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Sample records for con asma grave

  1. Aptitud clínica ante el paciente pediátrico con asma grave en residentes de pediatría y urgencias

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    J. Loría-Castellanos

    Full Text Available Objetivo. Construir, validar y aplicar un instrumento para evaluar la aptitud clínica de los residentes de pediatría y urgencia ante los pacientes pediátricos con asma grave. Sujetos y métodos. Estudio observacional autorizado por el comité de investigación. El instrumento se construyó a través de cinco casos clínicos reales, validado por consenso de expertos en pediatría, urgencias e investigación educativa, obteniéndose una versión final de 150 ítems con una consistencia de 0,89. Se evaluaron 10 residentes de pediatría y 21 de urgencias. Se realizó un análisis estadístico no paramétrico. Resultados. La mayoría de los residentes (79,73% se ubicaron en los niveles bajos-muy bajos de aptitud clínica, ninguno alcanzó niveles superiores. Las pruebas estadísticas no encontraron diferencias entre los grados académicos o la especialidad. Conclusiones. El instrumento construido tiene una adecuada consistencia. El proceso educativo al que se han sometido estos residentes parece no favorecer el desarrollo de reflexión, lo que podría limitar su práctica profesional real.

  2. Factores de Risco da Asma Grave

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    N. Adel

    1999-07-01

    Full Text Available RESUMO: Apesar da rápida progressão do conhecimento da fisiopatologia da asma e da larga difusão de meios terapêuticos de eficácia acrescida, observase um aumento da morbalidade e da morbildade da asma em numerosos paises, em particular nos paises industrialtzados, por razões ainda pouco conhecidas Estes factos permitem questionar o funcionamento do sistema de cuidados de saúde e a difusão dos progressos terapêuticos na população asmática. Os autores definem o concetto de asma aguda grave, salientando dois tipos: o tipo 1, de «instalação progressiva» em algumas horas ou dtas eo upo 2 de «instalação brutal» em menos de três horas Os factores de risco para cada urn deles parecem ser diferentes.Os autores fazem uma revisão dos factores de risco da asma grave, tendo em conta as caracterisucas individuais do doente, os factores ambientats e a intervenção da sociedade.Em relação aos factores individuais como a idade e o sexo, verificase que na infância, as taxas de internarmento por asma são mais elevadas no sexo masculino, sendo no total de internamentos em todas as idades, mais elevadas no sexo feminino e em doentes com internamentos anteriores por asma. O aumento da mortalidade por asma atinge em particular os doentes jovens economicamente desfavorecidos, pela dificuldade no acesso aos cuidados de saúde e na compra dos medicamentos, por utilizarem com menor frequência os tratamentos de crise e de fundo. Os factores psicológicos podem predispor à morte por asma no adolescente, sendo relevantes a subvalo-rização e a negação da doença por parte do doente ou da família Verificase por outro lado, um aumento da prevalência da depressão e do desespero nas cnanças com asma grave. As reacçõs psicológicas face a acontecimentos negauvos, como a morte de um ente próximo, a perda de emprego, conflitos familiares, provocam maior

  3. Aptitud clínica ante el paciente pediátrico con asma grave en residentes de pediatría y urgencias Clinical skills at the pediatric patient with severe asthma of Pediatrics and Emergency residents

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    J. Loría-Castellanos

    2010-12-01

    Full Text Available Objetivo. Construir, validar y aplicar un instrumento para evaluar la aptitud clínica de los residentes de pediatría y urgencia ante los pacientes pediátricos con asma grave. Sujetos y métodos. Estudio observacional autorizado por el comité de investigación. El instrumento se construyó a través de cinco casos clínicos reales, validado por consenso de expertos en pediatría, urgencias e investigación educativa, obteniéndose una versión final de 150 ítems con una consistencia de 0,89. Se evaluaron 10 residentes de pediatría y 21 de urgencias. Se realizó un análisis estadístico no paramétrico. Resultados. La mayoría de los residentes (79,73% se ubicaron en los niveles bajos-muy bajos de aptitud clínica, ninguno alcanzó niveles superiores. Las pruebas estadísticas no encontraron diferencias entre los grados académicos o la especialidad. Conclusiones. El instrumento construido tiene una adecuada consistencia. El proceso educativo al que se han sometido estos residentes parece no favorecer el desarrollo de reflexión, lo que podría limitar su práctica profesional real.Aim. To develop, validate and implement a tool to assess the clinical competence of pediatric residents and medical emergencies to pediatric patients with severe asthma. Subjects and methods. An observational study approved by the research committee. The instrument was built through five problematized clinical cases, validated by consensus by experts in pediatrics, emergency and educational research, obtaining a final version of 150 items with a consistency of 0.89. It evaluated 10 pediatric residents and 21 of emergency. We performed a nonparametric statistical analysis. Results. Most residents (79.73% were located in low-very low levels of clinical competence, none reached higher levels. Statistical tests found no differences between academic degrees or specialty. Conclusions. The educational process that these students have had seems to favor the development

  4. Conocimientos y modos de actuación de la familia en escolares con asma bronquial

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    Zoraya Coro Carrasco

    2013-08-01

    Full Text Available Introducción: en el manejo del asma bronquial es fundamental lograr el control de la enfermedad de manera tal que el paciente y su familia alcance su calidad de vida diaria, siendo la educación un pilar esencial en tal propósito. Objetivo: evaluar la influencia de la familia en la severidad del asma bronquial en escolares clasificados como severos persistentes. Material y método: se realizó una investigación explicativa, observacional, de caso-control, transversal en el área de salud Pedro Borras del municipio Pinar del Río entre enero de 2007 y julio de 2008. El universo y muestra estuvo constituido por asmáticos en edad escolar, incluyéndose en el grupo estudio 26 pacientes con asma bronquial severa persistente y en el grupo control igual cantidad con asma bronquial no severa persistente. Resultados: en el grupo de pacientes con asma severa persistente el 92% no poseían conocimientos suficientes al asma bronquial; el 88.8 % no cumplían con las medidas de control ambiental; el 50 % incumplían el tratamiento intercrisis y el 76.9 % realizaban la técnica inhalatoria de manera incorrecta. Conclusiones: los conocimientos insuficientes en relación al asma bronquial estuvieron asociados a las evoluciones más tórpidas de la enfermedad, constatándose además una relación de dependencia entre la severidad de enfermedad y los modos de actuación de la familia en cuanto a: cumplimiento de las medidas de control ambiental, cumplimiento del tratamiento farmacológico preventivo de las crisis y realización de la técnica inhalatoria. (p< 0,05.

  5. O mundo da criança portadora de asma grave na escola El mundo del niño portador de asma grave en la escuela Daily life of children with acute asthma in school settings

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    Regina Issuzu Hirooka de Borba

    2009-01-01

    Full Text Available OBJETIVO: Compreender o significado que a criança asmática grave e sua família atribuem à doença e suas implicações na escola. MÉTODOS: Estudo de caso qualitativo, desenvolvido no ambulatório de pediatria de um hospital do Município de São Paulo. Foram estudadas três crianças e seus familiares, utilizando observação participante, entrevista e brinquedo terapêutico dramático. RESULTADOS: As demandas do tratamento e as freqüentes crises de asma influenciaram no cotidiano da criança na escola como: falta às aulas; deixar de aprender; restrinção nas brincadeiras e relacionamento conflituoso com colegas. CONSIDERAÇÕES FINAIS: Tendo em vista as dificuldades encontradas pelas crianças em freqüentar a escola e conviver com os colegas, recomenda-se um trabalho conjunto entre os profissionais de saúde e da educação, assegurando a manutenção da educação formal e do convívio social salutar.OBJETIVO: Comprender el significado que el niño asmático grave y su familia atribuyen a la enfermedad y sus implicancias en la escuela. MÉTODOS: Se trata de un estudio de caso cualitativo, desarrollado en el consultorio externo de pediatría de un hospital del Municipio de Sao Paulo. Fueron estudiados tres niños y sus familiares, utilizando la observación participante, entrevista y juego terapéutico dramático. RESULTADOS: Las demandas del tratamiento y las frecuentes crisis de asma influenciaron en el cotidiano del niño en la escuela como: falta a las clases; dejar de aprender; restricción en los juegos y relación conflictiva con sus colegas. CONSIDERACIONES FINALES: Teniendo en vista las dificultades encontradas por los niños para frecuentar a la escuela y convivir con sus colegas, se recomineda un trabajo conjunto entre los profesionales de salud y de educación, asegurando la manutención de la educación formal y de la convivencia social saludable.OBJECTIVES: To understand the meaning of asthma and its implications in daily

  6. Fenótipos clínicos de asma grave Clinical phenotypes of severe asthma

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    Roseliane de Souza Araújo Alves

    2008-09-01

    Full Text Available OBJETIVO: Estabelecer os fenótipos clínicos em portadores de asma grave. MÉTODOS: Foram estudados, retrospectivamente, 111 pacientes em um ambulatório especializado. Os pacientes foram avaliados e acompanhados de maneira sistemática, estabelecendo-se ao final do acompanhamento a adesão e o controle ou não da doença por dados clínicos e funcionais. A resistência ao tratamento foi definida como o não preenchimento, ao final do acompanhamento, por pelo menos seis meses, dos critérios de controle de asma, apesar do uso correto e adesão à medicação. Os fenótipos foram determinados por análise fatorial e comparados por testes diversos. RESULTADOS: Ao final, 88 pacientes foram considerados aderentes e 23 não aderentes. Por análise fatorial do grupo aderente, quatro fenótipos foram determinados: o fenótipo 1 (28 pacientes, formado pelos pacientes resistentes ao tratamento, com maior freqüência de sintomas noturnos, maior número de exacerbações e uso mais freqüente de broncodilatador de resgate; o fenótipo 2 (48 pacientes, formado pelos pacientes com obstrução persistente, com menores valores de relação volume expiratório forçado no primeiro segundo/capacidade vital forçada na avaliação inicial, idade mais avançada e maior tempo de doença; o fenótipo 3 (42 pacientes, representa os pacientes com rinossinusite alérgica, sendo constituído de não fumantes com obstrução predominantemente reversível; e o fenótipo 4 (15 pacientes, formado por casos com história de intolerância à aspirina associado à asma quase fatal. CONCLUSÕES: Um número significativo de portadores de ama grave não adere ao tratamento. Muitos pacientes com asma grave têm obstrução irreversível, mas o fenótipo clínico mais relevante é constituído pelos pacientes resistentes ao tratamento habitual.OBJECTIVE: To characterize clinical phenotypes of severe asthma. METHODS: A total of 111 patients were retrospectively evaluated at a

  7. La Auriculopuntura con semillas en el tratamiento del asma bronquial en edad pediátrica

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    Tamara Hervis Lee

    1999-01-01

    Full Text Available Se realizó un estudio descriptivo investigativo en el Policlínico Docente "19 de Abril" durante el año 1996 en el que se incluyó a 97 niños portadores de asma bronquial, cuyas edades oscilaban entre 1 y 14 años. Fueron tratados con auriculopuntura usando el método de pega y presión, con semillas Wang Bu Liu Xin, desarrollado por la escuela de la profesora Huan Li Chung. Se obtuvo una disminución del uso de medicamentos durante la crisis y la intercrisis, así como del número de pacientes clasificados como asmáticos severos y moderados; incrementándose por ende el total de pacientes con asma ligera.A descriptive and investigative study was conducted at the "19 de Abril" Teaching Polyclinic during 1996. 97 children carriers of bronchial asthma, who were between 1 and 14 years old, were treated with auriculopuncture by the method of sticking and pressuring with Wang Bu Liu Xin seeds, a method that is developed by the school of professor Huan Li Chung. It was possible to reduce the use of drugs during the crises and intercrises, as well as the number of patients classified as severe and moderate asthmatic patients. As a result, there was an increase of patients with mild asthma.

  8. Impacto da atenção farmacêutica na função pulmonar de pacientes com asma grave

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    Fernando Zanghelini

    2013-08-01

    Full Text Available O estudo avaliou a influência do serviço de Atenção Farmacêutica na otimização dos resultados terapêuticos de pacientes com asma grave não controlada, em uso de formoterol associado à budesonida. Utilizou-se o Método Dáder de Seguimento Farmacoterapêutico e o Teste do Controle de Asma (ACT™ para avaliação de resultados, assim como a espirometria. Foram acompanhados 26 pacientes por um período não inferior a seis meses, cuja média de idade foi 55 ± 11 anos, destes, 22 (84% foram do gênero feminino. Na pesquisa verificou-se que 22 (84,6% pacientes apresentaram mais de uma enfermidade associada à asma grave e 24 (92% faziam uso de dois ou mais fármacos. Foram detectados 58 resultados negativos associados aos medicamentos (RNM, com incidência de 2,2 ± 0,99 RNM por usuário. O RNM mais frequente foi insegurança não quantitativa identificada em 11 usuários (43%, sendo 31% desses devido às reações adversas ao medicamento. Foram realizadas 65 intervenções farmacêuticas para resolver os RNM, com média de 2,5 ± 1,2 por paciente, das quais 85% ocorreram na farmácia sem a necessidade de voltar ao médico. Dos resultados clínicos, após as intervenções farmacêuticas, todos os usuários tiveram melhora significativa da asma (p<0,05, porém 2 deles (7,6% ainda apresentaram asma não controlada. Assim, o estudo sinalizou a necessidade do acompanhamento farmacoterapêutico aos usuários com asma grave não controlada para otimização dos resultados clínicos.

  9. Uso do sulfato de magnésio venoso para tratamento da asma aguda grave da criança no pronto-socorro

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    Tânia Mara Baraky Bittar

    2012-03-01

    Full Text Available A asma aguda grave é uma emergência médica que deve ser diagnosticada e tratada rapidamente. O tratamento inicial inclui broncodilatadores e corticosteróides sistêmicos. Em casos graves, com fraca resposta ao tratamento padrão, o sulfato de magnésio venoso surge como opção terapêutica. O objetivo deste artigo foi revisar a literatura sobre o uso do sulfato de magnésio venoso na asma aguda em crianças no pronto-socorro no que se refere a eficácia, indicação, dosagem, efeitos adversos e contraindicações. Realizada revisão narrativa por meio das Bases de dados Medline, Lilacs e Cochrane Database of Systmatic Reviews, entre 2000 e 2010. Utilizados os descritores: asthma, children, emergency, magnesium sulfate. Incluídos oito ensaios clínicos controlados, três meta-análises, um estudo retrospectivo, oito artigos de revisão e um estudo transversal. A eficácia do magnésio venoso em crianças foi observada por vários autores, com raros efeitos adversos. Seu uso foi indicado para os pacientes com asma aguda moderada e grave que não responderam ao tratamento inicial com broncodilatador e corticosteróide. As contraindicações em pediatria são poucas. Entre elas estão insuficiência renal e bloqueio atrioventricular. Existem poucos relatos da interação do magnésio com drogas de uso pediátrico. Apesar da segurança, na prática, o magnésio venoso é pouco usado na asma aguda em pediatria. Na maioria das vezes, é indicado tardiamente para impedir falência respiratória e internação na unidade de cuidados intensivos. Os estudos demonstram que o magnésio venoso é uma droga eficaz e segura na criança com asma aguda grave, porém o seu uso no pronto-socorro ainda é limitado.

  10. Quais os parâmetros funcionais que permitem diferenciar asma grave de DPOC?

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    Ricardo Marques Dias

    2010-03-01

    Full Text Available Resumo: Com o objectivo de identificar parâmetros funcionais respiratórios que contribuam para o diagnóstico diferencial entre asma e DPOC, estudámos 20 asmáticos e 30 bronquíticos, com ou sem enfisema, com os exames usuais de função pulmonar: espirografia, pletismografia e DLCO, pré e pós-broncodilatação para os dois primeiros exames. Os grupos apresentam diferenças significativas na sua constituição. Os asmáticos são mais jovens, média de 48 anos, contra 59 anos no grupo com DPOC, e o grupo é constituído predominantemente por mulheres, 65% contra 40%, respectivamente. Os exames funcionais pulmonares, realizados conforme as directrizes internacionais, mostram, pela espirografia, que os asmáticos têm obstrução mais intensa, VEF1/CVF de 59 versus 66 e maior resposta broncodilatadora pelo VEF1, quer em valor absoluto, quer por variação percentual, do basal (% ou do valor previsto (%P. A DLCO mostra-se, em média, normal entre os asmáticos, 103%P, e diminuída no grupo com DPOC, 69%P. Na pletismografia constatámos que os asmáticos têm maior volume residual (%P e resistência de vias aéreas. Concluímos que vários parâmetros funcionais diferenciam a asma da DPOC, como um grupo; na análise individual, a DLCO é o parâmetro que melhor discrimina as duas doenças, possuindo maior especificidade para o diagnóstico de DPOC, seguida pelas variações de VEF1 na broncodilatação, com maior sensibilidade para o diagnóstico de asma. Desta forma, estes dois exames são destaque no diagnóstico diferencial das doenças obstrutivas.Rev Port Pneumol 2010; XVI (2: 253-272 Abstract: The aim of this study was to identify the respiratory function parameters that help in the accurate diagnosis of asthma and COPD. We studied 20 asthma and 30 COPD patients who underwent lung function tests including spirometry and plethysmography

  11. Factores peri y postnatales relacionados con el asma bronquial en niños

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    Odalys Orraca Castillo

    2014-06-01

    Full Text Available Introducción: el asma es una de las enfermedades que recuerda a los médicos la importancia de los elementos clínicos y epidemiológicos en el reconocimiento del paciente. La enfermedad surge por factores genéticos y ambientales. Objetivo: describir los factores peri y postnatales del asma bronquial en pacientes de edad pediátrica en Pinar del Río. Material y método: se realizó un estudio descriptivo en la provincia Pinar del Río durante el periodo enero-junio 2010. Fueron seleccionados 585 asmáticos de edad pediátrica, por muestreo probabilístico estratificado, proporcional al universo de pacientes de las capitales municipales. Se consideró a cada municipio como estrato. Se usó la técnica de muestreo sistemático. Se calcularon las frecuencias absolutas y relativas de las variables cualitativas estudiadas. Resultados: el 10.8% de las madres fueron fumadoras durante el embarazo. El 6.7% y 39.5% de los niños fueron fumadores activos y pasivos respectivamente. El 34.2% de los niños asmáticos no mantuvo lactancia materna exclusiva hasta los tres meses. La rinitis ocupó el primer lugar (55% dentro de las co-morbilidades alérgicas. El 73.2% de los pacientes presentaron catarros, seguido de las amigdalitis e infecciones parasitarias. Conclusiones: el tabaquismo (pasivo y activo, la convivencia con animales domésticos, el consumo excesivo y temprano de leche de vaca con el retiro temprano de la lactancia materna exclusiva y las infecciones respiratorias como antecedentes patológicos personales constituyen factores peri y postnatales relacionados con niños asmáticos en Pinar del Río en quienes la rinitis y dermatitis se asociaron como parte de la marcha atópica.

  12. Agranulocitosis inducida por metimazol en pacientes con enfermedad de Graves

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    Helard Manrique-Hurtado

    2013-04-01

    Full Text Available Objetivo: Describir las características clínicas y epidemiológicas de los pacientes con enfermedad de Graves que presentaron agranulocitosis inducida por metimazol. Material y métodos: Estudio retrospectivo, tipo serie de casos. Se revisaron las historias clínicas de todos los pacientes con diagnóstico de agranulocitosis inducida por metimazol, atendidos en el Hospital Nacional Arzobispo Loayza, entre enero 2002 y diciembre 2008. Se buscó asociación entre las variables demográficas y clínicas con la mortalidad y el tiempo de recuperación. Resultados: Treinta (0,60% pacientes con enfermedad de Graves fueron hospitalizados con el diagnóstico de agranulocitosis inducida por metimazol. La mediana de la edad fue 33,5 años y 86,67% fueron mujeres. Al ingreso, todos los pacientes presentaron fiebre y dolor de garganta. El manejo incluyó aislamiento invertido, suspensión del metimazol, administración de antibióticos y glucocorticoides. Doce (40% pacientes recibieron GM-CSF. El número de granulocitos se normalizó después de 10,59 días y cuatro (13,33% pacientes murieron por infecciones bacterianas y sepsis. En todos los casos, el tratamiento definitivo fue yodo radioactivo. No hubo diferencia significativa en la edad, sexo, dosis de metimazol, duración del tratamiento y uso de factor estimulante colonia, entre los pacientes fallecidos y los sobrevivientes. Además, el uso de factor estimulante de colonia no redujo el tiempo de recuperación de la agranulocitosis. Conclusión: La agranulocitosis inducida por metimazol es un evento adverso serio y potencialmente mortal. En este grupo de pacientes, la mortalidad fue elevada y el uso de factor estimulante de colonia no disminuyó el tiempo de recuperación.

  13. Polimorfismo genético relacionado con la probabilidad de desarrollar asma ocupacional en trabajadores expuestos a isocianatos

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    Gaetano Pepe Betancourt

    2014-03-01

    Full Text Available Introducción: El desarrollo tecnológico ha traído como consecuencia el uso de sustancias químicas potencialmente perjudiciales para la salud de los trabajadores. Particularmente el uso de isocianatos ha resultado en una mayor morbilidad de patología respiratoria, especialmente el asma. Considerando que no todos los trabajadores expuestos desarrollan la enfermedad se ha propuesto un modelo de interacción gen-medioambiental, el cual trata de explicar la predisposición genética que tienen algunos individuos a desarrollar asma ocupacional y otros no. Objetivo: Conocer la evidencia científica relacionada con el polimorfismo genético y la susceptibilidad que tienen los trabajadores expuestos a isocianatos a desarrollar asma ocupacional. Metodología: Se realizó una revisión sistemática mediante una búsqueda bibliográfica utilizando las bases de datos PubMedline, así como en los repositorios Dialnet y ELSEVIER. Se extrajeron los artículos relacionados al objetivo de esta revisión, no se aplicaron filtros de temporalidad, utilizándose los siguientes descriptores: MeSH Major Topic, MeSH Terms. El periodo de búsqueda fue desde el 20 de noviembre de 2013 y finalizó el 15 de diciembre de 2013. El nivel de evidencia se estableció de acuerdo a los criterios GRADE. Resultados: Se analizaron a texto completo 42 artículos, la evidencia científica se sustentó en 11 estudios de casos-controles. Dada la complejidad del polimorfismo genético asociado con la expresión fenotípica de la enfermedad, como limitación de los estudios, los autores coinciden que el tamaño muestral no es suficientemente grande, sin embargo después de ajustar los factores de confusión los artículos encontrados tuvieron un nivel de evidencia B de GRADE. Conclusión: La genética tiene una influencia significativa en el asma ocupacional inducida por isocianatos. El peso de la susceptibilidad genética y de la interacción gen-medioambiente aún no se han

  14. Fenotipo grave en dos medio hermanas con síndrome de Adams Oliver

    OpenAIRE

    Sevilla-Montoya, Rosalba; Ríos-Flores, Braulio; Moreno-Verduzco, Elsa; Domínguez-Castro, Mauricio; Rivera-Pedroza, Carlos I; Aguinaga-Ríos, Dra. Mónica

    2014-01-01

    El síndrome de Adams Oliver (AOS) es una entidad heterogénea con defecto transverso terminal de extremidades (TTLD) y aplasia cutis congénita (ACC) con un amplio espectro fenotípico. Se han descrito diferentes modos de herencia en esta enfermedad; los defectos más graves se han asociado a un patrón autosómico recesivo (AR). Objetivo. presentar a una familia con dos medio hermanas con un fenotipo grave de Adams Oliver, con una madre sana. Reporte del caso: una mujer de 27 años de edad fue refe...

  15. Efectividad de la fitoterapia en pacientes con asma bronquial The effectiveness of herbal medicine in patients suffering from bronchial asthma

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    Margarita García Quiala

    2012-02-01

    Full Text Available La medicina tradicional y la medicina complementaria y alternativa están adquiriendo más atención dentro del contexto de la provisión de atención sanitaria y la reforma del sector salud. Se han alcanzado importantes logros en cuanto a la efectividad de este procedimiento en los pacientes portadores de asma bronquial. Se realizó un estudio observacional descriptivo longitudinal con el objetivo de determinar la efectividad de la fitoterapia como uno de los tratamientos de la medicina natural y tradicional en 48 pacientes que padecen asma bronquial, pertenecientes al consultorio médico popular "La Amapola", Petare, del municipio Sucre en el año 2009. Se tuvieron en cuenta la edad, sexo, síntomas y signos presentes al momento del tratamiento, el período o estadio de la enfermedad, efectividad del tratamiento, la evolución y control de la enfermedad después de iniciado el tratamiento, obteniéndose como principales resultados que la mayoría pertenecían al sexo femenino y al grupo de edades de 10-14 años, seguidos de 5-9 años, los síntomas presentes en los pacientes fueron falta de aire y tos, el tratamiento utilizado en los pacientes atendidos por crisis de asma resultó efectivo en todas las variantes usadas, con predominio de la combinación de ajo más orégano más manzanilla; en solo 6-10 días habían mejorado los síntomas y en el transcurso de 3 meses la mayoría no habían presentado otra crisis de asma.An observational, descriptive and longitudinal study aimed at determining the effectiveness of herbal medicine as one of the treatments in Natural and Traditional Medicine for patients that suffered from Bronchial Asthma was conducted at "Amapola" Doctor's Office in Petare, Sucre District during 2009. Venezuela. The sample was chosen by means of a non-probabilistic per convenience sampling; selecting 48 asthmatic patients with inclusion criteria. The variables related to the objectives of the study were: age, sex, symptoms

  16. Asma Ahmed

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. Asma Ahmed. Articles written in Resonance – Journal of Science Education. Volume 14 Issue 5 May 2009 pp 455-471 General Article. The Major Players in Adaptive Immunity - Humoral Immunity · Asma Ahmed Banishree Saha Anand Patwardhan Shwetha ...

  17. Características de crianças hospitalizadas com asma grave no sul do Brasil = Characteristics of children hospitalized with severe asthma in southern Brazil

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    Veras, Tiago Neves

    2010-01-01

    Conclusões: a principal faixa etária dos pacientes internados por exacerbação de asma foi abaixo de três anos, com predomínio do sexo masculino e frequência aumentada no inverno. Constatou-se baixo índice de acompanhamento ambulatorial e uso de medicação preventiva. O seguimento preventivo, educação em asma e uso de profilaxia com corticóides inalados deve ser incentivado para diminuir as taxas de hospitalização por asma no Brasil

  18. Ventilação mecânica não invasiva na crise de asma aguda grave em crianças: níveis de evidências

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    Paula de Souza Silva

    2015-12-01

    Full Text Available RESUMO Objetivo: Avaliar a qualidade das evidências existentes para embasar diretrizes do emprego da ventilação mecânica não invasiva no manejo da crise de asma aguda grave em crianças não responsivas ao tratamento padrão. Métodos: Busca, seleção e análise de todos os artigos originais sobre asma e ventilação mecânica não invasiva em crianças, publicados até 1º de setembro de 2014, em todos os idiomas, nas bases de dados eletrônicas PubMed, Web of Science, Cochrane Library, Scopus e SciELO, encontrados por meio de busca pelos descritores "asthma", "status asthmaticus", "noninvasive ventilation", "bronchospasm", "continuous positive airway pressure", "child", "infant", "pediatrics", "hypercapnia", "respiratory failure", e das palavras-chave "BIPAP", "CPAP", "bilevel", "acute asthma" e "near fatal asthma". Os artigos foram qualificados segundo os graus de evidências do Sistema GRADE. Resultados: Foram obtidos apenas nove artigos originais. Destes, dois (22% apresentaram nível de evidência A, um (11% apresentou nível de evidência B e seis (67% apresentaram nível de evidência C. Conclusão: Sugere-se que o emprego da ventilação mecânica não invasiva na crise de asma aguda grave em crianças não responsivas ao tratamento padrão é aplicável à maioria desses pacientes, mas as evidências não podem ser consideradas conclusivas, uma vez que pesquisa adicional de alta qualidade provavelmente tenha um impacto modificador na estimativa de efeito.

  19. Asma bronquial y auriculoterapia

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    José Ramón Martínez Pérez

    2014-08-01

    Full Text Available El incremento de la morbimortalidad por asma y el manejo del paciente asmático representan problemas difíciles en la medicina moderna, esto fue el motivo para realizar un trabajo de revisión, con el objetivo de abordar aspectos relacionados con la aplicación de la auriculoterapia en el tratamiento de esta enfermedad, así como esclarecer los posibles efectos beneficiosos de esta modalidad terapéutica en la misma. Se concluye que el efecto corrector de la auriculoterapia sobre el asma se explica a través de mecanismos neurológicos, humorales, bioeléctricos e inmunológicos que producen broncodilatación, inmunomodulación y respuesta antiinflamatoria. Entre los puntos de la auriculopuntura más utilizados en el tratamiento del asma se incluyen a: shen men, simpático, asma y Ding chuan auricular. Se hacen algunas consideraciones sobre el tema

  20. Asma; tratamiento actual

    OpenAIRE

    Córdoba Mejía, Hernán; Fundación Valle de Lili

    2000-01-01

    ¿Qué es el asma?/ ¿Quiénes pueden tener asma?/ ¿Qué tan frecuente es el asma?/ ¿Cómo hago para saber si tengo asma?/ ¿Hay diferentes tipos de asma?/ ¿Cómo saber cuál es el tipo de asma que se tiene?/ ¿Cómo se trata el asma actualmente?/ ¿Los medicamentos antiasmáticos pueden ser administrados en diferentes formas?

  1. Asma bronquial y furosemida

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    José Ramón Martínez Pérez

    2014-08-01

    Full Text Available La compleja fisiopatología del asma bronquial se refleja en el manejo del paciente asmático, constituyendo un problema de salud en la medicina moderna. Se realizó una revisión bibliográfica, con el objetivo de abordar aspectos relacionados con la aplicación de la furosemida en el tratamiento de esta enfermedad, en busca de esclarecer posibles efectos beneficiosos de esta modalidad terapéutica. Se utilizaron los recursos disponibles en la red Infomed, mediante la cual se accedieron a bases de datos especializadas. De la bibliografía consultada se concluye que el efecto corrector de este fármaco sobre el asma se explica a través de mecanismos que involucran el transporte iónico a través de membranas celulares, produciendo acción directa sobre la vía aérea, efecto antitusígeno, vasodilatación pulmonar, sobre los derivados de la cicloxigenasa y antinflamatorio. Aún no se dispone de datos significativos que permitan concluir con certeza acerca de la efectividad del tratamiento, ya que existen discrepancias entre varios de los estudios realizados. Se recomienda prudencia y proceder con rigurosidad a la hora de experimentar el uso de la furosemida en el asma

  2. Tratamiento con inmunoterapia específica en niños con Rinitis Alérgica y/o Asma Bronquial. Área Norte. 2005 - 2007.

    OpenAIRE

    Matilde Iraida Morera Franco; Rigoberto Antonio García Chang; María Mercedes Gómez Paz

    2007-01-01

    Se realizó un estudio descriptivo longitudinal durante el período Enero 2005_ Enero 2007 en el Policlínico Norte del municipio Sancti Spíritus. El universo estuvo constituido por el total de niños con edades de 2_15 años con enfermedades alérgicas, a los que se realizó pruebas de alergia e indicó tratamiento con inmunoterapia específica por vía subcutánea, la muestra estuvo formada por 75 pacientes con asma bronquial, rinitis alérgica y/o ambas enfermedades, con el objetivo de determinar ...

  3. El asma bronquial y su asociación con los cambios de tiempo The bronchial asthma and its association with the changes in the weather

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    Tatiana de la Vega Pazitková

    2010-12-01

    Full Text Available INTRODUCCIÓN: el clima y el estado del tiempo influyen sobre la salud humana. El asma es una enfermedad psicosomática que constituye un problema de salud mundial, y es conocida la influencia de los factores ambientales en la aparición de las crisis de asma bronquial. OBJETIVOS: determinar los picos máximos de ocurrencia de las crisis de asma bronquial, en el municipio Playa, relacionándolas con los cambios meteorotrópicos. MÉTODOS: se recogió el total de personas que acudieron, diariamente, a los servicios de urgencia de los 9 policlínicos del municipio Playa, por crisis de asma bronquial, según hojas de cargo y reportes de la unidad de análisis y tendencias de salud municipal, entre el 1ro. de enero de 2007 y el 31 de diciembre de 2008. El dato recogido, acerca de la concurrencia de dichos pacientes, se contrastó con la información aportada por los mapas de modelos biometeorológicos. Se confeccionaron gráficos de frecuencia de casos, por día y por mes. Se realizaron intervalos para el histograma, y se ubicaron las diferentes policlínicas de acuerdo con los intervalos de frecuencia con que los pacientes acudieron a recibir los servicios de salud. RESULTADOS: bajo condiciones de hiperoxia atmosférica, la ocurrencia diaria de la enfermedad, mostró un valor igual o superior a 150 % de la media mensual respectiva, por lo que se evidenció una respuesta meteoro-patológica masiva de la población estudiada. CONCLUSIONES: los efectos meteorotrópicos asociados a los cambios bruscos del estado del tiempo pueden provocar impactos deletéreos sobre la salud humana.INTRODUCTION: the climate and the weather state influenced on the human health. The asthma is a psychosomatic disease which is a world health problem and it is known the influence of environmental factors on the appearance of bronchial asthma crises. OBJECTIVES: to determine the occurrence maximal peak of bronchial asthma crises in the Playa municipality relating it to the

  4. Síntomas de miastenia grave en un paciente con antecedente de timectomía por timoma invasor

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    Lilliana María Giraldo

    2015-12-01

    Conclusiones. Los pacientes con miastenia grave y aquellos con timoma asociado, deben someterse a la timectomía como parte del tratamiento. Sin embargo, la exacerbación de los síntomas o su reaparición después del procedimiento no necesariamente implica una nueva alteración en el timo.

  5. Nutritional support in patients with severe acute pancreatitis Soporte nutricional en pacientes con pancreatitis aguda grave

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    Mónica Marcela Peláez Hernández

    2007-04-01

    Full Text Available Severe acute pancreatitis is associated with a systemic inflammatory response leading to a hypermetabolic, hypercatabolic condition; for those reasons, patients suffering from this disease require an excellent artificial nutritional support in order to maintain the structural integrity and the function of vital organs with minimal pancreatic secretion. Total parenteral nutrition has been the standard practice in the treatment of patients with severe acute pancreatitis because of the favorable outcomes of early nutritional support while avoiding pancreatic stimulation; however, recent evidence suggests there are potentially greater benefits with enteral as compared with parenteral nutrition, including fewer septic and metabolic complications and lesser costs. That is why present guidelines for the management of acute pancreatitis recommend that enteral instead of parenteral nutrition be used in patients with severe acute pancreatitis. La pancreatitis aguda, especialmente en su forma grave, está asociada con una respuesta inflamatoria sistémica que lleva a un estado de hipermetabolismo e hipercatabolismo, en el que se requiere un excelente soporte nutricional que permita mantener la integridad estructural y la función de los órganos vitales con un estímulo mínimo de la secreción pancreática. La nutrición parenteral total era el soporte de elección, que permitía obtener todos los beneficios de la nutrición temprana sin estimular la secreción pancreática; pero la evidencia actual muestra mayores beneficios con la nutrición enteral, porque se asocia con menos complicaciones infecciosas y metabólicas y con disminución en los costos. Por ello las guías actuales de tratamiento de la pancreatitis aguda grave recomiendan como primera elección el soporte nutricional enteral.

  6. Inhibidor del factor de agregación plaquetaria como terapia coadyuvante en pacientes con asma esteroideo-dependiente, 2001

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    Luis Velásquez

    2001-04-01

    Full Text Available

    El asma es un desorden inflamatorio crónico de las vías aéreas que causa episodios recurrentes de sibilancias, disnea, opresión torácica y tos. Es una de las condiciones patológicas más frecuentes en la población general. Representa una entidad de alto costo no sólo por los días de incapacidad laboral y estudiantil que genera, sino también para el sistema actual de salud. A pesar de esto es una enfermedad poco entendida y cuyo tratamiento dista mucho de ser ideal.

     

  7. Metapneumovirus humano (hMPV asociado con exacerbación de asma aguda bronquial severa Human Metapneumovirus (hMPV associated to severe bronchial asthmatic crisis

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    M. A. López

    2006-09-01

    Full Text Available El metapneumovirus humano (hMPV es un nuevo agente causal de infección aguda del tracto respiratorio, recientemente reportado tras su hallazgo en niños, jóvenes, adultos y ancianos. Las manifestaciones clínicas producidas por el hMPV son indistinguibles de aquellas provocadas por los virus respiratorios clásicamente conocidos, y varían desde infección asintomática hasta neumonía complicada. Por otro lado, se han descrito casos de exacerbación de asma bronquial asociados a la infección con hMPV. En este trabajo se describe el caso de un niño hospitalizado que presentó una crisis asmática bronquial severa con sospecha de una infección viral asociada. Por el test de inmunofluorescencia indirecta no se detectaron virus sincicial respiratorio (VSR, adenovirus, virus influenza a - b ni virus parainfluenza 1, 2 y 3. En un intento por detectar la presencia de hMPV, se realizó una RT-PCR para la amplificación de los genes N y F con resultado positivo. Conforme a nuestro conocimiento, esta sería la primera descripción de un caso de exacerbación de asma asociado a hMPV en nuestra región. Los resultados de este estudio serían similares a los reportados por otros autores, quienes postulan que, a semejanza de lo que ocurre con el VSR, una infección por hMPV puede gatillar una enfermedad respiratoria crónica, como el asma.Human Metapneumovirus (hMPV is a recently reported agent of acute infection in the respiratory tract. It has been found in children as well as in young adults and elders. The clinical manifestations produced by hMPV are indistinguishable from those by common respiratory virus, and can evolve from asymptomatic infection into severe pneumonia. On the other hand, some authors have described cases of bronchial asthma exacerbation associated with hMPV infection. In this work we report a case of a child who presented a severe bronchial asthmatic crisis with a suspected viral associated infection. Immunofluorescence tests

  8. Asma en la adolescente embarazada

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    Vickie Shulman

    1998-08-01

    Full Text Available El embarazo entre las adolescentes ha aumentado en la última década1-5 asociado con frecuencia a la pobreza, al bajo nivel cultural y a una inadecuada atención prenatal. Aunque se ha sugerido que los resultados adversos del embarazo son más comunes entre las adolescentes procedentes de las zonas más pobres, datos recientes demuestran que dentro de la población blanca de clase media las madres adolescentes tienen más posibilidades de presentar resultados adversos.5 El asma también se está volviendo más común, con una incidencia de por lo menos un 6,6 % en muchachas de 15 a 16 años de edad.6,7 La pobreza y la vida en poblaciones marginadas están asociadas con el aumento de la mortalidad y la morbilidad del asma.8-11 Las adolescentes que padecen de asma y que quedan embarazadas representan un reto para el médico que debe considerar el impacto del asma sobre el embarazo y viceversa. El médico debe conocer los efectos tanto de los medicamentos que se usan para tratar el asma como de los efectos que puede tener sobre el feto la enfermedad inadecuadamente controlada. También el médico tiene que ser capaz de darle esta información a la adolescente de una manera apropiada que le permita tomar decisiones.12

  9. Tratamiento con inmunoterapia específica en niños con Rinitis Alérgica y/o Asma Bronquial. Área Norte. 2005 - 2007.

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    Matilde Iraida Morera Franco

    2007-10-01

    Full Text Available Se realizó un estudio descriptivo longitudinal durante el período Enero 2005_ Enero 2007 en el Policlínico Norte del municipio Sancti Spíritus. El universo estuvo constituido por el total de niños con edades de 2_15 años con enfermedades alérgicas, a los que se realizó pruebas de alergia e indicó tratamiento con inmunoterapia específica por vía subcutánea, la muestra estuvo formada por 75 pacientes con asma bronquial, rinitis alérgica y/o ambas enfermedades, con el objetivo de determinar el comportamiento del tratamiento con inmunoterapia específica se aplicó el método porcentual para el análisis de resultados, donde el grupo etáreo que predominó fue de 2 _5 años, más del 65 % de los pacientes tratados refirieron mejoría de los síntomas las causas más frecuentes de abandono de tratamiento fue la aparición de infecciones intercurrentes, no ocurrió reacción anafiláctica en ninguno de los casos estudiados, el tratamiento con inmunoterapia puede reducir el uso de otros tratamientos asociados como Intal, antihistamínicos, broncodilatadores y esteroides.

  10. Inalação contínua com fenoterol na criança com asma aguda grave: efeitos clínicos imediatos Continuous fenoterol inhalation by children with severe acute asthma: immediate clinical effects

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    Lourdes Z. Zanoni

    2002-09-01

    Full Text Available Objetivos: avaliar as alterações da freqüência cardíaca, da pressão arterial, do psiquismo e da saturação arterial de oxigênio, após a inalação contínua com fenoterol, na criança com asma aguda grave. Casuística e Métodos: foram estudados 30 pacientes com asma aguda grave, atendidos no PAM-Pediatria do Hospital Universitário - UFMS. Os pacientes receberam inalação contínua durante uma hora, com 0,5 mg/kg (2 gotas/kg de fenoterol. O psiquismo, a saturação arterial de oxigênio, a freqüência cardíaca e a pressão arterial foram avaliados antes, imediatamente após, e uma hora após a inalação com fenoterol. Resultados: 17 crianças eram do sexo masculino (56,6%, e 13 do sexo feminino (43,4%. Foi observado sonolência em 16 (53,3%, agitação psicomotora em 1 (3,3%, náusea e vômito em 12 pacientes (40%. A média da saturação arterial de oxigênio aumentou de 90,9 2,8% para 92,7 2,5% (pObjective: to evaluate the alterations of heart rate, blood pressure, psychological aspects and oxygen saturation after continuous fenoterol inhalation (0.5 mg/Kg by children with severe acute asthma. Methods: we studied 30 patients with severe acute asthma who were treated at the pediatric ward of Hospital Universitário - UFMS. The patients inhaled 0.5 mg/Kg of fenoterol (two drops/Kg during one hour. Psychological aspects, oxygen arterial saturation, heart rate and blood pressure were evaluated at three different moments: before, after and one hour after the fenoterol inhalation. Results: there were 17 males (56.6% and 13 females (43.4%. Sleepiness was observed in 16 (53.3%, psychomotor agitation in one (33% and nausea and vomiting in 12 patients (40%. The average of oxygen arterial saturation increased from 90.9 ± 2.8% to 92.7 ± 2.5% (P<0.05 after inhalation. There was statistically significant increase in the average heart rate before and after inhalation (139.5 ± 13.5 beats/min, 166.5 ± 11.1 beats/min, respectively, P<0.05. A

  11. Prueba cutánea con extractos alergénicos de pólenes y relación con signos clínicos de rinitis alérgica y asma bronquial en Camagüey, Cuba

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    Olimpio Rodríguez

    2013-08-01

    Full Text Available Los pólenes inciden sobre las mucosas provocando sensibilización alérgica, sin embargo, en Cuba son insuficientes los estudios sobre estos alergenos. Con el objetivo de conocer el comportamiento de Ambrosía psilostachya, Amaranthus leucocarpus, Helianthus annuus, Rumex acetosella, Lolium perenne, Cupressus lindley y Cocos nucifera, se realizó un estudio observacional analítico en el Servicio de Alergia del policlínico Previsora, Camagüey. La muestra fue de 529 individuos con rinitis o asma, con pruebas cutáneas por punción (prick test positivas a los ácaros, hongos y pólenes; el 40% de la misma estaba sensibilizada a pólenes con prueba de provocación nasal a estos alergenos. Se compararon según gravedad de los síntomas y los valores del habón de 3, 4 y 5 mm. Los grupos etarios con valores más altos de sensibilización fueron los de 6 a 12 y 19 a 44 años. No hubo diferencias significativas de sensibilización a los pólenes según sexo. Ambrosía y Lolium presentaron los porcentajes más altos de respuesta cutánea, con habones de 3 mm en un 49,98% y 40,09%, respectivamente. Tampoco se detectaron diferencias significativas. El 89,6% de los pacientes sensibilizados reaccionaron clínicamente a la provocación nasal. En los asintomáticos predominaron los habones de 3 mm y en los graves los de 5 mm. Los pólenes constituyeron una causa importante de sensibilización alérgica. Existió relación entre las pruebas cutáneas y la prueba de provocación nasal. El diámetro del habón de la respuesta cutánea a prick test se relacionó con la severidad de los síntomas clínicos.

  12. Omalizumab en el tratamiento de la rinosinusitis crónica con poliposis nasal

    OpenAIRE

    Martínez-Alonso, José Camilo

    2015-01-01

    [ES]Introducción y objetivo: Omalizumab es un tratamiento biológico indicado sólo en asma moderado-grave. El asma bronquial puede asociarse a poliposis nasal. Revisamos los estudios publicados sobre la eficacia de Omalizumab en el tratamiento de la poliposis nasosinusal. Método: Revisión bibliográfica narrativa. Discusión y Conclusiones: Omalizumab puede ser una alternativa terapéutica eficaz en pacientes con rinosinusitis crónica con poliposis agresiva. [EN] Introduction and objective: Om...

  13. Asma y atelectasia

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    Gladys Fernández Couse

    1997-04-01

    Full Text Available Se realiza un estudio de 155 niños, procedentes del cuerpo de guardia del Hospital Docente "José Ramón Martínez" de Guanajay, con el diagnóstico de asma bronquial, ingresados en el Servicio de Respiratorio para identificar posibles complicaciones según el juicio clínico del médico. En el 12,9 % de los pacientes se detectó la atelectasia como complicación, las manifestaciones clínicas de ésta quedaron enmascaradas por las de la crisis de asma bronquial. El pulmón derecho resultó ser el más afectado y la forma lobulillar fue la variedad que predominó. Se identificó un sobre diagnóstico de neumopatías inflamatorias, que se confundió con la atelectasia, lo cual trajo como resultado el uso indiscriminado de agentes antimicrobianos.It is conducted a study of 155 children from the Emergency Room of the "José Ramón Martínez" Teaching Hospital in Guanajay. These patients had a diagnosis of bronchial asthma and were admitted in the Respiratory Service to identify possible complications according to the clinical judgement of the physician. Atelectasis was detected as a complication in 12.9 % of the patients, and its clinical manifestations were masked by those of the bronchial asthma crisis. The right lung was the most affected and the lobular form was the predominant variety. It was detected an overdiagnosis of inflammatory pneumopathies that was confused with atelectasis, resulting in the indiscriminated use antimicrobial agents.

  14. Vías de administración de los corticosteroides en pacientes con crisis moderada de asma Ways of administration of corticosteroids in moderate asthma crisis

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    Carlos Dotres Martínez

    2012-12-01

    Full Text Available Objetivos: identificar las diferencias entre la administración de corticosteroides sistémicos parenterales y orales en el tratamiento de la crisis moderada de asma bronquial y el costo de su aplicación. Métodos: estudio descriptivo, prospectivo y aplicado, realizado en 105 pacientes asmáticos que acudieron al hospital pediátrico "Juan Manuel Márquez", entre el 1 de septiembre de 2009 y el 31 de mayo de 2011. Se organizaron tres grupos: grupo A, se administró hidrocortisona vía intramuscular; grupo B, metilprednisolona intramuscular y grupo C, prednisona oral. La selección y ubicación de los pacientes en los grupos fue al azar. Resultados: la duración de la crisis según vía de administración del corticosteroide fue de 1 a 3 días en 26 (74,3 % pacientes del grupo A, 24 (68,6 % asmáticos en el grupo B y 32 (91,4 % enfermos en el grupo C. La evolución de la crisis, con respecto a los días de dificultad respiratoria y la duración de la tos nocturna, tuvieron un comportamiento similar en los tres grupos. El costo del corticosteroide sistémico en el grupo A fue 13 veces superior al del grupo C y en el grupo B, fue 35 veces más que el del grupo C. Conclusiones: los corticoesteroides orales e intramusculares tienen la misma respuesta con respecto a la mejoría de los síntomas en pacientes con crisis moderada de asma bronquial. El uso del fármaco por vía oral conlleva un ahorro sustancial para el país y evita los efectos indeseables de la vía intramuscular.Objective: to determine the differences between the parenteral and the oral administration of systemic corticosteroids in moderate asthma crisis and the cost. Method: prospective and descriptive study performed in 105 patients, who presented with a moderate asthma crisis at "Juan Manuel Marquez" pediatric hospital from September 1, 2009 through May 31st, 2011. The patients were randomly selected and assigned to one of the following groups: Group A was given hydrocortisone

  15. Tratamiento y seguimiento de adultos con asma bronquial en las clínicas de la capital de Namibia Treatment and follow-up of adults with bronchial asthma in the clinics from the capital of Namibia

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    Elizabeth Oller Legrá

    2011-03-01

    Full Text Available Se hizo un estudio descriptivo y transversal de 196 pacientes con asma bronquial, atendidos durante el 2007 en las clínicas de Katutura (Namibia, para determinar algunos aspectos biomédicos y sociales relacionados con esa afección en los integrantes de la casuística. En la serie predominaron el sexo femenino, los grupos etarios de 25 a 44 años, el esquema terapéutico basado en broncodilatadores y esteroides, así como la ausencia de una terapia higienoambiental y rehabilitadora. De igual manera, no hubo seguimiento clínico y tratamiento adecuados según el grado de asma bronquial existente y las acciones de promoción de salud resultaron escasas.A descriptive and cross-sectional study of 196 patients with bronchial asthma was carried out. They were assisted in the clinics of Katutura (Namibia, during 2007 in order to determine some social and biomedical aspects related to this disorder in the members of the case material. In the series prevailed the female sex, the age groups from 25 to 44 years old, the therapeutical outline based on bronchodilators and steroids, as well as the lack of a rehabilitation and hygiene-environmental therapy. Similarly, there was neither appropriate clinical follow-up nor treatment according to the degree of existing bronchial asthma and there were just a few health promotion actions.

  16. O Manejo Clínico da Asma em 1999: Uma Visão e a Realidade da Asma na Europa (Estudo AIRE

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    K.F. Rabe

    2001-03-01

    Full Text Available RESUMO: As recomen dações sobre o manejo clfnico da asma fomecem orientações para urn controlo 6ptimo da asma. Esta investigação, avaliaua pelos niveis actuais do contwlo J a asma pelus doentes, ern parte retlete ate que pontu as recomendações sao implementadas.Doentes actuais com asma foram identificados por telefone e111 73 HHO residencias em 7 pafses europeus (França. Alemanha, ltalia, llolanua, Espanha, Suícia c lnglat crra. A entrevista consistiu na ava li ação da uti lizac;iio de serviços Lie saúde, gravidade de sintomas, limitação das actividades e controlo da asma.Foram identificados 3 488 doentes actuais com asma, e 2 803 (80.4% completaram o inquetito, 46% dos J oemes refeliram sintomas diaries e 30% perturbac;oes relacionadas com a asma durante o sono, pelo menos uma vez por sernana.Nos ultimos 12 meses, 25% dos doentes referiram o recurso mio e perado a uma consulta urgente, 10% uma ou mais visitas á urgencia e 7% hospitalizção noctuma devida a asma.Nas (iltimas 4 semanas, mais doentes (63% uti lizaram medicação aliviadora que corticóides inalados (23%. A percepção do controlo da asma pelos doentes nao coinciuia cum a sua gravidade de sintomas; c aproximadamente 50% dos doentes com sintomas persistentes moderados ou graves consideravam a sua asma bem ou total mente controlada.O nível actual do controlo da asrna na Europa está Ionge de ati ngir os objectives do tratamento a Iongo prazo. A percepção do controlo da asma pelos doentes e diferente do seu controlo da asma actual.

  17. ASMA SEVERA EN ADULTOS: ENFOQUE DIAGNÓSTICO Y TRATAMIENTO

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    Paulina Barría P., DRA.

    2015-05-01

    Full Text Available El asma es una enfermedad frecuente de fisiopatología compleja. El asma severa constituye aproximadamente el 5% de la población de asmáticos, sin embargo representa un desafío clínico y una carga sanitaria importante. Estudios recientes demuestran la existencia de fenotipos en todo el espectro de gravedad. La eosinofilia en esputo y sangre ha demostrado utilidad como marcador de inflamación Th-2 y de respuesta clínica a esteroides, sin embargo aún no existe mucho conocimiento sobre el asma no-eosinofílica. Los tratamientos actuales en asma se enfocan a estrategias de terapia escalonada según severidad, pero en pacientes con asma severa se requiere también del manejo multidisciplinario de las comorbilidades y la determinación del fenotipo, para aplicar terapias más especificas. El desarrollo acelerado de nuevos tratamientos en asma severa como consecuencia del mejor conocimiento de los distintos fenotipos ha ampliado el arsenal terapéutico para un enfrentamiento personalizado y específico en los pacientes con asma severa.

  18. Hidropesía fetal en una gestante con enfermedad hipertensiva grave. Presentación de un caso

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    Maribel Rodríguez Matos

    2013-09-01

    Full Text Available La hidropesía fetal es un grave proceso de elevada mortalidad perinatal, de etiología multifactorial, caracterizado por un síndrome edematoso generalizado, con o sin acumulación de líquido en las cavidades serosas del organismo fetal. Se presenta un caso de hidropesía fetal no inmunológica en una paciente de sexo femenino, de color de piel blanca y de 20 años de edad con enfermedad hipertensiva grave, diagnosticada mediante ultrasonido, como estudio de bienestar fetal a las 35,1 semanas de gestación, cuando fue remitida desde su área de salud por presentar cifras de tensión arterial de 160/100 mmHg. A su llegada al cuerpo de guardia de ginecobstetricia del hospital Héroes del Baire de la Isla de la Juventud se constataron cifras de 140/90 mmHg, se presentaba asintomática, por lo que se ingresó para estudio y tratamiento. Teniendo en cuenta el examen físico y el resultado del ultrasonido obstétrico, se decidió la interrupción de embarazo por cesárea de urgencia. Se recibió un recién nacido pretérmino de aspecto malformado. Se decide la presentación del caso por lo poco común de esta patología asociada a una enfermedad hipertensiva grave lo que incrementa el riesgo perinatal.

  19. Elaboración de una guía de práctica clínica de homeopatía para manejo de asma en niños con: Utilización de herramienta adapte 2.0 / Development of clinical practice guidelines for asthma manegement in children using agree 2.0 instrument

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    Ferreira R., Sandra Liliana

    2011-01-01

    El asma es la enfermedad respiratoria crónica más frecuente en pediatría a nivel mundial, la homeopatía es una alternativa muy valiosa para el tratamiento del asma. Dentro de los estándares de calidad establecidos por la ley Colombiana, se establece la obligatoriedad de la creación de guías de práctica clínica para todas las especialidades incluyendo la Homeopatía. En este contexto surge la necesidad de contar con guías de práctica clínica para el diagnóstico y manejo del asma en niños en ...

  20. Derrame pericárdico grave. Ventana pericárdica percutánea con balón

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    Carlos A. Bruno

    2008-01-01

    Full Text Available La mayoría de los pacientes con derrame pericárdico crónico son mujeres y mayores de 50 años. En esta presentación se describe el caso de una paciente de 63 años con derrame pericárdico crónico grave, con antecedente de carcinoma de mama izquierda irradiado, diagnóstico presuntivo no confirmado de tuberculosis pulmonar e hipotiroidea sustituida. Ante la recurrencia del derrame luego de pericardiocentesis y el fracaso del tratamiento antiinflamatorio con AINE se decidió realizar una ventana pericárdica percutánea, sin que se presentaran complicaciones técnicas. Se inició tratamiento con colchicina y se evaluaron las posibles causas: tuberculosa, oncológica, secundaria a hipotiroidismo o por radiación. Por exclusión se llegó a la etiología radiante. Al mes de la realización de la ventana pericárdica no se observaba derrame pericárdico en el ecocardiograma.

  1. A Aspirina e a Asma

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    K.S. Babu

    2001-03-01

    Full Text Available RESUMO: A aspirina é não só o fannaco me1hor estudado em todo o mundo, como o mais frequentemente uti1izado em todos os tempos. Alem das suas propriedades como analgesico e antipiretico, o acido acetilsalicflico (AAS e urn inibidor da agregação plaquetária, o que the confere urn papel essencial na profilaxia do tromboembolismo e na prevenção dos acidentes cardio e cerebro-vasculares.A associação da sensibilidade á aspirina, com a asma e a polipose nasal, descrita pela primeira vez por Femand Widal e colaboradores, constitui a trfade da “Asma lnduzida pela Aspirina” (AlA e refere-se ao desenvolvimento de urn quadro de broncoconstrição em indivfduos asmaticos após ingestao de aspirina. Nestes doentes, os sintomas agudos sobrepõem-se ao quadro clfnico de asma crónica grave. As crises de asma podem ser desencadeadas por pequenas quantidades de AAS ou de outros anti-inflamatórios nao ester6ides (AINE’ s.A prevalência da AIA na comunidade é incerta, mas os doentes com AIA constituem 10 a 20% da popula9ao asmatica, sendo a AIA mais frequente nas mulheres. Os autores deste trabalho fazem uma revisão teórica da AIA, descrevendo a apresentação clfnica, os mecanismos patogenicos, o diagnóstico e o tratamento deste síndrome.A asma e uma doença inflamatória crónica das vias aéreas. Neste estado de inflamação continua, a exposiyao aaspirina provoca no subgrupo de doentes com AIA uma acentuayao temporaria do processo inflamat6rio, que conduz á exacerbayao da asma. Embora assemelhando-se as reacçães de hipersensibilidade imediata, a AIA nao parece ser mediada por mecanismos dependentes da IgE, daí estas reacçães scrcm dcsignadas de “anafilactóides”.A hipersensibilidade à aspirina parece antes ser mediada por um desvio da via metab6lica do acido araquidónico no sentido da produção excessiva de leucotrienos, por

  2. Impacto do tabagismo parental sobre a asma infantil

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    Francisco-Javier Gonzalez-Barcala

    2013-06-01

    Full Text Available OBJETIVO: Avaliar a exposição da população infantil à FCA em nossa comunidade e sua relação com os sintomas de asma. MÉTODOS: Foi realizado um estudo transversal usando o questionário de estudo ISAAC em crianças e adolescentes da nossa comunidade. Pelo questionário, fez-se a definição por "já ocorreu sibilância", "asma atual", "asma grave" e "asma induzida pelo exercício". O tabagismo parental foi classificado em quatro categorias mutuamente excludentes: 1 nenhum dos pais fuma; 2 somente a mãe fuma; 3 somente o pai fuma; e 4 ambos os pais fumam. Calculou-se a odds ratio da prevalência de sintomas de asma, de acordo com a exposição à FCA, usando regressão logística. RESULTADOS: Foram incluídas, no total, 10.314 crianças e 10.453 adolescentes. Mais de 51% das crianças e adolescentes foram expostos à FCA em casa. A FCA se associa a uma prevalência mais alta de sintomas de asma, particularmente se a mãe ou ambos os pais fumam. CONCLUSÕES: A prevalência da FCA continua a ser alta em nossa comunidade, embora com uma tendência para diminuição nos últimos 15 anos. A FCA se associa a uma prevalência mais alta de asma.

  3. Valoración de la intervención en alumnado de secundaria con alteraciones graves de conducta (AGC

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    Manuel Espada Largo

    2017-01-01

    Full Text Available Los problemas de comportamiento en centros educativos son objeto de numerosas investigaciones (Mayorga y Oliver, 2006; Olweus, 1973a; Sela-Shayovitz, 2009; Sellman, 2011; Torrego y Galán, 2008. El objetivo de este estudio es describir cómo se interviene con alumnado con Alteraciones Graves de Conducta (AGC en los institutos públicos de la provincia de Toledo (España. El plan de investigación corresponde a un estudio de caso único de tipo intrínseco. Las técnicas de recogida y análisis de datos son cuantitativas vs. cualitativas complementariamente. Se diseñaron categorías de análisis prefiguradas a partir del marco teórico del estudio y se recogieron categorías emergentes. El instrumento utilizado fue un cuestionario de entrevista semiestructurada diseñado ad hoc. Los resultados indicaron que la intervención que se está desarrollando en los institutos públicos de la provincia de Toledo con este tipo de alumnado debería ser revisada. Existen diferencias importantes entre los criterios básicos de prevención, la atención desde un planteamiento integral de mejora de la convivencia y el nivel de aplicación real en los centros. Se aportan propuestas de mejora.

  4. Inmunoterapia con alérgenos: mecanismos de acción, impacto terapéutico y socioeconómico. Consenso de la Asociación Colombiana de Alergias, Asma e Inmunología

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    Jorge Sánchez

    2016-09-01

    Full Text Available Las alergias constituyen un conjunto de enfermedades de gran prevalencia. Cuando los procesos alérgicos no se controlan, pueden poner en peligro la salud e, incluso, la vida de los pacientes y, además, su efecto económico y social es considerable. El objetivo de esta revisión es presentar un consenso práctico de la información científica disponible sobre el empleo de la inmunoterapia en las enfermedades alérgicas con la colaboración de varios institutos y universidades de Colombia, por solicitud de la Asociación Colombiana de Alergia, Asma e Inmunología. La revisión incluyó aspectos prácticos presentados desde el punto de vista de médicos generales, alergólogos, inmunólogos, internistas y pediatras con experiencia en el campo de las alergias. Con base en la evidencia científica actual a nivel nacional e internacional, se describió de forma detallada en qué consiste la inmunoterapia, sus indicaciones, contraindicaciones y sus beneficios para la salud, así como en el ámbito socioeconómico. Se concluyó que la inmunoterapia es efectiva y segura, y que, además, puede reducir sustancialmente el costo del tratamiento global de los pacientes alérgicos.

  5. Percepción del profesorado de Educación Primaria hacia la inclusión del alumnado con ceguera y discapacidad visual grave en Asturias

    OpenAIRE

    Casado Camiña, Diego

    2014-01-01

    Trabajo de investigación que pretende conocer la percepción que tiene el profesorado de Educación Primaria sobre la inclusión educativa en las aulas ordinarias del alumnado con discapacidad visual grave o ceguera en Asturias.

  6. Osteoporosis grave con aplastamientos vertebrales en dermatomiositis juvenil: Efecto del tratamiento con alendronato oral Severe osteoporosis with vertebral crushes in juvenile dermatomyositis: Effect of oral alendronate therapy

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    Cristina Tau

    2007-02-01

    Full Text Available Los glucocorticoides son usados comúnmente para el tratamiento de enfermedades inflamatorias, autoinmunes, enfermedades malignas, y en la prevención de rechazo de órganos trasplantados. Un efecto secundario frecuente del tratamiento prolongado es la pérdida de masa ósea que se produce por varios mecanismos y es causa de osteoporosis y fracturas vertebrales. El tratamiento con disfosfonatos ha sido propuesto para esta situación. Presentamos un caso clínico de osteoporosis grave en una niña con dermatomiositis juvenil, que respondió favorablemente al tratamiento con disfosfonatos orales.Glucocorticoids are used for the treatment of inflammatory and autoimmune diseases, cancer, and in prevention of organ rejects. A frequent secondary effect of longterm treatment with corticoids is the loss of bone mass, caused by several mechanisms: decrease in the intestinal calcium absorption, increase of the renal calcium excretion at the distal renal tubule, suppressive effect on the osteoblast and also in apoptosis of osteoclasts, inhibition in local production of IGF I (Insulin-like growth factor and IGFBPs (binding IGF I proteins necessary for bone metabolism, and decrease on osteocalcin production. Longterm treatment with corticoids is associated with osteoporosis and vertebral fractures. To improve this condition, treatment with bisphosphonates has been proposed. We present here a clinical case of a girl with dermatomyositis and severe osteoporosis with vertebral crushes, who responded well to oral bisphophonate treatment.

  7. Forma rara de apresentação de corpo estranho traqueobrônquico simulando asma grave: Caso clínico Tracheobronchial foreign body aspiration simulating asthma attack: A case report

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    Miguel Guimarães

    2007-03-01

    Full Text Available O broncoespasmo é um dos sintomas clássicos de asma que pode ocorrer também em outras patologias. A aspiração de corpos estranhos traqueobrônquicos no adulto é uma dessas situações, que embora rara pode permanecer oculta por períodos de tempo prolongados. Os autores apresentam o caso clínico de um jovem asmático vítima de acidente de trabalho do qual resultou aspiração de corpo estranho pouco usual e só posteriormente reconhecido.Wheezing is a major symptom of asthma although it may be present in other pathologies. Foreign body aspiration a situation that often remains hidden for long periods of time. The authors present a case report of an asthmatic victim of workplace accident with aspiration of foreign body that was only suspected after some time.

  8. Valoración de la atención de urgencias al paciente con trauma grave

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    Gabriel Rodríguez Suárez

    2002-12-01

    Full Text Available Con el objetivo de determinar la calidad de la atención de urgencias a los pacientes que ingresaron en el Hospital Universitario "Doctor Gustavo Aldereguía Lima" de Cienfuegos, con el diagnóstico de trauma grave, se realizó un estudio descriptivo correlacionar. Se incluyeron 95 pacientes admitidos en unidades de cuidados progresivos durante el período de estudio, siguiendo el protocolo general de atención al trauma vigente en el Servicio. La edad media total de los lesionados fue de 39 años, con predominio del sexo masculino. El traumatismo craneoencefálico fue el más frecuente y de mayor mortalidad. Un análisis multivariado demostró que cerca del 50 % de los fallecimientos estuvo relacionado con la severidad de las lesiones, el tipo de trasporte utilizado y la demora en recibir los cuidados definitivosIn order to determine the quality of the emergency care received by the patients that were admitted at Doctor Gustavo Aldereguía Lima Teaching Hospital of Cienfuegos with the diagnosis of severe trauma, a correlative descriptive study was conducted. 95 patients who were admitted in progressive care units during the studied period were included, following the general protocol of trauma care that is in force at the Service. Total average age of the injured was 39. A predominance of males was observed. The cranioencephalic trauma was the most common and that with the highest mortality. A multivariate analysis showed that at about 50 % of the deaths were connected with the severity of the injuries, the type of transportation used and the delay in receiving the definitive care

  9. Contaminación biológica intradomiciliaria y su relación con síntomas respiratorios indicativos de asma bronquial en preescolares de Bucaramanga, Colombia

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    Astrid Berena Herrera

    2011-03-01

    Conclusiones. La exposición a contaminantes biológicos intramurales (ácaros y hongos, los antecedentes personales de prematuridad, neumonía o rinitis y el antecedente familiar de asma, incrementan la probabilidad de presentación de síntomas indicativos de asma bronquial en la población estudiada.

  10. Fluidoterapia de reanimación en pacientes con trauma grave: ¿Necesita cambiarse?

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    Mario Miguel Morales Wong

    Full Text Available El acceso venoso en los pacientes politraumatizados ha sido tradicionalmente una medida de suma importancia que permite la administración de líquidos, analgésicos, anestésicos y drogas reanimadoras. Convencionalmente en un paciente exanguinado, la administración vigorosa de cristaloides o coloides estuvo encaminada a restablecer de forma «empecinada» los valores de tensión arterial cercanos a la normalidad, en un intento por lograr la oxigenación tisular adecuada desde el preoperatorio. Sin embargo, se ha demostrado que tal estrategia de reanimación en este tipo de paciente aumenta la morbilidad y mortalidad de este debido a las graves anormalidades metabólicas que provoca, entre ellas la hipotermia, la acidosis, la coagulopatía y el resangrado de las lesiones vasculares previamente autocontroladas por los mecanismos fisiológicos de la coagulación. Hacemos una revisión de la literatura que refleja los relativamente nuevos puntos de vistas en la fluidoterapia de reanimación del paciente politraumatizado exanguinado

  11. Galactorrea grave tras aumento mamario con implantes Severe galactorrhea after mammary augmentation with implants

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    F.T. Fidalgo Rodríguez

    2012-06-01

    Full Text Available La galactorrea es una complicación poco frecuente después de la cirugía plástica mamaria. Su causa aun es desconocida, aunque lo más probable es que su aparición tenga un origen multifactorial. En el caso que presentamos la paciente desarrolló incremento simétrico del volumen de ambas mamas después de un cirugía de aumento mamario. No se detectaron cambios en los valores de prolactina. El proceso no respondió al tratamiento con bromocriptina. La galactorrea postquirúrgica con frecuencia sigue un curso benigno y autolimitado, culminando con resolución espontánea. Dependiendo de la severidad de los síntomas, su tratamiento puede ser médico y/o quirúrgico, con drenaje o incluso retirada de los implantes mamarios.Galactorrhea is a complication rarely observed after mammary plastic surgery. The cause remains unknown although it's likely to be multifactorial. In the reported case, the patient described symmetric massive engorgement of both breasts after augmentation mammoplasty. No significant change was detected in the postoperative prolactin values. The condition was unresponsive to treatment with bromocriptine. Postsurgical galactorrhea often follows a benign course culminating in spontaneous resolution Depending on symptom severity, treatment may be medical with the prescription of dopaminergic agonists, and/or surgical with drainage or even removal of the mammary implants.

  12. Características clínicas, perfil hormonal y marcadores de autoinmunidad de pacientes con enfermedad de Graves.

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    Deysy Cieza Diaz

    2008-10-01

    Full Text Available Objetivo: Describir las características clínicas, el perfil hormonal y los marcadores de autoinmunidad de pacientes con enfermedad de Graves (EG, atendidos en el servicio de endocrinología de un hospital general. Material y métodos: Estudio descriptivo, retrospectivo de pacientes con diagnóstico de EG atendidos en el servicio de endocrinología del Hospital Nacional Cayetano Heredia durante el año 2005. Los pacientes fueron identificados utilizando el Registro Diario de Atención y Otras Actividades del consultorio externo. Para el análisis estadístico se utilizó el programa SPSS versión 12,0. Resultados: Se revisaron 111 historias clínicas. La edad promedio fue de 40,6 ± 14 años. El 71,2% eran mujeres. El 20,7% tenía antecedente familiar de otra enfermedad autoinmune. El tiempo de enfermedad promedio antes de la consulta fue 18,9 ± 30,4 meses. Los síntomas más frecuentes fueron: tremor, piel delgada, palpitaciones y baja de peso. El peso promedio de la glándula tiroides estimado por palpación fue 69 ± 27,5 gr, 38,7% presentaba exoftalmos y 18,9% mixedema pretibial. El perfil hormonal mostró TSH suprimida, T4 libre y T3 total elevados. El 86,7% de los casos tenía autoanticuerpos anti-peroxidasa tiroidea (anti-TPO positivo. En 95,5% el tratamiento incluyó el uso de tionamidas. El análisis bivariado mostró que las mujeres tuvieron antecedente familiar de enfermedad tiroidea autoinmune en mayor frecuencia que los varones (27,8 vs. 9,4% (p=0,04. Conclusión: La población estudiada con EG fueron con mayor frecuencia mujeres entre la tercera y sexta década de la vida. El peso estimado de la glándula tiroides fue tres veces lo normal, con alta frecuencia de oftalmopatía y mixedema. La mayoría tiene marcadores humorales de autoinmunidad y el tratamiento inicial se basa en el uso de tionamidas. (Rev Med Hered 2008; 19:152-157.

  13. Enfermedad de Carrión grave complicada con leptospirosis aguda: reporte de un caso

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    Anderson Huerta

    Full Text Available Se reporta el caso de un adulto varón de 56 años, procedente de Sihuas (Ancash que acude al Hospital Nacional Dos de Mayo con cuadro clínico caracterizado por un síndrome ictérico febril anemizante, en cuya evolución tórpida de solo tres días de hospitalizado presenta anemia severa (Hb: 11,8 a 6,7 g/dL así como mialgias generalizadas asociadas a un empeoramiento brusco de la ictericia correlacionada con elevación de bilirrubinas (BT: 3,2 a 19,6 mg/dL a predominio directo y deterioro general del paciente; por ello, se realizó la investigación microbiológica donde se encontró frotis y cultivo positivo para Bartonella bacilliformis, posteriormente, la serología (microaglutinación resultó positiva para Lesptospira serovar Pomona. El paciente recibe tratamiento antibiótico específico (ceftriaxona y ciprofloxacino, se le transfunde dos paquetes globulares, mejora clínicamente y es dado de alta

  14. O formoterol e uma dose média/ elevada de corticosteróides inalados são mais eficazes do que uma dose elevada de corticosteróides na asma moderada e grave

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    G. Mitchell

    2003-05-01

    Full Text Available RESUMO: As normas internacionais para o tratamento da asma brônquica recomendam que os doentes com sintomatologia mal controlada com doses baixas/ /intermédias de corticosteróides (CT inalados sejam submetidos a doses mais elevadas de CT e, se necessário, deverá ser adicionado um β2 agonista de longa duração. No entanto, estudos mais recentes demonstraram que a adição deste fármaco a doses baixas/moderadas de CT inalados permite um melhor controlo da sintomatologia do que a duplicação da dose de CT. O formoterol constitui o β2 agonista de eleição devido ao seu início de acção rápida.O objectivo do presente trabalho foi comparar a eficácia da associação do β2 agonista formoterol a doses médias/elevadas de CT inalados com a duplicação da dose do CT em indivíduos com asma moderada/grave mal controlada.Foram avaliados doentes com idade superior a 18 anos com asma moderada e grave que apresentavam um FEV1≥50% do previsto e um aumento≥15% do referido parâmetro após inalação de um broncodilatador de curta duração, tendo sido submetido a terapêutica com CT inalados diariamente (dipropionato de beclometasona 1000 μ - budesonida 800 μg no mês que precedeu o início do estudo em análise. A existência de, pelo menos, dois dos parâmetros seguintes, nos últimos 7 dias do período de run-in, foi imprescindível: sintomatologia interferindo com as actividades de vida diária; interrupção do sono por sintomas nocturnos, necessidade de terapêutica de alívio numa dose≥4 puffs salbutamol/dia; variabilidade diária do PEF (Peak Expiratory Flow≥15%.Foram critérios de exclusão: doentes cuja dose do CT inalado diária foi alterada no último mês; indivíduos submetidos a CT oral ou β2 agonista de longa duração no mês precedente; doentes com dificuldade de utilizar o

  15. O formoterol e uma dose média/ elevada de corticosteróides inalados são mais eficazes do que uma dose elevada de corticosteróides na asma moderada e grave

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    G. Mitchell

    2004-09-01

    Full Text Available RESUMO: As normas internacionais para o tratamento da asma brônquica recomendam que os doentes com sintomatologia mal controlada com doses baixas/ /intermédias de corticosteróides (CT inalados sejam submetidos a doses mais elevadas de CT e, se necessário, deverá ser adicionado um β2 agonista de longa duração. No entanto, estudos mais recentes demonstraram que a adição deste fármaco a doses baixas/moderadas de CT inalados permite um melhor controlo da sintomatologia do que a duplicação da dose de CT. O formoterol constitui o β2 agonista de eleição devido ao seu início de acção rápida.O objectivo do presente trabalho foi comparar a eficácia da associação do β2 agonista formoterol a doses médias/elevadas de CT inalados com a duplicação da dose do CT em indivíduos com asma moderada/grave mal controlada.Foram avaliados doentes com idade superior a 18 anos com asma moderada e grave que apresentavam um FEV1≥50% do previsto e um aumento≥15% do referido parâmetro após inalação de um broncodilatador de curta duração, tendo sido submetido a terapêutica com CT inalados diariamente (dipropionato de beclometasona 1000 μ - budesonida 800 μg no mês que precedeu o início do estudo em análise. A existência de, pelo menos, dois dos parâmetros seguintes, nos últimos 7 dias do período de run-in, foi imprescindível: sintomatologia interferindo com as actividades de vida diária; interrupção do sono por sintomas nocturnos, necessidade de terapêutica de alívio numa dose≥4 puffs salbutamol/dia; variabilidade diária do PEF (Peak Expiratory Flow≥15%.Foram critérios de exclusão: doentes cuja dose do CT inalado diária foi alterada no último mês; indivíduos submetidos a CT oral ou β2 agonista de longa duração no mês precedente; doentes com dificuldade de utilizar o

  16. Hubungan Indeks Massa Tubuh Dengan Tingkat Kontrol Asma Pada Pasien Asma Di RSU Dr. Soedarso Pontianak

    OpenAIRE

    Fuad Akbar

    2015-01-01

    Latar Belakang: Asma merupakan masalah kesehatan di seluruh dunia yang penderitanya telah mencapai 300 juta orang. Pada saat ini, pencapaian dan pemeliharaan kontrol asma dalam jangka waktu yang lama merupakan tujuan dari terapi asma. Peningkatan indeks massa tubuh berperan dalam memperburuk tingkat kontrol asma Tujuan: penelitian ini dilakukan untuk mengetahui hubungan antara indeks massa tubuh dengan tingkat kontrol asma pada pasien asma di RSU dr. Soedarso Pontianak. Metode: Penelitian ini...

  17. Mujer joven con hipertiroidismo asociado a insuficiencia tricuspídea grave Young woman with hyperthyroidism associated with severe tricuspid regurgitation

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    Ariel K. Saad

    2008-02-01

    Full Text Available Las manifestaciones cardiovasculares del hipertiroidismo son frecuentes, y en ocasiones dominan el cuadro clínico. Con frecuencia, la enfermedad se manifiesta por un estado circulatorio hiperdinámico, con disminución de la resistencia vascular periférica, aumento de la volemia y del volumen minuto cardíaco. La dilatación de las cavidades cardíacas con insuficiencia tricuspídea grave e insuficiencia cardíaca derecha sin hipertensión pulmonar constituye una forma inusual de presentación. Se presenta el caso de una joven paciente, portadora de enfermedad de Graves Basedow, sin antecedentes cardiovasculares, que evoluciona en el transcurso de un mes con edema de miembros inferiores, palpitaciones, diarrea, pérdida de peso y fiebre. Al examen clínico se evidencian taquicardia con pulso irregular, signos de insuficiencia cardíaca derecha acompañado de un intenso soplo regurgitante que aumentaba con la inspiración. Por radiografía de tórax y ecocardiograma se constata cardiomegalia e insuficiencia tricuspídea grave sin hipertensión pulmonar. El cuadro se resuelve en forma rápida luego del tratamiento con propranolol, corticoides y diuréticos, con reversión de la arritmia y franca mejoría de los signos y síntomas. Se analizan en forma breve los efectos de las hormonas tiroideas en el aparato cardiovascular y se postulan probables mecanismos fisiopatológicos de la insuficiencia cardíaca en el hipertiroidismo.Cardiovascular manifestations of hyperthyroidism are frequent and sometimes are relevant in the clinical picture. Usually an hyperdynamic circulatory state hallmarks the disease with low peripheral resistance, increased intravascular volume and cardiac output. However, right chamber dilatation with tricuspid valve regurgitation and cardiac failure are unusual. We present the case of a young woman with Graves-Basedow disease without cardiovascular history who complained about palpitations, peripheral edemas, weight loss and

  18. Prevalencia de síntomas relacionados con el asma en escolares de Campos Gerais (MG, Brasil Prevalence of symptoms related to asthma among schoolchildren in Campos Gerais, Minas Gerais, Brazil

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    Paulo A. M. Camargos

    1999-07-01

    Full Text Available El asma es la enfermedad crónica más común en los niños y adolescentes y en los decenios más recientes se han registrado aumentos insólitos de su prevalencia en todas partes del mundo. Sin embargo, los estudios anteriores se han basado en distintos enfoques metodológicos, lo que dificulta hacer comparaciones entre los resultados. Ese factor estimuló a un grupo internacional de investigadores a elaborar un cuestionario estandarizado autoadministrable que permitiera llevar a cabo estudios internacionales en colaboración. Se creó así el instrumento utilizado en el International Study of Asthma and Allergies in Childhood (ISAAC o Estudio Internacional del Asma y las Alergias en la Niñez. Durante el mes de abril de 1996 se realizó en la ciudad de Campos Gerais, Minas Gerais, Brasil, un estudio transversal para determinar la prevalencia en escolares del estertor sibilante y otras señales y síntomas relacionados con el asma bronquial utilizando el cuestionario elaborado para el ISAAC. Se seleccionaron de forma aleatoria simple 200 adolescentes de 13 a 14 años de edad matriculados en escuelas públicas del municipio, los cuales fueron entrevistados más tarde por dos estudiantes de medicina. La muestra estaba distribuida igualmente (50% por sexo y edad. Se encontró que 28,5% de los escolares (IC95%: 22,3% a 35,3% habían experimentado por lo menos un episodio de sibilancia en algún momento del pasado y que 6% de ellos (IC95%: 3,1 a 10,5% habían tenido por lo menos una crisis asmática en los últimos 12 meses. Al comparar esos resultados con los obtenidos en ciudades brasileñas de mayor tamaño, se observa un aumento de las tasas de prevalencia que parece corresponder al aumento en densidad de la población y al grado de urbanización e industrialización de los municipios estudiados. Se refuerzan así las teorías que sostienen la existencia de una asociación entre el asma y los factores ambientales. De ello se desprende que es

  19. Caracterización de pacientes con paludismo grave por Plasmodium falciparum en una unidad de cuidados intensivos

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    Alberto García Gómez

    2017-12-01

    Full Text Available Introducción: el paludismo es la enfermedad parasitaria más importante del ser humano, causa anualmente entre uno y tres millones de muertes. Objetivos: caracterizar a los pacientes con paludismo grave por Plasmodium falciparum ingresados en una unidad de cuidados intensivos. Métodos: se realizó un estudio observacional, descriptivo en una Unidad de Cuidados Intensivos en Angola, de julio de 2014 hasta julio de 2016. La serie quedó constituida por 485 pacientes. Resultados: la serie representó el 99,6 % de los ingresos. La edad media fue de 23,4 ± 11,2 años. Predominaron el sexo masculino (66,4 % y los grupos de edades de 30 años o menos (83,6 %. La proporción del sexo masculino/femenino fue de 1,97:1. La mortalidad fue de 43,1 %. El sexo femenino tuvo mayor proporción de fallecidos (61 %. Fue más alto el por ciento de fallecidos en los que presentaron parasitemia >= 50000 x mm3. La media del valor del Acute Physiology, Age, Chronic Health Evaluation II fue de 14,8 ± 5,4; en los fallecidos fue superior que en los vivos (17,6 vs 12,3. Las complicaciones más frecuentes fueron de tipo neurológicas (90,1 %, hematológicas (77 %, respiratorias (61,8 %, hepáticas (58,7 %, y renales (40,3 %. El 51,6 % de los pacientes recibieron ventilación mecánica. Conclusiones: los jóvenes representaron la mayor parte de los ingresos por malaria en la unidad de cuidados intensivos, un porcentaje alto requirió ventilación mecánica, la mortalidad en las mujeres fue mayor y la global elevada.

  20. Mediadores inflamatorios en el asma

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    Roberto Alvarez Sintes

    1995-04-01

    Full Text Available Se describen los mediadores inflamatorios que intervienen en los cambios característicos del asma bronquial; mastocitos, macrófagos, eosinófilos, neutrófilos, células epiteliales y plaquetas.

  1. Caracterización de gestantes con asma bronquial en el barrio "José Félix Ribas" del municipio venezolano de Sucre Characterization of pregnant women with bronchial asthma in "José Félix Ribas" district of the Venezuelan municipality of Sucre

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    Bartolo Maldonado de los Reyes

    2012-08-01

    Full Text Available Se realizó un estudio descriptivo, transversal y prospectivo de 120 gestantes con asma bronquial en el barrio "José Félix Ribas" del municipio venezolano de Sucre, desde enero hasta diciembre de 2010, con vistas a caracterizarles desde el punto de vista clinicoepidemiológico. Para la recolección de la información se utilizó una planilla de datos y un cuestionario que fue procesado con la versión 6.0 del programa Epi Info. En la casuística primaron las adolescentes (56,6 %, de las cuales, 55,8 % tuvieron contacto de forma activa o pasiva con el humo del cigarrillo y 68,3 % presentaron asma bronquial grado I; asimismo, predominaron los factores desencadenantes (100,0 %, seguidos de los causales (95,8 %, de manera que las características clinicoepidemiológicas de estas embarazadas hacen que el asma bronquial sea un problema de salud para este grupo poblacional.A descriptive, cross-sectional and prospective study was carried out in 120 pregnant women with bronchial asthma in "José Félix Ribas" district of the Venezuelan municipality of Sucre, from January to December 2010, to characterize them clinically and epidemiologically. For gathering information a data sheet and a questionnaire that was processed with version 6.0 of Epi Info program were used. Adolescents (56.6 % prevailed in the case material, of them 55.8 % had active or passive contact with the cigarette smoke, and 68.3 % presented with grade I of bronchial asthma. Also, trigger factors prevailed (100.0 %, followed by causal factors (95.8 %, so that clinical and epidemiological characteristics of these pregnant women make a health problem of bronchial asthma in this population group.

  2. Mortalidade relacionada à asma no Município do Rio de Janeiro, Brasil, no período de 2000-2009: análise de causas múltiplas Mortalidad relacionada con el asma en el Municipio de Río de Janeiro, Brasil, durante el período de 2000-2009: análisis de causas múltiples Asthma-related mortality in the city of Rio de Janeiro, Brazil, 2000-2009: a multicausal analysis

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    Gulnar Azevedo e Silva

    2013-04-01

    Full Text Available O estudo das causas múltiplas de óbitos permite conhecer a extensão real das estatísticas de mortalidade. O objetivo desta pesquisa foi avaliar a tendência das taxas de mortalidade relacionada à asma, no Município do Rio de Janeiro, Brasil, no período de 2000-2009, com dados obtidos no Sistema de Informações de Mortalidade (SIM, de indivíduos com um ano ou mais de idade, em que a asma foi mencionada em qualquer linha ou parte do atestado médico da declaração de óbito. Para análise de dados foi utilizada a técnica de regressão linear. A série histórica mostrou tendência ao declínio nas taxas de mortalidade padronizadas relacionada à asma como causa básica e múltipla, com redução entre os homens e estabilidade entre as mulheres. Quando a asma foi a causa básica, as causas associadas mais frequentes foram doenças do aparelho respiratório. A mortalidade relacionada à asma foi subestimada quando considerada apenas como causa básica, o que poderia ser evitado com a utilização da metodologia de causas múltiplas nas estatísticas de mortalidade por asma.El estudio de las causas múltiples de óbitos permite conocer la extensión real de las estadísticas de mortalidad. El objetivo de esta investigación fue evaluar la tendencia de las tasas de mortalidad, relacionada con el asma, en el municipio de Río de Janeiro, Brasil, en el período de 2000-2009, con los datos obtenidos en el Sistema de Información de Mortalidad (SIM, de individuos con un año o más de edad, en quienes el asma fue mencionada en cualquier línea o parte del certificado médico de defunción. Para el análisis de datos fue utilizada la técnica de regresión lineal. La serie histórica mostró una tendencia al declive en las tasas de mortalidad estandarizadas, relacionada con el asma como causa básica y múltiple, con reducción entre los hombres y estabilidad entre las mujeres. Cuando el asma fue la causa básica, las razones asociadas m

  3. Caracterización clinicoepidemiológica de pacientes con asma bronquial en un consultorio rural de Chivirico Clinical and epidemiological characterization of patients with bronchial asthma in a rural doctor's office in Chivirico

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    Carlos Luis Milán Lemus

    2010-09-01

    Full Text Available Se hizo un estudio descriptivo y transversal de 45 pacientes asmáticos, mayores de 15 años, pertenecientes al consultorio médico de la familia "El Mazo" en Chivirico, municipio de Guamá, desde enero hasta diciembre de 2006, ambos meses inclusive, con vista a caracterizarles para conocer cómo se manifestaba el asma bronquial en esta zona rural y se obtuvo una mayor incidencia de la enfermedad en las personas de 15 a 24 años y del sexo masculino. La generalidad de los encuestados tenían un bajo nivel de escolaridad y el mayor porcentaje de ellos presentó un estadio ligero intermitente del cuadro clínico. También se observó que el hábito de fumar, el género de vida regular y la ausencia del tratamiento intercrisis fueron los factores de riesgo más frecuentes en la casuística.A descriptive and cross-sectional study was carried out in 45 asthmatic patients over age15, belonging to "El Mazo" family doctor's office in Chivirico, Guamá municipality, from January to December, 2006, including both months, with the purpose of characterizing them to know how evident bronchial asthma is in this rural area. A higher incidence of the disease was obtained in male patients between15 and 24 years. Most of the respondents had a low educational status and the highest percentage of them presented with an intermittent mild stage of the clinical pattern. It was also noted that smoking, a regular mode of life and the absence of intercrisis treatment were the most frequent risk factors in the case material.

  4. Biofeedback: Infant asthma Biofeedback: asma infantil

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    J. J. Nombela

    2010-09-01

    Full Text Available

    The present study is a revision of the different applications of biofeedback in infantile bronchial asthma. The technique may be used on its own (preferably in the motor area or in conjunction with other techniques such as hypnosis, relaxation, etc. However, it should be stated that previous work published in this field is difficult to interpret since results are inconclusive, it is, therefore, difficult to produce a scientific summary.

    KEY WORDS: Biofeedback; infantile asthma; respiratory biofeedback.

    Con este trabajo se pretende hacer una revisión sobre las distintas aplicaciones del biofeedback en el asma bronquial infantil, bien solo (preferentemente en el campo motriz o bien asociado a otras técnicas de hipnosis, relajación, etc. Aunque es necesario manifestar que la producción científica relacionada con el tema, hace que tenga una difícil valoración dado que sus resultados son no concluyentes y discutibles, lo cual dificulta la elaboración de un resumen científico.
    PALABRAS CLAVE: Biofeedback; asma infantil; biofeedback respiratorio

  5. Características de los exámenes de laboratorio en pacientes con dengue grave en un hospital de Puerto Maldonado - Perú

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    Jesús Rojas-Jaimes

    2014-07-01

    Full Text Available Introducción: Puerto Maldonado, capital del Departamento de Madre de Dios, es catalogado como zona endémica de dengue. La clasificación de dengue considera al dengue grave (hemorrágico cuando se produce shock, distrés respiratorio o compromiso de órgano blanco. Objetivos: Determinar las características de los exámenes de laboratorio en pacientes con dengue grave hospitalizados en la Unidad de Cuidados Intermedios del Hospital Santa Rosa de Puerto Maldonado, Madre de Dios, Perú. Diseño: Estudio retrospectivo de corte transversal. Institución: Laboratorio Central y Departamento de Epidemiología del Hospital Santa Rosa, Madre de Dios, Perú. Materiales: Cincuenta y cinco historias clínicas de pacientes con diagnóstico de dengue grave hospitalizados en la Unidad de Cuidados Intermedios, en el periodo junio de 2010 a noviembre de 2011. Métodos: Se analizó los resultados de exámenes de laboratorio solicitados durante la hospitalización. Principales medidas de resultados: Valores de transaminasas, creatinina, hemograma completo y examen de orina. Resultados: El mayor número de pacientes con dengue grave procedió de Puerto Maldonado (84%. El grupo etario mayormente afectado fue el de 40 a 49 años (32%. En 83% de los pacientes hospitalizados se presentó elevación de las transaminasas y de la creatinina sérica. El recuento de plaquetas estuvo dentro de rangos normales, excepto en el grupo de 10 a 19 años (11%, en quienes se halló concentraciones séricas de plaquetas menores a 150 000/mL. Conclusiones: En la mayoría de pacientes hospitalizados por dengue grave en Puerto Maldonado existió elevación sérica de transaminasas y creatinina. El recuento de plaquetas fue normal, pero existió plaquetopenia en el grupo de 10 a 19 años.

  6. Variabilidad genética de Plasmodium falciparum en pacientes con malaria grave y malaria no complicada en Iquitos - Perú

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    Gisely Hijar G

    2002-07-01

    Full Text Available Objetivo: Determinar la diversidad genética del gen que codifica la proteína rica en glutamato (GLURP de Plasmodium falciparum en pacientes con malaria complicada y no complicada circulante en un área del departamento de Loreto, distrito de Maynas. Materiales y métodos: La diversidad genética fue analizada usando reacción en cadena de la polimerasa (PCR en 30 muestras sanguíneas de pacientes con malaria no complicada (MNC y 46 con malaria grave complicada (MGC. Resultados: Ocho genotipos fueron detectados en pacientes con MNC (Genotipo I,II,III, IV,V, VI,VII y VIII y cuatro genotipos en los pacientes con MGC (Genotipo V,VI,VII,VIII. Asimismo, en 50% de las muestras con MNC fueron detectadas infecciones múltiples, a diferencia de las muestras de MGC en donde no se detectó infecciones múltiples. Conclusión: Existe una diversidad genética en esta región del gen GLURP de P. falciparum, para esa época (marzo 1998 - abril 1999 y esa área del país. En tal sentido, nuestros resultados podrían servir de base para llevar a cabo estudios epidemiológicos posteriores, ya que permitiría conocer la distribución de las cepas circulantes en nuestro país.

  7. Relación entre las infecciones respiratorias agudas altas y el asma bronquial

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    Verónica Soler Fonseca

    Full Text Available Introducción: la infección respiratoria es la enfermedad más frecuente en los seres humanos, pues es responsable de la mitad de todas las enfermedades agudas. En Cuba al igual que en el resto del mundo, el asma bronquial constituye un importante problema de salud con incidencia relevante en los niños. Se señala que las infecciones virales están involucradas en la patogénesis del asma, sobre todo en el paciente pediátrico. Objetivo: identificar la influencia de las Infecciones Respiratorias Agudas Altas en la aparición y exacerbación de las crisis de asma bronquial. Métodos: se realizó un estudio descriptivo, transversal y prospectivo de los pacientes ingresados con asma bronquial en el servicio de enfermedades respiratorias del Hospital Pediátrico Docente de San Miguel del Padrón, durante todo el año 2008. Resultados: el tiempo de evolución de la IRAA más frecuente que desencadenó la crisis de asma bronquial fue de más de 7 días, con un 54,8 %. Un total de 188 pacientes presentaron rinofaringitis aguda catarral relacionada con la aparición de la crisis de asma bronquial, lo que representó el 82,4 % del total de la muestra. Conclusiones: predominó el grupo de 1 a 4 años con manifestaciones respiratorias altas de posible etiología viral sin diferencias apreciables en relación con el sexo. La mayoría de los pacientes que participaron en el estudio presentaron IRAA de etiología viral (Rinofaringitis, que precedieron la aparición y exacerbación de las crisis agudas de asma bronquial.

  8. Prevalencia de síntomas respiratorios indicativos de asma y asociación con contaminación atmosférica en preescolares de Bucaramanga, Colombia

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    Laura Andrea Rodríguez

    2010-03-01

    Conclusiones. Es posible que en Bucaramanga los factores de contaminación domiciliaria puedan tener un mayor efecto sobre la presencia de síntomas respiratorios indicativos de asma en menores de siete años que los contaminantes externos.

  9. LATIHAN FISIK MENCETUSKAN ASMA

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    Afriwardi Afriwardi

    2008-05-01

    Full Text Available AbstrakAsma yang dicetuskan latihan fisik (exercise-induced asthma merupakan suatu kelainan yang ditandai dengan terjadinya bronkospasme serta hipersekresi mukosa bronkus yang dicetuskan oleh kegiatan olahraga atau aktifitas fisik. Kami melaporkan satu kasus seorang atlet putri karate, umur 24 tahun yang sudah menekuni olahraga selama 10 tahun. Serangan sesak nafas yang kadang menimbulkan mengi dan dada terasa berat seringkali timbul saat melakukan latihan. Pada umumnya sesak dan dada berat akan berkurang setelah latihan dihentikan. Diagnosis ditegakkan dengan anamnesis dan pemeriksaan fisik yang dilakukan pada saat serangan yang terakhir serta adanya catatan medis yang sempat terdokumentasi. Perlu dilakukan kajian yang mendalam terhadap kasus ini karena serangan tersebut sangat mengganggu program latihan yang diberikan untuk atlet tersebut. Penelusuran terhadap faktor pencetus serta pemahaman karakteristik serangan akan sangat membantu pelatih dalam menyiapkan program latihan untuk atlet ini guna memperoleh prestasi terbaik.Kata kunci: exercise induced asthma – diagnosis - program latihanAbstractAsthma triggered by physical exercise (exercise-induced asthma is a marked disorder with the occurrence of bronchospasm and hypersecretion of bronchial mucous triggered by sports or physical activity. We report a case of a karate sportswoman, aged 24 years old who has engaged in sports for 10 years. Shortness of breath attacks that sometimes followed with wheezing and chest heaviness often occurs during exercise. In general, shortness of breath and chest heaviness will decrease after the training is stopped. Diagnosis by interview and physical examination conducted at the time of the attack, and documented n the medical record. In-depth study of the case need to be performed because the attack seriously affects training provided to the athlete. Studying the triggering factors and understanding the characteristics of the attack will greatly help

  10. Asma y tabaquismo, ¿Una asociación bidireccional?

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    Jair Andrés Medina-Páez

    2014-12-01

    Full Text Available El asma es una enfermedad crónica caracterizada por hiperreactividad de la vía aérea que puede desencadenarse por diversos mecanismos, entre los cuáles el tabaquismo evidencia una estrecha asociación con el desarrollo y progresión de la enfermedad pulmonar. A pesar de lo anterior, la asociación del asma en la niñez con el desarrollo del tabaquismo en la adultez no ha sido ampliamente propuesta. En general, se ha reportado que así como el tabaquismo puede preceder el asma en adultez, en otros casos el asma precede esta relación. De tal manera, los asmáticos comienzan a fumar a menor edad y entre mayor es la sintomatología, mayor el riesgo de ser fumador regular. Lo anterior sustenta una probable relación bidireccional entre el tabaquismo y el asma, a pesar que no es clara la dirección del efecto de la condición asmática sobre el hábito tabáquico. De tal forma, el propósito de la presente revisión es describir dicha asociación bidireccional entre el asma y el tabaquismo.

  11. Asma de difícil control en niños y adolescentes: Estrategias diagnóstico-terapéuticas

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    Hugo Neffen

    2012-10-01

    Full Text Available El asma es una de las enfermedades crónicas más frecuentes en los niños. Si bien la mayoría de los niños con asma responden a bajas dosis de corticoides inhalados y/o antagonistas del receptor de leucotrienos, algunos de ellos permanecen sintomáticos independientemente de cualquier esfuerzo terapéutico, presentando una elevada morbilidad e inclusive mortalidad. Aunque la mayoría de los pacientes controlan los síntomas de forma adecuada, existe un grupo importante que presenta síntomas graves de la enfermedad difíciles de controlar (ADC. El objetivo de la presente revisión es discutir los aspectos clínicos, diagnósticos y terapéuticos del ACD en los menores de 18 años y su implicancia en la práctica clínica diaria.

  12. Del crecimiento personal hacia la cohesión grupal: la arteterapia como vía transicional en un centro de día con personas diagnosticadas con trastorno mental grave

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    Morán Reyes, Oyuky

    2017-01-01

    La prevalencia de los Trastornos Mentales Graves (TMG) continúa incrementándose y afectando a millones de personas. La comorbilidad con otras enfermedades y la descompensación física, emocional y social, se convierten en una gran barrera que coloca a este colectivo en “riesgo de exclusión”. El Plan de Acción sobre la Salud Mental 2013-2020, mediante una amplia red de servicios Socio-Sanitarios, impulsa Programas y Propuestas de Intervención que favorecen el proceso de Recuperación de las p...

  13. ENFOQUE EN LA ATENCIÓN INTEGRAL A LOS PACIENTES CON TRASTORNO MENTAL GRAVE TREINTA AÑOS DESPUÉS DE LA REFORMA PSIQUIÁTRICA

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    Agustín Madoz-Gúrpide

    2017-01-01

    Full Text Available Han pasado más de 30 años desde el inicio de los procesos de reforma psiquiátrica, periodo además de importantes e intensos cambios sociales, científicos y culturales que afectan de manera directa a la enfermedad mental grave y a su manejo. Las mejoras del tratamiento farmacológico, un nuevo modelo de relación médico-paciente, el empoderamiento del paciente como elemento clave y la lucha contra el estigma social de la enfermedad, los cambios en la gestión de los recursos, el incremento de la carga que suponen los pacientes con patología menor en los centros de salud mental, las mejoras en el trabajo en equipo y en la coordinación de los recursos implicados… son algunas de las modificaciones importantes que condicionan el escenario de la atención en salud mental comunitaria. Se nos antoja, por tanto, como un buen momento para revisar el estado de los programas de gestión del trastorno mental grave en el adulto y de los centros de salud mental, y plantear dos cuestiones sencillas a la par que relevantes: dónde estamos y hacia dónde nos dirigimos.

  14. Peningkatan Kekuatan Otot Pernapasan dan Fungsi Paru melalui Senam Asma pada Pasien Asma

    OpenAIRE

    Sahat, Camalia S; Irawaty, Dewi; Hastono, Sutanto Priyo

    2011-01-01

    Pasien asma mengalami bronchospasme dan bronchokontriksi yang dapat menyebabkan penurunan fungsi pernapasan. Penelitianbertujuan mengidentifikasi pengaruh senam asma terhadap peningkatan kekuatan otot pernapasan dan fungsi paru pasien asmadi perkumpulan senam asma. Desain penelitian yaitu kuasi eksperimen dengan desain kelompok kontrol. Sampel berjumlah 50pasien, diambil dengan purposive sampling, dan terdiri atas kelompok intervensi dan kontrol. Hasil penelitian menunjukkanhubungan antara se...

  15. Análisis funcional y tratamiento de un paciente con graves problemas de conducta diagnosticado de trastorno límite de la personalidad

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    Javier Virués Ortega

    2004-01-01

    Full Text Available Se presenta el caso de un paciente con diagnóstico de trastorno límite de personalidad institucionalizado en una comunidad terapéutica hospitalaria con una historia psiquiátrica prolongada y múltiples problemas de comportamiento asociados. Por motivos de eficiencia y ajuste del tratamiento al paciente se aplica un análisis funcional exhaustivo de las conductas-problema. Se usan tres fuentes de información: los registros de enfermería, rejilla de observación y entrevista conductual. Las dos primeras fuentes permitieron apoyar el análisis funcional con probabilidades condicionales. La intervención consideró el control de consumo de estimulantes, aumento de actividades de ocio, aumento de comportamientos de autocuidado y reducción de conductas- problema mediante economía de fichas y control de contingencias. Estas medidas fueron implementadas en un contrato conductual. Durante los dos meses de vigencia del tratamiento se observó una dramática reducción de todos los comportamientos problema, así como de otras conductas que no fueron objeto directo de intervención. Se discute el uso de esta metodología en trastornos de personalidad y otros trastornos graves como nuevas áreas de aplicación de la psicología conductual.

  16. Educación para el manejo y control del asma infantil. Proyecto: "Yo controlo mi asma"

    OpenAIRE

    Martínez Masot, Raquel

    2016-01-01

    El asma bronquial es una enfermedad respiratoria crónica común en la infancia. En España afecta sobre todo en la costa noroeste atlántica. Los niños asmáticos deben saber cómo manejar y controlar su enfermedad. Por lo tanto, la educación sanitaria dirigida a esta población infantil es esencial. Por eso, se ha elaborado una intervención educativa basada en actividades didácticas, de participación y cooperación con el fin de mejorar la independencia del niño frente a su asma así como su control...

  17. Conceptos Básicos en Asma Bronquial

    Directory of Open Access Journals (Sweden)

    Alfredo Jácome Roca

    2001-04-01

    Full Text Available

    Si hay una patología común en medicina, especialmente en pediatría, esta es el asma bronquial.

    Más de cien millones de asmáticos habitan en la tierra; y aunque nunca antes se había sabido tanto de la fisiopatología de esta enfermedad, ni ha habido tantos fármacos y medios de tratarla, en un sinnúmero de casos ni los padres ni los médicos parecen encontrarle salida a tan desesperante situación.

    Nadie más preparado en nuestro medio para analizar este tema que el Profesor Eduardo De Zubiría, insigne internista y reconocido alergista de la tradicional escuela de La Samaritana, que desarrollara en compañía de su hermano Roberto, y de quienes tuve la fortuna de ser alumno en 1960.

    Eduardo y sus dos hijos De Zubiría Salgado (Eduardo Jr. Y Alberto navegan con autoridad por ese mundo fantástico de los mastocitos, de los eosinófilos y de los linfocitos, de las inmunoglobulinas, de los mediadores, de las linfoquinas y de todo aquello que configura las reacciones alérgicas, el espasmo y la hiperreactividad bronquiales.

    No podría tampoco faltar en la obra el capítulo sobre ácaros, de los expertos Mario Sánchez Medina y Luis Caraballo, quienes desde hace muchos años vienen investigando sobre este tema en Colombia.

    El libro está elaborado con una secuencia muy didáctica, pues comienza con la epidemiología de la enfermedad y continúa, entre otros, con temas fisiopatológicos, discutiendo en detalle aquellas células y mediadores de la inflamación y de la respuesta alérgica, y en particular los anticuerpos, destacándose entre ellos la inmunoglobulina E.

    Los pacientes con hiperreactividad bronquial son más dados a sufrir los ataques espasmódicos que llevan a la obstrucción de las vías aéreas, yen algunos casos a las dramáticas y peligrosas crisis asmáticas, que tan frecuentemente vemos en los servicios de urgencias y que resultan tan onerosos para nuestro sistema de salud.

    El texto

  18. Comportamiento del fallo renal agudo en niños con sepsis grave Behavior of acute renal failure in children presenting with severe sepsis

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    María del Carmen Saura Hernández

    2010-03-01

    Full Text Available INTRODUCCIÓN. El objetivo de esta investigación fue determinar los factores de riesgo asociados al fallo renal agudo (FRA en un grupo de niños con sepsis grave atendidos entre enero del 2004 y diciembre del 2008. MÉTODOS. Se realizó un estudio observacional y analítico con una muestra de 171 pacientes. Se constituyeron dos grupos: el de estudio, integrado por 38 pacientes con estado de choque séptico o disfunción múltiple de órganos (DMO y FRA, y un grupo control, conformado por 133 niños en igual estadio de sepsis pero con función renal normal. Se revisaron las historias clínicas y se tuvieron en cuenta variables epidemiológicas, factores de riesgo de FRA y evolución de los casos. RESULTADOS. La incidencia de FRA fue del 22,2 %, y aunque disminuyó considerablemente en los 3 últimos años del estudio, la mortalidad fue del 42,1 %, mayoritariamente en el DMO (89,5 %. Se encontró dependencia entre la insuficiencia renal y la respuesta diurética no adecuada a la fluidoterapia (51,2 %, la inestabilidad hemodinámica por más de 24 h (46,5 %, la disfunción miocárdica (43,3 % y el uso de medicamentos nefrotóxicos (42,8 %. CONCLUSIONES. La respuesta diurética no adecuada a la fluidoterapia, la inestabilidad hemodinámica por más de 24 h, la disfunción miocárdica y el uso de medicamentos nefrotóxicos incrementan el riesgo de FRA en la sepsis grave, la cual duplica la mortalidad en relación con los pacientes que conservan la función renal. No obstante, la prevención de las formas graves de sepsis y un tratamiento adecuado de ésta disminuyen la incidencia de FRA.INTRODUCTION: The aim of present research was to determine the risk factor associated with the acute renal failure (ARF in a group of children with severe sepsis seen between January, 2004 and December, 2008. METHODS: An analytical and observational study was conducted in a sample including 171 patients. There were two groups: the study-group with 138 patients with

  19. Qualidade de vida em doentes com asma

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    Lara Noronha Ferreira

    2010-01-01

    Full Text Available Resumo: Neste artigo é descrito um estudo, cujo objectivo é a medição da qualidade de vida relacionada com a saúde (QdVRS de doentes com asma e a apresentação de uma primeira aproximação aos valores normativos, com base no SF-6D, para aquele tipo de doentes. Pretende-se ainda averiguar a capacidade de medidas genéricas de medição da QdVRS distinguirem grupos em termos de características sociodemográficas. Aplicaram-se, por entrevista pessoal, as versões portuguesas do EQ-5D, do SF-6D, do AQLQ(S e do ACQ a uma amostra representativa da população portuguesa com asma.A maioria dos indivíduos não apresentou problemas significativos nas dimensões medidas, excepto na função física, onde os indivíduos reportaram limitações moderadas. Em média, os inquiridos apresentam valores de utilidade de 0,86. Os homens, os mais jovens, os solteiros, os indivíduos com habilitações literárias mais elevadas, os empregados, os indivíduos com rendimentos mais elevados e aqueles que residiam em zonas urbanas foram os que reportaram níveis de utilidade mais elevados. Por outro lado, os indivíduos que se encontravam num estádio mais avançado da doença reportaram, como era de esperar, níveis médios de utilidade inferiores aos dos que se encontravam num estádio menos grave da doença. Foram obtidos valores normativos para o SF-6D para doentes com asma por género, grupo etário, estado civil, habilitações literárias, situação profissional, local de residência e rendimento médio mensal líquido.As medidas de utilidade baseadas em preferências utilizadas neste estudo discriminam adequadamente grupos de doentes com asma, de acordo com grupos sociodemográficos. Os valores normativos obtidos podem ser usados em estudos de avaliação económica e estudos clínicos, uma vez que incorporam as preferências dos doentes

  20. Polineuropatia en un paciente crítico con malaria grave y disfunción multiorgánica

    OpenAIRE

    Brown Sotolongo, Carlos; Dias Neto, Antonio; Silva, Adelaida; Romeu Roque, Sulexi

    2014-01-01

    Introducción: la polineuropatía de paciente crítico es una "neuropatía sensitivo-motora axonal aguda que se presenta en 60-80% de los pacientes severamente enfermos, con frecuencia pude ser subclínica o poco relevante; debe sospecharse en todo paciente que tras 2 a 3 semanas de estancia en medicina intensiva se inicia entre 2 y 5 días desde el ingreso a la Unidad de Cuidados Intensivos de la Clínica Girassol o desde el comienzo de la respuesta inflamatoria sistémica. El curso de la patología ...

  1. Derrame pericárdico grave en un paciente con hipotiroidismo Severe pericardial effusion in a patient with hypothyroidism

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    María Norbelis Viamonte Tapia

    2012-12-01

    Full Text Available Se expone el caso clínico de un paciente de 40 años de edad, con aparente buena salud, atendido en el Hospital Clinicoquirúrgico Docente "Dr. Joaquín Castillo Duany" de Santiago de Cuba por presentar, desde hacía varios meses, dolor abdominal en epigastrio, no irradiado, asociado a molestia en la región anterior del tórax, dificultad para respirar, hinchazón en las piernas, decaimiento, somnolencia y dolores articulares, así como andar lento y disminución de la memoria, entre otros síntomas. Los resultados de los exámenes complementarios confirmaron que se trataba de un derrame pericárdico de causa hipotiroidea. Se indicó tratamiento sustitutivo con hormonas tiroideas (levotiroxina sódica. Evolucionó favorablemente y egresó de la institución hospitalaria, pero fue reevaluado a los 3 meses, observándose una mejoría significativa.The case of an apparently healthy 40 year-old patient is reported, who was attended in "Dr. Joaquín Castillo Duany" Clinical Surgical Hospital of Santiago de Cuba to present with epigastric abdominal pain for several months, no irradiated and associated with discomfort in anterior chest, breathing difficulty, swelling of the legs, weakness, drowsiness and joint pains, as well as slow gait, impaired memory, and other symptoms. The results of additional tests confirmed a pericardial effusion of hypothyroid cause. A replacement therapy was administered with thyroid hormones (sodium levothyroxine. He made good progress and was discharged from the hospital, but he was reevaluated at 3 months and a significant improvement was observed.

  2. Factores de riesgo de asma bronquial en niños y su relación con la severidad de las manifestaciones clínicas Risk factors of bronchial asthma in children and its relation to severity of clinical manifestations

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    Tatiana de la Vega Pazitková

    2010-06-01

    Full Text Available Introducción: el asma bronquial es una enfermedad psicosomática que constituye un importante problema de salud mundial. La prevalencia estimada en Cuba es de 8,2 %. La identificación y el control de los factores de riesgo constituyen un pilar importante en el manejo de esta entidad. Objetivos: establecer la relación entre algunos de los factores de riesgo de asma bronquial y la severidad de las manifestaciones clínicas. Métodos: se realizó un estudio descriptivo, de corte transversal, que incluyó la totalidad de los niños menores de 15 años de edad, diagnosticados como asmáticos, pertenecientes a cinco consultorios médicos del policlínico "Ana Betancourt" cuya cifra asciende a 76 pacientes, durante el período de abril de 2007 a marzo de 2008. Resultados: Los niños se agruparon según la clasificación Global Initiative for Asthma 2007 en leve intermitente:15, leve persistente:19, moderado persistente:28 y severos:14. El total de los pacientes estudiados tenía antecedentes familiares de atopia y desencadenaban las crisis de asma con los cambios climáticos. El 95 % fue sensible a inhalantes respiratorios. En el 64 % de los hogares se detectó la presencia de fumadores. Solo el 36 % de los pacientes cumplía parcialmente el tratamiento intercrisis. Conclusiones: existe relación directa entre la severidad de las manifestaciones clínicas del asma bronquial y el número de factores de riesgo que la condicionan.Introduction: bronchial asthma is a psychosomatic disease that is a significant problem of world health. In Cuba its prevalence is of 8.2 %. Its identification and the risk factor control are a very essential base in management of this entity. Objectives: to establish the relation among some risk factors of bronchial asthma and the severity of clinical manifestations. Methods: a cross-sectional and descriptive study was conducted including all children aged under 15, diagnosed with asthma seen in 5 consulting rooms of "Ana

  3. Prevalencia del asma bronquial en una población pediátrica

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    Mireya Brooks Rodríguez

    Full Text Available Introducción: la prevalencia de asma bronquial en la atención primaria, así como los factores que más inciden en ella, facilitan el tratamiento de esta enfermedad en la población pediátrica. Objetivo: determinar la prevalencia de asma bronquial en la población infantil del municipio 10 de Octubre. Métodos: se realizó un estudio poblacional descriptivo, con el propósito de determinar la prevalencia de asma bronquial en la población infantil del municipio 10 Octubre, a partir de los casos identificados con esta enfermedad. El marco muestral estuvo constituido por los pacientes en edades comprendidas entre los 0-19 años, pertenecientes al universo poblacional de 8 policlínicos del municipio. Se aplicó la distribución por grupos de edades y sexo de la población en estudio, particularizando los dispensarizados por asma. Resultados: el área de salud que aportó el mayor número de pacientes dispensarizados fue la correspondiente al Policlínico "Raúl Gómez García", con 20,4 %. El grupo etario más afectado fue el de 15 a 19 años, con 33,7 % (adolescencia tardía. La prevalencia de asma bronquial en edad infantil del municipio 10 de Octubre fue de un 15,9 %. Conclusiones: el grupo de edad 15-19 años resultó ser el más representativo, y el que, a su vez, mostró superioridad en cuanto a pacientes afectados por asma, condición que puede incrementar los riesgos en el seguimiento de la enfermedad. Existió correspondencia de la prevalencia identificada en el municipio 10 de Octubre, con los estándares nacionales e internacionales de prevalencia del asma.

  4. A asma agudizada em adultos. Revisão do tema

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    G.J. Rodrigo

    2004-09-01

    Full Text Available RESUMO: Todos os doentes com asma podem sofrer exacerbações da sua doença. Os internamentos e as idas ao serviço de urgência contribuem para uma larga proporção dos custos em cuidados de Saúde dirigidos a estes doentes. Desta forma, a prevenção, bem como o tratamento adequado dos episódios de agudização da asma, representam uma área com um elevado potencial para uma redução substancial dos custos em cuidados de Saúde. As exacerbações podem apresentar uma gravidade que varia de ligeira até potencialmente fatal. A mortalidade associa-se frequentemente a uma incapacidade para reconhecer a gravidade da exacerbação, resultando num tratamento inadequado e num atraso em referenciar o doente para a urgência hospitalar. Nesta revisão temática, os autores descrevem a epidemiologia, os custos, a fisiopatologia, a mortalidade e o tratamento da asma agudizada do adulto no serviço de urgência e na unidade de cuidados intensivos.A asma representa a 11.º diagnóstico mais frequente que motiva a ida ao serviço de urgência nos EUA, afectando sobretudo os grupos etários da adolescência e adultos jovens. As mulheres recorrem à urgência e são internadas duas vezes mais do que os homens1. Na última década tem-se assistido a um declínio do número de doentes com exacerbações graves de asma requerendo internamento em unidades de cuidados intensivos. Uma meta-análise recente atribui aos corticosteróides inalados, quando comparados com o placebo, a redução das taxas de internamento hospitalar em doentes com asma agudizada2. Provavelmente, a maior parte dos internamentos, incluindo os que requerem cuidados intensivos, podem ser evitados.Apenas cerca de 20% dos asmáticos recorreram alguma vez a um serviço de urgência. Contudo, estes doentes contribuem para mais de 80% dos custos directos totais. O internamento e as idas à urg

  5. A asma agudizada em adultos. Revisão do tema

    Directory of Open Access Journals (Sweden)

    G.J. Rodrigo

    2003-05-01

    Full Text Available RESUMO: Todos os doentes com asma podem sofrer exacerbações da sua doença. Os internamentos e as idas ao serviço de urgência contribuem para uma larga proporção dos custos em cuidados de Saúde dirigidos a estes doentes. Desta forma, a prevenção, bem como o tratamento adequado dos episódios de agudização da asma, representam uma área com um elevado potencial para uma redução substancial dos custos em cuidados de Saúde. As exacerbações podem apresentar uma gravidade que varia de ligeira até potencialmente fatal. A mortalidade associa-se frequentemente a uma incapacidade para reconhecer a gravidade da exacerbação, resultando num tratamento inadequado e num atraso em referenciar o doente para a urgência hospitalar. Nesta revisão temática, os autores descrevem a epidemiologia, os custos, a fisiopatologia, a mortalidade e o tratamento da asma agudizada do adulto no serviço de urgência e na unidade de cuidados intensivos.A asma representa a 11.º diagnóstico mais frequente que motiva a ida ao serviço de urgência nos EUA, afectando sobretudo os grupos etários da adolescência e adultos jovens. As mulheres recorrem à urgência e são internadas duas vezes mais do que os homens1. Na última década tem-se assistido a um declínio do número de doentes com exacerbações graves de asma requerendo internamento em unidades de cuidados intensivos. Uma meta-análise recente atribui aos corticosteróides inalados, quando comparados com o placebo, a redução das taxas de internamento hospitalar em doentes com asma agudizada2. Provavelmente, a maior parte dos internamentos, incluindo os que requerem cuidados intensivos, podem ser evitados.Apenas cerca de 20% dos asmáticos recorreram alguma vez a um serviço de urgência. Contudo, estes doentes contribuem para mais de 80% dos custos directos totais. O internamento e as idas à urg

  6. Tratamiento de la Enfermedad de Graves con I131: Primeros casos en la Unidad de Endocrinología Pediátrica del Hospital Nacional Cayetano Heredia, Lima-Perú: Case Report.

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    Javier Ernesto SÁNCHEZ POVIS

    2006-01-01

    Full Text Available Objetivo: Describir la respuesta al tratamiento con I131 y sus complicaciones, en niños y adolescentes con enfermedad de Graves. Material y Métodos: Se estudiaron retrospectivamente las historias clínicas de los pacientes con diagnóstico de enfermedad de Graves y que recibieron tratamiento con I131 atendidos hasta 1999 en la Unidad de Endocrinología Pediátrica del Hospital Nacional Cayetano Heredia. Se registraron datos demográficos, peso tiroideo, captación de yodo, dosis de I131 recibida y evolución clínica y de función tiroidea. Resultados: Se incluyeron 13 pacientes: 1 varón y 12 mujeres. El peso glandular promedio obtenido fue 47,56 +10,70 gramos. La dosis inicial calculada fue 3,92 + 0,95 mCi, con un total de 4,47 + 1,66 mCi y tiempo medio de seguimiento de 2,76 años. Diez pacientes recibieron 1 sola dosis, 2 pacientes dos dosis y un paciente tres dosis, remitiendo el 100%. Los pacientes que recibieron una sola dosis, mostraron remisión del cuadro en 13,13 semanas y el tiempo promedio de remisión de toda la muestra fue 24,62 semanas. La prevalencia de hipotiroidismo a los 6 meses de iniciado el tratamiento fue 66,66%, y 83,33% a las 257 semanas. Conclusión: I131 fue 100% eficaz en el tratamiento de la enfermedad de Graves de los niños y adolescentes en esta pequeña serie de casos. (Rev Med Hered 2006;17:8-14.

  7. Hubungan Derajat Asma Persisten dan Kualitas Hidup Pasien Asma Dinilai dengan Asthma Quality Of Life Questionnaire (Aqlq) di Poli Paru RSUD Dokter Soedarso Pontianak Tahun 2014

    OpenAIRE

    M Jahari Supianto

    2015-01-01

    Latar Belakang: Asma merupakan masalah kesehatan yang serius di dunia. Asma mempunyai dampak negatif pada kualitas hiduppenderitanya. Asma persisten sedang sampai berat mengakibatkan penurunan kualitas hidup penderitanya. Tujuan: Penelitian ini bertujuanuntuk mengetahui hubungan derajat asma persisten dan kualitas hidup pasien asma di Poli Paru RSUD dr. Soedarso Pontianak. Metodologi:Penelitian ini bersifat analitik dengan menggunakan pendekatan potong lintang (cross sectional). Penelitian di...

  8. Intervención psicológica grupal, basada en la aceptación y el entrenamiento en comunicación, con familiares de personas con trastorno mental grave

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    Gloria M. Roldán

    2015-10-01

    Full Text Available Se evaluó la eficacia de un programa de intervención grupal para la disminución de problemas psicológicos de familiares que conviven con pacientes con trastorno mental grave. Participaron ocho madres y un padre cuyos hijos recibían tratamiento en un Hospital de Día de Salud Mental. Se les aplicó el "Inventario de ansiedad de Beck", el "Inventario de depresión de Beck-II", la "Escala de estrés percibido", el "Cuestionario de salud SF-36", el "Inventario de estrategias de afrontamiento" y el "Inventario de aserción". Asistieron a 20 sesiones de tratamiento psicológico grupal, basado en la aceptación y el desarrollo de competencias. Tras la intervención, los participantes disminuyeron significativamente el nivel de depresión, aumentaron la conducta asertiva y el uso de estrategias de afrontamiento orientadas a la solución de problemas. Los familiares valoraron el programa como útil, aplicaron lo aprendido en su vida cotidiana, disminuyeron los niveles de malestar psicológico y la mayoría realizó acciones en la dirección de lo que valora en su vida. En conclusión, el programa fue eficaz para disminuir la depresión en los familiares y aumentar estrategias de afrontamiento adaptativas. No obstante, son necesarios más estudios para superar algunas limitaciones como el tamaño de la muestra y la ausencia del grupo control.

  9. Graves' Disease

    Science.gov (United States)

    ... 2011 survey of clinical practice patterns in the management of Graves' disease. Journal of Clinical Endocrinology and Metabolism. 2012 Dec;97( ... 30 a.m. to 5 p.m. eastern time, M-F Follow Us NIH… Turning Discovery Into ... Disease Urologic Diseases Endocrine Diseases Diet & Nutrition ...

  10. Diagnóstico de asma alérgica en consultas de alergología y neumología Diagnosis of allergic asthma in allergy and pneumology outpatient clinics

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    Luis Borderías

    2006-12-01

    Full Text Available Objetivo: Estimar la prevalencia del diagnóstico de asma alérgica en pacientes con asma persistente que acuden a consultas de alergología y neumología y describir el tratamiento clínico de estos pacientes. Métodos: Se incluyó aleatoria y retrospectivamente a 382 pacientes (12-65 años de edad con diagnóstico de asma persistente (criterios GINA que acudieron a las consultas de neumología y alergología. Se definió asma alérgica como la presencia de sensibilización a alérgenos comunes en pruebas cutáneas y/o determinaciones de inmunoglobulina (Ig E específica. Se recogió también información sobre el tratamiento recibido para el asma. Resultados: Se realizaron estudios alergológicos en el 99,5 y el 76,5% de los pacientes que acudieron a las consultas de alergología y neumología, respectivamente. Se estableció el diagnóstico de asma alérgica en el 90,6 (intervalo de confianza [IC] del 95%, 86,5-94,7 y el 46,1% (IC del 95%, 39,0-53,2 de los éstos, respectivamente. La prevalencia de diagnóstico de asma alérgica fue mayor entre los pacientes más jóvenes, los varones y los menos graves. El 14,1% de los pacientes de alergología y el 23,0% de neumología presentaban asma persistente grave. Un 24,0% de los pacientes de alergología y un 5,7% de los de neumología se trataban exclusivamente con broncodilatadores. Conclusiones: El diagnóstico de asma alérgica fue muy superior en las consultas de alergología que en las consultas de neumología. Parte de las diferencias pueden ser debidas a una mayor realización de estudios alérgicos en las consultas de alergología, aunque la mayor diferencia probablemente sea debida a los diferentes perfiles de los pacientes que llegan a cada una de estas consultas especializadas.Objectives: To estimate the prevalence of diagnosis of allergic asthma in patients with persistent asthma attending allergy or pneumology outpatient clinics and to describe the clinical management of asthma in

  11. O cuidado materno no manejo da asma infantil contribuição da enfermagem transcultural El cuidado materno en el manejo del asma infantil - contribución de enfermería transcultural Maternal care in the management of child asthma: the contributions of transcultural nursing

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    Maíra Domingues Bernardes Silva

    2009-12-01

    Full Text Available O objeto deste estudo são as práticas culturais do cuidado materno no manejo da asma infantil. Objetivos: descrever o conhecimento e o cuidado materno sobre a asma infantil e analisar o cuidado materno no manejo da asma infantil. Estudo descritivo-exploratório desenvolvido a partir de questionários e entrevistas com mães de crianças com asma, no período de setembro de 2008 janeiro de 2009. Após análise temática dos dados, emergiram três categorias: 1 Conceito e manejo da asma na visão das mães cuidadoras; 2 Asma como sofrimento e risco para a vida dos filhos; 3 Plantas medicinais, simpatias e religiosidade no cuidado do filho com asma. Concluiu-se que é importante respeitarmos a cultura das mães cuidadoras das crianças com asma, para que seus valores possam ser preservados, acomodados e reestruturados junto ao cuidado profissional.El objeto de este estudio es analizar las prácticas culturales de la atención materna en el manejo del asma infantil. Objetivos: describir el conocimiento y el cuidado de la madre en relación con el asma infantil y analizar la atención materna en el manejo del asma infantil. Estudio exploratorio-descriptivo desarrollado a partir de cuestionarios y entrevistas con madres de niños con asma, en el período comprendido entre Septiembre de 2008 y Enero del 2009. Tras el análisis temático de los datos, surgieron tres categorías: 1 Concepto y manejo del asma en la visión de las madres que cuidan de sus hijos con asma, 2 El asma como sufrimiento y riesgo para la vida de los hijos, 3 Plantas medicinales, rituales y religiosidad en el cuidado del hijo con asma. Se concluyó que es importante respetar la cultura de las madres que cuidan de los niños con asma, de modo que sus valores puedan ser preservados, acomodados y reestructurados junto a la atención profesional.The object of this study is the cultural practices of maternal care in the management of childhood asthma. Objectives: to describe both

  12. Asma e síndrome de Churg-Strauss Asthma and Churg-Strauss syndrome

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    Soloni Afra Pires Levy

    2006-08-01

    Full Text Available Relata-se o caso de uma mulher de 25 anos com síndrome de Churg-Strauss, cujos sintomas surgiram aos dezesseis anos, logo após o início do uso de contraceptivo oral. O quadro clínico evoluiu rapidamente com asma persistente grave, polipose nasal, rinite perene obstrutiva, eosinofilia periférica e tecidual, e mononeurite. A síndrome de Churg-Strauss é uma doença que exige suspeita precoce, diagnóstico preciso, tratamento agressivo e monitoramento periódico, devendo ser considerada no diagnóstico diferencial de asma persistente moderada e grave. O caso relatado chama a atenção para possível participação hormonal e surgimento em idade precoce.We report the case of a 25-year-old woman with Churg-Strauss syndrome, the symptoms of which had first appeared soon after she began taking oral contraceptive at the age of sixteen. The clinical profile evolved rapidly to severe persistent asthma, nasal polyposis, perennial obstructive rhinitis, eosinophilia (peripheral/tissue and mononeuritis. Churg-Strauss syndrome is the type of disease that demands early detection, accurate diagnosis, aggressive treatment and periodic monitoring. It should be considered in the differential diagnosis of moderate and severe persistent asthma. The case reported calls attention to possibility that there is a hormonal component and that the disease can present early onset.

  13. Dosimetric comparison between fixed and individualized activity in Graves' disease treatment with 131{sub I}; Comparacion dosimetrica entre actividad fiija y actividad individualizada en el tratamiento de la enfermedad de Graves con 131{sub I}

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    Melgar Perez, J.; Orellana Salas, A.; Santaella Guardiola, Y.; Arrocha Acevedo, J. F.

    2013-07-01

    A patient-especific method has been used to calculate the therapeutic {sup 1}'3{sup 1} I activity to administer to patients with Graves disease in order to obtain the optimal thyroid dose. The aim of this study was to analyze the dose variation in contrast to the fixed a ctivity regimen. In 30 patients, biokinetic and morfological parameters were estimated from planar scintigraphic images obtained at 4, 24 and 96 hours after injection of {sup 123} I and {sup 131} I activities were calculated to deliver 120 Gy to the thyroid. Comparative dose calculations were carried out assuming that the individual patients had been treated according to 370 MBq activity administration. Activity (or dose) was reduced by an average factor of 2.4 and up to a factor 4.9 for an individual patient. The implemen ted method seeks a balance among the accuracy of the calculations, resource consumption and patient comfort. (Author)

  14. Estratificación de riesgo en la insuficiencia aórtica grave asintomática: ¿cómo podemos identificar a los pacientes con evolución adversa?

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    Juan Krauss

    2007-01-01

    Full Text Available AntecedentesNo está determinado cómo se evalúa el riesgo en la insuficiencia aórtica (IA grave asintomática, dado que no hay consenso acerca de qué variables deben considerarse para predecir una evolución más adversa.ObjetivoEvaluar un score que incorpore variables clínicas y ecocardiográficas para identificar a pacientes con IA grave susceptibles de peor evolución.Material y métodosSe evaluaron 294 pacientes consecutivos con IA grave asintomáticos (edad media: 63 ± 7 años; 71% sexo masculino y fracción de eyección del VI [FEVI]: 64% ± 5%. Se elaboró un score basado sobre: l diámetro de fin de sístole > 24 mm/m2; 2 diámetro de fin de diástole > 36 mm/m2; 3 área del orificio regurgitante efectivo (AORE > 60 mm2; 4 diámetro de la raíz aórtica (DRA > 45 mm; 5 edad > 70 años y 6 cambio de la FEVI de reposo al ejercicio (ΔFEVI > 5%.Los puntos finales fueron: 1 sobrevida a largo plazo, 2 presencia de síntomas en el seguimiento, 3 caída de la FEVI > 5% y/o 4 cirugía valvular. El rango total del score fue de 6,5. El punto final primario fue combinado (muerte, síntomas y/o disfunción VI.ResultadosDurante un seguimiento promedio de 6,7 ± 4,2 años, 14 de 294 pacientes (4,8% fallecieron: 5 por muerte súbita, 5 por falla de bomba congestiva y 4 de causa no cardíaca. Durante el seguimiento, 88 pacientes (30% presentaron síntomas, 105 (36% disminución de la FEVI > 5% y 109 (37% fueron operados. Ciento doce (39% pacientes desarrollaron el punto final combinado.La tasa de eventos combinados (muerte, síntomas y/o caída de la FEVI con un score 3 fue del 73% ± 9%.La curva operador-receptor (ROC discriminó bien los eventos en relación con el score de riesgo: área bajo la curva de 0,93.A su vez, la tasa de cirugía valvular fue del 29% ±5% con score 3. La curva ROC discriminó bien la relación del score con la indicación de cirugía valvular: área bajo la curva de 0,96.ConclusiónEn pacientes con insuficiencia a

  15. Prevalencia y riesgos asociados con pacientes adultos con asma de 40 años o más de la Ciudad de México: estudio de base poblacional Adult asthma in Mexico City: a population-based study

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    Cecilia García-Sancho

    2012-08-01

    Full Text Available OBJETIVOS: Determinar la prevalencia de asma y la asociación entre características sociodemográficas, espirométricas, síntomas respiratorios, calidad de vida y sueño en adultos >40 años. MATERIAL Y MÉTODOS: Este informe es parte del estudio PLATINO (Proyecto Latinoamericano de Investigación en Obstrucción Pulmonar, llevado a cabo en la Ciudad de México y área metropolitana en 2003. Se utilizaron modelos de regresión logística ajustados por el diseño del estudio, donde asma fue la variable dependiente y las independientes síntomas respiratorios y características sociodemográficas y clínicas, entre otras. RESULTADOS: La prevalencia de asma diagnosticada por médico fue de 3.3% en hombres y 6.2% en mujeres. La función pulmonar disminuyó en asmáticos. En el análisis multivariado, después de ajustar por confusores potenciales, los asmáticos mostraron un mayor riesgo de ronquido más somnolencia excesiva diurna [RM=3.2 (IC95%1.4-7.4, p=0.008], y mayor frecuencia de inasistencias laborales por problemas respiratorios [RM=5.1 (IC95% 2.5-10.4, pOBJECTIVES: To determine the prevalence of asthma and the association between sociodemographic characteristics, spirometry, respiratory symptoms, quality of life and sleep in adults > 40 years. MATERIALS AND METHODS: This report is part of our study (Latin American Research Project Obstructive Pulmonary, held in Mexico City and the metropolitan area in 2003. We used logistic regression models adjusted for study design, where asthma was the dependent and independent variable respiratory symptoms, sociodemographic and clinical characteristics among others. RESULTS: The prevalence of physician-diagnosed asthma was: 3.3% in men and 6.2% in women. Decreased lung function in asthmatics was observed. In multivariate analysis, after adjusting for potential confounders, asthmatics had a higher risk of excessive daytime sleepiness more snoring [OR = 3.2 (95% CI 1.4-7.4, p= 0.008], and more frequent

  16. Esteroides inhalados: pilar fundamental en el tratamiento actual del asma

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    Roidel Pérez Pérez

    2003-06-01

    Full Text Available El asma bronquial es una de las enfermedades a las que más se enfrenta el médico cubano, y un mejor conocimiento de su fisiopatología ha provocado modificaciones en la estrategia terapéutica. Con el propósito de actualizar conocimientos referentes al tema de los antiinflamatorios esteroides y el uso de los dispositivos para la terapia inhalatoria, se realizó una revisión bibliográfica, para lo cual se consultó la información disponible en Medline, Medscape, Infomed y Doyma; se realizó además un bosquejo sobre la evolución fisiopatológica del asma y su repercusión en la terapéutica actual; se resumieron los aspectos más importantes de la terapia por vía inhalatoria, los dispositivos empleados para este fin, así como las drogas más usadas; y se concluyó que son fundamentales en el tratamiento del asma y que deben ser usados precozmente en todo asmático crónico, que los efectos adversos son mínimos usados adecuadamente, y que es de importancia capital el uso correcto de esos inhaladores.Bronchial asthma is one of the diseases that is more commonly faced by the Cuban physician, so a better knowledge of its physiopathology has brought about changes in the therapeutic strategy. With the objective of updating knowledge about steroid anti-inflammatory drugs and the use of devices for inhaling therapy, a literature review was made using data available in Medline, Medscape, Infomed and Doyma. This was accompanied by an outline of the physiopathological evolution of asthma and its effect on the present therapy. The most important aspects of inhaling therapy, the devices used as well as the most used drugs were summarized and it was concluded that inhalers are fundamental in asthma treatment, that they should be early used in chronic asthma cases, their adverse effects are minimal if adequately applied and that the correct use of these devices are of vital importance.

  17. Relación entre la severidad de las manifestaciones de asma bronquial y el cumplimiento del tratamiento intercrisis Relation between the severity of bronchial asthma manifestations and the fulfilment of the inter-crisis treatment

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    Tatiana de la Vega Pazitková

    2011-09-01

    Full Text Available INTRODUCCIÓN: En la última década han aumentado la morbilidad y la mortalidad por asma bronquial. Se estima que esta enfermedad la padecen actualmente 300 millones de personas en el mundo. En Cuba, el asma bronquial constituye también un importante problema de salud. OBJETIVO: Establecer la relación entre el cumplimiento del tratamiento en periodos intercrisis y la severidad de las manifestaciones clínicas de la enfermedad. MÉTODOS: Se estudiaron 119 pacientes con diagnóstico de asma bronquial pertenecientes al policlínico "Ana Betancourt". Para la recolección de datos se aplicaron cuestionarios de forma individual a los pacientes o a los familiares que están directamente al cuidado de estos. Los pacientes fueron agrupados según la Guía española para el manejo del asma de 2009. RESULTADOS: Se detectaron 23 pacientes asmáticos intermitentes, 42 persistentes leves, 36 persistentes moderados y 18 persistentes graves. El 95 % de los pacientes estudiados desencadenaba la crisis con inhalantes respiratorios. En el 79 % de los hogares se detectó la presencia de fumadores. Solo el 41 % de los pacientes cumplía el tratamiento correctamente en los periodos intercrisis. CONCLUSIONES: Existe una relación directa entre la severidad de las manifestaciones clínicas del asma bronquial y el no cumplimiento del tratamiento intercrisis, lo que puede condicionar la exacerbación de la enfermedad.INTRODUCTION: In past decade the morbidity and mortality from bronchial asthma have increased. This is a diseased suffered nowadays by 300 millions of persons in the world. In Cuba, the bronchial asthma is also an important health problem. OBJECTIVE: To establish the relation between the fulfilment of treatment in inter-crisis period and the severity of the clinical manifestations of this entity. METHODS: A total of 119 patients diagnosed with bronchial asthma from the "Ana Betancourt" Polyclinic were studied. In data collection authors applied individual

  18. HUBUNGAN DERAJAT ASMA PERSISTEN DAN KUALITAS HIDUP PASIEN ASMA DINILAI DENGAN ASTHMA QUALITY OF LIFE QUESTIONNAIRE (AQLQ

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    M. Jahari Supianto

    2015-05-01

    Full Text Available Abstract: The Relationship Between Degree Of Persistent Asthma And Quality Of Life In Asthma Patient That Measured By Asthma Quality Of Life Questionnaire. The aims of this study were to determine the quality of life in asthma patients in Poli Paru dr. Soedarso General Hospital Pontianak. This study uses descriptive analytic approach and cross-sectional designs. Research in the Poli Paru dr. Soedarso general hospital Pontianak from October 2014 to February 2015. The data were collected from 34 patients with asthma. This research uses Asthma Quality of Life Questionnaire (AQLQ. The data were analyzed using the Wilcoxon test. Results show that More patients with asthma in this research shows the worse quality of life. Mild persistent asthma patient’s quality of life was better than moderate persistent asthma and severe persistent asthma. There is the meaningful relationship between the degree of persistent asthma and asthma patient’s quality of life with a value of p=0,033 (p< 0.05. Keywords: the degree of persistent asthma, quality of life Abstrak : Hubungan Derajat Asma Persisten Dan Kualitas Hidup Pasien Asma Dinilai Dengan Asthma Quality Of Life Questionnaire (AQLQ. Penelitian ini bertujuan untuk mengetahui hubungan derajat asma persisten dan kualitas hidup pasien asma di Poli Paru RSUD dr. Soedarso Pontianak. Penelitian ini bersifat analitik dengan menggunakan pendekatan potong lintang (cross sectional. Penelitian di lakukan di Poli Paru RSUD dr. Soedarso Pontianak dari bulan Oktober 2014 sampai Februari 2015. Data di kumpulkan dari 34 pasien asma. Penelitian ini menggunakan Asthma Quality of Life Questionnaire (AQLQ. Data dianalisis menggunakan uji Wilcoxon. Hasil penelitian menunjukkan bahwa Pasien asma pada penelitian ini lebih banyak menunjukkan kualitas hidup buruk. Pasien asma persisten ringan kualitas hidupnya lebih baik dibandingkan asma persisten sedang dan asma persisten berat. Terdapat hubungan yang bermakna antara derajat asma

  19. Asma de difícil control en niños y adolescentes: Estrategias diagnóstico-terapéuticas Poorly controlled asthma: diagnosis and therapeutics in children and adolescents

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    Hugo Neffen

    2012-10-01

    Full Text Available El asma es una de las enfermedades crónicas más frecuentes en los niños. Si bien la mayoría de los niños con asma responden a bajas dosis de corticoides inhalados y/o antagonistas del receptor de leucotrienos, algunos de ellos permanecen sintomáticos independientemente de cualquier esfuerzo terapéutico, presentando una elevada morbilidad e inclusive mortalidad. Aunque la mayoría de los pacientes controlan los síntomas de forma adecuada, existe un grupo importante que presenta síntomas graves de la enfermedad difíciles de controlar (ADC. El objetivo de la presente revisión es discutir los aspectos clínicos, diagnósticos y terapéuticos del ACD en los menores de 18 años y su implicancia en la práctica clínica diaria.Asthma is one of the most common chronic diseases in children. While most children with asthma respond to low doses of inhaled corticosteroids and /or leukotriene receptor antagonists, some of them remain symptomatic regardless of any therapeutic effort, showing a high morbidity and even mortality. While most of the patients control symptoms adequately, there is a large group with severe symptoms of the disease and difficult to control. The aim of this review is to discuss the clinical aspects, diagnosis and treatment of poorly controlled asthma in children and adolescents and its implications in daily clinical practice.

  20. Aplicación de la teoría de Florence Nightingale a un anciano con asma bronquial Application of Florence Nightingale’s theory to an old patient suffering from bronchial asthma

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    Kety Bernardes Carballo

    2012-08-01

    Full Text Available En la historia de la Enfermería, existieron grandes teóricas que aportaron fundamentos para la atención de enfermería a los pacientes con enfermedades crónicas, donde un entorno desfavorable puede constituir un factor de riesgo para desencadenar una crisis de la enfermedad; esto fue descrito por la teoría de Florence Nightingale, que reconocía especial interés al entorno como factor esencial para la salud de las personas. Se realizó un estudio descriptivo, con el objetivo de relacionar la teoría de Florence Nightingale a una situación de caso real de un adulto mayor asmático, perteneciente al consultorio #1 del Policlínico Universitario "Pedro Borrás Astorga" de Pinar del Río en enero de 2012. La información fue obtenida a través de la visita domiciliaria. Se interrogó a la paciente, estudió su historia clínica, y realizó un estudio del epistolario de Nightingale, así como han sido revisadas fuentes secundarias de teóricas más recientes, quienes han desarrollado sus propias teorías y modelos a partir de la lógica del pensamiento nightingaleano. En el hogar del paciente se observaron algunas alteraciones del entorno, que fueron identificadas por Florence Nightingale como elementos que inciden en la salud del individuo. Se brindó una educación para la salud a la paciente asmática en aras de mejorar las condiciones ambientales para de esta forma evitar la aparición de próximas crisis de su enfermedad de base.In the history of nursing specialty existed a great number of theories that contributed to the new basics of the nursing care in patients suffering from chronic diseases, where unfavorable environments can constitute a risk factor that can trigger for a disease worsening; this was described by the theory of Florence Nightingale, who recognized the special significance of the environment as an essential factor influencing on people’s health. A descriptive study aimed at relating the theory of Florence Nightingale

  1. Investigação de fatores associados à asma de difícil controle Investigation of factors associated with difficult-to-control asthma

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    Ana Carla Sousa de Araujo

    2007-10-01

    Full Text Available OBJETIVO: Pesquisar a freqüência dos fatores associados à asma de difícil controle. MÉTODOS: Foram selecionados pacientes com diagnóstico de asma grave do ambulatório de asma do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto. Os pacientes foram classificados em dois grupos: asma grave controlada e asma grave de difícil controle. Após nova tentativa de otimização do tratamento para o grupo de difícil controle, foram aplicados questionário e investigação complementar de fatores associados, como exposição ambiental domiciliar e ocupacional, tabagismo, fatores sociais, rinossinusite, doença do refluxo gastroesofágico (DRGE, apnéia obstrutiva do sono, insuficiência cardíaca congestiva (ICC, embolia pulmonar, fibrose cística, disfunção de cordas vocais, deficiência de alfa-1 antitripsina e vasculite de Churg-Strauss. RESULTADOS: Foram selecionados 77 pacientes com asma grave, dos quais 47 apresentavam asma de difícil controle, sendo 68,1% do sexo feminino, idade média de 44,4 anos (±14,4 e volume expiratório forçado no primeiro segundo de 54,7% (±18,3%. Dos diagnósticos encontrados em associação à asma de difícil controle, o mais freqüente foi a pouca adesão ao tratamento (68%. Outros foram as más condições ambientais (34% e ocupacionais (17%, rinossinusite (57%, DRGE (49%, apnéia obstrutiva do sono (2%, ICC (2% e tabagismo (10%. Em todos os casos, pelo menos um desses fatores concomitantes foi diagnosticado. CONCLUSÕES: O fator mais freqüente associado à asma de difícil controle nos indivíduos estudados é a pouca adesão à medicação prescrita. A investigação de co-morbidades é imperativa na avaliação de pacientes com esta forma da doença.OBJECTIVE: To determine the prevalence of factors associated with difficult-to-control asthma. METHODS: Patients with severe asthma were selected from the outpatient asthma clinic of the Ribeirão Preto School of Medicine Hospital das Cl

  2. Eficacia de vibraciones transtorácicas más in-exuflación mecánica versus:técnicas manuales para tos asistida en pacientes pediátricos con parálisis cerebral grave o profunda

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    Vergara Lozano, Pedro

    2014-01-01

    Las infecciones respiratorias recurrentes son frecuentes en la Parálisis Cerebral (PCI). La tos asistida manual (TAM) y mecánica (TM) persigue preservar las funciones del aparato respiratorio. Objetivo:. Evaluar la eficacia del tratamiento con vibraciones transtorácicas más insuflación-exuflación mecánica frente a las técnicas manuales, para inducir tos asistida en pacientes pediátricos con PCI grave o profunda. Método: 40 niños con PCI hospitalizados por infecciones respiratorias con edad me...

  3. Características clínicas e prognóstico em pacientes com asma quase fatal em Salvador, Bahia Clinical characteristics and prognosis in near-fatal asthma patients in Salvador, Brazil

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    Eduardo Vieira Ponte

    2011-08-01

    Full Text Available OBJETIVO: Determinar a frequência de asma quase fatal em um grupo de pacientes com asma grave, assim como as características clínicas e o prognóstico desses pacientes em um ano de seguimento. MÉTODOS: Estudo prospectivo envolvendo 731 pacientes de baixa renda com asma grave tratados em um ambulatório de referência para asma na cidade de Salvador (BA. Os pacientes realizaram espirometria na admissão do estudo, receberam medicações para asma e foram monitorizados quanto à frequência de exacerbações durante o seguimento. Uma subamostra de 511 pacientes também respondeu questionários de sintomas e de qualidade de vida relacionada a asma. RESULTADOS: Dos 731 pacientes estudados, 563 (77% eram do sexo feminino, com mediana de idade de 47 anos, e 12% não eram alfabetizados. A maioria dos pacientes apresentava rinite, e 70 (10% relataram asma quase fatal antes da admissão. Desses 70 pacientes, 41 (59% relataram terem sido intubados previamente. Os pacientes com asma quase fatal na admissão eram mais propensos a exacerbações de asma durante o acompanhamento e tiveram menor resposta ao tratamento do que aqueles sem asma quase fatal. Os resultados dos questionários no final do acompanhamento foram semelhantes nos dois grupos de pacientes. CONCLUSÕES: A frequência de asma quase fatal foi alta nesta população de pacientes com asma grave e de baixa renda. Os pacientes com histórico de asma quase fatal tiveram um pior prognóstico que aqueles sem esse histórico, embora tenham recebido o mesmo tratamento. Curiosamente, a intensidade dos sintomas e a qualidade de vida no final do estudo foram semelhantes entre os dois grupos de pacientes.OBJECTIVE: To determine the frequency of near-fatal asthma in a group of severe asthma patients, as well as the clinical characteristics and prognosis of these patients within a one-year follow-up period. METHODS: A prospective study involving 731 low-income patients with severe asthma treated at a

  4. Fluidoterapia de reanimación en pacientes con trauma grave: ¿Necesita cambiarse? Resuscitation fluid therapy in patients with severe trauma: Is a change necessary?

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    Mario Miguel Morales Wong

    2006-12-01

    Full Text Available El acceso venoso en los pacientes politraumatizados ha sido tradicionalmente una medida de suma importancia que permite la administración de líquidos, analgésicos, anestésicos y drogas reanimadoras. Convencionalmente en un paciente exanguinado, la administración vigorosa de cristaloides o coloides estuvo encaminada a restablecer de forma «empecinada» los valores de tensión arterial cercanos a la normalidad, en un intento por lograr la oxigenación tisular adecuada desde el preoperatorio. Sin embargo, se ha demostrado que tal estrategia de reanimación en este tipo de paciente aumenta la morbilidad y mortalidad de este debido a las graves anormalidades metabólicas que provoca, entre ellas la hipotermia, la acidosis, la coagulopatía y el resangrado de las lesiones vasculares previamente autocontroladas por los mecanismos fisiológicos de la coagulación. Hacemos una revisión de la literatura que refleja los relativamente nuevos puntos de vistas en la fluidoterapia de reanimación del paciente politraumatizado exanguinado

  5. 70. Toma de decisiones en pacientes con estenosis aórtica grave ante las nuevas alternativas terapéuticas

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    A. Donado Miñambres

    2010-01-01

    – Así pues, teniendo en cuenta las discrepancias actuales entre los distintos estratificadores de riesgo quirúrgico, cada centro debería considerar su propia estrategia de acuerdo con el tipo de población intervenida.

  6. A asma e os seus diagnósticos diferenciais Asthma and its differential diagnoses

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    Alexandra Bento

    2009-11-01

    Full Text Available A aspergilose broncopulmonar alérgica (ABPA ocorre em doentes não imunocomprometidos e é uma patologia de hipersensibilidade induzida pelo Aspergillus5. Estima-se que esteja presente em cerca de 7-14% dos casos de asma crónica corticodependente e o no mesmo número de casos de fibrose quística. A maioria das ABPA são identificadas pela 30-50.ª décadas de vida, mas podem surgir na infância¹. O diagnóstico baseia-se na presença de uma combinação de critérios clínicos, biológicos e radiológicos5. A doença apresenta-se com largo espectro de gravidade, pode ser reconhecida precocemente e tratada agressivamente, impedindo a sua progressão para um estádio de doença grave e debilitante requerendo transplante pulmonar¹. Os autores relatam o caso de uma doente de 41 anos, com antecedentes de asma alérgica desde a infância. Uma asma grave, de difícil controlo e com recurso a corticoterapia sistémica por longos períodos.Allergic bronchopulmonary aspergillosis (ABPA occurs in immunocompetent patients and belongs to the Aspergillus5 induced hypersensitivity disorders. It is estimated that ABPA complicates approximately 7-14% of cases of chronic steroid-dependent asthma and the same amount of cases of cystic fibrosis. A diagnosis of ABPA is based on a combination of clinical, biological and radiology criteria5. There is a broad spectrum of disease severity. Early detection and aggressively management will impede progressive lung damage to a severe and debilitating disease requiring lung transplantation¹. The authors describe the case of a 41 year-old female with a history of allergic asthma from childhood¹. It was a severe, difficult to control asthma treated with systemic corticosteroids for long periods.

  7. Registro de pacientes con esclerodermia. Desarrollo de una herramienta clínica para la detección precoz de úlceras digitales complicadas e isquemia grave.

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    Sánchez Quirós, Belén

    2017-01-01

    La esclerosis sistémica es una enfermedad rara del tejido conectivo que se caracteriza por el engrosamiento de la piel y la afectación de diferentes órganos internos. El fenómeno de Raynaud (FR) suele ser la primera manifestación apareciendo en la mayoría de los pacientes y provocando isquemia. Sin embargo, las úlceras digitales (UD) solo están presentes en el 30%. La detección precoz de UD incipientes, con la consiguiente aplicación de un tratamiento adecuado, evitará pérdida de la capacidad...

  8. Poliartritis y tenosinovitis grave por Streptococcus agalactiae en un paciente con hipoesplenia funcional Severe polyarthritis and tenosynovitis caused by Streptococcus agalactiae in a patient with functional hyposplenia

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    Domingo C. Balderramo

    2002-08-01

    Full Text Available La artritis por Streptococcus agalactiae es infrecuente. No conocemos publicaciones de casos sobre la afección tendinosa por este microorganismo. Se presenta una mujer de 46 años que consultó por fiebre, poliartralgias, mialgias, diarrea y vómitos. Como antecedentes presentaba carcinoma papilar de tiroides e hipoesplenia funcional. Al examen se encontraba hemodinámicamente inestable, febril, con artritis de mano izquierda, muñecas, codos, hombro derecho y tobillo izquierdo. Presentaba tenosinovitis en ambos pies y en la mano izquierda. Los hemocultivos y el cultivo de la bursa olecraniana derecha fueron positivos para S. agalactiae. La ecografía mostró signos de tenosinovitis del tibial anterior izquierdo. Completó 20 días de tratamiento endovenoso con cefazolina y 12 días de cefuroxima oral. El cuadro articular revirtió completamente en 60 días. El Streptococcus agalactiae puede causar, en forma infrecuente, un síndrome de poliartritis, tenosinovitis y fiebre similar al producido por la infección gonocócica.Cases of arthritis caused by Streptococcus agalactiae are infrequent and in our knowledge there are no case reports of tenosynovitis caused by S. agalactiae. A 46-year-old woman presented with fever, polyarthralgia, myalgia, diarrhea and vomiting. She had a history of papillary thyroid carcinoma and functional hyposplenia. She was febrile, with arthritis in hands, wrists, elbows, right shoulder and left ankle joints, and presented tenosynovitis in both feet and left hand. Blood and right olecranon bursa sample cultures were positive for S. agalactiae. An ultrasound scan made at the musculus tibialis anterior of left foot revealed signs of tenosynovitis. She was treated with intravenous cefazolin for 20 days and oral cefuroxime for 12 days. The joint involvement completely subsided in 60 days. Streptococcus agalactiae can cause, infrequently, a polyarthritis and tenosynovitis syndrome similar to disseminated gonococcal

  9. Factores asociados al asma en los niños y adolescentes de la zona rural de Navarra (España

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    Itsaso Elizalde-Beiras

    2018-06-01

    Full Text Available Resumen: Objetivos: Conocer los factores asociados al asma y síntomas relacionados con asma en la población infantil y adolescente en la zona rural de Navarra (España a través de la validación del cuestionario ISAAC. Participantes y métodos: Estudio transversal mediante la realización del cuestionario ISAAC y variables adicionales por 797 niños y adolescentes, a través del cual se obtuvieron datos de prevalencia sobre síntomas de asma y factores asociados sin realizar ninguna prueba diagnóstica adicional. Emplazamiento: Marco de atención primaria. A través de las zonas básicas de salud se hizo la selección de la muestra y en los centros educativos de dichas zonas se realizó el cuestionario. Mediciones y resultados: El análisis estadístico se hizo a través de regresión logística, chi cuadrado e intervalo de confianza al 95%. La prevalencia asma referida es del 11,7% en niños y del 13,4% en adolescentes. En cuanto a los factores relacionados, según los valores de OR destacan: OR = 9,5 entre sibilancias y asma, y OR = 3,5 entre rinitis recientes y asma. Respecto a las sibilancias recientes, hallamos un OR = 11,5 entre despertares y sibilancias recientes, y un OR = 3,4 entre rinitis recientes y sibilancias recientes. Conclusiones: El asma referida es una enfermedad prevalente ligeramente superior en la adolescencia y la población femenina de los escolares de la zona rural. Rinitis y otros síntomas de asma están relacionados con el asma y con las sibilancias, así como la utilización de los servicios de urgencias en el caso del asma y la bronquitis con las sibilancias. Abstract: Objectives: To determine the factors associated with asthma and asthma-related symptoms in children and adolescents in rural areas of Navarre (Spain. Participants and methods: A cross-sectional study using the International Study of Asthma and Allergies in Childhood (ISAAC questionnaire, as well as additional variables, was conducted on 797

  10. Atresia biliar: una enfermedad grave

    OpenAIRE

    Ramonet, Margarita; Ciocca, Mirta; Alvarez, Fernando

    2014-01-01

    La atresia biliar es una grave enfermedad que se manifiesta en los recién nacidos, y se desconoce su causa. La inflamación y destrucciónprogresiva de los conductos biliares conducen a la aparición de ictericia, coluria y acolia entre la segunda y sexta semana de vida. Como existen múltiples causas de colestasis neonatal en esta etapa de la vida, es necesario realizar un diagnóstico y derivación precoz para ofrecer un tratamiento quirúrgico, con el fin de restablecer el flujo biliar. Alrededor...

  11. The feasibility of vocational rehabilitation in subjects with severe mental illness Factibilidad de la rehabilitación vocacional en personas con enfermedades mentales graves

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    Stefan Watzke

    2008-01-01

    Full Text Available Vocational rehabilitation represents an important element within the mental health care system. To ensure the success of rehabilitation, programs of varying degrees of complexity are needed in order to meet patients’ abilities and needs. Rehabilitation success must be examined multidimensionally and not be reduced to the mere integration into competitive employment. Success is also represented by progress in the level of vocational integration, strengthening of work capabilities, the improvement of the functional level, and in a better quality of life. The patient’s need for rehabilitation has to be recognized as early as possible to shorten the duration of the patient’s disintegration and to avoid stagnation periods. Rehabilitation needs to start in the clinic; with psychiatric help sustained during the rehabilitation process to prevent illness exacerbation and premature program termination. The patient’s development regarding his or her functional level, work capability, and subjective wellbeing needs to be evaluated throughout the program to consistently monitor the patient’s individual needs and abilities and to ensure appropriate support. Training for cognition and social skills should be integrated into rehabilitation programs to compensate individual deficits.La rehabilitación vocacional representa un importante elemento dentro del sistema del cuidado de la salud mental. Con el fin de asegurar el éxito de la rehabilitación y para satisfacer las necesidades y habilidades de los pacientes hacen falta programas de diversos grados de complejidad. El resultado de la rehabilitación debe examinarse de manera multidimensional y no reducirse tan sólo a la integración al empleo competitivo, pues el éxito se ve reflejado asimismo por el avance en el nivel de integración vocacional, el fortalecimiento de las capacidades para el trabajo, la mejora del nivel de funcionamiento y una mejor calidad de vida. Las necesidades de

  12. El papel del músculo liso bronquial y los nervios en la fisiopatología del asma bronquial

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    María Victoria Picó Bergantiños

    2001-02-01

    Full Text Available Gran cantidad de evidencia se ha recopilado en los últimos años con relación a la naturaleza inflamatoria del asma bronquial, lo que ha traído como consecuencia la revisión obligada de aspectos importantes de su fisiopatología, y entre estos aspectos consideramos de sumo interés el papel que juega el músculo liso bronquial y los nervios en la génesis y desarrollo de esta enfermedad. La proteína quinasa C (PKC está involucrada en la contracción mantenida del músculo liso bronquial in vitro, y puede por tanto ser de particular importancia en pacientes con asma crónica. El incremento del engrosamiento del músculo liso de las vías aéreas es otra característica llamativa en algunos pacientes con asma, y puede tener lugar tanto en las partes proximales como distales de las vías aéreas. La tos y la "apretazón" en el pecho son síntomas comunes en el asma y probablemente estos síntomas están mediados por la activación de aferentes nerviosos. Finalmente se expresan las posibles interrogantes futuras que pudieran definir las investigaciones en el campo de la fisiopatología del asma en lo relacionado con el músculo liso bronquial y la inervación pulmonarThe great deal of evidence that has been collected for the last years in connection with the inflammatory nature of bronchial asthma have led us to make an obliged review of some important aspects of its physiopathology. Among these aspects, we consider it is very interesting the role played by the airway smooth muscle and nerves in the genesis and development of this disease. The protein kinase C (PKC is involved in the maintained contraction of the airway smooth muscle in vitro and it may be of particular significance in patients with chronic asthma. The thickening of the airway smooth muscle is another characteristic of some patients with asthma and it may occur in the proximal parts and in the distal parts of the airways. Cough and chest "squeeze" are common symptoms in asthma

  13. Nutrición enteral total vs. nutrición parenteral total en pacientes con pancreatitis aguda grave Total enteral nutrition vs. total parenteral nutrition in patients with severe acute pancreatitis

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    M. Casas

    2007-05-01

    Full Text Available Objetivo: comparar la eficacia de la instauración precoz de nutrición enteral total (NET frente a nutrición parenteral total (NPT en pacientes con pancreatitis aguda grave (PAG. Métodos: estudio prospectivo aleatorio. Se incluyeron consecutivamente 22 pacientes con PAG aplicando los criterios APACHE II, valores de PCR y graduación de Balthazar en la TC. El grupo I (n = 11 recibió NPT y el grupo II (n = 12 NET. Se valoró la respuesta inflamatoria (PCR, TNF-alfa, IL-6, las proteínas viscerales (pre-albúmina, albúmina, la tasa de complicaciones (síndrome de respuesta inflamatoria sistémica, fallo multiorgánico, infecciones, las intervenciones quirúrgicas, la estancia hospitalaria y la mortalidad. Resultados: no hubo diferencias significativas en los primeros 10 días entre los dos grupos en la evolución de los criterios APACHE II, en las concentraciones de PCR, TNF-alfa e IL-6 ni tampoco en los valores de pre-albúmina y albúmina. Siete pacientes del grupo I presentaron complicaciones graves frente a 4 del grupo II. Requirieron intervención quirúrgica 3 pacientes del grupo I. La estancia hospitalaria fue similar en los dos grupos. Dos pacientes del grupo I fallecieron. Conclusiones: se ha observado una tendencia a una mejor evolución de los pacientes con PAG que utilizaron NET frente a los que utilizaron NPT.Objective: to compare the efficacy of early total enteral nutrition (TEN vs. total parenteral nutrition (TPN in patients with severe acute pancreatitis (SAP. Methods: a total of 22 consecutive patients with SAP were randomized to receive TPN (group I or TEN (group II. SAP was defined applying APACHE II score, C-reactive protein (CRP measurements and/or Balthazar CT scan score. Acute inflammatory response (CRP, TNF-alpha, IL-6, visceral proteins (pre-albumin, albumin, complications (systemic inflammatory response syndrome, multiorgan failure, infections, surgical interventions, length of hospital stay and mortality were

  14. Genetics Home Reference: Graves disease

    Science.gov (United States)

    ... Email Facebook Twitter Home Health Conditions Graves disease Graves disease Printable PDF Open All Close All Enable Javascript to view the expand/collapse boxes. Description Graves disease is a condition that affects the function of ...

  15. Características de los casos graves hospitalizados por gripe pandémica (H1N1 2009 en Cataluña

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    Pere Godoy

    2011-01-01

    Full Text Available Fundamentos. Las pandemias de gripe pueden comportar una mayor gravedad. El objetivo fue determinar las características de los casos graves hospitalizados de gripe pandémica en Cataluña y estudiar factores de riesgo de ingreso en CI. Métodos: e realizó un estudio epidemiológico observacional y prospectivo de los casos nuevos de gripe pandémica hospitalizados por su gravedad en el período: junio del 2009 hasta mayo del 2010. e solicitó a los centros sanitarios la declaración de los casos que cumplieron la definición de caso grave y en los que se confirmó la presencia del virus pandémico. Mediante una encuesta epidemiológica se recogió información sobre variables demográficas, clínica, factores de riesgo, tratamiento y evolución clínica. Las diferencias entre los casos en CI respecto al resto de casos graves se estudiaron con la odds ratio ajustada (ORa mediante un modelo de regresión logística no condicional. Resultados: e detectaron 773 casos graves de gripe pandémica; 465 (60,2% presentaron al menos un factor de riesgo y los más prevalentes fueron: embarazo 19 (13%, asma 87 (12%; enfermedad pulmonar obstructiva crónica 87 (11,4% y cardiopatías 80 (10,5%. Precisaron ingreso en una unidad de cuidados intensivos 293 pacientes (37,9%. Los factores asociados al ingreso en CI fueron la obesidad IMC>40 (ORa=2,5; IC 95% 1,4-4,5 y la enfermedad hepática crónica (ORa=2,3; IC 95% 1,1-4,8. Conclusiones: e confirma la alta prevalencia de embarazo, enfermedades respiratorias crónicas, diabetes y obesidad entre los casos graves. La obesidad mórbida se comporta como un factor de riesgo de ingreso en CI y por ello debe ser un indicador de vacunación antigripal.

  16. Hallazgo de Lophomonas sp. en secreciones del tracto respiratorio de niños hospitalizados con enfermedad pulmonar grave Lophomonas sp. in respiratory tract secretions in hospitalized children with severe lung disease

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    Rito Zerpa

    2010-12-01

    Full Text Available Lophomonas sp. es un parásito habitual del tracto intestinal de las cucarachas y que no es reconocido como patógeno humano. Sin embargo, en la literatura mundial existen escasos reportes de Lophomonas sp. en secreciones del tracto respiratorio en pacientes con enfermedad pulmonar grave, principalmente en adultos. Presentamos evidencias de Lophomonas sp. en el tracto respiratorio inferior de niños atendidos en el centro de referencia nacional de enfermedades pediátricas de Lima, Perú, en el periodo 2009-2010. Se encontró seis casos, 4/23 provenientes de muestras de lavado broncoalveolar y 2/794 muestras de aspirado traqueal de niños. Cinco de ellos tuvieron neumonía y uno atelectasia, cuatro estuvieron en la unidad de cuidados intensivos. Es necesario conocer más sobre la presencia de este organismo en infecciones respiratorias así como su rol patogénico real.Lophomonas sp. is a habitual parasite of the intestinal tract of the cockroaches and that is not recognized as pathogenic human being. Nevertheless, in the world literature are few reports of Lophomonas sp. in respiratory tract secretions in patients with severe pulmonary disease, mostly in adults. We present evidences of Lophomonas sp. in the respiratory low tract of children attended in the national reference center of paediatric diseases of Lima, Peru, in the period 2009- 2010. We found six cases, 4/23 from broncoalveolar lavage and 2/794 from tracheal aspirate samples of children. Five of them had pneumonia and one atelectasis, four were hospitalized in the intensive care unit. Increase knowledge about the presence of this organism in respiratory infections is needed, as its real pathogenic role.

  17. La inclusión educativa de alumnos con discapacidades graves y permanentes en la Unión Europea. [Educational inclusion of students with severe and permanent disabilities in the European Union

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    López-Torrijo, Manuel

    2009-06-01

    Full Text Available This article presents a comparative study of the care of students with severe and permanent educational needs in the six EU countries with greater rates of educational inclusion, (Italy, Greece, Portugal, Norway, Cyprus and Iceland. Such study has been done bearing in mind the following indicators: Analysis of educational needs, identification of deficit, schooling of students in Specific Centres for Special Education, legislative frame, responsibility for schooling and rendering of services, frame and models of schooling, state and functions of Specific Centres of Special Education, curricula of the inclusion, Human resources, family role and funding. From the aforementioned lines are deduced the trends in policies and educational practices carried out are followed. Conclude the necessary changes for the improvement of the future educational educational inclusion. Este artículo presenta un estudio comparado de la atención realizada a los alumnos con discapacidades graves y permanentes en los seis países de la UE que presentan mayores índices de inclusión educativa (Italia, Grecia, Portugal, Noruega, Chipre e Islandia. Dicho estudio está realizado teniendo en cuenta los siguientes indicadores: concepción de las necesidades educativas especiales, identificación de los déficit, alumnado escolarizado en Centros Específicos de Educación Especial, marco legislativo, responsabilidad de escolarización y prestación de servicios, modelo y modalidades de escolarización, estado y funciones de los Centros Específicos de Educación Especial, currículo de la inclusión, recursos humanos, papel de las familias y financiación. De ahí se deducen las tendencias en las políticas y las prácticas educativas realizadas y se concluyen los cambios necesarios para mejorar la inclusión educativa en un futuro.

  18. Miastenia grave y miastenia grave ocular

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    Rosa María Naranjo Fernández

    Full Text Available La miastenia grave es una enfermedad caracterizada por debilidad y fatiga de los músculos voluntarios debido a una trasmisión anómala a nivel de la unión neuromuscular. La prevalencia es aproximadamente de 5 casos/100 000 personas. La miastenia grave puede ser bulbar, ocular o generalizada.Existen formas clínicas en la infancia como son la miastenia neonatal transitoria, la miastenia congénita y la miastenia juvenil. Los músculos oculares, faciales y bulbares son los más frecuentes afectados por la enfermedad. Cuando los síntomas se limitan a la musculatura cercana al ojo se denomina miastenia grave ocular. Una vez el oftalmólogo diagnostica o sospecha la miastenia grave, un neurólogo generalmente dirige la comprobación y tratamiento. El papel del oftalmólogo continúa siendo importante, además de chequear la motilidad y disfunción palpebral y proporcionar el alivio sintomático para estos desórdenes, debe estar alerta a la posibilidad de ambliopía.

  19. Crisis aguda de Asma Bronquial. Diagnóstico y tratamiento estandarizado

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    Anelia de la Caridad Rojas-Pérez

    2013-01-01

    Full Text Available Se realizó un estudio prospectivo de intervención en 150 pacientes con diagnóstico de Asma Bronquial que acudieron con crisis aguda al Servicio de Urgencias del Hospital Pediátrico de Holguín, de Enero del 2009 hasta Diciembre del 2010; para evaluar la evolución de los mismos después de la aplicación de Guías de Buenas Prácticas. Se aplicó tratamiento a los pacientes según lo establecido, observando su respuesta. Predominó el grupo de 4 a 8 años del sexo masculino, el 52 % de los pacientes presentaron crisis ligeras, buena respuesta al uso de broncodilatadores en aerosol, se aplicó la Prednisona por vía oral en la mayoría de los casos que lo requirieron, el 68,7 % realizó tratamiento domiciliario con respuestas controladas y solo en el 31,3 % se decidió ingreso hospitalario lo que permitió arribar a la siguiente conclusión: Con la aplicación de Guías de Buenas Prácticas Clínicas par a el manejo de la exacerbación aguda del Asma Bronquial se logró una clasificación adecuada de la severidad de la misma, buena respuesta a los tratamientos utilizados y disminución de los ingresos hospitalarios.

  20. Características sistémicas y orales de la nefrolitiasis bilateral y asma en niños - Reporte de caso

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    Carmen de la Luz Ayala Escandón

    2016-01-01

    Full Text Available Introducción. La nefrolitiasis es una enfermedad caracterizada por la formación de cálculos en el riñón, de gran incidencia y alta recurrencia, considerada rara en niños. Cuando no se trata evoluciona con altos índices de complicaciones. El asma es una enfermedad crónica inflamatoria de las vías respiratorias y ocasiona una importante morbilidad y mortalidad. Metodología: Se informa del caso de una niña de 4 años diagnosticada con nefrolitiasis bilateral y asma, referida para atención odontológica. Se incluye: Revisión bibliográfica de las patologías base, metodología clínica utilizada en el estado de salud general y oral, pre y post tratamiento dental. Conclusiones: En concordancia con lo descrito por diversos autores, los niños con nefrolitiasis bilateral y asma tienen un mayor índice de caries, higiene oral deficiente, una alta susceptibilidad a otras infecciones como candidiasis y a menudo exhiben defectos del esmalte, mucosas cianóticas, malposición dental y xerostomía. La prevención primaria es decisiva, una higiene dental apropiada, revisiones odontológicas habituales, así como el uso de broncodilatadores constituyen elementos significativos sobre todo en pacientes de alto riego.

  1. Control del asma en pacientes que acuden a consulta de atención primaria en España (estudio ACTIS

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    Eduardo Calvo

    2017-12-01

    Full Text Available Resumen: Objetivo: Evaluar la prevalencia de asma no controlada (puntuación < 20 en el Asthma Control Test [ACT] en la práctica clínica habitual en España. Diseño: Estudio observacional, transversal. Emplazamiento: Cincuenta y ocho centros de atención primaria de 13 comunidades autónomas. Participantes: Pacientes asmáticos atendidos por consulta administrativa sin empeoramiento subjetivo (grupo A o por empeoramiento de sus síntomas (grupo B. Mediciones principales: Características sociodemográficas (edad, sexo, educación y tabaquismo, nivel de gravedad del asma según el médico, terapia actual para el asma, enfermedades concomitantes, utilización de recursos sanitarios (consultas, hospitalizaciones y urgencias, absentismo laboral y escolar, puntuación ACT y adherencia al tratamiento. Resultados: Se incluyeron 376 pacientes del grupo A y 262 del grupo B. El 59% eran mujeres, edad media de 45 años, 21% fumadores y tiempo medio de evolución del asma 8,9 años. El 87% usaban agonistas beta-2 de corta duración, el 62% beta-2 de larga duración asociados con corticoides inhalados y el 13,8% corticoides inhalados regularmente. Se observó mal control del asma en el 75,6% del grupo B y en el 23,4% del grupo A; solo el 5,3% del grupo A presentaba control total (ACT = 25. Un peor control del asma se asociaba significativamente con mayor duración de la enfermedad y mayor uso de recursos. Conclusiones: La prevalencia de asma no controlada en pacientes que acuden a la consulta de atención primaria por empeoramiento de sus síntomas continúa siendo muy elevada. El mal control del asma se asocia con un elevado uso de recursos e impacta significativamente en la carga de la enfermedad. Abstract: Objective: To assess prevalence of non controlled (ACT- Asthma Control Test < 20 asthma in real world clinical practice in Spain. Design: Observational, cross-sectional study. Location: 58 primary care centers from 13 Autonomous Communities

  2. O impacto da genética na asma infantil

    OpenAIRE

    Pinto,Leonardo A.; Stein,Renato T.; Kabesch,Michael

    2008-01-01

    OBJETIVO: Apresentar os resultados dos estudos mais importantes e recentes sobre a genética da asma. Estes dados devem auxiliar os clínicos gerais a compreender o impacto da genética sobre este distúrbio complexo e como os genes e polimorfismos influenciam a asma e a atopia. FONTES DOS DADOS: Os dados foram coletados do banco de dados MEDLINE. Os estudos de associação genética foram selecionados do Genetic Association Database, um repositório de estudos de associação genética de doenças e dis...

  3. Hubungan Kadar Vitamin C Plasma dengan Serangan Asma pada Anak

    Directory of Open Access Journals (Sweden)

    Azwar Aruf

    2016-11-01

    Hasil. Karakteristik subyek, antara lain umur, jenis kelamin, riwayat kontak hewan peliharaan, riwayat kontak tungau debu rumah, perokok pasif, alergi makanan, infeksi saluran pernapasan, kadar vitamin C plasma. Analisis bivariat dilakukan dengan uji kemaknaan (nilai p<0,05, dan rasio Odds. Kadar vitamin C plasma kelompok asma dalam serangan dan tidak dalam serangan tidak berbeda bermakna dengan nilai p=0,77 dan rasio Odds 1,18 (IK95%: 0,32;3,64. Infeksi pernapasan merupakan faktor risiko serangan asma yang bermakna dengan nilai p=0,006 dan rasio Odds 3,6 (IK 95% 1,41;9,19.

  4. Association of Papillary Thyroid Carcinoma and Graves' Disease. Unexpected Development and Efficiency of Ablative Dose with Recombinant Human Thyrotropin (rhTSH); Asociación de carcinoma papilar de tiroides y enfermedad de Graves. Inesperada evolución y eficacia de la dosis ablativa con tirotrofina recombinante humana (rhTSH)

    Energy Technology Data Exchange (ETDEWEB)

    Pacenza, N. A.; Groppo, N. [Centro Médico “Enrique Tortosa”, Consultorio de Endocrinología, Buenos Aires (Argentina); Guibourg, H. C. [Sigma Imágenes Médicas S.A., Servicio de Medicina Nuclear, Buenos Aires (Argentina)

    2013-07-01

    22-year-old obese man. Highlights: 1) The importance of initial US exploration in a patient with GD, 2) Residual neoplastic lymph node tissue after 2 S, performed by an experienced surgeon, with enough functioning tissue to prevent a significant elevation of TSH and allow I{sup 131} ablative therapy, 3) Tumor local aggressiveness shown by adjacent tissues and lymph node infiltration, 4) Failure to identify residues in the neck by CT and US; instead, effectiveness of the neck MRI without contrast and {sup 99m}Tc thyroid scan, 5) Effective use of ablative radioiodine therapy with rhTSH. (authors) [Spanish] El carcinoma diferenciado de tiroides (CDT) asociado a enfermedad de Graves (EG) es una asociación relativamente rara, ocurriendo en el 0,3 % al 9,8 % de los pacientes operados por EG. Se presenta el caso de un paciente con EG y CDT de tiroides con características evolutivas y terapéuticas peculiares. Varón de 22 años que consultó por obesidad. Peso: 116,4 kg, Talla: 1,73 m, BMI: 38,9, clínicamente eutiroideo, con palpación tiroidea dificultosa por grosor de cuello. Análisis iniciales: T3, T4 y TSH dentro de rango normal y ecografía tiroidea con nódulo hipoecoico en lóbulo derecho (LD) de 11 x 10 mm. Se le solicitó punción aspirativa con aguja fina (PAAF) bajo guía ecográfica. Vuelve a los 4 meses con cuadro clínico de hipertiroidismo. Análisis: T3: 557 ng/dL, T4: 18,8 mcg/dL, T4 L: 3,73 ng/dL, TSH: < 0,01 μIU/mL, ATPO: 186 UI/mL, ATG: 965 UI/mL. La citología mostró: {sup H}allazgos citológicos vinculables con carcinoma papilar (CP) tiroideo{sup .} Centellograma tiroideo: {sup N}ódulo integrado en LD{sup .} Es tratado con metimazol y se opera a los 2 meses: {sup T}iroidectomía total{sup ;} cuya anatomía patológica (AP) reveló un {sup C}P variante folicular en lóbulo derecho y zona de CP variante clásica en lóbulo izquierdo{sup .} A los 35 y 60 días de operado (sin instaurar levotiroxina): presenta TSH <0,1 μIU/mL con T3 y T4 normales

  5. Pneumomediastino espontâneo: Asma

    Directory of Open Access Journals (Sweden)

    Marcelo Cunha Fatureto

    2008-05-01

    Full Text Available Resumo: Pneumomediastino é definido como a presença de ar livre no mediastino, sendo que o espontâneo ocorre na ausência de enfermidades ou factores precipitantes. É raro em adultos, sendo mais frequente em recém-nascidos. Contudo, ocorre mais em adultos jovens, sendo 8:1 a relação entre homens e mulheres. Constitui achado raro na asma, representando 1% dos casos. Os sintomas mais frequentes são dor torácica e dispneia. O diagnóstico é feito com exames de imagem, como radiografia e tomografia computadorizada de tórax. O tratamento de escolha é conservador, não operatório, com prognóstico favorável na maioria dos casos. O nosso propósito é relatar um caso desta patologia em jovem atendido em nosso serviço com quadro de dor torácica e dispneia, sendo submetido a exames complementares e feito o diagnóstico de pneumomediastino espontâneo. O doente foi submetido a tratamento conservador com excelente evolução clínica. No momento encontrase assintomático, em acompanhamento ambulatorial.Rev Port Pneumol 2008; XIV (3: 437-441 Abstract: Pneumomediastinum is defined as the presence of free air in the mediastinum, and the spontaneous occurs in the absence of diseases or precipitating factors. It is rare in adults, and it is more frequent in new-borns. However, it occurs more in young adults, with an 8:1 relationship between men and women. It constitutes a rare finding in asthma, representing 1% of the cases. More frequent symptoms are chest pain and dyspnea. Diagnosis is made with image examinations, such as radiography and chest computed tomography. Treatment of choice is conservative, nonoperative, with a favourable prognosis in the majority of the cases. Our aim is to report a case of this pathology in a young adult seen in our service with chest pain and dyspnea. He underwent complementary examinations and the diagnosis was spontaneous pneumo-mediastinum. This patient

  6. Pesando riscos e benefícios: lições aprendidas com as intervenções terapêuticas de um caso com pré-eclâmpsia grave Balance entre beneficios y riesgos: lecciones aprendidas con las intervenciones terapéuticas de un caso con preclampsia grave Balancing the benefits and risks: lessons learned from the therapeutic interventions of a case with severe preeclampsia

    Directory of Open Access Journals (Sweden)

    Shiqin Xu

    2013-06-01

    érias.JUSTIFICATIVA Y OBJETIVOS: La preclampsia es un síndrome de la disfunción de múltiples órganos (SDMO debido a sus manifestaciones típicas y atípicas que incluyen hipertensión, proteinuria, síndrome HELLP, encefalopatía hipertensiva y coagulopatía. El manejo ideal de esos pacientes necesita una evaluación del balance entre los beneficios y riesgos de las estrategias terapéuticas, anestésicas y obstétricas. RELATO DE CASO: Paciente embarazada de 35 años, con un embarazo anterior sin complicaciones, llegó a nuestro instituto médico en carácter de urgencia a las 29 semanas de embarazo. La paciente estaba con mareos, molestias en el pecho, cardiopalmia, visión nublada y sangramiento vaginal. Posteriormente al examen físico y laboratorial, la paciente fue diagnosticada con preclampsia grave, síndrome HELLP, desplazamiento prematuro de la placenta y SDMO. La paciente también presentaba una deformidad de la columna vertebral y pélvica, fijación de la articulación mandibular y desplazamiento traqueal debido a un accidente de tránsito ocurrido hacía 11 años. Por tanto, se realizó una cesárea de urgencia con anestesia general con intubación nasotraqueal usando un cable guía. La paciente recibió alta directamente de la unidad de cuidados intensivos obstétrica (UCI-OB al séptimo día del postoperatorio, con una presión arterial normal y la recuperación completa de las funciones orgánicas. CONCLUSIONES: Este caso merece una discusión más detallada sobre las consideraciones anestésicas al momento de tomar una decisión clínica para el tratamiento de tal paciente. El bloqueo del neuro eje es la primera elección para pacientes con preclampsia sometidas a la cesárea cuando existe una trombocitopenia moderada, pero no progresiva. Cuando se opta por la anestesia general, una sedación y una analgesia adecuadas se hacen necesarias para el buen control de la respuesta del estrés a la intubación, especialmente en los pacientes con signos neurológicos, y

  7. Tratamiento de la enfermedad de Graves Basedow

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    Hernando Vargas-Uricoechea

    2014-05-01

    Full Text Available Se realizó una revisión narrativa rigurosa de la literatura inglesa y en español sobre diferentes aspectos de la Enfermedad de Graves-Basedow e hipertiroidismo. Esta patología –parte de la llamada “enfermedad tiroidea autoinmune”- se produce como consecuencia de la presencia de anticuerpos circulantes que se unen y activan al receptor de tirotropina, desencadenándose generalmente el hipertiroidismo en asociación con un estrés agudo. En este artículo actualizamos tanto el manejo de hipertiroidismo como el de problemas especiales con el que puede estar asociado. La fisiopatología y el diagnóstico de la Enfermedad de Graves-Basedow son motivo de otra publicación.

  8. Prevalência e gravidade de asma brônquica em adultos obesos com indicação de cirurgia bariátrica Prevalence and severity of asthma in obese adult candidates for bariatric surgery

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    Saulo Maia Davila Melo

    2011-06-01

    Full Text Available OBJETIVO: Determinar a prevalência de asma em um grupo de adultos obesos, candidatos a cirurgia bariátrica e avaliar a gravidade da asma neste grupo de pacientes. MÉTODOS: Estudo transversal, envolvendo 363 pacientes obesos adultos (índice de massa corpórea > 35 kg/m² avaliados por um médico pneumologista, utilizando a avaliação clínica como instrumento diagnóstico de asma. Todos os pacientes foram submetidos à avaliação clínica e espirometria e foram divididos em dois grupos (asma e controle. Os pacientes com asma foram classificados conforme a gravidade da doença. RESULTADOS: A prevalência de asma na população de obesos estudada foi de 18,5% (IC95%: 14,5-22,4. Essa prevalência nas mulheres e nos homens foi de 20,4% (IC95%: 16,2-24,5 e 13,7% (IC95%: 10,1-17,2, respectivamente. Havia sintomas de asma nos últimos doze meses em 8,0% (IC95%: 5,2-10,7, e houve manifestação inicial dos sintomas de asma na infância/adolescência em 17,4% (IC95%: 13,5-21,3. No grupo asma, asma intermitente estava presente em 29 pacientes (43,3%; asma persistente leve, em 7 (10,4%; asma moderada, em 25 (37,3%; e asma persistente grave, em 6 (9,0%. CONCLUSÕES: A prevalência de asma neste grupo de adultos obesos, utilizando-se a avaliação clínica como critério diagnóstico, mostrou-se elevada, com predomínio no sexo feminino e com manifestação inicial dos sintomas de asma na infância/adolescência. A gravidade da asma neste grupo de obesos adultos esteve entre os valores médios estimados para a população geral, com uma maior proporção de asma intermitente, asma persistente leve e asma persistente moderadaOBJECTIVE: To determine the prevalence of asthma in a group of obese adult candidates for bariatric surgery and to evaluate the severity of asthma in this group of patients. METHODS: This was a cross-sectional study involving 363 obese adults (body mass index > 35 kg/m² evaluated by a pulmonologist, using clinical evaluation as a

  9. Epigenetics in asthma Epigenética en asma

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    Luis Caraballo

    2009-11-01

    ="EN-US">genes, respectively.

    Smoking, bacterial and viral infections, maternal diet and environmental pollution are also factors that trigger epigenetic processes such as histone acetylation and induction of inflammatory cytokines, inactivation of histone deacetytransferases, polarization of the immune response toward the Th2 type and increased production of IgE and cytokines of this profile. We review the epigenetic effects resulting from therapy with corticosteroids and theophylline, and other factors that might influence the risk of asthma in childhood such as maternal intake of fruits, vegetables, fish oils, vitamins, minerals, and the use of probiotics and antibiotics during pregnancy.

    El asma es una enfermedad respiratoria crónica con alta heredabilidad. Se ha propuesto que en su patogénesis participan varios genes con efectos variables al igual que factores ambientales, y se ha sugerido que los mecanismos epigenéticos pueden mediar parte del efecto de los factores ambientales en el comienzo y la evolución de la enfermedad. La epigenética describe los cambios en la expresión génica heredables durante las mitosis y meiosis que no son codificados en la secuencia de ADN. Ellos incluyen la metilación o desmetilación del ADN y la acetilación, desacetilación, ubiquitinación, sumoilación y fosforilación de histonas, cambios en los microARN y alteraciones cromatínicas. En esta revisión se describen hallazgos que establecen una relación entre algunos mecanismos epigenéticos y el

  10. Efectividad de la acupuntura en la crisis aguda de asma bronquial

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    María Teresa Paz Rodríguez

    2014-10-01

    Full Text Available Introducción: el asma bronquial es una enfermedad respiratoria con significativa prevalencia y una de las principales causas de ingreso hospitalario y la acupuntura una forma terapéutica de la Medicina Tradicional y Natural con múltiples indicaciones, dentro de ellas esta afección. Objetivo: determinar la evolución de los pacientes asmáticos persistentes moderados de ambos sexos antes y después del tratamiento con acupuntura en el servicio de urgencia en el Hospital General Docente Abel Santamaría Cuadrado de Pinar del Río. Material y método: se realizó un estudio de intervención, prospectivo, longitudinal, utilizando la acupuntura como modalidad terapéutica de la Medicina Tradicional China en pacientes que acudieron al cuerpo de guardia de Medicina Interna del Hospital General Docente "Abel Santamaría Cuadrado" de Pinar del Rio, en el período comprendido entre octubre-diciembre del 2013. El universo lo integraron todos los pacientes que acudieron a la consulta con crisis aguda de asma bronquial (223 y la muestra, 83 pacientes clasificados como asmáticos persistentes moderados utilizándose acupuntura en los puntos pulmón 7, vaso concepción 17 y vejiga 13 al grupo de estudio (41 pacientes y 42 con tratamiento convencional. Resultados: al tratar estos pacientes se ha evidenciado que el 78,4% de ellos mejoró por la aplicación de este método milenario. Ninguno presentó complicaciones y sólo 11 pacientes no mejoraron. Conclusiones: los pacientes respondieron de igual forma al tratamiento sin distinción de edad y sexo, demostrando este método ser eficiente, de fácil aplicación con aparición de menos reacciones adversas y además, económico.

  11. Polimorfismos del gen pfmdr1 en muestras clínicas de Plasmodium falciparum y su relación con la respuesta terapéutica a antipalúdicos y paludismo grave en Colombia

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    Paula Montoya

    2007-06-01

    Conclusiones. Los polimorfismos 86Tir y 1246Tir en el gen pfmdr1 no son útiles como factores de predicción de falla terapéutica o paludismo grave en los municipios estudiados. Este estudio describe por primera vez la presencia del alelo 86Tir en cuatro muestras clínicas de Suramérica.

  12. Sintomas e fatores de risco para asma entre escolares piauienses Síntomas y factores de riesgo para el asma entre escolares piauienses Symptoms and risk factors for asthma among piauiense schoolchildren

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    Gessianne Carvalho Castro

    2012-01-01

    Full Text Available OBJETIVOS: Analisar a prevalência de sintomas de asma entre escolares de seis a sete anos do município de Picos-PI; e identificar fatores de risco associados à doença. MÉTODOS: Estudo transversal realizado com crianças de 6 e 7 anos de Picos em novembro de 2010 a maio de 2011. Para coletar os dados, foi utilizado um formulário adaptado do Internacional Study of Asthma and Allergies in Childhood. Os dados foram analisados com base na estatística descritiva e analítica. RESULTADOS: Dentre as 234 crianças da amostra estudada, 56% eram do gênero feminino. A prevalência de diagnóstico médico de asma foi de 7,7%. Os seguintes fatores de risco apresentaram relação estatisticamente significante com a ocorrência de asma (p OBJETIVOS: Analizar la prevalencia de síntomas de asma entre escolares de seis a siete años del municipio de Picos-PI; e identificar factores de riesgo asociados a la enfermedad. MÉTODOS: Estudio transversal realizado con niños de 6 y 7 años de Picos en noviembre de 2010 a mayo de 2011. Para recolectar los datos, se utilizo un formulario adaptado del Internacional Study of Asthma and Allergies in Childhood. Los datos fueron analizados con base en la estadística descriptiva y analítica. RESULTADOS: De los 234 niños de la muestra estudiada, el 56% era del género femenino. La prevalencia del diagnóstico médico de asma fue de 7,7%. Los siguientes factores de riesgo presentaron relación estadísticamente significativa con la ocurrencia de asma (p OBJECTIVES: To assess the prevalence of asthma symptoms among schoolchildren aged six to seven years in the municipality of Picos-PI; and to identify risk factors associated with the disease. METHODS: A cross-sectional study with children aged six and seven from Picos, in November 2010 and May 2011. To collect data, we used an adapted form of the International Study of Asthma and Allergies in Childhood. Data were analyzed using descriptive and analytical statistics

  13. Asma alérgica, niveles de IgE total y exposición a los acaros del polvo casero en el municipio de Santiago de Tolú, Colombia

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    Salomón Rodríguez Monterroza

    2013-10-01

    Full Text Available ResumenLa creciente prevalencia del asma a nivel mundial hace necesaria la investigación de factores que influyen sobre su etiologia y patogénesis. En Colombia la prevalencia de asma es tan alta como en los paises industrializados. Un estudio de historias dinicos en el municipio de Santiago de Tolú (Colombia, mostró un alto porcentaje de consulta por asma y rinitis alérgica en la población infantil. Con el objetivo de determinarla frecuencia de asma en la población general se realizó un estudio descriptivo de corte transversal, partiendo de la información recolectada con un cuestionario diseñado y probado. Se encuestaron 316 personas, con representatividad de grupos etéreos y estratos socioeconómicos. El diagnóstico fue confirmado mediante espirometria y medición de los niveles de ige total en sangre. Como resultado se encontró que 8,9% de la población mostró sintomas clinicos y espiromet ría positiva paro  asma con niveles de ige total > 100 Ul/ml, siendo los niños entre 5 y 15 años los más afectados (71.5%. La encuesta permitió evaluar la sensibilidad a factores ambientales, siendo el polvo casero y el humo del cigarrillo los más asociados a la enfermedad. La presencia de ácaros en el polvo acumulado en colchones be confirmada, siendo Dennatophagoides pteronyssinusy Momia tropicalis las especies más frecuen-tes. (Duazary 2006; 1: 10- 17 

  14. Højfolkets Grave

    DEFF Research Database (Denmark)

    2007-01-01

    For the special exhibition 'Højfolkets Grave - Oak Coffins from Borum Eshøj' on Moesgaard Museum in 2007: The development of 3D graphics which was displayed on a big screen in the exhibition. The animation shows - in a very stylistic way - the design principles behind the construction of Bronze Age...

  15. Management of Graves' ophthalmopathy

    NARCIS (Netherlands)

    Wiersinga, Wilmar M.

    2007-01-01

    Management of Graves' ophthalmopathy is preferably done in a multidisciplinary setting. Smoking is associated with worse disease outcome. (131)I therapy for hyperthyroidism can also worsen ophthalmopathy, especially if administered during active disease or to patients who smoke or have severe

  16. Los antihistamínicos H1 de primera generación en el tratamiento del asma bronquial ¿si o no?

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    Alicia Zapata Martínez

    1996-06-01

    Full Text Available Se hace una revisión sobre el uso de los antihistáminicos H1 de primera generación en el tratamiento del asma bronquial. Se concluye que sólo deben tenerse en cuenta para el trata miento de pacientes asmáticos con rinitis alérgica crónica cuando no estén en un ataque agudo de asma.A review on the use of first generation antihistamics H1 in the treatment of bronchial asthma is carried out. It is concluded that they should only be taken into account for treating asthmatic patients with chronic allergic rhinitis when they are not under an acute asthma attack.

  17. Efektifitas Dukungan Sosial Dokter kepada Orangtua dalam Tata Laksana Anak Asma

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    Fx. Wikan Indrarto

    2016-11-01

    Kesimpulan. Pemberian dukungan sosial dokter tidak berhubungan dengan keberhasilan tata laksana anak asma. Kepuasan orangtua akan pemberian dukungan sosial dokter, terutama diperoleh dari jenis dukungan penghargaan.

  18. Tratamiento del asma bronquial en niños según la medicina Bioenergética y Natural

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    Sandra Haydée Hernández García

    2015-04-01

    Full Text Available Introducción: el asma bronquial es «la inflamación crónica de la vía aérea en la que desempeñan un papel destacado algunas células y mediadores. Es la enfermedad crónica en niños más frecuente a nivel mundial. Los tratamientos ofrecidos por la medicina alopática, si bien ofrecen control de síntomas con buenos resultados, no son efectivos en la totalidad de los pacientes. Las diferentes técnicas de la medicina Bioenergética y Natural son alternativas valiosas para el tratamiento del asma, ya que ofrecen la posibilidad de erradicar los síntomas de forma definitiva. Objetivo: diseñar una base teórico-metodológica para el desarrollo de la medicina bioenergética y natural como elemento que contribuya a elevar la calidad de la atención médica pediátrica. Material y método: se realizaron búsquedas en bases de datos bibliográficas computarizadas de estudios publicados en revistas indexadas como: Medline, Bireme, Lilacs, Índice Médico Español, Cochrane Library, Alternative Medicine Electronic Database, Acubase, BioMed Central. Se buscaron estudios, con los siguientes términos: asthma, acupuncture, therapy acupuncture gender, phisical therapy acupuncture, pediatric patients, pediatric asthma, children, homeopatic adolescent, acupressure. Resultados: se ofrecen opciones terapéuticas a la luz de la medicina Bioenergética y Natural aplicables a la edad pediátrica, útiles en el manejo del asma bronquial en niños en consultas ambulatorias u hospitalizados a la vez, teniendo en cuenta y aprovechando los conocimientos y los avances científicos de la alopatía. Conclusiones: esta revisión es una guía para los médicos que atienden niños, tanto en atención primaria como secundaria. La aplicación de estas terapias redundará en su salud, contribuirá además al tratamiento más efectivo del asma bronquial, es necesario elevar la calidad de las investigaciones es este campo para contribuir a la validación de la eficacia de

  19. Tendência temporal de asma em crianças e adolescentes no Brasil no período de 1998 a 2008 Tendencia temporal de asma en niños y adolescentes en Brasil en el período de 1998 a 2008 Time trend of asthma in children and adolescents in Brazil, 1998-2008

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    Fernando César Wehrmeister

    2012-04-01

    Full Text Available OBJETIVO: Analisar as tendências de asma em crianças e adolescentes entre 1998 e 2008 no Brasil. MÉTODOS: Foram analisados os dados de prevalência de asma da Pesquisa Nacional por Amostra de Domicílios, dos anos de 1998, 2003 e 2008. A amostra foi constituída por 141.402, 144.443 e 134.032 indivíduos em 1998, 2003 e 2008, respectivamente, e a análise foi ajustada pelo desenho amostral. As tendências de asma foram descritas por sexo, regiões do Brasil e local de residência, em crianças (zero a nove anos e adolescentes (dez a 19 anos. RESULTADOS: A prevalência de asma entre crianças foi 7,7% em 1998, 8,1% em 2003 e 8,5% em 2008, com um incremento anual de 1%. O maior aumento anual foi observado nas regiões Sudeste e Norte (1,4%. Entre o grupo de adolescentes, a prevalência de asma foi de 4,4% em 1998, 5,0% em 2003 e 5,5% em 2008, com aumento de 2,2% ao ano. Na região Nordeste, o aumento anual na prevalência de asma foi de 3,5%. Os maiores incrementos foram observados entre os meninos e entre moradores da zona rural. CONCLUSÕES: Apesar de a asma apresentar um decréscimo em países emergentes, no Brasil os resultados apontam um incremento da asma entre crianças e adolescentes no período de 1998 e 2008, especialmente na zona rural.OBJETIVO: Analizar las tendencias de asma en niños y adolescentes entre 1998 y 2008 en Brasil. MÉTODOS: Se analizaron los datos de prevalencia de asma de la Investigación Nacional por Muestra de Domicilios, de los años de 1998, 2003 y 2008. La muestra fue constituida por 141.402, 144.443 y 134.032 individuos en 1998, 2003 y 2008, respectivamente y el análisis fue ajustado por el diseño muestral. Las tendencias de asma fueron descritas por sexo, regiones de Brasil y lugar de residencia, en niños (cero a nueve años y adolescentes (diez a 19 años. RESULTADOS: La prevalencia de asma entre niños fue de 7,7% en 1998, 8,1% en 2003 y 8,5% en 2008, con un incremento anual de 1%. El mayor aumento anual

  20. Xantinas en el asma: ¿ascenso o descenso?

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    Rogelio Alvarez Sintes

    Full Text Available La teofilina ha sido utilizada como broncodilatador en el tratamiento del asma en su forma aguda y crónica desde hace más de 50 años. A partir de 1990 el uso de las xantinas en el asma se discute cada vez más. En 1995 persisten las controversias, pero la balanza se desplaza cada vez más hacia los broncodilatadores simpaticomiméticos, pasando a ocupar ésta la tercera o cuarta opción en los esquemas terapéuticos.1-4 Se revisa la literatura médica al respecto y se exponen las razones para su mayor o menor uso.

  1. Xantinas en el asma: ¿ascenso o descenso?

    Directory of Open Access Journals (Sweden)

    Rogelio Alvarez Sintes

    1995-08-01

    Full Text Available La teofilina ha sido utilizada como broncodilatador en el tratamiento del asma en su forma aguda y crónica desde hace más de 50 años. A partir de 1990 el uso de las xantinas en el asma se discute cada vez más. En 1995 persisten las controversias, pero la balanza se desplaza cada vez más hacia los broncodilatadores simpaticomiméticos, pasando a ocupar ésta la tercera o cuarta opción en los esquemas terapéuticos.1-4 Se revisa la literatura médica al respecto y se exponen las razones para su mayor o menor uso.

  2. Efecto de la terapia UVB de banda estrecha sobre la síntesis de vitamina D y los parámetros de síndrome metabólico en pacientes con psoriasis moderada y grave

    OpenAIRE

    Romaní de Gabriel, Jorge

    2013-01-01

    La psoriasis es una enfermedad cutánea crónica que ha sido relacionada con el síndrome metabólico. El objetivo de este trabajo fue evaluar en pacientes con psoriasis la presencia de alteraciones en parámetros antropométricos y marcadores séricos relacionados con el síndrome metabólico, y su modificación tras un tratamiento con ultravioleta B de banda estrecha. Comparamos a 50 pacientes con psoriasis con 50 controles emparejados por sus características antropométricas (edad, sexo e índice de m...

  3. Microchimerism in Graves' Disease

    Science.gov (United States)

    Galofré, Juan C.

    2012-01-01

    Microchimerism is the presence of cells from one individual in another genetically distinct individual. Pregnancy is the main cause of natural microchimerism through transplacental bidirectional cell trafficking between mother and fetus. The consequences of pregnancy-related microchimerism are under active investigation. However, many authors have suggested a close relationship linking fetal microchimerism and the development of autoimmune diseases. It has been more than ten years now since the demonstration of the presence of a significant high number of fetal microchimeric cells residing in thyroid glands from operated patients with Graves' disease. This intrathyroidal fetal microchimerism is an attractive candidate mechanism for the modulation of Graves' disease in pregnancy and the postpartum period. PMID:22577597

  4. [Grave's disease in 2009].

    Science.gov (United States)

    Philippe, Jacques

    2009-04-08

    Grave's disease is an autoimmune disease of the thyroid gland characterized by hyperthyroidism, a homogenous goiter and occasionally an ophtalmopathy. It occurs in less than 1% of the population with a large predominance in women (10/1). Treatment is directed to inhibit thyroid hormone synthesis with carbimazole during 12-18 months. Recurrence rates after stopping treatment is about 50%; in these patients, radioactive iodine is the preferred treatment.

  5. Controlo clínico e histopatológico da asma quando utilizada a hiperreactividade brônquica como um indicador adicional no tratamento da asma a longo prazo

    Directory of Open Access Journals (Sweden)

    Jacob K. Sont

    2000-01-01

    elaboração de Consensos Intenacionais (4 para o Diagnóstico e Tratamento desta doença. Desde 1992, têm sido feitas várias actualizações eo que se propõe neste trabalho, é a importância de inclusão do estudo da hiperreactividadc brônquica como critério adicional de detemrminayação da gravidade da asma e consequentemente, da terapeutica. Deste modo é obtido um melhor controlo clinico e functional, bem como a redução das alterações inflamatórias observadas em estudos biópticos (3,6.Entre nós (1, numa fase inicial do diagnóstico de asma, considerase que a avaltação funcional deve ser sempre que possível completa, sendo realizados o estudo da mecânica venlilatória com estudo farmacodinâmico (prova da provocação inalatória inespecifica ou de broncodilatação se o doente estiver obstruido.Uma vez feito o diagnóstico e para monitorização da asma, é habitualmente feita espirometria. Nas situações mais graves e sempre que haja centros equipados, a repetição das Provas Funcionais Respiratórias sera realizada posteriormente, de modo a avaliar a evolução funcional em termos de grau de obstrução brônquica, insulação pulmonar e hiperreactividade brônquica.No domicílio a monitorização é feita através da determinação diária do DEMI (4 Para alguns autores, estas determinaçõs devem ser realizadas particularmente numa fase inicial, nos doentes com asma grave ou naqueles que menosprezam a sua sintomatologta (2.Como é referido no presente trabalho, certamente que o estudo da hiperreactividade brônquica tem interesse quer em termos de diagnóstico, quer prognóstico (5,7 e mesmo para monitorização da resposta à terapêutica. A sua inclusão como critério de gravidade nurn Consenso Internacional é contudo um pouco mais complexa, pela dispartdade de meios técnicos e humanos

  6. Adesão ao tratamento de manutenção em asma (estudo ADERE Compliance with maintenance treatment of asthma (ADERE study

    Directory of Open Access Journals (Sweden)

    José Miguel Chatkin

    2006-08-01

    Full Text Available OBJETIVO: Avaliar a adesão ao tratamento preventivo de asma persistente moderada e grave. MÉTODOS: Médicos de vários Estados do país foram contactados para selecionar asmáticos persistentes moderados ou graves, maiores de doze anos. Os pacientes receberam salmeterol/fluticasona 50/250 µg diskus durante 90 dias (sendo orientados a retornarem as embalagens ao final do estudo para conferência da dosagem total utilizada. Receberam telefonemas da equipe do estudo no início e ao final de 90 dias para que fosse avaliada a adesão. Foi considerado como aderente ao tratamento o asmático que utilizou no mínimo 85% das doses prescritas. As variáveis estudadas foram sexo, idade, cor, estado civil, escolaridade, tabagismo atual, outras atopias, co-morbidades, gravidade da asma, uso de outras medicações e número de hospitalizações por asma. RESULTADOS: Foram incluídos 131 pacientes oriundos de quinze estados, com taxa geral de adesão de 51,9%. Houve diferença significativa na adesão quanto à gravidade da asma (maior adesão nos casos graves; p = 0,02. Não houve diferença estatisticamente significativa nas demais variáveis. CONCLUSÃO: A taxa geral de adesão ao tratamento de manutenção da asma foi baixa.OBJECTIVE: To determine the rate of compliance with preventive treatment of moderate and severe persistent asthma. METHODS: Physicians at various medical centers across the country were invited to nominate patients for participation in the study. Inclusion criteria were being over the age of 12 and presenting moderate or severe persistent asthma. Participating patients received salmeterol/fluticasone 50/250 µg by dry powder inhaler for 90 days and were instructed to return the empty packages at the end of the study as a means of determining the total quantity used. In order to evaluate compliance, a member of the research team contacted each patient via telephone at the study outset and again at the end of the 90-day study period

  7. Concepciones de la medicina oriental sobre el asma bronquial Concepts of the eastern medicine on the bronchial asthma

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    Ileana Cutiño Clavel

    Full Text Available Con el objetivo analizar los principios sobre los cuales se sustenta la medicina oriental para verificar la presencia del asma, se revisaron documentos específicos sobre la materia, donde se incluía la valoración acerca de si las alteraciones energéticas referidas fundamentan la existencia de manifestaciones respiratorias del asma bronquial, según las concepciones de la medicina occidental. Se encontraron puntos de contacto entre los criterios orientales y occidentales en cada una de las desarmonías energéticas.With the objective of analyzing the principles on which the eastern medicine is sustained to verify the presence of asthma, specific documents on the subject were reviewed, where the evaluation about whether the referred energy alterations support the existence of breathing manifestations of the bronchial asthma was included, according to the concepts of the western medicine. Contact points among the eastern and western approaches in each of the energetic disharmonies were found.

  8. Tratamiento de la enfermedad de Graves Basedow

    OpenAIRE

    Hernando Vargas-Uricoechea; Carlos Hernán Sierra-Torres; Ivonne Alejandra Meza-Cabrera

    2014-01-01

    Se realizó una revisión narrativa rigurosa de la literatura inglesa y en español sobre diferentes aspectos de la Enfermedad de Graves-Basedow e hipertiroidismo. Esta patología –parte de la llamada “enfermedad tiroidea autoinmune”- se produce como consecuencia de la presencia de anticuerpos circulantes que se unen y activan al receptor de tirotropina, desencadenándose generalmente el hipertiroidismo en asociación con un estrés agudo. En este artículo actualizamos tanto el manejo de hipertiroid...

  9. Broncoespasmo induzido pelo exercício em crianças e adolescentes com diagnóstico de asma

    OpenAIRE

    Cassol,Vitor E.; Trevisan,Maria E.; Moraes,Eliane Z. C. de; Portela,Luiz O. C.; Barreto,Sérgio Saldanha Menna

    2004-01-01

    INTRODUÇÃO: A broncoconstrição temporária após o exercício físico tem elevada prevalência em crianças e adolescentes asmáticos. OBJETIVO: Determinar a freqüência e gravidade do broncoespasmo induzido pelo exercício em crianças e adolescentes, com diagnóstico clínico de asma leve, moderada e grave. MÉTODO: Foi realizado um estudo descritivo, tipo transversal, não controlado. A amostra constituiu-se de 40 indivíduos asmáticos, de ambos os sexos, com idade entre 7 e 18 anos, que não utilizavam r...

  10. Initial Evaluation of (99m)Tc(CO)3(ASMA) as a Renal Tracer in Healthy Human Volunteers.

    Science.gov (United States)

    Lipowska, Malgorzata; Klenc, Jeffrey; Folks, Russell D; Taylor, Andrew T

    2014-09-01

    Preclinical studies in rats showed that two of (99m)Tc(CO)3(ASMA) isomers (rac- and L-ASMA) had pharmacokinetic properties equivalent to that of (131)I-OIH, the radiopharmaceutical standard for the measurement of effective renal plasma flow. The aim of this study was to evaluate the pharmacokinetics of (99m)Tc(CO)3(ASMA) isomers in healthy human subjects. Three ASMA ligands (rac-, L- and D-ASMA) were labeled with (99m)Tc(CO)3 using an IsoLink kit (Covidien), and each formed (99m)Tc(CO)3(ASMA) tracer was co-injected with (131)I-OIH into healthy human subjects followed by sequential imaging, plasma clearance measurements and timed urine collection. Plasma protein binding, red cell uptake and percent injected dose in the urine were determined. Urine from each group of volunteers was analyzed for metabolites by HPLC. Image quality was excellent with all three agents. Each (99m)Tc(CO)3(ASMA) preparation was excreted unchanged in the urine. The plasma clearance ratio ((99m)Tc(CO)3(ASMA)/(131)I-OIH) was 81 ± 3 % for D-ASMA compared to only 20 ± 4 % for L-ASMA and 37 ± 7 % for rac-ASMA; the 81 % clearance ratio for D-ASMA isomer is still ∼ 30 % higher than the (99m)Tc-MAG3/(131)I-OIH clearance ratio (∼50-60 %). Red cell uptake was similar for all three tracers (6-9 %), and all tracers had a relatively rapid renal excretion; at 3 h, the (99m)Tc(CO)3(ASMA)/(131)I-OIH urine ratio was 100 ± 3 % for D-ASMA, 80 ± 2 % for L-ASMA and 88 ± 1 % for rac-ASMA. The renal excretion characteristics of (99m)Tc(CO)3(D-ASMA) in humans are superior to those of the other two (99m)Tc(CO)3(ASMA) isomers studied, but are still inferior to (131)I-OIH, even though there was no difference in the clearance of two of (99m)Tc(CO)3(ASMA) isomers and (131)I-OIH in rats. The work described here demonstrates the sensitivity in in vivo biological behavior of (99m)Tc(CO)3(ASMA) isomers to their subtle structural differences.

  11. Prevalencia y factores asociados al asma en niños de 5 a 14 años de un área rural del sur del Perú

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    César V. Munayco

    2009-07-01

    Full Text Available Objetivos. Determinar la prevalencia y los factores asociados al asma en niños de 5 a 14 años de una zona rural en la provincia de Ica, Perú. Materiales y métodos. Se realizó un estudio transversal en niños de 5 a 14 años del distrito de Santiago, Ica, en el año 2004. Se visitaron a las madres de los niños seleccionados a través de un muestreo aleatorio sistemático y se aplicó un cuestionario basado en el ISAAC, asimismo, se evaluaron factores asociados al asma. Tomando el desarrollo de asma como variable de respuesta, se efectuó un modelo de regresión logística binaria a fin de identificar los factores que se le asocian de manera independiente. Resultados. De un total de 200 sujetos, 186 fueron encuestados, 25 de ellos cumplían la definición de asma, la prevalencia global de asma fue de 13,5% (IC95%: 8,8 - 19,8%, predominando ligeramente en los niños menores de 5 años (39% respecto al resto de grupos de edad (16 y 7% para 6 a 10 y 11 a 14 años respectivamente. Dentro de los factores asociados a tener asma se encontraron el antecedente de padecer rinitis, haber recibido antibióticos durante el primer año de vida y tabaquismo del padre en el primer año de vida. Los factores protectores fueron haber tenido diarrea durante el primer año de vida y haber sido vacunados con BCG. Conclusiones. La prevalencia de asma en una zona rural es comparable con la de otras ciudades en el mundo. Se le asocian factores que pueden ser modificados como el tratamiento antibiótico durante el primer año de vida y el tabaquismo paterno.

  12. Asma bronquial en la población infantil de 5 a 14 años de un área de salud de Santiago de Cuba Bronchial asthma in children 5 to14 years from a health area of Santiago de Cuba

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    Nelsa Sagaró del Campo

    2013-04-01

    Full Text Available Se realizó un estudio observacional de 158 niños con asma bronquial -- seleccionados mediante un muestreo por conglomerado bietápico --, dispensarizados por dicha afección en el área de salud del Policlínico Docente "José Martí Pérez" de Santiago de Cuba, durante el 2011, a fin de estimar la prevalencia de las principales características clinicoepidemiológicas en ellos. En la investigación se obtuvo homogeneidad del sexo femenino en todos los grupos etarios, a pesar de un ligero predominio de los varones de 10 a 14 años de edad, así como primacía de la afección entre los precedentes patológicos personales y la conjuntivitis alérgica como antecedente familiar. Igualmente, el asma persistente grave tuvo un mayor porcentaje y los agentes desencadenantes de las crisis asmáticas fueron, en orden descendente de frecuencia, los alergenos domiciliarios, el humo del cigarro, las infecciones, los ejercicios, los contaminantes de tipo doméstico y los medicamentos. El tratamiento más empleado se basó en broncodilatadores y el menos habitual, en cromonas; en tanto el hacinamiento fue el factor desfavorable más observado en los hogares de estos niños y el control de la enfermedad resultó generalmente parcial.An observational study was carried in 158 children with bronchial asthma -- selected by a two-stage cluster sampling -- attended and monitored by this disease in the health area from "José Martí Pérez" Teaching Polyclinic of Santiago de Cuba during 2011, in order to estimate the prevalence of the main clinical and epidemiological characteristics in them. In the study homogeneity of the female sex was observed in all age groups, in spite of a slight predominance of males 10 to 14 years, as well as primacy of the disease between past medical history and allergic conjunctivitis as family history. Likewise, severe persistent asthma had a higher percentage and triggers of asthma attacks were, in decreasing order of frequency

  13. Sintomas e fatores de risco para asma entre escolares piauienses

    OpenAIRE

    Castro, Gessianne Carvalho; Sousa, Lívia Kênia de Carvalho; Vera, Paula Valentina de Sousa; Lima, Luisa Helena de Oliveira; Oliveira, Edina Araújo Rodrigues; Lima, Rúbia Fernanda Santos; Magalhães, Luis Fernando Beserra; Araújo, Nileide Lima; Lopes, Marcos Venícios de Oliveira

    2012-01-01

    OBJETIVOS: Analisar a prevalência de sintomas de asma entre escolares de seis a sete anos do município de Picos-PI; e identificar fatores de risco associados à doença. MÉTODOS: Estudo transversal realizado com crianças de 6 e 7 anos de Picos em novembro de 2010 a maio de 2011. Para coletar os dados, foi utilizado um formulário adaptado do Internacional Study of Asthma and Allergies in Childhood. Os dados foram analisados com base na estatística descritiva e analítica. RESULTADOS: Dentre as 23...

  14. Comportamiento del asma bronquial en la edad pediátrica

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    Lilian Jiménez Fontao

    2001-02-01

    Full Text Available Se realizó un estudio observacional, analítico, con un modelo de diseño del tipo casos y controles en la población de niños que acuden al Círculo Infantil "Sueños del Ché", con el fin de determinar la posible influencia de algunos factores de riesgo para padecer de asma bronquial. La investigación se realizó durante el curso escolar 1996-1997. El material de estudio quedó conformado por 166 niños, 21 de los cuales eran asmáticos (GE, el resto (145 eran los supuestamente sanos y conformaron el grupo control (GC. Como instrumento epidemiológico se utilizó el riesgo relativo (RR y su intervalo de confianza al 95 %, así como la prueba de Chi cuadrado. El sexo masculino predominó entre los enfermos y las manifestaciones alérgicas fueron más frecuentes entre los niños enfermos, así como en aquellos cuyos familiares era fumadores o que padecían de asma bronquial. El ketotifeno consiguió el 50 % de mejoría entre los enfermos, y la presencia de vectores y/o animales en el hogar no resultó un factor importante a considerarAn observational analytic case-control study was conducted in the population of children attending the "Sueños del Ché" Day Care Center in order to determine the possible influence of some risk factors on bronchial asthma. The investigation was made during the academic course 1996-1997. 166 children, 21 of whom were asthmatics (SG, and other 145 apparently sound (CG took part in the study. The relative risk and its confidence interval of 95 %, as well as the Chi square test were used as an epidemiological tool. Males prevailed among the sick and the allergic manifestations were more common in ill children and in those whose relatives were smokers or suffered from bronchial asthma. An improvement of 50 % was attained with the admnistration of ketotifen. The presence of vectors and/or animals at home was not an important factor to be considered

  15. Caracterización del asma bronquial en un área de salud

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    María Eulalia Prieto Herrera

    2000-08-01

    Full Text Available Se realizó un estudio descriptivo, transversal para caracterizar el asma bronquial en 2 grupos básicos de trabajo del Policlínico Comunitario Este, del municipio Camagüey durante el año 1996. El universo estuvo constituido por 260 pacientes dispensarizados como asmáticos, y mediante diseño muestral se tomaron 99 pacientes de 6 consultorios. La encuesta recogió variables como: grado de severidad, antecedentes familiares y personales de enfermedad atópica, momento en que aparecen las crisis y factores ambientales. El 54,5 % de los asmáticos eran ligeros; 68,6 % de los pacientes reconoció padecer de enfermedades atópicas. Existió un alto porcentaje de factores ambientales (95,9 % de polvo, 78,7 % de animales domésticos, 74,7 % de humedad. Se concluyó que la mayoría de los pacientes tenían familiares con enfermedades atópicas, más de la mitad de los pacientes presentaban crisis de asma bronquial con los cambios de temperatura. El polvo hogareño fue el factor ambiental más importante en la investigaciónA descriptive cross-sectional study was conducted to characterize bronchial asthma in 2 basic working groups of the Eastern Community Polyclinic, in the municipality of Camagüey, during 1996. 260 patients classified as asthmatic participated in the study. 99 patients were selected from 6 physician's offices as a sample.Variables such as severity degree, family and personal history of atopic disease, moment in which the crisis appears and environmental factors were collected in the survey. 54.5% of the asthmatic patients were mild, whereas 68.6% recognized having atopic diseases. There was a high percentage of environmental factors (95.9% of dust, 78.7% of pets, 74.7% of humidity. It was concluded that most of the patients had relatives with atopic diseases and that more than 50% of the patients had crises of bronchial asthma caused by the temperature changes. Home dust was the most important environmental factor found in the

  16. Prevention of Graves' ophthalmopathy.

    Science.gov (United States)

    Bartalena, Luigi

    2012-06-01

    Smoking is the most important risk factor for the occurrence/progression of Graves' ophthalmopathy (GO), as well as for its lower/slower response to immunosuppression. Accordingly, refrain from smoking should be urged, both as primary prevention (removal of risk factors in Graves' patients without GO), secondary prevention (early detection and treatment of asymptomatic/very mild GO) and tertiary prevention (reduction of complications/disability of overt GO). A 6-month course of 200 μg/day sodium selenite can prevent progression of mild GO to more severe GO and is, therefore, a form of secondary prevention and, probably, primary prevention. Correction of thyroid dysfunction and stable maintenance of euthyroidism are important preventive measures. The optimal treatment for hyperthyroidism in patients with GO is uncertain, because evidence demonstrating the superiority of antithyroid drugs over thyroid ablation (radioiodine, thyroidectomy, or both) is lacking. If radioiodine is used, low-dose steroid prophylaxis is recommended, particularly in smokers, to prevent radioiodine-associated GO progression. Copyright © 2011 Elsevier Ltd. All rights reserved.

  17. Estudo nacional de qualidade de vida na asma – Aplicação do Asthma Quality of Life Questionnaire de Marks (AQLQ-M na população portuguesa

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    Jorge Ferreira

    2008-07-01

    Full Text Available Resumo: A versão portuguesa do Asthma Quality of Life Questionnaire de Marks (AQLQ-M demonstrou anteriormente que apresenta boas propriedades psicométricas e é adequada para utilização em doentes portugueses com asma. Ao longo dos últimos 40 anos, tem vindo a observar-se um aumento global na prevalência, morbilidade, mortalidade e custos económicos associados à asma, continuando esta a ser uma doença subdiagnosticada e subtratada. Neste estudo, o AQLQ-M foi aplicado a 826 doentes asmáticos de Portugal continental (97,9% caucasianos; média de idades=40,5 anos; 30,2% do sexo masculino; 69,8% do sexo feminino seguidos em consulta de pneumologia ou imunoalergologia. Os doentes foram classificados de acordo com os níveis de gravidade do Global Initiative for Asthma (GINA. Apresentavam asma intermitente 40,5%; 26,9% asma persistente ligeira; 21,4% asma persistente moderada e 11,2% asma persistente grave. A pontuação do AQLQ-M manteve correlações estatisticamente significativas com a gravidade da asma, sintomas e função pulmonar. A maioria dos doentes não se apresentava controlada, tendo 74,6% recorrido ao serviço de urgência ao longo do último ano. Para todas as subescalas do questionário, as mulheres apresentavam pior qualidade de vida (QdV do que os homens. Surpreendentemente, os fumadores apresentavam melhor QdV do que os indivíduos que nunca fumaram. Os resultados deste estudo revelaram que a versão portuguesa do AQLQ-M é um instrumento útil para a medição da QdV relacionada com a saúde em adultos com asma.Rev Port Pneumol 2008; XIV (4: 459-486 Abstract: The Portuguese version of the Marks Asthma Quality of Life Questionnaire (AQLQ-M has already proven to have good diagnostic properties, and is suitable for use with Portuguese asthma patients. The last forty years have seen a worldwide rise in the rate, morbidity, mortality and economic burden associated

  18. Controvérsias no manejo farmacológico da asma aguda infantil Controversies in the pharmacological management of acute asthma in children

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    Sérgio Luís Amantéa

    2002-12-01

    Full Text Available Objetivos: apresentar uma revisão acerca de questões controversas, relativas ao manejo farmacológico utilizado nos pacientes pediátricos portadores de asma aguda. Fontes dos dados: foram utilizadas informações de artigos publicados em revistas científicas nacionais e internacionais, selecionadas das bases de dados Lilacs e Medline. Síntese dos dados: o artigo foi estruturado em tópicos, apresentando aspectos consensuais no tratamento farmacológico da asma infantil. Questões relacionadas à utilização de inaladores dosimetrados versus nebulizadores, o papel das drogas ß2-adrenérgicas utilizadas pela via endovenosa, bem como das metilxantinas e do sulfato de magnésio, são abordados de maneira crítica. Conclusões: os ß2-agonistas administrados pela via inalatória, associados aos coricosteróides, permanecem o tratamento de eleição para episódios agudos de asma na população pediátrica. Tanto os nebulizadores quanto os inaladores dosimetrados, acoplados a espaçadores, são efetivos para alívio dos sintomas agudos. Pacientes refratários ao tratamento convencional, que evoluem para quadros de asma aguda grave, devem ter considerada a utilização de drogas ß2-agonistas pela via endovenosa, desde que adequadamente monitorizados. Quanto às metilxantinas e ao sulfato de magnésio, devem ser considerados alternativas secundárias para pacientes selecionados.Objective: to present a review of controversial issues related to the pharmacological management of the treatment of acute asthma in children. Sources: articles published in national and international scientific journals. Data were selected from Lilacs and Medline databases. Summary of the findings: the article was organized into topics, presenting aspects on which there is consensus regarding the pharmacological treatment of asthma in children. Issues related to the use of metered dose inhaler versus nebulizers, the role of ß2-adrenergic drugs administered intravenously

  19. Current Concepts in Graves' Disease

    Science.gov (United States)

    Girgis, Christian M.; Champion, Bernard L.; Wall, Jack R.

    2011-01-01

    Graves' disease is the most common cause of hyperthyroidism in the developed world. It is caused by an immune defect in genetically susceptible individuals in whom the production of unique antibodies results in thyroid hormone excess and glandular hyperplasia. When unrecognized, Graves' disease impacts negatively on quality of life and poses serious risks of psychosis, tachyarrhythmia and cardiac failure. Beyond the thyroid, Graves' disease has diverse soft-tissue effects that reflect its systemic autoimmune nature. Thyroid eye disease is the most common of these manifestations and is important to recognise given its risk to vision and potential to deteriorate in response to radioactive iodine ablation. In this review we discuss the investigation and management of Graves' disease, the recent controversy regarding the hepatotoxicity of propylthiouracil and the emergence of novel small-molecule thyroid-stimulating hormone (TSH) receptor ligands as potential targets in the treatment of Graves' disease. PMID:23148179

  20. Graves' disease following subacute thyroiditis.

    Science.gov (United States)

    Nakano, Yoshishige; Kurihara, Hideo; Sasaki, Jun

    2011-12-01

    Subacute thyroiditis is a painful, inflammatory disease frequently accompanied with fever. It is suspected to be a viral infectious disease, while Graves' disease is an autoimmune disease. Thus, there appears to be no etiological relationship between the two diseases. A total of 25,267 thyroid disease patients made their first visits to our thyroid clinic during a period of 24 years between 1985 and 2008. Among them, subacute thyroiditis and Graves' disease accounted for 918 patients (3.6%) and 4,617 patients (18.2%), respectively. We have encountered 7 patients (one male and six female) with subacute thyroiditis followed by Graves' disease in this period (0.15% of the 4,617 patients with Graves' disease and 0.76% of the 918 patients with subacute thyroiditis). The age ranges were 40~66 years (mean 48.7 years) at the onset of subacute thyroiditis. The intervals between the onsets of subacute thyroiditis and Graves' disease were 1~8 months (mean 4.7 months). Because Graves' disease was preceded by subacute thyroiditis, the signs and symptoms of both diseases were evident together in the intervening period. The diagnosis of Graves' disease in those patients is always difficult because of atypical signs and symptoms and an unclear onset time. The causes of the Graves'disease that followed subacute thyroiditis are still unknown. However, the inflammatory nature of subacute thyroiditis may lead to the activation of the autoimmune response in susceptible subjects, resulting in the onset of Graves' disease. Graves' disease should be suspected when a high blood level of thyroid hormone persists after subacute thyroiditis.

  1. Qualidade de vida em doentes com asma Quality of life in asthma patients

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    Lara Noronha Ferreira

    2010-01-01

    Full Text Available Neste artigo é descrito um estudo, cujo objectivo é a medição da qualidade de vida relacionada com a saúde (QdVRS de doentes com asma e a apresentação de uma primeira aproximação aos valores normativos, com base no SF-6D, para aquele tipo de doentes. Pretende-se ainda averiguar a capacidade de medidas genéricas de medição da QdVRS distinguirem grupos em termos de características sociodemográficas. Aplicaram-se, por entrevista pessoal, as versões portuguesas do EQ-5D, do SF-6D, do AQLQ(S e do ACQ a uma amostra representativa da população portuguesa com asma. A maioria dos indivíduos não apresentou problemas significativos nas dimensões medidas, excepto na função física, onde os indivíduos reportaram limitações moderadas. Em média, os inquiridos apresentam valores de utilidade de 0,86. Os homens, os mais jovens, os solteiros, os indivíduos com habilitações literárias mais elevadas, os empregados, os indivíduos com rendimentos mais elevados e aqueles que residiam em zonas urbanas foram os que reportaram níveis de utilidade mais elevados. Por outro lado, os indivíduos que se encontravam num estádio mais avançado da doença reportaram, como era de esperar, níveis médios de utilidade inferiores aos dos que se encontravam num estádio menos grave da doença. Foram obtidos valores normativos para o SF-6D para doentes com asma por género, grupo etário, estado civil, habilitações literárias, situação profissional, local de residência e rendimento médio mensal líquido. As medidas de utilidade baseadas em preferências utilizadas neste estudo discriminam adequadamente grupos de doentes com asma, de acordo com grupos sociodemográficos. Os valores normativos obtidos podem ser usados em estudos de avaliação económica e estudos clínicos, uma vez que incorporam as preferências dos doentes e traduzem a utilidade atribuída ao seu estado de saúde.In this paper we present a study whose main aim is the

  2. Comportamiento del asma bronquial en Cuba e importancia de la prevención de las enfermedades alérgicas en infantes Behavior of bronchial asthma in Cuba and importance of the prevention from allergic diseases in infants

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    Anselmo Abdo Rodríguez

    2006-02-01

    Full Text Available El asma es una enfermedad frecuente que continúa siendo difícil de diagnosticar, sobre todo en la primera infancia; y además, es de difícil tratamiento, a pesar de los avances medicamentosos de los últimos años. Por tales razones, las organizaciones de salud pública y los organismos que se ocupan de ella a nivel mundial, cada día enfocan su atención, fundamentalmente, al capítulo de la prevención, particularmente, en el niño propenso a ser asmático. Se analizan las estadísticas relacionadas con el asma bronquial de los años 2001-2004 en Cuba, específicamente en lo referente a: prevalencia en pacientes dispensarizados por asma según grupos de edad y sexo; número de pacientes dispensarizados por asma según grupos de edad; tasa de prevalencia de pacientes dispensarizados por asma según provincias; así como las principales causas de egresos hospitalarios con diagnóstico de asma según estado al egreso. Se presentan recomendaciones prácticas para la prevención de enfermedades alérgicas en infantes con riesgo.Asthma is a frequent disease that is still difficult to diagnose, mainly in early childhood. It is also difficult to treat, in spite of the medical advances attained in the last years. For these reasons, the health public organizations and the bodies having to do with it at the world level focus their attention mainly on prevention, particularly in the child that is prone to be asthmatic. The statistics related to bronchial asthma from 2001 to 2004 in Cuba, specially what refers to the prevalence in patients suffering from asthma categorized by age and sex, the number of asthmatic patients categorized by age groups, the rate of prevalence of asthmatic patients categorized by province, as well as the main causes of hospital discharges with asthma diagnosis according to their state at discharge, are analyzed. Practical recommendations are given for the prevention of allergic diseases in infants at risk.

  3. Asthma control in Latin America: the Asthma Insights and Reality in Latin America (AIRLA survey El control del asma en América Latina: la encuesta de Percepción y Realidad del Asma en América Latina

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    Hugo Neffen

    2005-03-01

    Full Text Available OBJECTIVES: The aims of this survey were (1 to assess the quality of asthma treatment and control in Latin America, (2 to determine how closely asthma management guidelines are being followed, and (3 to assess perception, knowledge and attitudes related to asthma in Latin America. METHODS: We surveyed a household sample of 2 184 adults or parents of children with asthma in 2003 in 11 countries in Latin America. Respondents were asked about healthcare utilization, symptom severity, activity limitations and medication use. RESULTS: Daytime asthma symptoms were reported by 56% of the respondents, and 51% reported being awakened by their asthma at night. More than half of those surveyed had been hospitalized, attended a hospital emergency service or made unscheduled emergency visits to other healthcare facilities for asthma during the previous year. Patient perception of asthma control did not match symptom severity, even in patients with severe persistent asthma, 44.7% of whom regarded their disease as being well or completely controlled. Only 2.4% (2.3% adults and 2.6% children met all criteria for asthma control. Although 37% reported treatment with prescription medications, only 6% were using inhaled corticosteroids. Most adults (79% and children (68% in this survey reported that asthma symptoms limited their activities. Absence from school and work was reported by 58% of the children and 31% of adults, respectively. CONCLUSIONS: Asthma control in Latin America falls short of goals in international guidelines, and in many aspects asthma care and control in Latin America suffer from the same shortcomings as in other areas of the world.OBJETIVOS: Los objetivos de esta encuesta fueron 1 determinar la calidad del tratamiento y control del asma en América Latina, 2 determinar el grado de adherencia a las guías de tratamiento, y 3 determinar la percepción, los conocimientos y las actitudes con respecto al asma en América Latina. MÉTODO: La

  4. Caracterización epidemiológica de la descompensación aguda del asma bronquial

    Directory of Open Access Journals (Sweden)

    Yanin Arteaga Prado

    2013-08-01

    Full Text Available Introducción: el asma bronquial tiene una compleja fisiopatología que involucra la presencia en el paciente de factores genéticos de atopia, mecanismos inmunológicos disfuncionales. Objetivo: caracterizar la asociación de diversos aspectos epidemiológicos con la aparición de descompensaciones agudas del asma bronquial. Material y método: se realizó un estudio descriptivo y transversal a 118 pacientes del área de dos consultorios médicos del Policlínico Universitario "Hermanos Cruz" de la Ciudad de Pinar del Río durante el primer trimestre del 2012. Se comparó el grupo de pacientes que presentaron descompensaciones de la enfermedad con el grupo de pacientes que no se descompensó. Se aplicó un cuestionario para explorar las variables de interés. Para verificar la asociación entre variables se utilizó el estadígrafo ji cuadrado para un valor de significación estadística á=0.05. Resultados: las descompensaciones agudas fueron casi dos veces más frecuentes en el sexo femenino. De manera muy significativa (Z=3,26 p<0,01 una tercera parte de los asmáticos de su enfermedad; las amas de casa y los estudiantes fueron los más afectados. Solo el 38,1 % de los asmáticos tuvo un adecuado seguimiento por un especialista (clínico, pediatra, alergólogo o inmunólogo y de estos solo el 11,1 % presentaron descompensaciones agudas, en tanto se descompensó un 39,7 % de los que no tienen seguimiento especializado. Conclusiones: la degradación de las condiciones de la vivienda favoreció la aparición de descompensaciones agudas del asma. En tres cuartas partes de las casas había animales domésticos, existiendo una fuerte asociación entre esta condición y la aparición de descompensaciones agudas del paciente asmático.

  5. Hashimoto's thyroiditis following Graves' disease.

    Science.gov (United States)

    Umar, Husaini; Muallima, Nur; Adam, John M F; Sanusi, Harsinen

    2010-01-01

    Both Graves' disease and chronic thyroiditis (Hashimoto's thyroiditis) are autoimmune diseases of thyroid gland. Graves' disease is caused by stimulation of TSH receptor located on the thyroid gland by an antibody, which is known as TSH receptor antibody (TRAb). Furthermore, this may lead to hyperplasia and hyperfunction of the thyroid gland. On the contrary, the cause of Hashimoto's thyroiditis is thought due to a TSH stimulation-blocking antibody (TSBAb) which blocks the action of TSH hormone and subsequently brings damage and atrophy to thyroid gland. Approximately 15-20% of patients with Graves' disease had been reported to have spontaneous hypothyroidism resulting from the chronic thyroiditis (Hashimoto's disease). Pathogenesis for chronic thyroiditis following anti-thyroid drug treatment in patients with Graves' disease remains unclear. It has been estimated that chronic thyroiditis or Hashimoto's disease, which occurs following the Graves' disease episode is due to extended immune response in Graves' disease. It includes the immune response to endogenous thyroid antigens, i.e. thyroid peroxidase and thyroglobulin, which may enhance lymphocyte infiltration and finally causes Hashimoto's thyroiditis. We report four cases of chronic thyroiditis (Hashimoto's disease) in patients who have been previously diagnosed with Graves' hyperthyroidism. In three cases, Hashimoto's thyroiditis occurs in 7 to 25 years after the treatment of Grave's disease; while the other case has it only after few months of Grave's disease treatment. The diagnosis of Hashimoto's disease (chronic thyroiditis) was based on clinical manifestation, high TSHs level, positive thyroid peroxidase antibody and thyroglobulin antibody, and supported by positive results of fine needle aspiration biopsy. Moreover, the result of histopathological test has also confirmed the diagnosis in two cases. All cases have been successfully treated by levothyroxine treatment.

  6. Irritantes químicos y prevalencia de asma y bronquitis crónica en los trabajadores de los servicios de limpieza de los establecimientos de salud de la región Puno, Perú

    Directory of Open Access Journals (Sweden)

    Uriel Llanqui Gutiérrez

    2015-04-01

    Full Text Available Introducción: Estudios realizados en diversas partes del mundo evidencian la presencia de enfermedades respiratorias como asma y bronquitis crónica en trabajadores de los servicios de limpieza hospitalaria, por el uso de productos químicos como cloro y otros irritantes. Objetivo: Determinar la presencia de asma y bronquitis en los trabajadores de los servicios de limpieza de los hospitales de la región Puno, Perú, y establecer su asociación con irritantes químicos. Materiales y métodos: Estudio transversal con 201 trabajadores (tasa de respuesta 33%. El instrumento fue elaborado tomando en cuenta estudios europeos sobre condiciones de trabajo y estado de salud y, el cuestionario de asma de la European Community Respiratory Health Survey. Se estimaron asociaciones mediante odds ratios (OR. Resultados: Un alto porcentaje de entrevistados (64% reportó exposición a productos químicos. Asma y bronquitis fueron reportados con 18 y 11%, respectivamente. La evaluación estadística no mostró ningún predictor de enfermedades respiratorias; para sibilancias en el pecho OR: 0.72 (IC 95%: 0.18-2.87, ni para bronquitis crónica OR = 1.92 (IC 95%: 0.22-16.75. El género no se evidenció como confusor en este estudio. Conclusión: El estudio mostró ausencia de asociación entre la exposición a sustancias químicas y la presencia de enfermedades respiratorias, en los trabajadores de limpieza de establecimientos de salud; la causa probable sería la alta tasa de rotación de este personal, y el nivel de dilución de las sustancias químicas utilizadas.

  7. Inclusión educativa de alumnos con discapacidades graves y permanentes : análisis de un modelo : la Comunidad Valenciana (España = Educational inclusion of students with severe and permanent disabilities : analysis of a model : the Region of Valencia

    Directory of Open Access Journals (Sweden)

    Manuel López-Torrijo

    2014-09-01

    Full Text Available Este artículo analiza la inclusión educativa del alumnado con discapacidades graves y permanentes en la Comunidad Valenciana (España a través de los siguientes indicadores: concepción de las discapacidades graves y permanentes; responsabilidad de la escolarización y prestación de servicios; marco normativo; identificación, valoración y atención temprana; incidencia en la población; modelos y modalidades de escolarización; propuesta curricular; Centros y Unidades Específicos de Educación Especial; recursos personales y materiales; papel de las familias y financiación. Utiliza el método descriptivo en la revisión legislativa, documental, y bibliográfica, así como en el análisis de las fuentes estadísticas. Concluye señalando las mejoras inmediatas aplicables para una inclusión educativa real y de calidad.This article analyzes the educational inclusion of students with severe and permanent disabilities in the Region of Valencia with the following indicators: design of severe and permanent disabilities, regulatory framework, responsibility for providing schooling and services, identification and assessment of deficits, prevalence, proposed curriculum (model and modalities of care, special schools, human and material resources, role of families and funding. It utilizes the descriptive method in the legislative, documental and bibliographic revision, as well as in the analysis of statistical sources. The analysis concludes by pointing out the challenges that must guide future improvements to achieve a true educational equality.

  8. Hierro libre, transferrina y ferritina séricas de niños con desnutrición grave en terapia de recuperación nutricional. Turbo-Antioquia 2004

    Directory of Open Access Journals (Sweden)

    Claudia M. Velásquez R.

    2004-02-01

    Full Text Available El hierro libre contribuye a la producción de sustancias oxidativas que alteran la permeabilidad de la membrana celular y originan el edema característico del kwashiorkor (1. La OMS recomienda la suplementación con hierro para niños desnutridos, una vez recuperan el apetito.

  9. Mouse Models of Graves' Disease

    OpenAIRE

    Nagayama, Yuji

    2005-01-01

    Graves' disease is characterized by overstimulation of the thyroid gland with agonistic autoantibodies against the thyrotropin (TSH) receptor, leading to hyperthyroidism and diffuse hyperplasia of the thyroid gland. Our and other laboratories have recently established several animal models of Graves' hyperthyroidism with novel immunization approaches, i.e., in vivo expression of the TSH receptor by injection of syngeneic living cells co-expressing the TSH receptor and major histocompatibility...

  10. Recent activities of association of shape memory alloys (ASMA) in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Kobayashi, J [ASMA, Yokohama (Japan); Yamauchi, K [TOKIN Corp., Sendai (Japan); Miyashita, T [Nishimatsu Construction Co., Ltd., Yamato (Japan); Ohkata, I [Kato Hatsujo Kaisha, Ltd., Yokohama (Japan); Narumi, S [Sogo Hatsujo Co., Ltd. (Japan); Suzuki, Y [Furukawa Electric Co. Ltd., Tokyo (Japan)

    1995-12-01

    The Association of Shape Memory Alloys(ASMA) was established in 1983 and systematic surveys on the Ni-Ti and Cu based SMAs were carried out until 1986. The ASMA is now reorganized as a private association. In this paper, we briefly introduce several SMA products of the member companies and present a couple of products, a static rock breaking system and a thermostatic mixing valve in detail. (orig.).

  11. Recent activities of association of shape memory alloys (ASMA) in Japan

    International Nuclear Information System (INIS)

    Kobayashi, J.; Yamauchi, K.; Miyashita, T.; Ohkata, I.; Narumi, S.; Suzuki, Y.

    1995-01-01

    The Association of Shape Memory Alloys(ASMA) was established in 1983 and systematic surveys on the Ni-Ti and Cu based SMAs were carried out until 1986. The ASMA is now reorganized as a private association. In this paper, we briefly introduce several SMA products of the member companies and present a couple of products, a static rock breaking system and a thermostatic mixing valve in detail. (orig.)

  12. Roles of the Outer Membrane Protein AsmA of Salmonella enterica in the Control of marRAB Expression and Invasion of Epithelial Cells▿

    OpenAIRE

    Prieto, Ana I.; Hernández, Sara B.; Cota, Ignacio; Pucciarelli, M. Graciela; Orlov, Yuri; Ramos-Morales, Francisco; García-del Portillo, Francisco; Casadesús, Josep

    2009-01-01

    A genetic screen for suppressors of bile sensitivity in DNA adenine methylase (dam) mutants of Salmonella enterica serovar Typhimurium yielded insertions in an uncharacterized locus homologous to the Escherichia coli asmA gene. Disruption of asmA suppressed bile sensitivity also in phoP and wec mutants of S. enterica and increased the MIC of sodium deoxycholate for the parental strain ATCC 14028. Increased levels of marA mRNA were found in asmA, asmA dam, asmA phoP, and asmA wec strains of S....

  13. Dispneia, tosse e pieira… será asma?

    Directory of Open Access Journals (Sweden)

    Catarina Ferreira

    2014-12-01

    Discussão: O CAQ é uma variante do adenocarcinoma de ocorrência pulmonar rara. Tem origem a partir das glândulas seromucosas da mucosa traqueobrônquica e tem frequentemente localização central. O sintoma de apresentação mais comum é dispneia associada a sibilância, pieira e tosse, frequentemente interpretada como asma. Tem comportamento infiltrativo e crescimento lento. A terapêutica de eleição é a exérese total sempre que possível. As recidivas locais são frequentes. Apesar disso, tem bom prognóstico, com sobrevida de 91 e 76%, respectivamente aos 5 e aos 10 anos.

  14. Asma bronquial. Atención primaria de salud

    Directory of Open Access Journals (Sweden)

    Reinaldo Pino Blanco

    2010-12-01

    Full Text Available El siguiente trabajo define las pautas a seguir en la atención primaria de salud para logran un adecuado seguimiento y control de los pacientes que sufren enfermedades respiratorias crónicas y en particular el asma bronquial. Se realiza una revisión profunda de las principales guías para el manejo de la enfermedad, así como las mejores evidencias publicadas hasta la fecha.This paper sets out the guidelines in the primary health care to achieve an adequate monitoring and control of patients suffering from chronic respiratory diseases including bronchial asthma. A systematic review on the main guidelines to handle this disease and the best evidence published to this day are presented.

  15. Reporte de cinco casos de malaria neonatal grave por Plasmodium vivax en Urabá, Colombia

    Directory of Open Access Journals (Sweden)

    Juan Gabriel Piñeros

    2008-12-01

    Conclusión. Se trata de un reporte de cinco casos de malaria neonatal grave por P. vivax, especie que habitualmente no se relaciona con complicaciones, sin que existiera en ningún caso la sospecha clínica y con tratamiento inadecuado.

  16. [Grave's disease and stress].

    Science.gov (United States)

    Santos, A Matos; Nobre, E Lacerda; Garcia e Costa, J; Nogueira, P J; Macedo, Ana; De Castro, J Jácome; Teles, A Galvão

    2002-01-01

    In recent years, there have been many reports about a possible association between Stressful Life Events (SLE) and the onset of Graves' Disease (GD). Nevertheless, most papers have been criticised and no such association has yet been proven. To assess the possible associations between SLE and the onset of GD. Retrospective study of 62 subjects, divided into 2 groups of 31 each, GD (Gp1) and controls (Gp2). The patients in Gp1 had thyroid disease diagnosed within the last 12 months, with clinical and biochemical confirmation. In Gp2, psychopathological and endocrine disturbances had been ruled out. Each 2 group consisted of 9 males (29%) and 22 females (71%). The mean age was 38.48 + 10.9 in Gp1 and 41.1 + 11.8 in Gp2. SLE evaluation (number and impact) was reported for the 12 months preceding the onset of symptoms of thyroid disease. To assess SLE, we used the Life Experiences Survey-LES from Saranson, Johnson and Siegel (1978; 1985). Statistical analysis was done using Mann-Whitney and Kruskal-Wallis tests. Patients with GD had a significantly greater number of SLEs compared to Controls (p < .001). The number and impact of negative SLEs was significantly higher in Gp1 compared to Gp2 (p < .001). There were no significant differences between the groups in terms of the number and impact of both positive and neutral SLEs. The findings of this study support that SLEs may contribute to the precipitation of GD. We observed that patients with GD had significantly more negative events and experienced a greater negative impact from them prior to the onset of GD. The association of SLEs with GD is probably related to the association of stress with changes in the immune system, which can play an important role in the aetiology of thyrotoxicosis.

  17. Immunosuppression in Graves' ophthalmopathy

    International Nuclear Information System (INIS)

    Tian Rong; Kuang Anren; Qin Weishi; Zhang Huimin

    2000-01-01

    Objective: Graves' ophthalmopathy (GO) is a disease that seriously threatens the health of patients. But up to now, no optimal therapies have been established. Immunosuppressive treatment is usually used in the management of GO, but they may cause side effects. Recently, 99 Tc-MDP, commercially named 'Yun Ke', is used in the management of autoimmune disease. Therefore, a randomized trial was done to compare the values in the treatment of GO with between Yun Ke and immunosuppression. Methods: 42 consecutive patients with moderate or severe GO were randomly assigned to receive either Yun Ke therapy or immunosuppressive therapy. The degree of ocular involvement and responses to the treatment were evaluated by numerical scoring (ophthalmopathy index, OI) and clinical assessment. Therapy outcome was assessed 4 months after the start of treatment by the change in the highest NOSPECS class and OI. Data analysis was performed with the SPASS statistic software. Chi-square test was used to compare percentages, logistic regression was performed to identify which variables might correlated with the treatment outcome. Results: The remarkably effective outcome was observed in 14 (67%) cases in immunosuppression treated group and 13 (62%) cases in Yun Ke treated group. There were no significant differences in the degree of improvements in ocular involvements. There was a marked decrease of thyroid antibody titres in both groups. The variables found to correlated significantly with treatment outcome were thyroid antibody titres and GO activity. Side effects were more frequent and severe during immunosuppressive therapy. No side effects were found during Yun Ke treatment. Conclusion: Yun Ke and immunosuppression appeared to be equally effective in the management of GO, but Yun Ke is safer for patients during treatment

  18. Nifedipine Asma y Nifedipina: estudio comparativo del efecto profiláctivo de la Nifedipina frente al Ketotifeno y placebo en Asma Alérgica Infantil

    Directory of Open Access Journals (Sweden)

    Fernando Montoya

    1988-02-01

    affinity for the respiratory tract and better blocking effects are synthesized they might become the elective therapeutic choice for these patients.

    Se presentan los resultados de un estudio doble ciego, al azar, que comparó los efectos de la Nifedipina, una dihidropiridina antagonista del calcio, de amplia utilización cardiovascular, con los del Ketotifeno y los de un placebo; cada uno de ellos fue administrado por vía oral cada 12 horas, durante 4 meses, a un grupo de 20 niños mayores de 5 años con asma alérgica de una evolución mínima de 2 años; el estudio se llevó a cabo en el Servicio de Alergias del Hospital Universitario San Vicente de Paúl, de Medellín, Colombia, entre julio de 1984 y diciembre de 1986. La Nifedipina produjo disminución de la frecuencia de las crisis en 17 pacientes (85% y de su intensidad y duración en 16 (80%; en esta misma proporción (80% se disminuyó el consumo de broncodilatadores; 18 pacientes (90% informaron efectos benéficos de la Nifedipina y la mejoría, evaluada por el médico, se halló en 14 (70%. No hubo con la Nifedipina modificaciones del pulso ni de la presión arterial ni, tampoco, de 14 pruebas de función pulmonar; los efectos secundarlos fueron mínimos y autolimitados. Los resultados obtenidos con la Nifedipina fueron estadísticamente semejantes a los del Ketotifeno y, los de ambos, significativamente superiores a los logrados con el placebo (pasma alérgica Infantil leve o moderada, dado su comportamiento similar al del Ketotifeno que es de eficacia reconocida en este campo; en un futuro los antagonistas del calcio pueden llegar a ser el tratamiento de elección del paciente asmático si se logra sintetizar moléculas con mayor afinidad por las v las respiratorias y de efectos antagónicos superiores.

  19. INDICADORES CLÍNICOS DE PADRÃO RESPIRATÓRIO INEFICAZ EM CRIANÇAS COM ASMA

    Directory of Open Access Journals (Sweden)

    JOYCE CAROLLE BEZERRA CAVALCANTE

    2010-01-01

    Full Text Available Un estudio transversal, realizado con 147 niños internados con diagnóstico médico de asma, en un Hospital Infantil Público de Fortaleza-CE, fue desarrollado con el objetivo de analizar el esmero de las características definidoras del diagnóstico de Enfermería “Patrón respiratorio ineficaz - PRI” en niños asmáticos. Las características definidoras más frecuentes fueron la disnea (56,4% y la frecuencia respiratoria/min aumentada (50,3%. El diagnóstico de enfermería PRI estuvo presente en 36,1% de la muestra. La característica definidora de mayor sensibilidad fue la disnea. Las características de mayor especifi- cidad para este diagnóstico fueron: pulsación de las narinas, asumir posición de tres puntos y diámetro antero-posterior au- mentado. Se llegó a la conclusión de que los estudios que contribuyen a configurar el perfil de las características definidoras más comunes a una población particular deben ser estimulados, ya que sirven como guía para la práctica de enfermería.

  20. Fatores associados ao controle da asma em pacientes pediátricos em centro de referência Factores asociados al control del asma en pacientes pediátricos en centro de referencia Factors associated with asthma control in a pediatric reference center

    Directory of Open Access Journals (Sweden)

    Vanessa Mika Kinchoku

    2011-12-01

    átrico especializado. MÉTODOS: Estudio transversal de pacientes asmáticos ambulatoriales, para los que se suministraban medicaciones profilácticas gratuitamente. La clasificación del asma, las etapas de tratamiento y la evaluación del control siguieron las IV Directrices Brasileñas para el Manejo del Asma, 2006. Los factores evaluados fueron: otras alergias, obesidad, inmunodeficiencias, reflujo gastroesofágico y sensibilización alérgica, siendo comparados pacientes controlados o no respecto a la etapa del tratamiento, obesidad y la sensibilización alérgica. RESULTADOS: Se analizaron a 300 pacientes con asma (1,38M:1F; mediana de edad de 10,8 años, mediana del inicio de los síntomas de 1,0 año. La atopía estaba presente en el 77,8% de los padres y/o hermanos. Antecedentes personales de enfermedades alérgicas ocurrieron en 292 pacientes (95,6% rinitis, 27% dermatitis atópica, 18,3% conjuntivitis alérgica, 6% alergia alimentar. Se diagnosticaron 7 casos de deficiencia de IgA (2,3% de DIgA y 4 de IgG2; obesidad en 37/253 (14,6%, siendo que el sobrepeso y la obesidad estuvieron asociados a la falta de control (p=0,023. En 118 pacientes con multisensibilización predominaron casos no controlados (18,6% frente a 9,8% (p=0,049; OR 1,9; IC95% 1,03-3,50. Entre los 180 casos (60,2% en tratamiento en las etapas 3 y 4, 122 estaban controlados (45,0% y 112 (41,3%, parcialmente controlados. CONCLUSIONES: La rinitis fue la alergia más asociada al asma y la prevalencia de DIgA fue 20 veces superior a la población general. El control parcial o total de los síntomas del asma se obtuvo en el 86,3% de los casos. Obesidad/sobrepeso y multisensibilización fueron asociadas a la falta de control del asma.OBJECTIVE: To describe the epidemiological and clinical data and factors associated with asthma control of asthmatic patients followed at a pediatric reference center. METHODS: Cross-sectional study including asthmatic outpatients receiving prophylactic medications from the institution

  1. High ASMA+ Fibroblasts and Low Cytoplasmic HMGB1+ Breast Cancer Cells Predict Poor Prognosis.

    Science.gov (United States)

    Amornsupak, Kamolporn; Jamjuntra, Pranisa; Warnnissorn, Malee; O-Charoenrat, Pornchai; Sa-Nguanraksa, Doonyapat; Thuwajit, Peti; Eccles, Suzanne A; Thuwajit, Chanitra

    2017-10-01

    The influence of cancer-associated fibroblasts (CAFs) and high mobility group box 1 (HMGB1) has been recognized in several cancers, although their roles in breast cancer are unclear. The present study aimed to determine the levels and prognostic significance of α-smooth muscle actin-positive (ASMA + ) CAFs, plus HMGB1 and receptor for advanced glycation end products (RAGE) in cancer cells. A total of 127 breast samples, including 96 malignant and 31 benign, were examined for ASMA, HMGB1, and RAGE by immunohistochemistry. The χ 2 test and Fisher's exact test were used to test the association of each protein with clinicopathologic parameters. The Kaplan-Meier method or log-rank test and Cox regression were used for survival analysis. ASMA + fibroblast infiltration was significantly increased in the tumor stroma compared with that in benign breast tissue. The levels of cytoplasmic HMGB1 and RAGE were significantly greater in the breast cancer tissue than in the benign breast tissues. High ASMA expression correlated significantly with large tumor size, clinical stage III-IV, and angiolymphatic and perinodal invasion. In contrast, increased cytoplasmic HMGB1 correlated significantly with small tumor size, pT stage, early clinical stage, luminal subtype (but not triple-negative subtype), and estrogen receptor and progesterone receptor expression. The levels of ASMA (hazard ratio, 14.162; P = .010) and tumor cytoplasmic HMGB1 (hazard ratio, 0.221; P = .005) could serve as independent prognostic markers for metastatic relapse in breast cancer patients. The ASMA-high/HMGB1-low profile provided the most reliable prediction of metastatic relapse. We present for the first time, to the best of our knowledge, the potential clinical implications of the combined assessment of ASMA + fibroblasts and cytoplasmic HMGB1 in breast cancer. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  2. Grave's disease 1835-2002.

    Science.gov (United States)

    Weetman, A P

    2003-01-01

    This brief review describes the history of Graves' disease, starting with the original descriptions by Parry, Graves and von Basedow. The true aetiology of the disorder was uncovered in the 1950s and 1960s, based on the search for a novel thyroid stimulator which turned out to be an immunoglobulin G autoantibody. Assays for these thyroid stimulatory antibodies have been continually refined and their epitopes on the thyroid stimulating hormone receptor are increasingly well characterized. We also understand far more about the genetic and environmental susceptibility factors that predispose to disease, and even thyroid-associated ophthalmopathy has now been better defined as primarily a T-cell-mediated disease resulting from cytokine stimulation of orbital fibroblasts. These advances should improve treatment options for Graves' disease in the foreseeable future.

  3. Roles of the outer membrane protein AsmA of Salmonella enterica in the control of marRAB expression and invasion of epithelial cells.

    Science.gov (United States)

    Prieto, Ana I; Hernández, Sara B; Cota, Ignacio; Pucciarelli, M Graciela; Orlov, Yuri; Ramos-Morales, Francisco; García-del Portillo, Francisco; Casadesús, Josep

    2009-06-01

    A genetic screen for suppressors of bile sensitivity in DNA adenine methylase (dam) mutants of Salmonella enterica serovar Typhimurium yielded insertions in an uncharacterized locus homologous to the Escherichia coli asmA gene. Disruption of asmA suppressed bile sensitivity also in phoP and wec mutants of S. enterica and increased the MIC of sodium deoxycholate for the parental strain ATCC 14028. Increased levels of marA mRNA were found in asmA, asmA dam, asmA phoP, and asmA wec strains of S. enterica, suggesting that lack of AsmA activates expression of the marRAB operon. Hence, asmA mutations may enhance bile resistance by inducing gene expression changes in the marRAB-controlled Mar regulon. In silico analysis of AsmA structure predicted the existence of one transmembrane domain. Biochemical analysis of subcellular fractions revealed that the asmA gene of S. enterica encodes a protein of approximately 70 kDa located in the outer membrane. Because AsmA is unrelated to known transport and/or efflux systems, we propose that activation of marRAB in asmA mutants may be a consequence of envelope reorganization. Competitive infection of BALB/c mice with asmA(+) and asmA isogenic strains indicated that lack of AsmA attenuates Salmonella virulence by the oral route but not by the intraperitoneal route. Furthermore, asmA mutants showed a reduced ability to invade epithelial cells in vitro.

  4. Optimal management of Graves orbitopathy: a multidisciplinary approach

    NARCIS (Netherlands)

    Soeters, M. R.; van Zeijl, C. J. J.; Boelen, A.; Kloos, R.; Saeed, P.; Vriesendorp, T. M.; Mourits, M. P.

    2011-01-01

    Graves' thyroid disease is a relatively common disorder in endocrinology and general internal medicine practice. Graves' hyperthyroidism is mediated by circulating stimulating autoantibodies. Up to 60% of patients with Graves' hyperthyroidism develop some form of Graves' orbitopathy. Immune

  5. Graves disease hyperthyroidism and glycometabolism

    International Nuclear Information System (INIS)

    Sun Qiting; Zhao Deshan

    2010-01-01

    The Patients with Graves disease hyperthyroidism are often accompanied by disorder of glycometabolism. β-cell dysfunction and insulin resistance play a main role in this disease, while the immune and genetic factors are also relevant with the disease. The blood glycose level can become normal gradually with the recovery of thyroid hormone after 131 I and antithyroid drug treatment. Therefore, the blood glycose level could be improved and complications could be prevented by early treatment in the patients with Graves disease hyperthyroidism accompanied with glycometabolism disorder is helpful for improving the blood glycose level. (authors)

  6. Temperatura do ar exalado, um novo biomarcador no controle da asma: um estudo piloto Exhaled breath temperature, a new biomarker in asthma control: a pilot study

    Directory of Open Access Journals (Sweden)

    Raul Emrich Melo

    2010-12-01

    Full Text Available OBJETIVO: Avaliar se a temperatura do ar exalado (TAE, medida por um método não invasivo, é efetiva no monitoramento de pacientes com asma não controlada. MÉTODOS: Estudo piloto com nove pacientes (sete mulheres e dois homens; média de idade: 39 anos com diagnóstico de asma por pelo menos um ano e sem uso de tratamento de manutenção por pelo menos três meses antes do início do estudo. Na primeira visita, os pacientes foram submetidos à espirometria e à medida da TAE. Todos os pacientes foram orientados a iniciar tratamento com budesonida/formoterol (200/6 µg inalatório a cada 12 h por seis semanas. Além disso, os pacientes com asma grave (VEF1 OBJECTIVE: To evaluate whether the exhaled breath temperature (EBT, measured by a noninvasive method, is an effective means of monitoring patients with uncontrolled asthma. METHODS: A pilot study comprising nine patients (seven women and two men; mean age: 39 years diagnosed with asthma at least one year prior to the beginning of the study and not having been under maintenance therapy for the last three months. In the first visit, the patients underwent spirometry and measurement of EBT. The patients were then instructed to use inhaled budesonide/formoterol (200/6 µg every 12 h for six weeks. In addition, the patients with severe asthma (FEV1 < 60% of predicted were instructed to use oral prednisolone (40 mg/day for five days. After six weeks, the patients underwent the same tests. RESULTS: All of the patients reported an improvement in the symptoms of asthma, as confirmed by a statistically significant increase in FEV1 from the first to the second visit (mean, 56.1% vs. 88.7% of predicted; p < 0.05. Five patients used oral prednisolone for the first five days of the treatment period. Six patients used additional doses of inhaled budesonide/formoterol (mean duration, 2.5 weeks. The EBT decreased significantly from the first to the second visit (mean EBT: 35.1ºC vs. 34.1ºC; p < 0

  7. Graves' disease and Thyroid anaplasic carcinoma

    International Nuclear Information System (INIS)

    Guerrero E, Helena; Quintero A, Flor Maria; Carmona C, Antonio

    1992-01-01

    A case of a 34 year-old patient is presented, who was diagnosed with Graves' disease and developed a thyroid anaplastic carcinoma from a clinically detected nodular mass. The incidence of thyroid cancer associated with Graves' disease is revisited

  8. Death by suicide in Graves' disease and Graves' orbitopathy

    DEFF Research Database (Denmark)

    Ferløv-Schwensen, Charlotte; Brix, Thomas Heiberg; Hegedus, Laszlo

    2017-01-01

    BACKGROUND: Graves' disease is associated with excess morbidity and mortality, but little is known about unnatural manners of death and the potential relation with Graves' orbitopathy. Here we investigate the risk of unnatural death in Graves' patients with orbitopathy (GO) and without (GD), comp...... in the pathophysiological mechanisms of suicidal behavior. Beyond independent confirmation, reasons for this need to be explored in order to introduce preventive measures....... with GD, and 3,965 with GO were identified and matched for age and gender with four subjects from the background population. Manner of death was identified and hazard ratios (HR) for mortality due to unnatural deaths (accident, suicide, violence/homicide, and unknown) were calculated using Cox regression...... analyses, adjusted for pre-existing somatic and psychiatric morbidity. RESULTS: In Graves' disease overall there was an increased risk of death from unknown unnatural manners [HR: 2.01 (95% confidence interval: 1.17-3.45); P=0.012] and of suicide, although the latter difference was not with certainty...

  9. Temporal relationship between onset of Graves' ophthalmopathy and onset of thyroidal Graves' disease

    NARCIS (Netherlands)

    Wiersinga, W. M.; Smit, T.; van der Gaag, R.; Koornneef, L.

    1988-01-01

    The temporal relationship between the onset of Graves' ophthalmopathy and the onset of thyroidal Graves' disease was evaluated in 125 consecutive patients with Graves' ophthalmopathy. Thyroidal Graves' disease--past or present--was clinically evident in 99 patients (79%): hyperthyroidism in 3 cases.

  10. El componente educativo en el abordaje integral del asma bronquial The educational component in an integrated approach to bronchial asthma

    Directory of Open Access Journals (Sweden)

    María Paola Fasciglione

    2010-04-01

    Full Text Available El asma bronquial es una enfermedad inflamatoria crónica de las vías respiratorias cuya prevalencia está aumentando en el mundo. Actualmente no se dispone de un tratamiento curativo, y el objetivo principal de todo abordaje es el control de la enfermedad y la optimización de la calidad de vida de los pacientes. En este sentido, durante las últimas décadas se han estado implementando y evaluando programas de intervención complementarios a los tratamientos médicos convencionales. Gran parte de éstos consisten en intervenciones educativas o incluyen algún tipo de componente educativo. El objetivo del presente trabajo fue analizar las características y el impacto de las intervenciones educativas en el asma, a través de: a revisión actualizada sobre los diferentes tipos de intervenciones educativas desarrolladas e implementadas para el asma; b identificación de aspectos comunes a todas estas intervenciones; c análisis de los hallazgos de la investigación referidos a su impacto sobre la salud y la calidad de vida de los pacientes. Se concluye que las intervenciones educativas son efectivas para mejorar la salud y la calidad de vida de los pacientes con asma, y para reducir el uso y el costo de recursos sanitarios. Estos hallazgos señalan la importancia de incluir el componente educativo como parte esencial del abordaje integral de esta población clínica. Asimismo, la complejidad inherente al proceso educativo pone de manifiesto la necesidad del trabajo conjunto y complementario entre diferentes profesionales de la salud.Bronchial asthma is an inflammatory chronic disease of the respiratory tract whose prevalence is increasing worldwide. Since there is no curative treatment available, the principal objective of every approach is to control the disease and to improve the quality of life of patients. Over the last few decades, intervention programs supplementing conventional medical treatments have been tested and implemented. The

  11. Asma em escolares do Recife - comparação de prevalências: 1994-95 e 2002 Asthma in schoolchildren from Recife, Brazil. Prevalence comparison: 1994-95 and 2002

    Directory of Open Access Journals (Sweden)

    Murilo C. A. Britto

    2004-01-01

    Full Text Available OBJETIVOS: Descrever a prevalência atual (2002 de asma e suas variantes em escolares da cidade do Recife, comparando os dados com o período de 1994-95; analisar a relação entre instrução materna e o surgimento ou o agravamento da asma; e avaliar a acurácia diagnóstica da prevalência anual de sibilância como indicador de asma. MÉTODO: Em um corte transversal, estudou-se, por questionário escrito, uma amostra probabilística de escolares de 13 e 14 anos em Recife, em 1994-95 (n = 3.086 e 2002 (n = 2.774, como parte do projeto ISAAC (International Study of Asthma and Allergies in Childhood. RESULTADOS: Em 1994-95 e 2002, as prevalências foram, respectivamente: cumulativa de asma referida, 21 e 18,2%; cumulativa de sibilância, 39 e 38%; anual de sibilância, 19,7 e 19,4%; anual de tosse equivalente de asma, 31 e 38%; anual de sibilância desencadeada por exercício, 20,6 e 23,8%. A prevalência anual de crises, estratificada em 1 a 3, 4 a 12 e mais de 12 foi: 16,3, 2,7 e 1% em 1994-95 e 15,2, 1,2 e 0,4% em 2002. A prevalência anual de crises que comprometeram o sono foi, respectivamente, de 13 e 10,3%; a prevalência de crises com prejuízo da fala foi de 4,8 e 4,1%. Nível mais elevado de instrução materna associou-se a maior prevalência cumulativa de asma referida, prevalência cumulativa e anual de sibilância. CONCLUSÕES: A prevalência de asma e suas formas graves é elevada em escolares adolescentes do Recife e está associada a maior instrução materna.OBJECTIVES: To describe the prevalence of asthma and asthma variants in schoolchildren from Recife in 2002, and to compare these data with data from 1994-95; to analyze the relationship between maternal schooling and the presence of asthma or worsening asthma; and to evaluate the diagnostic accuracy of the yearly prevalence of wheezing as an asthma indicator. METHODS: Cross-sectional study. A probabilistic sample of 3,086 and 2,774 13- and 14-year-old students answered a

  12. Secrets of a Mass Grave

    Science.gov (United States)

    Ament, Caitlin Marie; Graham, Theodore J.

    2017-01-01

    This article presents a unit of study in which students examine skeletons and draw conclusions from the evidence they find in a simulated mass grave. The activity involves the foundation of forensic anthropology--interpreting the structure of skeletal remains to determine sex, age, height, and possible cause of death. Working through a series of…

  13. Medical management of Graves' ophthalmopathy

    NARCIS (Netherlands)

    Prummel, M. F.; Wiersinga, W. M.

    1995-01-01

    In most patients with Graves' hyperthyroidism the eye signs are self-limiting and mostly subclinical. However, about one-third of the patients have clinically relevant ophthalmopathy, which can be disabling and disfiguring. The mechanical causes of the symptoms and signs of the eye disease are

  14. Biologiske behandlingsmuligheder ved Graves' oftalmopati

    DEFF Research Database (Denmark)

    El Fassi, Daniel; Nielsen, Claus Henrik; Hegedüs, Laszlo

    2008-01-01

    The current medical treatment options for Graves' ophthalmopathy (GO) are unsatisfactory. Recent treatment of GO patients with the B-lymphocyte depleting monoclonal antibody rituximab or with the anti-tumor necrosis factor-alpha agents etanercept and infliximab has shown promising results. We...

  15. Acerca de una manía pseudo-alucinatoria grave, desarrollada en un palúdico sifilítico, con caracteres evolutivos finales de delirio agudo mortal

    Directory of Open Access Journals (Sweden)

    Luis Jaime Sánchez

    1938-03-01

    de Dios, el 3 de noviembre de 1937.--Bogotá Neftalí G. de 22 años de edad, natural de Manzanares (Caldas soltero y agricultor de profesión, ingresa al servicio de enfermedades tropicales el 18 de septiembre. Interrogado acerca de sus antecedentes hereditarios, no anota nada que sirva. Entre sus antecedentes personales, refiere haber contraído una sífilis hace tres meses, la cual se trató, mal, empleando para ello dos inyecciones de neosalvarsan y una de bismuto coloidal. No da ningún antecedente alcohólico ni recuerda otro alguno morboso. Cuanto a la evolución de la enfermedad actual, el paciente anota lo siguiente: Con ocasión de un viaje a Villavicencio en donde trabajaba en una hacienda en calidad de agricultor, Neftalí G. experimentó súbitamente una sensación de malestar muy acentuado, seguido de sensación febril y de un calofrío que le duró dos horas y que fue seguido de abundante sudor. Esta fiebre le repetía todos los días a hora "'distinta, y le duraba más o menos hora y media. Imposibilitado para seguir trabajando resolvió hospitalizarse en Bogotá, y en el camino de Villavicencio a la capital, el enfermo no pasó ningún día sin que dejara de experimentar el mismo ataque febril.

  16. Encuesta sobre cambios en el manejo y tratamiento del asma bronchial Survey on changes in asthma treatment and management

    Directory of Open Access Journals (Sweden)

    Guillermo A. Raimondi

    2004-06-01

    Full Text Available Se realizó una encuesta a 518 especialistas de enfermedades respiratorias de un listado de la totalidad del país. Esta se refería al manejo y al tratamiento del acceso agudo y especialmente al asma estable, en adultos y en niños mayores de 6 años. Se obtuvieron 198 respuestas (38.2% de los cuestionarios enviados. Se compararon los resultados con los obtenidos en una encuesta realizada en 1994. Las respuestas se evaluaron como 0 (nunca, 1 (algunas veces, 2 (a menudo, 3 (siempre. Con estos valores se calculó un puntaje medio. Respecto a 1994 se encontró una buena tendencia referente al enfoque diagnóstico con más utilización de la prueba de reversibilidad a los broncodilatadores (2.74 ±2.3 vs 2.30±1.05 y la prueba terapéutica con corticoides (1.26±0.96 vs 0.98±0.84 y menor utilización de las pruebas cutáneas (0.50±0.83 vs 0.88±1.08. Referente al consejo de utilizar la sintomatología o el descenso del pico flujo espiratorio para reconocer el ataque del asma, ambos mejoraron significativamente (2.65±0.66 vs 2.29±0.90 y 1.93±1.05 vs 1.51±1.20, respectivamente. Criterios objetivos para evaluar el ataque de asma no siempre son utilizados por parte del médico y no mejoraron respecto a 1994 (2.14±1.04 vs 2.13±0.70. Referente al tratamiento en agudo, este enfoque mejoró notablemente con la casi totalidad de los encuestados que recomiendan b2 agonistas inhalados tanto en adultos como en niños (primera opción de tratamiento 85.3 vs 57.5% y 81.0 vs 63.4%, respectivamente. En el tratamiento de mantenimiento, se observó una mayor utilización de corticoides inhalados, sobre todo en los niños (2.09±1.01 vs 1.61±1.00, con dosis ahora correctas. Se observó menor utilización de b2 agonistas de acción corta en el tratamiento continuo, 0.40±0.78 vs 1.23±1.10 y 0.21±0.58 vs 1.23±1.00 en adultos y niños, respectivamente. A pesar de esta tendencia positiva en el manejo y tratamiento de asma bronquial no todo está de acuerdo

  17. Faktor Risiko Asma Pada Murid Sekolah Dasar Usia 6-7 Tahun di Kota Padang

    Directory of Open Access Journals (Sweden)

    Afdal .

    2012-11-01

    Full Text Available Abstrak Latar belakang : Asma merupakan penyakit kronik yang sering dijumpai pada anak. Dilaporkan bahwa prevalens asma meningkat pada anak maupun dewasa. Usia 6-7 tahun merupakan periode dimana prevalens asma dan angka kunjungan ke rumah sakit karena asma lebih tinggi. Terjadinya asma dianggap sebagai interaksi yang kompleks antara faktor genetik dan faktor lingkungan. Faktor genetik sudah dibuktikan dari penelitian-penelitian sebelumnya, tetapi karakteristik faktor risiko lingkungan pada asma belum jelas. Apabila melihat derajat peningkatan kejadian asma, tidak mungkin hanya faktor genetik yang berperan, tetapi peran faktor lingkungan justru yang lebih besar. Tujuan : Untuk mengetahui prevalens dan faktor risiko asma pada anak SD usia 6-7 tahun di Kota Padang.Metoda : Suatu penelitian cross sectional di 20 SD di Kota Padang pada bulan Juni – November 2009 dengan jumlah sampel 879 orang. Terhadap setiap subjek dilakukan penelitian yaitu pembagian kuisioner ISAAC (international study of asthma and allergies in childhood untuk orang tua. Analisis data dilakukan dengan uji chi-square untuk variabel katagorik dan analisis multivariat dengan regresi logistik. Data dianalisis menggunakan peranti lunak komputer.Hasil : Prevalens asma pada murid SD usia 6-7 tahun di Kota Padang berdasarkan kuisioner ISAAC sebesar 8%. Faktor yang paling dominan berpengaruh terhadap kejadian asma adalah atopi ayah atau ibu, diikuti faktor berat badan lahir dan kebiasaan merokok pada ibu serta pemberian obat parasetamol. Sedangkan pemberian ASI dan kontak dengan unggas merupakan faktor protektif terhadap kejadian asma. Kata kunci: faktor risiko, asma, sekolah dasar Abstract Background: Background Asthma is a common chronic disease in children. It had been reported that the prevalence of asthma in children and adults was increasing. The age of 6-7 years is the period where the prevalence and the number of visits to the hospital because of asthma are higher. The

  18. CDC: Consejos de exfumadores: El Consejo de Jessica Sobre el Asma PSA (:30)

    Centers for Disease Control (CDC) Podcasts

    La exposición al humo de segunda mano puede provocar un ataque de asma que puede ser mortal. Este anuncio de servicio público de 30 segundos de la campaña de los CDC “Consejos de exfumadores”, muestra a Jessica, la madre de un niño pequeño que tiene ataques de asma por la exposición al humo de segunda mano. Su consejo es que las personas no sientan pena de decirles a otras que no fumen cerca de sus hijos.

  19. Thyroid surgery for Graves' disease and Graves' ophthalmopathy.

    Science.gov (United States)

    Liu, Zi Wei; Masterson, Liam; Fish, Brian; Jani, Piyush; Chatterjee, Krishna

    2015-11-25

    Graves' disease is an autoimmune disease caused by the production of auto-antibodies against the thyroid-stimulating hormone receptor, which stimulates follicular cell production of thyroid hormone. It is the commonest cause of hyperthyroidism and may cause considerable morbidity with increased risk of cardiovascular and respiratory adverse events. Five per cent of people with Graves' disease develop moderate to severe Graves' ophthalmopathy. Thyroid surgery for Graves' disease commonly falls into one of three categories: 1) total thyroidectomy, which aims to achieve complete macroscopic removal of thyroid tissue; 2) bilateral subtotal thyroidectomy, in which bilateral thyroid remnants are left; and 3) unilateral total and contralateral subtotal thyroidectomy, or the Dunhill procedure. Recent American Thyroid Association guidelines on treatment of Graves' hyperthyroidism emphasised the role of surgery as one of the first-line treatments. Total thyroidectomy removes target tissue for the thyroid-stimulating hormone receptor antibody. It controls hyperthyroidism at the cost of lifelong thyroxine replacement. Subtotal thyroidectomy leaves a thyroid remnant and may be less likely to lead to complications, however a higher rate of recurrent hyperthyroidism is expected and revision surgery would be challenging. The choice of the thyroidectomy technique is currently largely a matter of surgeon preference, and a systematic review of the evidence base is required to determine which option offers the best outcomes for patients. To assess the optimal surgical technique for Graves' disease and Graves' ophthalmopathy. We searched the Cochrane Library, MEDLINE and PubMed, EMBASE, ClinicalTrials.gov, and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP). The date of the last search was June 2015 for all databases. We did not apply any language restrictions. Only randomised controlled trials (RCTs) involving participants with a diagnosis

  20. Avaliação do questionário de controle da asma validado para uso no Brasil Evaluation of the asthma control questionnaire validated for use in Brazil

    Directory of Open Access Journals (Sweden)

    Mylene Leite

    2008-10-01

    Full Text Available OBJETIVO: Avaliar se a versão em língua portuguesa do Asthma Control Questionnaire (ACQ, Questionário de Controle da Asma é um instrumento válido para medir o controle da asma em pacientes adultos ambulatoriais no Brasil. MÉTODOS: Foram avaliados 278 pacientes ambulatoriais com diagnóstico de asma. Todos os pacientes, durante a primeira visita, responderam ao questionário, foram submetidos à espirometria e avaliados clinicamente por um médico para a caracterização do controle da doença. Foram analisadas as versões do questionário com 5, 6 e 7 questões, utilizando dois escores distintos (0,75 e 1,50 como pontos de corte. RESULTADOS: Dos 278 pacientes, 77 (27,7% tinham asma intermitente, 39 (14,0% asma persistente leve, 40 (14,4% asma persistente moderada e 122 (43,9% asma persistente grave. A sensibilidade do questionário para identificar asma não-controlada variou de 77% a 99% e a especificidade variou de 36% a 84%. O valor preditivo positivo variou de 73% a 90%, e o valor preditivo negativo variou de 67% a 95%. A razão de verossimilhança positiva variou de 1,55 a 4,81, e a razão de verossimilhança negativa variou de 0,03 a 0,27. Nas versões do ACQ com 5 e 6 questões, o coeficiente de correlação intraclasse foi de 0,92, e estas versões foram responsivas a mudanças no quadro clínico dos pacientes. CONCLUSÕES: O ACQ, nas suas três versões, teve boa capacidade de discriminar indivíduos com asma não-controlada daqueles com asma controlada. As versões com 5 e 6 questões apresentaram também boa reprodutibilidade e responsividade. Trata-se, portanto, de um instrumento válido para avaliação do controle da asma em pacientes adultos ambulatoriais no Brasil.OBJECTIVE: To evaluate whether the Portuguese version of the Asthma Control Questionnaire (ACQ is a valid instrument to measure asthma control in adult outpatients in Brazil. METHODS: We selected 278 outpatients diagnosed with asthma. All of the patients completed

  1. O impacto da genética na asma infantil Impact of genetics in childhood asthma

    Directory of Open Access Journals (Sweden)

    Leonardo A. Pinto

    2008-08-01

    Full Text Available OBJETIVO: Apresentar os resultados dos estudos mais importantes e recentes sobre a genética da asma. Estes dados devem auxiliar os clínicos gerais a compreender o impacto da genética sobre este distúrbio complexo e como os genes e polimorfismos influenciam a asma e a atopia. FONTES DOS DADOS: Os dados foram coletados do banco de dados MEDLINE. Os estudos de associação genética foram selecionados do Genetic Association Database, um repositório de estudos de associação genética de doenças e distúrbios complexos organizado pelo National Institutes of Health. SÍNTESE DOS DADOS: Considerando os dados de diversos importantes estudos de gêmeos sobre a genética da asma, a heritabilidade, que mensura a contribuição dos fatores genéticos para a variância da asma, pode ser estimada entre 0,48 e 0,79. Uma grande quantidade de estudos de associação genética tentou identificar genes de susceptibilidade à asma. Os resultados mais replicados nos estudos de associação genética envolvem as cinco regiões do genoma humano a seguir: 5q31-32, 6p21, 11q12-13, 16p11-12, e 20p13. Recentemente, outro gene de susceptibilidade à asma (ORMDL3, considerado determinante crítico para a asma infantil, foi identificado por um estudo genômico de associação. CONCLUSÕES: É possível estimar que a contribuição genética à asma varia entre 48 e 79%. Diversos loci parecem influenciar a susceptibilidade à asma. Os genes localizados no cromossomo 5q (ADRB2, IL13 e IL4 e o gene ORMDL3, no cromossomo 17, identificado recentemente, parecem ser determinantes para a asma infantil. O diagnóstico e a farmacogenética podem ser as primeiras implicações clínicas de estudos extensivos sobre a genética da asma.OBJECTIVE: To present the most important and recent results of studies on asthma genetics. These data may help general physicians understand the impact of genetics on this complex disorder and how genes and polymorphisms influence asthma and atopy

  2. Genetic susceptibility to Grave's disease.

    Science.gov (United States)

    Li, Hong; Chen, Qiuying

    2013-06-01

    The variety of clinical presentations of eye changes in patients with Graves' disease (GD) suggests that complex interactions between genetic, environmental, endogenous and local factors influence the severity of Graves' ophthalmopathy (GO). It is thought that the development of GO might be influenced by genetic factors and environmental factors, such as cigarette smoking. At present, however, the role of genetic factors in the development of GO is not known. On the basis of studies with candidate genes and other genetic approaches, several susceptibility loci in GO have been proposed, including immunological genes, human leukocyte antigen (HLA), cytotoxic T-lymphocyte antigen-4 (CTLA-4), regulatory T-cell genes and thyroid-specific genes. This review gives a brief overview of the current range of major susceptibility genes found for GD.

  3. Asma y deficiencia de subclases de IgG Asthma and IgG subclases deficiency

    Directory of Open Access Journals (Sweden)

    Lucía Santamaría Ortiz

    1995-04-01

    Full Text Available

    Se estudiaron 45 pacientes asmáticos adultos de difícil manejo, de más de 5 años de evolución, 37 de ellos esteroide dependientes y 8 no dependientes, con asma alérgica o intrínseca y algunos con Infecciones respiratorias recurrentes de predominio viral. Por nefelometría se midieron los niveles séricos de las IgsG, M y A, y por ELISA se determinó la IgE total. Se encontraron 4 pacientes con deficiencia de IgG total, en el grupo de los esteroide dependientes. Mediante ELISA tipo sandwich y con anticuerpos monoclonales específicos para las sub clases de IgG se investigaron los niveles sé ricos de IgG1, 2, 3 y 4. En el 55.6% de los enfermos se encontraron una O más deficiencias de sub clases. No hubo diferencias significativas entre los grupos esteroide y no esteroide dependientes, ni entre los asmáticos alérgicos e intrínsecos, ni entre los con infección recurrente o sin ella. predominó la deficiencia de IgG1; en total el 46.7% de los pacientes tenían deficiencia aislada o combinada de IgG1, el 31.1% de IgG2, el 24.4% de IgG3 y el 17.8% de Igd4. La alta incidencia de deficiencia de sub clases podría deberse a la acción de los esteroides o a una alteración en la regulación de la síntesis de Igs producida por un defecto Inmune primario. Esta deficiencia sería la responsable del comportamiento agresivo de la enfermedad.

    We studied 45 adult asthmatic patients with difficult to care disease and who had more than five years of evolution; they suffered from elther allergic or intrinsic asthma and some had experienced recurrent respiratory tract infections. predominantly of viral etiology. Serum levels of IgA, IgG and IgM were measured by nephelometry and total lgE was determined by an Enzyme-Linked immunosorbent Assay (ELISA. Total lg

  4. Graves' disease in Albanian children.

    Science.gov (United States)

    Gjikopulli, A; Tomori, Sonila; Kollçaku, L; Hoxha, P; Grimci, Lindita; Ylli, Zamira

    2014-01-01

    Graves' disease (GD) accounts for 10-15% of thyroid disorders in patients less than 18 years of age. It is the most common cause of thyrotoxicosis in children and accounts for at least 95% of cases in children. Pediatric Treatment of Graves' disease consists of anti-thyroid drugs, radioactive iodide and thyroidectomy but the optimal treatment of GD in children is still controversial. To review treatment outcome of pediatric Graves' disease in Albania. Descriptive review of 15 children with Graves' disease, diagnosed from Jan.2007 to Dec. 2013, at the Division of Pediatric Endocrinology, Department of Pediatrics, University Hospital Centre "Mother Teresa", Albania was performed. All patients, mean age 10.56 ± 3.37 years, (range 2.02-16.09 years) were presented with goiter and increased serum FT4, mean 39.80 ± 16.02 ng/mL, (range 21.0-74.70 ng/mL), serum FT3, mean 12.98 ± 3.45 pg/mL, (range 6.90 -17.90 pg/mL) and suppressed TSH levels, mean 0.02 ± 0.01 mUI/L, (range 0.01-0.05 mUI/L). Anti TSH Receptor were positive in 100% of patients mean value 6.51 ± 3.61 UI/mL (range 1.63 - 14.10 UI/mL). Anti-thyroglobulin and Anti-TPO antibodies were positive in 60% and 46.6% respectively. Clinical course of 15 patients after treatment with anti-thyroid drugs mainly MMI for 3.19 ± 1.48 (range 0.60 - 6.20) years is as follows: seven (46.66%) underwent remission, five out of seven (71.41%) who underwent remission, relapsed. Three of them (20%) were treated with I(131), and two (13.3%) underwent to total thyroidectomy. MMI was the most common first line therapy in the presented patients with Graves' disease. Remission rate was 46.66% after an average 1.48 ± 0.71 years (range 0.60 - 2.70 years) of treatment with anti-thyroid drugs. Remission period was 2.70 ± 0.36 years (2.1 - 3.1 years) Relapse occurred in 71.41% of patient. I(131) and thyroidectomy were used as second line therapy in the present study.

  5. The relationship between the severity of asthma and comorbidites with anxiety and depressive disorders Relação entre a gravidade da asma e comorbidade com transtornos de ansiedade e depressão

    Directory of Open Access Journals (Sweden)

    Alexandre M Valença

    2006-09-01

    utilização do Mini-International Neuropsychiatric Interview 4.4 Version. RESULTADOS: Vinte e sete (43,5% pacientes preencheram os critérios para ao menos um diagnóstico psiquiátrico. Os diagnósticos mais freqüentes foram depressão maior (24,0%, transtorno de ansiedade generalizada (20,9% e transtornos do espectro pânico/agorafobia (17,7%. Não encontramos diferenças significativas na prevalência de transtornos de ansiedade e depressão entre os grupos com asma leve/moderada e com asma grave. Apesar da alta freqüência de depressão e transtornos de ansiedade, apenas 4 (6,5% pacientes estavam em tratamento psiquiátrico e 13 (20,9% estavam usando benzodiazepínicos. Doze dos 15 (80,0% pacientes em uso de medicação psicotrópica não estavam em tratamento psiquiátrico no momento do estudo. CONCLUSÃO: Nossos resultados demonstram a elevada comorbidade de transtornos de ansiedade e depressão em pacientes asmáticos, independente da gravidade da asma.

  6. Asma bronquial: factores de riesgo de las crisis y factores preventivos Bronchial asthma: risk factors of crises and preventive factors

    Directory of Open Access Journals (Sweden)

    Anselmo Abdo Rodríguez

    2007-09-01

    Full Text Available En los últimos años, y con motivo de los avances que se realizan en el campo de la investigación del asma bronquial, los conceptos en su prevención han ido cambiando entre los especialistas que lo tratan. Este trabajo tiene como objetivo llevar el conocimiento básico necesario a los profesionales de la medicina, para que a cada paciente asmático, atendido por primera vez, se le determinen los alergenos desencadenantes, los factores agravantes y socioculturales que le rodean y que pueden estar afectándolo. Se aborda la sensibilización a alergenos desde la etapa embrionaria y lactancia en el niño atópico, cuándo debemos considerar a un niño con alto riesgo alérgico, los factores de riesgo más importantes, con experiencias prácticas en el Hospital Universitario “Calixto García”, y las recomendaciones para la prevención de las enfermedades alérgicas en lactantes e infantes de alto riesgo alérgico.En recent years and advances in research field of bronchial asthma, features in its prevention has been changing among specialists treating it. Aim of this paper is to transmit the basic and necessary knowledge to medicine professionals for that in each asthmatic patient treated for the first time, the triggering allergens, aggravating factors, and the surrounded sociocultural ones, affecting him be determined. Authors approach sensitivity to allergens from embryonic stage and the lactation in atopic child, when we must to consider the case of an allergic and in high risk child, the more significant risk factors, with practical experiences in “Calixto García” University Hospital, and recommendations for preventions of allergic diseases in infants and breast-fed child in high risk of allergy.

  7. Substâncias de origem vegetal potencialmente úteis na terapia da asma

    Directory of Open Access Journals (Sweden)

    Maria Fernanda P. Corrêa

    Full Text Available A asma é uma doença inflamatória crônica, que representa um problema de saúde pública com altos números de óbitos e elevado impacto socioeconômico. A patologia é caracterizada pela fase imediata, mediada pela resposta aguda de células inflamatórias, e a tardia, que é responsável pela resposta com envolvimento de células específicas do sistema imunológico. Atualmente, os principais tipos de fármacos utilizados no tratamento da asma são os broncodilatadores e agentes antiinflamatórios, que aliviam os sintomas de broncoespasmo e diminuem a inflamação das vias aéreas. Entretanto, terapias com esses medicamentos não são totalmente eficazes e provocam efeitos adversos. A escassez de fármacos seguros e o baixo acesso da população carente aos tratamentos utilizados estimulam a busca de novas substâncias potencialmente úteis no tratamento da asma. Produtos naturais de origem vegetal representam um grande potencial farmacológico contra asma, uma vez que podem fornecer moléculas diversas com mecanismos específicos para tratamento e controle da patologia. A busca por terapias mais eficientes e específicas para o processo asmático mostra que a procura nos produtos naturais é promissora e possui um papel importante para a descoberta de novas terapias contra a asma.

  8. Pneumomediastino espontâneo: Asma Spontaneous pneumomediastinum: Asthma

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    Marcelo Cunha Fatureto

    2008-06-01

    Full Text Available Pneumomediastino é definido como a presença de ar livre no mediastino, sendo que o espontâneo ocorre na ausência de enfermidades ou factores precipitantes. É raro em adultos, sendo mais frequente em recém-nascidos. Contudo, ocorre mais em adultos jovens, sendo 8:1 a relação entre homens e mulheres. Constitui achado raro na asma, representando 1% dos casos. Os sintomas mais frequentes são dor torácica e dispneia. O diagnóstico é feito com exames de imagem, como radiografia e tomografia computadorizada de tórax. O tratamento de escolha é conservador, não operatório, com prognóstico favorável na maioria dos casos. O nosso propósito é relatar um caso desta patologia em jovem atendido em nosso serviço com quadro de dor torácica e dispneia, sendo submetido a exames complementares e feito o diagnóstico de pneumomediastino espontâneo. O doente foi submetido a tratamento conservador com excelente evolução clínica. No momento encontra-se assintomático, em acompanhamento ambulatorial.Pneumomediastinum is defined as the presence of free air in the mediastinum, and the spontaneous occurs in the absence of diseases or precipitating factors. It is rare in adults, and it is more frequent in newborns. However, it occurs more in young adults, with an 8:1 relationship between men and women. It constitutes a rare finding in asthma, representing 1% of the cases. More frequent symptoms are chest pain and dyspnea. Diagnosis is made with image examinations, such as radiography and chest computed tomography. Treatment of choice is conservative, nonoperative, with a favourable prognosis in the majority of the cases. Our aim is to report a case of this pathology in a young adult seen in our service with chest pain and dyspnea. He underwent complementary examinations and the diagnosis was spontaneous pneumo-mediastinum. This patient was submitted to a conservative treatment with excellent clinical evolution. At the moment, he is asymptomatic and

  9. Gestión del riesgo de asma por haba de soja: monitorización y vigilancia Risk management of soybean-related asthma: monitoring and surveillance

    Directory of Open Access Journals (Sweden)

    Joan R. Villalbí

    2011-12-01

    Full Text Available Objetivos: Las emisiones de alérgeno durante la descarga de haba de soja en el puerto de Barcelona han sido causa de asma epidémica. Este trabajo describe las acciones de vigilancia y control de los servicios de salud pública. Métodos: Los datos se extraen del dispositivo de control durante el periodo de 1999 a 2009, detallando el sistema de vigilancia de emisiones y concentraciones ambientales de alérgeno (para las que se han fijado empíricamente niveles guía, y de salud. Resultados: De los 95 estudios de emisión, cuatro superaron los valores de alarma, con probables causas en los filtros. Las concentraciones ambientales medias son bajas, pero superaron el nivel de alarma 13 días; se relacionan con meteorología adversa e incidencias en las instalaciones. No se detectaron efectos en los pacientes del panel de vigilancia, ni días de asma epidémica. Conclusiones: El sistema detecta incidencias y ha mostrado su utilidad para preservar la salud pública.Objectives: Allergen emissions during soybean unloading operations in the Barcelona harbor have caused asthma epidemics. The present article aimed to describe the surveillance and control measures carried out by the public health services. Methods: Data were extracted from control systems from 1999 to 2009, with description of the surveillance schemes for allergen emissions, environmental concentrations (with defined reference levels and for health. Results: Of 95 studies of plant emission, four were above the reference levels, and filters were found to be the most likely cause. Mean environmental concentrations were low but were above the reference levels on 13 days; these levels were related to adverse meteorological conditions and incidents in the plants. No health effects were detected in the panel of patients nor epidemic asthma days. Conclusions: The system detects incidents and has shown its usefulness in protecting public health.

  10. Antiphospholipid antibody syndrome complicated by Grave's disease.

    Science.gov (United States)

    Takahashi, Ayumi; Tamura, Atsushi; Ishikawa, Osamu

    2002-12-01

    The report describes a woman with primary antiphospholipid antibody syndrome complicated with Grave's disease. Developing symptoms included a small cutaneous nodule on her finger and subsequently ecchymotic purpura on the cheeks, ears, buttocks and lower legs. Histological examinations showed thrombosed vessels in the dermis without or with hemorrhage, respectively. Laboratory investigation revealed positive lupus anticoagulant and immunogenic hyperthyroidism due to Grave's disease. There is a close relationship between the cutaneous manifestation of antiphospholipid antibody syndrome and the activities of Grave's disease and a possible link of antiphospholipid antibody syndrome with Grave's disease was suggested both by the etiology of the disease as well as the disease activity.

  11. Preeclampsia grave: características y consecuencias

    Directory of Open Access Journals (Sweden)

    Arturo Pérez de Villa Amil Álvarez

    2015-07-01

    Full Text Available Fundamento: la preeclampsia es un trastorno hipertensivo del embarazo y es una de las principales causas de morbimortalidad perinatal y materna. Objetivo: identificar los factores maternos, terapéuticos, y daños asociados a la preeclampsia grave en gestantes. Método: estudio de serie de casos, que incluyó 69 pacientes diagnosticadas con preeclampsia grave en el período del 1ro de enero de 2012 al 31 de diciembre de 2013, atendidas en el Hospital General Universitario Dr. Gustavo Aldereguía Lima. Se clasificaron en dos grupos correspondiendo ambos a los criterios de preeclampsia grave con y sin asociación de factores agravantes. Se evaluaron variables relacionadas a: características maternas, características de atención médica, características neonatales y fetales. Se aplicó un formulario confeccionado según los datos obtenidos de las historias clínicas, acorde a la Clasificación Internacional de Enfermedades Décima Revisión. Las comparaciones entre grupos se efectuaron por el estadístico X2 aceptándose como significativo una p<0,05. Resultados: la frecuencia de preeclampsia grave fue de 0,8x100 partos. La mayor frecuencia correspondió al rango de edad de 31-35 años. La eclampsia se observó en 0,91x1000 partos. El daño materno ascendió a 30,4 %. El sulfato de magnesio se utilizó como profilaxis en el 89 % de los casos. La frecuencia de eclampsia en las que no se usó fue del 50 %, mientras que en las que se usó fue de solo 6,4 %. La cesárea se realizó en el 85,5 % de las pacientes. El daño neonatal se asoció al 52,3 %. La mortalidad fetal tardía fue de 4,6x100 nacimientos. En las diferencias intergrupos se observaron divergencias significativas respecto al daño neonatal. Conclusión: es evidente la alta asociación de restricción del crecimiento intrauterino con la prematuridad inducida, alto índice de cesárea primitiva y el elevado daño materno, neonatal y fetal. El uso del sulfato de magnesio impresiona con

  12. Comportamiento del asma bronquial en adolescentes tratados en el Policlínico Universitario "Ana Betancourt" Course of bronchial asthma in adolescents seen in "Ana Betancourt" University Polyclinic

    Directory of Open Access Journals (Sweden)

    Tatiana de la Vega Pazitková

    2010-03-01

    Full Text Available Introducción: el asma infantil representa una entidad que aún no ha logrado ser bien definida y delimitada, lo que establece variadas interpretaciones de su epidemiología, diagnóstico y, consecuentemente de su tratamiento. Objetivos: estimar la prevalencia global de asma en adolescentes tratados en consultorios médicos de familia del Policlínico Universitario "Ana Betancourt". Métodos: se realizó un estudio descriptivo, de corte transversal, que incluyó a 81 adolescentes de ambos sexos con edades entre 11 y 18 años, pertenecientes a dos consultorios médicos de familia del Grupo Básico de Trabajo No. 2, del Policlínico Universitario "Ana Betancourt", del municipio Playa, en el período comprendido entre enero de 2006 y enero de 2007. Como herramienta de trabajo se utilizó el cuestionario: The International Study of Asthma and Allergies in Childhood, instrumento validado internacionalmente. Resultados: la cifra total de asmáticos ascendió a 52 adolescentes con un discreto predominio del sexo masculino y de los casos ligeros de la enfermedad, para una prevalencia global de 64,1 %. Se encontró un subregistro de 20,9 %. Conclusiones: en ambos consultorios se constata una elevada prevalencia de asma bronquial en la población de adolescentes con mayor afectación en los varones. Los pacientes exhiben mayoritariamente las formas ligeras de la enfermedad. Se encuentra un importante subregistro para el asma bronquial en los adolescentes tratados en el Policlínico Universitario "Ana Betancourt"Introduction: the bronchial asthma is a even defined entity establishing some interpretations of its epidemiology, diagnosis and consequently of its treatment. Objectives: to estimate the global prevalence of asthma in adolescents seen in family medical consulting rooms from "Ana Betancourt" University Polyclinic. Methods: a descriptive, cross-sectional study was conducted including 81 adolescents of both sexes aged between 11 and 18 from family

  13. Hubungan Keteraturan Penggunaan Kortikosteroid Inhalasi dengan Tingkat Kontrol Asma Pasien Berdasarkan ACT di Poliklinik Paru RSUP Dr. M. Djamil Padang

    Directory of Open Access Journals (Sweden)

    Wulan Prisilla Prisilla

    2016-01-01

    Full Text Available AbstrakAsma merupakan penyakit yang didasari oleh reaksi inflamasi pada saluran napas yang dapat dicegah dengan kortikosteroid inhalasi. Asma sukar disembuhkan, sehingga tujuan penatalaksanaan asma adalah asma terkontrol. Penilaian tingkat kontrol asma dapat dilakukan dengan menggunakan kuesioner Asthma Control Test  (ACT yang bersifat subjektif tetapi validitasnya telah diuji. Tujuan penelitian ini adalah menentukan hubungan keteraturan penggunaan kortikosteroid inhalasi dengan tingkat kontrol asma pasien berdasarkan ACT di Poliklinik Paru RSUP Dr. M. Djamil Padang. Penelitian cross sectional analytic ini telah dilakukan dari September hingga Desember 2013. Populasi adalah pasien berusia ≥14 tahun yang didiagnosis asma oleh dokter. Jumlah subjek penelitian sebanyak 96 orang. Data yang diperoleh diolah dan dianalisis menggunakan uji Kolmogorov-Smirnov. Insiden terbanyak asma berada pada kelompok usia lanjut (60,4%. Sebagian besar pasien tidak teratur menggunakan kortikosteroid inhalasi (63,5% dan pasien dengan asma tidak terkontrol memiliki proporsi tertinggi (59,4% . Analisis statistik menunjukkan bahwa terdapat hubungan yang bermakna antara keteraturan penggunaan kortikosteroid inhalasi dengan tingkat kontrol asma pasien berdasarkan ACT di Poliklinik Paru RSUP Dr. M. Djamil (p=0,002.Kata kunci: kortikosteroid inhalasi, ACT, tingkat control asma AbstractAsthma is a disease caused by an inflammatory reaction in the patient airways that can be prevented with inhaled corticosteroids. It is known that there is no cure for asthma, so the goal of asthma management is to obtain controlled asthma. The level of asthma control can be assessed by  using Asthma Control Test  (ACT questionnaire, this method is subjective but its validity has been tested. The objective of this study  was to determine the association between regularity of inhaled corticosteroids application and patient’s level of asthma control based on ACT in the Lung Clinic of Dr

  14. Reacciones adversas graves y mortales a los antimicrobianos. Sistema Cubano de Farmacovigilancia, 2003-2012

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    Ismary Alfonso Orta

    Full Text Available Introducción: las reacciones adversas a los antimicrobianos ocasionan más de 142 000 visitas a las salas de urgencias hospitalarias por año en los Estados Unidos. En Cuba han ocupado el primer lugar en el reporte, por ejemplo, en el año 2008 representaron el 31,4 % del total de las reacciones adversas graves y el 25 % de las reacciones adversas mortales. Objetivo: caracterizar las reacciones adversas graves y mortales a los antimicrobianos notificadas a la Unidad Nacional Coordinadora de Farmacovigilancia, durante el periodo 2003-2012. Métodos: se realizó un estudio de farmacovigilancia, observacional, descriptivo y transversal, utilizando la base de datos nacional de farmacovigilancia durante el periodo 2003-2012. Se trabajó con el total de reportes de reacciones adversas graves y mortales a los antimicrobianos. Las reacciones adversas se clasificaron según tipo de reacción, sistema de órgano afectado, imputabilidad y frecuencia. Se identificaron los principales antimicrobianos sospechosos y se estudiaron los pacientes que presentaron reacciones adversas según sexo y edad. Resultados: se detectaron 631 sospechas de reacciones adversas graves y mortales a los antimicrobianos, de ellas fueron 550 graves y 81 mortales. Predominaron el sexo femenino con 60,1 % y 405 adultos. Las reacciones adversas comprometieron los sistemas: general (30,4 %, respiratorio (25,2 % y cardiovascular (14,9 %. El shock anafiláctico fue la reacción más reportada y la penicilina el fármaco más relacionado con esta. El 73,5 % fueron probables y el 58,9 % ocasionales. Conclusiones: las reacciones adversas graves y mortales predominaron en el sexo femenino y en los adultos. La penicilina fue el fármaco más relacionado. Las reacciones adversas probables y ocasionales fueron la mayoría en el estudio.

  15. Epidemiology and prevention of Graves' ophthalmopathy

    NARCIS (Netherlands)

    Wiersinga, Wilmar M.; Bartalena, Luigi

    2002-01-01

    Graves' ophthalmopathy is clinically relevant in approximately 50% of patients with Graves' disease, severe forms affecting 3%-5% of patients. Two age peaks of incidence are observed in the fifth and seventh decades of life, with slight differences between women and men. The disease is more frequent

  16. PREGO (presentation of Graves' orbitopathy) study

    DEFF Research Database (Denmark)

    Perros, Petros; Žarković, Miloš; Azzolini, Claudio

    2015-01-01

    BACKGROUND/AIMS: The epidemiology of Graves' orbitopathy (GO) may be changing. The aim of the study was to identify trends in presentation of GO to tertiary centres and initial management over time. METHODS: Prospective observational study of European Group On Graves' Orbitopathy (EUGOGO) centres...

  17. Tratamiento del episodio agudo de asma bronquial en los servicios de urgencias pediátricos: Guía clínica práctica Treatment of the acute episode of bronchial asthma at the pediatric emergency services: Practical clinical guide

    Directory of Open Access Journals (Sweden)

    Roberto Razón Behar

    2005-12-01

    Full Text Available Por lo general, no existe una sistematización para clasificar y tratar el episodio agudo de asma bronquial ni para evaluar la evolución de los pacientes. Se realizó un estudio en 142 pacientes de 6 a 15 años de edad, que presentaron episodios agudos de asma bronquial y acudieron a los servicios de urgencias de los Hospitales Pediátricos «William Soler» y «Leonor Pérez», y del Policlínico «Federico Capdevila». A estos pacientes se les aplicó una guía clínica práctica, que incluyó la clasificación de la severidad del episodio agudo y un esquema de tratamiento, basado en la utilización de oxígeno, broncodilatadores inhalados y esteroides orales. Durante el tratamiento, los pacientes se evaluaron con periodicidad. La respuesta al tratamiento fue buena en la mayoría de los casos y el resultado final fue el egreso domiciliario. Ocho de los pacientes requirieron ingreso hospitalario por respuestas al tratamiento incompletas o pobres. La atención del episodio agudo de asma bronquial puede mejorarse con el uso de guías clínicas prácticas de diagnóstico y tratamiento.

  18. Miastenia grave ocular Severe ocular myastenia

    Directory of Open Access Journals (Sweden)

    Yaimir Estevéz Miranda

    2010-01-01

    Full Text Available La miastenia grave es una enfermedad autoinmune de la unión neuromuscular que se caracteriza por la variabilidad de la debilidad muscular, que empeora o está provocada por el ejercicio del músculo o de los grupos musculares implicados, mientras que el descanso la mejora. La primera descripción de la enfermedad data de 1672, su relación con una afección del timo no se estableció hasta 1901. La enfermedad es poco frecuente, afecta a todas las etnias por igual, y no tiene predilección geográfica. Se reporta un paciente masculino de 28 años de edad atendido en el Servicio de Oftalmología Pediátrica del Instituto Cubano de Oftalmología "Ramón Pando Ferrer" por presentar visión doble, ptosis palpebral ligera en ojo derecho que empeora con el transcurso del día. Por el interrogatorio y el cuadro clínico se sospecha de una miastenia grave, se remite al clínico y el neurólogo. En los estudios realizados de neuroimágenes, tomografía y electroencefalograma no se encontraron alteraciones. Se decide valorar el caso con el servicio de Neuroftalmología de nuestro centro y por el Instituto de Neurología y es confirmado el diagnóstico.Myasthenia gravis is an autoimmune illness of the neuromuscular joint that is characterized by the variability of the muscular weakness that worsens or caused by exercising of the muscle or the involved muscular groups; resting helps in improving the condition of the muscle. The first description of the illness dates back to 1672, but its linking to a thymus disorder was not discovered until 1901. This illness is not very frequent, affects equally to all the races, and it does not predominate in any particular geographic region. This paper presented a male patient aged 28 years who went to the Ophthalmologic Service at "Ramón Pando Ferrer" Cuban Institute of Ophthalmology because he suffered from double vision, slight palpebral ptosis in his right eye that became worse as the day went by. After the

  19. Doenças inflamatórias alérgicas das vias aéreas superiores e suas implicações na asma brônquica – A propósito de um caso clínico

    Directory of Open Access Journals (Sweden)

    Ana L. Fonseca

    2006-09-01

    Full Text Available Resumo: Os autores apresentam o caso clínico de uma doente referenciada à consulta de alergologia respiratória por “asma de difícil controlo”. A investigação clínica conduziu à identificação de patologia inflamatória crónica das vias aéreas superiores de carácter grave, como factor de agravamento da asma brônquica. Após terapêutica, que no referido caso implicou abordagem cirúrgica dos seios perinasais, houve melhoria franca do controlo da asma. A propósito do caso, é efectuada uma revisão das principais patologias inflamatórias alérgicas das vias aéreas superiores (rinite, sinusite e polipose nasal e abordadas as suas principais implicações no controlo da asma brônquica.Rev Port Pneumol 2006; XII (5: 563-580 Abstract: The authors present a case report of a patient refered to physician for “difficult-to-treat asthma”. Clinical evaluation concluded that severe chronic inflammatory upper airway disease was an asthma worsening factor. Patient demonstrated improvement in asthma control, after surgery.In the context of the clinical study, the authors present a review of the most common allergic inflammatory diseases of the upper airways (allergic rhinitis, chronic sinusitis and nasal polyposis and reflect on their impact on asthma.Rev Port Pneumol 2006; XII (5: 563-580 Palavras-chave: Asma brônquica, rinite alérgica, sinusite crónica, polipose nasal, Key-words: Asthma, allergic rhinitis, chronic sinusitis, nasal polyposis

  20. Assessment and prediction of asthma and its severity in the pediatric community Avaliação e predição da asma e sua gravidade na comunidade pediátrica

    Directory of Open Access Journals (Sweden)

    Julio Cesar R. Pereira

    1990-12-01

    Full Text Available Seventy four asthmatic children aged 7 to 11 years were examined along with controls matched by age and sex. Clinical and laboratory investigations preceded a 28-day follow-up where data about morning and evening peak expiratory flow rate (PEF, symptoms and treatment were recorded. The coefficient of variation of PEF was found to be an objective measurement of asthma severity that has statistically significant correlation with both symptoms (r s= .36 and treatment (r s= .60. Moreover, it separates mild and severe asthmatics, as confirmed by statistically significant differences (p= .008 or less in symptoms, treatment, skin allergy and airways response to exercise. Skin allergy and airways responsiveness to exercise were found to be predictors of both disease and severity. By means of logistic regression analysis it was possible to establish the probabilities for both asthma and severe asthma when children presenting and not presenting these characteristics are compared. One single positive skin test represent a probability of 88% for the development of asthma and a probability of 70% for severe disease. A PEF reduction of 10% after an exercise test implies a probability of 73% for disease and a probability of 64% for severe disease. Increases in these variables imply geometrically increased risks and their presence together have a multiplicative effect in the final risk.Foram submetidas a exames, juntamente com grupos controle segundo idade e sexo,74 crianças asmáticas, com idade de 7 a 11 anos. Exames clínicos e laboratoriais precederam um acompanhamento de 28 dias, quando foram registrados dados sobre a taxa de pico do fluxo respiratório (PEF, sintomas e tratamento. Observou-se que o coeficiente de variação do PEF é uma medida objetiva do grau de gravidade da asma, que tem uma correlação estatística significativa, tanto com os sintomas (r s = .036, quanto com o tratamento (r s = .60. Além disso, separa os asmáticos graves e leves

  1. CDC: Consejos de exfumadores: El Consejo de Jessica Sobre el Asma PSA (:30)

    Centers for Disease Control (CDC) Podcasts

    2012-03-19

    La exposición al humo de segunda mano puede provocar un ataque de asma que puede ser mortal. Este anuncio de servicio público de 30 segundos de la campaña de los CDC “Consejos de exfumadores”, muestra a Jessica, la madre de un niño pequeño que tiene ataques de asma por la exposición al humo de segunda mano. Su consejo es que las personas no sientan pena de decirles a otras que no fumen cerca de sus hijos.  Created: 3/19/2012 by Office on Smoking and Health, National Center for Chronic Disease Prevention and Health Promotion.   Date Released: 8/8/2013.

  2. Current treatment of Graves' disease

    International Nuclear Information System (INIS)

    Harada, T.; Shimaoka, K.; Mimura, T.; Ito, K.

    1987-01-01

    In this review we have described the rationale for the appropriate treatment of patients with Graves' disease. Because the etiology of this disorder remains obscure, its management remains controversial. Since antithyroid drugs and radioiodine became readily available in the early 1950s, they have been widely used for the treatment of thyrotoxicosis, and the number of cases treated surgically has markedly decreased. However, almost four decades of experience have disclosed an unexpectedly high incidence of delayed hypothyroidism after radioiodine treatment and a low remission rate after antithyroid therapy. As a result, surgery is again being advocated as the treatment of choice. The three modalities of treatment have different advantages and disadvantages, and selection of treatment is of importance. In principle, we believe that for most patients a subtotal thyroidectomy should be performed after the patient has been rendered euthyroid by antithyroid drugs. We attempt to leave a thyroid remnant of 6 to 8 gm.36 references

  3. Radioiodine treatment of Grave's disease

    International Nuclear Information System (INIS)

    Heidenreich, P.; Vogt, H.; Dorn, R.; Graf, G.; Kopp, J.

    2001-01-01

    In Germany radioiodine therapy of Grave's disease is performed in patients older than 20 years, after at least one year of unsuccessful antithyroid therapy, intolerance against antithyroid medication, recurrences after surgical interventions and small goiters. Hyperthyroidism is eliminated with an ablative dose concept (300 Gy) in more than 90% associated with rate of hypothyroidism in the outcome of also more than 90%. Adverse prognostic factors are an insufficient dose to the thyroid and/or concomitant antithyreoid medication. Radioiodine therapy in Germany must be an inpatient single time approach due to quality assurance and radiation protection reasons. The mean hospitalization is only 3-4 days with the patient being discharged at an annual dose of less than 1 mSv at 2 m distance (dose rate at discharge [de

  4. [Orbital decompression in Grave's ophtalmopathy].

    Science.gov (United States)

    Longueville, E

    2010-01-01

    Graves disease orbitopathy is a complex progressive inflammatory disease. Medical treatment remains in all cases the proposed treatment of choice. Surgical treatment by bone decompression can be considered as an emergency mainly in cases of optic neuropathy or ocular hypertension not being controlled medically or in post-traumatic exophthalmos stage. Emergency bone decompression eliminates compression or stretching of the optic nerve allowing visual recovery. The uncontrolled ocular hypertension will benefit from decompression. The normalization of intraocular pressure may be obtained by this surgery or if needed by the use of postoperative antiglaucoma drops or even filtration surgery. In all operated cases, the IOP was normalized with an average decrease of 7.71 mmHg and a cessation of eye drops in 3/7 cases. Regarding sequelae, our therapeutic strategy involves consecutively surgery of the orbit, extraocular muscles and eyelids. The orbital expansion gives excellent results on the cosmetic level and facilitates the implementation of subsequent actions.

  5. Hypofractionated radiotherapy for Graves' orbitopathy

    International Nuclear Information System (INIS)

    Heyd, R.; Herkstroeter, M.; Martin, T.; Zamboglou, N.; Strassmann, G.

    2001-01-01

    Background: Radiotherapy (RT) has been proven effective in the management of Graves' orbitopathy in numerous studies. Most commonly is the use of conventional fractionated RT and the value of hypofractionated irradiation has not been investigated. Materials and methods: The results in 33 euthyroid cases who underwent RT with a total dose of 21.0 Gy given in three weekly fractions of 3.0 Gy are retrospectively analyzed. The duration of symptoms ranged from 1-84 months and all of the cases had treatment failure after previous administration of corticosteroids. After a mean follow-up period of 33.6 months the overall results were assessed according to the criteria by Donaldson et al. and for evaluation of the clinical outcome a classification with the main criteria being eye-lid changes, exophthalmos, myopathy and eye nerve involvement was used. Results: At follow-up, the overall response to RT was 84.8% (28/33 cases). The analysis with the clinical classification demonstrated that in 19/33 (57.6%) cases occurred a decrease of eye lid changes and exophthalmos and 12/33 (36.4%) had a relief of myopathy. 2/33 cases (6.0%) developed an eye nerve compression causing the necessity of surgical decompression. 3/33 cases (9.0%) had a progression of at least of one of the single criteria of the score and therefore they were classified as non-responders. Conclusions: Hypofractionated RT has been proven effective for treatment of severe cases of Graves' orbitopathy in cases with a prolongated duration of symptoms. The comparison with literature data demonstrate that the results after hypofractionated RT are comparable to those obtained after conventional fractionated RT. (orig.)

  6. AsMA Medical Guidelines for Air Travel: In-Flight Medical Care.

    Science.gov (United States)

    Thibeault, Claude; Evans, Anthony D; Pettyjohn, Frank S; Alves, Paulo M

    2015-06-01

    Medical Guidelines for Airline Travel provide information that enables healthcare providers to properly advise patients who plan to travel by air. All airlines are required to provide first aid training for cabin crew, and the crew are responsible for managing any in-flight medical events. There are also regulatory requirements for the carriage of first aid and medical kits. AsMA has developed recommendations for first aid kits, emergency medical kits, and universal precaution kits.

  7. Estudio prospectivo de la cefalea en pacientes con hemopatías malignas

    OpenAIRE

    Marín Lahoz, Juan

    2013-01-01

    Objetivo: describir las cefaleas en pacientes ingresados con neoplasias hematológicas, identificar los factores asociados a cefaleas secundarias graves. Estudio observacional prospectivo. Se incluyen 30 casos de cefalea correspondientes a 23 pacientes. Ocho cefaleas son primarias y 22 secundarias. Diez de estas, son secundarias a patología grave o potencialmente grave: encefalopatía hipertensiva, neoplasia intracraneal, hemorragia intracraneal, infección cefálica, trombosis venosa, fiebre tum...

  8. Broncoespasmo induzido pelo exercício em crianças e adolescentes com diagnóstico de asma Exercise-induced bronchospasm in children and adolescents with a diagnosis of asthma

    Directory of Open Access Journals (Sweden)

    Vitor E. Cassol

    2004-04-01

    Full Text Available INTRODUÇÃO: A broncoconstrição temporária após o exercício físico tem elevada prevalência em crianças e adolescentes asmáticos. OBJETIVO: Determinar a freqüência e gravidade do broncoespasmo induzido pelo exercício em crianças e adolescentes, com diagnóstico clínico de asma leve, moderada e grave. MÉTODO: Foi realizado um estudo descritivo, tipo transversal, não controlado. A amostra constituiu-se de 40 indivíduos asmáticos, de ambos os sexos, com idade entre 7 e 18 anos, que não utilizavam regularmente medicação anti-inflamatória. Foi realizado teste padronizado de provocação brônquica com exercício de corrida em esteira rolante. A espirometria foi padronizada em seis manobras expiratórias, realizadas antes e aos 1, 5, 10, 15, 20 e 30 minutos após o término do exercício, sendo escolhida a de maior valor. O volume expiratório forçado no primeiro segundo (VEF1 foi utilizado para o diagnóstico e classificação da gravidade do broncoespasmo. Os pacientes asmáticos apresentavam condições clínicas e espirométricas adequadas para os testes (VEF1 > 70% do valor previsto. Foi utilizada como critério de positividade para o broncoespasmo induzido pelo exercício queda >10% em relação ao VEF1 prévio ao exercício. RESULTADOS: Vinte e seis (65% pacientes desenvolveram broncoespasmo após o exercício. Dos pacientes com asma leve 44%, e dos com asma moderada e grave, 100% desenvolveram broncoespasmo. Houve associação significativa entre a freqüência do broncoespasmo induzido pelo exercício e a gravidade da asma (pINTRODUCTION: In asthmatic children and adolescents a high incidence of temporary bronchospasm is perceived after physical exertion. OBJECTIVE: To investigate incidence and severity of exercise-induced bronchospasm in children and adolescents with a clinical diagnosis of mild, moderate or severe asthma. METHOD: A descriptive, cross-sectional, not controlled study was carried out. The sample

  9. Resolution of Graves' disease after renal transplantation.

    Science.gov (United States)

    Lee, Yvonne; Butani, Lavjay; Glaser, Nicole; Nguyen, Stephanie

    2016-06-01

    We report a case of an adolescent boy with Down's syndrome and ESRD on hemodialysis who developed mild Graves' disease that was not amenable to radioablation, surgery, or ATDs. After 14 months of observation without resolution of Graves' disease, he successfully received a DDRT with a steroid minimization protocol. Thymoglobulin and a three-day course of steroids were used for induction and he was started on tacrolimus, MMF, and pravastatin for maintenance transplant immunosuppression. One month after transplantation, all biochemical markers and antibody profiling for Graves' disease had resolved and remain normal one yr later. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  10. Nodular Graves' disease with medullary thyroid cancer.

    Science.gov (United States)

    Khan, Shoukat Hussain; Rather, Tanveer Ahmed; Makhdoomi, Rumana; Malik, Dharmender

    2015-01-01

    Co-existence of thyroid nodules with Graves' disease has been reported in various studies. 10-15% of such nodules harbor thyroid cancer with papillary thyroid cancer being the commonest. Medullary thyroid cancer (MTC) in nodules associated with Graves' disease is rare. On literature survey, we came across 11 such cases reported so far. We report a 62-year-old female with Graves' disease who also had a thyroid nodule that on fine-needle aspiration cytology and the subsequent postthyroidectomy histopathological examination was reported to be MTC.

  11. Ventilação mecânica na crise de asma aguda Mechanical ventilation in acute asthma crisis

    Directory of Open Access Journals (Sweden)

    Carmen Sílvia Valente Barbas

    2007-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Em 2000, foi publicado o II Consenso Brasileiro de Ventilação Mecânica. Desde então, o conhecimento na área da ventilação mecânica avançou rapidamente, com a publicação de inúmeros estudos clínicos que acrescentaram informações importantes para o manuseio de pacientes críticos em ventilação artificial. Além disso, a expansão do conceito de Medicina Baseada em Evidências (MBE determinou a hierarquização das recomendações clínicas, segundo o rigor metodológico dos estudos que as embasaram. Essa abordagem explícita vem ampliando a compreensão e a aplicação das recomendações clínicas. Por esses motivos, a AMIB - Associação de Medicina Intensiva Brasileira - e a SBPT - Sociedade Brasileira de Pneumologia e Tisiologia - julgaram conveniente a atualização das recomendações descritas no Consenso anterior. Dentre os tópicos selecionados a Ventilação Mecânica na Crise de Asma foi um dos temas propostos. O objetivo deste estudo foi descrever os pontos mais importantes relacionados à ventilação mecânica durante a crise de asma e sugerir as principais abordagens terapêuticas. MÉTODO: Objetivou-se chegar a um documento suficientemente sintético, que refletisse a melhor evidência disponível na literatura. A revisão bibliográfica baseou-se na busca de estudos através de palavras-chave e em sua gradação conforme níveis de evidência. As palavras-chave utilizadas para a busca foram: Ventilação mecânica na asma: asthma and mechanical ventilation. RESULTADOS: São apresentadas recomendações quanto aos modos ventilatórios e aos parâmetros a serem aplicados quando do ajuste do ventilador, além da monitoração recomendada. Apresentam-se ainda, técnicas alternativas que possam ser utilizadas. CONCLUSÕES: Estratégias protetoras de ventilação mecânica são recomendadas durante a ventilação mecânica de paciente asmático grave.BACKGROUND AND OBJECTIVES: The II Brazilian

  12. Tratamiento quirúrgico del estrabismo en la enfermedad de graves

    OpenAIRE

    Dr. C. Iván Villaseca

    2010-01-01

    El estrabismo en la Oftalmopatía (Orbitopatía) de Graves se origina en la fibrosis post inflamatoria de uno o varios músculos, en uno o ambos ojos. Esto provoca un desalineamiento de los ejes visuales con diplopia que puede llegar a ser invalidante. Los músculos más frecuentemente comprometidos son los Rectos Inferiores y Medios. Algunos pacientes compensan su diplopia con posiciones anómalas de la cabeza. La cirugía se plantea en la etapa inactiva de la inflamación orbitaria, con ángulos est...

  13. Asma induzida pelo exercício: aspectos atuais e recomendações Asma inducido por el ejercicio: aspectos actuales y recomendaciones Exercise-induced asthma: current aspects and recommendations

    Directory of Open Access Journals (Sweden)

    Orlando Laitano

    2007-02-01

    Full Text Available OBJETIVO: Descrever os mecanismos da asma induzida pelo exercício (AIE, bem como os efeitos de diferentes tipos de treinamento físico na função pulmonar e nas capacidades aeróbia e anaeróbia. Destaca-se a importância de um diagnóstico correto mediante o teste de exercício e, no manejo, o uso de drogas beta-adrenérgicas e anticolinérgicas. FONTE DOS DADOS: Os artigos foram criteriosamente escolhidos utilizando as bases de dados PubMed e Scielo pelo ano de publicação e dando preferência a ensaios clínicos randomizados, com critérios de seleção da amostra bem definidos. SÍNTESE DOS DADOS: Os mecanismos para explicar a AIE permanecem sem conclusão, mas parece haver uma interação fisiológica entre as hipóteses aqui apresentadas. O uso de medicamentos e as freqüentes crises durante o exercício aparecem como fatores limitantes para a prática de exercícios físicos, conduzindo para um estilo de vida sedentário. CONCLUSÃO: Deve-se incentivar a prática de exercícios devidamente prescritos e minimizar as restrições aos sujeitos com AIE.OBJETIVO: Describir los mecanismos del asma inducido por el ejercicio (AIE, así como los efectos de diferentes tipos de entrenamiento físico sobre la función pulmonar y las capacidades aeróbica y anaeróbica. Se destaca la importancia de un diagnóstico correcto mediante el test de ejercicio y el manejo o uso de drogas beta-adrenérgicas y anticolinérgicas. FUENTES: Los artículos fueron cuidadosamente escogidos utilizando las bases de dados de PubMed y Scielo por el año de publicación, dando preferencia a ensayos clínicos randomizados, con criterios de selección de muestra bien definidos. SÍNTESES DE DATOS: Los mecanismos para explicar la AIE permanecen sin conclusión, pero parece haber una interacción fisiológica entre las hipótesis aquí presentadas. El uso de medicamentos y las frecuentes crisis durante el ejercicio aparecen como factores limitantes para la práctica de

  14. Broncodilatadores en el tratamiento del asma crónica

    Directory of Open Access Journals (Sweden)

    Rogelio Alvarez Sintes

    1995-08-01

    Full Text Available Se realiza una revisión de la literatura médica al respecto y se señalan las pautas actuales del tratamiento broncodilatador intercrítico del paciente asmático, con el objetivo de facilitar al personal de atención ambulatoria los elementos necesarios en la atención de nuestros pacientes.

  15. Graves' disease: thyroid function and immunologic activity

    International Nuclear Information System (INIS)

    Gossage, A.A.R.; Crawley, J.C.W.; Copping, S.; Hinge, D.; Himsworth, R.L.

    1982-01-01

    Patients with Graves' disease were studied for two years during and after a twelve-month course of treatment. Disease activity was determined by repeated measurements of thyroidal uptake of [ 9 -9μTc]pertechnetate during tri-iodothyronine administration. These in-vivo measurements of thyroid stimulation were compared with the results of in-vitro assays of Graves, immunoglobulin (TSH binding inhibitory activity - TBIA). There was no correlation between the thyroid uptake and TBIA on diagnosis. Pertechnetate uptake and TBIA both declined during the twelve months of antithyroid therapy. TBIA was detectable in sera from 19 of the 27 patients at diagnosis; in 11 of these 19 patients there was a good correlation (p<0.05) throughout the course of their disease between the laboratory assay of the Graves, immunoglobulin and the thyroid uptake. Probability of recurrence can be assessed but sustained remission of Graves' disease after treatment cannot be predicted from either measurement alone or in combination

  16. Terapia de resgate com amiodarona em crianças com grave disfunção ventricular esquerda causada por veneno de escorpião Terapia de rescate con amiodarona en niños con severa disfunción ventricular izquierda ocasionada por veneno de escorpión Antiadrenergic rescue therapy with amiodarone in children with severe left ventricular dysfunction secondary to scorpion envenomation

    Directory of Open Access Journals (Sweden)

    Justo J. Santiago

    2010-01-01

    Full Text Available FUNDAMENTO: As crianças picadas por escorpião, pressintam ativação maciça do sistema nervoso simpática com vários graus de disfunção sistólica ventricular esquerda. OBJETIVO: Testar um protocolo de resgate em crianças com grave disfunção ventricular esquerda causada por picada de escorpião. Métodos: Quatro crianças após serem picadas por escorpião foram submetidas a: Encubação endotraqueal e suporte respiratório, eletrocardiograma, radiografia de tórax, ecocardiograma e determinação sérica da norepinefrina e troponina I. As análises foram repetidas após 12, 24 e 48 horas. As seguintes medicações intravenosas foram administradas: dobutamina 4-6 μg/kg/min; amiodarona 3 mg/kg durante duas horas, com dose de manutenção de 5 mg/kg/dia; e furosemida 0,5 mg/kg. Amiodarona, dobutamina e furosemida foram administradas durante as primeiras 48 horas. Bloqueadores beta-adrenérgicos e inibidores da enzima conversora da angiotensina foram administrados até 48 após a internação, uma vez que o estado clínico havia melhorado e a fração de ejeção ventricular esquerda encontrava-se acima de 0,35%. RESULTADOS: Na admissão, a dosagem da norepinefrina foi 1.727,50± 794,96 pg/ml, a de troponina I 24,53 ± 14,09 ng/ml e a fração de ejeção do ventrículo esquerdo foi 0,20 ± 0,056. Após 12 horas, os níveis séricos de norepinefrina e de troponina I diminuíram para a metade dos valores iniciais e a fração de ejeção aumentou para 0,32 ± 0,059. Durante as 24 e 48 horas subseqüentes, a fração de ejeção elevou-se para 0,46 ± 0,045 (pFUNDAMENTO: Los niños con picaduras de escorpión sufren activación masiva del sistema nervioso simpático con varios grados de disfunción sistólica ventricular izquierda. OBJETIVO: Probar un protocolo de rescate en niños con disfunción ventricular severa izquierda ocasionada por picadura de escorpión. MÉTODOS: Cuatro niños tras un escorpión picarlas se sometieron a: incubaci

  17. Postoperative hypocalcemia after thyroidectomy for Graves' disease.

    Science.gov (United States)

    Pesce, Catherine E; Shiue, Zita; Tsai, Hua-Ling; Umbricht, Christopher B; Tufano, Ralph P; Dackiw, Alan P B; Kowalski, Jeanne; Zeiger, Martha A

    2010-11-01

    It is believed that patients who undergo thyroidectomy for Graves' disease are more likely to experience postoperative hypocalcemia than patients undergoing total thyroidectomy for other indications. However, no study has directly compared these two groups of patients. The aim of this study was to determine whether there was an increased incidence or severity of postoperative hypocalcemia in patients who underwent thyroidectomy for Graves' disease. An institutional review board-approved database was created of all patients who underwent thyroidectomy from 1998 to 2009 at the Johns Hopkins Hospital. There were a total of 68 patients with Graves' disease who underwent surgery. Fifty-five patients who underwent total thyroidectomy were randomly selected and served as control subjects. An analysis was conducted that examined potential covariates for postoperative hypocalcemia, including age, gender, ethnicity, preoperative alkaline phosphatase level, size of goiter, whether parathyroid tissue or glands were present in the specimen, and the reason the patient underwent surgery. Specific outcomes examined were calcium levels on postoperative day 1, whether or not patients experienced symptoms of hypocalcemia, whether or not Rocaltrol was required, the number of calcium tablets prescribed upon discharge, whether or not postoperative tetany occurred, and calcium levels 1 month after discharge. Each outcome was analyzed using a logistic regression. Graves' disease patients had a significantly (p-value Graves' disease and no patient in the control group were readmitted with tetany (p = 0.033). There was a trend, though not significant, toward patients with Graves' disease having a higher prevalence of hypocalcemia the day after thyroidectomy and 1 month later. Patients with Graves' disease are more likely to require increased dosages of calcium as well as experience tetany postoperatively than patients undergoing total thyroidectomy for other indications. This suggests that

  18. [Thyroid cancer in patients with Grave's Disease].

    Science.gov (United States)

    Mssrouri, R; Benamr, S; Essadel, A; Mdaghri, J; Mohammadine, El H; Lahlou, M-K; Taghy, A; Belmahi, A; Chad, B

    2008-01-01

    To evaluate the incidence of thyroid carcinoma in patients operated on for Graves' disease, to identify criteria which may predict malignancy, and to develop a practical approach to determine the extensiveness of thyroidectomy. Retrospective study of all patients who underwent thyroidectomy for Graves' disease between 1995 and 2005. 547 patients underwent subtotal thyroidectomy for Graves' disease during this period. Post-operative pathology examination revealed six cases of thyroid cancer (1.1%). All six cases had differentiated thyroid carcinoma (papillary carcinoma in 3 cases, follicular carcinoma in 2 cases and papillo-follicular carcinoma in 1 case). The indication for initial thyroidectomy was a palpable thyroid nodule in 3 cases (50%), failure of medical treatment for Grave's disease in 2 cases (33%), and signs of goiter compression in 1 case (17%). Five patients underwent re-operative total thyroidectomy. This study shows that while malignancy in Grave's disease is uncommon, the presence of thyroid nodule(s) in patients with Grave's disease may be considered as an indication for radical surgery. The most adequate radical surgery in this situation is to perform a total thyroidectomy.

  19. Cumplimiento del tratamiento para el asma bronquial por los pacientes de un área de salud

    Directory of Open Access Journals (Sweden)

    Alicia Zapata Martínez

    1998-12-01

    Full Text Available Se realizó un estudio para conocer el cumplimiento del tratamiento medicamentoso, las causas de no cumplimiento, así como los medicamentos más empleados y el grado de control de los síntomas del asma bronquial y aproximarnos a la calidad de la asistencia médica brindada a los pacientes asmáticos de un área de salud de Villa Clara. La mayoría de los pacientes no cumplían el tratamiento indicado. La causa más frecuente fue la despreocupación. Los pacientes tenían un mal control de los síntomas, y entre los medicamentos indicados predominaron los broncodilatadores inhalados para el tratamiento de los síntomas con pocos medicamentos eficaces para el tratamiento profiláctico y un pobre dominio de la técnica inhalatoria. El mal control de los síntomas no creemos se deba al incumplimiento del tratamiento, sino a deficiencias en la calidad de la prescripciónA study was conducted to know about the fulfilment of the drug therapy, the causes of the nonfulfilment, the most used drugs, the degree of control of the symptoms of bronchial asthma, and the quality of the medical assistance received by the asthmatic patients in a health area of Villa Clara. Most of the patients did not folow the indicated treatment. The most frequent cause was the lackoof preocuppation. Patients proved to have an inadequate control of the symptoms. The inhaled bronchodilators predominated among the drugs prescribed for treating the symptoms. There were a few efficient drugs for the prophylactic treatment and it was observed a poor knowledge about the inhalatory techniques. It is considered that the deficient control of the symptoms is not only due to the nonfulfilment of the treatment but to the deficiencies found in the quality of prescription

  20. ¿Hay diferencias entre la violencia grave y la violencia menos grave contra la pareja?: un análisis comparativo

    Directory of Open Access Journals (Sweden)

    Enrique Echeburúa

    2008-01-01

    Full Text Available En este estudio ex post facto se lleva a cabo una descripción de las características presentadas por 1.081 casos denunciados por violencia contra la mujer en las comisarías de la Ertzaintza del País Vasco. En primer lugar, se presentan las variables psicológicas y sociodemográficas del agresor y de la víctima, así como de la relación de pareja. Y en segundo lugar, se determinan las diferencias más significativas entre la violencia grave y la violencia menos grave en relación con esas mismas variables. Los resultados ponen de manifiesto que tanto los agresores como las víctimas tienden a ser jóvenes, con una sobrerrepresentación de agresores y víctimas extranjeros inmigrantes. En el caso de los maltratadores graves, tienden a ser celosos o posesivos, a sentirse humillados por la ruptura de la pareja, lo que redunda directamente en un descenso de su autoestima y a consumir abusivamente alcohol o drogas. Por lo que se refiere a las víctimas de la violencia grave, se suelen sentir con frecuencia en peligro de muerte y están más fácilmente en circunstancias de vulnerabilidad, como una edad muy joven, una personalidad muy dependiente, una situación de enfermedad crónica o de dependencia económica, un consumo de drogas o un entorno de soledad. Se comentan las implicaciones de este estudio para la investigación y para la práctica clínica.

  1. Orden constitucional y graves violaciones de Derechos Humanos

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    Luis Jimena Quesada

    2008-01-01

    Full Text Available El presente trabajo afronta un desafío fundamental para el Derecho constitucional, a saber, el análisis del marco constitucional español referente a la responsabilidad por graves violaciones de derechos humanos. En este sentido, en primer lugar, el trabajo introduce una posición original sobre los tipos de graves violaciones de derechos humanos, las cuales están relacionadas con los más horrendos atentados contra la dignidad humana y contra las bases del sistema democrático, teniendo una proyección tanto en el plano constitucional como en el universal. A continuación, en la parte central del trabajo se examina sucesivamente siguiendo un esquema lógico las diversas etapas de lucha contra la impunidad de los individuos responsables por graves violaciones de derechos humanos: la investigación, el enjuiciamiento y la condena por esos actos criminales, sin olvidar la reparación de las víctimas. En todas esas etapas se toma en consideración el marco legal nacional (terrorismo y crímenes contra la humanidad contemplados en el Código penal y el supranacional (crímenes universales previstos en el Estatuto de la Corte Penal Internacional y en otros tratados internacionales de Derecho internacional penal y humanitario, así como en la Unión Europea; y se tiene en cuenta asimismo el progreso conocido en el ámbito de la jurisprudencia nacional (jurisdicción universal y de la jurisprudencia internacional (la puesta en funcionamiento de la Corte Penal Internacional y de los Tribunales Penales para la ex Yugoslavia y para Ruanda. Finalmente, se incluyen unas conclusiones sobre la necesidad de forjar un compromiso en la lucha contra la impunidad universal (tanto por parte de la ciudadanía como por parte de los poderes públicos, especialmente con «voluntad jurisdiccional», así como sobre los nuevos perfiles o desarrollos de los derechos fundamentales en juego (sobre todo, el derecho a la tutela judicial efectiva, el derecho a la informaci

  2. Tolerancia al ejercicio en pacientes con enfermedad pulmonar obstructiva crónica después de un programa de rehabilitación respiratoria

    OpenAIRE

    Meneses Terry, Mercedes R.

    1999-01-01

    Se expusieron los resultados de la aplicación de un programa de rehabilitación respiratoria consistente en la aplicación de ejercicios respiratorios a un grupo de pacientes con asma bronquial, bronquitis crónica y enfisema pulmonar con una duración de 36 sesiones de tratamiento, luego de las cuales se compararon los resultados con los del grupo control que sólo llevó tratamiento con medicamentos. Se observó en los tratados con el programa, un incremento en la tolerancia a los ejercicios. T...

  3. Avaliação da qualidade de vida em crianças e adolescentes com asma: Validação semântica e estudo piloto do DISABKIDS – Módulo para a Asma

    OpenAIRE

    Silva, Neuza; Carona, Carlos; Crespo, Carla; Canavarro, Maria Cristina

    2011-01-01

    A qualidade de vida tem surgido na literatura como um importante indicador de saúde. A elevada prevalência da asma na população pediátrica portuguesa torna particularmente relevante a avaliação da qualidade de vida relacionada com a saúde nesta condição. Objectivos. (1) Descrever o processo de desenvolvimento das versões Portuguesas do DISABKIDS- Módulo para a Asma; (2) avaliar a importância e compreensibilidade dos seus itens e adequação da escala de resposta (validação semântica); e (3) exa...

  4. EJERCICIO Y LA DETECCION DEL MAL AGUDO DE MONTAÑA GRAVE

    Science.gov (United States)

    Garófoli, Adrián; Montoya, Paola; Elías, Carlos; Benzo, Roberto

    2012-01-01

    El Mal Agudo de Montaña (MAM) es un conjunto de síntomas inespecíficos padecidos por sujetos que ascienden rápidamente desde baja a alta altura sin adecuada aclimatación. Usualmente es autolimitado, pero las formas graves (edema pulmonar y cerebral) pueden causar la muerte. La hipoxemia exagerada en reposo está relacionada con el desarrollo de MAM pero su valor predictivo es limitado. Dado que el ejercicio en altura se acompaña de mayor hipoxemia y síntomas, postulamos el valor predictivo de un simple test de ejercicio para pronosticar MAM grave. Se estudió el valor predictivo de la saturación de oxígeno en reposo y ejercicio submáximo a 2 700m y 4 300m en 63 sujetos que ascendían al cerro Aconcagua (6 962m). Se consideró desaturación de oxígeno con ejercicio a una disminución >=5% respecto al reposo. Se utilizó la escala de Lake-Louise para establecer la presencia de MAM grave. 6 sujetos presentaron MAM grave (9.5%) y requirieron evacuación. La saturación de oxígeno en reposo a 2 700m no fue significativa para clasificar sujetos que luego desarrollaron MAM grave. Por el contrario, la asociación de desaturación durante el ejercicio a 2 700m más la saturación inapropiada en reposo a 4 300m fue significativa para clasificar a los sujetos que desarrollaron MAM grave con un valor predictivo positivo de 80% y un valor predictivo negativo del 97%. Nuestros resultados son relevantes para el montañismo y sugieren la adición de un simple test de ejercicio en la predicción del MAM grave. PMID:20228017

  5. Factores que determinan el mal pronóstico y la exacerbación del asma en niños que asisten a consulta de alergología pediátrica Factors determining the poor prognosis and asthma exacerbation in children seen in the pediatric allergy service

    Directory of Open Access Journals (Sweden)

    Alain R. Rodríguez-Orozco

    2007-03-01

    Full Text Available El asma es una de las enfermedades de mayor impacto en la práctica pediátrica. Este es un estudio descriptivo, transversal que se realizó con el objetivo de identificar los factores que determinan la exacerbación y el mal pronóstico del asma bronquial en los niños. Se estudiaron 45 pacientes con diagnóstico de asma bronquial. Las crisis se presentaron en el hogar en el 76 % y en el 24 %, en la escuela. Los desencadenantes de las crisis agudas de asma bronquial fueron: el ejercicio (73 %, las infecciones respiratorias (57 % y la rinitis (55 %. Los factores de mal pronóstico más frecuentemente encontrados fueron: rinorrea sin catarro (60 %, sexo masculino (51 %, 3 o más episodios de sibilancias en los 6 meses previos (42 % y asma en los padres (37 %. La presencia de las exacerbaciones y los criterios de mal pronóstico repercuten en el control y en la calidad de vida del niño asmático y deben detectarse en la consulta de atención primaria.Asthma is one of the diseases with a greater impact on pediatric practice. This descriptive, cross-sectional study was undertaken to identify those factors determining the exacerbation and poor prognosis of bronchial asthma in children. Forty five patients with diagnosis of bronchial asthma were studied. The crises were developed at home in 76 % and at school in 24 % of the children. Triggering causes of acute crises of bronchial asthma were: exercise (73 %, respiratory infections (57 %, and rhinitis (55 %. The factors of poor prognosis most frequently found were: rhinorrhea without cold (60 %, male sex (51%, three or more episodes of wheezes in previous months (42 %, and asthma in parents (37 %. The presence of exacerbations and the criteria of poor prognosis influence on the control and quality of life of the asthmatic children, and they should be detected at the primary care level.

  6. Messiniense: compleja y grave crisis ecologica

    Directory of Open Access Journals (Sweden)

    Aguirre, E.

    2003-08-01

    yacimientos de mamíferos fósiles en España y otras regiones con importantes novedades, entre ellas diversos intercambios intercontinentales, en el mismo intervalo cronológico añaden cuestiones de interés además de obligar a la correlación entre la estratigrafía basada en series marinas y la biostratigrafía continental. A las singularidades de estas series se añade el descubrimiento reciente de homínidos fósiles con indicios de bipedia en edades comprendidas en este intervalo. En el mismo se han datado graves eventos paleogeográficos, geodinámicos, paleoambientales y paleoclimáticos, que empezaron a investigarse hace 40 años como la «Crisis de Salinidad del Mediterráneo*, y sobre cuyo desarrollo e interacciones se han publicado diversos modelos más o menos incompletos: aislamiento del mediterráneo, descenso global del nivel del mar, acreción continental y orogenia, glaciación, deterioro de la cubierta vegetal. Una interpretación de la secuencia de eventos en estos diversos campos de estudio de Historia de la Tierra y de la Vida, y sus interacciones, puede trazarse con una calibración del orden de los cien mil años.

  7. Towards a consensus-based biokinetic model for green microalgae – The ASM-A

    DEFF Research Database (Denmark)

    Wágner, Dorottya Sarolta; Valverde Pérez, Borja; Sæbø, Mariann

    2016-01-01

    developed to predict microalgal growth. However, none of these models can effectively describe all the relevant processes when microalgal growth is coupled with nutrient removal and recovery from wastewaters. Here, we present a mathematical model developed to simulate green microalgal growth (ASM-A) using...... and substrate availability can introduce significant variability on parameter values for predicting the reaction rates for bulk nitrate and the intracellularly stored nitrogen state-variables, thereby requiring scenario specific model calibration. ASM-A was identified using standard cultivation medium...

  8. [Serum glycosaminoglycans in Graves' disease patients].

    Science.gov (United States)

    Winsz-Szczotka, Katarzyna B; Olczyk, Krystyna Z; Koźma, Ewa M; Komosińska-Vassev, Katarzyna B; Wisowski, Grzegorz R; Marcisz, Czesław

    2006-01-01

    The aim of the study was to determine the blood serum sulfated glycosaminoglycans (GAGs) and hyaluronic acid (HA) concentration of Graves' disease patients before treatment and after attainment of the euthyroid state. The study was carried out on the blood serum obtained from 17 patients with newly recognised Graves' disease and from the same patients after attainment of the euthyroid state. Graves' patients had not any clinical symptoms neither of ophthalmopathy nor pretibial myxedema. GAGs were isolated from the blood serum by the multistage extraction and purification using papaine hydrolysis, alkali elimination, as well as cetylpyridium chloride binding. Total amount of GAGs was quantified by the hexuronic acids assay. HA content in obtained GAGs sample was evaluated by the ELISA method. Increased serum concentration of sulfated GAGs in non-treated Graves' disease patients was found. Similarly, serum HA level in untreated patients was significantly elevated. The attainment of euthyroid state was accompanied by the decreased serum sulfated GAGs level and by normalization of serum HA concentration. In conclusion, the results obtained demonstrate that the alterations of GAGs metabolism connected with Graves' disease can lead to systemic changes of the extracellular matrix properties.

  9. Komunikasi Dokter dengan Sikap Konkordansi pada Pasien Tuberkulosis Paru, Hipertensi, dan Asma

    Directory of Open Access Journals (Sweden)

    Ita Patriani

    2013-09-01

    Full Text Available Pengobatan penyakit kronik tidak hanya membutuhkan ketersediaan obat dan petugas kesehatan yaitu dokter, tetapi juga tiga faktor yakni kepatuhan (compliance, aderensi (adherency, dan konkordansi ( concordance. Ketiga faktor tersebut sangat penting dalam upaya penanganan penyakit kro-nik, termasuk tuberkulosis (TB paru, hipertensi, dan asma. Untuk mewujudkan sikap konkordansi, dibutuhkan komunikasi efektif antara dokter dan pasien. Komunikasi yang terjalin efektif akan meningkatkan pemahaman dan motivasi dalam diri pasien untuk mengikuti nasihat dari dokter. Adapun penelitian ini dilatarbelakangi oleh tingginya angka penderita dan angka kegagalan berobat ( drop out pasien tuberkulosis paru, hipertensi, asma di Rumah Sakit Umum Daerah Kota Mataram. Penelitian ini bertujuan untuk melihat hubungan komunikasi dokter dan karakteristik pasien dengan sikap konkordansi pasien. Penelitian dengan desain studi potong lintang ini dilakukan terhadap 174 pasien TB paru, hipertensi, dan asma sebagai responden. Hasil penelitian ini menunjukkan bahwa pendidikan, pengeluaran, dan komunikasi merupakan variabel yang berhubungan dengan sikap konkordansi pada pasien TB paru, hipertensi, dan asma. Rekomedasi tindak lanjut dari penelitian ini adalah peningkatan fasilitas ruangan untuk meningkatkan kenyamanan komunikasi pasien dan dokter, penyelenggaraan program pengembangan kemampuan komunikasi dokter, dan survei berkala untuk menilai proses komunikasi dokter-pasien. The therapy of chronic diseases is not only needed drugs supply and health staff, that is physician, but also three factors such as compliance, adherence, and concordance. The three of factors are crucial in the handling of chronic diseases like lung tuberculosis, hypertension, and asthma. To accomplish a concordance attitude is needed an effective communication between physician and patient. The effective communication may increase the understanding and motivation of patients to comply the physician

  10. Associação de sintomas de rinoconjuntivite e asma em adolescentes

    Directory of Open Access Journals (Sweden)

    Rita de Cássia C.M. Brito

    2009-07-01

    Full Text Available Resumo: Objectivos – Determinar a prevalência da associação de sintomas de rinoconjuntivite e asma em adolescentes, analisar se os sintomas de asma são mais intensos e frequentes entre os adolescentes com sintomas de rinoconjuntivite alérgica e avaliar se os adolescentes reconhecem os sintomas de rinoconjuntivite.Métodos – Realizou-se um estudo do tipo corte transversal com dois componentes: um estudo de prevalência e um estudo entre casos (sintomas de rinoconjuntivite, com um grupo de comparação (ausência de sintomas de rinoconjuntivite a partir de informações dos questionários aplicados na fase 3 do ISAAC, no ano de 2002, na cidade do Recife.Resultados – A prevalência da associação de sintomas de rinoconjuntivite e de provável asma foi de 5,1% (48/940; IC 95%: 3,8 %-6,6%, apenas de asma de 10,9% (103/940; IC 95%: 9,1%-13,1% e de rinoconjuntivite isolada foi de 9,7% (91/940; IC 95%: 7,9%-13%. Entre os adolescentes com sintomas de rinite, 81,3% (39/48 tinham provável asma persistente, 31,8% (48/151 dos com sintomas de asma referiam também sintomas de rinoconjuntivite. Não reconheciam os sintomas de rinoconjuntivite 65,1% (86/132 dos adolescentes que apresentavam esses sintomas.Conclusão – A associação de sintomas de rinoconjuntivite e asma é frequente e está associada à maior gravidade dos sintomas de asma. O facto de os adolescentes não reconhecerem os sintomas de rinoconjuntivite reflecte o subdiagnóstico, que pode resultar na desvalorização dos sintomas e, consequentemente, no tratamento inadequado.Rev Port Pneumol 2009; XV (4: 613-628 Abstract: Aim – Our study aimed to determine the rate of association of rhinoconjunctivitis and asthma symptoms in adolescents to analyse whether asthma symptoms are more severe and frequent in asthmatics with concomitant allergic rhinitis and assess if adolescents are aware of having

  11. ¿Hay diferencias entre la violencia grave y la violencia menos grave contra la pareja?: un análisis comparativo

    OpenAIRE

    Enrique Echeburúa; Javier Fernández-Montalvo; Paz de Corral

    2008-01-01

    En este estudio ex post facto se lleva a cabo una descripción de las características presentadas por 1.081 casos denunciados por violencia contra la mujer en las comisarías de la Ertzaintza del País Vasco. En primer lugar, se presentan las variables psicológicas y sociodemográficas del agresor y de la víctima, así como de la relación de pareja. Y en segundo lugar, se determinan las diferencias más significativas entre la violencia grave y la violencia menos grave en relación con esas mismas v...

  12. [Neonatal hyperthyroidism and maternal Graves disease].

    Science.gov (United States)

    Ben Ameur, K; Chioukh, F Z; Marmouch, H; Ben Hamida, H; Bizid, M; Monastiri, K

    2015-04-01

    The onset of Graves disease during pregnancy exposes the neonate to the risk of hyperthyroidism. The newborn must be monitored and treatment modalities known to ensure early treatment of the newborn. We report on the case of an infant born at term of a mother with Graves disease discovered during pregnancy. He was asymptomatic during the first days of life, before declaring the disease. Neonatal hyperthyroidism was confirmed by hormonal assays. Hyperthyroidism was treated with antithyroid drugs and propranolol with a satisfactory clinical and biological course. Neonatal hyperthyroidism should be systematically sought in infants born to a mother with Graves disease. The absence of clinical signs during the first days of life does not exclude the diagnosis. The duration of monitoring should be decided according to the results of the first hormonal balance tests. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  13. Neonatal Graves' Disease with Maternal Hypothyroidism.

    Science.gov (United States)

    Akangire, Gangaram; Cuna, Alain; Lachica, Charisse; Fischer, Ryan; Raman, Sripriya; Sampath, Venkatesh

    2017-07-01

    Neonatal Graves' disease presenting as conjugated hyperbilirubinemia is a diagnostic challenge because the differential includes a gamut of liver and systemic diseases. We present a unique case of neonatal Graves' disease in a premature infant with conjugated hyperbilirubinemia born to a mother with hypothyroidism during pregnancy and remote history of Graves' disease. Infant was treated with a combination of methimazole, propranolol, and potassium iodide for 4 weeks. Thyroid function improved after 8 weeks of treatment with full recovery of thyroid function, disappearance of thyroid-stimulating antibodies, and resolution of failure to thrive and conjugated hyperbilirubinemia. This case provides several clinical vignettes as it is a rare, severe, presentation of an uncommon neonatal disease, signs, symptoms, and clinical history presented a diagnostic challenge for neonatologists and endocrinologists, normal newborn screen was misleading, and yet timely treatment led to a full recovery.

  14. Changes of hepatofibrosis markers in Graves' disease

    International Nuclear Information System (INIS)

    Zhou Feihua; Xu Haifeng; Zhou Runsuo; Gao Feng; Wang Lei

    2006-01-01

    Objective: To study the changes of hepatofibrosis markers (IV-C, PC III, HA, LN) in Graves' disease. Methods: Serum levels of hepatofibrosis were measured with RIA in 40 patients with Graves' disease (CD) before any treatment and 35 patients with Graves' disease after successful anti-thyroid drug therapy as well as in 30 controls. Results: The serum IV-C and PC III levels in GD patients were significant higher than those in controls before treatment (P<0.01). After successful treatment, the IV-C, PC III levels dropped markedly (vs before treatment, P<0.01). However, there were no significant differences among the serum HA, LN levels in all the subjects tested. Conclusion: Serum levels of IV-C and PC III increased markedly with hyperthyroidim. When IV-C and PC III levels were taken for assessment of degree of hepatofibeosis, GD must be ruled out first. (authors)

  15. Pancytopenia in a Patient with Grave's Disease.

    Science.gov (United States)

    Loh, Huai Heng; Tan, Florence

    2013-08-01

    Pancytopenia can rarely complicate Grave's disease. It can be due to uncontrolled thyrotoxicosis or as a result of rare side effect of antithyroid medication. Pernicious anemia leading to Vitamin B12 deficiency is another rare associated cause. We report a case of a patient with Grave's disease and undiagnosed pernicious anemia whom was assumed to have antithyroid drug induced pancytopenia. Failure to recognize this rare association of pernicious anemia as a cause of pancytopenia had resulted in delay in treatment and neurological complication in our patient.

  16. Rituximab in relapsing Graves' disease, a phase II study

    NARCIS (Netherlands)

    Heemstra, Karen A.; Toes, Rene E.; Sepers, Jan; Pereira, Alberto M.; Corssmit, Eleonora P.; Huizinga, Tom W. J.; Romijn, Johannes A.; Smit, Johannes W.

    2008-01-01

    Conventional therapies for Graves' disease, consisting of medical therapy or radioiodine are unsatisfactory, because of limited efficacy and adverse events. Interventions aimed at the underlying autoimmune pathogenesis of Graves' disease may be worthwhile to explore. We therefore performed a

  17. Asma aguda em adultos na sala de emergência: o manejo clínico na primeira hora

    Directory of Open Access Journals (Sweden)

    DALCIN PAULO DE TARSO ROTH

    2000-01-01

    Full Text Available Asma é doença com alta prevalência em nosso meio e ao redor do mundo. Embora novas opções terapêuticas tenham sido recentemente desenvolvidas, parece haver aumento mundial na sua morbidade e mortalidade. Em muitas instituições, as exacerbações asmáticas ainda constituem emergência médica muito comum. As evidências têm demonstrado que a primeira hora no manejo da asma aguda na sala de emergência concentra decisões cruciais que podem determinar o desfecho desta situação clínica. Nesta revisão não-sistemática, os autores enfocaram a primeira hora da avaliação e tratamento do paciente com asma aguda na sala de emergência, descrevendo uma estratégia apropriada para o seu manejo. São consideradas as seguintes etapas: diagnóstico, avaliação da gravidade, tratamento farmacológico, avaliação das complicações e decisão sobre onde se realizará o tratamento adicional. Espera-se que estas recomendações contribuam para que o médico clínico tome a decisão apropriada na primeira hora do manejo da asma aguda.

  18. Comparação entre dois métodos de avaliação do controle da asma baseados na percepção individual Comparison between two methods of asthma control evaluation based on individual perception

    Directory of Open Access Journals (Sweden)

    Paula Cristina Andrade Almeida

    2012-06-01

    Full Text Available OBJETIVO: Comparar a percepção subjetiva do controle da asma informada pelo paciente com aquela obtida por meio do escore do Asthma Control Questionnaire com seis questões (ACQ-6 em pacientes com asma grave e verificar se o controle da asma está associado ao número de visitas a salas de emergência no mês anterior. MÉTODOS: Estudo transversal de 528 pacientes acompanhados na Central de Referência do Programa para Controle da Asma e Rinite Alérgica na Bahia, entre agosto de 2008 e março de 2010, em Salvador (BA. Os pacientes responderam ao ACQ-6 e a uma questão adicional específica para avaliar sua percepção do controle da doença na semana prévia. RESULTADOS: Foram avaliados 423 pacientes, que preencheram os critérios de inclusão. A maioria era do gênero feminino (81,3% e possuía renda familiar menor que dois salários mínimos (64,3%. A média de idade foi de 49,85 ± 13,71 anos, e a duração dos sintomas de asma foi de 32,11 ± 16,35 anos. Os pacientes eram regularmente tratados no programa há 36,65 ± 18,10 meses. Baseados na percepção subjetiva do controle, 8% dos pacientes consideraram a sua asma não controlada, enquanto 38,8% obtiveram escore do ACQ > 1,5, indicando falta de controle. O coeficiente kappa revelou fraca concordância entre os dois métodos. Houve uma associação direta entre falta de controle e número de visitas a emergência no mês anterior (p OBJECTIVE: To compare the subjective perception of asthma control reported by the patient with that measured by the score obtained on the Asthma Control Questionnaire 6-item version (ACQ-6 in patients with severe asthma and to determine whether asthma control is associated with the number of emergency room visits in the previous month. METHODS: This was a cross-sectional study involving 528 patients treated at the Bahia State Asthma and Allergic Rhinitis Control Program Central Referral Clinic between August of 2008 and March of 2010, in the city of Salvador

  19. Enfermedad de Graves y cáncer de tiroides: Reporte de caso

    Directory of Open Access Journals (Sweden)

    Helard Manrique-Hurtado

    2011-01-01

    Full Text Available Se reporta el caso de una mujer de 62 años con antecedente de cáncer de recto curado, con Enfermedad de Graves de reciente diagnóstico. El examen físico mostró un bocio difuso y presencia de un nódulo en el polo inferior del lóbulo derecho. El perfil tiroideo mostró un TSH suprimido y hormonas tiroideas aumentadas. Los anticuerpos antitiroideos fueron negativos. La ecografía de tiroides confirmó la presencia de un nódulo sólido en la tiroides y ganglios linfáticos aumentados de tamaño. La gammagrafía de tiroides mostró una glándula aumentada de tamaño, hipercaptadora, con presencia de un nódulo frío en el lóbulo derecho. El estudio histopatológico luego de la tiroidectomía total mostró cáncer papilar moderadamente diferenciado, con invasión local y metástasis ganglionares. La coexistencia de enfermedad de Graves y cáncer de tiroides ha sido reportada hasta en 9% de los pacientes. El tumor es más agresivo presentando metástasis a ganglios o a distancia. En general, se debería incluir a la ecografía tiroidea en la evaluación inicial de los pacientes con enfermedad de Graves, especialmente, en los que presentan nódulos tiroideos palpables. (Rev Med Hered 2011;22:34-37.

  20. Sjiele sacrifices, Odin treasures and Saami graves?

    Directory of Open Access Journals (Sweden)

    Inger Zachrisson

    1987-01-01

    Full Text Available This paper presents archaeological findings described as Saami metal deposits. These well-known "Finds from Lapp Places of Sacrifice", objects from the Viking Age and Early Middle Ages, were mostly found in northern Sweden. The author also presents a research project dealing with prehistoric and medieval Saami graves from the south Saami area.

  1. Graves' orbitopathy: Management of difficult cases

    NARCIS (Netherlands)

    Wiersinga, Wilmar M.

    2012-01-01

    Management of Graves' ophthalmopathy (GO) is based on three pillars: to stop smoking, to restore and maintain euthyroidism, and to treat the eye changes according to severity and activity of GO. Difficulties are frequently encountered in each of these three management issues. The advice to

  2. Graves' disease: thyroid function and immunologic activity

    International Nuclear Information System (INIS)

    Gossage, A.A.; Crawley, J.C.; Copping, S.; Hinge, D.; Himsworth, R.L.

    1982-01-01

    Patients with Graves' disease were studied for two years during and after a twelve-month course of treatment. Disease activity was determined by repeated measurements of thyroidal uptake of [/sup 99m/Tc]pertechnetate during tri-iodothyronine administration. These in-vivo measurements of thyroid stimulation were compared with the results of in-vitro assays of Graves, immunoglobulin (TSH binding inhibitory activity--TBIA). There was no correlation between the thyroid uptake and TBIA on diagnosis. Pertechnetate uptake and TBIA both declined during the twelve months of antithyroid therapy. TBIA was detectable in sera from 19 of the 27 patients at diagnosis; in 11 of these 19 patients there was a good correlation (p less than 0.05) throughout the course of their disease between the laboratory assay of the Graves, immunoglobulin and the thyroid uptake. Probability of recurrence can be assessed but sustained remission of Graves' disease after treatment cannot be predicted from either measurement alone or in combination

  3. Plantas cubanas con efecto antiinflamatorio

    Directory of Open Access Journals (Sweden)

    Ada Ivis Regalado Veloz

    Full Text Available La actividad antiinflamatoria suscita gran interés científico en el área farmacológica, debido a que muchas enfermedades en su evolución cursan por procesos inflamatorios (artritis reumatoide, ateroesclerosis, cáncer, diabetes, gota, asma, dermatitis, trastornos neurodegenerativos y diversas dolencias menores. Las enfermedades inflamatorias constituyen un problema de salud importante, debido a la falta de medicamentos eficaces y seguros para su uso por periodos prolongados. Hoy en día se trabaja en la búsqueda de alternativas de antiinflamatorios más seguros, en el que las plantas medicinales, una de las formas más antiguas de tratamiento, constituyen una elección a considerar. En este trabajo se realizó una revisión bibliográfica, sobre especies de plantas que crecen en Cuba que le reportan propiedades farmacológicas como antinflamatorios. En la revisión de la literatura se utilizó la base de datos Medline (vía PubMed, así como revistas nacionales desde el periodo de 2000 hasta el presente, con las palabras claves "inflamación" y "plantas cubanas antiinflamatorias" o "actividad antiinflamatoria" y "plantas medicinales".

  4. Estrategia de intervención para la monitorización y reducción de las crisis de asma bronquial aplicando un sistema de alerta temprana Intervention strategy for monitoring and reduction of bronchial asthma crises applying an early alert system

    Directory of Open Access Journals (Sweden)

    Tatiana de la Vega Pazitková

    2011-06-01

    Full Text Available Introducción: el asma es una enfermedad psicosomática que constituye un importante problema de salud mundial. El clima y el tiempo influyen sobre la salud humana. Es conocida la influencia de los factores ambientales en la aparición de las crisis agudas de asma bronquial. Objetivo: diseñar una estrategia de intervención comunitaria, sobre la base de la asociación del asma con los cambios meteorotrópicos, con el fin de alertar, tempranamente, de la posibilidad de desencadenamiento de las manifestaciones clínicas, mitigarlas y reducir las crisis de asma. Métodos: se diseñó un plan de acción que incluye a médicos, los pacientes y sus tutores que acudieron al servicio de urgencia del policlínico "Ana Betancourt", y sus consultorios médicos, durante el año 2010. Todos se adiestraron en la interpretación y procesamiento del modelo de pronóstico biometeorológico, cuyos resultados alertará sobre su accionar diario ante los riesgos meteorotrópicos. Resultados: se propone una estrategia de intervención comunitaria, con el fin de reducir, en al menos 20 %, el número de pacientes con crisis de asma, y su gravedad. Conclusiones: los factores ambientales influyen en la aparición de las crisis agudas de asma bronquial. Las condiciones de hiperoxia o aumento de la densidad parcial de oxígeno en el aire son predecibles, y se puede alertar, oportunamente, a las autoridades de salud sobre su ocurrencia, lo que permite ejecutar planes de acción y medidas profiláctico preventivas que minimicen los impactos desfavorables de los cambios de tiempo anunciados.Introduction: asthma is a psychosomatic disease becomes important health problem at world scale. The climate and time influenced on the human health. It is known the influence of environmental factors on the appearance of acute crises of bronchial asthma. Objective: to design a community intervention strategy based on the association of asthma with the meteorotropic changes to alert early

  5. Consumo de alimentos y asma en niños escolares de Cuernavaca Food consumption and asthma in school children in Cuernavaca, Morelos, Mexico

    Directory of Open Access Journals (Sweden)

    Rosa Inés Gutiérrez-Delgado

    2009-06-01

    Full Text Available OBJETIVO:Evaluar la relación entre la dieta y el desarrollo de asma y rinitis alérgica en escolares de Cuernavaca, Morelos, México. MATERIAL Y MÉTODOS: Se aplicó el cuestionario ISAAC (International Study of Asthma and Allergies in Childhood a 5 460 niños de entre 6 a 8 y 11 a 14 años de edad, de nivel primaria, seleccionados de manera aleatoria. Se formaron seis grupos de alimentos a partir de un análisis de clusters jerárquico y se evaluó la relación con los padecimientos a través de modelos de regresión logística. RESULTADOS:El consumo de comida rápida tuvo un efecto adverso sobre la sibilancia actual (RM=1.82; IC95%=1.16-2.87 y el consumo de golosinas sobre más de tres episodios de sibilancia (RM=2.26; IC95%=1.04-4.95 y síntomas nasales sin gripa o catarro (RM=1.35; IC95%=1.06-1.71. CONCLUSIONES:Este estudio provee evidencia de que la dieta juega un papel muy importante, ya que el consumo abundante de comida rápida y golosinas incrementa el riesgo de asma y rinitis.OBJECTIVE:To evaluate the relation between diet and the development of asthma and allergic rhinitis in schoolchildren from Cuernavaca, Morelos, Mexico. MATERIAL AND METHODS:We apply the ISAAC's questionnaire in 5460 schoolchildren from 6 to 8 and 11-14-year-old of elementary level selected in random form. Six groups of food were formed using a hierarchic clusters analysis and the association was evaluated using logistic regression models. RESULTS:The consumption of fast food had an adverse effect for current wheezing (OR=1.82; CI95%=1.16-2.87 and the consumption of tidbits for more than three episodes of wheezing (OR=2.26; CI95%=1.04-4.95 and nasal symptoms without cold, OR=1.35 (IC95%;1.06-1.71. CONCLUSIONS:This study provides evidence that the diet plays a very important role since the high consumption of fast food and tidbits increased the risk of asthma and rhinitis symptoms.

  6. Significados culturais da asma infantil Cultural meanings of the infantile asthma

    Directory of Open Access Journals (Sweden)

    Mirna Albuquerque Frota

    2008-06-01

    Full Text Available OBJETIVO: Analisar os significados culturais da asma infantil com origem na mãe-cuidadora. PROCEDIMENTOS METODOLÓGICOS: Pesquisa qualitativa realizada em 2004, no município de Fortaleza, CE. Foi utilizada a observação participante com abordagem etnográfica e entrevistas com sete mães acompanhantes de seus filhos em unidade de emergência hospitalar. Os significados das falas das mães foram identificados utilizando-se a técnica de análise temática. ANÁLISE DOS RESULTADOS: Foram identificadas duas categorias de discussão; na primeira, "desinformação sobre a doença", foi possível perceber que as mães não são informadas sobre a doença do filho. Na segunda categoria, "cuidado cultural", as mães referem informações sobre os cuidados e utilizam recursos do saber popular para prevenir a asma dos filhos, como o cuidado ambiental e a utilização de remédios caseiros à base de plantas medicinais. CONCLUSÕES: As características de desinformação e desconhecimento materno em relação à asma do filho mostram a necessidade de haver um trabalho educativo intenso, dialógico e problematizador em estreita colaboração com o tratamento, visando à melhoria do prognóstico da doença.OBJECTIVE: To analyze the cultural meanings of infantile asthma from the perspective of the mother/carer of the child. METHODOLOGICAL PROCEDURES: Qualitative research conducted in 2004, in the city of Fortaleza (Northeastern Brazil. An ethnographic approach was utilized, consisting of participant observation and interviews with seven mothers, accompanying their children in a hospital emergency ward. Thematic analysis was the technique employed when identifying the meanings of mothers' discourse. ANALYSIS OF RESULTS: Two discussion categories were identified: "disinformation on illness" in which it was possible to perceive that the mothers were not informed with respect to their children's illness; and "cultural care" in which they relate information on

  7. Effect of 131I therapy on outcomes of Graves' ophthalmopathy

    International Nuclear Information System (INIS)

    Wang Renfei; Tan Jian; Zhang Guizhi; Yin Liang

    2011-01-01

    Objective: To analyze the correlation between the therapeutic effect of Graves' hyperthyroidism and the outcomes of Graves' ophthalmopathy after 131 I therapy, and to explore the effect of 131 I treatment on turnout of Graves' ophthalmopathy. Methods: Six hundreds and fifty-two patients of Graves' disease accompanied with Graves' ophthalmopathy, received one-time 131 I treatment according to routine procedure. We recorded exophthalmometer readings, the signs and symptoms of eyes before therapy. Regular follow-up and appraisal of curative effect were carried out. Results: At least six months after 131 I therapy, the effective rate of Graves' hyperthyroidism and Graves' ophthalmopathy were 94.3% and 73.3% respectively. The total effective rate of hyperthyroidism with ophthalmopathy was 71.2%. There was a significant correlation between the prognosis of Graves' ophthalmopathy and therapeutic efficacy of hyperthyroidism (r=0.302, P 131 I therapy (χ 2 =0.296, P>0.05). Conclusions: The key to treat Graves' ophthalmopathy is the cure of Graves' hyperthyroidism through 131 I therapy. The timely diagnosis and replacement treatment of hypothyroidism can effectively avoid the aggravation of Graves' ophthalmopathy after 131 I therapy. (authors)

  8. Follow up of Graves' Opthalmopathy after radioiodine therapy

    International Nuclear Information System (INIS)

    Miah, M.S.R.; Paul, A. K.; Rahman, H.A.

    2002-01-01

    Graves' ophthalmopathy may first appear or worsen during or after treatment for hyperthyroidism. We followed up 158 Graves' hyperthyroid patients treated with radioiodine of which 49 had Grave's' ophthalmopathy during presentation in Nuclear Medicine Centre, Khulna during the period from 1995 to 2000. The aim of our study is to see the effect of radioiodine in Graves' ophthalmopathy. All the patients received radioiodine at fixed dose regime ranged from 7 mCi to 12 mCi. The duration of follow up was at least 12 months Graves' ophthalmopathy patients, 4 (4/49 i.e., 8.2%) showed exaggeration of ophthalmopathy and the rest (45/49 i.e., 91.8%) remained unchanged. None of ophthalmopathy developed among any of Graves' hyperthyroid or disappeared after radioiodine treatment during follow up period. From the study we concluded that eye changes in Graves' hyperthyroidism remain unchanged or exaggerated after radioiodine therapy and needs ophthalmologist care.(author)

  9. Thyroid cancer in Graves' disease: is surgery the best treatment for Graves' disease?

    Science.gov (United States)

    Tamatea, Jade A U; Tu'akoi, Kelson; Conaglen, John V; Elston, Marianne S; Meyer-Rochow, Goswin Y

    2014-04-01

    Graves' disease is a common cause of thyrotoxicosis. Treatment options include anti-thyroid medications or definitive therapy: thyroidectomy or radioactive iodine (I(131) ). Traditionally, I(131) has been the preferred definitive treatment for Graves' disease in New Zealand. Reports of concomitant thyroid cancer occurring in up to 17% of Graves' patients suggest surgery, if performed with low morbidity, may be the preferred option. The aim of this study was to determine the rate of thyroid cancer and surgical outcomes in a New Zealand cohort of patients undergoing thyroidectomy for Graves' disease. This study is a retrospective review of Waikato region patients undergoing thyroid surgery for Graves' disease during the 10-year period prior to 1 December 2011. A total of 833 patients underwent thyroid surgery. Of these, 117 were for Graves' disease. Total thyroidectomy was performed in 82, near-total in 33 and subtotal in 2 patients. Recurrent thyrotoxicosis developed in one subtotal patient requiring I(131) therapy. There were two cases of permanent hypoparathyroidism and one of permanent recurrent laryngeal nerve palsy. Eight patients (6.8%) had thyroid cancer detected, none of whom had overt nodal disease. Five were papillary microcarcinomas (one of which was multifocal), two were papillary carcinomas (11 mm and 15 mm) and one was a minimally invasive follicular carcinoma. Thyroid cancer was identified in approximately 7% of patients undergoing surgery for Graves' disease. A low complication rate (<2%) of permanent hypoparathyroidism and nerve injury (<1%) supports surgery being a safe alternative to I(131) especially for patients with young children, ophthalmopathy or compressive symptoms. © 2012 The Authors. ANZ Journal of Surgery © 2012 Royal Australasian College of Surgeons.

  10. Asma de exercício : foco na fisiopatolgia e fatores de risco

    OpenAIRE

    Vieira, Inês Sofia Henriques

    2015-01-01

    Trabalho final de mestrado integrado em Medicina área científica de Imunologia Clínica, apresentado á Faculdade de Medicina da Universidade de Coimbra Hiperreatividade das vias aéreas ao exercício refere-se a um estreitamento transitório das vias aéreas após o exercício. Pode surgir em indivíduos asmáticos (asma induzida pelo exercício) ou isoladamente (broncoconstrição induzida pelo exercício). A prevalência desta patologia depende das características da população estudada, tendo...

  11. Qualidade de vida em doentes com asma Quality of life in asthma patients

    OpenAIRE

    Lara Noronha Ferreira; Ulisses Brito; Pedro Lopes Ferreira

    2010-01-01

    Neste artigo é descrito um estudo, cujo objectivo é a medição da qualidade de vida relacionada com a saúde (QdVRS) de doentes com asma e a apresentação de uma primeira aproximação aos valores normativos, com base no SF-6D, para aquele tipo de doentes. Pretende-se ainda averiguar a capacidade de medidas genéricas de medição da QdVRS distinguirem grupos em termos de características sociodemográficas. Aplicaram-se, por entrevista pessoal, as versões portuguesas do EQ-5D, do SF-6D, do AQLQ(S) e d...

  12. Asma induzida pelo exercício: aspectos atuais e recomendações

    OpenAIRE

    Laitano,Orlando; Meyer,Flávia

    2007-01-01

    OBJETIVO: Descrever os mecanismos da asma induzida pelo exercício (AIE), bem como os efeitos de diferentes tipos de treinamento físico na função pulmonar e nas capacidades aeróbia e anaeróbia. Destaca-se a importância de um diagnóstico correto mediante o teste de exercício e, no manejo, o uso de drogas beta-adrenérgicas e anticolinérgicas. FONTE DOS DADOS: Os artigos foram criteriosamente escolhidos utilizando as bases de dados PubMed e Scielo pelo ano de publicação e dando preferência a ensa...

  13. Asma y actividad física. Revisión

    OpenAIRE

    Corbi, Francesc; Baiget i Vidal, Ernest; Bofill, A.

    2014-01-01

    El asma es una enfermedad inflamatoria crónica de elevada prevalencia a nivel mundial, siendo el colectivo más afectado el formado por niños y adolescentes. Su sintomatología se caracteriza por la aparición de tos, disnea, sibilancias, sensación de opresión en el pecho y broncoconstricción. Tradicionalmente se había pensado que el deporte y el ejercicio físico estaban contraindicados en pacientes asmáticos. Por otro lado, el paciente asmático suele presentar niveles de condición física y prác...

  14. The microclimate within a Neolithic passage grave

    DEFF Research Database (Denmark)

    Klenz Larsen, Poul; Aasbjerg Jensen, Lars; Ryhl-Svendsen, Morten

    2017-01-01

    Microclimate measurements in a Neolithic passage grave in Denmark have shown that natural ventilation through the open entrance destabilizes the relative humidity (RH), whereas a sealed entrance gives a much more stable RH, above 90%. Episodes of condensation occur on the stone surfaces in summer...... with too much ventilation and in winter with too little ventilation. Soil moisture measurements above, below, and beside the grave mound indicate that rainfall on the mound is not a significant source of moisture to the chamber, whereas the ground below the sealed chamber is constantly moist. The chamber...... can be kept dry all year by putting a moisture barrier membrane over the floor. Apart from the more variable climate within the open chamber, there is also a significant penetration of ozone, which is absent in the sealed chamber. The ozone may have deteriorated the folds of birch bark put between...

  15. Hyperthyroidism: diagnosis and management of Graves' disease.

    Science.gov (United States)

    Schilling, J S

    1997-06-01

    Hyperthyroidism, or thyrotoxicosis, results when the body's tissues are exposed to excessive levels of thyroid hormone. Hyperthyroidism affects 2% of women but only one-tenth as many men. Graves' disease is the most common form of hyperthyroidism, often occurring in young adults. It is an autoimmune disorder with an important genetic component. Hyperthyroidism's hallmarks include goiter and myriad signs and symptoms related to increased metabolic activity in virtually all body tissues. Increased sensitivity to circulating catecholamines adds to the clinical picture. Diagnosed by patient history, physical examination, and laboratory tests, Graves' disease is treated with antithyroid drugs, radioactive iodine, and/or surgery, plus supportive therapy. A good treatment outcome can be expected; long-term follow-up is indicated.

  16. A mild Grave's ophthalmopathy during pregnancy.

    Science.gov (United States)

    Abbouda, Alessandro; Trimboli, Pierpaolo; Bruscolini, Alice

    2014-01-01

    Thyroid ophthalmopathy is a complication most commonly associated with Grave's disease. The disease course ranges from mild to severe, with severe cases resulting in major visual impairment. A complete ophthalmic examination in a 35-year-old secundigravida to 14 weeks of gestation presented to the hospital for a routine ophthalmological examination with eyelid retraction in the right eye was made. We studied the course of ocular disease through the gestation with orbit ecography and a 3T MRI. A diagnosis of Grave's Ophthalmopathy was made. This case presents an unusual course of the GD during pregnancy and a normal post-partum relapse, according to the Th1/Th2 balance. The frequent follow-up and the use of MRI allowed a prompt identification and complete control of the disease.

  17. Osteogenesis imperfecta in combination with Graves disease

    Directory of Open Access Journals (Sweden)

    Marina S. Sheremeta

    2017-12-01

    Full Text Available Osteogenesis imperfecta (OI – is a group of genetically disorders, which are charaterized by a disturbed bone formation. In turn, the excess of thyroid hormones in Graves' disease (GD also posses a negative effect on bone tissue, thereby aggravating OI. That requires from the endocrinologist the most careful management of patients with the combination of these pathologies. In this article, we present a unique clinical case of a combination of GD and OI.

  18. Graves hyperthyroidism and pregnancy: a clinical update.

    Science.gov (United States)

    Patil-Sisodia, Komal; Mestman, Jorge H

    2010-01-01

    To provide a clinical update on Graves' hyperthyroidism and pregnancy with a focus on treatment with antithyroid drugs. We searched the English-language literature for studies published between 1929 and 2009 related to management of hyperthyroidism in pregnancy. In this review, we discuss differential diagnosis of hyperthyroidism, management, importance of early diagnosis, and importance of achieving proper control to avoid maternal and fetal complications. Diagnosing hyperthyroidism during pregnancy can be challenging because many of the signs and symptoms are similar to normal physiologic changes that occur in pregnancy. Patients with Graves disease require prompt treatment with antithyroid drugs and should undergo frequent monitoring for signs of fetal and maternal hyperthyroidism and hypothyroidism. Rates of maternal and perinatal complications are directly related to control of hyperthyroidism in the mother. Thyroid receptor antibodies should be assessed in all women with hyperthyroidism to help predict and reduce the risk of fetal or neonatal hyperthyroidism or hypothyroidism. The maternal thyroxine level should be kept in the upper third of the reference range or just above normal, using the lowest possible antithyroid drug dosage. Hyperthyroidism may recur in the postpartum period as Graves disease or postpartum thyroiditis; thus, it is prudent to evaluate thyroid function 6 weeks after delivery. Preconception counseling, a multidisciplinary approach to care, and patient education regarding potential maternal and fetal complications that can occur with different types of treatment are important. Preconception counseling and a multifaceted approach to care by the endocrinologist and the obstetric team are imperative for a successful pregnancy in women with Graves hyperthyroidism.

  19. Thyroidectomy for Graves' disease: is hypothyroidism inevitable?

    OpenAIRE

    Davenport, M.; Talbot, C. H.

    1989-01-01

    The outcome of 234 patients with Graves' disease treated by subtotal thyroidectomy over a 12-year period is analysed with specific reference to hypothyroidism. Of definite hypothyroid cases, 98% occurred within 2 years. Failure to develop hypothyroidism was statistically related to large remnant size and a large goitre preoperatively. Histological review showed that any degree of lymphocytic infiltration was associated with the development of hypothyroidism (50% vs 22%). Late onset hypothyroi...

  20. Resultados do tratamento da pancreatite aguda grave

    Directory of Open Access Journals (Sweden)

    Franz Robert Apodaca-Torrez

    Full Text Available OBJETIVO: Avaliar os resultados do Protocolo de Atendimento de pacientes com diagnóstico de pancreatite aguda grave. MÉTODOS: Foram analisados, consecutivamente, a partir de janeiro de 2002, idade, sexo, etiologia, tempo de internação, tipo de tratamento e mortalidade de 37 pacientes portadores de pancreatite aguda grave. RESULTADOS: A idade dos pacientes variou de 20 a 88 anos (média de 50 anos; 27% foram do sexo feminino e 73% do masculino. O tempo médio global de internação foi 47 dias. Treze pacientes foram tratados cirurgicamente; a média de operações realizadas foi duas por paciente. Ocorreram seis óbitos dentre os pacientes submetidos ao tratamento cirúrgico (46% e dois óbitos no grupo submetido somente ao tratamento clínico (8,3%. A mortalidade global foi 21% CONCLUSÃO: Após a modificação na forma de abordagem dos pacientes com pancreatite aguda grave, houve diminuição da mortalidade e uma tendência para a conduta expectante.

  1. Grave Tending: With Mom at the Cemetery

    Directory of Open Access Journals (Sweden)

    Carolyn Ellis

    2003-05-01

    Full Text Available This autoethnographic story shows the process of tending the graves of family members. In the past, the author reluctantly accompanied her mother on her visits to the family cemetery. Once there, she took on the role of distant observer as her mother took care of the family cemetery plots. When her mother becomes disabled, the author begins to arrange the flowers on the graves. Doing so leads her to examine the meaning of visiting the cemetery, feel and connect with her losses, and consider the customs she wants to be part of her own death. When her mother dies, the next generation of women in the family—the author, her sister, and sister-in-law—take on the role of tending the graves, connected in their love and respect for their mother and their feelings of family and family responsibility. This story examines the meanings of family rituals around death and how they are passed from generation to generation. URN: urn:nbn:de:0114-fqs0302285

  2. Infección odontogénica grave: Posibles factores predictores

    Directory of Open Access Journals (Sweden)

    Oscar García-Roco Pérez

    2003-04-01

    Full Text Available Se analizaron factores que pudieran predisponer a una infección odontogénica grave que requiera cuidados intensivos. Se realizó un estudio observacional descriptivo a 100 pacientes ingresados consecutivamente con infección odontogénica severa en el Hospital "Manuel Ascunce Domenech" de Camagüey desde 1999 al 2001. A partir de las historias clínicas se estudiaron diferentes variables que incluyeron parámetros médicos, sociales y procedimientos dentales previos. Se prestó particular atención al resultado de los cultivos bacterianos. La edad media de los 59 pacientes masculinos y 41 femeninos fue de 41 ± 15,8 años; 18 pacientes requirieron cuidados intensivos. El 41 % de los pacientes era de bajo nivel de escolaridad; 11 pacientes graves (61,1 % y 42 no graves (51,2 % eran fumadores. Dos pacientes (11,1 % de los graves y 8 (9,8 % de los no graves referían consumo excesivo de bebidas alcohólicas. La prevalencia de enfermedades crónicas fue mayor entre los no graves (31,7 %. La afección subyacente más común fue la osteítis periapical (70 % de los episodios infecciosos, seguido por la extracción dental en el 27,5 % de los graves y 10,9 % de los no graves. Ninguno de estos factores predijo la necesidad de cuidados intensivos. No existieron diferencias significativas en cuanto a síntomas, demora en solicitar atención médica, procedimientos dentales previos o terapéutica antimicrobiana. Predominaron los estreptococos aerobios (grupo S. milleri asociados con bacterias anaerobias variadas. No se encontraron variables sociales o clínicas predictoras de un curso grave en infecciones odontogénicas. Todos los pacientes deben ser cuidadosamente monitoreados para evitar complicaciones severas.Those factors that may predispose to a severe odontogenic infection requiring intensive care were analyzed. An observational descriptive study was conducted among 100 patients that were consecutively admitted with severe odontogenic infection at

  3. Conocimientos y actitudes ante el asma de los profesores de centros escolares de educación infantil, educación primaria y educación secundaria obligatoria del área territorial Madrid-capital

    OpenAIRE

    Miguel Lavisier, Begoña de

    2016-01-01

    El asma es la enfermedad crónica más frecuente en la infancia. Diferentes factores de riesgo influyen en la evolución de los pacientes asmáticos, unos en el desarrollo del asma y otros como desencadenante de los síntomas. Las medidas dirigidas a evitar estos últimos son básicas en el tratamiento del asma, y por lo tanto los pacientes y sus cuidadores deben aprender a identificarlos. El tratamiento del asma en los niños se basa en un plan individualizado que incluya el ajuste del tratamiento f...

  4. [Association Budd Chiari syndrome, antiphospholipid syndrome and Grave's disease].

    Science.gov (United States)

    Mouelhi, Leila; Chaieb, Mouna; Debbeche, Radhouane; Salem, Mohamed; Sfar, Imene; Trabelsi, Sinda; Gorgi, Yosr; Najjar, Taoufik

    2009-02-01

    Antiphospholipid syndrome is revealed by Budd Chiari syndrome in 5% of the cases. Antiphospholipid syndrome is characterized by venous or arterial thrombosis, foetal loss and positivity of antiphospholipid antibodies, namely lupus anticoagulant, anticardiolipin antibodies and anti-beta2-glycoprotein I. Anticardiolipin antibodies was reported in auto-immune thyroid disorders, particularly in Grave's disease. Antiphospholipid syndrome associated to Grave's disease was reported in only three cases. To describe a case report of association of Grave's disease and antiphospholipid syndrome. We report the first case of Grave's disease associated with antiphospholipid syndrome, revealed by Budd Chiari syndrome. Our observation is particular by the fact that it is about a patient presenting a Grave's disease associated with antiphospholipid syndrome revealed by Budd Chiari syndrome. This triple association has never been reported in literature. Although association between antiphospholipid syndrome and Grave's disease was previously described, further studies evaluating the coexistence of these two affections in the same patient would be useful.

  5. Lack of Clinical Relevance of ANA and ASMA Positivity in Patients with Liver Transplantation without a History of Autoimmune Diseases.

    Science.gov (United States)

    Pellegrini, Lucienne; Parrilli, Gianpaolo; Santonicola, Antonella; Cinquanta, Luigi; Caputo, Cesare; Ciacci, Carolina; Zingone, Fabiana

    2017-01-01

    The relevance of isolated autoimmunity elevation in orthotopic liver transplantation (OLT) patients is unknown. Our aim was to analyse how serum autoantibodies change in time and to evaluate their clinical relevance in OLT patients. Patients were invited to provide samples to evaluate ANA, AMA, ASMA, and LKM at the time of enrolment ( T 0), after 6 months ( T 6), and after 12 months ( T 12). We included 114 patients in the study (76% males, median age 62.5 years), finding isolated elevation of at least one serum antibody in up to 80% of them. We described fluctuating positive autoantibodies in the one year of observation, with only 45.6% of patients positive for ANA and less than 2% positive for ASMA, at all three times. Isolated elevation of tissue antibodies was not related to gender, age, HCC at transplant, early rejection, cause of transplantation, immunotherapy taken, and age at the time of the study. We did not detect a higher prevalence of positive autoimmunity in patients with signs of liver injury. ANA and ASMA evaluation in patients with liver transplantation and no history of autoimmune disease has no clinical relevance, since it varies in time and is not related to any risk factors or liver injury. Routine autoimmunity evaluation should be avoided.

  6. Grave number 121 of the argaric site of Castellón Alto (Galera, Granada

    Directory of Open Access Journals (Sweden)

    Molina, Fernando

    2003-06-01

    Full Text Available A new grave with partly mummified bodies was discovered during fieldwork to prepare the argaric site of Castellón Alto for public visits. Timber slabs and a dry stone wall seal the artificial cave preserving the interior. The human bones belong to one adult and one infant, both with preserved hair and skin fragments. The grave goods comprise several pottery vessels, one dagger, one ax with wooden handle, metal ornaments and fragments of flax and possibly wool.

    Recientes excavaciones en el yacimiento argárico de Castellón Alto con motivo de los trabajos de acondicionamiento para su visita publica han permitido descubrir una sepultura con restos humanos momificados en su interior. La sepultura de tipo covacha se encontraba sellada por tablones de madera y un muro de mampostería. En el interior aparecieron un individuo adulto y un infantil que conservan restos de pelo y piel. El ajuar se compone de varias vasijas cerámicas, un puñal, una azuela con mango de madera y adornos en metal, así como restos de lino y posiblemente lana.

  7. Tabagismo passivo e gravidade da asma brônquica na criança

    Directory of Open Access Journals (Sweden)

    Elsa Pargana

    2001-01-01

    Full Text Available RESUMO: A importância da exposição tabágica ambiencial na patogénese da asma brônquica infantil tem sido documentada, podendo relacionar-se com a sua gravidade e limitação da função pulmonar.Objectivo: Avaliar a importância da exposição tabágica como factor de gravidade, relacionado com o internamento hospitalar, na asma brônquica infantil.Métodos: Foram caracterizados os hábitos tabágicos de 128 famílias de crianças, com uma idade média de 4.3 anos, internadas por exacerbação de asma, durante um período de dois anos, correlacionando os dados obtidos com os de uma amostra de crianças observadas na consulta, emparelhada poridade, sexo e meio sócio-económico-cultural.Resultados: Os hábitos tabágicos eram significativamente mais elevados nas famílias das crianças internadas, estando presentes em 80% destas comparativamente a 46% das famílias das crianças observadas na consulta (p<0.0001. As crianças sujeitas a exposição tabágica apresentavam um risco relativo de 4.6 (IC95%=2.6-8.0 para internamento hospitalar. O pai foi identificado como o principal responsável pelo tabagismo passivo em ambas as populações (p<0.0001; OR=3.0, IC95%=1.8-4.9. Na amostra de crianças internadas o número de mulheres fumadoras era significativamente superior (35% ao observado na população da consulta (23%: p=0.04; OR=1.8, IC95%=1.0-3.1.Conclusõo: A existência de tabagismo passivo parental, em particular materno, é um factor de risco significativo para a gravidade da asma brônquica infantil. A prevenção primária, com evicção da exposição tabágica na criança, deverá ser o objectivo a atingir.REV PORT PNEUMOL 2001; VII (1: ABSTRACT: There is an increasing evidence that passive smoking is involved in the etiology of childhood asthma and may be related to its severity and to pulmonary function limitation.Purpose: To evaluate if environmental tobacco smoke exposure could be a risk factor for childhood asthma admission

  8. Diagnosis of Grave's disease with pulmonary hypertension on chest CT.

    Science.gov (United States)

    Lee, Hwa Yeon; Yoo, Seung Min; Kim, Hye Rin; Chun, Eun Ju; White, Charles S

    To evaluate the diagnostic accuracy of chest CT findings to diagnose Grave's disease in pulmonary hypertension. We retrospectively evaluated chest CT and the medical records of 13 patients with Grave's disease with (n=6) or without pulmonary hypertension (n=7) and in 17 control patients. Presence of iso-attenuation of diffusely enlarged thyroid glands compared with adjacent neck muscle on non-enhanced CT as a diagnostic clue of Grave's disease, and assessment of pulmonary hypertension on CT has high diagnostic accuracy. Chest CT has the potential to diagnose Grave's disease with pulmonary hypertension in the absence of other information. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Efecto del tabaquismo, los síntomas respiratorios y el asma sobre la espirometría de adultos de la Ciudad de México Effect of tobacco smoking, respiratory symptoms and asthma on spirometry among adults attending a check-up clinic in Mexico City

    Directory of Open Access Journals (Sweden)

    Justino Regalado-Pineda

    2005-10-01

    Full Text Available OBJETIVO: Evaluar el efecto del tabaquismo, los síntomas respiratorios y el asma sobre la función pulmonar espirométrica en población adulta mexicana. MATERIAL Y MÉTODOS: Se generaron ecuaciones de predicción basadas en modelos de regresión lineal múltiple para la capacidad vital forzada (FVC, el vollumen espiratorio forzado al primer segundo (FEV1 y FEV1/FVC de espirometrías obtenidas de adultos que acuden a evaluación de salud y se determinó el efecto del tabaquismo, los síntomas respiratorios y el asma sobre los modelos de estos parámetros. RESULTADOS: Se estudiaron 919 sujetos de entre 14 y 86 años de edad. El asma disminuye la FVC y el FEV1 en hombres con un cambio en la R² OBJECTIVE: To evaluate the effect of tobacco smoking, respiratory symptoms, and asthma on lung function among Mexican adults who were evaluated during a medical exam in a private health clinic. MATERIAL AND METHODS: Reference prediction equations were generated for spirometry parameters [forced vital capacity (FVC, forced expired volume in one second (FEV1 and FEV1/FVC] based on multiple linear regression models. The effect of tobacco smoking, respiratory symptoms and asthma on these equations were explored. RESULTS: Spirometry tests were performed on 919 subjects from 14 to 86 years of age. Asthma decreased FVC and FEV1 in men with a R² change <1%. Respiratory symptoms decreased the FEV1/FVC ratio in both sexes. Tobacco smoking was associated with a significant reduction in FEV1 in women. CONCLUSIONS: Asthma lightly reduced lung function in males while tobacco smoking decreased FEV1, particularly in females.

  10. Manejo quirúrgico de la orbitopatía de graves

    OpenAIRE

    Rodrigo Poblete, S.

    2010-01-01

    La Enfermedad de Graves corresponde a un síndrome que comprende: bocio hipertiroídeo habitualmente, oftalmopatía asociada a la tiroides y dermatopatía. No se cuenta con estadísticas nacionales, sin embargo la mayoría de los estudios internacionales muestran una frecuencia mayor en la mujer. Desde el punto de vista del manejo quirúrgico de esta enfermedad, éste se basa en tres etapas fundamentales: descompresión orbitaria, cirugía de los músculos extraoculares y finalmente la cirugía de reposi...

  11. con mala calidad de vida

    Directory of Open Access Journals (Sweden)

    Agustín Martín-Rodríguez

    2007-01-01

    Full Text Available En este estudio ex post facto se ha analizado si los familiares de pacientes con mala calidad de vida presentan diferencias en las variables clínicas de personalidad y relaciones familiares en función de que el paciente haya estado o no ingresado en una Unidad de Cuidados Intensivos. Seleccionamos dos grupos: 29 familiares de pacientes traumatizados graves transcurridos cuatro años de su ingreso en una UCI de Traumatología y con mala calidad de vida (debido a secuelas físicas y/o psicológicas tras el ingreso, tales como traumatismos craneoencefálicos, politraumatismos y tetraplejias traumáticas y 32 familiares de pacientes con mala calidad de vida con cuatro años de evolución de su enfermedad física (hipertensión, diabetes, artritis reumatoide y síndrome de intestino irritable que no han estado ingresados en la UCI. Para alcanzar nuestro objetivo empleamos una Encuesta Psicosocial y los siguientes instrumentos: Cuestionario de Análisis Clínico, Escala de Clima Social en la Familia y Escala de Adaptación Psicosocial de la Enfermedad. Los resultados mostraron que los familiares de pacientes con mala calidad de vida que estuvieron ingresados en la UCI hace cuatro años, presentan diferencias significativas en las variables agitación y expresividad comparados con los familiares de pacientes con mala calidad de vida que no han estado ingresados en la UCI.

  12. Impacto do programa de atenção integral à criança com asma em Unidade de Saúde na Cidade de Fortaleza, Ceará

    Directory of Open Access Journals (Sweden)

    Joelma Aurélio Sousa

    2016-12-01

    Full Text Available Nas últimas décadas, a asma tornou-se um importante problema de saúde pública, visto o significativo crescimento da prevalência e da mortalidade dessa doença. Desde 1996, as entidades médicas e governamentais promoveram a criação de consensos sobre o assunto com o objetivo de programar medidas para melhorar a assistência médica e reduzir a morbimortalidade dessa enfermidade. Objetivou-se avaliar a melhora clínica dos pacientes e correlacioná-la à adesão ao tratamento medicamentoso e/ou ambiental. Foi realizado estudo documental retrospectivo descritivo analítico, com dados coletados em prontuários de pacientes que participaram do PROAICA na Unidade de Saúde Lineu Jucá, em Fortaleza-Ceará, no período de 2009 a 2014. Esses dados foram armazenados e processados usando o programa Epi Info 7.0. Observou-se melhora clínica dos pacientes após o inicio da participação no programa, assim como melhora na classificação de gravidade da asma quando se compara a primeira à ultima consulta médica. Houve aumento de 28,06% nos pacientes classificados como intermitente, redução de 20,15% dos casos persistentes leves e diminuição de 10,79% nos classificados como persistente moderado. No entanto, ocorreu um aumento de 2,88% de pacientes graves. Verificou-se melhora na classificação de controle clinico nos pacientes com classificação parcialmente controlada e não controlada. Os dados analisados mostram a importância do programa e sua colaboração para o controle da asma, facilitando a melhor visualização das dificuldades ainda encontradas em sua implementação de modo a promover possíveis mudanças para garantir um melhor atendimento e maior efetividade do PROAICA.Impact of comprehensive care program for children with asthma in Health Unit in the City of Fortaleza, CearáAbstract: Introduction: In recent decades, asthma has become an important public health problem, since the significant growth of the prevalence and

  13. Preoperative management in patients with Graves' disease.

    Science.gov (United States)

    Piantanida, Eliana

    2017-10-01

    Graves' disease is the most frequent cause of hyperthyroidism in iodine-sufficient geographical areas and is characterized by the presence in patients' serum of autoantibodies directed against the thyrotropin receptor (TRAb) that cause overproduction and release of thyroid hormones. Clinical presentation results from both hyperthyroidism and underlying autoimmunity. The diagnosis is based on characteristic clinical features and biochemical abnormalities. If serum thyrotropin (TSH) is low, serum free thyroxine (FT4) and free triiodothyronine (FT3) concentrations should be measured to distinguish between subclinical (with normal circulating thyroid hormones) and overt hyperthyroidism (with increased circulating thyroid hormones). Graves' disease is treated with any of three effective and relatively safe initial treatment options: antithyroid drugs (ATDs), radioactive iodine ablation (RAIU), and surgery. Total thyroidectomy is favored in several clinical situations, such as intolerance, ineffectiveness or recurrence after ATD treatment, radioiodine therapy contraindicated, documented or suspected thyroid malignancy, one or more large thyroid nodules, coexisting moderate-to-severe active Graves' orbitopathy, women planning a pregnancy within 6 months. Whenever surgery is selected as treatment, selection of an expert high-volume thyroid surgeons is fundamental and careful preoperative management is essential to optimize surgical outcomes. Pretreatment with ATDs in order to promptly achieve the euthyroid state is recommended to avoid the risk of precipitating thyroid storm during surgery. For the majority of patients, euthyroidism is achieved after few weeks of ATD treatment. Beta-blockers, such as propranolol, are often added effectively to control hyperthyroid symptoms. Saturated solution of potassium iodide (SSKI) or potassium iodine (Lugol's solution), given for a short period prior to surgery, in order to reduce both thyroid hormone release and thyroid gland

  14. Graves' disease. Manifestations and therapeutic options

    International Nuclear Information System (INIS)

    McFarland, K.F.; Saleeby, G.

    1988-01-01

    Graves' disease is the most common cause of hyperthyroidism. Clinical features include thyroid enlargement, eye signs, tachycardia, heat intolerance, emotional lability, weight loss, and hyperkinesis. Three modes of therapy are available. The preferences of the patient and physician are usually prime considerations in devising the therapeutic plan. Radioactive iodine is the most frequently used and safest method of treatment for adults. Antithyroid drugs are preferred for children and pregnant women. Surgery is usually reserved for patients in whom the other forms of treatment are not acceptable. Considerable patient education during the decision-making process enhances the success of the therapeutic plan

  15. Pancreatitis aguda grave asociada a gangrena vesicular

    OpenAIRE

    Arroyo-Sánchez, Abel S; Aguirre-Mejía, Rosa Y; Echenique-Martínez, Sergio E

    2014-01-01

    Se presenta el caso un paciente diabético que desarrolló un cuadro de pancreatitis aguda grave asociada a gangrena vesicular, en el que se evaluó la aplicabilidad de los criterios de clasificación y manejo de la hoja de ruta para pancreatitis aguda, así mismo se proponen algunos tópicos que pudieran ser investigados a futuro We present a diabetic patient who developed severe acute pancreatitis associated to gallbladder gangrene, in this case we assessed the applicability of classification ...

  16. Graves' disease and idiopathic intracranial hypertension

    Directory of Open Access Journals (Sweden)

    Manish Gutch

    2017-01-01

    Full Text Available Idiopathic intracranial hypertension (IIH is a central nervous system disorder characterized by raised intracranial pressure with normal cerebrospinal fluid composition and absence of any structural anomaly on neuroimaging. Among all endocrine disorders associated with the development of IIH, the association of hyperthyroidism and IIH is very rare with few cases reported till date. Thyroid disturbances have a unique association with IIH. Hypo- and hyper-thyroidism have been reported in association with this disorder. We present a rare case of a 25-year-old man with Graves' disease with intractable headache that was later investigated and attributed to development of IIH.

  17. Sepsis y nutrición artificial en pacientes graves desnutridos

    Directory of Open Access Journals (Sweden)

    Pedro Alexei Bacardí-Zapata

    2016-05-01

    Full Text Available Objetivo: Relacionar la repercusión de las sepsis con la desnutrición y el soporte nutricional en pacientes gra-ves, conforme a variables epidemiológicas de interés. Método: Se realizó una investigación aplicada y descriptiva en el período comprendido desde marzo del año 2014 hasta enero del año 2015, en el Servicio de Cuidados Intermedios del Hospital Provincial Clínicoquirúrgico Docente “Saturnino Lora Torres” de la ciudad de Santiago de Cuba. La muestra la constituyeron 32 pacientes sépticos y desnutridos a quienes se les realizó una valoración nutricional a los siete días de estadía y se les aplicó Nutrición Artificial para evaluar la interrelación entre la sepsis, desnutrición y soporte nutricional. Resultados: Predominó el grupo de edades de 65 años y más en la investigación con 15 pacientes para un 46,9%; prevaleciendo la nutrición parenteral total con 14 casos para un 43,7%. En el estudio los pacientes con sepsis graves representaron el 46,9% y dentro de este grupo la mayoría de los enfermos se encontraron desnutridos de forma severa con siete individuos. Fueron las infecciones precedentes del sistema digestivo las más frecuente con un total de 11 enfermos para un 34,4%. Conclusiones: Existe una interrelación muy potente de forma negativa para el enfermo grave entre nutrición parenteral, gra-vedad de la sepsis y severidad de la desnutrición, de tal manera que mientras más intensa sea, más perpetúa de forma negativa a la otra desencadenando finalmente una mala evolución de estos individuos que incluso los pueden llevar a la muerte. Palabras clave: cuidados intensivos; estado nutricional; pacientes internos.

  18. Prevalência e associação de asma e rinite em adolescentes de 13 e 14 anos de Fortaleza, Ceará, Brasil

    Directory of Open Access Journals (Sweden)

    Maria de Fátima Gomes de Luna

    2011-01-01

    Full Text Available Objetivou-se avaliar a prevalência e associação de asma e rinite. Trata-se de estudo transversal envolvendo 3.015 adolescentes de 13-14 anos de Fortaleza, Ceará, Brasil, de escolas públicas e privadas, utilizando-se o protocolo do International Study of Asthma and Allergies in Childhood (ISAAC, em 2006/2007. A prevalência de asma foi 22,6%; de rinite, 43,2% e de rinoconjuntivite, 18,7%, predominando no sexo feminino (p = 0,002, p < 0,001 e p < 0,001, respectivamente e nos adolescentes das escolas privadas (p < 0,001. Entre os adolescentes que relataram asma, a taxa de rinite foi de 64,4% e de rinoconjuntivite, 35,3%. A taxa da associação asma-rinite na população foi de 14,6%, e asma-rinoconjuntivite, 8%, predominando no sexo feminino (p < 0,001 e p < 0,001, respectivamente e associando-se a sibilos com limite da fala (p = 0,037 e p = 0,004, respectivamente. O estudo pode contribuir para alertar os profissionais de saúde quanto à importância da abordagem integrada dessas enfermidades, considerando o conceito da "via aérea única" e buscando opções de tratamento que atuem nas duas condições quando presentes simultaneamente.

  19. Dosimetry-based treatment for Graves' disease.

    Science.gov (United States)

    Hyer, Steve L; Pratt, Brenda; Gray, Matthew; Chittenden, Sarah; Du, Yong; Harmer, Clive L; Flux, Glenn D

    2018-06-01

    The aim of this retrospective study was to assess the long-term outcome of a personalized dosimetry approach in Graves' disease aiming to render patients euthyroid from a planned thyroid absorbed dose of 60 Gy. A total of 284 patients with Graves' disease were followed prospectively following administration of radioiodine calculated to deliver an absorbed dose of 60 Gy. Patients with cardiac disease were excluded. Outcomes were analysed at yearly intervals for up to 10 years with a median follow-up of 37.5 months. A single radioiodine administration was sufficient to render a patient either euthyroid or hypothyroid in 175 (62%) patients, the remainder requiring further radioiodine. The median radioactivity required to deliver 60 Gy was 77 MBq. Less than 2% patients required 400-600 MBq, the standard activity administered in many centres. In the cohort receiving a single administration, 38, 32 and 26% were euthyroid on no specific thyroid medication at 3, 5 and 10 years, respectively. Larger thyroid volumes were associated with the need for further therapy. The presence of nodules on ultrasonography did not adversely affect treatment outcome. A personalized dosimetric approach delayed the long-term onset of hypothyroidism in 26% of patients. This was achieved using much lower administered activities than currently recommended. Future studies will aim to identify those patients who would benefit most from this approach.

  20. Synthesis and characterization of fac-Re(CO)3-aspartic-N-monoacetic acid, a structural analogue of a potential new renal tracer, fac-99mTc(CO)3(ASMA).

    Science.gov (United States)

    Klenc, Jeffrey; Lipowska, Malgorzata; Taylor, Andrew T; Marzilli, Luigi G

    2012-09-01

    The reaction of an aminopolycarboxylate ligand, as partic- N - m onoacetic a cid (ASMA), with [Re(CO) 3 (H 2 O) 3 ] + was examined. The tridentate coordination of ASMA to this Re I tricarbonyl precursor yielded fac -Re(CO) 3 (ASMA) as a mixture of diastereomers. The chemistry is analogous to that of the Tc I tricarbonyl complex, which yields fac - 99m Tc(CO) 3 (ASMA) under similar conditions. The formation, structure, and isomerization of fac -Re(CO) 3 (ASMA) products were characterized by HPLC, 1 H NMR spectroscopy, and X-ray crystallography. The two major fac -Re(CO) 3 (ASMA) diastereomeric products each have a linear ONO coordination mode with two adjacent five-membered chelate rings, but they differ in the endo or exo orientation of the uncoordinated acetate group, in agreement with expectations based on previous studies. Conditions have been identified for the expedient isomerization of fac -Re(CO) 3 (ASMA) to a mixture consisting primarily of one major product. Because different isomeric species typically have different pharmacokinetic characteristics, these conditions may provide for the practical isolation of a single 99m Tc(CO) 3 (ASMA) species, thus allowing the isolation of the isomer that has optimal imaging and pharmacokinetic characteristics. This information will aid in the design of future 99m Tc radiopharmaceuticals.

  1. Asma na gestação: efeitos na vitalidade fetal, complicações maternas e perinatais Asthma during pregnancy: effects on fetal well-being, and maternal and perinatal complications

    Directory of Open Access Journals (Sweden)

    Renata Franco Pimentel Mendes

    2013-04-01

    Full Text Available OBJETIVO: Avaliar os efeitos da asma materna sobre a gravidez, analisando as repercussões da gravidade da doença no comprometimento do bem-estar fetal, bem como as complicações maternas e perinatais associadas. MÉTODOS: Foi realizado estudo retrospectivo de 117 gestações complicadas pela asma materna e sem outras comorbidades, no período de janeiro de 2005 a dezembro de 2010. Os critérios de inclusão foram: gestação única; diagnóstico de asma prévio à gestação; início do pré-natal antes da 28ª semana de gravidez; parto realizado na instituição; peso do recém-nascido acima de 500g e idade gestacional no parto acima de 22 semanas; ausência de malformações fetais ou anomalias cromossômicas; ausência de comorbidades maternas. A gravidade da asma foi classificada em intermitente, persistente leve, persistente moderada, persistente grave. Foram analisados os resultados do perfil biofísico fetal e da dopplervelocimetria de artéria umbilical realizados até 14 dias antes do parto. RESULTADOS: Do total de 117 gestantes asmáticas analisadas: 41 (35,0% eram intermitentes, 33 (28,2% persistentes leves, 21 (17,9% persistentes moderadas e 22 (18,8% persistentes graves. Não houve diferença significativa entre os grupos quanto ao tipo de parto: a cesárea foi realizada em 65,8% dos casos, a corticoterapia materna no momento do parto em 20,5%, a idade gestacional no parto apresentou média de 38,6 semanas (DP 1,9 semanas e o peso ao nascimento apresentou média de 3056 g (DP 581 g. O perfil biofísico fetal realizado no período anteparto (n = 90, 76,9% apresentou resultado normal (8 ou 10 em 99% dos casos. A dopplervelocimetria de artéria umbilical foi avaliada em 23,9% (n = 28 das gestantes, e apresentou-se normal em 100% dos casos. O uso de corticoterapia sistêmica foi significativamente (pOBJECTIVE: To assess the effects of maternal asthma on pregnancy, analyzing the consequences of the severity of the disease in the

  2. Thymic hyperplasia in a patient with Grave's disease.

    Science.gov (United States)

    Hamzaoui, Amira A; Klii, Rim R; Salem, Randa R; Kochtali, Ines I; Golli, Mondher M; Mahjoub, Silvia S

    2012-02-09

    Hyperplastic changes of the thymus may be found in patients with Graves' disease. However, this rarely presents as an anterior mediastinal mass, particularly among adults. In this report, we describe a 46-year old woman with Graves' disease and thymic hyperplasia.

  3. Thymic hyperplasia in a patient with Grave's disease

    Directory of Open Access Journals (Sweden)

    Hamzaoui Amira A

    2012-02-01

    Full Text Available Abstract Hyperplastic changes of the thymus may be found in patients with Graves' disease. However, this rarely presents as an anterior mediastinal mass, particularly among adults. In this report, we describe a 46-year old woman with Graves' disease and thymic hyperplasia.

  4. [Diagnostic difficulties in Grave's orbitopathy--case report].

    Science.gov (United States)

    Jedrzejowski, Maciej; Grzesiuk, Wiesław; Szwejda, Elzbieta; Bar-Andziak, Ewa

    2004-03-01

    Graves' orbitopathy is caused by intraorbital inflammatory reaction due to autoimmune thyroid disease. In most cases the diagnosis is based on the coexistence of typical eye signs and hyperthyroidism symptoms. In presented case, the absence of thyroid dysfunction implicated performance of differential diagnosis. Among many available diagnostic tools nuclear magnetic resonance seems to be the most accurate in confirmation of diagnosis of Graves' orbitopathy.

  5. Notes on Glasinac: The chronology of princely graves

    Directory of Open Access Journals (Sweden)

    Vasić Rastko

    2009-01-01

    Full Text Available Princely graves of the Iron Age represent a particular phenomenon in archaeology, which is constantly the subject of interest. They are usually dated to the end of the 6th and the beginning of the 5th century. The author discusses the chronology of princely graves in the Central Balkans and analyses their appearance in each part of this territory: on the Glasinac plateau, in Serbia, Kosovo and Metohija, Montenegro, North Albania and Nordwest Bulgaria. He concludes that they date from the middle of the 7th to the middle of the 4th century, depending on the cultural and socio-economic situation in the respective area. In the middle of the 7th century princely graves in the true sense of the word were known only on the Glasinac plateau, in the Ilijak necropolis. At the end of the 7th and in the beginning of the 6th century they still appear on Glasinac, though in greater number and in various parts of the plateau. In northwest Bulgaria a grave dating to the second half of the 7th century was found, which would, according to grave goods, correspond to the Glasinac princely graves. On the other hand, there are no princely graves in Serbia and north Albania from that time but some outstanding warrior graves are known, belonging possibly to the chiefs of smaller warlike bands, whose power was limited. Princely graves from Arareva gromila on Glasinac, Pilatovići by Požega and Lisijevo Polje by Berane date to the beginning of the second half of the 6th century, and according to their characteristics represent princes, whose power and wealth were considerable and known to the neighbours. Culmination of the rise of the princes in this region was demonstrated by the graves from Novi Pazar, Atenica, and Pećka banja, which date to the end of the 6th and the first quarter of the 5th century. Some decades later there are several rich graves, e.g. the recently discovered grave from Velika Krsna, which could belong to a prince, but can not be compared with the

  6. The 2016 European Thyroid Association/European Group on Graves' Orbitopathy Guidelines for the Management of Graves' Orbitopathy

    NARCIS (Netherlands)

    Bartalena, Luigi; Baldeschi, Lelio; Boboridis, Kostas; Eckstein, Anja; Kahaly, George J.; Marcocci, Claudio; Perros, Petros; Salvi, Mario; Wiersinga, Wilmar M.; Adamidou, Fotini; Anagnostis, Panagiotis; Ayvaz, Goksun; Azzolini, Claudio; Boschi, Antonella; Bournaud, Claire; Clarke, Lucy; Currò, Nicola; Daumerie, Chantal; Dayan, Colin; Fuhrer, Dagmar; Konuk, Onur; Marinò, Michele; Morris, Daniel; Nardi, Marco; Pearce, Simon; Pitz, Susanne; Rudovsky, Gottfried; Vannucchi, Guia; Vardanian, Christine; von Arx, Georg

    2016-01-01

    Graves' orbitopathy (GO) is the main extrathyroidal manifestation of Graves' disease, though severe forms are rare. Management of GO is often suboptimal, largely because available treatments do not target pathogenic mech anisms of the disease. Treatment should rely on a thorough assessment of the

  7. Predictive score for the development or progression of Graves' orbitopathy in patients with newly diagnosed Graves' hyperthyroidism

    DEFF Research Database (Denmark)

    Wiersinga, Wilmar; Žarković, Miloš; Bartalena, Luigi

    2018-01-01

    OBJECTIVE: To construct a predictive score for the development or progression of Graves' orbitopathy (GO) in Graves' hyperthyroidism (GH). DESIGN: Prospective observational study in patients with newly diagnosed GH, treated with antithyroid drugs (ATD) for 18 months at ten participating centers f...

  8. Outcome of very long-term treatment with antithyroid drugs in Graves' hyperthyroidism associated with Graves' orbitopathy

    NARCIS (Netherlands)

    Elbers, Laura; Mourits, Maarten; Wiersinga, Wilmar

    2011-01-01

    It is still debated which treatment modality for Graves' hyperthyroidism (GH) is most appropriate when Graves' orbitopathy (GO) is present. The preference in our center has been always to continue antithyroid drugs for GH (as the block-and-replace [B-R] regimen) until all medical and/or surgical

  9. Graves' ophthalmopathy and 131I therapy

    International Nuclear Information System (INIS)

    Marcocci, C.; Bartalena, L.; Tanda, M.L.; Manetti, L.; Dell'Unto, E.; Mazzi, B.; Rocchi, R.; Barbesino, G.; Pinchera, A.

    1999-01-01

    Graves' ophthalmopathy is an autoimmune process initiated and maintained by antigen(s) shared by the thyroid and the orbit. A matter of argument concerns the choice of the method of treatment for Graves' hyperthyroidism when clinically evident ophthalmopathy is present. Restoration of euthyroidism appears to be beneficial for ophthalmopathy. On the other hand the continuing disease activity associated with the recurrence of hyperthyroidism appears to adversely affect the course of ophthalmopathy. For these reasons it is our opinion that in patients with Graves' hyperthyroidism and ophthalmopathy the permanent control of thyroid hyper function by ablation of thyroid tissue should be obtained by radioiodine therapy or thyroidectomy. The rationale for an ablative strategy is the following: i) permanent control of hyperthyroidism avoids exacerbations of eye disease associated with recurrence of hyperthyroidism; i i) hypothyroidism, which follows thyroid tissue ablation, should be regarded as a therapeutic end point rather than as an undesirable result; iii) ablation of thyroid tissue may result in the removal of both the thyroid-orbit cross-reacting antigen(s) and the major source of thyroid-auto reactive lymphocytes. The relationship between radioiodine therapy and the course of GO is a matter of controversy, and some authors have suggested that radioiodine administration ma be associated with a worsening of preexisting ophthalmopathy. This was not observed when radioiodine treatment was associated with a 3-month oral course of prednisone. The development or progression of GO after radioiodine therapy might be due to the release of thyroid antigens following radiation injury and to subsequent exacerbations of autoimmune reactions directed towards antigens shared by the thyroid and the orbit. The view that radioiodine therapy may be associated with a progression of ophthalmopathy is not shared by some authors who claim that the apparent link between progression of

  10. Enfermedad de Graves y cáncer de tiroides. Reporte de caso.

    OpenAIRE

    Manrique-Hurtado, Helard; Pinto-Valdivia, Miguel; Acosta-Chacaltana, Max

    2011-01-01

    Se reporta el caso de una mujer de 62 años con antecedente de cáncer de recto curado, con Enfermedad de Graves de reciente diagnóstico. El examen físico mostró un bocio difuso y presencia de un nódulo en el polo inferior del lóbulo derecho. El perfil tiroideo mostró un TSH suprimido y hormonas tiroideas aumentadas. Los anticuerpos antitiroideos fueron negativos. La ecografía de tiroides confirmó la presencia de un nódulo sólido en la tiroides y ganglios linfáticos aumentados de tamaño. La gam...

  11. Sintomas e fatores de risco para asma entre escolares piauienses Síntomas y factores de riesgo para el asma entre escolares piauienses Symptoms and risk factors for asthma among piauiense schoolchildren

    OpenAIRE

    Gessianne Carvalho Castro; Lívia Kênia de Carvalho Sousa; Paula Valentina de Sousa Vera; Luisa Helena de Oliveira Lima; Edina Araújo Rodrigues Oliveira; Rúbia Fernanda Santos Lima; Luis Fernando Beserra Magalhães; Nileide Lima Araújo; Marcos Venícios de Oliveira Lopes

    2012-01-01

    OBJETIVOS: Analisar a prevalência de sintomas de asma entre escolares de seis a sete anos do município de Picos-PI; e identificar fatores de risco associados à doença. MÉTODOS: Estudo transversal realizado com crianças de 6 e 7 anos de Picos em novembro de 2010 a maio de 2011. Para coletar os dados, foi utilizado um formulário adaptado do Internacional Study of Asthma and Allergies in Childhood. Os dados foram analisados com base na estatística descritiva e analítica. RESULTADOS: Dentre as 23...

  12. Cambios en la etiología, resultados y características de los pacientes con hemorragia digestiva aguda grave a lo largo del periodo 1999-2005 Changes in the etiology, outcome, and characteristics of patients with acute gastrointestinal bleeding between 1999 and 2005

    Directory of Open Access Journals (Sweden)

    A. Garrido

    2007-05-01

    Full Text Available Objetivos: analizar la evolución, a lo largo del periodo 1999-2005, de las siguientes variables de los pacientes ingresados por hemorragia digestiva (HD en una Unidad de Sangrantes: etiología, patología de base, consumo de AINE/anticoagulación y mortalidad. Material y métodos: durante el periodo 1999-2005 se ha estudiado la evolución de las siguientes causas de HD que requirieron ingreso en la Unidad de Sangrantes: ulcus duodenal (UD, ulcus gástrico (UG, hipertensión portal (HPT y otros. De igual forma se ha analizado la evolución en el porcentaje de enfermos ingresados con patología de base, consumo de fármacos AINE/anticoagulantes y mortalidad. Resultados: se han incluido 1.611 pacientes en el estudio con una edad media de 60,45 años (59,7-61,2, 76,41% hombres (74,3-78,5. La UD fue responsable del 22,20% de episodios (20,2-24,3, la UG del 18,40% (16,6-20,4 y la HPT del 33,60% (31,3-36,0. De forma global realizaban tratamiento con AINE el 34,5% (32,6-37,3, anticoagulación el 7,1% (6,0-8,6, presentaban patología de base el 72,6% (70,4-74,8 y la mortalidad global fue del 6,27% (5,16-7,59. A lo largo del periodo estudiado se constató un aumento de los pacientes con patología de base (p Objectives: to analyze the evolution of the following variables in patients admitted to a Blood Unit for gastrointestinal bleeding throughout 1999-2005: etiology, comorbid diseases, use of NSAIDs/anticoagulants, and mortality. Material and methods: we analyzed the evolution of the following causes of GIB that required admission to the Blood Unit from 1999 to 2005: duodenal ulcer (DU, gastric ulcer (GU, portal hypertension (PHT, and others. We also analyzed changes in the percentage of patients admitted with comorbid disease, use of NSAIDs/anticoagulants, and mortality. Results: 1,611 patients with a mean age of 60.45 years (59.7-61.2 were included in this study; 76.41% were males (74.3-78.5. DU was the cause of bleeding in 22.20% of cases (20

  13. Management of Graves' hyperthyroidism

    Energy Technology Data Exchange (ETDEWEB)

    Orgiazzi, J.

    1987-06-01

    Management of Graves' disease hyperthyroidism, a life-long disease, hinges on a clear strategy and involves the patient's understanding and adherence. Antithyroid drug treatment is difficult to adapt to each patient's need; so far, the more efficient use of antithyroid drug remains on long-term courses of 18 months or more. Although a picture is evolving of patients more likely to go into remission after the medical treatment, its characteristics are not yet reliable. Radical (ablative) treatments are often necessary. In general, surgery might appear less appealing than /sup 131/I irradiation which, as compared to surgery, carries only the risk of later hypothyroidism. It is hoped that basic as well as clinical research is able to generate innovative, better adapted, and pathophysiologically oriented new therapeutic means. 124 references.

  14. Radiation therapy of Graves' ophthalmopathy

    Energy Technology Data Exchange (ETDEWEB)

    Kawamura, Toshiki; Koga, Sukehiko; Anno, Hirofumi; Komai, Satoshi (Fujita-Gakuen Health Univ., Toyoake, Aichi (Japan))

    1992-01-01

    During the decade from 1978 to 1987, 20 patients with Graves' ophthalmopathy were treated with irradiation of 2000 cGy to the orbital tissue. We examined the effects of the therapy on 17 such patients. Exophthalmos tended to decrease. When the degree of deviation of the exophthalmic eye was small, the effect of therapy tended to be better than when it was large. Two cases that showed an increase in retrobulbar fatty tissue without thickening of the extraocular muscles did not respond as well as those that had thickening of the extraocular muscles. Diplopia tended to improve both subjectively and objectively. Ocular movement improved in 11 of the 17 patients. There were no serious radiation injuries after the radiation therapy, except for some transient swelling of the eyelid. (author).

  15. Pathogenesis of Graves' disease and therapeutic implications

    International Nuclear Information System (INIS)

    Seif, F.J.

    1997-01-01

    Graves' disease presents itself clinically mainly as hyperthyroidism and infiltrative ophthalmopathy and to a minimal extent also as dermopathy and acropachy. Autoimmune processes are the basic pathogenesis. Stimulating antibodies against the TSH receptor cause hyperthyroidism. Autoantibodies and autoreactive T lymphocytes against primarily thyroidal antigens cross-react with similar antigens of the eye muscles and orbital connective tissue, thus spreading the disease from the thyroid to the eyes. The therapeutic goal comprises not only the treatment of hyperthyroidism, but also the induction of a steady immuntolerance in order to minimize the irreversible damage to the eye. The therapeutic armamentarium is formed by antithyroid drugs, glucocorticoids, retrobulbar radition and thyroid ablation, either by nearly total thyroidectomy or by radioiodine. The different indications for both ablative procedures are discussed. (orig.) [de

  16. SÍNDROMES HIPERTENSIVAS GRAVES – ESTUDO DESCRITIVO COM ADOLESCENTES ATENDIDAS EM MATERNIDADE ESCOLA

    Directory of Open Access Journals (Sweden)

    Andreia Gregório Lima

    2012-01-01

    Full Text Available Estudio exploratorio y descriptivo, con objetivo de analizar los datos clínicos y obstétricos relacionados a síndromes hipertensivos graves en adolescentes asistidas en maternidad escuela de Recife-PE, Brasil. La población fue de 186 adolescentes embarazadas con preeclampsia severa y/o eclampsia entre 2003 y 2008. La edad varió entre 15 y 19 años, eran negras, solteras y con baja escolaridad. La mayoría era primíparas, pero la recurrencia del embarazo fue de 16% de los casos. Realizaran seis o más consultas de prenatal, el embarazo avanzó a término y el tipo de parto más frecuente fue la cesárea. Las comorbidades identificadas fueron alteraciones de volumen del líquido amniótico, cuadros hemorrágicos e infecciosos. Fueron identificados también casos de retraso del crecimiento intrauterino, prematuridad, ictericia, hipoxia y bajo peso al nacer. El embarazo en la adolescencia asociado con los síndromes hipertensivos severos posee relación con complicaciones maternas, fetales y neonatales.

  17. Supervoltage orbital radiotherapy for progressive Graves' ophthalmopathy

    International Nuclear Information System (INIS)

    Kriss, J.P.; McDougall, I.R.; Petersen, I.A.; Donaldson, S.S.

    1989-01-01

    Since 1968 we have employed supervoltage orbital radiation as treatment for severe progressive Graves' ophthalmopathy. A numerical ophthalmic index was used to asess pre- and post-treatment serverity. In the past 20 years we have treated 311 patients of whom 275 have been followed for ≤ 1 year or until any eye surgery was performed. An orbital radiation dosage of 2000 rads in 2 weeks was used for the majority of patients (Series I and III). Series II patients received an orbital dose of 3000 rads in 3 weeks. Demographic differences were observed between these series, thus mandating presentation of the results of each separately. Analyses excluded any result achieved by any post-radiation surgical procedure on the eyes. Post-theraphy worsening of ophtalmopathy occurred in only 29 of 1025 observations. Improvement or complete resolution was observed within each category of eye involvement, but lack of favorable response was also recorded in significant numbers. Improvement in proptosis occurred with the lowest frequency and magnitude. About 30% of the patients required eye muscle surgery to correct residual diplopia. Analysis of the data by step-wise linear regression analysis enabled us a. to derive formulae predicting the problable response to radiation therapy according to sign and severity, and b. identify parameters which diminished the likelihood or the extent of a favorable response. The latter included male sex, never thyrotoxic, age greater than 60 years, and requirement for concomitant treatment for hyperthyroidism. No long-term adverse reactions attributable to the radiotherapy have been observed. We conclude that supervoltage orbital radiotherapy, combined with later eye muscle surgery if necessary, is an effective treatment strategy for progressive Graves' ophthalmopathy. (author)

  18. Radiotherapy in the management of Graves' ophthalmopathy

    International Nuclear Information System (INIS)

    Sakata, Koh-ichi; Hareyama, Masato; Oouchi, Atsushi; Shidou, Mitsuo; Nagakura, Hisayasu; Morita, Kazuo; Osanai, Hajime; Ohtsuka, Kenji; Hinoda, Yuji

    1998-01-01

    To report the results of radiotherapy for patients with failure, adverse reactions or relative contraindications to the use of steroids or immunosuppressants, by using newly developed quantitative indexes. Fourteen female and six male patients with Graves' ophthalmopathy were treated with radiotherapy between 1989 and 1996. Prior to radiotherapy, eight patients received treatment with prednisone, four received immunosuppressants and four received a combination of both. Four patients with contraindications to steroids were initially managed with radiotherapy. Most of the patients received a dose of 24-28 Gy in 2 Gy fractions. We used the newly developed motility limitation index to assess extraocular motility. Treatment was well tolerated. There have been no late complications. All 12 patients with soft tissue signs such as edema, irritation, tearing and pain were improved. Proptosis did not improve or improved only slightly, 3 mm at best. However, proptosis in all but two has been stabilized and has not deteriorated in the follow-up period. Most of the patients have experienced an improvement of eye-muscle motility. Extraocular muscles that work for elevation were impaired more severely than the other muscles and this tended to remain. Of the 16 patients using steroids before or when radiotherapy was initiated, 15 were tapered off and only one patient required additional steroids, thus sparing the majority from steroid adverse reactions. Radiotherapy was effective in preventing exacerbations of active inflammatory ophthalmopathy in patients with Graves' disease with minimal morbidity and thus eliminated the adverse reactions associated with protracted corticosteroid use. The newly developed motility limitation index was useful in detecting delicate changes in motility of individual extraocular muscles. (author)

  19. Componentes C3 e C4 do sistema complemento como biomarcadores no diagnóstico de asma atópica intermitente

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    Tainá Mosca

    2011-12-01

    Full Text Available OBJETIVO: Analisar os componentes séricos C3 e C4 do sistema complemento como possíveis biomarcadores de asma atópica intermitente. MÉTODOS: Determinação dos níveis séricos dos componentes C3 e C4 do complemento em 70 crianças com história de "chiado no peito” entre 3 e 14 anos. Após 2 anos de acompanhamento ambulatorial, seguindo-se critérios de inclusão e exclusão, as crianças foram divididas em 2 grupos: 40 crianças com asma atópica intermitente e 30 crianças sem asma. Não houve uso de corticosteroides inalatórios ou sistêmicos ou de broncodilatadores de ação prolongada em nenhum dos grupos. Os dois grupos apresentaram faixas etárias semelhantes, comparadas pelo teste t de Student. Os resultados dos componentes C3 e C4 mostraram distribuição normal e foram então comparados utilizando-se o teste t de Student, considerando-se significante quando p < 0,05. RESULTADOS: Os valores observados no grupo de crianças portadoras de asma atópica intermitente mostraram aumentos significativos para: C3 em 85,0% das crianças; C4 em 87,5%; C3 e C4 em 72,5%; C3 ou C4 em 97,5%, quando comparados aos valores observados das crianças sem asma e da mesma faixa etária. CONCLUSÃO: Observamos um aumento dos valores séricos dos componentes C3 e/ou C4 do sistema complemento na maioria das crianças estudadas portadoras de asma atópica intermitente, em comparação aos valores de crianças sem asma, da mesma faixa etária. Concluímos que a presença de valores aumentados dos componentes C3 e/ou C4 do complemento possa representar um biomarcador no diagnóstico de asma atópica intermitente.

  20. Produtos naturais utilizados para tratamento de asma em crianças residentes na cidade de Salvador-BA, Brasil

    Directory of Open Access Journals (Sweden)

    Ryan dos S. Costa

    Full Text Available O conhecimento popular é o passo inicial para a investigação científica de atividades terapêuticas de remédios caseiros. Diversas patologias podem ser tratadas ou amenizadas através de preparações de origem natural e muitos fármacos disponíveis são oriundos de fontes naturais. Este trabalho tem como objetivo avaliar o uso de remédios caseiros derivados de plantas para tratamento de asma em crianças residentes no município de Salvador. Os dados foram obtidos a partir de estudo realizado em Salvador sobre fatores de risco, uso de medicações e vias imunológicas relacionadas à asma em crianças. Foram calculadas as freqüências de uso de preparações caseiras para tratamento de asma por esta população e realizado uma revisão bibliográfica sobre os efeitos das plantas mais usadas. Dentre as espécies mais citadas, destacam-se o Allium sativum (alho que teve a maior freqüência de utilização na preparação dos remédios caseiros (25%, seguido da Allium cepa (cebola, 19,74%. Após a revisão crítica de literatura, constatou-se que a maioria das espécies é utilizada com base em relatos fundamentados no saber popular, sendo assim carente de evidências científicas para as atividades farmacoterapêuticas esperadas. Neste sentido, há necessidade de mais estudos farmacológicos para comprovação das atividades terapêuticas peculiares a cada produto de origem natural bem como para avaliar possíveis efeitos tóxicos destes produtos.

  1. Graves' Disease that Developed Shortly after Surgery for Thyroid Cancer.

    Science.gov (United States)

    Yu, Hea Min; Park, Soon Hyun; Lee, Jae Min; Park, Kang Seo

    2013-09-01

    Graves' disease is an autoimmune disorder that may present with various clinical manifestations of hyperthyroidism. Patients with Graves' disease have a greater number of thyroid nodules and a higher incidence of thyroid cancer compared with patients with normal thyroid activity. However, cases in which patients are diagnosed with recurrence of Graves' disease shortly after partial thyroidectomy for thyroid cancer are very rare. Here we report a case of hyperthyroid Graves' disease that occurred after partial thyroidectomy for papillary thyroid cancer. In this case, the patient developed hyperthyroidism 9 months after right hemithyroidectomy, and antithyroglobulin autoantibody and thyroid stimulating hormone receptor stimulating autoantibody were positive. Therefore, we diagnosed Graves' disease on the basis of the laboratory test results and thyroid ultrasonography findings. The patient was treated with and maintained on antithyroid drugs. The mechanism of the recurrence of Graves' disease in this patient is still unclear. The mechanism may have been the improper response of the immune system after partial thyroidectomy. To precisely determine the mechanisms in Graves' disease after partial thyroidectomy, further studies based on a greater number of cases are needed.

  2. Predictive factors of thyroid cancer in patients with Graves' disease.

    Science.gov (United States)

    Ren, Meng; Wu, Mu Chao; Shang, Chang Zhen; Wang, Xiao Yi; Zhang, Jing Lu; Cheng, Hua; Xu, Ming Tong; Yan, Li

    2014-01-01

    The best preoperative examination in Graves' disease with thyroid cancer still remains uncertain. The objectives of the present study were to investigate the prevalence of thyroid cancer in Graves' disease patients, and to identify the predictive factors and ultrasonographic features of thyroid cancer that may aid the preoperative diagnosis in Graves' disease. This retrospective study included 423 patients with Graves' disease who underwent surgical treatment from 2002 to 2012 at our institution. The clinical features and ultrasonographic findings of thyroid nodules were recorded. The diagnosis of thyroid cancer was determined according to the pathological results. Thyroid cancer was discovered in 58 of the 423 (13.7 %) surgically treated Graves' disease patients; 46 of those 58 patients had thyroid nodules, and the other 12 patients were diagnosed with incidentally discovered thyroid carcinomas without thyroid nodules. Among the 58 patients with thyroid cancer, papillary microcarcinomas were discovered in 50 patients, and multifocality and lymph node involvement were detected in the other 8 patients. Multivariate regression analysis showed younger age was the only significant factor predictive of metastatic thyroid cancer. Ultrasonographic findings of calcification and intranodular blood flow in thyroid nodules indicate that they are more likely to harbor thyroid cancers. Because the influencing factor of metastatic thyroid cancers in Graves' disease is young age, every suspicious nodule in Graves' disease patients should be evaluated and treated carefully, especially in younger patients because of the potential for metastasis.

  3. Graves' Disease that Developed Shortly after Surgery for Thyroid Cancer

    Directory of Open Access Journals (Sweden)

    Hea Min Yu

    2013-09-01

    Full Text Available Graves' disease is an autoimmune disorder that may present with various clinical manifestations of hyperthyroidism. Patients with Graves' disease have a greater number of thyroid nodules and a higher incidence of thyroid cancer compared with patients with normal thyroid activity. However, cases in which patients are diagnosed with recurrence of Graves' disease shortly after partial thyroidectomy for thyroid cancer are very rare. Here we report a case of hyperthyroid Graves' disease that occurred after partial thyroidectomy for papillary thyroid cancer. In this case, the patient developed hyperthyroidism 9 months after right hemithyroidectomy, and antithyroglobulin autoantibody and thyroid stimulating hormone receptor stimulating autoantibody were positive. Therefore, we diagnosed Graves' disease on the basis of the laboratory test results and thyroid ultrasonography findings. The patient was treated with and maintained on antithyroid drugs. The mechanism of the recurrence of Graves' disease in this patient is still unclear. The mechanism may have been the improper response of the immune system after partial thyroidectomy. To precisely determine the mechanisms in Graves' disease after partial thyroidectomy, further studies based on a greater number of cases are needed.

  4. Psychiatric manifestations of Graves' hyperthyroidism: pathophysiology and treatment options.

    Science.gov (United States)

    Bunevicius, Robertas; Prange, Arthur J

    2006-01-01

    Graves' disease is an autoimmune disorder that is the most common cause of hyperthyroidism. Other symptoms associated with the disease are goitre, ophthalmopathy, and psychiatric manifestations such as mood and anxiety disorders and, sometimes, cognitive dysfunction. Graves' hyperthyroidism may result in these latter manifestations via the induction of hyperactivity of the adrenergic nervous system. This review addresses the psychiatric presentations, and their pathophysiology and treatment, in patients with hyperthyroidism, based on literature identified by a PubMed/MEDLINE database search. Although the focus is on mental symptoms associated with Graves' disease, it is not always clear from the literature whether patients had Graves' disease: in some studies, the patients were thought to have Graves' disease based on clinical findings such as diffuse goitre or ophthalmopathy or on measurements of thyroid antibodies in serum; however, in other studies, no distinction was made between Graves' hyperthyroidism and hyperthyroidism from other causes. Antithyroid drugs combined with beta-adrenoceptor antagonists are the treatments of choice for hyperthyroidism, as well as for the psychiatric disorders and mental symptoms caused by hyperthyroidism. A substantial proportion of patients have an altered mental state even after successful treatment of hyperthyroidism, suggesting that mechanisms other than hyperthyroidism, including the Graves' autoimmune process per se and ophthalmopathy, may also be involved. When psychiatric disorders remain after restoration of euthyroidism and after treatment with beta-adrenoceptor antagonists, specific treatment for the psychiatric symptoms, especially psychotropic drugs, may be needed.

  5. Sistema predictiu per a evolució de pacients. Aplicació al cas d'asma infantil

    OpenAIRE

    Rubia Galera, Ivan de La

    2015-01-01

    [CATALÀ] S'ha dissenyat una aplicació que permet treballar amb dades de pacients i episodis, preprocessar-les i entrenar models amb algorismes d'aprenentatge automàtic que ofereixen bons resultats. S'ha experimentat amb dades de pacients d'asma infantil de l'hospital de Sant Joan de Déu. [ANGLÈS] We've developed an application that can deal with patient data, preprocess it and train models with machine learning algorithms that have given good results. We've experimented with data from Hosp...

  6. Conceitos de asma e instrumentos de levantamentos epidemiológicos de prevalência

    Directory of Open Access Journals (Sweden)

    M.M. Vasconcelos

    2004-07-01

    Full Text Available RESUMO: A asma, doença multifactorial, de alta prevalência, com recorrência frequente, acomete indivíduos independentemente de idade, sexo e área geográfica. Por não haver consenso quanto à sua definição, diversos questionários foram desenvolvidos para padronização dos critérios epidemiológicos de suspeição ou diagnóstico, entre eles o da Comunidade Europeia de Saúde Respiratória (European Community Respiratory Health Survey - ECRHS, ferramenta importante para o estudo da prevalência em adultos com idade entre 20 e 44 anos, conferindo melhoria da qualidade metodológica dos levantamentos epidemiológicos, tornando-os comparáveis em tempo e local. Os objectivos deste artigo são comentar a evolução do conceito de asma e suas repercussões sobre os levantamentos epidemiológicos, historiar os instrumentos utilizados nesses levantamentos, relevando a importância do ECRHS, e apresentar dados epidemiológicos de asma em 351 trabalhadores de hospital-escola, na cidade de Recife – Pernambuco - Brasil.REV PORT PNEUMOL 2004; X (4: 319-329 ABSTRACT: Introduction: Asthma, as a multifatorial disease, with high prevalence and frequent recurrence, attack people, independently of age, sex and geographical area. Because of lack of consensus about the definition of asthma, many questionnaires have been developed to standardize epidemiological criteria of suspicion and diagnosis. Among them, the European Community Respiratory Health Survey (ECRHS is an important tool for prevalence studies on adults aged from 20 to 44 years old, that represented a methodological improvement of epidemiological surveys, turning them comparable about time and place. The objectives of this article are to comment the evolution of asthma concepts and its repercussion on epidemiological surveys, as well as to chronicle the tools used on these surveys, emphasizing the importance of ECRHS and

  7. Instrumentos específicos para avaliar a qualidade de vida em crianças e adolescentes com asma

    OpenAIRE

    Cristian Roncada; Rita Mattiello; Paulo M. Pitrez; Edgar E. Sarria

    2013-01-01

    OBJETIVO: Identificar e descrever os instrumentos específicos que avaliam a QVRS de crianças e adolescentes com asma. FONTES DOS DADOS: Realizamos buscas nas bases de dados PubMed, Ovid e LILACS utilizando várias combinações de descritores (MeSH terms), selecionando artigos originais sobre desenvolvimento de questionários específicos de QVRS, publicados em inglês, português ou espanhol, entre 1990 e 2012. SÍNTESE DOS DADOS: Foram identificados 15 instrumentos que preencheram os critérios de i...

  8. Intoxicaciones agudas graves en un servicio de medicina intensiva durante doce años

    Directory of Open Access Journals (Sweden)

    Palazón Sánchez C

    2000-01-01

    Full Text Available Fundamento: Conocer la epidemiología de las intoxicaciones agudas graves en un servicio de medicina intensiva y evaluar el pronóstico de la PCR y mortalidad asociada a los distintos tóxicos Métodos: Estudio retrospectivo realizado en el servicio de medicina intensiva polivalente de 10 camas, ubicado en un Hospital General de adultos. Período de estudio 12 años. Revisión de las historias clínicas de las personas ingresadas en el servicio de medicina intensiva por intoxicaciones agudas graves. Se recogieron datos demográficos, existencia de PCR al ingreso, necesidad de VM, complicaciones de las intoxicaciones agudas graves y mortalidad de la serie. Se realizó un análisis global y por año de estudio. El tratamiento estadístico de los datos se realizó con el paquete SPSS mediante la "t" de Student o la "chi" cuadrado, considerando valores significativos si p<0,05 Resultados: Se han incluido 233 sujetos, de los que 130 fueron varones. La estancia media fue de 4 días. El 63% de los pacientes fueron menores de 40 años (p<0,05. La intoxicación más frecuente fue la medicamentosa debida a un solo producto (72%. La supervivencia tras la PCR fue del 40% (4/10. La mortalidad global se situó en el 5,6% (n=13, habiendo precisado el 92% de los sujetos que posteriormente murieron, VM en algún momento de su ingreso en la unidad de cuidados intensivos. Conclusiones: En nuestro medio, la intoxicación más frecuente es la medicamentosa. La mortalidad se muestra dependiente del carácter de voluntariedad, pero independiente del tipo de tóxico (medicamentoso o no. La PCR asociada a las intoxicaciones agudas graves tiene, en nuestra serie, un mejor pronostico que la asociada a otras patologías. La VM asociada a las intoxicaciones agudas graves tiene una mortalidad baja (15,7%

  9. Thyroid carcinoma in Graves' disease: A meta-analysis.

    Science.gov (United States)

    Staniforth, Joy U L; Erdirimanne, Senarath; Eslick, Guy D

    2016-03-01

    The incidence of thyroid carcinoma is increasing worldwide. Graves' disease is the most common hyperthyroid disease. Studies have suggested an increased risk of thyroid malignancy in Graves' disease: there has not yet been a meta-analysis to allow quantitative comparison. The purpose of this study was to determine the risk of thyroid carcinoma in Graves' disease, and to gather information on the histological subtypes of carcinoma and the co-existence of thyroid nodules. Several databases and article reference lists were searched. Inclusion criteria included appropriate diagnostic criteria for thyroid conditions and a diagnoses of carcinoma based on histology. 33 studies were selected, all reporting on surgically-resected specimens. The event rate of thyroid carcinoma in Graves' disease was 0.07 (95% CI 0.04 to 0.12). There was no data to allow comparison with patients without hyperthyroid diseases. There was no increase in the odds of developing carcinoma in Graves' disease compared to toxic multinodular goitre and toxic uninodular goitre. 88% of thyroid carcinomas in Graves' disease were papillary, with solitary papillary micro-carcinoma (diameter 10 mm or less) comprising 23% of all detected thyroid carcinomas. Patients with Graves' disease and co-existing thyroid nodules were almost 5 times more likely to be diagnosed with thyroid carcinoma than those without nodules. Thyroid malignancy in Graves' disease requiring surgical treatment should be considered as likely as in other hyperthyroid diseases needing surgical treatment. Clinicians should consider screening selected patients with Graves' disease for nodules whilst being aware of potentially over-diagnosing papillary micro-carcinoma. Crown Copyright © 2015. Published by Elsevier Ltd. All rights reserved.

  10. Death by Suicide in Graves' Disease and Graves' Orbitopathy: A Nationwide Danish Register Study.

    Science.gov (United States)

    Ferløv-Schwensen, Charlotte; Brix, Thomas Heiberg; Hegedüs, Laszlo

    2017-12-01

    Graves' disease (GD) is associated with excess morbidity and mortality, but little is known about unnatural manners of death and the potential relation with Graves' orbitopathy (GO). This study investigated the risk of unnatural death in Graves' patients with and without orbitopathy compared to matched control populations. This was a cohort study covering all adult Danes (≥18 years) diagnosed with GD or GO during 1995-2012. Median follow-up time was 7.9 years (range 0-17.5 years). Utilizing the Danish Register of Causes of Death and the Danish National Patient Registry, 28,461 subjects with GD and 3965 with GO were identified and matched for age and sex with four subjects from the background population. The manner of death was identified, and hazard ratios (HR) for mortality due to unnatural deaths (accident, suicide, violence/homicide, and unknown) were calculated using Cox regression analyses, adjusted for pre-existing somatic and psychiatric morbidity. In Graves' disease overall (GD + GO), there was an increased risk of death from unknown unnatural manners (HR = 2.01 [confidence interval (CI) 1.17-3.45], p = 0.012) and of suicide, although the latter difference was not with certainty statistically significant (HR = 1.43 [CI 1.00-2.04], p = 0.053). There was no significant difference in risk of death from suicide in GD subjects compared to their controls (HR = 1.27 [CI 0.85-1.89], p = 0.253). However, GO patients had a significantly higher risk of death from suicide (HR = 2.71 [CI 1.16-6.32], p = 0.022). Mortality by suicide was increased in Graves' disease overall, most significantly in patients with GO, also after adjustment for pre-existing somatic and psychiatric disease. These findings indicate that GD and GO may have a significant role in the pathophysiological mechanisms of suicidal behavior. Beyond independent confirmation, reasons for this need to be explored in order to introduce preventive measures.

  11. Concomitant Graves' disease and Hashimoto's thyroiditis, presenting as primary hypothyroidism.

    LENUS (Irish Health Repository)

    Cronin, C C

    2012-02-03

    Hypothyroidism in patients with Graves\\' disease is usually the result of ablative treatment. We describe a 58 year old man with Graves\\' ophthalmopathy and pre-tibial myxoedema, who presented with spontaneous primary hypothyroidism. Circulating TSH receptor antibody activity was increased, while thyroid microsomal antibody was detectable in titres greater than one in one hundred thousand. It is likely that the TSH receptor antibody of Graves\\' disease was ineffective in stimulating hyperthyroidism because of concomitant thyroid destruction due to Hashimoto\\'s disease. Alternatively, primary hypothyroidism could have resulted from the effects of a circulating TSH receptor blocking antibody.

  12. Standardization of 131I therapy for Graves disease

    International Nuclear Information System (INIS)

    Tang Jianlin; Li Yuying; Gao Liuyan; Tang Xiuping; Hu Hongyong

    2011-01-01

    Objective: To establish the normative and standard measures, to ensure medical safety and quality of care of the patients with Graves disease treated by 131 I therapy. Methods: Formulating and strictly implementing the medical organizational and technical measures of 131 I therapy for Graves disease and regular follow-up. Results: Receiving 131 I treatment of 104 patients, follow-up 6-36 months, no adverse events, the cure rate of 59.6%, the efficient rate is 99.9%. Conclusion: It is important guarantee for the medical quality and safety to standardize the 131 I therapy of Graves disease. (authors)

  13. Graves' disease with special reference to radiation therapy

    International Nuclear Information System (INIS)

    Seegenschmidt, M. H.; Heyd, R.; Esser, J.; Mould, R.F.

    2006-01-01

    Graves' disease, although not malignant, nevertheless can lead to serious events such as permanent loss of vision if it remains untreated. This review article describes the clinical symptoms of the disease, includes a commentary on the Graves' disease subgroup of thyroid-associated orbitipathy (TAO), and defines clinical activity scoring systems which grade the severity of the disease in patients (clinical activity, NOSPECS and LEMO scoring ). An review of radiotherapy in the 1980s is followed by a summary of the 2003 German national survey on radiotherapy for Graves' disease. Radiation therapy technique is then described and discussed. Case histories are from the Alfred Krupp Hospital in Essen. (author)

  14. Immunoreactive 'TSH' in urinary concentrates of Graves' disease patients

    International Nuclear Information System (INIS)

    Van Herle, A.; Orgiazzi, J.; Greipel, M.A.; Slucher, J.A.; Honbo, K.S.; Hopital de l'Antiquaille, 69 - Lyon

    1978-01-01

    A double antibody radioimmunoassay was used to analyse immunoreactive thyrotrophin in urinary concentrates from fourteen patients with hyperthyroidism due to Graves' disease, in three subjects with primary hypothyroidism, and in six normal subjects. Immunoreactive thyrotrophin was detectable in eleven subjects with Graves' disease, in one subject with primary hypothyroidism, and in four normal subjects. The mean urinary thyrotrophin concentration was significantly higher in Graves' disease (492+-99.9μU/24h(SEM)(n=11)) than in normal subjects (177+-26.4μU/24h(SEM)(n=4)(P [de

  15. Persistent hyperthyroidism and de novo Graves' ophthalmopathy after total thyroidectomy.

    Science.gov (United States)

    Tay, Wei Lin; Loh, Wann Jia; Lee, Lianne Ai Ling; Chng, Chiaw Ling

    2017-01-01

    We report a patient with Graves' disease who remained persistently hyperthyroid after a total thyroidectomy and also developed de novo Graves' ophthalmopathy 5 months after surgery. She was subsequently found to have a mature cystic teratoma containing struma ovarii after undergoing a total hysterectomy and salpingo-oophorectomy for an incidental ovarian lesion. It is important to investigate for other causes of primary hyperthyroidism when thyrotoxicosis persists after total thyroidectomy.TSH receptor antibody may persist after total thyroidectomy and may potentially contribute to the development of de novo Graves' ophthalmopathy.

  16. Grave's disease associated with immunoglobulin A nephropathy: A rare association.

    Science.gov (United States)

    Khan, I; Bhat, R A; Khan, I; Hameed, I

    2015-01-01

    Immunoglobulin A (Ig A) nephropathy is the most common form of primary glomerulonephritis. The association of Ig A nephropathy with Grave's disease has not been reported so far. We report a case of 20-year-old female with Grave's disease who presented with edema, facial puffiness, and decreased urine output. She was found to be hypertensive with renal failure and nephrotic range proteinuria. Renal biopsy revealed features of Ig A nephropathy. The patient was treated with oral corticosteroids (1 mg/kg/day). To our knowledge, this is the first case showing association of Grave's disease with Ig A nephropathy.

  17. Cheating in the first, second, and third degree: Educators' responses to high-stakes testing Haciendo trampa en el primer, segundo y tercer grado: Las respuestas de los docentes a las evaluaciones con consecuencias severas Engano no primeiro, segundo e terceiro grau: as respostas dos professores às avaliações com conseqüências graves

    Directory of Open Access Journals (Sweden)

    Audrey Amrein-Beardsley

    2010-06-01

    Full Text Available

    Educators are under tremendous pressure to ensure that their students perform well on tests.  Unfortunately, this pressure has caused some educators to cheat.  The purpose of this study was to investigate the types of, and degrees to which, a sample of teachers in Arizona were aware of, or had themselves engaged in test-related cheating practices as a function of the high-stakes testing policies of No Child Left Behind. A near census sample of teachers was surveyed, with valid responses obtained from about 5 percent, totaling just over 3,000 teachers. In addition, one small convenience sample of teachers was interviewed, and another participated in a focus group. Data revealed that cheating occurs and that educators can be quite clever when doing so. But how one defines cheating makes it difficult to quantify the frequency with which educators engage in such practices. Our analysis thus required us to think about a taxonomy of cheating based on the definitions of 1st, 2nd, and 3rd degree offenses in the field of law. These categories were analyzed to help educators better define, and be more aware of others' and their own cheating practices, in an attempt to inform local testing policies and procedures.

    Los educadores están siendo fuertemente presionados para asegurar que sus estudiantes  obtengan buenos resultados en las pruebas de rendimiento. Desafortunadamente, esas presiones hacen que algunos  educadores hagan trampas. El objetivo de este estudio fue investigar los tipos y grados de conocimiento que educadores en el estado de Arizona tenían sobre o que habían participado directamente en prácticas fraudulentas en relación a las políticas de evaluación de desempeño relacionadas con la ley No Child Left Behind. Una muestra cuasi-censal de profesores con un total de 5% de respuestas válidas y poco más de 3.000 profesores fue investigada. Además, un grupo pequeño (muestra de conveniencia

  18. Estrategia de desarrollo de capacidades y el empoderamiento de mujeres en riesgo de violencia familiar grave. Distrito de Ambo; Huánuco-2017.

    OpenAIRE

    Fernández Picón, Clara

    2017-01-01

    El objetivo del estudio fue demostrar que la estrategia de desarrollo de capacidades tiene efecto en el empoderamiento de las mujeres con riesgo de violencia familiar grave, del distrito de Ambo; Huánuco, en el 2017. El estudio fue de enfoque cuantitativo, de tipo cuasi experimental, longitudinal (pre y pos-test), analítico, prospectivo y con grupo experimental y control; con 48 mujeres seleccionadas aleatoriamente. Al grupo experimental se le aplicó la estrategia de desarrollo de capacidades...

  19. Lithium as an Alternative Option in Graves Thyrotoxicosis

    Directory of Open Access Journals (Sweden)

    Ishita Prakash

    2015-01-01

    Full Text Available A 67-year-old woman was admitted with signs and symptoms of Graves thyrotoxicosis. Biochemistry results were as follows: TSH was undetectable; FT4 was >6.99 ng/dL (0.7–1.8; FT3 was 18 pg/mL (3–5; TSI was 658% (0–139. Thyroid uptake and scan showed diffusely increased tracer uptake in the thyroid gland. The patient was started on methimazole 40 mg BID, but her LFTs elevated precipitously with features of fulminant hepatitis. Methimazole was determined to be the cause and was stopped. After weighing pros and cons, lithium was initiated to treat her persistent thyrotoxicosis. Lithium 300 mg was given daily with a goal to maintain between 0.4 and 0.6. High dose Hydrocortisone and propranolol were also administered concomitantly. Free thyroid hormone levels decreased and the patient reached a biochemical and clinical euthyroid state in about 8 days. Though definitive RAI was planned, the patient has been maintained on lithium for more than a month to control her hyperthyroidism. Trial removal of lithium results in reemergence of thyrotoxicosis within 24 hours. Patient was maintained on low dose lithium treatment with lithium level just below therapeutic range which was sufficient to maintain euthyroid state for more than a month. There were no signs of lithium toxicity within this time period. Conclusion. Lithium has a unique physiologic profile and can be used to treat thyrotoxicosis when thionamides cannot be used while awaiting elective radioablation. Lithium levels need to be monitored; however, levels even at subtherapeutic range may be sufficient to treat thyrotoxicosis.

  20. Effect of abnormal thyroid function on the severity of Graves' ophthalmopathy

    NARCIS (Netherlands)

    Prummel, M. F.; Wiersinga, W. M.; Mourits, M. P.; Koornneef, L.; Berghout, A.; van der Gaag, R.

    1990-01-01

    Many clinicians have the impression that treatment of thyroid dysfunction ameliorates ophthalmopathy in Graves' disease. The aim of our study was to relate thyroid function to the severity of Graves' ophthalmopathy. We studied 90 patients with Graves' ophthalmopathy and Graves' hyperthyroidism in

  1. Enfermedad cardíaca grave en la esclerosis sistémica Severe cardiac disease in scleroderma

    Directory of Open Access Journals (Sweden)

    Alejandro R. Grinberg

    2004-10-01

    Full Text Available Una mujer de 36 años de edad con diagnóstico de esclerosis sistémica (ES desarrolló un cuadro agudo de miositis esquelética e insuficiencia cardíaca grave. Evolucionó con shock cardiogénico y a pesar del tratamiento con drogas inotrópicas y altas dosis de corticoides falleció a los cinco días de haber ingresado. La autopsia reveló áreas de necrosis coagulativa miocárdicas con miocitolisis y necrosis en banda de contracción. Son muy pocos los casos comunicados de insuficiencia cardíaca grave asociada a la ES.A 36 year-old female with a diagnosis of systemic sclerosis suffered from an acute episode of skeletal myositis and refractory heart failure with cardiogenic shock. Despite immunosuppressive treatment with high doses of corticosteroids and hemodynamic support she died five days after admission. The autopsy showed cardiac myocytolysis, myocyte necrosis and contraction band necrosis. There are very few reported cases of severe heart failure associated to systemic sclerosis.

  2. Comportamiento del asma bronquial en un área de salud del policlínico Cerro Behavior of bronchial asthma in a health area of the "Cerro" polyclinic

    Directory of Open Access Journals (Sweden)

    Marlene Álvarez Carmenate

    2011-03-01

    Full Text Available Introducción: el asma bronquial es la enfermedad crónica más frecuente en pediatría y una de las principales causas de consulta. Objetivo: describir el comportamiento del asma bronquial como problema de salud. Métodos: trabajo descriptivo, prospectivo, de corte longitudinal, en 309 niños con edades comprendidas entre 0 y 19 años con el diagnóstico de asma bronquial, atendidos en los 15 consultorios médicos del grupo básico de trabajo A del policlínico universitario "Cerro", en el período comprendido entre el 1º de enero de 2007 y el 31 de diciembre de 2007. Método empírico para la obtención de los datos clínicos epidemiológicos, y como técnica, la encuesta a través de un cuestionario. Resultados: 148 pacientes (48 % se encontraban entre 10 y 14 años, 175 (56,6 % del sexo masculino, 136 (44 % fueron clasificados como persistentes ligeros, 140 (58 % presentaron rinitis y 57 (24 % dermatitis. Había fumadores en las viviendas de 303 pacientes (98 %, hacinamiento en 290 casos (94 % y el polvo en el hogar 284 (92 %. Conclusiones: predominio en el grupo de edades de 10 a 14 años, sexo masculino. En cuanto a la severidad de la enfermedad predominó la forma persistente ligera, las manifestaciones atópicas más frecuentes fueron la rinitis y la dermatitis, los principales factores de riesgo fueron el humo del tabaco, el polvo en el hogar y el hacinamiento, y el tratamiento de elección fue el de la crisis. Se observó la falta de organización y unidad de criterios para el enfoque integral de la política intercrisis o de sostén en la atención de los pacientes.Introduction: bronchial asthma is the more frequent chronic disease in Pediatrics and one of the major causes of consultation. Objective: to describe the behavior of bronchial asthma as a health problem. Methods: a longitudinal, prospective and descriptive study was conducted in 309 children aged between 0 and 19 diagnosed with bronchial asthmas seen in the 15 medical

  3. Development of Graves' disease following radiation therapy in Hodgkin's disease

    International Nuclear Information System (INIS)

    Loeffler, J.S.; Tarbell, N.J.; Garber, J.R.; Mauch, P.

    1988-01-01

    Radiation-related thyroid dysfunction is a common occurrence in patients with Hodgkin's disease treated with mantle field radiation. Although chemical and clinical hypothyroidism are most commonly seen, Graves' disease has also been described. We have examined the records of 437 surgically staged patients who received mantle field irradiation between April 1969 and December 1980 to ascertain the frequency of manifestations of Graves' disease. Within this group, seven patients developed hyperthyroidism accompanied by ophthalmic findings typical of those seen in Graves' disease. The actuarial risk of developing Graves' disease at 10 years following mantle irradiation for Hodgkin's disease was 3.3% in female patients and 1% in male patients in this study. The observed/expected ratios were 5.9 and 5.1 for female and male patients, respectively. This observed risk significantly exceeded that seen in the general population

  4. Graves disease with ophthalmopathy following radiotherapy for Hodgkin's disease

    International Nuclear Information System (INIS)

    Jacobson, D.R.; Fleming, B.J.

    1984-01-01

    The number of patients achieving long-term survival following neck irradiation for Hodgkin's disease and other malignancies is increasing. Paralleling this increase in survivors is the development of late complications of the therapy itself. Eleven patients have previously been reported who developed Graves ophthalmopathy 18 months to seven years after receiving neck radiotherapy for nonthyroidal malignancies. The seven patients who had HLA typing were all HLA-B8 negative, despite the reported association of the HLA-B8 antigen with Graves disease. A patient who is HLA-B8 positive who developed Graves ophthalmopathy and hyperthyroidism nine years after receiving mantle radiotherapy for Hodgkin's disease is reported. It is recommended that Graves disease be included among the thyroid diseases that receive consideration during follow-up of patients who have received mantle radiotherapy

  5. Graves' Disease Associated with Cerebrovascular Disease and Antiphospholipid Antibody Syndrome

    Directory of Open Access Journals (Sweden)

    Ines Khochtali

    2010-01-01

    have increased risk for developing thromboembolic accidents, which are favoured by a simultaneous presence of antiphospholipid antibodies syndrome. in this paper, we describe the case of a patient with Graves' disease, who developed strokes with antiphospholipid antibodies syndrome.

  6. Thyroid Function after Subtotal Thyroidectomy in Patients with Graves' Hyperthyroidism

    NARCIS (Netherlands)

    Limonard, E. J.; Bisschop, P. H.; Fliers, E.; Nieveen van Dijkum, E. J.

    2012-01-01

    Background. Subtotal thyroidectomy is a surgical procedure, in which the surgeon leaves a small thyroid remnant in situ to preserve thyroid function, thereby preventing lifelong thyroid hormone supplementation therapy. Aim. To evaluate thyroid function after subtotal thyroidectomy for Graves'

  7. An assessment of psychiatric disturbances in graves disease in a ...

    African Journals Online (AJOL)

    An assessment of psychiatric disturbances in graves disease in a medical college in eastern India. ... standard error of difference, the chi-square test, and paired Student's T-test. ... The common symptoms were insomnia, irritability, and anxiety.

  8. CASE REPORT : GRAVE'S DISEASE PRESENTING AS PARANOID SCHIZOPHRENIA

    OpenAIRE

    Singh, S.K.; Hatwal, A.; Agarwal, J.K.; Bajpai, H.S.; Sharma, I.

    1989-01-01

    SUMMARY The case of a 37 year old male is described who initially presented as paranoid schizophrenia unresponsive to anti-psychotic drug treatment and subsequently developed features of Grave's disease. Treatment with carbimazole alone improved his psychiatric symptoms.

  9. Uso do sulfato de magnésio por via venosa e nebulização para o tratamento da asma aguda na emergência Use of the intravenous and nebulized magnesium sulfate for the treatment of the acute asthma in the emergence

    Directory of Open Access Journals (Sweden)

    Fabiano Timbó Barbosa

    2007-09-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Tem sido mostrado que o sulfato de magnésio apresenta benefícios em adultos e crianças asmáticos, com fraca resposta aos agentes beta-agonistas e corticóides sistêmicos no departamento de emergência. O objetivo deste estudo foi realizar uma revisão não sistemática acerca do tratamento da asma aguda com sulfato de magnésio por via venosa e nebulização na emergência. CONTEÚDO: As primeiras investigações que demonstraram benefício no uso do sulfato de magnésio na asma são de 1938. Os efeitos do sulfato de magnésio podem ser mediados através da ação antagonista do cálcio ou através da função de co-fator em sistemas enzimáticos envolvendo o fluxo iônico através da membrana celular. Foi realizada uma revisão de literatura através da base de dados MedLine nos últimos seis anos (2000 a 2006 e incluídos os artigos publicados na língua inglesa, através do cruzamento dos unitermos asma e sulfato de magnésio. CONCLUSÕES: A administração de rotina do sulfato de magnésio por via venosa e nebulização em pacientes com asma aguda grave que se apresentam no serviço de emergência não é recomendado; entretanto, como um tratamento adjuvante obtém-se algum benefício.BACKGROUND AND OBJECTIVES: Magnesium sulfate has been shown to benefit asthmatic children and adults with poor responses to initial beta-agonist therapy and systemic corticoids in the emergency department. The aim of this study was to realize a no systematic review about the treatment of the acute asthma with intravenous and nebulized magnesium sulfate in the emergence. CONTENTS: The first investigations that demonstrate the benefit in the use of the magnesium sulfate in asthma date to 1938. The effects of magnesium sulfate may be mediated through its action as a calcium antagonist or through its function as a cofactor in enzyme systems involving ion flux across cell membranes. We realized a literature review using Med

  10. Refluxo gastroesofágico e asma na infância: um estudo de sua relação através de monitoramento do pH esofágico Gastroesophageal reflux and asthma in childhood: a study on their relationship using esophageal PH monitoring

    Directory of Open Access Journals (Sweden)

    Beatriz C. Teixeira

    2007-12-01

    Full Text Available OBJETIVOS: Este trabalho tem como objetivo verificar a prevalência do refluxo gastroesofágico em crianças com asma e avaliar se o índice de refluxo tem uma boa sensibilidade e especificidade para o diagnóstico de refluxo gastroesofágico. MÉTODOS: Foram estudadas 69 crianças de 1 a 5 anos, com asma, através do exame de pHmetria de 24 horas. RESULTADOS: A idade das crianças variou de 12,4 a 63,1 meses, com uma média de 30,79, sendo que 62,3% eram do sexo masculino. O refluxo gastroesofágico foi observado em 68,1% das crianças. Quando separados os pacientes em duas categorias (asma moderada e grave, a associação foi de 58,5 e 82,1%, respectivamente. O refluxo gastroesofágico oculto ocorreu em 31,8% dos casos. O índice de refluxo mostrou uma sensibilidade de 89,4%, especificidade de 95,5%, valor preditivo positivo de 97,7% e valor preditivo negativo de 80,8%. CONCLUSÕES: Os resultados obtidos neste estudo indicam uma elevada associação entre o refluxo gastroesofágico e a asma e sugerem que o índice de refluxo, como parâmetro único, tem uma boa sensibilidade e especificidade para o diagnóstico da doença do refluxo gastroesofágico.OBJECTIVES: This study aims at verifying the prevalence of gastroesophageal reflux in asthmatic children, and at determining the sensitivity and specificity of the reflux index for the diagnosis of gastroesophageal reflux disease. METHODS: Sixty-nine children, aged 1-5 years, with asthma, were studied by 24-hour pH monitoring. The patients were randomly selected. RESULTS: Ages varied from 12.4 to 63.1 months, mean age = 30.79 months, and 62.3% were males. Gastroesophageal reflux was observed in 68.1% of the children. The patients were divided into two groups, moderate and severe asthma, and gastroesophageal reflux was diagnosed in 58.5 and 82.1% of the cases, respectively. Occult gastroesophageal reflux occurred in 31.8% of the cases. The reflux index showed an sensitivity of 89.4%, specificity of

  11. Childhood asthma along the United States/ Mexico border: hospitalizations and air quality in two California counties El asma infantil en la frontera mexicana-estadounidense: hospitalizaciones y calidad del aire ambiental en dos condados de California

    Directory of Open Access Journals (Sweden)

    Paul B English

    1998-06-01

    Full Text Available Since the passage of the North American Free Trade Agreement in 1993, there has been an increasing need to monitor environmental health trends that may be related to the rapid industrialization of the United States/Mexico border. We studied two counties on the California/Baja California border to obtain baseline data on trends in childhood asthma hospitalizations and two pollutants that aggravate asthma, ozone and particulate matter (less than 10 microns in diameter, from 1983 to 1994. Hospital discharge records of children 14 years and younger were analyzed, and rates by county, race, and sex were age-adjusted to the 1990 California population. Data on five ozone and particulate matter indices obtained from the California Environmental Protection Agency were used. Imperial County had the highest childhood asthma hospitalization rates in California for non-Hispanic whites and African-Americans, and the second highest for Hispanics. San Diego County had rates below the state average. Over the time period examined, rates in Imperial County increased 59%, while those in San Diego County decreased 9%. Maximum ozone levels increased 64% in Imperial County but decreased 46% in San Diego County. Particulate matter levels were four times higher in Imperial than in San Diego County. High rates of childhood asthma hospitalizations in Imperial County may be partially related to high levels of poverty and worsening air quality conditions produced by increased burdens on the local airshed. Asthma prevalence surveys and binational time-series analyses examining asthma-pollutant relationships are needed.Desde que se firmó el Tratado de Libre Comercio en 1993, ha aumentado la necesidad de monitorear problemas de salud que podrían relacionarse con la rápida industrialización de la frontera mexicana-estadounidense. Estudiamos dos condados de la fontera entre California y Baja California con objeto de obtener datos de base sobre las tendencias observadas de

  12. Epithelial Markers aSMA, Krt14, and Krt19 Unveil Elements of Murine Lacrimal Gland Morphogenesis and Maturation.

    Science.gov (United States)

    Kuony, Alison; Michon, Frederic

    2017-01-01

    As an element of the lacrimal apparatus, the lacrimal gland (LG) produces the aqueous part of the tear film, which protects the eye surface. Therefore, a defective LG can lead to serious eyesight impairment. Up to now, little is known about LG morphogenesis and subsequent maturation. In this study, we delineated elements of the cellular and molecular events involved in LG formation by using three epithelial markers, namely aSMA, Krt14, and Krt19. While aSMA marked a restricted epithelial population of the terminal end buds (TEBs) in the forming LG, Krt14 was found in the whole embryonic LG epithelial basal cell layer. Interestingly, Krt19 specifically labeled the presumptive ductal domain and subsequently, the luminal cell layer. By combining these markers, the Fucci reporter mouse strain and genetic fate mapping of the Krt14 + population, we demonstrated that LG epithelium expansion is fuelled by a patterned cell proliferation, and to a lesser extent by epithelial reorganization and possible mesenchymal-to-epithelial transition. We pointed out that this epithelial reorganization, which is associated with apoptosis, regulated the lumen formation. Finally, we showed that the inhibition of Notch signaling prevented the ductal identity from setting, and led to a LG covered by ectopic TEBs. Taken together our results bring a deeper understanding on LG morphogenesis, epithelial domain identity, and organ expansion.

  13. Prevalência da asma e da rinite em adolescentes de 13 anos do Porto, Portugal

    Directory of Open Access Journals (Sweden)

    Helena Falcão

    2008-11-01

    Full Text Available Resumo: Introdução: As prevalências da asma e rinite têm aumentado nas últimas décadas, mas nos últimos anos tem sido referida a sua estabilização ou mesmo diminuição.Objectivo: O objectivo foi o de descrever a prevalência de rinite, asma ou sintomas do tipo da asma em adolescentes urbanos de 13 anos.Métodos: Os participantes elegíveis foram todos os alunos das escolas públicas e privadas do Porto, nascidos em 1990; 2161 (77,5% concordaram em participar. Através de questionários autoaplicados, a informação recolhida contemplou aspectos sociais, demográficos, comportamentais, história clínica de asma e doenças alérgicas do adolescente e família. Foi usada a versão portuguesa do International Study of Asthma and Allergies in Childhood’s (ISAAC e foram efectuadas espirometrias.Resultados: Nesta amostra de adolescentes urbanos de 13 anos, a prevalência da asma durante a vida foi de 12,9%, 84,4% com diagnóstico médico. A pieira durante a vida foi 18,3% e no último ano de 9,3%. A rinite foi relatada por 10,1%, mas a prevalência durante a vida de adolescentes com espirros, rinorreia serosa ou obstrução nasal, foi de 32,0%, e no último ano de 27,4%.Conclusão: Verificou-se uma estabilização ou mesmo diminuição da prevalência dos sintomas e diagnóstico de asma e rinite nos adolescentes do Porto, quando comparada com os resultados do ISAAC em 2002, tal como noutras investigações na Europa. A asma e a rinite estão frequentemente presentes no mesmo doente e a tosse nocturna é um importante sintoma que surge associado aos sintomas nasais. A função pulmonar permitiu discriminar os adolescentes com queixas respiratórias.Rev Port Pneumol 2008; XIV (6: 747-768 Abstract: Background: The prevalence of asthma and rhinitis has been increasing over the past few decades, but the last few years have seen these rates

  14. Risk factors for asthma and cough among Hispanic children in the southwestern United States of America, 2003-2004 Factores de riesgo de asma y tos en niños hispanos en el suroeste de los Estados Unidos de América, 2003-2004

    Directory of Open Access Journals (Sweden)

    Melissa Gonzales

    2007-05-01

    de la madre (México frente a los Estados Unidos de América en la prevalencia de asma y tos seca nocturna en niños de 2-12 años de edad que viven en el suroeste de los Estados Unidos de América. MÉTODOS: Los datos se colectaron de noviembre de 2003 a marzo de 2004 como parte de una encuesta de salud de madres hispanas con hijos pequeños, que solicitaron servicios de emergencia, nutrición o clínicos. Se obtuvo la información sobre el estado de salud respiratoria de un hijo seleccionado aleatoriamente por cada madre nacida en los Estados Unidos de América (n = 144 o en México (n = 125. Se colectó información sobre las variables sociodemográficas de la madre y del hogar, el hábito de fumar, los antecedentes de asma de los padres y la exposición del niño al HAT en habitaciones o automóviles en los siete días previos. Las razones de prevalencia ajustadas se estimaron mediante modelos de regresión de Poisson modificados. RESULTADOS: La mayoría de las variables sociodemográficas y de exposición al HAT presentaron diferencias significativas según el país de nacimiento de la madre. La prevalencia de asma según el modelo fue de 1,95 (intervalo de confianza de 95% [IC95%] = 1,03 a 3,68 veces mayor en niños de madres nacidas en Estados Unidos de América que en los de madres nacidas en México. Esta diferencia se mantuvo después de controlar por los factores de riesgo de asma conocidos, entre ellos los antecedentes de asma de los padres, las variables socioeconómicas y demográficas y la exposición del niño al HAT. La exposición reciente del niño al HAT en automóviles se asoció con la tos seca nocturna (razón de prevalencia ajustada [RP] = 1,94; IC95% = 1,19 a 3,15 y asma (RP = 2,09; IC95% = 0,99 a 4,39. CONCLUSIONES: La exposición al HAT en automóviles es un importante factor de riesgo de asma y de tos seca nocturna en niños hispanos en el suroeste de los Estados Unidos de América, independientemente del país de nacimiento de la madre

  15. Study progress on free radicals and graves disease

    International Nuclear Information System (INIS)

    Zhang Ruiguo; Jin Jianhua

    2009-01-01

    Free radical-mediated oxidative injury has been closely implicated in the occurrence and development of many diseases. Graves disease was also accompanied by changes of the free radicals, especially for reactive oxygen species and reactive nitrogen, et al, and the oxidative stress can cause a certain degree of injury on the thyroid and other human important organs. Antithyroid drug and 131 I treatment of Graves disease, the oxidative and antioxidative parameters can also be changed. (authors)

  16. An evaluation of supervoltage orbital irradiation for Graves' opthalmopathy

    International Nuclear Information System (INIS)

    Teng, C.S.; Crombie, A.L.; Hall, R.; Ross, W.M.

    1980-01-01

    Twenty patients with moderately severe ophthalmopathy due to Graves' disease or ophtalmic Graves' disease were treated by supervoltage orbital radiotherapy generated by a linear accelerator. Seven patients (35%) showed some response within 3 weeks of the treatment, four patients (20%) improved minimally while nine patients (45%) were unchanged. Improvement was noted mainly in soft tissue changes while proptosis decreased in only four patients. With one exception, ophthalmoplegia did not improve after the radiotherapy. The benefit obtained with the treatment was not impressive. (author)

  17. Airway complication occurring during radioiodine treatment for Graves' disease

    International Nuclear Information System (INIS)

    Kinuya, Seigo; Yoneyama, Tatsuya; Michigishi, Takatoshi

    2007-01-01

    Airway complications rarely occur in 131 I radioiodine therapy for Graves' disease. This study presents two cases in which 131 I therapy caused this acute complication. The patients complained of the symptom 6 h and 33 h after administration of 131 I. A histamine H1 receptor antagonist and hydrocortisone rapidly resolved symptoms in both cases. These two cases remind physicians that 131 I therapy for Graves' disease may cause potentially life-threatening complications. (author)

  18. Sindroma de Churg-Strauss: um diagnóstico de asma e eosinofília

    Directory of Open Access Journals (Sweden)

    Tiago Tribolet de Abreu

    2001-11-01

    Full Text Available RESUMO: Introdução: O S. de Churg-Strauss (SCS é uma entidade clínica em que um quadro de asma e eosinofilia coexiste com um atingimento multissistémico.Caso-clínico: Um homem de 63 anos, com diagnóstico de asma e rinite alérgica desde os 55 anos, inicia um quadro de febre, artrite, polineuropatia e hematúria. Verificou-se a existência de eosinofilia marcada e sinusopatia maxilar e etmoidal bilateral. Iniciou corticoterapia, com regressão completa do quadro clínico e laboratorial. Está actualmente assintomático, com Prednisolona 5 mg/dia.Discussão: Revendo os diagnósticos diferenciais de doença pulmonar com eosinofilia,verificámos que a presença de atingimento extrapulmonar permite considerarmos o SCS e o S. hipereosinofílico idiopático como únicas hipóteses. A existência de asma selecciona o SCS como o diagnóstico correcto.Conclusões: a perante um doente com asma e eosinofilia (superior a 10%, o S. de Churg-Strauss é um diagnóstico a ter sempre presente; b o diagnóstico é principalmente clínico, de acordo com os critérios de classificação; c a corticoterapia é muito eficaz e o seu desmame lento permite doses de manutenção baixas.REV PORT PNEUMOL 2001; VII (6: ABSTRACT: Background: The Churg-Strauss syndrome (CSS is a disease in which asthma and eosinophilia occur with multisystemic manifestations.Case-report: A 63 year old male, with a diagnosis of asthma and allergic rhinitis for 8 years, has fever, arthritis, peripheral neuropathy and hematuria. Marked eosinophilia and sinusitis were found. Corticosteroids were given, with complete clinical and laboratorial remission. The patient is asymptomatic with a daily dose of 5 mg of Prednisolone.Discussion: Reviewing the differential diagnosis of pulmonary disease and eosinophilia, the extrapulmonary involvement only exists in the CSS and the hypereosinophilic syndrome. Asthma is present only in the former, and so the Churg-Strauss syndrome was the correct

  19. Controle ambiental e crises de asma em domicílios- estudo descritivo em residências de 5 unidades do Programa de Saúde da Família no Território 1 - Camaragibe PE

    OpenAIRE

    Maria Ribeiro Costa, Roseane

    2012-01-01

    Realizou-se um estudo transversal, descritivo, exploratório, para avaliar o grau de controle ambiental e crises de asma encontrados em domicílios de crianças e adolescentes, assim como, o conhecimento de mães e agentes comunitários de saúde sobre asma, no município de Camaragibe, localizado na região metropolitana do Recife. Objetivos específicos: 1) Identificar os acessórios presentes no quarto/sala do domicílio que pode3m desencadear crises de asma. 2) Verificar a freqüênc...

  20. Hyperparathyroidism after radioactive iodine therapy for Graves disease

    International Nuclear Information System (INIS)

    Esselstyn, C.B. Jr.; Schumacher, O.P.; Eversman, J.; Sheeler, L.; Levy, W.J.

    1982-01-01

    The association of external ionizing radiation to the head and neck and the subsequent development of hyperfunctioning parathyroid glands has been documented in recent years. This also has been demonstrated experimentally in animals. Despite the numbers of patients with Graves disease who have been treated with radioactive iodine, there are no reports in the literature of parathyroid surgery for hyperparathyroidism secondary to earlier treatment with radioactive iodine for Graves disease. This report describes the operative and pathologic findings in four patients with hyperparathyroidism. These patients had previously been treated with radioactive iodine for Graves disease. The pathologic findings at surgery included in three cases a single enlarged hyperplastic gland consistent with a parathyroid adenoma. One patient had hyperplasia of all four glands. The two largest glands and halves of the two remaining glands were removed. In a long-term follow-up of children and adolescents treated with radioactive iodine for Graves disease, Levy and Schumacher found calcium elevations in 10 of 159 patients. The increased incidence of hyperparathyroidism following radioactive iodine treatment for Graves disease in children and adolescents would seem several times higher than normal. Whether adults who have radioactive iodine treatment for Graves disease have a similar increase incidence is not known. Meanwhile it would seem reasonable to suggest that patients whose hyperthyroidism is treated with radioactive iodine should have their serum calcium levels determined at 5-year intervals

  1. Delineation of graves using electrical resistivity tomography

    Science.gov (United States)

    Nero, Callistus; Aning, Akwasi Acheampong; Danuor, Sylvester K.; Noye, Reginald M.

    2016-03-01

    A suspected old royal cemetery has been surveyed at the Kwame Nkrumah University of Science and Technology (KNUST) campus, Kumasi, Ghana using Electrical Resistivity Tomography (ERT) with the objective of detecting graves in order to make informed decisions with regard to the future use of the area. The survey was conducted on a 10,000 m2 area. Continuous Vertical Electrical Sounding (CVES) was combined with the roll along technique for 51 profiles with 1 m probe separation separated by 2 m. Inverted data results indicated wide resistivity variations ranging between 9.34 Ωm and 600 Ωm in the near surface. Such heterogeneity suggests a disturbance of the soil at this level. Both high (≥ 600 Ωm) and low resistivity (≤ 74.7 Ωm) anomalies, relative to background levels, were identified within the first 4 m of the subsurface. These were suspected to be burial tombs because of their rectangular geometries and resistivity contrasts. The results were validated with forward numerical modeling results. The study area is therefore an old cemetery and should be preserved as a cultural heritage site.

  2. Lymphocyte-platelet crosstalk in Graves' disease.

    Science.gov (United States)

    Kuznik, Boris I; Vitkovsky, Yuri A; Gvozdeva, Olga V; Solpov, Alexey V; Magen, Eli

    2014-03-01

    Platelets can modulate lymphocytes' role in the pathophysiology of thyroid autoimmune diseases. The present study was performed to clarify the status of platelet-lymphocyte subpopulations aggregation in circulating blood in patients with Graves' disease (GD). One hundred and fifty patients with GD (GD group) and 45 hyperthyroid patients with toxic multinodular goiter (TMG group) were recruited in the study. Control group consisted 150 healthy subjects. Immunophenotyping of lymphocytes was performed by flow cytometry. Detection of lymphocyte-platelet aggregates (LPAs) was done using light microscope after Ficoll-gradient centrifugation. The group of GD patients exhibited reduced CD8 lymphocyte and higher CD19 cell counts compared with TMG group and healthy controls. A greater number of activated CD3, HLA-DR+ lymphocytes were observed in GD than in TMG group and control group. GD group was characterized by lower blood platelet count (232 ± 89 × 10 cells/µL) than TMG group (251 ± 97 × 10 cells/µL; P TMG group (116 ± 67/µL, P < 0.005) and control group (104 ± 58 /µL; P < 0.001). GD is associated with higher levels of activated lymphocytes and lymphocyte-platelet aggregates.

  3. Radioiodine treatment for pediatric hyperthyroid Grave's disease.

    Science.gov (United States)

    Chao, Ma; Jiawei, Xie; Guoming, Wang; Jianbin, Liu; Wanxia, Liu; Driedger, Al; Shuyao, Zuo; Qin, Zhang

    2009-10-01

    Grave's disease (GD) is an autoimmune disease in which excessive amounts of thyroid hormones circulate in the blood. Treatment for pediatric GD includes (1) antithyroid drugs (ATD), (2) radioiodine, and (3) thyroidectomy. Yet, the optimal therapy remains controversial. We collected studies from all electronically available sources as well as from conferences held in China. All studies using radioiodine and/or ATD and/or thyroidectomy were included. Information was found on 1,874 pediatric GD patients treated with radioiodine, 1,279 patients treated with ATD and 1,362 patients treated surgically. The cure rate for radioiodine was 49.8%; the incidence of hypothyroidism, 37.8%; of relapse, 6.3%; of adverse effects, 1.55%; and of drop outs, 0.6%. These data show that radioiodine treatment is safe and effective in pediatric GD with significant lower incidence of relapse and adverse effects but significantly higher incidence of hypothyroidism as compared with both ATD and thyroidectomy. For the time being, radioiodine treatment for pediatric GD remains an excellent first-line therapy and a good second-line therapy for patients with ATD failure, severe complications, or poor compliance.

  4. Concurrence of Grave's disease and Hashimoto's thyroiditis.

    Science.gov (United States)

    Sato, T; Takata, I; Taketani, T; Saida, K; Nakajima, H

    1977-01-01

    Early histological changes in the thyroid gland were examined in 30 patients with juvenile thyrotoxicosis, by means of needle biopsy. Based on the degree of lymphocytic infiltration and degenerative changes in follicular epithelium, results were classified into four groups. A: hyperplastic changes without cellular infiltration (6 patients, 20%); B: hyperplastic changes with areas of focal thyroiditis less than 30% of specimen (10 patients, 33%); C: those with 30 to 60% areas ot thyroiditis (10 patients, 33%); D: almost diffuse thyroiditis (4 patients, 13%). Moderate to severe lymphocytic thyroiditis was frequently present in the early stage of hyperplastic thyroid glands. The clinical significance of the 4 histological groups was evaluated. Neither clinical signs nor routine laboratory tests could differentiate these groups except group D, in which thyrotoxic signs were mild and transient. However, serum antithyroid antibodies tended to increase in accordance with severity of thyroiditis. The rate of remission was high in groups C and D, whereas relapse was frequent in group A. These results suggest that Grave's disease and chronic lymphocytic thyroiditis are closely related in the early stage of thyrotoxicosis in children, and that the clinical course may be considerably altered by the degree of associated thyroiditis. Images Fig. 1 Fig. 2 Fig. 3 Fig. 3 PMID:580172

  5. Riesgo de Violencia Grave contra la Pareja.

    Directory of Open Access Journals (Sweden)

    Holguer Romero

    2015-10-01

    Se analiza todos los factores que alteran los resultados de la evaluación pericial. En los resultados se explica porque se debe modificar ciertos ítems. Terminado este proceso, se trabajara con el reactivo modificado a fin de establecer un análisis comparativo, terminado el estudio se pondrá a consideración del Consejo de la Judicatura del Ecuador, para la investigación se contara con el respaldo técnico científico de la Universidad Nacional Mayor San Marcos.

  6. Respuesta al tratamiento de la Enfermedad de Graves-Basedow en pacientes pediátricos

    Directory of Open Access Journals (Sweden)

    Martha Calagua Quispe

    2014-04-01

    Full Text Available Objetivos: Describir la respuesta clínica y bioquímica al tratamiento del hipertiroidismo por enfermedad de Graves en pacientes pediátricos. Diseño: Estudio retrospectivo. Institución: Instituto Nacional de Salud del Niño, Lima, Perú. Participantes: Niños con enfermedad de Graves. Métodos: Se incluyó 32 pacientes con diagnóstico de hipertiroidismo por Enfermedad de Graves, entre 1996 a 2007. Se consideró remisión, cuando se encontraban asintomáticos y bioquímicamente eutiroideos, luego de 6 meses de suspendido el tratamiento; y recaída, si luego de este periodo de tiempo, se encontró valores hormonales alterados. Principales medidas de resultados: Remisión o recaída luego del tratamiento. Resultados: Al diagnóstico, la edad promedio fue 10,5 años (3,2 a 17,9 años; 26 pacientes (81,2% fueron de sexo femenino, 13 (40,6% púberes y 19 (59,3% pre-púberes. Los síntomas y signos más frecuentes fueron bocio, sudoración, nerviosismo, pérdida de peso, taquicardia y exoftalmos. Se usó metimazol como primera opción terapéutica a una dosis inicial promedio de 0,78 mg/kg/ día (0,4 a 2 mg/kg/día. La TSH (57,1% y el T4L (50% alcanzaron valores normales entre los 6 y 8 meses. Se observó remisión en 11 pacientes (34,3%, 3 (9,3% sufrieron recaída, 12 (37,5% pasaron a tratamiento con radioyodo (I131 y 6 (18,7% continuaron recibiendo metimazol. La remisión de la enfermedad se alcanzó a los 2,81± 0,91 años de tratamiento (rango de 1.5 a 4,8; 4,1% remitió luego del primer año, y 35,3%, 37,5% y 25% luego del segundo, tercer y cuarto año de tratamiento, respectivamente. La edad promedio de los que recibieron I131 fue 14,6 años (7,1 a 19,6 años, a una dosis alrededor de 7mCi. El 75% de ellos remitió a los 0,64± 0,60 años (rango de 0,16 a 1,5 años. Conclusiones: El hipertiroidismo por enfermedad de Graves es de relativa frecuencia en pediatría. Se obtuvo remisión en 34,3% de pacientes tratados con metimazol en un tiempo

  7. Interface entre a natação e o tratamento da asma sob a perspectiva do paciente asmático

    Directory of Open Access Journals (Sweden)

    João Lucas Pinto Matias

    2017-10-01

    Full Text Available Objetivo: analisar a interface entre a natação e o tratamento da asma sob a perspectiva do praticante asmático. Método: trata-se de pesquisa qualitativa, realizada com cinco crianças e adolescentes, praticantes de natação. Foi utilizada como técnica de construção das informações empíricas a entrevista semiestruturada e, para análise das informações, a análise de conteúdo do tipo análise temática, em que emergiram dois núcleos de sentido: descoberta e percepção da doença e relação entre o tratamento da asma e a natação. Resultados: o reconhecimento do exercício físico como possível agravo da asma existe há décadas, todavia, há igual período de tempo se reconhece que o exercício físico regular e planejado torna-se um fator redutivo da frequência das crises asmáticas. O tratamento da asma para os sujeitos vem como algo substancial e, quando atrelado à prática esportiva, mais especificamente a natação, torna-se um eficiente manejo na trajetória fisiopatológica. Considerações finais: a asma tem sido um fator importante para adesão e manutenção na natação e que, de acordo com os participantes, a sua prática tem melhorado em diversos aspectos os sintomas da doença.

  8. Relationship between the management of Graves' disease and the course of Graves' ophthalmopathy: a systematic review

    International Nuclear Information System (INIS)

    Li Suping; Kuang Anren

    2008-01-01

    Objective: To perform literature search and review on the controversial relationship between therapies of hyperthyroidism due to Graves' disease (GD) and the course of Graves' ophthalmopathy (GO). Methods: We searched the database of MEDLINE (1966-2006.3), EMBASE (1984-2005), Cochrane Library(2006 No. 1), CBMdisc (1978.1-2006.4) and CNKI (1994-2006). The methodological quality of the studies selected for review was assessed according to the quality assessment criteria suggested by the Cochrane systematic review guideline. Meta-analysis was performed by RevMan 4.2 software. Results: Eight studies were included in the systematic review. Meta-analysis showed that there was statistically significant difference between mi and other forms of therapy [surgery or antithyroid drugs (ATD)] (test value: 2.31, 5.97, 3.70, 5.55; all P 0.05). There were not yet any studies on the impact between early prevention of hypothyroidism after mi therapy and GO. Conclusions: Based on meta-analysis on literature data, if early measures are not performed to prevent hypothyroidism after mi therapy, it may induce or aggravate GO more frequently than ATD or surgical treatment. Symptomatic relief of GO after 131 I therapy is also less effective than the other 2 forms of therapy. Therefore, 131 I therapy should be delivered carefully in those patients with GO. (authors)

  9. Pretibial myxedema without ophthalmopathy: an initial presentation of Graves' disease.

    Science.gov (United States)

    Lohiya, Sheela; Lohiya, Vipin; Stahl, Elizabeth J

    2013-07-01

    To report a rare case of Graves' disease without ophthalmopathy presenting with pretibial myxedema (PM) as an initial presentation. We present the clinical history, physical findings, laboratory studies and biopsy data of a 62-year-old man with a history of uncontrolled type 2 diabetes (DM2) presenting with arm and leg skin lesions in the absence of other physical findings. Histopathology confirmed PM. Graves' disease and its association with PM without Graves' ophthalmopathy and the pertinent literature are reviewed. A 60-year-old man with a history of uncontrolled DM2 presented for glycemic management. He described symptoms of anxiety, insomnia and fatigue for the last 5 to 6 months. He described diffuse chest pain, occasionally associated with palpitations, and a 50-pound weight loss. He also complained of severe itching and burning of his arms and legs for the past several months. Subsequent thyroid studies revealed hyperthyroidism suggestive of Graves' disease. In the interim, he was hospitalized for atrial flutter and was cardioverted. After being started on methimazole, his symptoms abated. His skin lesions were biopsied, and the leg biopsy was consistent with PM. He however had no lid lag or proptosis characteristic of Graves' disease. He subsequently underwent radioiodine ablation. His hyperglycemia was better control led after treatment of his hyperthyroidism. PM is an autoimmune manifestation of Graves' disease. Almost all cases of thyroid dermopathy are associated with relatively severe ophthalmopathy. Usually ophthalmopathy appears first and dermopathy much later. However, this case represents a rare initial presentation of Graves' disease with PM without ophthalmologic symptoms or findings. Hyperthyroidism is typically associated with worsening glycemic control and increased insulin requirements. In patients with diabetes having hyperthyroidism, deterioration in glycemic control should be anticipated and treatment should be adjusted accordingly

  10. Graves' disease: diagnostic and therapeutic challenges (multimedia activity).

    Science.gov (United States)

    Kahaly, George J; Grebe, Stefan K G; Lupo, Mark A; McDonald, Nicole; Sipos, Jennifer A

    2011-06-01

    Graves' disease is the most common cause of hyperthyroidism in the United States. Graves' disease occurs more often in women with a female:male ratio of 5:1 and a population prevalence of 1% to 2%. A genetic determinant to the susceptibility to Graves' disease is suspected because of familial clustering of the disease, a high sibling recurrence risk, the familial occurrence of thyroid autoantibodies, and the 30% concordance in disease status between identical twins. Graves' disease is an autoimmune thyroid disorder characterized by the infiltration of immune effector cells and thyroid antigen-specific T cells into the thyroid and thyroid-stimulating hormone receptor expressing tissues, with the production of autoantibodies to well-defined thyroidal antigens, such as thyroid peroxidase, thyroglobulin, and the thyroid-stimulating hormone receptor. The thyroid-stimulating hormone receptor is central to the regulation of thyroid growth and function. Stimulatory autoantibodies in Graves' disease activate the thyroid-stimulating hormone receptor leading to thyroid hyperplasia and unregulated thyroid hormone production and secretion. Below-normal levels of baseline serum thyroid-stimulating hormone receptor, normal to elevated serum levels of T4, elevated serum levels of T3 and thyroid-stimulating hormone receptor autoantibodies, and a diffusely enlarged, heterogeneous, hypervascular (increased Doppler flow) thyroid gland confirm diagnosis of Graves' disease (available at: http://supplements.amjmed.com/2010/hyperthyroid/faculty.php). This Resource Center is also available through the website of The American Journal of Medicine (www.amjmed.com). Click on the “Thyroid/Graves' Disease” link in the “Resource Centers” section, found on the right side of the Journal homepage. Copyright © 2011 Elsevier Inc. All rights reserved.

  11. Introducción a las complicaciones graves de la quimioterapia que debe enfrentar un cardiólogo

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    Patricia Avellana

    2007-01-01

    Full Text Available La aplicación de diferentes esquemas farmacológicos para el tratamiento oncológico ha tenido en los últimos años un gran crecimiento, en muchos casos con efectos curativos o claramejoría de la sobrevida y la calidad de vida. Algunos esquemas incluyen drogas que pueden provocar efectos cardiotóxicos graves, lo que motiva la consulta a los cardiólogos que en la mayor parte de los casos no hemos tenido entrenamiento en esta complicación. En estarevisión se resumen mecanismos de acción y efectos adversos de diferentes drogas de uso frecuente en patología oncológica y se exponen casos clínicos con reacciones adversas graves, con dificultades en la toma de decisiones. Finalmente, se discuten los aspectos para tener en cuenta para la prevención, el control y el tratamiento de la cardiotoxicidad por agentes quimioterapéuticos.

  12. Glucocorticoids in the treatment of asthma in children Los glucocorticoides en el tratamiento del asma en pediatría

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    Olga Francisca Salazar Blanco

    1998-04-01

    Full Text Available Today, asthma is considered an inflammatory disease; steroids could be the drugs of choice for its treatment since they work at different points of the asthmatic reaction, decreasing the infiltration of inflammatory cells, and inhibiting the production of some of them and the release of citokines and other proinflammatory agents; they also diminish mucus secretion in the submucosal glands, improve the response of B2 receptors to bronchodilators and reduce vascular permeability. These and other actions manifest themselves in clinical improvement, less frequent acute crises, hospitalizations and consultations, and lesser deterioration of pulmonary function. Though inhaled corticosteroids are safe and effective drugs in children, they must be used at minimal doses and during the shortest time required by patients. Inadequate use of systemic corticosteroids, either oral or parenteral, can have undesirable effects, some of them irreversible. Corticosteroids neither cure asthma nor reduce its mortality; that is the reason for the active search of other substances or strategies to reduce or block the inflammatory process or the disease itself. El asma se considera hoy una enfermedad inflamatoria para la cual los esteroides podrían ser fármacos de primera elección. Ellos actúan en diferentes puntos de la reacción asmática, disminuyen el infiltrado de células inflamatorias e inhiben la producción de algunas de ellas, así como la liberación de citoquinas y agentes proinflamatorios; reducen la secreción de moco en las glándulas submucosas, mejoran la respuesta de los receptores 82 a los broncodilatadores y controlan la permeabilidad vascular; éstas y otras acciones se traducen en una mejoría clínica de los pacientes que sufren crisis agudas, en disminución del número de hospitalizaciones y consultas y, a largo plazo, en un menor deterioro de la función pulmonar. Los esteroides por vía inhalatoria para el tratamiento del asma son f

  13. A asma e a DPOC na visão do pneumologista Asthma and COPD according to the pulmonologist

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    Hisbello da Silva Campos

    2009-04-01

    Full Text Available OBJETIVO: Avaliar como o pneumologista vê o impacto da asma e da DPOC na sua clientela, e como ele vem tratando essas doenças. MÉTODOS: Inquérito com 227 pneumologistas participantes do VI Congresso de Asma e II Congressos Brasileiros de DPOC e de Tabagismo, realizados em 2007. RESULTADOS: As respostas dos pneumologistas mostraram que a DPOC é um problema de saúde pública igual ou maior que a asma, e que a DPOC causa inúmeros transtornos para o doente e para seus familiares. Na escolha do dispositivo inalatório, a simplicidade de uso é mais importante que o custo, havendo discreta predileção pelos sistemas Aeroliser® e Diskus®. A associação entre budesonida e formoterol foi a conduta terapêutica mais citada para o tratamento continuado do asmático sintomático, enquanto o brometo de tiotrópio foi o medicamento preferido pela maior parte para o tratamento continuado do portador de DPOC. A escolha do esquema para o tratamento continuado do asmático e do portador de DPOC é especialmente influenciada pela publicação de resultados de ensaios terapêuticos na literatura. CONCLUSÕES: A opinião do pneumologista sobre os temas abordados está de acordo com a literatura especializada.OBJECTIVE: To evaluate how pulmonologists view the impact that asthma and COPD has on their patients, as well as how they treat these diseases. METHODS: Survey including 227 pulmonologists participating in the VI Brazilian Asthma Conference, II Brazilian COPD Conference and II Brazilian Smoking Conference, all of which were held in 2007. RESULTS: According to the answers given by the pulmonologists, COPD is a public health problem of equal or greater importance than asthma, and COPD causes various disruptions in the lives of patients and their family members. When prescribing an inhalation device, pulmonologists feel that simplicity of use is more important than is the cost. There was a slight preference for the Aeroliser® and Diskus® systems. The

  14. Glicanos de la vellosidad trofoblástica en la anemia ferropénica y la preeclampsia grave

    OpenAIRE

    Gómez-Gutiérrez, Alejandra María; Parra-Sosa, Beatriz Elena; Bueno-Sánchez, Julio Cesar

    2015-01-01

    Introducción: Las glicoproteínas de la membrana del sincitiotrofoblasto (STB) se encuentran en contacto con la sangre materna, por lo que pueden participar en la comunicación en la interface materno-fetal. Objetivo: caracterizar patrones de glicanos de la vellosidad trofoblástica de mujeres sanas, anémicas por deficiencia de hierro y preeclámpticas graves de inicio temprano. Materiales y métodos: se obtuvieron extractos proteínicos de vellosidad placentaria de tercer trimestre y se determinó ...

  15. Trastornos de personalidad y psicopatía en hombres condenados por violencia grave contra la pareja

    OpenAIRE

    Fernández-Montalvo, Javier; Echeburúa, Enrique

    2008-01-01

    En este artículo se lleva a cabo un estudio de las alteraciones de personalidad (trastornos de personalidad y psicopatía) asociadas a los maltratadores a la mujer que se encuentran en prisión. Para ello se contó con una muestra de 76 hombres condenados por un delito de violencia grave contra la pareja, que cumplimentaron el MCMI-II antes de comenzar dentro de la prisión un programa de tratamiento para la violencia. Asimismo todos los participantes fueron evaluados de forma heteroaplicada medi...

  16. Preclinical evaluation of 99mTc(CO)3-aspartic-N-monoacetic acid, 99mTc(CO)3(ASMA), a new renal radiotracer with pharmacokinetic properties comparable to 131I-OIH

    Science.gov (United States)

    Lipowska, Malgorzata; Klenc, Jeffrey; Marzilli, Luigi G.; Taylor, Andrew T.

    2014-01-01

    In an ongoing effort to develop a renal tracer with pharmacokinetic properties comparable to PAH and superior to those of both 99mTc-MAG3 and 131I-OIH, we evaluated a new renal tricarbonyl radiotracer based on the aspartic-N-monoacetic acid ligand, 99mTc(CO)3(ASMA). The ASMA ligand features two carboxyl groups and an amine function for the coordination of the {99mTc(CO)3}+ core as well as a dangling carboxylate to facilitate rapid renal clearance. Methods rac-ASMA and L-ASMA were labeled with a 99mTc-tricarbonyl precursor and radiochemical purity of the labeled products was determined by HPLC. Using 131I-OIH as an internal control, we evaluated biodistribution in normal rats with 99mTc(CO)3(ASMA) isomers and in rats with renal pedicle ligation with 99mTc(CO)3(rac-ASMA). Clearance studies were conducted in 4 additional rats. In vitro radiotracer stability was determined in PBS buffer pH 7.4 and in challenge studies with cysteine and histidine. 99mTc(CO)3(ASMA) metabolites in urine were analyzed by HPLC. Results Both 99mTc(CO)3(ASMA) preparations had > 99% radiochemical purity and were stable in PBS buffer pH 7.4 for 24 h. Challenge studies on both revealed no significant displacement of the ligand. In normal rats, % injected dose in urine at 10 and 60 min for both preparations averaged 103% and 106% that of 131I-OIH, respectively. The renal clearances of 99mTc(CO)3(rac-ASMA) and 131I-OIH were comparable (P = 0.48). The tracer was excreted unchanged in the urine, proving its in vivo stability. In pedicle-ligated rats, 99mTc(CO)3(rac-ASMA) had less excretion into the bowel (P ASMA) complexes have pharmacokinetic properties in rats comparable to or superior to those of 131I-OIH, and human studies are warranted for their further evaluation. PMID:22717977

  17. Significance of changes of serum TPOAb and TRAb levels in patients with Graves' disease (GD)

    International Nuclear Information System (INIS)

    Zhang Zhongshu Xu Ruiji; Wang Guohong

    2006-01-01

    Objective: To investigate the significance of changes of serum TPOAb and TRAb levels in patients with Graves' dis- ease (GD). Methods: Serum TPOAb (with RIA) and TRAb (with RRA) levels were determined in 27 patients with Graves' disease, before treatment 10 patients with Graves' disease clinically cured and 35 controls. Results: The serum levels and positive rates of TPOAb and TRAb in patients with Graves' disease before treatment were significantly higher than those in the patients with Graves' disease clinically cured and controls (P<0.01). Conclusion: TPOAb and TRAb were involved in the pathogenesis of Graves' dis- ease and could be used as diagnostic and treatment indicators. (authors)

  18. Avaliação da qualidade de vida e mortalidade em pacientes com eventos cardíacos graves no pós-operatório Evaluación de la calidad de vida y de la mortalidad en pacientes con eventos cardíacos mayores en el postoperatorio Quality of life and mortality assessment in patients with major cardiac events in the postoperative period

    Directory of Open Access Journals (Sweden)

    Fernando José Abelha

    2010-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Complicações cardiovasculares no pós-operatório associam-se a elevadas mortalidade e morbidade. Poucos estudos avaliaram o grau de dependência desses doentes e a percepção da sua saúde. O objetivo deste trabalho foi avaliar a mortalidade e a qualidade de vida em doentes que desenvolveram eventos cardíacos graves (EC no pós-operatório. MÉTODO: Estudo retrospectivo numa Unidade de Tratamento Intensivo Cirúrgica (UTI-Cirúrgica, entre março de 2006 e março de 2008. Os doen tes foram avaliados quanto à ocorrência de EC. Seis meses após a alta, foi preenchido o questionário Short-Form-36 (SF-36 e avaliada a dependência nas atividades da vida diária (AVD. As comparações entre grupos independentes de doentes foram efetuadas com teste t de Student. A comparação entre cada variável e a ocorrência de EC foi efetuada por regressão logística envolvendo todos os doentes. RESULTADOS: Dos 1.280 doentes que apresentaram critérios de inclusão, 26 (2% desenvolveram EC. A análise univariada identificou como determinantes independentes para o desenvolvimento de EC: estado físico ASA, hipertensão arterial, doença cardíaca isquêmica, doença cardíaca congestiva e escore do Índice de Risco Cardíaco Revisado. A mortalidade seis meses após alta da UTI-Cirúrgica foi de 35%. Dos 17 sobreviventes aos seis meses, 13 completaram os questionários. Trinta e um por cento referiram que sua saúde em geral era melhor no dia em que responderam ao questionário do que 12 meses antes. Sessenta e nove por cento dos doentes estavam dependentes nas AVD instrumentais e 15%, nas AVD pessoais. CONCLUSÕES: O desenvolvimento de EC tem sério impacto no tempo de hospitalização e nas taxas de mortalidade. Seis meses após a alta da UTI-Cirúrgica, mais de metade dos doentes estavam dependentes em pelo menos uma AVD instrumental.JUSTIFICATIVA Y OBJETIVOS: Las complicaciones cardiovasculares en el postoperatorio est

  19. Epidemiological survey of graves' disease in Tianjin area

    International Nuclear Information System (INIS)

    Gao Shuo; Fang Peihua; Lai Zemin; Chen Bingzhong; Lu Tizhang; Zhou Yinbao; Tan Jian; Ni Xiaoyan

    2002-01-01

    Objective: To study the incidence of Graves' disease and associated factors. Methods: From 1997.4 to 1999.12, by using cluster and stratified sampling, total of 31530 people aged 6 years and over were surveyed epidemiologically for Graves' disease in five districts and one county of Tianjin area where the study subjects had been resided for at least one year. The researching team consisted of endocrinologists, epidemiologists and technicians and was divided into three branches, they served as investigators, professional experts and technicians, respectively. The serum thyroid hormones, thyroid antibodies, iodine in table salt, urine iodine and B-US were examined for the suspected cases, the final diagnoses were concluded by the professional experts. Results: Eighty-nine patients with Graves' disease were confirmed, 26 (0.166%) of them were males and 63(0.397%) of them were females, the total incidence was 0.282%. The incidence significantly associated with sex (female higher than male, P<0.001), age (50-60 group for male and 30-40 group for female higher than others, P<0.001) and family history (the patients with vs without family history, P<0.001). The survey showed an ascending trend of incidence of Graves' disease, along with decreasing of goiter rate and increasing of iodine contents in table salt and in urine. Further research work should be pursued. Conclusion: This study may provide some theoretical basis for prevention and treatment of Graves' disease

  20. Hickam's dictum: Myasthenia Gravis presenting concurrently with Graves' disease.

    Science.gov (United States)

    Sehgal, Shekhar; Rebello, Roshan; Wolmarans, Louise; Elston, Marianne

    2017-09-07

    We present two patients with Graves' disease and concurrent myasthenia gravis. The impact of the dual diagnosis on the clinical course and the potential for a delayed diagnosis of myasthenia gravis is discussed. Patient 1, a 28-year-old man was diagnosed with Graves' disease following his second respiratory arrest. His history was strongly suggestive of a second pathology. Patient 2, a 66-year-old Cantonese woman with established Graves' disease presented with thionamide-related neutropaenia. Examination revealed bilateral ptosis and right lateral rectus palsy. Both patients had thyrotoxicosis secondary to Graves' disease with concurrent myasthenia gravis. Although neuromuscular weakness is common in Graves' disease, coexisting myasthenia gravis (MG) is rare and can cause profound morbidity. Ocular signs in both diseases may cause diagnostic confusion although ptosis suggests coexisting MG. In both cases, the thyrotoxicosis delayed the diagnosis of MG. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  1. Vitamin D and Graves' disease: a meta-analysis update.

    Science.gov (United States)

    Xu, Mei-Yan; Cao, Bing; Yin, Jian; Wang, Dong-Fang; Chen, Kai-Li; Lu, Qing-Bin

    2015-05-21

    The association between vitamin D levels and Graves' disease is not well studied. This update review aims to further analyze the relationship in order to provide an actual view of estimating the risk. We searched for the publications on vitamin D and Graves' disease in English or Chinese on PubMed, EMBASE, Chinese National Knowledge Infrastructure, China Biology Medical and Wanfang databases. The standardized mean difference (SMD) and 95% confidence interval (CI) were calculated for the vitamin D levels. Pooled odds ratio (OR) and 95% CI were calculated for vitamin D deficiency. We also performed sensitivity analysis and meta-regression. Combining effect sizes from 26 studies for Graves' disease as an outcome found a pooled effect of SMD = -0.77 (95% CI: -1.12, -0.42; p Graves' disease were more likely to be deficient in vitamin D compared to the controls (OR = 2.24, 95% CI: 1.31, 3.81) with a high heterogeneity (I2 = 84.1%, p Graves' disease.

  2. Evolución clínica de pacientes asmáticos tratados con inmunoterapia. Municipio Majibacoa, 2008-2013

    Directory of Open Access Journals (Sweden)

    Mailin Molina Leyva

    2015-11-01

    Full Text Available Se realizó un estudio cuasi-experimental de corte longitudinal en 50 pacientes asmáticos con edades  entre 5 y 54 años, atendidos en el Servicio de Alergología del municipio Majibacoa de la provincia de Las Tunas; con el objetivo de determinar la evolución clínica con inmunoterapia, en el período de enero 2008 a febrero de 2013. A los pacientes se les administró inmunoterapia específica de ácaros con extractos estandarizados, durante tres años o más de forma subcutánea. El asma bronquial predominó en el sexo femenino y en las edades comprendidas entre 5 y 14 años. Los antecedentes de atopia familiar fueron referidos por el mayor por ciento de los pacientes analizados. Según severidad de la enfermedad, antes del tratamiento prevalecieron los pacientes en la categoría persistente moderada. Se observó mejoría de los síntomas del asma en una elevada proporción de casos.

  3. Identification of lines of electric lines of three-phase distribution networks in the composition of ASMAE

    Directory of Open Access Journals (Sweden)

    Omorov Turatbek

    2017-01-01

    Full Text Available The problem of protection of a three-phase four-wire distribution network (DEN with a voltage of 0.4 kV from the interruption of electric power lines is considered. On the basis of the analysis of the values of complex resistances of interpersonal sections of the main line of the network, criteria are proposed that allow detecting critical situations associated with discontinuities in power transmission lines. Using these criteria makes it possible to localize the places of breaks of phase and neutral wires. Mathematical models and methods that are used to evaluate the complex resistances of interpersonal sections of a three-phase network are briefly considered. The obtained results are oriented for use in the automated system of electricity control and accounting (ASMAE.

  4. Obesidade e asma: associação ou coincidência? Obesity and asthma: association or coincidence?

    Directory of Open Access Journals (Sweden)

    Daniella Fernandes Camilo

    2010-02-01

    Full Text Available OBJETIVO: A asma e a obesidade estão entre as maiores causas de morbidade na infância e adolescência. A obesidade precoce aumenta as chances de doenças crônicas degenerativas no adulto. Embora a concomitância de ambas as situações clínicas vem sendo demonstrada em vários estudos, os mecanismos intrínsecos dessa associação ainda são pouco conhecidos. Portanto, o objetivo deste artigo foi revisar os principais trabalhos sobre a associação de obesidade e asma e verificar se existe relação de causa e efeito entre ambas. FONTES DOS DADOS: Revisão sistemática baseada em bases de dados indexadas MEDLINE (PubMed e SciELO. Foram revisados artigos originais (transversal, caso-controle e prospectivo e meta-análises publicados no período de janeiro de 1998 a janeiro de 2008. Foram pesquisados estudos divulgados em língua inglesa, espanhola e portuguesa. SÍNTESE DOS DADOS: Embora existam muitos estudos sobre as crescentes prevalências da asma e da obesidade, poucos estabelecem relações de causa e efeito entre ambas. Os mecanismos fisiopatológicos e os fatores envolvidos nesse processo ainda são pouco conhecidos. CONCLUSÃO: O rigor metodológico em estudos futuros deverá buscar respostas para melhor entender se existe associação entre asma e obesidade, ou se a relação entre ambas as doenças é coincidência.OBJECTIVE: Asthma and obesity are among the major causes of morbidity in childhood and adolescence. Early obesity increases the chances of chronic degenerative diseases in adults. Although the concomitance or both clinical situations are being demonstrated in various studies, the intrinsic mechanisms of this association are still very little known. Therefore, the objective of this article was to review the main studies on the association of obesity and asthma and check if there is a cause-effect relation between them. SOURCES: Systematic review based on indexed data bases MEDLINE (PubMed and SciELO. Original articles

  5. Uso de terapias não convencionais no manejo da crise aguda de asma refratária

    OpenAIRE

    OLIVEIRA RAQUEL HERMES ROSA; RIBEIRO ALEXANDRE DE OLIVEIRA; AMARANTE GUSTAVO ADOLPHO JUNQUEIRA; TEDDE MIGUEL LIA

    2002-01-01

    Uma paciente em crise aguda de asma, refratária ao uso de beta2-agonista inalatório e intravenoso, aminofilina intravenosa e corticóide, em ventilação mecânica, foi tratada com métodos terapêuticos não convencionais: broncoscopia, lavado broncoalveolar com N-acetilcisteína e ventilação com halotano. Houve melhora dos parâmetros ventilatórios após o lavado e a resolução do broncoespasmo ocorreu após a anestesia, propiciando a extubação e alta da UTI. É feita uma revisão da literatura sobre o u...

  6. Síndrome hemofagocítico secundario a infecciones graves en un quemado

    Directory of Open Access Journals (Sweden)

    Carolina V. Mahuad

    2013-06-01

    Full Text Available El síndrome hemofagocítico constituye una entidad infrecuente, heterogénea, subdiagnosticada, y muchas veces fatal. En los casos secundarios, los desencadenantes pueden ser numerosos, tales como infecciones, fármacos, enfermedades autoinmunes y neoplasias. El mecanismo fisiopatogénico se explica por la presencia de una función disminuida o defectuosa de células NK y linfocitos T citotóxicos, que resulta en una activación inmune inefectiva y descontrolada, conduciendo al daño celular, falla multiorgánica y proliferación macrofágica con hemofagocitosis. Existen diferentes opciones terapéuticas, mayormente combinaciones de citostáticos y esteroides, cuyo objetivo es la supresión de la respuesta inmune descontrolada. Ocasionalmente, la condición clínica de algunos pacientes con síndrome hemofagocítico impide la utilización de esquemas terapéuticos intensivos. Comunicamos el caso de un paciente quemado grave, que reúne los criterios diagnósticos de síndrome hemofagocítico, quien presentó una evolución favorable con el tratamiento combinado de esteroides e inmunoglobulinas endovenosas.

  7. Towards a consensus-based biokinetic model for green microalgae - The ASM-A.

    Science.gov (United States)

    Wágner, Dorottya S; Valverde-Pérez, Borja; Sæbø, Mariann; Bregua de la Sotilla, Marta; Van Wagenen, Jonathan; Smets, Barth F; Plósz, Benedek Gy

    2016-10-15

    Cultivation of microalgae in open ponds and closed photobioreactors (PBRs) using wastewater resources offers an opportunity for biochemical nutrient recovery. Effective reactor system design and process control of PBRs requires process models. Several models with different complexities have been developed to predict microalgal growth. However, none of these models can effectively describe all the relevant processes when microalgal growth is coupled with nutrient removal and recovery from wastewaters. Here, we present a mathematical model developed to simulate green microalgal growth (ASM-A) using the systematic approach of the activated sludge modelling (ASM) framework. The process model - identified based on a literature review and using new experimental data - accounts for factors influencing photoautotrophic and heterotrophic microalgal growth, nutrient uptake and storage (i.e. Droop model) and decay of microalgae. Model parameters were estimated using laboratory-scale batch and sequenced batch experiments using the novel Latin Hypercube Sampling based Simplex (LHSS) method. The model was evaluated using independent data obtained in a 24-L PBR operated in sequenced batch mode. Identifiability of the model was assessed. The model can effectively describe microalgal biomass growth, ammonia and phosphate concentrations as well as the phosphorus storage using a set of average parameter values estimated with the experimental data. A statistical analysis of simulation and measured data suggests that culture history and substrate availability can introduce significant variability on parameter values for predicting the reaction rates for bulk nitrate and the intracellularly stored nitrogen state-variables, thereby requiring scenario specific model calibration. ASM-A was identified using standard cultivation medium and it can provide a platform for extensions accounting for factors influencing algal growth and nutrient storage using wastewater resources. Copyright

  8. Transient hypothyroidism after 131I treatment of Graves disease

    International Nuclear Information System (INIS)

    Liu Jianfeng; Fang Yi; Zhang Xiuli; Ye Genyao; Xing Jialiu; Zhang Youren

    2003-01-01

    Objective: To evaluate the results of the transient hypothyroidism after 131 I treatment of Graves disease. Methods: A total of 32 transient hypothyroidism patients treated with 131 I for Graves disease were studied and followed up. Results: Transient hypothyroidism occurred within 2-6 months after 131 I treatment and 19 patients were symptomatic. At diagnosis of transient hypothyroidism, T 3 and T 4 levels were decreased had normal, TSH levels were increased, normal or low. Follow-up examination found that 20 patients were normal and 12 patients had relapse of hyperthyroidism. Conclusions: Therapy of Graves disease with low doses of 131 I causes a high incidence of transient hypothyroidism. After recovery of transient hypothyroidism, some patients have relapse of hyperthyroidism

  9. Radiation retinopathy after orbital irradiation for Graves' ophthalmopathy

    International Nuclear Information System (INIS)

    Kinyoun, J.L.; Kalina, R.E.; Brower, S.A.; Mills, R.P.; Johnson, R.H.

    1984-01-01

    Recent reports indicate that orbital irradiation for Graves' ophthalmopathy is sometimes beneficial, particularly for dysthyroid optic neuropathy, and is not associated with serious complications. We are aware, however, of four patients who were found to have radiation retinopathy after orbital irradiation for Grave's ophthalmopathy. All four patients have decreased central acuity, and three of the four are legally blind in one or both eyes. Computer reconstruction of the dosimetry, based on computed tomography and beam profiles, shows that errors in dosage calculations and radiotherapy technique probably account for the radiation retinopathy in three of the four patients. Radiotherapy for Graves' ophthalmopathy should be administered only by competent radiotherapists who are experienced in the treatment of this disease. Similar errors in dosage calculations and treatment techniques may account for other reports of radiation retinopathy after reportedly safe dosages

  10. Esclerodermia, tireoidite e miastenia grave: estudo de um caso

    Directory of Open Access Journals (Sweden)

    Antonio L. dos Santos Werneck

    1993-11-01

    Full Text Available Uma paciente de 36 anos com miastenia grave desenvolveu após dois anos intolerância ao frio, o que conduziu ao diagnóstico de tireoidite de Hashimoto. Quatro anos mais tarde apresentou pele espessada nas mãos (esclerodermia limitada. O quadro clínico e os exames complementares encaminharam o diagnóstico para a forma CREST de esclerodermia sistêmica progressiva. Discute-se a dificuldade diagnóstica da esclerodermia, assim como suas síndromes de superposição. Doença de Hashimoto e miastenia grave constituem associação pouco frequente. A presença de esclerodermia e miastenia grave é rara. Não encontramos na literatura a coincidência destas três doenças.

  11. Clinical experience of radiation therapy for Graves` ophthalmopathy

    Energy Technology Data Exchange (ETDEWEB)

    Takahashi, Takeo; Mitsuhashi, Norio; Nagashima, Hisako; Sakurai, Hideyuki; Murata, Osamu; Ishizeki, Kei; Shimaya, Sanae; Hayakawa, Kazushige; Niibe, Hideo [Gunma Univ., Maebashi (Japan). School of Medicine

    1996-11-01

    The effect of radiation therapy for Graves` ophthalmopathy was evaluated. Ten patients with Graves` ophthalmopathy were treated with radiation therapy between 1992 and 1993 in Gunma University Hospital. All patients had a past history of hyperthyroidism and received 2,000 cGy to the retrobulbar tissues in 20 fractions. Nine of ten patients were treated with radiation therapy after the failure of corticosteroids. Six patients (60%) showed good or excellent responses. The exophthalmos type was more responsive to radiation therapy than the double vision type in this series. Two of five patients with the exophthalmos type demonstrated excellent responses, and their symptoms disappeared almost completely. The improvement of symptoms appeared within 3-6 months, and obvious clinical effects were demonstrated after 6 months of radiotherapy. Radiation therapy was well tolerated, and we have not observed any side effects of radiation therapy. In conclusion, radiation therapy is effective treatment for Graves` ophthalmopathy. (author)

  12. Clinical experience of radiation therapy for Graves' ophthalmopathy

    International Nuclear Information System (INIS)

    Takahashi, Takeo; Mitsuhashi, Norio; Nagashima, Hisako; Sakurai, Hideyuki; Murata, Osamu; Ishizeki, Kei; Shimaya, Sanae; Hayakawa, Kazushige; Niibe, Hideo

    1996-01-01

    The effect of radiation therapy for Graves' ophthalmopathy was evaluated. Ten patients with Graves' ophthalmopathy were treated with radiation therapy between 1992 and 1993 in Gunma University Hospital. All patients had a past history of hyperthyroidism and received 2,000 cGy to the retrobulbar tissues in 20 fractions. Nine of ten patients were treated with radiation therapy after the failure of corticosteroids. Six patients (60%) showed good or excellent responses. The exophthalmos type was more responsive to radiation therapy than the double vision type in this series. Two of five patients with the exophthalmos type demonstrated excellent responses, and their symptoms disappeared almost completely. The improvement of symptoms appeared within 3-6 months, and obvious clinical effects were demonstrated after 6 months of radiotherapy. Radiation therapy was well tolerated, and we have not observed any side effects of radiation therapy. In conclusion, radiation therapy is effective treatment for Graves' ophthalmopathy. (author)

  13. An update on the medical treatment of Graves' hyperthyroidism.

    Science.gov (United States)

    Marinò, Michele; Latrofa, Francesco; Menconi, Francesca; Chiovato, Luca; Vitti, Paolo

    2014-11-01

    Medical treatment of Graves' hyperthyroidism is based on the use of thionamides; namely, methimazole and propylthiouracil. In the past, methimazole was preferred by European endocrinologists, whereas propylthiouracil was the first choice for the majority of their North American colleagues. However, because of the recent definition of a better side-effect profile, methimazole is nowadays the first choice world while. Although thionamides are quite effective for the short-term control of Graves' hyperthyroidism, a relatively high proportion of patients relapses after thionamide withdrawal. Other possible medical treatments, include iodine and compounds containing iodine, perchlorate, lithium (as an adjuvant in patients undergoing radioiodine therapy), β-adrenergic antagonists, glucocorticoids, and some new molecules still under investigation. Management of Graves' hyperthyroidism using thionamides as well as the other available medical treatments is here reviewed in detail, with a special mention of situations such as pregnancy and lactation, as well as neonatal and fetal thyrotoxicosis.

  14. F-18-FDG PET of the thyroid in Graves' disease

    International Nuclear Information System (INIS)

    Boerner, A.R.; Voth, E.; Schicha, H.; Wienhard, K.; Wagner, R.

    1998-01-01

    This study evaluates F-18-FDG PET of the thyroid in Graves' disease. Methods: Thirty patients were investigated the day before radioiodine therapy, 15 patients 3-10 days after radioiodine therapy. Twenty patients with cancer of the head or neck and normal thyroid function served as controls. Results: F-18-FDG uptake was higher in Graves' disease patients than in controls. Negative correlations of F-18-FDG uptake with half-life of radioiodine and absorbed radiation dose due to radioiodine therapy were found along with a positive correlation to autoantibody levels. Conclusion: Thus F-18-FDG PET is likely to give information on the biological activity of Graves' disease as well as on early radiation effects. (orig.) [de

  15. A case of severe autoimmune hepatitis associated with Graves' disease

    Directory of Open Access Journals (Sweden)

    Samia Abdulla Bokhari

    2016-01-01

    Full Text Available Graves' disease is a common condition and is known to have a wide range of effects on a variety of organs. Hepatic dysfunction ranging from mild to severe due to direct effect of high circulating thyroid hormones as well as a deleterious effect of antithyroid medications (methimazole and propylthiouracil has been well - documented in literature. However, severe autoimmune hepatitis (AIH associated with Graves' disease is rare and limited to few case reports only. A 38-year-old woman presented with abdominal pain and yellowish discolouration of conjunctivae. On investigation, she was found to have Graves' disease and AIH. The liver histopathology showed typical features of AIH. She responded excellently to glucocorticoid therapy with normalisation of thyroid function and liver histology. The case is discussed with relevant literature review.

  16. Prevalência de asma em escolares Prevalence of asthama in schoolchildren

    Directory of Open Access Journals (Sweden)

    Antonio J. Amorim

    2001-06-01

    Full Text Available OBJETIVO: avaliar a prevalência dos sintomas e da doença de asma em crianças, em razão da alta freqüência de pacientes pediátricos com sintomas sugestivos da doença e da falta de dados de prevalência nesta população. MÉTODOS: Num estudo transversal, foram avaliados 2.735 escolares na faixa etária de 6-7 anos (crianças e 3.509 na de 13-14 anos (adolescentes, escolhidos por amostragem aleatória. Os dados foram coletados em 1998-99 utilizando-se o questionário escrito traduzido do International Study of Asthma and Allergies in Children (ISAAC, previamente testado e validado. O questionário dirigido às crianças foi respondido pelos seus responsáveis, enquanto os adolescentes responderam em sala de aula. Os dados foram transcritos e analisados pelo programa EPI-info. RESULTADOS: Taxa de devolução: 73,2% (6-7 anos e 94% (13-14 anos. Prevalência dos sintomas nas crianças e adolescentes: sibilos alguma vez, 46,7% e 44,3% (p OBJECTIVE: to assess the prevalence of asthma symptoms and of asthma in children due to the high frequency of pediatrics patients with symptoms suggestive of the disease and to the lack of data regarding prevalence of asthma in this population. METHODS: We carried out a cross-sectional study with 2,735 school-age children aged 6-7 years and 3,509 adolescents aged 13-14 years selected by random sampling. Data were collected between 1998 and 1999 using a translated version of the questionnaire of the International Study of Asthma and Allergies in Children, which has been previously tested and approved. Guardians were responsible for answering the questionnaire of younger children, whereas adolescents answered their own, in classroom. The data were computed and analyzed using EPI-info software. RESULTS: The response rates for questionnaires were 73.2% (6-7-years old and 94% (13-14 years old. The prevalence of symptoms in children and adolescents were, respectively: wheezing ever 46.7% and 44.3% (P<0.05; wheezing

  17. Graves' Disease Pharmacotherapy in Women of Reproductive Age.

    Science.gov (United States)

    Prunty, Jeremy J; Heise, Crystal D; Chaffin, David G

    2016-01-01

    Graves' disease is an autoimmune disorder in which inappropriate stimulation of the thyroid gland results in unregulated secretion of thyroid hormones resulting in hyperthyroidism. Graves' disease is the most common cause of autoimmune hyperthyroidism during pregnancy. Treatment options for Graves' disease include thioamide therapy, partial or total thyroidectomy, and radioactive iodine. In this article, we review guideline recommendations for Graves' disease treatment in women of reproductive age including the recent guideline from the American College of Obstetricians and Gynecologists. Controversy regarding appropriate thioamide therapy before, during, and after pregnancy is reviewed. Surgical and radioactive iodine therapy considerations in this patient population are also reviewed. In patients who may find themselves pregnant during therapy or develop Graves' disease during their pregnancy, consideration should be given to the most appropriate treatment course for the mother and fetus. Thioamide therapy should be used with either propylthiouracil or methimazole at appropriate doses that target the upper range of normal to slightly hyperthyroid to avoid creating hypothyroidism in the fetus. Consideration should also be given to the adverse effects of thioamide, such as agranulocytosis and hepatotoxicity, with appropriate patient consultation regarding signs and symptoms. Individuals who wish to breastfeed their infants while taking thioamide should receive the lowest effective dose. Surgery should be reserved for extreme cases and limited to the second trimester, if possible. Radioactive iodine therapy may be used in nonpregnant individuals, with limited harm to future fertility. Radioactive iodine therapy should be withheld in pregnant women and those who are actively breastfeeding. Clinicians should keep abreast of developments in clinical trials and evidence-based recommendations regarding Graves' disease in reproductive-age women for any changes in evidence

  18. Serum immunoglobulin G4 levels and Graves' disease phenotype.

    Science.gov (United States)

    Martin, Carmen Sorina; Sirbu, Anca Elena; Betivoiu, Minodora Andreea; Florea, Suzana; Barbu, Carmen Gabriela; Fica, Simona Vasilica

    2017-02-01

    We investigated, at diagnosis, the relationship between serum immunoglobulin G4 levels and the main characteristics of Graves' disease: hyperthyroidism severity, goiter size, presence of active Graves' ophthalmopathy, antithyroid antibodies status, and titer. This prospective study included 80 newly diagnosed Graves' disease patients. The main parameters measured at diagnosis: thyroid-stimulating hormone, free thyroxine, free triiodothyronine, total triiodothyronine, thyroglobulin, antithyroid peroxidase antibodies, anti-thyroglobulin antibodies, thyroid-stimulating hormone receptor antibodies, immunoglobulin G4. In Graves' disease patients, serum immunoglobulin G4 levels were higher than in general population (p = 0.028) and higher in men compared to women (p = 0.002). Only one female patient with intense hypoechoic goiter, high anti-thyroglobulin antibody, and antithyroid peroxidase antibody titers had an elevated serum immunoglobulin G4 level at diagnosis. Patients with immunoglobulin G4 levels above the 75th percentile (>237.52 mg/dl, N = 20) were younger at Graves' ophthalmopathy onset (p 286.28 mg/dl, N = 8) had lower total triiodothyronine values (p = 0.001) than patients with IgG below the 90th percentile. No significant correlations were found between smoking status (p = 0.58), goiter size (p = 0.50), the presence of ophthalmopathy (p = 0.42) or thyroid-stimulating hormone receptor antibody titers (p = 0.45) and the mean value of immunoglobulin G4 levels at diagnosis. Our data suggest that Graves' disease patients with elevated immunoglobulin G4 levels at diagnosis have a phenotype characterized by higher anti-thyroglobulin antibody and antithyroid peroxidase antibody titers, less severe T3 hyperthyroidism, younger age at ophthalmopathy onset and require a shorter duration of the first methimazole treatment cycle.

  19. Thyroid Ultrasonography in Differentiation between Graves' Disease and Hashimoto's Thyroiditis.

    Science.gov (United States)

    Pishdad, P; Pishdad, G R; Tavanaa, S; Pishdad, R; Jalli, R

    2017-03-01

    Graves' disease and Hashimoto's thyroiditis are the most common causes of hyper and hypothyroidism, respectively. Differentiation of these 2 diseases, if the patient is euthyroid, may sometimes be extremely difficult on the basis of clinical and laboratory findings. The purpose of this study was to determine the sensitivity and specificity of gray scale sonography in differentiation of Graves' disease from Hashimoto's thyroiditis. This study included 149 patients divided into three groups, patients with Graves' disease (34 patients, mean age = 36.8 ± 10.17 years), Patients with Hashimoto's thyroiditis (62 patients, mean age = 33.4 ± 12.16 years) and control group (53 healthy people, mean age = 34.74 ± 16.87 years). Members of all groups were referred to a single radiologist for thyroid sonography for evaluation of thyroid echogenicity pattern. A total of 117 women and 32 men were examined by sonography. The most common sonographic pattern in Hashimoto and Graves' was homogenous hypo-echogenicity which was observed in 45.2% and 47.1% of cases, respectively. Peripheral hypo-echogenicity pattern was seen in 40.3% of Hashimoto's group with 100% specificity and 40.3% sensitivity. Central-hypoechogenic pattern was observed in 17.6% of Graves' group with 100% and 17.6% specificity and sensitivity, respectively. Our findings indicate that sonography has high specificity but low sensitivity in the diagnosis of either Graves' disease or Hashimoto's thyroiditis. It is therefore not possible to differentiate between these two diseases using sonography alone. Confirmation by laboratory data is also needed.

  20. La enfermedad de Graves, signos y síntomas

    OpenAIRE

    Young, P.; Finn, B. C.; Bruetman, J. E.

    2007-01-01

    La enfermedad de Graves es la causa más común de hipertiroidismo, es de patogenia autoinmune. Se distingue clínicamente de otras formas de hipertiroidismo por la presencia de bocio difuso, oftalmopatía y ocasionalmente mixedema pretibial. En este artículo describimos la vida y obra de Robert Graves, realizando posteriormente una revisión de los signos y síntomas de la enfermedad. En el mundo de la medicina actual, en donde la tecnología juega un rol preponderante, queremos recordar la importa...

  1. Dissociative disorder due to Graves' hyperthyroidism: a case report.

    Science.gov (United States)

    Mizutani, Kaoru; Nishimura, Katsuji; Ichihara, Atsuhiro; Ishigooka, Jun

    2014-01-01

    We report the case of a 20-year-old Japanese woman with no psychiatric history with apparent dissociative symptoms. These consisted of amnesia for episodes of shoplifting behaviors and a suicide attempt, developing together with an exacerbation of Graves' hyperthyroidism. Patients with Graves' disease frequently manifest various psychiatric disorders; however, very few reports have described dissociative disorder due to this disease. Along with other possible causes, for example, encephalopathy associated with autoimmune thyroid disease, clinicians should be aware of this possibility. Copyright © 2014 Elsevier Inc. All rights reserved.

  2. Treating the thyroid in the presence of Graves' ophthalmopathy

    DEFF Research Database (Denmark)

    Hegedüs, Laszlo; Bonnema, Steen J; Smith, Terry J

    2012-01-01

    The etiology of Graves' orbitopathy (GO) remains enigmatic. Optimal therapeutic choices for the hyperthyroidism associated with Graves' disease (GD) in the presence of GO remain controversial. Whether antithyroid drugs (ATDs), radioiodine (RAI), or thyroidectomy should be favored in such patients...... - independent of extent - do not influence the natural course of GO. RAI can cause de novo development or progression of GO, which is largely preventable with oral steroid prophylaxis. In patients with mild GO, the thyroid treatment is largely independent of GO. Moderate to severe GO should be treated promptly...

  3. Graves' disease presenting as pseudotumor cerebri: a case report

    Directory of Open Access Journals (Sweden)

    Freitas Cláudia

    2011-02-01

    Full Text Available Abstract Introduction Pseudotumor cerebri is an entity characterized by elevated intracranial pressure with normal cerebrospinal fluid and no structural abnormalities detected on brain MRI scans. Common secondary causes include endocrine pathologies. Hyperthyroidism is very rarely associated and only three case reports have been published so far. Case presentation We report the case of a 31-year-old Luso-African woman with clinical symptoms and laboratory confirmation of Graves' disease that presented as pseudotumor cerebri. Conclusion This is a rare form of presentation of Graves' disease and a rare cause of pseudotumor cerebri. It should be remembered that hyperthyroidism is a potential cause of pseudotumor cerebri.

  4. CT volumetric measurements of the orbits in Graves' disease

    International Nuclear Information System (INIS)

    Krahe, T.; Schlolaut, K.H.; Poss, T.; Trier, H.G.; Lackner, K.; Bonn Univ.; Bonn Univ.

    1989-01-01

    The volumes of the four recti muscles and the orbital fat was measured by CT in 40 normal persons and in 60 patients with clinically confirmed Graves' disease. Compared with normal persons, 42 patients (70%) showed an increase in muscle volume and 28 patients (46.7%) an increase in the amount of fat. In nine patients (15%) muscle volume was normal, but the fat was increased. By using volumetric measurements, the amount of fat in the orbits in patients with Graves' disease could be determined. (orig.) [de

  5. Facts and fallacies about radioactive iodine therapy for Graves' disease

    International Nuclear Information System (INIS)

    Miller, J.L.

    1982-01-01

    The therapeutic options available in the hyerthyroidism of Graves' disease are two basic treatments. Firstly antithyroid drugs and secondly one can 'ablate' the thyroid gland by means of thyroidectomy or radioactive iodine ( 131 I). At present 131 I is the current treatment of chioce for Graves' disease. In a follow-up study of 21 714 patients who were treated with 131 I and observed for a period of 8 years, there was no increase in the incidence of thyriod carcinoma. A possible explanation for this is that the dose of 131 I used destroys the ability of the thyroid cells to replicate and thus transmit genetically damaged material

  6. Severe aplastic anaemia and Grave's disease in a paediatric patient.

    Science.gov (United States)

    Kumar, Manjusha; Goldman, Jeffrey

    2002-07-01

    Severe aplastic anaemia (SAA) is considered to be an autoimmune disorder affecting the haematopoietic cells and most often is idiopathic. An association between SAA and other autoimmune diseases is rare and has been described in adults for eosinophilic fasciitis, thymomas, systemic lupus erythematosus and thyroid disorders. We describe the first paediatric patient with chronic relapsing SAA and Grave's disease. We discuss the difficulty in diagnosis of Grave's disease, the possibility of its manifestation due to withdrawal of immunosuppressants, and issues to consider in the treatment of this disease in the setting of bone marrow failure.

  7. Graves' ophthalmopathy evaluated by infrared eye-movement recordings

    International Nuclear Information System (INIS)

    Feldon, S.E.; Unsoeld, R.

    1982-01-01

    Thirteen patients with varying degrees of Graves' ophthalmopathy were examined using high-resolution infrared oculography to determine peak velocities for horizontal eye movements between 3 degrees and 30 degrees. As severity of the orbital disease increased, peak velocities became substantially lower. Vertical-muscle surgery failed to have any effect on peak velocity of horizontal eye movements. In contrast, orbital decompression caused notable improvement in peak velocity of eye movements. Eye-movement recordings, which provide a measure of extraocular muscle function rather than structure, may provide a safe, sensitive, and accurate method for classifying and following up patients with Graves' ophthalmopathy

  8. ALGUNAS ALTERACIONES HISTOPATOLÓGICAS RELACIONADAS CON ENFERMEDADES DEL SISTEMA INMUNE

    Directory of Open Access Journals (Sweden)

    Ángel Concepción

    2011-01-01

    Full Text Available El estudio del sistema inmune normal y los efectos histopatológicos provocados por sus alteraciones, son de la mayor importancia tanto desde el punto de vista investigativo, como para una adecuada preparación del médico integral que se necesita formar en este campo. Tomando en consideración estos antecedentes fue utilizado en el presente trabajo, muestras de mastocitos peritoneales teñidas con azul de toluidina y cortes de corazón, pulmón y tiroides, incluidas en parafina y teñidas con hematoxilina-eosina. Posteriormente fueron fotografiadas a través de un microscopio óptico y procesadas, mediante un programa de foto edición. Se comparan patologías de origen inmunológico, como las características de los mastocitos desgranulados y sin desgranular, corazón normal y con carditis, pulmón normal con la de asma a nivel alveolar y tiroides normal, con tiroiditis. El objetivo del trabajo consiste en comparar un grupo de imágenes que muestran las características normales de diversos órganos, comparándolas con las imágenes de patologías de origen inmunológico que las afectan, por lo que además del resultado investigativo, posee valor docente.

  9. Evaluación de los comportamientos adictivos en personas con enfermedad mental grave y prolongada

    OpenAIRE

    Martín Domínguez, María

    2017-01-01

    Trabajo Fin de Master curso 2016/2017 [EN] Along the next pages, a descriptive, transversal, retrospective and factorial study is developed with the main goal of assessing the addictive behavior in a sample of n=21 patients with a serious and prolonged illness (schizophrenia spectrum disorder, other psychotic disorders and bipolar disorder) hospitalized at Unit of Psychiatry Acute related to the Provincial Hospital of Zamora. Another aim of this study is to describe the relationships betwe...

  10. A controlled monitoring study of simulated clandestine graves using 3D ground penetrating radar

    CSIR Research Space (South Africa)

    van Schoor, Michael

    2017-06-01

    Full Text Available A controlled three-dimensional ground penetrating radar monitoring study over simulated clandestine graves was conducted near Pretoria, South Africa, in which the detectability of graves as a function of post-burial interval was assessed...

  11. Genotypes in relation to phenotypic appearance and exposure to environmental factors in Graves' hyperthyroidism

    NARCIS (Netherlands)

    Vos, Xander G.; Endert, Erik; Tijssen, Jan G. P.; Wiersinga, Wilmar M.

    2012-01-01

    Background: Genetic polymorphisms and environmental factors are both involved in the pathogenesis of Graves' disease, but their interaction and effect on Graves' phenotypes have scarcely been investigated. Objective: To test the hypothesis that subjects with susceptibility genotypes develop more

  12. Condilomatosis vulvar grave Severe vulvar condyloma

    Directory of Open Access Journals (Sweden)

    Idalberto Clavijo Balart

    Full Text Available Se describe el caso clínico de una paciente que desde hacía 9 años presentaba numerosas verrugas en la vulva, además de prurito y dolor ocasional, más frecuentes al realizar determinadas actividades. Se efectuó vulvectomía simple y se comprobó la presencia de cambios típicos coilocíticos, de modo que no se trataba de lesiones malignas. Resultó imposible determinar el virus del papiloma humano, aunque por las manifestaciones clínicas podía corresponder a las cepas 6 y 11. La fémina fue egresada sin elementos de infección local, con tejido de granulación útil y compensada metabólicamente, pero con seguimiento por consulta externa hasta los 3 meses de operada.A case report of a patient who presented with numerous warts in her vulva for 9 years besides pruritus and occasional pain is described, more frequent when she was doing certain activities. Simple vulvectomy was performed and the presence of typical koilocytotic changes was confirmed, but there were not malignant lesions. It was impossible to determine the human papilloma virus, although by its clinical manifestations could be strains 6 and 11. The patient was discharged metabolically compensated with useful granulation tissue and without local infection, but she was followed for 3 months after surgery in the outpatient department.

  13. Auto-estima na forma inativa da oftalmopatia de Graves Inactive Graves' ophthalmopathy and self-esteem

    Directory of Open Access Journals (Sweden)

    Carlos Henrique de Toledo Magalhães

    2008-04-01

    Full Text Available OBJETIVOS: Avaliar a auto-estima dos pacientes com oftalmopatia de Graves na fase inativa. MÉTODOS: Foram avaliados 30 pacientes portadores de oftalmopatia de Graves, eutireoideanos, na fase inativa, com idade variando entre 26 e 65 anos, média 43 ± 11,0 anos, denominado grupo estudo e 39 indivíduos que não apresentavam oftalmopatia de Graves, com idade variando entre 18 e 67 anos, média de 41 ± 13,4 anos, selecionados na população geral denominado grupo controle. Para avaliar a auto-estima foi utilizada a escala de auto-estima Rosenberg Unifesp-EPM aplicada por meio de entrevista. Os valores dos escores de auto-estima nos dois grupos estudados foram comparados pelo teste não paramétrico de Mann-Whitney. O mesmo teste foi aplicado com objetivo de comparar os resultados obtidos no grupo oftalmopatia de Graves considerando a gravidade da doença. RESULTADOS: Não foi observada alteração com significância estatística na auto-estima dos pacientes com oftalmopatia de Graves (p=0,057. O grupo estudo apresentou, em média, valores inferiores de auto-estima, comparado ao grupo controle. Não houve diferença da auto-estima entre os pacientes dos subgrupos leve e moderado-grave (P=0,2710. CONCLUSÃO: A oftalmopatia de Graves na fase inativa não afetou a auto-estima dos pacientes, no grupo estudado.PURPOSE: To assess the self-esteem of Graves' ophthalmopathy patients in the inactive phase. METHODS: Thirty euthyroid patients were evaluated in the inactive phase of disease with age ranging from 26 to 65 years, average of 43 ± 11,0 years, called study group and 39 individuals without Graves' ophthalmopathy with age ranging from 18 to 67 years, average of 41 ± 13,4 years, selected from the general population called control group. To evaluate the self-esteem the Rosenberg UNIFESP/EPM self-esteem scale, applied by means of an interview, was utilized. The self-esteem scores in the two studied groups were compared by means of the non

  14. Injuria renal aguda en la sepsis grave Acute kidney injury in severe sepsis

    Directory of Open Access Journals (Sweden)

    Hernán Trimarchi

    2009-06-01

    Full Text Available La sepsis afecta al 40% de los pacientes críticos, siendo su mortalidad de aproximadamente un 30% en el caso de la sepsis grave, y de 75% con injuria renal aguda, la cual sucede en el 20-51% de los casos. Se realizó un estudio prospectivo, observacional, longitudinal, en 80 pacientes sépticos graves en el lapso de 1 año para determinar el desarrollo de injuria renal aguda y su relación con la mortalidad; correlacionar antecedentes clínicos y variaciones del laboratorio con la mortalidad; determinar la tasa de mortalidad de la sepsis grave; relacionar óbito y foco séptico primario; evaluar la predictibilidad de mortalidad según niveles de creatinina de ingreso y sus variaciones finales. Se definieron dos grupos: Obito (n = 25 y No-óbito (n = 55. Analizados según la creatinina de ingreso, 39 tenían valores normales de creatinina (10 óbitos y 41 la presentaban elevada (15 óbitos; según la creatinina de egreso, 48 presentaron creatinina normal y fallecieron 7, mientras que 32 tenían daño renal agudo, de los cuales 18 fallecieron. De los 25 pacientes fallecidos, el 72% presentaron daño renal. De éstos, 7 pacientes vivos y 2 fallecidos requirieron hemodiálisis. El foco primario más frecuente fue el respiratorio (26.4%. El desarrollo de daño renal es un alto predictor de mortalidad en la sepsis, independientemente de los valores iniciales de creatinina. Edad más avanzada, hipertensión arterial, score APACHE más elevado, anemia más grave, hipoalbuminemia, hiperfosfatemia e hiperkalemia se asociaron a mayor mortalidad. La mortalidad global fue 31.3%. La imposibilidad de identificar el foco séptico primario se asoció a mayor mortalidad. El foco respiratorio se relacionó a mayor riesgo de requerir hemodiálisis.Sepsis affects 40% of critically ill patients, with a reported mortality of approximately 30% in severe sepsis, raising to 75% when acute kidney injury ensues, which occurs in about 20-51% of cases. The present study

  15. HIV PREVENTION RESEARCH AMONG SEVERELY MENTALLY ILL LATINAS: AN EXAMINATION OF ETHICAL ISSUES IN THE CONTEXT OF GENDER AND CULTURE LA INVESTIGACIÓN DE LA PREVENCIÓN DE VIH EN MUJERES LATINAS CON ENFERMEDAD MENTAL GRAVE: EVALUACIÓN DE CUESTIONES ÉTICAS EN EL CONTEXTO DEL GÉNERO Y LA CULTURA PESQUISA SOBRE A PREVENÇÃO DO HIV EM MULHERES LATINAS COM ENFERMIDADE MENTAL GRAVE: UM EXAME DE QUESTÕES ÉTICAS NO CONTEXTO DO GÊNERO E DA CULTURA

    Directory of Open Access Journals (Sweden)

    Sana Loue

    2007-06-01

    Full Text Available We examine the interplay between ethical issues, gender, and culture in the context of our study which examines the context of HIV risk among Puerto Rican and Mexican women with schizophrenia, bipolar disorder, and major depression. Culture and gender are considered in the evaluation of ethical questions related to scientific issues, research team issues, analysis of risks and benefits of participating, confidentiality of data and privacy of the study participants, selection and recruitment, informed consent and decisional capacity, incentives, institutional and peer review matters, data presentation, and community needs. Ethical obligations to research participants and the relevant community are discussedEl presente estudio examina la interrelación entre los temas éticos, el género y la cultura en el contexto de riesgo a VIH en mujeres de Puerto Rico y México con esquizofrenia, trastorno bipolar y depresión mayor. El género y la cultura se consideran en la evaluación de las cuestiones éticas sobre temas científicos, equipo de investigación, análisis de riesgos y beneficios por participar, confidencialidad y privacidad de datos de los participantes, selección y reclutamiento, consentimiento informado y capacidad de tomar decisiones, incentivos, cuestiones institucionales y de evaluación por pares, presentación de información y necesidades de la comunidad. Se discuten las obligaciones éticas para con los participantes en el estudio y la comunidad relevanteO presente estudo examina a interrelação, dentre os temas éticos, do gênero e da cultura em um contexto de risco ao HIV, junto a mulheres portadoras de esquizofrenia, transtorno bipolar e depressão profunda, de Porto Rico e México.O gênero e a cultura foram avaliados tendo em vista questões éticas sobre temas científicos como, equipe de pesquisa, análise de riscos e benefícios por participação, confidencialidade e privacidade dos dados dos participantes, seleção e

  16. Avaliação de dois anos de um programa educacional para pacientes ambulatoriais adultos com asma Two-year evaluation of an educational program for adult outpatients with asthma

    Directory of Open Access Journals (Sweden)

    Luciene Angelini

    2009-07-01

    Full Text Available OBJETIVO: Avaliar o conhecimento da doença e a melhora clínica de portadores de asma persistente moderada e grave antes e após a sua participação em um programa de educação realizado durante as visitas ambulatoriais de rotina. MÉTODOS: Trata-se de um estudo piloto, prospectivo que envolveu 164 pacientes durante um período de dois anos. O programa de educação, oferecido para pequenos grupos nos dias de consulta, consistiu de aulas expositivas divididas em três módulos: fisiopatologia, controle ambiental e tratamento, incluindo o treinamento da técnica inalatória. Para a avaliação do programa, foram utilizados questionários padronizados sobre a melhora clínica e conhecimento da doença. RESULTADOS: Em um ano, 120 pacientes completaram três visitas, e 51 pacientes foram reavaliados em dois anos. A média de idade dos pacientes foi de 44 anos, 70% eram do sexo feminino, e 43% tinham até oito anos de educação formal. A intervenção educacional aumentou o conhecimento da doença de forma significativa (p OBJECTIVE: To evaluate the understanding of asthma and the clinical improvement in patients with moderate or severe persistent asthma prior to and after their participation in an educational program presented during the routine outpatient visits. METHODS: This was a prospective pilot study involving 164 patients over a two-year period. The educational program, presented to small groups on outpatient visit days, consisted of lectures divided into three parts: pathophysiology; environmental control; and treatment, including training in the inhalation technique. The program was evaluated using standardized questionnaires on clinical improvement and understanding of the disease. RESULTS: By the end of the first year, 120 patients had completed three visits, and 51 of those patients were revaluated at the end of the second year. The mean age of the patients was 44 years, 70% were female, and 43% had up to eight years of schooling

  17. Estimativa do custo da asma em tratamento ambulatorial especializado em unidade universitária no Sistema Único de Saúde

    OpenAIRE

    Eduardo Costa de Freitas Silva

    2014-01-01

    A asma é considerada um problema de saúde pública mundial. É necessário expandir o conhecimento sobre seus custos associados em diferentes regiões. O principal objetivo foi estimar os custos do tratamento da asma em uma população de asmáticos com diferentes níveis de gravidade, sob tratamento ambulatorial especializado. Os objetivos secundários foram analisar as características clínicas e sócio-econômicas da população e o custo incremental da associação com a rinite e infecções respiratórias ...

  18. Asthma cases in childhood attributed to atopy in tropical area in Brazil Asma infantil atribuida a atopia en la zona tropical de Brasil

    Directory of Open Access Journals (Sweden)

    Sergio Souza da Cunha

    2010-12-01

    Full Text Available OBJECTIVE: This study aimed to explore the association between asthma and atopy in a cohort of children living in a large urban center in Brazil. Atopy was defined by the presence of allergen-specific IgE in serum or by a positive skin prick test. METHODS: In a sample of 1 445 Brazilian children, the association between the prevalence of asthma, skin prick test positivity, and allergen-specific IgE in serum was investigated. RESULTS: The prevalence of asthma was 22.6%. The presence of serum allergen-specific IgE was frequent in asthmatics and nonasthmatics, and the prevalence of asthma increased only with levels of allergen-specific IgE > 3.5 kilounits/L. The proportion of asthma attributable to atopy was estimated to be 24.5% when atopy was defined by the presence of allergen-specific IgE. With a given level of specific IgE, no association between skin test reactivity and asthma was observed. Skin prick tests were less sensitive than specific IgE for detection of atopy. CONCLUSIONS: Most asthma cases in an urban underprivileged setting in Brazil were not attributable to atopy. This observation has important implications for understanding the risk factors for the asthma epidemic in Latin AmericaOBJETIVO: Explorar la relación entre el asma y la atopia en una cohorte de niños que viven en un gran centro urbano de Brasil. En este estudio, se considera atopia la detección de IgE sérica específica de algún alérgeno o un resultado positivo a la prueba de punción cutánea. MÉTODOS: Se estudió la relación entre la prevalencia del asma, el resultado positivo a la prueba de punción cutánea y la detección de IgE sérica específica de algún alérgeno en una muestra de 1 445 niños brasileños. RESULTADOS: El asma registró una prevalencia de 22,6%. La presencia de IgE séricas específicas de alérgenos fue frecuente tanto en los asmáticos como en los no asmáticos, y la prevalencia del asma fue mayor solo cuando el valor detectado de la Ig

  19. Salbutamol inhalado o nebulizado en el tratamiento de la exacerbación aguda del asma en el preescolar: estudio comparativo aleatorizado. Inhaled vs nebulized salbutamol in the management of acute asthma exacerbation in preschool children: a randomized comparative trial

    Directory of Open Access Journals (Sweden)

    María de la Luz Valencia Chávez

    1999-03-01

    Full Text Available Con el objetivo de evaluar la eficacia y seguridad del salbutamol inhalado en comparación con el nebulizado, en niños de uno a seis años de edad, se diseñó un ensayo clínico aleatorizado en 70 casos que consultaron en un período de seis meses al Hospital Infantil Arzobispo Caycedo de la ciudad de Medellín, Colombia, por presentar una exacerbación aguda de asma. Se suministraron al grupo inhalado compuesto por 32 niños, dos disparos de 100 mg de salbutamol, mediante una inhalocámara de polietileno de fabricación casera y de 500 ml de capacidad, por tres oportunidades separadas entre sí veinte minutos. A los 38 pacientes nebulizados, se les administraron 0,15 mg/kg. disueltos en 4 ml de solución salina durante veinte minutos, también por tres veces y con intervalos similares de tiempo. Se midieron la frecuencia respiratoria y la saturación de oxígeno antes y después del tratamiento, así como la respuesta clínica al mismo y sus efectos secundarios. Los grupos fueron comparables según la edad, la gravedad de la crisis, la evolución previa de la misma y los signos clínicos y paraclínicos iniciales usados en la evaluación. La mejoría de los parámetros fue similar en los dos grupos (p >0,05, lo mismo que el número de respuestas buenas, regulares y malas al tratamiento. Las reacciones secundarias, especialmente la taquicardia, se presentaron en un porcentaje similar de casos: 14 (36,8% en los nebulizados y 7 (21,9% en los inhalados (p=0,27. Se concluye que, en la muestra estudiada, el resultado del tratamiento de la crisis aguda de asma en los niños hasta los seis años, es similar tanto si el salbutamol se administra por inhalación como por nebulización, pues la respuesta clínica y paraclínica y las reacciones secundarias, no son significativamente diferentes. In order to evaluate the effectiveness and safety of inhaled vs nebulized salbutamol, in children between one and six years, a randomized trial was performed in

  20. 77 FR 39406 - Safety Zone; Tom Graves Memorial Fireworks, Port Bay, Wolcott, NY

    Science.gov (United States)

    2012-07-03

    ...-AA00 Safety Zone; Tom Graves Memorial Fireworks, Port Bay, Wolcott, NY AGENCY: Coast Guard, DHS. ACTION..., NY. This safety zone is intended to restrict vessels from a portion of Port Bay during the Tom Graves... necessary to ensure the safety of spectators and vessels during the Tom Graves Memorial Fireworks. This zone...

  1. Grave's Disease and Primary Biliary Cirrhosis—An Unusual and Challenging Association

    OpenAIRE

    Shetty, Shiran; Rajasekaran, Senthilkumar; Venkatakrishnan, Leela

    2013-01-01

    Jaundice in Grave's diseases is uncommon, but when it does occur, complication of thyrotoxicosis (heart failure/infection) or intrinsic liver disease should be considered. Grave's disease can cause asymptomatic elevation of liver enzymes, jaundice and rarely acute liver failure. It is associated with other autoimmune diseases like autoimmune hepatitis, or primary biliary cirrhosis. The cause of jaundice in Grave's disease is multifactorial.

  2. Grave's Disease and Primary Biliary Cirrhosis-An Unusual and Challenging Association.

    Science.gov (United States)

    Shetty, Shiran; Rajasekaran, Senthilkumar; Venkatakrishnan, Leela

    2014-03-01

    Jaundice in Grave's diseases is uncommon, but when it does occur, complication of thyrotoxicosis (heart failure/infection) or intrinsic liver disease should be considered. Grave's disease can cause asymptomatic elevation of liver enzymes, jaundice and rarely acute liver failure. It is associated with other autoimmune diseases like autoimmune hepatitis, or primary biliary cirrhosis. The cause of jaundice in Grave's disease is multifactorial.

  3. Prevalencia de asma y otras enfermedades alérgicas en niños escolares de Ciudad Juárez, Chihuahua

    Directory of Open Access Journals (Sweden)

    Barraza-Villarreal Albino

    2001-01-01

    Full Text Available Objetivo. Determinar la prevalencia y severidad del asma, de la rinitis y del eczema en escolares. Material y métodos. Estudio transversal efectuado entre abril de 1998 y mayo de 1999 en Ciudad Juárez, Chihuahua, México, a una muestra aleatoria de 6 174 niños de 53 escuelas. Se aplicó la metodología propuesta por el International Study of Asthma and Allergies in Childhood (ISAAC (etapas 1 y 2 para determinar la prevalencia y severidad del asma, rinitis y eczema. La información de prevalencia, tanto actual como acumulada para dichos padecimientos, se obtuvo mediante un cuestionario ya estandarizado y contestado por los padres de los niños. El diseño de la muestra se hizo por un muestreo mixto, en el cual se estratificó por nivel de contaminación ambiental. Se estimaron prevalencias actual y acumulada estratificando por grupo de edad, sexo, área e historia familiar de asma. Resultados. La prevalencia acumulada de asma por diagnóstico médico y sibilancia (silbidos fue de 6.8% (IC95% 6.2-7.4 y 20.% (IC95% 19.7-21.8, respectivamente; la prevalencia de sibilancia en los últimos 12 meses fue mayor en el grupo de 6-8 años que en el de 11-14 años(9.7% contra 5.8% (phttp://www.insp.mx/salud/index.html

  4. Contaminación atmosférica, asma bronquial e infecciones respiratorias agudas en menores de edad, de La Habana Air pollution, bronchial asthma, and acute respirator and infections in children less years of age, Habana City

    Directory of Open Access Journals (Sweden)

    Manuel Romero-Placeres

    2004-06-01

    Full Text Available OBJETIVO: Identificar la relación que guardan las consultas de urgencias por enfermedades respiratorias agudas, crisis agudas de asma bronquial e infecciones respiratorias agudas, con los cambios diarios en los niveles de contaminación atmosférica, en menores de 14 años de edad que fueron atendidos en dos centros hospitalarios de la ciudad de La Habana. MATERIAL Y MÉTODOS: Se realizó un estudio ecológico de series de tiempo durante el periodo comprendido entre el 1 de octubre de 1996 y el 11 marzo de 1998. Se estudió la asociación entre la presencia de crisis agudas de asma bronquial, infecciones respiratorias agudas y enfermedades respiratorias agudas por un lado, y la exposición a niveles de partículas menores de 10 µg/m³ (PM10, humo y dióxido de azufre (SO2, por otro; asimismo, se construyeron modelos con la técnica de regresión binomial negativa, para estudiar periodos de latencia de 1 a 5 días y el efecto acumulado de siete días, previos a las consultas de urgencia. RESULTADOS: Los niveles de contaminación atmosférica, por lo general, resultaron bajos, ya que el promedio de 24 horas para PM10, humo y SO2 fue de 59.2 µg/m³ (DE=29.2, 27.7 µg/m³ (DE=21.2 y 21.1 µg/m³ (DE=20.1, respectivamente. Un incremento de 20 µg/m³ en el promedio diario de humo se relacionó con un incremento de 2.2% (IC 95% 0.9-3.6 en el número de consultas de urgencias por crisis agudas de asma bronquial. Un incremento de 20 µg/m³ en el promedio diario de humo y de SO2 se relacionó con un incremento en las infecciones respiratorias agudas de 2.4% (95% CI 1.2-3.6 y 5% (95% CI 1.3-5.3, respectivamente, con un retraso de cinco días. Además, se presentó un efecto acumulado en todos los contaminantes estudiados. CONCLUSIONES: Los resultados sugieren que los niveles de contaminantes atmosféricos en la ciudad de La Habana afectan la salud respiratoria de los niños, por lo que se requiere de la aplicación de medidas de control, en particular

  5. ACTIVIDAD ANTIINFLAMATORIA DEL EXTRACTO ETANÓLICO DE Desmodium molliculum EN EL MODELO MURINO DE ASMA

    Directory of Open Access Journals (Sweden)

    Bertha Acero-Carrión

    2013-08-01

    Full Text Available Objetivos: Se investiga el efecto del extracto etanolico del Desmodium molliculum sobre el infiltrado leucocitario en tejido pulmonar y la medicion de IgE serica especifica de alergeno. Determinar el efecto de Desmodium molliculum en la inflamacion alergica. Metodología: Ratones hembra de la cepa BALB/c fueron inducidos mediante inyeccion intraperitoneal y nebulizacion con ovoalbumina. El extracto liofilizado de Desmodium molliculum fue administrado por canulacion orogastrica durante 7 dias una semana despues de la ultima nebulizacion. Se evaluaron los efectos del extracto sobre la inflamacion leucocitaria en cortes de pulmon tenidos con Hematoxilina-eosina y los valores sericos de IgE. Resultados: Mediante la prueba de Tukey con p=0,05 se obtuvieron valores de diferencia de medias respecto al blanco; para la dosis de 250mg/Kg fue -150,345 (significancia=0,001; para 500mg/Kg, -59,342 (0,019; y para 1000mg/Kg, -89.771 (0,001; la mas efectiva fue 500mg/Kg. Se evaluo con la misma prueba diferencia de medias respecto a Dexametasona (2mg/Kg: para control negativo, -158,125 (p=0,001; blanco, 66,95 (0,004; y 500mg/Kg, 7,607 (0,998. El infiltrado peribronquial fue similar para el control (+ y dosis de 250 y 500 mg/Kg; en el perivascular destaco la dosis de 500 mg/Kg. Conclusión: Segun los valores de IgE e inflitrado peribronquial y perivascular en el pulmon, Desmodium molliculum tiene un efecto en la inflamacion alergica, efecto similar al obtenido con Dexametasona.

  6. Quality control of 131I treatment of graves' disease

    International Nuclear Information System (INIS)

    Liu Zeng; Liu Guoqiang

    2009-01-01

    To make a preliminary quality control (QC) criteria and apply on the various stages of clinic 131 I treatment of Graves' disease in order to decrease the early happening of hypothyroidism and enhance the onetime 131 I cure rate of Graves' disease, the quality control criteria in the stochastic outpatient with 131 I treatment, such as plan of the indication, contraindication, method of treatment, matters needing attention, follow-up observation and curative effect appraisal, patient selection, RAIU, thyroid gland weight measurement and 131 I dose criteria for the various steps of 131 I medication were determined. The 131 I treatment effects of Graves' disease including the once-cure rate, the improving rate, duplicate cure rate and the early happening rate of hypothyroidism were analyzed in patients with applying QC and without QC ccriteria. The results showed that the oncecure rate in patients with applying QC criteria was increased from 76.6% to 90.9% (P≤0.01); the improving rate was decreased from 12.2% to 7.0% (P≤0.01); the duplicate cure rate was increased from 90.1% to 93.0% (P>0.05); the early happening rate of hypothyroidism was decreased from 11.0% to 2.1% (P≤0.01). The 131 I treatment of Graves' disease applying with QC criteria had tremendously improved the oncecure rate and decreased the early happening of hypothyroidism rate. (authors)

  7. Graves' orbitopathy as a rare disease in Europe

    DEFF Research Database (Denmark)

    Perros, Petros; Hegedüs, L; Bartalena, L.

    2017-01-01

    BACKGROUND: Graves' orbitopathy (GO) is an autoimmune condition, which is associated with poor clinical outcomes including impaired quality of life and socio-economic status. Current evidence suggests that the incidence of GO in Europe may be declining, however data on the prevalence of this dise...

  8. The plundering of the ship graves from Oseberg and Gokstad

    DEFF Research Database (Denmark)

    Bill, Jan; Daly, Aoife

    2012-01-01

    Not the least of the unusual revelations that have come from the wonderfully preserved ninth-century Norwegian ship burials at Oseberg and Gokstad, is the fact that both had been later broken into-by interlopers who defaced the ship, damaged the grave goods and pulled out and dispersed the bones...

  9. Classification of the eye changes of Graves' disease

    NARCIS (Netherlands)

    Wiersinga, W. M.; Prummel, M. F.; Mourits, M. P.; Koornneef, L.; Buller, H. R.

    1991-01-01

    Classification of the eye changes of Graves' disease may have clinical use in the description of the present eye state, in the assessment of treatment results, and in the choice of therapy. Requirements for any classification system should include simplicity, clinical nature (i.e., easily carried

  10. Diabetes mellitus: a risk factor in patients with Graves' orbitopathy

    NARCIS (Netherlands)

    Kalmann, R.; Mourits, M. P.

    1999-01-01

    AIMS: To assess the prevalence of dysthyroid optic neuropathy (DON) in patients with diabetes mellitus (DM) and Graves' orbitopathy (GO) and to investigate the complications of surgery for GO in these patients. METHODS: The records of 482 consecutive patients with GO referred in a 5 year period were

  11. Contrast sensitivity function in Graves' ophthalmopathy and dysthyroid optic neuropathy

    NARCIS (Netherlands)

    Suttorp-Schulten, M. S.; Tijssen, R.; Mourits, M. P.; Apkarian, P.

    1993-01-01

    Contrast sensitivity function was measured by a computer automated method on 38 eyes with dysthyroid optic neuropathy and 34 eyes with Graves' ophthalmopathy only. The results were compared with 74 healthy control eyes. Disturbances of contrast sensitivity functions were found in both groups when

  12. 131I therapy of Graves' disease using lithium

    International Nuclear Information System (INIS)

    Sato, Kenshi

    1983-01-01

    Lithium is known to cause goiter and hypothyroidism. In the mechanism of goitrogenesis, there is general agreement that lithium inhibits the release of the thyroid hormones from the thyroid gland without significantly impairing other thyroid functions. The present study was undertaken, therefore, to investigate the usefulness of lithium in the radioiodine treatment of Graves' disease. Nine patients with Graves' disease who were all, except one, previously treated with antithyroid drugs were studied. 600 mg of lithium carbonate were administered daily to investigate the effects on thyroidal 131 I uptake, disappearance rate of 131 I from the prelabeled thyroid and the serum concentrations of thyroid hormones. Lithium showed no significant effect on the thyroidal 131 I uptake when the 24 hour thyroidal 131 I uptakes were determined both before and during lithium treatment in the five cases. On the other hand, lithium clearly prolonged the mean value of effective half-lives of 131 I to approximately 8 days vs. 5.1 days before lithium treatment (p 4 and T 3 levels significantly decreased during lithium treatment, from 21.3 to 12.4μg/dl (n=9, p 131 I for the Graves' disease can be reduced by using lithium, the radiation exposure to the total body is decreased. Moreover, it is possible to perform the 131 I therapy while improving the thyrotoxicosis with lithium. Finally, it is concluded that lithium is a very useful drug to be combined with the 131 I therapy of Graves' disease. (author)

  13. [Guideline for the treatment of Graves' disease with antithyroid drug].

    Science.gov (United States)

    Nakamura, Hirotoshi

    2006-12-01

    We have published "Guideline for the Treatment of Graves' Disease with Antithyroid Drug in Japan 2006" in the middle of May from the Japan Thyroid Association. The background, working process, composition, aim and significance of this guideline are described. The most remarkable feature of this guideline is "evidence based".

  14. Radiotherapy for Graves' orbitopathy : randomised placebo-controlled study

    NARCIS (Netherlands)

    Mourits, MP; van Kempen-Harteveld, ML; Garcia, MBG; Koppeschaar, HPF; Tick, L; Terwee, CB

    2000-01-01

    Background The best treatment (steroids, irradiation, or both) for moderately severe Graves' orbitopathy, a self-limiting disease is not known. We tested the efficacy of external beam irradiation compared with sham-irradiation. Methods In a double-blind randomised clinical trial, 30 patients with

  15. CASE REPORT : GRAVE'S DISEASE PRESENTING AS PARANOID SCHIZOPHRENIA

    Science.gov (United States)

    Singh, S.K.; Hatwal, A.; Agarwal, J.K.; Bajpai, H.S.; Sharma, I.

    1989-01-01

    SUMMARY The case of a 37 year old male is described who initially presented as paranoid schizophrenia unresponsive to anti-psychotic drug treatment and subsequently developed features of Grave's disease. Treatment with carbimazole alone improved his psychiatric symptoms. PMID:21927380

  16. [Rituximab: a new therapeutic alternative in Grave's disease].

    Science.gov (United States)

    Tello-Winniczuk, Nina; Díaz-Jouanen, Efraín

    2011-01-01

    Graves' disease is the most frequent cause of hyperthyroidism, affecting mainly young aged women, with an etiology of autoimmune basis. One of its manifestations, Graves' ophthalmopathy whose pathophysiology is unknown, represents one of the greatest therapeutic challenges in these patients, because they require aggressive treatment with steroids and multiple subsequent reconstructive surgeries in certain cases. It also represents a high burden to the health system. Drugs targeting B cells have been very effective for many autoimmune diseases. Rituximab is a murine humanized monoclonal antibody against CD20 + cells currently being studied in various autoimmune diseases including Graves' disease. The objective of this paper is to expose possible mechanisms by which rituximab could act in both hyperthyroidism and ophthalmopathy of Graves' disease, as well as the experience with its use acquired so far. The employment of rituximab in recently diagnosed patients or with mild ophthalmopathy is questionable with the evidence available today however, we think that it may have a role in refractory cases or those who have a contraindication for steroid use.

  17. Personalised immunomodulating treatments for Graves' disease: fact or fiction?

    Science.gov (United States)

    Struja, Tristan Mirko; Kutz, Alexander; Fischli, Stefan; Meier, Christian; Müller, Beat; Schütz, Philipp

    2017-08-14

    Although Graves' disease has been recognised for more than 100 years, its physiopathological mechanisms are incompletely understood. Treatment strategies today mainly focus on suppression of thyroid hormone production by use of antithyroid drugs or radio-iodine, but neglect the underlying immunological mechanisms. Although Graves' disease is often seen as a prototype for an autoimmune mechanism, it is more likely to be a heterogeneous syndrome showing characteristics of both autoimmunity and immunodeficiency. The interplay of these two mechanisms may well characterise the physiopathology of this disease and its complications. Immunodeficiency may be either genetically determined or secondarily acquired. Various triggering events lead to autoimmunity with stimulation of the thyroid gland resulting in the clinical syndrome of hyperthyroidism. Also, relapse risk differs from patient to patient and can be estimated from clinical parameters incorporated into the Graves' Recurrent Events After Therapy (GREAT) score. Accurate risk stratification may help to distinguish high-risk patients for whom a more definitive treatment approach should be used from others where there is a high probability that the disease will recover with medical treatment alone. Several smaller trials having found positive effects of immunosuppressive drugs on recurrence risk in Graves' disease; therefoore, there is great potential in the use of novel immunomodulating drugs in addition to the currently used antithyroid drugs for the successful treatment of this condition. Further in-depth exploration of susceptibility, triggering factors and immunological mechanisms has the potential to improve treatment of Graves' disease, with more personalised, risk-adapted treatment strategies based on the different physiopathological concepts of this heterogeneous condition.

  18. Follow-up of newborns of mothers with Graves' disease.

    Science.gov (United States)

    Levy-Shraga, Yael; Tamir-Hostovsky, Liran; Boyko, Valentina; Lerner-Geva, Liat; Pinhas-Hamiel, Orit

    2014-06-01

    Overt neonatal Graves' disease is rare, but may be severe, even life threatening, with deleterious effects on neural development. The main objective of this study was to describe the course of thyrotropin (TSH) and free thyroxin (fT4) levels, as well as postnatal weight gain in relation to fT4 levels, in neonates born to women with Graves' disease without overt neonatal thyrotoxicosis. Such information is important to deduce the optimal schedule for evaluation. We conducted a retrospective chart review of neonates born to mothers with Graves' disease between January 2007 and December 2012. The records were reviewed for sex, gestational age, birth weight, maternal treatment during pregnancy, and maternal thyroid stimulating immunoglobulin (TSI) level. For each visit in the clinic, the data included growth parameters, presence of symptoms suspected for hyperthyroidism, blood test results (levels of TSH, fT4, and TSI), and treatment. Ninety-six neonates were included in the study (49 males), with a total of 320 measurements of thyroid function tests (TSH and fT4). Four neonates (4%) had overt neonatal Graves' disease; one of them along with nine others were born preterm. In 77 (92.9%) of the remaining 83 neonates (the subclinical group), fT4 levels were above the 95th percentile on day 5. All had normal fT4 on day 15. A negative association was found between fT4 and weight gain during the first two weeks. In this cohort, most neonates born to mothers with Graves' disease had a subclinical course with abnormal fT4 levels that peaked at day 5. After day 14, all measurements of fT4 returned to the normal range, although measurements of TSH remained suppressed for up to three months. Elevated fT4 was associated with poor weight gain.

  19. SUBTOTAL THYROIDECTOMY IN THE MANAGEMENT OF GRAVE'S DISEASE.

    Science.gov (United States)

    Vincent, P J; Garg, M K; Singh, Y; Bhalla, V P; Datta, S

    2001-07-01

    Treatment options for Grave's disease include radio-iodine ablation, which is the standard treatment in the USA, antithyroid drug therapy, which is popular in Japan, and surgery, which is commonly employed in Europe and India. There are very few reports about the outcome of surgery in Grave's disease in the Indian setting. Surgery for Grave's disease is an attractive option in under developed countries to cut short prolonged drug treatment, costly follow up and avoid the need for radio-isotope facilities for 1311 ablation. Aim of the present study was to assess the result of subtotal thyroidectomy in 32 cases of Grave's Disease referred for surgery by the endocrinologist in a teaching hospital. Patients were prepared for surgery with Lugol's iodine and propranalol. Subtotal thyroidectomy was performed by a standard technique, which included dissection and exposure of recurrent laryngeal nerves and parathyroid glands. Actual estimation of weight of the remnant gland was not part of the study. Duration of follow up ranged from 6 months to 4 years. 13 of 32 cases were males. Age ranged from 20 to 57 years. There was 1 death in the immediate post-operative period. There were no cases of permanent hypoparathyroidism or recurrent laryngeal nerve palsy. 1 patient developed temporary hypoparathyroidism. 1 patient developed recurrence of hyperthyroidism and 3 cases developed hypothyroidism all within 2 years of surgery. The study has demonstrated the safety and effectiveness of surgery for Grave's Disease in comparison to the reported high incidence of hypothyroidism following radio-iodine therapy and high recurrence rate after anti thyroid drug therapy.

  20. Graves' orbitopathy as a rare disease in Europe: a European Group on Graves' Orbitopathy (EUGOGO) position statement

    NARCIS (Netherlands)

    Perros, P.; Hegedüs, L.; Bartalena, L.; Marcocci, C.; Kahaly, G. J.; Baldeschi, L.; Salvi, M.; Lazarus, J. H.; Eckstein, A.; Pitz, S.; Boboridis, K.; Anagnostis, P.; Ayvaz, G.; Boschi, A.; Brix, T. H.; Currò, N.; Konuk, O.; Marinò, M.; Mitchell, A. L.; Stankovic, B.; Törüner, F. B.; von Arx, G.; Zarković, M.; Wiersinga, W. M.

    2017-01-01

    Graves' orbitopathy (GO) is an autoimmune condition, which is associated with poor clinical outcomes including impaired quality of life and socio-economic status. Current evidence suggests that the incidence of GO in Europe may be declining, however data on the prevalence of this disease are sparse.

  1. Ensaio clínico, aberto, controlado sobre a adição de brometo de ipratrópio ao fenoterol no tratamento da crise de asma em adultos Open, controlled clinical assay of the addition of ipratropium bromide to fenoterol in the treatment of acute asthma crisis in adults

    Directory of Open Access Journals (Sweden)

    Solange Diccini

    1999-12-01

    Full Text Available No tratamento da crise de asma, empregam-se doses repetidas de drogas b2-agonistas por via inalatória. O efeito da adição do brometo de ipratrópio (BI ao b2-agonistas é controverso em adultos. OBJETIVO: Avaliar se adição de BI ao fenoterol, em tratamentos inalatórios repetidos, induz a maior broncodilatação, com reversibilidade da crise e alta da emergência em pacientes em crise grave de asma. LOCAL DO ESTUDO: Serviço de Pronto-Atendimento de Pneumologia, Disciplina de Pneumologia da Unifesp-Hospital São Paulo, no período de julho de 1995 a fevereiro de 1997. TIPO DE ESTUDO: Aberto, randomizado, paralelo. Alta da emergência determinada pelo VEF1 e PFE > 60% do previsto. CASUÍSTICA E MÉTODOS: Cento e vinte pacientes em crise de asma foram divididos em dois grupos (N = 60: fenoterol (F e brometo de ipratrópio + fenoterol (BIF com VEF1 e PFE Repeated dosis of inhaled b2-agonists have been used in the treatment of acute asthma. The effect of added ipratropium bromide (IB to b2-agonist is controversial in adults. OBJECTIVE: To evaluate if addition of IB to fenoterol, in repeated doses, induces a greater bronchodilation, a greater reversion of the attack, and discharge from emergency unit in adults with acute severe asthma. SETTING: Pneumology Emergency Department, Unifesp-Hospital São Paulo, in the period from July 1995 to February 1997. TYPE OF STUDY: Open, randomized and parallel study. Discharge from the hospital: FEV1 and PEF > 60% of the predicted value. METHODS: 120 patients with FEV1 and PEF < 50% of the predicted value were divided into two groups (N = 60: fenoterol (F and ipratropium bromide + fenoterol (IBF. Each group received inhalation treatment through a metered-dose inhaler (MDI attached to a holding chamber, administered at 30-minute interval, for a total of three treatments. In the group F four puffs of fenoterol (400 mg were administered, and in the IBF group, 160 mg of BI and 400 mg of fenoterol (four puffs

  2. The Eye/Brain Radioactivity Ratio for Assessment of Graves Ophthalmopathy

    International Nuclear Information System (INIS)

    Lee, B. W.; Sung, S. K.; Suh, K. S.; Park, W.; Choi, D. J.; Kim, J. S.

    1988-01-01

    In Graves' disease, changes in orbital tissue and structure are caused by inflammatory infiltration, which induces increase of capillary permeability and breakdown of blood-tissue barriers. Using the uptake of 99m Tc-DTPA in inflammatory lesion, Eye/Brain radioactivity ratios in brain scintigraphy were evaluated in 15 normal controls and 40 Graves' patients. The results were as follows; 1) Eye/Brain radioactivity ratio was significantly higher in Graves' ophthalmopathy group than in control group (p 99m Tc-DTPA brain scintigraphy may be useful to determine the activity of Graves' ophthalmopathy and whether treatment of Graves' ophthalmopathy is necessary or not.

  3. Infecção na modulaçâo da asma The role of infection in asthma

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    J Pinto Mendes

    2008-10-01

    Full Text Available Faz -se uma revisão da influência das infecções no aparecimento e na clínica da asma brônquica. Dá -se o relevo que merece à intervenção virusal, sobretudo ao rinovírus, pela sua influência nas exacerbações, e ao vírus sincicial respiratório, sobre o qual recai a suspeita de poder ser causa determinante no aparecimento da síndroma asmática. Tentam-se esclarecer os mecanismos da resposta imune à agressão virusal em função das debilidades da resposta do asmático e do atópico, sobretudo no período perinatal, salientando -se, ainda, um efeito de potenciação da agressão virusal sobre a resposta atópica. Aborda -se a hipótese higiénica e a sua falta de consistência científica, pelo menos no papel que pretende atribuir a um não demonstrado antagonismo das respostas linfocitárias Th1 e Th2, apontando -se a importância actual da investigação, não das bactérias mas dos produtos bacterianos, como as endotoxinas, na modulação da asma e da atopia, dando -se relevo aos estudos que, a partir deste modelo, demonstram uma influência do ambiente na secreção génica e, consequentemente, no fenótipo. Invocam -se, nas entrelinhas, vários mecanismos que podem explicar a asma neutrofílica que, para muitos, é um paradoxo perante o consagrado domínio do eosinófilo na inflamação asmática.This paper reviews the impact of infections on the onset and clinical course of bronchial asthma. A just emphasis is given to the role viral infections, particularly rhinovirus infections, play in exacerbations, and that played by respiratory syncytial virus, suspected of triggering the asthmatic syndrome. The mechanisms of the immune response to virus attacks are explained, highlighting the asthmatic and allergic patient’s weakened response, particularly in the perinatal period. Further stressed is a potentiating effect of viral aggression on the allergic response. The hygiene hypothesis and its lack of scientific consistency is

  4. The plastic surgeon and Graves disease.

    Science.gov (United States)

    Chiarelli, A

    2004-01-01

    Thyroid-associated ophthalmopathy is a disease caused by autoimmune processes that also affects the thyroid gland and the lower limbs; at orbital level, it involves the muscle and adipose tissue. When medical treatment fails to achieve appreciable results, surgery aims to decompress the orbital cavity. In recent years, the treatment has been considerably improved by the introduction of transpalpebral lipectomy, which has produced valid results especially in cases when extrinsic muscle hypertrophy is limited; if it is severe, however, lipectomy can be combined with expansion of the orbital cavity, thus enabling the latter to be restricted to one or two walls instead of three. Studying 52 patients who underwent orbital decompression involving lipectomy and/or orbital expansion, affecting a total of 96 orbits, enabled an assessment of the pros and cons of the single techniques in an attempt to identify a rational approach to this pathology. It emerged that lipectomy alone may suffice and obtain valid results in cases of mild-to-moderate proptosis (up to 24 mm) with limited extrinsic muscle hypertrophy, whereas orbital expansion--with or without lipectomy--is likely to be necessary in moderate-to-severe cases (proptosis greater than 24 mm). Additional procedures to correct the elevator and retractor muscles of the eyelids were almost always necessary.

  5. Prevalência de asma em adolescentes na cidade de Fortaleza, CE Prevalence of asthma among adolescents in the city of Fortaleza, Brazil

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    Maria de Fátima Gomes de Luna

    2009-11-01

    Full Text Available OBJETIVO: Avaliar a prevalência de asma em adolescentes (13-14 anos na cidade de Fortaleza, CE. MÉTODOS: Estudo transversal utilizando o questionário do International Study of Asthma and Allergies in Childhood e envolvendo 3.015 adolescentes de escolas públicas e privadas entre 2006 e 2007. RESULTADOS: As prevalências de "sibilos alguma vez na vida", "sibilos nos últimos doze meses" (asma ativa e "asma alguma vez na vida" (asma diagnosticada foram, respectivamente, 44,1%, 22,6% e 11,6%. As prevalências de "sibilos alguma vez na vida" (p = 0,001, "1-3 crises de sibilos nos últimos 12 meses" (p = 0,001; asma ativa (p = 0,002; "sono interrompido por sibilos menos que uma vez por semana" (p OBJECTIVE: To determine the prevalence of asthma among adolescents (13-14 years of age in the city of Fortaleza, Brazil. METHODS: This was a cross-sectional study involving 3,015 adolescents at public and private schools between 2006 and 2007. The participants completed the International Study of Asthma and Allergies in Childhood questionnaire. RESULTS: The prevalences of "wheezing ever", "wheezing within the last 12 months" (active asthma and "asthma ever" (physician-diagnosed asthma were 44.1%, 22.6% and 11.6%, respectively. The prevalences of "wheezing ever" (p = 0.001, "1-3 wheezing attacks within the last 12 months" (p = 0.001, active asthma (p = 0.002, "sleep disturbed due to wheezing less than one night per week" (p < 0.001 and "dry cough at night" (p < 0.001 were higher among girls. Private school students presented higher prevalences of "wheezing ever", active asthma, "1-3 wheezing attacks within the last 12 months", "4-12 wheezing attacks within the last 12 months" and physician-diagnosed asthma (p < 0.001 for all, as well as of "exercise-induced wheezing" (p = 0.032. CONCLUSIONS: The prevalence of asthma and asthma-related symptoms in students aged 13-14 years in the city of Fortaleza, Brazil, was high, predominantly among girls and private

  6. Efeitos da asma no estado nutricional em crianças: Revisão sistemática

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    Daniele Andrade da Cunha

    2010-07-01

    Full Text Available Resumo: Introdução: A asma é uma doença inflamatória crónica de alta prevalência, considerada um problema de saúde pública e constitui-se como uma das causas de baixo peso e atraso do crescimento. Objectivo: O objectivo do presente artigo foi rever na literatura os efeitos da asma no estado nutricional em crianças. Material e métodos: Foi realizada uma revisão sistemática com busca de artigos nas bases PubMed, SciELO e LILACS. Foram excluídos os artigos de revisão, estudos com adultos ou pesquisas que não avaliassem os efeitos da asma em crianças. Foram incluídos artigos originais em humanos. Resultados: Na revisão sistemática da literatura foram encontrados 839 na base MEDLINE (1997-2008, 62 artigos na base MEDLINE (1966-1996, 47 no LILACS e 16 no SciELO - Brasil, totalizando 964 artigos. Destes, foram seleccionados 17 artigos. Conclusão: Conclui-se que a evidência de que a asma interfere no estado nutricional não pode ser comprovada neste estudo. Abstract: Introduction: Asthma is a chronic inflammatory disease of high prevalence, considered a public health problem and is thought to be one cause of low birth weight and growth retardation. Purpose: The purpose of this article was to review in literature the effects of asthma on the nutritional status in children. Material and methods: A systematic review was made by searching for articles in PubMed, SciELO and LILACS databases. Review articles, studies with adults or research that did not evaluate the effects of asthma in children were excluded. Hence original articles in humans were included. Results: In the systematic review we found 901 articles in MEDLINE (1966-1996, 47 in LILACS and SciELO in the 16 - Brazil, totaling 964 articles. Of these, 17 articles were selected. Conclusion: Evidence that asthma interferes in nutritional status can not be proven in this study. Palavras-chaves: Asma, estado nutricional, criança, Key

  7. Efeitos da asma no estado nutricional em crianças: Revisão sistemática

    Directory of Open Access Journals (Sweden)

    Daniele Andrade da Cunha

    2010-07-01

    Full Text Available Resumo: Introdução: A asma é uma doença inflamatória crónica de alta prevalência, considerada um problema de saúde pública e constitui-se como uma das causas de baixo peso e atraso do crescimento. Objectivo: O objectivo do presente artigo foi rever na literatura os efeitos da asma no estado nutricional em crianças. Material e métodos: Foi realizada uma revisão sistemática com busca de artigos nas bases PubMed, SciELO e LILACS. Foram excluídos os artigos de revisão, estudos com adultos ou pesquisas que não avaliassem os efeitos da asma em crianças. Foram incluídos artigos originais em humanos. Resultados: Na revisão sistemática da literatura foram encontrados 839 na base MEDLINE (1997-2008, 62 artigos na base MEDLINE (1966-1996, 47 no LILACS e 16 no SciELO Brasil, totalizando 964 artigos. Destes, foram seleccionados 17 artigos. Conclusão: Conclui-se que a evidência de que a asma interfere no estado nutricional não pode ser comprovada neste estudo.Rev Port Pneumol 2010; XVI (4: 617-626 Abstract: Introduction: Asthma is a chronic inflammatory disease of high prevalence, considered a public health problem and is thought to be one cause of low birth weight and growth retardation. Purpose: The purpose of this article was to review in literature the effects of asthma on the nutritional status in children. Material and methods: A systematic review was made by searching for articles in PubMed, SciELO and LILACS databases. Review articles, studies with adults or research that did not evaluate the effects of asthma in children were excluded. Hence original articles in humans were included. Results: In the systematic review we found 901 articles in MEDLINE (1966-1996, 47 in LILACS and SciELO in the 16 Brazil, totaling 964 articles. Of these, 17 articles were selected. Conclusion: Evidence that asthma interferes in nutritional status can not be proven in this study.Rev Port Pneumol 2010

  8. Enfermedad Graves-Basedow. Fisiopatología y Diagnóstico

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    Hernando Vargas-Uricoechea

    2013-03-01

    Full Text Available Se realizó una revisión narrativa rigurosa de la literatura inglesa y en español sobre diferentes aspectos de la Enfermedad de Graves-Basedow, causa de cerca del 80% de todos los casos de hipertiroidismo. Esta patología –parte de la llamada “enfermedad tiroidea autoinmune”- se produce como consecuencia de la presencia de anticuerpos circulantes que se unen y activan al receptor de tirotropina, desencadenándose generalmente el hipertiroidismo en asociación con un estrés agudo. En este artículo describimos la metodología usada para elaborar un estado del arte del bocio difuso tóxico presente en adultos, en relación con sus antecedentes históricos, fisiopatología y diagnóstico, tanto semiológico como imagenológico, patológico y por laboratorio. Los aspectos –tanto del manejo de hipertiroidismo como el de problemas especiales- son motivo de otra publicación.

  9. The clinical value of serum thyrotrophin receptor antibody level in patients with Graves ophthalmopathy

    International Nuclear Information System (INIS)

    Wang Chaodian; Shi Yuhong; Yan Bing

    2013-01-01

    Objective: To explore the value of serum thyrotrophin receptor antibody (TRAb) on the pathological mechanism of Graves ophthalmopathy. Methods: Two hundred and nineteen newly diagnosed Graves disease patients who were divided into Graves ophthalmopathy group (n=121) and without Graves ophthalmopathy group (n=98) were tested serum concentration with thyroid function, thyroperoxidase antibodies (TPOAb), thyroglobulin antibodies (TgAb) and TRAb. According to the consensus statement of the European Group on Graves ophthalmopathy, clinical activity score (CAS) and severity evaluation were carried out on Graves ophthalmopathy patients. Results: There was no significant difference in serum concentration of free thyroxine (FT 4 ), free triiodothyronine (FT 3 ), TPOAb and TRAb between the Graves ophthalmopathy group and the without Graves ophthalmopathy group. Serum concentration of TRAb was not correlated with the severity and CAS of Graves ophthalmopathy. Conclusions: The CAS and the severity of Graves ophthalmopathy were irrelevant to the serum concentration of TRAb. Therefore, the correlation between TRAb and Graves ophthalmopathy still needs further study. (authors)

  10. Ultrasonographic Features of Papillary Thyroid Carcinoma in Patients with Graves' Disease

    Science.gov (United States)

    Chung, Jin Ook; Cho, Dong Hyeok; Chung, Dong Jin

    2010-01-01

    Background/Aims To characterize ultrasonographic findings in papillary thyroid carcinoma (PTC) combined with Graves' disease. Methods Medical records and ultrasonographic findings of 1,013 patients with Graves' disease and 3,380 patients without Graves' disease were analyzed retrospectively. A diagnosis of PTC was based on a pathologic examination. Results The frequency of hypoechogenicity was lower in patients with PTC and Graves' disease than in patients with PTC alone (p Graves' disease was significantly higher than in those with PTC alone (p Graves' disease was characterized by more ill-defined borders and less frequency of overall calcification, punctate calcification, and heterogeneous echogenicity, although the difference was not statistically significant. Conclusions Our results suggest that patients with Graves' disease more frequently have atypical PTC findings on ultrasonography. PMID:20195406

  11. Clinical significance of determination of serum TRAb levels in patients with relapsing graves' disease

    International Nuclear Information System (INIS)

    Guo Chunlei; Zhou Jiaqiang; Li Wenpeng

    2004-01-01

    Objective: To explore the clinical significance of changes of serum TRAb levels in patients with relapsing Graves' disease. Methods: Serum TRAb (with RRA) and several other thyroid-related hormones (TT 4 , TT 3 , TSH, FT 3 , with CLIA) were determined in the following subjects: 1. 25 cases of relapsing Graves' disease after previous successful treatment; 2. 18 cases of recently diagnosed Graves' disease; 3. 31 cases of successfully treated Graves' disease; 4. 15 cases of simple goiter; 5. 10 cases of nodular goiter; 6. 18 cases of hypothyroidism due to Hashimoto disease. Results: Positive rate of TRAb was 76.00% in patients with relapsing Graves' disease and 77.78% in recently diagnosed Graves' disease cases, both being significantly higher than that in all the other sets of patients studied (P<0.01). Conclusion: Determination of serum TRAb levels was helpful for the diagnosis of relapse in Graves' disease

  12. A hospitalização por asma e a carência de acompanhamento ambulatorial Asthma-related hospitalizations and lack of outpatient follow-up treatment

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    Emanuel Sarinho

    2007-08-01

    Full Text Available OBJETIVO: Verificar se as crianças e os adolescentes internados por crise aguda de asma em duas unidades de saúde da cidade do Recife faziam acompanhamento ambulatorial preventivo para controle da asma. MÉTODOS: Estudo prospectivo de uma série de casos de pacientes internados por asma aos quais foi aplicado um questionário no momento da internação para verificar a freqüência de acompanhamento ambulatorial para tratamento profilático. Foi considerado asmático aquele paciente que apresentou duas ou mais crises de broncoespasmo com boa resposta aos broncodilatadores. RESULTADOS: Do total de 169 pacientes internados por asma, 67% (112/167 - dados referentes a 2 pacientes não foram fornecidos foram atendidos exclusivamente em serviços de urgência no período intercrise. Apesar de haver encaminhamento médico para atendimento ambulatorial em 53,3% (89/167 - dados referentes a 2 pacientes não foram fornecidos dos casos, apenas 16% (27/169 dos pacientes efetivamente freqüentavam um ambulatório específico de asma para tratamento preventivo e somente 13% (22/169 usavam medicação profilática. CONCLUSÃO: A maioria das crianças e dos adolescentes internados por asma não fazia acompanhamento ambulatorial preventivo. Uma série de problemas, tais como a não referência para acompanhamento ambulatorial após a alta hospitalar, a dificuldade de acesso ao ambulatório e a impossibilidade de se obter a medicação profilática gratuitamente, entre outros fatores relacionados ao sistema de saúde, podem ter contribuído para esta baixa taxa de procura por atendimento ambulatorial. Recomenda-se a implementação de uma política de saúde que possibilite o efetivo funcionamento do programa de controle da asma.OBJECTIVE: To determine whether the children and adolescents with acute asthma attacks admitted to two public hospitals in the city of Recife, Brazil underwent outpatient follow-up treatment for the prevention and control of asthma

  13. Factores de riesgo para infección respiratoria aguda baja grave en Bogotá, 2001.

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    María Belén Jaimes

    2003-09-01

    Full Text Available La gravedad de la infección respiratoria aguda (IRA es mayor en países en desarrollo, sobre todo entre grupos social y económicamente pobres. Las neumonías virales son las más comunes, especialmente en niños. Con el fin de medir algunos factores asociados con formas graves de infección respiratoria baja realizamos un estudio de casos y controles prospectivo y de base hospitalaria en Bogotá entre noviembre de 2000 y agosto de 2001. Los casos fueron niños entre 2 meses y 5 años que llenaban los criterios de la OMS para IRA grave o muy grave. Los controles eran niños con IRA en el mismo rango de edad, que consultaban al mismo hospital y que no presentaban tirajes. Se estudiaron 638 niños entre los 2 meses y los 5 años de edad (277 casos y 361 controles. Los factores más importantes fueron: vivienda en préstamo (OR=2,7; IC95%: 1,06-7,07, compartir la cama (OR=1,88; IC95%: 1,0-3,7, más de 9 personas en la misma casa (OR=1,82; IC95%: 1,0-3,51 y fumadores en la vivienda (OR=1,4; IC95%: 1,0-2,05. Se tomaron 114 muestras nasofaríngeas (niños con 3 días de haber iniciado síntomas y se obtuvieron virus en 98 de ellas, y se identificó el virus sincitial respiratorio en 41,8%, virus influenza A en 3,1% y virus influenza B en 1%. El 100% de los aislamientos positivos para influenza A y B fueron enviados al CDC en Atlanta, donde fueron clasificados como influenza A/PANAMA/2007/99-like e influenza B/SICHUAN/379/99-like, respectivamente.

  14. Evaluación posoperatoria de los pacientes con úlcera perforada

    OpenAIRE

    López Rodríguez, Pedro; Pol Herrera, Pablo; Cruz Alonso, Juan Ramón; León González, Olga; Anaya González, Jorge Luis

    2013-01-01

    Introducción: la úlcera péptica gastroduodenal constituye después de la hemorragia la complicación ulcerosa más frecuente y la más grave de todas. Ocurre entre el 2 y 5 % de los pacientes con enfermedad ulcerosa y sus síntomas son provocados por la acción del jugo gástrico derramado en la cavidad abdominal. Objetivo: valorar la evolución de los pacientes operados de urgencia con el diagnóstico de úlcera gastroduodenal perforada. Métodos: se realizó un estudio observacional descriptivo con car...

  15. Instrumentos específicos para avaliar a qualidade de vida em crianças e adolescentes com asma

    Directory of Open Access Journals (Sweden)

    Cristian Roncada

    2013-06-01

    Full Text Available OBJETIVO: Identificar e descrever os instrumentos específicos que avaliam a QVRS de crianças e adolescentes com asma. FONTES DOS DADOS: Realizamos buscas nas bases de dados PubMed, Ovid e LILACS utilizando várias combinações de descritores (MeSH terms, selecionando artigos originais sobre desenvolvimento de questionários específicos de QVRS, publicados em inglês, português ou espanhol, entre 1990 e 2012. SÍNTESE DOS DADOS: Foram identificados 15 instrumentos que preencheram os critérios de inclusão. A maioria dos estudos avaliou confiabilidade mediante consistência interna e/ou reprodutibilidade e/ou sensibilidade às mudanças. A validade foi avaliada mediante a comparação com hígidos (validade discordante ou análise fatorial. CONCLUSÕES: Dos 15 instrumentos, três são os mais utilizados, o PAQLQ, o PedsQL-Asthma e DISABKIDS. Em geral, estes três instrumentos possuem características psicométricas adequadas e são práticos de aplicar, mas apenas o PAQLQ completou a adaptação cultural para o Brasil.

  16. Case report of Graves' disease manifesting with odynophagia and heartburn.

    Science.gov (United States)

    Evsyutina, Yulia; Trukhmanov, Alexander; Ivashkin, Vladimir; Storonova, Olga; Godjello, Elina

    2015-12-28

    Graves' disease is an autoimmune disease, which can manifest with a variety of extrathyroidal clinical syndromes like ophthalmopathy, pretibial myxedema (dermopathy), acropathy, cardiomyopathy, and encephalopathy. Though quite rare, this disease can also manifest with gastrointestinal symptoms such as dysphagia, heartburn, nausea, vomiting and diarrhea. We report a clinical case of Graves' disease manifesting with dysfunction of the esophagus and heartburn in a 61-year-old man. In the muscular layer of the esophagus we found dystrophic changes led to its atony, which was documented by endoscopy and high-resolution manometry. The pathology features of esophageal symptoms were: focal proliferation of the basal cells, vascular distension, and dystrophy of the epithelial cells. Antithyroid treatment led to decrease of all clinical symptoms after 5 d of Thiamazole administration. Complete restoration of peristalsis in the esophagus, according to manometry, was observed in 1 mo after initiation of treatment.

  17. The role of radiation therapy in Graves` ophthalmopathy

    Energy Technology Data Exchange (ETDEWEB)

    Chowdhury, A.D.; Moriaty, M.J. [Saint Luke`s Hospital, Dublin (Ireland)

    1996-11-01

    Graves` ophthalmopathy can occur in 25-30% of patients with hyperthyroidism. This condition can result in serious visual disturbance and disfigurement. The treatment options for symptomatic disease are oral corticosteroids or orbital irradiation. Ten patients with Graves` ophthalmopathy were treated with external beam radiotherapy at Saint Lukes Hospital from March 1991 to February 1994. Eight of these patients had excellent response with minimal morbidity. A dose of 2000 cGy in 10 fractions over 2 weeks is considered to be sufficient to alleviate symptoms in most patients. It is concluded that orbital radiotherapy is effective and well tolerated, and should replace corticosteroid therapy as the initial treatment modality in these patients. A minimum follo-up of 6 months is considered adequate for detecting radiation-induced complications. 7 refs., 1 fig.

  18. Habitat Evaluation Procedures Report; Graves Property - Yakama Nation.

    Energy Technology Data Exchange (ETDEWEB)

    Ashley, Paul; Muse, Anthony

    2008-02-01

    A habitat evaluation procedures (HEP) analysis was conducted on the Graves property (140 acres) in June 2007 to determine the number of habitat units to credit Bonneville Power Administration (BPA) for providing funds to acquire the property as partial mitigation for habitat losses associated with construction of McNary Dam. HEP surveys also documented the general ecological condition of the property. The Graves property was significantly damaged from past/present livestock grazing practices. Baseline HEP surveys generated 284.28 habitat units (HUs) or 2.03 HUs per acre. Of these, 275.50 HUs were associated with the shrubsteppe/grassland cover type while 8.78 HUs were tied to the riparian shrub cover type.

  19. Ecocardiograma e fatores de risco cardiovascular em obesos graves

    OpenAIRE

    Elaine Gonçalves Moreira Rocha, Isaura

    2003-01-01

    Introducão: Alterações em parâmetros hemodinâmicos e na função cardíaca ocorrem na obesidade grave, em associação a outros fatores de risco cardiovascular, como dislipidemia, hipertensão arterial e diabete melito. Material e métodos: Foi descrito o perfil clínico, metabólico, ecocardiográfico e o risco de doença cardiovascular, avaliado através do escore de Framingham, em 32 obesos graves candidatos à gastroplastia, no Hospital das Clínicas da Universidade Federal de Pernambuco, entre jane...

  20. Hyperthyroidism and Graves' disease: Is an ultrasound examination needed?

    Directory of Open Access Journals (Sweden)

    Lakshminarayanan Varadhan

    2016-01-01

    Full Text Available Aim: The aim of our study was to assess the limitation of clinical examination in determining the morphology of thyroid gland in patients with hyperthyroidism and its implications. Methods: A retrospective analysis of consecutive patients with hyperthyroidism seen in a tertiary endocrine clinic were analyzed. Sub-analysis was performed on patients with proven Graves' disease. Results: Of the 133 patients included in this study with hyperthyroidism, 60 (45% patients had significant nodularity on ultrasound (US. However, only 67% of these were identified on clinical examination. In patients with confirmed Graves' disease (n = 73, the discordance between US and clinical examination was very similar (18 of 30 patients, 60%. Conclusion: US should form an essential part of the evaluation of hyperthyroidism as the morphology of thyroid gland could be variable and nodules in these glands would also need to be appropriately investigated. This would also significantly influence decision-making and appropriate immediate and follow-up management plan.

  1. Generalised pruritus as a presentation of Grave's disease.

    Science.gov (United States)

    Tan, Ce; Loh, Ky

    2013-01-01

    Pruritus is a lesser known symptom of hyperthyroidism, particularly in autoimmune thyroid disorders. This is a case report of a 27-year-old woman who presented with generalised pruritus at a primary care clinic. Incidental findings of tachycardia and a goiter led to the investigations of her thyroid status. The thyroid function test revealed elevated serum free T4 and suppressed thyroid stimulating hormone levels. The anti-thyroid antibodies were positive. She was diagnosed with Graves' disease and treated with carbimazole until her symptoms subsided. Graves' disease should be considered as an underlying cause for patients presenting with pruritus. A thorough history and complete physical examination are crucial in making an accurate diagnosis. Underlying causes must be determined before treating the symptoms.

  2. [Orbital decompression in Grave's disease: comparison of techniques].

    Science.gov (United States)

    Sellari-Franceschini, S; Berrettini, S; Forli, F; Bartalena, L; Marcocci, C; Tanda, M L; Nardi, M; Lepri, A; Pinchera, A

    1999-12-01

    Grave's ophthalmopathy is an inflammatory, autoimmune disorder often associated with Grave's disease. The inflammatory infiltration involves the retrobulbar fatty tissue and the extrinsic eye muscles, causing proptosis, extraocular muscle dysfunction and often diplopia. Orbital decompression is an effective treatment in such cases, particularly when resistant to drugs and external radiation therapy. This work compares the results of orbital decompression performed by removing: a) the medial and lateral walls (Mourits technique) in 10 patients (19 orbits) and b) the medial and lower walls (Walsh-Ogura technique) in 17 patients (31 orbits). The results show that removing the floor of the orbit enables better reduction of proptosis but more easily leads to post-operative diplopia. Thus it proves necessary to combine the two techniques, modifying the surgical approach on a case-by-case basis.

  3. Emociones en padres y madres con hijos diagnosticados de EMG que han cometido un acto delictivo violento

    OpenAIRE

    Martínez Fenoll, Carla

    2017-01-01

    Antecedentes: El diagnóstico de enfermedad mental grave (EMG) conlleva en los familiares la aparición de diversas emociones, especialmente negativas, que se relacionan directamente con un deterioro de su calidad de vida. Cuando la EMG se relaciona con un acto delictivo violento aumenta tanto la estigmatización de las personas que la padecen, como los cuidados requeridos por sus familiares, por lo que, en estos últimos, las emociones reportadas pueden ser diferentes y particulares. Objetivos: ...

  4. [Efficacy of treatment with I(131) in paediatric Graves disease].

    Science.gov (United States)

    Enes Romero, P; Martín-Frías, M; de Jesús, M; Caballero Loscos, C; Alonso Blanco, M; Barrio Castellanos, R

    2014-01-01

    Radioiodine is an important therapeutic option in young patients with Grave's disease (GD). In the United States it is a widespread therapy, but in Europe its use in paediatrics is still controversial. To report our experience in radioiodine therapy of paediatric GD patients and analyse its effectiveness and safety. We retrospectively studied our paediatric population (de Pediatría. Published by Elsevier Espana. All rights reserved.

  5. Graves' hyperthyroidism and moderate alcohol consumption: evidence for disease prevention

    DEFF Research Database (Denmark)

    Carle, A.; Bülow Pedersen, I.; Knudsen, N.

    2013-01-01

    BACKGROUND: We recently demonstrated that moderate alcohol consumption is associated with a considerable reduction in the risk of autoimmune hypothyroidism, similar to findings in other autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. We aimed to study a possible....... CONCLUSIONS: Moderate alcohol consumption is associated with a considerable reduction in the risk of Graves' disease with hyperthyroidism - irrespective of age and sex. Autoimmune thyroid disease seems to be much more dependent on environmental factors than hitherto anticipated....

  6. Does radioiodine cause the ophthalmopathy of Graves' disease?

    International Nuclear Information System (INIS)

    McDougall, I.R.

    1993-01-01

    This editorial briefly reviews studies which might answer the question as to whether radioiodine treatment causes the ophthalmopathy of Graves' disease. However, the data do not allow any conclusion one way or the other. Other possible causal factors are discussed. Further studies are required to define whether treatment of hyperthyroidism aggravates the ophthalmopathy and whether one thereby is worse than the others and by how much. (UK)

  7. 233. Explante emergente de una corevalve por leak grave objetivo

    Directory of Open Access Journals (Sweden)

    F. Gomera

    2012-04-01

    Conclusiones: La implantación de TAVI está demostrando ser una buena opción para el tratamiento de la estenosis aórtica grave no susceptible de sustitución quirúrgica. Sin embargo, está terapia aún está lejos de estar libre de complicaciones que requieran cirugía urgente de rescate.

  8. Hyperthyroidism and Graves? disease: Is an ultrasound examination needed?

    OpenAIRE

    Varadhan, Lakshminarayanan; Varughese, George Iype; Sankaranarayanan, Sailesh

    2016-01-01

    Aim: The aim of our study was to assess the limitation of clinical examination in determining the morphology of thyroid gland in patients with hyperthyroidism and its implications. Methods: A retrospective analysis of consecutive patients with hyperthyroidism seen in a tertiary endocrine clinic were analyzed. Sub-analysis was performed on patients with proven Graves' disease. Results: Of the 133 patients included in this study with hyperthyroidism, 60 (45%) patients had significant nodularity...

  9. A Patient with Grave's Disease and Tuberculous Lymphadenitis.

    Science.gov (United States)

    Rahaman, M F; Chowdhury, M H; Khan, A H; Rahman, M; Barman, T K; Chowdhury, M J

    2016-04-01

    Immune reactivity between Mycobacteria and human antigens can play an important role in the pathogenesis of autoimmune disease. We report a case of Graves's disease and tuberculous lymphadenitis to explain the mechanism of correlation between immune-mediated diseases and tuberculosis and to raise awareness of the importance of screening for TB in this context, especially in endemic country. Screening for latent TB at immune mediated disease diagnosis and regular timely screening thereafter may be beneficial.

  10. Graves' disease: A comparison of CT and orthoptic findings

    International Nuclear Information System (INIS)

    Hilbertz, T.; Markl, A.; Pickardt, C.R.; Boergen, K.P.; Muenchen Univ.; Muenchen Univ.

    1988-01-01

    The correlation between the loss of function of the extrinsic rectus eyemuscles and their appearance on computed tomography images in patients with Graves' disease was examined. Pathologic changes of a single rectus eyemuscle normally blockade the movement of the corresponding antagonistic muscle. This is caused by the impossibility to relax due to fibrotic alterations. Nevertheless there are some hints, which indicate, that in some cases, especially concerning the lateral rectus muscle, the inherent function of the thickened muscle is restricted. (orig.) [de

  11. Treatment of Graves' disease and the course of ophthalmopathy

    International Nuclear Information System (INIS)

    Sridama, V.; DeGroot, L.J.

    1989-01-01

    Contradictory results have been obtained with regards to the effect of various treatment modes on the exacerbation of Graves' ophthalmopathy, probably because the number of patients in each study was small and some studies were analyzed only in relation to one type of treatment. To circument these problems, we studied the course of Graves' ophthalmopathy after various modes of therapy for thyrotoxicosis among 537 patients with Graves' disease. A total of 537 patients with Graves' disease were prospectively studied over an 11-year period. Thirty-one patients were lost to follow-up during the first six months after treatment and were excluded from the study. Of those remaining, 426 received one form of treatment, 79 received two kinds of therapy, and one received three kinds of therapy. Thus, surgical treatments numbered 164, radioactive iodine-131 ( 13 1I) treatments numbered 241, and medical treatments numbered 182. Ocular signs were considered improved or exacerbated by the following criteria: decrement or increment of the exophthalmos of 2 mm or more, improvement or deterioration of visual acuity, and regression or progression of extraocular muscle involvement causing diplopia. Among patients who did not have infiltrative ophthalmopathy before treatment, there was no difference in the occurrence of posttreatment exophthalmos in the surgically, medically, and 131I-treated patients (7.1%, 6.7%, and 4.9%, respectively). The incidence and the degree of progression of ophthalmopathy in patients who already had exophthalmos before treatment were similar in the medically, surgically, and 131I-treated groups (19.2%, 19.8%, and 22.7%, respectively). Most of the progression occurred in the posttreatment euthyroid stage. The incidence of improvement of ophthalmopathy was also similar 14.1%, 12.6%, and 12.3% in the medically, surgically, and 131I-treated patients

  12. PREGO (presentation of Graves' orbitopathy) study: changes in referral patterns to European Group On Graves' Orbitopathy (EUGOGO) centres over the period from 2000 to 2012

    NARCIS (Netherlands)

    Perros, Petros; Žarković, Miloš; Azzolini, Claudio; Ayvaz, Göksun; Baldeschi, Lelio; Bartalena, Luigi; Boschi, Antonella; Bournaud, Claire; Brix, Thomas Heiberg; Covelli, Danila; Ćirić, Slavica; Daumerie, Chantal; Eckstein, Anja; Fichter, Nicole; Führer, Dagmar; Hegedüs, Laszlo; Kahaly, George J.; Konuk, Onur; Lareida, Jürg; Lazarus, John; Leo, Marenza; Mathiopoulou, Lemonia; Menconi, Francesca; Morris, Daniel; Okosieme, Onyebuchi; Orgiazzi, Jaques; Pitz, Susanne; Salvi, Mario; Vardanian-Vartin, Cristina; Wiersinga, Wilmar; Bernard, Martine; Clarke, Lucy; Currò, Nicola; Dayan, Colin; Dickinson, Jane; Knežević, Miroslav; Lane, Carol; Marcocci, Claudio; Marinò, Michele; Möller, Lars; Nardi, Marco; Neoh, Christopher; Pearce, Simon; von Arx, George; Törüner, Fosun Baloş

    2015-01-01

    The epidemiology of Graves' orbitopathy (GO) may be changing. The aim of the study was to identify trends in presentation of GO to tertiary centres and initial management over time. Prospective observational study of European Group On Graves' Orbitopathy (EUGOGO) centres. All new referrals with a

  13. Grave pit modifications and wooden structures in the Great Moravian graves and their information potential for cognition of the social structure of the Great Moravian society

    Czech Academy of Sciences Publication Activity Database

    Mazuch, Marian; Hladík, Marek

    2013-01-01

    Roč. 54, č. 2 (2013), s. 45-55 ISSN 1211-7250 R&D Projects: GA ČR GP13-20936P Keywords : Early Middle Ages * Great Moravia * Mikulčice * burial sites * graves * grave pits * burial pits * wooden structures * funeral rite * social structure * GIS * statistics Subject RIV: AC - Archeology, Anthropology, Ethnology

  14. Modelo para abordar integralmente la mortalidad materna y la morbilidad materna grave

    Directory of Open Access Journals (Sweden)

    Ariel Karolinski

    2015-05-01

    Full Text Available La mortalidad materna es un importante problema de salud pública y de derechos humanos y refleja los efectos de los determinantes sociales sobre la salud de las mujeres. El conocimiento de la magnitud y las causas de las muertes maternas ha sido insuficiente para intervenir efectivamente en el alcance de los Objetivos de Desarrollo del Milenio. Por ello, se plantea un modelo para abordar integralmente la mortalidad materna, con siete campos: priorización y definición del problema, caracterización contextual, amplitud metodológica, gestión del conocimiento, innovación, implementación, y un sistema de monitoreo y evaluación. Este modelo permite abordar los problemas asociados con la mortalidad materna y la morbilidad materna grave mediante la integración, desde una perspectiva anticipatoria, de las complicaciones potencialmente fatales asociadas con el proceso reproductivo y su vigilancia. Se destaca la importancia de la gestión del conocimiento para la reorientación de políticas, programas y la atención sanitaria. Se debe mejorar la interacción y explotar las sinergias entre las personas, las comunidades y los actores del sistema de salud para potenciar los resultados de los programas sanitarios. Se requiere más información científica validada sobre la forma en que las intervenciones deben aplicarse en diferentes entornos. Para ello, es esencial fortalecer la articulación entre los centros de investigación, las agencias de cooperación y los organismos del Estado y su incorporación a las acciones programáticas y a la definición de una nueva agenda de salud de la mujer para la Región de las Américas.

  15. Predictive factors for intraoperative excessive bleeding in Graves' disease.

    Science.gov (United States)

    Yamanouchi, Kosho; Minami, Shigeki; Hayashida, Naomi; Sakimura, Chika; Kuroki, Tamotsu; Eguchi, Susumu

    2015-01-01

    In Graves' disease, because a thyroid tends to have extreme vascularity, the amount of intraoperative blood loss (AIOBL) becomes significant in some cases. We sought to elucidate the predictive factors of the AIOBL. A total of 197 patients underwent thyroidectomy for Graves' disease between 2002 and 2012. We evaluated clinical factors that would be potentially related to AIOBL retrospectively. The median period between disease onset and surgery was 16 months (range: 1-480 months). Conventional surgery was performed in 125 patients, whereas video-assisted surgery was performed in 72 patients. Subtotal and near-total/total thyroidectomies were performed in 137 patients and 60 patients, respectively. The median weight of the thyroid was 45 g (range: 7.3-480.0 g). Univariate analysis revealed that the strongest correlation of AIOBL was noted with the weight of thyroid (p Graves' disease, and preparation for blood transfusion should be considered in cases where thyroids weigh more than 200 g. Copyright © 2014. Published by Elsevier Taiwan.

  16. Piezosurgery in Modified Pterional Orbital Decompression Surgery in Graves Disease.

    Science.gov (United States)

    Grauvogel, Juergen; Scheiwe, Christian; Masalha, Waseem; Jarc, Nadja; Grauvogel, Tanja; Beringer, Andreas

    2017-10-01

    Piezosurgery uses microvibrations to selectively cut bone, preserving the adjacent soft tissue. The present study evaluated the use of piezosurgery for bone removal in orbital decompression surgery in Graves disease via a modified pterional approach. A piezosurgical device (Piezosurgery medical) was used in 14 patients (20 orbits) with Graves disease who underwent orbital decompression surgery in additional to drills and rongeurs for bone removal of the lateral orbital wall and orbital roof. The practicability, benefits, and drawbacks of this technique in orbital decompression surgery were recorded. Piezosurgery was evaluated with respect to safety, preciseness of bone cutting, and preservation of the adjacent dura and periorbita. Preoperative and postoperative clinical outcome data were assessed. The orbital decompression surgery was successful in all 20 orbits, with good clinical outcomes and no postoperative complications. Piezosurgery proved to be a safe tool, allowing selective bone cutting with no damage to the surrounding soft tissue structures. However, there were disadvantages concerning the intraoperative handling in the narrow space and the efficiency of bone removal was limited in the orbital decompression surgery compared with drills. Piezosurgery proved to be a useful tool in bone removal for orbital decompression in Graves disease. It is safe and easy to perform, without any danger of damage to adjacent tissue because of its selective bone-cutting properties. Nonetheless, further development of the device is necessary to overcome the disadvantages in intraoperative handling and the reduced bone removal rate. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Efeito da hipertermia na pancreatite aguda grave experimental

    Directory of Open Access Journals (Sweden)

    Maurício Gustavo Ieri Yamanari

    Full Text Available OBJETIVO: O objetivo deste estudo é avaliar os efeitos da hipertermia na pancreatite aguda (PA grave experimental induzida por ácido taurocólico. MÉTODO: A PA grave foi induzida pela injeção retrógrada de ácido taurocólico a 2,5% ou 5% no ducto pancreático principal. Após a indução, os animais foram colocados numa gaiola contendo duas lâmpadas de 100 W. A temperatura corporal foi aumentada para 39,5ºC e mantida neste nível por 45 minutos. Foram estudados taxa de mortalidade em 72 horas, permeabilidade vascular no pâncreas, porcentagem de água no tecido pancreático, amilase sérica, histologia (edema, necrose acinar e infiltrado inflamatório e níveis séricos de IL-6 e IL-10. RESULTADOS: Não houve alteração em nenhum dos parâmetros avaliados. CONCLUSÃO: Não há benefício da hipertermia na PA grave experimental induzida por ácido taurocólico.

  18. Treatment of Grave's hyperthyroidism-prognostic factors for outcome

    International Nuclear Information System (INIS)

    Alfadda, A.; Malabu, Usman H.; El-Desouki, Mahmoud I.; Al-Rubeaan, Khalid A.; Al-Ruhaily, Atallah D.; Fouda, Mona A.; Al-Maatouq, Mohamed A.; Sulimani, Riad A.

    2007-01-01

    To determine clinical and biochemical features of Grave's disease at presentation predict response to medical and radioiodine treatment. We carried out a retrospective 10-year study of 194 consecutive Saudi subjects with Grave's disease who was treated with antithyroid drugs, radioiodine therapy, or both, between January 1995 and December 2004 at King Khalid University Hospital, Riyadh, Saudi Arabia. At diagnosis, the mean age was 32+-0.9 years. Only 26% of patients had successful outcome after a course of antithyroid medication. None of the clinical or biochemical factors were associated with a favorable outcome of antithyroid treatment. One dose of radioiodine [13-15 mCi (481-555 MBq)] cured hyperthyroidism in 83% of patients. Presence of ophthamopathy at presentation was shown to be a significant contributing factor to failure to respond to a single dose of radioiodine (odds ratio, 6.4; 95%CI, 1.51-24.4; p<0.01). Failure of radioiodine treatment was also associated with higher serum free T3 concentration at presentation (p=0.003). In patients with Grave's hyperthyroidism, radioiodine treatment is associated with higher success rate than antithyroid drugs. A dose of 13-15 mCi (481-555 MBq) seems to practical and effective, and should be considered as first line therapy. Patients with high free T3 concentration and, those with ophthalmopathy at presentation were more likely to fail radioiodine treatment. A higher dose of radioiodine may be advisable in such patients. (author)

  19. Graves' disease and toxic nodular goiter - radioiodine therapy

    International Nuclear Information System (INIS)

    Schicha, H.; Dietlein, M.

    2002-01-01

    At the 15th conference on the human thyroid in Heidelberg in 2001 the following aspects of the radioiodine therapy of benign thyroid disorders were presented: General strategies for therapy of benign thyroid diseases, criterions for conservative or definitive treatment of hyperthyroidism as first line therapy and finally preparation, procedural details, results, side effects, costs and follow-up care of radioiodine therapy as well as legal guidelines for hospitalization in Germany. The diagnosis Graves' hyperthyroidism needs the decision, if rather a conservative treatment or if primary radioiodine therapy is the best therapeutic approach. In the USA 70-90% of these patients are treated with radioiodine as first line therapy, whereas in Germany the conservative therapy for 1-1.5 years is recommended for 90%. This review describes subgroups of patients with Graves' disease showing a higher probability to relapse after conservative treatment. Comparing benefits, adverse effects, costs, and conveniences of both treatment strategies the authors conclude that radioiodine therapy should be preferred as first line therapy in 60-70% of the patients with Graves' hyperthyroidism. (orig.) [de

  20. Hyperparathyroidism after radioactive iodine therapy for Graves' disease

    International Nuclear Information System (INIS)

    Kawamura, Juichi; Tobisu, Kenichi; Sanada, Shingo

    1983-01-01

    Herein we report a 36-year-old man with hyperparathyroidism and a past history of internal irradiation to the thyroid. Twelve years previously at age 24 years he had received 8 mCi of radioactive iodine for Graves' disease. An additional dose of 4 mCi was required 3 years later. A right lower parathyroid adenoma (28 x 23 x 20 mm, 5.7 g) was found at neck exploration. Although the association of external ionizing radiation to the head and neck and the subsequent development of hyperfunctioning parathyroid glands has been described in recent years, there are only 4 cases in the literature of parathyroid surgery for hyperparathyroidism secondary to earlier treatment with radioactive iodine for Graves' disease. In a long-term follow-up of 180 patients treated with radioactive iodine for Graves' disease, neither hypercalcemia nor hypophosphatemia was found. Whether internal radiation therapy can be a causative factor in the development of hyperparathyroidism should be elucidated in future. However, it seems reasonable to suggest that patients whose hyper-thyroidism has been treated with radioactive iodine should have their scrum calcium levels examined at 5-year intervals. (author)

  1. Enhanced thyroid iodine metabolism in patients with triiodothyronine-predominant Graves' disease

    International Nuclear Information System (INIS)

    Takamatsu, J.; Hosoya, T.; Naito, N.

    1988-01-01

    Some patients with hyperthyroid Graves' disease have increased serum T3 and normal or even low serum T4 levels during treatment with antithyroid drugs. These patients with elevated serum T3 to T4 ratios rarely have a remission of their hyperthyroidism. The aim of this study was to investigate thyroid iodine metabolism in such patients, whom we termed T3-predominant Graves' disease. Mean thyroid radioactive iodine uptake was 51.0 +/- 18.1% ( +/- SD) at 3 h, and it decreased to 38.9 +/- 20.1% at 24 h in 31 patients with T3-predominant Graves' disease during treatment. It was 20.0 +/- 11.4% at 3 h and increased to 31.9 +/- 16.0% at 24 h in 17 other patients with hyperthyroid Graves' disease who had normal serum T3 and T4 levels and a normal serum T3 to T4 ratio during treatment (control Graves' disease). The activity of serum TSH receptor antibodies was significantly higher in the patients with T3-predominant Graves' disease than in control Graves' disease patients. From in vitro studies of thyroid tissue obtained at surgery, both thyroglobulin content and iodine content in thyroglobulin were significantly lower in patients with T3-predominant Graves' disease than in the control Graves' disease patients. Thyroid peroxidase (TPO) activity determined by a guaiacol assay was 0.411 +/- 0.212 g.u./mg protein in the T3-predominant Graves' disease patients, significantly higher than that in the control Graves' disease patients. Serum TPO autoantibody levels determined by immunoprecipitation also were greater in T3-predominant Graves' disease patients than in control Graves' disease patients. Binding of this antibody to TPO slightly inhibited the enzyme activity of TPO, but this effect of the antibody was similar in the two groups of patients

  2. TSHR intronic polymorphisms (rs179247 and rs12885526) and their role in the susceptibility of the Brazilian population to Graves' disease and Graves' ophthalmopathy.

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    Bufalo, N E; Dos Santos, R B; Marcello, M A; Piai, R P; Secolin, R; Romaldini, J H; Ward, L S

    2015-05-01

    Intronic thyroid-stimulating hormone receptor polymorphisms have been associated with the risk for both Graves' disease and Graves' ophthalmopathy, but results have been inconsistent among different populations. We aimed to investigate the influence of thyroid-stimulating hormone receptor intronic polymorphisms in a large well-characterized population of GD patients. We studied 279 Graves' disease patients (231 females and 48 males, 39.80 ± 11.69 years old), including 144 with Graves' ophthalmopathy, matched to 296 healthy control individuals. Thyroid-stimulating hormone receptor genotypes of rs179247 and rs12885526 were determined by Real Time PCR TaqMan(®) SNP Genotyping. A multivariate analysis showed that the inheritance of the thyroid-stimulating hormone receptor AA genotype for rs179247 increased the risk for Graves' disease (OR = 2.821; 95 % CI 1.595-4.990; p = 0.0004), whereas the thyroid-stimulating hormone receptor GG genotype for rs12885526 increased the risk for Graves' ophthalmopathy (OR = 2.940; 95 % CI 1.320-6.548; p = 0.0083). Individuals with Graves' ophthalmopathy also presented lower mean thyrotropin receptor antibodies levels (96.3 ± 143.9 U/L) than individuals without Graves' ophthalmopathy (98.3 ± 201.9 U/L). We did not find any association between the investigated polymorphisms and patients clinical features or outcome. We demonstrate that thyroid-stimulating hormone receptor intronic polymorphisms are associated with the susceptibility to Graves' disease and Graves' ophthalmopathy in the Brazilian population, but do not appear to influence the disease course.

  3. Simultaneous induction of Graves' hyperthyroidism and Graves' ophthalmopathy by TSHR genetic immunization in BALB/c mice.

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    Nan Xia

    Full Text Available Graves' disease is the most common form of autoimmune thyroid disorder, characterized by hyperthyroidism due to circulating autoantibodies. To address the pathological features and establish a therapeutic approach of this disease, an animal model carrying the phenotype of Graves' disease (GD in concert with Graves' Ophthalmopathy (GO will be very important. However, there are no ideal animal models that are currently available. The aim of the present study is to establish an animal model of GD and GO disease, and its pathological features were further characterized.A recombinant plasmid pcDNA3.1- T289 was constructed by inserting the TSHR A-subunit gene into the expression vector pcDNA3.1, and genetic immunization was successfully performed by intramuscular injection of the plasmid pcDNA3.1-T289 on female 8-week-old BALB/c mice. Each injection was immediately followed by in vivo electroporation using ECM830 square wave electroporator. Morphological changes of the eyes were examined using 7.0T MRI scanner. Levels of serum T4 and TSHR antibodies (TRAb were assessed by ELISA. The pathological changes of the thyroid and orbital tissues were examined by histological staining such as H&E staining and Alcian blue staining.More than 90% of the immunized mice spontaneously developed goiter, and about 80% of the immunized mice manifested increased serum T4 and TRAb levels, combined with hypertrophy and hyperplasia of thyroid follicles. A significantly increased synthesis of hyaluronic acid was detected in in the immunized mice compared with the control groups.We have successfully established an animal model manifesting Graves' hyperthyroidism and ophthalmopathy, which provides a useful tool for future study of the pathological features and the development of novel therapies of the diseases.

  4. A USE-WEAR ANALYSIS OF THE KNAPPED LITHIC GRAVE GOODS FROM GRUTA DO MORGADO SUPERIOR (TOMAR, PORTUGAL

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    Ana Cruz

    2015-12-01

    Full Text Available The Morgado Superior cave is a karst cave located in the municipality of Tomar (Santarém, Portugal. As other caves of the same area, it has provided stratigraphic data and votive deposits falling within the Holocene, more precisely in a diachronic time range that extends from the Neolithic to the early Bronze Age. In the Morgado Superior cave there are multiple burials with a few votive objects like jars, bone artefacts and lithic tools (blades, arrowheads etc., beads, pendants, and other decorative items in association with more than 8,000 human bones: the number of the grave goods elements is low if compared with the number of individuals buried in the cave. Concerning the use-wear study, we analyzed the grave goods in order to understand both their meaning in this funerary context and their function in the economy of this prehistoric society. We focused on the most representative elements of the grave goods: arrowheads and knapped lithic artefacts. This study led us to understand that the majority of the grave goods were everyday objects but with a strong symbolic value. Since in the Morgado Superior Cave there are a lot of grave goods showing prior breaks, their symbolic value does not seem to be lost even if the objects were broken. Thus, the use-wear analysis of the grave goods from the Morgado Superior Cave allowed us to identify the strong symbolic value of these elements for that human community, but at the same time to hypothesize a funerary practice that did not provide a special respect for the body and the grave goods of those dead previously buried in the cave. For these reasons we hypothesize a progressive spoliation (probably ritual of the previous grave goods. Through the use-wear study of the knapped lithic assemblage of the Morgado Superior Cave it was possible to reconstruct part of the ritual activities that were carried out in the site: the 90% of the lithic artefacts are used objects, all of the artefacts have been

  5. Grave's Disease and Primary Biliary Cirrhosis—An Unusual and Challenging Association

    Science.gov (United States)

    Shetty, Shiran; Rajasekaran, Senthilkumar; Venkatakrishnan, Leela

    2013-01-01

    Jaundice in Grave's diseases is uncommon, but when it does occur, complication of thyrotoxicosis (heart failure/infection) or intrinsic liver disease should be considered. Grave's disease can cause asymptomatic elevation of liver enzymes, jaundice and rarely acute liver failure. It is associated with other autoimmune diseases like autoimmune hepatitis, or primary biliary cirrhosis. The cause of jaundice in Grave's disease is multifactorial. PMID:25755537

  6. Manejo da asma aguda em adultos na sala de emergência: evidências atuais Management of acute asthma in adults in the emergency room: current evidence

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    Paulo de Tarso Roth Dalcin

    2009-01-01

    Full Text Available Asma é uma doença com uma alta prevalência em nosso meio e ao redor do mundo. Embora novas opções terapêuticas tenham sido recentemente desenvolvidas, parece haver um aumento mundial na sua morbidade e mortalidade. Em muitas instituições, as exacerbações asmáticas ainda se constituem em uma emergência médica muito comum. As evidências têm demonstrado que o manejo da asma aguda na sala de emergência concentra decisões cruciais que podem determinar o desfecho desta situação clínica. Nesta revisão, enfocaremos a avaliação e o tratamento do paciente com asma aguda na sala de emergência, descrevendo uma estratégia apropriada para o seu manejo. Serão consideradas as seguintes etapas: diagnóstico, avaliação da gravidade, tratamento, avaliação das complicações, decisão sobre onde se realizará o tratamento adicional e orientações por ocasião da alta da emergência. Espera-se que estas recomendações contribuam para que o médico clínico tome as decisões apropriadas durante o manejo da asma aguda na sala de emergência.Asthma is a disease with high prevalence in our country and worldwide. Although new therapeutic approaches have been developed recently, there seems to be a global increase in morbidity and mortality from asthma. In many institutions, asthma exacerbation is still a common medical emergency. Clinical evidence demonstrates that management of acute asthma in the emergency room entails crucial decisions that could determine the clinical outcome. In this review, the authors focus on assessment and treatment of patients with acute asthma and outline an appropriate management strategy. Diagnosis, severity assessment, treatment, complications, decision about where additional treatment will take place and orientations on discharge from the emergency will be considered. It is expected that these recommendations will help physicians to make the appropriate decisions about care of acute asthma in the emergency

  7. Aplicación de un programa de entrenamiento para el automanejo del asma bronquial