitiroideos positivos a muy altas diluciones (≥:1 :25.000. La captación tiroidea Irregular tuvo la mayor sensibilidad (90% pero su especificidad fue sólo 11 %. En contraste, la sensibilidad y la especificidad de los títulos altos de anticuerpos antimicrosomales fueron 78% 71 %, respectivamente.

  4. Determinación de la utilidad de la relación APE l/t (Antígeno Prostático Específico libre sobre el total en pacientes con sospecha de cáncer de próstata estudiados por biopsia ecográfica endorrectal Utility of Free/Total Serum Prostate-Specific Antigen Ratio in prostatic cancer studied with endorectal ultrasound biopsy

    Directory of Open Access Journals (Sweden)

    Alberto Marangoni

    2008-09-01

    Full Text Available Introducción: Los marcadores tumorales son importantes al momento de decidir la realización de biopsias para el diagnóstico de cáncer de próstata. El objetivo de este trabajo es evaluar la exactitud diagnóstica del APE libre como marcador tumoral en casos de pacientes con sospecha de cáncer prostático en su relación con el APE total (APEL/T y determinar un valor de corte ajustado. Material y Método: En total, fueron evaluados 248 pacientes de entre 38 y 88 años de edad, en un período comprendido entre noviembre de 2001 y junio de 2007, con un análisis del APE libre, identificación de la presencia de un área hipoecogénica como ayuda diagnóstica y un análisis anatomopatológico para confirmación pospunción prostática endorrectal, realizado en forma prospectiva. Resultados: La identificación de pacientes con cáncer de próstata a través de la sospecha por el APE libre es relativa pero puede ser potenciada con otros hallazgos. Un 23,3% de pacientes con APEL/T por debajo de 0,20 presentaron biopsias positivas, pero, con un valor de 0,14, el porcentaje fue del 60%. Discusión: La identificación de pacientes para ser estudiados mediante Biopsia Prostática Endorrectal (BPE es un problema de la práctica diaria en los consultorios de Urología. Debido a que la BPE es un procedimiento diagnóstico medianamente invasivo y no exento de morbilidad, es que se debería ajustar su indicación. La relación APEL/T debe ser considerada en este contexto con mayor importancia. Conclusión: La identificación de valores alterados de la relación APE L/T con un valor de corte ajustado a 0,14 puede ayudar en el diagnóstico presuntivo de cáncer de próstata y a la elección de pacientes para biopsia a fin de ahorrar biopsias innecesarias.Introduction: The tumor markers are important to decide to perform biopsies in the prostate cancer diagnosis. The goal of this article is to evaluate the diagnosis precision of FPSA (Free Prostatic Specific

  5. Epidemiología retrospectiva y análisis de las características múltiples del carcinoma espinocelular de la mucosa bucal con estudio histopatológico de biopsias

    OpenAIRE

    Baudo, Judith Ethel

    2000-01-01

    La Organización Mundial de la Salud ha venido estableciendo parámetros de estudio histológico y clasificaciones de las enfermedades precancerosas y carcinoma oral. Ha efectuado distintas revisiones con el fin de implicar los conceptos para los patólogos de todas las naciones. El objetivo general de este trabajo fue actualizar los aspectos epidemiológicos, clínicos, condicionantes, etiológicos, y de diagnóstico, pronóstico y tratamiento del carcinoma a células escamosas de la mucosa bucal. ...

  6. Estudio de la subestimación histológica e incidencia de falsos negativos en biopsias de mama por vacío con guía estereotáxica Evaluation of the histological underestimation and incidence of false-negative using vacuum assisted breast biopsy and stereotactic equipment

    Directory of Open Access Journals (Sweden)

    Javier Rodríguez Lucero

    2011-06-01

    Full Text Available Objetivo. Comparar los resultados histológicos en biopsias percutáneas bajo guía mamográfica y sistema de vacío con los resultados anatomopatológicos de las ulteriores cirugías. Evaluar falsos negativos al control mamográfico tras seis meses del procedimiento. Materiales y Métodos. Entre mayo de 2008 y mayo de 2010 en 148 mujeres se realizaron 157 biopsias. Del total biopsiado, se obtuvieron 137 grupos cálcicos, 6 nódulos, 9 densidades focales asimétricas y 5 blancos mixtos. Se colocaron clips en 85 blancos (85/157; 54,14%. Se compara la histología obtenida por punción con la surgida de las cirugías para analizar discrepancias o subestimaciones. En las biopsias negativas se indica control mamográfico a los 6 meses para evaluar falsos negativos. Resultados: En 41 pacientes (41/157; 27,70% se decidió completar con cirugía por el resultado histológico de la punción. Accedimos al resultado histológico quirúrgico en 34 casos, observando una concordancia entre la anatomía patológica de la punción y la quirúrgica en los 34 casos. De los 116 casos en los que no se realizó cirugía, logramos seguir mamográficamente a 67 mujeres reconociendo 1 falso negativo (1/67; 1,49% vinculado a un grupo cálcico. Conclusiones. Encontramos una correlación histológica en el 100% de los casos en los que accedimos a la anatomía patológica quirúrgica y pudimos reconocer durante el seguimiento posbiopsia 1 falso negativo. En el grupo que pudo evaluarse no hallamos subestimación. El falso negativo fue en una de las primeras pacientes biopsiadas, por lo que podría interpretarse como probable causa la falta de experiencia con el sistema. Creemos conveniente contar con grupos poblacionales más numerosos para obtener mayores conclusiones.Objective. To compare the histological findings in percutaneous biopsies under stereotactic guidance and vacuum assisted breast biopsy, with the pathological results from subsequent surgery. To evaluate false

  7. Biopsia por aspiración con aguja fina (BAAF) para el diagnóstico de linfoma no hodking cutáneo asociado a HTLV I-II. Presentación de caso.

    OpenAIRE

    Núñez Carrión., Ericka Cecilia

    2010-01-01

    INTRODUCCIÓN: El HTLV-1 es el primer retrovirus oncógeno humano que fue aislado por vez primera. Más tarde se demostró que el virus del linfoma leucemia de células T humanas (HTLV-1) era el agente causal de la Leucemia/linfoma de células T del adulto (ATL). EL HTLV-1 es más común en Japón y en el Caribe que en los Estados Unidos. También se ha descrito posteriormente en varios países latinoamericanos incluyendo Perú. El HTLV-1 pertenece a la familia de los retrovirus humanos, con tropismo pos...

  8. Cambios histológicos en muestras de agrandamientos gingivales obtenidas a través de biopsias con electrobisturí y bisturí convencional Histological changes in samples of gingival overgrowth biopsies obtained through conventional scalpel and electro surgical scalpel

    Directory of Open Access Journals (Sweden)

    A. Herrera Herrera

    2012-06-01

    Full Text Available Antecedentes: Es poco lo que se dice en la literatura sobre cambios histológicos observados en la encía y aun menos comparándolo en caso de agrandamiento gingival obtenido de tejidos humanos. Al realizar estos recortes surge la pregunta si existe alguna diferencia histológica al comparar las muestras obtenidas con electrobisturí y bisturí convencional. Métodos: Se implementó un estudio descriptivo comparativo, sobre 21 pacientes obteniendo 90 muestras. La asignación de los sitios quirúrgicos para cada uno de los tratamientos se hizo con la estrategia de control cruzado, evaluando ambos tratamientos en el mismo sujeto (electrobisturí y bisturí convencional, en forma aleatoria en ambas hemiarcadas. Los datos se incluyeron en una base de datos en Excel, se analizaron en un software estadístico STATA 9.1. Se utilizó el test exacto de Fischer, con significancia p=0,05. Resultados: Se observó carbonización y coagulación del colágeno en el 72,7% siendo superior en las muestras obtenidas con electrobisturí en el tejido conectivo, el 79,5% de diferencia de carbonización siendo superior con el electrobisturí en el tejido epitelial. Con respecto al bisturí convencional en el tejido conectivo en un 95,6% esta inflamación estaba mediada por linfocitos y células plasmáticas y solo en un 17,8% se encontró presencia de neutrófilos y con respecto al electrobisturí en el tejido conectivo el 100% de las muestras presentaron inflamación, el cual estaba constituido por un 97,8% de linfocitos y células plasmáticas, solo un 37,8% de neutrófilos. Conclusiones: Se observaron diversos fenómenos histológicos en las biopsias de encía obtenidas tanto con bisturí convencional como con electrobisturí que ayudan a la comprensión de las ciencias básicas para futuras investigaciones y así poder llegar a la práctica clínica. Se observaron daños en las biopsias tanto en los cortes de bisturí convencional como con los cortes de bistur

  9. HIPERPLASIA ENDOMETRIAL: ANÁLISIS DE SERIE DE CASOS DIAGNOSTICADOS EN BIOPSIA ENDOMETRIAL

    OpenAIRE

    García Ayala,Ernesto; Cárdenas Mastrascusa,Laura; Sandoval Martínez,Diana; Mayorga Anaya,Henry

    2010-01-01

    Antecedentes: La hiperplasia endometrial es una entidad en la que existe una proliferación de glándulas endometriales de tamaño y forma irregular, con mayor proporción de glándulas sobre el estroma, a consecuencia de una excesiva exposición a los estrógenos. Aproximadamente, en el 15% de legrados/biopsias endometriales de mujeres postmenopausicas con cuadro clínico de hemorragia uterina anormal, se diagnostica esta entidad. Objetivo: Describir la incidencia y hallazgos histopatológicos en leg...

  10. Resultados de biopsia guiada por tomografía axial computarizada en el síndrome de destrucción vertebral, evaluados en dos instituciones distintas

    OpenAIRE

    Barón Zarate-Kalfopulos; José Ernesto García-Valerio; Guadalupe Sánchez-Bringas; Luis Miguel Rosales-Olivares; Armando Alpizar-Aguirre; Alejandro Reyes-Sánchez

    2013-01-01

    OBJETIVO: Comparar resultados de biopsias vertebrales guiadas por tomografía axial computarizada, reportados por dos servicios de Anatomía Patológica distintos en pacientes con síndrome de destrucción vertebral para confirmar confiabilidad y utilidad en el diagnóstico. MÉTODOS: Se obtuvieron muestras de tejido de 21 pacientes en el periodo comprendido del 1 de marzo al 15 de julio del 2011 con el diagnóstico del síndrome de destrucción vertebral y a quienes se les realizó biopsia guiada por t...

  11. Biopsia por punción con aguja fina sin aspiración en el diagnóstico prequirúrgico del nódulo del tiroides Fine needle biopsy without aspiration in the presurgical diagnosis of thyroid nodule

    Directory of Open Access Journals (Sweden)

    Francisco Ochoa Torres

    2001-12-01

    Full Text Available Se estudió un grupo de 100 pacientes operados de nódulo único del tiroides en el Servicio de Cirugía General del Hospital “Cmdte. Manuel Fajardo”, para validar el método de la biopsia por punción con aguja fina sin aspiración (citopunción en el diagnóstico prequirúrgico de esa afección. A cada paciente se le realizó una citopunción con aguja No. 25 antes de la intervención quirúrgica; los resultados se clasificaron en negativos (benignos y positivos (malignos y sospechosos y la histología posoperatoria, en benigna y maligna, según los intereses de nuestro trabajo y de criterios preestablecidos en el Departamento de Anatomía Patológica del hospital. El 100 % de las muestras fue útil para diagnóstico con una correspondencia entre citopunción e histología del 83 %. Los valores de los indicadores de validación fueron: sensibilidad: 76 %, especificidad: 85 %, valor predictivo positivo: 57 %, valor predictivo negativo: 93 % y eficacia general del método: 85 %. Concluimos que la citopunción es un método diagnóstico útil en el nódulo único del tiroides y que logra iguales resultados que la BAF, pero la primera es más recomendable por ser de más fácil aplicación, menos traumático y más económico.A group of 100 patients operated on of thyroid nodule at the Service of General Surgery of “Comandante Manuel Fajardo” Hospital was studied aimed at validating the method of biopsy by fine needle puncture without aspiration (cytopuncture in the presurgical diagnosis of this disease. Every patient underwent cytopuncture with needle No. 25 before the operation. The results were classified into negative (benign and positive (malignant and suspected, and postoperative histology into benign and malignant, according to the interests of our investigation and to the criteria preestablished at the Department of Pathological Anatomy of the hospital. 100 % of the samples were useful for the diagnosis with a correspondence

  12. Estudio prospectivo sobre la utilidad de la ecografía de control tras la realización de pruebas invasivas hepáticas: biopsia hepática y punción aspiración con aguja fina (PAAF A prospective study about the usefulness of ultrasonographic monitoring after invasive liver procedures: liver biopsy and fine-needle aspiration (FNA

    Directory of Open Access Journals (Sweden)

    E. Carrera Alonso

    2007-03-01

    Full Text Available Objetivo: establecer si es necesario realizar una ecografía de control a todos los pacientes sometidos a una biopsia hepática o una punción aspiración con aguja fina, para detectar posibles complicaciones con o sin repercusión clínica. Material y métodos: tras la realización de una biopsia hepática o una punción aspiración con aguja fina según el protocolo habitual, se mantiene al paciente en observación durante 24 horas, realizándose en ese momento una ecografía a todos los pacientes aunque no presenten datos clínicos de complicación. Resultados: se llevaron a cabo 298 biopsias hepáticas y 98 punciones mediante aguja fina. Presentaron complicaciones un total de 37 pacientes (9,34%, de las cuales 36 (9,09% fueron complicaciones menores en forma de dolor, síncope vasovagal o hemorragia leve y 1 (0,25% complicación mayor en forma de hemorragia grave. De las 396 exploraciones tan sólo uno de los casos presentó una complicación detectada en la ecografía (hematoma intraparenquimatoso encontrándose asintomático. Conclusiones: la baja incidencia de complicaciones, que cursan de forma asintomática, y la buena evolución de las mismas hacen poco rentable la realización de ecografía de control tras la realización de dichas técnicas diagnósticas, siendo necesaria tan sólo en el caso de sospecha clínica de complicación.Objective: to determine the need to perform ultrasound scans to all patients after liver biopsy or fine-needle aspiration (FNA in order to detect complications with or without symptoms. Material and methods: after liver biopsy or FNA using a regular protocol the patient is observed for 24 hours at the hospital, and all patients undergo an abdominal sonography at that time even in the absence of evident complications. Results: 298 liver biopsies and 98 FNAs were performed. There were complications in 37 patients (9.34%: 36 (9.09% were minor complications such as pain, vasovagal episodes, or small bleeding

  13. Histología de la biopsia hepática, enfoque para el clínico

    Directory of Open Access Journals (Sweden)

    Fernando Brenes-Pino

    2008-11-01

    Full Text Available La biopsia hepática es necesaria para la evaluación de la hepatitis crónica. Su utilidad reside en la valoración del grado de inflamación y fibrosis del paciente con hepatitis crónica. La utilización de un sistema semicuantitativo para la clasificación de las biopsias de hepatitis crónicas es necesaria con el fin de tener parámetros menos subjetivos, y para comparar la evolución ante una potencial terapia. Se establece una puntuación semicuantitativa que determina la graduación y el estadiaje. Se considera importante tener como mínimo para la valoración de una biopsia hepática, la presencia al menos de 3-5 espacios porta y realizar tinciones de rutina como hematoxilina eosina, tricromico, reticulita y orceina. Se considera básico para la definición de los tratamientos la actividad inflamatoria y el estadio de la fibrosis, apoyando a la parte clínica, bioquímica y de biología molecular del virus de hepatitis B.

  14. Amiloidosis Secundaria o Sistemática: Diagnóstico por la Biopsia Oral y por Patología Clínica en Relación con Pacientes Portadores de Enfermedades Crónicas en Especial TBC Crónica

    OpenAIRE

    Gutierrez Manay, Juan J.; Uriarte Mora, Carlos; Cuadrao Zavaleta, Luis; Rodriguez Alfaro, Miguel; Romero Rivas, Roberto; Gutierrez Portocarrero, Ledda Candy

    2014-01-01

    Tiene caracteres investigatorios ver el depósito anormal de sustancial amiloide en la mucosa oral, mediante la biopsia inocua de las áreas lateral gingival y dérmica (psoriatica) en 20 casos patológicos de pacientes enfermedad inflamatoria crónica, de larga evolución. Así como la aplicación de una adecuada historia clínica implementada en todos los pacientes en los diferentes hospitales y centros asistenciales donde practicando las incisiones operatorias, donde comunicamos y solicitamos el ad...

  15. Biopsia por punción, en los tumores del seno maxilar

    OpenAIRE

    Cleves, Carlos A.; Mendoza, César

    2011-01-01

    Gracias a los adelantos actuales de los exámenes citológicos, en relación con la determinación de los procesos tumorales malignos, contamos en nuestra especialidad con un medio más para el diagnóstico de los tumores de los senos maxilares.Al examen clínico y radiológico podemos agregar hoy día el examen citológico, el cual tiene la enorme ventaja de ser de fácil ejecución, sin los inconvenientes que por el traumatismo se presenten cuando se practica la biopsia del tumor haciendo una trepanaci...

  16. Evaluation of WGA and Concanavalin A (Con A lectin as biomarkers of hepatosplenic schistosomiasis in human biopsies with no evidence of egg-granuloma system Avaliação das lectinas WGA e Con A como biomarcadoras de esquistossomose hepatoesplênica em biopsias humanas sem evidência do sistema ovo-granuloma

    Directory of Open Access Journals (Sweden)

    Moacyr Jesus Barreto de Melo Rêgo

    2013-06-01

    Full Text Available Introduction: Colonic lesions are predominant in patients with schistosomiasis. However, carbohydrate alterations in colonic schistosomiasis remain unclear. Lectin-ligands allow us to identify changes in the saccharide patterns of cells. Methods: Biopsies of descending and rectosigmoid colon of patients were submitted to WGA and Con A lectin histochemistry. Results: WGA stained stroma and gland cells of descending colon and rectosigmoid tissues in a granular strong cytoplasmatic pattern in schistosomiasis specimens differing from normal control and Con A failing to recognize all samples analyzed. Conclusions: WGA ligands are expressed differently in patients with hepatosplenic schistosomiasis and no evidence of egg-granuloma system. Introdução: Lesões do cólon são predominantes em pacientes com esquistossomose, entretanto alterações dos carboidratos no cólon com esquistossomose permanecem desconhecidas. Ligantes de lectinas permitem a identificação das mudanças no padrão dos carboidratos celulares. Métodos: Biópsias do cólon descendente e sigmóide dos pacientes foram submetidas a histoquímica com as lectinas WGA e Con A. Resultados: WGA marcou o estroma dos tecidos das células glandulares do cólon descendente e sigmóide com um padrão citoplasmático intenso e granular em espécimes com esquistossomose diferindo do controle normal e da Con A, a qual não reconheceu nenhum tecido estudado. Cólon sem esquistossomose não apresentou marcação. Conclusões: ligantes de WGA são diferentemente expressos em pacientes com esquistossomose hepatoesplênica sem evidência de sistema ovo-granuloma.

  17. Aportaciones de la biopsia muscular al entrenamiento deportivo

    OpenAIRE

    Subiela, J.V.; Torres, S.H.

    2010-01-01

    La biopsia muscular por aguja es una técnica bastante asequible, que ha permitido conocer las características de los diferentes tipos de fibras del músculo esquelético, su potencial metabólico y su gran capacidad de adaptación a los distintos estímulos de entrenamiento. Aunque el modelo de distribución de las fibras en los distintos músculos parece estar determinado genéticamente, se ha observado la transformación reversible de los tipos de fibras pertenecientes a un mismo músculo, inducida por ...

  18. Supervivencia del injerto renal según la categoría de Banff 2013 en biopsia por indicación

    Directory of Open Access Journals (Sweden)

    Carlos Arias-Cabrales

    2016-11-01

    Conclusiones: La clasificación de Banff 2013 permite el diagnóstico histológico en el 95% de las biopsias por indicación. La categoría 6 es la más frecuente, pero se observa una modificación en la histopatología predominante según el tiempo postrasplante. Los cambios mediados por anticuerpos se asocian con peor supervivencia del injerto.

  19. A comparative study of two histological techniques for the identification of cytomegalovirus infection in colorectal biopsies from patients with chronic inflammatory bowel disease Estudio comparativo entre dos técnicas histológicas para el diagnóstico de infección por citomegalovirus en biopsias colorrectales de pacientes con enfermedad inflamatoria intestinal crónica idiopática

    Directory of Open Access Journals (Sweden)

    M. L. de Castro

    2009-10-01

    ímica (IHC. Nuestro objetivo fue comparar la sensibilidad de ambas técnicas histológicas para establecer este diagnóstico. Pacientes y métodos: estudio caso-control, identificando en el periodo 1997-2007 aquellos pacientes CMV positivos con HE o IHQ. Sus controles fueron apareados por edad y año de diagnóstico de CMV en los casos. Se realizaron ambas técnicas en las biopsias de casos y controles obtenidas 6 meses antes y tras su inclusión en el estudio. En el análisis estadístico consideramos significativos los valores de p < 0,05. Resultados: encontramos infección por CMV en 10 pacientes. Estos sujetos presentaban más frecuentemente una EII resistente o dependiente de esteroides (p = 0,03 y un mayor número de biopsias de colon (p = 0,03. De 97 biopsias analizadas, 12 fueron HE-negativas e IHC-positivas y 3 mostraron resultados inversos. La sensibilidad de HE fue 58,6% IC95 (38,9-78,3 y para IHQ 89,7% IC95 (76,8-100. No encontramos una buena concordancia entre ambas técnicas histológicas: kappa 0,55 IC95 (0,36-0,75. La positividad para CMV se asoció al uso de más de un fármaco inmunosupresor, OR 13,5 IC95 (1,2-152,2. El tratamiento antiviral fue útil en la EII refractaria o dependiente de esteroides. Conclusiones: la IHQ posee una sensibilidad superior a HE (30% para el diagnóstico de infección por CMV en la EII, no existiendo buena concordancia entre ambas técnicas histológicas.

  20. Evaluacion de la biopsia transpedicular guiada por TAC Avaliação da biópsia transpedicular guiada por TC Evaluation of transpedicular percutaneous biopsy guided by CT

    OpenAIRE

    Luis Miguel Rosales Olivarez; Hugo Rolando Nieto Sandoval; Armando Alpízar Aguirre; Barón Zárate Kalfopulos; María Guadalupe Sánchez Bringas; Alejandro Antonio Reyes Sánchez

    2012-01-01

    OBJETIVO: Valorar la utilidad de la biopsia transpedicular percutánea guiada por Tomografía Axial Computarizada en conjunto con la sistematización de estudios como pruebas diagnósticas de la etiología de la destrucción vertebral. MÉTODOS: Estudio de serie de casos prospectivo transversal de 21 pacientes a los que se les realizó biopsia transpedicular percutánea guiada por Tomografía Axial Computarizada y estudios de laboratorio y gabinete de marzo a julio del 2011, para evaluar su utilidad en...

  1. Biopsia cerebral a mano alzada guiada por tomografía Cerebral biopsy by a handfree procedure

    Directory of Open Access Journals (Sweden)

    Juan Carlos Arango

    1998-03-01

    Full Text Available Se presenta la experiencia del Servicio de Neurocirugía del Hospital Universitario San Vicente de Paúl con un procedimiento alternativo para realizar una biopsia cerebral, el cual se lleva a cabo a mano alzada y guiado por tomografía sin utilizar un marco estereotáxico. Se resalta su utilidad en los casos de lesiones supratentoriales y con tamaño mayor de 3 centímetros, en centros donde no se disponga de los métodos estereotáxicos tradicionales. We report the experience at the Neurosurgery Service, Saint Vincent's University Hospital (Medellín, Colombia with a hand free procedure for performing brain biopsies, without stereotactical frames. It is considered useful in supratentorial lesions larger than 3 cm, in places lacking stereotactical technology.

  2. Técnicas de biopsia para el diagnóstico de lesiones mamarias no palpables Biopsy techniques for the diagnosis of non-palpable mammary lesions

    Directory of Open Access Journals (Sweden)

    L. Pina

    2004-12-01

    Full Text Available Ante una lesión mamaria no palpable que precise una biopsia diagnóstica debe valorarse el método de guiado idóneo para acceder a la misma. En la actualidad se emplean tres métodos: la estereotaxia (fundamentalmente en casos de microcalcificaciones, la ecografía (sobre todo en los nódulos y la resonancia magnética (para lesiones no visibles mediante los anteriores sistemas. El siguiente paso es elegir la técnica de biopsia más adecuada. La técnica más clásica y fiable es la biopsia quirúrgica con marcaje previo con un arpón metálico, pero tiene los inconvenientes de ser una técnica agresiva para el diagnóstico de la patología benigna, además de presentar un alto coste. Como alternativas se han desarrollado múltiples sistemas de punción. La punción con aguja fina es de fácil realización técnica y puede dar buenos resultados en los nódulos mamarios, pero la existencia de resultados falsos positivos y negativos han limitado progresivamente su utilización. Como alternativa, los sistemas de biopsia con aguja gruesa han permitido la obtención de múltiples cilindros con gran fiabilidad diagnóstica, sobre todo en el caso de los nódulos mamarios. Sin embargo, su empleo en las microcalcificaciones continúa mostrando resultados falsos negativos. El advenimiento de los sistemas de biopsia asistida por vacío ha permitido la obtención de cilindros de mayor calidad, mejorando claramente los resultados de los sistemas anteriores, sobre todo en los casos de microcalcificaciones. Por último, los sistemas de biopsia escisional percutánea mediante cánulas de hasta 22 mm de diámetro consiguen la extracción completa de lesiones de tamaño inferior al de la cánula, con una fiabilidad similar al de la biopsia quirúrgica.Facing a non-palpable mammary lesion requiring a diagnostic biopsy, consideration must be given to the most suitable guiding method for obtaining the latter. Three methods are employed at present: stereotaxy

  3. Detección inmunohistoquímica de la proteína L1 de Virus Papiloma Humano (HPV) de alto riesgo en citologías y biopsias de cuello uterino

    OpenAIRE

    Toro, Morelva; Llombart Bosch, Antonio

    2005-01-01

    Para confirmar la detección inmunohistoquímica de la proteína L1 de HPV de alto riesgo, tanto en citologías con anormalidades en células epiteliales como en biopsias con diagnóstico de carcinoma epidermoide cervical, se seleccionaron aleatoriamente: 11 citologías cervicales del año 2004 con interpretación citológica de anormalidades en células escamosas incluyendo: células escamosas atípicas y lesión intraepitelial escamosa de bajo y alto grado y 50 biopsias de cérvix con carcinoma epidermoid...

  4. Mapeo linfático y biopsia del ganglio centinela en cáncer de pene. Estudio de factibilidad y reporte preliminar

    OpenAIRE

    Narciso Hernández-Toris; Joel Quintero-Becerra; José Francisco Gallegos-Hernández; Ramiro Flores-Ojeda; Isabel Alvarado-Cabrero; Donaciano Flores-López; Pablo Pichardo-Romero

    2007-01-01

    La mayoría de los pacientes con carcinoma epidermoide invasor de pene no tiene metástasis ganglionares inguinales al momento del diagnóstico; en 50 % de los ganglios palpables la causa es inflamatoria. El tratamiento del cáncer peneano implica resección del tumor primario y linfadenectomía inguinal, sin embargo, la morbilidad derivada del procedimiento es alta y la utilidad cuestionable en pacientes sin metástasis en ganglios disecados. El mapeo linfático con biopsia del ganglio centinela (ML...

  5. Biopsia en enfermedad intersticial pulmonar Lung biopsy for the diagnosis of interstitial lung disease

    Directory of Open Access Journals (Sweden)

    Silvia Quadrelli

    2007-12-01

    Full Text Available El objetivo del presente estudio fue determinar el rédito diagnóstico y los factores asociados a mayor morbimortalidad en la biopsia quirúrgica de pulmón en pacientes con enfermedad intersticial difusa. Se analizaron en forma retrospectiva los registros clínicos de 71 pacientes. Se registraron complicaciones en 16 pacientes (22.5%. La mortalidad operatoria fue 11.2%. Los pacientes en quienes la biopsia se realizó por videotoracoscopia (n = 52 y por toracotomía (n = 17 tuvieron la misma duración de estadía en terapia intensiva y de estadía hospitalaria. La tasa de complicaciones (22.2% vs. 21.0%, p = 1.0000 y la mortalidad (9.2 vs. 15.7%, p = 0.2738 no fueron diferentes. Ocho pacientes murieron dentro de los 30 días. La prevalencia de inmunosupresión (4/8 vs. 9/63, p = 0.0325 fue significativamente superior en el grupo de pacientes fallecidos. Estos pacientes tuvieron valores preoperatorios más elevados de urea (50 ± 20.1 mg/dl vs. 31.2 ± 10.3 mg/ dl, p = 0.0013 y menores valores de saturación de O2: 82.7 ± 14.8% vs. 92.8 ± 3.4%, p = 0.0009. En los 11 pacientes con iniciación aguda la mortalidad fue significativamente más elevada (36.3% vs. 7.1%, p = 0.0223. La biopsia aportó un diagnóstico específico en 100% de los pacientes y cambió la estrategia terapéutica en 66.7%. En conclusión, la biopsia de pulmón por vía toracoscópica es un procedimiento útil y seguro en los pacientes con enfermedad intersticial difusa del pulmón. Sin embargo, en el grupo de pacientes inmunocomprometidos, con cuadros de presentación aguda y con insuficiencia respiratoria preoperatoria, la mortalidad es elevada y deben balancearse muy críticamente los riesgos contra los beneficios en ese grupo de enfermos.The objective of this study was to determine the morbidity, mortality and diagnostic yield of video assisted thoracoscopy (VATS and thoracotomy lung biopsy in interstitial lung disease (ILD. Clinical records of 71 patients were

  6. Sobre-expresión de la proteína p 16 en biopsias con diagnóstico de NIC I, positivas para Genoma de Papiloma Virus Humano. Instituto del Cáncer. SOLCA Cuenca-Ecuador. 2009-2010.

    OpenAIRE

    Murillo Bacilio, Magdali del Rocío; Ugalde Puyol, Jorge Edmundo; Palta González, Araceli Miroslava; Picón Coronel, María Gabriela

    2015-01-01

    Numerosos estudios mencionan que la sobreexpresión de la proteína p16, un marcador biológico que permite identificar lesiones preneoplásicas del epitelio exocervical, tendría una alta asociación con el Papiloma Virus Humano (HPV) de alto riesgo oncogénico. Es un estudio descriptivo correlacional cuyo objetivo fue establecer asociación de las Neoplasias Intraepiteliales Cervicales grado I (NIC I), HPV positivos, con la expresión del p16. Materiales, métodos y resultados: Es un estudio corre...

  7. Comparación entre las biopsias gástricas sin fijar 24 horas frente a la biopsia convencional para el diagnóstico de Helicobacter pylori en un hospital de referencia de Perú Comparison between gastric biopsies without fixation for 24 hours and conventional biopsy for the diagnosis of Helicobacter pylori in a reference hospital in Peru

    Directory of Open Access Journals (Sweden)

    César Tadeo Vela-Velásquez

    2011-03-01

    Full Text Available Objetivos. Comparar biopsias gástricas fijadas inmediatamente con formol al 10% frente a biopsias fijadas tras 24 horas en la detección de Helicobacter pylori (Hp en un hospital de referencia en Perú. Materiales y métodos. Se realizó un estudio de test diagnóstico sobre las biopsias gástricas de 72 pacientes que acudieron al Servicio de Gastroenterología del Hospital Essalud Alberto Sabogal en el Callao. Las muestras de cada paciente fueron repartidas en dos frascos de vidrio, una de ellas se fijó inmediatamente con formol al 10% y a la otra se fijó luego de 24 horas. Se procesaron ambos grupos de muestras con la técnica convencional de inclusión en parafina y coloración con hematoxilina-eosina. Resultados. Se evidenció Hp en 56,9% del grupo de biopsias fijadas inmediatamente y en el 79,2% del grupo de biopsias fijadas tras 24 horas, encontrándose diferencia estadística (pObjectives. To compare gastric biopsies immediately fixed with 10% formalin with biopsies fixed after 24 hours for the detection of Helicobacter pylori (Hp in a reference hospital in Peru. Materials and methods. A diagnostic test study on gastric biopsies from 72 patients attending the Gastroenterology service of hospital Essalud Alberto Sabogal in Callao was performed. Samples from each patient were divided into two glass jars, one of which was fixed immediately with 10% formalin and the other was fixed after 24 hours. Both groups of samples were processed with the conventional technique of paraffin embedding and staining with hematoxylin-eosin. Results. Hp was found in 56.9% of the group of biopsies which were inmediatly fixed and in 79.2% of the group of biopsies fixed after 24 hours, showing statistical difference (p <0.001. Conclusions. There is an increased frequency of diagnosis of Hp in the samples that were fixed after 24 hours, which may suggest that this would act as a biological culture for Hp, which would facilitate its diagnosis.

  8. Análisis del valor de la biopsia del ganglio centinela en el melanoma cutáneo

    Directory of Open Access Journals (Sweden)

    C. Carrasco-López

    2015-09-01

    Full Text Available El melanoma cutáneo es una neoplasia cuya incidencia va en aumento en nuestro medio. Presentamos un estudio sobre 1023 casos de esta patología recogidos a lo largo de 20 años, distribuidos en 2 grupos: grupo A tratados antes del 2000, y grupo B tratados después del 2000. Comparamos la supervivencia de ambos grupos en base al cambio de tratamiento por la introducción del estudio del ganglio centinela a partir del año 2000. No observamos diferencias significativas entre los 2 grupos en la supervivencia de los pacientes con melanoma a pesar de realizar tratamientos más conservadores. Por tanto, gracias a la biopsia de ganglio centinela, se pueden evitar un 75% de linfadenectomías electivas realizadas en este tipo de patología sin modificar los índices de supervivencia.

  9. Oncogenes E6-E7 de los Papilomavirus Humanos de alto riesgo detectados por PCR en Biopsias de pene incluidas en parafina

    OpenAIRE

    Guerrero, I; R Mejía; Velazco, R.; O Misad; M Pow-Sang

    1999-01-01

    La alta prevalencia del papilomavirus humano (PVH), referida a nivel mundial, en lesiones genitales de ambos sexos, el rol del varón como reservorio pasivo del virus, y el incremento de la mortalidad por cáncer genital en la mujer en nuestro país, motiva la detección y correlación de los oncogenes de los PVH de alto riesgo con la neoplasia de pene. Informamos de diez casos de biopsias de carcinoma escamoso de pene, incluidos en parafina, los cuales fueron investigados para la presencia de los...

  10. Utilidad de la biopsia transbronquial en el diagnostico de enfermedades pulmonares en pacientes VIH/SIDA

    Directory of Open Access Journals (Sweden)

    Carmen Elena Fuenmayor

    2014-04-01

    Full Text Available La biopsia transbronquial es una herramienta útil en el diagnóstico de un grupo heterogéneo de enfermedades pulmonares. El objetivo del presente estudio fue determinar la etiología de los procesos pulmonares más frecuentes en el grupo de pacientes VIH/SIDA controlados en el Instituto Autónomo Hospital Universitario de los Andes durante el periodo febrero a septiembre del 2009. Se realizó un estudio observacional, analítico y descriptivo con enfoque epidemiológico, clínico y anatomopatológico en un grupo de 39 pacientes portadores de virus de Inmunodeficiencia Humana. De estos solamente 36 cumplieron los criterios de inclusión para esta investigación. Se hicieron análisis sanguíneo, perfil inmunológico, estudios imagenológicos, lavado bronco-alveolar, cepillado bronquial y biopsia transbronquial. Los cortes histológicos mostraron respuesta inflamatoria en diferentes fases de evolución, daño alveolar difuso y edema intraalveolar. Se realizó el diagnóstico de un grupo de enfermedades oportunistas tales como: neumocistosis, Histoplasmosis, Candidiasis y lesiones probablemente debidas a virus Herpes y Citomegalovirus. Se destaca la participación de más de un germen. Además hubo vasculitis, trombos, áreas de infarto, fibrosis intersticial y hallazgos sugestivos de Hipertensión Pulmonar. Uno de los pacientes presento neoplasia maligna epitelial indiferenciada. El empleo de esta técnica permitió evaluar la presencia de infecciones oportunistas y neoplasias infrecuentes, así como los hallazgos sugestivos de Hipertensión pulmonar. Se avala su utilización ante la necesidad de realizar un diagnóstico etiológico de certeza y establecer así la terapéutica adecuada. Utility transbronchial biopsy in the diagnosis ofpulmonary disease in patients HIV/AIDS Abstract Transbronchial biopsy is a useful tool in the diagnosis of a heterogeneous group of lung diseases. The aim of this study was to determine the etiology of pulmonary

  11. Transrectal Drainage of Deep Pelvic Abscesses Using a Combined Transrectal Sonographic and Fluoroscopic Guidance

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Kyung Soon; Lee, Eun Jung; Ko, Ji Ho; Joh, Young Duk [Gospel Hospital, Kosin University College of Medicine, Busan (Korea, Republic of); Jung, Gyoo Sik [Ulsan Hospital, Ulsan (Korea, Republic of)

    2005-09-15

    To evaluate the feasibility and clinical efficacy of transrectal drainage of a deep pelvic abscess using combined transrectal sonographic and fluoroscopic guidance. From March 1995 and August 2004, 17 patients (9 men; 8 women; mean age, 39 years) suffering from pelvic pain, fever and leukocytosis were enrolled in this retrospective study. Ultrasound (US) or computed tomography (CT), which was obtained prior to the procedure, showed pelvic fluid collections that were deemed unapproachable by the percutaneous trans abdominal routes. Transrectal drainage of the pelvic abscess was performed under combined transrectal sonographic and fluoroscopic guidance. The causes of the deep pelvic abscess were postoperative complications (n=7), complications associated with radiation (n=3) and chemotherapy (n=1) as well as unknown causes (n=6). A 7.5-MHz end-firing transrectal US probe with a needle biopsy guide attachment was advanced into the rectum. Once the abscess was identified, a needle was advanced via the biopsy guide and the abscess was punctured. Under US guidance, either a 0.018'or 0.035' guide wire was passed through the needle in the abscess. Under fluoroscopic guidance, the tract was dilated to the appropriate diameter with sequential fascial dilators, and a catheter was placed over the guide wire within the abscess. Clinical success of drainage was determined by a combination closure of the cavity on the follow up images and diminished leukocytosis. The technical and clinical success rate, complications, and patient's discomfort were analyzed. Drainage was technically successful in all patients and there were no serious complications. Surgery was eventually performed in two cases due to fistular formation with the rectum and leakage of the anastomosis site. The procedure was well tolerated in all but one patient who complained of discomfort while the catheter was inserted . The catheter did not interfere with defecation and there was no incidence of

  12. Role of transrectal ultrasonography in evaluating the cause of azoospermia

    Energy Technology Data Exchange (ETDEWEB)

    Yassa, N.A.; Keesara, S. [Univ. of Southern California, Dept. of Radiology, Los Angeles, California (United States)

    2001-08-01

    To assess the role of transrectal ultrasonography in the investigation of azoospermia, a significant cause of infertility. Over a 2-year period, 35 patients with azoospermia underwent an infertility workup, which included transrectal ultrasonography. Sonograms of 10 of the 35 patients were normal; 8 patients had enlarged seminal vesicles containing cysts, 6 had ejaculatory duct dilation, 5 had seminal vesicle calcification, 3 had seminal vesicle atrophy-hypoplasia and 3 patients had midline prostatic cysts. Transrectal sonography is a useful modality to evaluate seminal duct abnormalities, some of which may cause azoospermia. (author)

  13. TRANSRECTAL ULTRASOUND GUIDED PROSTATIC NERVE BLOCKADE FOR PAIN CONTROL DURING TRANSRECTAL PROSTATE BIOPSY

    Institute of Scientific and Technical Information of China (English)

    YANG Liu-ping; DENG Jun-hong; ZHONG Hong; HU Jian-bo; WEI Hong-ai; WANG Liang-sheng

    2005-01-01

    Objective: To assess the effect of transrectal ultrasound guided prostatic nerve blockade on the discomfort associated with systematic biopsy of the prostate. Methods: 73 patients receiving systematic 13 cores biopsy of the prostate were randomized into two groups. Group A(37 cases) received an injection of 5 ml 1% lidocaine into the prostatic neurovascular bundles on each side at the base of the prostate under ultrasound guidance and group B(36 cases) received 5 ml saline injection (0.9% sodium chloride) at the same site. Pain during biopsy was assessed by using a 10-point linear visual analog score (VAS) immediately after the biopsy. Results: The mean pain scores during transrectal prostate biopsy were significantly lower in group A than group B(1.1±0.6 versus 5.9±3.1, t=4.81, P<0.01). During this study no patient in either group had any adverse effect from the injection. Conclusion: Transcrectal ultrasound guided prostatic nerve blockade is a safe and efficacious method for providing satisfactory anesthesia in transrectal prostate biopsy. We recommend its routine administration in all patients during this procedure.

  14. Biopsy needle detection in transrectal ultrasound.

    Science.gov (United States)

    Ayvaci, Alper; Yan, Pingkun; Xu, Sheng; Soatto, Stefano; Kruecker, Jochen

    2011-01-01

    Using the fusion of pre-operative MRI and real time intra-procedural transrectal ultrasound (TRUS) to guide prostate biopsy has been shown as a very promising approach to yield better clinical outcome than the routinely performed TRUS only guided biopsy. In several situations of the MRI/TRUS fusion guided biopsy, it is important to know the exact location of the deployed biopsy needle, which is imaged in the TRUS video. In this paper, we present a method to automatically detect and segment the biopsy needle in TRUS. To achieve this goal, we propose to combine information from multiple resources, including ultrasound probe stability, TRUS video background model, and the prior knowledge of needle orientation and position. The proposed algorithm was tested on TRUS video sequences which have in total more than 25,000 frames. The needle deployments were successfully detected and segmented in the sequences with high accuracy and low false-positive detection rate.

  15. Local staging of prostate cancer with transrectal ultrasound

    DEFF Research Database (Denmark)

    Lorentzen, T; Nerstrom, H; Iversen, P;

    1992-01-01

    A literature review was undertaken to investigate whether transrectal ultrasound can predict the local stage of prostate cancer. Twelve papers were found which correlated ultrasound findings with surgical findings and another paper reported on strategic staging biopsies guided by transrectal...... ultrasound. Eleven of these papers reported on ultrasound findings in patients in whom digital rectal examination had defined localized disease. One paper compared ultrasound findings and digital rectal findings. One paper indicated that transrectal ultrasound, though not suited to patients with clinically...... localized disease defined by digital rectal examination, may be superior as the initial staging tool. We conclude that transrectal ultrasound has too low a specificity to upgrade the diagnostic results of digital rectal examination, but that it may be more useful as the primary staging tool and for guidance...

  16. Life-threatening meningitis resulting from transrectal prostate biopsy

    Institute of Scientific and Technical Information of China (English)

    Zhou-Jun Shen; Shan-Wen Chen; Hua Wang; Xie-Lai Zhou; Ju-Ping Zhao

    2005-01-01

    After antibiotic prophylaxis with metronidazole and levofloxacin, a transrectal sextant biopsy was performed under the guide of transrectal ultrasonography (TRUS) for a 75-year-old suspicious patient with prostate adenocarcinoma.Although antibiotics were also given after this procedure, the patient still developed fever, anxious, agrypnia and headache. Blood cultures remained negative. Lumbar puncture was performed and was consistent with Escherichia coli bacterial meningitis.

  17. Diagnosis of Helicobacter pylori infection using urease rapid test in patients with bleeding duodenal ulcer: influence of endoscopic signs and simultaneous corporal and antral biopsies Diagnóstico de la infección por Helicobacter pylori mediante el test rápido de la ureasa en pacientes con hemorragia por úlcera duodenal: influencia de los signos endoscópicos de sangrado y de la obtención simultánea de biopsias de cuerpo y antro gástrico

    Directory of Open Access Journals (Sweden)

    M. Castro Fernández

    2004-09-01

    patients with combined antral and fundic biopsies. In group A, urease test was positive in 90.5% of patients; in group B, it was positive in 89.5% of patients, and in group C, the test turned positive in 75.4% of patients. Statistical differences were only reached when patients in group C were compared to patients in groups A and B together (p = 0.037. Conclusions: 1. The presence of either blood in the stomach or recent bleeding endoscopic signs appeared not to be the conditioning factor for the decreased sensitivity of urease test among patients with bleeding duodenal ulcer. 2. The decreased sensitivity of this test in patients with upper gastrointestinal bleeding is more evident during the resolution stage, and it does not seem to occur because of H. pylori migration from the antrum to the corporal gastric region.Introducción: la sensibilidad de los métodos diagnósticos invasivos de infección por H. pylori, especialmente el test rápido de la ureasa, disminuye en los casos de úlcera gastro-duodenal y hemorragia digestiva. Objetivos: valorar la influencia de la presencia de sangre en estómago o de signos endoscópicos de sangrado en la sensibilidad del test rápido de la ureasa en pacientes con hemorragia por úlcera duodenal, así como la influencia de la obtención de biopsias de cuerpo y antro gástrico. Pacientes y métodos: incluimos 120 pacientes, 85 varones y 35 mujeres, con edad media de 62 (18-88 años, con hemorragia por úlcera duodenal y diagnóstico endoscópico en las primeras 24 horas del ingreso. Ningún paciente había consumido antiinflamatorios no esteroideos, inhibidores de la bomba de protones o antibióticos en las dos semanas previas a la hemorragia digestiva, ni había recibido tratamiento frente a H. pylori. En este grupo seleccionado de pacientes admitimos una tasa de infección de prácticamente el 100%. Investigamos la infección por H. pylori mediante biopsias de antro (69 casos o de cuerpo y antro (51 casos gástricos para test de

  18. Condiloma acuminado : Biopsia de un caso clínico

    OpenAIRE

    Santángelo, Georgina; Ricciardi, A.; Bogo, P.; Prada, G; Cacciola, S.; Celis, Z.; Di Franco, P.; Teixeira Pocas, M.; Lunaschi, A.

    2015-01-01

    Se reporta un caso clínico de un paciente masculino, de 12 años de edad que asistió al área clínica de la Cátedra de Cirugía A de la Facultad de Odontología de la UNLP. Al examen intrabucal, se observaron múltiples lesiones en forma de placas o pápulas, sésiles, con superficie en empedrado, del mismo color que el resto de la mucosa, no queratinizadas, localizadas a lo largo de toda la mucosa del labio inferior y algunas solitarias en la mucosa del labio superior. Se tomó una muestra de la les...

  19. Biopsia de la arteria temporal: revisión de indicaciones y técnica quirúrgica para cirujanos plásticos Temporal artery biopsy: review of indications and surgical technique for plastic surgeons

    Directory of Open Access Journals (Sweden)

    A. Rodríguez Lorenzo

    2007-06-01

    Full Text Available La arteritis de células gigantes (ACG es una vasculitis que presenta complicaciones graves si no es diagnosticada y tratada precozmente con corticoides a altas dosis. La biopsia de la arteria temporal (BAT es la técnica diagnóstica estandarizada utilizada para confirmar la enfermedad. Se trata de una técnica sencilla y con poca morbilidad. No obstante, en la actualidad existe una controversia sobre su indicación en pacientes con sospecha clínica de arteritis sin síntomas craneales debido a la baja tasa de positividad de la biopsia. Presentamos en este trabajo una serie de 28 pacientes en los que se realizaron 30 BAT con el objetivo de revisar las indicaciones y describir la técnica quirúrgica utilizada.Giant cell arteritis is a vasculitis that presents serious complications if it is not diagnosed and treated prematurely with corticosteroids to high dose. The temporal artery biopsy is the gold estandar technique of diagnosis used to confirm the disease. It is a simple technique with little morbidity. Nevertheless, currently there is a controversy on its indication in patients with clinical suspicion of arteritis without craneal symptoms because of the downward rate of positiveness of the biopsy. We present in this work a serie of 28 patients in which 30 biopsies were carried out with the objective to review the indications and to describe the surgical technique utilized.

  20. Hepatotoxicidad inducida por azatioprina en paciente con enfermedad de Crohn

    Directory of Open Access Journals (Sweden)

    D. Ruiz-Clavijo

    2013-08-01

    Full Text Available Los inmunosupresores se encuentran entre los grupos farmacológicos con mayor potencial teórico de inducir reacciones adversas, entre ellas las hepáticas. Presentamos el caso de un paciente de 35 años con enfermedad de Crohn en tratamiento con azatioprina por corticodependencia al que se le diagnosticó tras realización de una biopsia hepática de hiperplasia nodular regenerativa secundaria a este tratamiento.

  1. Criptococosis gingival en un paciente con SIDA

    OpenAIRE

    Delgado-Azañero, Wilson A.; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,; Meneses Rivadeneyra, Leopoldo; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,; Gotuzzo Herencia, Eduardo; Instituto de Medicina Tropical “Alexander von Humboldt”. Universidad Peruana Cayetano Heredia. Lima,; Bustamante, Beatriz; Instituto de Medicina Tropical “Alexander von Humboldt”. Universidad Peruana Cayetano Heredia. Lima,

    2014-01-01

    La criptococosis es una infección micótica que afecta a personas con o sin inmunosupresión. Sepresenta principalmente como una infección pulmonar crónica. La mayoría de casos enmucosa oral han sido reportados en pacientes con SIDA que cursaban con la forma diseminadade la infección. Se presenta un paciente varón de 36 años con SIDA, cuyo diagnóstico decriptococosis se estableció por biopsias de las encías. El cuadro oral se caracterizó poragrandamientos gingivales del sector ántero superior e...

  2. Avaliações ultra-sonográfica, macroscópica e histológica da biopsia testicular em ovinos

    OpenAIRE

    Sartori R; Prestes N.C.; Canavessi A.M.O.; Kempinas W.G.; Rosa G.J.M.

    2002-01-01

    Devido ao fato da biopsia testicular poder acarretar hemorragia, inflamação, degeneração, aderência e fibrose, especialmente com as técnicas incisionais ou abertas, este trabalho avaliou a aplicabilidade de uma técnica menos invasiva (biopsia com agulha Tru-Cut) em ovinos na obtenção de material para histologia e acompanhou as lesões testiculares posteriores. Trinta carneiros foram igualmente divididos em três grupos: 1) controle, animais não submetidos à biopsia; 2) submetidos à biopsia + co...

  3. Sonablate-500TM Transrectal High-intensity Focused Ultrasound (HIFU) for Benign Prostatic Hyperplasia Patients

    Institute of Scientific and Technical Information of China (English)

    L(U) Jun; HU Weilie; WANG Wei; ZHANG Yuanfeng; CHEN Zhaoyang; YE Zhangqun

    2007-01-01

    To evaluate the safety and efficacy of transrectal high-intensity focused ultrasound (HIFU) in the treatment of benign prostatic hyperplasia (BPH), serial studies were conducted in 150 BPH pa- tients before and 30 min, 1, 2, 6 and 12 month(s) after Sonablate-500TM HIFU treatment. A sili- con-coated indwelling 16F latex catheter was placed during the determination of the therapy zone. Preoperative and postoperative evaluations were made by using the international prostate symptom score (IPSS), quality of life (QOL), uroflowmetric findings and transrectal ultrasound, and incidence of complications. The cystourethrography was done in 23 patients within 1 year postoperatively. The results showed that after HIFU treatment, IPSS and QOL scores were significantly decreased at 1, 2, 6 and 12 month(s) (P<0.01). Maximum urine flow rate (6.0 to 17.2 mL/s, P<0.01), PVR (75.0 to 30.3,P<0.01) and prostatic volume (65.0 to 38.1 mL, P<0.05) were significantly improved 12 months after the operation. Recurrent urinary retention (n=2) and urethrorectal fistula (n=1) occurred at the 15th postoperative day. The duration of the HIFU prostate ablation was 25-90 rain. The mean time for an indwelling catheter was 3-19 days. These data demonstrate that treatment of BPH with Sonab- late-500TM HIFU is safe and effective.

  4. Transperineal seed-implantation guided by biplanar transrectal ultrasound

    DEFF Research Database (Denmark)

    Holm, Hans Henrik; Torp-Pedersen, S; Myschetzky, P

    1990-01-01

    A new method for precise transperineal placement of therapeutic sources in prostatic cancer is described. The method is a modification of the technique described in 1983 by Holm and coworkers. Insertion of needles is monitored by transverse as well as longitudinal transrectal ultrasound.......A new method for precise transperineal placement of therapeutic sources in prostatic cancer is described. The method is a modification of the technique described in 1983 by Holm and coworkers. Insertion of needles is monitored by transverse as well as longitudinal transrectal ultrasound....

  5. Resultados de biopsia guiada por tomografía axial computarizada en el síndrome de destrucción vertebral, evaluados en dos instituciones distintas

    Directory of Open Access Journals (Sweden)

    Barón Zarate-Kalfopulos

    2013-01-01

    Full Text Available OBJETIVO: Comparar resultados de biopsias vertebrales guiadas por tomografía axial computarizada, reportados por dos servicios de Anatomía Patológica distintos en pacientes con síndrome de destrucción vertebral para confirmar confiabilidad y utilidad en el diagnóstico. MÉTODOS: Se obtuvieron muestras de tejido de 21 pacientes en el periodo comprendido del 1 de marzo al 15 de julio del 2011 con el diagnóstico del síndrome de destrucción vertebral y a quienes se les realizó biopsia guiada por tomografía axial computarizada. Las muestras se enviaron en forma cegada a dos servicios de patología distintos. Los resultados fueron analizados con el método de comparación de dos proporciones. RESULTADOS: 14 pacientes fueron del género masculino (67% y 7 del femenino (23%, edades de 28-82, con afección principalmente lumbar (48% y torácica (38%; afectados en una vértebra en 62%, en dos en un 33% y en 3 o más niveles en 5%. Las vértebras más afectadas fueron L1, L2 y L3 (12/30 [40%], T4 (3/30 [10%] y T9 (3/30 [10%]. Los resultados se agruparon en categorías: 1. Osteomielitis (9/21 [43%], 2. Tumores (7/21 [33%], 3. Metástasis (3/21 [14%], 4. Tejido normal (2/21 [10%], 5. Inflamación (0/21 [0%], 6. Muestra inadecuada (0/21 [0%], 7. Mal de Pott (0/21 [0%]. CONCLUSIONES: De acuerdo a los valores de Z obtenidos mediante la prueba de comparación de dos proporciones no se encontró diferencia significativa entre los resultados reportados por dos los dos servicios de patología en el síndrome estudiado, determinándose que esta parte del proceso es confiable y útil en un 90%.

  6. Manual transrectal palpations performed by veterinary students in cows: a Surrey - Palpaciones transrectales realizadas por estudiantes de veterinaria en las vacas: una encuesta

    OpenAIRE

    João Simões

    2012-01-01

    AbstractVeterinary education of novice veterinary students in bovine reproduction field, like rectum palpation training, represent some handicaps mainly related with animal welfare.ResumenLa educación veterinaria de estudiantes de veterinaria en el campo de la reproducción bovina, en el caso del entrenamiento mediante la palpación transrectal, tiene algunas desventajas, principalmente relacionadas con el bienestar animal.

  7. Manual transrectal palpations performed by veterinary students in cows: a Surrey - Palpaciones transrectales realizadas por estudiantes de veterinaria en las vacas: una encuesta

    Directory of Open Access Journals (Sweden)

    João Simões

    2012-03-01

    Full Text Available AbstractVeterinary education of novice veterinary students in bovine reproduction field, like rectum palpation training, represent some handicaps mainly related with animal welfare.ResumenLa educación veterinaria de estudiantes de veterinaria en el campo de la reproducción bovina, en el caso del entrenamiento mediante la palpación transrectal, tiene algunas desventajas, principalmente relacionadas con el bienestar animal.

  8. Antibiotic prophylaxis for transrectal prostate biopsy-a new strategy

    DEFF Research Database (Denmark)

    Antsupova, Valeria; Nørgaard, Nis; Bisbjerg, Rasmus

    2014-01-01

    BACKGROUND: Fluoroquinolones are extensively used as prophylaxis for transrectal ultrasound-guided biopsy of the prostate (TRUBP). Emerging fluoroquinolone resistance and selection of multiresistant organisms warrant new prophylactic strategies. Pivmecillinam and amoxicillin/clavulanic acid have...... pivmecillinam and amoxicillin/clavulanic acid was used (5.9%). CONCLUSIONS: The combination of pivmecillinam and amoxicillin/clavulanic acid is an attractive prophylaxis for TRUBP from a clinical, bacteriological and ecological point of view as compared with ciprofloxacin....

  9. Usefulness of jejunal biopsy in the study of intestinal malabsorption in the elderly Utilidad de la biopsia yeyunal en el estudio de la malabsorción intestinal en el anciano

    Directory of Open Access Journals (Sweden)

    B. Lobo

    2004-04-01

    clave en el estudio de la malabsorción intestinal es la biopsia yeyunal, cuya utilidad, eficacia o complicaciones, son poco conocidas en el grupo de población de edad avanzada. Objetivo: determinar la utilidad de la biopsia yeyunal con la cápsula de Watson en el anciano. Pacientes: pacientes de edad superior a los 65 años, remitidos para biopsia yeyunal desde 1996 a 2001 por sospecha de malabsorción intestinal. Resultados: se han incluido 47 pacientes. La biopsia obtuvo muestra útil para estudio histológico en 42 casos, obteniendo muestra en un segundo intento en 3 de los 5 fracasos iniciales. La histología demostró atrofia vellositaria parcial en 10 casos (22,2%, atrofia vellositaria completa en 5 (11,1%, linfocitosis intraepitelial en 5 (11,1%, y casos aislados de linfangiectasia intestinal, amiloidosis, yeyunitis inespecífica y enfermedad de Whipple. La histología fue normal en 19 casos (42%. El diagnóstico definitivo fue enfermedad celíaca en 14 pacientes, sobrecrecimiento bacteriano en 3, yeyunitis en 3, enfermedad de Whipple en 1, linfangiectasia en 1, gastritis atrófica en 3, amiloidosis en 1 (asociada a sobrecrecimiento bacteriano, y colitis isquémica en 1. La biopsia yeyunal fue esencial para el diagnóstico en 20 pacientes. No se registró perforación o hemorragia en ningún paciente. Conclusión: en el estudio de la malabsorción intestinal del anciano, la biopsia yeyunal es un método diagnóstico útil y seguro para identificar la causa de la malabsorción.

  10. DETECCIÓN DE BACILOS ÁCIDO ALCOHOL RESISTENTES EN BIOPSIAS EMBEBIDAS EN PARAFINA EN CASOS DE INFLAMACIÓN GRANULOMATOSA CRÓNICA.

    Directory of Open Access Journals (Sweden)

    JAVIER ANDRÉS BUSTAMANTE

    2010-01-01

    Full Text Available La detección de bacilos ácido alcohol resistentes (BAAR en frotis resulta un aporte significativo al diagnóstico y tratamiento de individuos con inflamación granulomatosa crónica (IGC. Con el objetivo de evaluar la presencia de BAAR en diferentes tejidos de pacientes con IGC demostrada y comparar la frecuencia de los extendidos positivos para BAAR con el grado de formación de granulomas y necrosis, se diseño un estudio retrospectivo, en el que se seleccionaron 57 bloques embebidos en parafina que contenían biopsias de pleura, pulmón, pericardio, ganglio linfático y lóbulo cerebral, correspondientes a 30 pacientes (63,3% hombres, mayores de 18 años, con IGC demostrada y remitidos al departamento de patología del Hospital Universitario del Valle entre el 2002-2008. A cada muestra se le realizaron tres cortes y se sometieron a tinciones de H/E, Zielh Neelsen y Auramina. La detección de BAAR en frotis fue similar para ambas tinciones especiales en pacientes con IGC necrotizante, reflejando una excelente concordancia en el diagnóstico (kappa=0,89, IC95%[0,68-1,0]. Sin embargo, la tinción con Auramina fue superior a la tinción Ziehl Neelsen para la detección de BAAR en pacientes con IGC no necrotizante (kappa=0,65, IC95%[0,23-1,0]. No se encontraron diferencias significativas entre la presencia de BAAR y el tipo de inflamacion, sexo y localización anatómica comprometida. En general, fue buena la concordancia entre los métodos histológicos empleados. Además, se hizo evidente la importancia de implementar el uso de técnicas moleculares mínimamente afectadas por el escaso número de bacilos presentes en las muestras, que finalmente ayudan en el reconocimiento del microorganismo.

  11. Repeat prostate biopsy accuracy: simulator-based comparison of two- and three-dimensional transrectal US modalities.

    Science.gov (United States)

    Cool, Derek W; Connolly, Michael J; Sherebrin, Shi; Eagleson, Roy; Izawa, Jonathan I; Amann, Justin; Romagnoli, Cesare; Romano, Walter M; Fenster, Aaron

    2010-02-01

    To compare the accuracy of biopsy with two-dimensional (2D) transrectal ultrasonography (US) with that of biopsy with conventional three-dimensional (3D) transrectal US and biopsy with guided 3D transrectal US in the guidance of repeat prostate biopsy procedures in a prostate biopsy simulator. The institutional review board approved this retrospective study. Five residents and five experts performed repeat biopsies with a biopsy simulator that contained the transrectal US prostate images of 10 patients who had undergone biopsy. Simulated repeat biopsies were performed with 2D transrectal US, conventional 3D transrectal US, and guided 3D transrectal US (an extension of 3D transrectal US that enables active display of biopsy targets). The modalities were compared on the basis of time per biopsy and how accurately simulated repeat biopsies could be guided to specific targets. The probability for successful biopsy of a repeat target was calculated for each modality. Guided 3D transrectal US was significantly (P < .01) more accurate for simulated biopsy of repeat targets than was 2D or 3D transrectal US, with a biopsy accuracy of 0.86 mm +/- 0.47 (standard deviation), 3.68 mm +/- 2.60, and 3.60 mm +/- 2.57, respectively. Experts had a 70% probability of sampling a prior biopsy target volume of 0.5 cm(3) with 2D transrectal US; however, the probability approached 100% with guided 3D transrectal US. Biopsy accuracy was not significantly different between experts and residents for any modality; however, experts were significantly (P < .05) faster than residents with each modality. Repeat biopsy of the prostate with 2D transrectal US has limited accuracy. Compared with 2D transrectal US, the biopsy accuracy of both experts and residents improved with guided 3D transrectal US but did not improve with conventional 3D transrectal US.

  12. Biopsia Hepática Percutânea na Criança - Experiência de 10 anos

    OpenAIRE

    Lopes, Ana Isabel; Costa, Adília

    2014-01-01

    A biopsia hepática percutânea (BHP) na criança é um meio de diagnóstico essencial na investigação da doença hepática, mas que envolve risco de morbilidade e mortalidade não negligenciáveis.Novas modalidades inerentes ao procedimento têm vindo a ser propostas, designadamente quanto à própria técnica e quanto ao regime de vigilância pós-biopsia. Apresenta-se a experiência pessoal de BHP no período de 10 anos (1994 - 2003) referente a casuística não associada a transplante hepático (80 biópsias ...

  13. Transrectal Near-Infrared Optical Tomography for Prostate Imaging

    Science.gov (United States)

    2011-03-01

    2009. CA Cancer J Clin. 2009;59:225-249. 2. Hodge KK, McNeal JE, Stamey TA. Ultrasound guided transrectal core biopsies of the palpably abnormal...near-infrared spectroscopy: pilot results in the breast," Radiology 218, 261-266 (2001). [4] Tara Yates, Jeremy C Hebden, Adam Gibson, Nick ...digital rectal examination as screening tests for prostate carcinoma,” J Am Board Fam Pract.; 16(2):95- 101 (2003). 3. Hodge KK, McNeal JE, Stamey TA

  14. Optimizing prostate biopsy for repeat transrectal prostate biopsies patients

    Institute of Scientific and Technical Information of China (English)

    Xiaojun Deng; Jianwei Cao; Feng Liu; Weifeng Wang; Jidong Hao; Jiansheng Wan; Hui Liu

    2014-01-01

    Objective:Diagnosis of patients with negative prostate biopsy and persistent suspicion of prostate cancer re-mains a serious problem. In this study, we investigated the application of optimizing prostate biopsy for patients who need repeat prostate biopsy. Methods:In this prospective, non-randomized phase-I clinical trial, the prostate cancer detection rate of initial detection scheme was compared with optimizing prostate biopsy scheme. The number of punctures of initial detection scheme was the same as that of optimizing prostate biopsy scheme. The puncture direction of optimizing prostate biopsy was a 45° angle to the sagittal plane from front, middle, and back. The two cores from each lateral lobe were horizontal y inwardly inclined 45°. Results:A total of 45 patients with initial negative biopsy for cancer were received the optimizing prostate biopsy scheme. The cancer detection rate was 17.8%(8/45), and prostate intraepithelial neoplasm (PIN) was 6.7%(3/45). The pa-tients receiving repeat transrectal prostate biopsies were pathological y diagnosed as lower Gleason grade prostate cancers. Conclusion:The cancer detection rate of repeat biopsy prostate cancer is lower than that of initial biopsy. Our study showed that the optimizing prostate biopsy is important to improve the detection rate of repeat transrectal prostate biopsies patients.

  15. Application of reinforcement learning for segmentation of transrectal ultrasound images

    Directory of Open Access Journals (Sweden)

    Tizhoosh Hamid R

    2008-04-01

    Full Text Available Abstract Background Among different medical image modalities, ultrasound imaging has a very widespread clinical use. But, due to some factors, such as poor image contrast, noise and missing or diffuse boundaries, the ultrasound images are inherently difficult to segment. An important application is estimation of the location and volume of the prostate in transrectal ultrasound (TRUS images. For this purpose, manual segmentation is a tedious and time consuming procedure. Methods We introduce a new method for the segmentation of the prostate in transrectal ultrasound images, using a reinforcement learning scheme. This algorithm is used to find the appropriate local values for sub-images and to extract the prostate. It contains an offline stage, where the reinforcement learning agent uses some images and manually segmented versions of these images to learn from. The reinforcement agent is provided with reward/punishment, determined objectively to explore/exploit the solution space. After this stage, the agent has acquired knowledge stored in the Q-matrix. The agent can then use this knowledge for new input images to extract a coarse version of the prostate. Results We have carried out experiments to segment TRUS images. The results demonstrate the potential of this approach in the field of medical image segmentation. Conclusion By using the proposed method, we can find the appropriate local values and segment the prostate. This approach can be used for segmentation tasks containing one object of interest. To improve this prototype, more investigations are needed.

  16. [Calcifications of the prostate: a transrectal echographic study].

    Science.gov (United States)

    Bock, E; Calugi, V; Stolfi, V; Rossi, P; D'Ascenzo, R; Solivetti, F M

    1989-05-01

    Prostatic lithiasis is a well know phenomenon. It has little clinical significance and is not easily shown by conventional radiography, which has poor sensitivity and specificity. The authors have studied 612 patients with both suprapubic and transrectal US in order to 1) assess US sensitivity and specificity and 2) report the frequency, spatial distribution, number and features of prostatic calcifications with special emphasis on differential diagnosis between prostatic neoplasms and chronic prostatitis. The authors have also studied the relationship between morphology and symptoms and the results agree with those reported in the scanty literature. The authors conclude that the parameters studied are directly related to age, except for a younger group with clear evidence of genital inflammation. The authors emphasize the impossibility to correlate morphology of prostatic calcifications with pathologic conditions: there are no specific symptoms clearly connected with calcification even though the inflammation is often associated with calcifications.

  17. Transrectal ultrasonography of anorectal disease: advantages and disadvantages

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Min Ju [Dept. of Radiology, Korea University Anam Hospital, Korea University College of Medicine, Seoul (Korea, Republic of)

    2015-01-15

    Transrectal ultrasonography (TRUS) has been widely accepted as a popular imaging modality for Epub ahead of print evaluating the lower rectum, anal sphincters, and pelvic floor in patients with various anorectal diseases. It provides excellent visualization of the layers of the rectal wall and of the anatomy of the anal canal. TRUS is an accurate tool for the staging of primary rectal cancer, especially for early stages. Although magnetic resonance imaging is a modality complementary to TRUS with advantages for evaluating the mesorectum, external sphincter, and deep pelvic inflammation, three-dimensional ultrasonography improves the detection and characterization of perianal fistulas and therefore plays a crucial role in optimal treatment planning. The operator should be familiar with the anatomy of the rectum and pelvic structures relevant to the preoperative evaluation of rectal cancer and other anal canal diseases, and should have technical proficiency in the use of TRUS combined with an awareness of its limitations compared to magnetic resonance imaging.

  18. Ultrasound-guided transrectal extended prostate biopsy: a prospective study

    Institute of Scientific and Technical Information of China (English)

    Mohammed Ahmed Al-Ghazo; Ibrahim Fathi Ghalayini; Ismail Ibrahim Matalka

    2005-01-01

    Aim: To evaluate the diagnostic value of the 10 systematic transrectal ultrasound-guided (TRUS) prostate biopsy compared with the sextant biopsy technique for patients with suspected prostate cancer. Methods: One hundred and fifty-two patients with suspected prostate cancer were included in the study. Patients were entered in the study because they presented with high levels of prostate specific antigen (PSA) (over 4 ng/mL) and/or had undergone an abnormal digital rectal examination (DRE). In addition to sextant prostate biopsy cores, four more biopsies were obtained from the lateral peripheral zone with additional cores from each suspicious area revealed by transrectal ultrasound. Sextant, lateral peripheral zone and suspicious area biopsy cores were submitted separately to the pathological department. Results: Cancer detection rates were 27.6% (42/152) and 19.7% (30/152) for the 10-core and sextant core biopsy protocols, respectively. Adding the lateral peripheral zone (PZ) to the sextant prostate biopsy showed a 28.6% (12/42) increase in the cancer detection rate in patients with positive prostate cancer (P < 0.01).The cancer detection rate in patients who presented with elevated PSA was 29.3% (34/116). When serum PSA was 4-10 ng/mL TRUS-guided biopsy detected cancer in 20.6%, while the detection rate was 32.4% and 47.0% when serum PSA was 10-20 ng/mL and above 20 ng/mL, respectively. Conclusion: The 10 systematic TRUS-guided prostate biopsy improves the detection rate of prostate cancer by 28.6% when compared with the sextant biopsy technique alone, without increase in the morbidity. We therefore recommend the 10-core biopsy protocol to be the preferred method for early detection of prostate cancer.

  19. The diagnostic value of transrectal ultrasonographic features in prostate cancer

    Institute of Scientific and Technical Information of China (English)

    Xiaoli Zou; Guang Yang; Hui Wang

    2012-01-01

    Objective: The aim of the study was to detect the valuable ultrasonographic features in diagnosing prostate cancer.Methods: The patients who underwent transrectal ultrasound in the period from May 2005 to October 2009 at the 1st Affiliated Hospital of Dalian Medical University, China, were included, with needle biopsy diagnosis for patients with the prostate cancer and prostatic hyperplasia.Seventy-four cases of prostate cancer were diagnosed as adenocarcinoma, compared with 51 cases diagnosed as prostatic hyperplasia.Retrospective analysis of patients with transrectal ultrasound were done, comparing the difference between the two groups in the echo level (hypoechogenic), outlines (ill-defined margin), posterior acoustic attenuation, periphery halo, microcalcification incidence, the blood supply level, peak systolic velocity (Vs) and resistance index (RI).Results: The ratios of hypoechogenic lesions in the prostate cancer group and prostatic hyperplasia group were 56.76% and 35.90%, respectively (P 0.05).Vs of the two groups were (44.00 ± 15.30) cm/s and (17.32 ± 4.65) cm/s, respectively (P < 0.05).RI of the two groups were 0.76 ± 0.10, and 0.51 ± 0.03 respectively (P < 0.05).The significant correlation was designated in the blood supply level between the prostate cancer group and prostatic hyperplasia group (r = -0.388, P < 0.01).Higher revascularization grade was seen in the prostate cancer group compared to benign prostatic hyperplasia group.Conclusion: (1) The significant roles for diagnosing prostate cancer are hypoechogenic, irregular outlines, spiculation, microcalcification, high revascularization grade, posterior acoustic attenuation, high Vs and high RI.(2) It could not help in diagnosing prostate cancer with ultrasonographic periphery halo or not.

  20. Diagnóstico inicial de Linfoma de Hodgkin en biopsias de médula ósea

    OpenAIRE

    Kitagawa, R. B.; Martín, C. A.

    2016-01-01

    El Linfoma de Hodgkin (LH) es una neoplasia maligna de células linfoides B, habitualmente originada a nivel de los ganglios linfáticos. Durante la evolución de la enfermedad puede producirse el compromiso medular, que varía del 1 al 10% según el subtipo histopatológico, siendo éste muy raro como sitio inicial de presentación. Presentamos seis casos de LH diagnosticados inicialmente en biopsias de médula ósea.

  1. Chronic Effect of Transrectal Split-Focus Ultrasonic Ablation on Canine Prostatic Tissue

    National Research Council Canada - National Science Library

    SASAKI, Kazuaki; AZUMA, Takashi; KAWABATA, Ken-ichi; UMEMURA, Shin-ichiro; TANAKA, Ryou; YAMANE, Yoshihisa; SHIMODA, Minoru

    2006-01-01

    ... prostatic tissue without injuring surrounding tissues. The prostates of 5 dogs were transrectally treated with split-focus ablation at a peak intensity in the water of 1.7 kW/cm2 for 4 s (4 shots...

  2. Oncogenes E6-E7 de los Papilomavirus Humanos de alto riesgo detectados por PCR en Biopsias de pene incluidas en parafina

    Directory of Open Access Journals (Sweden)

    I Guerrero

    1999-01-01

    Full Text Available La alta prevalencia del papilomavirus humano (PVH, referida a nivel mundial, en lesiones genitales de ambos sexos, el rol del varón como reservorio pasivo del virus, y el incremento de la mortalidad por cáncer genital en la mujer en nuestro país, motiva la detección y correlación de los oncogenes de los PVH de alto riesgo con la neoplasia de pene. Informamos de diez casos de biopsias de carcinoma escamoso de pene, incluidos en parafina, los cuales fueron investigados para la presencia de los oncogenes E6-E7 de PVH de alto riesgo, utilizando cebadores tipo específico para los PVH -16 y 18, mediante la reacción en cadena de la polimerasa (PCR. El 40% de los casos mostró un producto de amplificación ADN E6-E7 de los PVH estudiados, correspondiendo el 75% de ellos a detección simple por PVH-18 y el 25% presentó detección mixta ADN E6 - E7 del PVH-16 y 18 simultáneamente. El producto de amplificación fue sometido a comprobación por análisis de restricción específico. La prevalencia obtenida de los oncogenes E6-E7 de los PVH de alto riesgo, usando un método tan sensible como la PCR, apoya el rol de estos virus en el proceso de carcinogénesis de la neoplasia de pene.

  3. Analysis of Preoperative Detection for Apex Prostate Cancer by Transrectal Biopsy

    OpenAIRE

    Tomokazu Sazuka; Takashi Imamoto; Takeshi Namekawa; Takanobu Utsumi; Mitsuru Yanagisawa; Koji Kawamura; Naoto Kamiya; Hiroyoshi Suzuki; Takeshi Ueda; Satoshi Ota; Yukio Nakatani; Tomohiko Ichikawa

    2013-01-01

    Background. The aim of this study was to determine concordance rates for prostatectomy specimens and transrectal needle biopsy samples in various areas of the prostate in order to assess diagnostic accuracy of the transrectal biopsy approach, especially for presurgical detection of cancer in the prostatic apex. Materials and Methods. From 2006 to 2011, 158 patients whose radical prostatectomy specimens had been evaluated were retrospectively enrolled in this study. Concordance rates for h...

  4. La biopsia oral en el contexto del precáncer y del cáncer oral Oral biopsy in the context of oral cancer and precancer

    Directory of Open Access Journals (Sweden)

    J.M. Seoane

    2008-02-01

    Full Text Available Es este artículo se revisa el papel de la biopsia oral en el diagnóstico de lesiones precancerosas y en el diagnóstico precoz del cáncer oral. Se discuten diferentes técnicas, procedimientos, materiales, indicaciones y aspectos quirúrgicos. Se propone efectuar biopsias incisionales en lesiones malignas y sospechosas de malignidad, en tanto se preconizan biopsias escisionales, cuando el tamaño lo permita, en lesiones precancerosas.This article reviews the paper of oral biopsy on the precancerous lesions diagnosis and on the oral cancer early diagnosis. Different techniques, procedures, materials, indications and other surgical aspects are debated. It proposes to do incisional biopsies on malignant lesions and on malignant suspicious lesions, while doing excisional biopsies on precancerous lesions when the size allows it.

  5. La biopsia estereotáctica en el diagnóstico de las lesiones cerebrales focales en sida Stereotactic brain biopsy in the diagnosis of focal brain lesions in AIDS

    Directory of Open Access Journals (Sweden)

    Marcelo Corti

    2008-08-01

    Full Text Available Las lesiones cerebrales focales constituyen una complicación frecuente en los pacientes con infección por el virus de la inmunodeficiencia humana (HIV y síndrome de inmunodeficiencia adquirida (sida. Durante el período comprendido entre enero de 1999 y mayo de 2007 se realizaron un total de 83 biopsias en pacientes con sida y lesiones cerebrales. Se incluyeron aquellos pacientes que no hubiesen respondido al algoritmo habitual de enfoque diagnóstico-terapéutico de estas lesiones. Todas las muestras obtenidas fueron sometidas a evaluación intraoperatoria para asegurar la obtención de material patológico y posterior análisis histopatológico y exámenes microbiológicos. De los 41 pacientes con lesiones cerebrales múltiples, 62 tenían localización supratentorial, en 4 eran infratentoriales y 17 mostraron ambas localizaciones. Cincuenta y un lesiones seleccionadas como blanco estereotáctico tuvieron refuerzo periférico del contraste. Se obtuvo material histopatológico en el 100% de los procedimientos. El diagnóstico más frecuente fue el de leucoencefalopatía multifocal progresiva (LEMP con 24 casos (29%, seguido del linfoma primario del sistema nervioso central (LPSNC con 19 diagnósticos (23% y de toxoplasmosis en 13 pacientes (15.7%. Se comprobó una relación significativa entre los diagnósticos histopatológicos y la localización de las lesiones y entre los diagnósticos histopatológicos y el comportamiento de las imágenes luego de la administración de la sustancia de contraste. El rédito diagnóstico alcanzó el 90.3% (75 biopsias. La morbiletalidad en esta serie fue de 2.4%. La biopsia cerebral estereotáctica permitió alcanzar el diagnóstico etiológico y adecuar el enfoque terapéutico en la mayoría de los pacientes de esta serie.Focal brain lesions are frequent complications among HIV/AIDS patients. Between January 1999 and May 2007, 83 procedures of stereotactic brain biopsies in HIV/AIDS patients with focal

  6. Hallazgos patológicos en adenopatías de pacientes con infección por HIV

    Directory of Open Access Journals (Sweden)

    Federico Rodríguez-Vega

    2017-01-01

    Resultados. Se evaluaron 120 historias clínicas, con diagnósticos distribuidos así: 58 % de origen infeccioso, 32,5 % con cambios reactivos, 6,6 % de origen neoplásico y 2,5 % normales. El diagnóstico más frecuente fue la tuberculosis (48,3 %. En 14,1 % de los pacientes, la biopsia de ganglio linfático sirvió para detectar otra infección oportunista además de las encontradas en otros órganos. Conclusión. La biopsia de ganglio linfático en pacientes con HIV es una herramienta útil que permite el diagnóstico de enfermedades infecciosas y neoplásicas graves, y que debería hacerse de rutina en todos los pacientes con adenopatías

  7. Evaluacion de la biopsia transpedicular guiada por TAC Avaliação da biópsia transpedicular guiada por TC Evaluation of transpedicular percutaneous biopsy guided by CT

    Directory of Open Access Journals (Sweden)

    Luis Miguel Rosales Olivarez

    2012-09-01

    Full Text Available OBJETIVO: Valorar la utilidad de la biopsia transpedicular percutánea guiada por Tomografía Axial Computarizada en conjunto con la sistematización de estudios como pruebas diagnósticas de la etiología de la destrucción vertebral. MÉTODOS: Estudio de serie de casos prospectivo transversal de 21 pacientes a los que se les realizó biopsia transpedicular percutánea guiada por Tomografía Axial Computarizada y estudios de laboratorio y gabinete de marzo a julio del 2011, para evaluar su utilidad en el diagnóstico de destrucción vertebral. RESULTADOS: Fueron 21 pacientes, 14 hombres y 7 mujeres, con edad media de 59,2 años, cuyos niveles más afectados estuvieron en L1, L2 y L3. El reporte de la biopsia tuvo una precisión diagnóstica del 90,4%. En 2 casos se realizó correlación clínica entre biopsia y sistematización de estudios para obtener el diagnóstico. CONCLUSIÓN: La biopsia guiada por Tomografía Axial Computarizada es una técnica sencilla, útil, de bajo costo y eficaz en el estudio de la destrucción vertebral; la sistematización de estudios permite corroborar el diagnóstico de la biopsia.OBJETIVO: Avaliar a utilidade da biópsia transpedicular percutânea guiada por tomografia axial computadorizada em conjunto com a sistematização de estudos, como exames diagnósticos da etiologia da destruição vertebral. MÉTODOS: Estudo de série de casos, prospectivo e transversal de 21 pacientes submetidos à biópsia transpedicular percutânea guiada por tomografia axial computadorizada e exames laboratoriais e radiológicos, de março a julho de 2011, para avaliar sua utilidade no diagnóstico de destruição vertebral. RESULTADOS: Foram analisados 21 pacientes, 14 homens e 7 mulheres, com média de idade de 59,2 anos, cujos níveis mais afetados foram L1, L2 e L3. O laudo da biópsia teve precisão diagnóstica de 90,4%. Em dois casos, realizou-se a correlação clínica entre biópsia e sistematização de exames para obter

  8. EVALUACIÓN DE DOS MÉTODOS DE EXTRACCIÓN DE ADN A PARTIR DE BIOPSIAS FIJADAS EN FORMALINA Y EMBEBIDAS EN PARAFINA EN CONDICIONES NO ÓPTIMAS

    Directory of Open Access Journals (Sweden)

    JAVIER ANDRÉS BUSTAMANTE

    2011-01-01

    Full Text Available Los tejidos de archivo son material de incalculable valor para estudios retrospectivos que requieran la aplicación de análisis moleculares. Existen múltiples métodos de extracción de ADN a partir de este tipo de muestras. No obstante, la mayoría de mé- todos toman mucho tiempo y los reactivos empleados contribuyen a la fragmentación del ADN. Con el objetivo de optimizar dos métodos de extracción de ADN a partir de tejidos embebidos en parafina en condiciones no óptimas, se seleccionaron 47 bloques en parafina que contenían biopsias de pleura, pulmón y pericardio correspondientes a 24 pacientes (66,6% hombres mayores de 18 años, con inflamación granulomatosa crónica, remitidos al Departamento de Patología, Hospital Universitario del Valle entre 2002 y 2007. Se realizaron 10 cortes a cada muestra y se sometieron a dos métodos de extracción de ADN: 1. convencional y 2. QIAamp-DNA mini kit ® . La eficiencia del ADN fue valorada por espectrofotometría y amplificación del gen GAPDH. La concentración de ADN de las muestras extraídas por el método convencional fue de 65,52 ng/μL ±11,47 (promedio ± EE y la relación 260/280 varió entre 0,52 y 2,30. De las muestras extraídas por el método comercial, la concentración media de ADN fue 60,89 ng/μL ± 6,02, con una absorbancia que osciló entre 0 y 2,64. El ADN obtenido fue sometido a PCR, de 47 muestras extraídas por ambos métodos, 25 y 23 respectivamente amplificaron exitosamente el gen GAPDH. Los métodos usados para la obtención de ADN presentaron un desempeño similar, revelando así su potencial utilidad en estudios retrospectivos a partir de biopsias embebidas en parafina en condiciones inadecuadas.

  9. Evaluación de dos métodos de extracción de ADN a partir de biopsias fijadas en formalina y embebidas en parafina en condiciones no optimas

    Directory of Open Access Journals (Sweden)

    Bravo Luis Eduardo

    2011-08-01

    Full Text Available Los tejidos de archivo son un material de incalculable valor para estudios retrospectivos que requieran la aplicación de análisis moleculares. Existen múltiples métodos de extracción de ADN a partir de este tipo de muestras. No obstante, la mayoría de m��todos toman mucho tiempo y los reactivos empleados contribuyen a la fragmentación del ADN. Con el objetivo de optimizar dos métodos de extracción de ADN a partir de tejidos embebidos en parafina en condiciones no optimas. Se seleccionaron 47 bloques en parafina que contenían biopsias de pleura, pulmón y pericardio correspondientes a 24 pacientes (66,66%hombres mayores de 18 años, con inflamación granulomatosa crónica, remitidos al Departamento de Patología del Hospital Universitario del Valle entre 2002-2007. A cada muestra se le realizaron 10 cortes y se sometieron a dos métodos de extracción de ADN: 1.Convencional y 2.QIAamp-DNA mini kit®. La eficiencia del ADN fue valorada por espectrofotometría y amplificación del gen GAPDH. La concentración de ADN de las muestras extraídas por el método convencional fue de 65.52ng/µl ±11.47 (promedio±EE y la relación 260/280 vario entre 0.52 y 2.30. De las muestras extraídas por el método comercial, la concentración media de ADN fue 60.89ng/µl±6.02, con una absorbancia que oscilo entre 0 y 2.64. El ADN obtenido fue sometido a PCR, de 47 muestras extraídas por ambos métodos, 25 y 23 respectivamente amplificarón exitosamente el gen GAPDH. Los métodos usados para la obtención de ADN presentaron un desempeño similar, revelando así su potencial utilidad en estudios retrospectivos a partir de biopsias embebidas en parafina en condiciones inadecuadas.

  10. Framework for 3D TransRectal Ultrasound

    CERN Document Server

    Mozer, Pierre; Chevreau, G; Daanen, Vincent; Moreau-Gaudry, Alexandre; Troccaz, Jocelyne

    2008-01-01

    Prostate biopsies are mainly performed under 2D TransRectal UltraSound (TRUS) control by sampling the prostate according to a predefined pattern. In case of first biopsies, this pattern follows a random systematic plan. Sometimes, repeat biopsies can be needed to target regions unsampled by previous biopsies or resample critical regions (for example in case of cancer expectant management or previous prostatic intraepithelial neoplasia findings). From a clinical point of view, it could be useful to control the 3D spatial distribution of theses biopsies inside the prostate. Modern 3D-TRUS probes allow acquiring high-quality volumes of the prostate in few seconds. We developed a framework to track the prostate in 3D TRUS images. It means that if one acquires a reference volume at the beginning of the session and another during each biopsy, it is possible to determine the relationship between the prostate in the reference and the others volumes by aligning images. We used this tool to evaluate the ability of a si...

  11. Transrectal ultrasound of the prostate bed after collagen injection

    Energy Technology Data Exchange (ETDEWEB)

    Salomon, C.G.; Dudiak, C.M.; Pyle, J.M.; Wheeler, J.S.; Waters, W.B.; Flanigan, R.C. [Loyola Univ. Medical Center, Maywood, IL (United States)

    1996-03-01

    Transurethral injection of collagen (TCI) may be used to treat urinary incontinence following radical prostatectomy for prostate cancer. The transrectal ultrasound (TRUS) findings after TCI are described in this report. TRUS exams of four postprostatectomy patients who had undergone TCI were reviewed. Findings were correlated with pathologic specimens obtained at TRUS-guided core biopsy. These histologic specimens were compared with others from postprostatectomy patients who had not undergone TCI. Well defined bladder apex masses of uniform echogenicity, hypoechoic to adjacent fat and muscle, were identified sonographically in all TCI patients. Masses from which positive biopsies were obtained were similar in appearance to those with no malignant. Hypocellular fibrous tissue and foci of acellular loose connective tissue were identified in the biopsies of those patients who had undergone TCI No acellular areas were identified in specimens from patients who had not had TCI. Sequelae of to should be included in the differential diagnosis of perianastomotic masses in postprostatectomy patients. However, the need for biopsy is not obviated as residual or recurrent prostate carcinoma may coexist. 14 refs., 4 figs.

  12. The impact of transrectal prostate biopsy on erectile function.

    Science.gov (United States)

    Linden-Castro, E; Pelayo-Nieto, M; Espinosa-Perezgrovas, D; Rubio-Arellano, E D; Catalán-Quinto, G; Guzmán-Hernández, F; Morales-Covarrubias, J A; Cortez-Betancourt, R

    2016-09-01

    To assess erectile function at different periods of time in patients who undergo transrectal prostate biopsy (TRPB). A total of 364 patients underwent TRPB. All of the patients were assessed using the International Index of Erectile Function-5 (IIEF-5). All patients with a positive result for cancer or with previous erectile dysfunction in the initial assessment were excluded. Ninety-three patients were included and were assessed before the biopsy and at 4, 12 and 24 weeks after the TRPB, using the IIEF-5 and assessing erectile function across these time periods. We assessed 93 patients. During the first prebiopsy assessment, 100% of the patients scored ≥22 points. In the first postbiopsy evaluation at 4 weeks, 66.6% scored ≥ 22 points, and 33.3% had erectile dysfunction, thereby indicating a statistically significant reduction in the IIEF-5 score (P=.001). In the second postbiopsy evaluation, only 9.1% patients still had mild to moderate erectile dysfunction (P=.04). By the end, 92.48% of the patients scored ≥ 22 points, and 7.52% still had mild erectile dysfunction, without presenting a significant difference (P=.1). After a TRPB, the drop in IIEF-5 scores and the presence of erectile dysfunction are temporary and transient, with greater impairment during the first month following the procedure and improvement starting after the first month, with almost total recovery at 6 months. Copyright © 2016 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.

  13. Status of transrectal ultrasound imaging of the prostate.

    Science.gov (United States)

    Aigner, Friedrich; Mitterberger, Michael; Rehder, Peter; Pallwein, Leo; Junker, Daniel; Horninger, Wolfgang; Frauscher, Ferdinand

    2010-05-01

    To describe the current and new developments in transrectal ultrasound (US) imaging of the prostate. Grayscale imaging of the prostate is the standard method for diagnostic evaluation and biopsy guidance. Color Doppler (CD) imaging, including CD and power Doppler US, allows for detection of macrovascularity and may therefore be helpful for assessment of prostatic blood flow. The use of US microbubbles for CD imaging and new contrast-specific techniques enable assessment of prostate microvascularity associated with prostate cancer (PCa). Recently, real-time elastography has been introduced to improve detection of cancer based upon changes in tissue stiffness. Contrast-enhanced CD imaging has shown to enable PCa detection by performing targeted biopsies into suspicious areas. Comparisons between systematic and contrast-enhanced targeted biopsies have shown that the targeted approach detects more cancers and cancers with higher Gleason scores with a reduced number of biopsy cores. New microbubble-specific US techniques can improve sensitivity and specificity of US imaging for PCa detection. Real-time elastography has been demonstrated to be useful for the detection of PCa, and may further improve PCa staging. The new US techniques seem to have the potential to improve PCa detection, and also PCa grading and staging. As these diagnostic methods improve, the ultimate hope is to eliminate biopsy in patients without cancer.

  14. AVALIAÇÃO QUANTITATIVA E QUALITATIVA, DA TÉCNICA DE BIOPSIA RENAL “DE JANELA” EM CÃES

    Directory of Open Access Journals (Sweden)

    Veridiana Maria Brianezi Dignani de Moura

    2006-10-01

    Full Text Available Foram biopsiados os rins de 86 cães pela técnica “de janela”, utilizando agulhas Vim Tru-Cut, com o objetivo de avaliar o número de glomérulos presentes nas amostras, determinar a qualidade diagnóstica delas, bem como estabelecer o melhor rim a ser biopsiado nos casos de nefropatia canina em que a biopsia é indicada como meio de diagnóstico. A média de glomérulos presentes nas biopsias dos rins direito e esquerdo foi 17,53 e 15,93 glomérulos por amostra, respectivamente, o que significa que não houve diferença estatística significativa. No entanto, as biopsias dos rins esquerdos apresentaram maior número de amostras sem glomérulos, dado que indica que elas são impróprias para o diagnóstico. Diante desses resultados conclui-se que o rim direito é o mais apropriado para a realização dessa técnica, uma vez que ele apresenta menor possibilidade de ocorrência de amostras sem glomérulos. PALAVRAS-CHAVE: Cão, biopsia renal “de janela”, glomérulo.

  15. Manejo de las lesiones mamarias de alto riesgo diagnosticadas mediante biopsia percutánea

    Directory of Open Access Journals (Sweden)

    M. Castro Barba

    2013-01-01

    Este trabajo tiene como objetivo revisar la literatura y presentar la evidencia actual sobre el manejo de las hiperplasias atípicas ductal y lobulillar, el carcinoma lobulillar in situ, la cicatriz radiada y las lesiones columnares, papilares y de tipo mucocele, luego del diagnóstico con técnicas de intervencionismo percutáneo.

  16. Development of a PET-Transrectal Ultrasound Prostate Imaging System

    Science.gov (United States)

    Huber, Jennifer S.; Peng, Qiyu.; Moses, William W.; Reutter, Bryan W.; Pouliot, Jean; Hsu, I. Chow

    2011-06-01

    Multimodality imaging has an increasing role in the management of a large number of diseases, particularly if both functional and structural information are acquired and accurately registered. Transrectal ultrasound (TRUS) imaging is currently an integral part of prostate cancer diagnosis and treatment procedures, providing high-resolution anatomical detail of the prostate region. Positron Emission Tomography (PET) imaging with 11C-choline is a sensitive functional imaging technique that can identify biochemical states associated with prostate cancer. We believe that merging these prostate imaging technologies will help identify the location and aggressiveness of prostate cancer. We envision using dual PET-TRUS prostate imaging to guide biopsy, guide treatment procedures, and detect local recurrence earlier than is currently possible. Hence, we have developed a dual PET-TRUS prostate imaging system and protocol designed to allow accurate 3-D image registration. We have evaluated this PET-TRUS system by performing dual PET-TRUS imaging of custom phantoms. We describe here our dual-modality imaging system, custom phantoms and phantom study results. We also discuss our investigation of the PET-TRUS registration accuracy. We measure an average PET-TRUS registration error for our phantom studies of 2.1 ±1.7 mm in the x direction, 1.9 ±1.6 mm in the y direction, and 0.6 ±0.2 mm in the z direction. This registration accuracy is sufficient for some clinical applications such as biopsy guidance and early detection of recurrence.

  17. Transrectal ultrasonography in infertile patients with persistently elevated bacteriospermia

    Institute of Scientific and Technical Information of China (English)

    Sandro La Vignera; Aldo E. Calogero; Alessandro Arancio; Roberto Castighone; Gaetano De Grande; Enzo Vicari

    2008-01-01

    Aim: To identify and define prostate and seminal vesicle abnormalities in patients with chronic male accessory gland infection (MAGI) who failed to respond to antibacterial treatment. Methods: We selected 67 consecutive patients with MAGI and persistently elevated bacteriospermia (≥ 106 colony forming units [CFU]/mL) after three antibiotic courses. Fourteen infertile patients with initial chronic microbial (≥ 106 CFU/mL) MAGI who responded to antibac- terial treatment (< 103 CFU/mL) served as a control group. All patients and controls underwent transrectal ultrasonog- raphy (TRUS) scans and semen analysis. Patients with low seminal plasma volume (< 1.5 mL) underwent both pre- ejaculatory and post-ejaculatory TRUS examination. Results: TRUS revealed multiple abnormalities indicative of: (I) bilaterally extended prostato-vesiculitis (group A: 52 cases, 77.6%) (nine of these patients also had micro-emphyse- matous prostate abscess); and (ii) prostato-vesiculitis with unilateral or bilateral sub-obstruction of the ejaculatory ducts (group B: 15 cases, 22.4%). Mean sperm concentration, total sperm number, ejaculate volume and pH value were significantly higher in group A than in group B. In addition, sperm forward motility and the percentage of normal forms were significantly worse than in controls, whereas leukocyte concentration was significantly higher in group A. Group B patients had all sperm parameters, but their pH values, significantly different from those of controls. Confusion: Although antibiotic therapy is considered suitable when microbial MAGI is suspected, it is impossible to account for a poor response to antibiotics merely on the basis of conventional criteria (clinical history, physical and ejaculate signs). Thus, TRUS may be helpful in the follow-up of these patients.

  18. The future perspectives in transrectal prostate ultrasound guided biopsy

    Directory of Open Access Journals (Sweden)

    Sung Il Hwang

    2014-12-01

    Full Text Available Prostate cancer is one of the most common neoplasms in men. Transrectal ultrasound (TRUS-guided systematic biopsy has a crucial role in the diagnosis of prostate cancer. However, it shows limited value with gray-scale ultrasound alone because only a small number of malignancies are visible on TRUS. Recently, new emerging technologies in TRUS-guided prostate biopsy were introduced and showed high potential in the diagnosis of prostate cancer. High echogenicity of ultrasound contrast agent reflect the increased status of angiogenesis in tumor. Molecular imaging for targeting specific biomarker can be also used using ultrasound contrast agent for detecting angiogenesis or surface biomarker of prostate cancer. The combination of TRUS-guided prostate biopsy and ultrasound contrast agents can increase the accuracy of prostate cancer diagnosis. Elastography is an emerging ultrasound technique that can provide the information regarding tissue elasticity and stiffness. Tumors are usually stiffer than the surrounding soft tissue. In two types of elastography techniques, shearwave elastography has many potential in that it can provide quantitative information on tissue elasticity. Multiparametric magnetic resonance imaging (MRI from high resolution morphologic and functional magnetic resonance (MR technique enables to detect more prostate cancers. The combination of functional techniques including apparent diffusion coefficient map from diffusion weighted imaging, dynamic contrast enhanced MR and MR spectroscopy are helpful in the localization of the prostate cancer. MR-ultrasound (US fusion image can enhance the advantages of both two modalities. With MR-US fusion image, targeted biopsy of suspicious areas on MRI is possible and fusion image guided biopsy can provide improved detection rate. In conclusion, with recent advances in multiparametric-MRI, and introduction of new US techniques such as contrast-enhanced US and elastography, TRUS-guided biopsy

  19. The future perspectives in transrectal prostate ultrasound guided biopsy.

    Science.gov (United States)

    Hwang, Sung Ii; Lee, Hak Jong

    2014-12-01

    Prostate cancer is one of the most common neoplasms in men. Transrectal ultrasound (TRUS)-guided systematic biopsy has a crucial role in the diagnosis of prostate cancer. However, it shows limited value with gray-scale ultrasound alone because only a small number of malignancies are visible on TRUS. Recently, new emerging technologies in TRUS-guided prostate biopsy were introduced and showed high potential in the diagnosis of prostate cancer. High echogenicity of ultrasound contrast agent reflect the increased status of angiogenesis in tumor. Molecular imaging for targeting specific biomarker can be also used using ultrasound contrast agent for detecting angiogenesis or surface biomarker of prostate cancer. The combination of TRUS-guided prostate biopsy and ultrasound contrast agents can increase the accuracy of prostate cancer diagnosis. Elastography is an emerging ultrasound technique that can provide the information regarding tissue elasticity and stiffness. Tumors are usually stiffer than the surrounding soft tissue. In two types of elastography techniques, shearwave elastography has many potential in that it can provide quantitative information on tissue elasticity. Multiparametric magnetic resonance imaging (MRI) from high resolution morphologic and functional magnetic resonance (MR) technique enables to detect more prostate cancers. The combination of functional techniques including apparent diffusion coefficient map from diffusion weighted imaging, dynamic contrast enhanced MR and MR spectroscopy are helpful in the localization of the prostate cancer. MR-ultrasound (US) fusion image can enhance the advantages of both two modalities. With MR-US fusion image, targeted biopsy of suspicious areas on MRI is possible and fusion image guided biopsy can provide improved detection rate. In conclusion, with recent advances in multiparametric-MRI, and introduction of new US techniques such as contrast-enhanced US and elastography, TRUS-guided biopsy may evolve toward

  20. Fluoroquinolone resistant rectal colonization predicts risk of infectious complications after transrectal prostate biopsy.

    Science.gov (United States)

    Liss, Michael A; Taylor, Stephen A; Batura, Deepak; Steensels, Deborah; Chayakulkeeree, Methee; Soenens, Charlotte; Rao, G Gopal; Dash, Atreya; Park, Samuel; Patel, Nishant; Woo, Jason; McDonald, Michelle; Nseyo, Unwanaobong; Banapour, Pooya; Unterberg, Stephen; Ahlering, Thomas E; Van Poppel, Hendrik; Sakamoto, Kyoko; Fierer, Joshua; Black, Peter C

    2014-12-01

    Infection after transrectal prostate biopsy has become an increasing concern due to fluoroquinolone resistant bacteria. We determined whether colonization identified by rectal culture can identify men at high risk for post-transrectal prostate biopsy infection. Six institutions provided retrospective data through a standardized, web based data entry form on patients undergoing transrectal prostate biopsy who had rectal culture performed. The primary outcome was any post-transrectal prostate biopsy infection and the secondary outcome was hospital admission 30 days after transrectal prostate biopsy. We used chi-square and logistic regression statistical analysis. A total of 2,673 men underwent rectal culture before transrectal prostate biopsy from January 1, 2007 to September 12, 2013. The prevalence of fluoroquinolone resistance was 20.5% (549 of 2,673). Fluoroquinolone resistant positive rectal cultures were associated with post-biopsy infection (6.6% vs 1.6%, p Fluoroquinolone resistant positive rectal culture increased the risk of infection (OR 3.98, 95% CI 2.37-6.71, p fluoroquinolone prophylaxis, the infection and hospitalization proportion increased to 8.2% (28 of 343) and 6.1% (21 of 343), with OR 4.77 (95% CI 2.50-9.10, p fluoroquinolone resistant bacteria isolates were Escherichia coli (83.7%). Limitations include the retrospective study design, nonstandardized culture and interpretation of resistance methods. Colonization of fluoroquinolone resistant organisms in the rectum identifies men at high risk for infection and subsequent hospitalization from prostate biopsy, especially in those with fluoroquinolone prophylaxis only. Copyright © 2014 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  1. Hallazgos histopatológicos en niños con diagnóstico de alergia a las proteínas de la leche de la vaca

    Directory of Open Access Journals (Sweden)

    R. Cervantes-Bustamante

    2015-04-01

    Conclusiones: Entre el 40-45% de los casos tuvieron el criterio histológico de más de 15-20 eosinófilos por campo siendo el sitio más afectado el rectosigmoides. Por lo tanto, se sugiere realizar panendoscopia y rectosigmoidoscopia con toma de biopsias y recuento de eosinófilos.

  2. Tratamiento, mediante bloqueo de moléculas CD20 con Rituximab, en miopatías Inflamatorias Idiopáticas refractarias a tratamiento convencional

    OpenAIRE

    Chinchilla Palomares, Eduardo

    2012-01-01

    Las miopatías inflamatorias idiopáticas (MII) constituyen un grupo heterogéneo de enfermedades adquiridas, de probable mecanismo inflamatorio autoinmune, que se caracterizan por debilidad muscular e infiltrado inflamatorio local o difuso, junto con necrosis de las fibras musculares, en la biopsia muscular. Afectan preferentemente a la musculatura estriada. Dentro de este grupo se incluyen tres variantes principales: la dermatomiositis (DM), la polimiositis (PM) y la miositis con cuerpos de in...

  3. Tuberculosis peritoneal con niveles elevados de CA 125

    Directory of Open Access Journals (Sweden)

    Andrés José Gómez-Aldana

    2013-09-01

    Full Text Available Resumen La tuberculosis peritoneal hace parte de los diagnósticos diferenciales de ascitis; sin embargo, su documentación está dada por la presencia de granulomas necrotizantes al igual que el crecimiento de micobacterias en las muestras tomadas del peritoneo. Se presenta el caso de una paciente con dolor abdominal y ascitis en quien se documentaron lesiones nodulares en cavidad peritoneal, con niveles marcadamente elevados de "Antígeno Carbohidrato o Antígeno Cáncer" CA 125, sin cambios en otros órganos, realizando biopsias de peritoneo, con documentación de granulomas necrotizantes y crecimiento de micobacterias en el cultivo, por lo que se instauró tratamiento con adecuada respuesta logrando disminución progresiva de la ascitis y ganancia de peso.

  4. Feasibility of a pneumatically actuated MR-compatible robot for transrectal prostate biopsy guidance

    NARCIS (Netherlands)

    Yakar, D.; Schouten, M.G.; Bosboom, D.G.H.; Barentsz, J.O.; Scheenen, T.W.J.; Futterer, J.J.

    2011-01-01

    PURPOSE: To assess the feasibility of using a remote-controlled, pneumatically actuated magnetic resonance (MR)-compatible robotic device to aid transrectal biopsy of the prostate performed with real-time 3-T MR imaging guidance. MATERIALS AND METHODS: This prospective study was approved by the ethi

  5. Transrectal ultrasonography and magnetic resonance imaging in the staging of rectal cancer. Effect of experience

    DEFF Research Database (Denmark)

    Rafaelsen, Søren R; Sørensen, Torben; Jakobsen, Anders

    2008-01-01

    OBJECTIVE: To evaluate the effect of experience on preoperative staging of rectal cancer using magnetic resonance imaging (MRI) and transrectal ultrasound (TRUS). MATERIAL AND METHODS: From January 2002 to May 2006, 134 consecutive patients with biopsy-proven rectal cancer were examined with a 1....... In addition to this supervision, the person responsible for staging should be trained through a defined training programme....

  6. Malakoplakia of the prostate diagnosed by elevated PSA level and transrectal prostate biopsy

    Directory of Open Access Journals (Sweden)

    Sacit Nuri Görgel

    2011-04-01

    Full Text Available Malakoplakia is an inflammation which is thought to develop secondary to chronic Escherichia coli infections. Although often seen in the genitourinary tract, it can also be seen in colon, stomach, lung, liver, bone, uterus, and skin. In this case report, we present prostatic malakoplakia diagnosed by elevated prostate-specific antigen level and transrectal prostate biopsy.

  7. Transrectal Ultrasound-guided Systematic 13-Core Prostate Biopsy to Diagnose Prostate Carcinoma

    Institute of Scientific and Technical Information of China (English)

    Liuping Yang; Junhong Deng; Hong Zhong; Jianbo Hu; Hongai Wei; Liangsheng Wang

    2005-01-01

    OBJECTIVE To evaluate the clinical value of transrectal ultrasound guided systematic 13-core prostate biopsy.METHODS A total of 213 patients referred for abnormal digital rectal examination and/or with a prostate specific antigen of 4 ng/ml or greater underwent transrectal ultrasound guided systematic 13-core prostate biopsy. This procedure was conducted in addition to the standard sextant biopsies in which cores were taken from the far lateral and middle regions of the gland as described by Eskew. Fathological findings of the additional regions were compared with those of the sextant regions.RESULTS Of the 213 patients 31% had cancer on biopsy (66/213). Of the 66 patients with prostate cancer 14 (21%) had carcinoma only in the additional regions, which would have remained undetected had the sextant biopsy technique been used alone (P<0.05). No severe complications occurred among the patients who underwent transrectal ultrasound guided systematic 13-core prostate biopsy.CONCLUSION Our data demonstrated that transrectal ultrasound guided systematic 13-core prostate biopsy can significantly increase the cancer detection rate. It is safe and efficacious, and should be recommended for use clinically.

  8. Midline fascial plication under continuous digital transrectal control: which factors determine anatomic outcome?

    NARCIS (Netherlands)

    Milani, A.L.; Withagen, M.I.J.; Schweitzer, K.J.; Janszen, E.W.; Vierhout, M.E.

    2010-01-01

    INTRODUCTION AND HYPOTHESIS: The aim of the study was to report anatomic and functional outcome of midline fascial plication under continuous digital transrectal control and to identify predictors of anatomic failure. METHODS: Prospective observational cohort. Anatomic success defined as POP-Q stage

  9. Transrectal ultrasound of the prostatic urethra related to urodynamically assessed urethral resistance. A pilot study

    NARCIS (Netherlands)

    R. van Mastrigt (Ron); R. Kranse (Ries); H. Jansen

    1994-01-01

    textabstractIn this pilot study on 17 men who underwent urodynamic investigation for various dysuric complaints, real-time transrectal ultrasonography (TRUS) was performed. From the images anatomical parameters were identified that correlated with obstructive urodynamic findings and urethral resista

  10. Comparison of transrectal photoacoustic, Doppler, and magnetic resonance imaging for prostate cancer detection

    Science.gov (United States)

    Ishihara, Miya; Horiguchi, Akio; Shinmoto, Hiroshi; Tsuda, Hitoshi; Irisawa, Kaku; Wada, Takatsugu; Asano, Tomohiko

    2016-03-01

    Transrectal ultrasonography (TRUS) is the most popular imaging modality for diagnosing and treating prostate cancer. TRUS-guided prostate biopsy is mandatory for the histological diagnosis of patients with elevated serum prostatespecific antigen (PSA), but its diagnostic accuracy is not satisfactory due to TRUS's low resolution. As a result, a considerable number of patients are required to undergo an unnecessary repeated biopsy. Photoacoustic imaging (PAI) can be used to provide microvascular network imaging using hemoglobin as an intrinsic, optical absorption molecule. We developed an original TRUS-type PAI probe consisting of a micro-convex array transducer with an optical illumination system to provide superimposed PAI and ultrasound images. TRUS-type PAI has the advantage of having much higher resolution and greater contrast than does Doppler TRUS. The purpose of this study was to demonstrate the clinical feasibility of the transrectal PAI system. We performed a clinical trial to compare the image of the cancerous area obtained by transrectal PAI with that obtained by TRUS Doppler during prostate biopsy. The obtained prostate biopsy cores were stained with anti-CD34 antibodies to provide a microvascular distribution map. We also confirmed its consistency with PAI and pre-biopsy MRI findings. Our study demonstrated that transrectal identification of tumor angiogenesis under superimposed photoacoustic and ultrasound images was easier than that under TRUS alone. We recognized a consistent relationship between PAI and MRI findings in most cases. However, there were no correspondences in some cases.

  11. Feasibility of a 2nd generation MR-compatible manipulator for transrectal prostate biopsy guidance

    NARCIS (Netherlands)

    Bomers, J.G.R.; Bosboom, D.G.H.; Tigelaar, G.H.; Sabisch, J.; Futterer, J.J.; Yakar, D.

    2017-01-01

    OBJECTIVES: To assess the feasibility of a 2nd generation MR-compatible, remote-controlled manipulator (RCM) as an aid to perform MR-guided transrectal prostate biopsy in males with suspicion of prostate cancer (PCa). METHODS: This prospective phase I study was approved by the local ethical

  12. Módulo para solicitudes de gammagrafía ósea en pacientes con cáncer

    OpenAIRE

    Morales, Rosanna; Vásquez, Edinson; Cano, Roque; Díaz, Pepe; Vásquez, Mario; Vásquez, María; Rojas, Peter

    2014-01-01

    Se reporta la aplicación de un software que permite registrar con datos completos y pertinentes del paciente, la solicitud para la realización de los exámenes de gammagrafía ósea, con la finalidad que cada información sea consultada adecuadamente y el paciente sea atendido con eficiencia en los servicios de medicina nuclear. La gammagrafía ósea es un estudio de uso frecuente que permite diagnosticar la existencia de un cáncer primario, dirigir un estudio para biopsia o reportar la diseminació...

  13. Prospective Comparison of Magnetic Resonance Imaging, Transrectal and Transperineal Sonography, and Surgical Findings in Complicated Perianal Crohn Disease.

    Science.gov (United States)

    Bor, Renáta; Farkas, Klaudia; Bálint, Anita; Szűcs, Mónika; Ábrahám, Szabolcs; Milassin, Ágnes; Rutka, Mariann; Nagy, Ferenc; Milassin, Péter; Szepes, Zoltán; Molnár, Tamás

    2016-11-01

    Magnetic resonance imaging (MRI) and transrectal sonography are the two accepted imaging modalities for evaluation of perianal fistulas and abscesses. Transperineal sonography is a new technique that is easy to learn and can be performed at any time. The purpose of this study was to prospectively compare the diagnostic accuracy of MRI, transrectal sonography, and transperineal sonography with surgical findings in patients with perianal Crohn disease. All patients with perianal Crohn disease underwent MRI, transrectal sonography, and transperineal sonography within a few days before surgery. Fistulas were classified as simple (43.8%) or complex (52.2%) based on surgical findings. Twenty-three patients with active perianal Crohn disease (12 women and 11 men; mean age, 29.9 years; current therapy: antibiotics, 69.6%; azathioprine, 56.5%; and biologics, 73.9%; previous surgery, 26.1%; and proportion of smokers, 39.1%) were included. Sensitivity values for MRI, transrectal sonography, and transperineal sonography for diagnosis of fistulas were 84.6%, 84.6%, and 100%, respectively. Transperineal sonography was more sensitive for diagnosis of perianal abscesses than MRI and transrectal sonography (100%, 58.8%, and 92.8%). Transperineal sonography is a very accurate diagnostic method with outstanding sensitivity compared with MRI and transrectal sonography for evaluation of complicated perianal Crohn disease. Due to its simplicity and low cost, it is recommended that transperineal sonography be the first diagnostic modality in these cases. © 2016 by the American Institute of Ultrasound in Medicine.

  14. The results of transrectal prostate biopsy in patients with low levels of prostate specific antigen

    Directory of Open Access Journals (Sweden)

    Ahmet Ali Sancaktutar

    2012-06-01

    Full Text Available Objectives: The aim of this study is to evaluate the resultsof prostate biopsy of patients who had the prostatespecificantigen (PSA levels below 4 ng/ml.Material and methods: The medical records of 63 patientswho underwent transrectal prostate biopsy, betweenJanuary 2005 and December 2011, due to suspicionof prostate cancer with the PSA levels under 4 ng/mlwere retrospectively reviewed.Results: Transrectal Prostate biopsy was performed to63 patients. Prostate cancer was detected in 12 (19%patients. The mean value of PSA was 2.5 ng/ml. TheGleason score of Prostate cancer patients was 6,8 (5-7and the number of positive cores were 3.Conclusions: The rate of prostate cancer was found as19% in patients with levels of PSA under 4 ng/ml and thisratio is compatible with the results of previous reports.

  15. Mapping of transrectal ultrasonographic prostate biopsies: quality control and learning curve assessment by image processing

    CERN Document Server

    Mozer, Pierre; Chevreau, Gregoire; Moreau-Gaudry, Alexandre; Bart, Stephane; Renard-Penna, Raphaele; Comperat, Eva; Conort, Pierre; Bitker, Marc-Olivier; Chartier-Kastler, Emmanuel; Richard, Francois; Troccaz, Jocelyne

    2009-01-01

    Objective: Mapping of transrectal ultrasonographic (TRUS) prostate biopsies is of fundamental importance for either diagnostic purposes or the management and treatment of prostate cancer, but the localization of the cores seems inaccurate. Our objective was to evaluate the capacities of an operator to plan transrectal prostate biopsies under 2-dimensional TRUS guidance using a registration algorithm to represent the localization of biopsies in a reference 3-dimensional ultrasonographic volume. Methods: Thirty-two patients underwent a series of 12 prostate biopsies under local anesthesia performed by 1 operator using a TRUS probe combined with specific third-party software to verify that the biopsies were indeed conducted within the planned targets. RESULTS: The operator reached 71% of the planned targets with substantial variability that depended on their localization (100% success rate for targets in the middle and right parasagittal parts versus 53% for targets in the left lateral base). Feedback from this ...

  16. Antibiotic prophylaxis for transrectal ultrasound biopsy of the prostate in Ireland.

    LENUS (Irish Health Repository)

    Smyth, L G

    2012-03-01

    Prostate cancer is the most common solid cancer affecting men in Ireland. Transrectal ultrasound (TRUS) biopsies of the prostate are routinely performed to diagnose prostate cancer. They are, in general, a safe procedure but are associated with a significant risk of infective complications ranging from fever, urinary tract infection to severe urosepsis. At present, there are no recommended national guidelines on the use of antibiotic prophylaxis to minimise the risk of infective complications post-TRUS biopsy.

  17. A Rectourethral Fistula due to Transrectal High-Intensity Focused Ultrasound Treatment: Diagnosis and Management

    OpenAIRE

    2012-01-01

    Colovesical fistula (CVF) is an abnormal connection between the enteric and the urinary systems. The rectourethral fistula (RUF) is a possible but extremely rare complication of treatment of prostate cancer with “transrectal High-Intensity Focused Ultrasound (HIFU) treatment.” We present a case of CVF due to HIFU treatment of recurrent prostate cancer. The case was assessed with cystography completed with a pelvic CT scan—with MPR, MIP, and VR reconstruction—before emptying the bladder. Since...

  18. Fully Automated Prostate Magnetic Resonance Imaging and Transrectal Ultrasound Fusion via a Probabilistic Registration Metric

    OpenAIRE

    Sparks, Rachel; Bloch, B. Nicolas; Feleppa, Ernest; Barratt, Dean; Madabhushi, Anant

    2013-01-01

    In this work, we present a novel, automated, registration method to fuse magnetic resonance imaging (MRI) and transrectal ultrasound (TRUS) images of the prostate. Our methodology consists of: (1) delineating the prostate on MRI, (2) building a probabilistic model of prostate location on TRUS, and (3) aligning the MRI prostate segmentation to the TRUS probabilistic model. TRUS-guided needle biopsy is the current gold standard for prostate cancer (CaP) diagnosis. Up to 40% of CaP lesions appea...

  19. Midline Cysts in the Prostate: Incidence in Healthy Men on Transrectal Ultrasonography (TRUS)

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Eun Kyoung; Lee, Yong Seok [Dongguk University Il-san Hospital, Goyang (Korea, Republic of); Kim, Sun Ho [National Cancer Center, Goyang (Korea, Republic of)

    2011-12-15

    To describe the incidence of prostatic midline cysts in healthy men on transrectal ultrasonography. From 2005 to 2009, 1,175 transrectal ultrasonography examinations were performed on 1,086 men (22-85 years) in a health promotion center. Incidence and size of midline cysts in men without any symptoms in the genitourinary tract were investigated according to age, prostate volume, and other ultrasonography findings. The incidence of midline cysts in healthy men was 28% (280/999). The mean diameter of midline cysts was 7.2 mm (1-30 mm). The incidence was the highest (32/102; 31.4%) and the size was the smallest (6.2 mm in mean) in men older than 60 years. The incidence of midline cysts in prostates larger than 20 ml was 33.2% (157/473) and in prostates smaller than or equal to 20 ml was 23.4% (123/526) (p < 0.05). Abnormal ultrasonography findings other than midline cysts were found in 196 men, and the incidence of midline cysts was high with seminal vesicle abnormalities (5/11: 45.5%). The incidence of prostatic midline cysts in healthy men on transrectal ultrasonography is higher than the result of previous studies. The incidence is higher in an enlarged prostate than in a prostate of normal size

  20. Analysis of Preoperative Detection for Apex Prostate Cancer by Transrectal Biopsy

    Directory of Open Access Journals (Sweden)

    Tomokazu Sazuka

    2013-01-01

    Full Text Available Background. The aim of this study was to determine concordance rates for prostatectomy specimens and transrectal needle biopsy samples in various areas of the prostate in order to assess diagnostic accuracy of the transrectal biopsy approach, especially for presurgical detection of cancer in the prostatic apex. Materials and Methods. From 2006 to 2011, 158 patients whose radical prostatectomy specimens had been evaluated were retrospectively enrolled in this study. Concordance rates for histopathology results of prostatectomy specimens and needle biopsy samples were evaluated in 8 prostatic sections (apex, middle, base, and transitional zones bilaterally from 73 patients diagnosed at this institution, besides factors for detecting apex cancer in total 118 true positive and false negative apex cancers. Results. Prostate cancer was found most frequently (85% in the apex of all patients. Of 584 histopathology sections, 153 (49% from all areas were false negatives, as were 45% of apex biopsy samples. No readily available preoperative factors for detecting apex cancer were identified. Conclusions. In Japanese patients, the most frequent location of prostate cancer is in the apex. There is a high false negative rate for transrectal biopsy samples. To improve the detection rate, transperitoneal biopsy or more accurate imaging technology is needed.

  1. Effect on hemostasis of an absorbable hemostatic gelatin sponge after transrectal prostate needle biopsy

    Directory of Open Access Journals (Sweden)

    Kohei Kobatake

    2015-04-01

    Full Text Available Objectives To examine the usefulness of an absorbable hemostatic gelatin sponge for hemostasis after transrectal prostate needle biopsy. Subjects and Methods The subjects comprised 278 participants who underwent transrectal prostate needle biopsy. They were randomly allocated to the gelatin sponge insertion group (group A: 148 participants and to the non-insertion group (group B: 130 participants. In group A, the gelatin sponge was inserted into the rectum immediately after biopsy. A biopsy-induced hemorrhage was defined as a case in which a subject complained of bleeding from the rectum, and excretion of blood clots was confirmed. A blood test was performed before and after biopsy, and a questionnaire survey was given after the biopsy. Results Significantly fewer participants in group A required hemostasis after biopsy compared to group B (3 (2.0% vs. 11 (8.5%, P=0.029. The results of the blood tests and the responses from the questionnaire did not differ significantly between the two groups. In multivariate analysis, only “insertion of a gelatin sponge into the rectum” emerged as a significant predictor of hemostasis. Conclusion Insertion of a gelatin sponge into the rectum after transrectal prostate needle biopsy significantly increases hemostasis without increasing patient symptoms, such as pain and a sense of discomfort.

  2. Caracterización de los tumores testiculares de células germinales según biopsias del servicio de patología. Hospital México, Costa Rica: enero 2003 a marzo 2011

    Directory of Open Access Journals (Sweden)

    Julia Freer-Vargas

    2013-03-01

    Full Text Available Justificación y objetivo: el 95% de los tumores testiculares son de células germinales. La presencia de estas neoplasias ha venido en aumento, y se han hecho más frecuentes en gente jóven. Los tumores testiculares de células germinales se dividen en dos grupos: seminomatosos y no seminomatosos. El objetivo fue caracterizar los con base en los resultados de biopsia del Patología del Hospital México, del 1º de enero del 2003, al 31 de marzo del 2011. Métodos: estudio descriptivo de una base de datos del servicio de Patología, en donde se seleccionaron los tumores testiculares de células germinales. En el análisis, se calcularon frecuencias absolutas, relativas, intervalos de confianza, medidas de dispersión y de tendencia central y Chi cuadrado p< 0,05 para la tendencia. Resultados: se seleccionaron 148 casos con neoplasias de células germinales. Existe tendencia del aumento en los tumores con p < 0.003. El 60.2% (89 casos; IC 95% 52.2-68.1, se presentó en menores de 30 años. Los tumores testiculares de células germinales no seminomatosos se presentaron en un 59.5% (88 casos, IC 95% (51.5-67.3; el promedio de edad para los no seminomatosos fue de 26.4 años, DE 8.1; y para los seminomatosos fue de 31 años, DE 7.5, con una diferencia calculada de p<0.001. Conclusiones: existe una tendencia significativa al aumento de los tumores testiculares de células germinales, que es más frecuente en menores de 30 años. Los tumores testiculares de células germinales no seminomatosos son los más frecuentes, cuyo promedio de edad es significativamente menor, que el de los TTCG seminomatosos. Se recomienda dirigir campañas de detección a población en riesgo y ampliar el estudio a otros hospitales.

  3. Descripción de los casos de nefropatía lúpica diagnosticados por biopsia en el Hospital Universitario del Valle, Cali, 1995-2000.

    OpenAIRE

    Rodrigo Villalobos; Pedro Rovetto; Armando Cortés; Consuelo Restrepo de Rovetto

    2009-01-01

    Se presenta un estudio descriptivo retrospectivo de 51 casos informados de nefropatía lúpica en el Departamento de Patología del Hospital Universitario del Valle, Cali, entre los años 1995 y 2000. Los casos fueron descritos según variables generales como sexo y grupo de edad al momento de la biopsia, diagnóstico histológico, grado de la nefropatía lúpica y puntajes del índice de actividad y cronicidad, según las definiciones aceptadas internacionalmente. Se hicieron comparaciones para determi...

  4. Factores predictivos de nefropatía no diabética en pacientes diabéticos. Utilidad de la biopsia renal

    OpenAIRE

    Bermejo García, Sheila; Soler, María José; Gimeno Beltran, Javier; Barrios Barrera, Clara; Rodríguez, Eva; Mojal, Sergio; Pascual Santos, Julio

    2016-01-01

    Antecedentes y objetivos: La afectación renal del diabético solo puede determinarse mediante biopsia renal, que presenta una elevada prevalencia de lesiones no diabéticas. Los objetivos del estudio fueron determinar la predictibilidad de nefropatía no diabética (NND) en diabéticos, estudiar diferencias de supervivencia y pronóstico renal, evaluar las lesiones histológicas en nefropatía diabética (ND) y el efecto de la proteinuria en la supervivencia y pronóstico renal en esta población. Mater...

  5. Biopsia por congelación para diagnóstico de infección en revisión de reemplazo total de cadera

    OpenAIRE

    Correcha Urazán, Johan; Franco Torres, Hernando; Rincón Hoyos, Jairo; Manrique, Jorge

    2007-01-01

    En estados unidos se realizaron 200.000 reemplazos de cadera en el 2001, de los cuales 36.000 fueron cirugías de revisión. La incidencia de infección en primarios es del 1% mientras que en revisión es 4% . Es determinante detectar la presencia o no de infección, sin embargo no existe una prueba 100% sensible ni 100% especifica. El cultivo intraoperatorio es el patrón de oro, pero inoportuno para tomar decisiones intraoperatorias. La biopsia por congelación es un estudio histopatológico que ay...

  6. Clinically low-risk prostate cancer: evaluation with transrectal doppler ultrasound and functional magnetic resonance imaging

    Directory of Open Access Journals (Sweden)

    Maria Inês Novis

    2011-01-01

    Full Text Available OBJECTIVES: To evaluate transrectal ultrasound, amplitude Doppler ultrasound, conventional T2-weighted magnetic resonance imaging, spectroscopy and dynamic contrast-enhanced magnetic resonance imaging in localizing and locally staging low-risk prostate cancer. INTRODUCTION: Prostate cancer has been diagnosed at earlier stages and the most accepted classification for low-risk prostate cancer is based on clinical stage T1c or T2a, Gleason score <6, and prostate-specific antigen (PSA <10 ng/ml. METHODS: From 2005 to 2006, magnetic resonance imaging was performed in 42 patients, and transrectal ultrasound in 26 of these patients. Seven patients were excluded from the study. Mean patient age was 64.94 years and mean serum PSA was 6.05 ng/ml. The examinations were analyzed for tumor identification and location in prostate sextants, detection of extracapsular extension, and seminal vesicle invasion, using surgical pathology findings as the gold standard. RESULTS: Sixteen patients (45.7% had pathologically proven organ-confined disease, 11 (31.4% had positive surgical margin, 8 (28.9% had extracapsular extension, and 3 (8.6% presented with extracapsular extension and seminal vesicle invasion. Sensitivity, specificity, positive predictive value (PPV, negative predictive value (NPV and accuracy values for localizing low-risk prostate cancer were 53.1%, 48.3%, 63.4%, 37.8% and 51.3% for transrectal ultrasound; 70.4%, 36.2%, 65.1%, 42.0% and 57.7% for amplitude Doppler ultrasound; 71.5%, 58.9%, 76.6%, 52.4% and 67.1% for magnetic resonance imaging; 70.4%, 58.7%, 78.4%, 48.2% and 66.7% for magnetic resonance spectroscopy; 67.2%, 65.7%, 79.3%, 50.6% and 66.7% for dynamic contrast-enhanced magnetic resonance imaging, respectively. Sensitivity, specificity, PPV, NPV and accuracy values for detecting extracapsular extension were 33.3%, 92%, 14.3%, 97.2% and 89.7% for transrectal ultrasound and 50.0%, 77.6%, 13.7%, 95.6% and 75.7% for magnetic resonance imaging

  7. Chorion biopsy in mongrel dogs Biopsia do cório fetal em cães

    Directory of Open Access Journals (Sweden)

    Guilherme J. Ferreira

    2009-10-01

    Full Text Available With the great development of the gestational studies in all of the species, we noticed the necessity of adaptations of these techniques for prenatal diagnosis in dogs. Based on this, we studied the feasibility of chorion biopsy guided by ultrasound. Our results demonstrated accuracy on the sex determination being 2 males and 12 females, as well as it would be possible to identify chromosome alteration due to the quality of samplings. Sex determination was accomplished with the identification of Y gene chromosomes in PCR technique. After the collection, fragments were prepared for light microscopy studies and revealed fetal chorion tissue, blood colloid and erythrocyte. In the whole material we found hemosiderin impregnations due to the hemolysis and to the residue of blood of the placental marginal hematomes. The submitted female dogs to this technique demonstrated normal puppy births without death.Com o grande desenvolvimento dos estudos gestacionais em todas as espécies, percebemos a necessidade de adaptarmos técnicas para diagnóstico pré-natal para cães. Assim, buscamos bases nas técnicas já existentes empregadas em humanos, e através destas, conseguimos estabelecer um método para coleta em cães, utilizando PCR para garantirmos a integridade das amostras. O procedimento foi realizado através de punção da cinta placentária com agulha de biopsia guiada por ultra-som. De todas as 14 amostras coletadas, duas apresentaram-se positivas para o cromossomo Y, presente apenas em machos, confirmando assim a viabilidade das amostras demonstrando com isso que através desta técnica podemos coletar material fetal para diagnóstico de alterações gênicas ou cromossômicas presentes nos cães antes mesmo destes virem a termo. A microscopia de material revelou fragmentos de cório fetal, colóide sangüíneo e eritrócitos. Em todo o material encontramos impregnações de hemosiderina devido à hemólise e ao resíduo de sangue dos hematomas

  8. ENFOQUE DIAGNÓSTICO EN EL PACIENTE CON DERRAME PLEURAL

    Directory of Open Access Journals (Sweden)

    Maite Oyonarte W., DRA.

    2015-05-01

    Full Text Available En el estudio diagnóstico del paciente con derrame pleural se deben considerar la historia clínica y el análisis de las imágenes para acotar el diagnóstico diferencial. El uso adecuado de las técnicas de imágenes contribuye a realizar procedimientos en forma segura. Se debe realizar una toracocentesis diagnóstica y/o evacuadora y se debe analizar completamente el líquido pleural. A veces es necesario realizar biopsia pleural para lo cual existen diversas técnicas disponibles. En los pacientes con pleuritis crónica inespecífica se debe hacer seguimiento por dos años para evaluar el desarrollo de malignidad.

  9. Osteosarcoma de huesos del pie con alto grado de malignidad

    OpenAIRE

    Alain Martínez Milián; Rafael Ramírez Bichilik

    2015-01-01

    El osteosarcoma es la neoplasia primaria del hueso más frecuente, los hombres son los más afectados en una relación 1,2 - 1,5 por cada mujer y con una tasa de mortalidad cercana a 0,15/100.000 habitantes/año. Se reporta el caso de una paciente femenina de 57 años de edad, con dolor, aumento de volumen e impotencia funcional de aproximadamente seis meses de evolución, los exámenes diagnósticos utilizados fueron radiografía de pie, tomografía axial computarizada de miembro inferior y biopsia de...

  10. La biopsia con aguja gruesa guiada mediante estereotaxia en el diagnóstico de las lesiones mamarias sospechosas de malignidad

    OpenAIRE

    Hidalgo Pérez, José Alberto

    2000-01-01

    Consultable des del TDX Títol obtingut de la portada digitalitzada El cáncer de mama es una enfermedad en la que no es posible la prevención primaria por lo que para disminuir la morbimortalidad es imprescindible un diagnóstico precoz que permita un tratamiento efectivo. Dado que en las campañas de cribado y en las mamografías de control se diagnostican muchas lesiones de las que no es posible saber si se trata o no de lesiones malignas hasta que no se biopsian, son necesarias técnicas ...

  11. BACILOS ÁCIDO ALCOHOLRESISTENTES EN BIOPSIAS EMBEBIDASEN PARAFINA EN CASOS DE INFLAMACIÓNGRANULOMATOSA CRÓNICA. Detection of Acid-Fast Bacilli in Formalin-Fixed,Paraffin-Embedded Tissues of Patientswith Chronic Granulomatous Inflammation.

    Directory of Open Access Journals (Sweden)

    JAVIER ANDRÉS BUSTAMANTE

    Full Text Available La detección de bacilos ácido alcohol resistentes (BAAR en frotis resulta un aporte significativo al diagnóstico y tratamiento de individuos con inflamación granulomatosa crónica (IGC. Con el objetivo de evaluar la presencia de BAAR en diferentes tejidos de pa-cientes con IGC demostrada y comparar la frecuencia de los extendidos positivos para BAAR con el grado de formación de granulomas y necrosis, se diseño un estudio retrospectivo, en el que se seleccionaron 57 bloques embebidos en parafina que contenían biopsias de pleura, pulmón, pericardio, ganglio linfático y lóbulo cerebral, correspon-dientes a 30 pacientes (63,3% hombres, mayores de 18 años, con IGC demostrada y remitidos al departamento de patología del Hospital Universitario del Valle entre el 2002-2008. A cada muestra se le realizaron tres cortes y se sometieron a tinciones de H/E, Zielh Neelsen y Auramina. La detección de BAAR en frotis fue similar para ambas tinciones especiales en pacientes con IGC necrotizante, reflejando una excelente concordancia en el diagnóstico (kappa=0,89, IC95%(0,68-1,0. Sin embargo, la tinción con Auramina fue superior a la tinción Ziehl Neelsen para la detección de BAAR en pacientes con IGC no necrotizante (kappa=0,65, IC95%(0,23-1,0. No se encontraron diferencias signi-ficativas entre la presencia de BAAR y el tipo de inflamacion, sexo y localización anatómica comprometida. En general, fue buena la concordancia entre los métodos histológicos empleados. Además, se hizo evidente la importancia de implementar el uso de técnicas moleculares mínimamente afectadas por el escaso número de bacilos presentes en las muestras, que finalmente ayudan en el reconocimiento del microorganismo.Detection of acid fast bacilli (AFB in smears is a significant aid in diagnosis and treatment of individuals with chronic granulomatous inflammation (CGI. This study was designed in order to detect the presence of AFB in several tissues of patients with

  12. VASCULITIS DE CHURG-STRAUSS: PRESENTACIÓN CLÍNICA COMO GLOMERULONEFRITIS EXTRACAPILAR NECROTIZANTE PAUCI-INMUNE CON NEFRITIS TUBULO-INTERSTICIAL EOSINOFÍLICA.

    OpenAIRE

    Fernanda da Cunha; Edgar Lorga; Tânia Sousa; Jesús Garrido.

    2004-01-01

    RESUMEN: Se presenta el caso clínico de una mujer de 81 años con antecedentes patología pulmonar obstructiva crónica "idiopática" que desarrolló un cuadro de insuficiencia renal aguda aparentemente prerrenal, con posterior oliguria y eosinofilia simulando una nefropatía túbulo-intersticial alérgica. La evolución atípica y la presencia de p-ANCA, sugerían una vasculitis, patología que se confirmó con la biopsia renal. Los resultados anatomopatológicos revelaron la existencia de una glomerulone...

  13. Tumor de Pindborg relacionado con trauma facial

    Directory of Open Access Journals (Sweden)

    Niorgy Rodríguez Rodríguez

    2011-12-01

    Full Text Available El tumor de Pindborg es una neoplasia benigna, rara, con carácter invasivo local y tendencia a la recidiva, que representa entre el 0,17 y el 1,8 % de todos los tumores odontogénicos, del cual tan solo se han publicado unos 200 casos, con una media de 4 casos nuevos por año en el mundo. Se presentó el caso de un hombre de 39 años de edad que acudió a la consulta de cirugía maxilofacial remitido de neurocirugía postraumatismo craneofacial, por presentar un aumento de volumen en el ángulo mandibular derecho. Se tuvo como objetivo publicar la existencia de esta infrecuente neoplasia por lo interesantes que resultan estos tumores por su evolución, dificultad en el diagnóstico, variantes de tratamiento y tendencia a la recidiva. Después de realizar exámenes de laboratorio, radiografías, tomografía axial computarizada y biopsia de fragmento óseo, se obtuvo extensión y diagnóstico de tumor de Pindborg en hemimandíbula derecha. Se realizó la técnica quirúrgica de hemimandibulectomía derecha y reconstrucción con injerto óseo de cresta ilíaca. La evolución del paciente fue satisfactoria.

  14. Utilidad de la elastografía de transición (Fibroscan® en la evaluación de la fibrosis hepática en pacientes con hepatopatía crónica

    Directory of Open Access Journals (Sweden)

    Daniel Álvarez

    2012-02-01

    Full Text Available El pronóstico de la enfermedad crónica hepática depende de la extensión y la progresión de la fibrosis hepática. Actualmente la biopsia hepática es la técnica de elección para determinar el grado de fibrosis, pero es una prueba invasiva, no exenta de complicaciones. Por ello, el desarrollo de marcadores no invasivos de fibrosis hepática se convirtió en una necesidad indiscutible. Se propuso la elastografìa por transición (Fibroscan® para valorar la fibrosis hepática en pacientes con enfermedad crónica hepática, mediante la medición de la rigidez hepática. Nuestro objetivo fue evaluar la efectividad, la objetividad y la seguridad de esta técnica. Se estudiaron 68 pacientes a los que se les realizó una biopsia hepática en los 18 meses previos al estudio. Todos los procedimientos de elastografia y biopsia hepática fueron analizados por un mismo profesional (DA y MA, respectivamente. Para la valoración de la biopsia hepática se utilizó la escala METAVIR. El valor medio de rigidez en pacientes sin fibrosis o con fibrosis leve (F0-F1 y en los pacientes con fibrosis avanzada o cirrosis (F3-F4 fue 6.8 ± 3.0 kPa y 21.0 ± 15.1 kPa, respectivamente (con diferencia significativa, p < 0.01. Las áreas debajo de la curva ROC definieron los niveles de corte en cada grupo. Con independencia del diagnóstico etiológico de enfermedad hepática, hallamos una correlación positiva, en todos los pacientes, entre rigidez hepática medida por elastografìa y grado de fibrosis hepática en la biopsia. En conclusión, podemos considerar que el Fibroscan® es un método no invasivo, seguro, fácil y rápido, que lo convierte en la alternativa a la biopsia para identificar fibrosis significativa o cirrosis.

  15. Assessment and clinical factors associated with pain in patients undergoing transrectal prostate biopsy.

    Science.gov (United States)

    Gómez-Gómez, E; Ramírez, M; Gómez-Ferrer, A; Rubio-Briones, J; Iborra, I; J Carrasco-Valiente; Campos, J P; Ruiz-García, J; Requena-Tapia, M J; Solsona, E

    2015-09-01

    To quantify the degree of pain experienced by patients who undergo ultrasound-guided transrectal prostate biopsy in standard clinical practice and assess the clinical factors associated with increased pain. Analysis of a multicenter series of patients with prostate biopsy according to standard clinical practice. The biopsy was performed transrectally with a protocol of local anesthesia on the posterolateral nerve bundle. The pain was assessed at 20minutes into the procedure using the visual analog scale (0-10). The degree of pain was analyzed, and the association was studied using a univariate/multivariate analysis of selected clinical variables and the degree of pain. A total of 1188 patients with a median age of 64 years were analyzed. Thirty percent of the biopsies were diagnosed with a tumor. The median pain score was 2, with 65% of the patients reporting a pain score ≤2. The multivariate analysis showed that the prostate volume (RR, 1.34; 95% CI 1.01-1.77; P=.04), having a previous biopsy (RR, 2.25; 95% CI 1.44-3.52; P<.01), age (RR, .63; 95% CI .47-.85; P<.01) and feel palpation (RR, 1.95; 95% CI 1.28-2.96; P<.01) were factors independently associated with greater pain during the procedure. Transrectal biopsy with local anesthesia is a relatively painless technique. Factors such as age, a previous biopsy, pain on being touched and prostate volume were associated with the presence of greater pain during the procedure. Copyright © 2014 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.

  16. Targeted histology sampling from atypical small acinar proliferation area detected by repeat transrectal prostate biopsy

    Directory of Open Access Journals (Sweden)

    A. V. Karman

    2017-01-01

    Full Text Available Оbjective: to define the approach to the management of patients with the detected ASAP area.Materials and methods. In the time period from 2012 through 2015, 494 patients with previously negative biopsy and remaining suspicion of prostate cancer (PCa were examined. The patients underwent repeat 24-core multifocal prostate biopsy with taking additional tissue samples from suspicious areas detected by multiparametric magnetic resonance imaging and transrectal ultrasound. An isolated ASAP area was found in 127 (25. 7 % of the 494 examined men. All of them were offered to perform repeat target transrectal biopsy of this area. Targeted transrectal ultrasound guided biopsy of the ASAP area was performed in 56 (44.1 % of the 127 patients, 53 of them being included in the final analysis.Results. PCa was diagnosed in 14 (26.4 % of the 53 patients, their mean age being 64.4 ± 6.9 years. The average level of prostate-specific antigen (PSA in PCa patients was 6.8 ± 3.0 ng/ml, in those with benign lesions – 9.3 ± 6.5 ng/ml; the percentage ratio of free/total PSA with PCa was 16.2 ± 7,8 %, with benign lesions – 23.3 ± 7.7 %; PSA density in PCa patients was 0.14 ± 0.07 ng/ml/cm3, in those with benign lesions – 0.15 ± 0.12 ng/ml/cm3. Therefore, with ASAP area being detected in repeat prostate biopsy samples, it is advisable that targeted extended biopsy of this area be performed. 

  17. Feasibility of a 2(nd) generation MR-compatible manipulator for transrectal prostate biopsy guidance.

    Science.gov (United States)

    Bomers, J G R; Bosboom, D G H; Tigelaar, G H; Sabisch, J; Fütterer, J J; Yakar, D

    2017-04-01

    To assess the feasibility of a 2(nd) generation MR-compatible, remote-controlled manipulator (RCM) as an aid to perform MR-guided transrectal prostate biopsy in males with suspicion of prostate cancer (PCa). This prospective phase I study was approved by the local ethical committee and written informed consent was obtained from each patient. Twenty patients with ≥1 cancer suspicious region (CSR) with a PI-RADS score of ≥3 detected on the diagnostic multi-parametric MRI and no prior prostate treatment underwent MR-guided biopsy with the aid of the RCM. Complications were classified according to the modified Clavien system for reporting surgical complications. For evaluation of the workflow, procedure- and manipulation times were recorded. All CSR's (n=20) were reachable with the MR-compatible RCM and the cancer detection rate was 70 %. The median procedure time was 36:44 minutes (range, 23 - 61 minutes) and the median manipulation time for needle guide movement was 5:48 minutes (range, 1:15 - 18:35 minutes). Two Clavien grade 1 complications were reported. It is feasible and safe to perform transrectal MR-guided prostate biopsy using a MR-compatible RCM as an aid. It is a fast and efficient way to biopsy suspicious prostate lesions with a minimum number of biopsies per patient. • It is feasible to perform transrectal prostate biopsy using a MR-compatible RCM. • Using a RCM for MR-guided biopsy is safe, fast, and efficient. • All cancer suspicious regions were reachable with the RCM.

  18. Mucormicosis yeyunal en paciente con linfoma de Hodgkin Jejunal mucormycosis in a patient with Hodgkin's lymphoma

    OpenAIRE

    B. Madrigal; J. J. Arenal; Torres, A.; M. J. Peñarrubia; A. Vara; Ruiz, M.; Hernández, A.; P. Enríquez

    2008-01-01

    Comunicamos un caso de mucormicosis intestinal en un hombre de 46 años de edad, diagnosticado de enfermedad de Hodgkin clásica, estadio IV-B. Durante la primera fase de la quimioterapia, sufrió una hemorragia digestiva masiva secundaria a una úlcera yeyunal por zigomicosis tipo mucor, diagnosticada por biopsia endoscópica. El paciente fue tratado con antifúngicos y resección quirúrgica del intestino afectado. En la cirugía, se apreció una doble perforación yeyunal cubierta. El estudio anatomo...

  19. Transrectal EUS-guided FNA biopsy of a presacral chordoma-report of a case and review of the literature

    Institute of Scientific and Technical Information of China (English)

    Klaus Gottlieb; Paul H Lin; David M Liu; Karl Anders

    2008-01-01

    Chordomas are rare tumors which originate from the remnants of the notochord.These tumors are locally aggressive and have a predilection for the ends of the axial skeleton.An important prerequisite for optimal management of these tumors is a correct preoperative diagnosis.The present case is the first report of the use of endoscopic ultrasound to obtain transrectal fine needle aspiration biopsy of a presacral chordoma.A review of the prior computer tomography (CT) scans allowed us to calculate the tumor volume doubling time (18.3 mo).Transrectal biopsy of chordomas is controversial,however we believe that such concerns are not justified.

  20. Tamoxifeno y afecciones endometriales en pacientes con cáncer de mama

    Directory of Open Access Journals (Sweden)

    Delia B. Dalbert

    2013-04-01

    Full Text Available Los objetivos fueron evaluar la prevalencia de afecciones endometriales en pacientes tratadas con tamoxifeno (TAM y analizar los aspectos epidemiológicos, ecográficos, histeroscópicos e histopatológicos. Desde enero de 1999 a diciembre 2008 se estudiaron 152 pacientes con cáncer de mama tratadas con TAM (20 mg/día, sintomáticas (con sangrado o asintomáticas, pre y postmenopáusicas, incluidas en forma consecutiva. El diseño fue prospectivo y observacional. Los métodos diagnósticos usados fueron ecografía transvaginal, histeroscopía y biopsia. Las pacientes fueron seguidas durante 5 años con ecografía cada 12 meses e histeroscopia con biopsia en casos que lo justificaran. Edad: 62.76 ± 10.24 años y tiempo de tratamiento: 36.2 ± 19.9 meses. El adenocarcinoma se observó en 3/87 (3.45% pacientes con factores de riesgo y en 1/65 (1.54% sin ellos (RA: 1.91, IC 95% 1.88 a 1.94. Las afecciones benignas se hallaron en 148 pacientes (97.37% y los adenocarcinomas en 4 (2.63%,1 en un pólipo de aspecto benigno. Los 4 se observaron en mujeres postmenopáusicas (2 asintomáticas con grosor endometrial igual o mayor a 16 mm. El riesgo de cáncer fue significativamente mayor en sintomáticas (2.36 versus 0.42 en asintomáticas. Tres adenocarcinomas se detectaron entre 24 y 48 meses del tratamiento. Recomendamos un seguimiento con ecografía transvaginal de las pacientes asintomáticas, resección de los pólipos evaluando factores de riesgo y tiempo de exposición, en especial luego de los 24 meses. Consideramos aceptable un cut-off = 10 mm en el grosor del endometrio en postmenopáusicas asintomáticas para realizar histeroscopía y biopsia.

  1. Feasibility of a 2{sup nd} generation MR-compatible manipulator for transrectal prostate biopsy guidance

    Energy Technology Data Exchange (ETDEWEB)

    Bomers, J.G.R.; Yakar, D. [Radboud University Nijmegen Medical Center, Department of Radiology, route 766, P.O Box 9101, Nijmegen (Netherlands); Bosboom, D.G.H. [Radboud University Nijmegen Medical Center, Department of Radiology, route 766, P.O Box 9101, Nijmegen (Netherlands); Soteria Medical, Arnhem (Netherlands); Tigelaar, G.H.; Sabisch, J. [Soteria Medical, Arnhem (Netherlands); Fuetterer, J.J. [Radboud University Nijmegen Medical Center, Department of Radiology, route 766, P.O Box 9101, Nijmegen (Netherlands); University of Twente, MIRA Institute for Biomedical Technology and Technical Medicine, Enschede (Netherlands)

    2017-04-15

    To assess the feasibility of a 2{sup nd} generation MR-compatible, remote-controlled manipulator (RCM) as an aid to perform MR-guided transrectal prostate biopsy in males with suspicion of prostate cancer (PCa). This prospective phase I study was approved by the local ethical committee and written informed consent was obtained from each patient. Twenty patients with ≥1 cancer suspicious region (CSR) with a PI-RADS score of ≥3 detected on the diagnostic multi-parametric MRI and no prior prostate treatment underwent MR-guided biopsy with the aid of the RCM. Complications were classified according to the modified Clavien system for reporting surgical complications. For evaluation of the workflow, procedure- and manipulation times were recorded. All CSR's (n=20) were reachable with the MR-compatible RCM and the cancer detection rate was 70 %. The median procedure time was 36:44 minutes (range, 23 - 61 minutes) and the median manipulation time for needle guide movement was 5:48 minutes (range, 1:15 - 18:35 minutes). Two Clavien grade 1 complications were reported. It is feasible and safe to perform transrectal MR-guided prostate biopsy using a MR-compatible RCM as an aid. It is a fast and efficient way to biopsy suspicious prostate lesions with a minimum number of biopsies per patient. (orig.)

  2. Transrectal Ultrasound Guided Biopsy of the Prostate: Is the Information Accessible, Usable, Reliable and Readable?

    Science.gov (United States)

    Redmond, Ciaran E.; Nason, Gregory J.; Kelly, Michael E.; McMahon, Colm; Cantwell, Colin P.; Quinlan, David M.

    2015-01-01

    Background/Aims To evaluate the accessibility, usability, reliability and readability of Internet information regarding transrectal ultrasound (TRUS) guided biopsy of the prostate. Materials and Methods The terms “prostate biopsy”, “TRUS biopsy” and “transrectal ultrasound guided biopsy of the prostate” were separately entered into the each of the top 5 most accessed Internet search engines. Websites were evaluated for accessibility, usability and reliability using the LIDA tool – a validated tool for the assessment of health related websites. Website readability was assessed using the Flesch Reading Ease Score and the Flesch Kincaid Grade Level. Results Following the application of exclusion criteria, 82 unique websites were analyzed. There was a significant difference in scores depending on authorship categories (p ≤ 0.001), with health related charity websites scoring highest (mean 122.29 ± 13.98) and non-academic affiliated institution websites scoring lowest (mean 87 ± 19.76). The presence of advertisements on a website was associated with a lower mean overall LIDA tool score (p = 0.024). Only a single website adhered to the National Institutes for Health recommendations on readability. Conclusions This study demonstrates variability in the quality of information available to Internet users regarding TRUS biopsies. Collaboration of website design and clinical acumen are necessary to develop appropriate websites for patient benefit. PMID:26195961

  3. Digital rectal examination and transrectal ultrasonography in staging of rectal cancer

    DEFF Research Database (Denmark)

    Rafaelsen, Søren Rafael; Kronborg, Ole; Fenger, Claus

    1994-01-01

    Staging of rectal carcinoma before surgical treatment was performed in a prospective blind study, comparing digital rectal exploration and transrectal linear ultrasonography (TRUS) with the resulting pathological examination. TRUS underestimated depth of penetration in 3 of 33 patients and overes......Staging of rectal carcinoma before surgical treatment was performed in a prospective blind study, comparing digital rectal exploration and transrectal linear ultrasonography (TRUS) with the resulting pathological examination. TRUS underestimated depth of penetration in 3 of 33 patients...... and overestimation resulted in 9 of 74. The figures for digital examination were 5 of 18 and 20 of 76, respectively. Penetration of the rectal wall was correctly identified in 56 of 61 patients by digital examination and in 59 of 61 by TRUS. Specimens without penetration of the rectal wall were identified in 26...... of 33 patients by TRUS, but in not more than 13 of 33 by digital examination. Regional lymph node metastases were present in 19 patients; none were diagnosed by digital examination, but TRUS identified 11 of the 19. It is concluded that TRUS will result in more patients having the possibility of local...

  4. Transrectal high-intensity focused ultrasound ablation of prostate cancer: Effective treatment requiring accurate imaging

    Energy Technology Data Exchange (ETDEWEB)

    Rouviere, Olivier [Hospices Civils de Lyon, Department of Urinary and Vascular Radiology, Pavillon P Radio, Hopital Edouard Herriot, F-69437 Lyon cedex 03 (France); Universite de Lyon, Lyon F-69003 (France); Universite de Lyon 1, Faculte de Medecine Lyon Nord, Lyon F-69003 (France); INSERM, Unit 556, 151 cours Albert Thomas, F-69424 Lyon cedex 03 (France)], E-mail: Olivier.rouviere@netcourrier.com; Souchon, Remi [INSERM, Unit 556, 151 cours Albert Thomas, F-69424 Lyon cedex 03 (France)], E-mail: souchon@lyon.inserm.fr; Salomir, Rares [INSERM, Unit 556, 151 cours Albert Thomas, F-69424 Lyon cedex 03 (France)], E-mail: salomir@lyon.inserm.fr; Gelet, Albert [Hospices Civils de Lyon, Department of Urology, Pavillon P Radio, Hopital Edouard Herriot, F-69437 Lyon cedex 03 (France)], E-mail: Albert.gelet@chu-lyon.fr; Chapelon, Jean-Yves [INSERM, Unit 556, 151 cours Albert Thomas, F-69424 Lyon cedex 03 (France)], E-mail: chapelon@lyon.inserm.fr; Lyonnet, Denis [Hospices Civils de Lyon, Department of Urinary and Vascular Radiology, Pavillon P Radio, Hopital Edouard Herriot, F-69437 Lyon cedex 03 (France); Universite de Lyon, Lyon F-69003 (France); Universite de Lyon 1, Faculte de Medecine Lyon Nord, Lyon F-69003 (France); INSERM, Unit 556, 151 cours Albert Thomas, F-69424 Lyon cedex 03 (France)], E-mail: Denis.lyonnet@chu-lyon.fr

    2007-09-15

    Transrectal HIFU ablation has become a reasonable option for the treatment of localized prostate cancer in non-surgical patients, with 5-year disease-free survival similar to that of radiation therapy. It is also a promising salvage therapy of local recurrence after radiation therapy. These favourable results are partly due to recent improvements in prostate cancer imaging. However, further improvements are needed in patient selection, pre-operative localization of the tumor foci, assessment of the volume treated and early detection of recurrence. A better knowledge of the factors influencing the HIFU-induced tissue destruction and a better pre-operative assessment of them by imaging techniques should improve treatment outcome. Whereas prostate HIFU ablation is currently performed under transrectal ultrasound guidance, MR guidance with real-time operative monitoring of temperature will be available in the near future. If this technique will give better targeting and more uniform tissue destruction, its cost-effectiveness will have to be carefully evaluated. Finally, a recently reported synergistic effect between HIFU ablation and chemotherapy opens possibilities for treatment in high-risk or clinically advanced tumors.

  5. Value of three-section contrast-enhanced transrectal ultrasonography in the detection of prostate cancer.

    Science.gov (United States)

    Qi, Ting-Yue; Sun, Hong-Guang; Li, Nian-Fen; Feng, Hao; Ding, Yong-Ling; Wang, Xiao-Xiang

    2017-06-01

    To assess the efficacy of three-section contrast-enhanced transrectal ultrasonography (CETRUS) in prostate cancer (PCa) detection. A total of 169 consecutive patients with either PSA level ≥ 4 ng/ml or abnormal digital rectal examination findings were prospectively enrolled in this single center study. All patients underwent baseline transrectal ultrasonography (TRUS) and three-section CETRUS by one investigator blinded to any clinical data before TRUS-guided transperineal biopsy. The performances of baseline TRUS, single-section, and three-section CETRUS for PCa detection were compared. On a per-patient basis, the sensitivity, specificity, and overall accuracy for detecting PCa with three-section CETRUS was 92.3%, 69.2%, and 78.1%, respectively. In comparison with conventional (single-section) CETRUS (sensitivity 75.4%, specificity 72.1%, and accuracy 73.4%), three-section CETRUS performed significantly better (p section CETRUS was significantly higher than that of conventional CETRUS (26.7% versus 10.2%, p section CETRUS relative to conventional CETRUS, and this technique may find more PCa patients eligible for active surveillance. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound 45:304-309, 2017. © 2017 Wiley Periodicals, Inc.

  6. [Use of intrarectal lidocaine gel in ultrasound-guided transrectal biopsies of the prostate].

    Science.gov (United States)

    García Mediero, J M; Martínez-Piñeiro Lorenzo, L; Núñez Mora, C; de Fata Chillón, F Ramón; Cruz Jimeno, J L; Alonso y Gregorio, S; de la Peña Barthel, J J

    2003-01-01

    To know in a quantitative manner the degree of discomfort and pain of the biopsies of the prostate and to evaluate the effectiveness of the transrectal lidocaine. We performed 140 transrectal biopsies of the prostate, Patients were included on a random basis into two arms: one of them received intrarectal lidocaine, 20 mg (group 1, n = 71) and the other group received placebo (group 2, n = 28) both of them ten minutes prior the proceeding. The global pain mean was 3.7 (0 no pain, 10 highest pain) and the global discomfort mean was 3.5. The group 1 patients showed a trend to feel less pain and discomfort although it did not reach the necessary statistic significance (p = 0.7 y p = 0.5 respectively). We do not achieve the good results obtained by other groups in order to decrease the degree of pain and discomfort with the use of intrarectal lidocaine. We did not find relationship between the PSA level, previous biopsies, intrarectal lidocaina and degree of information received and the degree of pain and discomfort.

  7. Avaliações ultra-sonográfica, macroscópica e histológica da biopsia testicular em ovinos Assessment of ultrasonographic images and gross and microscopic lesions of the testicular biopsy in sheep

    Directory of Open Access Journals (Sweden)

    R. Sartori

    2002-06-01

    Full Text Available Devido ao fato da biopsia testicular poder acarretar hemorragia, inflamação, degeneração, aderência e fibrose, especialmente com as técnicas incisionais ou abertas, este trabalho avaliou a aplicabilidade de uma técnica menos invasiva (biopsia com agulha Tru-Cut em ovinos na obtenção de material para histologia e acompanhou as lesões testiculares posteriores. Trinta carneiros foram igualmente divididos em três grupos: 1 controle, animais não submetidos à biopsia; 2 submetidos à biopsia + cola de fibrina nos locais da biopsia testicular e incisões da pele; e 3 submetidos à biopsia + sutura da pele escrotal após a biopsia. Exames ultra-sonográficos foram realizados pré e pós biopsia. No centésimodia, os testículos foram avaliados macro e microscopicamente após orquiectomia. A ultra-sonografia permitiu mapear as alterações ocorridas e acompanhar a evolução das seqüelas. Ao exame macroscópico, pequenas áreas de calcificação foram observadas em 55 e 70% dos testículos nos grupos 2 e 3, respectivamente. A biopsia com agulha Tru-Cut forneceu material suficiente para histologia mas ocasionou lesões focais restritas à área biopsiada. Apesar da possível ocorrência de calcificação e outras lesões mínimas, foi demonstrado que a biopsia com agulha Tru-Cut em ovinos é um procedimento seguro por não ter comprometido significativamente as características estruturais e funcionais dos testículos.Because testicular biopsy can cause hemorrhage, inflammation, degeneration, adhesion, and fibrosis, especially if using the incisional or open biopsy techniques, the present study evaluated if testicular biopsy with Tru-Cut needle (a less invasive technique in rams provides enough material for histology, and followed the subsequent testicular lesions. Thirty rams were evenly assigned to three groups: 1 control, no biopsy; 2 biopsy + fibrin glue on biopsy sites and skin incisions; and 3 biopsy + scrotal skin suture after biopsy

  8. Perfil bioquímico del músculo Gluteus medius enequinos con distinto historial en carreras de resistencia Biochemical profile of the Gluteus medius muscle in horses with different performance records

    OpenAIRE

    1998-01-01

    El objetivo del estudio fue examinar las actividades de enzimas representativasde rutas metabólicas importantes del músculo esqueléticoen equinos de resistencia con diferente historial en competiciones, conel objeto de explicar si estas diferencias contribuyen a las diferenciasobservadas en el rendimiento funcional. Se obtuvieron biopsias a tres profundidadesdistintas (20, 40, 60 mm) del músculo Gluteus medius en 36equinos participantes en carreras de larga distancia de nivel nacionale intern...

  9. High-dose-rate prostate brachytherapy based on registered transrectal ultrasound and in-room cone-beam CT images

    NARCIS (Netherlands)

    Even, Aniek J.G.; Nuver, Tonnis T.; Westendorp, Hendrik; Hoekstra, Carel J.; Slump, C.H.; Minken, Andre W.

    2014-01-01

    Purpose To present a high-dose-rate (HDR) brachytherapy procedure for prostate cancer using transrectal ultrasound (TRUS) to contour the regions of interest and registered in-room cone-beam CT (CBCT) images for needle reconstruction. To characterize the registration uncertainties between the two ima

  10. Utilización de análisis de imágenes para cuantificar células dendríticas S100 positivas en piel con lepra.

    OpenAIRE

    Luz H. Camargo; María Leonor Caldas; Marcela Neira; Ladys Sarmiento

    2003-01-01

    Se realizó un análisis morfométrico de células dendríticas de piel, que incluyó la determinación de la cantidad y el área ocupada, empleando un anticuerpo anti-S100 en biopsias de pacientes con diferentes tipos de lepra. El análisis reveló las diferencias entre los pacientes que presentaban una mejor respuesta inmune al bacilo, reflejada en una mayor cantidad de células dendríticas en los casos de lepra dimorfa tuberculoide y lepra tuberculoide con respecto a aquellos pacientes con lepra dimo...

  11. Colitis eosinofílica y colitis linfocítica: ¿diferentes manifestaciones histológicas de un mismo proceso en pacientes con diarrea crónica?

    OpenAIRE

    Arévalo, Fernando; Aragón, Violeta; Montes, Pedro; Perez Narrea, Teresa; Monge, Eduardo

    2014-01-01

    Objetivos: 1) Determinar la prevalencia de incremento de eosinófilos en mucosa colónica en pacientes con colitis linfocítica (CL). 2) Determinar la coexistencia de colitis eosinofílica (CE) en pacientes con CL. Materiales y métodos: Las biopsias colónicas de pacientes adultos con diarrea crónica diagnosticados como CL en el hospital Daniel A. Carrión durante octubre 2009 a marzo 2012 fueron revisadas de forma independiente por 2 patólogos. Microscópicamente, se investigó y cuantificó la prese...

  12. Biopsia y estudio anatomopatológico de una lesión quística de mucosa bucal

    OpenAIRE

    Santángelo, Georgina; Ricciardi, A.; Bogo, P.; Prada, G; Cacciola, S.; Celis, Z.; Di Franco, P.; Teixeira Pocas, M.; Lunaschi, A.

    2015-01-01

    Se presenta a la consulta un paciente de género femenino de 32 años de edad con una lesión única de tipo tumoral ubicada en la cara interna del labio inferior. Clínicamente la lesión se ve elevada, hemiesférica, de base amplia, indolora, de aproximadamente 15 mm de diámetro, cubierta de mucosa sana con características normales. A la palpación se revela blanda y fluctuante. El tiempo de evolución de la lesión es de aproximadamente 3 meses. Diagnóstico presuntivo: Quiste mucoide. Tratamiento: b...

  13. Towards 3D ultrasound image based soft tissue tracking: a transrectal ultrasound prostate image alignment system

    CERN Document Server

    Baumann, Michael; Daanen, Vincent; Troccaz, Jocelyne

    2007-01-01

    The emergence of real-time 3D ultrasound (US) makes it possible to consider image-based tracking of subcutaneous soft tissue targets for computer guided diagnosis and therapy. We propose a 3D transrectal US based tracking system for precise prostate biopsy sample localisation. The aim is to improve sample distribution, to enable targeting of unsampled regions for repeated biopsies, and to make post-interventional quality controls possible. Since the patient is not immobilized, since the prostate is mobile and due to the fact that probe movements are only constrained by the rectum during biopsy acquisition, the tracking system must be able to estimate rigid transformations that are beyond the capture range of common image similarity measures. We propose a fast and robust multi-resolution attribute-vector registration approach that combines global and local optimization methods to solve this problem. Global optimization is performed on a probe movement model that reduces the dimensionality of the search space a...

  14. Spondylodiscitis as Complication of Transrectal Ultrasonography-guided Prostate Biopsy: a Case Report

    Directory of Open Access Journals (Sweden)

    Liberato Aldo Ferrara

    2014-03-01

    Full Text Available A 61-year-old man presented with high fever, and severe back and abdominal pain following transrectal ultrasonography (TRUS-guided prostate biopsy. Diagnosis of spondylodiscitis and psoas abscesses was made based on MRI images of the lumbar tract of the spine. Six-month broad-spectrum antibiotic treatment and immobilization with a girdle overcame the disease without any relapse at the 1-year follow-up. Spondylodiscitis after TRUS-guided prostate biopsy is a rare event, which is not yet included as a major complication of the procedure. It is probably due to the presence of fluoroquinolone-resistant bacteria in faeces. It is, therefore, important to highlight this possibility and to stress the use of targeted antibiotic prophylaxis after rectal flora swabbing with selected antibiotics at sufficient concentrations to be effectiv

  15. A Rectourethral Fistula due to Transrectal High-Intensity Focused Ultrasound Treatment: Diagnosis and Management.

    Science.gov (United States)

    Fiaschetti, Valeria; Manenti, Guglielmo; Di Poce, Isabelle; Fornari, Maria; Ricci, Aurora; Finazzi Agrò, Enrico; Simonetti, Giovanni

    2012-01-01

    Colovesical fistula (CVF) is an abnormal connection between the enteric and the urinary systems. The rectourethral fistula (RUF) is a possible but extremely rare complication of treatment of prostate cancer with "transrectal High-Intensity Focused Ultrasound (HIFU) treatment." We present a case of CVF due to HIFU treatment of recurrent prostate cancer. The case was assessed with cystography completed with a pelvic CT scan-with MPR, MIP, and VR reconstruction-before emptying the bladder. Since the CT scan confirmed that the fistula involved solely the urethra and excluded even a minimal involvement of the bladder, it was possible to employ a conservative treatment by positioning a Foley catheter of monthly duration, in order to allow the urethra to rest. Still today, after 6 months, the patient is in a good clinical condition and has not shown yet signs of a recurrence of the fistula.

  16. Evaluation of clinical efficacy of transrectal sonography and computed tomography for prostatic diseases

    Energy Technology Data Exchange (ETDEWEB)

    Watanabe, Hiroki; Ohe, Hiroshi; Tanahashi, Toshikatsu and others

    1988-07-01

    Receiver operating characteristics (ROC) analysis was performed to evaluate the clinical efficacy of transrectal sonography (US) and computed tomography (CT) for prostatic diseases. One hundred US and CT images of prostatic diseases collected from 10 medical institutions, including 33 cases of prostatic cancer, 29 of benign prostatic hypertrophy, 7 of prostatitis, 2 of prostatic stone and 29 of normal finding, were read by 21 urologists. As the results, US was found to be more useful than CT for both the detection of prostatic diseases and the differentiation between prostatic cancer and benign prostatic hypertrophy. The sensitivity of US for the diagnosis of prostatic cancer was 64.2 % on average of all the urologists. However, the sensitivity was 80.0 % on average of 5 urologists who have read more than 3,000 US images and 59.5 % on average of 16 doctors who have read within 3,000 US images.

  17. 3D transrectal ultrasound (TRUS) prostate segmentation based on optimal feature learning framework

    Science.gov (United States)

    Yang, Xiaofeng; Rossi, Peter J.; Jani, Ashesh B.; Mao, Hui; Curran, Walter J.; Liu, Tian

    2016-03-01

    We propose a 3D prostate segmentation method for transrectal ultrasound (TRUS) images, which is based on patch-based feature learning framework. Patient-specific anatomical features are extracted from aligned training images and adopted as signatures for each voxel. The most robust and informative features are identified by the feature selection process to train the kernel support vector machine (KSVM). The well-trained SVM was used to localize the prostate of the new patient. Our segmentation technique was validated with a clinical study of 10 patients. The accuracy of our approach was assessed using the manual segmentations (gold standard). The mean volume Dice overlap coefficient was 89.7%. In this study, we have developed a new prostate segmentation approach based on the optimal feature learning framework, demonstrated its clinical feasibility, and validated its accuracy with manual segmentations.

  18. A Rectourethral Fistula due to Transrectal High-Intensity Focused Ultrasound Treatment: Diagnosis and Management

    Directory of Open Access Journals (Sweden)

    Valeria Fiaschetti

    2012-01-01

    Full Text Available Colovesical fistula (CVF is an abnormal connection between the enteric and the urinary systems. The rectourethral fistula (RUF is a possible but extremely rare complication of treatment of prostate cancer with “transrectal High-Intensity Focused Ultrasound (HIFU treatment.” We present a case of CVF due to HIFU treatment of recurrent prostate cancer. The case was assessed with cystography completed with a pelvic CT scan—with MPR, MIP, and VR reconstruction—before emptying the bladder. Since the CT scan confirmed that the fistula involved solely the urethra and excluded even a minimal involvement of the bladder, it was possible to employ a conservative treatment by positioning a Foley catheter of monthly duration, in order to allow the urethra to rest. Still today, after 6 months, the patient is in a good clinical condition and has not shown yet signs of a recurrence of the fistula.

  19. Efficacy and cost analysis of transrectal ultrasound-guided prostate biopsy under monitored anesthesia

    Institute of Scientific and Technical Information of China (English)

    Sung Gu Kang; Bum Sik Tae; Sam Hong Mine; Young Hwu Ko; Seok Ho Kang; Jeong Gu Lee; Je Jong Kim; Jun Cheon

    2011-01-01

    @@ Sedation may result in reduction in pain during transrectal ultrasound(TRUS)-guided prostate biopsies.We aimed to evaluate the efficacy and safety of a combination of propofol and remifentanil infusion during TRUS-guided prostate biopsy and the related increases in health care costs.From January to September 2010,100 men undergoing a transrectal prostate biopsy were randomized into two groups.In Group 1,[50]patients received a combined infusion of propofol and remifentanil; in Group 2,[50]patients received lidocaine jelly.After TRUS-guided biopsies were performed,pain and patient satisfaction were evaluated by a 10-point visual analog scale (VAS),and a cost-related patient satisfaction questionnaire was completed by all patients.Patients were also asked whether they would be willing to undergo repeat biopsy by the same method.Patients in Group 1 showed a significantly lower VAS score than those in Group 2 (mean VAS score: 0.9士1.1 versus 6.312.5; P<0.001).In addition,the patient satisfaction scale was significantly higher in Group 1(P=0.002).Although the overall cost was significantly higher in Group 1(P=0.006),patient satisfaction scales considering cost were also higher in this group (P=0.009).A combination of propofol and remifentanil is a safe and effective way to decrease patient pain and increase patient satisfaction during TRUS-guided prostate biopsy.Although the costs were higher in the group that received sedation,as expected,the patients exhibited heightened satisfaction and willingness to repeat biopsies by the same method.

  20. Optical biopsy of the prostate: can we TRUST (trans-rectal ultrasound-coupled spectral tomography)?

    Science.gov (United States)

    Piao, Daqing; Jiang, Zhen; Bartels, Kenneth E.; Holyoak, G. Reed; Ritchey, Jerry W.; Rock, Kendra; Ownby, Charlotte L.; Bunting, Charles F.; Slobodov, Gennady

    2011-03-01

    Needle-based core-biopsy to locate prostate cancer relies heavily upon trans-rectal ultrasound (TRUS) imaging guidance. Ultrasonographic findings of classic hypoechoic peripheral zone lesions have a low specificity of ~28%, a low positive predictive value of ~29%, and an overall accuracy of ~43%, in prostate cancer diagnosis. The prevalence of isoechoic or nearly invisible prostate cancers on ultrasonography ranges from 25 to 42%. As a result, TRUS is useful and convenient to direct the needle trajectory following a systematic biopsy sampling template rather than to target only the potentially malignant lesion for focal-biopsy. To address this deficiency in the first-line of prostate cancer imaging, a trans-rectal ultrasound-coupled spectral tomography (TRUST) approach is being developed to non-invasively resolve the likely optical signatures of prostate malignancy. The approach has evolved from using one NIR wavelength to two NIR bands, and recently to three bands of NIR spectrum information. The concept has been evaluated on one normal canine prostate and three dogs with implanted prostate tumor developed as a model. The initial results implementing TRUST on the canine prostate tumor model includes: (1) quantifying substantially increased total hemoglobin concentration over the time-course of imaging in a rapidly growing prostate tumor; (2) confirming hypoxia in a prostatic cystic lesion; and (3) imaging hypoxic changes of a necrotic prostate tumor. Despite these interesting results, intensive technologic development is necessary for translating the approach to benefiting clinical practice, wherein the ultimate utility is not possibly to eliminate needle-biopsy but to perform focal-biopsy that is only necessary to confirm the cancer, as well as to monitor and predict treatment responses.

  1. The effect of video-based education on patient anxiety in men undergoing transrectal prostate biopsy.

    Science.gov (United States)

    Tarhan, Huseyin; Cakmak, Ozgur; Unal, Elif; Akarken, Ilker; Un, Sitki; Ekin, Rahmi Gokhan; Konyalioglu, Ersin; Isoglu, Cemal Selcuk; Zorlu, Ferruh

    2014-11-01

    We assess the effect of video-based education on patient anxiety during transrectal prostate biopsy. A total of 246 patients who underwent transrectal prostate biopsy were prospectively enrolled in the study. Group 1 included 123 patients who received both written and video-based education, while Group 2 included 123 patients who received only written instructions regarding prostate biopsies. State-Trait Anxiety Inventory (STAI) was used to assess state and trait anxiety (STAI-S/T) After completing the STAI-S and STAI-T questionnaires, all patients in Group 1 received written information and video-based education and they again completed STAI-S before the biopsy. On the contrary, after completing the STAI-S and STAI-T questionnaires, the patients in Group 2 received only written information and then they completed the STAI-S before the biopsy. Moreover, a visual analog scale (VAS) was used to assess pain scores during digital rectal examination, probe insertion, periprostatic local anesthesic infiltration, and biopsy. No difference was noted between 2 groups regarding VAS scores. Comparing the 2 groups on baseline anxiety, we found that trait anxiety scores (STAI-T) were similar (p = 0.238). Pre-information STAI-S scores were similar in both groups (p = 0.889) and they both indicated high anxiety levels (score ≥42). While post-information STAI-S scores remained high in Group 2, post-information STAI-S scores significantly decreased in Group 1 (p = 0.01). Undergoing a prostate biopsy is stressful and may cause anxiety for patients. Video-based education about the procedure can diminish patient anxiety.

  2. Transrectal ultrasound (TRUS) guided prostate biopsy: Three different types of local anesthesia.

    Science.gov (United States)

    Anastasi, Giuseppina; Subba, Enrica; Pappalardo, Rosa; Macchione, Luciano; Ricotta, Gioacchino; Muscarà, Graziella; Lembo, Francesco; Magno, Carlo

    2016-12-30

    Transrectal Ultrasound (TRUS) guided prostate biopsy is regarded as the gold standard for prostate cancer diagnosis. The majority of patients perceive TRUS-guided prostate biopsy as a physically and psychologically traumatic experience. We aimed to compare in this paper the efficacy of three different anesthesia techniques to control the pain during the procedure. 150 patients who underwent transrectal ultrasound (TRUS) guided prostate biopsy were randomly divided into three groups. Group A included 50 patients who received one hour before the procedure a mixture of 2.5% lidocaine and 2.5% prilocaine, Group B: 50 patients who received intrarectal local anesthetic administration (lidocaine 5 ml 10%) and lidocaine local spray 15 % and Group C included 50 patients who received periprostatic block anesthesia (lidocaine 10 ml 10%). Visual analogue scale (VAS) of patients in different groups was evaluated at the end of the biopsy and 30 minutes after the procedure. The VAS of patients in Group A was 1.32 ± 0.65 (VAS I) and 2.47 ± 0.80 (VAS II). In group B the VAS of patients was 1.09 ± 0.47 (VAS I) and 1.65 ± 0.61 (VAS II). In group C the VAS of patients was 2.63 ± 0.78 (VAS I) and 1.70 ± 0.85 (VAS II). There was no statistically significant difference in term of VAS I between group A and B. A statistically significant difference was determined in terms of VAS II between group A and B. There was no statistically significant difference in term of VAS between group B and C. The most effective of the three methods for pain control we used was intrarectal local anesthetic administration and lidocaine local spray 15% that enables an ideal patient comfort.

  3. Effectiveness of stress management in patients undergoing transrectal ultrasound-guided biopsy of the prostate

    Directory of Open Access Journals (Sweden)

    Chiu LP

    2016-02-01

    Full Text Available Li-Pin Chiu,1,2 Heng-Hsin Tung,3 Kuan-Chia Lin,3 Yu-Wei Lai,1,4 Yi-Chun Chiu,1,4 Saint Shiou-Sheng Chen,1,4 Allen W Chiu1,4 1Division of Urology, Taipei City Hospital, 2University of Taipei, General Education Center, 3School of Nursing, Department of Care Management, National Taipei University of Nursing and Health Science, 4Department of Urology, National Yang-Ming University School of Medicine, Taipei, Taiwan, Republic of China Background: To assess the utilization of stress management in relieving anxiety and pain among patients who undergo transrectal ultrasound (TRUS-guided biopsy of the prostate.  Methods: Eighty-two patients admitted to a community hospital for a TRUS biopsy of the prostate participated in this case-controlled study. They were divided into an experimental group that was provided with stress management and a control group that received only routine nursing care. Stress management included music therapy and one-on-one simulation education. Before and after the TRUS biopsy, the patients’ state-anxiety inventory score, pain visual analogue scale (VAS, respiratory rate, heart rate, and blood pressure were obtained.  Results: There were no differences in baseline and disease characteristics between the two groups. The VAS in both groups increased after the TRUS biopsy, but the difference in pre- and postbiopsy VAS scores was significantly lower in the experimental group (P=0.03. Patients in both groups experienced mild anxiety before and after the biopsy, but those in the experimental group displayed a significantly greater decrease in postbiopsy state-anxiety inventory score compared to the control group (P=0.02.Conclusion: Stress management can alleviate anxiety and pain in patients who received a TRUS biopsy of the prostate under local anesthesia. Keywords: anxiety, pain, stress management, transrectal ultrasound-guided biopsy of the prostate

  4. Desarrollo de técnicas para determinar mutaciones del gen K- ras de pacientes con cáncer de pulmón

    Directory of Open Access Journals (Sweden)

    Moreno Pablo

    2004-12-01

    Full Text Available Se desarrolló un protocolo de procesamiento y extracción de ADN para cada uno de los tipos de muestras analizadas: Lavados broncoalveolares (BAL, Biopsias y Tejidos incluidos en parafina (TEPs colectadas de pacientes con cáncer de pulmón de célula no pequeña tipo adenocarcinoma o carcinoma escamocelular. La amplificación de los fragmentos del codón 12 de Kras se realizó utilizando la técnica de “PCR enriquecida”. Se obtuvo un porcentaje de amplificación del 84,6% para biopsias, 70% para BAL y 73,2% para TEPs para un total de 70 muestras, distribuidas en 11 biopsias, siete BAL y 52 TEPs. Se detectaron 18 (25.3% mutaciones en las 70 muestras analizadas: cinco biopsias, tres BAL y diez TEPs. De las 18 mutaciones detectadas, 15 fueron encontradas en hombres fumadores con edad promedio de 68 años. Las restantes tres
    mutaciones fueron encontradas en mujeres no fumadoras con edad promedio de 66 años. 77,7% (14 de las 18 muestras con mutaciones corresponden a tumores de tipo adenocarcinoma mientras solo el 37,5% (3 corresponden a tumores de tipo escamocelular. Todas las muestras con mutación corresponden a tumores de estados avanzados del cáncer. Los resultados hallados corresponden a un reporte preliminar del estado de la mutación K-ras codón 12 en
    tumores de cáncer de pulmón, sin embargo los datos no coinciden con los reportes de la literatura mundial, principalmente debido a variaciones poblacionales, sensibilidad del método de detección y cantidad y tipo de muestra analizada. Además, estos datos describen algunas de las
    características propias de la población portadora de la mutación.

  5. Characterization of prostate cancer, benign prostatic hyperplasia and normal prostates using transrectal 31phosphorus magnetic resonance spectroscopy: a preliminary report

    Energy Technology Data Exchange (ETDEWEB)

    Narayan, P.; Jajodia, P.; Kurhanewicz, J.; Thomas, A.; MacDonald, J.; Hubesch, B.; Hedgcock, M.; Anderson, C.M.; James, T.L.; Tanagho, E.A. (Univ. of California School of Medicine, San Francisco (USA))

    1991-07-01

    We assessed the ability of 31phosphorus (31P) transrectal magnetic resonance spectroscopy to characterize normal human prostates as well as prostates with benign and malignant neoplasms. With a transrectal probe that we devised for surface coil spectroscopy we studied 15 individuals with normal (5), benign hyperplastic (4) and malignant (6) prostates. Digital rectal examination, transrectal ultrasonography and magnetic resonance imaging were used to aid in accurate positioning of the transrectal probe against the region of interest within the prostate. The major findings of the in vivo studies were that normal prostates had phosphocreatine-to-adenosine triphosphate (ATP) ratios of 1.2 +/- 0.2, phosphomonoester-to-beta-ATP ratios of 1.1 +/- 0.1 and phosphomonoester-to-phosphocreatine ratios of 0.9 +/- 0.1. Malignant prostates had phosphocreatine-to-beta-ATP ratios that were lower (0.7 +/- 0.1) than those of normal prostates (p less than 0.02) or prostates with benign hyperplasia. Malignant prostates had phosphomonoester-to-beta-ATP ratios (1.8 +/- 0.2) that were higher than that of normal prostates (p less than 0.02). Using the phosphomonoester-to-phosphocreatine ratio, it was possible to differentiate metabolically malignant (2.7 +/- 0.3) from normal prostates (p less than 0.001), with no overlap of individual ratios. The mean phosphomonoester-to-phosphocreatine ratio (1.5 +/- 0.5) of prostates with benign hyperplasia was midway between the normal and malignant ratios, and there was overlap between individual phosphomonoester-to-phosphocreatine ratios of benign prostatic hyperplasia glands with that of normal and malignant glands. To verify the in vivo results, we performed high resolution magnetic resonance spectroscopy on perchloric acid extracts of benign prostatic hyperplasia tissue obtained at operation and on a human prostatic cancer cell line DU145.

  6. Doença de Lafora: diagnóstico pela biopsia de músculo esquelético (relato de caso Lafora's disease: diagnosis by muscle biopsy (case report

    Directory of Open Access Journals (Sweden)

    ALZIRA ALVES DE SIQUEIRA CARVALHO

    2000-12-01

    Full Text Available Uma paciente de 16 anos apresentava epilepsia mioclônica causada pela doença de Lafora. A biopsia muscular mostrou padrão vacuolar nas fibras musculares com as reações nicotinamida adenina tetrazolium redutase desidrogenase, hematoxilina-eosina e PAS. O aspecto morfológico permite o diagnóstico através da biopsia muscular. Este é um procedimento menos agressivo que a biopsia de fígado e de cérebro. A microscopia eletrônica deve ser reservada para casos nos quais as alterações musculares à microscopia óptica são muito discretas deixando dúvidas quanto ao diagnóstico.A 16-year-old female patient had myoclonic epilepsy caused by Lafora's disease. Muscle biopsy showed a prominent splitting pattern in muscle fibers with the nicotinamide adenine nucleotide dehydrogenase-tetrazolium reductase reaction, hematoxylin-eosin, and PAS stains. This morphologic appearance of the tissue permits diagnosis using the benign technique of muscle biopsy. The ultrastructural examination of muscle may be necessary to confirm the diagnosis of Lafora myoclonus epilepsy if light microscopical findings are equivocal.

  7. Biopsia hepática em cães: relação entre qualidade da amostra e grau de conclusão do diagnóstico

    Directory of Open Access Journals (Sweden)

    Tostes R.A.

    2002-01-01

    Full Text Available O presente estudo objetivou analisar a qualidade do diagnóstico de biopsias colhidas com agulhas tipo aspirativa e cortante, comparando-as ao exame histológico post-mortem do fígado de cães portadores de afecções hepáticas. Foram utilizados 60 cães, sem distinção de sexo, raça ou idade. As biopsias foram procedidas com agulhas tipo MenghiniÒ (de natureza aspirativa e agulhas tipo Tru-CutÒ (de natureza cortante. As biopsias foram colhidas utilizando-se a técnica percutânea transabdominal. O diagnóstico referente à agulha tipo Tru-CutÒ não diferiu do diagnóstico referente à agulha tipo MenghiniÒ. O referente à agulha tipo Tru-CutÒ foi o que apresentou maior índice de concordância, 88,3% de acertos. A agulha tipo Tru-CutÒ apresentou excelentes resultados independente da natureza das lesões, enquanto que a agulha tipo MenghiniÒ falhou nos casos de fibrose.

  8. Descripción de los casos de nefropatía lúpica diagnosticados por biopsia en el Hospital Universitario del Valle, Cali, 1995-2000.

    Directory of Open Access Journals (Sweden)

    Rodrigo Villalobos

    2009-11-01

    Full Text Available Se presenta un estudio descriptivo retrospectivo de 51 casos informados de nefropatía lúpica en el Departamento de Patología del Hospital Universitario del Valle, Cali, entre los años 1995 y 2000. Los casos fueron descritos según variables generales como sexo y grupo de edad al momento de la biopsia, diagnóstico histológico, grado de la nefropatía lúpica y puntajes del índice de actividad y cronicidad, según las definiciones aceptadas internacionalmente. Se hicieron comparaciones para determinar si existían diferencias en cuanto a las tendencias descritas entre las poblaciones pediátrica y adulta, encontrándose que los pacientes de 15 años y menos no muestran nefropatías de grados más graves, ni presentan índices de actividad y cronicidad peores que los adultos; sin embargo, estos datos no son estadísticamente significativos.

  9. [The transrectal ultrasonography of prostate in men with congenital hypogonadism treated by long term testosterone replacement therapy].

    Science.gov (United States)

    Heráček, Jiří; El Balouly, Karim; Sobotka, Vladimír; Šnajderová, Marta; Kalvachová, Božena; Urban, Michael

    2012-01-01

    The aim of the study was to evaluate prostate transrectal ultrasonography findings in men with congenital hypogonadism treated by long term testosterone replacement therapy. We have gradually included 31 men with congenital hypogonadism in period of 2001-2011. The average follow-up was 7.3 years (2 months - 10.8 years). We have used Sustanon® 250 i.m. every 3 weeks or Nebido® i.m. every 3 months for continual testosterone replacement therapy. We performed to all patients the transrectal ultrasonography of prostate and seminal vesicles by biplanar rectal probe every 6 months. During the transrectal ultrasonography we observed in 22 (71.0 %) patients changes in prostatic tissue. In case of 12 patients were diagnosed asymptomatic prostatic cysts, in 9 patients prostatolithiasis and in 5 patients changes in echogenity of prostatic tissue. In 2 patients was found simultaneous occurrence of prostatic cyst and prostolithiasis, in further 2 patients simultaneous occurrence of hyperechogenic prostatic lesion and prostatolithiasis. The above described findings were diagnosed in 5 patients in the treatment lasting from 3 to 5 years, for the other 17 men with hormone replacement therapy longer than 5 years. The study presents long term results of complex treatment in patients with disorders of sexual development, onset and progress of puberty. The long term treatment of these patients in interdisciplinary cooperation of endocrinologist and andrologist may significantly contribute to clarify an impact of testosterone replacement therapy on prostate development.

  10. Lateral pararectal versus transrectal stoma placement for prevention of parastomal herniation.

    Science.gov (United States)

    Hardt, Julia; Meerpohl, Joerg J; Metzendorf, Maria-Inti; Kienle, Peter; Post, Stefan; Herrle, Florian

    2013-11-22

    A parastomal hernia is defined as an incisional hernia related to a stoma and belongs to the most common stoma-related complications. Many factors concerning the operative technique which are considered to influence the incidence of parastomal herniation have been investigated. However, it remains unclear whether the enterostomy should be placed through or lateral to the rectus abdominis muscle in order to prevent parastomal herniation and other important stoma complications for people undergoing abdominal wall enterostomy. To assess if there is a difference regarding the incidence of parastomal herniation and other stomal complications, such as ileus and stenosis, in lateral pararectal versus transrectal stoma placement in people undergoing elective or emergency abdominal wall enterostomy. In October and November 2012 we searched for all types of published and unpublished randomized and non-randomized studies with no restriction on language, date or country (search dates in brackets). We searched the bibliographic databases The Cochrane Library (4 October 2012), MEDLINE (1 October 2012), EMBASE (10 October 2012), LILACS (29 November 2012), and Science Citation Index Expanded (4 October 2012). We also searched the reference lists of all relevant studies and the trial registers ClinicalTrials.gov (9 October 2012), World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) Search Portal (10 October 2012), as well as three additional trial registers not included in the ICTRP (27 November 2012). Randomized and non-randomized studies comparing lateral pararectal versus transrectal stoma placement with regard to parastomal herniation and other stoma-related complications. Two authors independently assessed study quality and extracted data. Data analyses were conducted according to the recommendations of The Cochrane Collaboration and the Cochrane Colorectal Cancer Group (CCCG). Quality of evidence was rated according to GRADE (Grading of

  11. Inflamación Granulomatosa Crónica: Métodos de detección de bacilos ácido alcohol resistentes en biopsias embebidas en parafina

    Directory of Open Access Journals (Sweden)

    Bustamante Rengifo Javier Andres

    2010-08-01

    Full Text Available

    La detección de bacilos ácido alcohol resistentes (BAAR en frotis resulta un aporte significativo al diagnóstico y tratamiento de individuos con inflamación granulomatosa crónica (IGC. Con el objetivo de evaluar la presencia de BAAR en diferentes tejidos de pacientes con IGC demostrada y comparar la frecuencia de los extendidos positivos para BAAR con el grado de formación de granulomas y necrosis, se diseño un estudio retrospectivo, en el que se seleccionaron 57 bloques embebidos en parafina que contenían biopsias de pleura, pulmón, pericardio, ganglio linfático y lóbulo cerebral, correspondientes a 30 pacientes (63.3% hombres, mayores de 18 años, con IGC demostrada y remitidos al departamento de patología del Hospital Universitario del Valle entre el 2002-2008, a cada muestra se le realizaron 3 cortes y se sometieron a tinciones de H/E, Zielh Neelsen y Auramina. La detección de BAAR en frotis fue similar para ambas tinciones especiales en

  12. Identifying the variables associated with pain during transrectal ultrasonography of the prostate

    Directory of Open Access Journals (Sweden)

    Hou CP

    2015-08-01

    Full Text Available Chen-Pang Hou,1,2 Yu-Hsiang Lin,1,2 Meng-Chiao Hsieh,3 Chien-Lun Chen,1,2 Phei-Lang Chang,1,2 Ying-Chen Huang,2 Ke-Hung Tsui1,21Department of Urology, Chang Gung Memorial Hospital at Linkou, 2School of Medicine, Chang Gung University, 3Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital at Chiayi, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan Objective: The purpose of this study was to prospectively investigate the degree of pain experienced by the patients receiving transrectal ultrasonography (TRUS of the prostate by applying a visual analog scale. We also identified the clinical parameters influencing pain during the TRUS examination.Materials and methods: Records were obtained from a prospective database for male patients who received TRUS of prostate in the outpatient department of Chang Gung Memorial Hospital, Taiwan, from January 2014 to June 2014. The patients underwent a detailed physical examination and medical history review. Immediately after the TRUS examination, the patients completed questionnaires based on a ten-point visual analog pain scale. The variables of interest were age, body mass index, prostate volume, prostate sagittal length, prostate-specific antigen, previous TRUS experience, external hemorrhoids, anal surgical history, prostate calcification, and image artifact caused by stool in the rectum. All variables were correlated to the visual analog scale by applying multivariate regression analysis.Results: By using linear regression analysis, we identified the independent factors that affected the pain score during the TRUS examination. The patients who received the examination for the first time or had longer prostate sagittal lengths, external hemorrhoids, anal surgical history, or stool stored in the rectum experienced more pain during the TRUS examination. Furthermore, the pain was reduced when we provided the patients with a detailed explanation before the procedure and

  13. The value and limitations of contrast-enhanced transrectal ultrasonography for the detection of prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Han-Xue, E-mail: zhaohx861@163.com [Department of Diagnostic Ultrasound, Beijing Tongren Hospital, Capital Medical University, Dong-Jiao-Min-Xiang, Dong Cheng District, Beijing 100730 (China); Xia, Chun-Xia, E-mail: star9901482@163.com [Department of Diagnostic Ultrasound, Beijing Tongren Hospital, Capital Medical University, Dong-Jiao-Min-Xiang, Dong Cheng District, Beijing 100730 (China); Yin, Hong-Xia, E-mail: hongxia_yin79@yahoo.com.cn [Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Dong-Jiao-Min-Xiang, Dong Cheng District, Beijing 100730 (China); Guo, Ning, E-mail: ningguo99@sina.com.cn [Department of Diagnostic Ultrasound, Beijing Tongren Hospital, Capital Medical University, Dong-Jiao-Min-Xiang, Dong Cheng District, Beijing 100730 (China); Zhu, Qiang, E-mail: qzhutrhos@gmail.com [Department of Diagnostic Ultrasound, Beijing Tongren Hospital, Capital Medical University, Dong-Jiao-Min-Xiang, Dong Cheng District, Beijing 100730 (China)

    2013-11-01

    Objectives: To evaluate the role of contrast-enhanced transrectal ultrasonography (CE-TRUS) for detecting prostate carcinoma. Methods: Sixty-five patients with elevated serum prostate-specific antigen (PSA) and/or abnormal digital rectal examination (DRE) were assessed using transrectal ultrasound (TRUS) and CE-TRUS. In all the patients, CE-TRUS was performed with intravenous injection of contrast agent (SonoVue, 2.4 ml) before biopsy. The cancer detection rates of the two techniques were compared. False-positive and false-negative findings related to CE-TRUS were analyzed in comparison to the pathological results of biopsy or radical prostatectomy. The targeted biopsy to abnormal CE-TRUS areas was also compared to systematic biopsy. Results: Prostate cancer was detected in 29 of the 65 patients. CE-TRUS showed rapid focal enhancement or asymmetric vessels of peripheral zones in 28 patients; 23 of them had prostate cancer. CE-TRUS had 79.3% sensitivity, compared to 65.5% of TRUS (P < 0.05). There were five false-positive and six false-negative findings from CE-TRUS. Benign prostate hyperplasia, and acute and chronic prostatitis were important causes related to the false-positive results of CE-TRUS. Prostate cancer originating from the transition zone or peripheral zone with lower PSA levels, small-size foci, and moderately or well-differentiated tumor was missed by CE-TRUS. The cancer detection rate of targeted biopsy (75%, 33/44 cores) was significantly higher than one of systematic biopsy (48.2%, 162/336) in those 28 cases (P < 0.05). In addition, no significant correlation was found between the cancer detection rate with CE-TRUS and serum PSA levels. Conclusion: CE-TRUS may improve the detection rate of prostate cancer through targeted biopsy of contrast-enhanced abnormalities. Our findings indicate that systematic biopsies should not be eliminated on the basis of false-positive and false-negative findings related to CE-TRUS.

  14. Experiencia con rituximab en miopatía inflamatoria idiopática refractaria

    Directory of Open Access Journals (Sweden)

    Elmer R. García-Salazar

    2013-10-01

    Full Text Available Se describe las características clínicas y de laboratorio de dos pacientes que recibieron rituximab por miopatía inflamatoria idiopática (MII. Ellas eran refractarias a tratamiento convencional con DARMES, por lo que recibieron rituximab 1 gramo cada 14 días, en dos infusiones en ciclo semestral. En las historias clínicas se obtuvo los datos clínicos de fuerza muscular proximal, lesiones cutáneas patognomónicas, elevación de CPK, TGO, DHL y VSG, resultados de electromiografía, biopsia muscular y de piel. Ninguno de los dos casos presentó reacción medicamentosa ni infecciones durante y posterior a las infusiones. Rituximab mostró efectividad en la respuesta clínica y enzimática en estas pacientes con dermatomiositis refractarias a corticoides y DARMES tradicionales.

  15. Características clínicas y anatomo-patológicas de las pacientes que ingresaron al Programa de Control de Tuberculosis con diagnóstico de tuberculosis de mama

    OpenAIRE

    Tafur, Karla; Cáceres, Jaime; ACCINELLI, Roberto

    2014-01-01

    Objetivo: Describir las características clínicas y anatomo-patológicas de pacientes que ingresaron con diagnóstico de TB de mama al Programa de control de Tuberculosis (PCT) de un hospital general. Material y métodos: Se incluyeron los casos registrados en el PCT como TB de mama en cuyo informe anatomo-patológico figuraba inflamación crónica granulomatosa. Se revisaron las historias clínicas y revaluaron las biopsias de mama. Resultados: Se incluyeron 69 mujeres con edad promedio 35,79 ± 7,94...

  16. Características clínicas y sociodemográficas de pacientes colombianos con Síndrome de Sjögren solo y asociado a otras enfermedades autoinmunes

    OpenAIRE

    Amador-Patarroyo, Manuel-José

    2013-01-01

    Introducción: Dado que una de las principales comorbilidades asociadas al síndrome de Sjögren es la presencia de otra enfermedad autoinmune, el objetivo de este estudio fue investigar la frecuencia de poliautoinmunidad en pacientes con síndrome de Sjögren y evaluar sus factores asociados. Métodos: Este fue un estudio de corte transversal en el que 410 pacientes con síndrome de Sjögren (por criterios del Consenso Americano-Europeo, incluyendo biopsia positiva) fueron sistemáticamente inclu...

  17. Combining artificial neural networks and transrectal ultrasound in the diagnosis of prostate cancer.

    Science.gov (United States)

    Porter, Christopher R; Crawford, E David

    2003-10-01

    Arguably the most important step in the prognosis of prostate cancer is early diagnosis. More than 1 million transrectal ultrasound (TRUS)-guided prostate needle biopsies are performed annually in the United States, resulting in the detection of 200,000 new cases per year. Unfortunately, the urologist's ability to diagnose prostate cancer has not kept pace with therapeutic advances; currently, many men are facing the need for prostate biopsy with the likelihood that the result will be inconclusive. This paper will focus on the tools available to assist the clinician in predicting the outcome of the prostate needle biopsy. We will examine the use of "machine learning" models (artificial intelligence), in the form of artificial neural networks (ANNs), to predict prostate biopsy outcomes using prebiopsy variables. Currently, six validated predictive models are available. Of these, five are machine learning models, and one is based on logistic regression. The role of ANNs in providing valuable predictive models to be used in conjunction with TRUS appears promising. In the few studies that have compared machine learning to traditional statistical methods, ANN and logistic regression appear to function equivalently when predicting biopsy outcome. With the introduction of more complex prebiopsy variables, ANNs are in a commanding position for use in predictive models. Easy and immediate physician access to these models will be imperative if their full potential is to be realized.

  18. Transrectal ultrasound-guided biopsy of the prostate: aspirin increases the incidence of minor bleeding complications

    Energy Technology Data Exchange (ETDEWEB)

    Halliwell, O.T. [Department of Radiology, Southampton General Hospital, Southampton (United Kingdom)], E-mail: hallo99@doctors.org.uk; Yadegafar, G. [Public Health Sciences and Medical Statistics Division, School of Medicine, Southampton General Hospital, Southampton University, Southampton (United Kingdom); Lane, C.; Dewbury, K.C. [Department of Radiology, Southampton General Hospital, Southampton (United Kingdom)

    2008-05-15

    Aim: To assess whether patients taking aspirin were more likely to experience bleeding complications after transrectal ultrasound (TRUS)-guided prostate biopsy. Materials and methods: Three hundred and eighty-seven patients taking aspirin who underwent prostate biopsy over a 3.5 year period and 731 patients not taking aspirin over a 2 year period returned a questionnaire assessing the incidence and severity of bleeding complications. Results: Patients taking aspirin had a significantly higher cumulative incidence of haematuria and rectal bleeding, but not of haemospermia. They also had a longer mean duration of bleeding, but no increase in bleeding severity. Severe bleeding was very uncommon in both groups and no patients required intervention for bleeding complications. Conclusion: Aspirin exacerbates minor bleeding complications in patients undergoing TRUS guided biopsy of the prostate, but in this large group of aspirin-taking patients no dangerous bleeding complications were encountered. It may be that the risks associated with aspirin cessation outweigh the risks of haemorrhagic complications.

  19. Complications and risk factors in transrectal ultrasound-guided prostate biopsies

    Directory of Open Access Journals (Sweden)

    Carlos Márcio Nóbrega de Jesus

    Full Text Available CONTEXT AND OBJECTIVE: Prostate biopsy is not a procedure without risk. There is concern about major complications and which antibiotics are best for routine use before these biopsies. The objective was to determine the rate of complications and the possible risk factors in prostate biopsies. DESIGN AND SETTING: Prospective study, Faculdade de Medicina de Botucatu. METHODS: Transrectal ultrasound (TRUS guided prostate biopsies were carried out in 174 patients presenting either abnormality in digital rectal examinations (DRE or levels higher than 4 ng/ml in prostate-specific antigen (PSA tests, or both. RESULTS: Hemorrhagic complications were the most common (75.3%, while infectious complications occurred in 19% of the cases. Hematuria was the most frequent type (56%. Urinary tract infection (UTI occurred in 16 patients (9.2%. Sepsis was observed in three patients (1.7%. The presence of an indwelling catheter was a risk factor for infectious complications (p < 0.05. Higher numbers of biopsies correlated with hematuria, rectal bleeding and infectious complications (p < 0.05. The other conditions investigated did not correlate with post-biopsy complications. CONCLUSIONS: Post-biopsy complications were mostly self-limiting. The rate of major complications was low, thus showing that TRUS guided prostate biopsy was safe and effective. Higher numbers of fragments taken in biopsies correlated with hematuria, rectal bleeding and infectious complications. An indwelling catheter represented a risk factor for infectious complications. The use of aspirin was not an absolute contraindication for TRUS.

  20. Diagnostic usefulness of the cytological study of the transport buffer in transrectal prostate core biopsies.

    Science.gov (United States)

    López, J I; Cáceres, F; Pérez, A; Caamaño, V; Larrinaga, G; Lecumberri, D; Arruza, A

    2014-11-01

    To evaluate the diagnostic usefulness of the cytological study of the transport buffer in the diagnosis of prostate adenocarcinoma in transrectal core biopsies. A total of 256 consecutively biopsied patients have been included in the analysis, 100 of them diagnosed of prostate adenocarcinoma. The procedure included the cytological analysis of the transport buffer and conventional histology. Cytological evaluation was performed in a blind way by the same pathologist. Overall sensitivity, specificity, and positive and negative predictive values to detect malignancy in the cytological slides were 54%, 98%, 94% and 76%, respectively. When restricted the analysis to cases with Gleason score higher than 8, sensitivity and negative predictive value increased to 85% and 97%, respectively. Similarly, when the analysis focused exclusively to cases with more than 5mm of cancer in the biopsy, sensitivity and positive predictive value increased to 66% and 96%, respectively. This study shows that whilst specificity was maintained in 98%, sensitivity, and positive and negative predictive values significantly improved in high grade and high volume adenocarcinomas. Our findings confirm that the cytological study of the transport buffer may complement the histology in the diagnosis of prostate adenocarcinoma. Copyright © 2014 AEU. Published by Elsevier Espana. All rights reserved.

  1. Granulomatous Prostatitis: Gray-scale Transrectal Ultrasonography and Color Doppler Ultrasonography Findings

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyoung Jung; Lim, Joo Won; Lee, Dong Ho; Ko, Young Tae; Kim, Eui Jong [Kyung Hee University Medical Center, Seoul (Korea, Republic of)

    2007-12-15

    We report here three cases of granulomatous prostatitis. All cases were confirmed by a transrectal ultrasonography (TRUS)-guided core biopsy of the prostate. Two cases received intravesical BCG therapy for a bladder tumor, and one case had no known predisposing condition. Gray-scale TRUS showed low echoic nodules in the outer gland in all cases. Color Doppler ultrasonography (CDUS) showed several dot-like blood flows within the low echoic nodules in two cases and several dot-like blood flows and short linear blood flows within the low echoic nodules in one case. Gray-scale TRUS findings of granulomatous prostatitis are similar to findings of prostate cancer. On CDUS, several dot-like blood flows or short linear blood flows were noted within the low echoic nodules in patients with granulomatous prostatitis. If low echoic nodules with dot-like or short linear blood flows are noted in patients with genitourinary tract tuberculosis or previous BCG therapy, granulomatous prostatitis should be included in the differential diagnosis. However, a prostatic biopsy is required for a final diagnosis

  2. Effectiveness of stress management in patients undergoing transrectal ultrasound-guided biopsy of the prostate.

    Science.gov (United States)

    Chiu, Li-Pin; Tung, Heng-Hsin; Lin, Kuan-Chia; Lai, Yu-Wei; Chiu, Yi-Chun; Chen, Saint Shiou-Sheng; Chiu, Allen W

    2016-01-01

    To assess the utilization of stress management in relieving anxiety and pain among patients who undergo transrectal ultrasound (TRUS)-guided biopsy of the prostate. Eighty-two patients admitted to a community hospital for a TRUS biopsy of the prostate participated in this case-controlled study. They were divided into an experimental group that was provided with stress management and a control group that received only routine nursing care. Stress management included music therapy and one-on-one simulation education. Before and after the TRUS biopsy, the patients' state-anxiety inventory score, pain visual analogue scale (VAS), respiratory rate, heart rate, and blood pressure were obtained. There were no differences in baseline and disease characteristics between the two groups. The VAS in both groups increased after the TRUS biopsy, but the difference in pre- and postbiopsy VAS scores was significantly lower in the experimental group (P=0.03). Patients in both groups experienced mild anxiety before and after the biopsy, but those in the experimental group displayed a significantly greater decrease in postbiopsy state-anxiety inventory score compared to the control group (P=0.02). Stress management can alleviate anxiety and pain in patients who received a TRUS biopsy of the prostate under local anesthesia.

  3. Focal lesion at the midline of the prostate on transrectal ultrasonography: take it or leave it?

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jun Woo; Hwang, Sung Il; Lee, Hak Jong; Hong, Sung Kyu; Byun, Seok Soo; Lee, Sang Chul; Choe, Ghee Young [Seoul National University Bundang Hospital, Seongnam (Korea, Republic of)

    2017-01-15

    The purpose of this study was to analyze the detection rate of prostate cancers from targeted biopsy specimens of midline focal lesions and to investigate the ultrasonographic findings to reduce unnecessary additional targeted biopsies. Ninety-eight men with midline focal lesions detected on transrectal ultrasonography were enrolled. Additional targeted biopsies for midline focal lesions were performed after 12-core random systematic biopsies. Correlations between the ultrasonographic characteristics of midline focal lesions and the pathologic results were analyzed. Twenty of 98 targeted biopsy cores (20.4%) were positive for malignancy. In a univariate analysis, midline focal lesions without bulging contours (P=0.023), with involved margins (P=0.001), without hypoechoic perilesional rims (P=0.005), and with longer diameters (P=0.005) were statistically significant for cancer detection. In a multivariate analysis, involved margin (P=0.027), having longer diameter (P=0.011) or absence of hypoechoic perilesional rim (P=0.025) made a statistically significant contribution to cancer detection. Biopsy of midline focal lesions was not always non-significant in the detection of prostate cancer. Additional targeted biopsies should be considered in cases of midline focal lesions with involved margins but without hypoechoic perilesional rims.

  4. Rare complication after a transrectal ultrasound guided prostate biopsy: a giant retroperitoneal hematoma.

    Science.gov (United States)

    Chiancone, Francesco; Mirone, Vincenzo; Fedelini, Maurizio; Meccariello, Clemente; Pucci, Luigi; Carrino, Maurizio; Fedelini, Paolo

    2016-05-24

    Common complications related to transrectal ultrasound (TRUS) guided prostatic needle biopsy are hematuria, hematospermia, and hematochezia. To the best of our knowledge, we report the second case of a very large hematoma extending from the pelvis into the retroperitoneal space in literature.A 66-year-old man with a serum prostate-specific antigen (PSA) of 5.4 ng/ml was admitted to our department for a TRUS-guided prostatic needle biopsy. Laboratory values on the day before biopsy, including coagulation studies, were all normal. The patients did not take any anticoagulant drugs. No immediate complications were encountered. Nevertheless, 7 hours after the biopsy, the patient reached our emergency department with severe diffuse abdominal pain, hypotension, tachycardia, and confusional state. He underwent an ultrasonography and then a computed tomography (CT) scan that showed "a blood collection in the pelvis that extending to the lower pole of left kidney associated with a focus of active contrast extravasation, indicating active ongoing prostate bleeding." Consequently, he underwent a diagnostic angiography that showed no more contrast extravasation, without the need of embolization. Management of hematoma has been conservative and hematoma was completely reabsorbed 4 months later.

  5. Possibility of transrectal photoacoustic imaging-guided biopsy for detection of prostate cancer

    Science.gov (United States)

    Ishihara, Miya; Shinchi, Masayuki; Horiguchi, Akio; Shinmoto, Hiroshi; Tsuda, Hitoshi; Irisawa, Kaku; Wada, Takatsugu; Asano, Tomohiko

    2017-03-01

    A transrectral ultrasonography (TRUS) guided prostate biopsy is mandatory for histological diagnosis in patients with an elevated serum prostate-specific antigen (PSA), but its diagnostic accuracy is not satisfactory; therefore, a considerable number of patients are forced to have an unnecessary repeated biopsy. Photoacoustic (PA) imaging has the ability to visualize the distribution of hemoglobin clearly. Thus, there is the potential to acquire different maps of small vessel networks between cancerous and normal tissue. We developed an original TRUS-type PA probe consisting of a microconvex array transducer with an optical illumination system providing coregistered PA and ultrasound images. The purpose of this study is to demonstrate the clinical possibility of a transrectral PA image. The prostate biopsy cores obtained by transrectal systemic biopsies under TRUS guidance were stained with HE staining and anti-CD34 antibodies as a marker of the endothelium of the blood vessel in order to find a pattern in the map of a small vessel network, which allows for imaging-based identification of prostate cancer. We analyzed the association of PA signal patterns, the cancer location by a magnetic resonance imaging (MRI) study, and the pathological diagnosis with CD34 stains as a prospective intervention study. In order to demonstrate the TRUS-merged-with-PA imaging guided targeted biopsy combined with a standard biopsy for capturing the clinically significant tumors, we developed a puncture needle guide attachment for the original TRUS-type PA probe.

  6. Quinolone Prophylaxis in Transrectal Ultrasound Guided Prostate Biopsy: An Eight-Year Single Center Experience

    Directory of Open Access Journals (Sweden)

    Bing-Juin Chiang

    2013-01-01

    Full Text Available We retrospectively evaluated the efficacy of prophylaxis with pipemidic acid and levofloxacin in transrectal ultrasound guided prostate biopsy (TRUSP-Bx. From January 2002 to December 2004, patients receiving oral pipemidic acid 500 mg twice daily for three days with or without a preoperative intravenous cefazolin 1 gm injection comprised group A. Between January 2005 and December 2009, patients receiving oral levofloxacin 500 mg one hour before biopsy comprised group B. We calculated the annual febrile urinary tract infection (fUTI rates. Patients’ characteristics, including age, prophylactic antibiotics, biopsy core numbers, pathologic results, PSA, and the spectrums and susceptibility of pathogens, were also evaluated. A total of 1313 (35.5% patients belonged to group A, while 2381 (64.5% patients belonged to group B. Seventy-three patients experienced postoperative infectious complications. There was a significant difference in the fUTI rate between groups A and B (3.7% versus 1.0%, P<0.001. The yearly fUTI rates varied from 0.6 to 3.9% between 2002 and 2009. Of the 73 patients with fUTI, those receiving levofloxacin prophylaxis were more likely to harbor fluoroquinolone-resistant pathogens (P<0.001. E. coli was the most common pathogen in both groups. Levofloxacin remains effective and appears superior to pipemidic acid based prophylaxis.

  7. Comparison of Two Local Anesthesia Injection Methods During a Transrectal Ultrasonography-guided Prostate Biopsy

    Energy Technology Data Exchange (ETDEWEB)

    Baek, Song Ee; Oh, Young Taik [Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul (Korea, Republic of); Kim, Jang Hwan; Rha, Koon Ho; Hong, Sung Joon; Yang, Seung Choul [Yonsei University College of Medicine, Seoul (Korea, Republic of)

    2010-09-15

    To compare the effectiveness of 2 injection methods of lidocaine during a transrectal ultrasound (TRUS)-guided prostate biopsy for pain control and complication rates. We retrospectively evaluated patients who underwent a TRUS-guided prostate biopsy from March 2005 to March 2006. One hundred patients were categorized into two groups based on injection method. For group 1, 10 mL of 1% lidocaine was injected bilaterally at the junction of the seminal vesicle and prostate and for group 2, into Denonvilliers' fascia. Pain scores using a visual analog scale (VAS) as well as immediate and delayed complication rates were evaluated. The mean VAS score showed no significant differences between the groups (group 1, 3.4{+-}1.78: group 2, 2.8{+-}1.3: p = 0.062). The difference in delayed complication rates and incidence of hematuria, hemospermia, and blood via the rectum was not significant between groups. However, two patients in group 1 complained of symptoms immediately after local anesthesia: one of tinnitus and the other of mild dizziness. There were no significant differences between pain control and complication rates between the 2 lidocaine injection methods. However, injection into Denonvilliers' fascia is thought to have less potential risk

  8. Fuentes de variabilidad en el diagnóstico de gastritis atrófica multifocal asociada con la infección por Helicobacter pylori

    Directory of Open Access Journals (Sweden)

    Luis Eduardo Bravo

    2008-03-01

    Full Text Available Introducción: El mapeo de las diferentes regiones del estómago y el número de fragmentos de mucosa gástrica disponibles para evaluación histopatológica son fuentes importantes de variación en el momento de clasificar y hacer la gradación de la gastritis crónica. Objetivos: Estimar la sensibilidad del número de fragmentos de mucosa gástrica necesarios para establecer los diagnósticos de gastritis atrófica con metaplasia intestinal (MI, displasia y estado de infección por Helicobacter pylori. Además evaluar la variabilidad intra-observador en la clasificación de estas lesiones precursoras del cáncer gástrico. Materiales y métodos: En una cohorte de 6 años de seguimiento se evaluaron 1,958 procedimientos de endoscopia realizados por dos gastroenterólogos. En cada procedimiento y de cada participante se obtuvieron 5 biopsias de mucosa gástrica que representaban antro, incisura angularis y cuerpo. Un único patólogo hizo la interpretación histológica de las 5 biopsias y proporcionó un diagnóstico definitivo global que se utilizó como patrón de referencia. Cada fragmento de mucosa gástrica examinado condujo a un diagnóstico individual para cada biopsia que se comparó con el patrón de referencia. La variabilidad intra-observador se evaluó en 127 personas que corresponden a una muestra aleatoria de 20% del total de endoscopias hechas a los 72 meses de seguimiento.Resultados: La sensibilidad del diagnóstico de MI y displasia gástrica aumentó de manera significativa con el número de fragmentos de mucosa gástrica evaluados El sitio anatómico de mayor sensibilidad para el diagnóstico de MI y displasia fue la incisura angularis. Para descubrir H. pylori se logró alta sensibilidad con el estudio de un solo fragmento de mucosa gástrica (95.9% y fue independiente del sitio de obtención de la biopsia. El acuerdo intra-observador para el diagnóstico de gastritis crónica fue 86.1% con valor kappa de 0.79 IC 95% (0

  9. Fuentes de variabilidad en el diagnóstico de gastritis atrófica multifocal asociada con la infección por Helicobacter pylori1

    Science.gov (United States)

    Bravo, Luis Eduardo; Bravo, Juan Carlos; Realpe, José Luis; Zarama, Guillermo; Piazuelo, MarÍa Blanca; Correa, Pelayo

    2014-01-01

    RESUMEN Introducción El mapeo de las diferentes regiones del estómago y el número de fragmentos de mucosa gástrica disponibles para evaluación histopatológica son fuentes importantes de variación en el momento de clasificar y hacer la gradación de la gastritis crónica. Objetivos Estimar la sensibilidad del número de fragmentos de mucosa gástrica necesarios para establecer los diagnósticos de gastritis atrófica con metaplasia intestinal (MI), displasia y estado de infección por Helicobacter pylori. Además evaluar la variabilidad intra-observador en la clasificación de estas lesiones precursoras del cáncer gástrico. Materiales y métodos En una cohorte de 6 años de seguimiento se evaluaron 1,958 procedimientos de endoscopia realizados por dos gastroenterólogos. En cada procedimiento y de cada participante se obtuvieron 5 biopsias de mucosa gástrica que representaban antro, incisura angularis y cuerpo. Un único patólogo hizo la interpretación histológica de las 5 biopsias y proporcionó un diagnóstico definitivo global que se utilizó como patrón de referencia. Cada fragmento de mucosa gástrica examinado condujo a un diagnóstico individual para cada biopsia que se comparó con el patrón de referencia. La variabilidad intra-observador se evaluó en 127 personas que corresponden a una muestra aleatoria de 20% del total de endoscopias hechas a los 72 meses de seguimiento. Resultados La sensibilidad del diagnóstico de MI y displasia gástrica aumentó de manera significativa con el número de fragmentos de mucosa gástrica evaluados El sitio anatómico de mayor sensibilidad para el diagnóstico de MI y displasia fue la incisura angularis. Para descubrir H. pylori se logró alta sensibilidad con el estudio de un solo fragmento de mucosa gástrica (95.9%) y fue independiente del sitio de obtención de la biopsia. El acuerdo intra-observador para el diagnóstico de gastritis crónica fue 86.1% con valor kappa de 0.79 IC 95% (0.76-0.85). Las

  10. No es posible predecir la afectación unilateral en pacientes con cáncer de próstata de bajo riesgo

    OpenAIRE

    Garau Perelló, Carmen

    2012-01-01

    OBJETIVO: Identificar factores predictivos de afectación unilateral en el cáncer de próstata (CaP) de bajo riesgo. MATERIAL Y METODOS: 95 pacientes con CaP de bajo riesgo. Evaluamos la presencia de CaP unilateral en la pieza de prostatectomía. Se realizó análisis uni y multivariante estudiando las variables: edad, PSA, volumen prostático, porcentaje de cilindros afectos y presencia de biopsias previas. RESULTADOS: el 36% presentaron CaP unilateral en la pieza. No se han encontrado diferencias...

  11. Análisis ultraestructural de la formación ósea en relación con el OsteoGen®

    OpenAIRE

    C. López Valenzuela; E. Javer Manzur; S. Arroyo Palacios; A. Oyarzun Droguett

    2002-01-01

    El OsteoGen®, ha sido profusamente utilizado como material osteoconductor en cirugía periodontal. Sin embargo las características estructurales de la interfase y del hueso neoformado han sido escasamente evaluadas en el ser humano. Con el objeto de estudiar la calidad de la reparación ósea alrededor de OsteoGen®, se injertó el material en defectos óseos de dos pacientes . Las biopsias fueron tomadas a los 6 y 12 meses y procesadas para microscopía optica ( MO ) y electrónica de transmisión ( ...

  12. Different optical spectral characteristics in a necrotic transmissible venereal tumor and a cystic lesion in the same canine prostate observed by triple-band trans-rectal optical tomography under trans-rectal ultrasound guidance

    Science.gov (United States)

    Jiang, Zhen; Holyoak, G. Reed; Ritchey, Jerry W.; Bartels, Kenneth E.; Rock, Kendra; Ownby, Charlotte L.; Slobodov, Gennady; Bunting, Charles F.; Piao, Daqing

    2011-03-01

    Different optical spectral characteristics were observed in a necrotic transmissible venereal tumor (TVT) and a cystic lesion in the same canine prostate by triple-wavelength trans-rectal optical tomography under trans-rectal ultrasound (TRUS) guidance. The NIR imager acquiring at 705nm, 785nm and 808nm was used to quantify both the total hemoglobin concentration (HbT) and oxygen saturation (StO2) in the prostate. The TVT tumor in the canine prostate as a model of prostate cancer was induced in a 7-year old, 27 kg dog. A 2 mL suspension of 2.5x106 cells/mL of homogenized TVT cells recovered from an in vivo subcutaneously propagated TVT tumor in an NOD/SCID mouse were injected in the cranial aspect of the right lobe of the canine prostate. The left lobe of the prostate had a cystic lesion present before TVT inoculation. After the TVT homogenate injection, the prostate was monitored weekly over a 9-week period, using trans-rectal NIR and TRUS in grey-scale and Doppler. A TVT mass within the right lobe developed a necrotic center during the later stages of this study, as the mass presented with substantially increased [HbT] in the periphery, with an area of reduced StO2 less than the area of the mass itself shown on ultrasonography. Conversely, the cystic lesion presented with slightly increased [HbT] in the periphery of the lesion shown on ultrasound with oxygen-reduction inside and in the periphery of the lesion. There was no detectable change of blood flow on Doppler US in the periphery of the cystic lesion. The slightly increased [HbT] in the periphery of the cystic lesion was correlated with intra-lesional hemorrhage upon histopathologic examination.

  13. THE PROGNOSTIC AND DIAGNOSTIC VALUE OF REPEATED TRANSRECTAL PROSTATE SATURATION BIOPSY

    Directory of Open Access Journals (Sweden)

    M. A. Kurdzhiev

    2014-08-01

    Full Text Available Objective: to determine the rate of prostate cancer (PC development after repeated transrectal saturation prostate biopsy (RTRSPB, to study the characteristics of diagnosed tumors, and to estimate their clinical significance from the data of radical retropubic prostatectomy (RRP.Materials and methods. The results of RTRSPB were analyzed in 226 patients with a later evaluation of a tumor from the results of RRP. All the patients underwent at least 2 prostate biopsies (mean 2.4. The average number of biopsy cores was 26.7 (range 24—30. The average value of total prostate-specific antigen before saturation biopsy was 7.5 (range 7.5 to 28.6 ng/ml. The mean age of patients was 62 years (range 53 to 70.  Results. PC was diagnosed in 14.6% of cases (33/226. An isolated lesion of the prostatic transition zone was in 12.1% of cases. If this zone had been excluded from the biopsy scheme, the detection rate of PC during saturation biopsy should be reduced by 13.8%. Better PC detectability during repeated saturation biopsy generally occurred due to the localized forms of the disease (93.3%. The agreement of Gleason tumor grading in the biopsy and prostatectomy specimens was noted in 66.7% of cases.Conclusion. Saturation biopsy allows prediction of a pathological stage of PC, Gleason grade of a tumor and its site localization with a greater probability. Most tumors detectable by saturation biopsy were clinically significant, which makes it possible to recommend RTRSPB to some cohort of high PC-risk patients 

  14. Automatic localization of the da Vinci surgical instrument tips in 3-D transrectal ultrasound.

    Science.gov (United States)

    Mohareri, Omid; Ramezani, Mahdi; Adebar, Troy K; Abolmaesumi, Purang; Salcudean, Septimiu E

    2013-09-01

    Robot-assisted laparoscopic radical prostatectomy (RALRP) using the da Vinci surgical system is the current state-of-the-art treatment option for clinically confined prostate cancer. Given the limited field of view of the surgical site in RALRP, several groups have proposed the integration of transrectal ultrasound (TRUS) imaging in the surgical workflow to assist with accurate resection of the prostate and the sparing of the neurovascular bundles (NVBs). We previously introduced a robotic TRUS manipulator and a method for automatically tracking da Vinci surgical instruments with the TRUS imaging plane, in order to facilitate the integration of intraoperative TRUS in RALRP. Rapid and automatic registration of the kinematic frames of the da Vinci surgical system and the robotic TRUS probe manipulator is a critical component of the instrument tracking system. In this paper, we propose a fully automatic registration technique based on automatic 3-D TRUS localization of robot instrument tips pressed against the air-tissue boundary anterior to the prostate. The detection approach uses a multiscale filtering technique to identify and localize surgical instrument tips in the TRUS volume, and could also be used to detect other surface fiducials in 3-D ultrasound. Experiments have been performed using a tissue phantom and two ex vivo tissue samples to show the feasibility of the proposed methods. Also, an initial in vivo evaluation of the system has been carried out on a live anaesthetized dog with a da Vinci Si surgical system and a target registration error (defined as the root mean square distance of corresponding points after registration) of 2.68 mm has been achieved. Results show this method's accuracy and consistency for automatic registration of TRUS images to the da Vinci surgical system.

  15. Comparative Effectiveness of Single versus Combination Antibiotic Prophylaxis for Infections after Transrectal Prostate Biopsy.

    Science.gov (United States)

    Marino, Kaylee; Parlee, Anne; Orlando, Ralph; Lerner, Lori; Strymish, Judith; Gupta, Kalpana

    2015-12-01

    An increase in fluoroquinolone resistance and transrectal ultrasound-guided prostate (TRUS) biopsy infections has prompted the need for alternative effective antibiotic prophylaxis. We aimed to compare ciprofloxacin and other single-agent therapies to combination therapy for efficacy and adverse effects. Men who underwent a TRUS biopsy within the VA Boston health care system with documented receipt of prophylactic antibiotics periprocedure were eligible for inclusion. Postprocedure infections within 30 days were ascertained by chart review from electronic records, including any inpatient, outpatient, or urgent-care visits. Among 455 evaluable men over a 3-year period, there were 25 infections (5.49%), with sepsis occurring in 2.4%, urinary tract infections (UTI) in 1.54%, and bacteremia in 0.44% of patients. Escherichia coli was the most common urine (89%) and blood (92%) pathogen, with fluoroquinolone resistance rates of 88% and 91%, respectively. Ciprofloxacin alone was associated with significantly more infections than ciprofloxacin plus an additional agent (P = 0.014). Intramuscular gentamicin alone was also significantly associated with a higher infection rate obtained with all other regimens (P = 0.004). Any single-agent regimen, including ciprofloxacin, ceftriaxone, or gentamicin, was associated with significantly higher infection rates than any combination regimen (odds ratio [OR], 4; 95% confidence interval [CI], 1.47, 10.85; P = 0.004). Diabetes, immunosuppressive condition or medication, hospitalization within the previous year, and UTI within the previous 6 months were not associated with infection risk. Clostridium difficile infections were similar. These findings suggest that ciprofloxacin, ceftriaxone, and gentamicin alone are inferior to a combination regimen. Institutions with high failure rates of prophylaxis for TRUS biopsies should consider combination regimens derived from their local data.

  16. Sepsis and 'superbugs': should we favour the transperineal over the transrectal approach for prostate biopsy?

    Science.gov (United States)

    Grummet, Jeremy P; Weerakoon, Mahesha; Huang, Sean; Lawrentschuk, Nathan; Frydenberg, Mark; Moon, Daniel A; O'Reilly, Mary; Murphy, Declan

    2014-09-01

    To determine the rate of hospital re-admission for sepsis after transperineal (TP) biopsy using both local data and worldwide literature, as there is growing interest in TP biopsy as an alternative to transrectal ultrasonography (TRUS)-guided biopsy for patients undergoing repeat prostate biopsy. Pooled prospective databases on TP biopsy from multiple centres in Melbourne were queried for rates of re-admission for infection. A literature review of PubMed and Embase was also conducted using the search terms: 'prostate biopsy, fever, infection, sepsis, septicaemia and complications'. In all, 245 TP biopsies were performed (111 at Alfred Health, 92 at Epworth Healthcare, 38 at Peter MacCallum Cancer Centre, and four at other institutions). The rate of hospital re-admission for infection was zero. The literature review showed that the rate of sepsis after TRUS biopsy appears to be rising with increasing rates of multi-resistant bacteria found in rectal flora, and is as high as 5%. However, the rate of sepsis from published series of TP biopsy approached zero. Both local and international data suggest a negligible rate of sepsis with TP biopsy. This compares to a concerning rise in the rate of sepsis after TRUS biopsy due to the increasing prevalence of multi-resistant bacteria in rectal flora. Although TRUS biopsy is convenient, cheap and quick to perform, we think that TP biopsy should now be offered as an option, not only to patients undergoing repeat prostate biopsy, but to all patients in whom a prostate biopsy is indicated. © 2013 The Authors. BJU International © 2013 BJU International.

  17. The results of transperineal versus transrectal prostate biopsy: a systematic review and meta-analysis

    Institute of Scientific and Technical Information of China (English)

    Peng-Fei Shen; Yu-Chun Zhu; Wu-Ran Wei; Yong-Zhong Li; Jie Yang; Yu-Tao Li; Ding-Ming Li; Jia Wang; Hao Zeng

    2012-01-01

    This systematic review was performed to compare the efficacy and complications of transperineal (TP) vs.transrectal (TR) prostate biopsy.A systematic research of PUBMED,EMBASE and the Cochrane Library was performed to identify all clinical controlled trials on prostate cancer (PCa) detection rate and complications achieved by TP and TR biopsies.Prostate biopsies included sextant,extensive and saturation biopsy procedures.All patients were assigned to a TR group and a TP group.Subgroup analysis was performed according to prostate-specific antigen (PSA) levels and digital rectal examination (DRE) findings.The Cochrane Collaboration's RevMan 5.1 software was used for the meta-analysis.A total of seven trials,including three randomized controlled trials (RCTs) and four case- control studies (CCS),met our inclusion criteria.There was no significant difference in the cancer detection rate between the sextant TR and TP groups (risk difference (RD),-0.02; 95% confidence interval (Cl),-0.08-0.03; P=0.34).Meta-analysis for RCTs combined with CCS showed that there was no difference in the cancer detection rate between the extensive TR and TP group (RD,-0.01; 95% CI,-0.05-0.04; P=0.81).There was no significant difference in PCa detection rate between the saturation TR and TP approaches (31.4% vs.25.7%,respectively; P=0.3).There were also no significant differences in cancer detection between the TR and TP groups in each subgroup.Although the data on complications were not pooled for the meta-analysis,no significant difference was found when comparing TR and TP studies.TR and TP biopsies were equivalent in terms of efficiency and related complications.TP prostate biopsy should be an available and alternative procedure for use by urologists.

  18. Safety of transrectal ultrasound-guided prostate biopsy in patients affected by Crohn’s disease

    Directory of Open Access Journals (Sweden)

    Lucio Dell'Atti

    2017-06-01

    Full Text Available Purpose: Crohn’s disease (CD is a chronic inflammatory condition of the gastrointestinal tract. It is usually considered a contraindication to transrectal ultrasound-guided prostate biopsy (TRUSBx. The aim of this study was to investigate the safety of TRUSBx in a small cohort of patients with CD. Methods: We queried our institutional database clinical data of patients with a diagnosis of CD undergoing TRUSBx, and a retrospective prospective study of 5 patients was planned. All patients enrolled were in the remission phase of CD and asymptomatic. They received the same antibiotic prophylaxis and a povidone-iodine aqueous solution enema before the procedure. A standardized reproducible technique was used with using a ultrasound machine equipped with a 5-9 MHz multifrequency convex probe “end-fire”. The patients were treated under local anaesthesia, and a 14-core biopsy scheme was performed in each patient as first intention. After the procedure each patient was given a verbal numeric pain scale to evaluate tolerability of TRUSBx. Results: TRUSBx was successfully completed in all patients. The number of biopsy cores was 14 (12-16. Of the 5 biopsy procedures performed 40% revealed prostatic carcinoma (PCa with a Gleason score 6 (3+3. No patients required catheterization or admission to the hospital for adverse events after the procedure. The most frequent adverse event was hematospermia (60%, while hematuria was present in 20% of patients and a minimal rectal bleeding in 20% of the patients. No patients reported severe or unbearable pain (score ≥ 8. Conclusions: This study suggests that CD may not be an absolute contraindication to TRUSBx for prostate cancer detection, but still requires a careful patients selection.

  19. Development and validation of a virtual reality transrectal ultrasound guided prostatic biopsy simulator

    Science.gov (United States)

    Chalasani, Venu; Cool, Derek W.; Sherebrin, Shi; Fenster, Aaron; Chin, Joseph; Izawa, Jonathan I

    2011-01-01

    Objective We present the design, reliability, face, content and construct validity testing of a virtual reality simulator for transrectal ultrasound (TRUS), which allows doctors-in-training to perform multiple different biopsy schemes. Methods This biopsy system design uses a regular “end-firing” TRUS probe. Movements of the probe are tracked with a micro-magnetic sensor to dynamically slice through a phantom patient’s 3D prostate volume to provide real-time continuous TRUS views. 3D TRUS scans during prostate biopsy clinics were recorded. Intrinsic reliability was assessed by comparing the left side of the prostate to the right side of the prostate for each biopsy. A content and face validity questionnaire was administered to 26 doctors to assess the simulator. Construct validity was assessed by comparing notes from experts and novices with regards to the time taken and the accuracy of each biopsy. Results Imaging data from 50 patients were integrated into the simulator. The completed VR TRUS simulator uses real patient images, and is able to provide simulation for 50 cases, with a haptic interface that uses a standard TRUS probe and biopsy needle. Intrinsic reliability was successfully demonstrated by comparing results from the left and right sides of the prostate. Face and content validity respondents noted the realism of the simulator, and its appropriateness as a teaching model. The simulator was able to distinguish between experts and novices during construct validity testing. Conclusions A virtual reality TRUS simulator has successfully been created. It has promising face, content and construct validity results. PMID:21470507

  20. Should Hypoechoic Lesions on Transrectal Ultrasound Be Sampled During Magnetic Resonance Imaging-targeted Prostate Biopsy?

    Science.gov (United States)

    Shakir, Nabeel A; Siddiqui, M Minhaj; George, Arvin K; Kongnyuy, Michael; Ho, Richard; Fascelli, Michele; Merino, Maria J; Turkbey, Baris; Choyke, Peter L; Wood, Bradford J; Pinto, Peter A

    2017-07-01

    To determine whether supplemental biopsy of hypoechoic ultrasound lesions (HUL) incidentally found during magnetic resonance imaging (MRI)-transrectal ultrasound (TRUS) fusion-targeted prostate biopsy results in improved prostate cancer (PCa) detection. Patients underwent MRI-TRUS-targeted biopsy as part of an ongoing prospective trial from August 2007 to February 2015. For men with HUL, the biopsy pathology of HUL and MRI lesions was classified according to the updated 2014 International Society of Urological Pathology (ISUP) grading system. The detection of PCa by MRI-targeted biopsy with and without HUL biopsy was compared. Of 1260 men in the trial, 106 underwent biopsy of 119 HULs. PCa was diagnosed in 52 out of 106 men (49%) by biopsy of either MRI lesions or HUL. Biopsy of HUL in addition to MRI lesions resulted in 4 additional diagnoses of high-grade (ISUP grades 3-5) PCa versus biopsy of MRI lesions alone (20 vs 16 men, P = .046). Three of these cases were upgraded from lower grade (ISUP grades 1-2) PCa on MRI-guided biopsy alone, and only 1 case (1% of cohort) was diagnosed that would have been missed by MRI-guided biopsy alone. Supplemental biopsy of HUL did not change the PCa risk category in 96% (102 out of 106) of men with HUL. Supplemental biopsy of HUL yields a small increase in the detection of higher grade PCa as compared with biopsy of MRI lesions alone. As upgrading is rare, routinely screening for HUL during MRI-targeted biopsy remains controversial. Copyright © 2016. Published by Elsevier Inc.

  1. Prospective Analysis on the Relation between Pain and Prostate Volume during Transrectal Prostate Biopsy

    Energy Technology Data Exchange (ETDEWEB)

    Yun, Tae Jin; Lee, Hak Jong; Kim, Seung Hyup; Lee, Sang Eun; Byun, Seok Soo; Hong, Sung Kyu; Cho, Jeong Yeon; Seong, Chang Kyu [Seoul National University Bundang Hospital, Institute of Radiation Medicine, Seoul (Korea, Republic of)

    2007-06-15

    We wanted to assess the relationship between pain and the prostate volume during transrectal ultrasound (TRUS) guided biopsy. Between July and September 2006, 71 patients scheduled for TRUS biopsy of the prostate were considered for inclusion to this study. These patients underwent periprostatic neurovascular bundle block with lidocaine prior to biopsy. Pain was assessed using a Visual Analogue Scale (VAS) during periprostatic neurovascular bundle block (VAS 1), during biopsy (VAS 2), and 20 minutes after biopsy (VAS 3). The mean pain scores were analyzed in the large prostate group (prostate volume > 40 cc) and the small prostate group (prostate volume {<=} 40 cc). P values < 0.05 were considered significant. The mean prostate volume was 42.2 cc (standard deviation: 8.6). The mean pain scores of VAS 1, 2 and 3 were 4.70 {+-} 1.61, 3.15 {+-}2.44 and 1.05 {+-} 1.51, respectively. In the large prostate group, the mean pains scores of VAS 1, 2 and 3 were 4.75 {+-} 1.76, 3.51 {+-} 2.76 and 1.29 {+-} 1.70, respectively, whereas in the small prostate group, the means pain scores were 4.66 {+-} 1.46, 2.77 {+-} 2.0, and 0.80 {+-} 1.26, respectively. Although there were no statistical differences of VAS 1, the larger prostate group revealed higher pain scores of VAS 2 and 3 compared with the small prostate group (p < 0.05). Patients with larger prostate volumes tend to feel more pain during and after TRUS guided prostate biopsy. Our findings suggest that additional analgesic strategies may be necessary when the patients with larger prostate undergo TRUS guided prostate biopsy.

  2. The effectivity of periprostatic nerve blockade for the pain control during transrectal ultrasound guided prostate biopsy

    Directory of Open Access Journals (Sweden)

    Alper Otunctemur

    2013-06-01

    Full Text Available Aim: Transrectal ultrasound (TRUS guided prostete biopsy is accepted as a standard procedure in the diagnosis of prostate cancer. Many different protocoles are applied to reduce the pain during the process. In this study we aimed to the comparison of two procedure with intrarectal lidocaine gel and periprostatice nerve blockade respective- ly in addition to perianal intrarectal lidocaine gel on the pain control in prostate biop- sy by TRUS. Methods: 473 patients who underwent prostate biopsy guided TRUS between 2008-2012 were included in the study. 10-point linear visual analog pain scale(VAS was used to evaluate the pain during biopsy. The patients were divided into two groups according to anesthesia procedure. In Group 1, there were 159 patients who had perianal-intrarectal lidocaine gel, in Group 2 there were 314 patients who had periprostatic nerve blockade in addition to intrarectal lidocain gel. The pain about probe manipulation was aseesed by VAS-1 and during the biopsy needle entries was evalu- ated by VAS-2. Results were compared with Mann-Whitney U and Pearson chi-square test. Results: Mean VAS-2 scores in Group 1 and Group 2 were 4.54 ± 1.02 and 2.06 ± 0.79 respectively. The pain score was determined significantly lower in the Group 2 (p = 0.001. In both groups there was no significant difference in VAS-1 scores, patient’s age, prostate volume, complication rate and PSA level. Conclusion: The combination of periprostatic nerve blockade and intrarectal lidocain gel provides a more meaningful pain relief compared to group of patients undergoing intrarectal lidocaine gel.

  3. Transrectal quantitative shear wave elastography in the detection and characterisation of prostate cancer.

    Science.gov (United States)

    Ahmad, Sarfraz; Cao, Rui; Varghese, Tomy; Bidaut, Luc; Nabi, Ghulam

    2013-09-01

    Shear wave imaging (SWI) is a new ultrasound technique whose application facilitates quantitative tissue elasticity assessment during transrectal ultrasound biopsies of the prostate gland. The aim of this study was to determine whether SWI quantitative data can differentiate between benign and malignant areas within prostate glands in men suspected of prostate cancer (PCa). We conducted a protocol-based, prospective, prebiopsy quantitative SWI of prostate glands in 50 unscreened men suspected of prostate cancer between July 2011 and May 2012. The ultrasound image of whole prostate gland was arbitrarily divided into 12 zones for sampling biopsies, as is carried out in routine clinical practice. Each region was imaged by grey scale and SWI imaging techniques. Each region was further biopsied irrespective of findings of grey scale or SWI on ultrasound. Additional biopsies were taken if SWI abnormal area was felt to be outside of these 12 zones. Quantitative assessment of SWI abnormal areas was obtained in kilopascals (kPa) from abnormal regions shown by SWI and compared with histopathology. Sensitivity, specificity, positive and negative predictive values, and likelihood ratios were calculated for SWI (histopathology was a reference standard). Fifty patients, with a mean age of 69 ± 6.2 years, were recruited into the study. Thirty-three (66%) patients were diagnosed with PCa, while an additional 4 (8%) had atypia in at least one of the 12 prostate biopsies. Thirteen (26%) patients had a benign biopsy. Data analysed per core for SWI findings showed that for patients with PSA 20 μg/L, the sensitivity and specificity were 0.93 and 0.93, respectively. In addition, PCa had significantly higher stiffness values compared to benign tissues (p stiffness differences in different Gleason grades. SWI provides quantitative assessment of the prostatic tissues and, in our preliminary observation, provides better diagnostic accuracy than grey-scale ultrasound imaging.

  4. Transrectal ultrasound-integrated spectral optical tomography of hypoxic progression of a regressing tumor in a canine prostate.

    Science.gov (United States)

    Jiang, Z; Piao, D; Bartels, K E; Holyoak, G R; Ritchey, J W; Ownby, C L; Rock, K; Slobodov, G

    2011-12-01

    The objective of this study was to evaluate if transrectal optical tomography implemented at three wavelength bands for spectral detection could monitor changes of the hemoglobin oxygen saturation (StO2) in addition to those of the total hemoglobin concentration ([HbT]) in lesions of a canine prostate, including an induced tumor modeling canine prostate cancer. Near-infrared (NIR) optical tomography was integrated with ultrasound (US) for transrectal imaging. Multi-spectral detection at 705_nm, 785_nm and 808_nm rendered measurements of [HbT] and StO2. Canine transmissible venereal tumor (TVT) cells were injected into the right lobe of a dog's prostate gland, which had a pre-existing cyst in the left lobe. Longitudinal assessments of the prostate were performed weekly over a 63-day duration by NIR imaging concurrent with grey-scale and Doppler US. Ultrasonography revealed a bi-lobular tumor-mass regressing from day-49 to day-63. At day-49 this tumor-mass developed a hypoxic core that became larger and more intense by day-56 and expanded further by day-63. The tumor-mass presented a strong hyper-[HbT] feature on day-56 that was inconsistent with US-visualized blood flow. Histology confirmed two necrotic TVT foci within this tumor-mass. The cyst appeared to have a large anoxic-like interior that was greater in size than its ultrasonographically delineated lesion, and a weak lesional elevation of [HbT]. On day-56, the cyst presented a strong hyper-[HbT] feature consistent with US-resolved blood flow. Histology revealed acute and chronic hemorrhage in the periphery of the cyst. The NIR imaging features of two other TVT nodules and a metastatic lymph node were evaluated retrospectively. Transrectal US-integrated spectral optical tomography seems to enable longitudinal monitoring of intra-lesional oxygenation dynamics in addition to the hemoglobin content of lesions in the canine prostate.

  5. Routine Ertapenem Prophylaxis for Transrectal Ultrasound Guided Prostate Biopsy does Not Select for Carbapenem Resistant Organisms: A Prospective Cohort Study.

    Science.gov (United States)

    Bloomfield, Maxim G; Page, Matthew J; McLachlan, Alice G; Studd, Rodney C; Blackmore, Timothy K

    2017-03-10

    Sepsis after transrectal ultrasound guided prostate biopsy is an increasing problem in this era of rising antibiotic resistance. Although ertapenem prophylaxis has proved effective at our institution to reduce this, it has raised local and regional antimicrobial stewardship concerns. We investigated the possible selective effect of single dose ertapenem prophylaxis on fecal colonization with carbapenem resistant Enterobacteriaceae. Patients underwent a rectal swab prior to receiving prebiopsy ertapenem prophylaxis. A second swab was obtained at followup 4 to 6 weeks later. Swabs were screened for carbapenem resistant Enterobacteriaceae using an enhanced CDC (Centers for Disease Control) method. Prebiopsy swabs were also screened for extended spectrum β-lactamase producing and ciprofloxacin resistant Enterobacteriaceae. Patients were monitored for post-biopsy sepsis. A total of 326 patients were enrolled in the study. At baseline 6.4% and 9.0% of patients had colonization with extended spectrum β-lactamase producing and ciprofloxacin resistant Enterobacteriaceae, respectively. Carbapenem resistant Enterobacteriaceae were not detected at baseline or followup in any patients. Colonization with nonfermentative organisms with intrinsic ertapenem resistance was detected in 29.4% of patients at baseline and followup (p = 1.0). Three cases (0.9%, 95% CI 0.2-2.8) of probable post-biopsy sepsis were identified during the study period. None was bacteremic or required intensive care unit admission. Single dose ertapenem prophylaxis did not appear to have a significant selective effect on fecal colonization with carbapenem resistant Enterobacteriaceae or other ertapenem resistant gram-negative organisms in this outpatient group. It is highly effective prophylaxis for transrectal ultrasound guided prostate biopsy. In the right setting ertapenem may represent a useful prophylactic option to prevent post-transrectal ultrasound guided prostate biopsy sepsis. Copyright © 2017

  6. Tolerance of local anesthetic for transrectal ultrasound-guided prostate biopsy: our experience and a literature review

    Energy Technology Data Exchange (ETDEWEB)

    Buckley, M.R.E.; Bryant, N.J.; Brown, J.A.; Tiwari, P.; Cooperberg, P.L.; Wong, A.D. [St Paul' s Hospital, Ultrasound Dept., Vancouver, British Columbia (Canada)]. E-mail: twong@providcencehealth.bc.ca

    2006-06-15

    To determine whether local anesthetic injection or gel reduced pain during transrectal ultrasound-guided prostate biopsies and whether there was significant difference between quadrant and apex-only anesthesia. Between September 2001 and May 2002, 240 male patients with elevated prostate-specific antigen and (or) abnormal digital rectal examination were randomized into 1 of 4 groups: 1) transrectal lidocaine gel, 2) quadrant lidocaine injections, 3) apex-only lidocaine injections, or 4) no local anesthetic. Patients scored their pain on a numerical rating scale where 0 indicated no pain and 10 indicated worst pain. We analyzed mean and standard deviations of scores, using a 1-way analysis of variance (ANOVA) and post hoc multiple comparisons with Tukey's honestly significant difference (HSD) studentized range test to determine whether there were significant differences across the groups. There was no significant difference between local anesthetic gel (mean 3.1, SD 1.9) and no anesthetic (mean 3.5, SD 1.9) or between quadrant (mean 1.7, SD 1.7) and apex-only (mean 2.0, SD 1.8) local anesthetic injections. There was significant difference between quadrant injections (mean 1.7, SD 1.7) and no local anesthetic (mean 3.5, SD 1.9) and between apex-only injections (mean 2.0, SD 1.8) and no local anesthetic (mean 3.5, SD 1.9). There was significant pain reduction with local anesthetic injections but not with gel, and since there was no significant difference in efficacy between quadrant and apex-only injections, we recommend apex-only local anesthetic injections for transrectal ultrasound-guided prostate biopsies because it simplifies the injection procedure. (author)

  7. Pain during Transrectal Ultrasound-Guided Prostate Biopsy and the Role of Periprostatic Nerve Block: What Radiologists Should Know

    Energy Technology Data Exchange (ETDEWEB)

    Nazir, Babar [Dept. of Oncologic Imaging, National Cancer Centre, Singapore (Singapore)

    2014-10-15

    Early prostate cancers are best detected with transrectal ultrasound (TRUS)-guided core biopsy of the prostate. Due to increased longevity and improved prostate cancer screening, more men are now subjected to TRUS-guided biopsy. To improve the detection rate of early prostate cancer, the current trend is to increase the number of cores obtained. The significant pain associated with the biopsy procedure is usually neglected in clinical practice. Although it is currently underutilized, the periprostatic nerve block is an effective technique to mitigate pain associated with prostate biopsy. This article reviews contemporary issues pertaining to pain during prostate biopsy and discusses the practical aspects of periprostatic nerve block.

  8. Transrectal ultrasonography-guided transperineal bilateral seminal vesicle puncture and continuous irrigation for the treatment of intractable hematospermia

    Institute of Scientific and Technical Information of China (English)

    ZHANG Xin-ru; GU Bao-jun; XU Yue-min; CHEN Rong; ZHANG Jiong; QIAO Yong

    2008-01-01

    @@ Hematospermia is a rare condition, but often causes frustration. The reason for this frustration is that the exact incidence of hematospermia remains unknown and its cause is difficult to determine.1 Many reports in the past decades have focused on the etiology of hematospermia.2 Hematospermia is treated initially by administration of antibiotics, coagulants, and sex steroid hormones. However, some cases may prove resistant to this therapy and the condition may continue. For some intractable and agnogenic cases, the therapeutic strategy mentioned above is not very effective. Recently, we treated 63 such nonresponsive patients by direct continuous antibiotic irrigation into the bilateral seminal vesicles through puncture under transrectal ultrasonography (TRUS) guidance.

  9. Correlation of transrectal ultrasonographic findings of the prostate with the occurrence of detrusor instability in patients with benign prostatic hyperplasia.

    Science.gov (United States)

    Tong, Y C; Lin, Y M; Yang, W H; Tzai, T S; Lin, J S

    1995-01-01

    Forty patients with benign prostatic hyperplasia were evaluated with urodynamics and transrectal ultrasonography. Seventeen patients were found to have detrusor instability while the remaining 23 did not. No significant differences were noted during ultrasonography in the estimated prostatic volume, the presumed circle area ratio and the incidence of finding prostatic calcification between these two groups. However, the incidence of detecting intravesical protrusion of the prostate is significantly higher in patients with instability than in patients with stable bladder (53 vs. 13%, p prostate and alter the stability status of the urinary bladder.

  10. Biopsia de médula ósea: Patrones morfológicos de las hemopatías y tumores sólidos en pediatría

    Directory of Open Access Journals (Sweden)

    Alma Torres Gómez de Cádiz Silva

    1996-12-01

    Full Text Available Se presentan los resultados del estudio de 165 biopsias de médula ósea realizadas a pacientes ingresados en el Hospital Pediátrico Docente "Juan Manuel Márquez". Las distintas afecciones que motivaron las biopsias fueron: enfermedades hematológicas no malignas, 56 casos; leucemia linfoblástica aguda, 9 casos; leucemia mieloide crónica juvenil, 2 casos; histiocitosis maligna, 1 caso; linfoma no Hodgkin, 25 casos; enfermedad de Hodgkin, 31 casos; neuroblastoma, 13 casos; sarcoma de partes blandas, 11 casos; neuroblastoma, 13 casos; evaluación del órgano posquimioterapia, 17 casos. Se describen las características morfológicas de la médula ósea en diferentes hemopatías y los patrones de infiltración de las leucemias y los tumores sólidos más frecuentes en el niño.The results of the study of 165 bone marrow biopsias performed to patients admitted in the "Juan Manuel Márquez" Pediatric Teaching Hospital, are presented. The different affections leading to biopsies were: non-malignant hematologic diseases, 56 cases; acute lymphoblastic leukemia, 9 cases; juvenile chronic myeloid leukemia, 2 cases; malignant histiocytosis, 1 case; non-Hodgking lymphoma, 25 cases; Hodgkin's disease, 31 cases, neuroblastoma, 13 cases; soft tissues sarcomas, 11 cases; and, postchemiotherapy organ evaluation, 17 cases. The morphological characteristics of the bone marrow in different hemopathies, as well as the infiltration patterns of leukemias and of the most common solid tumours in children, are described.

  11. Sensibilidad in vitro a amoxicilina y claritromicina de Helicobacter pylori obtenido de biopsias gástricas de pacientes en zona de bajo riesgo para cáncer gástrico

    OpenAIRE

    Mercedes Figueroa; Armando Cortés; Álvaro Pazos; Luis Eduardo Bravo

    2012-01-01

    Introducción. La infección por Helicobacter pylori prevalece en más de la mitad de la población mundial. Es prioritario evaluar la sensibilidad actual in vitro de H. pylori a los antimicrobianos usados en los protocolos de erradicación, fundamentalmente para determinar los patrones y resolver la infección. Objetivo. Determinar la prevalencia de la infección y la sensibilidad antibiótica de H. pylori en biopsias gástricas. Materiales y métodos. Se investigan la prevalencia de la infec...

  12. Osteosarcoma de huesos del pie con alto grado de malignidad

    Directory of Open Access Journals (Sweden)

    Alain Martínez Milián

    2015-05-01

    Full Text Available El osteosarcoma es la neoplasia primaria del hueso más frecuente, los hombres son los más afectados en una relación 1,2 - 1,5 por cada mujer y con una tasa de mortalidad cercana a 0,15/100.000 habitantes/año. Se reporta el caso de una paciente femenina de 57 años de edad, con dolor, aumento de volumen e impotencia funcional de aproximadamente seis meses de evolución, los exámenes diagnósticos utilizados fueron radiografía de pie, tomografía axial computarizada de miembro inferior y biopsia de hueso. Se tuvo la confirmación diagnóstica de osteosarcoma de alto grado de malignidad por anatomía patológica. El tratamiento realizado fue quirúrgico, practicándose la amputación del miembro inferior, pudiendo así mejorar la supervivencia y extendiéndole la vida a la paciente. El motivo de la presentación del caso está dado por la poca frecuencia de este tipo de tumor óseo en los huesos del pie en pacientes femeninas

  13. Utility of color Doppler transrectal ultrasound in the diagnosis of prostate cancer: a study of 101 cases; Utilidad de la ecografia transrectal con Doppler color en el diagnostico del cancer de prostata. Estudio de 101 casos

    Energy Technology Data Exchange (ETDEWEB)

    Morales, F. J.; Jornet, J.; Cervera, J.; Labrador, T. [Instituto Valenciano de Oncologia. Valencia (Spain)

    2001-07-01

    To determine the value of color Doppler ultrasound in the detection of prostate cancer. To relate asymmetries in vascularisation with the results of directed biopsy. Between May and November 2000, we studied 101 patients suspected of having prostate cancer. The selection criteria were a prostate-specific antigen level of over 3 ng/ml, suspicious digital rectal examination or both. The volume, capsule and internal architecture were assessed, focusing on nodules, suspicious hypoechoic areas and asymmetric color intensity. Sextant biopsies were carried out with an 18-gauge needle and samples were also taken of the areas of increased color intensity. (Author) 16 refs.

  14. DETECCIÓN DE BACILOS ÁCIDO ALCOHOL RESISTENTES EN BIOPSIAS EMBEBIDAS EN PARAFINA EN CASOS DE INFLAMACIÓN GRANULOMATOSA CRÓNICA.

    OpenAIRE

    JAVIER ANDRÉS BUSTAMANTE; MIRYAM ASTUDILLO; ALVARO JAIRO PAZOS; LUIS EDUARDO BRAVO

    2010-01-01

    La detección de bacilos ácido alcohol resistentes (BAAR) en frotis resulta un aporte significativo al diagnóstico y tratamiento de individuos con inflamación granulomatosa crónica (IGC). Con el objetivo de evaluar la presencia de BAAR en diferentes tejidos de pacientes con IGC demostrada y comparar la frecuencia de los extendidos positivos para BAAR con el grado de formación de granulomas y necrosis, se diseño un estudio retrospectivo, en el que se seleccionaron 57 bloques embebidos en parafi...

  15. Role of axillary lymph node ultra-sound and large core biopsy in the preoperative assessment of patients selected for sentinel node biopsy; Ruolo dell'ecografia e della microbiopsia istologica nella valutazione del cavo ascellare in pazienti candidate a biopsia del linfonodo sentinella

    Energy Technology Data Exchange (ETDEWEB)

    Nori, Jacopo; Boeri, Cecilia; Vanzi, Ermanno; Nori Bufalini, Filippo; Masi, Andrea [Azienda Ospedaliero-Universitaria Careggi, Firenze (Italy). Diagnostica senologica; Bazzocchi, Massimo; Londero, Viviana [Udine Univ., Udine (Italy). Istituto di radiologia universitaria; Mangialavori, Giuseppe [Ospedale di Merano, Bolzano (Italy). Servizio di radiologia; Distante, Vito; Simoncini, Roberta [Firenze Univ., Firenze (Italy). Clinica chirurgica I

    2005-04-01

    important sonographic alteration was the gradual reduction in hilar echogenicity (seen in 100% metastatic nodes); conversely, hilar denting of irregularities, as well as dimensional criteria, proved to be poorly specific. Conclusions: The sonographic assessment of axillary and internal mammary chain nodes, possibly in addition to core biopsy, improve the preoperative evaluation of breast cancer patients scheduled for conservative surgery of the breast (quadrantectomy) and the axilla (sentinel node biopsy). US findings suspicious for metastatic involvement of axillary lymph nodes should be considered as an exclusion criterion for sentinel node biopsy. A more widespread use of axillary node biopsy and an accurate sonographic evaluation of the excised lymph node increase the specificity of the procedure, allowing a better correlation between sonographic findings and definitive histology. [Italian] Scopo: Valutare l'accuratezza diagnostica preoperatoria dell'esame ecografico del cavo ascellare con studio dei linfonodi, associato eventualmente a microbiopsia ecoguidata-ove esista indicazione-in pazienti con carcinoma mammario candidate a quadrantectomia associata a biopsia del linfonodo sentinella. Materiale e metodi: Nel periodo compreso tra Luglio 2001 e Dicembre 2002 presso la nostra Diagnostica Senologica abbiamo studiato con ecografia e, ove indicato, microbiopsia istologica, 117 pazienti affette da neoplasia mammaria; le lesioni avevano diametri compresi tra 4.0 e 26 mm (diametro medio 11 mm). Rispetto al totale, 15 pazienti sono state escluse: nove di queste non soddisfacevano i requisiti richiesti dalla preliminare valutazione ecografica del cavo ascellare (non erano dicumentabili linfonodi oppure erano visibili solamente due linfoghiadole) mentre le altre 6 pazienti (con citologia prechirurgica dubbia o sospetta) sono risultate, all'istologia intraoperatoria, portatrici di patologia mammaria benigna. In 11 pazienti (10.7%), in relazione al dubbio

  16. Postprostatectomy ultrasound-guided transrectal implantation of gold markers for external beam radiotherapy. Technique and complications rate

    Energy Technology Data Exchange (ETDEWEB)

    Langenhuijsen, J.F.; Kiemeney, L.A.L.M.; Witjes, J.A. [Radboud Univ. Nijmegen Medical Center, Nijmegen (Netherlands). Dept. of Urology; Donker, R. [Medical Center Alkmaar (Netherlands). Dept. of Radiation Oncology; McColl, G.M.; Lin, E.N.J.T. van [Radboud Univ. Nijmegen Medical Center, Nijmegen (Netherlands). Dept. of Radiation Oncology

    2013-06-15

    Background and purpose: Postprostatectomy radiotherapy (RT) improves survival in adjuvant and salvage settings. The implantation technique and complications rate of gold markers in the prostate bed for high-precision RT were analyzed. Patients and methods: Patients undergoing postprostatectomy RT for prostate-specific antigen (PSA) relapse or high-risk disease were enrolled in the study. Under transrectal ultrasound guidance, three fine gold markers were implanted in the prostate bed and the technical difficulties of insertion were documented. Patients received our self-designed questionnaires concerning complications and pain. The influence of anticoagulants and coumarins on bleeding was analyzed, as was the effect of potential risk factors on pain. Results: In 77 consecutive patients, failure of marker implantation or marker migration was seen in six cases. Rectal bleeding was reported by 10 patients and 1 had voiding complaints. No macroscopic hematuria persisting for more than 3 days was observed. Other complications included rectal discomfort (n = 2), nausea (n = 1), abdominal discomfort (n = 1), and pain requiring analgesics (n = 4). No major complications were reported. On a 0-10 visual analogue scale (VAS), the mean pain score was 3.7. No clinically significant risk factors for complications were identified. Conclusion: Transrectal implantation of gold markers in the prostate bed is feasible and safe. Alternatives like cone beam computed tomography (CBCT) should be considered, but the advantages of gold marker implantation for high-precision postprostatectomy RT would seem to outweigh the minor risks involved. (orig.)

  17. The Accuracy of Prostate Cancer Localization Diagnosed on Transrectal Ultrasound-Guided Biopsy Compared to 3-Dimensional Transperineal Approach

    Directory of Open Access Journals (Sweden)

    Kevin Krughoff

    2013-01-01

    Full Text Available Background. Prostate cancer is often understaged following 12-core transrectal ultrasound- (TRUS- guided biopsies. Our goal is to understand where cancers are typically missed by this method. Methods. Transperineal 3-dimensional mapping biopsy (3DMB provides a more accurate depiction of disease status than transrectal ultrasound- (TRUS- guided biopsy. We compared 3DMB findings in men with prior TRUS-guided biopsies to determine grade and location of missed cancer. Results were evaluated for 161 men with low-risk organ confined prostate cancer. Results. The number of cancer-positive biopsy zones per patient with TRUS was 1.38 ± 1.21 compared to 3.33 ± 4.06 with 3DMB, with most newly discovered cancers originating from the middle lobe and apex. Approximately half of all newly discovered cancerous zones resulted from anterior 3DMB sampling. Gleason upgrade was recognized in 56 patients using 3DMB. When both biopsy methods found positive cores in a given zone, Gleason upgrades occurred most frequently in the middle left and right zones. TRUS cancer-positive zones not confirmed by 3DMB were most often the basal zones. Conclusion. Most cancer upgrades and cancers missed from TRUS biopsy originated in the middle left zone of the prostate, specifically in anterior regions. Anterior sampling may lead to more accurate diagnosis and appropriate followup.

  18. Systematic Analysis of Transrectal Prostate Biopsies Using an Ink Method and Specific Histopathologic Protocol: A Prospective Study

    Directory of Open Access Journals (Sweden)

    David Parada

    2011-01-01

    Full Text Available Background. Transrectal prostate biopsy is the standard protocol for the screening for prostate cancer. It helps to locate prostatic adenocarcinoma and plan treatment. However, the increasing number of prostate biopsies leads to considerably greater costs for the pathology laboratories. In this study, we compare the traditional method with an ink method in combination with a systematic histopathologic protocol. Methods. Two hundred consecutive transrectal prostate biopsy specimens were received from the radiology department. They were separated into two groups: one hundred were processed as six different specimens in the usual manner. The other one hundred were submitted in six containers, the apex, base, and middle section of which were stained different colours. The samples subject to the ink method were embedded in paraffin and placed in two cassettes which were sectioned using a specific protocol. Results. The comparative study of the nonink and ink methods for histopathologic diagnosis showed no statistical differences as far as diagnostic categories were concerned (value<.005. The number of PIN diagnoses increased when the ink method was used, but no statistical differences were found. The ink method led to a cost reduction of 48.86%. Conclusions. Our ink method combined with a specific histopathologic protocol provided the same diagnostic quality, tumor location information as the traditional method, and lower pathology expenses.

  19. Analgesic Efficacy of Intrarectal Instillation of Lidocaine Gel prior to Transrectal Ultrasound Guided Prostate Biopsy: A Prospective Randomized Trial

    Energy Technology Data Exchange (ETDEWEB)

    Yun, Tae Jin; Kim, Seung Hyup; Cho, Jeong Yeon [Seoul National University Hospital, Seoul (Korea, Republic of); Lee, Hak Jong; Lee, Sang Eun; Byun, Seok Soo [Seoul National University Bundang Hospital, Seongnam (Korea, Republic of); Seong, Chang Kyu [Seoul National University Borame Hospital, Seoul (Korea, Republic of)

    2006-06-15

    To assess the analgesic efficacy of intrarectal lidocaine gel instillation prior to periprostatic nerve block during transrectal, ultrasound-guided prostate biopsies. Between March 2004 and October 2004, 203 consecutive patients for prostate biopsies were randomized into two groups. In 90 patients of group A, 10ml of 2% lidocaine gel was instilled intrarectally 10 minutes prior to periprostatic neurovascular bundle block, while 113 patients of group B received only periprostatic neurovascular bundle block without lidocaine gel instillation. Pain was assessed with the visual analogue pain scale, during periprostatic neurovascular bundle block (VAS 1), during the biopsy procedures (VAS 2) and 20 minutes after the procedure (VAS 3). The difference in VAS scores between patients in the two groups was evaluated with the unpaired t-test, with p < 0.05 considered significant. Patients in group A experienced statistically less pain during transrectal ultrasound guided prostate biopsy (VAS 2, 2.994 versus 3.903, p < 0.01). However, no significant difference in VAS values could be demonstrated during periprostatic neurovascular bundle block (VAS 1, 4.761 versus 5.133, p > 0.05) or at after 20 minutes after the procedure (VAS 3, 0.9778 versus 1.257, p > 0.05). Intrarectal instillation of lidocaine gel leads to significant additional analgesic efficacy during the biopsy procedure. It is a simple, safe and rapid technique that should be considered in all patients undergoing TRUS guided prostate biopsy

  20. Contrast-enhanced transrectal ultrasonography for the detection of diffuse prostate cancer.

    Science.gov (United States)

    Gao, Y; Liao, X H; Lu, L; Wang, L; Ma, Y; Qin, H Z; Yan, X; Guo, P

    2016-03-01

    To evaluate the diagnostic accuracy of contrast-enhanced transrectal ultrasonography (CE-TRUS) versus baseline TRUS (combination of grey-scale and colour Doppler imaging) for diffuse prostate cancer. Forty-six patients without an obvious focal mass on baseline TRUS (grey-scale and colour Doppler), underwent additional CE-TRUS and TRUS-guided biopsy due to elevated levels of prostate-specific antigen (PSA ≥4 ng/ml) and/or abnormal digital rectal examination (DRE). In all patients, CE-TRUS was performed with intravenous injection of a contrast agent (sulphur hexafluoride microbubble; SonoVue, 2.4 ml) before biopsy. TRUS-guided biopsy targeted suspicious areas detected on CE-TRUS imaging or sampled the outer gland of the normal prostate. The final diagnosis was based on results of the TRUS-guided biopsy. The diagnostic accuracy of baseline TRUS and CE-TRUS for diffuse prostatic lesions was evaluated using receiver operating characteristic (ROC) curve analysis. Diffuse prostate cancer was present in 32 (69.5%) patients and absent in 14 (30.5%) patients. Nineteen patients had diffuse prostate cancer that was not detected by baseline TRUS, whereas 15 cases were identified using CE-TRUS. Conversely, five patients had benign prostatic hypertrophy (BPH) that was diagnosed as cancer by CE-TRUS, and two of these patients were diagnosed with BPH by baseline TRUS. The combined sensitivity, specificity, and accuracy were 87.5%, 64.2%, and 80.4%, respectively, for CE-TRUS, and 40.6%, 78.5%, and 52.1%, respectively, for baseline TRUS. The area under the ROC curve (AUC) values for the diagnostic accuracy of baseline CE-TRUS versus TRUS for diffuse prostate cancer differed significantly at 0.904 and 0.667, respectively (Z=4.098, pprostate cancer than baseline TRUS. CE-TRUS may improve cancer detection over baseline TRUS imaging for the diagnosis of diffuse prostate cancer in patients with an elevated PSA level. CE-TRUS detects diffuse prostate cancer without an obvious focal mass

  1. Patient information leaflets for Transrectal Ultrasound guided prostate biopsy: Results of North Thames deanery survey

    Directory of Open Access Journals (Sweden)

    Phipps Claire

    2010-01-01

    Full Text Available Abstract Background We evaluated the quality of patient information leaflets for Trans-Rectal Ultrasound guided prostate biopsies (TRUS-Bx in North Thames region. TRUS-Bx information leaflets were requested from 24 hospitals in the region. All hospitals were contacted by telephone, and non-responders were followed-up by postal survey. Leaflets received were evaluated for a clear description of the procedure, directions to TRUS-Bx location, a clear description of the procedure, contact for queries/concerns, information about preparation prior to procedure, information about regular medication, information on how to obtain results, instructions for follow-up arrangements, analgesia used and risk of morbidity/mortality. Additionally, the leaflets were evaluated for diagrams to clarify the procedure and the anatomy, and sources of additional information, such as reference to published articles or prostate cancer patient support groups/internet websites. Findings In summary, a total of 17 leaflets (77% were received. Of these, the majority (94% had a clear description of the procedure, contact for queries/concerns (82%, information about preparation prior to TRUS-Bx (71%. Directions to TRUS-Bx location (29%, and analgesia used (35%, was very poorly described, and information on obtaining results and follow-up arrangements were described in only 12 (71% leaflets. Complications such as risks of infection, haematuria, haematospermia and rectal bleeding, were generally explained (71%-76% of leaflets, urinary retention was mentioned in only 5 (29% leaflets and mortality in only 1 case. Descriptive diagrams of the procedure and prostate anatomy were very rarely used, and sources of additional information were limited to 1 published article and reference to 1 prostate cancer support group. Conclusions This study demonstrates that there is large variation in the information supplied in TRUS-Bx patient information leaflets in the North Thames region, with

  2. Temporal-based needle segmentation algorithm for transrectal ultrasound prostate biopsy procedures.

    Science.gov (United States)

    Cool, Derek W; Gardi, Lori; Romagnoli, Cesare; Saikaly, Manale; Izawa, Jonathan I; Fenster, Aaron

    2010-04-01

    Automatic identification of the biopsy-core tissue location during a prostate biopsy procedure would provide verification that targets were adequately sampled and would allow for appropriate intraprocedure biopsy target modification. Localization of the biopsy core requires accurate segmentation of the biopsy needle and needle tip from transrectal ultrasound (TRUS) biopsy images. A temporal-based TRUS needle segmentation algorithm was developed specifically for the prostate biopsy procedure to automatically identify the TRUS image containing the biopsy needle from a collection of 2D TRUS images and to segment the biopsy-core location from the 2D TRUS image. The temporal-based segmentation algorithm performs a temporal analysis on a series of biopsy TRUS images collected throughout needle insertion and withdrawal. Following the identification of points of needle insertion and retraction, the needle axis is segmented using a Hough transform-based algorithm, which is followed by a temporospectral TRUS analysis to identify the biopsy-needle tip. Validation of the temporal-based algorithm is performed on 108 TRUS biopsy sequences collected from the procedures of ten patients. The success of the temporal search to identify the proper images was manually assessed, while the accuracies of the needle-axis and needle-tip segmentations were quantitatively compared to implementations of two other needle segmentation algorithms within the literature. The needle segmentation algorithm demonstrated a >99% accuracy in identifying the TRUS image at the moment of needle insertion from the collection of real-time TRUS images throughout the insertion and withdrawal of the biopsy needle. The segmented biopsy-needle axes were accurate to within 2.3 +/- 2.0 degrees and 0.48 +/- 0.42 mm of the gold standard. Identification of the needle tip to within half of the biopsy-core length (<10 mm) was 95% successful with a mean error of 2.4 +/- 4.0 mm. Needle-tip detection using the temporal

  3. [Improvement of transrectal ultrasound. Artificial neural network analysis (ANNA) in detection and staging of prostatic carcinoma].

    Science.gov (United States)

    Loch, T; Leuschner, I; Genberg, C; Weichert-Jacobsen, K; Küppers, F; Retz, M; Lehmann, J; Yfantis, E; Evans, M; Tsarev, V; Stöckle, M

    2000-07-01

    As a result of the enhanced clinical application of prostate specific antigen (PSA), an increasing number of men are becoming candidates for prostate cancer work-up. A high PSA value over 20 ng/ml is a good indicator of the presence of prostate cancer, but within the range of 4-10 ng/ml, it is rather unreliable. Even more alarming is the fact that prostate cancer has been found in 12-37% of patients with a "normal" PSA value of under 4 ng/ml (Hybritech). While PSA is capable of indicating a statistical risk of prostate cancer in a defined patient population, it is not able to localize cancer within the prostate gland or guide a biopsy needle to a suspicious area. This necessitates an additional effective diagnostic technique that is able to localize or rule out a malignant growth within the prostate. The methods available for the detection of these prostate cancers are digital rectal examination (DRE) and Transrectal ultrasound (TRUS). DRE is not suitable for early detection, as about 70% of the palpable malignancies have already spread beyond the prostate. The classic problem of visual interpretation of TRUS images is that hypoechoic areas suspicious for cancer may be either normal or cancerous histologically. Moreover, about 25% of all cancers have been found to be isoechoic and therefore not distinguishable from normal-appearing areas. None of the current biopsy or imaging techniques are able to cope with this dilemma. Artificial neural networks (ANN) are complex nonlinear computational models, designed much like the neuronal organization of a brain. These networks are able to model complicated biologic relationships without making assumptions based on conventional statistical distributions. Applications in Medicine and Urology have been promising. One example of such an application will be discussed in detail: A new method of Artificial Neural Network Analysis (ANNA) was employed in an attempt to obtain existing subvisual information, other than the gray scale

  4. Fully automated prostate magnetic resonance imaging and transrectal ultrasound fusion via a probabilistic registration metric

    Science.gov (United States)

    Sparks, Rachel; Bloch, B. Nicholas; Feleppa, Ernest; Barratt, Dean; Madabhushi, Anant

    2013-03-01

    In this work, we present a novel, automated, registration method to fuse magnetic resonance imaging (MRI) and transrectal ultrasound (TRUS) images of the prostate. Our methodology consists of: (1) delineating the prostate on MRI, (2) building a probabilistic model of prostate location on TRUS, and (3) aligning the MRI prostate segmentation to the TRUS probabilistic model. TRUS-guided needle biopsy is the current gold standard for prostate cancer (CaP) diagnosis. Up to 40% of CaP lesions appear isoechoic on TRUS, hence TRUS-guided biopsy cannot reliably target CaP lesions and is associated with a high false negative rate. MRI is better able to distinguish CaP from benign prostatic tissue, but requires special equipment and training. MRI-TRUS fusion, whereby MRI is acquired pre-operatively and aligned to TRUS during the biopsy procedure, allows for information from both modalities to be used to help guide the biopsy. The use of MRI and TRUS in combination to guide biopsy at least doubles the yield of positive biopsies. Previous work on MRI-TRUS fusion has involved aligning manually determined fiducials or prostate surfaces to achieve image registration. The accuracy of these methods is dependent on the reader's ability to determine fiducials or prostate surfaces with minimal error, which is a difficult and time-consuming task. Our novel, fully automated MRI-TRUS fusion method represents a significant advance over the current state-of-the-art because it does not require manual intervention after TRUS acquisition. All necessary preprocessing steps (i.e. delineation of the prostate on MRI) can be performed offline prior to the biopsy procedure. We evaluated our method on seven patient studies, with B-mode TRUS and a 1.5 T surface coil MRI. Our method has a root mean square error (RMSE) for expertly selected fiducials (consisting of the urethra, calcifications, and the centroids of CaP nodules) of 3.39 +/- 0.85 mm.

  5. Tratamiento con electrocauterización de las lesiones premalignas del cérvix

    Directory of Open Access Journals (Sweden)

    Israel Meza G

    2014-11-01

    Full Text Available Se presentaron los resultados del tratamiento con electrocauterización de las neoplasias intraepiteliales del cérvix en 430 pacientes atendidas en el Hospital Universitario del Valle, en el Hospital San Juan de Dios y en el Centro Hospital Cañaveralejo en Cali, Colombia, entre 1982 y 1992. Inicialmente se seleccionaron 455 mujeres que consultaron con citologías anormales (inclusive Papanicolau II con cambios coilocíticos y atipias inflamatorias. Para el análisis final sólo se incluyeron 430 pacientes. A todas se les practicó colposcopia y biopsia dirigida y se confirmaba el diagnóstico de neoplasia intraepitelial del cérvix. Se hizo seguimiento con citología y colposcopia. Se obtuvo una respuesta global de 90.1% al primer tratamiento, respuesta que aumenta a 96.8% cuando se incluyeron las pacientes que respondieron a un segundo tratamiento. Se discuten las ventajas y desventajas del método con respeto a otros métodos existentes.

  6. Treatment of anastomotic leakage after rectal resection with transrectal vacuum-assisted drainage (VAC). A method for rapid control of pelvic sepsis and healing

    DEFF Research Database (Denmark)

    Nagell, Carl Frederik Otto; Holte, Kathrine

    2006-01-01

    OBJECTIVE: Anastomotic leakage after rectal resection is associated with high morbidity and mortality. Patients without peritonitis can be treated conservatively by transrectal rinsing and drainage. However, healing is often very slow, and formation of abundant scar tissue resulting in a poor fun...

  7. 经直肠彩色多普勒超声对增生前列腺内腺低回声前列腺痛与低回声增生结节的鉴别%A study of the hypoechoic hypertrophic lesions and hypoechoic cancer lesions in hypertrophic prostate inner glands with transrectal color doppler ultrasonography

    Institute of Scientific and Technical Information of China (English)

    Hui Wang; Rui Hou; Guang Yang; Wenin Xue; Shen Lv

    2008-01-01

    Objective: To observe the sonographic and hemodynamic features of hypoechoic hypertrophic lesions and hy-poechoic cancer lesions in the hypertrophic prostate inner glands, in order to raise the accuracy of early diagnosis rate for prostate cancer. Methods: 31 cases of hypoechoic hypertrophic lesions and 18 cases of hypoechoic cancer lesions in the hypertrophic prostata inner glands were observed by transrectal ultrasonography and comparatively analyze the shape, edge and the systolic peak velocity (Vs), resistance index (RI) and pulsatility index (PI) of the lesions. Results: In contrast with hypertrophic group, the cancer group presented irregular shape and unclear edge, and obviously higher Vs, RI and PI. Con-clusion: The sonographic appearance and Vs. RI. PI have important value in distinguishing hypoechoic hypertrophic lesions and hypoechoic cancer lesions in the hypertrophic prostate inner glands.

  8. Identificación de factores biológicos asociados con la afectación del ganglio centinela y/o los ganglios no centinela en el cáncer de mama

    OpenAIRE

    Beridze Vaktangova, Nana

    2014-01-01

    La técnica de la biopsia selectiva del ganglio centinela en el cáncer de mama no está exenta de falsos negativos, con un efecto adverso sobre el tratamiento óptimo de las pacientes. Además, su desarrollo nos plantea nuevos interrogantes, tales como la posibilidad de obviar la práctica de la técnica en aquellos casos de carcinomas de mama en estadio muy precoz o muy baja probabilidad de afectación ganglionar; o como identificar a ese importante porcentaje de mujeres (32-68 %) que presentan afe...

  9. COMPLEX TRANSRECTAL US WITH COLOR FLOW MAPPING, DOPPLER SONOGRAPHY AND SONOELASTOGRAFIEY IN PROSTATE CANCER EVALUATION

    Directory of Open Access Journals (Sweden)

    А. I. Mukhomor

    2014-07-01

    Full Text Available Oncology statistics shows steady increase of prostate cancer, since early diagnosis and adequate treatment are crucial. Among prostate imaging modalities sonoelastography (SEG has a special value for identifying suspicious dense foci in prostate, however more studies are still required to establishing accuracy and specificity with different SEG techniques for updating the prostate cancer diagnostics protocol.The aim of study was to evaluate sonoelastography capabilities for ultrasound guided prostate biopsy, comparing with gray scale and Doppler modalities.512 consecutively selected patients were examined (mean age of 56 years, mean prostate volume was 54 cm3, the average PSA about 14.3 ng/ml. All patients underwent prostate cancer diagnostic algorithm, including direct rectal exam, PSA level, transrectal ultrasound (TRUS with Doppler and SEG identification of suspicious foci, mostly in peripheral zones, followed by 10-point biopsy guided by ultrasound. According to aim we assigned patients to 4 groups: group 1 (n = 327 underwent gray scale and Doppler US guided prostate biopsy; in patients of group 2 (n = 106 – additionally SEG was applied (3 patients of this group was also performed MRI and MRS of the prostate; in group 3 there were patients with high level of PSA and negative TRUS guided biopsy; group 4 – of 41 patiens with prostatectomy and biochemical recidive of prostate.Among 430 cases included to this study in 318 patients (74 % prostate adenocarcinoma was revealed, in 270 (63 % patients – benign hyperplasia (BH. In group 1 cancer was diagnosed in 236 (72.1 ± 2.4 % patients, in group 2 – in 84 (79.2 ± 3.8 %. 19 false negative and 6 false positive results were registered in SEG enchanced US guided prostate biopsy. Routine TRUS indicate lesions with mean sizes about 0.8 ± 0,21 sm in compare with 0,5 ± 0,08 sm which were diagnose by SEG. Locuses which were marked as benign byTRUS with SEG hade never conatained neoplastic cells

  10. The diagnostic values of serum prostate specific antigen and transrectal contrast-enhanced ultrasonography of prostate cancer%血清 PSA 指标与经直肠超声造影对前列腺癌的诊断

    Institute of Scientific and Technical Information of China (English)

    朱林; 黄君; 詹洁群; 贾天利; 刘灿

    2015-01-01

    目的:探讨血清前列腺特异性抗原(PSA)指标,游离前列腺特异性抗原(f-PSA)、总前列腺特异性抗原(T-PSA),前列腺特异性抗原密度(PSAD)与经直肠前列腺超声造影对前列腺癌(Prostate Cancer,PCa)的诊断价值。方法:获取59例血清 PSA 升高的患者的 fPSA 及 T-PSA、前列腺体积的三个径(L、W、H),所有病例均经直肠超声造影检查,并在超声引导下进行前列腺穿刺。结果:前列腺癌组患者的发病年龄要比良性前列腺增生(Benign prostate hyperplasia,BPH)组大,PSAD 比 BPH 组高。前列腺癌组的 f/T-PSA 比良性前列腺增生组低。前列腺癌组患者的显影时间、达峰时间、加速时间较良性前列腺增生组患者短,绝对增强强度较良性前列腺增生组高。前列腺癌组患者的强度减半时间比良性前列腺增生组患者短。结论:前列腺癌组的前列腺造影结果表现为“快进快出”。血清 f/T-PSA、PSAD 及经直肠超声造影技术对前列腺良恶性病变的鉴别诊断具有一定的临床价值。%Aim:To study the value of serum PSA indicator (f/T-PSA,PSAD)and CETRUS (con-trast-enhanced transrectal ultrasound)in diagnosis of prostate cancer.Methods:Fifty-nine patients were elevated with serum PSA had fPSA (free prostate specific antigen)and T-PSA (total prostate specific an-tigen),three size (Long,Wide,Height),the 59 patients carry through CETRUS (contrast-enhanced transrectal ultrasound)and biopsy.Results:Prostate cancer patients’age of onset are older than benign prostate hyperplasia group,PSAD in prostate cancer group are higher than that of benign prostate hyper-plasia group,f/T-PSA in prostate cancer group are lower than that of benign prostate hyperplasia group. AT (arrival time),TTP (time to peak),ACT (acceleration time)in prostate cancer group are shorter than those of benign prostate hyperplasia group,absolute enhance intense (△PI =PI

  11. A multi-classifier system for the characterization of normal, infectious, and cancerous prostate tissues employing transrectal ultrasound images.

    Science.gov (United States)

    Glotsos, Dimitris; Kalatzis, Ioannis; Theocharakis, Pantelis; Georgiadis, Pantelis; Daskalakis, Antonis; Ninos, Kostas; Zoumboulis, Pavlos; Filippidou, Anna; Cavouras, Dionisis

    2010-01-01

    A computer-aided diagnostic system has been developed for the discrimination of normal, infectious and cancer prostate tissues based on texture analysis of transrectal ultrasound images. The proposed system has been designed using a panel of three classifiers, which have been evaluated individually or as a mutli-classifier scheme, using the external cross-validation procedure. Clinical data consisted of 165 transrectal ultrasound images, characterized by an experienced physician as normal (55/165), cancerous (55/165), and infectious (55/165) prostate cases. From each image, the physician delineated the most representative regions of interest, from which, 23 textural features were extracted. Classification was seen as a two level hierarchical decision tree. Normal from infectious and infectious from cancer cases were discriminated at the 1st and 2nd level of the decision tree, respectively. The best classification results for the 1st level were 89.5%, whereas for the 2nd level 90.1%. The utilization of multi-classifier system improved the discrimination of prostate pathologies as compared to individual classifiers; for infectious prostate cases improvement was from 87.3% to 88.7% and for cancer prostate cases improvement was from 84.1% to 91.4%. In terms of overall system performance (the decision tree's node propagating error taken into account), best classification accuracies were 89.5%, 79.6% and 82.7% for the recognition of normal, infectious and cancer cases, respectively. The proposed system might be used as a second opinion tool for assisting diagnosis of different prostate pathologies.

  12. Anemia y fiebre en el postrasplante renal: su relación con el parvovirus humano B19

    Directory of Open Access Journals (Sweden)

    Yanet Parodis López

    2017-03-01

    Presentamos el caso clínico de un varón de 65 años con trasplante renal de donante cadáver en septiembre de 2014. A los 38 días del trasplante comienza con anemia progresiva y resistente a los agentes estimulantes de la eritropoyesis. A los 64 días se produce hipertermia, con deterioro progresivo de su estado general. La serología vírica resultó negativa, al igual que la PCR inicial en sangre del parvovirus humano B19. A los 4 meses y 19 días se realiza una biopsia de médula ósea en la que se observan eritroblastos gigantes con inclusiones víricas nucleares compatibles con parvovirus, por lo que se realiza una PCR en dicho tejido que confirma el diagnóstico. Una segunda PCR en sangre resultó positiva. Tras el tratamiento con inmunoglobulinas intravenosas (IGIV y la suspensión temporal del micofenolato de mofetilo, se produce una remisión completa de la enfermedad, aunque persistía positiva la PCR para el parvovirus B19 en sangre, lo que hace necesario vigilar probables recidivas.

  13. Asociación sincrónica de carcinoma de paratiroides con tumor pardo mandibular y carcinoma papilar de tiroides

    OpenAIRE

    Jaime Alonso Reséndiz-Colosia; Sergio Arturo Rodríguez-Cuevas; Sinuhé Barroso-Bravo; José Francisco Gallegos-Hernández; Martín Hernández-San Juan; Fernando Gómez-Acosta

    2008-01-01

    Introducción: Los nódulos tiroideos en pacientes con hiperparatiroidismo primario son frecuentes, pero la asociación sincrónica de carcinoma de paratiroides y carcinoma papilar de tiroides es un evento poco común. Caso clínico: Paciente de 42 años de edad con tumor en región mandibular derecha y nódulo en la cara anterior de cuello que dependía del lóbulo derecho de tiroides. La biopsia por aspiración de la lesión en cavidad oral indicó lesión de células gigantes. Se identificó hipercalcemia ...

  14. Hiperoxaluria primaria con pancitopenia: a propósito de un caso

    Directory of Open Access Journals (Sweden)

    Jessica Bravo Zuñiga

    2005-06-01

    Full Text Available Se presenta el caso de un varón, de 15 años de edad, con diagnóstico de litiasis renal desde la infancia que evolucionó a Insuficiencia Renal Crónica, requiriendo hemodiálisis. Seis meses antes del reporte se agregan dolores articulares, con signos flogósicos en rodilla derecha, compromiso progresivo del estado general, pérdida de peso y anemia. Al examen físico se encuentra a un paciente emaciado, pálido, con múltiples adenopatías cervicales, y presencia de hepato-esplenomegalia. Se realizan exámenes evidenciándose: pancitopenia, con mayor compromiso de la serie roja (hemoglobina 7,3mg/dL, leucocitos 2 600/µL, y plaquetas 123 000/µL.. Los valores de transaminasas y bilirrubinas fueron normales así como los dosajes de Fierro, Transferrina, Ácido Fólico y Vitamina B12. La ecografía abdominal revela riñones calcificados y atróficos y los Rx de abdómen demuestran nefrocalcinosis y litiasis renal. La biopsia de medula ósea evidenció un extenso depósito de cristales de oxalato de calcio, dispuestos en forma radiada, con casi completa obliteración de la medula ósea con un número variable de células multinucleadas y fibrosis moderada. El aspirado de medula ósea no mostró cristales de oxalato de calcio. Este reporte hace una revisión sobre hiperoxaluria primaria, y resalta la importancia de reconocer la enfermedad como causa de falla renal en un paciente con historia clínica de litiasis renal y nefrocalcinosis. (Rev Med Hered 2004;16:148-156

  15. A comparison of transrectal hyperthermia, transurethral thermotherapy, urolume wallstent, and prostatic spiral for benign prostatic hyperplasia patients at poor operative risk.

    Science.gov (United States)

    Montorsi, F; Guazzoni, G; Bergamaschi, F; Consonni, P; Galli, L; Rigatti, P

    1994-01-01

    Transrectal hyperthermia, transurethral thermotherapy, prostatic stent, and prostatic spiral were used to treat 120 poor operative risk patients with symptomatic benign prostatic hyperplasia. The preoperative subjective and objective conditions of the four groups (each of 30 patients) were comparable. None of the patients had an indwelling catheter, but according to flow nomograms, all were obstructed. The greatest increase in peak flow rate was observed after stent placement, while the greatest decrease of residual urine volume was seen after the insertion of the stent and transrectal hyperthermia. According to maximum flow nomograms, only the placement of the stent resolved bladder outlet obstruction. The greatest improvement in subjective symptoms was the result of stent insertion, but the heating procedures also caused a significant reduction of symptom scores. The spiral produced satisfactory results only in the short term.

  16. A Prospective Comparison of Selective Multiparametric Magnetic Resonance Imaging Fusion-Targeted and Systematic Transrectal Ultrasound-Guided Biopsies for Detecting Prostate Cancer in Men Undergoing Repeated Biopsies

    DEFF Research Database (Denmark)

    Boesen, Lars; Nørgaard, Nis; Løgager, Vibeke

    2017-01-01

    + 3) cancers (14/64 vs. 41/74) and more patients with intermediate/high-grade cancers (GS ≥3 + 4) (50/64 vs. 33/74) using fewer biopsy cores compared with TRUS-bx (p targeted-only" approach in men with PI-RADS ≥3 lesions reduced the number of men requiring repeated biopsies......INTRODUCTION: The aim of the study was to compare the prostate cancer (PCa) detection rate of systematic transrectal ultrasound-guided biopsies (TRUS-bx) and multiparametric-MRI targeted biopsies (mp-MRI-bx) in a repeat biopsy setting and evaluate the clinical significance following an "MRI-targeted...... by 50%, decreased low-grade cancer diagnoses by 66%, and increased intermediate/high-grade cancer diagnoses by 52%. CONCLUSIONS: MRI-targeted biopsies have a high detection rate for significant PCa in patients with prior negative transrectal ultrasound-guided biopsies and preferentially detect...

  17. Reconstrucción con aloprótesis de rodilla por navegación: reporte de un caso

    OpenAIRE

    Pereira Carlos; Matson Gustavo; Rivera Edgardo

    2011-01-01

    CASO CLÍNICO: paciente femenina de 44 años, que vive en zona urbana, actividad casera y de peso promedio para su talla. Presentómasa en 1/3 proximal de la tibia derecha de 8 meses de evolución, diagnosticándose tumor de células gigantes, manejado concuretaje óseo simple y colocación de injertos óseo autólogo, presentando recaída a los 6 meses. Radiológicamente se observaimagen osteolítica, metaepifisiaria en estadio III de Campanacci. Se confirma diagnóstico con biopsia y se decide llevar a c...

  18. Biopsia yeyunal transendoscópica con cápsula de Watson: opción rápida, segura y eficaz en pediatría

    National Research Council Canada - National Science Library

    Martínez Cardet, Luis Francisco; Moreno Díaz, Horacio; Martínez Nieves, Yudamis; Gil Rodríguez, María; Benítez Martínez, Fátima; Cubero Menéndez, Osiris

    2006-01-01

    ... en niños, por lo que se decidió aplicar en pediatría y determinar la utilidad del método, teniendo en cuenta las posibles complicaciones del procedimiento, el tiempo y la eficacia del método...

  19. Two-micrometer thulium laser resection of the prostate-tangerine technique in benign prostatic hyperplasia patients with previously negative transrectal prostate biopsy.

    Science.gov (United States)

    Zhuo, Jian; Wei, Hai-Bin; Zhang, Fei; Liu, Hai-Tao; Zhao, Fu-Jun; Han, Bang-Min; Sun, Xiao-Wen; Xia, Shu-Jie

    2017-01-01

    The 2-μm thulium laser resection of the prostate-tangerine technique (TmLRP-TT) has been introduced as a minimally invasive treatment for benign prostatic hyperplasia (BPH). This study was undertaken to assess the clinical efficacy and safety of TmLRP-TT for the treatment of BPH patients with previously negative transrectal prostate biopsy. A prospective analysis of 51 patients with previously negative transrectal prostate biopsy who underwent surgical treatment using TmLRP-TT was performed from December 2011 to December 2013. Preoperative status, surgical details, and perioperative complications were recorded. The follow-up outcome was evaluated with subjective and objective tests at 1 and 6 months. TmLRP-TT was successfully completed in all patients. Mean prostate volume, operative duration, and catheterization time were 93.3 ± 37.9 ml, 69.5 ± 39.5 min, and 6.5 ± 1.3 days, respectively. The mean International Prostate Symptom Score, quality of life score, maximum urinary flow rate, and post-void residual urine volume changed notably at 6-month follow-up (22.5 ± 6.9 vs 6.1 ± 3.2, 4.8 ± 1.3 vs 1.1 ± 0.9, 7.3 ± 4.5 vs 18.9 ± 7.1 ml s-1 , and 148.7 ± 168.7 vs 28.4 ± 17.9 ml). Two (3.9%) patients required blood transfusion perioperatively, while 3 (5.9%) patients experienced transient hematuria postoperatively, and 2 (3.9%) patients received 3 days recatheterization due to clot retention. TmLRP-TT is a safe and effective minimally invasive technique for patients with previously negative transrectal prostate biopsy during the 6-month follow-up. This promising technology may be a feasible surgical method for previously negative transrectal prostate biopsy in the future.

  20. Correlation of transrectal and transabodominal ultrasound measurement of transition zone volume with post-operative enucleated adenoma volume in benign prostatic hypertrophy.

    Science.gov (United States)

    Ajayi, Idowu; Aremu, Ademola; Olajide, Abimbola; Bello, Tope; Olajide, Folake; Adetiloye, Victor

    2013-01-01

    Benign prostatic hyperplasia is a common disease of ageing men worldwide. Though transrectal ultrasonography (TRUS) is the standard in most parts of the world in evaluation of benign prostatic hyperplasia (BPH), it is rarely done in some less developed countries because of non availability of appropriate probes and or specialists. Transabdominal ultrasonography (TAUS) remains the mainstay in these areas. Some controversies still exist in literature about the accuracy of TAUS evaluation of prostatic volume in patients with BPH. This study aimed at comparing the transition zone volume estimation of the prostate on transrectal and transabdominal ultrasound with post-operative enucleated adenoma volume in Nigeria patients with BPH and to suggest better predictor of prostate volume in evaluation of BPH. Forty-six (46) patients with lower urinary tract symptoms due to BPH attending the urologic clinic were evaluated ultrasonographically and eventually managed with open surgery (prostatectomy) after due counselling. The post operative samples were weighted using a sensitive top loading weighing balance and converted to volume. Since the specific gravity of the prostate is equivalent to that of water,the weight is the same as volume. Patients' ages ranged between 59 and 90 years with a peak age incidence at seventh decade. Transition Zone (TZ) volume estimation on both transrectal and transabdominal ultrasound showed positive correlation with the post operative enucleated adenoma(r = 0.594, p < 0.001) but the transrectal method was more accurate. There was no significant relationship between the TZ volume and patients' symptoms(r = 0.491, p = 0.007). Both TRUS and TAUS are comparable at TZ volume estimation and therefore TAUS can be utilized in regions where intracavitary probes and or the expertise is/are not available.

  1. Caracterización de los tumores testiculares de células germinales según biopsias del servicio de patología. Hospital México, Costa Rica: enero 2003 a marzo 2011 Description of testicular germ cell tumors, according to biopsies from the department of pathology, Mexico Hospital, Costa Rica from january 2003 to march 2011

    Directory of Open Access Journals (Sweden)

    Julia Freer-Vargas

    2013-03-01

    Full Text Available Justificación y objetivo: el 95% de los tumores testiculares son de células germinales. La presencia de estas neoplasias ha venido en aumento, y se han hecho más frecuentes en gente jóven. Los tumores testiculares de células germinales se dividen en dos grupos: seminomatosos y no seminomatosos. El objetivo fue caracterizar los con base en los resultados de biopsia del Patología del Hospital México, del 1º de enero del 2003, al 31 de marzo del 2011. Métodos: estudio descriptivo de una base de datos del servicio de Patología, en donde se seleccionaron los tumores testiculares de células germinales. En el análisis, se calcularon frecuencias absolutas, relativas, intervalos de confianza, medidas de dispersión y de tendencia central y Chi cuadrado pBackground: 95% of testicular tumors are germ cell tumors (TGCT. These neoplasms have increased in number and have become more common in young people. The TGCTs are divided into two groups: seminomatous and non-seminomatous. The objective is to describe the TGCT based on pathological biopsy results at the Mexico hospital from 1st january 2003 to 31st march 2011. Methods: A descriptive study of the department of Pathology database, from which the cases of TGCTs were selected. Within the analysis, absolute and relative frequencies, confidence intervals, measures of dispersion and central tendency were calculated. Chi-square p <0.05 was used for the trend. Results: 148 patients with germ cell tumors were selected. There was an increasing tendency in tumors with p <0.003. Out of the total number of cases, 60.2% (89, CI 95% (52.2-68.1, occurred in males younger than thirty years old. Non-seminomatous TGCTs occurred in 59.5% (88 of the cases, CI 95% (51.5-67.3. The average age of those with non-seminoma was 26.4 years; DE 8.1, and of those with seminoma was 31 years; DE 7.5, with a difference of p <0.001. Conclusions: There is a significant tendency towards the increase of TGCT, which is more

  2. Transrectal rigid-hybrid NOTES cholecystectomy can be performed without peritoneal contamination: a controlled porcine survival study.

    Science.gov (United States)

    Müller, Philip C; Senft, Jonas D; Gath, Philip; Steinemann, Daniel C; Nickel, Felix; Billeter, Adrian T; Müller-Stich, Beat P; Linke, Georg R

    2017-08-10

    The risk of infectious complications due to peritoneal contamination is a major concern and inhibits the widespread use of transrectal NOTES. A standardized rectal washout with a reversible colon occlusion device in situ has previously shown potential in reducing peritoneal contamination. The aim of this study was to compare the peritoneal contamination rate and inflammatory reaction for transrectal cholecystectomy after ideal rectal preparation (trCCE) and standard laparoscopic cholecystectomy (lapCCE) in a porcine survival experiment. Twenty pigs were randomized to trCCE (n = 10) or lapCCE (n = 10). Before trCCE, rectal washout was performed with saline solution. A colon occlusion device was then inserted and a second washout with povidone-iodine was performed. The perioperative course and the inflammatory reaction (leukocytes, C-reactive protein) were compared. At necropsy, 14 days after surgery the abdominal cavity was screened for infectious complications and peritoneal swabs were obtained for comparison of peritoneal contamination. Peritoneal contamination was lower after trCCE than after lapCCE (0/10 vs. 6/10; p = 0.003). No infectious complications were found at necropsy in either group and postoperative complications did not differ (p = 1.0). Immediately after the procedure, leukocytes were higher after lapCCE (17.0 ± 2.7 vs. 14.6 ± 2.3; p = 0.047). Leukocytes and C-reactive protein showed no difference in the further postoperative course. Intraoperative complications and total operation time (trCCE 114 ± 32 vs. 111 ± 27 min; p = 0.921) did not differ, but wound closure took longer for trCCE (31.5 ± 19 vs. 13 ± 5 min; p = 0.002). After standardized rectal washout with a colon occlusion device in situ, trCCE was associated without peritoneal contamination and without access-related infectious complications. Based on the findings of this study, a randomized controlled clinical study comparing clinical outcomes of trCCE with

  3. Usefulness of transrectal ultrasound-guided 12 core biopsy method in patients with clinically suspected prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Se Hwan; Lim, Joo Won; Park, Seong Jin; Ko, Young Tae; Kim, Yoon Wha [Kyung Hee University Hospital, Seoul (Korea, Republic of)

    2000-06-15

    To evaluate the improvement of prostate cancer detection provided by transrectal ultrasound (TRUS)-guided 12 core biopsy method compared with sextant biopsy method. Between June 1997 and February 1999, 29 patients with pathologically proven prostate cancer in 124 patients who underwent TRUS-guided 12 core biopsy method were evaluated. They had abnormal findings in prostate specific antigen (PSA), digital rectal examination (DRE) or TRUS findings. The prostate was diffusely enlarged in all patients on DRE findings and in 15 cases (15/29, 52%), hard nodule was palpated. The average of PSA and prostate specific antigen density (PSAD) is 229.33 ng/ml (1-2280) and 9.14 ng/ml/cm{sup 3} (0.048-142.5), respectively, 12 transrectal biopsy, including 2 transition zones, was performed in both lobe, 6 biopsies were located in both base, middle and apex. Then 2 biopsies were inserted between 3 biopsies in both peripheral zone and 2 biopsies were performed in both transition zone. Each specimen was pathologically examined. The results of pathology were compared with method 1 and 2, respectively. We defined the method 1 and 2 as different sextant biopsy method. The method 1 is that cores are taken from both base, middle and apex and method 2 is that cores are taken from both base, apex and transition zone. TRUS findings were analyzed by two radiologists. Of the 29 patients with prostate cancer, 3 (10%) had carcinomas only in the additional regions as compared with method. When compared with method 2,2 (7.0%) had carcinomas only in the additional regions. 2 patients were same in both cases. TRUS findings were abnormal in 21 cases in all patients whose 12 biopsy method was not helpful. 12 biopsy method was helpful in 2/8 (25%) whose TRUS findings were non-specific and 1/21 (4.8%) whose TRUS findings were abnormal. Small low echoic lesion was seen in one patients whose 12 biopsy method was helpful, but cancer was found in other area. TRUS-guided 12 core biopsy method may be superior

  4. EVALUACIÓN DE DOS MÉTODOS DE EXTRACCIÓN DE ADN A PARTIR DE BIOPSIAS FIJADAS EN FORMALINA Y EMBEBIDAS EN PARAFINA EN CONDICIONES NO ÓPTIMAS Evaluation of Two Methods DNA Extraction from Formalin-Fixed, Paraffin-Embedded Tissues on Non-Optimal Conditions

    Directory of Open Access Journals (Sweden)

    JAVIER ANDRÉS BUSTAMANTE

    2011-08-01

    Full Text Available Los tejidos de archivo son material de incalculable valor para estudios retrospectivos que requieran la aplicación de análisis moleculares. Existen múltiples métodos de extracción de ADN a partir de este tipo de muestras. No obstante, la mayoría de métodos toman mucho tiempo y los reactivos empleados contribuyen a la fragmentación del ADN. Con el objetivo de optimizar dos métodos de extracción de ADN a partir de tejidos embebidos en parafina en condiciones no óptimas, se seleccionaron 47 bloques en parafina que contenían biopsias de pleura, pulmón y pericardio correspondientes a 24 pacientes (66,6% hombres mayores de 18 años, con inflamación granulomatosa crónica, remitidos al Departamento de Patología, Hospital Universitario del Valle entre 2002 y 2007. Se realizaron 10 cortes a cada muestra y se sometieron a dos métodos de extracción de ADN: 1. convencional y 2. QIAamp-DNA mini kit®. La eficiencia del ADN fue valorada por espectrofotometría y amplificación del gen GAPDH. La concentración de ADN de las muestras extraídas por el método convencional fue de 65,52 ng/µL ±11,47 (promedio ± EE y la relación 260/280 varió entre 0,52 y 2,30. De las muestras extraídas por el método comercial, la concentración media de ADN fue 60,89 ng/µL ± 6,02, con una absorbancia que osciló entre 0 y 2,64. El ADN obtenido fue sometido a PCR, de 47 muestras extraídas por ambos métodos, 25 y 23 respectivamente amplificaron exitosamente el gen GAPDH. Los métodos usados para la obtención de ADN presentaron un desempeño similar, revelando así su potencial utilidad en estudios retrospectivos a partir de biopsias embebidas en parafina en condiciones inadecuadas.Paraffin wax embedded tissues are an invaluable material for retrospective studies requiring the application of molecular analysis. Multiple methods are available to extract DNA from these kind of samples. However, the most common methods are slow and the reagents often

  5. The Rectal Administration of Lignocaine Gel and Periprostatic Lignocaine Infiltration During Transrectal Ultrasound-Guided Prostate Biopsy Provides Effective Analgesia

    Science.gov (United States)

    Siddiqui, EJ; Ali, S; Koneru, S

    2006-01-01

    INTRODUCTION Transrectal ultrasound guided prostate needle biopsy (TRUS) is the standard procedure to diagnose or exclude prostate cancer. This procedure can be associated with significant discomfort, both on insertion of the ultrasound probe as well as on taking the biopsy. We evaluated a new technique for pain relief during TRUS biopsy. PATIENTS AND METHODS In Group 1 (n = 60), the biopsies were taken without any analgesia. In Group 2 (n = 60), 11 ml of Instillagel (2% lignocaine) was administered rectally prior to probe insertion and 5 ml of 1% lignocaine periprostatic injection was administered before taking the biopsy. The discomfort encountered during the procedure was graded by the patient on a scale ranging from no discomfort to mild, moderate and severe pain. RESULTS In Group 2, there was a marked reduction in the pain experienced during the procedure. The Chi-squared test for trend showed a significant association between the rectal administration of local anaesthetic gel and reduction in pain on probe insertion (P = 0.0001). There was also a significant association between the use of periprostatic lignocaine injection and reduction in pain on taking the biopsy (P < 0.0001). CONCLUSIONS The use of lignocaine gel prior to probe insertion and periprostatic infiltration of lignocaine before taking the needle biopsy significantly reduces the pain experienced by the patient during TRUS-guided prostate biopsy. PMID:16551424

  6. 3D non-rigid registration using surface and local salient features for transrectal ultrasound image-guided prostate biopsy

    Science.gov (United States)

    Yang, Xiaofeng; Akbari, Hamed; Halig, Luma; Fei, Baowei

    2011-03-01

    We present a 3D non-rigid registration algorithm for the potential use in combining PET/CT and transrectal ultrasound (TRUS) images for targeted prostate biopsy. Our registration is a hybrid approach that simultaneously optimizes the similarities from point-based registration and volume matching methods. The 3D registration is obtained by minimizing the distances of corresponding points at the surface and within the prostate and by maximizing the overlap ratio of the bladder neck on both images. The hybrid approach not only capture deformation at the prostate surface and internal landmarks but also the deformation at the bladder neck regions. The registration uses a soft assignment and deterministic annealing process. The correspondences are iteratively established in a fuzzy-to-deterministic approach. B-splines are used to generate a smooth non-rigid spatial transformation. In this study, we tested our registration with pre- and postbiopsy TRUS images of the same patients. Registration accuracy is evaluated using manual defined anatomic landmarks, i.e. calcification. The root-mean-squared (RMS) of the difference image between the reference and floating images was decreased by 62.6+/-9.1% after registration. The mean target registration error (TRE) was 0.88+/-0.16 mm, i.e. less than 3 voxels with a voxel size of 0.38×0.38×0.38 mm3 for all five patients. The experimental results demonstrate the robustness and accuracy of the 3D non-rigid registration algorithm.

  7. Sperm DNA fragmentation and morphological degeneration in chilled elephant (Elephas maximus and Loxodonta Africana) semen collected by transrectal massage.

    Science.gov (United States)

    O'Brien, J K; Steinman, K J; Montano, G A; Love, C C; Robeck, T R

    2013-05-01

    Ejaculates from nine Asian and two African elephants were analysed to gain a further understanding of mechanisms underlying variable semen quality after transrectal massage. Semen analysis was performed after collection (0 h; subjective motility parameters only) and after 24 h of chilled storage at 10 °C (24 h; all ejaculate and sperm characteristics). Ejaculates with ≤50% total motility (TM) at 24 h, which represented >90% of collection attempts, contained a sperm population with a high degree of DNA damage (64.2 ± 19.2% fragmented DNA) and an elevated incidence of detached heads (43.3 ± 22.5%). In contrast, good quality ejaculates designated as those with >50% TM at 24 h displayed higher (p < 0.05) values of sperm kinetic parameters, DNA integrity and normal morphology. Fertility potential was high for good quality ejaculates from two males (one Asian and one African bull) based on in vitro characteristics after chilled storage for up to 48 h post-collection. Urine contamination of semen, as assessed quantitatively by creatinine concentration, was confirmed as a significant factor in reduced elephant ejaculate quality. However, the identification of considerable DNA damage and morphological degeneration in the majority of ejaculates after only 24 h of chilled storage indicates that sperm ageing could be a primary contributor to inconsistent semen quality in the elephant.

  8. Transrectal microwave thermotherapy causing a short-time influence on sperm quality in Chinese chronic nonbacterial prostatitis patients.

    Science.gov (United States)

    Jin, Jia-Xin; Wang, Han-Zhang; Zhai, Zheng-Xing; Ma, Bao-Liang; Li, Qin-Fang; Xiao, Nan; Wang, Zhi-Ping; Rodriguez, Ronald

    2016-08-19

    Chronic prostatitis can affect the sperm's quality. Previous studies have shown that transrectal microwave thermotherapy (TRMT) results in symptomatic relief in patients with chronic prostatitis, but the effects on sperm have not been carefully investigated. This study evaluates the impact of TRMT on the relief or decrease of symptoms and quality of sperm when used to treat patients with chronic nonbacterial prostatitis. Sixty patients were enrolled in the study. TRMT treatment was administered over 5 days, 1 h per day. Semen examination was carried out pretreatment and immediately at the conclusion of the 5-day treatment. Also, it was repeated 1 month, 3 months, and 6 months later. The treatment's symptom relief efficacy was evaluated using the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI). After the treatment, the overall NIH-CPSI scores were lower compared to those of pretreatment. In addition, the white blood cells and lecithin in expressed prostatic secretion were normal after the treatment. The sperm count was decreased by 23.8% 3 months after the treatment, sperm motility was reduced by 10.3% immediately after treatment, and sperm deformity was increased by 17.2%. The sperm volume and PH were not affected. However, the sperm quality recovered after treatment and the malformation rate was also lower at 6 months after treatment. TRMT is a favorable and safe treatment option for patients with nonbacterial chronic prostatitis. It could relieve the patient's symptoms and impact on sperm quality in the short-term.

  9. The effect of noise-cancelling headphones or music on pain perception and anxiety in men undergoing transrectal prostate biopsy.

    Science.gov (United States)

    Tsivian, Matvey; Qi, Peter; Kimura, Masaki; Chen, Valerie H; Chen, Stephanie H; Gan, Tong J; Polascik, Thomas J

    2012-01-01

    To assess the effect of noise-cancelling headphones with or without music on patient pain and anxiety associated with routine, office-based transrectal ultrasound (TRUS)-guided prostate biopsy in a prospective randomized study. Patients scheduled for prostate biopsy as a result of elevated prostate-specific antigen and/or abnormal digital rectal examination were prospectively enrolled and randomized into a control, noise-cancelling headphones, or music-headphones group. Patients completed pain and anxiety questionnaires and had their physiological parameters assessed before and after the procedure and compared across groups. Eighty-eight patients were enrolled. Pain scores increased from baseline across all study groups, with the lowest mean score in the music group. No appreciable change was noted in anxiety scores after the procedure between groups (P>.05). Although postbiopsy systolic blood pressure values remained comparable with baseline levels in all groups, postbiopsy diastolic blood pressure increased in the control and headphones groups (P=.062 and .088, respectively) but remained stable in the music group (P=.552) after biopsy, indicating lesser physiological response to anxiety and pain in this group. Music-induced attention shift during prostate biopsy may have a beneficial impact on procedural anxiety and pain perception, but no apparent effect was noted for use of headphones alone. Further studies are necessary to explore strategies to reduce perceived anxiety and pain in men undergoing prostate biopsy. Copyright © 2012 Elsevier Inc. All rights reserved.

  10. Sedation as an alternative method to lessen patient discomfort due to transrectal ultrasonography-guided prostate biopsy

    Energy Technology Data Exchange (ETDEWEB)

    Turgut, A.T. [Department of Radiology, Ankara Training and Research Hospital, Ministry of Health, TR-06590 Ankara (Turkey)]. E-mail: ahmettuncayturgut@yahoo.com; Ergun, E. [Department of Radiology, Ankara Training and Research Hospital, Ministry of Health, TR-06590 Ankara (Turkey); Kosar, U. [Department of Radiology, Ankara Training and Research Hospital, Ministry of Health, TR-06590 Ankara (Turkey); Kosar, P. [Department of Radiology, Ankara Training and Research Hospital, Ministry of Health, TR-06590 Ankara (Turkey); Ozcan, A. [Department of Anesthesiology and Reanimation, Ankara Training and Research Hospital, Ministry of Health, TR-06590 Ankara (Turkey)

    2006-01-15

    Background: Despite being highly efficient for the relief of patient discomfort due to transrectal ultrasound (TRUS) guided prostate biopsy, periprostatic anesthesia is occasionally reported to be of limited use. We aimed to evaluate the efficacy of conscious sedation, an accepted method for lessening patient discomfort due to interventional radiological procedures and compare it with periprostatic anesthesia. Methods: 93 candidates for biopsy were randomised to three groups: group 1 (n = 31) received intravenous midazolam, group 2 (n = 31) received periprostatic lidocaine injection, whereas group 3 (n = 31) received no anesthetic before the procedure. After the biopsy patients were asked to express discomfort by visual anologue scale (VAS). Results: The mean scores for groups 1 and 2 were significantly lower than that of group 3 (1.4 {+-} 1.1 and 2.0 {+-} 1.5 versus 4.7 {+-} 1.6, respectively; p < 0.05 for both). For patients with VAS scores exceeding 4 (moderate to severe discomfort), a significant difference was calculated between groups 1 and 2 (3% versus 29%, p < 0.05) and between each and group 3 (3% and 29% versus 80%, respectively; p < 0.05 for each). Conclusions: Sedation is an alternative for increasing patient comfort during TRUS-guided prostate biopsy, especially in clinical situations like patient anxiety, young age, repeat biopsies or inflammatory anal diseases.

  11. [Pain during transrectal ultrasound guided needle biopsy of the prostate: comparison of the use or not of lidocaine gel].

    Science.gov (United States)

    Díaz Pérez, Gilmer A; Meza Montoya, Luis; Morante Deza, Carlos; Pow-Sang Godoy, Mariela; Destefano Urrutia, Víctor

    2009-02-01

    The prostate biopsy guided by ultrasound is the method of choice for early diagnosis of prostate cancer, is a safe whose main trouble is that it feels discomfort during the procedure. From July 2004 until March 2005 we prospectively studied 114 patients who underwent transrectal ultrasound guided needle biopsy of the prostate, they were divided in two groups: in one group we used lidocaina gel 2% inside the rectum before the procedure and in the other group we did not use it. We compared the pain that patients felt during the procedure with a pain scale. We did not find differences between both groups, but the patients in whom we used a new needle felt less pain than the patients in whom we used a re-esterilized one. The use of lidocaine gel intrarectal 2% before a prostate biopsy guided by ultrasound did not diminish the sensation of pain from the procedure in our patients, which was increased by the use of sterilized needles.

  12. Intrarectal ice application prior to transrectal prostate biopsy: a prospective randomised trial accessing pain and collateral effects

    Directory of Open Access Journals (Sweden)

    Baris Çaliskan

    2015-02-01

    Full Text Available Objectives To analyze the efficacy of intrarectal ice application as an anesthetic method prior to transrectal ultrasound (TRUS guided prostate biopsy. Materials and Methods A total of 120 consecutive men were included into the study prospectively. Patients were equally randomized as group 1 and 2 with 60 patients each. Ice was applied as an anesthetic method 5 minutes before procedure to the patients in group 1. Patients in group 2 were applied 10 ml of 2% lidocaine gel 10 minutes before procedure. Twelve core biopsy procedure was performed for all patients. The pain level was evaluated using a visual analogue scale (VAS. Results Median pain score was 3.5 (1-8 in group 1 and 5 (1-8 in group 2. There is significantly difference between groups regarding the mean sense of pain level during the procedure. (p=0.007 There was also no difference in complications between two groups about presence and duration of macroscopic hematuria and rectal bleeding. Conclusions Intrarectal ice application prior to TRUS prostate biopsy has an effect on reducing pain. Development of new techniques about cold effect or ice can make this method more useful and decrease complication rates.

  13. Simple Use of the Suppository Type Povidone-Iodine Can Prevent Infectious Complications in Transrectal Ultrasound-Guided Prostate Biopsy

    Directory of Open Access Journals (Sweden)

    Dong Soo Park

    2009-01-01

    Full Text Available Purpose. To determine the effect of simple use of suppository povidone-iodine on infectious complications after transrectal ultrasonography-guided biopsy of the prostate. Methods. All 481 patients are included and received antibiotic prophylaxis. Among them, 360 patients received povidone-iodine suppository (Gynobetadine; 200 mg immediately prior to biopsy and 121 patients did not. Infectious complications were classified. To evaluate bactericidal effects, we counted bacterial colonies in the rectum, harvested from a rectal swab before insertion of the suppository and after biopsy. Aliquots of the suspended bacterial strains were added to Mueller-Hinton agar medium for incubation. Colony counts were determined. Results. Infectious complications developed in 1 case (0.3% in the rectal preparation group (Group 1 and in 8 cases (6.6% in the nonrectal preparation group (Group 2. One in Group 1 had a fever without sepsis. Two patients had sepsis and six had fever without sepsis in Group 2. Rectal preparation was a statistically significant risk factor influencing the development of infectious complications. In vitro experiments, the mean number of colony-forming units decreased 99.9% after the rectal povidone-iodine preparation. Conclusions. All through the biopsy, povidone-iodine melted into the rectum and decreased the bacterial colony count. Simple use of povidone-iodine suppository before prostate biopsy minimizes the risk of infectious complications.

  14. Lidocaine suppository for transrectal ultrasound-guided biopsy of the prostate: a prospective, double-blind, randomized study.

    Science.gov (United States)

    Goluza, Eleonora; Hudolin, Tvrtko; Kastelan, Zeljko; Peric, Mladen; Murselovic, Tamara; Sosic, Hrvoje

    2011-01-01

    To investigate analgesia using lidocaine suppositories for prostate biopsy. From 2007 to 2009, 160 patients underwent transrectal ultrasound-guided prostate biopsy at the Department of Urology, KBC Zagreb. 80 patients received a 60-mg lidocaine suppository intrarectally at different time points from 15 to 120 min before biopsy and 80 patients received a glycerin suppository as placebo. The pain level was evaluated using a visual analogue scale (VAS). There were no statistically significant differences between the groups, i.e. they were similar regarding patients' age, prostate-specific antigen levels, prostate volume and the incidence of diagnosis of malignancy on biopsy. The mean pain score in the lidocaine group (3 ± 1) was significantly lower than the mean pain score in the glycerin group (4.1 ± 1.3) (p suppository till the biopsy and the optimal time for performing biopsy starting approximately 1 h after placing the suppository. Lidocaine suppositories are an easy-to-use, self-applicable (by the patient) and cheap method of local analgesia, with acceptable results. Possible complications related to this procedure are insignificant. Copyright © 2011 S. Karger AG, Basel.

  15. Arteterapia con personas con discapacidad intelectual

    OpenAIRE

    Lorenzo Pipkau, Milena

    2015-01-01

    Este proyecto pretende hacer una aproximaci??n al mundo del Arte Terapia y los beneficios que esta disciplina puede aportar a las personas con discapacidad intelectual. La idea surge de la experiencia previa de la autora en este ??mbito y con este colectivo. A trav??s de la documentaci??n bibliogr??fica se busca ampliar el conocimiento en cuanto al concepto de arteterapia y sus antecedentes, con la finalidad de elaborar una propuesta pr??ctica que se basar?? en el dise??o de un taller de arte...

  16. Miocarditis de células gigantes con bloqueo AV completo persistente: respuesta al tratamiento con resincronizador cardiaco Giant cell myocarditis with complete persistent A-V block: treatment response with cardiac resynchronization

    Directory of Open Access Journals (Sweden)

    Julián Aristizábal

    2009-08-01

    Full Text Available La miocarditis de células gigantes es una enfermedad grave y poco frecuente, cuya etiología, posiblemente autoinmune, se caracteriza por la presencia de células gigantes multinucleadas con infiltrado inflamatorio y necrosis extensa en la biopsia endomiocárdica. Es común su asociación con taquicardias ventriculares y con alteraciones de la conducción aurículo-ventricular, lo cual se resuelve algunas veces con tratamiento inmunosupresor. Dada la complejidad del pronóstico de esta entidad, el papel de los dispositivos de resincronización después de la estabilización de la falla cardíaca, no está claro. Aquí se reporta un caso en el cual el implante de uno de estos dispositivos fue parte fundamental de la terapia y recuperación del paciente.Giant cell myocarditis is an infrequent and serious illness, possibly of autoimmune etiology, characterized by the presence of multinucleated giant cells with inflammatory infiltrate and extensive necrosis in the endomyocardial biopsy. Its association with ventricular tachycardia is common and alterations in atrioventricular conduction are frequently solved through immunosuppressive treatment. Given the generally complex prognosis of this entity, the role of the resynchronization devices after the heart failure stabilization, is unclear. We reported a case in which the implant of one of these devices was a fundamental part of the therapy and patient recovery.

  17. Validación del Protocolo para el Estudio de la Hemorragia Uterina Anormal con Ecografía endovaginal y medio de Contraste (Sonohisterografía.

    Directory of Open Access Journals (Sweden)

    Ricardo Rueda Saenz

    2003-08-01

    Full Text Available

    La evaluación del sangrado uterino anormal (SUA especialmente en los años postreproductivos, convencionalmente se hace recurriendo a las biopsias y aspiraciones endometriales ciegas en el consultorio, o al curetaje uterino bajo anestesia general. Dichos procedimientos, además de ser invasivos, han mostrado ser poco sensibles y específicos en la detección y el tratamiento de la patología focal del endometrio (pólipos, leiomiomas submucosos, y además pueden resultar costosos. Con el advenimiento de la histeroscopia, se han obviado muchas de las dificultades atribuidas a la biopsia ciega y el curetaje uterino, pero aquella, además de requerir un entrenamiento específico y un equipo costoso, requiere de anestesia local o general, en ocasiones dilatación del cervix y en muchas instancias arroja resultados negativos.

    De otro lado, la histeroscopia sólo permite evaluar el canal cervical y la cavidad endometrial, sin poder visualizar la pared miometrial, los anexos y otras estructuras pélvicas, lo cual desvirtúa su uso en una gran proporción de pacientes como investigación inicial rutinaria en el sangrado uterino anormal.

    La utilización de la ecografía transvaginal con contraste líquido (sonohisterografía o histerosonografía permite, por el contrario, no solamente una evaluación precisa y detallada del canal cervical y la cavidad endometrial, sino que permite evaluar la pared miometrial, los ovarios y otras estructuras pélvicas, así como la permeabilidad de las trompas uterinas.

    Este procedimiento tiene además un bajo costo, no requiere de entrenamiento especial, tampoco de anestesia ni de dilatación cervical y tiene bajas tasas de complicaciones. Con la sonohisterografía se pueden seleccionar en forma eficiente y rápida, las mujeres que realmente se benefician de una histeroscopia diagnóstica-operatoria o de una biopsia endometrial ciega de consultorio para evaluar el SUA.

    El presente estudio

  18. Granulomatosis sarcoidea necrosante con compromiso sistémico Necrotizing sarcoid granulomatosis with systemic involvement

    Directory of Open Access Journals (Sweden)

    María Elena Ceballos

    2006-09-01

    Full Text Available Mujer mapuche de 70 años quien en el curso de 1 año presentó baja de peso, ojo rojo bilateral y úlcera corneal que evolucionó hacia la perforación con herniación uveal y pérdida de la visión. Posteriormente se agregaron lesiones nodulares, violáceas, sensibles, algunas ulceradas en las zonas distales de ambas extremidades inferiores. La TAC de tórax demostró múltiples nódulos pulmonares. Tras un estudio exhaustivo se descartaron la tuberculosis y otras infecciones. Tanto la biopsia de las lesiones cutáneas como la biopsia pulmonar obtenida mediante toracotomía confirmaron la presencia de granulomas necrotizantes no caseificantes y arteritis granulomatosa. Se trató con esteroides y ciclofosfamida con mejoría de su condición general y regresión de las lesiones cutáneas y pulmonares en menos de 1 mes. Se realizó un trasplante de cornea. A los seis meses de seguimiento continúa en tratamiento, no ha presentado recaídas y tiene recuperación parcial de la visiónA 70-year-old mapuche female presented with a 1 year history of weight loss, bilateral red painful eyes and corneal ulcer that evolved into perforation and uveal herniation with complete visual loss. Reddish and painful nodules appeared on the distal aspect of both lower extremities, that ulcerated after months. A thoracic CT scan showed multiple pulmonary nodules. Infectious diseases were ruled out. An open lung biopsy and a skin biopsy were performed and both showed non-caseating necrotizing granulomas and granulomatous arteritis. Steroids and cyclophosphamide were started with complete regression of skin and pulmonary lesions within a month. Corneal transplantation was done. After 6 months follow-up, the patient is on low-dose of steroids, free of disease with partial vision recovery

  19. Nefropatía membranosa secundaria a exposición laboral con mercurio metálico

    Directory of Open Access Journals (Sweden)

    Ana Voitzuk

    2014-10-01

    Full Text Available Las nefropatías tóxicas secundarias a la exposición ocupacional a metales han sido ampliamente estudiadas. La nefropatía membranosa por mercurio es poco frecuente.La intoxicación ocupacional con mercurio sí es frecuente, siendo las principales formas de presentación las manifestaciones clínicas neurológicas. La afectación renal secundaria a la exposición crónica a mercurio metálico puede desarrollar enfermedad glomerular por depósito de inmunocomplejos. La glomerulopatía membranosa y a cambios mínimos son las más frecuentemente comunicadas.Se presenta el caso de un paciente con exposición ocupacional a mercurio metálico, con síndrome nefrótico y biopsia renal con glomerulopatía membranosa que presentó respuesta favorable luego del tratamiento quelante e inmunosupresor.

  20. Transjugular liver biopsy: histological diagnosis success comparing the trucut to the modified aspiration Ross needle Biopsia hepática transjugular: comparação do sucesso diagnóstico histológico entre as agulhas trucut e a aspirativa modificada de Ross

    Directory of Open Access Journals (Sweden)

    Antonio Carlos Maciel

    2003-06-01

    Full Text Available BACKGROUND: Transjugular liver biopsy is an alternative procedure for patients who present contraindications to standard percutaneous procedure. AIM: To compare the rate of histological diagnosis obtained on transjugular liver biopsy with an automated trucut needle and with a modified Ross needle. PATIENTS / METHOD: Eighty-five patients with suspicion of chronic liver diseases and presenting contraindications for percutaneous liver biopsy (coagulopathy, massive ascites, morbid obesity, or chronic renal problems were submitted to 89 transjugular liver biopsies between March 1994 and April 2001 at ''Hospital São José, Irmandade da Santa Casa de Misercórdia'', Porto Alegre, RS, Brazil. Thirty-five patients underwent 36 biopsies with an automated trucut needle, and 50 patients underwent 53 biopsies with a modified Ross needle. RESULTS: Histological diagnosis was reached in 32/35 subjects submitted to transjugular liver biopsy with the trucut needle (91% and in 35/50 (70% submitted to biopsy with the modified Ross needle. Specimens obtained with the trucut needle were significantly larger and less fragmented than those obtained with the Ross needle. CONCLUSION: Transjugular liver biopsy with the automated trucut needle allowed a higher rate of histological diagnosis when compared to the modified Ross needle in patients with suspicion of chronic liver diseases.RACIONAL: A biopsia hepática transjugular é um procedimento alternativo para pacientes que apresentam contra-indicações ao procedimento padrão (percutâneo. OBJETIVO: Comparar o índice de diagnóstico obtido por meio da biopsia hepática transjugular utilizando uma agulha automatizada trucut e uma agulha Ross modificada. MÉTODOS: Oitenta e cinco pacientes com suspeita de doenças hepáticas crônicas e apresentando contra-indicações para biopsia hepática percutânea (coagulopatia, ascite maciça, obesidade mórbida ou problemas renais crônicos foram submetidos a 89 biopsias hep

  1. Paciente joven con disfonía: un caso de amiloidosis poco habitual

    Directory of Open Access Journals (Sweden)

    Alicia Maria Aquino Valdovinos

    2015-08-01

    Full Text Available La amiloidosis es una enfermedad caracterizada por el depósito extracelular de fibrillas compuestas por subunidades de bajo peso molecular de una variedad de proteínas. Puede ser clasificada según su distribución y según la proteina fibrilar constituyente. La prevalencia varía según el área geográfica estudiada y el pronóstico depende del tejido u órgano afectado. Presentamos el caso de un varón jóven con disfonía de larga evolución sin otros síntomas acompañantes en cuya nasofibroscopía se observaron una tumoración en regíon laríngea. En la anatomía patológica se observó material hialino congofílico compatible con amiloide. Se realizó además una biopsia rectal donde también se observó material amiloide. Debido a la poca sintomatología y a la ausencia de compromiso de un órgano que comprometa la vida, en este paciente se optó por un manejo conservador.

  2. Linfoma primario del sistema nervioso central en una paciente con lupus eritematoso sistémico

    Directory of Open Access Journals (Sweden)

    C. N. Pisoni

    2003-06-01

    Full Text Available Se presenta una paciente de 36 años con diagnóstico de lupus eritematoso sistémico tratada con prednisona y ciclofosfamida que se internó por cefalea, hemiparesia y hemianestesia braquiocrural derecha de dos semanas de evolución. Se realizó una tomografía computada y una resonancia magnética nuclear de cerebro que mostraron una lesión nodular frontal izquierda. Se efectuó una biopsia a cielo abierto de la lesión cerebral cuyo diagnóstico histopatológico fue linfoma B de celulas grandes, difuso. Se inició radioterapia, no completó el tratamiento por complicaciones y falleció. Son muy pocos los casos publicados de linfoma primario del sistema nervioso central asociado a lupus eritematoso sistémico.A 36 year-old woman with systemic lupus erythematosus was admitted to our hospital with headache, brachiocrural hemiparesis and hemianesthesia. She had been treated with prednisone and cyclophosphamide. CT scan and MRI revealed a 15 mm nodular mass enhanced with gadolinium in left frontal convexity. CNS biopsy was performed and a diffuse large B-cell lymphoma was diagnosed. She was treated with radiation therapy without response and died. There are few reports of erythematosus systemic lupus associated with primary central nervous system lymphoma.

  3. [XPS Greenlight photoselective vaporization for benign prostatic hyperplasia: analysis of the learning curve and contribution of transrectal ultrasound monitoring].

    Science.gov (United States)

    Misrai, V; Faron, M; Elman, B; Bordier, B; Portalez, D; Guillotreau, J

    2013-09-01

    The aim of this study was to analyze the XPS laser learning curve of one single surgeon with no previous experience of PVP and the impact of the use of reel time transrectal ultrasound (TRUS) monitoring. Retrospective analysis of the first 100 patients: group 1 (1st-49th patient without TRUS) and group 2 (50th-100th with TRUS). The learning curve was analyzed through technical variables: vaporization time/intervention time (VT/IT) (%), energy delivered (J)/prostate volume (J/mL) and delivered energy (J/s or Watt), peroperative conversion into monopolar transurethral resection, postoperative complication, duration of catheterization and hospitalization and evolution of International Prostate Symptom Score (IPSS), PSA level, prostate residual volume and Qmax. Relationships between variables were evaluated by analysing the covariance (R 2 software. 14.2). A significant increase in VT/IT (P=0.0001) and the energy delivered per mL prostate (P=0.043) was reported in group 1. The average energy delivered per second was significantly higher in group 2 (P=0.0016). No difference was observed in terms of intra- or postoperative complication and catheterization time. The duration of hospitalization was significantly shorter in group 2 (P=0.03). The use of TRUS was associated with a gain of energy delivered by prostate volume at the end of learning curve (P=0.018). Prostate residual volume was significantly lower in the group 2 (P=0.0004). In our experience, 50 procedures are required to achieve the learning curve of PVP. The use of reel time TRUS would increase the energy delivered by prostate volume. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  4. Factors associated with the differential in actual gestational age and gestational age predicted from transrectal ultrasonography in pregnant dairy cows.

    Science.gov (United States)

    Fitzgerald, A M; Ryan, D P; Berry, D P

    2015-08-01

    The objective of the study was to determine (1) how gestational age predicted using transrectal ultrasonography related to actual gestational age derived as the number of days from the most recent artificial insemination date, (2) what factors, if any, were associated with the differential between the two measures, and (3) the association between this differential in gestational age and the likelihood of subsequent pregnancy loss, stillbirth, or calving dystocia. The data set contained 7340 ultrasound records from 6805 Holstein Friesian dairy cows in 175 herds. Ultrasonography assessment underestimated gestational age relative to days since last service by 0.51 days (standard error [SE]: 0.040), although the differential was less during embryonic development phase (i.e., ≤42 days of gestation; mean overestimation of 0.31 days) versus fetal development phase (i.e., >42 days of gestation; mean underestimation of 0.81 days). Predicted calving date calculated from ultrasonography was 1.41 days (SE: 0.040) later than the actual subsequent calving date and was, on average, 0.52 days later than predicted calving date, assuming a gestation length of 282 days. Parity of the dam (P gestation length. Gestation length was 1.27 days longer (SE: 0.01) for bull calves compared to heifer calves. Calves from beef sires had a longer gestation length than calves from dairy sires, and older parity cows had a longer gestation length than younger cows. The results highlight factors associated with differences in gestational age obtained from ultrasonography and insemination data and illustrate the value of ultrasonography for the prediction of calving date and pregnancy loss.

  5. Transrectal ultrasonography (TRUS)-guided pelvic plexus block to reduce pain during prostate biopsy: a randomised controlled trial.

    Science.gov (United States)

    Jindal, Tarun; Mukherjee, Subhabrata; Sinha, Rajan K; Kamal, Mir R; Ghosh, Nabankur; Saha, Barun; Mitra, Nilanjan; Sharma, Pramod K; Mandal, Soumendra N; Karmakar, Dilip

    2015-06-01

    To assess the role of pelvic plexus block (PPB) in reducing pain during transrectal ultrasonography(TRUS)-guided prostate biopsy, compared with the conventional periprostatic nerve block (PNB). A prospective, double-blind observational study was conducted with patients being randomised into three groups. Group-1 (47 patients) received intrarectal local anaesthesia (IRLA) with 10 mL 2% lignocaine jelly along with pelvic plexus block (PPB) with 2.5 mL 2% lignocaine injection bilaterally. Group-2 (46 patients) received IRLA with periprostatic nerve block (PNB). Group-3 (46 patients) received only IRLA without any type of nerve block. The patients were requested to rate the level of pain from 0 to 10 on a visual analogue scale (VAS) at two time points: VAS-1: during biopsy procedure and VAS-2: 30 min after the procedure. The mean age of the patients, mean volume of the prostates and mean serum PSA values were comparable among the three groups. The mean pain score during biopsy was significantly less in the PPB group [mean (range) sore of 2.91 (2-4)] compared with the PNB group [mean (range) score of 4 (3-5)], and both these groups were superior to the no nerve block group [mean score of 5.4 (3-7)]. There was no significant difference between the mean pain scores, 30 min after the procedure among the three groups with the mean (range) scores being 2.75 (2-4), 2.83 (2-4) and 2.85 (2-4), respectively. PPB is superior to conventional periprostatic nerve block (PNB) for pain control during TRUS-guided biopsy and both are in turn superior to no nerve block. © 2014 The Authors. BJU International © 2014 BJU International.

  6. Classification of Focal Prostatic Lesions on Transrectal Ultrasound (TRUS) and the Accuracy of TRUS to Diagnose Prostate Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Ho Yun [Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Lee, Hak Jong; Byun, Seok Soo; Lee, Sang Eun; Hong, Sung Kyu [Seoul National University Bundang Hospital, Seongnam (Korea, Republic of); Kim, Seung Hyup [Seoul National University Hospital, Seoul (Korea, Republic of)

    2009-06-15

    To improve the diagnostic efficacy of transrectal ultrasound (TRUS)-guided targeted prostatic biopsies, we have suggested the use of a new scoring system for the prediction of malignancies regarding the characteristics of focal suspicious lesions as depicted on TRUS. A total of 350 consecutive patients with or without prostate cancer who underwent targeted biopsies for 358 lesions were included in the study. The data obtained from participants were randomized into two groups; the training set (n = 240) and the test set (n = 118). The characteristics of focal suspicious lesions were evaluated for the training set and the correlation between TRUS findings and the presence of a malignancy was analyzed. Multiple logistic regression analysis was used to identify variables capable of predicting prostatic cancer. A scoring system that used a 5-point scale for better malignancy prediction was determined from the training set. Positive predictive values for malignancy prediction and the diagnostic accuracy of the scored components with the use of receiver operating characteristic curve analysis were evaluated by test set analyses. Subsequent multiple logistic regression analysis determined that shape, margin irregularity, and vascularity were factors significantly and independently associated with the presence of a malignancy. Based on the use of the scoring system for malignancy prediction derived from the significant TRUS findings and the interactions of characteristics, a positive predictive value of 80% was achieved for a score of 4 when applied to the test set. The area under the receiver operating characteristic curve (AUC) for the overall lesion score was 0.81. We have demonstrated that a scoring system for malignancy prediction developed for the characteristics of focal suspicious lesions as depicted on TRUS can help predict the outcome of TRUS-guided biopsies.

  7. Oral antibiotics in trans-rectal prostate biopsy and its efficacy to reduce infectious complications: Systematic review

    Directory of Open Access Journals (Sweden)

    Mohand Deeb Yaghi

    2015-01-01

    Full Text Available For the diagnosis of prostate cancer trans-rectal prostate biopsy (TRPB is used commonly, the procedure is associated with infective complications. There is evidence that antibiotics (ABx decrease infective events after TRPB, but different regimens are used. To systematically review different regimens of prophylactic oral ABx in TRPB. MEDLINE, EMBASE, clinical trials site, and Cochrane library were searched, experts were consulted for relevant studies. Randomized clinical trials conducted in the last 20 years, which investigated the different oral antibiotic regimens in TRPB, and compared their efficacy to reduce infectious complications were analyzed. Primary outcomes were bacteriuria, urinary tract infection (UTI, fever, bacteremia, and sepsis. Secondary outcomes were the hospitalization rate and the prevalence of ABx-resistant bacteria. Nine trials were eligible with 3012 patients. ABx prevented bacteriuria (3.5% vs. 9.88%, UTI (4.46% vs. 9.75%, and hospitalization (0.21% vs. 2.13% significantly in comparison with placebo or no treatment. No significant difference was found in all the outcomes of the review between the single dose regimen and the 3 days. The single dose regimen was as effective as the multiple doses except in bacteriuria (6.75% vs. 3.25%, and the prevalence of ABx-resistant bacteria (1.57% vs. 0.27%. Quinolones reduced only UTI significantly in comparison with other ABx (chloramphenicol, trimethoprim-sulfamethoxazol. It is essential to prescribe prophylactic ABx in TRPB. No conclusive evidence could be claimed about the superiority of the multiple or the 3 days regimens to the single dose regimen. Unexpectedly, ABx-resistant bacteria were identified more often in the single dose cohorts.

  8. Association between Seminal Vesicle Invasion and Prostate Cancer Detection Location after Transrectal Systemic Biopsy among Men Who Underwent Radical Prostatectomy.

    Directory of Open Access Journals (Sweden)

    Young Ik Lee

    Full Text Available Our hypothesis is that the location of the seminal vesicles near the base of the prostate, the more positive cores are detected in the base, the greater the risk of seminal vesicle invasion. Therefore we investigate the clinical outcomes of base dominant prostate cancer (BDPC in transrectal ultrasound (TRUS -guided biopsies compared with anteromiddle dominant prostate cancer (AMPC.From November 2003 to June 2014, a total of 990 intermediate and high risk prostate cancer (PCa patients who underwent radical prostatectomy (RP were enrolled and stratified into two groups according to proportion of positive cores-BDPC group had ≥ 33.3% ratio of positive cores from the prostate base among all positive cores and AMPC group < 33.3% in systemic biopsy. Between two groups, we compared the rate of pathologic outcomes and biochemical recurrence (BCR. We performed multivariate logistic regression model to confirm the significance of BDPC to seminal vesicle invasion (SVI and Cox proportional hazard analysis to BCR.Among these 990 PCa patients, the 487 patients in BDPC group had more advanced clinical stage (p<0.001, a higher biopsy GS (p = 0.002, and a higher rate of extracapsular extension (ECE, SVI and BCR (all p<0.001 than AMPC group. The patients in BDPC group had poor BCR free survival rate via Kaplan-meier analysis (p<0.001. The ratio of the base positive cores was a significant predictor to SVI in multivariate analysis (p < 0.001 and significant predictor of BCR in multivariate Cox proportional analysis (hazard ratio: 1.466, p = 0.004.BDPC in TRUS-guided prostate biopsies was significantly associated with SVI and BCR after adjusting for other clinical factors. Therefore, BDPC should be considered to be a more aggressive tumor despite an otherwise similar cancer profile.

  9. Prostate cancer transrectal HIFU ablation: detection of local recurrences using T2-weighted and dynamic contrast-enhanced MRI

    Energy Technology Data Exchange (ETDEWEB)

    Rouviere, Olivier; Lyonnet, Denis [Hopital Edouard Herriot, Hospices Civils de Lyon, Department of Urinary and Vascular Radiology, Lyon (France); Universite de Lyon, Lyon (France); Universite de Lyon 1, Faculte de medecine Lyon Nord, Lyon (France); Inserm, U556, Lyon (France); Girouin, Nicolas; Glas, Ludivine; Ben Cheikh, Alexandre [Hopital Edouard Herriot, Hospices Civils de Lyon, Department of Urinary and Vascular Radiology, Lyon (France); Universite de Lyon, Lyon (France); Universite de Lyon 1, Faculte de medecine Lyon Nord, Lyon (France); Gelet, Albert [Hopital Edouard Herriot, Hospices Civils de Lyon, Department of Urology, Lyon (France); Inserm, U556, Lyon (France); Mege-Lechevallier, Florence [Hopital Edouard Herriot, Hospices Civils de Lyon, Department of Pathology, Lyon (France); Rabilloud, Muriel [Hospices Civils de Lyon, Department of Biostatistics, Lyon (France); Universite de Lyon 1, UMR CNRS, Laboratoire Biostatistiques-Sante, Pierre-Benite (France); Chapelon, Jean-Yves [Inserm, U556, Lyon (France)

    2010-01-15

    The objective was to evaluate T2-weighted (T2w) and dynamic contrast-enhanced (DCE) MRI in detecting local cancer recurrences after prostate high-intensity focused ultrasound (HIFU) ablation. Fifty-nine patients with biochemical recurrence after prostate HIFU ablation underwent T2-weighted and DCE MRI before transrectal biopsy. For each patient, biopsies were performed by two operators: operator 1 (blinded to MR results) performed random and colour Doppler-guided biopsies (''routine biopsies''); operator 2 obtained up to three cores per suspicious lesion on MRI (''targeted biopsies''). Seventy-seven suspicious lesions were detected on DCE images (n=52), T2w images (n=2) or both (n=23). Forty patients and 41 MR lesions were positive at biopsy. Of the 36 remaining MR lesions, 20 contained viable benign glands. Targeted biopsy detected more cancers than routine biopsy (36 versus 27 patients, p=0.0523). The mean percentages of positive cores per patient and of tumour invasion of the cores were significantly higher for targeted biopsies (p<0.0001). The odds ratios of the probability of finding viable cancer and viable prostate tissue (benign or malignant) at targeted versus routine biopsy were respectively 3.35 (95% CI 3.05-3.64) and 1.38 (95% CI 1.13-1.63). MRI combining T2-weighted and DCE images is a promising method for guiding post-HIFU biopsy towards areas containing recurrent cancer and viable prostate tissue. (orig.)

  10. Documenting the location of systematic transrectal ultrasound-guided prostate biopsies: correlation with multi-parametric MRI

    Science.gov (United States)

    Xu, Sheng; Kruecker, Jochen; Locklin, Julia; Pang, Yuxi; Shah, Vijay; Bernardo, Marcelino; Baccala, Angelo; Rastinehad, Ardeshir; Benjamin, Compton; Merino, Maria J.; Wood, Bradford J.; Choyke, Peter L.; Pinto, Peter A.

    2011-01-01

    Abstract During transrectal ultrasound (TRUS)-guided prostate biopsies, the actual location of the biopsy site is rarely documented. Here, we demonstrate the capability of TRUS-magnetic resonance imaging (MRI) image fusion to document the biopsy site and correlate biopsy results with multi-parametric MRI findings. Fifty consecutive patients (median age 61 years) with a median prostate-specific antigen (PSA) level of 5.8 ng/ml underwent 12-core TRUS-guided biopsy of the prostate. Pre-procedural T2-weighted magnetic resonance images were fused to TRUS. A disposable needle guide with miniature tracking sensors was attached to the TRUS probe to enable fusion with MRI. Real-time TRUS images during biopsy and the corresponding tracking information were recorded. Each biopsy site was superimposed onto the MRI. Each biopsy site was classified as positive or negative for cancer based on the results of each MRI sequence. Sensitivity, specificity, and receiver operating curve (ROC) area under the curve (AUC) values were calculated for multi-parametric MRI. Gleason scores for each multi-parametric MRI pattern were also evaluated. Six hundred and 5 systemic biopsy cores were analyzed in 50 patients, of whom 20 patients had 56 positive cores. MRI identified 34 of 56 positive cores. Overall, sensitivity, specificity, and ROC area values for multi-parametric MRI were 0.607, 0.727, 0.667, respectively. TRUS-MRI fusion after biopsy can be used to document the location of each biopsy site, which can then be correlated with MRI findings. Based on correlation with tracked biopsies, T2-weighted MRI and apparent diffusion coefficient maps derived from diffusion-weighted MRI are the most sensitive sequences, whereas the addition of delayed contrast enhancement MRI and three-dimensional magnetic resonance spectroscopy demonstrated higher specificity consistent with results obtained using radical prostatectomy specimens. PMID:21450548

  11. Combining transrectal ultrasound and CT for image-guided adaptive brachytherapy of cervical cancer: Proof of concept.

    Science.gov (United States)

    Nesvacil, Nicole; Schmid, Maximilian P; Pötter, Richard; Kronreif, Gernot; Kirisits, Christian

    To investigate the feasibility of a treatment planning workflow for three-dimensional image-guided cervix cancer brachytherapy, combining volumetric transrectal ultrasound (TRUS) for target definition with CT for dose optimization to organs at risk (OARs), for settings with no access to MRI. A workflow for TRUS/CT-based volumetric treatment planning was developed, based on a customized system including ultrasound probe, stepper unit, and software for image volume acquisition. A full TRUS/CT-based workflow was simulated in a clinical case and compared with MR- or CT-only delineation. High-risk clinical target volume was delineated on TRUS, and OARs were delineated on CT. Manually defined tandem/ring applicator positions on TRUS and CT were used as a reference for rigid registration of the image volumes. Treatment plan optimization for TRUS target and CT organ volumes was performed and compared to MRI and CT target contours. TRUS/CT-based contouring, applicator reconstruction, image fusion, and treatment planning were feasible, and the full workflow could be successfully demonstrated. The TRUS/CT plan fulfilled all clinical planning aims. Dose-volume histogram evaluation of the TRUS/CT-optimized plan (high-risk clinical target volume D90, OARs D2cm³ for) on different image modalities showed good agreement between dose values reported for TRUS/CT and MRI-only reference contours and large deviations for CT-only target parameters. A TRUS/CT-based workflow for full three-dimensional image-guided cervix brachytherapy treatment planning seems feasible and may be clinically comparable to MRI-based treatment planning. Further development to solve challenges with applicator definition in the TRUS volume is required before systematic applicability of this workflow. Copyright © 2016 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

  12. Fully automatic prostate segmentation from transrectal ultrasound images based on radial bas-relief initialization and slice-based propagation.

    Science.gov (United States)

    Yu, Yanyan; Chen, Yimin; Chiu, Bernard

    2016-07-01

    Prostate segmentation from transrectal ultrasound (TRUS) images plays an important role in the diagnosis and treatment planning of prostate cancer. In this paper, a fully automatic slice-based segmentation method was developed to segment TRUS prostate images. The initial prostate contour was determined using a novel method based on the radial bas-relief (RBR) method, and a false edge removal algorithm proposed here in. 2D slice-based propagation was used in which the contour on each image slice was deformed using a level-set evolution model, which was driven by edge-based and region-based energy fields generated by dyadic wavelet transform. The optimized contour on an image slice propagated to the adjacent slice, and subsequently deformed using the level-set model. The propagation continued until all image slices were segmented. To determine the initial slice where the propagation began, the initial prostate contour was deformed individually on each transverse image. A method was developed to self-assess the accuracy of the deformed contour based on the average image intensity inside and outside of the contour. The transverse image on which highest accuracy was attained was chosen to be the initial slice for the propagation process. Evaluation was performed for 336 transverse images from 15 prostates that include images acquired at mid-gland, base and apex regions of the prostates. The average mean absolute difference (MAD) between algorithm and manual segmentations was 0.79±0.26mm, which is comparable to results produced by previously published semi-automatic segmentation methods. Statistical evaluation shows that accurate segmentation was not only obtained at the mid-gland, but also at the base and apex regions.

  13. Three-dimensional nonrigid landmark-based magnetic resonance to transrectal ultrasound registration for image-guided prostate biopsy.

    Science.gov (United States)

    Sun, Yue; Qiu, Wu; Yuan, Jing; Romagnoli, Cesare; Fenster, Aaron

    2015-04-01

    Registration of three-dimensional (3-D) magnetic resonance (MR) to 3-D transrectal ultrasound (TRUS) prostate images is an important step in the planning and guidance of 3-D TRUS guided prostate biopsy. In order to accurately and efficiently perform the registration, a nonrigid landmark-based registration method is required to account for the different deformations of the prostate when using these two modalities. We describe a nonrigid landmark-based method for registration of 3-D TRUS to MR prostate images. The landmark-based registration method first makes use of an initial rigid registration of 3-D MR to 3-D TRUS images using six manually placed approximately corresponding landmarks in each image. Following manual initialization, the two prostate surfaces are segmented from 3-D MR and TRUS images and then nonrigidly registered using the following steps: (1) rotationally reslicing corresponding segmented prostate surfaces from both 3-D MR and TRUS images around a specified axis, (2) an approach to find point correspondences on the surfaces of the segmented surfaces, and (3) deformation of the surface of the prostate in the MR image to match the surface of the prostate in the 3-D TRUS image and the interior using a thin-plate spline algorithm. The registration accuracy was evaluated using 17 patient prostate MR and 3-D TRUS images by measuring the target registration error (TRE). Experimental results showed that the proposed method yielded an overall mean TRE of [Formula: see text] for the rigid registration and [Formula: see text] for the nonrigid registration, which is favorably comparable to a clinical requirement for an error of less than 2.5 mm. A landmark-based nonrigid 3-D MR-TRUS registration approach is proposed, which takes into account the correspondences on the prostate surface, inside the prostate, as well as the centroid of the prostate. Experimental results indicate that the proposed method yields clinically sufficient accuracy.

  14. Incidence of sepsis following transrectal ultrasound guided prostate biopsy at a tertiary-care medical center in Lebanon

    Directory of Open Access Journals (Sweden)

    Mohammed Shahait

    2016-02-01

    Full Text Available ABSTRACT Background Urosepsis is a rare but life-threatening complication following transrectal ultrasound (TRUS guided needle prostate biopsy. Despite the technological and pharmacological improvements, the problem of bacterial urosepsis after prostate biopsy remains. A strategy for preventing urosepsis following TRUS prostate biopsy in areas with high prevalence of resistant strains or patients presenting risk factors is lacking. Objectives The aim of this study was to assess the prevalence of urosepsis, as well its predictors, following TRUS guided needle biopsy of the prostate in a tertiary care medical center in Lebanon. Materials and Methods We carried out a retrospective study on all patients who underwent TRUS prostate biopsy at the American University of Beirut Medical Center between January 1, 2011 and June 31, 2013. Patients’ hospital charts were reviewed. Data collected included demographic information, pre-procedure disease specific information, as well as post-procedure information. Predictors of urosepsis following TRUS were assessed. Results In total, 265 patients were included in this study, where the prevalence of urosepsis following TRUS prostate biopsy was found to be 9.4%. The significant independent predictors of urosepsis were found to be: age with an OR=0.93 (95% CI: 0.88–1.00, p-value=0.03, and hypertension comorbidity with an OR=3.25 (95% CI: 1.19–8.85, p-value=0.02. Conclusion We found a high prevalence of urosepsis among patients who have undergone TRUS prostate biopsy, and identified two significant risk factors. The results of this study highlight the importance of implementing strategies for prevention of urosepsis following TRUS prostate biopsy.

  15. WE-A-17A-11: Implanted Brachytherapy Seed Movement Due to Transrectal Ultrasound Probe-Induced Prostate Deformation

    Energy Technology Data Exchange (ETDEWEB)

    Liu, D; Usmani, N; Sloboda, R [Cross Cancer Institute, Edmonton, Alberta (Canada); University of Alberta, Edmonton, Alberta (Canada); Meyer, T; Husain, S; Angyalfi, S [Tom Baker Cancer Centre, Calgary, Alberta (Canada); University of Calgary, Calgary, Alberta (Canada); Kay, I [Canterbury District Health Board, Christchurch (New Zealand)

    2014-06-15

    Purpose: To characterize the movement of implanted brachytherapy seeds due to transrectal ultrasound probe-induced prostate deformation and to estimate the effects on prostate dosimetry. Methods: Implanted probe-in and probe-removed seed distributions were reconstructed for 10 patients using C-arm fluoroscopy imaging. The prostate was delineated on ultrasound and registered to the fluoroscopy seeds using a visible subset of seeds and residual needle tracks. A linear tensor and shearing model correlated the seed movement with position. The seed movement model was used to infer the underlying prostate deformation and to simulate the prostate contour without probe compression. Changes in prostate and surrogate urethra dosimetry were calculated. Results: Seed movement patterns reflecting elastic decompression, lateral shearing, and rectal bending were observed. Elastic decompression was characterized by anterior-posterior expansion and superior-inferior and lateral contractions. For lateral shearing, anterior movement up to 6 mm was observed for extraprostatic seeds in the lateral peripheral region. The average intra-prostatic seed movement was 1.3 mm, and the residual after linear modeling was 0.6 mm. Prostate D90 increased by 4 Gy on average (8 Gy max) and was correlated with elastic decompression. For selected patients, lateral shearing resulted in differential change in D90 of 7 Gy between anterior and posterior quadrants, and increase in whole prostate D90 of 4 Gy. Urethra D10 increased by 4 Gy. Conclusion: Seed movement upon probe removal was characterized. The proposed model captured the linear correlation between seed movement and position. Whole prostate dose coverage increased slightly, due to the small but systematic seed movement associated with elastic decompression. Lateral shearing movement increased dose coverage in the anterior-lateral region, at the expense of the posterior-lateral region. The effect on whole prostate D90 was smaller due to the subset

  16. Biopsy of the prostate guided by transrectal ultrasound: relation between warfarin use and incidence of bleeding complications

    Energy Technology Data Exchange (ETDEWEB)

    Ihezue, C.U. [Department of Radiology, Southampton General Hospital (United Kingdom); Smart, J. [Department of Radiology, Southampton General Hospital (United Kingdom); Dewbury, K.C. [Department of Radiology, Southampton General Hospital (United Kingdom)]. E-mail: keith.dewbury@suht.swest.nhs.uk; Mehta, R. [Department of Radiology, Southampton General Hospital (United Kingdom); Burgess, L. [Department of Radiology, Southampton General Hospital (United Kingdom)

    2005-04-01

    AIM: To determine the relation between warfarin use and the frequency of bleeding complications after biopsy of the prostate guided by transrectal ultrasound (TRUS). METHODS: Overall, 1022 consecutive patients with suspected prostatic disease were followed after biopsy. Warfarin and aspirin use was determined on the day of the procedure. A TRUS-guided biopsy was performed and patients were offered a questionnaire to complete 10 days after the procedure, to determine any immediate or delayed bleeding complications. Follow-up telephone calls were made to those who had not replied within the stipulated period. RESULTS: Of the 1000 patients who replied, 49 were receiving warfarin, 220 were receiving aspirin and 731 were not receiving any anticoagulant drugs. Of the 49 subjects reporting current use of warfarin, 18 (36.7%) experienced haematuria, compared with 440 (60.2%) of the patients receiving no anti-coagulant drugs who reported haematuria. This was statistically significant (p=0.001). Of the group receiving warfarin, 4 (8.2%) experienced haematospermia whereas 153 (21%) of the group receiving no anticoagulant medication reported haematospermia. This difference also was statistically significant (p=0.030). Rectal bleeding was experienced by 7 (14.3%) of the group receiving warfarin compared with 95 (13%) in the group without anticoagulant medication, but this was not statistically significant (p=0.80). We also demonstrated that there was no statistically significant association between the severity of the bleeding complications and medication with warfarin. CONCLUSION: None of the group receiving warfarin experienced clinically important bleeding complications. Our results suggest that the frequency and severity of bleeding complications were no worse in the warfarin group than in the control group and that discontinuing anticoagulation medication before prostate biopsy may be unnecessary.

  17. Tiroiditis autoinmune inducida por interferón en pacientes con infección por virus de la hepatitis C. Interferon-induced autoimmune thyroiditis in a patient with hepatitis C virus infection

    OpenAIRE

    Pinto, José L.; Miguel E. Pinto

    2011-01-01

    Se reporta el caso de un varón de 43 años de edad, sin antecedentes patológicos de importancia, que acudió por elevación asintomática de la alanino aminotransferasa (ALT). El paciente negó ser bebedor crónico de alcohol. Se hizo el diagnóstico serológico de infección activa por hepatitis C y la biopsia de hígado reveló inflamación crónica activa. Con estos resultados, se inició tratamiento con interferón-alfa y ribavirina. Durante el tratamiento de 48 semanas, el paciente presentó anticuerpos...

  18. Treatment of anastomotic leakage after rectal resection with transrectal vacuum-assisted drainage (VAC). A method for rapid control of pelvic sepsis and healing

    DEFF Research Database (Denmark)

    Nagell, Carl Frederik Otto; Holte, Kathrine

    2006-01-01

    OBJECTIVE: Anastomotic leakage after rectal resection is associated with high morbidity and mortality. Patients without peritonitis can be treated conservatively by transrectal rinsing and drainage. However, healing is often very slow, and formation of abundant scar tissue resulting in a poor...... functional result is not uncommon. Vacuum-assisted closure (VAC) has been shown to accelerate wound healing by increasing local blood flow, reducing bacterial load and stimulating growth of granulation tissue. In this paper, we describe VAC as a method for treating anastomotic leakage after rectal resection...

  19. Application of transrectal ultrasonography in the diagnosis of gynecologic disease%经直肠超声在妇科疾病诊断中的应用

    Institute of Scientific and Technical Information of China (English)

    陶珍; 魏玲玲; 张红安

    2013-01-01

    Objective To discuss the using value of transrectal ultrasonography in the diagnosis of patients with gynecologic disease and nonsexual history. Methods The uterine, ovarian and pelvic of 83 patients were observed by transrectal and abdomen ultrasonography. Results The positive rate of detection results was 78.3%,in which the change of polycystic ovary accounting for 53% of the total cases. Conclusion The detection method and result of transrectal ultrasonography is basically same as transvaginal scan for female patients with nonsexual history;transrectal combined with abdomen ultrasonography can raise the accurately diagnostic rate and provide powerful imaging diagnostic basis for clinical diagnosis through combining with clinical detection results,especially for the diagnosis of polycystic ovarian syndrome.%  目的探讨经直肠超声在无性生活史等患者妇科疾病诊断中的应用价值。方法本组83例患者,采用经直肠超声,结合腹部超声补充检查,观察子宫、卵巢及盆腔情况。结果检出阳性率为78.3%,其中卵巢多囊改变占病例总数的53%。结论对于无性生活史等女性患者,经直肠超声的检查方法及结果,基本等同于经阴道超声检查;把直肠超声和腹部超声结合应用,以提高诊断率,结合临床检验结果,为临床医生的临床诊断,特别是对多囊卵巢综合征的诊断提供了有力的影像诊断依据。

  20. Multi-drug resistant E.coli urosepsis in physicians following transrectal ultrasound guided prostate biopsies--three cases including one death.

    Science.gov (United States)

    Carlson, William H; Bell, David G; Lawen, Joseph G; Rendon, Ricardo A

    2010-04-01

    Three male physicians underwent transrectal ultrasound guided prostate biopsies for elevated prostate-specific antigen levels or irregular digital rectal exam findings. All three of these patients developed urosepsis secondary to multi-drug resistant organisms despite antibiotic prophylaxis. There are increasing reports of infectious complications following prostate biopsy caused by multi-drug resistant organisms. These cases highlight the potentially lethal risks to healthcare workers who are more likely to harbor multi-drug resistant organisms than the general population. Further research into preoperative assessment and appropriate antibiotic prophylaxis in all potentially high risk patients is warranted.

  1. Porocarcinoma ecrino en asociación con tricoepitelioma en una lesión tumoral única, reporte de un caso

    Directory of Open Access Journals (Sweden)

    Pablo Aguilera Huerta

    2010-01-01

    Full Text Available Hombre de 78 años, presenta tumor exofítico en zona frontal de crecimiento acelerado. Se le realiza biopsia que informa una neoplasia maligna de anexo cutáneo, consistente con poroma ecrino maligno. Se extirpa quirúrgicamente la lesión, informándose a la anatomía patológica una lesión correspondiente a un poroma ecrino maligno asociado a zonas de tricoepitelioma. El porocarcinoma es una neoplasia cutánea rara que se origina en la porción ductal intraepidérmica de las glándulas ecrinas. Se presenta en pacientes entre la quinta y octava década de la vida y evoluciona lentamente. Tiene potencial metastásico, puede recidivar e invadir tempranamente los vasos linfáticos dérmicos.

  2. Certeza diagnóstica en la mortalidad de una población de pacientes con trasplante cardíaco

    Directory of Open Access Journals (Sweden)

    Marcos Amuchástegui (h,

    2006-01-01

    Full Text Available Introducción A pesar de que la morbimortalidad en el trasplante cardíaco ha sido motivo de extenso análisis, la mayoría de los estudios y registros de mortalidad en pacientes trasplantados se basan sobre datos clínicos. En la bibliografía existen comunicaciones aisladas de autopsias en pacientes con trasplante cardíaco.Objetivo Determinar la importancia de la realización de estudios anatomopatológicos para el diagnóstico de causa de muerte en un programa de trasplante cardíaco.Material y métodosSe incluyeron todos los pacientes con trasplante cardíaco fallecidos entre enero 1990 y enero 2005. El diagnóstico definitivo de la causa de muerte fue corroborado por autopsia o biopsia de órgano sólido. Las causas de muerte evaluadas fueron falla precoz del injerto, rechazo celular, infección, enfermedad vascular del injerto, neoplasia y otros.ResultadosDurante el período en estudio 73 pacientes fueron sometidos a trasplante cardíaco; de ellos, fallecieron 31. Se obtuvieron 12 autopsias y 7 biopsias de órgano sólido que certificaron la causa de muerte (61%. La causa de muerte más frecuente fue el rechazo celular mayor de grado III. En el 12,9%, la anatomía patológica difirió de la sospecha clínica de la causa de muerte.ConclusiónLa información clinicopatológica derivada de estudios post mortem es un indicador de nuestra realidad asistencial y se constituye en un pilar fundamental para el conocimiento y el manejo futuro de los pacientes trasplantados, por lo que consideramos que la realización de autopsias en estos pacientes es de vital importancia.

  3. Glomus tumor in a patient suffering from Von Recklinghausen disease. A case presentation. Tumor glómico en un paciente con la enfermedad de Von Recklinghausen. Presentación de un caso.

    Directory of Open Access Journals (Sweden)

    Ricardo Souza Bello

    Full Text Available This is a case of a pacient with Von Recklinghausen desease background, she suffers from pain since 2 years evolution in the pulpex of the second finger in the right hand. A physical and radiographic examination is done and a solitary glomal tumor is diagnosed. She goes under surgical treatment with exeresis and biopsia of the lesion. The anatomopathological examination confirmed the glomal tumor diagnosis.

    Se presenta el caso de una paciente con antecedentes de la enfermedad de Von Recklinghausen, que sufre dolor de aproximadamente 2 años de evolución en el pulpejo del segundo dedo mano derecha. Se realiza examen físico y radiográfico y se diagnostica un tumor glómico solitario. Se somete a tratamiento quirúrgico realizándose exéresis y biopsia de la lesión. El examen anatomopatológico confirmó el diagnóstico de tumor glómico.

  4. Prolonged antibiotic therapy increases risk of infection after transrectal prostate biopsy: A case report after pancreasectomy and review of the literature

    Directory of Open Access Journals (Sweden)

    Guevar Maselli

    2014-12-01

    Full Text Available Infection due to prostate biopsy afflicted more than 5% of patients and is the most common reason for hospitalization. A large series from US SEER-Medicare reported that men undergoing biopsy were 2.26 times more likely to be hospitalized for infectious complications within 30 days compared with randomly selected controls. The factors predicting a higher susceptibility to infection remain largely unknown but some authors have higlighted in the etiopathogenesis the importance of the augmented prevalence of ciprofloxacin resistant variant of bacteria in the rectum flora. We present one case of sepsis after transrectal prostate biopsy in a patient with history of pancreatic surgery. Based on our experience patients candidated to prostate biopsy with transrectal technique with history of recent major surgery represent an high risk category for infective complication. Also major pancreatic surgery should be consider an high risk category for infection. A transperineal approach and preventive measures (such as rectal swab should be adopted to reduce biopsy driven infection.

  5. Efficacy and safety of fosfomycin-trometamol in the prophylaxis for transrectal prostate biopsy. Prospective randomized comparison with ciprofloxacin.

    Science.gov (United States)

    Lista, F; Redondo, C; Meilán, E; García-Tello, A; Ramón de Fata, F; Angulo, J C

    2014-01-01

    Prostate biopsy is the standardized diagnostic method for prostate cancer. However, although there is not a standardized protocol, there are recommendations in order to reduce the incidence of complications. The objective of the present work is to assess the efficacy and safety of antibiotic prophylaxis in the prostate biopsy by comparing two antibiotic regimes: two doses of fosfomycin-trometamol 3g (FMT) every 48 hours with 10 doses of oral ciprofloxacin 500 mg every 12 hours during 5 days. Randomized prospective study was performed with 671 patients who had undergone to walking transrectal ultrasound guided prostate biopsy. Patients of group A (n=312) were treated with ciprofloxacin, and patients of group B (n=359) with FMT. Efficacy and tolerability of two prophylactic regimes were compared. Urine culture was carried out at 2 weeks after biopsy. Initially, patients with asymptomatic bacteriuria were not treated with antibiotics; urine culture was repeated after 1 month, persistent bacteriuria was treated according to antibiogram. No differences between groups were found in age (P=.78), cancer presence (P=.9) or number of biopsy cylinders (P=.93). The mean number of cores obtained was 11.3 ± 3.25 (range 6-20). Digestive intolerance was observed for 9 patients (2.9%) of group A and 10 patients (2.8%) in group B. One patient (.3%) of group A showed severe allergic reaction. In total, 167 patients (24.6%) had complications: 16 (2.4%) fever, 47 (6.9%) hemospermia, 81 (11.9%) hematuria, 7 (1%) rectal bleeding and 16 (2.4%) urinary retention. No statistically differences between groups were observed (27.6% vs. 22.6%; P=.17). However, hemospermia was more frequent in group A (9.9% vs. 4.5%; P=.006). Bacteriuria after biopsy was detected in 44 patients (6.6%), being more frequent in group B patients (4.2% vs. 8.6%; P=.02) although a higher number of second treatment cycles were not needed (53.9% vs. 29%; P=.17). The likelihood of resistance to ciprofloxacin in patients

  6. Local anesthesia for pain control during transrectal ultrasound-guided prostate biopsy: a systematic review and meta-analysis

    Directory of Open Access Journals (Sweden)

    Yan P

    2016-10-01

    Full Text Available Pu Yan,* Xiao-yan Wang,* Wei Huang, Yong Zhang Beijing Tian Tan Hospital, Capital Medical University, Neurology Research Division, China National Clinical Research Center for Neurological Disease, Beijing, People’s Republic of China *These authors contributed equally to this work. Background: A meta-analysis was performed to evaluate the efficacy and safety of intrarectal local anesthestic (IRLA, periprostatic nerve block (PPNB, and the combined modalities in alleviating the pain during transrectal ultrasound (TRUS-guided prostate biopsy.Materials and methods: A literature review was performed to identify all published randomized controlled trials (RCTs about IRLA vs no anesthesia or placebo gel; PPNB vs no injection, periprostatic placebo injection, or IRLA; combined PPNB and IRLA vs PPNB alone; and combined PPNB and intraprostatic nerve block (IPNB vs PPNB alone before TRUS-guided biopsy. Sources included MEDILINE, EMBASE, and Cochrane Library from 1980 to 2016. The main outcomes were biopsy pain score, probe manipulation pain score, and anesthetic infiltration pain score assessed by the visual pain scale.Results: A total of 26 articles involving 36 RCTs were used in this analysis: Although IRLA can lead to pain reduction, the result was not statistically significant when compared with no anesthesia or placebo gel (weighted mean difference [WMD]: -0.22, 95% CI: -0.45 to 0, P=0.06. PPNB can lead to significantly lower biopsy pain scores when compared with no analgesia (WMD: -1.32, 95% CI: -1.68 to -0.95, P<0.00001, placebo injection (WMD: -2.62, 95% CI: -3.16 to -2.07, P<0.00001, or IRLA (WMD: -1.31, 95% CI: -1.40 to -1.22, P<0.00001. PPNB + IRLA can lead to significantly lower biopsy pain scores when compared with PPNB alone (WMD: -0.45, 95% CI: -0.62 to -0.28, P<0.00001. PPNB + IPNB can lead to significantly lower biopsy pain scores when compared with PPNB alone (WMD: -0.73, 95% CI: -0.92 to -0.55, P<0.00001. There were no severe

  7. Fluoroquinolone-Resistant Escherichia coli Infections After Transrectal Biopsy of the Prostate in the Veterans Affairs Healthcare System

    Science.gov (United States)

    Saade, Elie A.; Suwantarat, Nuntra; Zabarsky, Trina F.; Wilson, Brigid; Donskey, Curtis J.

    2016-01-01

    Background Recent reports suggest that infections due to fluoroquinolone-resistant Escherichia coli (E. coli) are an increasingly common complication of transrectal biopsy of the prostate (TBP) in the United States. A better understanding of the magnitude and scope of these infections is needed to guide prevention efforts. Our objective is to determine whether the incidence of infections due to fluoroquinolone-resistant E. coli after TBP has increased nationwide in the Veterans Affairs Health Care System and to identify risk factors for infection. Methods We performed a retrospective, observational cohort study and a nested case-control study within the US Deparment of Veterans Affairs Healthcare System. The primary outcomes were the incidence of urinary tract infection (UTI) and bacteremia with E. coli and with fluoroquinolone- resistant E. coli strains within 30 days after TBP. Secondary endpoints focused on the correlation between fluoroquinolone-resistance in all urinary E. coli isolates and post-TBP infection and risk factors for infection due to fluoroquinolone-resistant E. coli infection. Results 245 618 patients undergoing 302 168 TBP procedures from 2000 through 2013 were included in the cohort study, and 59 469 patients undergoing TBP from 2011 through 2013 were included in the nested case-control study. Between 2000 and 2013, there was a 5-fold increase in the incidence of E. coli UTI (0.18%–0.93%) and a 4-fold increase in the incidence of E. coli bacteremia (0.04%–0.18%) after TBP that was attributable to an increase in the incidence of fluoroquinolone- resistant E. coli UTI (0.03%–0.75%) and bacteremia (0.01%–0.14%). The increasing incidence of fluoroquinolone-resistant E. coli infections after TBP occurred in parallel with increasing rates of fluoroquinolone-resistance in all urinary E. coli isolates. By multivariable logistic regression analysis, independent risk factors for fluoroquinolone-resistant E. coli UTI after TBP included diabetes

  8. The criteria for the decision of transrectal US-guided prostate biopsy: Can we reduce the number of unnecessary biopsies?

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Joon Hyung; Cho, Jae Ho; Ahn, Jay Hong; Chang, Jay Chun [Yeungnam University College of Medicine, Taegu (Korea, Republic of)

    2001-09-15

    To establish the criteria which can safely reduce the number of unnecessary biopsies by comparing the transrectal ultrasonography (TRUS) findings, serum prostate-specific antigen (PSA), and prostate specific antigen density (PSAD) in the decision of criteria for the prostatic biopsy using TRUS. Two hundred and twenty patients underwent TRUS- guided prostate biopsy due to elevated PSA and/or focal nodule on TRUS were included. Sixty five (27.5%) patients were confirmed as prostate cancer, and remained 155 (70.5%) patients were reported as benign diseases including benign prostate hyperplasia. The sensitivity, specificity and accuracy of TRUS, PSA and PSAD were evaluated and the single criterion or the combination of the criteria which can safely reduce the unnecessary biopsies without missing prostatic cancer were investigated. The sensitivity, specificity and accuracy of TRUS, PSA (cut-off value, 4 ng/ml) and PSAD (cut-off level, 0.2 ng/ml/cm{sup 3}) were 78.5%/95.4%/95.4%/27.8%/51.6%/64/5%, 42.7%/64.5%/73.6%, respectively. PSAD cut-off level 0.2 ng/ml/cm{sup 3} was the most excellent single criterion for the decision of prostatic biopsy and the number of unnecessary biopsies was 100 cases. But 3 cases of prostatic cancer which the PSAD level was below 0.2 ng/ml/cm{sup 3} were included and in all these 3 cases, a focal nodule was detected on TRUS. Therefore, we applied these two criteria at once and the biopsies of 30 cases (13.6%) are unnecessary. With the single criterion, we could not obtain the satisfactory results but by the combinations of criteria (TRUS and PSAD), 30 (13.6%) cases are unnecessary biopsies without missing cancer. We think that the short term follow-up may be a substitute for the immediate when nodular lesion is suspicious on TRUS and serum PSAD level is below 0.2 ng/ml/cm{sup 3}.

  9. Infection after transrectal ultrasonography-guided prostate biopsy: increased relative risks after recent international travel or antibiotic use.

    Science.gov (United States)

    Patel, Uday; Dasgupta, Prokar; Amoroso, Peter; Challacombe, Ben; Pilcher, James; Kirby, Roger

    2012-06-01

    Study Type - Prognosis (case series) Level of Evidence 4 What's known on the subject? and What does the study add? Septicaemia is the most frequent cause of hospitalization after transtrectal prostate biopsy; fatalities have been reported and the incidence is on the rise. This study shows that men with a history of recent international travel or antibiotic use have up to four times increased risk of septicaemia and hospitalization. When they do occur, infections are usually due to multi-resistant E coli and additional care, e.g. delay before biopsy, different antibiotic prophylaxis or transperineal biopsy, should be considered in these cases. OBJECTIVE • To study the infection rate after prostate biopsy in those who have travelled overseas or used antibiotics in the 4 weeks before biopsy. PATIENTS AND METHODS • A total of 316 men with a mean (range) age of 61 (45-85) years were studied. All had undergone transrectal ultrasonography (TRUS)-guided prostate biopsy after standard antibiotic prophylaxis. • Before their biopsy the patients were risk stratified and a history of recent international travel or antibiotic use was recorded. • Those who suffered sufficiently severe infection/sepsis so as to require hospitalization were identified at the end of the study period. • The characteristics of these patients and the types of infections were explored and the relative risk (RR) of infection after recent travel or antibiotic use was calculated. RESULTS • Of the 316 men, 16 were hospitalized with infection. • The group with (n= 16) and without (n= 300) infection were equivalent in age, prostate-specific antigen level, disease status and number of biopsy cores taken. • Either recent travel or antibiotic use were independent risk factors for infection [travel: 8/16 vs 76/300; P= 0.04; RR 2.7 and antibiotic use: 4/16 vs 20/300; P= 0.025; RR 4]. There was no significant pattern in the countries visited or the type of antibiotic used. • Culture results were

  10. Educar con significado o con sentido

    Directory of Open Access Journals (Sweden)

    José Joaquín García García

    2017-01-01

    Full Text Available Hoy día, tres tendencias influyen directamente en la conformación de la escuela. En primer lugar, el afán de encontrar la esencia de todo encumbró a la razón e hizo de la racionalidad el único valor a defender en las aulas. En segundo lugar, el sistema capitalista hizo lo mismo con aquello que tiene valor de uso y valor de cambio, es decir, con la mercancía, validando solo lo que puede tener una utilidad económica conocida o posible. Esto convirtió a la educación en un proceso para certificar y ganar dinero, desdibujando así su intención de formar personas. Finalmente, la visión masculina y eurocéntrica con su locura por quererlo dominar todo, y de pensar que el hombre era el dueño del planeta e inclusive la vida y el destino de los otros hombres, mutiló culturas y eliminó a la naturaleza de los currículums en los centros educativos.

  11. con turbinas de disco con paletas planas

    Directory of Open Access Journals (Sweden)

    D. García-Cortés

    2006-01-01

    Full Text Available Las turbinas de disco con paletas planas son los impelentes de flujo radial más ampliamente utilizados en la industria por constituir el impelente que forma parte de la configuración geométrica estándar para obtener este patrón de flujo en los tanques agitados. El estudio detallado de la hidrodinámica en este sistema de agitación es fundamental para continuar obteniendo conocimientos básicos imprescindibles para la síntesis y la modelación matemática de diferentes procesos complejos que se llevan a cabo en los tanques agitados, por ejemplo, la cristalización esférica. El propósito de este artículo es hacer una revisión de la información publicada sobre la hidrodinámica y la modelación matemática de la dinámica de fluidos en los tanques agitados con turbinas de disco con paletas planas y señalar los avances logrados en cada uno de los aspectos abordados y aquellos en los cuales es necesario seguir investigando.

  12. Investigando con personas con dificultades de aprendizaje

    Directory of Open Access Journals (Sweden)

    Borja González Luna

    2013-12-01

    Full Text Available El artículo muestra los orígenes de lo que Walmsley (2008 denomina «investigación inclusiva». Para comprender qué se entiende por investigación inclusiva tenemos que remontarnos a los debates epistemológicos sobre las metodologías cuantitativas y cualitativas, acontecidos en la década de los 90, en torno a la revista Disability & Society. A partir de una síntesis de dichos debates, focalizados en el ámbito de la «discapacidad intelectual y del desarrollo», se exponen dos estrategias de colaboración con dicha población: a una aproximación etnográfica (de trabajo grupal, y b una aproximación biográfica (de trabajo individual. A continuación se esboza un posible diseño de trabajo de campo que intenta superar el paradigma cualitativo «clásico» con el objetivo de incluir a dicho colectivo más allá del rol de «sujetos de la investigación». Para finalizar se recoge el debate sobre la accesibilidad de los resultados de la investigación a los participantes en dichas investigaciones, y con ello la necesaria innovación en el ámbito de las «devoluciones» de los resultados, cuando se trata de incluir a personas que presentan limitaciones para la comprensión del lenguaje abstracto oral y/o escrito.

  13. Recidiva en bronquiolitis obliterante con neumonía en organización: BOOP RELAPSE IN BRONCHOLITIS OBLITERANS ORGANIZING PNEUMONIA: BOOP

    Directory of Open Access Journals (Sweden)

    JUAN I. VARGAS RT.

    2003-01-01

    Full Text Available Las recaídas son frecuentes en la bronquiolitis obliterante con neumonía en organización (BOOP, sin embargo, existe poca información con respecto a su causa. Se presenta el caso de una mujer de 63 años con un cuadro clínico radiológico compatible con BOOP. No se identificó una causa subyacente por lo que se planteó el diagnóstico de neumonía en organización criptogénica o COP. Se realizaron biopsias transbronquiales que demostraron una neumonía crónica organizada y bronquiolitis proliferativa. Se trató con prednisona con buena respuesta. Al octavo mes de tratamiento, mientras se disminuía la dosis de esteroides, comenzó con disnea y tos y aparición de nuevas opacidades pulmonares radiológicos, las que regresaron rápidamente al aumentar la dosis de esteroides. Discutimos las causas posibles de la recidiva de esta patología y su relación con la disminución de la dosis de esteroidesAlthough relapses are frequent in bronchiolitis obliterans organizing pneumonia (BOOP, there is scant information regarding the causes underlying its occurrence. We report a 63 year old woman with clinical and radiological features compatible with BOOP. No underlying cause was identified so she was thought to have cryptogenic BOOP or cryptogenic organizing pneumonia (COP. A transbronchial lung biopsy demonstrated chronic organizing pneumonia and features of proliferative bronchiolitis. She was successfully treated with prednisone. On the eighth month of steroid therapy, while tapering the dose, she begun with cough and dyspnea and developed new lung infiltrates on the chest x-ray film. The infiltrates cleared rapidly after increasing the dose of steroids. We discuss the possible causes of relapse in BOOP and its relation to steroid therapy

  14. Sarcoidosis: experiencia con 15 casos en el Hospital Calderón Guardia

    Directory of Open Access Journals (Sweden)

    José Mainieri-Hidalgo

    2002-06-01

    Full Text Available La sarcoidosis es una enfermedad que se diagnostica con poca frecuencia en Costa Rica; en 1988 fueron informados 6 casos en el Hospital San Juan de Dios. En este estudio se da cuenta de las características clínicas y el manejo de 15 pacientes del Hospital Calderón Guardia, diagnosticados entre 1987 y 2001. Todos los casos fueron de localización torácica y en doce de ellos la enfermedad afectó solamente los ganglios del mediastino, por lo que la radiografía de tórax fue el método de detección . Los síntomas más frecuentes fueron tos y disnea. La mediastinoscopía fue el método más utilizado para obtener la biopsia. El diagnóstico histológico se hizo por el hallazgo de granulomas no necrotizantes, infiltrado linfocitario y la presencia de células gigantes, sin que se aislara ningún germen. Catorce pacientes recibieron tratamiento sintomático y observación y solo uno presentó afección pulmonar y sintomatología respiratoria y recibió esteroides. El paciente con enfermedad pulmonar sintomática continúa con esteroides y los pacientes observados, por un promedio de 7 años, evolucionaron a resolución espontánea sin producirse recidivas.

  15. Morbidade da biópsia da próstata transretal guiada por ultrassonografia Morbidity of transrectal ultrasound guided prostate biopsy

    Directory of Open Access Journals (Sweden)

    Raphael Sandes Solha

    2013-04-01

    Full Text Available OBJETIVO: Avaliar a incidência de complicações pós-procedimento nos pacientes submetidos a biópsia prostática transretal guiada por ultrassom no setor de intervenção do Departamento de Diagnóstico por Imagem da Escola Paulista de Medicina - Universidade Federal de São Paulo. MATERIAIS E MÉTODOS: Foram avaliados, via contato telefônico, 132 pacientes submetidos a biópsia de próstata transretal guiada por ultrassom no período de abril/2011 a junho/2011, seguindo o protocolo padrão do nosso setor. RESULTADOS: As complicações pós-biópsia foram categorizadas em maiores e menores de acordo com a necessidade de avaliação médica adicional. Cinquenta e nove pacientes (61,8% apresentaram complicações, e desses, grande parte (86,4% apresentou sintomas leves e autolimitados, considerados menores. Oito pacientes (8,2% apresentaram complicações maiores, sendo que apenas um deles necessitou de tratamento sob regime de internação hospitalar. A retenção urinária foi a complicação maior mais incidente no nosso estudo. CONCLUSÃO: Corroborando outros estudos da literatura, nosso trabalho demonstrou baixa prevalência de complicações maiores após a biópsia prostática transretal.OBJECTIVE: To evaluate the incidence of postprocedural complications in patients submitted to transrectal ultrasound-guided prostate biopsy at the Unit of Intervention, Department of Imaging Diagnosis of Escola Paulista de Medicina - Universidade Federal de São Paulo. MATERIALS AND METHODS: Telephone interviews were conducted with 132 patients who had undergone transrectal ultrasound-guided prostate biopsy in the period from April 2011 to June 2011, according to the institution's protocol. RESULTS: Post-biopsy complications were categorized into two groups - minor and major complications, according to their need for further clinical evaluation. Complications were reported by 59 patients (61.8%, most of them (86.4% with mild and self-limited symptoms

  16. Toward a 3D transrectal ultrasound system for verification of needle placement during high-dose-rate interstitial gynecologic brachytherapy.

    Science.gov (United States)

    Rodgers, Jessica Robin; Surry, Kathleen; Leung, Eric; D'Souza, David; Fenster, Aaron

    2017-05-01

    Treatment for gynecologic cancers, such as cervical, recurrent endometrial, and vaginal malignancies, commonly includes external-beam radiation and brachytherapy. In high-dose-rate (HDR) interstitial gynecologic brachytherapy, radiation treatment is delivered via hollow needles that are typically inserted through a template on the perineum with a cylinder placed in the vagina for stability. Despite the need for precise needle placement to minimize complications and provide optimal treatment, there is no standard intra-operative image-guidance for this procedure. While some image-guidance techniques have been proposed, including magnetic resonance (MR) imaging, X-ray computed tomography (CT), and two-dimensional (2D) transrectal ultrasound (TRUS), these techniques have not been widely adopted. In order to provide intra-operative needle visualization and localization during interstitial brachytherapy, we have developed a three-dimensional (3D) TRUS system. This study describes the 3D TRUS system and reports on the system validation and results from a proof-of-concept patient study. To obtain a 3D TRUS image, the system rotates a conventional 2D endocavity transducer through 170 degrees in 12 s, reconstructing the 2D frames into a 3D image in real-time. The geometry of the reconstruction was validated using two geometric phantoms to ensure the accuracy of the linear measurements in each of the image coordinate directions and the volumetric accuracy of the system. An agar phantom including vaginal and rectal canals, as well as a model uterus and tumor, was designed and used to test the visualization and localization of the interstitial needles under idealized conditions by comparing the needles' positions between the 3D TRUS scan and a registered MR image. Five patients undergoing HDR interstitial gynecologic brachytherapy were imaged using the 3D TRUS system following the insertion of all needles. This image was manually, rigidly registered to the clinical

  17. Treatment of anastomotic leakage after rectal resection with transrectal vacuum-assisted drainage (VAC). A method for rapid control of pelvic sepsis and healing

    DEFF Research Database (Denmark)

    Nagell, Carl Frederik Otto; Holte, Kathrine

    2006-01-01

    functional result is not uncommon. Vacuum-assisted closure (VAC) has been shown to accelerate wound healing by increasing local blood flow, reducing bacterial load and stimulating growth of granulation tissue. In this paper, we describe VAC as a method for treating anastomotic leakage after rectal resection......OBJECTIVE: Anastomotic leakage after rectal resection is associated with high morbidity and mortality. Patients without peritonitis can be treated conservatively by transrectal rinsing and drainage. However, healing is often very slow, and formation of abundant scar tissue resulting in a poor....... METHODS: Four patients with anastomotic leakage after rectal resections were treated with VAC. RESULTS: Healing time for these patients was median 51 days (43-195). The control group consisted of patients treated conservatively in the previous 5-year period. Ten patients were identified with median...

  18. [Case of septic shock caused by extended spectrum β-lactamase producing Escherichia coli after transrectal prostate biopsy, successfully treated by endotoxin adsorption therapy].

    Science.gov (United States)

    Kohno, Yusuke; Fukui, Naotaka; Kageyama, Yukio; Higashi, Yotsuo

    2013-09-01

    A 62-year-old man, with a family history of prostate cancer, referred to our hospital because of elevated prostate-specific antigen (PSA) (6.02 ng/ml). After prophylactic administration of antibiotics (cefotiam), transrectal needle biopsy of the prostate was performed. He was admitted to the hospital due to high fever the next evening. His blood pressure was below the shock level, and his renal function deteriorated progressively. Suspecting septic shock, the patient was treated with Meropenem, γ-globulin, and dopamine, which were not effective. Then, endotoxin adsorption therapy was employed and the condition of the patient recovered soon after the initiation of the therapy. Extended spectrum β -lactamase-producing Escherichia coli was found in his urine. Pathological diagnosis of the biopsy specimen was atypical glands.

  19. Assessment of Prospectively Assigned Likert Scores for Targeted Magnetic Resonance Imaging-Transrectal Ultrasound Fusion Biopsies in Patients with Suspected Prostate Cancer.

    Science.gov (United States)

    Costa, Daniel N; Lotan, Yair; Rofsky, Neil M; Roehrborn, Claus; Liu, Alexander; Hornberger, Brad; Xi, Yin; Francis, Franto; Pedrosa, Ivan

    2016-01-01

    We assess the performance of prospectively assigned magnetic resonance imaging based Likert scale scores for the detection of clinically significant prostate cancer, and analyze the pre-biopsy imaging variables associated with increased cancer detection using targeted magnetic resonance imaging-transrectal ultrasound fusion biopsy. In this retrospective review of prospectively generated data including men with abnormal multiparametric prostate magnetic resonance imaging (at least 1 Likert score 3 or greater lesion) who underwent subsequent targeted magnetic resonance imaging-transrectal ultrasound fusion biopsy, we determined the association between different imaging variables (Likert score, lesion size, lesion location, prostate volume, radiologist experience) and targeted biopsy positivity rate. We also compared the detection of clinically significant cancer according to Likert scale scores. Tumors with high volume (50% or more of any core) Gleason score 3+4 or any tumor with greater Gleason score were considered clinically significant. Each lesion served as the elementary unit for analysis. We used logistic regression for univariate and multivariate (stepwise selection) analysis to assess for an association between targeted biopsy positivity rate and each tested variable. The relationship between Likert scale and Gleason score was evaluated using the Spearman correlation coefficient. A total of 161 men with 244 lesions met the study eligibility criteria. Targeted biopsies diagnosed cancer in 41% (66 of 161) of the men and 41% (99 of 244) of the lesions. The Likert score was the strongest predictor of targeted biopsy positivity (OR 3.7, p Likert score, lesion size and prostate volume were significant predictors of targeted biopsy positivity. Higher Likert scores were also associated with increased detection of clinically significant tumors (p Likert scale score used to convey the degree of suspicion on multiparametric magnetic resonance imaging is the strongest

  20. en pacientes con obesidad

    Directory of Open Access Journals (Sweden)

    Alcia María Alvarado Sánchez

    2005-01-01

    Full Text Available El objetivo de este estudio fue evaluar la eficacia de una intervención psicológica en pacientes con obesidad. Se utilizó un diseño cuasiexperimental con un grupo de estudio y un grupo control. Después de la intervención, se encontró una diferencia significativa en la reducción de peso entre los grupos. Asimismo, hubo un incremento significativo en la autoestima del grupo estudiado.

  1. Soledad con espectador

    OpenAIRE

    2011-01-01

    Este proyecto se plantea como una investigación de las posibilidades del dibujo como una herramienta para relatar una historia propia que se empapa de realidad y de ficción con el deseo de confundir al espectador y suscitarle preguntas. Para ello me he servido de mi propia imagen como personaje central. Éste se presenta duplicado, multiplicado, repetido e interactúa consigo mismo en un espacio imaginario con intención de simular aquello que se revela en el interior de la psique. Mi trabajo se...

  2. Funcionando con la computadora

    OpenAIRE

    Álvarez, Eduardo; Astiz, Mercedes; Medina, Perla; Montero, Y.; Oliver, María; Rocerau, M. Cristina; VALDEZ, Guillermo; Vecino, María; Vilanova, Silvia

    2004-01-01

    En este trabajo se presenta la descripción y resultados de la segunda etapa de una experiencia planteada con el objetivo de indagar la manera en que los alumnos determinan e interpretan funciones que explican situaciones problemáticas valiéndose de una nueva forma de trabajo en el aula: la utilización de la computadora como herramienta y un programa asistente matemático. La primera etapa consistió en el desarrollo de un taller optativo con alumnos de entre 14 y 15 años de edad del Colegio Dr....

  3. Giochiamo con i robot

    Directory of Open Access Journals (Sweden)

    Andrea Bonarini

    2009-01-01

    Full Text Available "Giochiamo con i robot" e' un laboratorio interattivo per grandi e piccini realizzato per l'edizione 2007 del Festival della Scienza di Genova. Lungo un percorso che va dalla telerobotica alla robotica evolutiva, il laboratorio sviluppa il tema di dare intelligenza ai robot. Questo percorso, le cui tappe sono le varie installazioni, si conclude nella "bottega" dove e' possibile costruire e programmare i propri robot o smontare e modificare quelli esposti durante il percorso didattico. I visitatori sono coinvolti in attivita' ludiche grazie alle quali possonoentrare in contatto con alcune delle idee potenti della robotica,

  4. Relación de la susceptibilidad genética y de las características anatomopatológicas del cáncer de próstata con los polimorfismos de nucleótido simple

    OpenAIRE

    2012-01-01

    Actualmente no se disponen de marcadores biológicos específicos para la cáncer de próstata produciéndose en muchas ocasiones biopsias prostáticas innecesarias o un sobretratamientos para cánceres indolentes. Existen cada vez más un número mayor de publicaciones sobre cómo los polimorfismos de nucleótido simple (SNP) se relacionan con la susceptibilidad al cáncer de próstata o predecir con mayor precisión qué grado de agresividad adquiere la enfermedad. Se presenta una revisión bibliográfica d...

  5. VASCULITIS DE CHURG-STRAUSS: PRESENTACIÓN CLÍNICA COMO GLOMERULONEFRITIS EXTRACAPILAR NECROTIZANTE PAUCI-INMUNE CON NEFRITIS TUBULO-INTERSTICIAL EOSINOFÍLICA.

    Directory of Open Access Journals (Sweden)

    Fernanda da Cunha

    2004-01-01

    Full Text Available RESUMEN: Se presenta el caso clínico de una mujer de 81 años con antecedentes patología pulmonar obstructiva crónica "idiopática" que desarrolló un cuadro de insuficiencia renal aguda aparentemente prerrenal, con posterior oliguria y eosinofilia simulando una nefropatía túbulo-intersticial alérgica. La evolución atípica y la presencia de p-ANCA, sugerían una vasculitis, patología que se confirmó con la biopsia renal. Los resultados anatomopatológicos revelaron la existencia de una glomerulonefritis necrotizante con semilunas e infiltrado eosinófilo. Estos datos y el historial de la paciente llevaron al diagnóstico de vasculitis de Churg-Strauss. El tratamiento inicial con corticoides y ciclofosfamida y posteriormente con Azatioprina mostró excelentes resultados con mejoría de la función renal, de los parámetros inflamatorios y de la clínica sistémica, que la paciente mantuvo posteriormente. ABSTRACT: We report a case of a 81 year-old woman with idiopathic chronic obstructive pulmonary disease, who developed a functional acute renal failure with delayed oliguria and eosinophily, simulating an acute interstitial nephropathy. The unusual clinical course and the presence of antimyeloperoxidase antibodies (p-ANCA suggested a vasculitis; the renal biopsy confirmed this diagnosis. The histology revealed a crescentic glomerulonephritis with eosinophilic infiltration. With these data and the pulmonary history of the patient, a diagnosis of Churg-Struss Vasculitis was made. The initial treatment with steroids and ciclophosphamide switched later to azatioprine, was succeeded with a sustained improvement in renal function, inflammatory markers and clinical course.

  6. Breast cancer only detected at US. Incidental finding or clinical evidence?; Le neoplasie mammarie visualizzabili solo con esame ecografico. Reperti incidentali o realta' clinica?

    Energy Technology Data Exchange (ETDEWEB)

    Nori, J.; Masi, A.; Boeri, C.; Vivian, A.; Nori Bufalini, F. [Azienda Ospedaliera Careggi, Florence (Italy). Unita' Operativa di Radiodiagnostica 2; Cariti, G. [Florence Univ., Florence (Italy). Dipt. di Ginecologia e Ostetricia

    2000-06-01

    orientativi per patologia neoplastica della mammella hanno eseguito esame clinico, mammografia, ecografia mammaria, prelievo microistologico ecoguidato e intervento operatorio. Quattordici neoplasie mammarie, con dimensioni comprese tra 7 e 15 mm sono state evidenziate solo ecograficamente. La mammografia eseguita nelle 2 o 3 incidenze abituali, e' risultata sempre negativa. Le lesioni neoplastiche evidenziate solamente con l'esame ecografico (10% di tutti i carcinomi) sono state caratterizzate con biopsia istologica con ago da 14G e definitivamente confermate con intervento chirurgico. I risultati ottenuti permettono di suggerire che l'esame ecografico debba essere metodica da includere nell'iter diagnostico nelle donne con mammelle scarsamente leggibili. Le lesioni nodulari ipoecogene sospette rilevate all'esame ecografico in una donna con visita e mammografia negative meritano di essere ulteriormente approfondite (controllo con ecografia, agoaspirazione per citologia o biopsia istologica con ago) al fine di ottenere la definitiva caratterizzazione.

  7. EMBOLIA GASEOSA CEREBRAL SECUNDARIA A BIOPSIA PULMONAR

    Directory of Open Access Journals (Sweden)

    Luís Rafael Moscote Salazar

    2008-01-01

    Full Text Available A 68-year-old male patient, underwent a lung biopsy. During the procedure, the patient had sudden loss of consciousness. A simple brain computed tomography was performed. Brain images showed multiple hypodenses areas in the brain parenchyma and subarachnoid space, making the diagnosis of cerebral gaseous embolism.Our case demonstrates the importance of considering the gaseous cerebral embolism when presented sudden loss of consciousness during invasive procedures such as lung biopsy or introduction of arterial and venous catheters.

  8. Características clínicas, bioquímicas y epidemiológicas de un grupo de pacientes con diagnóstico imaginológico de hígado graso

    Directory of Open Access Journals (Sweden)

    Juan Carlos Restrepo

    2001-04-01

    Full Text Available En nuestro medio, la esteatosis o infiltración hepática grasa se
    convierte casi siempre en un hallazgo imaginológico incidental, al cual
    se la da muy poca importancia desde el punto de vista clínico, y por
    ende no se realizan estudios posteriores para determinar su causa, las condiciones asociadas que lo expliquen (1, y mucho menos se realiza biopsia hepática para determinar, cuáles de estos pacientes tienen esteatohepatitis, algún grado de fibrosis o incluso cirrosis. Este trabajo tuvo como objetivo describir las características epidemiológicas, clínicas y bioquímicas de un grupo de pacientes con diagnóstico imaginológico de hígado graso.

  9. O papel da biopsia pulmonar na indicação cirúrgica de cardiopatias congénitas The role of lung biopsy in the decision-making process for congenital heart disease

    Directory of Open Access Journals (Sweden)

    Solange Bordignon

    1992-12-01

    Full Text Available Objetivando relacionar o aspecto morfológico dos vasos pulmonares com os dados clínicos para auxiliar na decisão da cirurgia de cardiopatias congênitas com hipertensão pulmonar severa, em casos previamente avaliados por critérios clínicos, angiográficos e/ou hemodinâmicos, foram realizadas, de 1980 a 1991, no Instituto de Cardiologia do Rio Grande do Sul, 49 biópsias pulmonares. As idades dos pacientes variaram de 5m a 28a6m (média = 7a7m e os diagnósticos foram: CIV (16, PCA (3, CIVe ESubAo (1, PCA e CIV (2, PCA e Cl A (1 DSAV (7, DSAV incompl. e PCA (1, PCA e CoAo (1, Inter Arco Ao com PCA e CIV e/ou ESupraM e Anel SubAo (2, DVSVD com CIV e/ou PCA (6, DVSVE e EP (1, ATe ESubP. (1, TGV (1, TGV corrigida e CIV (1 e truncus arteriosus (5. Houve 3 (6,1 % óbitos no pós-operatório da biopsia. Baseado na classificação de Heath-Edwards, foram para correção cirúrgica 11 pacientes com cardiopatias simples (CIV, PCA, DSAV, cuja mortalidade foi 36,4%. Dez pacientes com cardiopatias complexas (DVSVD, DVSVE, TGV, truncus, inter arco Ao foram para cirurgia, com mortalidade de 30%. A evolução pós-operatória tardia foi favorável em 13 (62% pacientes. Conclui-se que a biopsia pulmonar pode ser útil na indicação cirúrgica das cardiopatias congênitas com hipertensão pulmonar severa e, por envolver riscos, sua utilização deve ser criteriosa. E valiosa para os pacientes que apresentam dúvidas quanto ao grau de doença vascular pulmonar ou quanto à natureza das lesões e o estudo clínico e hemodinâmico não são esclarecedores, ou mesmo quando apontarem para a contra-indicação cirúrgica.Open lung biopsy has been performed in patients with congenital heart disease and severe pulmonary hypertension in order to complement the decision-making process for surgical correction. All patients had clinical, hemodynamic and angiographic evaluation previously and would not be surgical candidates by conventional criteria. The 49 patients

  10. Correlations between contrast enhanced color Doppler US and neoangiogenesis in small prostate carcinomas; Correlazioni tra color Doppler con uso di mezzo di contrasto e neoangiogenesi dei piccoli carcinomi prostatici

    Energy Technology Data Exchange (ETDEWEB)

    Lagalla, R.; Caruso, G.; Caruso, R.; Bizzini, G. [Policlinico Universitario P. Giaccone, Palermo (Italy). Ist. di Radiologia; Marasa' , L. [Ospedale Oncologico M. Ascoli, Palermo (Italy). Servizio di Anatomia Patologica; Miceli, V. [Policlinico Universitario P. Giaccone, Palermo (Italy). Ist. di Clinica Urologica

    2000-04-01

    Aim of the work was to investigate if the use of a contrast agent (Levovist) improves the specificity of ultrasonography in the diagnosis of prostate carcinoma, having the results of prostate biopsy as the gold standard. The results have been compared with the microscopic angiogenesis grading system (MAGS) index; they exceed 30 in 11 avascular lesions value indicates microangiogenesis. In the other two cases a minor value of 30 was correlated with a different type of tumor vascularisation typical of macroangiogenesis. [Italian] Scopo del lavoro e' verificare se l'impiego del mezzo di contrasto Levovist (Schering, Berlino) consente di migliorare la specificta' dell'esame ecografico nella diagnosi del carcinoma prostatico, avendo come riferimento i risultati della biopsia prostatica. Trenta pazienti con esame obiettivo sospetto per carcinoma prostatico e antigene prostatico specifico (PSA) compreso tra 5 e 15 ng/ml, sono stati studiati con ecografia transrettale integrata da esame color Doppler e somministrazione di mdc. I risultati ottenuti sono stati confrontati con l'indice Microscopic Angiogenesis Grading System (MAGS) che nelle sezioni istologiche degli 11 casi con aspetto avascolare e' stato superato a 30, espressione di microgenesi; negli altri due casi, il valore inferiore a 30 e' conciso con un differente modello di vascolarizzazione neoplastica proprio della microangiogenesi.

  11. fertilizada con diferentes abonos

    Directory of Open Access Journals (Sweden)

    Jorge Alberto Elizondo-Salazar

    2007-01-01

    Full Text Available Producción y calidad de la biomasa de morera (Morus alba fertilizada con diferentes abonos. Se llevó a cabo un experimento en la Estación Experimental “Alfredo Volio Mata” de la Universidad de Costa Rica con el fi n de evaluar la aplicación de 150 kg de N/ha/año proveniente de dos abonos orgánicos: lombriabono y compostaje; y de un fertilizante químico, sobre la producción y calidad de la biomasa de morera. El periodo experimental comprendió un ciclo de 12 meses, iniciando en julio del 2003 y fi nalizando en julio del 2004. Se utilizó una plantación de morera de 12 años de establecida con una densidad de siembra de 27.777 plantas/ ha. Se empleó un diseño de bloques completos al azar con cuatro tratamientos: dos abonos orgánicos, nitrato de amonio (33,5% N y un control. Las plantas se podaron a 0,6 m sobre el nivel del suelo al inicio del ensayo. Durante el periodo experimental, las plantas fueron podadas consecutivamente cada 90 días. Las hojas y los tallos fueron separados y analizados para determinar el contenido de materia seca y proteína cruda. La producción de materia seca fue 23% superior y el contenido de proteína cruda fue signifi cativamente mayor con el nitrógeno químico, mientras que el contenido de materia seca fue menor. No se encontraron diferencias signifi cativas entre el tratamiento control y los tratamientos orgánicos.

  12. Mucormicosis yeyunal en paciente con linfoma de Hodgkin Jejunal mucormycosis in a patient with Hodgkin's lymphoma

    Directory of Open Access Journals (Sweden)

    B. Madrigal

    2008-08-01

    Full Text Available Comunicamos un caso de mucormicosis intestinal en un hombre de 46 años de edad, diagnosticado de enfermedad de Hodgkin clásica, estadio IV-B. Durante la primera fase de la quimioterapia, sufrió una hemorragia digestiva masiva secundaria a una úlcera yeyunal por zigomicosis tipo mucor, diagnosticada por biopsia endoscópica. El paciente fue tratado con antifúngicos y resección quirúrgica del intestino afectado. En la cirugía, se apreció una doble perforación yeyunal cubierta. El estudio anatomopatológico de la pieza confirmó el diagnóstico previo. Tras un año de seguimiento, el paciente está recuperado y su linfoma de Hodgkin en remisión completa. Tras una extensa revisión de la literatura, según nuestro conocimiento, este es el segundo caso publicado en la literatura de mucormicosis intestinal en un paciente con linfoma de Hodgkin.We report a case of intestinal mucormycosis in a 46-year-old male diagnosed with classical Hodgkin's disease, IV-B stage. During the first phase of chemotherapy he had a massive digestive bleeding event secondary to a jejunal ulcer, and zygomicosis mucor-type was diagnosed by endoscopic biopsy. The patient was treated with antifungal drugs and surgical resection of the intestine involved. At surgery a double covered perforation of the jejunum was seen. Pathological examination confirmed the previous diagnosis. After one year of follow-up the patient is doing well, and his lymphoma is on remission. To our best knowledge this is the second case of intestinal mucormycosis in a patient with Hodgkin's lymphoma reported in the medical literature.

  13. TRANSRECTAL ULTRASOUND TO IDENTIFY THE SEX OF CAPRINE FETUSES ULTRASSONOGRAFIA TRANSRETAL PARA IDENTIFICAR O SEXO FETAL DE CAPRINOS

    Directory of Open Access Journals (Sweden)

    Cristiano Rocha Aguiar Filho

    2010-04-01

    Full Text Available The aim of this study was to establish the period for sexing caprine fetuses by transrectal ultrasonography through viewing the structures of the external genitalia, monitoring of the final positioning of the genital tubercle, and the day that the penis, scrotum, clitoris and nipples were seen. Fetuses of Boer (n = 36, Brownscale Alpine (n = 31 and Anglo-nubian (n = 27, breeds in the 40th-60th day of gestation, were tracked using linear transducer of 6.0 and 8.0 MHz. The final positioning of the genital tubercle occurred in the period from 47.11 ± 1.45 days in males and 45.62 ± 1.36 days in females. The visualization of structures of the external genitalia was in the period from 49.42 ± 2.20 days for scrotum; 49.37 ± 2.19 days for penis; 49.23 ± 1.75 days for nipples and 49.98 ± 2.52 days for clitoris. The migration of female genital tubercle in the fetus occurred earlier (P < 0.05 than in males, and the visualization of penis and scrotum was earlier (P < 0.05 than the nipples and clitoris, there was no difference (P > 0.05 among the structures of the same sex. In conclusion, although the sexing of caprine fetuses can be done before the 55th day of pregnancy, it is recommended to perform it only after the visualization of the structures of the external genitalia for a greater security in the sex identification.

    KEY WORDS: Clitoris. nipples, penis, scrotum, sexing.

    Procurou-se estabelecer o período para sexar fetos caprinos pela ultrassonografia transretal visibilizando-se as estruturas da genitália externa, sendo que para tal foi monitorado o dia do posicionamento final do tubérculo genital (TG, bem como o dia em que o pênis, a bolsa escrotal, o clitóris e as tetas foram visibilizados. Foram monitorados fetos das raças Boer (n = 36, Parda Alpina (n = 31 e Anglo-nubiana (n = 27, do 40o ao 60o dia de gestação, usando-se transdutor linear de 6,0 e 8,0 MHz. O posicionamento final do TG ocorreu no período de 47

  14. sistema Web con JSP

    Directory of Open Access Journals (Sweden)

    César Viloria Núñez

    2014-01-01

    Full Text Available Este artículo presenta el desarrollo de un sistema de información que permite la adquisición y la administración de información relacionada con los signos vitales como la presión arterial, la frecuencia cardiaca y respiratoria, y la saturación de oxígeno en la sangre de un paciente. La implementación del sistema se basa en una solución Web, permitiendo así que médicos especialistas puedan monitorear a sus pacientes desde cualquier punto conectado a la red en tiempo real y, al mismo tiempo, dar indicaciones críticas al personal médico que se encuentra en el lugar con el paciente.

  15. Inflamación granulomatosa crónica: métodos de detección de bacilos ácido alcohol resistentes en biopsias embebidas en parafina

    OpenAIRE

    Bustamante Rengifo Javier Andres; Bravo Ocaña Luis Eduardo; Pazos Mocayo Alvaro Jairo; Astudillo Hernadez Miryam

    2010-01-01

    La detección de bacilos ácido alcohol resistentes (BAAR) en frotis resulta un aporte significativo al diagnóstico y tratamiento de individuos con inflamación granulomatosa crónica (IGC). Con el objetivo de evaluar la presencia de BAAR en diferentes tejidos de pacientes con I...

  16. Trabajando fractales con Winlogo

    OpenAIRE

    Sabogal, Sonia; Arenas, Gilberto

    2007-01-01

    Después de una breve introducción en la cual se establecerán algunos conceptos teóricos básicos de la geometría fractal, se realizarán talleres en los cuales, con ayuda de las herramientas que trabaja el software WinLogo, se construirán diversos fractales, analizando sus principales características (autosimilitud, dimensión, etc.)

  17. Transporte forestal con cables

    OpenAIRE

    Anaya L. Héctor J.

    2012-01-01

    La explotación forestal es un problema fundamentalmente de transporte. El apeo y la preparación de las trozas, aunque a veces presentan algunas dificultades, son operaciones fáciles de resolver comparadas con la operación de transporte la cual absorbe del 60% al 70% o más del costo total del aprovechamiento del bosque. El 30% o 40% restante es absorbido por las faenas previas de apeo y troceo.

  18. Encuentros con Elena Poniatowska

    OpenAIRE

    Uzquiza González, José Ignacio

    2008-01-01

    El autor analiza, desde su encuentro con Elena Poniatowska, la vertiente de la literatura testimonial como literatura de mujeres. Un análisis interior de la relación entre realidad y ficción, entre Elena, Jesusa o Tinísima. The author analyzes testimonial literature from the perspective of female literature through his meeting with Elena Poniatowska. An analysis of reality vs. Fiction in Elena, Jesusa and Tinisima.

  19. pacientes con falla cardiaca

    Directory of Open Access Journals (Sweden)

    Diana Marcela Achury Saldaña

    2007-01-01

    Full Text Available Objetivo: determinar la adherencia al tratamiento de pacientes con falla cardiaca hospitalizados, al aplicar un plan educativo quefomenta el autocuidado.Método: estudio cuasiexperimental (entrevistas enfermera-paciente realizado entre diciembre de 2004 y mayo de 2006, con unamuestra de 50 pacientes seleccionados por conveniencia. Se diseñó un instrumento para evaluar los comportamientos de los pacientes,con base en algunos resultados de la adherencia y sus respectivos indicadores de la taxonomía NOC (Nursing out comes classification. Laadherencia al tratamiento fue medida en dos momentos: el primero durante la hospitalización, seguido de la aplicación del plan educativoantes del alta, que proporcionaba información en el manejo de su enfermedad desde una dimensión física, psicológica y social quepromueve el autocuidado; y el segundo un mes después del alta en su domicilio.Resultados: diferencias estadísticamente significativas (P=0,0001 que demuestran cómo mediante la capacitación al paciente enel manejo de su tratamiento farmacológico y no farmacológico, el establecimiento de una sana relación entre el profesional de enfermeríay el paciente, y la participación de la familia, se logra una total adherencia al tratamiento.Conclusiones: para lograr una adherencia total del paciente con falla cardiaca al tratamiento es necesario un proceso educativo y unseguimiento continuo y personalizado que motive permanentemente al paciente y se le reconozca el papel protagónico en su cuidado y manejo de la enfermedad.

  20. Lectura con adolescentes

    Directory of Open Access Journals (Sweden)

    Silvia Méndez Anchía

    2007-01-01

    Full Text Available Con base en la premisa de que la lectura de textos literarios tiene una función formadora y que esta se acentúa en la adolescencia, me propongo demostrar que el cuento “Rapunzel” puede utilizarse como estrategia para explorar algunas situaciones que los sujetos adolescentes perciben como particulares en relación con su vida, pero que se inscriben dentro de grandes problemáticas estudiadas por varias disciplinas. Para ello, he identificado, desde dos marcos de referencia (sociológico y psicoanalítico, diversas problemáticas y discursos que se desprenden de la lectura del cuento realizada por dos mujeres adolescentes, quienes respondieron una guía de lectura y participaron en una entrevista a profundidad. Concluyo que la lectura y comentario del cuento hacen posible que una serie de experiencias que los sujetos adolescentes viven como únicas (como el embarazo de una amiga, las críticas de las personas adultas y las exigencias de padres y madres, ingresen en el circuito de los conocimientos generales al relacionarlas con los discursos y problemáticas en que se inscriben (por ejemplo, el discurso de la “crisis” de la adolescencia, el enfoque de derechos humanos, el mundo fantasmático materno. Por ello, recomiendo la lectura y comentario de textos literarios como estrategia didáctica para contribuir a la elaboración de la subjetividad de personas adolescentes.

  1. 经直肠腔内超声诊断后尿道结石的临床价值%The Clinical Value of Transrectal Ultrasonography in Diagnosing Hind Urethra Calculus

    Institute of Scientific and Technical Information of China (English)

    李庆; 谢江凌

    2013-01-01

    目的 探讨经直肠腔内超声对后尿道结石的诊断价值.方法 对36例后尿道结石患者采用经直肠腔内超声检查,并将超声诊断结果与临床结果进行对比分析.结果 经直肠腔内超声检查诊断后尿道结石35例,误诊1例.后尿道结石中,位于后尿道前列腺部22例,后尿道膜部14例,经直肠腔内超声检查诊断后尿道结石符合率为97.22%.结论 经直肠腔内超声检查对后尿道结石的诊断率高,可为临床治疗提供可靠的依据,值得临床推广应用.%Objective To study the value of transrectal ultrasonography in diagnosing hind urethra calculus. Methods Using intracavity probe, combined with high frequency rectum transducer and line transducer necessary, to check the hind urethra calculus by transrectal ultrasonography. Results By transrectal ultrasonography, 35 cases have been diagnosed as hind urethra calculus, misdiagnosis 1 case, 22 as prostate calculus of hind urethra and 14 as membrane calculus of hind urethra,the coincidence rate is 97. 22%. Conclusion Transrectal ultrasonography can improve the diagnostic rate of hind urethra calculus, provide reliable basis for the clinical diagnosis and treatment, worthy of clinical application.

  2. Sentinel lymph node biopsy in patients with locally advanced breast cancer after neoadjuvant chemotherapy Biopsia do linfonodo sentinela em câncer na mama localmente avançado pós-quimioterapia neoadjuvante

    Directory of Open Access Journals (Sweden)

    Paulo Henrique Walter Aguiar

    2012-12-01

    Full Text Available PURPOSE: To check the rate of sentinel lymph node (SLN identification in patients with locally advanced breast cancer who underwent neoadjuvant chemotherapy comparing intraoperative contact cytology (imprint and embedded in paraffin and validation of methods. METHODS: A cross-sectional validation of diagnostic test involving 34 patients from the outpatient clinic of the Maternity School Assis Chateaubriand. The patients had locally advanced breast cancer and were treated with neoadjuvant chemotherapy. Those with clinically negative axilla underwent SLN biopsy, studied by imprint and histopathology in paraffin. All patients underwent axillary dissection and its histopathological study. RESULTS: The SLN identification rate was 85.3% (29/34. The sensitivity of imprint associated with paraffin on detection of metastasis compared to histopathology of the axillary content was 84.62% and specificity of 100% with false-negative rate of 12.01% and an accuracy of 92.77%. CONCLUSION: The search for metastases in the SLN by imprint and histopathological analysis in paraffin compared to the gold standard (axillary dissection had a low sensitivity with high rate of false negatives in our sample.OBJETIVO: Verificar a taxa de identificação do linfonodo sentinela (LS em pacientes portadoras de câncer na mama localmente avançado e que foram submetidos à quimioterapia neoadjuvante comparando a citologia de contato intraoperatória (imprint e a inclusão em parafina e validação dos procedimentos. MÉTODOS: Estudo transversal de validação de teste diagnóstico envolvendo 34 pacientes oriundas do Ambulatório da Maternidade-Escola Assis Chateaubriand. As pacientes eram portadoras de câncer na mama localmente avançado e foram tratadas com quimioterapia neoadjuvante. Àquelas com axila clinicamente negativa foram submetidas à biopsia do LS, esse estudado por impint e histopatologia em parafina. Todas as pacientes foram submetidas a esvaziamento axilar e seu

  3. High-frequency high-spatial resolution US in transplanted kidney in pediatric patients; Studio ecografico con sonda con alta frequenza ed elevata risoluzione spaziale nella valutazione del rene trapiantato nell'eta' pediatrica

    Energy Technology Data Exchange (ETDEWEB)

    Amodio, F.; Rossi, E.; Carbone, M.; Brunese, L.; Tamasi, S.; Vallone, G. [Neaples Univ. Federico 2, Neaples (Italy). Dipt. di Scienze Biomorfologiche e Funzionali; Mansueto, G.; Somma, P. [Neaples Univ. Federico 2, Neaples (Italy). Sezione di Anatomia Patologica e Citopatologica

    2000-02-01

    pazienti sono stati monitorizzati con valutazione della creatininemia, azotemia e diuresi nelle 24 ore. Nei 4 casi patologici e' stata eseguita biopsia renale eco-guidata. Dei 15 pazienti 11 avevano normale funzionalita' renale e 4 presentavano rigetto cronico. Nei pazienti con normale funzionalita' renale lo studio con power Doppler con sonda da 7,5 MHz ha permesso in tutti i casi la visualizzazione dei vasi interlobulari rappresentati dalla somma di una serie di segnali con lieve intensita' (effetto di sommazione); l'utilizzazione della sonda da 13MHz, in virtu' dell'elevata risoluzione laterale (<0,3 mm), ha consentito di suddividere il segnale vascolare nelle singole componenti (vasi interlobulari) e ha permesso ottimale mappattura della vascolarizzazione corticale. Nei pazienti con rigetto cronico l'esame con power Doppler consonda da 7,5 MHz ha mostrato scarsa vascolarizzazione corticale mentre con l'utilizzazione della sonda da 13 MHz e' stata rilevata in tutti i casi la presenza di vascolarizzazione ridotta e patologica evidenziando i vasi interlobulari tortuosi e con calibro ridotto. Lo studio del rene trapiantato con sonda da 13 MHz appare particolarmente adatto ai pazienti pediatrici per i ridotti spessori tissutali che permettono il passaggio di onde ultrasonore con alta frequenza. L'ottimale visualizzazione della vascolarizzazione corticale puo' permettere il riconoscimento precoce di tutte quelle condizioni (es. rigetto acuto e cronico) nelle quali la riduzione generalizzata della vascolarizzazione corticale si correla con il livelli di creatininemia.

  4. CE-Magnetic Resonance mammography for the evaluation of the contralateral breast in patients with diagnosed breast cancer; Ruolo della Risonanza Magnetica con Gd-BOPTA nella valutazione della mammella controlaterale in pazienti con tumore recentemente diagnosticato

    Energy Technology Data Exchange (ETDEWEB)

    Pediconi, Federica; Venditti, Fiammetta; Padula, Simona; Roselli, Antonella; Moriconi, Enrica; Catalano, Carlo; Passariello, Roberto [La Sapienza Univ., Roma (Italy). Dipartimento di scienze radiologiche; Giacomelli, Laura [La Sapienza Univ., Roma (Italy). Dipartimento di scienze chirurgiche

    2005-07-15

    negativa all'esame clinico, mammografico ed ecografico, sono stati studiati con un magnete operante ad 1,5 T. L'esame RM e stato eseguito utilizzando sequenze 3D dinamiche FLASH TI pesate prima e dopo la somministrazione di 0,1 mmol/kg di Gd-BOPTA. Il livello di sospetto della lesione e stato classificato su scala da 0 a 5 seguendo la classificazione BI-RADS. I risultati sono stati confrontati con l'esame istologico ottenuto dopo biopsia od intervento chirurgico. Risultati. La RM ha identificato la presenza di lesione contro laterale in 14 delle 50 pazienti (28%). La biopsia e stata eseguita su 4 di queste lesioni sospette (BI-RADS 4), mentre 10 pazienti sono state sottoposte ad intervento chirurgico poiche le lesioni presentavano caratteristiche fortemente sospette per malignita (BI-RADS 5). L'esame istologico ha diagnosticato tre fibroadenomi, cinque carcinomi duttali in situ, due carcinomi lobulari in situ, tre carcinorni duttali infiltranti ed un carcinoma lobulare invasivo. Utilizzando la RM sono stati ottenuti tre falsi positivi e nessun falso negativo. Conclusioni. La RM ha mostrato una elevata accuratezza diagnostica nella identificazione di tumori sincroni contro laterali in pazienti con tumore della mammella recentemente diagnosticato e potrebbe essere introdotta come esame di screening dei pazienti con tumore accertato prima di sottoporli ad intervento chirurgico.

  5. Cementos con cenizas volantes

    Directory of Open Access Journals (Sweden)

    Ossa M., Mauricio

    1984-03-01

    additions of 20 and 30% .

    Casi la generalidad de los estudios realizados sobre cementos con adición de cenizas volantes se refieren a sus características y comportamiento en pastas, morteros y hormigones, siempre en relación con aquéllos del cemento portland. Esta vez, se desarrolló un trabajo experimental orientado a relacionar entre sí los cementos con adiciones de cenizas volantes y de puzolana natural. Para ello se fabricaron a escala de laboratorio cementos de ambos tipos, empleando como materias primas comunes clinker y yeso y, como variables, diferentes porcentajes de las dos adiciones, que cumplieron previamente los requisitos normalizados en cuanto a sus actividades puzolánicas. La calidad de los cementos fabricados resultó adecuada y concordante con la del cemento portland-puzolánico obtenido a escala industrial con los mismos clinker, yeso y puzolana natural de este estudio. Posteriormente, se determinaron las características de los cementos experimentales y se confeccionaron morteros normales para la realización de ensayos físicos y mecánicos. Los resultados de ensayos indicaron que los cementos con adición de cenizas volantes (CCV requieren menos agua para consistencia normal, presentan tiempos de fraguado mayores y expansiones en autoclave menores que los cementos con adición de puzolana (CP. Los calores de hidratación a 7 y 28 días de edad fueron aproximadamente similares para ambos tipos de cemento. En morteros normales, los cementos CCV mostraron menor retracción de secado, mayor retentividad y mayor fluidez (para igual cantidad de agua que los cementos CP. En los ensayos de exudación se observó que ésta depende más de la finura que el tipo de adición. Finalmente, los ensayos mecánicos señalaron que las resistencias a compresión y flexotracción de los morteros con cementos CCV son menores a edades inferiores que 14 días (del orden de 5 a 10% a un día de edad, pero que a partir de entonces pasan a ser mayores que las de

  6. Role of information in preparing men for transrectal ultrasound guided prostate biopsy: a qualitative study embedded in the ProtecT trial.

    Science.gov (United States)

    Wade, Julia; Rosario, Derek J; Howson, Joanne; Avery, Kerry N L; Salter, C Elizabeth; Goodwin, M Louise; Blazeby, Jane M; Lane, J Athene; Metcalfe, Chris; Neal, David E; Hamdy, Freddie C; Donovan, Jenny L

    2015-02-28

    The histological diagnosis of prostate cancer requires a prostate needle biopsy. Little is known about the relationship between information provided to prepare men for transrectal ultrasound guided biopsy (TRUS-Bx) and how men experience biopsy. The objectives were a) to understand men's experiences of biopsy as compared to their expectations; and b) to propose current evidence-based information for men undergoing TRUS-Bx. Between February 2006 and May 2008, 1,147 men undergoing a standardised 10-core transrectal ultrasound guided biopsy protocol under antibiotic cover following a PSA 3.0-19.9 ng/ml in the Prostate Testing for Cancer and Treatment (ProtecT) trial, completed questionnaires about biopsy symptoms. In this embedded qualitative study, in-depth interviews were undertaken with 85 men (mean age 63.6 yrs, mean PSA 4.5 ng/ml) to explore men's experiences of prostate biopsy and how the experience might be improved. Interview data were analysed thematically using qualitative research methods. Findings from the qualitative study were used to guide selection of key findings from the questionnaire study in developing a patient information leaflet preparing men for biopsy. Although most men tolerated TRUS-Bx, a quarter reported problematic side-effects and anxiety. Side effects were perceived as problematic and anxiety arose most commonly when experiences deviated from information provided. Men who were unprepared for elements of TRUS-Bx procedure or its sequelae responded by contacting health professionals for reassurance and voiced frustration that pre-biopsy information had understated the possible severity or duration of pain/discomfort and bleeding. Findings from questionnaire and interview data were combined to propose a comprehensive, evidence-based patient information leaflet for TRUS-Bx. Men reported anxiety associated with TRUS-Bx or its side-effects most commonly if they felt inadequately prepared for the procedure. Data from this qualitative study and

  7. Atender con ansiedad

    Directory of Open Access Journals (Sweden)

    Alberto Acosta

    2009-10-01

    Full Text Available Tener una personalidad ansiosa o estar ansioso en una determinada situación hace que atendamos de modo diferente a lo que acontece. Investigaciones recientes están descubriendo las relaciones específicas de la ansiedad-rasgo y de la ansiedad-estado con diferentes procesos atencionales. La intervención terapéutica para aliviar los trastornos de ansiedad, tan frecuentes en nuestra época, se va a beneficiar de este conocimiento.

  8. Arquitectura con discurso

    OpenAIRE

    Schaposnik, Viviana

    2001-01-01

    En particular a la Carrera Arquitectura le compete un doble rol social: uno general, "educar" desde la Universidad y otro, específico, el que le es propio: dar respuesta a las necesidades planteadas por la sociedad haciéndole su lugar: construyéndolo junto con ella. Aparece la figura del "alumno de arquitectura"' nuestro destinatario específico. El alumno de arquitectura, también deberá tomar conciencia, entender, que el "espacio" que él deberá dominar a través d...

  9. Creo con mis dedos

    OpenAIRE

    S??nchez Aniceto, Monta??a

    2015-01-01

    Las artes pl??sticas son muy importantes para los ni??os/as sobre todo para Educaci??n Infantil ya que promueven la creatividad mediante diferentes recursos y t??cnicas lo que favorece su motivaci??n en las competencias desde la edad temprana hasta la adolescencia. Es la primera forma que tiene el ni??o/a de expresarse en el mundo (a trav??s de los garabatos), de comunicarse, compartir sus emociones con los dem??s, creando su propio lenguaje que evolucionar?? hacia el lenguaje oral y escri...

  10. Eugenistas, pero con prudencia

    Directory of Open Access Journals (Sweden)

    Pogliano, Claudio

    1999-12-01

    Full Text Available Thinking that one could not describe eugenics like a unique movement, since numerous bound varians took place related to the geographical and cultural context, this article tries to demostrate the peculiarity of the Italian case. If already in 1889 Giuseppe Sergi wanted that the artificial selection take it to end what should make the natural, avoiding the risk of the so called «degeneration», only in the face of the First World War seems to grow the alarm for the decadent quality of the population, finding a more and more wide echo. In 1919 the Siges was born (Società italiana de genetica ed eugenica shocked under the impression of the difusse fear about the butcher the war had caused. From there from now on fastens a «nazional» direction closely related to the traditional thought and also with the new political temper. A «moderate» direction, Fascist, Catholic, that was built in consonance with the pronatalism of the regime and in rough polemic with the presumed Anglo-Saxon eugenics aberration.

    Partiendo de la base de que no se puede describir la eugénica como un movimiento unitario, ya que se produjeron numerosas variantes ligadas al contexto geográfico y cultural, este artículo intenta demostrar la peculiaridad del caso italiano. Si ya en 1889 Giuseppe Sergi deseaba que la selección artificial llevase a cabo lo que debía de hacer la natural, evitando así el riesgo de la «degeneración », sólo ante la Primera Guerra Mundial parece crecer la alarma por la decadente calidad de la población, encontrando un eco cada vez más amplio. En 1919 nació la Sige (Società italiana de genetica ed eugenica bajo la impresión del difuso temor que la carnicería bélica había provocado. De ahí en adelante prende rápidamente una dirección «nazional» que se imbrica tanto con una tradición del pensamiento como con el nuevo temple político. Una dirección «moderada» fascista, católica, que se construyó en consonancia con el

  11. con problemas de aprendizaje

    Directory of Open Access Journals (Sweden)

    Claudia Jaquelina González Trujillo

    2007-01-01

    Full Text Available Un grupo de niños con diversos problemas de aprendizaje fue atendido bajo un programa de intervención de integración y adaptación social. Mejoras importantes se obtienen en competencias académicas bajo el presente programa de intervención y delimitan áreas de oportunidad para la mejora en aspectos cognitivos como el del proceso de atención e integración social. Las implicaciones de los resultados se discuten bajo un programa de apoyo psicopedagógico para la educación especial.

  12. Mayonesa con quitosano

    OpenAIRE

    Gaffrey, María Celeste

    2014-01-01

    Introducción: El quitosano es un polímero natural que se obtiene a partir de la quitina, la cual forma parte de la estructura de soporte de numerosos organismos vivos, tales como artrópodos (crustáceos e insectos), moluscos y hongos. Presenta propiedades aplicables en los alimentos, como estabilizante, emulsificante, y quelante. No puede ser digerido por los seres humanos por lo cual está considerado como una fibra dietética con un contenido calórico cero. Objetivos: Evaluar...

  13. con la cosecha mecanizada

    Directory of Open Access Journals (Sweden)

    Arturo Martínez Rodríguez

    2006-01-01

    Full Text Available Las investigaciones dirigidas a incrementar los indicadores de eficiencia y calidad durante la cosecha mecanizada del café, constituyen un tema de gran actualidad a nivel internacional. La determinación de las propiedades físico-mecánicas de los frutos y del sistema frutopedúnculo, es una etapa indispensable durante las investigaciones relacionadas con la cosecha mecanizada de este producto. En este trabajo se brindan los resultados sobre la determinación de un grupo de propiedades dimensionales, inerciales y elásticas del sistema fruto-pedúnculo de coffea arabica variedad Catuai en diferentes estadios de maduración, relacionadas con la cosecha mecanizada de este cultivo.Así mismo se determina el momento flector requerido para la ruptura de la unión fruto pedúnculo. Durante la investigación se emplearon técnicas de procesamiento de imágenes digitales, así como de extensometría eléctrica. Como resultado de la medición de las diferentes propiedades se apreciaron diferencias sustanciales en las características dimensionales, inerciales y elásticas de los frutos maduros y verdes, así como en el momento requerido para el desprendimiento de los frutos y en las formas en que se produce el desprendimiento.

  14. Entrevista con Giovanni Levi

    Directory of Open Access Journals (Sweden)

    Monica Oliveira

    2017-06-01

    Full Text Available En esta entrevista, Giovanni Levi - como un conocedor del tema de Familia - realiza una importante evaluación sobre el actual estado de las investigaciones realizadas en el Brasil y em el exterior. Con estilo franco, agudo y lucido critica las visiones tradicionales y sus ilusiones ypropone nuevos conceptos y métodos. La historia de la familia debería ceder espacio para el estudio de las redes relacionales o de los mundos relacionales. De la misma forma, la historia cuantitativa debería abrir espacio para el estudio de las cualidades. Ya con relación a la historia de las elites, tan estudiada y reproducida en una diversidad de trabajos, que deberíase mirar en otra perspectiva. Es decir, no mirar a las reglas sociales predeterminadas, sino a los desvíos y a las variaciones. Levi defiende que los historiadores deben trascender a los documentos que se encuentran fácilmente y que pueden fortalecer perspectivas deformadas y esequilibradas de la sociedad. Para él, los historiadores deben esforzarse por estudiar a aquellos grupos que dejaron pocos rastros documentales. En ese esfuerzo existiría una nueva mirada sobre la historia de la familia.

  15. Entrevista con Patricia Ariza

    Directory of Open Access Journals (Sweden)

    Esperanza Londoño La Rotta

    2017-01-01

    Full Text Available Pensamiento, Palabra y Obra entrevista a una artista, feminista y activista política, quien como mujer y artista ha permitido pensar el arte más allá de un simple espectáculo. Toda una vida dedicada al teatro y a darle voz, a través de sus obras, a víctimas del conflicto colombiano, defensora de derechos humanos; además de hacer evidente en su vida y a través de la plataforma “Artistas por la paz”, las múltiples relaciones que se pueden establecer entre el arte, la construcción de paz y la resolución de conflictos. Hablamos en su casa, en medio del calor de la bienvenida con Patricia Ariza, directora del festival alternativo de teatro, de Mujeres en Escena y de la Corporación Colombiana de Teatro, entre otras muchas actividades que voluntariamente su espíritu libertario ha asumido. Esta entrevista se realizó antes del 2 de octubre, pero con la revisión de los acuerdos que propició el plebiscito ganado por una ínfima minoría por el no, sigue siendo vigente este planteamiento.

  16. Entrevista con Geoffrey Lloyd.

    Directory of Open Access Journals (Sweden)

    Fernando Colina Pérez

    2008-01-01

    Full Text Available Helenista y también sinólogo de relieve internacional, Geoffrey E. R. Lloyd nació en Londres (1933, de padres galeses. Es un gran historiador de la ciencia y del pensamiento griegos. En 1940 fue evacuado de Londres con su madre. Sus estudios significativos comenzaron, tras algún rodeo, en el King’s College donde estudiaba su hermano. Éste sería, como su padre, médico, y él mismo dudó en estudiar esa profesión, que late en sus libros. Pero un profesor de clásicas como John Raven –que redactó, con Geoffrey Kirk, Los filósofos presocráticos–, le indujo a ocuparse de la filosofía antigua; y otro maestro, William Guthrie –a quien debemos la gran Historia de la filosofía griega–, le inició, además, en la medicina griega.

  17. Infección diseminada crónica con abscesos cerebralesmúltiples por Paracoccidioides brasiliensis Chronic disseminated infection with multiple cerebralabscesses caused by Paracoccidioides brasiliensis

    Directory of Open Access Journals (Sweden)

    Marcelo Corti

    2010-09-01

    Full Text Available La paracoccidioidomicosis es una micosis sistémica, endémica de áreas tropicales y subtropicales de América Central y del Sur, causada por un hongo dimorfo denominado Paracoccidioides brasiliensis. El compromiso del sistema nervioso central es una rara complicación de la forma diseminada crónica de la enfermedad y puede comprometer el cerebro, el cerebelo, el tronco cerebral y la médula espinal. La forma clínica más común de la neuroparacoccidioidomicosis es el granuloma o absceso cerebral y, con menos frecuencia, la meningoencefalitis crónica. Se presenta un paciente con diagnóstico de paracoccidioidomicosis diseminada crónica con múltiples lesiones cerebrales compatibles con abscesos. La biopsia estereotáxica seguida del estudio histopatológico y microbiológico del material obtenido de las lesiones permitió observar las levaduras redondeadas con los brotes característicos de Paracoccidioides brasiliensis.Paracoccidioidomycosis is an endemic systemic disease in subtropical areas of Central and South America caused by a dimorphic fungus Paracoccidioides brasiliensis. Central nervous system involvement is a rare complication of the chronic disseminated disease that can affect the brain, cerebellum, brainstem and the spinal cord. The most frequent clinical form of neuroparacoccidiodomycosis is the cerebral abscess; with less frequency, the disease presents as a diffuse chronic meningoencephalitis. Here we present a patient with diagnosis of disseminated paracoccidioidomycosis and multiple cerebral lesions compatible with abscesses. Stereotactic biopsy followed by the microbiological and histopathological examination of the smears showed the characteristic yeast cells that confirmed the diagnosis of neuroparacoccidioidomycosis.

  18. Oligodendroglioma in a patient with AIDS: case report and review of the literature Oligodendroglioma en un paciente con sida: reporte de caso y revisión de la literatura

    Directory of Open Access Journals (Sweden)

    Marcelo E. Corti

    2004-08-01

    Full Text Available In the last years, new techniques of neuroimages and histopathological methods have been added to the management of cerebral mass lesions in patients with AIDS. Stereotactic biopsy is necessary when after 14 days of empirical treatment for Toxoplasma gondii encephalitis there is no clinical or neuroradiologic improvement. We report a woman with AIDS who developed a single focal brain lesion on the right frontal lobe. She presented a long history of headache and seizures. After two weeks of empirical treatment for toxoplasma encephalitis without response, a magnetic resonance image with spectroscopy was performed and showed a tumoral pattern with a choline peak, diminished of N-acetyl-aspartate and presence of lactate. A stereotactic biopsy was performed. Histopathological diagnosis was a diffuse oligodendroglioma type A. A microsurgical resection of the tumor was carried out and antiretroviral treatment was started. To date she is in good clinical condition, with undetectable plasma viral load and CD4 T cell count > 200 cell/uL.En los últimos años, las nuevas técnicas de neuroimágenes y diversos métodos de diagnóstico histopatológico se han agregado al manejo clínico de las lesiones de masa cerebral ocupante en los pacientes con sida. La biopsia estereotáxica es necesaria cuando, luego de dos semanas de tratamiento empírico para toxoplasmosis cerebral, no se comprueba mejoría clínica ni neurorradiológica. Presentamos una paciente con sida que desarrolló una lesión cerebral a nivel del lóbulo frontal derecho. Como antecedente refirió una larga historia de cefalea y convulsiones. La resonancia nuclear magnética con espectroscopia de voxel único ubicado a nivel de la lesión mostró un patrón de lesión tumoral con pico de colina, déficit de N-acetil-aspartato y presencia de ácido láctico. La biopsia estereotáxica y el estudio histopatológico permitieron arribar al diagnóstico de oligodendroglioma difuso de tipo A. Se le

  19. A 56-year-old woman with ampullary adenocarcinoma and acute pancreatitis Mujer de 56 años con adenocarcinoma de la ampolla de Vater y pancreatitis aguda

    Directory of Open Access Journals (Sweden)

    V. M. Santos

    2012-12-01

    Full Text Available A 56-year-old woman was admitted with jaundice, and laboratory data were indicative of pancreatitis, which recurred in spite of adequate clinical and nutritional management. The patient was an overweight diabetic using metformin, who had antecedents of cholelithiasis and recent cholecystectomy. Clinical and laboratory features were not conclusive about the cause of this acute pancreatitis. However, imaging data contributed to diagnosis suspicion, and the histopathology study of the transpapillary biopsy confirmed the ampullary adenocarcinoma. Whipple´s surgery was the procedure of choice, associated with radical lymphadenectomy, followed by an uneventful outcome. Recrudescence of signs and symptoms of acute pancreatitis, with elevated serum levels of bilirrubins and of hepatic canalicular enzymes, should enhance the suspicion index about periampullary tumors. High levels of CA 19-9 can constitute a useful marker of this condition. Transpapillary biopsy can characterize the diagnosis of ampullary malignancies.Se presenta el caso de una mujer de 56 años, que presentaba ictericia y cuyos exámenes de laboratorio fueran indicativos de pancreatitis. Presentó recurrencia a pesar de las medidas clínicas y nutricionales adecuadas. La paciente era diabética, con sobrepeso, tomaba metformina y con antecedentes de colelitiasis y reciente colecistectomía. Los datos clínicos y del laboratorio no fueron concluyentes acerca del origen de esta pancreatitis aguda. Sin embargo, los estudios de imagen contribuyeron a la sospecha del diagnóstico; los estudios de citologia exfoliativa y de biopsia transpapilar confirmaron un adenocarcinoma ampular. La cirugía de Whipple fue el procedimiento de opción, asociado con linfadenectomía radical, con resultado favorable. El recrudecimiento de señales y síntomas de pancreatitis aguda, con niveles séricos elevados de bilirrubina y de enzimas hepáticos debe reforzar el índice de sospecha acerca de tumores

  20. Fluoroquinolone-resistant E. coli in intestinal flora of patients undergoing transrectal ultrasound-guided prostate biopsy--should we reassess our practices for antibiotic prophylaxis?

    Science.gov (United States)

    Steensels, D; Slabbaert, K; De Wever, L; Vermeersch, P; Van Poppel, H; Verhaegen, J

    2012-06-01

    Although the estimate of the incidence of sepsis following transrectal ultrasound-guided prostate biopsy (TRUSPB) is low, fluoroquinolone-resistant infections after prostate biopsy are being increasingly noted. This study was aimed at determining the prevalence of faecal carriage of fluoroquinolone-resistant Escherichia coli strains before TRUSPB and at evaluating potential predisposing risk factors. The incidence of sepsis after prostate biopsy was determined, and our routine practice for antibiotic prophylaxis for TRUSPB was evaluated. A prospective study was conducted in 342 consecutive patients undergoing prostate biopsy between December 2009 and July 2010. Before TRUSPB, a rectal swab was cultured. The correlation between the presence of fluoroquinolone-resistant strains and plausible risk factors was investigated by the use of a questionnaire. Of the 236 patients included, 22.0% (52/236) harboured ciprofloxacin-resistant E. coli strains. The use of fluoroquinolones in the 6 months before biopsy was associated with an increased risk of faecal carriage of fluoroquinolone-resistant E. coli strains (p fluoroquinolone-resistant E. coli strains was an important risk factor for infectious complications after TRUSPB (p fluoroquinolone-resistant E. coli strains (22.0%) before TRUSPB. The use of fluoroquinolones in the previous 6 months before biopsy is a risk factor for faecal carriage of fluoroquinolone-resistant E. coli strains and for infectious complications after TRUSPB. Hence, the universal administration of fluoroquinolones should be reconsidered. © 2011 The Authors. Clinical Microbiology and Infection © 2011 European Society of Clinical Microbiology and Infectious Diseases.

  1. Impact of preoperative screening for rectal colonization with fluoroquinolone-resistant enteric bacteria on the incidence of sepsis following transrectal ultrasound guided prostate biopsy

    Science.gov (United States)

    Farrell, John J; Hicks, Jennifer L; Wallace, Stephanie E; Seftel, Allen D

    2017-01-01

    With the universal adoption of antibiotic prophylaxis prior to prostate biopsy, the current risk of post-biopsy infection (including sepsis) is study of preoperative rectal cultures to screen for rectal colonization with fluoroquinolone-resistant bacteria using ciprofloxacin-supplemented MacConkey agar culture media. To evaluate the feasibility and practicality of this test, one provider used the results of rectal swab cultures collected during the preoperative outpatient evaluation to adjust each patient’s preoperative antibiotic prophylaxis when fluoroquinolone-resistant enteric bacteria were detected, whereas two other providers continued usual preoperative care and empiric antimicrobial prophylaxis. Rectal colonization with fluoroquinolone-resistant bacteria was detected in 19/152 (12.5%) of patients. In our intention-to-treat analysis (N=268), the rate of post-biopsy sepsis was 3.6% lower in the group that was screened for rectal colonization with fluoroquinolone-resistant bacteria prior to transrectal prostate biopsy. The observed risk reduction in the rectal screening group trended toward, but did not achieve, statistical significance. We suggest that preoperative screening for rectal colonization with fluoroquinolone-resistant enteric bacteria may be a useful step toward mitigating post-prostate biopsy sepsis. PMID:28280717

  2. Prostate cancer detection upon transrectal ultrasound-guided biopsy in relation to digital rectal examination and prostate-specific antigen level: what to expect in the Chinese population?

    Directory of Open Access Journals (Sweden)

    Jeremy YC Teoh

    2015-01-01

    Full Text Available We investigated the prostate cancer detection rates upon transrectal ultrasound (TRUS-guided biopsy in relation to digital rectal examination (DRE and prostate-specific antigen (PSA, and risk factors of prostate cancer detection in the Chinese population. Data from all consecutive Chinese men who underwent first TRUS-guided prostate biopsy from year 2000 to 2013 was retrieved from our database. The prostate cancer detection rates with reference to DRE finding and PSA level of 50 ng ml−1 were investigated. Multivariate logistic regression analyses were performed to investigate for potential risk factors of prostate cancer detection. A total of 2606 Chinese men were included. In patients with normal DRE, the cancer detection rates were 8.6%, 13.4%, 21.8%, 41.7% and 85.2% in patients with PSA 50 ng ml−1 respectively. In patients with abnormal DRE, the cancer detection rates were 12.4%, 30.2%, 52.7%, 80.6% and 96.4% in patients with PSA 50 ng ml−1 respectively. Older age, smaller prostate volume, larger number of biopsy cores, presence of abnormal DRE finding and higher PSA level were associated with increased risk of prostate cancer detection upon multivariate logistic regression analyses (P < 0.001. Chinese men appeared to have lower prostate cancer detection rates when compared to the Western population. Taking the different risk factors into account, an individualized approach to the decision of TRUS-guided biopsy can be adopted.

  3. Application of transrectal ultrasound-guided repeat needle biopsy in the diagnosis of prostate cancer in Chinese population: A retrospective study

    Directory of Open Access Journals (Sweden)

    Yi Wang

    2016-01-01

    Full Text Available Background: Transrectal ultrasound-guided repeat needle biopsy (TUGRNB is widely used for diagnosis of prostate cancer (PCa. However, significance of TUGRNB in Chinese population was rarely reported. A retrospective study was conducted to evaluate the significance of TUGRNB applied in prediction of PCa in Chinese population. Materials and Methods: A total of 960 from January 2009 to December 2012 were included. Repeat needle biopsy rate and PCa positive detection rate were evaluated. Relationship between prostate specific antigen (PSA levels and PCa positive rates was analyzed. Results: PCa positive detection rate after initial needle biopsy was 28.4%, which was lower than the rate of repeat needle biopsy (40%. The rate for immediate transurethral resection (TUR, surgery after initial needle biopsy, was 27.1%, however with a low PCa positive detection rate (0.66%. The repeat needle biopsy rate was lower compared with the initial biopsy rate (P 20 ng/ml, PCa positive rate was significantly higher than those with PSA < 20 ng/ml (P < 0.05. Conclusion: PCa positive detection rate following repeat needle biopsy in Chinese population was higher, although the repeated needle biopsy rate was still in a low level. TUGRNB should attract more attention in the diagnosis of PCa.

  4. Limiting overdiagnosis of low-risk prostate cancer through an evaluation of the predictive value of transrectal and power Doppler ultrasonography.

    Science.gov (United States)

    Sauvain, Jean Luc; Sauvain, Elise; Papavero, Roger; Louis, Didier; Rohmer, Paul

    2016-12-01

    Overdiagnosis induced by prostate cancer screening makes necessary a better selection of candidate patients for prostate biopsy. The objective of our study is to assess the probability of having a high- or low-risk lesion that could require active surveillance (AS) after biopsies and a normal or abnormal examination, including transrectal and power Doppler ultrasonography (TRUS-PDS). Four hundred and twenty-nine consecutive patients with a PSA level risk of a biological recurrence and Dall'Era's criteria to assess possible AS. The TRUS-PDS was considered positive if one biopsy was positive in the same sextant as the suspect image. One hundred and seventy-seven out of 429 (41 %) T1c cancers were diagnosed; 131 out of 177 (74 %) could be qualified as low risk, and 119 out of 177 (67 %) could require AS. The TRUS-PDS was normal in 285 of 429 patients (66 %). With a normal TRUS-PDS, the probability of not having cancer with a high or intermediate risk was 96 % (negative predictive value). With an abnormal TRUS-PDS, the probability of having a positive biopsy was 59 %, and the probability of having a significant cancer was 30 %, according to the Dall'Era criteria. When TRUS-PDS was normal, these probabilities significantly decreased to 32 and 5 %, respectively (p risk of high- or intermediate-risk cancer.

  5. The effects of transrectal radiofrequency hyperthermia on patients with chronic prostatitis and the changes of MDA, NO, SOD, and Zn levels in pretreatment and posttreatment.

    Science.gov (United States)

    Gao, Mingdong; Ding, Hui; Zhong, Ganping; Lu, Jianzhong; Wang, Hanzhang; Li, Qinfang; Wang, Zhiping

    2012-02-01

    To assess the effect of transrectal radiofrequency hyperthermia (TRFH) in 159 patients with chronic prostatitis (CP) and explore the changes of reactive oxygen species in CP patients pretreatment and posttreatment. Patients diagnosed with CP were randomized to 6 weeks of tamsulosin plus clarithromycin, TRFH, or TRFH with tamsulosin plus clarithromycin group. The primary outcome measure was evaluated by the National Institutes of Health Chronic Prostatitis Symptom Index. Malondiadehyde (MDA), superoxide dismutase (SOD), and nitrogen monoxide (NO) were measured by biochemical assay. Zinc (Zn) content was assayed by atomical spectrophotography. All 105 patients in the TRFH or TRFH with tamsulosin plus clarithromycin group showed statistically significant improvement of pain, quality of life, and micturition domains compared with the tamsulosin plus clarithromycin group. Regardless of type IIIa or type IIIb CP, there was a significant improvement in the TRFH or TRFH with tamsulosin plus clarithromycin group compared with tamsulosin plus clarithromycin group (Ppatients suggest that these factors could be used as a biomarker to evaluate the symptoms of CP and the effects of treatment. Copyright © 2012. Published by Elsevier Inc.

  6. Visual pain score during transrectal ultrasound-guided prostate biopsy using no anaesthesia or three different types of local anaesthetic application.

    Science.gov (United States)

    Gurbuz, Cenk; Canat, Lutfi; Bayram, Guner; Gokhan, Atis; Samet, Gungor; Caskurlu, Turhan

    2010-09-01

    To evaluate the pain score during transrectal ultrasound (TRUS)-guided prostate biopsy using three different anaesthetic applications and no anaesthesia. One-hundred men undergoing TRUS-guided prostate biopsy were prospectively enrolled in this study. Patients were randomized to four groups. Group 1 (n = 25) received no anaesthesia, group 2 (n = 25) was administered a perianal lidocaine injection, group 3 (n = 25) was administered a periprostatic lidocaine injection, and group 4 (n = 25) was administered a combination of perianal-intrarectal lidocaine-prilocaine cream. The anaesthetic application was given 5 min before the procedure. All patients were asked to indicate the level of pain experienced on a visual analogue scale (VAS) during three situations, including when the TRUS probe was inserted and 15 min and 2 weeks after biopsy. Mean pain scores were similar in all groups at the time of probe insertion. Mean pain scores showed statistically significant differences between group 1 and the other groups, except for group 4, 15 min after the procedure. Group 3 showed better pain control 15 min after biopsy and this difference was statistically significant (p biopsy may be advocated. The application of periprostatic lidocaine seems to be the most advantageous method for lowering the perception of pain.

  7. Análisis ultraestructural de la formación ósea en relación con el OsteoGen®

    Directory of Open Access Journals (Sweden)

    C. López Valenzuela

    2002-04-01

    Full Text Available El OsteoGen®, ha sido profusamente utilizado como material osteoconductor en cirugía periodontal. Sin embargo las características estructurales de la interfase y del hueso neoformado han sido escasamente evaluadas en el ser humano. Con el objeto de estudiar la calidad de la reparación ósea alrededor de OsteoGen®, se injertó el material en defectos óseos de dos pacientes . Las biopsias fueron tomadas a los 6 y 12 meses y procesadas para microscopía optica ( MO y electrónica de transmisión ( MET . Los resultados con MO a los seis meses demuestran una clara osteoconducción, lo que se hace notorio a los doce meses practicamente para todas las partículas.OsteoGen®, has been widely used as osteoconductor material in periodontal surgery. Neverthelees the structural characteristic of the interfase and neoformated bone have scarcely assessed in human being. In order to be able to study the quality of the bone repairing around OsteoGen®, the material was grafted in bone defects in two patients. The biopsies were taken after 6 months and 12 months and processed for optical microscopy (mo and electronic transmission (met. The results with mo after 6 months show a clear osteoconduction, which is noticiable at 12 months in practically all the particles.

  8. Entrevista con Juan Marichal.

    Directory of Open Access Journals (Sweden)

    - Consejo de Redacción

    1997-01-01

    Full Text Available Juan Marichal nació en Santa Cruz de Tenerife, en 1922, en el seno de una familia ligada al partido republicano insular. Muy joven, en 1935, se trasladó a Madrid, ciudad en la que vive el estallido de la guerra civil. En 1937, pasa a Valencia y luego a Barcelona; tras su exilio en 1938, prosigue sus estudios secundarios en un liceo de París, concluyéndolos en Casablanca. En 1941 emigra a México, formándose en la UNAM: fue alumno de los exiliados José Gaos y Joaquín Xirau así como del mexicano Edmundo O 'Gorman. Luego, becado en Princeton desde 1946, lo fue de América Castro, donde preparó una tesis sobre Feijoo. Apoyado en las vastas perspectivas de sus maestros, fue orientándose hada nuestra historia intelectual, desde el siglo XV hasta hoy. Su carrera profesional se ha desarrollado en los Estados Unidos (coincidiendo con Amado Alonso y con Ferrater Mora: ha sido profesor de estudios hispánicos en la Universidad de Harvard, desde 1948 hasta 1988, año en que se jubiló voluntariamente como numerario (aunque había permanecido en el Bryn Mawr College, entre 1953 y 1957. A este trabajo se suman, con todo, sus conferencias en América Latina y en España. Ha colaborado en las revistas más importantes, en este campo, de México, Nueva York, Puerto Rico, La Habana, Buenos Aires o París así como de las españolas, desde los sesenta. Juan Marichal -hoy, miembro de la Junta Directiva de los Amigos de la Residencia de Estudiantes, director del Boletín de la Institución Libre de Enseñanza y asociado al Instituto Universitario Ortega y Gasset-, reside en España desde otoño de 1989: se considera a sí mismo «voluntario en Madrid», como había dicho Alfonso Reyes en su estancia madrileña (1914-1924.

  9. Segurança e eficácia da técnica de biopsia pulmonar transtorácica percutânea para avaliação histopatológica do parênquima pulmonar de ovinos clinicamente sadios Safety and effectiveness of the transthoracic percutaneous lung biopsy technique for histopathological evaluation of the lung parenchyma in healthy sheep

    Directory of Open Access Journals (Sweden)

    Andreza Amaral da Silva

    2010-04-01

    Full Text Available Foram analisados os resultados e complicações decorrentes do emprego da técnica de biopsia pulmonar transtorácica percutânea em 20 ovinos clinicamente sadios. Os animais foram submetidos ao exame clínico seguido da biopsia com agulha semi-automática no 7º espaço intercostal direito, 5cm acima do olécrano. Foram analisados o número de tentativas para a execução do procedimento e o tamanho dos fragmentos. As amostras obtidas foram avaliadas histologicamente. Posteriormente ao abate, foi realizado o exame pos mortem para avaliação de complicações da técnica e das eventuais lesões provocadas. Entre todos os animais submetidos à biopsia apenas dois demonstraram resistência a técnica, sendo obtidos fragmentos pulmonares de 4-7mm de comprimento, com média de 1,8±1 tentativas por fragmento. As principais alterações relacionadas à técnica foram tosse, dispnéia inspiratória, elevação das freqüências cardíaca e respiratória e aumento do ruído broncobronquiolar. Ao exame post mortem observou-se hemorragia dos músculos intercostais e pleura visceral em todos os animais. Das 20 tentativas de execução da técnica, 18 obtiveram sucesso, enquanto que em duas o fígado foi equivocadamente puncionado. As amostras de tecido pulmonar foram consideradas representativas, pois foi possível a visualização de estruturas íntegras, incluindo bronquíolos e alvéolos. Podemos concluir que a biopsia pulmonar é segura e eficaz para obtenção de amostras pulmonares com fins de diagnóstico histológico.The results and complications arising from use of the percutaneous transthoracic lung biopsy technique in 20 clinically healthy sheep were analyzed. The animals were subjected to clinical examination followed by lung biopsy with a semi-automatic needle in the 7th right intercostal space, 5cm above the olecranon. The number of attempts to implement the procedure and size of the fragments were evaluated. The samples were evaluated

  10. Mirando con la cabeza

    OpenAIRE

    Corrales, Capi

    2006-01-01

    Las matemáticas y la pintura trabajan con ideas. La palabra idea viene del griego ειδω, que significa ver, mirar u observar, y de ειδοζ, que significa figura, forma, aspecto o visión. Detrás de una montaña concreta está la idea de montaña, un dibujo abstracto, unas líneas que permiten reconocer la montaña detrás de las rocas, los pinos o la nieve. La diferencia entre este árbol y árbol, entre un círculo que dibujamos en la pizarra y círculo: la diferencia entre la cosa y la idea de la cosa. E...

  11. Musicalizarte con las Tics

    OpenAIRE

    Gamarra, Patricia Mabel; Velázquez, Helvecia Mercedes del Rocío; Verón, José María

    2015-01-01

    El presente trabajo hace referencia a un relato de experiencia didáctica desarrollada en el Instituto Superior de Música “Prof. Carmelo H. de Biasi” de Corrientes- Argentina, donde el área de interés de Tecnología en Educación se dirige hacia “Aplicación de las TIC en Educación/ Experiencias concretas de utilización de TIC en Educación”. En el diagnóstico realizado en la institución, se pudo observar la escasa transversalidad e interrelación con las distintas áreas curriculares como ser: l...

  12. Entrevista con Georges Duby.

    Directory of Open Access Journals (Sweden)

    - Consejo de Redacción

    1994-01-01

    Full Text Available Duby, heredero de dos grandes historiadores como Marc Bloch y Lucien Febvre, es uno de los más importantes medievalistas europeos. Fue, y sigue siendo, un motor de la importante reforma en la historia producida desde los sesenta. En sus primeros trabajos se acusa la recepción de las ideas económicas y geográficas de la mejor historiografía. Su riguroso estudio sobre la base material de la Edad Media, le permitirá luego irrumpir en la historia de las mentalidades, analizando, como decía Febvre, el utillaje mental (vocabulario, sintaxis, lugares comunes, cuadros lógicos, etc. del Medioevo. Así, el ejemplo de Mauss y LéviStrauss le anima a trabajar sobre el matrimonio, la sexualidad y ciertos sistemas del pensamiento: el primero, con su defensa de los hechos sociales totales, y el segundo, que buscaba las dimensiones simbólicas de lo social, le impulsan a trabajar sobre la ideología entendida no como mero reflejo de la situación material sino como «proyecto de acción sobre lo vivido». A su obra individual, atenta a los impulsos culturales más vivos, se suma su empuje decisivo en la realización de proyectos colectivos como la Historia de la vida privada o la Historia de las mujeres. Prácticamente, han sido traducidos todos sus libros al castellano, y han podido verse en España asimismo varios de sus programas televisivos (ha sido presidente de la SEPT, cadena de televisión cultural fundada en 1985. La amplitud de sus intereses intelectuales, transmitidos en su obra con un lenguaje a la vez muy claro y bellamente elaborado, se hace palpable también en este diálogo.

  13. Sensibilidad in vitro a amoxicilina y claritromicina de Helicobacter pylori obtenido de biopsias gástricas de pacientes en zona de bajo riesgo para cáncer gástrico

    Directory of Open Access Journals (Sweden)

    Mercedes Figueroa

    2012-03-01

    Conclusiones. Los resultados de este estudio indican que es alta la incidencia de H. pylori resistente a claritromicina y amoxicilina en pacientes de Tumaco con gastritis crónica. También, se encontraron cepas multirresistentes a claritromicina y amoxicilina.   DOI: http://dx.doi.org/10.7705/biomedica.v32i1.454

  14. Inflamación Granulomatosa Crónica: Métodos de detección de bacilos ácido alcohol resistentes en biopsias embebidas en parafina

    National Research Council Canada - National Science Library

    Bustamante Rengifo Javier Andres; Bravo Ocaña Luis Eduardo; Pazos Mocayo Alvaro Jairo; Astudillo Hernadez Miryam

    2010-01-01

    ... años, con IGC demostrada y remitidos al departamento de patología del Hospital Universitario del Valle entre el 2002-2008, a cada muestra se le realizaron 3 cortes y se sometieron a tinciones de H/E, Zielh Neelsen y Auramina. La...

  15. preescolares desnutridos con madres con obesidad y sin obesidad

    Directory of Open Access Journals (Sweden)

    Viridiana Vanessa Conzuelo-González

    2009-01-01

    Full Text Available El primer objetivo fue conocer cuántos menores de cinco años con diferentes grados de desnutrición tienen una madre con sobrepeso/obesidad/ en una comunidad indígena que vive en extrema pobreza y bajo condiciones de migración masculina internacional. El segundo fue comparar tres variables socionutricionales (ingreso familiar, educación de la madre y adecuación nutrimental de la dieta diaria entre estos hogares y los hogares con desnutrición infantil y madres sin obesidad. Se realizó un estudio transversal (2006-2007, en la comunidad mazahua de San Francisco Tepeolulco, Municipio de Temascalcingo; que incluyó a 85 hogares integrados por preescolares con desnutrición inscritos al programa Oportunidades. Se determinó el estado nutrición de los preescolares con indicadores antropométricos y se obtuvo el IMC de las madres de estos infantes. Se aplicó una encuesta socionutricional, incluida el recordatorio de 24 horas, y complementado con la observación participante (cualitativa. Se encontró que 83% de las madres mazahuas presentaron sobrepeso u obesidad. El estado de nutrición de los preescolares con madres con obesidad presentó un porcentaje mayor de desnutrición (76%. En la variable género, se encontró que 54% de los niños con madres con obesidad tenía baja talla. Al relacionar el nivel educativo de la madre, esta variable resultó ser estadísticamente significativa (p=0.015, donde el analfabetismo está más relacionado con la desnutrición infantil que tienen madres de bajo y/o peso normal. La elevada prevalencia de hogares conformados con preescolares con desnutrición y madres con obesidad, es un síntoma más de la pobreza en zonas indígenas en México, con bajo índice de desarrollo humano.

  16. Vigas preesforzadas con refuerzo externo

    Directory of Open Access Journals (Sweden)

    Juan José Ferrer Narvaez

    2011-01-01

    Full Text Available Es de gran interés para la ingeniería colombiana el efecto del refuerzo externo de elementos estructurales con elementos metálicos. La Unidad de Estructuras ha venido realizando en el transcurso de esta década estudios en elementos en concreto con refuerzos externos a flexión con resultados satisfactorios. El proyecto ''Vigas preesforzadas con refuerzo externo" sirve de base en el estudio del comportamiento de este tipo de elementos estructurales y la extrapolación de los resultados obtenidos en elementos de concreto reforzado a concreto preesforzado.

  17. Utilidad de la elastografía de transición (Fibroscan® en la evaluación de la fibrosis hepática en pacientes con hepatopatía crónica Usefulness of transient elastography (Fibroscan® in the assessment of fibrosis in patients with chronic liver disease

    Directory of Open Access Journals (Sweden)

    Daniel Álvarez

    2012-02-01

    Full Text Available El pronóstico de la enfermedad crónica hepática depende de la extensión y la progresión de la fibrosis hepática. Actualmente la biopsia hepática es la técnica de elección para determinar el grado de fibrosis, pero es una prueba invasiva, no exenta de complicaciones. Por ello, el desarrollo de marcadores no invasivos de fibrosis hepática se convirtió en una necesidad indiscutible. Se propuso la elastografìa por transición (Fibroscan® para valorar la fibrosis hepática en pacientes con enfermedad crónica hepática, mediante la medición de la rigidez hepática. Nuestro objetivo fue evaluar la efectividad, la objetividad y la seguridad de esta técnica. Se estudiaron 68 pacientes a los que se les realizó una biopsia hepática en los 18 meses previos al estudio. Todos los procedimientos de elastografia y biopsia hepática fueron analizados por un mismo profesional (DA y MA, respectivamente. Para la valoración de la biopsia hepática se utilizó la escala METAVIR. El valor medio de rigidez en pacientes sin fibrosis o con fibrosis leve (F0-F1 y en los pacientes con fibrosis avanzada o cirrosis (F3-F4 fue 6.8 ± 3.0 kPa y 21.0 ± 15.1 kPa, respectivamente (con diferencia significativa, p The prognosis and management of chronic liver disease largely depends on the extent and progression of liver fibrosis. Unfortunately, liver biopsy, an invasive and painful technique with several limitations, continues to be the gold standard for the staging and grading of fibrosis. Therefore, accurate noninvasive tests for liver injury are urgently needed. During the last years, transient elastography (Fibroscan® has been proposed for the assessment of hepatic fibrosis in patients with chronic liver disease, by measuring liver stiffness. The aim of this study was to evaluate the effectiveness, objectivity and safety of this technique. We included 68 patients who underwent a liver biopsy in the last 18 months with a wide spectrum of chronic liver

  18. Entrevista con Giovanni Levi.

    Directory of Open Access Journals (Sweden)

    - Consejo de Redacción

    1999-01-01

    Full Text Available Nacido en Milán en 1939, Giovanni Levi, el importante y original historiador italiano, es heredero de una tradición familiar de grandes defensores de la libertad tanto cultural como política. En su práctica investigadora late siempre, de hecho, la memoria de un momento tan crítico de la historia italiana como el final del fascismo. Por añadidura, sus antepasados son judíos del Piamonte. Esta experiencia vital y las luchas sociales de los sesenta han marcado su quehacer como historiador y como estudioso. Levi, reconocido en Italia y asimismo en Europa y América, fue profesor en la Universidad de Turín y luego en la de Viterbo; actualmente es catedrático de Historia económica en Venecia, ejerciendo como profesor visitante en Francia. Su trabajo, muy creativo, aborda aspectos de la historia de la familia, la demografía y la agricultura en los siglos XVII y XVIII, pero su crítica como intelectual comprometido con el dudoso presente desborda su estricto ámbito de estudio.

  19. Tumor de Pindborg relacionado con trauma facial Pindborg's tumor in relationship with facial traumata

    Directory of Open Access Journals (Sweden)

    Niorgy Rodríguez Rodríguez

    2011-12-01

    Full Text Available El tumor de Pindborg es una neoplasia benigna, rara, con carácter invasivo local y tendencia a la recidiva, que representa entre el 0,17 y el 1,8 % de todos los tumores odontogénicos, del cual tan solo se han publicado unos 200 casos, con una media de 4 casos nuevos por año en el mundo. Se presentó el caso de un hombre de 39 años de edad que acudió a la consulta de cirugía maxilofacial remitido de neurocirugía postraumatismo craneofacial, por presentar un aumento de volumen en el ángulo mandibular derecho. Se tuvo como objetivo publicar la existencia de esta infrecuente neoplasia por lo interesantes que resultan estos tumores por su evolución, dificultad en el diagnóstico, variantes de tratamiento y tendencia a la recidiva. Después de realizar exámenes de laboratorio, radiografías, tomografía axial computarizada y biopsia de fragmento óseo, se obtuvo extensión y diagnóstico de tumor de Pindborg en hemimandíbula derecha. Se realizó la técnica quirúrgica de hemimandibulectomía derecha y reconstrucción con injerto óseo de cresta ilíaca. La evolución del paciente fue satisfactoria.The Pindborg's tumor is a benign and uncommon neoplasm with a local invasive character and a trend to relapse accounting for the 0.17 and the 1.8 % of all odontogenic tumors with only 200 cases published in the literature and a mean of four cases per year at world scale. This is the case of a man aged 39 came our consultation of Maxillofacial Surgery referred from Neurosurgery Service after a craniofacial trauma and an increase of volume in right mandibular angle with the aim to publish the existence of this uncommon neoplasm due to the interesting of this type of tumor by its evolution, difficulty for diagnosis, variants of treatment and trend to relapse. After carry out laboratory examinations, X-rays, axial tomography computerize and biopsy of bone fragment, it was possible the extension and diagnosis of Pindbog's tumor in right hemi

  20. Sarcoidosis: experiencia con 15 casos en el Hospital Calderón Guardia

    Directory of Open Access Journals (Sweden)

    José Mainieri-Hidalgo

    2002-06-01

    Full Text Available La sarcoidosis es una enfermedad que se diagnostica con poca frecuencia en Costa Rica; en 1988 fueron informados 6 casos en el Hospital San Juan de Dios. En este estudio se da cuenta de las características clínicas y el manejo de 15 pacientes del Hospital Calderón Guardia, diagnosticados entre 1987 y 2001. Todos los casos fueron de localización torácica y en doce de ellos la enfermedad afectó solamente los ganglios del mediastino, por lo que la radiografía de tórax fue el método de detección . Los síntomas más frecuentes fueron tos y disnea. La mediastinoscopía fue el método más utilizado para obtener la biopsia. El diagnóstico histológico se hizo por el hallazgo de granulomas no necrotizantes, infiltrado linfocitario y la presencia de células gigantes, sin que se aislara ningún germen. Catorce pacientes recibieron tratamiento sintomático y observación y solo uno presentó afección pulmonar y sintomatología respiratoria y recibió esteroides. El paciente con enfermedad pulmonar sintomática continúa con esteroides y los pacientes observados, por un promedio de 7 años, evolucionaron a resolución espontánea sin producirse recidivas.Sarcoidosis is an infrequent disease in Costa Rica. In 1988 the Hospital San Juan de Dios reported six cases. This is a clinical study of 15 patients diagnosed at the Hospital Calderón Guardia from 1987 to 2001. All the patients presented with thoracic disease and in 12 of them it was localized to the mediastinal lymph nodes. A chest X-ray detected all the cases; cough and dispnea were the most frequent symptoms and mediastinoscopy was the most useful method to obtain a biopsy. The histologic diagnosis was made in the presence of non-necrotizing granulomas, giant cells and a lymphocytic infiltrate. No microorganisms were isolated. Fourteen patients received symptomatic treatment and observation, and one with pulmonary disease and respiratory symptoms received also steroids. All the patients

  1. Carcinoma de seno maxilar en paciente con liquen plano oral: presentación de un caso clínico

    Directory of Open Access Journals (Sweden)

    L.J. Grando

    2013-08-01

    Full Text Available Mujer de 55 años de edad, fumadora, depresiva, con Liquen Plano Oral (LPO de control clínico difícil, de más de 10 años de evolución. La paciente ha presentado períodos de remisión y exacerbación de las lesiones, de forma paralela presentó aumento de volumen intraoral en región maxilar izquierda, la superficie de la nueva lesión estaba ulcerada, y desprendía olor fétido en región alveolar sometida a exodoncias previas. El diagnóstico clínico inicial fue de una probable transformación maligna del LPO preexistente. Una biopsia incisional confirmó la presencia de carcinoma de células escamosas. Los exámenes tomográficos revelaron una amplia imagen destructiva dentro del seno maxilar, con zonas de erosión ósea en las estructuras adyacentes. Con la asociación de datos clínicos y de imagen llegamos al diagnóstico de carcinoma de células escamosas en seno maxilar. La paciente fue sometida a maxilectomía parcial y radioterapia adyuvante. Después de algunos meses, se manifestó la recidiva local con el agravamiento del cuadro clínico del paciente. Se instauró la quimioterapia paliativa adyuvante, sin éxito clínico. La paciente murió después de un año de tratamiento, debido a trombosis.

  2. Relación histopatológica de la displasia epitelial con la oncoproteína p53 en la leucoplasia bucal

    Directory of Open Access Journals (Sweden)

    Zenia Batista Castro

    2012-03-01

    Full Text Available La leucoplasia bucal es una lesión precancerosa bien conocida debido a su asociación con la presencia de displasia epitelial y su tendencia a la transformación maligna. Con el fin de eliminar la subjetividad en la determinación de los grados de la displasia epitelial se han utilizado marcadores biológicos, entre ellos, el AcM anti p53. Por ello se propuso evaluar la expresión del AcM anti p53 en los diferentes grados de displasia epitelial en la leucoplasia bucal. Se emplearon las biopsias de 46 pacientes con diagnóstico de leucoplasia bucal, procedentes del Departamento de Patología Bucal de la Facultad de Estomatología de La Habana. Las muestras fueron procesadas por la técnica de inclusión en parafina y coloreadas con la técnica inmunohistoquímica del complejo avidina-biotina-peroxidasa para el AcM p53. Se estudió la correlación entre el patrón de inmunoensayo para p53 y el grado de displasia epitelial. Se evidenció que existe una asociación significativa entre la inmunocoloración de las células basales y suprabasales del epitelio con la oncoproteína p53, en los distintos grados de severidad de la displasia epitelial, lo que pudiera estar relacionado con el incremento progresivo de atipia celular observada. Se concluyó que en las muestras estudiadas existió una relación coincidente del aumento del grado de severidad de la displasia epitelial, con el marcaje de la oncoproteína p53. Estas evidencias sugirieron que el análisis inmunohistoquímico de p53 en conjunto con los parámetros histológicos, principalmente relacionados con el grado de severidad de la displasia epitelial, pudiera ser utilizado para lograr un diagnóstico más certero y contribuir a la prevención del cáncer bucal.

  3. The diagnostic ability of an additional midline peripheral zone biopsy in transrectal ultrasonography-guided 12-core prostate biopsy to detect midline prostate cancer

    Directory of Open Access Journals (Sweden)

    Inpyeong Hwang

    2016-01-01

    Full Text Available Purpose: The goal of this study was to evaluate the diagnostic effect of adding a midline peripheral zone (PZ biopsy to the 12-core biopsy protocol used to diagnose prostate cancer (PC, and to assess the clinical and pathologic characteristics of midline-positive PC in order to identify a potential subgroup of patients who would require midline PZ biopsy. Methods: This study included 741 consecutive patients who underwent a transrectal ultrasonography-guided, 12-core prostate biopsy with an additional midline core biopsy between October 2012 and December 2013. We grouped patients by the presence or absence of PC and subdivided patients with PC based on the involvement of the midline core. The clinical characteristics of these groups were compared, including serum prostate-specific antigen (PSA concentrations, PSA density, and pathological features in the biopsy specimens. Results: PC was detected in 289 patients (39.0%. Among the PC patients, 66 patients (22.8% had midline PC. No patients were diagnosed with PC based only on a midline core. The Gleason scores, number of positive cores, tumor core length, serum PSA concentrations, and PSA density were significantly higher in patients with midline-positive PC (P<0.001. Furthermore, significant cancer was more frequent in the midline-positive group (98.5% vs. 78.0%. Conclusion: Patients showing a positive result for PC in a midline PZ biopsy were more likely to have multiple tumors or large-volume PC with a high tumor burden. However, our data indicated that an additional midline core biopsy is unlikely to be helpful in detecting occult midline PC.

  4. Listening to music during transrectal ultrasound-guided prostate biopsy decreases anxiety, pain and dissatisfaction in patients: a pilot randomized controlled trial.

    Science.gov (United States)

    Chang, Yun Hee; Oh, Tae Hoon; Lee, Jae Whan; Park, Seung Chol; Seo, Ill Young; Jeong, Hee Jong; Kwon, Whi-An

    2015-01-01

    To determine whether listening to music during transrectal ultrasound (TRUS)-guided 12-core needle prostate biopsy decreases anxiety, pain and dissatisfaction among patients and results in a more comfortable and better tolerated procedure. 76 male patients who underwent TRUS-guided prostate biopsy between March 2013 and June 2014 were randomized into the following groups: no music (group I, n = 38) or classical music (group II, n = 38) during the procedure. Before TRUS-guided prostate biopsy, lidocaine gel was instilled into the rectum. Patient anxiety levels were quantified using the State-Trait Anxiety Inventory. A visual analog scale (0-10) was used for self-assessment of satisfaction, discomfort and willingness among patients to have a repeat TRUS-guided prostate biopsy. Demographic characteristics, mean age, procedure duration and procedure indications did not differ statistically between the two groups. The mean anxiety level and mean pain score of group II were significantly lower than those of group I (p = 0.001 and p = 0.003, respectively). Group II also had a significantly higher mean satisfaction score than group I (p = 0.007). Before the procedure, heart rate and systolic blood pressure were similar in groups I and II; however, after the procedure, levels were lower in group II than in group I (heart rate, p = 0.014; systolic blood pressure, p = 0.011). Listening to music during TRUS-guided prostate biopsy significantly reduced patients' feelings of pain, discomfort and dissatisfaction. Music can serve as a simple, inexpensive and effective adjunct to sedation during TRUS-guided prostate biopsy. We recommend playing music during TRUS-guided prostate biopsy. 2014 S. Karger AG, Basel

  5. Single-dose versus multiple-dose ciprofloxacin plus metronidazole prophylaxis in transrectal ultrasound-guided biopsy of the prostate: a randomized controlled trial.

    Directory of Open Access Journals (Sweden)

    Zhoobin Heidari Bateni

    2014-09-01

    Full Text Available To investigate and compare the infectious and non-infectious complications of single-dose versus multiple-dose antibiotic therapy for trans-rectal ultrasound (TRUS-guided biopsy of the prostate. Patients were enrolled in a prospective randomized study that was designed to investigate the effects of single-dose versus multiple-dose antimicrobial prophylaxis regimen mainly on asymptomatic bacteriuria, urinary tract infection (UTI without fever, fever and urinary septicemia. The single-dose group received one ciprofloxacin 500 mg tablet and two metronidazole 250 mg tablets at 2 hours before the biopsy, while the multiple-doses group received those every 12 hours from 3 days before the biopsy. One-hundred and sixty patients were evaluated in two groups and bacteriuria in urinalysis was encountered in 12 patients (15% in the single-dose group and four patients (5% in the multiple-dose group, with a significant difference (P=0.035. UTI without fever occurred in six patients (7.5% in the single-dose group and one patient (1.25% in the multiple-dose group, with no significant difference (borderline P=0.053. After biopsy, three patients (3.75% returned with fever due to UTI and bacteremia in the single-dose group and none in the multiple-dose group, but with no significant difference (P=0.08. Regarding non-infectious complications, there were no significant differences between the two groups. Using prophylactic antibiotics for prostate biopsy in multiple doses, and at least 3 days before the procedure significantly reduces the rate of bacteriuria compared with a single-dose regimen.

  6. Contrast-enhanced transrectal ultrasound for assessing vascularization of hypoechoic BPH nodules in the transition and peripheral zones: comparison with pathological examination.

    Science.gov (United States)

    Yang, Jing Chun; Tang, Jie; Li, Yanmi; Fei, Xiang; Shi, Huaiyin

    2008-11-01

    The purpose of this study was to investigate the vascularization of zonal location of hypoechoic benign prostatic hyperplasia (BPH) nodules and to evaluate the clinical value of contrast-enhanced transrectal ultrasound (CETRUS) for assessing vascularity of hypoechoic BPH nodules. Sixty-two patients with hypoechoic biopsy-proven BPH nodules in transition zone (TZ) (32 patients) or peripheral zone (PZ) (30 patients) of the prostate gland underwent CETRUS examination between January 2006 and September 2006. The enhancement characteristics of hypoechoic BPH nodules were observed and time to enhancement (AT), time to peak intensity (TTP) and peak intensity (PI) were measured with ACQ time-intensity curve analysis software. In addition, microvessel density (MVD) and vascular endothelial growth factor (VEGF) immunoreactivity were determined in the biopsy specimens. Microvessels were identified by immunohistochemical staining of endothelial cells for CD34. Findings were compared between hypoechoic BPH nodules located in PZ and TZ. The most common enhancement characteristic of hypoechoic BPH nodules in PZ was nonenhanced area inside (21/30), while most of hypoechoic BPH nodules in TZ appeared homogeneous enhancement (28/32). The average AT and TTP were significantly longer, the average PI was significantly lower in hypoechoic BPH nodules located in PZ than TZ (p BPH nodules located in TZ than PZ (p BPH nodules. Hypoechoic BPH nodules located in PZ and TZ showed significant difference in vascularization, which indirectly verified our finding that BPH nodule could occur in the peripheral zone. CETRUS could afford information on the vascularity of hypoechoic BPH nodules in a noninvasive manner and this could be used to improve selection of nodules for biopsy.

  7. The diagnostic ability of an additional midline peripheral zone biopsy in transrectal ultrasonography-guided 12-core prostate biopsy to detect midline prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, In Pyeong; Kim, Sang Youn; Cho, Jeong Yeon; Lee, Myoung Seok; Kim, Seung Hyup [Dept. of Radiology, Seoul National University Hospital and Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul (Korea, Republic of)

    2016-01-15

    The goal of this study was to evaluate the diagnostic effect of adding a midline peripheral zone (PZ) biopsy to the 12-core biopsy protocol used to diagnose prostate cancer (PC), and to assess the clinical and pathologic characteristics of midline-positive PC in order to identify a potential subgroup of patients who would require midline PZ biopsy. This study included 741 consecutive patients who underwent a transrectal ultrasonography-guided, 12-core prostate biopsy with an additional midline core biopsy between October 2012 and December 2013. We grouped patients by the presence or absence of PC and subdivided patients with PC based on the involvement of the midline core. The clinical characteristics of these groups were compared, including serum prostate-specific antigen (PSA) concentrations, PSA density, and pathological features in the biopsy specimens. PC was detected in 289 patients (39.0%). Among the PC patients, 66 patients (22.8%) had midline PC. No patients were diagnosed with PC based only on a midline core. The Gleason scores, number of positive cores, tumor core length, serum PSA concentrations, and PSA density were significantly higher in patients with midline-positive PC (P<0.001). Furthermore, significant cancer was more frequent in the midline-positive group (98.5% vs. 78.0%). Patients showing a positive result for PC in a midline PZ biopsy were more likely to have multiple tumors or large-volume PC with a high tumor burden. However, our data indicated that an additional midline core biopsy is unlikely to be helpful in detecting occult midline PC.

  8. Escherichia coli isolates from patients with bacteremic urinary tract infection are genetically distinct from those derived from sepsis following prostate transrectal biopsy.

    Science.gov (United States)

    Dan, Michael; Yair, Yael; Samosav, Alex; Gottesman, Tamar; Yossepowitch, Orit; Harari-Schwartz, Orna; Tsivian, Alexander; Schreiber, Rachel; Gophna, Uri

    2015-01-01

    Transrectal ultrasound-guided (TRUS) prostate biopsy is a very common procedure that is generally considered relatively safe. However, severe sepsis can occur after TRUS prostate biopsies, with Escherichia coli being the predominant causative agent. A common perception is that the bacteria that cause post-TRUS prostate biopsy infections originate in the urinary tract, but this view has not been adequately tested. Yet other authors believe on the basis of indirect evidence that the pathogens are introduced into the bloodstream by the biopsy needle after passage through the rectal mucosa. We compared E. coli isolates from male patients with bacteremic urinary tract infection (B-UTI) to isolates of patients with post prostate biopsy sepsis (PPBS), in terms of their sequence types, determined by multi-locus sequence typing (MLST) and their virulence markers. B-UTI isolates were much richer in virulence genes than were PPBS isolates, supporting the hypothesis that E. coli causing PPBS derive directly from the rectum. Sequence type 131 (ST131) strains and related strain from the ST131 were common (>30%) among the E. coli isolates from PPBS patients as well as from B-UTI patients and all these strains expressed extended spectrum beta-lactamases. Our finding supports the hypothesis that E. coli causing PPBS derive directly from the rectum, bypassing the urinary tract, and therefore do not require many of the virulence capabilities necessary for an E. coli strain that must persist in the urinary tract. In light of the increasing prevalence of highly resistant E. coli strains, a new approach for prevention of PPBS is urgently required. Copyright © 2015. Published by Elsevier GmbH.

  9. Ultrasound guided transrectal prostate biopsy:11-year experience%B超引导下经直肠前列腺穿刺临床分析

    Institute of Scientific and Technical Information of China (English)

    朱刚; 芦志华; 马宏; 闫伟; 万奔; 王建业

    2009-01-01

    Objective To summarize the experience in ultrasound guided transrectal prostate biopsy and analyze the influeneing factors of the biopsy results.Methods 687 patients with prostate specific antigen(PSA)>4μg,tubemles in prostate detected by digital rectal examination and/or prostate abnormality detected by magnetic resonance imaging,aged(70±8),underwent ultrasound guided transrectal 6-12 core prostate biopsy 1996-2007.Since 2006 the criteria for biopsy ineluded PSA of 4-10μg/ml,free PSA/total PSA ratio(F/T ratio)≤0.16,and PSA density>0.15.Results 269 of the 687 cases.witll the mean age of(72±8),were diagnosed as wlth pmstate cancer.294 and 121 of the 687patients(42.8%and 17.6%respectively)accepted prostate biopsy beeanse of elevated PSA or abnormality of DRE.The number of patients accepting prostate biopsy increased yearly(10 cases in 1996 to 98 cases in 2007).The positive biopsy rate was 39.8%.with the highest rate of 60.0%in 1999 and lowest rate of 30.4%in 2005.The highest number of prostate cancer diagnosed was the highest(42 cases)in 2007 and the lowest(4 cases)in 1996.PSA level was positively co-related with positive biopsy rate.The application of F/T ratio improved the positive biopsy rate in the patient with the PSA of 4-10μg/ml.The incidence rates of the main complications hematuria,bloody stool,and fever were 46.3%,8.7%,and 1.9%respectively.Conclusion Elevated PSA has become the most common resson for prostate biopsy.The combination with PSA.F/T ratio.and increased biopsy core number improve the positive biopsy rate.The ultrasound guided transrectal prostate biopsy is efficient and safe in the diagnosis of prostate cancer.%目的 总结B超引导下经直肠前列腺穿刺的经验并分析影响前列腺穿刺结果的因素.方法 统计卫生部北京医院1996-2007年行B超引导下经直肠前列腺穿刺病例.患者入选条件为前列腺特异抗原(PSA)>4μg/L,和(或)直肠指检发现前列腺结节,和(或)B超或磁共振成像(MRI)检

  10. Entrevista con Alberto Tenenti.

    Directory of Open Access Journals (Sweden)

    - Consejo de Redacción

    1995-01-01

    Full Text Available Gran especialista en historia moderna, Alberto Tenenti nació en Viareggio, en 1924. Tras realizar estudios superiores en Italia, trabajó en el Centre National de la Recherche Scientifique varios años, asesorado por Lucien Febvre. Ha dirigido el Archivo del Estado de Brescia; y, más tarde, ha enseñado en París, desde una cátedra en la École Pratique des Hautes Études en Sciences Sociales (VI Sección, alIado de Braudel. Su Il senso della morte e l'amore della vita nel Rinascimento, de 1957, es una obra maestra sobre los orígenes de la sensibilidad moderna: sin olvidar el naciente vitalismo, estudia el desarrollo de dos motivos, el del ars moriendi, que tiene su evolución propia desde 1350 hasta su difusión impresa, y el de lo macabro, que refleja la crisis de conciencia del siglo XV y adquiere «unas dimensiones desconocidas y verdaderamente anormales». En este libro sobre un problema clave como la muerte, apela de modo notable a la iconografía: Tenenti ha recordado que la cultura tradicional, eclesiástica sobre todo, percibió un mayor peligro en la capacidad de reflexión autónoma y de crítica de los hombres de letras, que en las renovaciones radicales de los artistas. Numerosos trabajos de conjunto realizados por él han perseguido una historia global: Los fundamentos del mundo moderno; Florencia en la época de los Medicis; La formación del mundo moderno; El Renacimiento; el primero de ellos estaba firmado con un historiador de su misma generación, R. Romano, estudioso de las relaciones comerciales en la época moderna en Europa y en la América española. Tenenti ha publicado monografías (Venezia e i corsari, 1961, colecciones de artículos (Credence, ideologie, libertinismi tra medioevo ed eta moderna, 1978; Stato: un'idea, una logica. Dal comune italiano all'assolutismo francese, 1987 y editado a clásicos como Il libri della famiglia de L. B. Alberti, 1969. Es también especialista en temas económicos, como el del

  11. Puentes con vigas pretensadas

    Directory of Open Access Journals (Sweden)

    Editorial, Equipo

    1965-07-01

    Full Text Available This paper describes one of the three bridges which Hidrocivil, S. A., has built in Catalonia (northern Spain, over the river Ripoll. The other two bridges are very similar to this one, both in construction and design, and show only minor adjustments to the local topography. The contracting firm proposed several alterations in the prefabrication and constructional procedure, in relation to the initial project, and these changes were accepted. The main feature of these projects is the use of prestressed beams, built at the workshop in sections, and joined together by means of sixty 7 mm cables in each beam. As the shear forces are more acute at the joints, the end of each section has a kind of diaphragm, to provide a large contact area, and hence greater surface to transmit the shear forces. The methods of construction are also of interest. Briefly, they involve building the bridge piles, and use these to support a provisional structure with transversal movement. This provisional structure, in turn, served as platform for two bridge cranes, which lifted the girders to their final location. After the first span was completed, the deck was concreted and the auxiliary structure pushed forward to the next span, to repeat the same operations. This arrangement saved the use of provisional framework.En este trabajo se describe uno de los tres puentes que Hidrocivil, S. A., ha construido.—previo concurso— en la región catalana; concretamente, el que salva el río Ripoll. Los otros dos no han sido objeto de descripción general por ser muy similares, en lo que a ejecución y concepción se refiere, con la única variante que presentan las características topográficas locales. La empresa propuso ciertas variantes— que fueron aceptadas— en la prefabricación y métodos de construcción. El interés de estas obras se centra en el empleo de vigas pretensadas, prefabricadas en taller por trozos, y solidarizados en el mismo mediante las operaciones

  12. Violencia con el anciano

    Directory of Open Access Journals (Sweden)

    Rita Campillo Motilva

    2002-08-01

    Full Text Available La violencia doméstica es tan antigua como la humanidad misma y se reconocen la violencia infantil, contra la mujer y al anciano, fundamentalmente; siendo este último grupo una población en ascenso por las mayores expectativas de vida de los últimos años. Como resultado de ello, el número de casos de abuso en el anciano se incrementará y el impacto de este abuso sobre la salud debe ser considerado de forma adecuada. La gama de maltratos es variadísima e incluye el abuso físico, emocional, financiero, sexual, por negligencia, negación a brindarle ayuda y otras formas más. Los ancianos con deterioro cognitivo son los más vulnerables. El médico en la atención primaria de salud es un pilar importante en la prevención y educación de este problema.Domestic violence is as old as humanity itself. Child, women and elderly abuse are mainly recognized. The elderly group is increasing due to the higher life expectancy experimented during the last years. As a result, the number of battered elderly will grow and the impact of this abuse on health should be adequately considered. The range of abuse is very wide and it includes physical, emotional, financial and sexual abuse, negligence, rejection to give assistance and others. The elderly with cognitive deterioration are the most vulnerable. The physician at the primary health care level is an important milestone in the prevention and education of this problem.

  13. Entrevista con Bernard Vincent.

    Directory of Open Access Journals (Sweden)

    Fernando Colina Pérez

    2006-01-01

    Full Text Available Nacido en París (1941, Bernard Vincent es un historiador de renombre en Europa y América del Sur. Consiguió su agregación universitaria en 1966, y desde sus inicios se centró en la Historia Moderna, particularmente en grupos marginales de la España de los siglos XVI-XVII. Ha residido en nuestro país muchos años. Vincent fue miembro de la sección científica de la Casa de Velázquez inicialmente (1968-1971, algo más tarde director de estudios (1977-1978, y a continuación secretario general (1978-1982 de dicha institución. Asimismo ha encabezado el programa de cooperación francoespañol en ciencias sociales (1993-1996. Por otra parte, ha enseñado en la Universidad de París VII, en varias etapas de su vida; pero, sobre todo, ha pertenecido siempre a centros superiores de investigación: Centre National de la Recherche Scientifique (1976-1978, y a la École des Hautes Études en Sciences Sociales, en donde ha sido director de estudios desde 1988 –era doctor de Estado ya en 1986–, y luego responsable de la Sección de Historia, desde 1996 hasta hoy. Sus colaboraciones con las universidades y centros investigadores españoles han sido constantes hasta el presente. Por añadidura, ha sido miembro del Consejo Nacional de las Universidades en Francia, en lo relativo a la historia moderna y contemporánea (1987-1988, 1992-1995, y es desde hace años miembro de la madrileña Academia de la Historia.

  14. Matrices con entradas enteras e inversa con entradas enteras

    OpenAIRE

    Mora, Walter

    2004-01-01

    Algunos artículos publicados en The American Mathematical Monthly discuten acerca de la construcción de matrices con entradas enteras, valores propios enteros y vectores propios con componentes enteras, en particular en [1] se hace una construcción que además permite construir, de manera sencilla, matrices con entradas enteras cuya inversa también tiene entradas enteras. Este artículo trata de estas últimas construcciones e incluye software en Java para generar y modificar ejemplos y para hac...

  15. Matrices con entradas enteras e inversa con entradas enteras

    OpenAIRE

    Mora, Walter

    2004-01-01

    Algunos artículos publicados en The American Mathematical Monthly discuten acerca de la construcción de matrices con entradas enteras, valores propios enteros y vectores propios con componentes enteras, en particular en [1] se hace una construcción que además permite construir, de manera sencilla, matrices con entradas enteras cuya inversa también tiene entradas enteras. Este artículo trata de estas últimas construcciones e incluye software en Java para generar y modificar ejemplos y para hac...

  16. con el aborto provocado

    Directory of Open Access Journals (Sweden)

    José Luis Redondo Calderón

    2008-01-01

    Full Text Available Las vacunas de células diploides humanas (WI-38, MRC-5 tienen un origen éticamente objetable, dado que dichas células proceden de abortos provocados. Entre ellas destacan vacunas empleadas contra rubéola, sarampión, parotiditis, rabia, poliomielitis, viruela, hepatitis A, varicela y herpes zóster. Actualmente se encuentran en desarrollo otras vacunas cultivadas en células (293, PER.C6 transformadas mediante virus, procedentes de abortos. Entre ellas hay vacunas contra la gripe, virus respiratorio sincitial, parainfl uenza, HIV, virus del Nilo Occidental, virus Ébola, Marburg y Lassa, hepatitis B y C, glosopeda, encefalitis japonesa, dengue, tuberculosis, carbunco, peste, tétanos y paludismo. También con igual origen se trabaja en la elaboración de anticuerpos monoclonales y otras proteínas, terapia génica y genómica. Existe la tecnología necesaria para producir todo lo descrito sin recurrir a abortos provocados. Debe indicarse en los prospectos de vacunas y otros productos el origen de las células empleadas. Debe facilitarse el acceso a las vacunas existentes no cultivadas en células procedentes de abortos provocados. Debe potenciarse la investigación de opciones en aquellos casos en los que no exista una vacuna no originada en células procedentes de abortos provocados. Debe potenciarse la elaboración de anticuerpos monoclonales y de otras proteínas, así como la terapia génica y la genómica sin recurrir a células procedentes de abortos provocados. No sería consecuente rechazar productos obtenidos a partir de células troncales embrionarias y aceptar los originados en células procedentes de abortos provocados. Se debe evitar que la biotecnología basada en el aborto provocado invada todos los terrenos de la medicina.

  17. Perfil del trabajador con discapacidad

    OpenAIRE

    CAPGEMINI; FUNDACIÓN ADECCO

    2014-01-01

    Capgemini y la Fundación Adeco analizan y reflexionan sobre empleo de las personas con discapacidad. A pesar de los avances que se están registrando en este ámbito, la situación laboral de las personas con discapacidad aún está lejos de alcanzar las cotas deseadas de normalización: mientras que la tasa de actividad de las personas sin discapacidad se sitúa en el 76,3%, la de las que sí la tienen desciende bruscamente hasta el 36,5%. En otras palabras, un 63,4% de las personas con discapacidad...

  18. Valoracion de la calidad del injerto hepático mediante la determinación de los patrones metabonómicos en biopsia del hígado donante

    OpenAIRE

    Cortes Cerisuelo, Miriam

    2015-01-01

    El trasplante de hígado (TH) constituye en el tratamiento de elección para las enfermedades hepáticas en estadio terminal, sin embargo, el desequilibrio entre el número de donantes y pacientes en lista de espera ha conducido a la utilización de injertos procedentes de donantes con criterios extendidos. Esta práctica, se ha traducido en una reducción de la tasa de mortalidad entre los pacientes en lista de espera, a expensas de un aumento de las complicaciones post-trasplante, como la disfunci...

  19. New kidney immobilization method for percutaneous renal biopsy technique in cats: Operational aspects and complications Novo método de imobilização do rim para biopsia renal percutânea em gatos: Aspectos operacionais e complicações

    Directory of Open Access Journals (Sweden)

    Daniele Alves Silva

    2012-01-01

    Full Text Available PURPOSE: Evaluate a new immobilization kidney method for collecting blind percutaneous renal biopsies (RB in healthy cats. METHODS: Ten cats were biopsied by a modified blinded percutaneous technique using semi-automated needles. Were evaluated the operational aspects of the technique, its complications, and the quality of the obtained samples. The evaluation included physical examination, hemogram, urinalysis, abdominal ultrasound, renal function, and histopathology of the biopsy specimens. RESULTS: The developed technique was fast and easy to perform; it required two operators, and the right kidney was elected for specimen collection. After the RB, a decrease in hematocrit levels was observed in addition to hematuria and perirenal transient hematoma; however, no clinical consequences were observed, and normal parameters were restored within 48 hrs. There were no major complications or deaths, alterations in the physical examination or renal function, or signs of infection. Of the samples, 95% revealed the presence of renal tissue, and in 100% of the cats the samples were of diagnostic quality. CONCLUSION: The technique was easily performed, provided adequate material for diagnosis with minimal transient complications.OBJETIVO: Avaliar um novo método de imobilização do rim para coleta de biopsia renal (BR percutânea às cegas em gatos hígidos. MÉTODOS: Dez gatos foram biopsiados por uma técnica de biopsia percutânea às cegas modificada, com uso de agulha semi-automática. Foram avaliados os aspectos operacionais da técnica, complicações e a qualidade das amostras obtidas. A avaliação incluiu exame físico, hemograma, urinálise, ultrassonografia abdominal, função renal e análise histopatológica do espécime de biopsia. RESULTADOS: A técnica foi de fácil realização; foram requeridos dois operadores, e o rim direito foi eleito para a coleta da BR. Após a BR, diminuição do hematócrito foi observada, em conjunto com hemat

  20. Varicela sobreinfectada con Staphylococcus Aureus

    Directory of Open Access Journals (Sweden)

    Fabiana A. Bellot

    2010-12-01

    Full Text Available Paciente masculino de 5 años de edad internado por presentar un cuadro clínico de más o menos cuatro días de evolución caracterizado por la presencia de fiebre, malestar general, anorexia y dolor abdominal leve complicándose con la aparición de erupciones en piel, cuero cabelludo, cara, tronco y mucosas de características maculo-papulosas eritematosas con un halo eritematoso. Las mismas de tamaños y formas variables, tensas, con contenido purulento, acompañado de fiebre de 38 C°. Al examen físico se evidencian: lesiones dérmicas sobreinfectadas con secreción purulenta en algunas regiones del cuerpo (rostro y tronco. El diagnóstico de ingreso fue varicela sobreinfectada por estafilococo.

  1. A patadas con los botes

    OpenAIRE

    Lorenzo, José

    1994-01-01

    Presentamos a continuación una actividad desarrollada con alumnos de 4° de Enseñanza Secundaria Obligatoria, en la materia optativa: taller de resolución de problemas. Auna el enfrentamiento a una actividad real. cotidiana, con la utilización de procedimientos y conceptos fundamentales en la formación básica en matemáticas.

  2. Impact of preoperative screening for rectal colonization with fluoroquinolone-resistant enteric bacteria on the incidence of sepsis following transrectal ultrasound guided prostate biopsy

    Directory of Open Access Journals (Sweden)

    Farrell JJ

    2017-02-01

    for rectal colonization with fluoroquinolone-resistant bacteria prior to transrectal prostate biopsy. The observed risk reduction in the rectal screening group trended toward, but did not achieve, statistical significance. We suggest that preoperative screening for rectal colonization with fluoroquinolone-resistant enteric bacteria may be a useful step toward mitigating post-prostate biopsy sepsis. Keywords: sepsis, gram-negative infections, antimicrobial stewardship, preoperative antibiotic prophylactic treatment 

  3. Multiparametric Magnetic Resonance Imaging (MRI) and MRI-Transrectal Ultrasound Fusion Biopsy for Index Tumor Detection: Correlation with Radical Prostatectomy Specimen.

    Science.gov (United States)

    Radtke, Jan P; Schwab, Constantin; Wolf, Maya B; Freitag, Martin T; Alt, Celine D; Kesch, Claudia; Popeneciu, Ionel V; Huettenbrink, Clemens; Gasch, Claudia; Klein, Tilman; Bonekamp, David; Duensing, Stefan; Roth, Wilfried; Schueler, Svenja; Stock, Christian; Schlemmer, Heinz-Peter; Roethke, Matthias; Hohenfellner, Markus; Hadaschik, Boris A

    2016-11-01

    Multiparametric magnetic resonance imaging (mpMRI) and MRI fusion targeted biopsy (FTB) detect significant prostate cancer (sPCa) more accurately than conventional biopsies alone. To evaluate the detection accuracy of mpMRI and FTB on radical prostatectomy (RP) specimen. From a cohort of 755 men who underwent transperineal MRI and transrectal ultrasound fusion biopsy under general anesthesia between 2012 and 2014, we retrospectively analyzed 120 consecutive patients who had subsequent RP. All received saturation biopsy (SB) in addition to FTB of lesions with Prostate Imaging Reporting and Data System (PI-RADS) score ≥2. The index lesion was defined as the lesion with extraprostatic extension, the highest Gleason score (GS), or the largest tumor volume (TV) if GS were the same, in order of priority. GS 3+3 and TV ≥1.3ml or GS ≥3+4 and TV ≥0.55ml were considered sPCa. We assessed the detection accuracy by mpMRI and different biopsy approaches and analyzed lesion agreement between mpMRI and RP specimen. Overall, 120 index and 71 nonindex lesions were detected. Overall, 107 (89%) index and 51 (72%) nonindex lesions harbored sPCa. MpMRI detected 110 of 120 (92%) index lesions, FTB (two cores per lesion) alone diagnosed 96 of 120 (80%) index lesions, and SB alone diagnosed 110 of 120 (92%) index lesions. Combined SB and FTB detected 115 of 120 (96%) index foci. FTB performed significantly less accurately compared with mpMRI (p=0.02) and the combination for index lesion detection (p=0.002). Combined FTB and SB detected 97% of all sPCa lesions and was superior to mpMRI (85%), FTB (79%), and SB (88%) alone (pcorrelation coefficient for index lesion agreement between mpMRI and RP was 0.87 (p<0.001). Limitations included the retrospective design, multiple operators, and nonblinding of radiologists. MpMRI identified 92% of index lesions compared with RP histopathology. The combination of FTB and SB was superior to both approaches alone, reliably detecting 97% of s

  4. A randomised controlled trial comparing use of lignocaine periprostatic nerve block alone and combined with diclofenac suppository for patients undergoing transrectal ultrasound (TRUS)-guided prostate biopsy.

    Science.gov (United States)

    Ooi, Wei Ling; Hawks, Cynthia; Tan, Andrew H H; Hayne, Dickon

    2014-11-01

    To examine whether or not the combination of diclofenac suppository with peri-prostatic nerve block (PPNB) was effective in reducing the degree of pain experienced during transrectal ultrasound (TRUS)-guided prostate biopsy in a randomised single-blind placebo-controlled trial. In all, 96 patients having a planned TRUS-guided prostate biopsy were randomised into one of the following arms on a 1:1 basis: 10 mL 1% lignocaine PPNB and placebo suppository (control) or 10 mL 1% lignocaine PPNB and 100 mg diclofenac suppository (treatment). Pain scores were recorded using the Numerical Rating Scale for pain (0-10) at the following time-points: (i) introduction of probe, (ii) during biopsy, (iii) 1 h after biopsy, (iv) later that evening (≈6 h after biopsy) and (v) 1 day after biopsy. Patients were asked about their preferred method for pain control if a repeat TRUS-guided prostate biopsy was required: local anaesthetic (LA) again or intravenous sedation. There were no significant differences in age (P = 0.653) or PSA level (P = 0.584) between either study arm. The differences in pain scores between the control and treatment groups were not significant at Time 1 (probe insertion; P = 0.299), Time 2 (biopsy; P = 0.983), Time 4 (evening after; P = 0.231) and Time 5 (1 day after biopsy; P = 0.384). At Time 3 (1 h after biopsy), the control pain scale scores were statistically significantly higher than the treatment pain scale scores (P = 0.044). There was no difference between treatment (87%) and control (80%) groups as to whether they would prefer to repeat the biopsy under LA (P = 0.373). The use of a diclofenac suppository with PPNB did not show any clinically meaningful effect in decreasing pain or improving tolerability of TRUS-guided prostate biopsy and is not recommended. PPNB TRUS-guided biopsy is extremely well tolerated, with >80% of patients electing for subsequent LA biopsy if required. © 2014 The Authors. BJU International © 2014 BJU

  5. con mala calidad de vida

    Directory of Open Access Journals (Sweden)

    Agustín Martín-Rodríguez

    2007-01-01

    Full Text Available En este estudio ex post facto se ha analizado si los familiares de pacientes con mala calidad de vida presentan diferencias en las variables clínicas de personalidad y relaciones familiares en función de que el paciente haya estado o no ingresado en una Unidad de Cuidados Intensivos. Seleccionamos dos grupos: 29 familiares de pacientes traumatizados graves transcurridos cuatro años de su ingreso en una UCI de Traumatología y con mala calidad de vida (debido a secuelas físicas y/o psicológicas tras el ingreso, tales como traumatismos craneoencefálicos, politraumatismos y tetraplejias traumáticas y 32 familiares de pacientes con mala calidad de vida con cuatro años de evolución de su enfermedad física (hipertensión, diabetes, artritis reumatoide y síndrome de intestino irritable que no han estado ingresados en la UCI. Para alcanzar nuestro objetivo empleamos una Encuesta Psicosocial y los siguientes instrumentos: Cuestionario de Análisis Clínico, Escala de Clima Social en la Familia y Escala de Adaptación Psicosocial de la Enfermedad. Los resultados mostraron que los familiares de pacientes con mala calidad de vida que estuvieron ingresados en la UCI hace cuatro años, presentan diferencias significativas en las variables agitación y expresividad comparados con los familiares de pacientes con mala calidad de vida que no han estado ingresados en la UCI.

  6. Encuentro con el tiempo: Adagio con variaciones de Alfredo Aracil

    Directory of Open Access Journals (Sweden)

    Rosa María Rodríguez Hernández

    2012-01-01

    Full Text Available Examinando analíticamente la obra sinfónica Adagio con variaciones de Aracil, estudiaremos los principales componentes para concluir con una evaluación de los mismos. A través de la cronología de la obra de Aracil175, observamos la importancia que adquiere en su trayectoria la memoria; su pensamiento va siempre unido a ésta. Uno de sus recursos principales es la cita; es Adagio con variaciones donde claramente observaremos la memoria lejana e inmediata al tiempo: Wagner es el punto de referencia al pasado, Wolf impulsa hacia el presente, y, Aracil advierte el devenir en cada una de sus variaciones.

  7. Application value of transrectal ultrasonography with transvaginal probe in diagnosis of polycystic ovary syndrome among unmarried women%阴式探头经直肠超声在诊断未婚女性多囊卵巢综合征中的应用价值

    Institute of Scientific and Technical Information of China (English)

    魏敏; 范丽梅; 翟萍; 王胜文

    2011-01-01

    Objective: To explore the clinical application value of transrectal ultrasonography with transvaginal probe in diagnosis of polycystic ovary syndrome among unmarried women. Methods: The results of 120 unmarried women with polycystic ovary s]drome examined by transabdominal ultrasonography and transrectal ultrasonography were compared. Results: The detection rates of transabdominal ultrasonography and transrectal ultrasonography in diagnosis of polycystic ovary syndrome among unmarried women were 31.14% and 90. 73%,respectively. Conclusion: Transrectal ultrasonography can increase the diagnosis rate of polycystic ovary syndrome among unmarried women,which is worthy to be popularized.%目的:探讨阴式探头经直肠超声检查诊断未婚女性多囊卵巢综合征的临床应用价值.方法:比较经腹部超声与经直肠超声检查未婚女性多囊卵巢综合征的患者120例.结果:经腹部超声诊断未婚女性多囊卵巢综合征,检出率只有31.14%,而经直肠超声检查诊断符合率可达90.73%.结论:经直肠超声可提高未婚女性多囊卵巢综合征的诊断率,值得临床推广使用.

  8. Los nenes con los zombies, las nenas con los vampiros

    OpenAIRE

    López Corral, Manuela

    2012-01-01

    En este artículo nos circunscribiremos, dentro de este género literario, a las sagas de reciente salida editorial y, con mayor precisión, a las sagas de novelas románticas para adolescentes tales como Crepúsculo (Stephenie Meyer, 2005), Hush Hush (Becca Fitzpatrick, 2009), Cazadores de Sombras (Cassandra Clare, 2007), Fallen (Lauren Kate, 2010), y otras similares, dejando de lado sagas con otro tipo de particularidades como los citados libros de Harry Potter o los pertenecientes a la trilogía...

  9. Los nenes con los zombies, las nenas con los vampiros

    OpenAIRE

    López Corral, Manuela

    2012-01-01

    En este artículo nos circunscribiremos, dentro de este género literario, a las sagas de reciente salida editorial y, con mayor precisión, a las sagas de novelas románticas para adolescentes tales como Crepúsculo (Stephenie Meyer, 2005), Hush Hush (Becca Fitzpatrick, 2009), Cazadores de Sombras (Cassandra Clare, 2007), Fallen (Lauren Kate, 2010), y otras similares, dejando de lado sagas con otro tipo de particularidades como los citados libros de Harry Potter o los pertenecientes a la trilogía...

  10. Entrevista con Hans Robert Jauss.

    Directory of Open Access Journals (Sweden)

    - Consejo de Redacción

    1997-01-01

    Full Text Available El importante teórico y crítico literario alemán nació en 1921. Tras el largo paréntesis de la segunda guerra mundial, Jauss realizará sus estudios superiores, a partir de 1948, en Heidelberg, licenciándose en filología románica. Se doctora pronto con una tesis, publicada en 1955, sobre el tiempo y el recuerdo en la obra capital de Marcel Proust, En busca del tiempo perdido, y se habilita en 1957 con un trabajo sobre la epopeya animal en la Edad Media. A continuación, escribe un conjunto de estudios sobre la alegoría, y codirige con el gran especialista Erich Kohler una monumental historia de la literatura medieval, campo al que ha dedicado otros artículos, a la par que proseguía sus investigaciones iniciales.

  11. Tratamiento con implantes Leader-Nano en paciente con oligodoncia

    Directory of Open Access Journals (Sweden)

    Salvador Javier Santos Medina

    2015-03-01

    Full Text Available Los implantes dentales de titanio han revolucionado el mundo de la rehabilitación desde su surgimiento. De manera particular, el empleo de implantes de carga inmediata acorta el tiempo quirúrgico y protésico, con el consiguiente bienestar estético. Se presenta el caso de una paciente femenina de 32 años de edad, con antecedentes de oligodoncia de ambos incisivos laterales superiores y portadora de prótesis parcial acrílica. Fue atendida por el equipo multidisciplinario de implantes en la Clínica Estomatológica Docente “3 de Octubre” y se le realizó tratamiento de rehabilitación integral con implantes Leader-Nano y prótesis fija con corona acrílica sobre dichos implantes. La implantología fue satisfactoria en la paciente; la mejoría estética y funcional, así como la satisfacción de la paciente, fueron los principales logros obtenidos

  12. Huevos enriquecidos con omega 3

    OpenAIRE

    Viteri, Evelyn

    2013-01-01

    El presente trabajo es una contribución al estudio de usos de ingredientes no tradicionales; harina de algas, Macrocystis pyrifera, y la inclusión en raciones para aves de postura destinado a aumentar la concentración de omega 3 del huevo. Objetivo: Evaluar en la alimentación de la gallina la inclusión de harina de alga marina Macrocystis pyrifera con el fin de aumentar el valor de omega 3 en el huevo, y el grado de aceptación de un producto elaborado con el mismo en estudiante...

  13. ARLAB: Laboratorio con Realidad Aumentada

    OpenAIRE

    Rodríguez Calderón, Rosalino; Santillana Arbesú, Rafael

    2013-01-01

    ResumenARLAB es una innovación que incorporar tecnología de realidad aumentada a los experimentos clásicos decontrol y automatización industrial, permitiendo integrar y que interactúen varias tecnologías desarrollándoseexperimentos mixtos, parte real y parte virtual en 3D, que se visualiza con un dispositivo inteligente, como lo esun celular o tableta electrónica; con el fin de generar una visión del conocimiento más profunda y clara.

  14. con dietas suplementadas con Cromo-L-metionina

    Directory of Open Access Journals (Sweden)

    Ram\\u00F3n Garc\\u00EDa-Castillo

    2006-01-01

    Full Text Available Un total de 48 cerdos (Sus scrofa domesticus; 24 machos castrados y 24 hembras cruzados (Yorkshire, Hampshire, Duroc y Landrace de 3,5 a 4,0 meses de edad y 60,0 ± 5,0 kg PV en finalización. Se alimentaron con dietas isoproteícas (14,5 % PC e isoenergéticas (3.400 kcal EM/kg de MS, adicionadas con Cr-L-metionina (MiCroPlex® (0, 200, 400 y 600 ppb. El experimento tuvo una duración de 45 días y se realizó de agosto a noviembre del 2002 en las instalaciones de la Universidad Autónoma Agraria Antonio Narro, localizada en Saltillo, Coahuila, México. Al tener los animales aproximadamente 95 kg PV, se tomó muestra de 15 ml de sangre por cada animal para determinar la concentración de glucosa, ácido úrico, creatinina, urea, proteinas totales y colesterol. Se aplicó un diseño completamente al azar con arreglo factorial 2 x 4; dos para el factor sexo y cuatro para nivel de cromo. Los metabolitos en suero no fueron afectados (P>0,05 por el factor sexo. La glucosa en suero disminuyó (P<0,05 y el colesterol incrementó (P<0,05 con cromo en la dieta. Se concluye que el Cr incrementa el metabolismo de glucosa y disminuye el de colesterol, con lo cual puede haber energía disponible para síntesis de proteína la cual es necesaria para el crecimiento de los animales

  15. Changes of Abdominal Ultrasound and Transrectal Ultrasound Detection of Prostate%腹部超声与直肠腔超声检测前列腺疾病的差异变化

    Institute of Scientific and Technical Information of China (English)

    王硕

    2015-01-01

    目的:探讨腹部超声与直肠腔超声检测前列腺疾病的差异变化。方法选取72例前列腺疾病患者,比较腹部超声和直肠腔内超声检测的差异。结果经腹部超声及直肠腔内超声检测,3组患者的前列腺前后径、左右径均超出正常范围,C组患者前列腺前后径、左右径明显长于A组、B组,差异有统计学意义(P<0.05)。直肠腔内超声诊断前列腺疾病癌、囊肿、增生、钙化的准确率均明显高于腹部超声,差异均有统计学意义(均P<0.05)。结论与腹部超声比较,直肠腔内超声在诊断前列腺疾病方面具有更高的灵敏性和准确性。%Objective To observe the difference of abdominal ultrasound and endorectal ultrasound in detection of prostatic diseases.Methods According to the age characteristics,72 patients with prostate disease in our hospi- talpatients were divided into 3 groups,A group(50~59 years old),B group(60~69 years old),C group(70~79 years old),24 cases in each group,the compared the difference between abdominal ultrasound and endorectal ultrasound. Results The abdominal ultrasound and transrectal ultrasound,3 groups of patients before and after the prostate size,diameter were beyond the normal range,and C group of patients with prostate size,diameter was significantly longer than that in A group,B group,the difference was statisticaly significant(P<0.05).The accuracy of transrectal ultrasound in diagnosis of prostate diseases, cancer, proliferation,calcification of the cyst was significantly higher than that of abdominal ultrasound,the differences were statisticaly significant(P<0.05).Conclusion Compared with transabdominal ultrasound,transrectal ultrasonography has higher sensitivity and accuracy in the diagnosis of prostate disease.

  16. 经直肠彩色多普勒超声对前列腺癌的诊断价值%Value of transrectal color Doppler ultrasound in diagnosis of prostatic carcinoma

    Institute of Scientific and Technical Information of China (English)

    易发现; 李永忠; 李响

    2012-01-01

    Objective To evaluate the clinical value of transrectal color Dopplei ultrasound in diagnosis of prostatic carcinoma. Methods Thiity-one patients with prostatic carcinoma were examined by transrectal color Dopplei ultrasound, and 31 patients with benign hyperplasia were involved as the control group. Then the shape, lesion size, internal echo oi prostate, membranes and whether metastasis in surrounding organs in two groups were observed. Blood flow distribution of prostate and interior and periphery of the lesions were observed with color Doppler flow imaging( CDFI) , the internal diameter, the peak velocity and resistance index of the art ray were measured. Results Prostatic carcinoma was associated with calcification with the form of cluster, weak echoes, increased blood flow, increased resistance index, respectively. Multivariant logistic regression showed increased blood flow and increased resistance index were independent risk factors of prostatic carcinoma( P= 0. 011 ,OR= 17. 3 16 ;P= 0. 007 , OR = 14. 068). Conclusion Transrectal color Doppler ultrasound can improve the diagnostic accurate rate of prostate cancer.%目的 评价经直肠彩色多普勒超声诊断前列腺癌的临床价值.方法 应用经直肠彩色多普勒超声对31例前列腺癌(试验组)进行检查,同时选取31例良性前列腺增生患者为对照组,观察两组前列腺形态、病灶大小及内部回声情况,包膜的完整及周边邻近器官是否有转移灶.然后应用彩色多普勒超声观察前列腺及结节内部、周边血流分布状态、测量血管内径并记录动脉频谱的峰值,计算阻力指数.结果 前列腺癌与簇状钙化、低回声、回声不均、血流信号增强、阻力指数升高等有关,经Logistic回归分析,血流信号增强和阻力指数增高分别是前列腺癌的独立危险因素(P=0.011,OR=17.316;P=0.007,OR=14.068).结论 经直肠彩色多普勒超声能提高前列腺癌的诊断准确率.

  17. Pathologic diagnosis and Gleason grading of prostatic carcinoma by transrectal ultrasound-guided prostate needle biopsy%穿刺活检前列腺癌72例病理形态学观察及Gleason分级

    Institute of Scientific and Technical Information of China (English)

    王云帆; 缪琦; 王淑芳; 饶晓松

    2013-01-01

    目的 观察经直肠超声引导的前列腺癌穿刺活检组织的病理形态学改变,进行系统的Gleason分级.方法 收集经直肠超声引导的前列腺穿刺活检诊断的前列腺癌72例,复习HE组织切片,并依据2005年国际泌尿病理学协会(ISUP)修订的前列腺癌Gleason分级系统进行分级.结果 72例前列腺癌中53例的主要及次要成分为3级结构(73.6%),59例主要及次要成分为4级结构(81.9%),12例主要及次要成分为5级结构(16.7%).结论 本组前列腺癌Gleason 4级结构与3级结构常常混合存在,而且4级结构相比3级结构更为常见.修订后的Gleason分级系统有助于对前列腺癌进行规范分级,以利于进一步研究,准确反映肿瘤的预后差异.%Objective To study the morphological diagnostic criteria and Gleason grading of prostatic carcinoma in transrectal ultrasound guided prostate needle biopsy. Methods 72 cases of prostatic needle biopsy guided by transrectal ultrasound were reviewed. Routine pathological examination was used in the study. Data with respect to Gleason grading were studied according to the refinements of the ISUP 2005 consensus conference on Gleason grading of needle biopsies. Results The results showed that Gleason pattern 3 was seen in 73. 61% ; pattern 4 in 81. 94% ; pattern 5 in 16. 67% among 72 cases of prostatic carcinoma. Conclusions Most of the tumors show at least two different patterns, and the pattern 4 is more common than pattern 3. The use of modified Gleason scoring leads to improves the prognostic value of the patients with prostate cancer and can be more accurately assessed in transrectal ultrasound guided prostate needle biopsy. Continued effort is required to refine biopsy strategies to Gleason grading of prostatic specimens.

  18. Diagnostic Value of Transrectal Ultrasonics in Prostatic Adenocarcinoma and Urethral Invasion%直肠超声对前列腺癌及其侵及尿道的诊断价值

    Institute of Scientific and Technical Information of China (English)

    林礼务; 林晓东; 俞丽云; 叶真; 薛恩生; 何以敉; 高上达

    2001-01-01

    目的提高直肠超声检查对前列腺癌(PCA)及其侵及尿道的诊断水平。方法对42例病理证实的PCA(其中6例侵及尿道)及15例正常前列腺进行经腹壁与直肠超声检查、直肠指诊及血清PSA测定的对比观察。结果直肠超声、直肠指诊、PSA测定与腹部超声对42例PCA患者的诊断阳性率分别为66.7%(28/42)、42.9%(18/42)、81.0%(34/42)与33.3%(14/42)。对PCA侵及尿道的诊断阳性率也分别为83.3%(5/6)、66.7%(4/6)、83.3%(5/6)与33.3%(2/6)。结论直肠超声检查如发现前列腺不对称增大,包膜欠光滑或突向膀胱或前列腺内见低回声结节与杂乱回声区,应高度怀疑PCA并应结合血清PSA测定与直肠指诊等综合判断。%PurposeTo raise the transrectal ultrasonic diagnostic level of the prostatic adenocarcinoma as well as the urethral invasion. MethodsForty-two patients with the prostatic adenocarcinoma and fifteen cases with the normal prostata were respectively examined by the transrectal ultrasonography, the transabdominal ultrasonography and the rectal touch. The serum PSA of each case was also examined. Results The positive rates of the transrectal ultrasonography, the rectal touch., the serum PSA determination and the transabdominal ultrasonography of the prostatic adenocarcinomas of the 42 patients were 66.7%(28/42), 42.9%(18/42), 81.0%(34/42) and 33.3%(14/42) respectively. The positive rates of the methods mentioned above of the urethral invasion were 83.3%(5/6), 66.7%(4/6), 83.3%(5/6) and 33.3%(2/6). Conclusion The diagnostic accurate rate would be raised if the patients who are suspected with the prostatic adenocarcinoma are examined by the different ways mentioned above.

  19. Diagnóstico y tratamiento de pacientes con linfomas primarios del sistema nervioso central (LPSN y sindrome de inmunodeficiencia adquirida (SIDA

    Directory of Open Access Journals (Sweden)

    Luis E Raez

    1999-07-01

    Full Text Available La incidencia del linfoma primario del sistema nervioso central (LPSNC ha crecido rápidamente. El LPSNC as una complicación letal en pacientes con SIDA. Objetivo: Nuestro objetivo fue estudiar la historia natural, métodos diagnósticos, al tratamiento y los factores pronósticos para la sobrevida de 75 pacientes con LPSNC y SIDA seguidos en el Jackson Memorial Hospital/Universidad de Miami. Resultados: La edad media fue de 37 años. El 84% de los pacientes eran hombres y el 55% hispanos. Factores de riesgo más comunes para SIDA fueron homosexualidad y múltiples compañeros sexuales. La cuenta promedio de CD4 fue de 15/ul y al promedio de LDH fue 1.5 veces al normal. La tomografía computarizada del cerebro mostraba lesiones múltiples en el 44% de los pacientes. Gammagrafia computarizada de emisión de fotones con talio-201 (SPECT del cerebro se realizó en 2/3 de los pacientes. Las histologías más comunes en las biopsias fueron: linfoma inmunoblástico y linfoma de células grandes. La radiación craneana fue ineficiente en el 50% de los pacientes tratados. La sobrevida promedio del grupo fue de 2.2 meses. Análisis univariado y multivariado mostraron que la mayor sobrevida se asociaba con una buena capacidad funcional (ECOG=1-2 vs 3-4. La presencia previa de infecciones oportunistas, la presencia de factores de riesgo de SIDA, las cuentas de CD4, niveles de LDH y raza no mostraron influencia en la sobrevida. Conclusiones: LPSNC es una neoplasia con pronóstico muy pobre y corta sobrevida aun con radioterapia del SNC. La capacidad funcional parece ser al factor de sobrevida más importante. No se encontraron diferencias en la presentación clínica ni el resultado entre pacientes hispanos y no hispanos. ( Rev Med Hered 1999; 10:96-104 .

  20. Determinación de elementos minoritarios, traza y ultratraza en biopsias procedentes de pacientes con diferentes patologías tumorales mediante ETAAS, ICP-OES e ICP-MS utilizando extracción asistida por ultrasonidos y multigestión de bajo volumen

    OpenAIRE

    Millos Alfeiran, Jorge

    2012-01-01

    El objetivo principal de esta tesis doctoral es la determinación de metales minoritarios, traza y ultratraza en tejidos tumorales humanos mediante el desarrollo de metodologías analíticas adecuadas y robustas que permitan obtener resultados precisos y exactos, de manera que puedan ser aplicadas al análisis de rutina. En este sentido, se ha buscado la solución óptima a cada uno de los problemas planteados. Para llevar a cabo este objetivo se han evaluado la extracción ácida asistida por ult...

  1. Fisher criteria vs. thyroid aspiration citology in the diagnosis of hashimoto's thyroiditis Valor de cuatro de los criterios de Fischer comarados con la biopsia tiroidea por aspiración en el diagnóstico de la tiroiditis de Hashimoto

    OpenAIRE

    Constanza Díaz González; Arturo Orrego; Mauricio Orrego; John J. Orrego

    1991-01-01

    One hundred and forty one patients with diffuse goiter were studied In order to evaluate four of Fisher's criteria for the diagnosis of Hashimoto's thyroiditis and to compare them with the result of thyroid aspiration biopsy. The following criteria were Included in the analysis: a) physical characteristics of the gland; b) appearance of the radioisotope scan; c) plasma TSH concentration; d) serum tilters of anti...

  2. Un momento con el maestro

    OpenAIRE

    Poblete Garaycochea, Luis; Universidad Nacional Mayor de San Marcos

    2014-01-01

    Quiero comenzar, manifestando mis experiencias de comunicación teniendo como fundamento teórico a Carl ROGERS, "El camino del Ser", obra que me sirvió de inspiración e identificación con su pensamiento en el proceso del desarrollo como ser humano.

  3. A vueltas con Samuel Beckett

    Directory of Open Access Journals (Sweden)

    José María Fernández Cardo

    2010-01-01

    Full Text Available A propósito de la obra de Lourdes Carriedo, Mª Luisa Guerrero, Carmen Méndez y Fabio Vericat(eds.: A vueltas con Beckett. Aproximaciones críticas en su centenario (Madrid, Ediciones de La Discreta,col. «Bártulos», 2009, 362 páginas, ISBN: 978-84-96322-29-5.

  4. Magnetic resonance imaging-targeted, 3D transrectal ultrasound-guided fusion biopsy for prostate cancer: Quantifying the impact of needle delivery error on diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Peter R., E-mail: pmarti46@uwo.ca [Department of Medical Biophysics, The University of Western Ontario, London, Ontario N6A 3K7 (Canada); Cool, Derek W. [Department of Medical Imaging, The University of Western Ontario, London, Ontario N6A 3K7, Canada and Robarts Research Institute, The University of Western Ontario, London, Ontario N6A 3K7 (Canada); Romagnoli, Cesare [Department of Medical Imaging, The University of Western Ontario, London, Ontario N6A 3K7 (Canada); Fenster, Aaron [Department of Medical Biophysics, The University of Western Ontario, London, Ontario N6A 3K7 (Canada); Department of Medical Imaging, The University of Western Ontario, London, Ontario N6A 3K7 (Canada); Robarts Research Institute, The University of Western Ontario, London, Ontario N6A 3K7 (Canada); Ward, Aaron D. [Department of Medical Biophysics, The University of Western Ontario, London, Ontario N6A 3K7 (Canada); Department of Oncology, The University of Western Ontario, London, Ontario N6A 3K7 (Canada)

    2014-07-15

    Purpose: Magnetic resonance imaging (MRI)-targeted, 3D transrectal ultrasound (TRUS)-guided “fusion” prostate biopsy intends to reduce the ∼23% false negative rate of clinical two-dimensional TRUS-guided sextant biopsy. Although it has been reported to double the positive yield, MRI-targeted biopsies continue to yield false negatives. Therefore, the authors propose to investigate how biopsy system needle delivery error affects the probability of sampling each tumor, by accounting for uncertainties due to guidance system error, image registration error, and irregular tumor shapes. Methods: T2-weighted, dynamic contrast-enhanced T1-weighted, and diffusion-weighted prostate MRI and 3D TRUS images were obtained from 49 patients. A radiologist and radiology resident contoured 81 suspicious regions, yielding 3D tumor surfaces that were registered to the 3D TRUS images using an iterative closest point prostate surface-based method to yield 3D binary images of the suspicious regions in the TRUS context. The probabilityP of obtaining a sample of tumor tissue in one biopsy core was calculated by integrating a 3D Gaussian distribution over each suspicious region domain. Next, the authors performed an exhaustive search to determine the maximum root mean squared error (RMSE, in mm) of a biopsy system that gives P ≥ 95% for each tumor sample, and then repeated this procedure for equal-volume spheres corresponding to each tumor sample. Finally, the authors investigated the effect of probe-axis-direction error on measured tumor burden by studying the relationship between the error and estimated percentage of core involvement. Results: Given a 3.5 mm RMSE for contemporary fusion biopsy systems,P ≥ 95% for 21 out of 81 tumors. The authors determined that for a biopsy system with 3.5 mm RMSE, one cannot expect to sample tumors of approximately 1 cm{sup 3} or smaller with 95% probability with only one biopsy core. The predicted maximum RMSE giving P ≥ 95% for each

  5. ¿Es la resistencia de Mycobacterium leprae a los medicamentos un verdadero motivo de preocupación? Primera aproximación a la vigilancia molecular de pacientes colombianos multibacilares con tratamiento previo para lepra y sin él

    Directory of Open Access Journals (Sweden)

    Martha Inírida Guerrero

    2014-04-01

    Full Text Available Introducción. Colombia no dispone de información sobre farmacorresistencia primaria y secundaria de Mycobacterium leprae al esquema de terapia múltiple de la Organización Mundial de la Salud (OMS y las autoridades de salud pública del mundo han emitido varias recomendaciones, entre las cuales está organizar de inmediato la vigilancia a la resistencia empleando métodos moleculares simples. Objetivo. Determinar la prevalencia de la resistencia de M. leprae a rifampicina, ofloxacina y dapsona en pacientes del Centro Dermatológico Federico Lleras Acosta con tratamiento previo y sin él durante el período de 1985 a 2004. Materiales y métodos. Se realizó un estudio retrospectivo. Mediante muestreo electivo se incluyeron biopsias de pacientes multibacilares: 381 de pacientes nuevos y 560 de pacientes previamente tratados. Se obtuvieron con micrótomo seis cortes de cada biopsia de piel incluida en parafina, y se realizó la extracción de ADN de M. leprae. Se llevó a cabo la amplificación de tres blancos moleculares mediante PCR y se obtuvieron los patrones de resistencia a los medicamentos dapsona, rifampicina y ofloxacina por hibridación inversa. Se recolectaron datos epidemiológicos, clínicos y demográficos para llevar a cabo los análisis. Resultados. De las 941 muestras estudiadas, 4,14 % era resistente a uno o más fármacos, y se detectaron 5,77 y 3,04 % con genotipos resistentes en pacientes nuevos y previamente tratados, respectivamente. La resistencia total para cada fármaco fue de 0,43 % a dapsona, 3,19 % a rifampicina y 1,17 % a ofloxacina. Se encontró una diferencia estadísticamente significativa para rifampicina y para la población total al comparar los resultados de los pacientes no tratados con los de los pacientes tratados previamente. Dos tercios de las muestras resistentes lo fueron a rifampicina sola o combinada. Conclusiones. Los esquemas de terapia múltiple estándar siguen siendo efectivos para los casos de

  6. Con

    DEFF Research Database (Denmark)

    Graudal, Niels

    2016-01-01

    Scientific evidence to support the recommended salt intake of ..., health authorities use BP effects obtained in studies of pre-hypertensive and hypertensive patients to recommend SR in the healthy population and use these biased BP effects in statistical models indirectly to project millions of saved lives. These fantasy projections are in contrast to real data from...

  7. Detection and localization of carcinoma within the prostate using high resolution transrectal gamma imaging (TRGI) of monoclonal antibody directed at prostate specific membrane antigen (PSMA)—Proof of concept and initial imaging results

    Energy Technology Data Exchange (ETDEWEB)

    Franc, Benjamin L., E-mail: francbl@radiological.com [Radiological Associates of Sacramento Medical Group, 1500 Expo Parkway, Sacramento, CA 95815 (United States); Cho, Steve Y. [Department of Radiology, Johns Hopkins University, 600 N. Wolfe Street, Baltimore, MD 21287 (United States); Rosenthal, Seth A. [Radiological Associates of Sacramento Medical Group, 1500 Expo Parkway, Sacramento, CA 95815 (United States); Cui, Yonggang [Brookhaven National Laboratory, 2 Center Street, Upton, NY 11973 (United States); Tsui, Benjamin [Department of Radiology, Johns Hopkins University, 600 N. Wolfe Street, Baltimore, MD 21287 (United States); Vandewalker, Kristen M.N. [Diagnostic Pathology Medical Group, 3301 C. Street, Suite 200E, Sacramento, CA 95816 (United States); Holz, Andrew L.; Poonamallee, Uday [Radiological Associates of Sacramento Medical Group, 1500 Expo Parkway, Sacramento, CA 95815 (United States); Pomper, Martin G. [Department of Radiology, Johns Hopkins University, 600 N. Wolfe Street, Baltimore, MD 21287 (United States); James, Ralph B. [Brookhaven National Laboratory, 2 Center Street, Upton, NY 11973 (United States)

    2013-11-01

    Purpose: Molecular imaging methods may identify primary prostate cancer foci and potentially guide biopsy and optimal management approaches. In this exploratory study, safety and first human imaging experience of a novel solid state endocavity transrectal gamma-imaging (TRGI) device was evaluated. Methods: Twelve patients received 5 ± 0.5 mCi In-111 capromab pendetide (ProstaScint{sup ®}) intravenously and the prostate of each was imaged 4 days later transrectally using an endoluminal cadmium zinc telluride (CZT)-based compact gamma camera (ProxiScan™, Hybridyne Imaging Technologies, Inc.). Immediate and 5–7-day post imaging safety assessments were performed. In those patients with a prostate cancer diagnosis (N = 10), single photon emission computed tomography (SPECT-CT) and magnetic resonance imaging (MRI) of the pelvis were also acquired. Images were reviewed and sites of suspected cancer were localized by prostate quadrant by consensus of two nuclear medicine physicians. Pathology from TRUS biopsy, or surgical pathology following prostatectomy (N = 3) when available, served as the gold standard. Results: There were no serious adverse events associated with TRGI. No focal signal was detected in patients without a diagnosis of prostate cancer (N = 2). Of 40 quadrants evaluated in the cancer cohort (N = 10), 22 contained malignancy. In 8 of these 10 patients, the most focal site of uptake on TRGI corresponded to a prostatic quadrant with biopsy-proven malignancy. In 6 cancer-containing quadrants, TRGI was positive where SPECT-CT was negative; MRI showed a detectable abnormality in only 1 of these 6 quadrants. Qualitative image review of the planar TRGI images for prostate cancer localization was severely limited in some cases by scatter artifact within the vicinity of the prostate gland arising from physiologic urine and blood pool activity from nearby structures. Conclusions: TRGI is a safe imaging method that can potentially detect radiopharmaceutical

  8. Certeza diagnóstica en la mortalidad de una población de pacientes con trasplante cardíaco

    Directory of Open Access Journals (Sweden)

    Marcos Amuchástegui

    2008-01-01

    Full Text Available RESUMENIntroducciónA pesar de que la morbimortalidad en el trasplante cardíaco ha sido motivo de extensoanálisis, la mayoría de los estudios y registros de mortalidad en pacientes trasplantados sebasan sobre datos clínicos. En la bibliografía existen comunicaciones aisladas de autopsiasen pacientes con trasplante cardíaco.ObjetivoDeterminar la importancia de la realización de estudios anatomopatológicos para el diagnósticode causa de muerte en un programa de trasplante cardíaco.Material y métodosSe incluyeron todos los pacientes con trasplante cardíaco fallecidos entre enero 1990 y enero2005. El diagnóstico definitivo de la causa de muerte fue corroborado por autopsia obiopsia de órgano sólido. Las causas de muerte evaluadas fueron falla precoz del injerto,rechazo celular, infección, enfermedad vascular del injerto, neoplasia y otros.ResultadosDurante el período en estudio 73 pacientes fueron sometidos a trasplante cardíaco; de ellos,fallecieron 31. Se obtuvieron 12 autopsias y 7 biopsias de órgano sólido que certificaron lacausa de muerte (61%. La causa de muerte más frecuente fue el rechazo celular mayor degrado III. En el 12,9%, la anatomía patológica difirió de la sospecha clínica de la causa demuerte.ConclusiónLa información clinicopatológica derivada de estudios post mortem es un indicador de nuestrarealidad asistencial y se constituye en un pilar fundamental para el conocimiento y elmanejo futuro de los pacientes trasplantados, por lo que consideramos que la realización deautopsias en estos pacientes es de vital importancia.REV ARGENT CARDIOL 2008;76:292-294.

  9. Literatura con mayúsculas

    Directory of Open Access Journals (Sweden)

    Cerrillo, P.

    2006-11-01

    Full Text Available En este trabajo se presenta un acercamiento alconcepto de la Literatura Infantil y Juvenil a travésde una breve visión diacrítica desde sus orígeneshasta nuestros días, subrayando los usos particularesmás característicos de esta literatura en cadaépoca (didáctico, doctrinal, proselitista…. Ademásde señalar sus coincidencias con la Literatura engeneral, se pone también de relieve sus particularidadesy características específicas, en lo que noes sino un nuevo intento de delimitar la caracterizaciónde la LIJ (contenidos, temática, estructuraliteraria, forma, ediciones… y reivindicar estaLiteratura con mayúsculas.

  10. Nevus sebáceo de Jadassohn: descripción de 261 casos y su asociación con otros tumores

    Directory of Open Access Journals (Sweden)

    Paula Andrea Arango Pérez

    2008-11-01

    Full Text Available El nevus sebáceo de Jadassohn (NSJ es una lesión congénita benigna pero por decenios se la consideró con alto potencial de malignización hacia el carcinoma basocelular (CBC, por lo que se sugería su resección precoz. Series recientes han establecido que muchas de las neoplasias diagnosticadas como malignas eran benignas. Nuestra revisión de 261 casos constituye un aporte al conocimiento del NSJ. Hasta ahora no ha habido series similares en Colombia, y en América Latina las publicaciones no superan los 60 pacientes. MATERIALES Y MÉTODOS: se analizaron 261 casos del archivo de histopatología de la Facultad de Medicina de la Universidad de Antioquia con diagnóstico de NSJ entre 1976 y 2008, incluyendo biopsias y resecciones. RESULTADOS: de los 261 pacientes, 143 eran hombres (54,8% y 118 mujeres (45,2%; la edad promedio fue de 17,4 años; el NSJ estaba presente al nacimiento en el 90,4%. La localización más frecuente fue en el cuero cabelludo (62,5%. Presentaron tumores asociados 28 pacientes: siringocistadenoma papilífero (SCAP 8 casos (3,1%, tumor del infundíbulo folicular (TIF 5 casos (1,9%. Cuatro casos fueron de CBC (1,5% con edad promedio de 40,7 años. Cuatro de 7 tumores diagnosticados previamente como CBC, fueron reclasificados como TIF. DISCUSIÓN: el SCAP fue el tumor más frecuentemente asociado, tal como aparece reportado por otros autores. En esta serie se encontró el TIF con una mayor frecuencia que en la literatura revisada. El CBC fue el único tumor maligno y se presentó solo en adultos. Los resultados de esta serie evidencian un comportamiento benigno del NSJ, por lo que se debiera replantear la necesidad de resección precoz. La revisión histológica del diagnóstico inicial demuestra que lesiones benignas pueden ser confundidas fácilmente con CBC, sobreestimando el potencial maligno de este hamartoma.

  11. pacientes con insuficiencia renal terminal

    Directory of Open Access Journals (Sweden)

    Karen Herrera Herrera

    2011-01-01

    Full Text Available La presente investigación fundamenta en la clínica psicoanalítica el estudio de dos casos de tres personas diagnosticadas con IRT que reciben tratamiento de hemodiálisis, en razón a que dadas las características y el aumento de los reportes que se presentan, ya esto se considera un problema de salud pública. El objetivo principal es describir las características dinámicas del proceso de duelo en pacientes con IRT en un centro de terapia renal de la ciudad de Cartagena. El procedimiento metodológico empleó un diseño de tipo cualitativo; la investigación se desarrolló con un diseño clínico mediante el estudio de casos, y fundamentada en la hermenéutica psicoanalítica. Todo esto respaldado en la historia clínica, la entrevista semiestructurada individual y familiar, los test proyectivos, test del dibujo de la figura humana Machover y TAT de Murray, para la debida integración de los análisis. Se concluye que predominan funciones fallidas de los progenitores y que son individuos provenientes de familias psicosomáticas, que utilizan la enfermedad para obtener un beneficio secundario.

  12. con bajo peso al nacer

    Directory of Open Access Journals (Sweden)

    Adriana Mora Antó

    2005-01-01

    Full Text Available Esta investigación dio cuenta de la relación entre el estilo de funcionamiento familiar, los patrones de crianza y las edades de desarrollo evolutivo en niños, nacidos con bajo peso. El estudio descriptivo correlacional se realizó con 41 niños y sus madres, aplicándose cuestionarios sobre funcionamiento familiar, prácticas de crianza y desarrollo infantil. Los resultados señalaron la existencia de un funcionamiento familiar caracterizado por una cohesión amalgamada y una adaptabilidad caótica, una disciplina complaciente, falta de control y de límites claros en la díada madre-hijo. Se trataba de familias monoparentales, donde la temprana edad de concepción, el madresolterismo y el apoyo de la familia extensa eran constantes. Las edades evolutivas registradas indicaron un desarrollo inferior a la edad cronológica, en la mayor parte de los casos; sin embargo, éstas tendieron a ser superiores al compararlas con la edades reales de los infantes. No se encontró una correlación estadísticamente significativa entre la edad de desarrollo y los diferentes factores del funcionamiento familiar para algunos de los rangos de edad considerados; sin embargo, no se lo descartó por completo, especialmente en lo referente al optimismo familiar

  13. Desensibilización con aspirina en un paciente con intolerancia a antiinflamatorios no esteroides

    OpenAIRE

    Mirta Álvarez Castelló; Lludenich Osoria Mengana; Mercedes Ronquillo Díaz; Raúl Lázaro Castro Almarales; Doguerti Pérez Marrero; José Severino Rodríguez Canosa; Catalina Irarragorri Toledo

    2011-01-01

    El ácido acetilsalicílico o aspirina es uno de los medicamentos más utilizados a nivel mundial. Los pacientes con enfermedad coronaria requieren tratamientos prolongados con este medicamento, el cual se les niega a aquellos con historias de reacciones adversas a este. Se recoge en la literatura internacional el uso de terapias de desensibilización en pacientes con intolerancia a los antiinflamatorios no esteroides con diferentes protocolos, con resultados satisfactorios. En este trabajo se de...

  14. Infiltrados pulmonares en pacientes con cáncer Pulmonary infiltrates in cancer patients

    Directory of Open Access Journals (Sweden)

    Fernando A. Díaz Couselo

    2008-10-01

    Full Text Available La aparición de infiltrados pulmonares en los pacientes con cáncer representa un desafío diagnóstico y terapéutico. Con el objeto de evaluar la etiología, utilización de métodos diagnósticos, admisión en Terapia Intensiva (UTI y letalidad intrahospitalaria de estos pacientes, realizamos un estudio prospectivo observacional donde se incluyeron todos los pacientes con cáncer y nuevos infiltrados pulmonares internados en el Instituto Alexander Fleming entre marzo 2003 y agosto 2006. Los métodos diagnósticos fueron categorizados en 3 etapas (1ª etapa: patrón radiológico de los infiltrados pulmonares, hemocultivos, cultivo de esputo, pruebas serológicas y respuesta al tratamiento empírico inicial; 2ª etapa: lavado broncoalveolar (LBA, aspirado traqueal y mini-LBA; 3ª etapa: biopsias pulmonares o extrapulmonares. La etiología de los infiltrados pulmonares se clasificó como infección, complicación del tratamiento, progresión de enfermedad, cardiovascular o mixta. Los diagnósticos fueron clasificados en diagnóstico de certeza o diagnóstico probable. Se incluyeron 106 casos en 103 pacientes. La etiología fue: infección en 61 casos, progresión de enfermedad en 4, complicación del tratamiento en 6, cardiovascular en 6 y mixta en 7. Se obtuvo diagnóstico de certeza en 33 casos y diagnóstico probable en 51. Se clasificaron como sin diagnóstico 22 casos. Nueve de las 10 micosis diagnosticadas fueron en pacientes oncohematológicos. Setenta casos se detuvieron en la 1ª etapa diagnóstica, 32 en la 2ª etapa y 4 necesitaron biopsias. Requirieron internación en UTI 44 casos. La letalidad intrahospitalaria fue 30.2%. En nuestro estudio, la infección fue la etiología más frecuente y las micosis fueron predominantes en los pacientes oncohematológicos. Se obtuvo diagnóstico de certeza o diagnóstico probable en 84 (79.2% casos. En 53.7% de los casos no se requirieron métodos diagnósticos invasivos.Pulmonary infiltrates

  15. Leishmaniasis cutánea difusa en un paciente con sida Diffuse cutaneous leishmaniasis in a patient with AIDS

    Directory of Open Access Journals (Sweden)

    Carlos Pérez

    2006-12-01

    Full Text Available Objetivo. Estudiar un paciente con leishmaniasis cutánea difusa y sida y comentar el tema.
    Materiales y métodos. Soldado de 29 años, procedente de San José del Guaviare, con pérdida de 18 kilos de peso en los últimos 10 meses y erupción generalizada de dos meses de evolución. El Elisa y el Western blot fueron positivos para virus de inmunodeficiencia humana. Tenía 92 LT CD4/mm3. Presentaba máculas, pápulas y placas eritematoescamosas, psoriasiformes y generalizadas, cuyas biopsias demostraron abundantes microorganismos fagocitados por macrófagos, que se teñían de negro con la coloración de Gomory. Se diagnosticó histoplasmosis diseminada. Se inició tratamiento antirretroviral y antimicótico con itraconazol sin observar mejoría.
    Resultados. La anfotericina B produjo mejoría, pero las lesiones recidivaron más numerosas y nodulares con compromiso oral. Once meses después del comienzo de su enfermedad, nuevas biopsias de piel y la revisión de las anteriores confirmaron que el paciente tenía leishmaniasis cutánea difusa. El cultivo no permitió aislar el parásito. La miltefosina produjo mejoría importante. Las pápulas y máculas recidivaron varios meses después; recibió 52 ampollas de glucantime® durante dos meses, consiguiéndose la curación clínica, situación que permanece dos años y medio después de iniciada la enfermedad.
    Conclusiones. La leishmaniasis cutánea difusa debe plantear sospecha de sida. El tratamiento es difícil; debe ser antirretroviral y antileishmaniásico, con profilaxis antiparasitaria. Los amastigotes de Leishmania no son positivos con la coloración de Gomory en técnicas controladas; se diferencian del histoplasma por morfología, cultivo, inmunohistoquímica, anticuerpos específicos y reacción en cadena de la polimerasa. La asociación leishmaniasissida es beneficiosa para ambos gérmenes; es posible el aumento de casos en Colombia por el auge de ambas entidades

  16. Density-functional calculations of Con+,Con, Con- (n≤5) clusters%Con+,Con,Con -(n≤5)团簇的密度泛函理论研究

    Institute of Scientific and Technical Information of China (English)

    张蓓; 陈楚; 张军

    2011-01-01

    The geometrical and electronic structures of Con+ ,Con,Con- (n≤5) clusters had been investigated using spin-polarized DFT calculations. The ground-state structures of Con+ ,Con,Con- (n≤5) clusters evoluted from one-dimension to three dimensional configurations. The total magnetic moment showed monotonic increase with size up to 5, which alternated with odd and even numbers. The interaction strengths between Con+-1(n≤5) cluster and Co atom were much more stronger. The electronic affinities (EA)and ionization potential (IP)also had been discussed in this work.%本文采用基于自旋极化的密度泛函理论系统研究了Con+,Con,Con- (n≤5)团簇的几何结构和电子结构特性.随尺寸的递增,Con,Con± (n≤5)团簇的基态几何结构由一维演变为三维的几何构型.总磁矩随尺寸的增加线性递增,并呈现奇偶交替的现象,从Con,Con±(n≤5)团簇系统中分离一个Co原子带正电的团簇体系需要的能量相对较大.本文对体系的电子亲和能(EA)以及离化势(IP)也进行了讨论.

  17. Delirio dermatozoo en pacientes con organicidad

    Directory of Open Access Journals (Sweden)

    Ricardo Humarán Fernández

    1995-04-01

    Full Text Available Se presentan 2 pacientes con diagnóstico de delirio dermatozoo, al realizar una revisión de dicha entidad a propósito de la presentación; en ambos casos aparece una asociación causal con la afección orgánica. El tratamiento indicado con fluspirileno resultó novedoso y de buena evolución, y no había sido reportado con anterioridad.

  18. Welfare – con o senza stato

    DEFF Research Database (Denmark)

    Bengtsson, Steen

    Welfare – con o senza stato analizza una vasta gamma di servizi sociali presenti a Padova, comprandoli con quelli di una cittá di dimensioni simili, Århus. La ricerca pertanto illustra la concreta erticolazione del sisterma di sicurezza sociale danese, confrontadolo con quello realizzato del nord...

  19. Tratamiento del paciente con artrosis

    OpenAIRE

    2014-01-01

    El manejo terapéutico del paciente con artrosis tiene como objetivo disminuir la sintomatología dolorosa e inflamatoria, mejorar la capacidad funcional del paciente y la aplicación de intervenciones terapéuticas eficaces y lo más seguras posibles. Un enfoque centrado en el paciente implica su participación activa en el diseño del plan terapéutico y en la toma de decisiones informadas oportunas en todas las etapas de la enfermedad. La educación terapéutica, la actividad física y el ejercicio t...

  20. Conversando con... ALBERTO CAMPO BAEZA

    OpenAIRE

    Granero Martín, Francisco; Millán-Millán, Pablo-M.

    2014-01-01

    [EN] Interview with Alberto Campo Baeza, who is an architect and Project profesor in the Architecture School of Madrid. He has just been awarded the Teachinbg Excellency Award issued by the Technical University of Madrid and the 2013 Tessenow Gold Medal [ES] Entrevista con Alberto Campo Baeza, que es arquitecto y catedrático de proyectos de la Escuela de Arquitectura de Madrid. Acaba de recibir el Premio de Excelencia Docente de la Universidad Politécnica de Madrid y la Medalla de Oro Tes...

  1. Paniculitis en paciente con dermatomiositis

    OpenAIRE

    Arias,Mariana; Hernández,María Inés; Cunha,Lais Gomes Barbosa; Kien,María Cristina; Abeldaño, Alejandra

    2011-01-01

    La paniculitis es una manifestación cutánea infrecuente de la dermatomiositis. Puede preceder hasta en 14 meses a otras manifestaciones de la dermatomiositis. En todos los casos, la miositis y la paniculitis presentan mejoría simultánea durante el tratamiento. Describimos una paciente de sexo femenino de 30 años que presenta lesiones clínica e histológicamente compatibles con paniculitis luego de 2 meses de que el compromiso muscular y cutáneo permitió el diagnóstico de dermatomiositis. Las l...

  2. 不育男性前列腺中线囊肿经直肠超声检查及精液特点分析%Transrectal ultrasonographic features of midline prostatic cysts in infertile men and their semen analysis

    Institute of Scientific and Technical Information of China (English)

    顾怡栋; 邓学东; 杨慎敏; 姜纬; 李红

    2015-01-01

    目的分析男性不育患者前列腺中线囊肿经直肠超声表现和精液特点。方法对2013年11月至2014年10月在南京医科大学附属苏州医院超声中心就诊的34例男性不育患者经直肠超声表现及精液特点进行分析。结果34例男性不育超声显示前列腺中线囊肿的患者声像图均表现为前列腺内无回声区,其中射精管囊肿17例,囊肿一侧与同侧精囊相连,纵切面声像图示囊肿呈倒置水滴状尖端指向精阜;苗勒管囊肿11例,囊肿位于前列腺基底部、尿道后上方中线处,纵切面声像图呈水滴状或类圆形;真性前列腺囊肿6例,囊肿位于前列腺内部或前列腺包膜下,横切面及纵切面声像图呈圆形或类圆形,根据囊肿的解剖位置及形态可加以鉴别。精液检测分析提示射精管囊肿患者中无精子症13例,少精子症2例;苗勒管囊肿患者中无精子症4例,少精子症6例;真性前列腺囊肿患者中无精子症1例,少精子症2例。结论经直肠超声检查可对前列腺中线囊肿解剖位置及形态做出准确诊断,与精液分析相结合可为临床治疗提供可靠的依据。%Objective To investigate the transrectal ultrasonographic (TRUS) features of midline prostatic cysts and the semen analysis in infertile men. Methods The ultrasonographic characteristics of midline prostatic cysts were retrospectively analyzed in 34 infertile men, who underwent transrectal ultrasound and semen analysis in Suzhou Hospitial Affiliated to Nanjing Medical University from November 2013 to October 2014. Results Thirty-four patients were detected by transrectal ultrasound with anechoic areas in their prostates. Among them, the cysts could be divided into 3 groups:17 ejaculatory duct cyst, 11 mullerian duct cyst and 6 true prostatic cyst. Ejaculatory duct cysts was connected with ipsilateral seminal vesicle and pointed to seminal hillock showing a water-drop shape on longitudinal

  3. Pericarditis purulenta con taponamiento cardíaco por asociación de Streptococcus agalactiae y Salmonella enterica no typhi Purulent pericarditis with pericardial tamponade caused by Streptococcus agalactiae and Salmonellaenterica no typhi

    Directory of Open Access Journals (Sweden)

    Lourdes Arruvito

    2004-08-01

    Full Text Available La pericarditis purulenta (PP es una condición infrecuente, pero con elevada mortalidad. Previo a la era antibiótica, los agentes etiológicos más comúnmente hallados eran Streptococcus pneumoniae y Staphylococcus aureus. Se presenta el caso de un paciente de sexo masculino de 75 años de edad con un cuadro de shock, PP y taponamiento cardíaco, producto de una sepsis por Streptococcus agalactiae y Salmonella entérica no typhi. No se ha hallado ningún caso similar en la literatura. Se destaca el antecedente previo inmediato de la realización de una endoscopia digestiva alta con toma de biopsia de esófago como posible causa de bacteriemia e impacto pericárdico. El curso evolutivo fue malo y el paciente falleció a los 34 días. Esta inusual asociación bacteriana en un huésped debilitado e inmunodeprimido, debería ser incluida dentro de los diagnósticos etiológicos diferenciales de la pericarditis purulenta.Purulent pericarditis (PP is an uncommon condition with high mortality. In the preantibiotic period, Staphyloccocus aureus and Streptococcus pneumoniae were the most common etiologic agents. We describe the case of a 75-year old man with septic shock, PP and cardiac tamponade caused by Streptococcus agalactiae and Salmonella enterica no-typhi. To our knowledge this association of pathogenic organisms has not been previously reported in the literature. The pathogenesis is here reviewed, and in our patient presumably, purulent pericarditis occurred via hematogeneus spread undergoing upper gastrointestinal endoscopy. The patient’s course was complicated and he died on 34 th hospital day. After this case report it is considered that differential etiologic diagnosis of PP should include these agents, especially in immunodepressed patients with predisposing factors.

  4. Abdomen agudo quirúrgico en pacientes infectados con el Virus de Inmunodeficiencia Humana en el Hospital Nacional Cayetano Heredia

    Directory of Open Access Journals (Sweden)

    Franklin Martinez Yactayo

    2004-10-01

    Full Text Available Objetivo: Determinar las características epidemiológicas y clínico quirúrgicas del abdomen agudo quirúrgico (AAQ en pacientes con diagnóstico de infección por el Virus de Inmunodeficiencia Humana (VIH. Material y métodos: Estudio descriptivo retrospectivo de serie de casos en el Hospital Nacional Cayetano Heredia (HNCH durante el periodo 1997 - 2002. Resultados: Se incluyeron 23 pacientes: 19 varones y 4 mujeres; las manifestaciones clínicas fueron: dolor abdominal, signos de irritación peritoneal, fiebre, nauseas, ruidos hidroaéreos disminuidos y distensión abdominal. Los procedimientos quirúrgicos realizados fueron: resección intestinal (26.1%, apendicectomía (26.1%, biopsia de ganglios (21.74%, colecistectomía (17.4%, lisis de bridas y adherencias (4.35%, drenaje de absceso (4.35% y resección tumoral (4.35%. Se realizó estudio anatomopatológico en 82.61%. La morbilidad fue 56.5%, debidas a: neumonía (26.1%, infección de herida operatoria (21.74%, fístula enterocutánea de gasto alto (21.74%, fiebre (21.74%, dehiscencia de herida operatoria (13%, trastorno hidroelectrolítico (13%, diarrea persistente (8.7%, deshidratación moderada (8.7%, íleo paralítico (4.35% y, síndrome adherencial (4.35%. El 50% de resecciones intestinales por perforación intestinal presentaron fístulas enterocutáneas. La mortalidad post operatoria fue 21.74%. Conclusiones: El 1.82% de pacientes infectados por el VIH, atendidos en el HNCH presentaron AAQ. Los procedimientos quirúrgicos más frecuentes fueron: apendicectomía convencional y resección intestinal con anastomosis. El examen anatomopatológico mostró: bacilo de Koch, seguido de Citomegalovirus y linfoma no Hodgkin. En el 26.1% de los casos se realizaron intervenciones quirúrgicas (laparotomías innecesarias. Las complicaciones post operatorias más frecuentes fueron: neumonía (26.1%, infección de herida operatoria (21.74%, fístula enterocutánea de gasto alto (21.74% y

  5. Food irradiation - pros and cons

    Energy Technology Data Exchange (ETDEWEB)

    1983-01-01

    The use of ionising radiation for food preservation is a much-disputed topic, both among experts and among consumers. Pros and cons of this issue were discussed in detail at the consumers' forum. Professor Dr. Johannes Friedrich Diehl, Director of the Institute for Biochemistry of the Food Research Centre, Karlsruhe, is a well-known supporter of the new method of food preservation; he sees advantages in the radiopreservation of food because, for example, losses due to inedibility are reduced, the danger of salmonellosis is decreased, just as the use of chemicals. He thinks this method to be without danger to health, shown by many years of experience. Opponents to food irradiation like Prof. Dr. Konrad Pfeilsticker, Professor for food science and food chemistry at the Bonn University deem the method to be unnecessary and raise the problem of qualitative changes caused in the food. In the course of the discussions, the pros and cons seemed to balance each other out.

  6. Tratamiento del paciente con artrosis

    Directory of Open Access Journals (Sweden)

    Francisco Vargas Negrín

    2014-01-01

    Full Text Available El manejo terapéutico del paciente con artrosis tiene como objetivo disminuir la sintomatología dolorosa e inflamatoria, mejorar la capacidad funcional del paciente y la aplicación de intervenciones terapéuticas eficaces y lo más seguras posibles. Un enfoque centrado en el paciente implica su participación activa en el diseño del plan terapéutico y en la toma de decisiones informadas oportunas en todas las etapas de la enfermedad. La educación terapéutica, la actividad física y el ejercicio terapéutico junto con el control de peso, en caso de sobrepeso u obesidad, constituyen el núcleo central del tratamiento. Los autocuidados individuales y por los familiares son fundamentales en el control del día a día del paciente. El uso de terapias físicas, ayudas técnicas (bastón, etc. y de fármacos tipo analgésicos simples, opioides y antiinflamatorios tiene evidencias demostradas en el control del dolor, mejora la funcionalidad y la calidad de vida del paciente y una clara recomendación de uso en el tratamiento de la artrosis. La cirugía conservadora y la de reemplazo articular se indican en los casos en los que no se logran los objetivos terapéuticos en casos concretos.

  7. De paseo con los Bourbaki

    Directory of Open Access Journals (Sweden)

    Miquel Escudero

    2012-04-01

    Full Text Available Setenta y siete años después de la fundación del grupo Bourbaki, procedemos a una reflexión que puede ser útil para los estudiantes que acaso no sepan de su existencia, ni tan siquiera los de matemáticas. Sería interesante conocer que a este grupo se le debe el signo del vacío como conjunto. Con todo lo discutible que sea el método Bourbaki en su reinterpretación de la matemática, no cabe duda de su importante repercusión hasta el punto de que ha marcado una época. Hay un antes y un después tras su irrupción, ningún matemático de primera fila de la segunda mitad del siglo XX fue ajeno a su influjo, para encabezarlo o para reprobarlo. Comenzaron como una juvenil extravagancia, pero repleta de conocimientos y con decidida voluntad de aprehender el rigor de forma exhaustiva.

  8. RASGOS DE PERSONALIDAD EN PACIENTES CON OBESIDAD

    Directory of Open Access Journals (Sweden)

    Alejandra Bravo Del Toro

    2011-01-01

    Full Text Available El presente estudio analizó los rasgos de personalidad con mayor incidencia en una población mexicana con obesidad. Se distinguieron los rasgos que intervienen en el funcionamiento diario de los sujetos. La muestra estuvo conformada por 60 pacientes: 31 hombres y 29 mujeres, con edades de 30 a 40 años, casados, con nivel educativo básico y que acudían a consulta médica en un centro de diagnóstico clínico, con antecedentes de obesidad. Se utilizó el perfil-inventario de la personalidad de Gordon, según el cual se comprobó que los pacientes con obesidad tienden a mostrar rasgos de personalidad por debajo de la norma. Los análisis demostraron relaciones significativas entre la gente obesa y cada uno de los rasgos de personalidad con menor prevalencia que mide la escala.

  9. Research on the prediction of the outcome of medical abortion by transrectal ultrasonography%经直肠超声检查预测药物流产结局的研究

    Institute of Scientific and Technical Information of China (English)

    郭玮; 郭敏

    2012-01-01

    目的 探讨经直肠超声在预测药物流产结局方面的临床应用价值.方法 选择120例无任何合并症和并发症的药物流产妇女,于药物流产后第3天经直肠超声观察宫腔情况.根据宫腔内容物血流信号特征,分为Ⅰ、Ⅱ、Ⅲ型;根据宫腔内容物最大前后径,分为A(<10.0 mm)、B(11.0~30.0 mm)和C(>30.0 mm)三组;并随访各组药物流产结局.结果 Ⅰ、Ⅱ、Ⅲ型患者药流成功率依次为95.83%、31.03%、0;清宫率依次为0、17.24%及100%;A、B、C三组患者药流成功率依次为94.67%、3.03%、0;清宫率依次为0、24.24%、100%,且各组间比较差异有统计学意义(P<0.05).此外,随着血流信号丰富程度的增加,宫腔内容物大小呈逐渐上升趋势,差异有统计学意义(P<0.01).结论 应用直肠超声观测宫腔情况对预测药物流产结局有一定的指导意义.对于宫腔内容物血流信号丰富且体积较大的药物流产患者,应加强监测,可积极行清宫术.%Objective To explore the value of transrectal ultrasonography in predicting the outcome of medical abortion. Methods One hundred and twenty women who received medical abortion without any complications were enrolled in the study. Transrectal ultrasonography was performed to observe the situation of uterine cavity three days after medical abortion. Subjects were divided into group I , II and IE according to the features of blood flow signal in uterine cavity contents. Subjects were divided into group A(30.0 mm) according to the maximum diameter of uterine cavity contents. The outcome of medical abortion in all groups was followed. Results The success rate of medical abortion of group I , II and IH was 95.83% , 31.03% and 0, while the ratio of additional curettage was 0, 17.24% and 100% , respectively. By contrast, the success rate of medical abortion of group A, B and C was 94.67% , 3.03% , and 0, and the ratio of additional curettage was 0, 24.24% and

  10. Cons ICARUS, TIGER and Fascism

    Directory of Open Access Journals (Sweden)

    Janez Vrečko

    2010-12-01

    Full Text Available Like the scientists of their time, Russian artists in the 1920s considered gravity the central problem – a view which points to the close harmony between modern physics and the avant-garde. It was only with the constructivist movement that the Icarus revolution grasped the principles of the “mobile philosophy” (3.651 which was almost at the same time recognised by modern physics as well. The static view of the world became obsolete, space and time were no longer absolute values. It was necessary to transcend Euclidean geometry, shake off the political ʻshackles on one’s hands’ and surrender to Lisicki’s imaginary space, where “At 2000 metres in the air / there is no more perspective” (Integrals 276.  Kosovel’s Icarus project accorded with Tatlin’s, and both of them accorded with the quintessential aims of the constructivist movement. It is no accident that Kosovel wished to name one of his poetry collections The Dream of Icarus. Poems on the Icarus theme, such as “Cons Icarus”, “Evacuation of the Spirit”, “Eh, Hey”, “A Heart in Alcohol” etc. belong to the group of Kosovel’s conses which follow his “mobile philosophy” (3.650 and “letters growing into space” (Int. 282.  The question “Man, do you want up in the air?” (Int. 128 will remain a question until the moment when man is finally ready to transcend the existing boundary and dive “beyond”. Hence Kosovel’s clear-cut contrast between the “green windows of an illuminated / express on a viaduct”, which moves horizontally and is, like a water current, subject to the earth’s gravity, and “the spirit in space”, whose direction of motion is “the perpendicular of the spirit”, atectonicity. “The spirit burns in space”: fire is an element that knows vertical movement alone, the only one of the elements to outgrow and transcend the earth’s gravity, therefore it is associated with another mythological figure important for

  11. Tratamiento de las úlceras crónicas en los miembros inferiores con un equivalente cutáneo autólogo y desbridación con larvas de Lucilia sp. (Diptera: Calliphoridae. Reporte de un caso. Chronic lower limb ulcers treatment with autologous skin equivalent and larvae debriding (diptera calliphoridae

    Directory of Open Access Journals (Sweden)

    Sergio Estrada Mira

    2007-12-01

    Full Text Available Introducción: las úlceras en los miembros inferiores constituyen una causa importante de hospitalización y deterioro en la calidad de vida de los pacientes, al interferir con sus actividades laborales y sociales. Estas lesiones obedecen a diferentes enfermedades, la más frecuente de las cuales en Medellín es la insuficiencia venosa; una vez diagnosticadas, existen muchas alternativas de tratamiento, que buscan crear un lecho apropiado para el cierre de la herida. El uso de larvas para el desbridamiento es una alternativa rápida y de bajo costo, con la cual se logra un tejido de granulación adecuado para la aplicación de equivalentes cutáneos autólogos, que constituyen una opción para pacientes refractarios a otros tratamientos. Materiales y métodos: se seleccionó y evaluó a una paciente de acuerdo con los criterios de inclusión establecidos para el estudio. Para desbridar la úlcera se recurrió a la aplicación de larvas de Lucilia sp. (Diptera: Calliphoridae, obtenidas a partir de huevos previamente desinfectados con hipoclorito de sodio y sembrados en un medio de cultivo con antibióticos. Se aplicaron las larvas directamente en la lesión y posteriormente se procedió a tapar esta con muselina, permitiendo la obtención de oxígeno y facilitando el drenaje del tejido necrótico. Las larvas se dejaron por 48 horas, al cabo de las cuales se retiraron con una pinza estéril y se descartaron en alcohol al 70%; luego se procedió a evaluar la limpieza de la lesión. Este procedimiento se llevó a cabo en el Laboratorio de Entomología (GIEM de la Universidad Antioquia. Se procesó una biopsia de piel de la paciente, obtenida siguiendo un protocolo previamente establecido, para obtener queratinocitos y fibroblastos. Para el cultivo primario de queratinocitos el 90% de las células obtenidas de la biopsia se sembró en cajas de cultivo de 75 cm2, en presencia de 7 x 106 células de la línea 3T3- Swiss tratadas con mitomicina C (10 g

  12. AB226. The effects of transrectal radiofrequency hyperthermia on patients with chronic prostatitis and the changes of IL-8, IL-10, TNF-α, PGE2, β2-endorphin levels in pre-treatment and post-treatment

    Science.gov (United States)

    Ding, Hui; Gao, Mingdong; Lu, Jianzhong; Wang, Hanzhang; Li, Qinfang; Wang, Zhiping

    2014-01-01

    Objective To assess the effectiveness of transrectal radiofrequency hyperthermia in men with chronic prostatitis (CP), and explore the changes of IL-8, IL-10, TNF-equency hyperthermia in men wi CP patients pre-treatment and post-treatment. Materials and methods Patients diagnosed with chronic prostatitis were randomized to 6 weeks of tamsulosin plus clarithromycin, transrectal radiofrequency hyperthermia (TRFH) or TRFH with tamsulosin plus clarithromycin group, respectively. The primary outcome measure was evaluated by the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI). The expression of EPS interleukin-8 (IL-8), interleukin 10 (IL-10), tumor necrosis factor (TNF-α), prostaglandin E2 (PGE2) and β2-endorphin (βNIH-) were detected by ELISA in the pre-treatment and post-treatment of CP. Results A total of 159 patients were randomized in the study. The NIH-CPSI total, domain and pain scores significantly decreased from baseline in all groups, After treatment, IL-8 and IL-10 was significantly decreased in the TRFH with tamsulosin plus clarithromycin group compared to the other two groups(P<0.05), Among the three groups, there was no significant changes of TNF-, domain and pain scores significantly, the levels of PGE2 was significantly decreased (P<0.05), while the TNF-, domain and pain scores significantly decreased from baseline in all groin plus clarithromycin group compared to the tamsulosin plus clarithromycin group (P<0.05). In the CP patients, the results showed that there was a significant negative correlation between β2-EP and pain (r=–0.747, P<0.05) or QoL (r=–0.595, P<0.05), while there was a significant positive correlation between TNF-α and micturition (r=0.619, P<0.05) or QoL (r=0.663, P<0.05), between PGE2 and pain (r=0.650, P<0.05) or QoL (r=0.685, P<0.05). Conclusions Comparison with pre-treatment, differences in IL-8, IL-10, TNF-ɑ,PGE2 and with pre-treatment, differences in IL-8, IL-10, TNF-ɑn TNF-α and

  13. Fare astronomia con piccoli telescopi

    CERN Document Server

    Gainer, Michael K

    2007-01-01

    Non sono necessariamente richiesti strumenti mastodontici per produrre risultati scientificamente validi nel campo dell’astronomia. Anche l’astrofilo dotato di un piccolo telescopio, con un diametro di soli 8-9 cm, può contribuire alla scienza del cielo realizzando utili osservazioni del Sole, della Luna, dei pianeti, delle comete, degli asteroidi, delle stelle doppie o variabili, delle nebulose e degli ammassi stellari. Il manuale di M.K. Gainer spiega quale sia la dotazione minima (un piccolo telescopio, un computer, una semplice fotocamera digitale), come utilizzarla, e quali siano le tecniche appropriate da adottare nelle osservazioni. Offre inoltre schemi per interpretare e ridurre i dati raccolti, nonché schede da compilare e da spedire ai centri di raccolta internazionali. Questo libro è il passaporto grazie al quale l’astrofilo può entrare a pieno titolo nel mondo affascinante della scienza astronomica.

  14. Un tema con muchas variaciones

    Directory of Open Access Journals (Sweden)

    Bárbara Kepowics Malinowska

    2003-01-01

    Full Text Available Se aborda el tema de ética y valores como uno de los ejes principales de la formación de la identidad de los futuros profesionistas. Se presentan los resultados de una investigación realizada con metodología cualitativa, para conocer la relación entre los valores explícitos en el proyecto universitario y los valores en los estudiantes al culminar su carrera en la Universidad. Entre las principales conclusiones, cabe destacar la heterogeneidad de los valores vividos a través de las prácticas curriculares, una discrepancia significativa entre ellos y los valores declarados en los proyectos y, por consecuencia, una diferencia entre los valores deseables y los asumidos como compromiso personal. Predomina la ética de la conveniencia y hay poca conciencia de la profesión, entendida como un servicio de calidad para la sociedad.

  15. Análisis de la inestabilidad de microsatélites mediante el marcador BAT-26 en una muestra de pacientes del Hospital Universitario de Santander con diagnóstico de cáncer gástrico o colorrectal

    Directory of Open Access Journals (Sweden)

    Wilmer Cárdenas

    2008-06-01

    Full Text Available Introducción: La vía de inestabilidad de microsatélites se ha encontrado sobre todo en cánceres de vías digestivas, de los cuales 90% de los casos pertenecen a pacientes con cáncer hereditario y 15% con cáncer esporádico. De ella se deriva un fenotipo denominado de inestabilidad de microsatélites (IMI+ o fenotipo de error de la replicación (RER+ que induce a la acumulación de mutaciones en tasas más elevadas a las normales. Objetivos: Identificar la presencia del fenotipo IMI+ en los pacientes analizados y evaluar su relación con la diferenciación histopatológica del tumor porque en conjunto han sido asociados con un mejor pronóstico y una mejor respuesta al tratamiento dado. Metodología: Se extrajo ADN de las muestras de sangre (células normales y las biopsias de tumor (células tumorales de los 23 pacientes que se pudieron incluir para el estudio y mediante la amplificación por PCR y posterior electroforesis capilar; se tipificó el microsatélite mononucleotídico BAT-26, empleado por su sensibilidad para descubrir el fenotipo IMI+. Finalmente se hizo una correlación estadística según la presencia (IMI+ o ausencia (IMI- del fenotipo, con los hallazgos histopatológicos utilizando la prueba exacta de Fisher. Resultados: Del total de pacientes, 4 (17% presentaron IMI+: 3 de ellos con cáncer colorrectal (2 casos posiblemente con cáncer hereditario y uno con cáncer gástrico. No se encontró ninguna asociación entre el fenotipo IMI+ con el diagnostico patológico, la edad, el sexo y la diferenciación histopatológica del tumor. Conclusión: Se encontró el fenotipo IMI+ en 17% de los casos, sin asociación con el grado de diferenciación histopatológica del tumor, posiblemente por el reducido número de muestras tipificadas, por lo cual es indispensable revisar los métodos de fijación, parafinación y almacenamiento de tejidos, pues las técnicas actuales dificultan la digestión de la proteinaza k y la PCR.

  16. La atención a los padres con hijos con necesidades educativas especiales (NEE

    Directory of Open Access Journals (Sweden)

    Claudia María Pernas Pico

    2011-01-01

    Full Text Available Los padres que tienen hijos con necesidades educativas especiales (NEE necesitan al igual que sus hijos de la intervención del maestro de Audición y Lenguaje con el objetivo primordial de mejorar la comunicación y el lenguaje de los niños. Se pretende en este artículo dar un abanico de posibilidades de cómo se puede intervenir con los padres desde las escuelas: con largas horas de reuniones, con formación, con talleres, con actividades y juegos, con libretas viajeras, con pequeñas pautas, etc... Siempre desde la empatía y la profesionalidad que debe transmitir el maestro de Audición y Lenguaje. Cambiando la preocupación de los padres por su ocupación.

  17. Manejo del embarazo prolongado con conducta expectante

    OpenAIRE

    Corrales Gutiérrez, Alexis

    2008-01-01

    Estudio sobre el Manejo del Embarazo Prolongado con conducta expectante tiene como fundamental objetivo demostrar que con una práctica obstétrica menos invasiva, se pueden obtener buenos resultados perinatales. Se asiste a una cada vez mayor tendencia mundial a interrumpir el embarazo incluso en la semana 41, con lo que se plantea mejorar los resultados en lo que a morbimortalidad perinatal se refiere. El protocolo de asistencia establecido en la Maternidad “Mariana Grajales” de Santa Clara, ...

  18. Problemas relacionados con el alcohol en personas con conducta deambulante de La Habana

    OpenAIRE

    Beatriz Almaguer Barroso; Alejandro David González López

    2014-01-01

    Fundamento: el consumo irresponsable de alcohol es uno de los problemas más comunes que presentan las personas con conducta deambulante. Objetivo: identificar los problemas relacionados con el alcohol que presentan los sujetos que se encuentran en el Centro de Atención a Personas con Conducta Deambulante de La Habana.Métodos: se realizó un estudio descriptivo de corte transversal. Se aplicó el cuestionario para la identificación de trastornos relacionados con el alcohol en 80 personas con con...

  19. Tiroiditis autoinmune inducida por interferón en pacientes con infección por virus de la hepatitis C. Interferon-induced autoimmune thyroiditis in a patient with hepatitis C virus infection

    Directory of Open Access Journals (Sweden)

    José L. Pinto

    2011-06-01

    Full Text Available Se reporta el caso de un varón de 43 años de edad, sin antecedentes patológicos de importancia, que acudió por elevación asintomática de la alanino aminotransferasa (ALT. El paciente negó ser bebedor crónico de alcohol. Se hizo el diagnóstico serológico de infección activa por hepatitis C y la biopsia de hígado reveló inflamación crónica activa. Con estos resultados, se inició tratamiento con interferón-alfa y ribavirina. Durante el tratamiento de 48 semanas, el paciente presentó anticuerpos antitiroideos positivos con variaciones en sus niveles de tirotropina (TSH y hormonas tiroideas. En el seguimiento postratamiento, el paciente continuó con hipertiroidismo por enfermedad de Graves. La tiroiditis autoinmune es una complicación frecuente del uso de interferón en pacientes con hepatitis C. En algunos casos se presenta como hipertiroidismo por enfermedad de Graves. Se debe evaluar la función tiroidea y los anticuerpos antitiroideos antes y durante el tratamiento con interferón.A 43 year old man presented with asymptomatic elevation of alanine aminotransferase (ALT and no relevant past history. The patient denied being a chronic alcohol drinker. Work-up revealed an active hepatitis C, and liver biopsy showed active inflammation. Treatment was started with interferon-alfa and ribavirin. During the 48 weeks of treatment, the patient developed positive thyroid antibodies with varying level of thyrotropin (TSH and thyroid hormones. At follow-up after treatment, the patient continued with hyperthyroidism due to Graves’ disease. Autoimmune thyroiditis is a common complication of using interferon in patients with hepatitis C. In some cases, it is presented as hyperthyroidism because of Graves’ disease. Thyroid function and thyroid antibodies should be evaluated before and during treatment with interferon.

  20. Aprende Ajedrez con Rey - Parte 2

    OpenAIRE

    ESTÉVEZ MONTERO, RAÚL; Lloret Mauri, Jaime

    2016-01-01

    Es una pieza audiovisual creada con el objeto de atraer la atención de los niños de muy corta edad con el ajedrez y familiarizarlos con todas sus piezas y movimientos. Es una animación dirigida a un público infantil presentada por dibujos animados en 2D, en la que se ha intentado respetar en todo momento el argot de la comunidad ajedredística. En este video se presenta la segunda parte. Estévez Montero, R.; Lloret Mauri, J. (2016). Aprende Ajedrez con Rey - Parte 2. http://hdl.handle.net/1...

  1. Aprende Ajedrez con Rey - Parte 1

    OpenAIRE

    ESTÉVEZ MONTERO, RAÚL; Lloret Mauri, Jaime

    2016-01-01

    Es una pieza audiovisual creada con el objeto de atraer la atención de los niños de muy corta edad con el ajedrez y familiarizarlos con todas sus piezas y movimientos. Es una animación dirigida a un público infantil presentada por dibujos animados en 2D, en la que se ha intentado respetar en todo momento el argot de la comunidad ajedredística. En este video se presenta la primera parte. Estévez Montero, R.; Lloret Mauri, J. (2016). Aprende Ajedrez con Rey - Parte 1. http://hdl.handle.net/1...

  2. Hologramas multipresenciales en 3D con Kinect

    OpenAIRE

    Sánchez Sanabria, José Miguel

    2012-01-01

    El dispositivo de Microsoft Kinect se utiliza normalmente para videojuegos (Xbox360) pero también se puede programar para darle una utilidad deseada según sus funciones. Esto se consigue con el SDK de Microsoft para Windows 7. El dispositivo permite reconocer por infrarrojos profundidad, formas, gestos y también dispone de unos micrófonos con los que reconoce el audio. Los Hologramas siempre han sido algo relacionado con la ciencia ficción desde sus inicios con Star Wars, pero ahora existe...

  3. Sistema digital para realizar biopsia estereotáxica

    OpenAIRE

    Lozano Fantoba, Manuel; Ullán Comes, Miguel; Sentís i Crivillé, Melcior; Chmeissani, Mokhtar

    2007-01-01

    Referencia OEPM: P200401878 .-- Fecha de solicitud: 29/07/2004.-- Titulares: Udiat Centre Diagnostic, S.A., Institut de Fisica d'Altes Enerties (IFAE), Consejo Superior de Investigaciones Científicas (CSIC).

  4. Complications and risk factors in transrectal prostate biopsies%经直肠前列腺穿刺活检术后并发症的原因分析

    Institute of Scientific and Technical Information of China (English)

    庄红雨; 彭涛; 许学敏

    2013-01-01

    目的 分析经直肠前列腺穿刺活检术后并发症发生的原因,提高诊治水平.方法 收集2002年1月至2012年6月北京安贞医院经直肠前列腺穿刺活检术1127例患者的病历资料进行回顾性分析.分析年龄、前列腺体积、总前列腺特异抗原(tPSA)、穿刺针数、口服抗凝药及病理结果等与并发症的关系.结果 1127例经直肠前列腺穿刺活检术患者发生并发症81例.1127例患者中,因感染中毒性休克死亡1例,发生血尿40例(3.5%),直肠出血8例(0.7%),其中5例较严重直肠出血,可于直肠镜下见直肠前壁黏膜点状缺损伴活动性出血;尿潴留21例(1.9%),发热10例(0.9%),迷走性晕厥2例(0.2%).并发症组平均年龄[(65±5)岁]高于无并发症组[(64±6)岁],差异有统计学意义(P =0.048).2组患者的平均前列腺体积、tPSA水平相近,组间差异均无统计学意义(均P>0.05).不同穿刺针数(6、8~12、>12针)及是否口服抗凝药者血尿、直肠出血、尿潴留、发热和迷走性晕厥发生率的差异均无统计学意义(均P>0.05).前列腺增生患者经直肠前列腺穿刺活检术后直肠出血发生率[0.5% (5/997)]低于前列腺癌者[2.3% (3/130)],差异有统计学意义(P=0.021);血尿、尿潴留、发热和迷走性晕厥发生率的差异无统计学意义(均P>0.05).结论 经直肠前列腺穿刺活检术是安全的,但对于高龄患者、高度怀疑前列腺癌者应警惕术后并发症的发生.%Objective To analyze the causes of the following complications after the trans-rectal prostate biopsy.Methods Transrectal prostate biopsy medical records of 1127 patients from January 2002 to June 2012 in Beijing Anzhen hospital were analyzed retrospectively,including age,prostate volume,tPSA level,biopsy needles,oral anticoagulants and pathological characters.Results 1 of 1127 patients died of septic shock.Major complications showed hematuria in 40 patients (3.5%),rectal bleeding in 8

  5. The Impact of Free/Total PSA Ratio on Prostate Cancer Diagnosis in Patients with PSA Level Between 2,5-10 mg/dl Undergoing Transrectal Prostate Biopsy

    Directory of Open Access Journals (Sweden)

    Nevzat Sener

    2014-02-01

    Full Text Available Aim:  In this study, we aimed to compare the outcomes of pathologic results of patients underwent transrectal prostate biopsy (TRIB with free/total PSA ratio. Material and Method: Patients having a PSA level between 2.5-10 ng/ml and underwent TRIB were retrospectively analyzed. Patients were divided into two groups as having a free/total PSA ratio below and over 20%. The ratio below 20% was in Group 1 and over 20% were in Group 2. Results: There were 60 patients in Group 1 and 82 patients in Group 2. PSA levels were 7,45 ± 2,14 and 6,31 ± 1,89 for groups 1 and 2, respectively (p=0.067. Fourteen patients in Group 1 (23% and 15 patients in Group 2 (18% were diagnosed with prostate cancer. Sensitivity was 100% and specificity was 23% when PSA level was between 2.5 and 10. Discussion: Free/Total PSA ratio can be applied to PSA levels between 2.5 and 10. Even though it has a low specificity, with high sensitivity, it can be used in urologic practice.

  6. Plantas cubanas con efecto antiinflamatorio

    Directory of Open Access Journals (Sweden)

    Ada Ivis Regalado Veloz

    Full Text Available La actividad antiinflamatoria suscita gran interés científico en el área farmacológica, debido a que muchas enfermedades en su evolución cursan por procesos inflamatorios (artritis reumatoide, ateroesclerosis, cáncer, diabetes, gota, asma, dermatitis, trastornos neurodegenerativos y diversas dolencias menores. Las enfermedades inflamatorias constituyen un problema de salud importante, debido a la falta de medicamentos eficaces y seguros para su uso por periodos prolongados. Hoy en día se trabaja en la búsqueda de alternativas de antiinflamatorios más seguros, en el que las plantas medicinales, una de las formas más antiguas de tratamiento, constituyen una elección a considerar. En este trabajo se realizó una revisión bibliográfica, sobre especies de plantas que crecen en Cuba que le reportan propiedades farmacológicas como antinflamatorios. En la revisión de la literatura se utilizó la base de datos Medline (vía PubMed, así como revistas nacionales desde el periodo de 2000 hasta el presente, con las palabras claves "inflamación" y "plantas cubanas antiinflamatorias" o "actividad antiinflamatoria" y "plantas medicinales".

  7. Evolución clínica y radiológica de una mujer con histiocitosis pulmonar de células de Langerhans durante 18 años Clinical and radiological evolution of a woman with pulmonary Langerhans cell histiocytosis during 18 years

    Directory of Open Access Journals (Sweden)

    XIMENA CEA B

    2008-01-01

    Full Text Available La histiocitosis pulmonar de células de Langerhans (HPCL es una enfermedad pulmonar difusa quística poco frecuente. En esta revisión, presentamos un caso de HPCL diagnosticada en una adolescente, no fumadora, que consultó por disnea rápidamente progresiva asociada a dolor pleurítico izquierdo, debido a un neumotorax bilateral. El diagnóstico se confirmó por biopsia quirúrgica. Se indicó tratamiento con corticoides (prednisona durante el primer año. Tras 18 años de seguimiento destaca una importante mejoría clínica, con una evolución radiológica y espirométrica favorable, pero no completa. Los casos que se presentan con neumotorax espontáneo recurrente son raros. La evolución natural de esta enfermedad es variable y su tratamiento aún es controversial, siendo la terapia con inmunosupresores, tal como corticoesteroides y agentes citotóxicos de valor limitado, ya que son escasos los estudios que avalan su eficaciaThe Pulmonary Langerhans cell histiocytosis (PLCH is an uncommon pulmonary diffuse cystic disease. This review presents one case of PLCH diagnosed in a non-smoker female adolescent, who consulted for rapidly progressive dyspnea associated to left pleuritic pain that corresponded to a bilateral pneumothorax. The diagnosis was confirmed by surgical biopsy of the lung. Treatment with corticoids (prednisone was indicated during the first year. After 18 years from diagnosis she presented an important clinical improvement, with a favourable but not complete radiological and spirometric improvement. The cases that make their debut with recurrent spontaneous pneumothorax are infrequent. The natural evolution of this disease is variable and the treatment is still controversial, been the immunosuppressive therapy, as corticoesteroids and cytotoxic agents of limited value, since are few studies that confirm their effectiveness

  8. La atencion a los padres con hijos con necesidades educativas especiales

    National Research Council Canada - National Science Library

    Pernas Pico, Claudia Maria

    2011-01-01

    Los padres que tienen hijos con necesidades educativas especiales (NEE) necesitan al igual que sus hijos de la intervencion del maestro de Audicion y Lenguaje con el objetivo primordial de mejorar la comunicacion y el lenguaje de los ninos...

  9. Bases tratadas con cemento, en California

    Directory of Open Access Journals (Sweden)

    Chinchilla, M.

    1962-05-01

    Full Text Available El uso de bases tratadas con cemento para autopistas se inició en el Estado de California en 1938, empleándose para carreteras con determinadas condiciones de tráfico. Inicialmente, se especificó el uso obligatorio de plantas mezcladoras para asegurar el debido control de las proporciones adecuadas.

  10. Arte con lenguaje matemático

    OpenAIRE

    Moratalla de la Hoz, Ascension; Sanz Garcia, Agripina

    2010-01-01

    En este artículo mostramos la experiencia realizada con alumnos de primer curso de la ETSA de la Universidad Politécnica de Madrid, basada en el análisis de obras arquitectónicas y de arte con lenguaje matemático

  11. Criptococoma pulmonar con invasión torácica en un varón inmunocompetente Pulmonary cryptococcoma with involvement of the chest wall in an immunocompetent patient

    Directory of Open Access Journals (Sweden)

    Ana A. Pisarevsky

    2010-04-01

    Full Text Available La criptococosis pulmonar en pacientes inmunocompetentes es una entidad poco habitual y su presentación como masas de gran tamaño, con compromiso de la pared torácica y de los tejidos blandos vecinos, no la encontramos descriptas en nuestra revisión bibliográfica. La variedad gattii (serotipoB/C está acotada geográficamente a regiones tropicales y subtropicales y parece afectar preferentemente a individuos inmunocompetentes. Presentamos el caso de un hombre de 51 años proveniente del noreste de la Argentina, fumador de 10 atados/año que consulta por aumento del volumen del hombro izquierdo e impotencia funcional por intenso dolor de seis meses de evolución. Mediante una biopsia percutánea de la masa, se diagnostica Cryptococcus neoformans, variedad gattii. El paciente recibe terapéutica antifúngica, mostrando una evolución favorable con disminución progresiva de la masa.The pulmonary cryptococcosis in immunocompetent patients is unusual, and its presentation as large masses with involvement of the chest wall and the neighboring soft tissues has not been found in our bibliographic research. The variety gattii (serotype B/C is limited geographically to tropical and subtropical regions and appears to affect particularly immunocompetent individuals. We describe the case of a 51-year-old man from the Northeast of Argentina, with a history of smoking 10 pack/year. He presented an increased volume of the left shoulder and reported that for the last six months he had been unable to move it due to the pain. A percutaneous biopsy of the mass provided a diagnosis of Cryptococcus neoformans, variety gattii. The patient was treated with antifungal therapy showing a favourable outcome with a progressive decrease of the mass.

  12. Utilidad de la videonasofibroscopía en el diagnóstico histológico del cáncer de laringe

    OpenAIRE

    Herrera J,María José; Urbano M,Hernán; Rahal E,Maritza

    2014-01-01

    Introducción: La laringoscopía directa (LD) se considera indispensable en el estudio del cáncer de laringe, tanto para precisar la extensión como para tomar biopsia. Objetivo: Demostrar que el resultado de biopsias tomadas por videonasofibroscopía (VFC) en cáncer de laringe es equivalente al de la biopsia definitiva. Material y método: Revisión de fichas de 53 pacientes del Servicio de Otorrinolaringología HBLT con sospecha de cáncer de laringe con biopsia realizada por VFC y definitiva, dura...

  13. Características fenotípicas de células T linfocitarias de tipo regulador (Treg presentes en el hígado de pacientes con infección crónica por VHB

    Directory of Open Access Journals (Sweden)

    Danely Velázquez

    2012-07-01

    Full Text Available El virus de la hepatitis B (VHB puede generar daños irreversibles en el hígado. En este trabajo se caracterizaron las poblaciones de células T reguladoras infiltrantes del hígado, en biopsias hepáticas de sujetos con infección crónica por el VHB. Se evidenció un incremento significativo (p< 0,05 del número de células T CD4+ que co-expresan FoxP3, IL-10 o TGFβ en los individuos infectados crónicos con el VHB, al compararse con los otros dos grupos estudiados. Este incremento se correlacionó positivamente con los niveles plasmáticos de ALT (R=0,9, p<0,05. No hubo diferencias significativas entre los tres grupos cuando se evaluó a las poblaciones CD8+. Estos resultados pudieran contribuir a entender los eventos que conducen al fracaso de la respuesta inmune, asociado a reclutamiento de poblaciones de tipo supresor, que pudieran inhibir la respuesta efectora específica contra el VHB contribuyendo con la persistencia viral. Palabras clave: Células T reguladoras, Higado, Hepatitis, Virus de la Hepatitis B, Inmunohistoquímica. Phenotypic characterization of regulatory T lymphocytes (Treg in livers from chronically HBV infected patients Abstract Hepatitis B virus (HBV is responsible for irreversible liver damage. In this study we evaluated regulatory T cell that infiltrate the liver in hepatic biopsies from subjects with chronic HBV infection. Data showed a significant increase (p <0.05 in the number of CD4 + T cells co-expressing FoxP3, IL-10 or TGFβ, in HBV chronically infected patients, as compared with the other group of patients. This increase was positively correlated with plasma ALT levels (R= 0.9, p <0.05. There were not significant differences between the clinical groups, when liver infiltrating CD8 + populations were evaluated. These findings may contribute to understand events leading to failure of the immune response associated with recruitment of suppressor-type populations, which could inhibit specific immune response

  14. Atrophy of the intestinal villi in a post-gastrectomy patient with severe iron deficiency anemia Atrofia de las vellosidades intestinales en un paciente postgastrectomizado con anemia ferropénica grave

    Directory of Open Access Journals (Sweden)

    A. Lizarraga

    2009-10-01

    Full Text Available Background & aims: Iron deficiency anemia is a common complication of gastric surgery that in certain patients can be refractory to treatment with oral iron and needs to be treated parenterally. Methods: A 48-year woman underwent gastric surgery for a gastric ulcer. She was referred to the nutrition unit for the study and treatment of a 3-year iron deficiency anemia refractory to oral iron supplementation. Blood tests, endoscopy and jejunal biopsy were made to study the case. Results: Intestinal villi atrophy in the absence of celiac disease was the result. She was treated with intravenous iron, resolving the villous atrophy and thus oral iron supplementation could be effective. Conclusion: This case illustrates that iron deficiency may cause villous atrophy. In this setting, parenteral iron administration is necessary to correct the haematological and non-hematological alterations associated with this deficiency.Introducción y objetivos: La anemia ferropénica es una complicación frecuente tras la cirugía gástrica que en algunos pacientes puede ser refractaria al tratamiento con hierro oral, siendo necesaria su administración por vía parenteral. Métodos: Presentamos el caso de una mujer de 48 años intervenida de gastrectomía para tratamiento de una úlcera gástrica. Fue remitida a la unidad de nutrición para estudio y tratamiento de una anemia ferropénica de 3 años de evolución refractaria al tratamiento con hierro oral. Para el estudio del caso se realizó analítica y endoscopia digestiva alta con biopsia yeyunal. Resultados: En el estudio realizado la paciente presentaba atrofia de la mucosa yeyunal en ausencia de enfermedad celíaca. Fue tratada con hierro intravenoso desapareciendo la atrofia intestinal, tras lo cual continuamos con suplementos de hierro por vía oral. Conclusión: Este caso ilustra que la deficiencia de hierro puede producir atrofia intestinal. Si esto ocurre, es necesario la suplementación de este metal

  15. Diagnosis of Helicobacter pylori infection in patients with bleeding ulcer disease: rapid urease test and histology Diagnóstico mediante endoscopia de la infección por Helicobacter pylori en pacientes con úlcera gastroduodenal y hemorragia digestiva: test rápido de ureasa e histología

    Directory of Open Access Journals (Sweden)

    M. Castro-Fernández

    2004-06-01

    controversias sobre el valor diagnóstico de practicar, en estos pacientes, alguna, ninguna o ambas pruebas diagnósticas. Objetivos: valorar los resultados del test rápido de ureasa y la histología, practicados simultáneamente, en el diagnóstico de infección por Helicobacter pylori (H. pylori en pacientes con úlcera gastroduodenal y hemorragia digestiva. Pacientes y métodos: incluimos 173 pacientes, 98 varones y 75 mujeres, edad media de 62 años (18-88, con hemorragia digestiva por úlcera duodenal (115 o gástrica (58, diagnosticados por endoscopia en las primeras 24 horas del ingreso. Ningún paciente había recibido tratamiento erradicador frente a H. pylori ni consumido inhibidores de la bomba de protones o antibióticos en al menos las dos semanas previas al ingreso. Investigamos la presencia de H. pylori mediante la obtención de dos biopsias antrales, para estudio histológico (hematoxilina-eosina y una o dos biopsias, también antrales, para el test rápido de ureasa. En los casos con test de ureasa e histología negativos se practicó test del aliento con urea marcada con 13C. Consideramos presencia de infección cuando al menos una de las pruebas invasivas o el test del aliento eran positivos y ausencia de infección cuando las dos pruebas invasivas y el test del aliento eran negativos. Resultados: ciento cincuenta y dos pacientes (88% presentaban infección por H. pylori, 104 (90% en el grupo con úlcera duodenal y 48 (83% en el grupo con úlcera gástrica. El test de ureasa resultó positivo en 119 casos (78% y la histología en 112 casos (74%. Con ambos métodos diagnosticamos 134 de los 152 casos (88% (p < 0,05. Ambos métodos fueron positivos en 97 casos y negativos en 39 casos. En 18 de estos 39 casos el test del aliento resultó positivo. Conclusiones: la histología y el test de ureasa tienen un valor diagnóstico similar en la detección de H. pylori en pacientes con úlcera gastroduodenal y hemorragia digestiva. El test de la ureasa, por la rapidez

  16. Paternidad: niños con discapacidad

    OpenAIRE

    Patricia Ortega Silva; Laura Evelia Torres Velázquez; Adriana Reyes Luna; Adriana Garrido Garduño

    2010-01-01

    La paternidad no sólo es un compromiso, una responsabilidad, algo que resulte difícil de realizar, sino que incluye, además, momentos de recreación, convivencia con el otro, expresión de sentimientos, etcétera, que llevan a establecer relaciones donde se va construyendo y reconstruyendo la identidad como persona tanto para el hombre como para el hijo o hija. En familias con hijos o hijas con discapacidad, se crea una fuerte tensión entre el ser y el deber ser; el varón empieza a cuestionarse ...

  17. Tratamiento conservador en pacientes con retinoblastoma bilateral

    Directory of Open Access Journals (Sweden)

    Juan C. Suárez

    2008-11-01

    Full Text Available OBJETIVO: comparar el tratamiento convencional del retinoblastoma bilateral, usado hasta hace algunos años, consistente en radioterapia o enucleación bilateral, con el tratamiento conservador actual que incluye termoterapia transpupilar (TTT o TTT/quimioterapia al menos en un ojo, en niños con diagnóstico de retinoblastoma bilateral. DISEÑO: estudio retrospectivo descriptivo. MUESTRA: 20 pacientes con diagnóstico de retinoblastoma bilateral que consultaron al Hospital Universitario San Vicente de Paúl, de Medellín, Colombia, entre 1997 y 2007. MÉTODO: se hizo enucleación del ojo con el tumor de mayor tamaño. En el otro ojo se hizo tratamiento con TTT, con el láser diodo (810 nm, spot amplio, solo o combinado con otras terapias. RESULTADOS: se dividió a los pacientes en dos grupos: 16 pacientes (32 ojos en el grupo 1 tratados conservadoramente y 4 pacientes (8 ojos en el grupo 2 con tratamiento convencional. El rango de edad fue de 1-72 meses en el grupo 1 y de 1-12 meses en el grupo 2. El tiempo de seguimiento fue de 7-67 meses para el grupo 1 y de 13-73 meses para el grupo 2. En el grupo 1 se hizo enucleación de 16 ojos (50%, radioterapia externa de uno (3,1%, quimioterapia más termoterapia de 5 (15,6% y quimioterapia más termoterapia más crioterapia de 10 (31,3%. En todos los pacientes se logró preservar al menos un ojo. En el grupo 2, se enuclearon 7 ojos (87,5% y se hizo radioterapia externa más enucleación en un paciente (12.5%. Además, todos los pacientes recibieron quimioterapia. CONCLUSIÓN: la terapia conservadora actual consistente en tratamiento local (termoterapia, crioterapia o braquiterapia y quimiorreducción permite preservar al menos un ojo y en algunos casos de los dos, muchas veces con buena agudeza visual, en niños con retinoblastoma bilateral; se evitan así la enucleación bilateral y la radioterapia externa usada en el tratamiento convencional con todos sus efectos secundarios. La enucleación contin

  18. El maltrato en las personas con discapacidad

    OpenAIRE

    Revuelta, Lucerga

    2014-01-01

    El maltrato no solo se realiza por acción sino también por omisión, la indiferencia hacia la persona con discapacidad es una forma de maltrato muy frecuente. Por ejemplo, ignorar y desatender las necesidades de la persona con discapacidad o, al contrario, la sobreprotección son maneras de maltrato. Cuando a un niño con discapacidad el padre o cuidador le hace todo, el niño se siente agredido pues le están incapacitando más de lo que su enfermedad ya lo hace.

  19. Posicionamiento WIFI con variaciones de fingerprint

    OpenAIRE

    Kornuta, Carlos; Acosta, Nelson; Toloza, Juan Manuel

    2013-01-01

    Los sistemas de posicionamiento Indoor estiman la posición de un dispositivo móvil en un entorno cerrado con una precisión relativa. Existen diversas técnicas de posicionamiento, donde el parámetro mayormente utilizado es el RSSI (Received Signal Strength Indicator). En este artículo se analiza la técnica Fingerprint con la finalidad de estimar el margen de error obtenido con la distancia euclidiana como métrica principal. Se presentan variantes de la construcción de la base de datos Fingerpr...

  20. Hipoacusia neurosensorial bilateral con implante coclear

    OpenAIRE

    Matallana Redondo, Noelia

    2015-01-01

    El presente trabajo se centra en el estudio de la discapacidad auditiva, específicamente en la hipoacusia neurosensorial bilateral con implantación coclear. Se propone una intervención individualizada que se desarrolla con un niño que presenta dicha afectación. El niño tiene 17 años de edad y tiene asociadas otras discapacidades. A través del planteamiento de objetivos y del manejo de recursos, estrategias de intervención y temporalización, se aplica la propuesta con el fin de tratar la co...

  1. El envejecimiento de las personas con discapacidad

    OpenAIRE

    Envejecimiento Activo, CERMI

    2012-01-01

    El envejecimiento activo es considerado como un concepto multidimensional que abarca y supera la buena salud, resultado de un amplio conjunto de factores biológicos, psicológicos y sociales. En el caso de las personas mayores con discapacidad, la ausencia de una política de promoción y sensibilización en la comunidad a veces les niega la igualdad de oportunidades en relación con el resto de los ciudadanos. Para desarrollar ese potencial de envejecimiento activo en personas con discapacidad ha...

  2. Materiales compuestos reforzados con estructuras MULTIAXIALES

    OpenAIRE

    Capdevila Juan, Francisco Javier; Ardanuy Raso, Mònica

    2011-01-01

    La combinación de los elementos estructurales de los tejidos de calada y los tejidos de malla conduce a una estructura híbrida. Esta estructura, que pueden incorporar varios hilos de trama o a la que se le puede insertar una tela no tejida, se denomina multiaxial. La combinación de las estructuras multiaxiales con resinas poliméricas permite obtener materiales compuestos con propiedades específicas y distintas a las de sus componentes - fibras y polímeros - para aplicaciones novedosas. Con es...

  3. Enfermedad coronaria en pacientes con psoriasis

    OpenAIRE

    Walter Masson; María L. Galimberti; Carolina L. Anselmi; Arturo Cagide; Ricardo L. Galimberti

    2013-01-01

    Comunicaciones previas asociaron la psoriasis con la enfermedad coronaria. Desconocemos si en nuestro país o región existe dicha asociación. Se realizó un estudio transversal analizando los datos de la historia clínica electrónica de un sistema de salud de Buenos Aires. Analizamos todos los pacientes mayores de 18 años con diagnóstico de psoriasis entre el 1 de enero de 2003 y el 31 de julio de 2011 y los comparamos con un grupo control, en una relación 2:1, obtenido en forma aleatoria del mi...

  4. Entornos adaptados para personas con discapacidad mental

    OpenAIRE

    Guasch Murillo, Daniel; Bonasa Jiménez, Mª del Pilar; López Novella, Judit; Mayor Sánchez, Carolina; Guasch Murillo, Yolanda

    2001-01-01

    Las universidades tienen ante sí un reto importante en conseguir entornos accesibles para el alumnado con discapacidad mental donde puedan desarrollar con éxito sus estudios universitarios y, de esta forma, mejorar sus perspectivas laborales. Sólo el 5,4% de las personas con discapacidad de 25 o más años tienen estudios universitarios o equivalentes, siendo este porcentaje del 18,7% en el caso de las personas sin discapacidad (Observatorio Estatal de la Discapacidad, 2010). Si se observa el p...

  5. MANEJO DE LA EMBARAZADA CON TROMBOFILIA HEREDITARIA

    OpenAIRE

    Hasbún H,Jorge; Conte L.,Guillermo

    2003-01-01

    El propósito del estudio es la detección de trombofilia hereditaria en pacientes con antecedente de trombosis y la evaluación de la profilaxis secundaria con Heparina de bajo peso molecular en el embarazo siguiente, en un diseño observacional prospectivo. Pacientes y Método. En once pacientes con Trombosis reciente se investigó Trombofilias: Antitrombina III, Proteína C, Proteina S, Factor V Leiden (Resistencia a la proteina C activada), Hiperhomocisteinemia (Mutación de la metiltetrahidrofol...

  6. Hiperalgesia asociada al tratamiento con opioides

    OpenAIRE

    Gil Martín, A.; M. Moreno García; J. Sánchez-Rubio Ferrández; T. Molina García

    2014-01-01

    La hiperalgesia inducida por opioides es una reacción paradójica caracterizada por una percepción intensificada de dolor relacionada con el uso de estos medicamentos en ausencia de progresión de la enfermedad o de síndrome de retirada. A diferencia de los casos de tolerancia, definida como pérdida de potencia analgésica durante el uso prolongado de opioides, no se produce mejoría con el escalado de dosis. La hiperalgesia inducida por opioides se ha manifestado en pacientes con dosis de manten...

  7. Study on infertility follicular ultrasound score from transrectal color Doppler ultrasound%腔内彩色多普勒超声对不孕症患者卵泡超声评分的研究

    Institute of Scientific and Technical Information of China (English)

    王文荣; 王艳娟; 刘瑞明; 张云; 孟凡艳

    2014-01-01

    目的:利用腔内彩色多普勒超声技术对不孕症患者卵泡监测并进行超声评分,初步探讨卵泡各种因素在不孕症范畴的相关性。方法对2011年1月至2013年12月我院超声诊断科就诊的不孕症患者腔内彩色多普勒超声所做的卵泡资料,通过卵泡大小、张力、被膜厚度、内部透声、血流情况等几个方面对卵泡进行评分并分级。结果卵泡大小界限17~25 mm计0分,14~17 mm及25~27 mm计1分,小于14 mm及大于27 mm计2分;张力分为3级,计0、1、2分;透声分为3级,计0、1、2分;被膜厚度,分为3级,小于0.5 mm,0.5~1.0 mm,大于1.0 mm计为0、1、2分;血流情况,阻力范围分为3级,计0、1、2分。结论腔内彩色多普勒超声对不孕症患者卵泡的超声评分简便易行,能够全面反映卵泡情况,给临床医生提供卵泡最全面的资料,为临床医师进一步诊治提供有力依据。%Objective To use transrectal color Doppler ultrasound in monitoring follicle infertility and ultrasound score , a preliminary study on the relationship between various factors in infertility categories of follicles.Follicular cavity data color Doppler ultrasound infertility patients .Methods On 2011 February to 2013 December in our hospital ultrasound department , by follicle size, tension, film thickness, the internal through several sound, blood flow and other aspects of scoring and grading of follicle .Results Follicle size limit of 17~25mm 0, 14 ~17mm and 25 ~27mm with 1 points, less than 14mm and greater than 27mm 2; tension was divided into 3, 0, 1, 2; sound transmission was divided into 3, 0, 1, 2; film thickness, was divided into 3 levels, less than 0.5mm, 0.5~1.0mm, more than 1.0mm is 0, 1, 2;blood flow, resistance range was divided into 3, 0, 1, 2.Conclusions Transrectal color Doppler ultrasound on follicular infertility score is simple , which can reflect the presence of follicle , follicle to

  8. 影响二次经直肠前列腺穿刺活检阳性率的因素分析%To investigate the factors on affectting the positive prostate cancer in the secondary transrectal prostate biopsy

    Institute of Scientific and Technical Information of China (English)

    曾健文; 蒋重和; 莫鉴锋; 周理林; 潘楚灶; 贺沂; 邵琳

    2015-01-01

    Objectives To Explore postive factors on suspicous prostate cancer in the secondary transrectal prostate biopsy.Methods From January 2008-February 2014,55 cases in our hospital had been recevied transrectal secondary prostate biopsy,retrospectively.According to the results of biopsy,the patients were divided into control groups and prostate cancer group.Differences between prostate-specific antigen(PSA) parameters and pathological findings were compared during the first puncture and to analyze the influenced factors in the second biopsy.Results There was significant difference in Family history of prostate cancer,prostate-specific antigen velocity (PSAV),prostate specific antigen density (PSAD),HGPIN,ASAP,chronic prostatitis between two groups (P < 0.05).Family history,PSAV,PSAD,HGPIN,ASAP were risk factorsn in secondary needle prostate biopsy.Results There was significant difference in Family history of prostate cancer,prostate-specific antigen velocity (PSAV),prostate specific antigen density(PSAD),HGPIN,ASAP,chronic prostatitis between two groups(P < 0.05).Family history,PSAV,PSAD,HGPIN,ASAP were risk factorsn in secondary needle prostate biopsy.Conclusions To avoid misdiagnosis and unnecessary repeat biopies,combined with the patient's family history,the first biopsy pathology results (HGPIN,ASAP) and PSAV,PSAD parameters can improve the positive rate of secondary prostate biopsy.%目的 探讨在二次经直肠前列腺穿刺活检中影响阳性率的因素.方法 回顾性分析2008年1月~2014年2月本院55例首次经直肠前列腺穿刺活检阴性并行二次经直肠前列腺穿刺活检的患者临床资料,依第二次穿刺活检结果分为前列腺癌组与非前列腺癌组.比较两组前列腺特异性抗原(PSA)相关参数及首次穿刺时病理结果的差异,并分析影响第二次穿刺活检阳性率的相关因素.结果 前列腺癌组家族史、前列腺特异性抗原速率(PSAV)、前列腺特异性抗原密度(PSAD)水平

  9. Single-fraction high-dose-rate brachytherapy using real-time transrectal ultrasound based planning in combination with external beam radiotherapy for prostate cancer: dosimetrics and early clinical results

    Science.gov (United States)

    Lauche, Olivier; Delouya, Guila; Taussky, Daniel; Menard, Cynthia; Béliveau-Nadeau, Dominic; Hervieux, Yannick; Larouche, Renée

    2016-01-01

    Purpose To validate the feasibility of a single-fraction high-dose-rate brachytherapy (HDRBT) boost for prostate cancer using real-time transrectal ultrasound (TRUS) based planning. Material and methods From August 2012 to September 2015, 126 patients underwent a single-fraction HDRBT boost of 15 Gy using real-time TRUS based planning. External beam radiation therapy (EBRT) (37.5 Gy/15 fractions, 44 Gy/22 fractions, or 45 Gy/25 fractions) was performed before (31%) or after (69%) HDRBT boost. Genito-urinary (GU) and gastro-intestinal (GI) toxicity were assessed 4 and 12 months after the end of combined treatment using the international prostate symptom score scale (IPSS) and the common terminology criteria for adverse events (CTCAE) v3.0. Results All dose-planning objectives were achieved in 90% of patients. Prostate D90 ≥ 105% and ≤ 115% was achieved in 99% of patients, prostate V150 ≤ 40% in 99%, prostate V200 < 11% in 96%, urethra D10 < 120% for 99%, urethra V125 = 0% in 100%, and rectal V75 < 1 cc in 93% of patients. Median IPSS score was 4 at baseline and did not change at 4 and 12 months after combined treatment. No patients developed ≥ grade 2 GI toxicity. With a median follow-up of 10 months, only two patients experienced biochemical failure. Among patients who didn't receive ADT, cumulative percentage of patients with PSA ≤ 1 ng/ml at 4 and 18 months was respectively 23% and 66%. Conclusions Single-fraction HDRBT boost of 15 Gy using real-time TRUS based planning achieves consistently high dosimetry quality. In combination with EBRT, toxicity outcomes appear promising. A longer follow-up is needed to assess long-term outcome and toxicities. PMID:27257413

  10. 经直肠双平面腔内超声对肛瘘及其分型的诊断价值%Biplane Transrectal Sonography Diagnosis of Fistula in Ano

    Institute of Scientific and Technical Information of China (English)

    吴长君; 吴国柱; 刘银龙; 王俊峰; 张光晨; 张锋; 汪勇

    2011-01-01

    目的 探讨应用经直肠双平面腔内超声诊断肛瘘及其分型的临床价值.方法 应用经直肠双平面腔内超声诊断79例肛痿,该组病例均经手术证实,超声诊断与术后结果 对照.结果 经直肠超声对肛瘘分型诊断符合率为92.4%,对内口的诊断符合率为92.1%,对主瘘管的诊断符合率为97.5%,对支管的诊断符合率为73.1%.结论经直肠双平面腔内超声能准确诊断肛瘘并正确分型,为临床诊断及术式的选择提供准确可靠的信息.%Objective To explore typing of anal fistula and diagnostic value of Dual plane TRUS(transrectal Ultrasonograpy)in anal fistula. Methods The sonographic features of seventy-nine patients of fistula in ano had been studied. All were treated with operation and approved by pathologic diagnosis, the ultrasonic types were classified according to the features of sonographic characteristics and the accuracy of TRUS were compared with surgical findings. Results The diagnose accordance rate of ultrasonic types was 92. 4%. The diagnose accordance rate of internal opening, primary tube and branch tube was 92.1% ,97. 5% and 73.1% respectively. Conclusions The types of anal fistula could be diagnosised exactly by Dual plane TRUS,Dual plane TRUS also could offer precise diagnostic information for the choice of the clinical treatment.

  11. Utilidad de los diferentes métodos no invasivos de predicción de fibrosis hepática en pacientes del País Vasco con hemocromatosis fenotípica Utility of various non-invasive methods for fibrosis prediction among Basque Country patients with phenotypic hemochromatosis

    Directory of Open Access Journals (Sweden)

    A. Castiella

    2008-10-01

    Full Text Available Objetivo: determinar si el producto de la edad por la concentración de hierro hepático (índice de fibrosis y los valores de plaquetas, ferritina y transaminasas están relacionados con el riesgo de padecer fibrosis avanzada (F ≥ 3 en hemocromatosis. Métodos: estudio retrospectivo de 32 pacientes con hemocromatosis hereditaria con expresión fenotípica. Todos los pacientes fueron biopsiados obteniéndose la concentración de hierro hepático. Resultados: en 7 pacientes se realizó RM (1,5T con obtención de concentración de hierro hepático (protocolo de Alustiza. Biopsia hepática: en 23 pacientes fibrosis 0-2; en 9 fibrosis 3-4. El índice de fibrosis mostró una especificidad del 68%, sensibilidad del 85,7%, VPP del 42,8% y VPN del 94,4% para fibrosis avanzada. La cifra de plaquetas ( 1.000 VPN 75% y el índice de fibrosis por RMN (punto corte 480.000 VPN 80%. La combinación de los mismos, el índice de fibrosis (por biopsia o por RM con las transaminasas y las plaquetas con las transaminasas, reveló un VPN del 100%. Conclusiones: el índice de fibrosis (> 480.000 y las plaquetas (Objective: to determine whether the product of multiplying age by liver iron concentration (LIC (fibrosis index; cut-off, 480,000, platelets, transaminases, and ferritin values are related to the risk of high grade fibrosis. Methods: a retrospective study of 32 patients with hereditary hemochromatosis (HH with phenotypic expression. All patients had a liver biopsy with LIC. Results: in 7 patients a magnetic resonance imaging (MRI scan (1.5 T was obtained with LIC following Alustiza's protocol. Liver biopsy: fibrosis grade (F 0-2 in 23 patients; F 3-4 in 9. Fibrosis index (FI showed a specificity of 68%, sensitivity of 85.7%, positive predictive value (PPV of 42.8%, and negative predictive value (NPV of 94.4% for high-grade fibrosis. Platelet count ( 1,000 a NPV of 75%, and MRI-derived LIC x age (> 480,000 a NPV of 80%. The combination of FI (either by

  12. Desensibilización con aspirina en un paciente con intolerancia a antiinflamatorios no esteroides

    Directory of Open Access Journals (Sweden)

    Mirta Álvarez Castelló

    2011-12-01

    Full Text Available El ácido acetilsalicílico o aspirina es uno de los medicamentos más utilizados a nivel mundial. Los pacientes con enfermedad coronaria requieren tratamientos prolongados con este medicamento, el cual se les niega a aquellos con historias de reacciones adversas a este. Se recoge en la literatura internacional el uso de terapias de desensibilización en pacientes con intolerancia a los antiinflamatorios no esteroides con diferentes protocolos, con resultados satisfactorios. En este trabajo se describe la primera desensibilización con aspirina realizada a un paciente en el Hospital Universitario «Calixto García» y el protocolo de actuación utilizado. No se encontró otro caso en la bibliografía nacional. El paciente actualmente ingiere 125 mg diarios sin reacciones adversas. Se considera que la desensibilización con aspirina es una opción terapéutica efectiva en aquellos pacientes con intolerancia a esta y con una afección que justifique este proceder.

  13. 经直肠前列腺穿刺活检术后直肠活动性出血的临床分析%Reactive Proctorrhagia after Transrectal Prostate Biopsy

    Institute of Scientific and Technical Information of China (English)

    彭涛; 庄红雨; 许学敏

    2011-01-01

    目的 探讨影响经直肠前列腺穿刺活检术后直肠活动性出血并发症的相关因素,为提高诊治水平提供依据.方法 回顾性分析1 127例经直肠前列腺穿刺患者的年龄、前列腺体积、前列腺特异抗原(PSA)、穿刺活检前是否应用抗凝药、穿刺针数、病理结果.经直肠前列腺穿刺活检术后发生直肠活动性出血8例,分析活动性出血部位、程度、处理方法、治疗转归.结果 1 127例经直肠前列腺穿刺活检术后发生直肠活动性直肠出血8例,发生率为0.71%,其中997例前列腺增生患者发生直肠活动性出血5例,130例前列腺癌患者发生直肠活动性出血3例.8例直肠活动性出血患者中有2例前列腺平面以上直肠活动性出血点1个,出血量300~400 ml,直肠镜下缝扎一针止血成功;4例直肠前列腺部活动性出血点1个、2例前列腺外侧直肠活动性出血点1个,出血量100~200 ml,均在直肠镜下采用双极电凝(功率20 W)止血加肛管压迫止血成功.直肠活动性出血与直肠无活动性出血患者的年龄、前列腺体积、PSA水平比较,差异均无统计学意义(P>0.05).直肠活动性出血的影响因素分析显示,经直肠前列腺穿刺活检前是否口服抗凝药、穿刺针数均与术后直肠活动性出血无关,而患者前列腺疾病的性质与术后直肠活动性出血有关(P<0.05).结论 经直肠前列腺穿刺患者的年龄、前列腺体积、PSA、穿刺活检前是否应用抗凝药、穿刺针数与穿刺活检术后直肠活动性出血均无关,前列腺癌较前列腺增生患者易发生直肠活动性出血.正确处理术后直肠活动性出血就不会产生严重后果.%Objective To determine whether reactive proctorrhagia after transrectal prostate biopsy is affected by potential correlation factors and to improve our quality of diagnosis and treatment. Methods A total of 1 127 transrectal prostate biopsy cases were retrospectively evaluated

  14. 经直肠前列腺穿刺活检术并发感染性休克和MODS的临床研究%Clinical Analysis of Septic shock and MODS following transrectal ultrasound-guided prostate biopsy

    Institute of Scientific and Technical Information of China (English)

    唐普贤; 王建业; 刘明; 何清; 冯喆; 韦军民

    2012-01-01

    Objective To investigate the diagnosis and treatment of septic shock and multiple organ dysfunction syndrome (MODS) following transrectal ultrasound-guided prostate biopsy (TRUSPB). Methods We reported two cases,45 and 46 years old,of septic shock and MODS after TRUSPB from June 1996 to May 2011.10 cases like these two cases in literatures were acquired (3 cases in Chinese and 7 cases in English) from 1991 to 2011,and the causes of severe infections following transrectal prostate biopsy and its prophylactic procedures were discussed as well. Results The two cases,suffered postoperative septic shock and MODS 16 -40 h after being smoothly performed TRUSPB.One patient died four days after surgery and the other improved after five days antibiotic treatment.All the 12 cases had abrupt onsets and deteriorated rapidly,2 cases died and 1 case was performed amputation due to double lower limb gangrene,resulted in high mortality and morbidity.There are many risk factors,such as repeated puncture (4/12),diabetes (3/12),chronic infections (3/12) and used immune suppression (1/12),et al; blood culture was positive in 9 case and E.coli bacteria was the main bacteria(8/9),besides,half of them were multi-drug resistant (4/8) and other 2 cases were ESBLs ( + ) or 1 case was quinolone-resistant repectively.9 cases recovered after actively controlled infection using carbapenem and other treatment. Conclusions Transrectal ultrasound-guided prostate biopsy could cause serious complications such as septic shock,to which more attentions should be paid.Preoperative use of carbapenem should be recommended for patients with repeating biopsy or other risk factors.%目的 探讨B超引导下经直肠前列腺穿刺活检术(TRUSPB)并发感染性休克和多器官功能不全综合征(MODS)的诊断与治疗. 方法 1996年6月至2011年5月行TRUSPB并发感染性休克和MODS的患者2例,年龄分别为45、46岁,回顾2例患者的诊治经过,结合1991-2011年文献报道10

  15. Anticoncepcion en mujeres con lupus eritematoso sistemico

    National Research Council Canada - National Science Library

    Restrepo Escobar, Mauricio; Vasquez Duque, Gloria Maria; Gonzalez Naranjo, Luis Alonso

    2013-01-01

    .... Por el contrario, las mujeres con anticuerpos antifosfolipidos positivos presentan un alto riesgo de trombosis arterial y venosa y en consecuencia se debe evitar en ellas el uso de anticonceptivos...

  16. Últimas tardes con Teresa

    Directory of Open Access Journals (Sweden)

    Hugo Ruiz Rojas

    1966-08-01

    Full Text Available Ultimas tardes con Teresa, del escritor español Juan Marsé, viene a llamar la atención sobre este joven autor, que ya en sus libros anteriores, Esta cara de la luna y Encerrados con un solo juguete, había demostrado claras dotes de novelista, puesto que no solo tenía algo que decir sino que sabía también cómo decirlo.

  17. Vicente del Bosque: el carisma con mesura

    Directory of Open Access Journals (Sweden)

    Antonio Sánchez Pato

    2013-01-01

    Full Text Available La vida del seleccionador español de fútbol, D. Vicente del Bosque, constituye un ejemplo de dedicación al deporte rey. En este ensayo haremos una alabanza de los principales méritos deportivos, docentes y personales que atesora, con el objetivo de servir de laudatio1 con motivo de su investidura como doctor honoris causa por la Universidad Católica San Antonio de Murcia.

  18. Presa con revestimiento asfáltico

    Directory of Open Access Journals (Sweden)

    Proudfit, D. P.

    1960-07-01

    Full Text Available La presa denominada Montgomery se halla situada sobre el río South Platte River, a unos 8 km aguas arriba de la ciudad de Alma, del Estado de Colorado (EE. UU., y en la ladera oriental de la cordillera Continental Divide. El cuerpo o dique de esta presa está constituido por piedra, revestida con una capa de hormigón asfáltico en el paramento de contacto con el agua.

  19. John Ashbery: encuentro con los pintores

    OpenAIRE

    Power, K

    2009-01-01

    Este texto, basado en la ponencia presentada en el Seminario Permanente de Investigación de la Cátedra Félix Huarte dedicado a "Autorretrato en espejo convexo", propone un recorrido por el diálogo de Ashbery con la pintura: su primera etapa como crítico de arte en París y su relación con los pintores del expresionismo abstracto norteamericano.

  20. Infactibilidad en programas con restricciones lineales

    Directory of Open Access Journals (Sweden)

    Liern Carrión, V.

    1999-01-01

    Full Text Available En este trabajo resumimos las técnicas más habituales que permiten diagnosticar las causas de infactibilidad de programas con restricciones lineales. Además, presentamos dos métodos que, con las mínimas transformaciones posibles del modelo inicial, permiten hacer viable un programa infactible. Los métodos descritos son aplicados a un modelo de selección de carteras eficientes.