MoP nanoparticles supported on indium-doped porous carbon. Outstanding catalysts for highly efficient CO{sub 2} electroreduction

Energy Technology Data Exchange (ETDEWEB)

Sun, Xiaofu; Lu, Lu; Yang, Dexin; Chen, Chunjun; Han, Buxing [Beijing National Laboratory for Molecular Sciences, Key Laboratory of Colloid and Interface and Thermodynamics, Institute of Chemistry Chinese Academy of Sciences, Beijing (China); University of Chinese Academy of Sciences, Beijing (China); Zhu, Qinggong; Wu, Congyi [Beijing National Laboratory for Molecular Sciences, Key Laboratory of Colloid and Interface and Thermodynamics, Institute of Chemistry Chinese Academy of Sciences, Beijing (China)

2018-02-23

Electrochemical reduction of CO{sub 2} into value-added product is an interesting area. MoP nanoparticles supported on porous carbon were synthesized using metal-organic frameworks as the carbon precursor, and initial work on CO{sub 2} electroreduction using the MoP-based catalyst were carried out. It was discovered that MoP nanoparticles supported on In-doped porous carbon had outstanding performance for CO{sub 2} reduction to formic acid. The Faradaic efficiency and current density could reach 96.5 % and 43.8 mA cm{sup -2}, respectively, when using ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate as the supporting electrolyte. The current density is higher than those reported up to date with very high Faradaic efficiency. The MoP nanoparticles and the doped In{sub 2}O{sub 3} cooperated very well in catalyzing the CO{sub 2} electroreduction. (copyright 2018 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim)

Dose-dependent elimination of 8-methoxypsoralen in the mouse

International Nuclear Information System (INIS)

Cheney, P.; Pacula, C.M.; Gerber, N.; Mays, D.C.

1986-01-01

8-Methoxypsoralen (8-MOP), a photoactive linear furocoumarin, is effective in the treatment of several diseases, including psoriasis, mycosis fungoides and T-cell leukemia. Recently, a specific extraction procedure for 14 C-8-MOP showed that the elimination of 8-MOP in the rat was dose-dependent. Similar pharmacokinetic studies were undertaken in mice. Purity of 14 C-8-MOP, verified by a four-tube countercurrent distribution using hexane (8 ml) and pH 7.4 phosphate buffer (0.1 M 15 ml) as described by Bush, was >98% and distributed with a partition coefficient of 3.86. Male CD-1 mice were each given an i.p. dose of 10 or 50 mg/kg of 14 C-8-MOP (3.4 μCi/mg) sacrificed at timed intervals, homogenized in 150 ml of 0.1 M phosphate buffer (pH 7.4) and a portion (0.8 ml) of the homogenate used to quantify 8-MOP as described above. The elimination half-life measured in the first 45 min was 7.4 min at 10 mg/kg and 95 min at 50 mg/kg. A similar half-life of 9.2 min was measured in mice given an i.v. dose 10 mg/kg of 8-MOP. Explanations of dose-dependent elimination include enzyme saturation, product inhibition or both. Between 58-80% of the administered radioactivity was recovered in the urine within 24 hr. Nine peaks of radioactivity were observed in the urine by HPLC, two of which coeluted with 5,8-dihydroxypsoralen and 6-(7-hydroxy-8-methoxycoumaryl)-acetic acid

Detección y cuantificación del Potato mop-top virus (PMTV) en Colombia mediante qRT-PCR

OpenAIRE

Nevar García Bastidas; Pablo Gutiérrez Sánchez; Mauricio Marín Montoya

2013-01-01

El Potato mop-top virus (PMTV) es uno de los virus re-emergentes en cultivos de papa en Colombia. Es transmitido por Spongospora subterranea, el agente causal de la sarna polvosa. La detección del PMTV presenta dificultades debido a su distribución irregular en las plantas, bajo título y movimiento sistémico como ARN desnudo. Con el fin de ampliar el rango de herramientas disponibles para detectar el PMTV en los programas de certificación de tubérculo-semilla, en este estudio se evaluó la pru...

In situ groundwater MOP-UP. Topical report, April 12, 1996--May 11, 1998

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-09-01

Under this FETC-funded program, Biopraxis proposed to demonstrate the feasibility of using its new MOP-UP technology for in situ treatment of metal-contaminated groundwater. Instead of optimizing the technology to demonstrate the feasibility of its use at a single site, the final series of tests were designed to showcase the breadth and flexibility of the MOP-UP technology by demonstrating its capabilities in as many different groundwater environments as possible. Sites that were contaminated with metal pollutants of wide-spread concern to DOE were located; and MOP-UP reagents were screened for their ability to treat any or all of these metals--without any attempt to optimize the technology for use with the new target metals and/or for treating these metals under the diverse conditions found at the sites. Groundwater samples exhibiting a wide range of environments were generously provided by DoD, EPA, and private industry as well as DOE for use in these treatability tests. The tests showed that MOP-UP can readily remove all detectable traces of a wide variety of metals, such as Hg, Pb, Cd, Cu, Cr(VI), As, Ba, Zn, and Al, and take U into the low parts per trillions, in heavily polluted groundwater, with little or no effort needed to optimize the reagent formulation. The second goal of the program was to show that the in situ groundwater MOP-UP technology will either be more cost effective than conventional technologies while achieving the same degree of groundwater purification, or be at least as cost effective as conventional technologies while offering superior performance. MOP-UP far surpassed the goals established for this initial feasibility demonstration. This new technology promises to be extremely effective and very economical whether used in a permeable barrier for treating shallow plumes, or a direct injection or pump-and-treat configuration for treating deep-subsurface plumes of heavy metal, radionuclide, or mixed contamination.

The immunological effect of 8-methoxypsoralen and UVA treatment on murine T-cell leukemia

International Nuclear Information System (INIS)

Tingying Cheng; Fungwin Shen; Ronghwa Lin

1996-01-01

8-Methoxyproralen (8-MOP) plus long-wavelength UV radiation (UVA, 320-400 nm) have been used to treat various diseases such as cutaneous T-cell lymphoma, systemic scleroderma, rheumatoid arthritis and rejection of heart transplants. However, the immunological mechanism of this treatment remains unknown. In this report, we investigated the effect of 8-MOP/UVA on the modulation of the immunogenicity of a T-cell leukemia cell line (RL ''male'' 1 cells). The results demonstrated that the stimulator function of the in vitro 8-MOP/UVA-treated RL ''male'' 1 cells was enhanced in both RL ''male'' 1-specific allogeneic and syngeneic immune responses. Furthermore, the enhancement of the immunogenicity of the 8-MOP/UVA-treated RL ''male'' 1 cells was found to be strongly associated with the increase of intercellular adhesion molecule-1 expression on these 8-MOP/UVA-treated tumor cells. Therefore, our findings suggested that the alteration of the expression of the immune-related cell surface molecules might be an important effect of 8-MOP/UVA treatment on the elevation of the immunogenicity of the 8-MOP/UVA-treated tumor cells. (Author)

The immunological effect of 8-methoxypsoralen and UVA treatment on murine T-cell leukemia

Energy Technology Data Exchange (ETDEWEB)

Tingying Cheng; Fungwin Shen; Ronghwa Lin [National Taiwan Univ., Taipei (China)

1996-09-01

8-Methoxyproralen (8-MOP) plus long-wavelength UV radiation (UVA, 320-400 nm) have been used to treat various diseases such as cutaneous T-cell lymphoma, systemic scleroderma, rheumatoid arthritis and rejection of heart transplants. However, the immunological mechanism of this treatment remains unknown. In this report, we investigated the effect of 8-MOP/UVA on the modulation of the immunogenicity of a T-cell leukemia cell line (RL ``male`` 1 cells). The results demonstrated that the stimulator function of the in vitro 8-MOP/UVA-treated RL ``male`` 1 cells was enhanced in both RL ``male`` 1-specific allogeneic and syngeneic immune responses. Furthermore, the enhancement of the immunogenicity of the 8-MOP/UVA-treated RL ``male`` 1 cells was found to be strongly associated with the increase of intercellular adhesion molecule-1 expression on these 8-MOP/UVA-treated tumor cells. Therefore, our findings suggested that the alteration of the expression of the immune-related cell surface molecules might be an important effect of 8-MOP/UVA treatment on the elevation of the immunogenicity of the 8-MOP/UVA-treated tumor cells. (Author).

Mutagenicity of 8-methoxypsoralen and long-wave ultraviolet irradiation in V-79 Chinese hamster cells

International Nuclear Information System (INIS)

Burger, P.M.; Simons, J.W.I.M.

1979-01-01

The effect of 8-methoxypsoralen (8-MOP) and long-wave ultraviolet irradiation (UVA) on cell killing and mutation induction was studied in V-79 Chinese hamster cells. No effect was observed after treatment with 8-MOP alone (50 μg/ml, 4 h), UVA alone (9000 J/m 2 ), or 8-MOP metobolized by rat-liver microsomes. Combined treatment with 8-MOP and UVA induced both cell killing and mutation. This was also observed under conditins approaching patient treatment with PUVA photochemotherapy with respect to the concentration of 8-MOP in the skin and the amount of UVA received by the epidermal cells. A simple relation proved to apply for mutation induction under different treatment conditions: 5.5 X 10 -8 per J/m 2 per μg 8-MOP/ml. On this basis the mutation induction in dividing cells per session of PUVA-photochemotherapy amounts to 12.4 X 10 -5 , which is probably an over-estimation. (Auth.)

Low level chemiluminescence measurement of the binding of 8-methoxypsoralen to proteins and lymphocytic surfaces

International Nuclear Information System (INIS)

Lange, B.

1980-01-01

Photochemotherapy with 8-methoxypsoralen (8-MOP) and longwave ultraviolet light is beneficial in such different disorders like psoriasis, lichen planus, and mykosis fungoides. In contrast to a widely accepted hypothesis 8-MOP does not solely bind to nucleic acid, but also to certain proteins. The mechanism of this binding as well as the precise binding area are unknown. Therefore the UV-provoked reactions of 8-MOP with a lipid mixture, a glucosaminoglycan solution, a protein solution, and lymphocyte suspensions, respectively were investigated using low level chemiluminescence (LLCL). It was found an 8-MOP concentration-dependent decrease of LLCL intensity in the lymphocyte suspensions (10 3 to 10 4 cells/μl). This effect is result of the diminution of the photoactive 8-MOP content of the solution. 8-MOP binds quickly and in the course of a free radical reaction to lymphocytic surfaces and coincidentally loses its potency to start LLCL-detectable free radical chain responses. (author)

Comparison of the mopping ability of chemically modified and unmodified biological wastes on crude oil and its lower fractions.

Science.gov (United States)

Nduka, John Kanayochukwu; Ezenweke, Linus Obi; Ezenwa, Emmanuel Tagbo

2008-11-01

Activated and unactivated powders of goat hair and coir (coconut husk) separated into two particle sizes were used to mop up spills of crude oil, diesel, kerosene and petrol. It was observed that the materials (sorbents) mopped up appreciable volumes of the hydrocarbon liquids (sorbates) within 90 min of contact. Activation, particle size of sorbents and molecular weight (chain length) of sorbates (hydrocarbon) are major determining factors. Carbonization and particle size enhanced the mopping ability as follows--carbonized 325 microm > uncarbonized 325 microm > carbonized 625 microm > uncarbonized 625 microm, thus activated sorbents with large surface area (small particle size) mopped more hydrocarbons than unactivated of the same particle size. The sorbates were mopped in the order--crude oil > diesel > kerosene > petrol. It was further observed that goat hair (keratin protein) with oleophilic and aquaphobic properties adsorbed more of all the hydrocarbons than coir at all sizes and treatment. Large quantities of the mopped oils were recovered by mere pressing while the waste sorbents with 0.5-2.0% leachable residual oil could be utilized as alternative to fire wood.

Diversity and evolution of potato mop-top virus

DEFF Research Database (Denmark)

Beuch, Ulrike; Beuch, Sofia; Åkerblom, Jonas

2015-01-01

Nearly complete sequences of RNA-CP and 3′-proximal RNA-TGB were determined for 43 samples of potato mop-top virus (PMTV) originating from potato tubers and field soil from Sweden, Denmark and the USA. The results showed limited diversity and no strict geographical grouping, suggesting only a few...

The Major Outer Membrane Protein MopB Is Required for Twitching Movement and Affects Biofilm Formation and Virulence in Two Xylella fastidiosa strains.

Science.gov (United States)

Chen, Hongyu; Kandel, Prem P; Cruz, Luisa F; Cobine, Paul A; De La Fuente, Leonardo

2017-11-01

MopB is a major outer membrane protein (OMP) in Xylella fastidiosa, a bacterial plant pathogen that causes losses on many economically important crops. Based on in silico analysis, the uncharacterized MopB protein of X. fastidiosa contains a β-barrel structure with an OmpA-like domain and a predicted calcium-binding motif. Here, MopB function was studied by mutational analysis taking advantage of the natural competence of X. fastidiosa. Mutants of mopB were constructed in two different X. fastidiosa strains, the type strain Temecula and the more virulent WM1-1. Deletion of the mopB gene impaired cell-to-cell aggregation, surface attachment, and biofilm formation in both strains. Interestingly, mopB deletion completely abolished twitching motility. Electron microscopy of the bacterial cell surface revealed that mopB deletion eliminated type IV and type I pili formation, potentially caused by destabilization of the outer membrane. Both mopB mutants showed reduced virulence using tobacco (Nicotiana tabacum) as a host under greenhouse conditions. These results suggest that MopB has pleiotropic functions in biofilm formation and twitching motility and is important for virulence of X. fastidiosa.

Pharmacokinetic and clinical comparison of two 8-methoxypsoralen brands

DEFF Research Database (Denmark)

Andersen, Klaus Ejner; Menne, T; Gammeltoft, M

1980-01-01

We compared the Danish 8-MOP brand Meladinine with the Austrial brand Oxsoralen because of our discouraging result with PUVA in treating psoriasis. Nine healthy volunteers participated in the investigation. The plasma level of 8-MOP was measured by a gas chromatogrpahic-mass spectrometric method ...

Insight into thiophene hydrodesulfurization on clean and S-modified MoP(010): a periodic density functional theory study.

Science.gov (United States)

Li, Guixia; Zhao, Lianming; Zhu, Houyu; Liu, Xiuping; Ma, Huifang; Yu, Yanchen; Guo, Wenyue

2017-07-05

The hydrodesulfurization (HDS) of thiophene on clean and S-modified MoP(010) is investigated to understand the HDS mechanism as well as the surface sulfur (S) atom effect using periodic density functional theory (DFT). The results show that thiophene prefers strongly flat adsorption on both the clean and S-modified surfaces, in either the molecular state or the dissociative state breaking simultaneously one C-S bond, and the adsorption of thiophene can be slightly weakened by the surface S atom. Thermodynamic and kinetic analysis indicates that the HDS of thiophene in both the molecular and dissociative adsorption states prefers to take place along the direct desulfurization (DDS) pathway rather than hydrogenation on both the clean and S-modified MoP(010) surfaces. Surface S shows a promotion effect on the HDS catalytic activity of MoP(010), because the energy barrier/rate constant of the rate-determining step on the DDS pathway is decreased/enlarged under the S modification. Compared with the situation of MoP(001), MoP(010) should have relatively low HDS activity, since a higher energy barrier as well as weaker exothermicity is involved in the reaction on the latter surface.

4M Overturned Pyramid (MOP Model Utilization: Case Studies on Collision in Indonesian and Japanese Maritime Traffic Systems (MTS

Directory of Open Access Journals (Sweden)

Wanginingastuti Mutmainnah

2016-07-01

Full Text Available 4M Overturned Pyramid (MOP model is a new model, proposed by authors, to characterized MTS which is adopting epidemiological model that determines causes of accidents, including not only active failures but also latent failures and barriers. This model is still being developed. One of utilization of MOP model is characterizing accidents in MTS, i.e. collision in Indonesia and Japan that is written in this paper. The aim of this paper is to show the characteristics of ship collision accidents that occur both in Indonesian and Japanese maritime traffic systems. There were 22 collision cases in 2008–2012 (8 cases in Indonesia and 14 cases in Japan. The characteristics presented in this paper show failure events at every stage of the three accident development stages (the beginning of an accident, the accident itself, and the evacuation process.

DAMPAK KEBIJAKAN PEMERINTAH TERHADAP KOMODITAS PISANG MAS KIRANA

Directory of Open Access Journals (Sweden)

Ariq Dewi Maharani

2016-10-01

Full Text Available ABSTRAKPenelitian ini bertujuan untuk menganalisis aspek profitabilitas pisang mas Kirana di Kabupaten Lumajang, dan menganalisis dampak kebijakan pemerintah terhadap pisang mas Kirana di Kabupaten Lumajang. Penentuan lokasi dilakukan secara sengaja (purposive method di Kabupaten Lumajang. Data yang digunakan meliputi data primer dan data sekunder. Analisa data menggunakan Policy Analysis Matrix (PAM untuk menganalisis aspek profitabilitas dan dampak kebijakan pemerintah terhadap pisang mas Kirana. Hasil penelitian menunjukkan bahwa Komoditas pisang mas Kirana menguntungkan secara finansial dan ekonomi yang ditunjukkan dengan keuntungan privat (PP Rp 10.444.911,8 per hektar dan keuntungan sosial (SP sebesar Rp 23.108.983,7 per hektar. Keuntungan privat pisang mas Kirana lebih kecil daripada keuntungan sosialnya (PPmas Kirana, terdapat dampak kebijakan subsidi terhadap harga-harga input pada usahatani pisang mas Kirana; masih belum ada lembaga yang dapat memberikan pelayanan yang kompetitif serta informasi yang lengkap dan rendahnya harga beli pisang mas Kirana di dalam negeri. ABSTRACTThe purpose of this research for: to analyse the aspect of profitability Kirana Mas banana and to analyse impact of government policy on Kirana Mas banana in Lumajang District. Determination of location was done intentionally or purposive method in Lumajang regency. The data that was used covering primary data and secondary data. Data analysis used Policy Analysis Matrix (PAM for knowing of profitability aspect and impact of government policy on Kirana Mas banana. The results showed that Commodity of Kirana Mas banana has financially and economically beneficial, shown by private profit (PP Rp 10,444,911.8 per hectare and social benefits (SP Rp 23,108,983.7 per hectare. Private profits of “Kirana mas” banana are smaller than social benefit (PP

Specialized bat tongue is a hemodynamic nectar mop

OpenAIRE

Harper, Cally J.; Swartz, Sharon M.; Brainerd, Elizabeth L.

2013-01-01

Nectarivorous birds and bats have evolved highly specialized tongues to gather nectar from flowers. Here, we show that a nectar-feeding bat, Glossophaga soricina, uses dynamic erectile papillae to collect nectar. In G. soricina, the tip of the tongue is covered with long filamentous papillae and resembles a brush or mop. During nectar feeding, blood vessels within the tongue tip become engorged with blood and the papillae become erect. Tumescence and papilla erection persist throughout tongue...

Sequence context effects on 8-methoxypsoralen photobinding to defined DNA fragments

International Nuclear Information System (INIS)

Sage, E.; Moustacchi, E.

1987-01-01

The photoreaction of 8-methoxypsoralen (8-MOP) with DNA fragments of defined sequence was studied. The authors took advantage of the blockage by bulky adducts of the 3'-5'-exonuclease activity associated with the T4 DNA polymerase. The action of the exonuclease is stopped by biadducts as well as by monoadducts. The termination products were analyzed on sequencing gels. A strong sequence specificity was observed in the DNA photobinding of 8-MOP. The exonuclease terminates its digestion near thymine residues, mainly at potentially cross-linkable sites. There is an increasing reactivity of thymine residues in the order T < TT << TTT in a GC environment. For thymine residues in cross-linkable sites, the reactivity follows the order AT << TA ∼ TAT << ATA < ATAT < ATATAA. Repeated A-T sequences are hot spots for the photochemical reaction of 8-MOP with DNA. Both monoadducts and interstrand cross-links are formed preferentially in 5'-TpA sites. The results highlight the role of the sequence and consequently of the conformation around a potential site in the photobinding of 8-MOP to DNA

A Ti plasmid-encoded enzyme required for degradation of mannopine is functionally homologous to the T-region-encoded enzyme required for synthesis of this opine in crown gall tumors.

Science.gov (United States)

Kim, K S; Chilton, W S; Farrand, S K

1996-06-01

The mocC gene encoded by the octopine/mannityl opine-type Ti plasmid pTi15955 is related at the nucleotide sequence level to mas1' encoded by the T region of this plasmid. While Mas1 is required for the synthesis of mannopine (MOP) by crown gall tumor cells, MocC is essential for the utilization of MOP by Agrobacterium spp. A cosmid clone of pTi15955, pYDH208, encodes mocC and confers the utilization of MOP on strain NT1 and on strain UIA5, a derivative of NT1 lacking the 450-kb cryptic plasmid pAtC58. NT1 or UIA5 harboring pYDH208 with an insertion mutation in mocC failed to utilize MOP as the sole carbon source. Plasmid pSa-C, which encodes only mocC, complemented this mutation in both strains. This plasmid also was sufficient to confer utilization of MOP on NT1 but not on UIA5. Computer analysis showed that MocC is related at the amino acid sequence level to members of the short-chain alcohol dehydrogenase family of oxidoreductases. Lysates prepared from Escherichia coli cells expressing mocC contained an enzymatic activity that oxidizes MOP to deoxyfructosyl glutamine (santhopine [SOP]) in the presence of NAD+. The reaction catalyzed by the MOP oxidoreductase is reversible; in the presence of NADH, the enzyme reduced SOP to MOP. The apparent Km values of the enzyme for MOP and SOP were 6.3 and 1.2 mM, respectively. Among analogs of MOP tested, only N-1-(1-deoxy-D-lyxityl)-L-glutamine and N-1-(1-deoxy-D-mannityl)-L-asparagine served as substrates for MOP oxidoreductase. These results indicate that mocC encodes an oxidoreductase that, as an oxidase, is essential for the catabolism of MOP. The reductase activity of this enzyme is precisely the reaction ascribed to its T-region-encoded homolog, Mas1, which is responsible for biosynthesis of mannopine in crown gall tumors.

DNA crosslinking and cell survival in human lymphoid cells treated with 8-methoxypsoralen and long wavelength ultraviolet radiation

Energy Technology Data Exchange (ETDEWEB)

Cohen, L F; Glaubiger, D L [National Cancer Inst., Bethesda, MD (USA). Pediatric Oncology Branch; Kraemer, K H; Waters, H L [National Cancer Inst., Bethesda, MD (USA). Lab. of Molecular Carcinogenesis; Kohn, K W [National Cancer Inst., Bethesda, MD (USA). Lab. of Molecular Pharmacology

1981-01-01

8-Methoxypsoralen (8-MOP) when irradiated with long wavelength ultraviolet radiation (UV-A) inhibits DNA synthesis in lymphocytes in vitro and in vivo. 8-MOP binds reversibly to DNA in the dark; when exposed to UV-A, covalent monoadducts and cross-links are formed with the DNA. The present study correlates the cytotoxic effects of 8-MOP plus UV-A with DNA crosslinking. E-B virus transformed human lymphoblastoid cells were suspended in a colorless salt solution containing 8-MOP and exposed to UV-A from fluorescent lamps filtered to remove radiation below 320 nm (22.5 J/m/sup 2/-sec). Cells were then returned to complete medium and assayed for survival (by daily counts of viable cells and by cloning in microtiter wells) and for DNA crosslinking by alkaline elution. 8-MOP alone or UV-A alone resulted in minimal to no alterations in survivial or in DNA crosslinking. DNA crosslinking was found to be linearly dependent on 8-MOP concentration (in the range of 0.01-1.0 ..mu..g/ml) for 3 different UV-A doses (3000-15000 J/m/sup 2/). The surviving fraction declined exponentially as a function of the relative number of DNA crosslinks.

A Ti plasmid-encoded enzyme required for degradation of mannopine is functionally homologous to the T-region-encoded enzyme required for synthesis of this opine in crown gall tumors.

OpenAIRE

Kim, K S; Chilton, W S; Farrand, S K

1996-01-01

The mocC gene encoded by the octopine/mannityl opine-type Ti plasmid pTi15955 is related at the nucleotide sequence level to mas1' encoded by the T region of this plasmid. While Mas1 is required for the synthesis of mannopine (MOP) by crown gall tumor cells, MocC is essential for the utilization of MOP by Agrobacterium spp. A cosmid clone of pTi15955, pYDH208, encodes mocC and confers the utilization of MOP on strain NT1 and on strain UIA5, a derivative of NT1 lacking the 450-kb cryptic plasm...

Ti plasmid-encoded genes responsible for catabolism of the crown gall opine mannopine by Agrobacterium tumefaciens are homologs of the T-region genes responsible for synthesis of this opine by the plant tumor.

Science.gov (United States)

Kim, K S; Farrand, S K

1996-06-01

Agrobacterium tumefaciens NT1 harboring pSaB4, which contains the 14-kb BamHI fragment 4 from the octopine/mannityl opine-type Ti plasmid pTi15955, grew well with agropine (AGR) but slowly with mannopine (MOP) as the sole carbon source. When a second plasmid encoding a dedicated transport system for MOP was introduced, these cells grew well with both AGR and MOP. Transposon insertion mutagenesis and subcloning identified a 5.7-kb region of BamHI fragment 4 that encodes functions required for the degradation of MOP. DNA sequence analysis revealed seven putative genes in this region: mocD (moc for mannityl opine catabolism) and mocE, oriented from right to left, and mocRCBAS, oriented from left to right. Significant identities exist at the nucleotide and derived amino acid sequence levels between these moc genes and the mas genes that are responsible for opine biosynthesis in crown gall tumors. MocD is a homolog of Mas2, the anabolic conjugase encoded by mas2'. MocE and MocC are related to the amino half and the carboxyl half, respectively, of Mas1 (MOP reductase), the second enzyme for MOP biosynthesis. These results indicate that the moc and mas genes evolved from a common origin. MocR and MocS are related to each other and to a putative repressor for the AGR degradation system encoded by the rhizogenic plasmid pRiA4. MocB and MocA are homologs of 6-phosphogluconate dehydratase and glucose-6-phosphate dehydrogenase, respectively. Mutations in mocD and mocE, but not mocC, are suppressed by functions encoded by the chromosome or the 450-kb megaplasmid present in many Agrobacterium isolates. We propose that moc genes derived from genes located elsewhere in the bacterial genome and that the tumor-expressed mas genes evolved from the bacterial moc genes.

cn.MOPS: mixture of Poissons for discovering copy number variations in next-generation sequencing data with a low false discovery rate.

Science.gov (United States)

Klambauer, Günter; Schwarzbauer, Karin; Mayr, Andreas; Clevert, Djork-Arné; Mitterecker, Andreas; Bodenhofer, Ulrich; Hochreiter, Sepp

2012-05-01

Quantitative analyses of next-generation sequencing (NGS) data, such as the detection of copy number variations (CNVs), remain challenging. Current methods detect CNVs as changes in the depth of coverage along chromosomes. Technological or genomic variations in the depth of coverage thus lead to a high false discovery rate (FDR), even upon correction for GC content. In the context of association studies between CNVs and disease, a high FDR means many false CNVs, thereby decreasing the discovery power of the study after correction for multiple testing. We propose 'Copy Number estimation by a Mixture Of PoissonS' (cn.MOPS), a data processing pipeline for CNV detection in NGS data. In contrast to previous approaches, cn.MOPS incorporates modeling of depths of coverage across samples at each genomic position. Therefore, cn.MOPS is not affected by read count variations along chromosomes. Using a Bayesian approach, cn.MOPS decomposes variations in the depth of coverage across samples into integer copy numbers and noise by means of its mixture components and Poisson distributions, respectively. The noise estimate allows for reducing the FDR by filtering out detections having high noise that are likely to be false detections. We compared cn.MOPS with the five most popular methods for CNV detection in NGS data using four benchmark datasets: (i) simulated data, (ii) NGS data from a male HapMap individual with implanted CNVs from the X chromosome, (iii) data from HapMap individuals with known CNVs, (iv) high coverage data from the 1000 Genomes Project. cn.MOPS outperformed its five competitors in terms of precision (1-FDR) and recall for both gains and losses in all benchmark data sets. The software cn.MOPS is publicly available as an R package at http://www.bioinf.jku.at/software/cnmops/ and at Bioconductor.

4,4',5'-trimethyl-8-azapsoralen, a new-photoreactive and non-skin-phototoxic bifunctional bioisoster of psoralen.

Science.gov (United States)

Vedaldi, D; Dall'Acqua, F; Caffieri, S; Baccichetti, F; Carlassare, F; Bordin, F; Chilin, A; Guiotto, A

1991-01-01

Photochemical and photobiological properties of a new isoster of psoralen, 4,4',5'-trimethyl-8-azapsoralen (4,4',5'-TMAP), have been studied. This compound shows a high DNA-photobinding rate, higher than that of 8-methoxypsoralen (8-MOP), forming both monoadducts and inter-strand cross-links. The yield of cross-links, however, is markedly lower than that of 8-MOP. Antiproliferative activity of 4,4',5'-TMAP, in terms of DNA synthesis inhibition in Ehrlich ascites tumor cells, is higher than that of 8-MOP. Mutagenic activity on E. coli WP2 R46+ cells appeared similar to or even lower than that of 8-MOP. This new compound applied on depilated guinea pig skin and irradiated with UVA did not show any skin-phototoxicity. On the basis of these properties 4,4',5'-TMAP appears to be a potential photochemotherapeutic agent.

POLYCLONAL ANTIBODIES TO DETECT THE CP-RT PROTEIN OF Potato Mop-Top VIRUS ANTICUERPOS POLICLONALES PARA LA DETECCIÓN DE LA PROTEÍNA CP-RT DEL Potato Mop-Top VIRUS

Directory of Open Access Journals (Sweden)

Derly Andrade Molina

2012-06-01

Full Text Available Abstract. Potato mop-top virus (PMTV causes an important re-emerging disease in potato crops in Colombia due to the increased incidence of its protozoan vector Spongospora subterranea f.sp. subterranea (Sss, the causing agent of Powdery scab disease. For an accurate detection of PMTV it is recommended to combine different diagnostic tests and evaluate multiple samples per plant or tissue. In order to increase the number of available tools for detection of PMTV, antibodies targeting the RT domain of the CP-RT protein were developed in this work. Sequencing of the RT domain from the colombian strain R25 was achieved and using bioinformatic analysis, a potential antigenic region was identified. A peptide mimicking the antigenic region was inoculated in rabbits for the production of polyclonal antibodies. The antibodies were tested by ELISA using Nicotiana benthamiana bait-plants infected with Sss cystosori and potato plants collected in La Unión (Antioquia. The validity of serological tests was confirmed by RT-PCR. A complete sequence of the RT domain and 441 nt of the CP gene were obtained. Phylogenetic analysis identified strain R25 as closely associated to the PMTV lineage distributed worldwide. A total of 19.26 mg of anti-CP-RT polyclonal antibodies useful in detecting PMTV in infected plants were obtained. As CP-RT is involved in transmission of PMTV by Sss, these antibodies will be useful for supporting not only diagnostic programs but also basic and epidemiologic studies aimed at understanding interactions between PMTV and Sss.Resumen. El Potato mop-top virus (PMTV es uno de los virus re-emergentes en los cultivos de papa de Colombia, como resultado del aumento de la incidencia de su vector natural, el protozoo Spongospora subterranea f.sp. mamarinm@unal.edu.co (Sss, agente causal de la Sarna polvosa de la papa. Para la detección del virus se recomienda la realización simultánea de diferentes pruebas, así como la evaluación de m

El Proyecto Sismico "LARSE" - Trabajando Hacia un Futuro con Mas Seguridad para Los Angeles

Science.gov (United States)

Henyey, Thomas L.; Fuis, Gary S.; Benthien, Mark L.; Burdette, Thomas R.; Christofferson, Shari A.; Clayton, Robert W.; Criley, Edward E.; Davis, Paul M.; Hendley, James W.; Kohler, Monica D.; Lutter, William J.; McRaney, John K.; Murphy, Janice M.; Okaya, David A.; Ryberg, Trond; Simila, Gerald W.; Stauffer, Peter H.

1999-01-01

La region de Los Angeles contiene una red de fallas activas, incluyendo muchas fallas por empuje que son profundas y no rompen la superficie de la tierra. Estas fallas ocultas incluyen la falla anteriormente desconocida que fue responsable por la devastacion que ocurrio durante el terremoto de Northridge en enero de 1994, el terremoto mas costoso en la historia de los Estados Unidos. El Experimento Sismico en la Region de Los Angeles (Los Angeles Region Seismic Experiment, LARSE), esta localizando los peligros ocultos de los terremotos debajo de la region de Los Angeles para mejorar la construccion de las estructuras que pueden apoyar terremotos que son inevitables en el futuro, y que ayudaran a los cientificos determinar donde occurira el sacudimento mas fuerte y poderoso.

Kinetics of [14C-5] 8-methoxypsoralen uptake by UVA irradiated and non-irradiated rabbit eye tissues

International Nuclear Information System (INIS)

Malinin, G.I.; Glew, W.B.; Roberts, W.P.; Nigra, T.P.

1981-01-01

Total 8-methoxypsoralen (8-MOP) in intact and UVA irradiated rabbit eye tissues and its unaltered fraction in aqueous and eye lenses were determined over the 24 hours after i.v. injection of [ 14 C-5] and carrier 8-MOP at the concentration of 50 microCi and 5 mg/kg. No 8-MOP was detected at the end of 24 hours in intact and irradiated aqueous, vitreous and retina in contrast to one hour when the respective levels were congruent to 220, greater than 0 and congruent to 160 ng/g. Eye-plasma drug concentration ratios were less than 0.5 initially, but increased thereafter. While the average lens 8-MOP levels of congruent to 140 ng/g remained unchanged for 24 hours, no unaltered drug was detected beyond eight hours. Measurable amounts of label at the end of 24 hours also persisted in the cornea, iris, sclera and conjunctiva

Pharmacokinetic comparison of seven 8-methoxypsoralen brands

DEFF Research Database (Denmark)

Menne, T; Andersen, Klaus Ejner; Larsen, E

1981-01-01

The pharmacokinetics of seven 8-MOP brands were evaluated in 7 volunteers using an incomplete bloc design. After a single oral dose the 8-MOP plasma level was followed for 3 hours. The plasma concentration was measured with a gas chromatographic - mass spectrometric method, using an isotopic...... dilution technique. The different brands could be divided into three groups. Two gave a high maximum concentration, four a medium, and one a low concentration. The large interbrand variation observed in this study can explain the variations in the results of the treatment and the differing numbers...

Ionic liquid-doped polyaniline and its redox activities in the zwitterionic biological buffer MOPS

International Nuclear Information System (INIS)

Qu, Ke; Zeng, Xiangqun

2016-01-01

The electropolymerization of aniline in several common imidazolium-based ionic liquids has been accomplished successfully with the potentiodynamic method. Considering the fact that imidazolium-based ionic liquids are acidic, they have been selected as the electrolyte for the electropolymerization of aniline, eliminating the usage of extra inorganic or organic acids. The ionic liquids not only serve as the reaction media, exerting the unique favorable π-π interactions between the imidazolium rings and benzene rings of aniline monomer or the growing polymer, but also act as the dopants to render different properties to the resulting polyaniline. Among the tested imidazolium-based ionic liquids, [BMIM][BF_4], [BMIM][PF_6], [BMIM][NTf_2], [EMIM][ES] and [HMIM][FAP], polyaniline doped by the hydrophilic ionic liquid [BMIM][BF_4] displays the good electrochemical responses in the biologically important MOPS (3-(N-Morpholino)-propanesulfonic acid) solution with 2.34 × 10"−"3 M of sulfuric acid additive. NMR, UV–vis and electrochemical impedance experiments were performed to further characterize the polyaniline/[BMIM][BF_4] composite. In contrast, polyaniline that is doped by the hydrophobic ionic liquid [BMIM][PF_6] is electroactive in the MOPS solution in the absence of the acid additive, with a pH of 5, extending the working pH range of polyaniline, which is typically electroactive in the solutions with the pH values less than 3. It is suggested that the effective hydrogen bonding interactions between BF_4 anion and water facilitate its hydrolysis in the microenvironment of the polymer backbone to provide the acidic protons, which are beneficial to the adjustment of the microenvironments of the polyaniline system and thus renders its observed well-resolved reversible pair of redox peaks in the MOPS solution. PF_6 anion, on the other hand, with its larger size and less basicity, has the weaker interaction with water, thus releasing the protons in a relatively slow

8-MOP PUVA for psoriasis: a comparison of a minimal phototoxic dose-based regimen with a skin-type approach

Energy Technology Data Exchange (ETDEWEB)

Collins, P.; Wainwright, N.J.; Amorim, I.; Lakshmipathi, T.; Ferguson, J. [Ninewells Hospital and Medical School, Dundee (United Kingdom)

1996-08-01

Two ultraviolet A (UVA) regimens for oral 8-methoxypsoralen (8-MOP) photochemotherapy (PUVA) for moderate/severe chronic plaque psoriasis using a half-body study technique were compared. Each patient received both regimens. A higher-dose regimen based on minimal phototoxic dose (MPD) with percentage incremental increases was given to one-half of the body. The other half received a lower dose regimen based on skin type with fixed incremental UVA increases. Patients were treated twice weekly. Symmetrical plaques were scored to determine the rate of resolution with each regimen. In addition, the number of treatments, cumulative UVA dose and number of days in treatment to achieve overall clearance were recorded. Patients were reviewed monthly for one year to record remission data. Thirty-three patients completed the study. Both regimens were effective and well tolerated. With the MPD-based approach, number of exposures was significantly less for patients with skin types I and II but not III. Although the cumulative UVA dose was higher with the MPD regimen for all skin types studied, the reduced number of exposures required for clearance for skin types I and II but not III, combined with the security of individualized MPD testing, has practical attractions. MPD testing also identified five patients who required an increased psoralen dose and six patients who required a reduction of the initial UVA dose with the skin type regimen. Forty-two percent were still clear 1 year after treatment and there was no significant difference in the number of days in remission between the regimens for those whose psoriasis had recurred. The reduction in the number of exposures required for clearance with the MPD-based regimen may be safer and more cost effective in the long term. (author).

E/Z MAS demonstration

International Nuclear Information System (INIS)

Boor, M.G.; Hurford, J.M.; Landry, R.P.; Martinez, B.J.; Solem, A.M.; Whiteson, R.; Zardecki, A.

1998-01-01

Los Alamos National Laboratory has developed E/Z MAS, a new generation nuclear material accountability application based on the latest technology and designed for facilities required to track nuclear materials with a simple-to-use interface. E/Z MAS is based on years of experience spent developing nuclear material accounting systems. E/Z MAS uses a modern relational database with a web server and enables users on a classified local area network to interact with the database with web browsers. The E/Z MAS Demonstration poster session demonstrates the E/Z MAS functions required by an operational nuclear facility to track material as it enters and leaves a facility and to account for the material as it moves through a process. The generation of internal facility reports and external reports for the Russian Federal system will be demonstrated. Bar-code readers will be used to demonstrate the ability of EZ MAS to automate certain functions, such as physical inventories at facilities

(Liquid + liquid), (solid + liquid), and (solid + liquid + liquid) equilibria of systems containing cyclic ether (tetrahydrofuran or 1,3-dioxolane), water, and a biological buffer MOPS

International Nuclear Information System (INIS)

Altway, Saidah; Taha, Mohamed; Lee, Ming-Jer

2015-01-01

Graphical abstract: - Highlights: • MOPS buffer induced liquid phase splitting for mixtures of water with THF or 1,3-dioxolane. • Phase boundaries of LLE, SLE, and SLLE were determined experimentally. • Tie-lines at LLE and at SLLE were also measured. • Phase diagrams of MOPS + water + THF or 1,3-dioxolane are prepared. • LLE tie-line data are correlated satisfactorily with the NRTL model. - Abstract: Two liquid phases were formed as the addition of a certain amount of biological buffer 3-(N-morpholino)propane sulfonic acid (MOPS) in the aqueous solutions of tetrahydrofuran (THF) or 1,3-dioxolane. To evaluate the feasibility of recovering the cyclic ethers from their aqueous solutions with the aid of MOPS, we determined experimentally the phase diagrams of the ternary systems of {cyclic ether (THF or 1,3-dioxolane) + water + MOPS} at T = 298.15 K under atmospheric pressure. In this study, the solubility data of MOPS in water and in the mixed solvents of water/cyclic ethers were obtained from the results of a series of density measurements, while the (liquid + liquid) and the (solid + liquid + liquid) phase boundaries were determined by visually inspection. Additionally, the tie-line results for (liquid + liquid) equilibrium (LLE) and for (solid + liquid + liquid) equilibrium (SLLE) were measured using an analytical method. The reliability of the experimental LLE tie-line results data was validated by using the Othmer–Tobias correlation. These LLE tie-line values were correlated well with the NRTL model. The phase diagrams obtained from this study reveal that MOPS is a feasible green auxiliary agent to recover the cyclic ethers from their aqueous solutions, especially for 1,3-dioxolane

Volumetric properties of MES, MOPS, MOPSO, and MOBS in water and in aqueous electrolyte solutions

International Nuclear Information System (INIS)

Taha, Mohamed; Lee, Ming-Jer

2010-01-01

4-Morpholineethanesulfonic acid (MES), 4-morpholinepropanesulfonic acid (MOPS), 3-morpholino-2-hydroxypropanesulfonic acid (MOPSO), and 4-(N-morpholino)butanesulfonic acid (MOBS), are useful for pH control as standard buffers in the physiological region of 5.5-6.7 for MES, 6.5-7.9 for MOPS, 6.2-7.6 for MOPSO, and 6.9-8.3 for MOBS, respectively. On the basis of density measurements at 298.15 K, the apparent molar volumes, V φ , of the above-mentioned buffers in water and in (0.05, 0.16, and 0.25) mol kg -1 aqueous solutions of NaCl, KCl, KBr, and CH 3 COOK have been calculated. The partial molar volumes at infinite dilution, V φ o , obtained from V φ , have been used to calculate the volume of transfer, Δ tr V φ o , from water to aqueous electrolyte solutions. It was found that both V φ o and Δ tr V φ o vary linearly with increasing the number of carbon atoms in the alkyl group side chain of the zwitterionic buffers. These linear correlations have been utilized to estimate the contributions of the zwitterionic end group (morpholinium ion, -SO 3 - ) and -CH 2 - group to V φ o and Δ tr V φ o . The values of V φ o and Δ tr V φ o for some functional group contributions of the zwittierionic buffers with salts have also been reported.

4M Overturned Pyramid (MOP) Model Utilization: Case Studies on Collision in Indonesian and Japanese Maritime Traffic Systems (MTS)

OpenAIRE

Wanginingastuti Mutmainnah; Masao Furusho

2016-01-01

4M Overturned Pyramid (MOP) model is a new model, proposed by authors, to characterized MTS which is adopting epidemiological model that determines causes of accidents, including not only active failures but also latent failures and barriers. This model is still being developed. One of utilization of MOP model is characterizing accidents in MTS, i.e. collision in Indonesia and Japan that is written in this paper. The aim of this paper is to show the characteristics of ship collision accidents...

Enhancement of 8-methoxypsoralen topical delivery via nanosized niosomal vesicles: Formulation development, in vitro and in vivo evaluation of skin deposition.

Science.gov (United States)

Kassem, Ahmed Alaa; Abd El-Alim, Sameh Hosam; Asfour, Marwa Hasanein

2017-01-30

The aim of the present study is to enhance the skin penetration and deposition of 8-methoxypsoraln (8-MOP) via niosomal vesicles to increase its local efficacy and safety. 8-MOP niosomes were prepared by the thin film hydration method using Span 60 or Span 40 along with cholesterol at five different molar ratios. The obtained vesicles revealed high entrapment efficiencies (83.04-89.90%) with nanometric vesicle diameters (111.1-198.8nm) of monodisperse distribution (PDI=0.145-0.216), zeta potential values <-48.3mV and spherical morphology under transmission electron microscopy. Optimized niosomal formulations depicted a biphasic in vitro release pattern in phosphate buffer (pH 5.5)/ethanol (7:3v/v) and displayed good physical stability after storage for 6 months at room (20-25°C) and refrigeration (4-8°C) temperatures. The two optimized formulations were incorporated in 5% sodium carboxy methylcellulose based hydrogel matrix which showed optimum pH values (7.37-7.39), pseudoplastic with thixotropic rheological behavior and more retarded 8-MOP release, by 23.82 and 14.89%, compared to niosomal vesicles after 24h. In vitro drug permeation and deposition studies, using rat skins, revealed promoted penetration and accumulation of 8-MOP after 8h. The skin penetration was further confirmed in vivo by confocal laser scanning microscopy, after 2h application period using rhodamine-loaded niosomal hydrogels compared to plain rhodamine hydrogel, as a florescence marker. Therefore, enhanced permeation and skin deposition of 8-MOP delivered by niosomes may help in improving the efficacy and safety of long-term treatment with 8-MOP. Copyright © 2016 Elsevier B.V. All rights reserved.

The Development of Marine Accidents Human Reliability Assessment Approach: HEART Methodology and MOP Model

Directory of Open Access Journals (Sweden)

Ludfi Pratiwi Bowo

2017-06-01

Full Text Available Humans are one of the important factors in the assessment of accidents, particularly marine accidents. Hence, studies are conducted to assess the contribution of human factors in accidents. There are two generations of Human Reliability Assessment (HRA that have been developed. Those methodologies are classified by the differences of viewpoints of problem-solving, as the first generation and second generation. The accident analysis can be determined using three techniques of analysis; sequential techniques, epidemiological techniques and systemic techniques, where the marine accidents are included in the epidemiological technique. This study compares the Human Error Assessment and Reduction Technique (HEART methodology and the 4M Overturned Pyramid (MOP model, which are applied to assess marine accidents. Furthermore, the MOP model can effectively describe the relationships of other factors which affect the accidents; whereas, the HEART methodology is only focused on human factors.

Solubility and phase separation of 4-morpholinepropanesulfonic acid (MOPS), and 3-morpholino-2-hydroxypropanesulfonic acid (MOPSO) in aqueous 1,4-dioxane and ethanol solutions

International Nuclear Information System (INIS)

Taha, Mohamed; Lee, Ming-Jer

2011-01-01

Highlights: → Solubilities of MOPS and MOPSO buffers in aqueous 1,4-dioxane and ethanol solutions. → We found that MOPS-induced phase separation of aqueous solution of 1,4-dioxane. → The phase diagram of (MOPS + water + 1,4-dioxane) system at 298.15 K is documented. → The tie-lines within the two-liquid phase region were also determined at 298.15 K. → The effective excluded volume theory was applied to correlate the binodal LLE data. - Abstract: The buffers 4-morpholinepropanesulfonic acid (MOPS) and 3-morpholino-2-hydroxypropanesulfonic acid (MOPSO) are useful biological zwitterionic buffers within the pH range of 6.5 to 7.9 and 6.2 to 7.6, respectively. The solubilities of these buffers were determined in binary mixtures (1,4-dioxane + water) and (ethanol + water) at T = 298.15 K by using the results of density measurements. It has been observed that MOPS induced liquid-liquid phase splitting for the mixtures of 40% to 90% (w/w) 1,4-dioxane in water. The two-liquid phase formation was visualized with disperse orange 25. The phase equilibrium boundaries, including the regions of one liquid, two liquids, (one liquid + one solid) and (two liquids + one solid), for the (MOPS + water + 1,4-dioxane) system have been determined experimentally at T = 298.15 K. The tie lines of the (liquid + liquid) equilibrium were also measured. The Othmer-Tobias and Bancroft equation were used to evaluate the reliability of the tie-line data. The binodal curve was fitted to an empirical equation and the effective excluded volume (EEV) model. The apparent free energies of transfer (ΔG tr ' ) of MOPS and MOPSO from water to 1,4-dioxane and ethanol solutions have been calculated from the solubility data. These ΔG tr ' values were compared with those of some related biological buffers (TRIS, TAPS, TAPSO, and TABS). Furthermore, we also calculated the contribution of transfer free energies (Δg tr ' ) of -OH group from water to 1,4-dioxane and ethanol solutions.

Comparative studies on the lethal, mutagenic, and recombinogenic effects of ultraviolet -A, -B, -C, and visible light with and without 8-methoxypsoralen in Saccharomyces cerevisiae

International Nuclear Information System (INIS)

Mondon, P.; Shahin, M.M.

1992-01-01

Genetic effects of UV-A, UV-B, UV-C and the combination of 8-methoxypsoralen (8-MOP) with UV-A or visible light were studied in the haploid strain XV185-14C and diploid strain D5 of Saccharomyces cerevisiae. The induction of his + , lys + , and hom + reverse mutations was measured in strain XV185-14C. In strain D5 we measured the induction of genetically altered colonies, particularly twin spot colonies arising from a mitotic crossing-over. UV-C and UV-B induced point mutations at the three loci in the haploid strain and mitotic crossing-over and other genetic alterations in the diploid strain. UV-C was more mutagenic and recombinogenic than UV-B. UV-A or visible light alone did not induce genotoxic effects at the doses tested. However, UV-A plus 8-MOP produced lethal and mutagenic effects in the haploid strain XV185-14C, although mutagenic activity was less than that of UV-B. Visible light plus 8-MOP also induced genotoxic effects in strain XV185-14C. In the diploid strain D5, UV-A plus 8-MOP induced a higher frequency of genetic alterations than UV-B at comparative doses. Visible light plus 8-MOP was also genetically active in strain D5. The haploid strain was more sensitive to the lethal effects of UV-C, UV-B, UV-A, and impure visible light plus 8-MOP than the diploid strain. (Author)

[Genetic control of mitotic crossing-over in yeasts. III. Induction by 8-methoxypsoralen and long-wave UV irradiation (lambda=365 nm)].

Science.gov (United States)

Fedorova, I V; Marfin, S V

1982-02-01

The lethal effect of 8-methoxypsoralen (8-MOP) plus 365 nm light has been studied in haploid radiosensitive strains of Saccharomyces cerevisiae. The diploid of wild type and the diploid homozygous for the rad2 mutation (this mutation blocks the excision of UV-induced pyrimidine dimers) were more resistant to the lethal effect of 8-MOP plus 365 nm light than the haploid of wild type and rad2 haploid, respectively. The diploid homozygous for rad54 mutation (the mutation blocks the repair of double-strand breaks in DNA) was more sensitive than haploid rad54. The method of repeated irradiation allowed to study the capacity of radiosensitive diploids to remove monoadducts induced by 8-MOP in DNA. This process was very effective in diploids of wild type and in the rad54 rad54 diploid, while the rad2 rad2 diploid was characterized by nearly complete absence of monoadduct excision. The study of mitotic crossing over and mitotic segregation in yeast diploids, containing a pair of complementing alleles of the ade2 gene (red/pink) has shown a very high recombinogenic effect of 8-MOP plus 365 nm light. The rad2 mutation slightly increased the frequency of mitotic segregation and mitotic crossing over. The rad54 mutation decreased the frequency of mitotic segregation and entirely suppressed mitotic crossing over. The method of repeated irradiation showed that the cross-links, but not monoadducts, are the main cause of high recombinogenic effect of 8-MOP plus 365 nm light. The possible participation of different repair systems in recombinational processes induced by 8-MOP in yeast cells is discussed.

A General Protocol for Temperature Calibration of MAS NMR Probes at Arbitrary Spinning Speeds

Science.gov (United States)

Guan, Xudong; Stark, Ruth E.

2010-01-01

A protocol using 207Pb NMR of solid lead nitrate was developed to determine the temperature of magic-angle spinning (MAS) NMR probes over a range of nominal set temperatures and spinning speeds. Using BioMAS and fastMAS probes with typical sample spinning rates of 8 and 35 kHz, respectively, empirical equations were devised to predict the respective sample temperatures. These procedures provide a straightforward recipe for temperature calibration of any MAS probe. PMID:21036557

Production of Polyclonal Antibodies to a Recombinant Coat Protein of Potato mop-top virus

Czech Academy of Sciences Publication Activity Database

Čeřovská, Noemi; Moravec, Tomáš; Rosecká, Pavla; Dědič, P.; Filigarová, Marie

2003-01-01

Roč. 151, č. 4 (2003), s. 195-200 ISSN 0931-1785 R&D Projects: GA ČR GA522/01/1121 Institutional research plan: CEZ:AV0Z5038910 Keywords : potato mop-top virus * recombinant coat protein * Escherichia Coli Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 0.557, year: 2003

Effect of 8-methoxypsoralen-plus ultraviolet light on cell-virus interaction: the transforming infection; effect of PUVA on the transformation of baby hamster kidney cells by polyma virus

International Nuclear Information System (INIS)

Morhenn, V.B.; Kaye, J.A.

1979-01-01

Pre-treatment of baby hamster kidney (BHK) cells with 8-methoxypsoralen (8-MOP) plus ultraviolet (UV) light enhances the frequency of their transformation by polyoma (Py) virus. Of the doses tested, 0.5 microgram/m1 8-MOP plus 0 . 3 J/cm2 UV-light results in maximal (30-fold) stimulation of viral transformation. 8-MOP alone does not affect viral transformation and UV-light alone causes only a slight increase in the transformation frequency. Thus the drug and light act synergistically in promoting the effect. Treatment of BHK cells with drug plus light without Py infection does not lead to a transformed morphology. A drug-light combination (0 . 01 microgram/m1 8-MOP plus 1 . 2 J/cm2 UV) that inhibits cellular DNA synthesis is 75% of control at 28 hr after treatment results in a 6-fold stimulation of the transformation frequency

Repair of 8-methoxypsoralen + UVA-induced damage in specific sequences in chromosomal and episomal DNA in human cells

Energy Technology Data Exchange (ETDEWEB)

Dean, S.W.

1989-07-01

A study of the repair of DNA damage in the dihydrofolate reductase (dhfr) gene of SV40-transformed human fibroblasts after treatment with 8-methoxypsoralen (8MOP) and UVA is described. 8MOP+UVA-induced cross-links in the dhfr gene were completely repaired by 12 h in one normal and one Fanconi's anaemia (FA) group A cell line. In contrast, approximately 35% of cross-links in an episomally maintained Epstein--Barr virus derived plasmid remained unrepaired even after 48 h. Cross-linkable monoadducts in the dhfr gene were repaired more slowly than cross-links, and there was no detectable repair of cross-linkable monoadducts in the plasmid. Thus the ability of a cell to repair 8MOP+UVA-induced cross-links or cross-linkable monoadducts in an episome does not reflect its capacity to repair such lesions in genomic DNA.

Repair of 8-methoxypsoralen + UVA-induced damage in specific sequences in chromosomal and episomal DNA in human cells

International Nuclear Information System (INIS)

Dean, S.W.

1989-01-01

A study of the repair of DNA damage in the dihydrofolate reductase (dhfr) gene of SV40-transformed human fibroblasts after treatment with 8-methoxypsoralen (8MOP) and UVA is described. 8MOP+UVA-induced cross-links in the dhfr gene were completely repaired by 12 h in one normal and one Fanconi's anaemia (FA) group A cell line. In contrast, ∼35% of cross-links in an episomally maintained Epstein-Barr virus derived plasmid remained unrepaired even after 48 h. Cross-linkable monoadducts in the dhfr gene were repaired more slowly than cross-links, and there was no detectable repair of cross-linkable monoadducts in the plasmid. Thus the ability of a cell to repair 8MOP+UVA-induced cross-links or cross-linkable monoadducts in an episome does not reflect its capacity to repair such lesions in genomic DNA. (author)

Un lote de armamento ibérico procedente de la necrópolis del Mas de Barberán (Nogueruelas, Teruel

Directory of Open Access Journals (Sweden)

Izquierdo Peraile, Isabel

1999-12-01

Full Text Available In this paper we publish an Ibenan set of weapons -swords, lances and dagger essentially-, coming from the cemetery of the settlement so-called Mas de Barberán (Nogueruelas, Teruel. An anthropomorphic stele with an inscription recently studied is associated to the same site. This stele represents an armed with disk-cuirass masculine personage.

En este trabajo presentamos un lote inédito de armamento ibérico espadas, lanzas y puñal esencialmente procedente de la necrópolis correspondiente al poblado del Mas de Barberán (Nogueruelas, Teruel. Al mismo yacimiento se asocia la estela antropomorfa con inscripción que representa un personaje masculino armado con disco-coraza, recientemente estudiada.

Fluid flow dynamics in MAS systems

Science.gov (United States)

Wilhelm, Dirk; Purea, Armin; Engelke, Frank

2015-08-01

The turbine system and the radial bearing of a high performance magic angle spinning (MAS) probe with 1.3 mm-rotor diameter has been analyzed for spinning rates up to 67 kHz. We focused mainly on the fluid flow properties of the MAS system. Therefore, computational fluid dynamics (CFD) simulations and fluid measurements of the turbine and the radial bearings have been performed. CFD simulation and measurement results of the 1.3 mm-MAS rotor system show relatively low efficiency (about 25%) compared to standard turbo machines outside the realm of MAS. However, in particular, MAS turbines are mainly optimized for speed and stability instead of efficiency. We have compared MAS systems for rotor diameter of 1.3-7 mm converted to dimensionless values with classical turbomachinery systems showing that the operation parameters (rotor diameter, inlet mass flow, spinning rate) are in the favorable range. This dimensionless analysis also supports radial turbines for low speed MAS probes and diagonal turbines for high speed MAS probes. Consequently, a change from Pelton type MAS turbines to diagonal turbines might be worth considering for high speed applications. CFD simulations of the radial bearings have been compared with basic theoretical values proposing considerably smaller frictional loss values. The discrepancies might be due to the simple linear flow profile employed for the theoretical model. Frictional losses generated inside the radial bearings result in undesired heat-up of the rotor. The rotor surface temperature distribution computed by CFD simulations show a large temperature gradient over the rotor.

Transportation Structure Analysis Using SD-MOP in World Modern Garden City: A Case Study in China

Directory of Open Access Journals (Sweden)

Jiuping Xu

2012-01-01

Full Text Available The idea of the “garden city” was developed theoretically to offer solutions to serious city development problems such as traffic congestion, population, and environmental pollution, among which the transportation is considered the most important. The question is how to develop balanced transportation in a garden city. Transportation is a complex system, particularly in a garden city. Therefore, we establish a new approach named the transportation multiobjective optimization system dynamics  (SD-MOP model, which firstly calculates the optimal proportion of different transport means with an MOP approach and then applies them to the dynamic transportation system to analyze the results and analyze the influence on the whole system using different transportation means variation. In this paper, we take Chengdu as an example, one of the few cities in the world declared as building a garden city, and then develop some recommendations about world modern garden city transportation system development.

Mutagenic effects of 3-carbethoxypsoralen and 8-methoxypsoralen plus 365-nm irradiation in mammalian cells

International Nuclear Information System (INIS)

Papadopoulo, D.; Sagliocco, F.; Averbeck, D.

1983-01-01

Cell survival, i.e. colony-forming ability, and the induction of 6-thioguanine-resistant (6-TGsup(r)) mutants were determined in Chinese hamster V79 cells by using two photoreactive furocoumarins of photochemotherapeutic interest: the bifunctional compound 8-methoxypsoralen (8-MOP) and the monofunctional compound 3-carbethoxypsoralen (3-CPs). To quantify the mutation induction in V79 cells mutants deficient in the enzyme hypoxanthine-guanine phosphoribosyl transferase (HGPRT) were selected with the purine analogue 6-thioguanine (6-TG). Both compounds exhibited lethal and mutagenic activities but the monofunctional compound 3-CPs was less lethal and mutagenic than the bifunctional compound 8-MOP. (Auth.)

Evidence for Heterodimerization and Functional Interaction of the Angiotensin Type 2 Receptor and the Receptor MAS.

Science.gov (United States)

Leonhardt, Julia; Villela, Daniel C; Teichmann, Anke; Münter, Lisa-Marie; Mayer, Magnus C; Mardahl, Maibritt; Kirsch, Sebastian; Namsolleck, Pawel; Lucht, Kristin; Benz, Verena; Alenina, Natalia; Daniell, Nicholas; Horiuchi, Masatsugu; Iwai, Masaru; Multhaup, Gerhard; Schülein, Ralf; Bader, Michael; Santos, Robson A; Unger, Thomas; Steckelings, Ulrike Muscha

2017-06-01

The angiotensin type 2 receptor (AT2R) and the receptor MAS are receptors of the protective arm of the renin-angiotensin system. They mediate strikingly similar actions. Moreover, in various studies, AT2R antagonists blocked the effects of MAS agonists and vice versa. Such cross-inhibition may indicate heterodimerization of these receptors. Therefore, this study investigated the molecular and functional interplay between MAS and the AT2R. Molecular interactions were assessed by fluorescence resonance energy transfer and by cross correlation spectroscopy in human embryonic kidney-293 cells transfected with vectors encoding fluorophore-tagged MAS or AT2R. Functional interaction of AT2R and MAS was studied in astrocytes with CX3C chemokine receptor-1 messenger RNA expression as readout. Coexpression of fluorophore-tagged AT2R and MAS resulted in a fluorescence resonance energy transfer efficiency of 10.8 ± 0.8%, indicating that AT2R and MAS are capable to form heterodimers. Heterodimerization was verified by competition experiments using untagged AT2R and MAS. Specificity of dimerization of AT2R and MAS was supported by lack of dimerization with the transient receptor potential cation channel, subfamily C-member 6. Dimerization of the AT2R was abolished when it was mutated at cysteine residue 35. AT2R and MAS stimulation with the respective agonists, Compound 21 or angiotensin-(1-7), significantly induced CX3C chemokine receptor-1 messenger RNA expression. Effects of each agonist were blocked by an AT2R antagonist (PD123319) and also by a MAS antagonist (A-779). Knockout of a single of these receptors made astrocytes unresponsive for both agonists. Our results suggest that MAS and the AT2R form heterodimers and that-at least in astrocytes-both receptors functionally depend on each other. © 2017 American Heart Association, Inc.

Action spectra and chromophores for lethal photosensitization of Candida albicans by DNA monoadducts formed by 8-methoxypsoralen and monofunctional furocoumarins

International Nuclear Information System (INIS)

Baydoun, S.; Gibbs, N.K.; Young, A.R.

1992-01-01

The red-shift furocoumarin action spectra, compared with their absorption spectra, has been investigated. An action spectrum for 8-methoxypsoralen (8-Mop) monoadduct formation in the yeast Candida albicans has been determined. The yeast cells were initially exposed to sublethal doses of monochromatic UV A at different wavelengths. Monoadduct formation was monitored by growth inhibition induced, after washing out any unbound 8-Mop, by re-irradiation with a constant second (non-lethal) dose of 330 nm radiation. A comparison between this action spectrum and the absorption spectrum of the dark complex of 8-Mop and DNA was made. In addition, the action spectra of monoadduct formation of five monofunctional compounds including a coumarin derivative have been determined. These action spectra were compared with their respective DNA dark complex absorption spectra. In general, the peaks of the furocoumarin DNA dark complexes show a red-shift when compared with the free furocoumarin molecule and the action spectra show peaks which correspond with the peaks of the dark complexes. Such data indicate that the DNA dark complex is the chromophore for growth inhibition in yeast rather than the free furocoumarin. The similarity of the 8-Mop monoadduct formation spectrum and 8-Mop action spectra suggests that spectral dependence for the photobiological effects (including the red-shift) is dependent on monoadduct formation rather than, as previously suggested by several authors, crosslink formation. The action spectrum for the coumarin derivative 4-methyl N-ethylpyrrolo (3,2-g) coumarin (PCNEt) correlated well with the free molecule absorption spectrum rather than DNA dark complex indicating that the free molecule is the chromophore. This was supported by studies which showed that PCNEt photosensitization is oxygen dependent. (author). 38 refs., 3 tabs., 7 figs

Detección y cuantificación del Potato mop-top virus (PMTV en Colombia mediante qRT-PCR

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Nevar García Bastidas

2013-04-01

Full Text Available El Potato mop-top virus (PMTV es uno de los virus re-emergentes en cultivos de papa en Colombia. Es transmitido por Spongospora subterranea, el agente causal de la sarna polvosa. La detección del PMTV presenta dificultades debido a su distribución irregular en las plantas, bajo título y movimiento sistémico como ARN desnudo. Con el fin de ampliar el rango de herramientas disponibles para detectar el PMTV en los programas de certificación de tubérculo-semilla, en este estudio se evaluó la prueba de RT-PCR en tiempo real (qRT-PCR en dos pasos: con los cebadores PMTV-1948F/PMTV-2017R y la sonda Taqman® PMTV-1970, dirigidos al gen CP-RT del ARN2 viral. Se construyó una curva estándar a partir de la transcripción in vitro de un fragmento de 1513 pb de este gen. Posteriormente, se evaluó la utilidad de la técnica a partir de tres tipos de muestras: plantas señuelo de Nicotiana benthamiana y Solanum phureja inoculadas con quistosoros de Sss, raíces de papa con síntomas de sarna polvosa del municipio de La Unión (Antioquia y tubérculos-semilla. Mediante qRT-PCR fue posible detectar el virus en 11 de las 20 muestras de raíz de plantas señuelo, mientras que 14 de las 15 muestras de raíces de papa resultaron positivas, estimándose una concentración entre 4.72 x 10(11 y 7.60 x 10(13 partículas virales/µl. Adicionalmente, en el ensayo de tubérculo-semilla se determinó la presencia del PMTV en una de las 16 muestras. Estos resultados indican la viabilidad de utilizar rutinariamente la técnica de qRT-PCR para la detección de PMTV en Colombia.

ANÁLISIS DE SISTEMAS DINÁMICOS CON pplane8.m (MATLAB® toolbox

Directory of Open Access Journals (Sweden)

Alejandro Regalado-Méndez

2013-01-01

Full Text Available En este trabajo se analizaron cuatro sistemas dinámicos (físico, químico, ecológico y económico, los cuales son representados por sistemas autónomos de dos ecuaciones diferenciales ordinarias. El objetivo principal es demostrar que pplane8.m es una herramienta computacional adecuada y eficiente. El análisis de los sistemas autónomos se llevó a cabo con base en la caracterización de sus puntos críticos de acuerdo a lo citado por Coughanowr & LeBlanc (2009 y con ayuda de pplane8.m (MATLAB® toolbox. Los principales resultados de este trabajo son que, pplane8.m (Polking, 2009 dibuja rápida y precisamente las trayectorias de todos los planos de fases, calcula con facilidad todos los puntos críticos y caracteriza correctamente cada uno de los puntos de equilibrio de los sistemas autónomos estudiados. Finalmente se puede decir que pplane8.m es una herramienta poderosa para ayudar en el proceso de enseñanza aprendizaje para estudiantes de un programa de ingeniería.

Benchmark experiment for the cross section of the 100Mo(p,2n)99mTc and 100Mo(p,pn)99Mo reactions

Science.gov (United States)

Takács, S.; Ditrói, F.; Aikawa, M.; Haba, H.; Otuka, N.

2016-05-01

As nuclear medicine community has shown an increasing interest in accelerator produced 99mTc radionuclide, the possible alternative direct production routes for producing 99mTc were investigated intensively. One of these accelerator production routes is based on the 100Mo(p,2n)99mTc reaction. The cross section of this nuclear reaction was studied by several laboratories earlier but the available data-sets are not in good agreement. For large scale accelerator production of 99mTc based on the 100Mo(p,2n)99mTc reaction, a well-defined excitation function is required to optimise the production process effectively. One of our recent publications pointed out that most of the available experimental excitation functions for the 100Mo(p,2n)99mTc reaction have the same general shape while their amplitudes are different. To confirm the proper amplitude of the excitation function, results of three independent experiments were presented (Takács et al., 2015). In this work we present results of a thick target count rate measurement of the Eγ = 140.5 keV gamma-line from molybdenum irradiated by Ep = 17.9 MeV proton beam, as an integral benchmark experiment, to prove the cross section data reported for the 100Mo(p,2n)99mTc and 100Mo(p,pn)99Mo reactions in Takács et al. (2015).

Technical description of the burn-up software system MOP

International Nuclear Information System (INIS)

Schutte, C.K.

1991-05-01

The burn-up software system MOP is a research tool primary intended to study the behaviour of fission products in any reactor composition. Input data are multi-group cross-sections and data concerning the nuclide chains. An option is available to calculate a fundamental mode neutron spectrum for the specified reactor composition. A separate program can test the consistency of the specified nuclide chains. Options are available to calculate time-dependent cross-sections of lumped fission products and to take account of the leakage of gaseous fission products from the reactor core. The system is written in FORTRAN77 for a CYBER computer, using the operating system NOS/BE. The report gives a detailed technical description of the applied algorithms and the flow and storage of data. Information is provided for adapting the system to other computer configurations. (author). 5 refs.; 11 figs

Alteration of lymphocyte functions by 8-methoxypsoralen and longwave ultraviolet radiation. I. Suppressive effects of PUVA on T-lymphocyte migration in vitro

International Nuclear Information System (INIS)

Okamoto, H.; Takigawa, M.; Horio, T.

1985-01-01

We investigated the influence of 8-methoxypsoralen (8-MOP) plus long-wave ultraviolet radiation (PUVA) on lymphocyte migration in vitro. Nylon wool-purified, mouse splenic T lymphocytes showed locomotive responses to casein, normal mouse serum (NMS), and zymosan-activated mouse serum (ZAS). Migratory responses to casein and NMS, and to ZAS were remarkably suppressed in lymphocytes exposed to 0.5 J/cm2 UVA plus 0.1 micrograms/ml 8-MOP and to 0.8 J/cm2 UVA plus 8-MOP, respectively. The PUVA treatment used in the present study had no effect on random movement and lymphocyte viability. T lymphocytes cultured in the absence of mitogenic agent for 24 h demonstrated a greater increase in their migration activity than noncultured cells, while lymphocytes cultured after 1.0 J/cm2 PUVA pretreatment remained low. These findings suggest that the therapeutic effect of PUVA on inflammatory skin disorders may be due in part to the suppression of lymphocyte migration

Thin film phase and local chirality of surface-bound MOP4 nanofibers

DEFF Research Database (Denmark)

Balzer, Frank; Röthel, Christian; Rubahn, Horst-Günter

2016-01-01

Vacuum deposition of the methoxy-functionalized p-quaterphenylene MOP4 on muscovite mica at elevated temperatures led to the formation of several ten micrometer long nanofibers. As shown by X-ray diffraction and polarized optical microscopy, the fibers are formed by lying molecules which grow...... diffraction (LEED) that had a crystal structure different from that of the fibers. Transfer of the sample from a vacuum to ambient conditions led to dewetting and the formation of clusters from the lying molecules. The samples aged via Ostwald ripening due to the presence of water vapor, which was monitored...

Solvation consequences of polymer PVP with biological buffers MES, MOPS, and MOPSO in aqueous solutions

International Nuclear Information System (INIS)

Gupta, Bhupender S.; Chen, Bo-Ren; Lee, Ming-Jer

2015-01-01

Highlights: • Densities and viscosities data for aqueous solutions with PVP and/or buffer. • The studied buffers include MES, MOPS, and MOPSO. • DFT was used to estimate the binding energies of the (PVP + buffer) complexes. • The viscosity data were correlated with the Jones–Dole equation. • The investigated buffers behave as Kosmotropies. - Abstract: Densities and viscosities were measured for the aqueous buffer (MES, MOPS, or MOPSO) solutions containing different concentrations of polyvinylpyrrolidone (PVP) (5, 10, 15, 20 and 30) mass% at temperatures from (298.15 to 318.15) K under atmospheric pressure. The DFT calculations were also performed and the binding energies of the possible (PVP + buffer) complexes were obtained. The experimental and computational results reveal the interactions of the PVP with the constituent compounds in the aqueous buffer solutions. Additionally we have explored the solvation behavior of the buffers by measuring the densities and the viscosities data of the aqueous buffer solutions from (0.0 to 1.0) mol · kg"−"1 at temperatures from (298.15 to 318.15) K. The viscosity results were correlated with the Jones–Dole equation. The correlated results confirmed that all the investigated buffers behave as Kosmotropes (structure makers).

Las indicaciones geográficas en el TLC firmado por Colombia y Perú con EUA frente al TLC con Chile.

OpenAIRE

Zarama Medina, Juan Andrés

2007-01-01

El propósito de este trabajo es hacer un análisis crítico del tratamiento que se ha dado a las Indicaciones Geográficas y mas específicamente a las Denominaciones de Origen en el Tratado de Libre Comercio que firmaron recientemente por Colombia y Perú, con los Estados Unidos (TLC), al que en adelante denominaremos TLC CAN, y compararlo con el TLC firmado con Chile (En adelante TLC CHILE). Para efectos de este trabajo, centraremos nuestra atención de manera específica en la tendencia de estos ...

Use of 8-methoxypsoralen and ultraviolet-A pretreated platelet concentrates to prevent alloimmunization against class I major histocompatibility antigens

International Nuclear Information System (INIS)

Grana, N.H.; Kao, K.J.

1991-01-01

The use of 8-methoxypsoralen (8-MOP) and UV-A irradiation to inactivate contaminating donor leukocytes in platelet concentrates and to prevent primary alloimmunization against donor class I major histocompatibility (MHC) antigens in mice was investigated. CBA/CaH-T6J mice with the H2k haplotype and BALB/cByJ mice with the H2d haplotype were used as donors and recipients, respectively. The mixed leukocyte reaction between these two strains of mice showed that treatment of spleen cells with 500 ng/mL 8-MOP and 5J/cm2 UV-A inhibited 99% of responder and 92% of stimulator function. There was no measurable loss of platelet aggregating activity after the treatment. After two weekly transfusions of platelets without any treatment, 93% of control mice (n = 15) developed anti-H2k antibody. In contrast, only 33% of mice (n = 15) receiving platelets treated with 8-MOP and UV-A became alloimmunized. After six weekly platelet transfusions, all mice became alloimmunized. Nevertheless, the mean titers of anti-H2k antibody in sera of the treated groups were significantly lower than the control groups. One hour posttransfusion recoveries of 51Cr-labeled donor platelets were also higher in mice transfused with the treated platelets. Thus, the pretreatment of platelet concentrates with 8-MOP and UV-A irradiation effectively reduced the alloantigenicity of class I MHC molecules. The implication of this finding in relation to the mechanism by which donor leukocytes allosensitize recipients is discussed

Integral parametrization of the Kinetics of Crosslink production in plasmid DNA as a function of 8-methoxypsoralen concentration

Energy Technology Data Exchange (ETDEWEB)

Vidania, R. de; Paramio, J. M.; Bauluz, C.

1986-07-01

In this paper we present results of crosslink production in pBR322 DNA along a wide range of 8-methoxypsoralen (8-MOP) concentration. Experimental data were obtained as DNA renaturation percentages, from the shift in hyperchromicity after a temperature-dependent denaturation-renaturation process. the experimental results showed a three-stage profile when represented as a function of the natural logarithms of 8-MOP concentration. an integral parametrization which allows a simultaneous fit of the three observed stages is presented here. the theoretical values of crosslink production determined from the fit are useful to asses the genotoxicity of psoralen-induced crosslinks in plasmid DNA. (Author) 24 refs.

Integral parametrization of the Kinetics of Crosslink production in plasmid DNA as a function of 8-methoxypsoralen concentration

International Nuclear Information System (INIS)

Vidania, R. de; Paramio, J. M.; Bauluz, C.

1986-01-01

In this paper we present results of crosslink production in pBR322 DNA along a wide range of 8-methoxypsoralen (8-MOP) concentration. Experimental data were obtained as DNA renaturation percentages, from the shift in hyperchromicity after a temperature-dependent denaturation-renaturation process. the experimental results showed a three-stage profile when represented as a function of the natural logarithms of 8-MOP concentration. an integral parametrization which allows a simultaneous fit of the three observed stages is presented here. the theoretical values of crosslink production determined from the fit are useful to asses the genotoxicity of psoralen-induced crosslinks in plasmid DNA. (Author) 24 refs

Production of Polyclonal Antiobies to a Recombinant Potato Mop-top Virus Non-structural Triple Gene Block Protein l

Czech Academy of Sciences Publication Activity Database

Čeřovská, Noemi; Filigarová, Marie; Pečenková, Tamara

2006-01-01

Roč. 154, - (2006), s. 422-427 ISSN 0931-1785 R&D Projects: GA ČR GA522/04/1329 Institutional research plan: CEZ:AV0Z50380511 Keywords : Potato mop-top virus * recombinant protein * triple gene block * polyclonal antibodies Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 0.817, year: 2006

Modulate function and effect of 60Co γ-rays on ConA-induced CD4+ and CD8+ subpopulations of lymphocytes

International Nuclear Information System (INIS)

Xu Yujie; Su Liaoyuan; Liu Keliang

1991-03-01

The monocyte-depleted peripheral blood mononuclear cells were separated into B, CD 4 + and CD 8 + subpopulations by a Panning technique with McAb CD 4 and CD 8 . The purity of the B, CD 4 + and CD 8 + subpopulations was 82.7%, 90.4% and 90.8% respectively, which was estimated by an indirect immunofluorescence technique. More than 92% of the three subpopulations were viable according to the trypan blue exclusion test. The radiosensitivities of ConA-induced CD 4 + and CD 8 + cells were assessed by 3 H-TdR incorporation. Experiment demonstrated that a part of ConA-induced CD 4 + and CD 8 + cells was radiosensitive but the rest of them was radioresistant. There was no significant difference between the sensitive part both in the ConA-induced CD 4 + and CD 8 + cells while there was great significant difference between the resistant one in the both cell lines. The modulate functions of ConA-induced CD 4 + and CD 8 + cells and the effect of 10 Gy 60 Co γ-rays on them were investigated by the technique of 3 H-TdR incorporation. It was demonstrated that the transformation of LPS-induced B lymphocytes was suppressed by the ConA-induced CD 4 + and CD 8 + cells. After irradiation, the suppressor activity of ConA-induced CD 4 + and CD 8 + cells didn't decrease. The suppressor activity of ConA-induced CD 8 + cells were enhanced by the ConA-induced CD 4 + cells significantly, and the suppressor activity of ConA-induced CD 4 + cells was also enhanced by the ConA-induced CD 8 + cells. After irradiation, the enhancement effects of the ConA-induced CD 4 + and CD 8 + cells disappeared

One-Pot Synthesis, X-Ray Diffraction and MAS NMR Spectroscopic Study of Gallosilicate Nitrate Cancrinite Na8[GaSiO4]6(NO34(H2O6

Directory of Open Access Journals (Sweden)

Ashok V. Borhade

2010-01-01

Full Text Available One-pot synthetic gallosilicate nitrate cancrinite (CAN framework topology have been synthesized under hydrothermal conditions at 100 °C. The synthesized product was characterized by, X-ray powder diffraction, IR, Raman and 29Si, 23Na MAS NMR spectroscopy, SEM and thermogravimetry. The crystal structure refinement of pure nitrate cancrinite has been carried out from X-ray data using Rietveld refinement method. Gallosilicate cancrinite Na8[GaSiO4]6(NO34(H2O6 crystalline hexagonal with space group P63 and a = 12.77981 Å (2, c = 5.20217 Å (1, (Rwp = 0.0696 Rp = 0.0527. The results by MAS NMR spectroscopy confirmed the alternating Si, Ga ordering of the gallosilicate framework for a Si/Ga ratio of 1.0. A distribution of the quadrupolar interaction of the sodium cations caused by the enclatherated water molecules and motional effects can be suggested from the 23Na MAS NMR. Thermogravimetric investigation shows the extent of nitrate entrapment, stability within the cancrinite cage and decomposition properties. SEM clearly shows the hexagonal needle shaped crystals of nitrate cancrinite.

UAV Robust Strategy Control Based on MAS

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Jian Han

2014-01-01

Full Text Available A novel multiagent system (MAS has been proposed to integrate individual UAV (unmanned aerial vehicle to form a UAV team which can accomplish complex missions with better efficiency and effect. The MAS based UAV team control is more able to conquer dynamic situations and enhance the performance of any single UAV. In this paper, the MAS proposed and established combines the reacting and thinking abilities to be an initiative and autonomous hybrid system which can solve missions involving coordinated flight and cooperative operation. The MAS uses BDI model to support its logical perception and to classify the different missions; then the missions will be allocated by utilizing auction mechanism after analyzing dynamic parameters. Prim potential algorithm, particle swarm algorithm, and reallocation mechanism are proposed to realize the rational decomposing and optimal allocation in order to reach the maximum profit. After simulation, the MAS has been proved to be able to promote the success ratio and raise the robustness, while realizing feasibility of coordinated flight and optimality of cooperative mission.

Exposure (mAs) optimisation of a multi-detector CT protocol for hepatic lesion detection: are thinner slices better?

International Nuclear Information System (INIS)

Dobeli, Karen L.; Lewis, Sarah J.; Meikle, Steven R.; Brennan, Patrick C.; Thiele, David L.

2014-01-01

The purpose of this work was to determine the exposure-optimised slice thickness for hepatic lesion detection with CT. A phantom containing spheres (diameter 9.5, 4.8 and 2.4mm) with CT density 10 HU below the background (50 HU) was scanned at 125, 100, 75 and 50 mAs. Data were reconstructed at 5-, 3- and 1-mm slice thicknesses. Noise, contrast-to-noise ratio (CNR), area under the curve (AUC) as calculated using receiver operating characteristic analysis and sensitivity representing lesion detection were calculated and compared. Compared with the 125 mAs/5mm slice thickness setting, significant reductions in AUC were found for 75 mAs (P<0.01) and 50 mAs (P<0.05) at 1- and 3-mm thicknesses, respectively; sensitivity for the 9.5-mm sphere was significantly reduced for 75 (P<0.05) and 50 mAs (P<0.01) at 1-mm thickness; sensitivity for the 4.8-mm sphere was significantly lower for 100, 75 and 50 mAs at all three slice thicknesses (P<0.05). The 2.4-mm sphere was rarely detected. At each slice thickness, noise at 100, 75 and 50 mAs exposures was approximately 10, 30 and 50% higher, respectively, than that at 125 mAs exposure. CNRs decreased in an irregular manner with reductions in exposure and slice thickness. This study demonstrated no advantage to using slices below 5mm thickness, and consequently thinner slices are not necessarily better.

Perspective of MAS in Power System via a Fuzzy Framework

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S. Razini

2017-03-01

Full Text Available Multi agent systems (MAS are popularly used in practice, however; a few studies have looked at MAS capabilities from the power engineering perspective. This paper presents the results of an investigation concerning the compatibility of MAS capabilities in different power engineering categories. Five MAS capabilities and seven power system categories are established. A framework for applying MAS in power engineering is developed. A fuzzy inference system is adopted to evaluate the paper proposed framework. Two approaches, namely simulation and real, are considered for different power categories. The paper shows that MAS capabilities are generally compatible with both approaches, although compatibility of MAS with real approach is more significant. The paper concludes that in the near future MAS is anticipated to be a key important tool in the development of intelligent systems and smart grids in power system. This paper contributes to thinking on perspective of MAS in power System.

Comportamiento agresivo y prosocial de escolares residentes en entornos con altos niveles de pobreza

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José William Martínez

Full Text Available Objetivos. Evaluar los niveles de agresividad directa e indirecta y prosocialidad en un grupo de escolares de colegios públicos ubicados en trece municipios de un departamento intermedio de Colombia. Materiales y métodos. Un total de 2785 niños y niñas con edades entre los tres y once años fueron evaluados con un instrumento validado para población colombiana, que mide agresividad y prosocialidad a través de la observación directa del maestro de escuela. Resultados. Los niños presentaron predominantemente comportamientos asociados con la agresividad directa (22,4% y las niñas a la agresividad indirecta (8,0%. Los comportamientos prosociales fueron mas comunes en las niñas (67,2% y en las edades de 10 y 11 años de edad (67,4 %. Conclusiones. El grado de presencia de comportamientos agresivos estaría relacionada con el contexto sociocultural en el que viven los niños y esta problemática puede ser detectada e intervenida por los maestros en la escuela.

Demodicidosis en pacientes con rosácea

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Edhizon Trejo Mucha

2007-01-01

Full Text Available Objetivo: Determinar la frecuencia de demodicidosis y sus características clínicas en pacientes con rosácea. Materiales y métodos: Estudio de casos y controles en 42 pacientes con rosácea y 42 controles para describir la presencia y densidad de D. folliculorum. El estudio se realizó en el Hospital Nacional Cayetano Heredia entre marzo y setiembre del 2004, utilizándose la técnica de Tello. Resultados: Demodex folliculorum fue encontrado en los 42 pacientes con rosácea (100% y en 13 (31,0% del grupo control, (p= 0,000. La exposición a gatos, la crianza de roedores y cerdos, la seborrea y el uso de corticoides tópicos fueron mas frecuentes en los pacientes con rosácea. Conclusiones: La presencia de Demodex folliculorum fue más frecuente en los pacientes con rosácea. (Rev Med Hered 2007;18:15-21.

An accelerated soil bait assay for the detection of potato mop top virus in agricultural soil.

Science.gov (United States)

Davey, Triona

2009-01-01

An accelerated soil bait test can be used to determine whether a field harbours virus-carrying Spongospora subterranea. S. subterranea is the causal agent of powdery scab and also the only vector of potato mop top virus (PMTV). Real-time RT-PCR can detect PMTV RNA in the roots of bait plants after 2 weeks of growth in viruliferous soil. This test may be used to assess the risk of planting potato crops in a particular field.

Use of 8-methoxypsoralen and long-wavelength ultraviolet radiation for decontamination of platelet concentrates

Science.gov (United States)

Corash, Laurence; Lin, Lily; Wiesehahn, Gary; Cimino, George

1992-06-01

Transmission of viral diseases through blood products remains a problem in transfusion medicine. A number of methods have been developed to inactivate viral pathogens in plasma and plasma fractions, including: dry heating, wet heating, solvent-detergent treatment, and immunoaffinity purification. While some of these methods successfully inactivate pathogenic viruses, inactivation may be incomplete or result in damage to labile plasma proteins and cells. We have developed a photochemical decontamination system (PCD) for platelet concentrates (PC) utilizing treatment with long wavelength ultraviolet radiation (UVA, 320 - 400 nm) and 8-methoxypsoralen (8-MOP). This system is capable of inactivating 25 - 30 logs/hr of bacteria E. coli or S. aureus, 6 logs/hr of bacteriophage fd, 0.9 log/hr of bacteriophage R17 and 1.1 logs/hr of feline leukemia virus (FeLV) in PC. Immediately following 6 hrs of PCD treatment, platelet integrity and function of PCD treated and control PC were equivalent. After overnight storage PCD treated and control PC platelet properties were equal, but there was a slight reduction in TXB-2 production of PCD treated PC compared to controls. Following PCD treatment, PC were stored for 48 to 96 hrs. Platelet counts, morphology scores, extracellular LDH levels, aggregation response, dense body (db) content, and alpha granule ((alpha) g) content of PCD treated and control PC were comparable. We assessed the ability of the PCD technique to inactivate intracellular and extracellular virus, quantified the degree of DNA adduct formation in contaminating lymphocytes, and measured the inhibition of polymerase chain reaction (PCR) mediated amplification of intracellular DNA. High titers of cell-free murine cytomegalovirus added to human platelet concentrates (final concentration 106) were inactivated by PCD within 30 min. Cat renal fibroblasts infected at high levels with feline rhinotracheitis virus (FeRTV) were seeded into PC followed by PCD treatment with

Hierarchical MAS based control strategy for microgrid

Energy Technology Data Exchange (ETDEWEB)

Xiao, Z.; Li, T.; Huang, M.; Shi, J.; Yang, J.; Yu, J. [School of Information Science and Engineering, Yunnan University, Kunming 650091 (China); Xiao, Z. [School of Electrical and Electronic Engineering, Nanyang Technological University, Western Catchment Area, 639798 (Singapore); Wu, W. [Communication Branch of Yunnan Power Grid Corporation, Kunming, Yunnan 650217 (China)

2010-09-15

Microgrids have become a hot topic driven by the dual pressures of environmental protection concerns and the energy crisis. In this paper, a challenge for the distributed control of a modern electric grid incorporating clusters of residential microgrids is elaborated and a hierarchical multi-agent system (MAS) is proposed as a solution. The issues of how to realize the hierarchical MAS and how to improve coordination and control strategies are discussed. Based on MATLAB and ZEUS platforms, bilateral switching between grid-connected mode and island mode is performed under control of the proposed MAS to enhance and support its effectiveness. (authors)

MAS NMR of HIV-1 protein assemblies

Science.gov (United States)

Suiter, Christopher L.; Quinn, Caitlin M.; Lu, Manman; Hou, Guangjin; Zhang, Huilan; Polenova, Tatyana

2015-04-01

The negative global impact of the AIDS pandemic is well known. In this perspective article, the utility of magic angle spinning (MAS) NMR spectroscopy to answer pressing questions related to the structure and dynamics of HIV-1 protein assemblies is examined. In recent years, MAS NMR has undergone major technological developments enabling studies of large viral assemblies. We discuss some of these evolving methods and technologies and provide a perspective on the current state of MAS NMR as applied to the investigations into structure and dynamics of HIV-1 assemblies of CA capsid protein and of Gag maturation intermediates.

Experimental Observation of Three-Component New Fermions in Topological Semimetal MoP

Science.gov (United States)

Lv, B. Q.; Feng, Z.-L.; Xu, Q.-N.; Ma, J.-Z.; Kong, L.-Y.; Richard, Pierre; Huang, Y.-B.; Strocov, V. N.; Fang, C.; Weng, H.-M.; Shi, Y.-G.; Qian, Tian; Ding, Hong; Paul Scherrer Institute, Swiss Light Source, CH-5232 Villigen PSI, Switzerland Team; Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics Team; University of Chinese Academy of Sciences, Beijing 100190, China Team; Collaborative Innovation Center of Quantum Matter, Beijing, China Collaboration; Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China Team

Condensed matter systems can host quasiparticle excitations that are analogues to elementary particles such as Majorana, Weyl, and Dirac fermions. Recent advances in band theory have expanded the classification of fermions in crystals, and revealed crystal symmetry-protected electron excitations that have no high-energy counterparts. Here, using angle-resolved photoemission spectroscopy, we demonstrate the existence of a triply degenerate point in the electronic structure of MoP crystal, where the quasiparticle excitations are beyond the Majorana-Weyl-Dirac classification. Furthermore, we observe pairs of Weyl points in the bulk electronic structure coexisting with the new fermions, thus introducing a platform for studying the interplay between different types of fermions. We thank Binbin Fu, Nan Xu, and Xin Gao for the assistance in the ARPES experiments.

Estudio de 100 casos de hemorragia uterina con legrado-biopsia

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Germán Jordán

1953-01-01

Full Text Available El cáncer del cuerpo uterino se presenta con mayor frecuencia en la sexta década de la vida, y en relación con el cáncer del cuello uterino en una proporción de un caso por ocho, respectivamente. Su evolución y sintomatología, mucho más benignas y lentas que las del cáncer del cuello, hacen mas fácil su tratamiento y favorable su pronostico.

Inhibitory potency of 8-methoxypsoralen on cytochrome P450 2A6 (CYP2A6 allelic variants CYP2A6 15, CYP2A6 16, CYP2A6 21 and CYP2A6 22: differential susceptibility due to different sequence locations of the mutations.

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Kai Hung Tiong

Full Text Available Human cytochrome P450 2A6 (CYP2A6 is a highly polymorphic isoform of CYP2A subfamily. Our previous kinetic study on four CYP2A6 allelic variants (CYP2A6 15, CYP2A6 16, CYP2A6 21 and CYP2A6 22 have unveiled the functional significance of sequence mutations in these variants on coumarin 7-hydroxylation activity. In the present study, we further explored the ability of a typical CYP2A6 inhibitor, 8-methoxypsoralen (8-MOP, in inhibition of these alleles and we hypothesized that translational mutations in these variants are likely to give impact on 8-MOP inhibitory potency. The CYP2A6 variant and the wild type proteins were subjected to 8-MOP inhibition to yield IC50 values. In general, a similar trend of change in the IC50 and Km values was noted among the four mutants towards coumarin oxidation. With the exception of CYP2A6 16, differences in IC50 values were highly significant which implied compromised interaction of the mutants with 8-MOP. Molecular models of CYP2A6 were subsequently constructed and ligand-docking experiments were performed to rationalize experimental data. Our docking study has shown that mutations have induced enlargement of the active site volume in all mutants with the exception of CYP2A6 16. Furthermore, loss of hydrogen bond between 8-MOP and active site residue Asn297 was evidenced in all mutants. Our data indicate that the structural changes elicited by the sequence mutations could affect 8-MOP binding to yield differential enzymatic activities in the mutant CYP2A6 proteins.

What drives cross-border M&As in commercial banking?

NARCIS (Netherlands)

Galamhussen, Mohamed; Hennart, Jean-Francois; Pinheiro, Carlos Manuel

2016-01-01

Using a gravity model, we analyze the determinants of the probability that commercial banks in 89 acquiring countries and 118 target countries will undertake M&As over a 30-year period (1981–2010) and of the value of these M&As. We find that the value of cross-border M&As increases with the size of

Las indicaciones geográficas en el TLC firmado por Colombia y Perú con EUA frente al TLC con Chile.

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Juan Andrés Zarama Medina

2007-06-01

Full Text Available El propósito de este trabajo es hacer un análisis crítico del tratamiento que se ha dado a las Indicaciones Geográficas y mas específicamente a las Denominaciones de Origen en el Tratado de Libre Comercio que firmaron recientemente por Colombia y Perú, con los Estados Unidos (TLC, al que en adelante denominaremos TLC CAN, y compararlo con el TLC firmado con Chile (En adelante TLC CHILE. Para efectos de este trabajo, centraremos nuestra atención de manera específica en la tendencia de estos tratados a tratar las indicaciones geográficas y en especial las denominaciones de origen, como marcas colectivas y de certificación o garantía.

Silla multipropósito con medios auxiliares

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René Ramón Toledo González

2009-06-01

Full Text Available Nuestro país no cuenta con la cantidad de sillones de rueda necesario para suplir las necesites de la población con diferentes tipos de discapacidades, en nuestro municipio existen muchos discapacitados que no pueden trasladarse a los servicios de rehabilitación, ni cuenta con medio de traslado en sus propios hogares lo que entorpecen su evolución y los hace mas dependientes; otro grupo de pacientes poseen sillón de ruedas útil para su traslado pero no para realizar  otras  actividades  de  la  vida  diaria  y  tienen  que  valerse  de  otras personas para realizar las mismas. La silla que hemos creado se hace con recursos y materias primas propias de nuestro país sin tener necesidad de compras de accesorios en el exterior; lo que nos permite a la vez que se resuelva un gran problema económico al país.

HPLC analysis of 4',5'-monoadduct formation in calf thymus DNA and synthetic polynucleotides treated with UVA and 8-methoxypsoralen

International Nuclear Information System (INIS)

Gasparro, F.P.; Bagel, J.; Edelson, R.L.

1985-01-01

8-methoxypsoralen monoadduct formation in calf thymus DNA irradiated with subbands of ultraviolet A light has been quantitated by HPLC analysis of the enzymatic hydrolysates of the DNA. Normalization of the yield of monoadducts for the variation in source output and the absorptivity of 8-MOP at each of the irradiating wavelengths showed that the 4',5'-furan monoadduct was the principal photoproduct and the efficiency of its formation was independent of irradiating wavelength. Synthetic polynucleotides irradiated with ultraviolet A light demonstrated a base composition and sequence dependence for 8-MOP photoreactivity: (poly(dAdT.dAdT)>poly(dA.dT)>poly(dGdC.dGdC) in both the B and Z forms>poly(dT). (author)

Photoreaction of 8-methoxypsoralen with thymidine

International Nuclear Information System (INIS)

Shim, S.C.; Kim, Y.Z.

1983-01-01

The photoreaction of 8-methoxypsoralen (8-MOP) with thymidine in solid film state yielded two 4',5'-monoadducts (a pair of diastereomers) and three 3,4-monoadducts. The stereochemistry of two 4',5'monoadducts was found to be cis-syn and trans-syn and one 3,4-monoadduct was cis-anti. In addition to these monoadducts, 3,4-, 4',5-biadducts were also formed during the reaction, but the isolation of each isomer of these adducts was not successful; however, the formation of these biadducts was confirmed by UV, IR, TLC and photosplitting experiments. (author)

Prophage induction, mutagenesis, and cell survival of Ames' mutagen tester strains after 8-methoxypsoralen plus ultraviolet light-A

Energy Technology Data Exchange (ETDEWEB)

Wheeler, L.A.; DeMeo, M. (California Univ., Los Angeles (USA)); Lowe, N. (Combined UCLA-WADSWORTH Dermatology Program, Los Angeles, CA (USA))

1983-10-01

8-methoxypsoralen (8-MOP) is not detected as a mutagen in the standard Ames test either in the presence or absence of S9-mix and/or ultraviolet light-A (320-400 nm). The Ames strains have been shown to harbor bacteriophages that are inducible by carcinogens and mutagens. Psoralen plus UVA (PUVA) was found to be a potent prophage inducing treatment. Induction was observed in TA1535, TA1538, TA98, TA100, TA1978 and TA1975 with 8-MOP and UVA. PUVA is a potent bactericidal treatment at concentrations of 8-MOP above 0.5 ..mu..g/ml and 2.5 kJ/m/sup 2/ in tester strains TA1535, TA1538, TA98 and TA100. PUVA is known to be bactericidal, but the cytotoxicity observed in the present study was unique in that the frameshift tester strains (TA1538 and TA98) were more sensitive to the lethal effects of PUVA than the base pair tester strains (TA1535 and TA100). The differential cytotoxicity in such closely related strains led to the examination of some of the strains from which the Ames strains were derived. It is postulated that TA1535 retains a DNA repair function that is lost by TA1538 during the selection for uvrB deficient strains.

Evaluación del optimismo disposicional en pacientes en hemodiálisis y su relación con las complicaciones

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Isabel Luque Cantarero

2014-12-01

Full Text Available Introducción: El optimismo parece tener una influencia sobre la resistencia a la enfermedad y de la mejora de la salud en pacientes con problemas cardíacos, respiratorios y oncológicos. Sin embargo, son escasos los estudios en pacientes en con enfermedad crónica renal en hemodiálisis; de ahí el interés de nuestro estudio. Objetivo: El objetivo de este estudio fue analizar la relación entre el grado de optimismo disposicional con las complicaciones y la calidad de vida percibida en un grupo de pacientes de hemodiálisis. Pacientes y Métodos: Se estudiaron 78 pacientes en HD, del servicio de Nefrología de Córdoba. Se realizó un estudio observacional analítico. Se evaluaron variables demográficas, tiempo en diálisis, índice de comorbilidad de Charlson, centro de diálisis, acceso vascular, optimismo disposicional mediante el LOT-R (a mas puntuación más optimismo, calidad de vida relacionada con la salud mediante láminas COOP-WONCA (a mas puntuación peor calidad de vida percibida y número de ingresos en el año anterior. Resultados: La edad media fue 64.8±17.1 años. El 38.5% eran mujeres y el 61.5% hombres. La mediana del número de ingresos en el último año fue de 1 (rango: 0-10. La mediana del índice de comorbilidad fue 7 (rango 0-12. La media del LOT-R fue 20.76±4.8 y la mediana 21 (rango: 8-29. Se estableció la mediana del LOT-R, como punto de corte para clasificar a los pacientes como optimistas (>21 de mediana y pesimistas (<21. Al comparar ambos grupos (optimistas frente a pesimistas se encontraron diferencias significativas para el COOP-WONCA (19.8±5.6 frente a 24.5±6.6, p<0.002. Sin embargo no se encontraron diferencias para el número de ingresos, ni para el índice de comorbilidad, entre ambos grupos. Conclusiones: No se encontró relación entre optimismo disposicional y número de ingresos, ni comorbilidad asociada. Sin embargo, los más optimistas tienen mayor de calidad de vida percibida relacionada con

CP/MAS 13C NMR characterization of the isomeric states and intermolecular packing in tris(8-hydroxyquinoline) aluminum(III) (Alq3).

Science.gov (United States)

Kaji, Hironori; Kusaka, Yasunari; Onoyama, Goro; Horii, Fumitaka

2006-04-05

The isomeric states and intermolecular packing of tris(8-hydroxyquinoline) aluminum(III) (Alq(3)) in the alpha-, gamma-, and delta-crystalline forms and in the amorphous state, which are important for understanding the light-emitting and electron-transport properties, have been analyzed by CP/MAS (13)C NMR. This simple NMR experiment shows that the isomeric state of alpha- and amorphous Alq(3) is meridional, whereas that of gamma- and delta-Alq(3) is facial. In the amorphous Alq(3), the inclusion of facial isomers has been under debate. Our experiments show that meridional isomers are dominant in the amorphous Alq(3), although the existence of facial isomers cannot be completely denied. The local structure of amorphous Alq(3) is similar to that of alpha-Alq(3) and is significantly different from those of gamma- and delta-Alq(3). Among these Alq(3) samples, the effect of intermolecular interaction is not found only for gamma-Alq(3). This finding can explain the good solvent solubility of gamma-Alq(3), compared with the other crystalline forms. It is also shown that the structures are locally disordered not only for amorphous Alq(3) but also for alpha-Alq(3), although clear X-ray diffraction peaks are observed for alpha-Alq(3). In contrast, the local structures of gamma- and delta-Alq(3) are well defined. A clear relation is found between the spectral patterns of CP/MAS (13)C NMR and the fluorescence wavelengths; the samples, which consist of facial isomers, show blue-shifted fluorescence compared with those of meridionals.

Hydronephrosis alters cardiac ACE2 and Mas receptor expression in mice.

Science.gov (United States)

Zhang, Yanling; Ma, Lulu; Wu, Junyan; Chen, Tingting

2015-06-01

Hydronephrosis is characterized by substantial loss of tubules and affects renin secretion in the kidney. However, whether alterations of angiotensin-converting enzyme (ACE), ACE2 and Mas receptor in the heart are observed in hydronephrosis is unknown. Thus, we assessed these components in hydronephrotic mice treated with AT1 receptor blockade and ACE inhibitor. Hydronephrosis was induced by left ureteral ligation in Balb/C mice except sham-operated animals. The levels of cardiac ACE, ACE2 and Mas receptor were measured after treatment of losartan or enalapril. Hydronephrosis led to an increase of ACE level and a decrease of ACE2 and Mas receptor in the heart. Losartan decreased cardiac ACE level, but ACE2 and Mas receptor levels significantly increased in hydronephrotic mice (p Hydronephrosis increased cardiac ACE and suppressed ACE2 and Mas receptor levels. AT1 blockade caused sustained activation of cardiac ACE2 and Mas receptor, but ACE inhibitor had the limitation of such activation of Mas receptor in hydronephrotic animals. © The Author(s) 2015.

Spectroscopic and vibrational analysis of the methoxypsoralen system: A comparative experimental and theoretical study

Science.gov (United States)

Liu, Y.; Yuan, H.; Vo-Dinh, T.

2013-03-01

Raman spectra measurements and density functional theory (DFT) calculations were performed to investigate three psoralens: 5-amino-8-methoxypsoralen (5-A-8-MOP), 5-methoxypsoralen (5-MOP) and 8-methoxypsoralen (8-MOP) with the aim of differentiating these similar bioactive molecules. The Raman spectra were recorded in the region 300-3500 cm-1. All three psoralens were found to have similar Raman spectrum in the region 1500-1650 cm-1. 5-A-8-MOP can be easily differentiated from 5-MOP or 8-MOP based on the Raman spectrum. The Raman spectrum differences at 651 and 795 cm-1 can be used to identify 5-MOP from 8-MOP. The theoretically computed vibrational frequencies and relative peak intensities were compared with experimental data. DFT calculations using the B3LYP method and 6-311++G(d,p) basis set were found to yield results that are very comparable to experimental Raman spectra. Detailed vibrational assignments were performed with DFT calculations and the potential energy distribution (PED) obtained from the Vibrational Energy Distribution Analysis (VEDA) program.

Angiotensin-(1-7)/Mas axis modulates fear memory and extinction in mice.

Science.gov (United States)

Lazaroni, Thiago Luiz do Nascimento; Bastos, Cristiane Perácio; Moraes, Márcio Flávio Dutra; Santos, Robson Souza; Pereira, Grace Schenatto

2016-01-01

Inappropriate defense-alerting reaction to fear is a common feature of neuropsychiatric diseases. Therefore, impairments in brain circuits, as well as in molecular pathways underlying the neurovegetative adjustments to fear may play an essential role on developing neuropsychiatric disorders. Here we tested the hypothesis that interfering with angiotensin-(1-7) [Ang-(1-7)]/Mas receptor axis homeostasis, which appears to be essential to arterial pressure control, would affect fear memory and extinction. Mas knockout (MasKO) mice, in FVB/N background, showed normal cued fear memory and extinction, but increased freezing in response to context. Next, as FVB/N has poor performance in contextual fear memory, we tested MasKO in mixed 129xC57BL/6 background. MasKO mice behaved similarly to wild-type (WT), but memory extinction was slower in contextual fear conditioning to a weak protocol (1CS/US). In addition, delayed extinction in MasKO mice was even more pronounced after a stronger protocol (3CS/US). We showed previously that Angiotensin II receptor AT1 antagonist, losantan, rescued object recognition memory deficit in MasKO mice. Here, losartan was also effective. Memory extinction was accelerated in MasKO mice after treatment with losartan. In conclusion, we showed for the first time that Ang-(1-7)/Mas axis may modulate fear memory extinction. Furthermore, we suggest MasKO mice as an animal model to study post-traumatic stress disorder (PTSD). Copyright © 2015 Elsevier Inc. All rights reserved.

ESTUDIO COMPARATIVO DEL EFECTO DE CRANEO-ACUPUNTURA VS ACUPUNTURA CORPORAL, EN PACIENTES CON SECUELAS DE ENFERMEDAD VASCULAR CEREBRAL EN EL HOSPITAL REGIONAL DEL INSTITUTO DE SEGURIDAD SOCIAL AL SERVICIO DE LOS TRABAJADORES DEL ESTADO DE PUEBLA

OpenAIRE

MENDEZ MENDEZ, NAZARIO CELSO

2011-01-01

ESTUDIO COMPARATIVO DEL EFECTO DE LA CRANEOACUPUNTURA VS ACUPUNTURA CORPORAL, EN PACIENTES CON SECUELAS DE ENFERMEDAD VASCULAR CEREBRAL EN EL HOSPITAL REGIONAL DEL INSTITUTO DE SEGURIDAD SOCIAL AL SERVICIO DE LOS TRABAJADORES DEL ESTADO DE PUEBLA. LAS SECUELAS DE EVC SON UN PROBLEMA DE SALUD PUBLICA, CON MAYOR FRECUENCIA DE LA ISQUEMIA 81.25 POR CIENTO POR CIENTO Y EN SEGUNDO LUGAR LA HEMORRÁGICA CON EL 18.75 POR CIENTO, EL SEXO FEMENINO ES LA MAS FRECUENTE Y LA EDAD MAS AFECTADA ES DE LO...

Increased vascular sympathetic modulation in mice with Mas receptor deficiency

Science.gov (United States)

Rabello Casali, Karina; Ravizzoni Dartora, Daniela; Moura, Marina; Bertagnolli, Mariane; Bader, Michael; Haibara, Andrea; Alenina, Natalia; Irigoyen, Maria Claudia; Santos, Robson A

2016-01-01

Introduction: The angiotensin-converting enzyme 2 (ACE2)/angiotensin (Ang)-(1–7)/Mas axis could modulate the heart rate (HR) and blood pressure variabilities (BPV) which are important predictors of cardiovascular risk and provide information about the autonomic modulation of the cardiovascular system. Therefore we investigated the effect of Mas deficiency on autonomic modulation in wild type and Mas-knockout (KO) mice. Methods: Blood pressure was recorded at high sample rate (4000 Hz). Stationary sequences of 200–250 beats were randomly chosen. Frequency domain analysis of HR and BPV was performed with an autoregressive algorithm on the pulse interval sequences and on respective systolic sequences. Results: The KO group presented an increase of systolic arterial pressure (SAP; 127.26±11.20 vs 135.07±6.98 mmHg), BPV (3.54±1.54 vs 5.87±2.12 mmHg2), and low-frequency component of systolic BPV (0.12±0.11 vs 0.47±0.34 mmHg2). Conclusions: The deletion of Mas receptor is associated with an increase of SAP and with an increased BPV, indicating alterations in autonomic control. Increase of sympathetic vascular modulation in absence of Mas evidences the important role of Ang-(1–7)/Mas on cardiovascular regulation. Moreover, the absence of significant changes in HR and HRV can indicate an adaptation of autonomic cardiac balance. Our results suggest that the Ang-(1–7)/Mas axis seems more important in autonomic modulation of arterial pressure than HR. PMID:27080540

31P Solid-state MAS NMR spectra

International Nuclear Information System (INIS)

Grobet, P.J.; Geerts, H.; Martens, J.A.; Jacobs, P.A.

1989-01-01

The structures of the silicoaluminiophosphates MCM-1 and MCM9 were characterized by 27 Al and 31 P MAS NMR. The structural identity of MCM-1 and its silicon-free homologue AlPO 4 -H 3 is demonstrated. The presence of a structural mixture in MCM-9 is confirmed. 31 P MAS NMR spectra of MCM-9 could be interpreted as a superposition of spectra of VPI-5, AlPO 4 -H 3 and SAPO-11 phases. (author). 12 refs.; 3 figs.; 1 tab

Photobinding of 3H 8-methoxypsoralen to monkey intraocular tissues

International Nuclear Information System (INIS)

Lerman, S.; Megaw, J.; Gardner, K.; Takei, Y.; Franks, Y.; Gammon, A.

1984-01-01

Young (less than 1 year) and old (greater than 15 years) Rhesus monkeys were utilized in this study in order to determine whether ultraviolet (UV) radiation at ambient levels induces psoralen photobinding in primate eyes (in particular the lens and retina). Unilateral aphakia or pseudophakia was induced surgically and the eyes were allowed to heal. The animals then were given a single intraperitoneal injection of 3 H 8-methoxypsoralen (8-MOP) and immediately exposed to BLB lights (of measured radiation intensity at the corneal surface). The animals were killed at varying time periods (2-6 weeks), and the eyes were removed immediately. One-half of each cornea and lens was frozen for subsequent optical spectroscopy and the remaining ocular tissues were fixed for histopathologic studies and autoradiography. These data demonstrate that low level UV radiation (less than 0.4 mW/cm2) can cause 8-MOP photobinding to lens proteins and DNA and to aphakic, pseudophakic, and young phakic primate retinas. The older phakic primate lens serves as a protective UV filter and prevents psoralen photobinding within the retina. These data suggest that older aphakes and pseudophakes may require UV radiation protection to prevent direct as well as photosensitized retinal photodamage

CONFIGURACIÓN DE UNA RED DE NUEVA GENERACIÓN PARA CONECTIVIDAD CON INTERNET RESPALDADO POR UN SERVICIO DNS CON SOPORTE PARA IPV4 E IPV6.

Directory of Open Access Journals (Sweden)

Carlos Andrés Martínez

2012-05-01

Full Text Available Se presentan las características mas representativas de la implementación de la isla ipv6 del centro de computación de alto desempeño CECAD, realizando pruebas de conexión y desempeño en el tráfico interno con las subredes de la Universidad Distrital y posteriormente con su conexión a Internet a través del protocolo NAT-PT secundado por un servidor de nombres de domino recursivo como base de conectividad y soporte sobre estructuras Ipv4 e Ipv6 nativas.

Natural attenuation in contaminated soils with hydrocarbons; Atenuacion natural en suelos contaminados con hidrocarburos

Energy Technology Data Exchange (ETDEWEB)

Corona Ramirez, L; Iturbide Arguelles, R [Facultad de Ingenieria, UNAM, Mexico, D.F. (Mexico)

2005-06-01

A contaminated soil experiment was performed using simples from a refinery, containing oil derivative hydrocarbons, specifically those with high concentrations of polyaromathic hydrocarbons (PAH). The testing consisted in 7 pans with 7 kg of soil, the preparation of 6 pans under specific conditions and one as a blank, the conditions were: water content (15 y 30%), addition a non-ionic surfactant. The process consisted in the daily aeration and water control of the samples. The PAH were analyzed: anthracene, benzo(a) pyrene, chrysene, phenanthrene and naphthalene. The results after 8 weeks showed a gradual degradation of PAH, indicating a better removal obtained when the water content was 30% with nutrients addition. [Spanish] Se realizo un experimento con suelo contaminado proveniente de una refineria, el cual contaba con hidrocarburos derivados de petroleo, especificamente con concentraciones elevadas de hidrocarburos poliaromaticos (HAP). El estudio consistio en preparar 7 cajones con 7 kg de suelo, cada uno con las siguientes condiciones: S1suelo contaminado con hidrocarburos y 15% de contenido de agua. S2 suelo contaminado con hidrocarburo y adicion de Nitrogeno y Fosforo (N y P) con 15% de contenido de agua. S3 suelo contaminado con hidrocarburo y adicion de N y P mas un surfactante no ionico, Emulgin W600, con 15% de contenido de agua. S4 igual a S1 pero con 30% de contenido de agua. S5 igual a S2, con 30% de contenido de agua. S6 igual S3 con 30% de contenido de agua. S7 suelo contaminado testigo, sin control de humedad y sin aireacion. La experimentacion consistio en airear el suelo diariamente y controlar el contenido de agua de manera que este fuera constante. Los resultados, indican que la mejor remocion se obtuvo para el contenido de agua de 30%, con adicion de nutrientes y surfactante. Los compuestos con mayor eficiencia de remocion para todas las opciones son naftaleno y antraceno. Por lo tanto, de acuerdo con los resultados, los compuestos

Pharmacokinetic and biopharmaceutic aspects of some psoralen derivatives used in dermatology

International Nuclear Information System (INIS)

Stolk, L.M.L.

1982-01-01

In the present thesis the pharmacokinetic and biopharmaceutic properties of some psoralen derivatives, that are used in photochemotherapy of dermatological diseases like vitiligo and psoriasis, are studied. Photochemotherapy is a combination of oral administration of one of the psoralen derivatives, 8-methoxypsoralen (8-MOP), 5-methoxypsoralen (5-MOP) or 4, 5', 8-trimethylpsoralen (TMP), and irradiation with long wave ultraviolet light, U.V.-A (320-400 nm), two hours later. This treatment is commonly called PUVA (Psoralen-UV-A). The purpose of the investigation was to develop an 8-MOP dosage form with a fast and reproducible absorption. Various dosage forms of 8-MOP were administered to volunteers and patients and 8-MOP concentrations in body fluids determined. Also the pharmacokinetic properties of 5-MOP and TMP were investigated in a pilot study. (Auth.)

ERP sistēmas ieviešana

OpenAIRE

Proskurins, Aleksandrs

2008-01-01

Šajā darbā tika apskatīta informācijas sistēmu klasifikācija, uzņēmuma resursu plānošanas sistēmas (ERP) definīcija un tās vieta IS klasifikācijā. Tika apskatīti ERP sistēmu ieviešanas teorētiskie aspekti, izstrādes un pielāgošanas specifika, kā arī tika izanalizēti vairāki ERP sistēmas ieviešanas projekti Latvijas uzņēmumos.

Study on MAs transmutation of accelerator-driven system sodium-cooled fast reactor loaded with metallic fuel

International Nuclear Information System (INIS)

Han Song; Yang Yongwei

2007-01-01

Through the analysis of the effect of heavy metal actinides on the effective multiplication constant (k eff ) of the core in accelerator-driven system (ADS) sodium-cooled fast reactor loaded with metallic fuel, we gave the method for determining fuel components. the characteristics of minor actinides (MAs) transmutation was analyzed in detail. 3D burn-up code COUPLE, which couples MCNP4c3 and ORIGEN2, was applied to the neutron simulation and burn up calculation. The results of optimized scheme shows that adjusting the proportion of 239 Pu and maintaining the value during the burn-up cycle is an efficient method of designing k eff and keeping stable during the burn-up cycle. Spallation neutrons lead to the neutron spectrum harder at inner core than that at outer core. It is in favor of improving MA's fission cross sections and the capture-to-fission ratio. The total MAs transmutation support ratio 8.3 achieves excellent transmutation effect. For higher flux at inner core leads to obvious differences on transmutation efficiency,only disposing MAs at inner core is in favor of decreasing the loading mass and improving MAs transmutation effect. (authors)

Efficient bacterial expression of recombinant potato mop-top virus non-structural triple gene block protein 1 modified by progressive deletion of its N-terminus

Czech Academy of Sciences Publication Activity Database

Pečenková, Tamara; Filigarová, Marie; Čeřovská, Noemi

2005-01-01

Roč. 41, - (2005), s. 128-135 ISSN 1046-5928 R&D Projects: GA ČR GA522/04/1329 Institutional research plan: CEZ:AV0Z50380511 Keywords : Protein expression * Potato mop-top virus * Triple gene block Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 1.553, year: 2005

Uso del FitoMas-E® como atenuante del estrés salino (NaCl durante la emergencia y crecimiento inicial de Ocimum basilicum L.

Directory of Open Access Journals (Sweden)

D. Batista-Sánchez

2015-01-01

Full Text Available El uso de bioestimulantes vegetales estimula la emergencia y el crecimiento vegetal debido a que están compuestos por sustancias naturales como carbohidratos, péptidos de bajo peso molecular y aminoácidos, activadores de las funciones fisiológicas de las plantas, por lo que su aplicación permite un mejor aprovechamiento de los nutrientes y representa una opción para enfrentar problemas de estrés abiótico por salinidad. El objetivo de este estudio fue determinar el efecto del bioestimulante FitoMas-E® derivado de la caña de azúcar como atenuante de la salinidad en la emergencia y el crecimiento de plántulas de variedades de albahaca (Ocimum basilicum L. con respuesta diferencial al estrés por salinidad. Tres variedades de albahaca: Napoletano, Emily y Nufar se sometieron a cuatro concentraciones de NaCl (0, 50, 100 y 150 mM y cuatro dosis de FitoMas-E® (0, 0.5, 1.0 y 1.5 mL L-1 en un diseño completamente al azar con arreglo factorial con cuatro repeticiones. El trabajo se desarrolló en una estructura de malla sombra y las variables que se midieron fueron: porcentaje y tasa de emergencia, longitud de radícula, altura de la plántula, biomasa fresca y seca de radícula y de parte aérea. Los resultados evidenciaron que en condiciones de estrés salino (NaCl de moderado a severo, las variables disminuyeron significativamente. Largo de raíz, altura de planta y biomasa seca de raíz en 150 mM de NaCl fueron las más afectadas. Se observó que cuando se aplicó FitoMas-E® las plantas incrementaron significativamente sus valores en las variables, largo de raíz 32% y altura de planta 41%, lo que revela el efecto estimulante del FitoMas-E®, siendo 0.5 mL L-1 la dosis estimulante para la variedad Napoletano y 1.0 mL L-1 para la variedad Emily, aún y cuando se encontraban en condiciones de estrés salino hasta 100 mM de NaCl. Para la concentración de 150 mM se evidenció una afectación extrema para las variedades Emily y Nufar.

Molecular and biological characterization of Potato mop-top virus (PMTV, Pomovirus) isolates from potato-growing regions in Colombia

DEFF Research Database (Denmark)

Gil, José; Adams, Ian; Boonham, Neil

2016-01-01

Potato mop-top virus (PMTV) causes necrotic flecks inside and on tubers in temperate countries. In South America, these symptoms have not been observed, although the presence of the virus has been confirmed in the Andes and in Central America. To characterize PMTV isolates from the Andes, soil...... samples were taken from the main potato-producing regions in Colombia and virus was recovered by planting Nicotiana benthamiana as bait plants. The complete genomes of five isolates were sequenced and three of the isolates were inoculated to four different indicator plants. Based on sequence comparisons...

PROPAGANDA POLITIK PARTAI GERINDRA DALAM GAME MAS GARUDA PADA PEMILU 2014 (Analisis Deskriptif Game Online Mas Garuda

Directory of Open Access Journals (Sweden)

Angga Satrya Putra

2016-03-01

Full Text Available The purpose of this study was to determine how the meaning of the look and content of the online game “Garuda Mas”. This game contains aspects of politically charged designations so that it can become a propaganda technique. The subject of this study is the game “Garuda Mas” which has been input on social media Facebook.Methods of data collection using documentary and literature. Data analysis using descriptive techniques. Data validity checking techniques using triangulation source.The results showed that the game “MAS GARUDA” can form the perspective of the players against Mas Garuda as a superhero figure hopes the Indonesian people who are able to overcome all the problems that exist in Indonesia. This game is a form of creative campaigns using propaganda techniques inserted in the game that has the power to change the mindset of every player. Change of mindset occurs because the player did not have an opportunity to think critically on aspects marking contained in the game. By indirectly the players will feel the emotional of this game and assume characterizations “Garuda Mas” in this game is a truth that can be believed.Keywords: Descriptive, Online Games, Mas Garuda, Partai Gerindra

A software framework for analysing solid-state MAS NMR data

International Nuclear Information System (INIS)

Stevens, Tim J.; Fogh, Rasmus H.; Boucher, Wayne; Higman, Victoria A.; Eisenmenger, Frank; Bardiaux, Benjamin; Rossum, Barth-Jan van; Oschkinat, Hartmut; Laue, Ernest D.

2011-01-01

Solid-state magic-angle-spinning (MAS) NMR of proteins has undergone many rapid methodological developments in recent years, enabling detailed studies of protein structure, function and dynamics. Software development, however, has not kept pace with these advances and data analysis is mostly performed using tools developed for solution NMR which do not directly address solid-state specific issues. Here we present additions to the CcpNmr Analysis software package which enable easier identification of spinning side bands, straightforward analysis of double quantum spectra, automatic consideration of non-uniform labelling schemes, as well as extension of other existing features to the needs of solid-state MAS data. To underpin this, we have updated and extended the CCPN data model and experiment descriptions to include transfer types and nomenclature appropriate for solid-state NMR experiments, as well as a set of experiment prototypes covering the experiments commonly employed by solid-sate MAS protein NMR spectroscopists. This work not only improves solid-state MAS NMR data analysis but provides a platform for anyone who uses the CCPN data model for programming, data transfer, or data archival involving solid-state MAS NMR data.

Multinuclear MAS NMR studies on coked zeolites H-ZSM-5

International Nuclear Information System (INIS)

Ernst, H.; Freude, D.; Hunger, M.; Pfeifer, H.

1991-01-01

During the cracking process carbonaceous materials are deposited on the outer or inner surface of the catalyst. These deposits are in many cases the main cause of catalyst deactivation. Magic angle spinning (MAS) NMR investigations and catalytic n-hexane cracking were carried out on H-ZSM-5 zeolites after a mild hydrothermal de-alumination. By 13 C CP MAS NMR it could be shown that the enhanced catalytic activity does not enhance the coke formation and that the chemical nature of these deposits is essentially aromatic. From 1 H MAS NMR studies performed on shallow-bed activated sealed samples and 27 Al and 29 Si MAS NMR on rehydrated samples it follows that for high coke concentrations the catalyst deactivation is caused mainly by blocking of Broensted acid sites. (author). 27 refs.; 3 figs.; 2 tabs

"Auge y Caída de la Masonería en México en el Siglo XIX. La Exclusión de la Mujer bajo la mirada del Discurso Masónico de Laureana Wright González"

OpenAIRE

Carlos Francisco MartÌnez Moreno

2012-01-01

La masonerÌa femenina en MÈxico fue efÌmera en el siglo XIX, surgiÛ con el apoyo de masones varones comprometidos con la educaciÛn de la mujer y su emancipaciÛn del dogma catÛlico, que no lograron emanciparse de los dogmas masÛnicos incoherentes con el progreso que decÌan defender; que por presiones de la masonerÌa internacional optaron por el conservadurismo de sus normas antes que perder el reconocimiento de la masonerÌa regular, con lo que...

Autolīzinga kompānijas AS "mogo" reklāmas kampaņu izstrāde, izmantojot Facebook reklāmas rīkus

OpenAIRE

Ābeltiņš, Elvis

2017-01-01

Diplomdarba tēma ir “Autolīzinga kompānijas AS “mogo” reklāmas kampaņu izstrāde, izmantojot Facebook reklāmas rīkus”. Vadošais sociālais tīkls Facebook nodrošina plašas reklāmas izvietošanas iespējas un tā auditorijas apjoms ir sasniedzis tradicionālajiem medijiem līdzvērtīgu izmēru. Darba analītiskajā daļā tiek kategorizētas digitālā mārketinga metodes, kā arī apkopota sociālo tīklu lietotāju statistika Latvijā un pasaulē. Projekta daļā autors salīdzina un analizē Facebook reklāmas izvietoša...

AutoMOPS--B2B and B2C in mask making: mask manufacturing performance and customer satisfaction improvement through better information flow management

Science.gov (United States)

de Ridder, Luc; Filies, Olaf; Rodriguez, Ben; Kuijken, Aart

2001-04-01

Through application of modern supply chain concepts in combination with state-of-the-art information technology, mask manufacturing performance and customer satisfaction can be improved radically. The AutoMOPS solution emphasizes on the elimination of the order verification through paperless, electronically linked information sharing/exchange between chip design, mask production and prototype production stages.

KINERJA USAHA TANAMAN HIAS POTONG PT PESONA DAUN MAS ASRI

Directory of Open Access Journals (Sweden)

Muhamad Arief Bangun Sanjaya

2017-01-01

Full Text Available Pesona Daun Mas Asri is a company in cut flowers  and leaves cultivation. The  achievement is shown by the performance of the company. The overall company’s performance contributes in developing the company’s vision. Balanced score card is a management tool used to observe and maintain the stability between financial indicators (financial perspective and non financial indicators (customer, business internal process, growth and learning.  The objective of the journal is to plan the performance of the company using balanced scorecard approach, analyze and calculate the vision, mission and strategy implemented by Pesona Daun Mas in it business activity..  The result for every strategic target shows that the performance of Pesona Daun Mas is excellent with the achieved score of 78,04%.  However the target for the selling growth level and marketing activities are classified as average which means that it still needs to be developed.   Keywords:  balanced scorecard, performance evaluation, KPI performance index, ornamental plants cutAbstrakPesona Daun Mas Asri merupakan perusahaan yang bergerak dalam bidang budi daya bunga potong dan daun potong. Pencapaian dalam menjalankan sebuah perusahaan dapat dilihat dari kinerja perusahaan tersebut.Kinerja perusahaan Pesona Daun Mas Asri secara keseluruhan dapat berkontribusi untuk mengembangkan perusahaan dalam mencapai visi. Balanced scorecard adalah salah satu alat manajemen yang dapat melihat dan menjaga keseimbangan antara indikator keuangan (perspektif keuangan dan indikator non-keuangan (pelanggan, proses bisnisinternal, pertumbuhan dan pembelajaran. Tujuan dari jurnal ini adalah untuk merancang pengukuran kinerja perusahaan dengan pendekatan Balanced scorecard. Penelitian ini juga bertujuan menganalisis dan mengukur pelaksanaan visi, misi dan strategi yang dijalankan oleh Pesona Daun Mas Asri dalam kegiatan bisnisnya. Selain itu, memberikan saran dan rekomendasi, serta merumuskan implikasi

KERAGAAN PERTUMBUHAN BENIH IKAN MAS (Cyprinus carpio STRAIN MAJALAYA, LOKAL BOGOR DAN RAJADANU DI KOLAM CIJERUK, BOGOR-JAWA BARAT

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Otong Zenal Arifin

2016-11-01

Full Text Available Penelitian ini bertujuan untuk mendapatkan strain ikan mas yang memiliki keragaan pertumbuhan yang baik sebagai spesies kandidat untuk program seleksi. Tiga strain ikan mas (majalaya, lokal Bogor, dan rajadanu dipelihara dalam jaring yang diletakkan di kolam Instalasi Penelitian Cijeruk, Bogor selama 6 minggu. Hasil penelitian menunjukkan bahwa tidak ada perbedaan nyata untuk parameter pertambahan bobot dan sintasan dari 3 strain ikan mas yang diuji, sedangkan untuk pertambahan panjang individual (mm per bulan ada perbedaan yang sangat nyata (P<0,05. Strain ikan mas rajadanu memiliki pertambahan panjang terbaik (16,0 ± 1,41 dan berbeda dengan majalaya (10,3 ± 4,50 serta lokal (10,8 ± 2,06. Objective of this study is to produce good performance of common carp by comparing three promising strains majalaya, local, and rajadanu. The study was carry out using floating net cages placed in earthen pond at The Cijeruk Germ Plasm Research Station. During the study, growth and survival rate were observed were observed for six weeks. The results indicated there was no significant difference for growth of weight and survival rate. However, growth of standard length was significantly different (P<0.05. Rajadanu made the best growth of standard length (16.0 ± 1.41 and was different from majalaya (10.3 ± 4.50 and local strain (10.8 ± 2.06.

Diseñe su interfaz gráfica con Matlab

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Miguel Ramón Ortegón Gutiérrez

1998-05-01

Full Text Available Las aplicaciones de carácter científico o tecnológico cuentan, para su desarrollo, con el apoyo de una poderosa herramienta de cálculo numérico, que permite abordar problemas que demanden variada y compleja manipulación matemática de manera eficiente y con ayudas gráficas. Su diseño funcional le permite usar con facilidad toda la gama de comandos en forma interactiva, o en modo programas que han sido implementados como parte del lenguaje, o los nuevos comandos implementados por el usuario. Problemas tradicionales, relativos al manejo de matrices o álgebra lineal, cálculo diferencial e integral, ecuaciones diferenciales, raíces de funciones, solución de sistemas de ecuaciones, etc., hasta algunos más especializados como el procesamiento digital de señales, redes neuronales, filtros, pueden ser tratados con este lenguaje. Con el presente artículo se desea difundir el uso de interfaces gráficas que provee Matlab, para hacer más modernas, presentables y manejables aplicaciones de ingeniería que con otras herramientas podrían resultar mas complicadas y engorrosas.

Fracturas de tibia, tratamiento con CIMB no fresados

Directory of Open Access Journals (Sweden)

Roberto Del Gordo D´Amato

2013-10-01

Full Text Available Se realizó un estudio descriptivo tipo serie de casos en el cual se analizan diversos aspectos inherentes al tratamiento quirúrgico de 92 fracturas de tibia diafisiarias cerradas y abiertas tipo I y II de Gustillo, tratadas con Clavos Intramedulares Bloqueados No Fresados (CIMBNF de las 125 atendidas servicio de ortopedia y traumatología de la Clínica El Prado de la Ciudad de Santa Marta D.T.C.H., entre diciembre del 2005 y diciembre del 2007. Se excluyeron de este estudio 33 casos en los cuales por diversas causas se realizó otro tipo de tratamiento fuera ortopédico o quirúrgico mediante colocación de fijadores externos. Utilizamos la clasificación del AO en la cual a este tipo de lesiones corresponde el número 42. Encontramos una alta incidencia en accidentes de transito como factor productor de este tipo de lesión y dentro de ellos la motocicleta como vehículo mas frecuente. Fueron evaluados 86 de los 92 pacientes que corresponde al 93.5% y dentro de ellos se presentaron complicaciones mayores en el 4.6%, cabe mencionar Infecciones post operatorias y deformidades a nivel proximal y distal por diversas causas, las cuales fueron corregidas con procedimientos ulteriores. (Duazary 2008; 1: 4 - 8

Identificación de mutaciones puntuales del gen de la 21-hidroxilasa en pacientes afectados con hiperplasia suprarrenal congénita.

Directory of Open Access Journals (Sweden)

Dora Fonseca

2005-06-01

Full Text Available lntroducción. La hiperplasia suprarrenal congénita es un trastorno autosómico recesivo debido a la inadecuada secreción de cortisol. Mas del 95% de los casos de hiperplasia suprarrenal congénita son causados por defectos del gen de la 21 hidroxilasa, CYP21A2 . Las manifestaciones clínicas incluyen la forma clásica y la forma no clásica. Objetivos. Determinar la frecuencia de las mutaciones puntuales P30L, IVS2-12AIC-G, Del 8pb, I172N, cluster Ex 6, V281L, Q318X, R356W y P453S en pacientes con hiperplasia suprarrenal congénita. Materiales y métodos. Se estudiaron 58 pacientes, de los cuales, 48 fueron clásicos y 10 no clásicos. Mediante PCR alelo-especifica y ACRS (Amplified Creation Restriction Sites, se analizaron 9 mutaciones puntuales del gen CYP21A2 y se determinó la frecuencia en la población analizada. Resultados. Los alelos afectados se identificaron en el 82,8% de los cromosomas. Las mutaciones mas frecuentes fueron: IVS2-12AIC-G (26,7%, Q318X (21,5%, V281L (12,1% e I172N (12,1%. Conclusiones. Las mutaciones mas frecuentes en Colombia son similares a las de otros países del mundo, excepto para Q318X que presentó una mayor frecuencia, pero similar a la de otros países latinoamericanos. Este hallazgo y la existencia de 17,2% de alelos no identificados puede indicar diferencia entre el acervo genético de las poblaciones. En la forma clásica perdedora de sal predominaron las mutaciones Q318X e IVS2-12AIC-G; en la virilizante simple, IVS2-12AIC-G e I172N y en la no clásica , V281L, lo cual esta relacionado con el grado de actividad enzimática. En la forma no clásica, se encontraron alelos severos en el 66,7% de los casos, lo que determina el riesgo de tener hijos afectados con la forma grave virilizante simple o perdedora de sal. Los resultados reportados permiten ofrecer asesoramiento genético y diagnóstico prenatal.

ESTUDIO DEL EFECTO COMPARATIVO SOBRE EL DOLOR Y LAS PARESTESIAS EN LA NEUROPATIA DIABETICA TRATADA CON ACUPUNTURA CON DOS FORMULAS DE PUNTOS

OpenAIRE

MUNOZ SAMAYOA, ENRIQUE

2010-01-01

LA NEUROPATIA DIABETICA ES UN DESORDEN CIRCULATORIO RELACIONADO CON LAS ALTERACIONES EN LA PERCEPCION SOMATOSENSITIVA, ES LA CAUSA DE DOLOR Y SENSACIONES PARESTESICAS. EL OBJETIVO DE ESTE TRABAJO ES DEMOSTRAR EL EFECTO ANALGESICO DE LA ACUPUNTURA EN EL MANEJO DE LA NEUROPATIA DIABETICA Y COMPARAR EL EFECTO EN LA REDUCCION DEL DOLOR Y DE LAS PARESTESIAS USANDO ZUSANLI E36, SANYINJIAO B6, XUEHAI B10, TAICHONG H3 COMO SELECCION ESTANDAR DE LOS ACUPUNTOS CONTRA LOS MISMOS PUNTOS MAS YUANYUE ...

Photoprotective effect of a psoralen-UVA-induced tan

International Nuclear Information System (INIS)

Gschnait, F.; Brenner, W.; Wolff, K.

1978-01-01

To determine whether a tan produced by 8-MOP and UVA protects from subsequent solar light irradiation, volunteers were irradiated with unfiltered Xenon arc light before and 10 days after a 1 week's course of four 8-MOP-UVA treatments. Evaluation of the minimal erythema doses and of histological changes before and after 8-MOP-UVA treatment revealed that the 8-MOP-UVA induced tan protected against the erythemogenic and cell damaging effects of Xenon arc light. Unscheduled repair DNA synthesis, used as a measure for UVB-induced DNA damage and repair, was also investigated in skin irradiated with the Xenon arc before and after 8-MOP-UVA induced tanning. Both the number of grains per sparse labeled cell and the number of sparse labeled cells per 1000 cells, were found to be significantly lower in tanned skin; taking decreased unscheduled repair DNA synthesis as a measure for decreased DNA-damage, these findings also demonstrate a photoprotective effect of the 8-MOP-UVA induced tan. (orig.) [de

E/Z MAS: An easy-to-use computerized materials control and accountability system

International Nuclear Information System (INIS)

Anderson, L.K.; Boor, M.G.; Hurford, J.M.; Landry, R.P.; Martinez, B.J.; Solem, A.M.; Whiteson, R.; Zardecki, A.

1998-01-01

Nuclear facilities that handle and process nuclear materials are required to track their nuclear holdings and to keep adequate records that manage and control the inventory of those holdings. The complexity of a system that does this job is directly proportional to the complexity of the facility's operations. This paper describes an approach to computerized materials protection, control, and accountability (MPC and A) that was introduced by Los Alamos National Laboratory (LANL) in the fall of 1997. This new system, E/Z MAS, is the latest addition to the LANL suite of computerized MPC and A tools, which also includes the CoreMAS system. E/Z MAS was initially designed to address the needs of those facilities that have small to modest MPC and A needs but has been expanded to provide full functionality for any facility. The system name, E/Z MAS, reflects the system's easy-to-use characteristics, which include ease of installation and ease of software maintenance. Both CoreMAS and E/Z MAS have been provided to facilities in the Former Soviet Union to assist them in implementing a computerized MPC and A system that meets their needs. In this paper the authors will address the functionality of CoreMAS and E/Z MAS, and an argument in favor of intranet-based material control and accountability will be advanced

A fast, noniterative approach for accelerated high-temporal resolution cine-CMR using dynamically interleaved streak removal in the power-spectral encoded domain with low-pass filtering (DISPEL) and modulo-prime spokes (MoPS).

Science.gov (United States)

Kawaji, Keigo; Patel, Mita B; Cantrell, Charles G; Tanaka, Akiko; Marino, Marco; Tamura, Satoshi; Wang, Hui; Wang, Yi; Carroll, Timothy J; Ota, Takeyoshi; Patel, Amit R

2017-07-01

To introduce a pair of accelerated non-Cartesian acquisition principles that when combined, exploit the periodicity of k-space acquisition, and thereby enable acquisition of high-temporal cine Cardiac Magnetic Resonance (CMR). The mathematical formulation of a noniterative, undersampled non-Cartesian cine acquisition and reconstruction is presented. First, a low-pass filtering step that exploits streaking artifact redundancy is provided (i.e., Dynamically Interleaved Streak removal in the Power-spectrum Encoded domain with Low-pass filtering [DISPEL]). Next, an effective radial acquisition for the DISPEL approach that exploits the property of prime numbers is described (i.e., Modulo-Prime Spoke [MoPS]). Both DISPEL and MoPS are examined using numerical simulation of a digital heart phantom to show that high-temporal cine-CMR is feasible without removing physiologic motion vs aperiodic interleaving using Golden Angles. The combined high-temporal cine approach is next examined in 11 healthy subjects for a time-volume curve assessment of left ventricular systolic and diastolic performance vs conventional Cartesian cine-CMR reference. The DISPEL method was first shown using simulation under different streak cycles to allow separation of undersampled radial streaking artifacts from physiologic motion with a sufficiently frequent streak-cycle interval. Radial interleaving with MoPS is next shown to allow interleaves with pseudo-Golden-Angle variants, and be more compatible with DISPEL against irrational and nonperiodic rotation angles, including the Golden-Angle-derived rotations. In the in vivo data, the proposed method showed no statistical difference in the systolic performance, while diastolic parameters sensitive to the cine's temporal resolution were statistically significant (P cine). We demonstrate a high-temporal resolution cine-CMR using DISPEL and MoPS, whose streaking artifact was separated from physiologic motion. © 2017 American Association of Physicists

The mutagenic effect of near ultraviolet light on the nvs strains of Aspergillus nidulans in the presence of 8-metoxypsoralen or angelicin

International Nuclear Information System (INIS)

Muronets, E.M.; Kovtunenko, L.V.; Kameneva, S.V.

1980-01-01

The mutual mutagenic effect of long-wave ultraviolet radiation (EUV) with angelicin which forms monoadducts in DNA and 8-metoxypsoralen (8 MOP) which forms monoadducts and joints, on conidia of uvs- and uvs+ strains of Aspergillus nidulans, is studied. The two types of interaction are shown to induce mutations intensively. Mutation induction with angelicin shows the role of psoralen pyrimidine monoadducts in mutagenesis. The technique of fractionated EUV radiation and studying the effect of monoadduct repair effectiveness on mutation output permits to prove that interthread DNA joints induced by 8-MOP+EUV are also highly mutagenous. The products of UVS/2, 20b, 26 genes which take part in the excision of DNA damages do not take part in the formation of mutations induced in aspergil by furocoumarine + EUV. The products of uvs 19, 20a genes which take part in the postreplicative DNA reduction are neccessary for the repair of premutation damages induced by furocoumarine + EUV

Residue specific hydration of primary cell wall potato pectin identified by solid-state 13C single-pulse MAS and CP/MAS NMR spectroscopy

DEFF Research Database (Denmark)

Larsen, Flemming Hofmann; Chrestensen, Inge Byg; Damager, Iben

2011-01-01

Hydration of rhamnogalacturonan-I (RG-I) derived from potato cell wall was analyzed by 13C single-pulse (SP) magic-angle-spinning (MAS) and 13C cross-polarization (CP) MAS nuclear magnetic resonance (NMR) and supported by 2H SP/MAS NMR experiments. The study shows that the arabinan side chains...... hydrate more readily than the galactan side chains and suggests that the overall hydration properties can be controlled by modifying the ratio of these side chains. Enzymatic modification of native (NA) RG-I provided samples with reduced content of arabinan (sample DA), galactan (sample DG), or both side...... chains (sample DB). Results of these samples suggested that hydration properties were determined by the length and character of the side chains. NA and DA exhibited similar hydration characteristics, whereas DG and DB were difficult to hydrate because of the less hydrophilic properties of the rhamnose...

Quartz Crystal Temperature Sensor for MAS NMR

Science.gov (United States)

Simon, Gerald

1997-10-01

Quartz crystal temperature sensors (QCTS) were tested for the first time as wireless thermometers in NMR MAS rotors utilizing the NMR RF technique itself for exiting and receiving electro-mechanical quartz resonances. This new tool in MAS NMR has a high sensitivity, linearity, and precision. When compared to the frequently used calibration of the variable temperature in the NMR system by a solid state NMR chemical shift thermometer (CST), such as lead nitrate, QCTS shows a number of advantages. It is an inert thermometer in close contact with solid samples operating parallel to the NMR experiment. QCTS can be manufactured for any frequency to be near a NMR frequency of interest (typically 1 to 2 MHz below or above). Due to the strong response of the crystal, signal detection is possible without changing the tuning of the MAS probe. The NMR signal is not influenced due to the relative sharp crystal resonance, restricted excitation by finite pulses, high probeQvalues, and commonly used audio filters. The quadratic dependence of the temperature increase on spinning speed is the same for the QCTS and for the CST lead nitrate and is discussed in terms of frictional heat in accordance with the literature about lead nitrate and with the results of a simple rotor speed jump experiment with differently radial located lead nitrate in the rotor.

La materia orgánica particulada: comparación de métodos para su determinación y su valor como indicador de calidad de suelos del Chubut Particulate organic-matter: a comparison of methods for its determination and its role as an indicator of soil quality for some soils in the province of Chubut

Directory of Open Access Journals (Sweden)

Lina Sonia Videla

2008-12-01

Full Text Available La materia orgánica particulada (MOP es un componente dinámico del suelo, que responde selectiva y rápidamente a los cambios de manejo y distintos tipos de disturbios. El objetivo de este estudio fue comparar dos técnicas de determinación de MOP en distintos suelos y evaluar el potencial de esta variable como indicadora de calidad de los mismos. Se estudiaron tres sitios ecológicos de la provincia del Chubut con distinto manejo o afectados por distintos disturbios: Media Luna Clausura (ML C, Media Luna Pastoreo (ML P, Puerto Madryn bioperturbado (PM B, Puerto Madryn no bioperturbado (PM NB, Punta Ninfas no erosionado (PN NE y Punta Ninfas erosionado (PN E. En muestras de suelos extraídas de 0 a 5 cm (PM y PN y de 0 a 10 cm (ML de profundidad se determinó la materia orgánica total (MOT y la MOP por vía húmeda (MOPh (Método Walkley y Black y por ignición en mufla (MOPi a 430 °C. En los Molisoles de ML y en los Aridisoles de PM la MOPi fue mayor que la MOPh, mientras que para los Aridisoles de PN no se registraron diferencias significativas entre los dos métodos. Para los suelos con carbonatos (PM o con alofanos (ML, el método por ignición sobreestimó los contenidos de MOP. La MOT presentó una alta correlación con la MOPh y con la MOPi para todos los suelos en conjunto (r² = 0,89 y r² = 0,73, respectivamente. El suelo que presentó una mayor relación MOP/MOT fue PN NE. En contraste, el suelo PN E, mostró los valores más bajos para esta relación, lo que indicaría, por un lado, que la poca MO que contienen estos suelos está predominantemente asociada a la fracciónParticulate organic-matter (MOP is a dynamic soil component that quickly and selectively responds to management changes and to different disturbance regimes. We compared two techniques to determine the MOP content in different soils and assessed the potential of this variable as an indicator of soil quality. We studied the soils of three ecological sites located

"Auge y Caída de la Masonería en México en el Siglo XIX. La Exclusión de la Mujer bajo la mirada del Discurso Masónico de Laureana Wright González"

Directory of Open Access Journals (Sweden)

Carlos Francisco MartÌnez Moreno

2012-01-01

Full Text Available La masonerÌa femenina en MÈxico fue efÌmera en el siglo XIX, surgiÛ con el apoyo de masones varones comprometidos con la educaciÛn de la mujer y su emancipaciÛn del dogma catÛlico, que no lograron emanciparse de los dogmas masÛnicos incoherentes con el progreso que decÌan defender; que por presiones de la masonerÌa internacional optaron por el conservadurismo de sus normas antes que perder el reconocimiento de la masonerÌa regular, con lo que excluyeron a la mujer de la masonerÌa.

Angiotensin-(1-7)/Mas axis integrity is required for the expression of object recognition memory.

Science.gov (United States)

Lazaroni, Thiago L N; Raslan, Ana Cláudia S; Fontes, Walkiria R P; de Oliveira, Marilene L; Bader, Michael; Alenina, Natalia; Moraes, Márcio F D; Dos Santos, Robson A; Pereira, Grace S

2012-01-01

It has been shown that the brain has its own intrinsic renin-angiotensin system (RAS) and angiotensin-(1-7) (Ang-(1-7)) is particularly interesting, because it appears to counterbalance most of the Ang II effects. Ang-(1-7) exerts its biological function through activation of the G-protein-coupled receptor Mas. Interestingly, hippocampus is one of the regions with higher expression of Mas. However, the role of Ang-(1-7)/Mas axis in hippocampus-dependent memories is still poorly understood. Here we demonstrated that Mas ablation, as well as the blockade of Mas in the CA1-hippocampus, impaired object recognition memory (ORM). We also demonstrated that the blockade of Ang II receptors AT1, but not AT2, recovers ORM impairment of Mas-deficient mice. Considering that high concentrations of Ang-(1-7) may activate AT1 receptors, nonspecifically, we evaluate the levels of Ang-(1-7) and its main precursors Ang I and Ang II in the hippocampus of Mas-deficient mice. The Ang I and Ang II levels are unaltered in the whole hipocampus of MasKo. However, Ang-(1-7) concentration is increased in the whole hippocampus of MasKo mice, as well as in the CA1 area. Taken together, our findings suggest that the functionality of the Ang-(1-7)/Mas axis is essential for normal ORM processing. Copyright © 2011 Elsevier Inc. All rights reserved.

Effect of 8-methoxypsoralen plus long-wave ultraviolet (PUVA) radiation on mast cells. II. In vitro PUVA inhibits degranulation of rat peritoneal mast cells induced by compound 48/80

International Nuclear Information System (INIS)

Toda, K.; Danno, K.; Tachibana, T.; Horio, T.

1986-01-01

Rat peritoneal mast cells incubated with a histamine liberator, compound 48/80, showed a significantly reduced capacity for releasing histamine following in vitro treatment with 0.1 micrograms/ml of 8-methoxypsoralen (8-MOP) plus 1-5 J/cm2 of long-wave ultraviolet (UVA) irradiation (PUVA). No remarkable inhibition in histamine release was observed in the cells treated with 8-MOP only. Irradiation with 5 J/cm2 of UVA alone exerted an inhibitory effect on histamine release, to a lesser extent than PUVA. PUVA irradiation did not bring any decrease in cell viability or any spontaneous release of histamine from irradiated cells as shown by phase-contrast microscopy and by histamine assay, respectively. These results suggest that PUVA treatment may cause a noncytotoxic disturbance at mast cell membranes or on surface receptors, leading to a decreased capacity for secreting chemical mediators

Reducing radiation dose in liver enhanced CT scan by setting mAs according to plain scan noise

International Nuclear Information System (INIS)

Yang Shangwen; He Jian; Yang Xianfeng; Zhou Kefeng; Xin Xiaoyan; Hu Anning; Zhu Bin

2013-01-01

Objective: To investigate the feasibility of setting mAs in liver enhanced CT scan according to plain scan noise with fixed mA CT scanner, in order to reduce the radiation dose. Methods: One hundred continuous patients underwent liver enhanced CT scan (group A) prospectively. Two hundred and fifty mAs was used in plain and enhanced CT scans. Noises of plain and venous phase CT images were measured, and the image quality was evaluated. The equation between mAs of enhanced scan and noise of plain scan image was derived. Another 100 continuous patients underwent liver enhanced CT scan (group B). Enhanced scan mAs was calculated from noise on plain scan by using the equation above. Noises on venous phase images were measured and the image quality was measured. Based on body mass index (BMI), patients in groups A and B were divided into three subgroups respectively: BMI < 18.5 kg/m 2 , 18.5 kg/m 2 ≤ BMI < 25.0 kg/m 2 and BMI ≥ 25.0 kg/m 2 . Image quality score was compared with nonparametric rank sum test, CT dose index (CTDI) and effective dose (ED) were measured and compared between each subgroup with 2 independent samples t or t' test. Results: The equation between enhanced scan mAs (mAsX) and plain scan noise (SDp) was as follows: mAsX = mAs1 × [(0.989 × SDp + 1.06) /SDx] 2 , mAs1 = 250 mAs, SDx = 13. In patients with BMI < 18.5 kg/m 2 , ED of group A [(6.86 ± 0.38) mSv, n = 12] was significantly higher than group B [(2.66 ± 0.46) mSv, n = 10)] (t = 18.52, P < 0.01). In patients with 18.5 kg/m 2 ≤ BMI < 25.0 kg/m 2 , ED of group A [(7.08 ± 0.91) mSv, n = 66] was significantly higher than group B [(4.50 ± 1.41) mSv, n = 73] (t' = 10.57, P < 0.01). In patients with BMI ≥ 25.0 kg/m 2 , there was no significant difference between EDs of group A (7.54 ± 0.62 mSv, n = 22) and group B [(8.19 ± 3.16) mSv, n = 17] (t' = 0.89, P = 0.39). Image quality of 5 patients in group A and none in group B did not meet the diagnostic requirement

Lesiones orales asociadas con la infección por VIH/sida en individuos sin tratamiento antirretroviral en el Hospital San Juan de Dios de Bogotá

Directory of Open Access Journals (Sweden)

John Harold Estrada

2001-12-01

Full Text Available El reconocimiento de las lesiones orales asociadas con el VIH es de gran importancia, ya que pueden representar el primer signo de la infección y servir como predictoras de inmunosupresión y del desarrollo de sida en pacientes infectados. Se realizó un estudio descriptivo de 314 pacientes con VIH que eran atendidos en el programa integral del Hospital San Juan de Dios de Bogotá. Se les practicó examen fisico completo y examen oral; se registró el tipo de lesión, el lugar de presentación, el género y la edad. De los sujetos examinados, 285 (90,8% eran del sexo masculino y 29 (9,2% del femenino. El promedio de edad fue de 31 años (rango: 15 a 64. No se encontraron lesiones orales asociadas en 91 (29%, mientras que en los restantes 223 (71% se anotaron una o mas lesiones; la más frecuente fue la candidosis oral en 207 personas (65,8%. Al subdividirla en sus cuatro variedades, se encontró la forma seudomembranosa en 94 pacientes (29,9%; la eritematosa en 66 (21%; la queilitis angular en 38 (12.1% y la hiperplásica en 9 (2.8% Le siguió en frecuencia la leucoplasia vellosa en 67 sujetos (21.3%, la gingivitis y la periodontitis en 54 (17.1%, el sarcoma de Kaposi en 28 (8.9% y la estomatitis aftosa recurrente en 26 (8,2%. Los lugares mas afectados fueron el paladar duro y blando en 108 sujetos (34,4%, la lengua en 101 (32.2%, la mucosa yugal en 48 (15.3%, la encia marginal en 36 (11.5%, la comisura labial en 34 (10,8% y la orofaringe en 25 (8%. Estos hallazgos permiten definir el perfil especifico de morbilidad oral de los pacientes del Hospital San Juan de Dios en Bogotá para el período estudiado.

Análisis de la masa ósea periprotésica en prótesis total de rodilla tras tratamiento con denosumab: resultados clínicos y densitométricos /

OpenAIRE

González Rodríguez, José Carlos,

2017-01-01

Introducción: La masa ósea periprotésica (MOP) tras la implantación de una prótesis de rodilla (ATR) se ve disminuida por diferentes factores y puede ser causa de complicaciones como fracturas periprotésicas y, a largo plazo, de aflojamientos asépticos con necesidad de ser revisadas quirúrgicamente. La fijación inicial de una prótesis articular es de vital importancia en su supervivencia a largo plazo. En caso de que esta fijación sea deficitaria o no se produzca, la superficie ósea sufre un ...

Análisis de la masa ósea periprotésica en prótesis total de rodilla tras tratamiento con denosumab. resultados clínicos y densitométricos

OpenAIRE

González Rodríguez, José Carlos

2017-01-01

INTRODUCCIÓN La masa ósea periprotésica (MOP) tras la implantación de una prótesis de rodilla(ATR) se ve disminuida por diferentes factores y puede ser causa de complicaciones como fracturas periprotésicas y, a largo plazo, de aflojamientos asépticos con necesidad de ser revisadas quirúrgicamente. La fijación inicial de una prótesis articular es de vital importancia en su supervivencia a largo plazo. En caso de que esta fijación sea deficitaria o no se produzca, la superficie ósea sufre u...

Combustion of drops of Mexican fuel oils with high asphaltenes content; Combustion de gotas de combustoleos mexicanos con alto contenido de asfaltenos

Energy Technology Data Exchange (ETDEWEB)

Garcia Rodriguez, Jose Francisco [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

1998-09-01

In this work the combustion of fuel drops with a content of 18% of asphaltenes has been studied . The results obtained for this fuel were compared with the ones obtained for another with a content of 12% asphaltenes. The drops were suspended in a platinum filament and burned in an spherical radiant furnace. The drop size varied between 600 and 800 microns. The fuel drops with 12% asphaltenes showed shorter combustion times, a smaller diameter increment of the smaller diameter during the combustion stages and also a shorter burning time of the carbonaceous residue than the fuel drops with a content of 18% asphaltenes. [Espanol] En el presente trabajo se ha estudiado la combustion de gotas de combustible con 18% de contenido de asfaltenos. Los resultados obtenidos para este combustible se compararon con los obtenidos para otro con 12% de contenido de asfaltenos. Las gotas fueron suspendidas en un filamento de platino y quemadas en un horno radiante esferico. El tamano de las gotas vario entre 600 y 800 micras. Las gotas de combustible con 12% de asfaltenos mostraron tiempos de combustion mas cortos, un incremento del diametro menor durante las etapas de combustion y un tiempo de quemado del residuo carbonoso tambien mas corto que las gotas del combustible con 18% de contenido de asfaltenos.

Neuroprotective Mechanisms of the ACE2-Angiotensin-(1-7)-Mas Axis in Stroke

DEFF Research Database (Denmark)

Bennion, Douglas M; Haltigan, Emily; Regenhardt, Robert W

2015-01-01

The discovery of beneficial neuroprotective effects of the angiotensin converting enzyme 2-angiotensin-(1-7)-Mas axis [ACE2-Ang-(1-7)-Mas] in ischemic and hemorrhagic stroke has spurred interest in a more complete characterization of its mechanisms of action. Here, we summarize findings that desc......The discovery of beneficial neuroprotective effects of the angiotensin converting enzyme 2-angiotensin-(1-7)-Mas axis [ACE2-Ang-(1-7)-Mas] in ischemic and hemorrhagic stroke has spurred interest in a more complete characterization of its mechanisms of action. Here, we summarize findings...... that describe the protective role of the ACE2-Ang-(1-7)-Mas axis in stroke, along with a focused discussion on the potential mechanisms of neuroprotective effects of Ang-(1-7) in stroke. The latter incorporates evidence describing the actions of Ang-(1-7) to counter the deleterious effects of angiotensin II...... complete understanding of the mechanisms of action of Ang-(1-7) to elicit neuroprotection will serve as an essential step toward research into potential targeted therapeutics in the clinical setting....

Efecto del medio y condiciones de cultivo en la productividad de tres diatomeas marinas con potencial acuícola

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Martha J. Prieto

2005-05-01

Full Text Available Las diatomeas Actinocyclus normanii , Cyclotella gromerata y Neodelphyneis pelagica fueron trabajadas en ellaboratorio de Alimento Vivo de la Universidad de Córdoba, con el fin de caracterizar las especies, obtenercepas y realizar cultivos experimentales bajo condiciones controladas de temperatura (24oC, salinidad (25-300/00 y aireación. Cultivos a 5 ml y 250 ml fueron realizados con dos medios de cultivo como tratamiento (F/2 deGuillar & Rither, y CONWAY para determinar su efecto sobre la productividad. Mediante observaciones periódicas(cada 6 horas, se registró el tamaño y densidad celular, así como, la tasa de crecimiento (K. Los resultadosmostraron diferencia significativa para el efecto de los medios de cultivo sobre el crecimiento poblacional de lasmicroalgas, las cuales alcanzan concentraciones de 267214,1 ± 277,77 cel.ml-1; 1606117 ± 69686,7 cel.ml-1 y 2735703 ± 49180,8 cel.ml-1 respectivamente para cada especie. Se concluyó que estas microalgas por suscaracterísticas de crecimiento en cultivo, presentan adaptación favorable a las condiciones de manejo para laproducción de biomasas frescas con “F/2” siendo este el medio mas adecuado, asimismo, por su tamaño sonpotencialmente útiles para ser empleadas como partícula nutritiva con fines acuícolas.

The evolution of the MasAgro hubs

NARCIS (Netherlands)

Camacho-Villa, Tania Carolina; Almekinders, Conny; Hellin, Jon; Martinez-Cruz, Tania Eulalia; Rendon-Medel, Roberto; Guevara-Hernández, Francisco; Beuchelt, Tina D.; Govaerts, Bram

2016-01-01

Purpose: Little is known about effective ways to operationalize agricultural innovation processes. We use the MasAgro program in Mexico (which aims to increase maize and wheat productivity, profitability and sustainability), and the experiences of middle level ‘hub managers’, to understand how

Estudio para el desarrollo y optimización del espumado de policarbonato con agentes de siembra en el proceso de inyección

OpenAIRE

Vargas Isaza, Carlos Andrés

2012-01-01

1 CD-ROM El presente trabajo aborda el desarrollo experimental para obtener piezas inyectadas espumadas en policarbonato (ver anexo 10.1.1), con características de alta densidad de espuma, mediante la incorporación de agentes nucleantes, tales como cargas inorgánicas y/o nanocargas. Con lo anterior, se busca implementar un proceso alternativo de espumado por inyección, el cual sea mas económico que los procesos comerciales, los cuales requieren una gran inversión en equipos. Se comenzó con...

Tendencias clave para el tercer gobierno del MAS, Bolivia 2015-2019

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Xavier Albó

2016-03-01

Esta presentación tiene como trasfondo el Plan Nacional de Desarrollo y pretende resaltar algunos de los logros del presidente Evo Morales y los desafíos que enfrenta en su tercer gobierno (2015-2019. Comienza revisando información demográfica básica, según el Censo de 2012, para luego centrarse en la economía: los hidrocarburos, la minería, la producción agropecuaria y la ecología. El boom de la quinua, la expansión de la frontera agrícola y la suspensión de la construcción de una carretera que atraviese el TIPNIS son algunos de los temas que se discuten. Internacionalmente, hay motivos de optimismo con relación a la demanda marítima de Bolivia, mientras que, a nivel nacional, el MAS aseguró una victoria parlamentaria en el año 2014. Las reformas menos exitosas son las del órgano judicial. La presentación termina revisando los movimientos sociales que permitieron la formación la de Asamblea Constituyente y el asunto de la autonomía municipal, departamental e indígena.

Reconstrucción de Piso Orbitario con esclera en Fracturas del Tercio Medio. Presentación de caso

OpenAIRE

Alexis A. Amador-Velázquez; Martha Rodríguez-Milord; Reynaldo Oro-Canelles

2011-01-01

Presentó un caso el cual fue víctima de una agresión con un objeto cortante que le produjo una fractura compleja del tercio medio facial provocándole una Fractura Le Fort III unilateral izquierda y Le Fort II unilateral derecha con herida perforante y extensa en globo ocular izquierdo que fue necesario realizar su eviseración, extrayendo de este un fragmento de esclera del segmento anterior de mas menos 1cm de largo para reparar una fractura mediana en piso orbital derecho logrando su fijaci...

Effectiveness of FitoMas-E in the cultivation of chickpea under two soil moisture levels

Directory of Open Access Journals (Sweden)

Yanitza Meriño Hernández

2018-01-01

Full Text Available To evaluate the effect of FitoMas-E on the performance of the chickpea, in conditions of drought stress, was the objective of this investigation. An experiment was conducted in the Intensive Garden "Río de Guisa" in the municipality of Guisa during the period from November to February 2014. Four treatments were applied, distributed in a randomized block design with three repetitions, on a "Pardo mullido grisaceo" soil, comparing the application of FitoMas-E under two soil moisture regimes, with and without water stress. The yield of grain and its components were evaluated at the time of harvest maturity, to analyze the responses of these variables to the treatments applied. An analysis of variance was performed using the statistical package STASTISTICA version 8.0 for Windows and the means of the treatments were compared using the Tukey Multiple Range test. The variables that showed a greater response to the treatments imposed were the number of legumes per plant, number of seeds per plant, the mass of 100 seeds and the yield of grain, which ranged between 0.9 and 0.93 t ha-1 for the treatments 2 and 4 respectively. The results obtained in this research showed that the chickpea crop achieved the best productive indicators when the plants were under water stress conditions and received the application of FitoMas-E.

Low dose multi-detector CT of the chest (iLEAD Study): Visual ranking of different simulated mAs levels

International Nuclear Information System (INIS)

Ley-Zaporozhan, Julia; Ley, Sebastian; Krummenauer, Frank; Ohno, Yoshiharu; Hatabu, Hiroto; Kauczor, Hans-Ulrich

2010-01-01

Purpose: Detailed evaluation of the lung parenchyma might be impaired by use of low dose CT as image noise increases and subsequently image quality decreases. The aim of our study was to determine the accuracy of visual perception of differences in image quality and noise at low dose chest CT. Materials and methods: Forty-four patients suffering from emphysema underwent CT (Aquilion-16, 120 kV, 150 mAs, 1 mm-collimation). Original raw data were used for simulation of 10 different mAs settings from 10 mAs to 100 mAs in 10 mAs increments. Three representative hard copy images (carina, 4 cm above, 5 cm below) were printed for evaluation of lung parenchyma (high-resolution kernel, lung window) and mediastinum (soft-kernel, soft tissue window). Ranking of expected low mAs level was performed for lung and soft tissue separately based on visual perception by three-blinded chest radiologist independently. Results were compared to the real simulated mAs. Results: The accuracy for correct ranking of the original 150 mAs scan was 89% for lung and 86% for soft tissue while it was 99% for the simulated 10 mAs for both windows. In comparison to the lowest mAs a significant error increase was found for the lung at 60-100 mAs (with error increase of 30-47%) for reader-I; 60-100 mAs for (33-64%) for reader-II and 70-100 mAs (38-57%) for reader-III. For the soft tissue: 60-150 mAs (with error increase of 28-63%) for reader-I; 50-100 mAs (35-56%) for reader-II and 50-90 mAs (35-40%) for reader-III. Conclusion: Simulated dose levels below 60 mAs (=42 mAs eff ) were clearly differentiated from higher dose levels by all readers. Therefore, imaging doses could be lowered down to 60 mAs without a diagnostically relevant increase in noise impairing image quality.

SecMAS: Security Enhanced Monitoring and Analysis Systems for Wireless Sensor Networks

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Ding Chao

2016-01-01

Full Text Available The monitoring, control, and security guarantee for the communication in the wireless sensor networks (WSNs are currently treated as three independent issues and addressed separately through specialized tools. However, most cases of WSNs applications requires the network administrator change the network configuration in a very short time to response to the change of observed phenomenon with security guarantee. To meet this requirement, we propose a security enhanced monitoring and control platform named SecMAS for WSNs, which provides the real-time visualization about network states and online reconfiguration of the network properties and behaviours in a resource-efficient way. Besides, basic cryptographic primitives and part of the anomaly detection functionalities are implemented in SecMAS to enabling the secure communication in WSNs. Furthermore, we conduct experiments to evaluate the performance of SecMAS in terms of the latency, throughput, communication overhead, and the security capacity. The experimental results demonstrate that the SecMAS system achieves stable, efficient and secure data collection with lightweight quick-response network control.

Calorimetric determination of enthalpy changes for the proton ionization of 3-[N-morpholino]propanesulfonic acid (MOPS), 4-[N-morpholino]butanesulfonic acid (MOBS) and 3-[N-morpholino]-2-hydroxypropanesulfonic acid (MOPSO) in water-methanol mixtures

International Nuclear Information System (INIS)

Jumean, F.H.; Abdo, N.M.; Khamis, M.I.

2011-01-01

Highlights: → Two-stage proton ionizations for three N-substituted sulfonic acid derivatives of morpholine. → ΔH 1 and ΔH 2 in x methanol = 0-0.360 measured for MOPS, MOBS and MOPSO. → In water, ΔH 1 = ±1.2 kJ mol -1 , ΔH 2 range 20.7-26.3 kJ mol -1 . → Methanol addition had little effect on ΔH 1 but ΔH 2 rose steadily to 32.2 kJ mol -1 . → Results related to molecular and solvent parameters. - Abstract: Proton ionization enthalpies for three structurally related biological buffers, each with two ionizable protons, were determined using solution calorimetry. These buffers are 3-[N-morpholino]propanesulfonic acid (MOPS), 4-[N-morpholino]butanesulfonic acid (MOBS) and 3-[N-morpholino]-2-hydroxypropanesulfonic acid (MOPSO). Enthalpies were obtained in water-methanol mixtures with methanol mole fraction (X m ) from 0 to 0.360. The first ionization enthalpy (ΔH 1 ) of all buffers was small (±1.2 kJ mol -1 ) at all solvent compositions. The second ionization enthalpy (ΔH 2 ) increased steadily with X m , rising from 20.7 to 25.6 kJ mol -1 for MOPS, 26.3-31.0 kJ mol -1 for MOBS and 23.5-32.2 kJ mol -1 for MOPSO. The results were compared to those for related biological buffers. The observed variations were interpreted in terms of solvent-solvent and solvent-solute interactions.

Studies of DNA and chromosome damage in skin fibroblasts and blood lymphocytes from psoriasis patients treated with 8-methoxypsoralen and UVA irradiation

International Nuclear Information System (INIS)

Bredberg, A.; Lambert, B.; Lindblad, A.; Swanbeck, G.; Wennersten, G.

1983-01-01

Exposure of human lymphocytes and skin fibroblasts in vitro to a single, clinically used dose of PUVA, i.e., 0.1 micrograms/ml of 8-methoxypsoralen (8-MOP) plus 0.9-4 J/cm2 of longwave ultraviolet radiation (UVA), lead to the formation of DNA damage as determined by alkaline elution, and to chromosome aberrations and sister chromatid exchanges (SCE). When lymphocyte-enriched plasma was obtained from psoriasis patients 2 h after oral intake of 8-MOP and then UVA irradiated (1.8-3.6 J/cm2) in vitro, an increased frequency of chromosome aberrations and SCE was observed. Normal levels of chromosome aberrations and SCE were found in lymphocytes of psoriasis patients after 3-30 weeks of PUVA treatment in vivo. A small but statistically significant increase in the SCE frequency was observed in the lymphocytes of psoriasis patients treated for 1-6 years with PUVA (mean 18.0 SCE/cell) as compared with before PUVA (mean 15.8, p less than 0.05). Skin fibroblasts of psoriasis patients analyzed 5 years after the start of PUVA treatment showed a normal number of SCE but a high fraction of filter-retained DNA in the alkaline elution assay, suggesting the presence of cross-linked DNA

Mutation spectrum produced on PBR322 by 8-Methoxypsoralen plus UV-A light

International Nuclear Information System (INIS)

Bauluz, C.; Vidania, R.

1990-01-01

The mutagenic effect of 8-MOP+UVA (PUVA treatment) on pBR322 has been analysed by determining the frequency of mutation in the tet gene and identifying the type and position of the mutations produced inside a 276 pb-fragment (Bam-H1-SalI) of the same gene. pBR322 DNA was irradiated with UVA light in the presence of increasing concentrations of 8-Methoxypsoralen (8-MOP). The number of psoralen adducts formed in pBR322 upon that treatment ranged from 0 to 10.7 adducts per plasmid molecule. Modified DNA samples were used to transform several strains of E. Coli (differing in their repair capacities), both in constitutive conditions and after sos pre-induction by 254 nm-irradiation of cells. Mutation frequencies in the tet gene showed to increase in the wild type and uvrA strains along with the number of psoralen adducts per plasmid molecule; higher mutation frequencies were found in cells that had been previously irradiated to induce the SOS expression. Mutant plasmids were isolated from ApRTcS colonies and sequenced by the method of Maxam and Gilbert. Mutations appeared to be unique in most of the cases and were always punctual, i.e. affecting only to one base pair. The relative positions of the mutations showed a high frequency of coincidence among the sequenced fragments, indicating the existence of several DNA regions with high probability to mutated ('hot spots'). (author)

Demo 8. Ondas transversales con un muelle gigante

OpenAIRE

Ferrer Roca, Chantal; Zúñiga Román, Juan

2013-01-01

Objetivos. A. Diferencia entre pulso y onda sinusoidal. Velocidad de propagación de un pulso en función de la tensión. B. Interferencia de pulsos (constructiva y destructiva) C. ondas estacionarias (modos de una cuerda) con posibilidades de medida cuantitativa de la velocidad de propagación. Distintas longitudes y tensiones.

HUBUNGAN ANTARA PERTUMBUHAN DENGAN KEBERADAAN GEN TAHAN PENYAKIT MAJOR HISTOCOMPATIBILITY COMPLEX (MHC PADA IKAN MAS (Cyprinus carpio

Directory of Open Access Journals (Sweden)

Erma Primanita Hayuningtyas

2016-04-01

Full Text Available Wabah penyakit koi herpes virus (KHV di Indonesia yang terjadi sejak tahun 2002 merupakan salah satu faktor yang memicu kemerosotan produksi ikan mas budidaya. Pembentukan strain unggul ikan mas tahan KHV dapat menjadi solusi bagi permasalahan tersebut. Pemilihan genotip ikan mas tahan KHV dengan marka molekuler gen major histocompatibility complex class II (MHC-II, khususnya pada alel Cyca DAB 1*05 akan membantu dalam kegiatan seleksi. Penelitian ini bertujuan untuk mengetahui keberadaan gen MHC-II pada populasi dasar G0 ikan mas strain Rajadanu dan hubungannya dengan pertumbuhan (bobot. Metode deteksi keberadaan gen MHC-II pada dua kelompok ikan dengan ukuran berbeda dilakukan dengan teknik PCR. Hubungan antara pertumbuhan ikan mas dengan persentase kemunculan gen MHC-II dianalisis dengan menggunakan program SPSS (Statistical Package for the Social Sciences, sehingga diperoleh korelasi di antara keduanya. Hasil penelitian menunjukkan bahwa hubungan antara pertumbuhan dengan persentase keberadaan gen MHC-II berkorelasi negatif dengan nilai R = -0,742. Hal ini mengindikasikan bahwa semakin cepat pertumbuhan populasi ikan mas maka semakin sedikit persentase individu yang mempunyai gen MHC-II pada setiap populasi ikan mas. Sehingga populasi ikan mas yang pertumbuhannya lambat memiliki tingkat persentase positif MHC-II lebih tinggi (85,71%-100% dibandingkan populasi ikan mas yang pertumbuhannya cepat (42,86%-85,71%.

Induction and removal of DNA interstrand cross-links in V-79 Chinese hamster cells measured by hydroxylapatite chromatography after treatments with bifunctional furocoumarins

International Nuclear Information System (INIS)

Dardalhon, M.; Averbeck, D.

1988-01-01

DNA interstrand crosslinks (CL) photoinduced by bifunctional furocoumarins in V-79 Chinese hamster cells were measured by alkaline denaturation and hydroxylapatite chromatography. Treatments with 5-methoxypsoralen (5-MOP), 8-methoxypsoralen (8-MOP) and 4,5',8-trimethylpsoralen (4,5',8-TMP) and 365 nm irradiation (UVA) confer a dose-dependent linear increase in the amount of double-stranded DNA indicating the induction of CL. Determination in alkaline sucrose gradients of the molecular weight of the DNA and estimation of drug-induced strand breakage allowed quantification of the CL induced. 5-MOP was found to be slightly more effective than 8-MOP whereas 4,5',8-TMP was 9 times more effective for the induction of CL. The fate of CL during post-treatment incubation was also followed. Cells in exponential growth phase were found to be efficient in the removal of CL. (Author)

EVALUACIÓN DE LA DINÁMICA CARDIACA DE PACIENTES CON ARRITMIA CON BASE EN LA TEORÍA DE LA PROBABILIDAD

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Javier Rodríguez

2012-01-01

Full Text Available Teorías físicas y matemáticas como los siste-mas dinámicos y la teoría de la probabilidad han servido como base para el desarrollo de metodo-logías diagnósticas en medicina. En este trabajo se aplicaron parámetros de evaluación asociados al número de latidos por hora, establecidos en un trabajo diagnóstico previo, a Holter de 16 pacientes con diferentes arritmias cardiacas, 3 con indicaciones de sintomatologías o patologías previas diagnos-ticados como normales y 1 normal, con edades mayores a 21 años, para estudiar la respuesta de estos parámetros a esta patología específica. Se calculó la probabilidad del número total de latidos por hora en rangos de 250 latidos/hora, evaluando la presencia de una probabilidad máxima menor a 0,217 o mayor a 0,304 y la aparición de un número menor a 3,000 o mayor a 6,250 latidos/ hora, encontrando que 12 de los holter con arritmia presentaron como mínimo una de las dos condicio-nes mencionadas, del mismo modo que los holter con antecedentes de sintomatologías o patologías previas y con diagnóstico dentro de los límites de normalidad, mientras que el holter de normalidad no presentó ninguna de estas condiciones.Los parámetros evaluados asociados a la probabilidad del número de latidos caracterizan objetivamente la dinámica cardiaca y sugieren una posible utilidad para la detección de alteraciones leves o en evolución hacia la enfermedad, siendo necesarios estudios posteriores para definir su aplicación clínica en arritmias.

Factores de riesgo asociados con la prevalencia de hipertensión arterial en adultos de Bucaramanga, Colombia

Directory of Open Access Journals (Sweden)

Bautista Leonelo E

2002-01-01

Full Text Available Objetivo. Cuantificar la prevalencia de hipertensión arterial y su asociación con edad, sexo, estrato socioeconómico e índice de masa corporal. Material y métodos. Encuesta transversal, de base poblacional, hecha en 1996, en una muestra aleatoria de 356 adultos superscript three 20 años de edad, residentes en Bucaramanga, Colombia, en quienes se midieron peso, talla y presión arterial y se consideraron edad y sexo. Se usaron regresión lineal robusta y regresión binomial para estimar el efecto independiente de distintas variables sobre presión sistólica (PS, presión diastólica (PD e hipertensión arterial (HTA. Resultados. Las medias de PS y PD fueron significativamente mayores en hombres (122.5 y 88.1 mmHg que en mujeres (117.2 y 75.4 mmHg. La PS ajustada aumentó con la edad, mas en hombres que en mujeres, la PD no cambió significativamente con la edad. Por cada aumento de un kg/m² la PS y la PD aumentaron 0.76 y 0.69 mmHg, respectivamente. Participantes de estrato socioeconómico bajo tuvieron una PS 6.8 y una PD 9.8 mmHg mayor que los del nivel alto. La prevalencia ajustada de HTA (PHTA aumentó con la edad siendo mayor en los superscript three50 años que en los de 20 a 30. El sexo no tuvo efecto sobre la PHTA (p=0.795. Por cada aumento de un kg/m² la PHTA aumentó 3% y las personas del estrato socioeconómico bajo tuvieron una PHTA 1.84 veces mayor que las del alto. Conclusiones. La PHTA fue alta. Existe gran potencial para la prevención controlando el sobrepeso y la obesidad. Es necesario corroborar con nuevos estudios el aumento de la prevalencia en el estrato socioeconómico bajo e identificar sus causas.

Diseño de un prototipo para el ensayo de domóticas con tecnología EIB

OpenAIRE

Giménez Sánchez, Miguel Ángel

2009-01-01

[ESP]Actualmente la domótica esta experimentando un gran desarrollo y se está introduciendo cada vez mas en la vida cotidiana, y su proyección es indudable. Por lo tanto su estudio y comprensión es cada día más importante. Con este proyecto se pretende obtener una herramienta útil para el estudio de una instalación domótica bajo el sistema EIB-KNX, mediante un prototipo de instalación con el que se podrá interactuar y realizar todas las conexiones y programaciones necesarias. La idea es re...

Nanoparticulas basadas en complejos de Fe(II) con transicion de espin: sintesis, caracterizacion y aplicaciones en electronica molecular

Science.gov (United States)

Monrabal Capilla, Maria

Esta tesis doctoral esta organizada en 5 capitulos y esta destinada al estudio de sistemas de Fe (II) que presentan el fenomeno de la transicion de espin a escala nanometrica. El capitulo 1 contiene una introduccion general sobre materiales moleculares multifuncionales, destacando aquellos ejemplos mas importantes. Por otro lado, se explicara el fenomeno de la transicion de espin, tratando aspectos conceptuales, los antecedentes mas importantes y la situacion actual. En el capitulo 2 se describen los diferentes procesos existentes para la obtencion de diferentes tipos de nanoparticulas. Ademas, se presenta la sintesis y caracterizacion de nanoparticulas del polimero de coordinacion unidimensional [Fe(Htrz)2(trz)]BF4, obtenidas mediante el metodo de micelas inversas. Estas nanoparticulas, con una estrecha distribucion de tamanos centrada alrededor de los 11 nm, presentan una transicion de espin muy abrupta, con un ancho ciclo de histeresis termica de unos 40K. En el capitulo 3 se describe el proceso de modificacion del tamano de las nanoparticulas descritas en el capitulo anterior, llevado a cabo variando la proporcion de surfactante/H2O en el medio. Ademas, con el objetivo de modificar las propiedades magneticas de las nanoparticulas obtenidas en el capitulo 2, se lleva a cabo la sintesis de nanoparticulas de polimeros de la misma familia del [Fe(Htrz)2(trz)]BF4. En concreto se sintetizaron 3 nuevos tipos de nanoparticulas basadas en el polimero [Fe(Htrz)1-x(NH2trz)x](ClO4)2, siendo x = 0.05, 0.15 y 0.3, en cada caso. Estas nanoparticulas siguen presentando una estrecha distribucion de tamanos y una transicion de espin muy abrupta y con un ancho ciclo de histeresis. Ademas, se observa que este ciclo se desplaza a temperaturas mas proximas a la temperatura ambiente a medida que se aumenta el porcentaje de 4-amino-1, 2, 4- triazol en la muestra. Pero al mismo tiempo se produce una disminucion de la anchura de este ciclo. Por ultimo, en este capitulo se presenta la

De masonería, control y otras lealtades fraternales: el rescate de Porfirio Díaz por un hermano masón

Directory of Open Access Journals (Sweden)

Guillermo de los Reyes Heredia

2015-01-01

Full Text Available En este artículo se explora el papel que jugó Porfirio Díaz dentro de la masonería y su relación con dichainstitución. Se analiza una de las historias que comprueban que Díaz logró ciertos beneficios gracias a suafiliación masónica desde antes que fuera presidente de México. Esta historia narra la manera en que Díazlogró entrar de contrabando a México con la ayuda de un hermano masón en 1876, después de su breve exilioen Nuevo Orleans a bordo del buque de vapor, “City of Havana”. En un principio se pensaba que ésta erasimplemente una leyenda más del folklore que envuelve a la masonería. Sin embargo, dos testimonios, ambosde masones que iban en el mismo barco ratifican la historia que incluso el mismo historiador de la masoneríanorteamericana, William Deslow, catalogaba como un incidente, “no verificado.”Asimismo, se describe cómo Díaz promovió la unificación de las logias del rito escocés en unainstitución que se llamó La Gran Dieta Simbólica. La razón principal por la cual Díaz promovió talunificación, como se afirma en este artículo, fue para llevar a cabo su plan de pacificación nacional. Díazsabía que tenía que obtener el control de la masonería para evitar que ésta le causara problemas para lograr elorden y progreso que caracterizó a su gobierno. Por tal motivo, el dictador siempre vigiló que ni la masonería,ni cualquier otra institución que hubiera podido tener cierta influencia en la sociedad estuvieran fuera de sucontrol.

Estudio y análisis de instalaciones de centrales termosolares con tecnología CCP

OpenAIRE

MAS SANZ, JAVIER

2011-01-01

Trabajo científico técnico. El presente proyecto, trata de realizar el análisis y estudio de las plantas de generación de energía limpia y renovable, basadas en tecnología desarrollada a partir de captadores cilindro parabólicos Mas Sanz, J. (2011). Estudio y análisis de instalaciones de centrales termosolares con tecnología CCP. http://hdl.handle.net/10251/12088. Archivo delegado

Psoralen plus ultraviolet radiation-induced inhibition of DNA synthesis and viability in human lymphoid cells in vitro

Energy Technology Data Exchange (ETDEWEB)

Kraemer, K H; Waters, H L [National Cancer Inst., Bethesda, MD (USA); Ellingson, O L; Tarone, R E

1979-08-01

The present study investigated whether conditions of 8-methoxypsoralen (8-MOP) concentration and of exposure to high intensity long wavelength ultraviolet radiation (UV-A) during psoriasis and mycosis fungoides therapy might be sufficient to result directly in decreased lymphoid cell DNA synthesis and viability in vitro. Tritiated thymidine (/sup 3/HtdR) incorporation and cell growth following UV-A exposure alone or with 8-MOP was examined in peripheral blood lymphocytes and in Ebstein-Barr virus transformed human lymphoblastoid cell lines. UV-A exposure alone induced a dose-dependent inhibition of /sup 3/HTdR incorporation in both types of lymphoid cells. Pre-incubation with 0.1 ..mu..g/ml 8-MOP before UV-A exposure induced a significantly greater inhibition of /sup 3/HTdr incorporation. Further inhibition of /sup 3/HTdR incorporation was observed by preincubation of the lymphoblastoid cells with 1.0 ..mu..g/ml 8-MOP but not in the lymphocytes. The concentration of viable lymphoblastoid cells did not decrease below the original concentration after the highest dose of UV-A alone (29,00 J/m/sup 2/) but preincubation with 0.1 ..mu..g/ml 8-MOP resulted in 40% and 0.6% survival respectively after 3000 J/m/sup 2/. This study suggested that the low doses of 8-MOP and UV-A received by patients' lymphocytes may be sufficient to explain the decreased DNA synthesis found in their circulating leucocytes. (author).

MAS Integration and Controllership Effectiveness: Evidence of a Preparer-User Perception Gap

OpenAIRE

Weißenberger, Barbara E.; Angelkort, Hendrik; Holthoff, Gero

2012-01-01

Recent evidence suggests that managers establish a positive link between management accounting system (MAS) integration and controllership effectiveness, which is fully mediated by the perceived consistency of financial language. Our paper extends this research by analyzing whether controllers have similar perceptions on MAS design. Testing a series of multi-group structural equation models, we find evidence for a preparer-user perception gap with respect to the mediating impact of a consiste...

Improved background suppression in 1H MAS NMR using composite pulses

Science.gov (United States)

Odedra, Smita; Wimperis, Stephen

2012-08-01

A well known feature of 1H MAS NMR spectroscopy, particularly of solids where the concentration of 1H nuclei is low, is the presence in the spectrum of a significant broad "background" signal arising from 1H nuclei that are outside the MAS rotor and radiofrequency coil, probably located on the surfaces of the static components of the probehead. A popular method of suppressing this unwanted signal is the "depth pulse" method, consisting of a 90° pulse followed by one or two 180° pulses that are phase cycled according to the "Exorcycle" scheme, which removes signal associated with imperfect 180° pulses. Consequently, only spins in the centre of the radiofrequency coil contribute to the 1H MAS spectrum, while those experiencing a low B1 field outside the coil are suppressed. Although very effective at removing background signal from the spectrum, one drawback with this approach is that significant loss of the desired signal from the sample also occurs. Here we investigate the 1H background suppression problem and, in particular, the use of novel antisymmetric passband composite pulses to replace the simple pulses in a depth pulse experiment. We show that it is possible to improve the intensity of the 1H signals of interest while still maintaining effective background suppression. We expect that these results will be relevant to 1H MAS NMR studies of, for example, nominally perdeuterated biological samples or nominally anhydrous inorganic materials.

Prevalencia de Caries Dental en una Comunidad Escolar de la Etnia Wayúu, en la Guajira Colombiana y su Manejo con Medicina Ancestral.

Directory of Open Access Journals (Sweden)

Hector Ángel Polanco Narvaéz

2012-03-01

Full Text Available Objetivo: Establecer la prevalencia de caries dental y su manejo terapéutico tradicional en la población indígena wayuu de la Guajira colombiana. Materiales y métodos: Se realizó un examen oral a 245 niños en edad escolar que asisten a la concentración escolar Camino Verde del Municipio de Manaure en la Guajira Colombiana; mediante entrevistas semiestructuradas con la población, se hizo reconocimiento de las plantas que son utilizadas para tratar los problemas de salud oral. Se analizo e interpretó el concepto de la salud bucal, en una comunidad que resalta la importancia del equilibrio con la naturaleza; los recursos que utilizan para preservar una adecuada higiene oral, la interacción de la naturaleza con su cuerpo para mantener un equilibrio con la vida. Resultados: Los indices Ceo-d y CPO-D en comparacion con el estudio del ENSAB III, mostraron un aumento de la prevalencia de caries; solo los niños de 5 años presentan  un promedio de caries mas bajo en comparacion con los resultados de este estudio. De otra parte, el tratamiento y prevencion de las patologias de cavidad oral siguen siendo tratadas bajo la medicina tradicional indigena, aunque la medicina occidental ya hace parte de la terapeutica de la poblacion. Conclusiones: Los resultados sugieren trabajar mas en la promocion de la salud oral, para asi bajar los indices de caries; Por otro lado, La medicina tradicional indigena aunque importante, no refleja sus efectos, ademas de observar que la medicina occidental ha tenido gran acogida y cada vez su uso es mayor.

Food Waste Composting Study from Makanan Ringan Mas

Science.gov (United States)

Kadir, A. A.; Ismail, S. N. M.; Jamaludin, S. N.

2016-07-01

The poor management of municipal solid waste in Malaysia has worsened over the years especially on food waste. Food waste represents almost 60% of the total municipal solid waste disposed in the landfill. Composting is one of low cost alternative method to dispose the food waste. This study is conducted to compost the food waste generation in Makanan Ringan Mas, which is a medium scale industry in Parit Kuari Darat due to the lack knowledge and exposure of food waste recycling practice. The aim of this study is to identify the physical and chemical parameters of composting food waste from Makanan Ringan Mas. The physical parameters were tested for temperature and pH value and the chemical parameter are Nitrogen, Phosphorus and Potassium. In this study, backyard composting was conducted with 6 reactors. Tapioca peel was used as fermentation liquid and soil and coconut grated were used as the fermentation bed. Backyard composting was conducted with six reactors. The overall results from the study showed that the temperature of the reactors were within the range which are from 30° to 50°C. The result of this study revealed that all the reactors which contain processed food waste tend to produce pH value within the range of 5 to 6 which can be categorized as slightly acidic. Meanwhile, the reactors which contained raw food waste tend to produce pH value within the range of 7 to 8 which can be categorized as neutral. The highest NPK obtained is from Reactor B that process only raw food waste. The average value of Nitrogen is 48540 mg/L, Phosphorus is 410 mg/L and Potassium is 1550 mg/L. From the comparison with common chemical fertilizer, it shows that NPK value from the composting are much lower than NPK of the common chemical fertilizer. However, comparison with NPK of organic fertilizer shown only slightly difference value in NPK.

Association of sequences in the coat protein/readthrough domain of potato mop-top virus with transmission by Spongospora subterranea.

Science.gov (United States)

Reavy, B; Arif, M; Cowan, G H; Torrance, L

1998-10-01

A monofungal culture of Spongospora subterranea was unable to acquire and transmit the T isolate of potato mop-top pomovirus (PMTV-T), which has been maintained by manual transmission in the laboratory for 30 years. A recently obtained field isolate (PMTV-S) was efficiently acquired and transmitted by the same fungus culture. Sequence analysis of the readthrough (RT) protein-coding region of PMTV-S showed the presence of an additional 543 nt in the 3' half of the coding region relative to that of PMTV-T. These additional nucleotides preserved the reading frame of the RT protein and inserted 181 amino acids into the RT protein. This was confirmed by a comparison by immunoblotting of the sizes of the RT protein of PMTV-T and other recent isolates of PMTV.

Paciente con esquizofrenia tratado con ziprasidona + clozapina

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Pol Yanguas E.

2013-05-01

Full Text Available P es un paciente diagnosticado de esquizofrenia, sigue en un piso tutelado un programa de rehabilitación, está medicado con clozapina 500 mg/día y ziprasidona 280 mg/ día. Padece hipercolesterolemia, tabaquismo y sus hábitos alimenticios no son buenos. La medicación que utiliza desde 2007 hasta ahora se refleja en la tabla 1. El último tratamiento se le introdujo el 7 de agosto de 2012, habiendo presentado un electro cardiograma (ECG normal, pero con ligera taquicardia ventricular y prolactinemia de 44,8 ng/ml (valores normales: 2-18 ng/ml.

Extremely high magnetoresistance and conductivity in the type-II Weyl semimetals WP2 and MoP2.

Science.gov (United States)

Kumar, Nitesh; Sun, Yan; Xu, Nan; Manna, Kaustuv; Yao, Mengyu; Süss, Vicky; Leermakers, Inge; Young, Olga; Förster, Tobias; Schmidt, Marcus; Borrmann, Horst; Yan, Binghai; Zeitler, Uli; Shi, Ming; Felser, Claudia; Shekhar, Chandra

2017-11-21

The peculiar band structure of semimetals exhibiting Dirac and Weyl crossings can lead to spectacular electronic properties such as large mobilities accompanied by extremely high magnetoresistance. In particular, two closely neighboring Weyl points of the same chirality are protected from annihilation by structural distortions or defects, thereby significantly reducing the scattering probability between them. Here we present the electronic properties of the transition metal diphosphides, WP 2 and MoP 2 , which are type-II Weyl semimetals with robust Weyl points by transport, angle resolved photoemission spectroscopy and first principles calculations. Our single crystals of WP 2 display an extremely low residual low-temperature resistivity of 3 nΩ cm accompanied by an enormous and highly anisotropic magnetoresistance above 200 million % at 63 T and 2.5 K. We observe a large suppression of charge carrier backscattering in WP 2 from transport measurements. These properties are likely a consequence of the novel Weyl fermions expressed in this compound.

A Bio-Economic Case Study of Canadian Honey Bee (Hymenoptera: Apidae) Colonies: Marker-Assisted Selection (MAS) in Queen Breeding Affects Beekeeper Profits

Science.gov (United States)

Baylis, Kathy; Hoover, Shelley E.; Currie, Rob W.; Melathopoulos, Andony P.; Pernal, Stephen F.; Foster, Leonard J.; Guarna, M. Marta

2017-01-01

Abstract Over the past decade in North America and Europe, winter losses of honey bee (Hymenoptera: Apidae) colonies have increased dramatically. Scientific consensus attributes these losses to multifactorial causes including altered parasite and pathogen profiles, lack of proper nutrition due to agricultural monocultures, exposure to pesticides, management, and weather. One method to reduce colony loss and increase productivity is through selective breeding of queens to produce disease-, pathogen-, and mite-resistant stock. Historically, the only method for identifying desirable traits in honey bees to improve breeding was through observation of bee behavior. A team of Canadian scientists have recently identified markers in bee antennae that correspond to behavioral traits in bees and can be tested for in a laboratory. These scientists have demonstrated that this marker-assisted selection (MAS) can be used to produce hygienic, pathogen-resistant honey bee colonies. Based on this research, we present a beekeeping case study where a beekeeper’s profit function is used to evaluate the economic impact of adopting colonies selected for hygienic behavior using MAS into an apiary. Our results show a net profit gain from an MAS colony of between 2% and 5% when Varroa mites are effectively treated. In the case of ineffective treatment, MAS generates a net profit benefit of between 9% and 96% depending on the Varroa load. When a Varroa mite population has developed some treatment resistance, we show that MAS colonies generate a net profit gain of between 8% and 112% depending on the Varroa load and degree of treatment resistance. PMID:28334400

Improved background suppression in ¹H MAS NMR using composite pulses.

Science.gov (United States)

Odedra, Smita; Wimperis, Stephen

2012-08-01

A well known feature of ¹H MAS NMR spectroscopy, particularly of solids where the concentration of ¹H nuclei is low, is the presence in the spectrum of a significant broad "background" signal arising from ¹H nuclei that are outside the MAS rotor and radiofrequency coil, probably located on the surfaces of the static components of the probehead. A popular method of suppressing this unwanted signal is the "depth pulse" method, consisting of a 90° pulse followed by one or two 180° pulses that are phase cycled according to the "Exorcycle" scheme, which removes signal associated with imperfect 180° pulses. Consequently, only spins in the centre of the radiofrequency coil contribute to the ¹H MAS spectrum, while those experiencing a low B₁ field outside the coil are suppressed. Although very effective at removing background signal from the spectrum, one drawback with this approach is that significant loss of the desired signal from the sample also occurs. Here we investigate the ¹H background suppression problem and, in particular, the use of novel antisymmetric passband composite pulses to replace the simple pulses in a depth pulse experiment. We show that it is possible to improve the intensity of the ¹H signals of interest while still maintaining effective background suppression. We expect that these results will be relevant to ¹H MAS NMR studies of, for example, nominally perdeuterated biological samples or nominally anhydrous inorganic materials. Copyright © 2012 Elsevier Inc. All rights reserved.

Patrones de distribución de anémonas de mar chilenas de aguas someras (cnidaria: anthozoa: actiniaria, corallimorpharia); con una discusión de las relaciones taxonómicas y zoogeográficas de la actinofauna del Pacífico sudoriental, el Atlántico sudoccidental y la Antártida

OpenAIRE

Häussermann, Verena; Försterra, Günter

2005-01-01

La presente publicación provee un primer análisis zoogeográfico completo de las anémonas de mar (Actiniaria y Corallimorpharia) de las aguas someras a lo largo de la costa chilena y de sus relaciones con faunas vecinas, basando en un extenso muestreo en los últimos años en combinación con revisiones de la literatura. Desde 1994 hasta 2004 obtuvimos mas de 1000 ejemplares pertenecientes a 32 especies de Actiniaria y Corallimorpharia. Se muestrearon mas de 100 lugares enclavados en el intermare...

Elektroniskās naudas sistēmas WebMoney

OpenAIRE

Zablocka, Jelena

2011-01-01

Šī darba mērķis ir pamatojoties uz speciālo literatūru un pieejamu statistisko informāciju izskatīt jautājumu par elektroniskās naudas būtību, raksturot un parādīt tās veidus, analizēt un izskatīt elektroniskās naudas izmantošanas problēmas, izpētīt un norādīt tās izmantošanas perspektīvas, novērtēt tās uzskaites un kontroles operāciju problēmas, kas ir sastopamas, izmantojot elektronisko naudu praksē. Darbs sastāv no 5 nodaļām. Pirmajā nodaļā aplūkoti elektroniskās naudas jēdziens un ...

Genetical control of mitotic crossing over in yeast

International Nuclear Information System (INIS)

Fedorova, I.V.; Marfin, A.B.

1982-01-01

Lethal effect of 8 methoxypsoralen (8-MOP) and long-wave ultraviolet radiation (LUR) on diploid and haploid radiosensitive strains of yeast LSaccharomyces cerevisiae has been studied. It is shown that wild type diploids and homozygous with respect to locus rad 2 is considerably more stable than corresponding haploids, while diploid homozygous with respect to rad 54 locus is more sensitive than haploid. Use of the method of repeated irradiation permitted to study capability of radiosensitive diploids to remove 8 MOP-induced DNA photodamages-monoadducts. This process proceeds effectively in the wild type strain and rad 54 rad 54 diploid and was absent in rad 2 rad 2 diploid. Very strong recombinogenous effect of 8-MOP and LUR was discovered when studying mitotic segregation and crossing-over. It is also shown that rad 2 mutation increases slightly and rad 54 mutation decreases sharply frequency of recombination events in yeast cells. It is established by means of the repeated irradiation method that the main contribution to the 8 MOP and LUR recombinogenous effect is made with DNA sutures induced with these agents. Possible participation of different repair systems in the recombination processes induced with 8 MOP and LUR in yeast cells is discussed

Towards a distributed electric generation scheme with non-conventional energies; Hacia un esquema de generacion electrica distribuida con energias no convencionales

Energy Technology Data Exchange (ETDEWEB)

Huacuz Villamar, Jorge M. [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

1997-12-31

Several factors contributed to the existence of large electric systems as we know them today, such as: the increase of the electric demand by the advancement of the industrial development, the appearance of electric equipment, and household devices and by the advancement in the engineering systems, just to mention a few of them. With all this, the third part of the World population still does not have access to the electricity service. The efforts that the small electric enterprises perform to carry the service up to the site where it is required, every day time becomes more expensive and less effective. Exhausted by the weight of a huge economic debt, many electric utilities of the developing countries find each time more difficult to obtain financing to extend the power lines. This situation becomes still more serious with the present privatization scheme of the electric utilities. Although new technologies are being developed to counteract the negative effects caused by the large electricity generation power plants, the society seems to begin to show preferences for more benign to the environment options. The scheme of distributed generation can be given in to modalities: By means of isolated systems in remote sites, where there is not access to the conventional services; and with systems interconnected with the electric network where this is available [Espanol] Varios factores contribuyeron a la aparicion de los grandes sistemas electricos como los conocemos hoy en dia, tales como: el crecimiento de la demanda electrica por el avance del desarrollo industrial, la aparicion de equipos electricos y aparatos electrodomesticos y por avances en la ingenieria de los sistemas, por mencionar algunos. Con todo ello, la tercera parte de la poblacion mundial no tiene aun acceso al servicio electrico. Los esfuerzos que realizan las companias electricas para llevar el servicio hasta donde se requiere, resultan cada vez mas costosos y menos efectivos. Agobiadas por el peso

Escala de atitudes frente ao dinheiro (MAS: Teste de modelos e poder preditivo

Directory of Open Access Journals (Sweden)

Carlos Eduardo Pimentel

2012-01-01

Full Text Available The social importance attached to money and its role as an important motivator of behavior justifies the study of its psychosocial aspects. But there is a lack of studies concerning attitudinal or psychological aspects of money in Brazil. In order to encourage research in this context, the validity of the Money Attitudes Scale (MAS was tested using confirmatory factor approaches. Results supported a brief 16-items version of the scale and replicated the factor analytic pattern with satisfactory internal consistency for the factors of power, retention, distrust, and anxiety. Age differences were observed regarding money attitudes of power, and the predictive role of the MAS to account for consumer behavior was also confirmed. This version of the MAS shows evidences of factorial validity and reliability, justifying its use in future research.

High Tech M&As

DEFF Research Database (Denmark)

Toppenberg, Gustav

2013-01-01

Technology driven industries have seen fast moving technology changes, higher complexity and reduced product life cycles. These emerging trends present challenges for companies in industries where technology is at the forefront. The extant research deals with ‘low-tech’ industries and majority...... of findings are not applicable to the high-tech industry; in fact this industry has many additional challenges. In this study, we aim to explore the process of M&A in the high-tech industry by drawing on extant literature and empirical field work. The paper outlines a research project in progress which...... intends to provide theoretical, empirical and practical contributions in answering the research question: what role does Operations and IT play in creating value in high-tech M&As? The research adds a needed perspective on M&A literature by unveiling unique challenges and opportunities faced by the M...

CAMEX-4 ER-2 MODIS AIRBORNE SIMULATOR (MAS) V1

Data.gov (United States)

National Aeronautics and Space Administration — The MODIS Airborne Simulator (MAS) is an airborne scanning spectrometer that acquires high spatial resolution imagery of cloud and surface features from its vantage...

Role of Mas Receptor Antagonist A799 in Renal Blood Flow Response to Ang 1-7 after Bradykinin Administration in Ovariectomized Estradiol-Treated Rats

Directory of Open Access Journals (Sweden)

Aghdas Dehghani

2015-01-01

Full Text Available Background. The accompanied role of Mas receptor (MasR, bradykinin (BK, and female sex hormone on renal blood flow (RBF response to angiotensin 1-7 is not well defined. We investigated the role of MasR antagonist (A779 and BK on RBF response to Ang 1-7 infusion in ovariectomized estradiol-treated rats. Methods. Ovariectomized Wistar rats received estradiol (OVE or vehicle (OV for two weeks. Catheterized animals were subjected to BK and A799 infusion and mean arterial pressure (MAP, RBF, and renal vascular resistance (RVR responses to Ang 1-7 (0, 100, and 300 ng kg−1 min−1 were determined. Results. Percentage change of RBF (%RBF in response to Ang1-7 infusion increased in a dose-dependent manner. In the presence of BK, when MasR was not blocked, %RBF response to Ang 1-7 in OVE group was greater than OV group significantly (P<0.05. Infusion of 300 ng kg−1 min−1 Ang 1-7 increased RBF by 6.9±1.9% in OVE group versus 0.9±1.8% in OV group. However when MasR was blocked, %RBF response to Ang 1-7 in OV group was greater than OVE group insignificantly. Conclusion. Coadministration of BK and A779 compared to BK alone increased RBF response to Ang 1-7 in vehicle treated rats. Such observation was not seen in estradiol treated rats.

TOKSISITAS LETAL MOLUSKISIDA NIKLOSAMIDA PADA BENIH IKAN MAS (Cyprinus carpio

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Yosmaniar Yosmaniar

2009-04-01

Full Text Available Penggunaan moluskisida untuk menanggulangi hama dalam budidaya tanaman padi yang semakin meningkat berpotensi mencemari lingkungan perairan, karena mengandung residu dari bahan aktifnya. Moluskisida niklosamida (C13H8Cl2N2O4 merupakan bahan aktif pestisida yang digunakan untuk memberantas hama keong mas atau siput murbei (Pomacea sp. di sawah. Dengan demikian, bahan tersebut memiliki potensi untuk mencemari lahan tempat usaha budidaya ikan. Penelitian ini bertujuan untuk mengetahui potensi toksisitas akut niklosamida terhadap benih ikan mas (Cyprinus carpio yang ditunjukkan oleh nilai Median Lethal Concentration (LC50 24, 48, dan 96 jam. Penelitian dilakukan di Instalasi Riset Lingkungan Perikanan Budidaya dan Toksikologi, Cibalagung-Bogor. Menggunakan ikan mas dengan bobot individu 2,47 ± 0,13 g. Moluskisida yang digunakan mengandung bahan aktif niklosamida 250g/L. Wadah pengujian berupa 21 unit akuarium kaca berukuran 40 cm x 20 cm x 20 cm yang dilengkapi aerasi serta saluran pemasukan dan pengeluaran. Jumlah ikan uji setiap wadah 10 ekor dengan peubah yang diukur adalah mortalitas ikan. Selama penelitian ikan tidak diberi makan. Tahapan penelitian terdiri atas penentuan nilai ambang atas-bawah, nilai lethal time dan LC50 -24, 48, 72, dan 96 jam. Data diolah dengan analisis probit program LC50. Hasil penelitian menunjukkan bahwa nilai LC50-24, 48, 72, dan 96 jam terhadap benih ikan mas adalah 0,8012 (0,7140—0,8990; 0,5999 (0,5356—0,6719; 0,4511 (0,4067—0,5004; dan 0,3849 mg/L (0,3684—0,4061. Hal ini menunjukkan niklosamida termasuk pestisida yang memiliki toksisitas sangat tinggi (golongan A. The use of molluscicide in aquatic as well as in terresterial agro ecosystem without properly controlled may produce detrimental effects on freshwater fisheries. Molluscicide utilization for golden apple snail (Pomacea sp. control in rice field has increased. The ingredient potencially has a possibility to pollute aquaculture water. The

Development of a generic, computerized nuclear material accountability system: NucMAS

International Nuclear Information System (INIS)

Cornell, M.D.; O'Leary, J.M.

1987-01-01

The application NucMAS provides basic computerized accountability functions for the Savannah River Plant (SRP) Separations Department Material Balance Areas (MBA's). These functions include data entry, data management, calculations, and report generation. NucMAS can be used both for routine reporting to the SRP central Material Control and Accounting (MC and A) system and for rapid ad hoc queries in emergency situations. The system is designed to work with any process handling one or more of the 17 accountable nuclear materials specified by the Department of Energy (DOE). It relies on user-supplied configuration data to drive data prompts, report headings, data validations, and calculations

A Bio-Economic Case Study of Canadian Honey Bee (Hymenoptera: Apidae) Colonies: Marker-Assisted Selection (MAS) in Queen Breeding Affects Beekeeper Profits.

Science.gov (United States)

Bixby, Miriam; Baylis, Kathy; Hoover, Shelley E; Currie, Rob W; Melathopoulos, Andony P; Pernal, Stephen F; Foster, Leonard J; Guarna, M Marta

2017-06-01

Over the past decade in North America and Europe, winter losses of honey bee (Hymenoptera: Apidae) colonies have increased dramatically. Scientific consensus attributes these losses to multifactorial causes including altered parasite and pathogen profiles, lack of proper nutrition due to agricultural monocultures, exposure to pesticides, management, and weather. One method to reduce colony loss and increase productivity is through selective breeding of queens to produce disease-, pathogen-, and mite-resistant stock. Historically, the only method for identifying desirable traits in honey bees to improve breeding was through observation of bee behavior. A team of Canadian scientists have recently identified markers in bee antennae that correspond to behavioral traits in bees and can be tested for in a laboratory. These scientists have demonstrated that this marker-assisted selection (MAS) can be used to produce hygienic, pathogen-resistant honey bee colonies. Based on this research, we present a beekeeping case study where a beekeeper's profit function is used to evaluate the economic impact of adopting colonies selected for hygienic behavior using MAS into an apiary. Our results show a net profit gain from an MAS colony of between 2% and 5% when Varroa mites are effectively treated. In the case of ineffective treatment, MAS generates a net profit benefit of between 9% and 96% depending on the Varroa load. When a Varroa mite population has developed some treatment resistance, we show that MAS colonies generate a net profit gain of between 8% and 112% depending on the Varroa load and degree of treatment resistance. © The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America.

Linfomas asociados con la infección por el virus de la inmunodeficiencia humana: subtipos histológicos y asociación con los virus de Epstein Barr y Herpes-8 AIDS related lymphomas: Histopathological subtypes and association with Epstein Barr virus and Human Herpes virus type-8

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Marcelo Corti

2010-04-01

Full Text Available Los linfomas no Hodgkin (LNH constituyen la segunda neoplasia definitoria de Sida más frecuente. En el presente trabajo se evaluaron 48 casos de linfomas asociados con la enfermedad debida al virus de la inmunodeficiencia humana (HIV diagnosticados en la División Histopatología del Instituto de Investigaciones Hematológicas de la Academia Nacional de Medicina. Se incluyeron en la investigación 5 mujeres y 43 hombres con una mediana de edad al momento del diagnóstico de la neoplasia de 37 años. La evaluación morfológica se realizó en cortes coloreados con hematoxilina-eosina, estudio inmunohistoquímico para la detección del virus de Epstein Barr (VEB en 48/48 casos, y mediante sonda oligonucleotídica biotinilada para la detección del ADN del Herpes virus humano tipo-8 (HHV-8 en 14/14 linfomas plasmoblásticos (LP. Todos fueron linfomas de fenotipo B, con un curso clínico agresivo y enfermedad neoplásica avanzada al momento del diagnóstico. Se pudo demostrar la fuerte asociación del VEB con los linfomas asociados al sida, con frecuencias que variaron según el subtipo histológico: 16/21 (76% para los linfomas difusos de grandes células; 1/3 casos (33% de linfomas de Burkitt y 3/4 (75% en los linfomas primarios del sistema nervioso central. Globalmente, el genoma del VEB se detectó en 20/28 (71% de las muestras de biopsias de LNH de esta serie. La detección del HHV-8 resultó negativa en los 14 LP. Los linfomas de Hodgkin fueron más frecuentes en varones,18/20 (90%, con un curso clínico agresivo y franco predominio de los subtipos histológicos de peor pronóstico (90% de casos. En estas neoplasias también se comprobó una frecuente asociación patogénica con el VEB (90% de casos.Non-Hodgkin lymphomas (NHL of the B-cell type are the second most common neoplasm among patients with human immunodeficiency virus (HIV infection and AIDS. Here, we evaluated 48 cases of AIDS-related lymphomas (ARL diagnosed at the

Differential effects of treatment with UV-light (365 nm) and 8-methoxypsoralen on chromosomes of healthy persons and psoriatic patients

International Nuclear Information System (INIS)

Loeber, G.; Kittler, L.

1986-01-01

The effect of 8-methoxypsoralen (8-MOP, 5 x 10 -5 M), near UV-light of 365 nm wavelength (UVA, 1.5 J/cm 2 ) and the combination of both (PUVA treatment) were studied on lymphocytes in vitro taken from healthy persons and patients with psoriasis vulgaris and psoriasis arthritis (psoriasis arthropathica). Chromosomes isolated from cell nuclei were visualized by means of Giemsa staining technique and analyzed for induction of chromosomal defects, i.e. premature centromere division (PCD), major coiling (MC), and formation of gaps and fragile sites. Exposure of nonpsoriatic lymphocytes to 8-MOP, UVA or PUVA increased the rate of PCD or MC generation. In experiments with psoriatic lymphocytes a much weaker effect was found, with a moderate increase of PCD and MC after UVA or PUVA treatment in the case of psoriasis vulgaris, and of MC after UVA treatment of psoriasis arthritis. On the average the number of chromosomes per metaphase plate displaying PCD did not exceed 10. No indication was obtained for the preference of certain chromosome groups or the appearance of 'fragile sites'. Under all experimental conditions the number of chromosome gaps ranged in the order of their spontaneous induction. The findings suggest PCD and MC investigations as possible sensitive tools for diagnosing latent psoriasis and for refined analysis of psoriatic cells or chromosomes. (author)

Utilidad del Children's Embedded Figures Test en el Trastorno por Déficit de Atención con Hiperactividad

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José Antonio López Villalobos

2010-01-01

Full Text Available El estudio analiza diferencias entre casos de Trastorno por Déficit de Atención con Hiperactividad (TDAH y controles en su modo global / analítico de procesar la información, buscando el mejor modelo basado en el Children's Embedded Figures Test (CEFT que permita predecir TDAH y analizando la validez de la prueba para el diagnóstico del trastorno. Se estudia una muestra de 100 casos de TDAH (criterios DSM-IV y 100 controles, entre 7 y 11 años, evaluados mediante el CEFT. Los controles fueron reclutados de forma aleatoria y emparejados según edad, sexo y zona sociodemográfica con los casos. Los casos presentan un estilo cognitivo medio significativamente mas dependiente de campo (d = 1.36, reflejando un modo de procesamiento mas global que los controles en todas las edades. El modelo de regresión logística que mejor predice TDAH está formado por edad, sexo y CEFT. La formulación derivada del modelo presenta sensibilidad del 80% y especifidad del 84%, tomando como prueba de referencia criterios DSM-IV para TDAH. Concluimos valorando que el CEFT presenta utilidad y adecuada validez de criterio para TDAH.

Smoke, Clouds and Radiation Brazil NASA ER-2 Moderate Resolution Imaging Spectrometer (MODIS) Airborne Simulator (MAS) Data

Data.gov (United States)

National Aeronautics and Space Administration — SCARB_ER2_MAS data are Smoke, Clouds and Radiation Brazil (SCARB) NASA ER2 Moderate Resolution Imaging Spectrometer (MODIS) Airborne Simulator (MAS)...

Characterization and significance of ACE2 and Mas receptor in human colon adenocarcinoma.

Science.gov (United States)

Bernardi, Stella; Zennaro, Cristina; Palmisano, Silvia; Velkoska, Elena; Sabato, Nicoletta; Toffoli, Barbara; Giacomel, Greta; Buri, Luigi; Zanconati, Fabrizio; Bellini, Giuseppe; Burrell, Louise M; De Manzini, Nicolò; Fabris, Bruno

2012-03-01

A new arm of the renin-angiotensin system (RAS) has been recently characterized; this includes angiotensin converting enzyme (ACE)2 and angiotensin (Ang)1-7, a heptapeptide acting through the Mas receptor (MasR). Recent studies show that Ang1-7 has an antiproliferative action on lung adenocarcinoma cells. The aim of this study was to characterize RAS expression in human colon adenocarcinoma and to investigate whether Ang1-7 exerts an antiproliferative effect on human colon adenocarcinoma cells. Gene, protein expression and enzymatic activity of the main components of the RAS were determined on non-neoplastic colon mucosa as well as on the tumor mass and the mucosa taken 5 cm distant from it, both collected from patients with colon adenocarcinoma. Two different human colon cancer cell lines were treated with AngII and Ang1-7. The novel finding of this study was that MasR was significantly upregulated in colon adenocarcinoma compared with non-neoplastic colon mucosa, which showed little or no expression of it. ACE gene expression and enzymatic activity were also increased in the tumors. However, AngII and Ang1-7 did not have any pro-/antiproliferative effects in the cell lines studied. The data suggest that upregulation of the MasR could be used as a diagnostic marker of colon adenocarcinoma.

Gamma-radiation induced cross-links in ethylene-propylene rubber studied by CP-MAS NMR

International Nuclear Information System (INIS)

Sohma, J.; Shiotani, M.; Murakami, S.

1983-01-01

A new technique of 13 C-NMR, the CP-MAS method, was applied to study a chemistry of cross-links induced by #betta#-irradiation of ethylene-propylene rubber. The chemical species of cross-linking points were specified with their relative concentrations by the analysis of the CP-MAS spectra obtained before and after the irradiation. It was found that the short branches were also formed by the irradiation. A comparison was made between the cross-links detected by the CP-MAS method and those obtained by the Charlesby-Pinner analysis of the gelation caused by the #betta#-irradiation. The conventional 13 C-NMR of the cross-linked and swollen EPR provided us an information on the sol parts of the sample but little information on the cross-links in the gel parts. (author)

Angiotensin II Type 2 Receptor and Receptor Mas Are Colocalized and Functionally Interdependent in Obese Zucker Rat Kidney

DEFF Research Database (Denmark)

Patel, Sanket N; Ali, Quaisar; Samuel, Preethi

2017-01-01

The actions of angiotensin II type 2 receptor (AT2R) and the receptor Mas (MasR) are complex but show similar pronatriuretic function; particularly, AT2R expression and natriuretic function are enhanced in obese/diabetic rat kidney. In light of some reports suggesting a potential positive...... interaction between these receptors, we tested hypothesis that renal AT2R and MasR physically interact and are interdependent to stimulate cell signaling and promote natriuresis in obese rats. We found that infusion of AT2R agonist C21 in obese Zucker rats (OZR) increased urine flow and urinary Na excretion...... coimmunoprecipitated with MasR in cortical homogenate of OZR. Immunoblotting of cortical homogenate cross-linked with zero-length oxidative (sulfhydryl groups) cross-linker cupric-phenanthroline revealed a shift of AT2R and MasR bands upward with overlapping migration for their complexes which were sensitive...

ESTUDIO COMPARATIVO ENTRE DOS ESQUEMAS DE ACUPUNTURA ZUSANLI (E-36), SANYINJIAO (B-6), XUEHAI (B-10), TAICHONG (H-3) VS. MISMO ESQUEMA MAS QUANLIAO (ID-18) EN EL MANEJO DEL DOLOR Y LAS PARESTESIAS EN LA NEUROPATIA DIABETICA

OpenAIRE

VENEGAS CERVANTES, RAFAEL MELQUIADES

2010-01-01

LA NEUROPATIA DIABETICA (ND), COMPLICACION FRECUENTE DE LOS PACIENTES DIABETICOS, SE CARACTERIZA PORQUE EXISTEN ALTERACIONES EN LA PERCEPCION SOMATOSENSITIVA Y A NIVEL CIRCULATORIO (DOLOR, DISESTESIAS, PARESIAS Y PARESTESIAS). EN ESTA INVESTIGACION SE ESTUDIA EL EFECTO DE LA ACUPUNTURA, TANTO EN EL DOLOR, COMO EN LAS ALTERACIONES SENSITIVAS. PARA LO ANTERIOR SE UTILIZARON ACUPUNTOS DE EMPLEO ORDINARIO PARA LA ENFERMEDAD, HACIENDO UN COMPARATIVO CON EL MISMO ESQUEMA DE ACUPUNTOS, MAS LA ...

Exploring high-resolution magic angle spinning (HR-MAS) NMR spectroscopy for metabonomic analysis of apples.

Science.gov (United States)

Vermathen, Martina; Marzorati, Mattia; Vermathen, Peter

2012-01-01

Classical liquid-state high-resolution (HR) NMR spectroscopy has proved a powerful tool in the metabonomic analysis of liquid food samples like fruit juices. In this paper the application of (1)H high-resolution magic angle spinning (HR-MAS) NMR spectroscopy to apple tissue is presented probing its potential for metabonomic studies. The (1)H HR-MAS NMR spectra are discussed in terms of the chemical composition of apple tissue and compared to liquid-state NMR spectra of apple juice. Differences indicate that specific metabolic changes are induced by juice preparation. The feasibility of HR-MAS NMR-based multivariate analysis is demonstrated by a study distinguishing three different apple cultivars by principal component analysis (PCA). Preliminary results are shown from subsequent studies comparing three different cultivation methods by means of PCA and partial least squares discriminant analysis (PLS-DA) of the HR-MAS NMR data. The compounds responsible for discriminating organically grown apples are discussed. Finally, an outlook of our ongoing work is given including a longitudinal study on apples.

ESTUDIO COMPARATIVO DEL EFECTO DE ZHONGJI (RM3) MOXADO MAS PUNTOS REGULARES VS PUNTOS REGULARES EN PACIENTES CON NEUROPATIA DIABETICA -NO TIENE CARATULA-

OpenAIRE

LERMA GARCIA, HECTOR ALFONSO

2010-01-01

ANTECEDENTES: DESDE LA ANTIGUEDAD SE HA COMPROBADO LA EFECTIVIDAD DE LA ACUPUNTURA PARA EL TRATAMIENTO DEL DOLOR Y PARA LA DIABETES EN EL SER HUMANO. OBJETIVO: EL PRESENTE ESTUDIO TIENE COMO OBJETIVO ANALIZAR EL EFECTO DEL TRATAMIENTO DEL DOLOR Y ALTERACIONES SENSITIVAS EN PACIENTES CON NEUROPATIA DIABETICA. METODO: SE ESTUDIARON TREINTA PACIENTES CON UN DIAGNOSTICO DE NEUROPATIA DIABETICA LOS CUALES SE DIVIDIERON EN TRES GRUPOS A LOS CUALES SE LES APLICO EN EL GRUPO 1 ZHONG...

Effects of Continuous and Interval Training on Running Economy, Maximal Aerobic Speed and Gait Kinematics in Recreational Runners.

Science.gov (United States)

González-Mohíno, Fernando; González-Ravé, José M; Juárez, Daniel; Fernández, Francisco A; Barragán Castellanos, Rubén; Newton, Robert U

2016-04-01

The purpose of this study was to evaluate the effects on running economy (RE), V[Combining Dot Above]O2max, maximal aerobic speed (MAS), and gait kinematics (step length [SL] and frequency, flight and contact time [CT]) in recreational athletes, with 2 different training methods, Interval and Continuous (CON). Eleven participants were randomly distributed in an interval training group (INT; n = 6) or CON training group (CON; n = 5). Interval training and CON performed 2 different training programs (95-110% and 70-75% of MAS, respectively), which consisted of 3 sessions per week during 6 weeks with the same external workload (%MAS × duration). An incremental test to exhaustion was performed to obtain V[Combining Dot Above]O2max, MAS, RE, and gait variables (high speed camera) before and after the training intervention. There was a significant improvement (p ≤ 0.05) in RE at 60 and 90% of MAS by the CON group; without changes in gait. The INT group significantly increased MAS and higher stride length at 80, 90, and 100% of MAS and lower CT at 100% of MAS. As expected, training adaptations are highly specific to the overload applied with CON producing improvements in RE at lower percentage of MAS whereas INT produces improvements in MAS. The significantly increased stride length and decreased CT for the INT group are an important outcome of favorable changes in running gait.

Increasing brain angiotensin converting enzyme 2 activity decreases anxiety-like behavior in male mice by activating central Mas receptors.

Science.gov (United States)

Wang, Lei; de Kloet, Annette D; Pati, Dipanwita; Hiller, Helmut; Smith, Justin A; Pioquinto, David J; Ludin, Jacob A; Oh, S Paul; Katovich, Michael J; Frazier, Charles J; Raizada, Mohan K; Krause, Eric G

2016-06-01

Over-activation of the brain renin-angiotensin system (RAS) has been implicated in the etiology of anxiety disorders. Angiotensin converting enzyme 2 (ACE2) inhibits RAS activity by converting angiotensin-II, the effector peptide of RAS, to angiotensin-(1-7), which activates the Mas receptor (MasR). Whether increasing brain ACE2 activity reduces anxiety by stimulating central MasR is unknown. To test the hypothesis that increasing brain ACE2 activity reduces anxiety-like behavior via central MasR stimulation, we generated male mice overexpressing ACE2 (ACE2 KI mice) and wild type littermate controls (WT). ACE2 KI mice explored the open arms of the elevated plus maze (EPM) significantly more than WT, suggesting increasing ACE2 activity is anxiolytic. Central delivery of diminazene aceturate, an ACE2 activator, to C57BL/6 mice also reduced anxiety-like behavior in the EPM, but centrally administering ACE2 KI mice A-779, a MasR antagonist, abolished their anxiolytic phenotype, suggesting that ACE2 reduces anxiety-like behavior by activating central MasR. To identify the brain circuits mediating these effects, we measured Fos, a marker of neuronal activation, subsequent to EPM exposure and found that ACE2 KI mice had decreased Fos in the bed nucleus of stria terminalis but had increased Fos in the basolateral amygdala (BLA). Within the BLA, we determined that ∼62% of GABAergic neurons contained MasR mRNA and expression of MasR mRNA was upregulated by ACE2 overexpression, suggesting that ACE2 may influence GABA neurotransmission within the BLA via MasR activation. Indeed, ACE2 overexpression was associated with increased frequency of spontaneous inhibitory postsynaptic currents (indicative of presynaptic release of GABA) onto BLA pyramidal neurons and central infusion of A-779 eliminated this effect. Collectively, these results suggest that ACE2 may reduce anxiety-like behavior by activating central MasR that facilitate GABA release onto pyramidal neurons within the

A study on microwave oxidation of landfill leachate—Contributions of microwave-specific effects

International Nuclear Information System (INIS)

Chou, Yu-Chieh; Lo, Shang-Lien; Kuo, Jeff; Yeh, Chih-Jung

2013-01-01

Highlights: ► pH has an insignificant effect on TOC removals and 550 W has a well performance. ► MOP has well removals of color, UV 254 , and TOC at 550 W/85 °C. ► TOC removals were higher at higher microwave setting (550 W vs. 128 W). ► The microwave-specific effects on TOC removal were usually synergistic in MOP. ► COD analyses showed persulfate decayed rapidly in either MOP or CHO treatment. -- Abstract: Microwave oxidation process (MOP) was evaluated for treatment of landfill leachate. The experimental parameters include pH, temperature, oxidant doses, microwave power setting, and irradiation time. The study explored the microwave-specific effects of the MOP. The contributions of pure thermal, persulfate oxidation and microwave irradiation on TOC removal were quantified. It was then found the combinations of them were usually synergistic in MOP except two of them were antagonistic (128 W/85 °C/1 M Na 2 S 2 O 8 and 128 W/85 °C/2 M Na 2 S 2 O 8 ). At the highest temperature tested (85 °C) in this study, microwave irradiation may cause generation and termination of oxidizing radicals at adverse rates. The study also found that persulfate decayed rapidly in either MOP or conventional heating oxidation (CHO) treatment of landfill leachate

Evidence for Heterodimerization and Functional Interaction of the Angiotensin Type 2 Receptor and the Receptor MAS

DEFF Research Database (Denmark)

Leonhardt, Julia; Villela, Daniel C.; Teichmann, Anke

2017-01-01

The angiotensin type 2 receptor (AT2R) and the receptor MAS are receptors of the protective arm of the renin-angiotensin system. They mediate strikingly similar actions. Moreover, in various studies, AT2R antagonists blocked the effects of MAS agonists and vice versa. Such cross-inhibition may in...

Application of Model-Based Systems Engineering (MBSE) to Compare Legacy and Future Forces in Mine Warfare (MIW) Missions

Science.gov (United States)

2014-12-01

indicate that the satisfaction of these requirements had been addressed. 108 Table 8. MOP to Requirement Mapping Matrix MOP(s) REQUIREMENT 1.1...GUIs) to modify their behaviors. ExtendSim also has an equation editor for creating custom algorithms to add functionality not already present in the...Expeditionary Warfare Conference, Wyndham Bay Point Hotel , Panama City, FL, October 24. http://www.dtic.mil/ndia/2011expwar/MondayAmador.pdf. Bahr

X-ray fluorescent analysis on Indo-Pacific glass beads from Sungai Mas archaeological sites, Kedah, Malaysia

International Nuclear Information System (INIS)

Zuliskandar Ramli; Nik Hassan Shuhaimi; Nik Abdul Rahman; Abdul Latif Samian

2011-01-01

Sungai Mas was an ancient port-kingdom located on West Coast of Peninsula Malaysia in a district of Kota Kuala Muda, Kedah, Malaysia. The port-kingdom evolved as an entrepot since fifth century AD and continuously visited by international trader from India, China, Middle East and Europe until eighteenth century AD. Sungai Mas was also one of the Indo-Pacific beads making centers in Southeast Asia since sixth to thirteenth century AD and also produced pottery and brick. X-ray fluorescent analysis (XRF) on Sungai Mas Indo-Pacific beads is carried out to determine whether the glass beads originated from Arikamedu, India or locally made by community in Sungai Mas. Totally, twenty-two samples of beads and beads materials assayed by XRF were chosen. Contents of nine major elements and nine trace elements, which might be present of flux, stabilizer, colorants or opacifier were examined. The elements Si, Na, K, Ca, Fe, Al, Ti, Mn, Mg, Cu, Pb, Zr, Sr, Ba, La, U, Ni and Cr were detectable in all samples. The concentration of elements found are discussed in terms of flux, silica or lead base glass, color and/or opacity of the glass beads and glass samples. The result showed that Sungai Mas produced their own Indo-Pacific beads from sixth to thirteenth century AD. (author)

Stanowisko badawcze do oceny efektów utwardzania mas ze szkłem wodnym

Directory of Open Access Journals (Sweden)

M. Stachowicz

2012-12-01

Full Text Available W pracy przedstawiono wyniki badań nad możliwością zastosowania nowego stanowiska badawczego do oceny, na podstawie końcowejzawartości wody, finalnego efektu utwardzania wybranymi metodami mas ze szkłem wodnym. Badania wykonano na innowacyjnym,mobilnym stanowisku mikrofalowej linii szczelinowej wykorzystującej zjawisko występowania fali stojącej w falowodzie. Badaniompoddano pięć mas sporządzonych z dostępnymi w handlu gatunkami szkła wodnego, które utwardzano trzema, wybranymi metodami:mikrofalową, klasyczną oraz w procesie CO2. Wykazano, na przykładzie mas ze szkłem wodnym, że prezentowane, mobilne stanowiskopomiarowe może, na podstawie określenia końcowej zawartości wody, służyć z powodzeniem do oceny ostatecznego efektu utwardzaniamas formierskich i rdzeniowych.

ACE-2/Ang1-7/Mas cascade mediates ACE inhibitor, captopril, protective effects in estrogen-deficient osteoporotic rats.

Science.gov (United States)

Abuohashish, Hatem M; Ahmed, Mohammed M; Sabry, Dina; Khattab, Mahmoud M; Al-Rejaie, Salim S

2017-08-01

The local role of the renin angiotensin system (RAS) was documented recently beside its conventional systemic functions. Studies showed that the effector angiotensin II (AngII) alters bone health, while inhibition of the angiotensin converting enzyme (ACE-1) preserved these effects. The newly identified Ang1-7 exerts numerous beneficial effects opposing the AngII. Thus, the current study examines the role of Ang1-7 in mediating the osteo-preservative effects of ACEI (captopril) through the G-protein coupled Mas receptor using an ovariectomized (OVX) rat model of osteoporosis. 8 weeks after the surgical procedures, captopril was administered orally (40mgkg -1 d -1 ), while the specific Mas receptor blocker (A-779) was delivered at infusion rate of 400ngkg -1 min -1 for 6 weeks. Bone metabolic markers were measured in serum and urine. Minerals concentrations were quantified in serum, urine and femoral bones by inductive coupled plasma mass spectroscopy (ICP-MS). Trabecular and cortical morphometry was analyzed in the right distal femurs using micro-CT. Finally, the expressions of RAS peptides, enzymes and receptors along with the receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG) were determined femurs heads. OVX animals markedly showed altered bone metabolism and mineralization along with disturbed bone micro-structure. Captopril significantly restored the metabolic bone bio-markers and corrected Ca 2+ and P values in urine and bones of estrogen deficient rats. Moreover, the trabecular and cortical morphometric features were repaired by captopril in OVX groups. Captopril also improved the expressions of ACE-2, Ang1-7, Mas and OPG, while abolished OVX-induced up-regulation of ACE-1, AngII, Ang type 1 receptor (AT1R) and RANKL. Inhibition of Ang1-7 cascade by A-779 significantly eradicated captopril protective effects on bone metabolism, mineralization and micro-structure. A-779 also restored OVX effects on RANKL expression and ACE-1/AngII/AT1R

Marker-assisted-selection (MAS): A fast track to increase genetic ...

African Journals Online (AJOL)

Mapping and tagging of agriculturally important genes have been greatly facilitated by an array of molecular markers in crop plants. Marker-assisted selection (MAS) is gaining considerable importance as it would improve the efficiency of plant breeding through precise transfer of genomic regions of interest (foreground ...

ORGANIZACIÓN Y PLANIFICACIÓN EN NIÑOS CON TDAH: EVALUACIÓN Y PROPUESTA DE UN PROGRAMA DE ESTIMULACIÓN

Directory of Open Access Journals (Sweden)

Josefina Rubiales

2011-01-01

Full Text Available El Trastorno por Déficit de Atención e Hiperactividad (TDAH es un tra storno de origen neurobiológico complejo y heterogéneo que se caracteriza por un patrón persistente de desatención, hiperactividad y/o impulsividad. Es una de las alteraciones neuroconductuales mas frecuentes en la infancia y la adolescencia, y uno de los principales motivos de consulta debido a sus dificultades en el rendimiento e scolar, problemas de conducta, dificultades de convivencia en el hogar y con pares, afectación de la autoestima y agresividad . El déficit primario está asociado a una disfunción e jecutiva, entre las cuales se encuentra la organización y planificación. El objetivo del presente trabajo fue comparar el desempeño en organización y planificación de niños con y sin diagnóstico de TDAH y presentar una propuesta de estimulación acorde a su s necesidades . MATERIALES Y METODOS: L a muestra clínica conformada por 16 niños con diagnóstico de TDAH y la muestra control por 32 niños sin el diagnóstico, en ambos casos de 8 a 14 años de edad y de la ciudad de Mar del Plata (Argentina . Los instrumento s utilizados para evaluar la organización y planificación han sido el subtest Torres de México de la Batería Neuropsicológica Infantil (ENI, y las subp ruebas Construcción con cubos, Completamiento de Objetos y Ordenamiento de Historias del Test de Intelig encia de Weschler para niños y adolescentes. La propuesta de tratamiento incluye 8 sesiones de estimulación . RESULTADOS Y CONCLUSIONES: L os niños con diagnóstico de TDAH presentan mayor dificultad en la capacidad de organización y planificación que los niñ os de la muestra control; a partir de lo cual se establece una propuesta de estimulación, cuya ventaja y originalidad está acentuada en la validez ecológica del proce

Sex differences in the effects of adolescent social deprivation on alcohol consumption in μ-opioid receptor knockout mice.

Science.gov (United States)

Moriya, Yuki; Kasahara, Yoshiyuki; Hall, F Scott; Sakakibara, Yasufumi; Uhl, George R; Tomita, Hiroaki; Sora, Ichiro

2015-04-01

Evidence based on clinical and experimental animal studies indicates that adolescent social deprivation influences alcohol consumption in a sex-dependent manner, perhaps by influencing stress responses. However, the mechanisms underlying the interaction between these phenomena remain to be elucidated. Since the μ-opioid receptor (MOP) has been reported to have key roles in social stress responses as well as the reinforcing/addictive effects of ethanol, MOP is a candidate molecule that may link adolescent social deprivation and subsequent alterations in alcohol consumption. To evaluate the involvement of MOP and social isolation-induced changes in alcohol consumption, as well as the effect of sex differences on responses to social isolation, alcohol consumption was assessed using a two-bottle home-cage consumption procedure (8 % ethanol vs. water) in MOP knockout (MOP-KO) and wild type (WT) mice of both sexes exposed to adolescent social deprivation or reared socially. Isolation rearing had no effects upon alcohol consumption of WT mice, whereas it significantly altered alcohol consumption in both male and female MOP-KO mice. Interestingly, social isolation affected ethanol consumption differently in male and female mice. Ethanol consumption was increased in male MOP-KO mice, but decreased in female MOP-KO mice, by isolation rearing. These results indicate that disturbances of MOP function influence the effects of isolation rearing on ethanol consumption in a sex-dependent manner. Consequently, this suggests the possibility that genetic variation that influences MOP function may have differential roles in alcoholism in men and women, and alcoholism treatments that target MOP function may be differentially effective in males and females.

Angiotensin type 2 receptor (AT2R) and receptor Mas

DEFF Research Database (Denmark)

Villela, Daniel; Leonhardt, Julia; Patel, Neal

2015-01-01

The angiotensin type 2 receptor (AT2R) and the receptor Mas are components of the protective arms of the renin-angiotensin system (RAS), i.e. they both mediate tissue protective and regenerative actions. The spectrum of actions of these two receptors and their signalling mechanisms display striki...

REDUCCIÓN DE ÓXIDOSDE NITROGENO CON CATALIZADORES ZEOLÍTICOS INTERCAMBIADOS CON COBALTO

Directory of Open Access Journals (Sweden)

Enrique Alexis García Moya

2012-10-01

Full Text Available Se presenta un estudio sobre la reducción catalítica selectiva (RCS de NOx con metano en presencia de oxígeno en exceso con varios catalizadores a base de las zeolitas mordenita, ferrierita y ZSM-5 intercambiadas con diferentes cargas de cobalto y con las correspondientes zeolitas en forma acida. Cuando la mezcla reactiva contenía mayormente NO2 en lugar de NO, los catalizadores ácidos mostraron las más altas velocidades de formación de N2 en condiciones secas. Las mayores actividades se obtuvieron con los catalizadores Co-mordenita, siguiendo en orden de actividad los catalizadores Co-Ferrierita y Co-ZSM-5. El catalizador Co-Mordenita más activo se ensayó con una mezcla reactiva donde predominó el NO en lugar del NO2 bajo condiciones secas e hidrotérmicas y en presencia de SO2. Con la adición de 8% de agua a la mezcla de reacción se observó desactivación reversible, especialmente a bajas temperaturas. La adición de 60 ppm de SO2 disminuyó la velocidad de reacción aproximadamente a la mitad debido posiblemente al envenenamiento de algunos sitios activos.

48 CFR 538.270 - Evaluation of multiple award schedule (MAS) offers.

Science.gov (United States)

2010-10-01

... SERVICES ADMINISTRATION SPECIAL CATEGORIES OF CONTRACTING FEDERAL SUPPLY SCHEDULE CONTRACTING Establishing and Administering Federal Supply Schedules 538.270 Evaluation of multiple award schedule (MAS) offers... determining the Government's price negotiation objectives, consider the following factors: (1) Aggregate...

Phototherapy and photopharmacology

International Nuclear Information System (INIS)

Gasparro, F.P.; Chan, G.; Edelson, R.L.

1985-01-01

The activation of 8-methoxypsoralen (8-MOP) by long-wavelength ultraviolet A light (UVA, 320-400 nm) induces the formation of interstrand cross-links in DNA. Psoralen plus UVA (PUVA) is widely used in the treatment of psoriasis, a hyperproliferative disease of the skin. A new psoralen plus UVA therapy has been developed in which the 8-MOP-containing blood of cutaneous T cell lymphoma (CTCL) patients is irradiated with UVA light extracorporeally (i.e., extracorporeal photopheresis). The first group of patients had the leukemic variant of CTCL. A regimen of two treatments on successive days at monthly intervals produced a clinical response in eight of 11 patients. In this review the properties of several psoralens (both naturally occurring and synthetic derivatives) are compared, using several assays (DNA cross-linking, inhibition of lymphocyte response to mitogen stimulation, and cell viability). The development of a panel of monoclonal antibodies that recognize 8-MOP-modified DNA is also described. These antibodies have been used to quantitate 8-MOP photoadduct levels in human DNA samples. In addition to the psoralens, the light activation of two other compounds, gilvocarcin and an insulin-psoralen conjugate, is described

Stilistiskie izteiksmes līdzekļi Coca-Cola reklāmas plakātos

OpenAIRE

Gudre, Anete

2017-01-01

Šajā darbā tika pētīti mākslinieciskie un fonētiskie stila izteiksmes līdzekļi un to lietojums Coca-Cola reklāmas plakātos. Kā arī tika analizēti Coca-Cola reklāmas plakātu vizuālie elementi. Tēma tika izvēlēta, lai redzētu atšķirību starp mākslinieciskās izteiksmes līdzekļiem un, lai redzētu, cik bieži tie tiek izmantoti izvēlētajos reklāmas plakātos. Darbā tika aplūkoti vispopulārākie mākslinieciskās izteiksmes līdzekļi – metafora, epitets, personifikācija un hiperbola. Multimediju analīze ...

New marine commons along the Chilean coast – the management areas (MAs of Peñuelas and Chigualoco

Directory of Open Access Journals (Sweden)

Gloria L. Gallardo Fernández

2011-09-01

Full Text Available To halt degradation of benthic resources in Chile, management areas (MAs were set up under the Territorial Use Rights in Fisheries (TURFs framework in the late 1990s. Integrated into the global market, MAs have since expanded along the Chilean coast, involving thousands of small-scale artisanal fishers. This paper analyses how economic criteria relates to social and ecological performance of Chilean MAs, by applying TURFs, commons and co-management theory to two cases: MAs Peñuelas and Chigualoco. To collect and analyse data Participatory Rural Appraisal tools, interviews and official statistics and reports were used. Our results show that MAs’ economic benefits are connected to fluctuations on the global market. Adapting to changing world market prices then becomes paramount. TURFs’ main goal is ecological conservation, but achieving this seems to depend on meeting fishers’ livelihoods; failure to do so likely results in failure to meet conservation objectives. A serious weakness of the Chilean TURFs system is that it does not pay enough attention to fishers’ livelihoods or to the global market context. Furthermore, there is a strong relationship between good economic benefits and social sustainability. But irrespective of economic performance, fisher organizations have been empowered and gained increased resource control with the TURFs system. At policy level, a differentiated and more flexible system could be more suitable for existing heterogeneous MAs and their particular economic, social and ecological challenges. For improved economic sustainability and resource conservation, a system with multiple-species managing MAs could be promoted as well. Finally, to enhance theory of commons, co-management and TURFs, we argue for greater acknowledgement of TURFs’ social benefits in addition to economic assessments. More attention should also be paid to global market conditions of which MAs are dependent and in which they are embedded

Buffer standards for the physiological pH of the zwitterionic compound of 3-(N-morpholino)propanesulfonic acid (MOPS) from T = (278.15 to 328.15) K

International Nuclear Information System (INIS)

Roy, Lakshmi N.; Roy, Rabindra N.; Allen, Kathleen A.; Mehrhoff, Casey J.; Henson, Isaac B.; Stegner, Jessica M.

2012-01-01

Highlights: ► This work reports pH values of MOPS buffer. ► Liquid junction potential correction is applied. ► These values will be used by clinical and biomedical scientists. ► The pH values lie within 6.8 to 7.5. - Abstract: This paper reports the pH values of five NaCl-free buffer solutions and 11 buffer compositions containing NaCl at I = 0.16 mol · kg −1 . Conventional pa H values are reported for 16 buffer solutions with and without NaCl salt. The operational pH values have been calculated for five buffer solutions and are recommended as pH standards at T = (298.15 and 310.15) K after correcting the liquid junction potentials. For buffer solutions with the composition m 1 = 0.04 mol · kg −1 , m 2 = 0.08 mol · kg −1 , m 3 = 0.08 mol · kg −1 at I = 0.16 mol · kg −1 , the pH at 310.15 K is 7.269, which is close to 7.407, the pH of blood serum. It is recommended as a pH standard for biological specimens.

The effect of FF-MAS on porcine cumulus-oocyte complex maturation, fertilization and pronucleus formation in vitro

DEFF Research Database (Denmark)

Færge, Inger; Strejcek, Frantisek; Laurincik, Jozef

2006-01-01

mechanically using a fine glass pipette under constant pH and in vitro fertilized with fresh semen (5 x 105 spermatozoa/ml). The presumptive zygotes were evaluated 18 h after fertilization. The addition of pFF increased the monospermic as well as the polyspermic penetration of oocytes. In the absence of p......FF, the addition of FF-MAS decreased the polyspermic penetration rate, wehreas FF-MAS in combination with pFF decreased monospermic and increased polyspermic penetration. The degeneration rate of ova decreased in the presence of FF-MAS irrespective of the presence or absence of pFF. In the absence of pFF, FF...

Effects of Cornus mas L. and Morus rubra L. extracts on penicillin-induced epileptiform activity: an electrophysiological and biochemical study.

Science.gov (United States)

Tubaş, Filiz; Per, Sedat; Taşdemir, Abdulkadir; Bayram, Ayşe Kaçar; Yıldırım, Mehmet; Uzun, Aydın; Saraymen, Recep; Gümüş, Hakan; Elmalı, Ferhan; Per, Hüseyin

2017-01-01

Traditionally, Morus rubra L. (Moraceae) (red mulberry) and Cornus mas L. (Cornacea) (cornelian cherry) fruits are eaten fresh and are also used in marmalades, juices, jam, natural dyes in Turkey and are believed to have beneficial effects in case of multiple health issues such as antipyretic, diarrhea and intestinal parasites. However, the effects of M. rubra and C. mas on epilepsy has not been known. This study evaluates the effects of M. rubra and C. mas extracts on penicillin-induced epileptiform activity. Sixty Wistar rats randomly divided into ten groups (n=6): control, sham, penicillin, penicillin+M. rubra extract (2.5, 5, 10, 20 mg/kg) and penicillin+C. mas extract (2.5, 5, 10 mg/kg). Epileptiform activity was induced by using penicillin (500 IU, i.c.) and electrocorticogram records (150 min) were obtained. Also, biochemical analysis in blood samples were evaluated. According to the electrocorticogram analysis, the effective dose was detected as 10 mg/kg for both C. mas and M. rubra. This dose decreased the spike frequencies of convulsions while amplitude wasn't changed by both substances. In erythrocyte studies, there were significant differences regarding nitric oxide in the control, sham and penicillin groups. There were significant differences regarding malondialdehyde in all groups. In the plasma, there were significant differences among groups regarding xanthine oxidase in the penicillin‑C. mas and penicillin‑M. rubra groups. There were differences regarding malondialdehyde in the penicillin-C. mas and M. rubra-C. mas groups. Both extracts reduced the frequency of epileptiform activity. After administration of the extracts malondialdehyde levels decreased also in both erythrocytes and plasma.

Combined cycle simulator with gas turbine and steam turbine with one vaporization stage; Simulador de ciclo combinado con turbina de gas y de vapor con un nivel de vaporizacion

Energy Technology Data Exchange (ETDEWEB)

Del Valle Cardenas, B.; Lugo Leyte, R. [Universidad Autonoma Metropolitana, Depto de Ingenieria de Procesos e Hidraulica, Mexico, D. F. (Mexico); Toledo Velazquez, Miguel; Tolentino Eslava, G. [Seccion de Estudios de Posgrado e Investigacion, Laboratorio de Ingenieria Termica e Hidraulica Aplicada, ESIME-IPN-COFFA, Mexico, D. F. (Mexico)

1998-12-31

This paper shows the thermal analysis of a combined cycle with gas and steam turbines with one vaporization stage. The analysis is performed through a computer program, which allows the simulation of cycles with different operational conditions, obtaining this way a series of results that permits to know the way these cycles behave in effecting temperature and pressure changes; besides of being an excellent tool in thermodynamics for the user. The simulators were performed in Borland C++ and Builder C++ Versions 4.5 and 2.0 respectively, creating in this way a friendly ambient for the user. This tool offers the opportunity to all its users the ability to simulate combined cycles in a fast and easy way in order to obtain a wider understanding of its thermodynamic behavior. [Espanol] En el presente trabajo se muestra el analisis termico de un ciclo combinado con turbinas de gas y de vapor con un nivel de vaporizacion. El analisis se realiza a traves de un programa de computo, el cual permite simular los ciclos con diferentes condiciones de operacion, obteniendo con esto una serie de resultados que permiten conocer la forma en que trabajan estos ciclos al realizar cambios en temperaturas y presiones; ademas de que es una excelente herramienta para el usuario en termodinamica. Los simuladores fueron realizados en Borland C++ y Builder C++ Versiones 4.5 y 2.0 respectivamente, creandose asi un ambiente amigable para el usuario. Esta herramienta brinda la oportunidad a todos los usuarios de poder simular ciclos combinados de una manera rapida y sencilla con el fin de obtener una comprension mas amplia de su comportamiento termodinamico.

Combined cycle simulator with gas turbine and steam turbine with one vaporization stage; Simulador de ciclo combinado con turbina de gas y de vapor con un nivel de vaporizacion

Energy Technology Data Exchange (ETDEWEB)

Del Valle Cardenas, B; Lugo Leyte, R [Universidad Autonoma Metropolitana, Depto de Ingenieria de Procesos e Hidraulica, Mexico, D. F. (Mexico); Toledo Velazquez, Miguel; Tolentino Eslava, G [Seccion de Estudios de Posgrado e Investigacion, Laboratorio de Ingenieria Termica e Hidraulica Aplicada, ESIME-IPN-COFFA, Mexico, D. F. (Mexico)

1999-12-31

This paper shows the thermal analysis of a combined cycle with gas and steam turbines with one vaporization stage. The analysis is performed through a computer program, which allows the simulation of cycles with different operational conditions, obtaining this way a series of results that permits to know the way these cycles behave in effecting temperature and pressure changes; besides of being an excellent tool in thermodynamics for the user. The simulators were performed in Borland C++ and Builder C++ Versions 4.5 and 2.0 respectively, creating in this way a friendly ambient for the user. This tool offers the opportunity to all its users the ability to simulate combined cycles in a fast and easy way in order to obtain a wider understanding of its thermodynamic behavior. [Espanol] En el presente trabajo se muestra el analisis termico de un ciclo combinado con turbinas de gas y de vapor con un nivel de vaporizacion. El analisis se realiza a traves de un programa de computo, el cual permite simular los ciclos con diferentes condiciones de operacion, obteniendo con esto una serie de resultados que permiten conocer la forma en que trabajan estos ciclos al realizar cambios en temperaturas y presiones; ademas de que es una excelente herramienta para el usuario en termodinamica. Los simuladores fueron realizados en Borland C++ y Builder C++ Versiones 4.5 y 2.0 respectivamente, creandose asi un ambiente amigable para el usuario. Esta herramienta brinda la oportunidad a todos los usuarios de poder simular ciclos combinados de una manera rapida y sencilla con el fin de obtener una comprension mas amplia de su comportamiento termodinamico.

Reconfigurable digital receiver for 8PSK subcarrier multiplexed and 16QAM single carrier phase‐modulated radio over fiber links

DEFF Research Database (Denmark)

Guerrero Gonzalez, Neil; Zibar, Darko; Yu, Xianbin

2011-01-01

A reconfigurable digital receiver based on the k‐means algorithm is proposed for phase‐modulated subcarrier multiplexed (SCM) and quadrature amplitude‐modulated single carrier, phase‐modulated radio‐over‐fiber links. We report successful demodulation after 40 km single mode fiber transmission wit...... with three 50 Mbaud 8PSK SCM signals and a 312.5 Mbaud 16QAM single carrier. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:1015–1018, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25905...

Role of Mas receptor in renal blood flow response to angiotensin-(1-7) in ovariectomized estradiol treated rats.

Science.gov (United States)

Saberi, Shadan; Dehghani, Aghdas; Nematbakhsh, Mehdi

2016-01-01

The angiotensin 1-7 (Ang 1-7), is abundantly produced in kidneys and antagonizes the function of angiotensin II through Mas receptor (MasR) or other unknown mechanisms. In the current study, the role of MasR and steroid hormone estrogen on renal blood flow response to Ang 1-7 administration was investigated in ovariectomized (OV) female rats. OV female Wistar-rats received estradiol (500 μg/kg/week) or vehicle for two weeks. In the day of the experiment, the animals were anesthetized, cannulated, and the responses including mean arterial pressure, renal blood flow (RBF), and renal vascular resistance at the constant level of renal perfusion pressure to graded infusion of Ang 1-7 at 0, 100 and 300 ng/kg/min were determined in OV and OV estradiol-treated (OVE) rats, treated with vehicle or MasR antagonist; A779. RBF response to Ang 1-7 infusion increased dose-dependently in vehicle (Pdose <0.001) and A779-treated (Pdose <0.01) animals. However, when MasR was blocked, the RBF response to Ang 1-7 significantly increased in OV animals compared with OVE rats (P<0.05). When estradiol was limited by ovariectomy, A779 increased RBF response to Ang 1-7 administration, while this response was attenuated in OVE animals.

The demands and benefits of ergonomics in Sri Lankan apparel industry: A case study at MAS holdings.

Science.gov (United States)

Abeysekera, John; Illankoon, Prasanna

2016-10-17

Apparel exports bring in sizeable foreign income to Sri Lanka. To protect and promote this industry is a paramount need. This can be carried out by applying Human Factors/Ergonomics (HFE) which has proved to control negative effects at work places. This paper reports a case study which describes the demands and benefits of HFE in MAS Holdings which owns a large share of the apparel industry in Sri Lanka. The study consisted of walk through observation survey, a questionnaire survey and ergonomic work place analysis followed by a training programme to selected employees in three companies. Positive responses to questionnaires revealed good ergonomic practices in the work places surveyed. Ergonomically unfit chairs and potential hazards e.g. exposure to noise and hot environment were detected. It is seen that MAS have introduced strategies originated by Toyota Production System viz. 5S, Kaizen, six sigma etc., which are in fact ergonomic methods. A progressive project MAS boast of viz. 'MAS Operating System' (MOS) empowers training and development to employees. MAS Holdings has adequately realized the benefits of applying HFE as evident by the number of awards received. Relevant companies were advised to take appropriate corrective measures to control the potential hazards.

Hospitalidad, con y sin papeles

Directory of Open Access Journals (Sweden)

Ana Paula Penchaszadeh

Full Text Available Resumen El objetivo de este artículo es vincular el trabajo sobre el archivo de Jacques Derrida con la experiencia de la hospitalidad. Se intentará mostrar que, por un lado, se trata siempre de los papeles, de la legitimidad que éstos otorgan o no tanto a nivel filosófico (deseo de poseer los papeles que autoricen tal o cual decisión interpretativa, como a nivel político ("tener papeles" como el principio básico de todo derecho a tener derechos, de todo derecho a la comunidad. Mas también, por otro lado, se intentará pensar aquello que arruina la idea misma de tener o no tener (papeles, la idea de propiedad, aquello que hace imposible fundar una decisión o identidad en última instancia y, por ende, una soberanía, una frontera. La hospitalidad, la llegada inminente del otro, representa un desafío político y ético para la filosofía: pues no se trata de un saber, sino de una experiencia transformando el sustrato del nos-otros, del ser común.

29Si MAS NMR for the zeolite Y - gallium oxide system

International Nuclear Information System (INIS)

Sulikowski, B.; Derewinski, M.; Olejniczak, Z.; Segnowski, S.

1994-01-01

Wide-pore zeolites modified by gallium oxide has been prepared for catalytic use. Its physico-chemical and catalytic properties have been studied. The structure changes of the catalyst have been investigated by means of MAS NMR spectroscopy. Spectra of 29 Si has been described and discussed

Trabajando con tecnologías y afrontando el tecnoestrés: el rol de las creencias de eficacia

OpenAIRE

MARISA SALANOVA SORIA

2003-01-01

El objetivo del presente trabajo es describir qué es y cómo se produce el proceso de tecnoestrés en el marco mas global del 'Modelo Demandas-Recursos', con especial énfasis en describir los principales resultados de la investigación reciente sobre el rol amortiguador que tienen las creencias de eficacia en todo este proceso. Para ello se revisa en primer lugar el concepto de tecnoestrés ofreciendo una definición comprehensiva del constructo. En segundo lugar, se contextualiza el tecnoestrés e...

HR-MAS NMR allied to chemometric on Hancornia speciosa varieties differentiation

Energy Technology Data Exchange (ETDEWEB)

Flores, Igor S. [Instituto Federal de Goiás (IFG), Luziânia, GO (Brazil); Silva, Andressa K.; Chaves, Lazaro J.; Collevatti, Rosane G.; Lião, Luciano M., E-mail: lucianoliao@ufg.br [Universidade Federal de Goiás (UFG), Goiânia, GO (Brazil); Furquim, Leonnardo C. [Faculdade Objetivo, GO (Brazil); Castro, Carlos F.S. [Instituto Federal de Educação, Ciência e Tecnologia Goiano (IFGoiano), GO (Brazil)

2018-05-01

This work describes the potential of chemometric analyses applied to {sup 1}H high-resolution magic angle spinning nuclear magnetic resonance ({sup 1}H HR-MAS NMR) data for the chemotaxonomic investigation of Hancornia speciosa (Apocynaceae) varieties. This plant, popularly known as mangaba, has a complex morphological differentiation and thus chemical analyses can be used for their taxonomic classification. In comparison to traditional techniques, {sup 1}H HR-MAS NMR allied with chemometrics provided a simple and low cost method for chemotaxonomy. Leaves of four varieties of H. speciosa from a common garden experiment was studied and demonstrated that H. speciosa var. speciosa differs from others due to its specific metabolic profile, and var. pubescens was discriminated based on its high phenolic compound content. The distinction between the latter variety and gardineri is important once it allows for the selection of samples with greater commercial value, once they produce the largest and heaviest fruits. (author)

Asociación de linfomas malignos con herpes virus I y II

Directory of Open Access Journals (Sweden)

Ashley Efraín Alarcon-Rozas

2002-04-01

Full Text Available Objetivos: Conocer la prevalencia de la seropositividad para herpes virus I y II en pacientes con linfomas non Hodgkin y su asociación con el linaje celular (B ó T. Pacientes y métodos: Se tomó una muestra de 60 pacientes en el Hospital Almenara de agosto de 1999 a diciembre del 2000 todos ellos pacientes con diagnostico establecido de linfoma non Hodgkin nuevos o en primera recaída, el análisis se realizó mediante bioestadística descriptiva. Resultados: La mediana de la edad fue de 59 años, 2/3 fueron varones, 65% pacientes nuevos y el linfoma primario fue extraganglionar en un 58% de los casos. El 80% de los linfomas fueron a células B y mas del 90% en estadios avanzados (III y IV, ningún caso fue positivo para IgM herpes I o II y 25% tuvieron serología positiva IgG para herpes I o II (2/3 positivos para IgG I de los cuales el 93% fueron a células B. Conclusiones: La prevalencia de seropositividad para herpes virus I y II en pacientes con linfoma non Hodgkin es del 25%, mayormente asociado a células B, además de tener un porcentaje considerable de linfomas a células T (25% y linfomas extranodales (58%; para evaluar la posibilidad de asociación entre este virus y los linfomas requerimos de un estudio caso-control.

Measuring proton shift tensors with ultrafast MAS NMR.

Science.gov (United States)

Miah, Habeeba K; Bennett, David A; Iuga, Dinu; Titman, Jeremy J

2013-10-01

A new proton anisotropic-isotropic shift correlation experiment is described which operates with ultrafast MAS, resulting in good resolution of isotropic proton shifts in the detection dimension. The new experiment makes use of a recoupling sequence designed using symmetry principles which reintroduces the proton chemical shift anisotropy in the indirect dimension. The experiment has been used to measure the proton shift tensor parameters for the OH hydrogen-bonded protons in tyrosine·HCl and citric acid at Larmor frequencies of up to 850 MHz. Copyright © 2013 Elsevier Inc. All rights reserved.

NOMEX - a universal diagnostic dosemeter, mA.s, and kV meter for acceotance test measurements and quality assurance

International Nuclear Information System (INIS)

Hein, G.; Pychlau, P.; Schuele, E.

1992-01-01

A universal diagnostic dosemeter is introduced which was designed for acceptance test measurements and quality assurance. It can also be used for periodic constancy checks. To facilitate the comprehensive tests, the NOMEX can measure all important quantities, such as dose and dose rate, mean peak voltage, exposure time, mA.s product, dose per mA.s, dose per pulse, attenuation factor, relative standard deviation and length dose product in CT. All these quantities, except the mA.s product, are measured non-invasively. The instrument's concept, its applications and technical data are described. (author)

Lielveikalu RIMI reklāmas kampaņas ─ auditorijas uzmanības piesaistes analīze

OpenAIRE

Fjodorova, Margarita

2008-01-01

Mana darba tēma ir „Lielveikalu „RIMI” reklāmas kampaņas – auditorijas uzmanības piesaistes analīze.” Es apskatu 2003. – 2008.gada „RIMI” video reklāmas, lai pierādītu sava darba hipotēzi, ka „RIMI” lielveikalu video reklāmās laika posmā no 2003. līdz 2008. gadam nav bijis vienotu auditorijas uzmanības piesaistes elementu, bet tie tika ieturēti tikai kādas konkrētas reklāmas kampaņas robežās kā galvenie auditorijas uzmanības piesaistes elementi. Sava darba teorētiskajā daļā es pieturēšos pie ...

1H line width dependence on MAS speed in solid state NMR - Comparison of experiment and simulation

Science.gov (United States)

Sternberg, Ulrich; Witter, Raiker; Kuprov, Ilya; Lamley, Jonathan M.; Oss, Andres; Lewandowski, Józef R.; Samoson, Ago

2018-06-01

Recent developments in magic angle spinning (MAS) technology permit spinning frequencies of ≥100 kHz. We examine the effect of such fast MAS rates upon nuclear magnetic resonance proton line widths in the multi-spin system of β-Asp-Ala crystal. We perform powder pattern simulations employing Fokker-Plank approach with periodic boundary conditions and 1H-chemical shift tensors calculated using the bond polarization theory. The theoretical predictions mirror well the experimental results. Both approaches demonstrate that homogeneous broadening has a linear-quadratic dependency on the inverse of the MAS spinning frequency and that, at the faster end of the spinning frequencies, the residual spectral line broadening becomes dominated by chemical shift distributions and susceptibility effects even for crystalline systems.

Relación de cortisol sérico con los componentes del síndrome metabólico, ingesta alimentaria y trastorno de ansiedad en niños de 8 a 12 años con obesidad Relationship of serum cortisol and metabolic syndrome components, dietary intakes and anxiety disorder in children at 8 to 12 years of age with obesity

OpenAIRE

D.C. Treviño Villarreal; V. López Guevara; L.E. Ramírez López; A. Tijerina Sáenz

2012-01-01

Introducción: La obesidad es un trastorno que se asocia con ingesta alimentaria inadecuada y problemas psicológicos y predispone a complicaciones entre ellas el Síndrome Metabólico (SM), el cual ha sido relacionado con el estrés crónico debido a alteraciones en la actividad del eje Hipotálamo-Hipófisis-Adrenal (HHA) mediado por el hipercortisolismo. Objetivo: Determinar la relación del cortisol sérico con los componentes del SM, ingesta alimentaria y trastorno de ansiedad en niños de 8 a 12 a...

Participation and Performance Reporting for the Alternate Assessment Based on Modified Achievement Standards (AA-MAS). Technical Report 58

Science.gov (United States)

Albus, Deb; Thurlow, Martha L.; Lazarus, Sheryl S.

2011-01-01

This report examines publicly reported participation and performance data for the alternate assessment based on modified achievement standards (AA-MAS). The authors' analysis of these data included all states publicly reporting AA-MAS data, regardless of whether they had received approval to use the results for Title I accountability calculations.…

TÉCNICAS EVOLUTIVAS EN PROBLEMAS MULTI-OBJETIVOS EN EL PROCESO DE PLANIFICACIÓN DE LA PRODUCCIÓN / EVOLUTIONARY TECHNIQUES FOR MULTI-OBJECTIVE PROBLEMS IN PRODUCTION PLANNING

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Mariano Frutos-Alazard

2012-01-01

Full Text Available La planificación, en el ámbito productivo, se encarga de diseñar, coordinar, administrar y controlar todas las operaciones que se hallan presentes en la explotación de los sistemas productivos. En este marco de trabajo, aparecen numerosos Problemas de Optimización Multi-objetivo (MOPs. Éstos constan de varias funciones que suelen ser complejas y evaluarlas puede ser muy costoso. La optimización multi-objetivo es la disciplina que trata de encontrar las soluciones, denominadas Pareto óptimas, a este tipo de problemas. La compleja resolución de los MOPs es debida a las dimensiones propias del problema, al carácter combinatorio de los algoritmos y a la naturaleza de los objetivos, los cuales están vinculados a la eficiencia del sistema. En las últimas décadas muchos MOPs vinculados a la producción han sido tratados con éxito con técnicas de resolución basadas en Algoritmos Genéticos. En este trabajo se evalúa a NSGAII (Non-dominated Sorting Genetic Algorithm II, SPEAII (Strength Pareto Evolutionary Algorithm II y a sus antecesores, NSGA y SPEA, en el proceso de planificación de la producción no estandarizada. Luego de la experiencia realizada, el algoritmo NSGAII mostró mayor eficiencia.Planning in production environments takes care of designing, coordinating, managing and controlling all the operations existing in the use of productive systems. There are, in the framework analyzed within this work, several relevant Multi-Objective Optimization Problems (MOPs. They consist of several functions which tend to be complex and expensive to evaluate. Multi-objective optimization is the discipline developed to provide solutions, called Pareto optimal, for the simultaneous optimization of those functions. The costs of solving MOPs is due to the dimension of the problems, the combinatorial nature of the algorithms and the kind of objectives represented, linked to the efficiency of the system.. In the last decades several production

Estabilidad a la congelación descongelación de emulsiones o/w preparadas con aislados de soja nativos y desnaturalizados con diferente solubilidad

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Gonzalo Palazolo

2011-05-01

Full Text Available En este trabajo se evaluó la estabilidad a la congelación de emulsiones modelo aceite en agua (o/w preparadas con cuatro aislados de soja: dos nativos (ASN-1 y ASN-2, de similar composición pero diferente solubilidad, >90% y ~75%, respectivamente y dos desnaturalizados (ASD-1 y ASD-2, resultantes de calentar los respectivos aislados nativos (90 ‹C, 5 minutos. Las emulsiones preparadas con dispersiones acuosas al 2% p/v de ASN o ASD y aceite de girasol refinado (ƒ³ =0,25, se congelaron a -20 ‹C por 24 horas y luego se descongelaron a 20 ‹C. La estabilidad se evaluo a partir de medidas de distribución de tamano de partícula (difraccion laser y aceite liberado (AL, metodo de dilucion del colorante. Las emulsiones preparadas con ASN-2 y ASD-2 resultaron muy inestables despues de ser congeladas y descongeladas, resultadoque se evidenció por el aumento del tamano de partícula y un AL>25%. Al usar el aislado ASN-1 de mayor solubilidad, las emulsiones fueron mas estables y se observó un marcado incremento de la estabilidad cuando sus proteínas eran desnaturalizadas (ASD-1, no observándose prácticamente coalescencia ni aceite separado. En conclusión, la solubilidad y la desnaturalización proteíca de los aislados de soja son factores decisivos en la estabilidad de emulsiones frente a la congelación-descongelación.

Mas-allatotropin in the developing antennal lobe of the sphinx moth Manduca sexta: distribution, time course, developmental regulation, and colocalization with other neuropeptides.

Science.gov (United States)

Utz, Sandra; Huetteroth, Wolf; Vömel, Matthias; Schachtner, Joachim

2008-01-01

The paired antennal lobes (ALs) of the sphinx moth Manduca sexta serve as a well-established model for studying development of the primary integration centers for odor information in the brain. To further reveal the role of neuropeptides during AL development, we have analyzed cellular distribution, developmental time course, and regulation of the neuropeptide M. sexta allatotropin (Mas-AT). On the basis of morphology and appearance during AL formation, seven major types of Mas-AT-immunoreactive (ir) cells could be distinguished. Mas-AT-ir cells are identified as local, projection, and centrifugal neurons, which are either persisting larval or newly added adult-specific neurons. Complementary immunostaining with antisera against two other neuropeptide families (A-type allatostatins, RFamides) revealed colocalization within three of the Mas-AT-ir cell types. On the basis of this neurochemistry, the most prominent type of Mas-AT-ir neurons, the local AT neurons (LATn), could be divided in three subpopulations. The appearance of the Mas-AT-ir cell types occurring during metamorphosis parallels the rising titer of the developmental hormone 20-hydroxyecdysone (20E). Artificially shifting the 20E titer to an earlier developmental time point resulted in the precocious occurrence of Mas-AT immunostaining. This result supports the hypothesis that the pupal rise of 20E is causative for Mas-AT expression during AL development. Comparing localization and developmental time course of Mas-AT and other neuropeptides with the time course of AL formation suggests various functions for these neuropeptides during development, including an involvement in the formation of the olfactory glomeruli.

Gloriosos pois fingidos: o esvaimento dos deuses e o consílio marítimo D’os Lusíadas

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Luis Maffei

2015-01-01

Full Text Available Um dos aspectos mais importantes d’Os Lusíadas é a função desempenhada pelos deuses, especialmente Baco e Vênus, agentes centrais da ação em diversos momentos. Como o poema não é um épico clássico, insere-se num tempo histórico no qual, assim como nossa contemporaneidade, os deuses já não eram pertencentes ao sagrado, mas a um imaginário ficcional. Entender o poder dos deuses a partir de sua esvaziamento religioso é tarefa deste ensaio, que dialoga com dois textos recentes para afirmar não apenas a contemporaneidade de Camões, mas sua capacidade crítica: um verbete de Luís de Oliveira e Silva e um estudo de Luiza Nóbrega, ambos sobre o Consílio Marítimo do Canto VI, momento decisivo para as destinações de sentido de Baco e dos demais seres divinos de poema.

Modified Ashworth Scale (MAS) Model based on Clinical Data Measurement towards Quantitative Evaluation of Upper Limb Spasticity

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Puzi, A. Ahmad; Sidek, S. N.; Mat Rosly, H.; Daud, N.; Yusof, H. Md

2017-11-01

Spasticity is common symptom presented amongst people with sensorimotor disabilities. Imbalanced signals from the central nervous systems (CNS) which are composed of the brain and spinal cord to the muscles ultimately leading to the injury and death of motor neurons. In clinical practice, the therapist assesses muscle spasticity using a standard assessment tool like Modified Ashworth Scale (MAS), Modified Tardiue Scale (MTS) or Fugl-Meyer Assessment (FMA). This is done subjectively based on the experience and perception of the therapist subjected to the patient fatigue level and body posture. However, the inconsistency in the assessment is prevalent and could affect the efficacy of the rehabilitation process. Thus, the aim of this paper is to describe the methodology of data collection and the quantitative model of MAS developed to satisfy its description. Two subjects with MAS of 2 and 3 spasticity levels were involved in the clinical data measurement. Their level of spasticity was verified by expert therapist using current practice. Data collection was established using mechanical system equipped with data acquisition system and LABVIEW software. The procedure engaged repeated series of flexion of the affected arm that was moved against the platform using a lever mechanism and performed by the therapist. The data was then analyzed to investigate the characteristics of spasticity signal in correspondence to the MAS description. Experimental results revealed that the methodology used to quantify spasticity satisfied the MAS tool requirement according to the description. Therefore, the result is crucial and useful towards the development of formal spasticity quantification model.

1H HR-MAS NMR and S180 cells: metabolite assignment and evaluation of pulse sequence

International Nuclear Information System (INIS)

Oliveira, Aline L. de; Martinelli, Bruno César B.; Lião, Luciano M.; Pereira, Flávia C.; Silveira-Lacerda, Elisangela P.; Alcantara, Glaucia B.

2014-01-01

High resolution magic angle spinning 1 H nuclear magnetic resonance spectroscopy (HR-MAS NMR) is a useful technique for evaluation of intact cells and tissues. However, optimal NMR parameters are crucial in obtaining reliable results. To identify the key steps for the optimization of HR-MAS NMR parameters, we assessed different pulse sequences and NMR parameters using sarcoma 180 (S180) cells. A complete assignment of the metabolites of S180 is given to assist future studies. (author)

Reducción de color con cloruro de magnesio en soluciones con colorantes comerciales

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Mercedes Lucero Chávez

2017-01-01

Full Text Available Se experimentó con diferentes concentraciones de cloruro de magnesio (MgCl2 como coagulante para reducir el color en soluciones con colorantes comerciales: negro, azul y café. Los parámetros analizados fueron pH, color, demanda química de oxígeno ( dqo y sólidos suspendidos totales (sst de acuerdo con las Normas Mexicanas. Como prueba complementaria se agregó carbón activado a las muestras para reducir el color residual después de la coagulación-floculación. La reducción de los valores de color y dqo fue mayor cuando se adicionó más cantidad de MgCl2 (1.8 g/L. Los porcentajes de reducción fueron ≥90% para el color y >50% para la dqo. Los sst aumentaron con la adición de MgCl2. El carbón activado eliminó el color residual.

Radiofrequency fields in MAS solid state NMR probes

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Tošner, Zdeněk; Purea, Armin; Struppe, Jochem O.; Wegner, Sebastian; Engelke, Frank; Glaser, Steffen J.; Reif, Bernd

2017-11-01

We present a detailed analysis of the radiofrequency (RF) field over full volume of a rotor that is generated in a solenoid coil. On top of the usually considered static distribution of amplitudes along the coil axis we describe dynamic radial RF inhomogeneities induced by sample rotation. During magic angle spinning (MAS), the mechanical rotation of the sample about the magic angle, a spin packet travels through areas of different RF fields and experiences periodical modulations of both the RF amplitude and the phase. These modulations become particularly severe at the end regions of the coil where the relative RF amplitude varies up to ±25% and the RF phase changes within ±30°. Using extensive numerical simulations we demonstrate effects of RF inhomogeneity on pulse calibration and for the ramped CP experiment performed at a wide range of MAS rates. In addition, we review various methods to map RF fields using a B0 gradient along the sample (rotor axis) for imaging purposes. Under such a gradient, a nutation experiment provides directly the RF amplitude distribution, a cross polarization experiment images the correlation of the RF fields on the two channels according to the Hartmann-Hahn matching condition, while a spin-lock experiment allows to calibrate the RF amplitude employing the rotary resonance recoupling condition. Knowledge of the RF field distribution in a coil provides key to understand its effects on performance of a pulse sequence at the spectrometer and enables to set robustness requirements in the experimental design.

Banku reklāmas stratēģiju un valsts ekonomiskā stāvokļa mijiedarbība

OpenAIRE

Vernere, Elīna

2009-01-01

Darba tēma ir banku reklāmas stratēģiju un valsts ekonomiskā stāvokļa mijiedarbība. Galvenais pētījuma mērķis bija izprast, kā pašreizējā valsts ekonomiskā situācija izmainījusi sabiedrības vajadzības, pieprasījumu pēc banku pakalpojumiem un līdz ar to arī banku komunikāciju ar saviem klientiem ar vides reklāmas ziņojumu palīdzību. Galvenais pētījuma uzsvars tika likts uz reklāmas ziņojumu emocionālajiem un racionālajiem aspektiem. Papildus veiktajam pētījumam tika apskatīta arī reklāmas teor...

Pretreatment with UV light renders the chromatin in human fibroblasts more susceptible to the DNA-damaging agents bleomycin, gamma radiation and 8-methoxypsoralen

International Nuclear Information System (INIS)

Ljungman, Mats

1989-01-01

Confluent human fibroblast cultures were pretreated with either 254 nm UV light (UV) or methyl methanesulphonate (MMS), incubated at 37 0 C and subsequently challenged on ice with bleomycin (BLM), gamma-radiation or 8-methoxy-psoralen (MOP). The resulting number of challenge-induced DNA damages (measured as DNA strand breaks or cross-links) were compared with the numbers induced in similarly challenged but non-pretreated control cells. It was found that the timing of the subsequent challenge of cells pretreated with UV did significantly affect the amount of induced DNA damage. When the challenging agents were administered after a 10-20 min incubation period following UV pretreatment, the amount of induced DNA damage was increased 50% over control cells. In contrast, the timing of the subsequent challenge of cells pretreated with MMS has no influence on the level of challenge-induced damage. It is hypothesized that UV-irradiated chromatin undergoes a time-dependent decondensation that renders it more susceptible to the induction of strand breaks and cross-links by BLM, gamma-radiation and MOP. A possible role for chromatin decondensation in UV-induced excision repair is discussed. (author)

Ultrastructural modification of the plasma membrane in HUT 102 lymphoblasts by long-wave ultraviolet light, psoralen, and PUVA

International Nuclear Information System (INIS)

Malinin, G.I.; Lo, H.K.; Hornicek, F.J.; Malinin, T.I.

1990-01-01

Ultrastructural alterations of the plasma membrane in HUT 102 lymphoblasts were assessed after a 2-h interaction with a suprapharmacologic (15 micrograms/ml) concentration of 8-MOP, 2-h irradiation with UVA (2.1 mW/cm2), and the exposure of the HUT 102 cells to PUVA under the same conditions. The dark reaction of HUT cells with 8-MOP resulted in the disappearance of microvilli, the emergence of plasma-membrane-associated spherical bodies, formation of lamellar fungiform membrane evaginations, and, in approximately 1% of the cells, formation of uropods and cell capping. Except for uropod formation and cell capping, UVA has induced the same plasma-membrane alterations, and was more deleterious to structural cytoplasmic integrity than 8-MOP. Morphologic changes of the plasma membrane in PUVA-exposed cells tended to replicate structural alterations elicited independently during the dark reaction by suprapharmacologic 8-MOP concentrations. Partial retention of microvilli by cells after PUVA was the sole exception. In light of all available evidence we conclude that psoralen during the dark reactions interacts with plasma membrane lipids by as yet undisclosed mechanisms and that in addition to lipids, membrane proteins are also the primary target of the initial interaction of HUT 102 cells with psoralen during PUVA treatment

Brain structural properties predict psychologically mediated hypoalgesia in an 8-week sham acupuncture treatment for migraine.

Science.gov (United States)

Liu, Jixin; Mu, Junya; Liu, Qianqian; Dun, Wanghuan; Zhang, Ming; Tian, Jie

2017-09-01

Neuroimaging studies described brain structural changes that comprise the mechanisms underlying individual differences in migraine development and maintenance. However, whether such interindividual variability in migraine was observed in a pretreatment scan is a predisposition for subsequent hypoalgesia to placebo treatment that remains largely unclear. Using T1-weighted imaging, we investigated this issue in 50 healthy controls (HC) and 196 patients with migraine without aura (MO). An 8-week double-blinded, randomized, placebo-controlled acupuncture was used, and we only focused on the data from the sham acupuncture group. Eighty patients participated in an 8-weeks sham acupuncture treatment, and were subdivided (50% change in migraine days from baseline) into recovering (MOr) and persisting (MOp) patients. Optimized voxel-based morphometry (VBM) and functional connectivity analysis were performed to evaluate brain structural and functional changes. At baseline, MOp and MOr had similar migraine activity, anxiety and depression; reduced migraine days were accompanied by decreased anxiety in MOr. In our findings, the MOr group showed a smaller volume in the left medial prefrontal cortex (mPFC), and decreased mPFC-related functional connectivity was found in the default mode network. Additionally, the reduction in migraine days after placebo treatment was significantly associated with the baseline gray matter volume of the mPFC which could also predict post-treatment groups with high accuracy. It indicated that individual differences for the brain structure in the pain modulatory system at baseline served as a substrate on how an individual facilitated or diminished hypoalgesia responses to placebo treatment in migraineurs. Hum Brain Mapp 38:4386-4397, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

Le Kāmasūtra et la « pulsion shastrique » en Inde

OpenAIRE

Naudou, Elizabeth

2013-01-01

Le mot « shastrique » fait référence au traité (śāstra) d’où sont issus les Kāmasūtra, (plus généralement appelé le Kāmasūtra), « aphorismes sur l’amour » : le Kāmaśāstra, « traité sur l’amour ». Qui dit śāstra, dit, en Inde, exposé religieux ou scientifique, d’où l’expression « pulsion shastrique » que l’on pourrait rendre par « pulsion encyclopédique énumérative et classificatoire ». Le but de cet exposé est de replacer le texte dans cette structure mentale typiquement indienne, qui reflète...

EVALUASI DAYA TAHAN IKAN MAS HASIL SELEKSI BERDASARKAN MARKA MOLEKULER MHC-II TERHADAP INFEKSI KOI HERPES VIRUS

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Erma Primanita Hayuningtyas

2015-03-01

mengevaluasi daya tahan benih ikan mas F-1 terseleksi terhadap infeksi KHV melalui uji tantang. Sebagai pembanding, digunakan ikan mas populasi benih F-1 non-seleksi dan populasi benih ikan mas dari unit pembenihan rakyat (UPR. Ikan uji berupa benih ikan mas Rajadanu berumur dua bulan dengan bobot ratarata 5,5±0,5 g. Jumlah benih pada masing-masing wadah perlakuan sebanyak 30 ekor dengan tiga kali pengulangan. Wadah pengujian berupa akuarium berukuran 40 cm x 60 cm x 40 cm dengan kepadatan 1 ekor/L. Parameter yang diamati adalah sintasan, deteksi KHV, analisis ekspresi gen MHC-II, dan gambaran darah ikan. Hasil penelitian menunjukkan bahwa populasi benih F-1 terseleksi memiliki daya tahan lebih baik dengan sintasan 93,33% dibandingkan populasi benih F-1 non-seleksi sebesar 85,55% dan populasi benih dari UPR sebesar 81,11%. Daya tahan yang tinggi pada populasi benih F-1 terseleksi didukung oleh hasil deteksi KHV yang negatif dan ersentase jumlah limfosit yang lebih tinggi sebesar 91,67%; serta rendahnya persentase monosit dan heterofil, selain itu, tidak adanya eosinofil dan basofil. Ekspresi gen MHC-II terdeteksi pada berbagai organ, ekspresi tertinggi ditemukan pada organ limpa.

In situ high temperature MAS NMR study of the mechanisms of catalysis. Ethane aromatization on Zn-modified zeolite BEA.

Science.gov (United States)

Arzumanov, Sergei S; Gabrienko, Anton A; Freude, Dieter; Stepanov, Alexander G

2009-04-01

Ethane conversion into aromatic hydrocarbons over Zn-modified zeolite BEA has been analyzed by high-temperature MAS NMR spectroscopy. Information about intermediates (Zn-ethyl species) and reaction products (mainly toluene and methane), which were formed under the conditions of a batch reactor, was obtained by (13)C MAS NMR. Kinetics of the reaction, which was monitored by (1)H MAS NMR in situ at the temperature of 573K, provided information about the reaction mechanism. Simulation of the experimental kinetics within the frames of the possible kinetic schemes of the reaction demonstrates that a large amount of methane evolved under ethane aromatization arises from the stage of direct ethane hydrogenolysis.

Chemical profile of beans cultivars (Phaseolus vulgaris) by 1H NMR - high resolution magic angle spinning (HR-MAS);Perfil quimico de cultivares de feijao (Phaseolus vulgaris) pela tecnica de high resolution magic angle spinning (HR-MAS)

Energy Technology Data Exchange (ETDEWEB)

Liao, Luciano Morais; Choze, Rafael; Cavalcante, Pedro Paulo Araujo; Santos, Suzana da Costa; Ferri, Pedro Henrique, E-mail: luciano@quimica.ufg.b [Universidade Federal de Goias (UFG), Goiania, GO (Brazil). Inst. de Quimica; Ferreira, Antonio Gilberto [Universidade Federal de Sao Carlos (UFScar), SP (Brazil). Dept. de Quimica

2010-07-01

The application of one-dimensional proton high-resolution magic angle spinning ({sup 1}H HR-MAS) NMR combined with a typical advantages of solid and liquid-state NMR techniques was used as input variables for the multivariate statistical analysis. In this paper, different cultivars of beans (Phaseolus vulgaris) developed and in development by EMBRAPA - Arroz e Feijao were analyzed by {sup 1}H HR-MAS, which have been demonstrated to be a valuable tool in its differentiation according chemical composition and avoid the manipulation of the samples as used in other techniques. (author)

El medievalismo fértil de Paloma Díaz-Mas

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Rafael M. Mérida Jiménez

2001-01-01

Full Text Available The author of this article is concerned with trying to understand why Paloma Díaz-Mas, the writer of such an excellent novel as La tierra fértil (1999, has not received much critical attention. He underlines three main reasons. First, she does not live in Madrid or Barcelona and so she is far away from the main centres of cultural power. Second, she teaches Spanish literature in the Basque Country, a political and linguistic community which significantly differs from that of many other writers. Third, she writes historical novels, which does not appear to be very fashionable in Spain these days. Moreover, Díaz-Mas is a woman writer who does not make use of the most commonly available feminine patterns, and she does not seem to offer a model easy to include in a given feminist methodology either. However, Mérida-Jiménez argues that Paloma provides an intelligent deconstruction of “male authority” through subtle rhetorical means, as well as a representation of the weakness of his “domination” in very innovative ways, such as those derived from the dialectics between history and fiction, centrality and marginality, heterosexuality and homosexuality, individual and society, dream and reason or tradition and modernity.

The cave paintings of the Covatina del Tossalet del Mas de la Rambla», Vilafranca, Castellón | Las pinturas rupestres de la "Covatina del Tossalet del Mas de la Rambla", Villafranca, Castellón | Las pinturas rupestres de la "Covatina del Tossalet del Mas de la Rambla", Villafranca, Castellón

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Norberto Mesado Olivier

1989-12-01

Full Text Available Vilafranca, en el linde N del País, conserva en «La Covatina del Tossalet del Mas de la Rambla», un grupo de unas 24 figuras pertenecientes al tradicionalmennte denominado «Arte Levantino», y que recientemente hemos convenido en llamar «Arte Rupestre del Neolítico Inciso». Destaca por novedosa la caza de una gran ave rapaz (posiblemente un córvido, herida por un proyectil procedente de una honda, arma que lleva un bello cazador en «vuelo», el cual viste sofisticadamente. Otro grupo de figuras humanas singulares aparecen capturando víboras, práctica que llegó tanto en Vilafranca como en el vecino pueblo de Castellfort, a los inicios del siglo XX. Tan singular depredación habrá de relacionarse con la extracción del mortífero veneno de la «vípera Latasti». Su empleo tanto pudo servir para empozoñar las puntas de las saetas de los cazadores prehistóricos de este importantísimo foco del Maestrazgo, o como «fármacos» al estilo de la «Triaca Magna». | Vilafranca, dans la limite Nord du Pays, a dans «La Covatina del Tossalet del Mas de la Rambla», un groupe d'unes 24 figures appartenant au traditionnelment dénomme «Arte Levantino» et que récemment on a accordé dénomé «Art Rupestre du Néolithique Haché». Détache, par nouvelle, la chasse d'un gran oiseau de proie (possiblement un Corvidé, bléssé par un projectile originaire d'une fronde d'un chasseur, lequel est habillé sophistiquément. Un autre groupe de figures humaines se trouve chassant des vipéres, usage qui est arrivé á Vilafranca jusqu'au XXéme siécle. Cette singuliére chasse doit étre lié a l'extraction du poison meutrier de la «Vipera Latasti». Sa finalité aurait bien pu étre empoisonner les pointes dis fleches utilisées par les chasseurs préhistoriques de cette tres importante aire du «Maestrazgo»; ou bien comme «medicament» du méme type que la »Triarca Magna».

{sup 1}H HR-MAS NMR and S180 cells: metabolite assignment and evaluation of pulse sequence

Energy Technology Data Exchange (ETDEWEB)

Oliveira, Aline L. de; Martinelli, Bruno César B.; Lião, Luciano M. [Universidade Federal de Goiás (UFG), Goiânia, GO (Brazil). Instituto de Química. Lab. de RMN; Pereira, Flávia C.; Silveira-Lacerda, Elisangela P. [Universidade Federal de Goiás (UFG), Goiânia, GO (Brazil). Instituto de Ciências Biológicas. Laboratório Genética Molecular e Citogenética; Alcantara, Glaucia B., E-mail: glaucia.alcantara@ufms.br [Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, MS (Brazil). Inst. de Química

2014-07-01

High resolution magic angle spinning {sup 1}H nuclear magnetic resonance spectroscopy (HR-MAS NMR) is a useful technique for evaluation of intact cells and tissues. However, optimal NMR parameters are crucial in obtaining reliable results. To identify the key steps for the optimization of HR-MAS NMR parameters, we assessed different pulse sequences and NMR parameters using sarcoma 180 (S180) cells. A complete assignment of the metabolites of S180 is given to assist future studies. (author)

CONCEPTUALIZACIÓN Y ANÁLISIS DE UN SISTEMA MULTI-AGENTE PEDAGÓGICO UTILIZANDO LA METODOLOGÍA MAS-COMMONKADS

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JOVANI ALBERTO JIMÉNEZ BUILES

2009-01-01

Full Text Available En este artículo se presentan la conceptualización y el análisis de un sistema multi-agente (MAS pedagógico utilizando la metodología MAS-CommonKADS; la cual es una de las más reconocidaspara el modelado de MAS. El propósito de la fase de conceptualización es comprender el problema, identificar los actores activos y pasivo, además de elaborar los requisitos que permitan formular unos objetivos para generar la solución. En la fase de análisis se definen los modelos de agente, tareas, coordinación, comunicación, organizacióny experiencia (conocimientos. Ambas fases fueron validadas mediante la construcción del ambiente multi agente pedagógico ALLEGRO.

Deuterium and lithium-6 MAS NMR studies of manganese oxide electrode materials

Science.gov (United States)

Paik, Younkee

Electrolytic manganese dioxide (EMD) is used world wide as the cathode materials in both lithium and alkaline primary (non-rechargeable) batteries. We have developed deuterium and lithium MAS NMR techniques to study EMD and related manganese oxides and hydroxides, where diffraction techniques are of limited value due to a highly defective nature of the structures. Deuterons in EMD, manganite, groutite, and deuterium-intercalated pyrolusite and ramsdellite were detected by NMR, for the first time, and their locations and motions in the structures were analyzed by applying variable temperature NMR techniques. Discharge mechanisms of EMD in alkaline (aqueous) electrolytes were studied, in conjunction with step potential electrochemical spectroscopic (SPECS) method, and five distinctive discharge processes were proposed. EMD is usually heat-treated at about 300--400°C to remove water to be used in lithium batteries. Details of the effects of heat-treatment, such as structural and compositional changes as a function of heat-treatment temperature, were studied by a combination of MAS NMR, XRD, and thermogravimetric analysis. Lithium local environments in heat-treated EMD (HEMD) that were discharged in lithium cells, were described in terms of related environments found in model compounds pyrolusite and ramsdellite where specific Li + sites were detected by MAS NMR and the hyperfine shift scale method of Grey et al. Acid-leaching of Li2MnO3 represents an approach for synthesizing new or modified manganese oxide electrode materials for lithium rechargeable batteries. Progressive removal of lithium from specific crystallographic sites, followed by a gradual change of the crystal structure, was monitored by a combination of NMR and XRD techniques.

Diseño y desarrollo de una barra vibratoria: actividad neuromuscular durante el ejercicio con vibración de las extremidades superiores

OpenAIRE

Rodríguez Jiménez, Sergio

2015-01-01

[spa] El ejercicio con vibración (EJV) se ha convertido en la última década en una modalidad de ejercicio complementaria al entrenamiento. Las plataformas vibratorias son los dispositivos mas populares y practicos para transmitir la vibración por los pies a las extremidades inferiores mientras se realizan ejercicios estéticos y dinámicos. Otros tipos de dispositivos, tomo las mancuernas vibratorias y diversos sistemas de transmisión de la vibración por cable, se utilizan exclusivamente para t...

Abordaje transumbilical en pacientes pediátricos con sospecha de apendicitis aguda. Un serie de 424 pacientes

Directory of Open Access Journals (Sweden)

Luis Augusto Zárate Suárez

2013-05-01

Full Text Available Antecedentes: El tratamiento de la apendicitis aguda implica su extirpación; es frecuente la solicitud de cicatrices postquirúrgicas del mejor tamaño posible. Una de las estrategias disponibles es el abordaje transumbilical. Objetivos: Descubrir las características clínicas y los desenlaces operatorios de los pacientes pediátricos en quienes se realiza apendicectomía vía transumbilical. Metodología: Estudio prospectivo de 424 pacientes sucesivos en cuanto a los desenlaces operatorios a corto plazo. Resultados: El tiempo promedio de intervención quirúrgica fue de 22 minutos; 95,8% de los pacientes presentó evolución satisfactoria del postquirúrgico; 1,4% de los pacientes se reintervino para drenar un absceso intracavitario residual y 0,2% presentó infencción de sitio operatorio sin mas complicaciones. Conclusión: El abordaje transumbilical de la apendicitis es una alternativa minimamente invasiva para todos los estados de apendicitis aguda e implica disminución del tiempo de realización, menor estancia del postquirúrgico, menor incidencia de complicaciones y mayor conformidad con los resultados estéticos.

Inversor Resonante de Tres Elementos L-LC con Caracteristica Cortocircuitable para Aplicaciones de Calentamiento por Induccion

Science.gov (United States)

Espi Huerta, Jose Miguel

seccion de entrada mediante un mayor o menor aporte de corriente al puente. Como consecuencia, la seccion de entrada del paralelo, ya de por si mas voluminosa que lao del serie por el uso de grandes componentes magneticos (bobinas de filtro o de "alisamiento"), result a tambien mas complicada y costosa debido a la necesidad de ser implementada mediante rectificador controlado. Ademas, la regulacion que ofrece el rectificador es pobre, dada su baja frecuencia de conmutacion. En cambio, el circuito serie puede funcionar por encima de la resonancia manteniendo una secuencia de conmutacion sin riesgos de recuperacion inversa y con una corriente de salida practicamente sinusoidal, lo que permite un control de la potencia por variacion de frecuencia. Puesto que la tarea de regulacion se realiza desde el puente inversor, la regulacion resulta mucho mas eficaz y la seccion de entrada se puede implementar mediante un simple rectificador no controlado y un condensador de filtro. (Abstract shortened by UMI.).

Synthesis and structure of dihydridodichloro-tetrakis-(dimethylphenylphosphine)molybdenum

International Nuclear Information System (INIS)

Lenenko, V.S.; Yanovskij, A.I.; Struchkov, Yu.T.; Shur, V.B.; Vol'pin, M.E.

1986-01-01

The molybdenum hydride complex (Me 2 PhP) 4 MoH 2 Cl 2 (1) characterized by infrared and nmr spectra and studied using x-ray diffraction method is produced in the course of (THF) 3 MoCl 3 reduction in the Me 2 PhP presence. Crystals 1 are triclinic, at -120 deg a=8.092, b=9.820, c=22.73 A, α=86.13, β=89.28, γ=67.52 deg, Z=2, sp.gr. Panti1. Mo atom coordination polyhedron can be described as distorted triagular dodecahedron Mo-P bond lengths differ considerably: longer bonds such as Mo-P 2.544 and 2.531 A form an angle of 157.8 deg, an angle between shorter bonds such as Mo-P 2.459 and 2.445 A is 119.6 deg; other PMoP angles fall into the interval of 90.6-100.0 deg Mo-P and Mo-Cl (2.542 and 2.532 A) bonds in complex 1 are close to the corresponding distances in its tungsten analogue investigated before

An Analysis of the Rise and Fall of the AA-MAS Policy

Science.gov (United States)

Lazarus, Sheryl S.; Thurlow, Martha L.; Ysseldyke, James E.; Edwards, Lynn M.

2015-01-01

In 2005, to address concerns about students who might fall in the "gap" between the regular assessment and the alternate assessment based on alternate achievement standards (AA-AAS), the U.S. Department of Education announced that states could develop alternate assessments based on modified achievement standards (AA-MAS). This article…

Microscopic structural analysis of fractured silk fibers from Bombyx mori and Samia cynthia ricini using 13C CP/MAS NMR with a 1 mm microcoil MAS NMR probehead

KAUST Repository

Yamauchi, Kazuo

2010-07-01

Conformational changes have been studied in silk fibers from the domestic silkworm Bombyx mori and a wild silkworm Samia cynthia ricini as a result of fractured by stretching. About 300 samples consisting of only the fractured regions of [1-13C]Ala or [1-13C]Gly labeled silk fibers were collected and observed by 13C CP/MAS NMR spectra. The total amount of these fractured fibers is only about 1 mg and therefore we used a home-built 1 mm microcoil MAS NMR probehead. A very small increase in the fraction of random coil was noted for the alanine regions of both silk fibroins and for the glycine region of B. mori silk fibroin. However, there is no difference in the spectra before and after fractured for the glycine region of S. c. ricini silk fibroin. Thus, the influence of fracture occurs exclusively at the Ala region for S. c. ricini. The relationship between sequence, fracture and structure is discussed. © 2010 Elsevier Inc. All rights reserved.

Presa con revestimiento asfáltico

Directory of Open Access Journals (Sweden)

Proudfit, D. P.

1960-07-01

Full Text Available La presa denominada Montgomery se halla situada sobre el río South Platte River, a unos 8 km aguas arriba de la ciudad de Alma, del Estado de Colorado (EE. UU., y en la ladera oriental de la cordillera Continental Divide. El cuerpo o dique de esta presa está constituido por piedra, revestida con una capa de hormigón asfáltico en el paramento de contacto con el agua.

Trabajando con tecnologías y afrontando el tecnoestrés: el rol de las creencias de eficacia

Directory of Open Access Journals (Sweden)

MARISA SALANOVA SORIA

2003-01-01

Full Text Available El objetivo del presente trabajo es describir qué es y cómo se produce el proceso de tecnoestrés en el marco mas global del 'Modelo Demandas-Recursos', con especial énfasis en describir los principales resultados de la investigación reciente sobre el rol amortiguador que tienen las creencias de eficacia en todo este proceso. Para ello se revisa en primer lugar el concepto de tecnoestrés ofreciendo una definición comprehensiva del constructo. En segundo lugar, se contextualiza el tecnoestrés en el marco más global de los Modelos Demandas- Recursos, apuntando los principales hallazgos en la investigación sobre las características del trabajo con Tecnologías de la Información y Comunicación (TIC. El artículo finaliza revisando la investigación reciente sobre la autoeficacia como un recurso 'amortiguador' del proceso de tecnoestrés.

77 FR 43084 - Multiple Award Schedule (MAS) Program Continuous Open Season-Operational Change

Science.gov (United States)

2012-07-23

... (GSA), Federal Acquisition Service (FAS) intends to institute a Demand Based Model (DBM) designed to... will restore and maintain the MAS program's value to Federal agencies as a streamlined acquisition... adding innovative solutions, improving pricing and simplifying the buying experience. DATES: This change...

Immunity to potato mop-top virus in Nicotiana benthamiana plants expressing the coat protein gene is effective against fungal inoculation of the virus.

Science.gov (United States)

Reavy, B; Arif, M; Kashiwazaki, S; Webster, K D; Barker, H

1995-01-01

Nicotiana benthamiana stem tissue was transformed with Agrobacterium tumefaciens harboring a binary vector containing the potato mop-top virus (PMTV) coat protein (CP) gene. PMTV CP was expressed in large amounts in some of the primary transformants. The five transgenic lines which produced the most CP were selected for resistance testing. Flowers on transformed plants were allowed to self-fertilize. Transgenic seedlings selected from the T1 seed were mechanically inoculated with two strains of PMTV. Virus multiplication, assayed by infectivity, was detected in only one transgenic plant of 98 inoculated. T1 plants were also highly resistant to graft inoculation; PMTV multiplied in only one plant of 45 inoculated. Transgenic T1 seedlings were challenged in a bait test in which they were grown in soil containing viruliferous spores of the vector fungus Spongospora subterranea. In these tests only two plants out of 99 became infected. Of the five transgenic lines tested, plants of three lines were immune to infection following manual, graft, or fungal inoculation.

Personālā datora sistēmas bloka vides snieguma novērtējums un ekodizaina analīze

OpenAIRE

Šteina, Māra

2009-01-01

Maģistra darba „Personālā datora sistēmas bloka vides snieguma novērtējums un ekodizaina analīze” pamatā ir biroja datora sistēmas bloka ietekmes uz vidi novērtējums visā tā dzīves cikla laikā, izvērtējot arī lietotāju un iesaistīto pušu nozīmi. Darbs sastāv no divām daļām – teorētiskās un praktiskās. Pirmā daļa ir teorētiskajā daļa, kurā autore apskatīja pieejamos literatūras avotus un citu autoru darbus, izvērtējot tēmas aktualitāti, galvenās problēmas un to risinājumus. Otrā daļa ...

Porcentaje de grasa corporal en escolares y su asociación con el estilo de vida y macronutrientes

Directory of Open Access Journals (Sweden)

Eloína Ruiz Sánchez

2015-07-01

Full Text Available Introducción: Identificar la asociación entre los estilos de vida, el consumo de macronutrientes  y el porcentaje de grasa corporal en escolares, y comparar por estado de peso. Materiales y Métodos: Corte transversal analítico en escolares de la ciudad de Durango a quienes se les midió antropometría, presión arterial, antecedentes familiares, estilos de vida y consumo de macronutrientes. El análisis de datos  fue descriptivo, se obtuvieron medidas de tendencia central de las variables cuantitativas que mostraron una distribución normal. Las variables cualitativas se describen con valores relativos. Se realzó análisis comparativo por estado de peso. Se respetaron aspectos éticos según la reglamentación vigente. Resultados: La edad promedio 9.1 años, índice de masa corporal promedio 17.8 kg/m2, porcentaje de grasa corporal promedio 20%. El 38.7%  de los escolares presentó sobrepeso u obesidad. La presión sistólica y diastólica promedio fue 93/60mmHg. Niños con sobrepeso y obesidad más riesgo de cifras de presión sistólica y diastólica alteradas. Estilos de vida y consumo de macronutrientes mostraron promedio de 64.1 y 39.5 y no influyeron en el porcentaje de grasa corporal. Discusión y Conclusiones: Los resultados sugieren incluir el uso de mediciones mas objetivas de los estilos de vida, y resaltan la importancia de abordar eficientemente la problemática del sobrepeso y obesidad y disminuir riesgo de desarrollar enfermedades crónicas a temprana edad.Cómo citar este artículo: Ruiz E, Bañuelos Y, Bañuelos P, Álvarez A, Valles MM, Domínguez CJ. Porcentaje de grasa corporal en escolares y su asociación con el estilo de vida y macronutrientes. Rev Cuid. 2015; 6(2: 1022-8. http://dx.doi.org/10.15649/cuidarte.v6i2.150

Infección por HTLV-1 y HIV en pacientes con herpes zoster en Perú

Directory of Open Access Journals (Sweden)

Sandra Delgado

2011-07-01

Full Text Available Objetivos: Determinar la frecuencia de infección por el virus linfotrópico humano tipo 1 (HTLV-1 y VIH en pacientes con herpes zoster. Material y métodos: Estudio prospectivo observacional realizado entre agosto de 2005 y agosto de 2006. Se incluyeron pacientes adultos con diagnóstico de herpes zoster atendidos en los diferentes servicios del Hospital Nacional Cayetano Heredia. Un cuestionario de características clínicas y factores de riesgo asociados con infección por HTLV-1 y VIH fue completado previo a la toma de muestra. Se excluyeron los pacientes con resultados positivos previos para HTLV-1 y HIV. Resultados: Se incluyeron 44 pacientes, la edad promedio fue 48,1 ± 19,5; 24/44 (55% fueron mujeres. Infección solo por VIH se encontró en 4/44 (9% pacientes, todos menores de 35 años, mientras que infección solo por HTLV-1 se encontró en 2/44 (5% pacientes, todas mujeres mayores de 50 años. Un caso de infección dual fue encontrado en una mujer de 56 años. La tasa de infección por HTLV-1 fue 25% (3/12 en mujeres mayores de 50 años con compromiso de múltiples dermatomas. Conclusiones: En nuestro escenario, la infección por HTLV-1 es ligeramente mas frecuente en mujeres mayores de 50 años con herpes zoster. Por ello, el despistaje de HTLV-1 debe ser recomendado en este grupo etario, mientras que el despistaje de VIH es aún particularmente importante en pacientes jóvenes.(Rev Med Hered 2011;22:98-102.

Ceļu satiksmes drošības direkcijas (CSDD) sociālo reklāmas kampaņu klipu semiotiskā analīze (2003. - 2013.)

OpenAIRE

Lapinska, Ginta

2014-01-01

Bakalaura darba tēma ir „Ceļu satiksmes drošības direkcijas (CSDD) sociālo reklāmas kampaņu klipu semiotiskā analīze (2003. - 2013.)”. CSDD reklāmas gadu gaitā ir pārliecinājušas reklāmas industriju un auditoriju, tāpēc būtiski ir noskaidrot, kādi ir izmantotie semiotiskie elementi un kā to izmantojums gadu gaitā ir mainījies. Darba mērķis ir izpētīt vienojošos semiotiskos elementus CSDD reklāmas kampaņu klipos no 2003.-2013. gadam. Teorētiskajā daļā aplūkotas tēmas: reklāmas, kampaņas ...

Remote Sensing of Radiative and Microphysical Properties of Clouds During TC (sup 4): Results from MAS, MASTER, MODIS, and MISR

Science.gov (United States)

King, Michael D.; Platnick, Steven; Wind, Galina; Arnold, G. Thomas; Dominguez, Roseanne T.

2010-01-01

The Moderate Resolution Imaging Spectroradiometer (MODIS) Airborne Simulator (MAS) and MODIS/Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) Airborne Simulator (MASTER) were used to obtain measurements of the bidirectional reflectance and brightness temperature of clouds at 50 discrete wavelengths between 0.47 and 14.2 microns (12.9 microns for MASTER). These observations were obtained from the NASA ER-2 aircraft as part of the Tropical Composition, Cloud and Climate Coupling (TC4) experiment conducted over Central America and surrounding Pacific and Atlantic Oceans between 17 July and 8 August 2007. Multispectral images in eleven distinct bands were used to derive a confidence in clear sky (or alternatively the probability Of cloud) over land and ocean ecosystems. Based on the results of individual tests run as part of the cloud mask, an algorithm was developed to estimate the phase of the clouds (liquid water, ice, or undetermined phase). The cloud optical thickness and effective radius were derived for both liquid water and ice clouds that were detected during each flight, using a nearly identical algorithm to that implemented operationally to process MODIS Cloud data from the Aqua and Terra satellites (Collection 5). This analysis shows that the cloud mask developed for operational use on MODIS, and tested using MAS and MASTER data in TC(sup 4), is quite capable of distinguishing both liquid water and ice clouds during daytime conditions over both land and ocean. The cloud optical thickness and effective radius retrievals use five distinct bands of the MAS (or MASTER), and these results were compared with nearly simultaneous retrievals of marine liquid water clouds from MODIS on the Terra spacecraft. Finally, this MODIS-based algorithm was adapted to Multiangle Imaging SpectroRadiometer (MISR) data to infer the cloud optical thickness Of liquid water clouds from MISR. Results of this analysis are compared and contrasted.

Who bears the burden of international taxation? Evidence from cross-border M&As

NARCIS (Netherlands)

Huizinga, H.P.; Voget, J.; Wagner, W.B.

2012-01-01

Cross-border M&As can trigger additional taxation of the target's income in the form of non-resident dividend withholding taxes and acquirer-country corporate income taxation. This paper finds that this additional international taxation is fully capitalized into lower takeover premiums. In contrast,

Epilepsia de la infancia con paroxismos occipitales

Directory of Open Access Journals (Sweden)

Albia Pozo Alonso

1999-09-01

Full Text Available Se reporta que la epilepsia de la infancia con paroxismos occipitales constituye un síndrome epiléptico muy bien definido; se incluye en el grupo de las epilepsias idiopáticas relacionadas con localización. Los ataques comienzan habitualmente con síntomas visuales, en ocasiones seguidos por ataques hemiclónicos, parciales complejos y tónicoclónicos generalizados. El electroencefalograma interictal muestra complejos de puntaonda de localización occipital y temporal posterior que desaparecen con la apertura de los ojos. Se presenta una paciente de 8 años de edad que reúne los criterios clínicos y electroencefalográficos de la epilepsia de la infancia con paroxismos occipitales y se enfatiza en la evolución supuestamente benigna de dicho síndrome.Is is reported that epilepsy of childhood with occipital paroxysms is an epileptic syndrome that is well defined. It is included in the group of related idiopathic epilepsies with localization. Seizures habitually begin with visual symptoms, which are ocassionally followed by hemiclonic, complex partial, and generalized tonicclonic seizures. The interictal EEG shows spike-wave complexes of occipital and temporal posterior localization that are suppressed by eye opening. A patient aged 8 in whom the clinical and electroencephalographic criteria of epilepsy of childhood with occipital paroxysms are present is studied in this paper. Emphasis is made on the apparently benign evolution of this syndrome.

Veikala „Dīvāni un Dīvāni” reklāmas analīze un pilnveidošanas iespējas.

OpenAIRE

Alsiņa, Madara

2013-01-01

Bakalaura darba tēma „Veikala „Dīvāni un Dīvāni” reklāmas analīze un pilnveidošanas iespējas”. Bakalaura darba mērķis ir, pamatojoties uz teorijā gūtajām atziņām par reklāmu, izanalizēt veikala „Dīvāni un Dīvāni” reklāmas pasākumus, to stiprās un vājās puses, novērtēt reklāmas komunikatīvo efektivitāti, kā arī izstrādāt priekšlikumus veikala „Dīvāni un Dīvāni” reklāmas pilnveidošanai. Pirmajā darba daļā tiek apskatīti reklāmas kā mārketinga komunikāciju elementa teorētiskie aspekti – ...

Klientu attiecību pārvaldības sistēmas izveide autoservisam

OpenAIRE

Jaunzems, Ģirts

2012-01-01

Diplomdarba tēma ir Klientu attiecību pārvaldības sistēmas izveide autoservisam. Tā mērķis ir izstrādāt un ieviest pielāgotu klientu attiecību pārvaldības sistēmu nelielam autoservisam, tādējādi atvieglojot klientu un viņu darbības vēstures uzskaiti. Lai sasniegtu diplomdarba mērķi, darba autors izpētīja teorētiskos informācijas avotus, salīdzināja divas klientu pārvaldības sistēmas, kā arī izstrādāja sistēmu konkrētam uzņēmumam, veicot arī tās izmaksu analīzi. Diplomdarbā ir secināts, ...

Bacteriemia en pacientes internados con celulitis

Directory of Open Access Journals (Sweden)

Juan S. Lasa

2012-08-01

Full Text Available La celulitis es una inflamación aguda de la dermis y tejido celular subcutáneo de causa bacteriana, que generalmente complica a heridas, úlceras y dermatosis, aunque de manera frecuente no existe sitio de entrada. Se recomienda la realización de cultivo de punción de piel y partes blandas (PPB. Los hemocultivos raramente dan resultados positivos. El objetivo de este trabajo fue determinar la prevalencia de bacteriemia en pacientes internados en nuestra institución con diagnóstico de celulitis. Se analizaron retrospectivamente los registros clínicos de los pacientes con este diagnóstico al ingreso entre junio de 2007 y marzo de 2010. Se evaluaron los datos poblacionales, presencia de comorbilidades, y resultados de los cultivos. En ese período, se internaron 140 pacientes con diagnóstico de celulitis y a todos ellos se les realizó hemocultivo y cultivos de PPB. Setenta y cuatro eran varones (52.8%. La edad promedio: 47.5 ± 19.7 años (rango 16-94. El 40% tuvo cultivos positivos de PPB, en los que el Staphylococcus aureus meticilino resistente (SAMR fue el germen más frecuentemente aislado (35.7%; la prevalencia de bacteriemia fue del 8.6%, en donde el germen más frecuente fue Streptoccocus Beta hemolítico, grupo G (33% del total de hemocultivos positivos. La bacteriemia se asoció significativamente a mayor estadía hospitalaria (10.5 ± 8.9 vs. 4.9 ± 6, p = 0.004. Se asoció con mayor riesgo de hemocultivo positivo a ser diabético, tener cultivo de PPB positivo, consumo de alcohol y/o enfermedad pulmonar obstructiva crónica.

Calcificaciones metastásicas en un paciente con insuficiencia renal crónica en diálisis peritoneal

Directory of Open Access Journals (Sweden)

Magali Rodríguez Vidal

2013-09-01

Full Text Available La enfermedad renal crónica implica un proceso irreversible en la reducción del funcionamiento del tejido renal por lo que la ha llevado a ser un problema de carácter epidémico, donde las complicaciones son devastadoras para la calidad de vida en el paciente, dentro de éstas destacan las calcificaciones metastásicas que se producen por la retención de fósforo, disminución de los niveles de calcio y aumento de la paratohormona. El tratamiento mas adecuado es la paratiroidectomia subtotal con autoimplante, donde la sintomatología y la progresión de las alteraciones del metabolismo mineral se reduce y mejora el estado general del paciente. Se presenta un caso clínico de una paciente en diálisis peritoneal, con diagnóstico de calcificación metastásica abdominal, a la cual se le realiza una paratiroidectomia - subtotal con autoimplante, donde se observó una buena respuesta con disminución de la calcificación en forma progresiva. Al evaluar el caso clínico proponemos como enfermeras especialistas en el cuidado del paciente renal, establecer en los centros de diálisis un control semestral por enfermera, independiente de las sesiones de diálisis, donde podamos pesquisar con mayor privacidad y autonomía, las necesidades particulares de cada uno de estos pacientes contribuyendo precozmente a una mejor adherencia al tratamiento y retardo progresivo de las complicaciones propias de esta enfermedad.

KEBIJAKAN INVESTASI ASING BIDANG PERTAMBANGAN DI KABUPATEN POHUWATO PROVINSI GORONTALO KEBIJAKAN INVESTASI ASING BIDANG PERTAMBANGAN DI KABUPATEN POHUWATO PROVINSI GORONTALO KEBIJAKAN INVESTASI ASING BIDANG PERTAMBANGAN DI KABUPATEN POHUWATO PROVINSI GORONTALO KASUS PT. PANI DHARMA MAS KASUS PT. PANI DHARMA MAS KASUS PT. PANI DHARMA MAS

OpenAIRE

PUYO, AJENG MAWADDAH PUYO AJENG MAWADDAH PUYO AJENG MAWADDAH

2016-01-01

2016 AJENG MAWADDAH PUYO, E 131 12 003, "Kebijakan Investasi Asing Dalam Bidang Pertambangan di Kabupaten Pohuwato Provinsi Gorontalo Kasus PT. Pani Dharma MAS", dibawah bimbingan Dr. H. Adi Suryadi B., MA selaku pembimbing I dan Pusparida Syahdan. S.sos., MSI, Departemen Ilmu Hubungan internasional, Fakultas Ilmu Sosial dan Ilmu Politik, Universitas Hasanuddin. Penelitian ini bertujuan untuk mengetahui peran stakeholders dalam perumusan kebijakan investasi asing da...

Acceptance Test Report for the Modular Automation System (MAS) Manufactured by Honeywell Inc

International Nuclear Information System (INIS)

ANDERSON, D.L.

2000-01-01

This document details the performance of the acceptance test of the Honeywell MAS Control System for equipment to be installed in gloveboxes HA-20MB and HA-211 at a later date. Equipment that was anticipated included 6 stabilization furnaces, only three and their associated equipment were installed

Segundo Catálogo Estelar del Hemisferio Sur con Astrolabio Fotoeléctrico PAII

Science.gov (United States)

Manrique, W. T.; Podestá, R. C.; Alonso, E.; Actis, E. V.; Pacheco, A. M.; Bustos, G.; Lizhi, L.; Zezhi, W.; Fanmiao, Z.; Hongqi, W.; Perdomo, R.

Recordamos que entre el Observatorio Astronómico ``Félix Aguilar'', el Observatorio Astronómico de Beijing y el Observatorio Astronómico de La Plata, se ha convenido en desarrollar un Proyecto de Investigación conjunto, para la observación sistemática de estrellas en el Hemisferio Sur, con el objeto de la elaboración de un Catálogo Estelar Global utilizando un Astrolabio Fotoeléctrico PAII del Observatorio de Beijing, que ha sido usado con éxito en la República de China. En este trabajo se presenta el Segundo Catálogo Estelar del Hemisferio Sur, derivado de las observaciones realizadas con el PAII instalado en el OAFA, durante el períiodo Febrero de 1992 a Marzo de 1997. En este lapso se han observado mas de 400000 pasajes estelares, obteniéndose las correcciones Δ α y Δ δ de 5241 estrellas del FK4, FK5, FK5 Ext., SRS, CAMC y GC. Las precisiones medias son del orden de ± 3,2 ms en ascensión recta y ±0."057 en declinación. Rango de magnitudes : 2,0 a 11,5 Rango de declinaciones : -3o a -60o Epoca Media : 1994.9 Se analizan los residuos en función de la magnitud y tipo espectral, correcciones de grupo y frecuencia de distribución Δ α y Δ δ.

Poblaciones linfocitarias, células dendríticas y perfil de citoquinas en ratones con melanoma tratados con Uncaria tomentosa

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Iván Lozada-Requena

Full Text Available Objetivos. Evaluar el efecto inmunomodulador sobre poblaciones linfocitarias, células dendríticas (DC, citoquinas Th1/Th2/Th17 (T-helper e inflamatorias en el ámbito sistémico y/o en el microambiente tumoral de ratones con o sin melanoma. Materiales y métodos. Se obtuvieron muestras de sangre periférica y/o de tumores primarios de ratones con melanoma B16 tratados o no con un extracto hidroalcohólico de Uncaria tomentosa (UT con 5,03% de alcaloides oxindólicos pentacíclicos (UT-POA obtenido de la corteza de la planta. Todos los ensayos de medición de células y citoquinas fueron realizados por citometría de flujo. Resultados. UT-POA a nivel sistémico incrementa la relación CD4/CD8a (Cluster of Differenciation, mientras que la activación celular es inversamente proporcional; incrementa la proporción de DCm (DC mieloides; induce un perfil Th1 proinflamatorio y reduce la respuesta Th17. TNF-a (tumor necrosis factor alpha y IL-17A (interleuquina correlacionan positiva y negativamente con la relación CD4/CD8a. Conclusiones. El incremento de Th1 (TNF-a puede tener como consecuencia el incremento de linfocitos CD4 o la activación de macrófagos M1. Aunque UT-POA muestra un incremento de DCm, este no es dosis-dependiente. La disminución de Th17 (IL-17A puede favorecer el funcionamiento de los linfocitos CD8a. UT-POA muestra mejores efectos inmunomoduladores en el ámbito sistémico que intratumoral

Genotoxic activity of 4,4',5'-trimethylazapsoralen on plasmid DNA.

Science.gov (United States)

Lagatolla, C; Dolzani, L; Granzotto, M; Monti-Bragadin, C

1998-01-01

The genotoxic activities of 8-methoxypsoralen (8-MOP) and 4,4',5'-trimethylazapsoralen (4,4',5'-TMAP) on plasmid DNA have been compared. In a previous work, 4,4',5'-TMAP, a methyl derivative of a psoralen isoster, had shown potential photochemotherapeutic activity. The mutagenic activity of mono- and bifunctional lesions caused by these compounds was evaluated both after UVA irradiation, which causes the formation of both kinds of lesions, and after a two-step irradiation procedure of the psoralen-plasmid DNA complex, which allowed monoadducts and interstrand crosslinks to be studied separately. Furthermore, we used a procedure that allowed us to evaluate both the mutagenic and recombinogenic activity of the two compounds. Results indicate that the most important difference between 8-MOP and 4,4',5'-TMAP consists in their mode of photoreaction with DNA rather than in their mutagenic potential. In fact, in all of the experimental procedures, 4,4',5'-TMAP shows a lower ability than 8-MOP to generate interstrand crosslinks. However, when comparable toxicity levels are reached, the two compounds show the same mutagenic potentiality.

Respuesta reproductiva de ovejas de pelo sincronizadas con progesterona o prostaglandinas

OpenAIRE

Arroyo-Ledezma, Jaime; De La Torre-Barrera, Jannette; Ávila-Serrano, N. Ysac

2013-01-01

La sincronización ajusta los estros a tiempos específicos y permite usar tecnologías reproductivas. El objetivo de este estudio fue evaluar la respuesta reproductiva de 30 ovejas de pelo sincronizadas con progesterona (P4) o prostaglandinas. Las ovejas de pelo eran 5/8 Pelibuey x 2/8 Black Belly x 1/8 Dorper, de 3.5 a 4.0 años de edad, con peso promedio de 37.8 ±3.0 kg; el último parto fue 8 meses previos al experimento. Los tratamientos fueron; 1) aplicación por 11 d de 300 mg de P4 impregna...

FORTIFICACIÓN DE PULPA DE UCHUVA CON CALCIO, OLIGOFRUCTOSA Y VITAMINA C, ESTABILIZADA CON HIDROCOLOIDE

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ALBA LUCIA DUQUE

2014-06-01

Full Text Available La pulpa de uchuva fortificada con calcio, oligofructosa y vitamina C es un alimento funcional con grandes beneficios para la salud. Para ello se le adicionó componentes biológicamente activos, como ácidos grasos, fibra alimentaria y antioxidantes. En este trabajo se estudió la estabilidad de la pulpa enriquecida en diferentes formulaciones, teniendo en cuenta los criterios de incorporación de calcio y vitamina C (20% del valor diario recomendado VDR y para la oligofructosa (fibra dietaría en relación 1:1 con el calcio. Los resultados obtenidos mostraron que la pulpa de uchuva fortificada con CMC, ologofructosa, calcio y vitamina C presentó en promedio una estabilidad de 87,7±10,0; una viscosidad de 22,8±7,9; una aw de 0,9863±0; pH de 3,3±0,1; acidez de 1,6±0,1; grados Brix de 13,3±0,7; una densidad de 1,32±0 g/mL y las mejores respuestas sensoriales en cuanto a color, aroma, fluidez y sabor.

Anomalous H/D isotope effect on 35Cl NQR frequencies and H/D isotope effect on 1H MAS NMR spectra in pyrrolidinium p-chlorobenzoate

International Nuclear Information System (INIS)

Nakano, Ryo; Honda, Hisashi; Nakata, Eiichi; Takamizawa, Satoshi; Noro, Sumiko; Kimura, Taiki; Kyo, Shin-shin; Ishimaru, Shin'ichi; Miyake, Ryosuke

2010-01-01

An anomalous isotope effect was observed in the 35 Cl NQR frequency of pyrrolidinium p-chlorobenzoate (C 4 H 8 NH 2 + ·ClC 6 H 4 COO - ) by deuterium substitution of hydrogen atoms which form two kinds of N-H...O type hydrogen bonds. Large negative frequency shifts of the 35 Cl resonance lines, reaching 309 kHz at 77 K and 267 kHz at 293 K, were obtained upon deuteration, although the Cl atom in the molecule formed no hydrogen bonds in the crystal. 1 H MAS NMR lines showed significant changes by the deuterium substitution, while in contrast, small shifts of 13 C CP/MAS NMR signals were obtained. Our measurements of 1 H NMR spin-lattice relaxation times (T 1 ) suggested that the H/D isotope shifts detected from the 35 Cl NQR frequencies and 1 H NMR spectra are due to structural changes rather than molecular dynamics. Single-crystal X-ray diffraction measurements showed two remarkable H/D isotope differences in the molecular arrangements, (1) the N-H length along the crystallographic a axis became 1 pm shorter, and (2) the dihedral angle between benzene and the pyrrolidine ring changed by 1.1(2)deg upon deuteration. Using density functional theory estimations, the anomalous 35 Cl NQR frequency shifts and 1 H MAS NMR line-shape changes could be explained by the dihedral angle change rather than the N-H length difference. (author)

Variable temperature 127I MAS NMR of β-AgI

International Nuclear Information System (INIS)

Wagner, G.W.

1991-01-01

Variable temperature 127 I MAS NMR of β-AgI powder, measured from 123 to 413 K is sensitive to Ag + diffusion through the iodine lattice. In low temperature spectra, the iodine ions appear to be in nearly static environments in agreement with the low temperature crystal structure. However, at higher temperatures, substantial broadening of the central transition linewidth is consistent with the presence of two types of Ag + diffusion with activation energies of 0.17 and 0.0080 eV. (author). 15 refs.; 5 figs.; 1 tab

Resección hepática asistida con radiofrecuencia bipolar: primeras experiencias con el Surtron SB

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José Luis González González

Full Text Available Las resecciones primarias y secundarias del hígado tienen como uno de sus mayores dilemas el sangrado transoperatorio. La introducción de los equipos de radiofrecuencia, en particular el Surtron SB, comienza a dar resultados alentadores. Se presentan las primeras 8 experiencias cubanas con resecciones menores y mayores realizadas con este equipo. Siete de estos pacientes tenían metástasis y uno un hepatocarcinoma. Se practicaron 2 resecciones regladas y 6 atípicas, durante las cuales no hubo complicaciones y solo un paciente necesitó transfusión sanguínea.

preescolares desnutridos con madres con obesidad y sin obesidad

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Viridiana Vanessa Conzuelo-González

2009-01-01

Full Text Available El primer objetivo fue conocer cuántos menores de cinco años con diferentes grados de desnutrición tienen una madre con sobrepeso/obesidad/ en una comunidad indígena que vive en extrema pobreza y bajo condiciones de migración masculina internacional. El segundo fue comparar tres variables socionutricionales (ingreso familiar, educación de la madre y adecuación nutrimental de la dieta diaria entre estos hogares y los hogares con desnutrición infantil y madres sin obesidad. Se realizó un estudio transversal (2006-2007, en la comunidad mazahua de San Francisco Tepeolulco, Municipio de Temascalcingo; que incluyó a 85 hogares integrados por preescolares con desnutrición inscritos al programa Oportunidades. Se determinó el estado nutrición de los preescolares con indicadores antropométricos y se obtuvo el IMC de las madres de estos infantes. Se aplicó una encuesta socionutricional, incluida el recordatorio de 24 horas, y complementado con la observación participante (cualitativa. Se encontró que 83% de las madres mazahuas presentaron sobrepeso u obesidad. El estado de nutrición de los preescolares con madres con obesidad presentó un porcentaje mayor de desnutrición (76%. En la variable género, se encontró que 54% de los niños con madres con obesidad tenía baja talla. Al relacionar el nivel educativo de la madre, esta variable resultó ser estadísticamente significativa (p=0.015, donde el analfabetismo está más relacionado con la desnutrición infantil que tienen madres de bajo y/o peso normal. La elevada prevalencia de hogares conformados con preescolares con desnutrición y madres con obesidad, es un síntoma más de la pobreza en zonas indígenas en México, con bajo índice de desarrollo humano.

Evaluación del estres oxidativo en pacientes con malaria

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Margarita Zuleta

2000-02-01

Full Text Available

8.5pt; font-family: Arial">El estrés oxidativo se define como un imbalance entre la generación de especies reactivas del oxígeno y la cantidad de enzimas y compuestos antioxidantes.

8.5pt; font-family: Arial">En malaria, el estrés oxidativo se presenta con la generación aumentada de especies reactivas del oxígeno como anión superóxido, peróxido de hidrógeno, radical hidroxilo y peroxinitrito; éstas son producidas por el sistema inmune del hospedero con el objetivo de controlar la parasitemia y directamente por el parásito intraeritrocítico, cuando en la vacuola digestiva transforman la hemoglobina en metahemoglobina. La producción de especies reactivas del oxígeno en malaria se ha demostrado por la peroxidación lipídica en eritrocitos infectados con plasmodium durante la fase aguda de la infección, determinada por métodos indirectos como el incremento en los niveles del ácido tiobarbitúrico en eritrocitos infectados o por el incremento en los niveles de malondialdehido en pacientes con malaria cerebral y por la disminución en la cadena de ácidos grasos poliinsaturados en los eritrocitos infectados.

8.5pt; font-family: Arial">El estrés oxidativo en malaria también se presenta con la disminución de enzimas y sustancias antioxidantes como la albúmina, el tocoferol plasmático, los niveles de enzimas como catalasa, glutatión peroxidasa y superóxido dismutasa en pacientes con malaria tanto causado por P. vivax como por P. falciparum. El estrés oxidativo en malaria se ha asociado con complicaciones como la malaria cerebral, porque las especies reactivas del oxígeno están involucradas en el daño del endotelio vascular del hospedero y con altas parasitemias en pacientes infectados con P. falciparum.

8.5pt; font-family: Arial

MAS-based Distributed Coordinated Control and Optimization in Microgrid and Microgrid Clusters: A Comprehensive Overview

DEFF Research Database (Denmark)

Han, Yang; Zhang, Ke; Hong, Li

2018-01-01

The increasing integration of the distributed renewable energy sources highlights the requirement to design various control strategies for microgrids (MGs) and microgrid clusters (MGCs). The multi-agent system (MAS)-based distributed coordinated control strategies shows the benefits to balance...... the power and energy, stabilize voltage and frequency, achieve economic and coordinated operation among the MGs and MGCs. However, the complex and diverse combinations of distributed generations in multi-agent system increase the complexity of system control and operation. In order to design the optimized...... configuration and control strategy using MAS, the topology models and mathematic models such as the graph topology model, non-cooperative game model, the genetic algorithm and particle swarm optimization algorithm are summarized. The merits and drawbacks of these control methods are compared. Moreover, since...

Inducción fúngica de la biorremediación de suelos contaminados con combustibles

Directory of Open Access Journals (Sweden)

Mary Lopretti

2011-04-01

Full Text Available La biorremediación de suelos ha sido en los últimos años una de las aplicaciones de los procesos de la biotecnología industrial que se ha desarrollado en busca de soluciones  naturales y eficientes al problema de la contaminación.Varios son los microorganismos que viven en condiciones extremas, desarrollando estrategias metabólicas que les permiten tener sus vías metabólicas aptas para vivir y reproducirse. Dentro de estas estrategias  se encuentra la acción de enzimas hidrolíticas, oxidativas y depolimerizantes que permiten modificar sustratos complejos como lo son los derivados del petróleo  y entre ellos los combustibles.En el presente trabajo se estudió la acción de dos hongos Gloeophylum trabeum y Phanerochaetes chrysosporium actuando en forma consorcial sobre sustratos  contaminados con gasoil y nafta.Se prepararon 4 reactores de fermentación sólida: dos de ellos blanco, contaminados sin inducción, y de los otros dos uno con nafta y el otro con gasoil inoculados ambos con 100cc de medio de propagación con micelios de P.chrysosporium y 50cc de medio de crecimiento con pellets de G. trabeum. Se extrajeron muestras cada 15 días y se evaluó  en el material de cada reactor características fisicoquímicas como %C, humedad y pH.También se realizó la evaluación microbiológica por siembra en placa y dilución en placa con agar malta al 1,25%. En todos los casos se obtuvieron micelios.Por último se determinó la actividad de enzimas lacasa  y peroxidasa. La actividad lacasa se determinó por espectrometría usando 0.5mM de ABTS como sustrato en 0,1M de buffer acetato de sodio pH5 y 1 ml de extracto obtenido por extracción salina. La determinación de actividad Mn peroxidasa se realizó con 0.01% de rojo fenol como sustrato en buffer succinato de sodio 0.1M en presencia de 1 ml de extracto enzimático, MnSO4 0.1M y H2O2 0.1M.Las actividad  de éstas enzimas permitió obtener moléculas mas pequeñas producto de la

Tratamento de uma coorte de pacientes com infarto agudo do miocárdio com supradesnivelamento do segmento ST Tratamiento de una cohorte de pacientes con infarto agudo de miocardio con supradesnivel del segmento ST Treatment of a cohort of patients with acute myocardial infarction and ST-segment elevation

Directory of Open Access Journals (Sweden)

Jamil da Silva Soares

2009-06-01

Full Text Available FUNDAMENTO: Trombólise e angioplastia transluminal coronariana (ATC primária são técnicas bem estabelecidas, mas grande parte dos pacientes com infarto agudo do miocárdio com supradesnivelamento do segmento ST (IAM com SST não as recebem quando do atendimento hospitalar. OBJETIVO: Descrever tratamentos inicial e final e desfechos de uma coorte com IAM com SST. MÉTODOS: Analisados, da internação até a alta, 158 pacientes com IAM com SST, de uma população total de 351 pacientes internados com (SCA nos hospitais de Campos dos Goytacazes, entre 2004 e 2006. RESULTADOS: Dos 158 pacientes com IAM com SST, 67,7% chegaram ao hospital nos primeiros 180 minutos, 81,3% em 360 minutos e 8,4% após doze horas. Realizados 148 estudos cinecoronariográficos (93,7%. Observadas lesões de mais de 70% em 266 territórios arteriais. Tratamento inicial foi ATC em 41(26%, trombolíticos em 50 (32%, com 80% de sucesso. Tratamento clínico em 67 (42%. Cerca de 35% dos pacientes deveriam ser trombolizados mas não o foram. No tratamento final foram 93 ATCs, 89 delas com sucesso angiográfico (95,7, sangramento 2 (2,2, oclusão subaguda 2 (2,2%, dissecção tronco 1 (1,1, pseudo aneurisma 1 (1,1. Nenhum óbito durante angioplastia; na evolução, houve dois óbitos (2,1%. Doze pacientes submetidos a cirurgia de revascularização miocárdica (CRM. Tratamento clínico 53 (33%, com 11 óbitos (20,7%. Letalidade global 9,5%, consideradas as três formas de tratamento. CONCLUSÃO: Pacientes atendidos em tempo adequado para reperfusão, porém 1/3 deles não recebeu o procedimento. Tratamento predominante foi ATC, com baixa morbidade. Dois óbitos na evolução. Baixa letalidade global.FUNDAMENTO: La trombólisis y la angioplastia transluminal coronaria (ATC primaria son técnicas bien establecidas, sin embargo gran parte de los pacientes con infarto agudo de miocardio con supradesnivel del segmento ST (IAM con SST no las reciben cuando de la atenci

The MAS Six Years in Power in Bolivia

Directory of Open Access Journals (Sweden)

Ton Salman

2012-04-01

Full Text Available Review Essay of:– The Rise of Evo Morales and the MAS, by Sven Harten. London/New York: Zed Books, 2011.– Evo Morales and the Movimiento al Socialismo in Bolivia; The First Term in Context, edited by Adrian J. Pearce. London, Institute for the Study of the Americas, 2011.– El estado de derecho como tiranía, by Luis Tapia. La Paz: CIDES/UMSA, 2011.– From Rebellion to Reform in Bolivia: Class Struggle, Indigenous Liberation and the Politics of Evo Morales, by Jeffery R. Webber. Chicago: Haymarket Books, 2011.– La democracia desde los márgenes: Transformaciones en el campo político boliviano, by María Teresa Zegada, with Claudia Arce, Gabriela Canedo and Alber Quispe. La Paz: Muela del Diablo Editores/CLACSO, 2011.

Multi-Robot Remote Interaction with FS-MAS

Directory of Open Access Journals (Sweden)

Yunliang Jiang

2013-02-01

Full Text Available The need to reduce bandwidth, improve productivity, autonomy and the scalability in multi-robot teleoperation has been recognized for a long time. In this article we propose a novel finite state machine mobile agent based on the network interaction service model, namely FS-MAS. This model consists of three finite state machines, namely the Finite State Mobile Agent (FS-Agent, which is the basic service module. The Service Content Finite State Machine (Content-FS, using the XML language to define workflow, to describe service content and service computation process. The Mobile Agent computation model Finite State Machine (MACM-FS, used to describe the service implementation. Finally, we apply this service model to the multi-robot system, the initial realization completing complex tasks in the form of multi-robot scheduling. This demonstrates that the robot has greatly improved intelligence, and provides a wide solution space for critical issues such as task division, rational and efficient use of resource and multi-robot collaboration.

Indicadores de enfermedades mentales en pacientes mexicanos con VIH/SIDA y su relación con la adherencia terapéutica

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Ismael García-Cedillo

2011-01-01

Full Text Available Objetivo. Se analiza la relación entre algunos indicadores de enfermedades mentales y la adherencia terapéutica en pacientes con VIH/SIDA. Participantes. Muestra de 76 pacientes mexicanos infectados por VIH/SIDA. Procedimiento. Entrevista a profundidad a pacientes de un hospital público de la ciudad de San Luis Potosí, México. Resultados. 80% de los participantes presentó indicadores de enfermedades mentales correspondientes a: 28% conducta antisocial; 20% depresión clínica; 13% síndrome de estrés postraumático, 12% psicosis orgánica y 8% discapacidad intelectual. El porcentaje de pacientes infectados con VIH/SIDA con indicadores de enfermedad mental concuerda con los resultados de investigaciones realizadas en otros países. Solamente 7% de los participantes mostró un nivel de adherencia apropiado. La adherencia no guarda una relación lineal con la presencia de indicadores de enfermedad mental. La adherencia se relaciona con la escolaridad, la utilización de estrategias para recordar la toma del medicamento, confiar el estatus a los familiares y apoyo familiar.

Isolation of Methoxyfuranocoumarins From Ammi majus by Centrifugal Partition Chromatography.

Science.gov (United States)

Bartnik, Magdalena; Mazurek, Anna Katarzyna

2016-01-01

Pure methoxyfuranocoumarins were isolated from Ammi majus L. by use of low-pressure column chromatography (LPCC) followed by centrifugal partition chromatography (CPC). The concentrated petroleum ether extract from fruits of A. majus was fractionated on a silica gel column using a gradient of ethyl acetate in dichloromethane (0-80%, v/v). Coumarin-rich fractions were analyzed by thin-layer chromatography (TLC) and high-performance liquid chromatography with diode array detection (HPLC/DAD). Xanthotoxin (8-MOP) and isopimpinellin (isoP), structurally similar compounds, were isolated in one fraction (FR6). To avoid multistep and long-lasting TLC preparation, optimization of CPC conditions has been performed. In one run, an effective separation of 8-MOP and isoP was achieved. The two-phase solvent system composed of n-hexane-ethyl acetate-methanol-water (10 : 8 : 10 : 9; v/v) in an ascending mode (the aqueous phase was a stationary phase, and the organic phase was a mobile phase), with flow rate 3 mL/min and rotation speed 1,600 r.p.m., was used. The identification and high purities of isolated 8-MOP (98.7%) and isoP (100%) were confirmed by HPLC/DAD assay, when compared with standards. The developed CPC method could be applied to the effective isolation of 8-MOP and isoP from plant extracts. The high purity of obtained compounds makes possible further exploitation of these components in biological studies. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Antimicrobial effects of phototherapy and photochemotherapy in vivo and in vitro

International Nuclear Information System (INIS)

Yoshimura, M.; Namura, S.; Akamatsu, H.; Horio, T.

1996-01-01

We investigated the antimicrobial effects of phototherapy and photochemotherapy in vivo and in vitro. First, Staphylococcus aureus samples were obtained using stamp agar medium from inflammatory lesions of 29 adult patients with atopic dermatitis before and after a single photochemotherapy. Therapy was oral PUVA (30 mg 8-methoxypsoralen, 8MOP plus 5 J/cm 2 UVA), topical PUVA (0.3% 8MOP plus 200 mJ/cm 2 UVA) or UVB (80 mJ/cm 2 ) irradiation. The number of S. aureus on the lesions was significantly reduced, even after a single treatment with all therapies. Reductions (mean ± SD) were 69.3 ± 26.9%, 76.3 ± 31.3% and 83.8 ± 18.5%, respectively. Secondly, we investigated the effect of PUVA (0.001% 8MOP plus 10, 20, 30, 40, or 50 mJ/cm 2 UVA) and UVB (10, 30, 50, or 100 mJ/cm 2 ) irradiation on the proliferation of S. aureus in vitro. PUVA and UVB treatment markedly inhibited the proliferation in a dose-dependent manner. These results seem to indicate the possibility that the antimicrobial effect of UV radiation contributes to successful photochemotherapy in patients with atopic dermatitis. (Author)

Desafío con wssv bajo fluctuaciones de temperatura

OpenAIRE

Sonnenholzner, Stanislaus

2002-01-01

Desafío con WSSV bajo fluctuaciones de temperatura En trabajos anteriores sobre el efecto de la temperatura del agua sobre la supervivencia del camarón infectado con el virus de la Mancha Blanca, se demostró que una temperatura constante de 33ºC por 8 días genera una respuesta inmune en el camarón correlacionada a una supervivencia superior al 90%, lo cual se tradujo posteriormente en una propuesta práctica de cultivo de camarón en estanques con invernaderos, actualmente en evaluación e...

Angiotensin (1-7) ameliorates the structural and biochemical alterations of ovariectomy-induced osteoporosis in rats via activation of ACE-2/Mas receptor axis.

Science.gov (United States)

Abuohashish, Hatem M; Ahmed, Mohammed M; Sabry, Dina; Khattab, Mahmoud M; Al-Rejaie, Salim S

2017-05-23

The local and systemic renin angiotensin system (RAS) influences the skeletal system micro-structure and metabolism. Studies suggested angiotensin 1-7 (Ang(1-7)) as the beneficial RAS molecule via Mas receptor activation. This study examines the function of Ang(1-7) in bone micro-architecture and metabolism in an ovariectomized (OVX) rodent model of osteoporosis. OVX rats showed structural and bone metabolic degeneration in parallel with suppressed expressions of the angiotensin converting enzyme-2 (ACE-2)/Ang(1-7)/Mas components. The infusion of Ang(1-7) markedly alleviated the altered bone metabolism and significantly enhanced both trabecular (metaphyseal) and cortical (metaphyseal-diaphyseal) morphometry. Urinary and bones minerals were also improved in OVX rats by Ang(1-7). The infusion of the heptapeptide enhanced ACE-2/Mas receptor expressions, while down-regulated AngII, ACE, and AngII type-1 receptor (AT1R) in OVX animals. Moreover, Ang(1-7) markedly improved osteoprotegerin (OPG) and lowered receptor activator NF-κB ligand (RANKL) expressions. The defensive properties of Ang(1-7) on bone metabolism, structure and minerals were considerably eradicated after blockage of Mas receptor with A-779. Ang(1-7)-induced up-regulated ACE-2/Ang(1-7)/Mas cascade and OPG expressions were abolished and the expressions of ACE/AngII/AT1R and RANKL were provoked by A-779. These findings shows for the first time the novel valuable therapeutic role of Ang(1-7) on bone health and metabolism through the ACE-2/Mas cascade.

Analysis of epidemiological and clinical characteristics of patients admitted diagnosed with acute ischemic cerebrovascular event in internal medicine services and neurology of the Hospital Mexico in March 2013 to March 2014; Analisis de las caracteristicas epidemiologicas y clinicas de los pacientes ingresados con diagnostico de evento cerebrovascular isquemico agudo en los servicios de medicina interna y neurologia del Hospital Mexico de marzo 2013 a marzo 2014

Energy Technology Data Exchange (ETDEWEB)

Araya Gonzalez, Manuel Alberto

2014-07-01

mas frecuentemente encontradas han sido: hemiparesia faciobraquiocrural 60%, sindrome confusional 22%, disartria 22%, cefalea 20%, nauseas y/o vomito 17% y afasia en 15%. Un total de 13% de los pacientes han presentado alteracion de la consciencia y 5% ha necesitado soporte ventilatorio en las primeras 24 horas evolucion. El 27% de los pacientes han llegado en las primeras 3 horas de iniciado los sintomas, un 11% entre las 3 a 4.5 horas y el restante 62% mas alla de las 4.5 horas de evolucion. El 70% de los pacientes han tenido 1 o mas comorbilidades previas al evento, las 5 principales han sido: cardiopatia isquemica 31%, fibrilacion atrial 29%, enfermedad cerebrovascular 19%, enfermedad renal cronica 16% e insuficiencia cardiaca congestiva un 12%. En cuanto a la clasificacion topografica de los ictus, un 16% eran TACI, un 46% PACI, un 27% LACI y solo un 11% PoCI. El promedio de la escala de NIHSS ha sido de 9 puntos al ingreso, 10 a las 48 horas y 6 puntos al momento de egreso. Con respecto a la tomografia de cerebro al ingreso a 98% de los pacientes les fue realizada mientras que entre las 48 a 72 horas solo al 74%. Los hallazgos tomograficos mas frecuentes en el TAC inicial han sido: 49% hipodensidad de mas de 1/3 de territorio de arteria cerebral media, 46% sin alteraciones, 8% datos de edema cerebral y desviacion en la linea media. La transformacion hemorragica fue documentada en 6% de los casos. Al 70% de los pacientes les fue realizado ultrasonido Doppler de vasos del cuello. El 82% sin lesiones, un 9% con obstruccion entre 50-70% y 9% con mas de 70% obstruccion del lumen. La ecocardiografia fue realizada en 54% de los casos y fue obtenida 76% hipertrofia ventricular izquierda, 37% delitacion atrio izquierdo y 2% trombo intramural. Con respecto a la funcionalidad el 81% de los pacientes tenian ninguna o minima dependencia al momento de ingreso, para el momento de egreso 74% habian tenido discapacidad de moderada a severa, 12% leve y apenas un 14% se mostraba

Increasing the graduation rates of minority medical students.

Science.gov (United States)

Payne, J L; Nowacki, C M; Girotti, J A; Townsel, J; Plagge, J C; Beckham, T W

1986-05-01

The University of Illinois College of Medicine has operated a program since 1969 to recruit minority students into the college and to increase the graduation rates of these students once they enroll. Known as the Medical Opportunities Program (MOP) until 1978, the program was expanded in 1978 and renamed the Urban Health Program (UHP). The authors of the present paper discuss the results of these programs, particularly the effect of granting minority students delays in completing graduation requirements. The MOP (1969 through 1978) increased graduation rates for minority students from 55 percent for those who graduated on time to 81 percent for both on-time and delayed graduates. Under the first seven years of the UHP (1979 through 1985), more minority students have been offered places, and more have enrolled than in the 10 years of the MOP. The retention rate under the UHP, if it holds, will be higher than that under the MOP. For the combined MOP-UHP period, the retention rate for minority students was 88 percent; 69.8 percent of the graduates were on time, and 30.2 were delayed.

HR-MAS NMR for rapid identification of illicit substances in tablets and Blotter papers seized by Police Department

International Nuclear Information System (INIS)

Souza, Luciano F.; Vieira, Tarcísio S.; Lião, Luciano M.; Alcantara, Glaucia B.

2016-01-01

Illicit substances found in blotter papers and tablets seized by police are traditionally identified and characterized from extracts of these materials. However, the procedures involved in extraction stages can result in artifacts and even contamination of the samples to be analyzed. On the other hand, high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) is a technique that requires no pretreatment steps, enabling direct analysis of the material, including the analysis of new illegal synthetic psychoactive substances. This study presents and discusses applications of the HR-MAS NMR in the analysis of tablets and blotter papers seized. Additional analysis in solution of the extracts of these materials was performed to compare the obtained spectral resolution signals. The results demonstrated that the HR-MAS NMR allowed the rapid identification of 3,4-methylenedioxy-N-methylcathinone (methylone), 4-methylmethcathinone (mephedrone), 2,5-dimethoxy-4-bromoamphetamine (DOB) and 2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2- methoxyphenyl)methyl]ethanamine (25B-NBOMe) in samples of tablets and blotter papers seized in Goiás State, Brazil. (author)

HR-MAS NMR for rapid identification of illicit substances in tablets and Blotter papers seized by Police Department

Energy Technology Data Exchange (ETDEWEB)

Souza, Luciano F.; Vieira, Tarcísio S.; Lião, Luciano M., E-mail: lucianoliao@ufg.br [Universidade Federal de Goiás (UFG), Goiânia, GO (Brazil). Instituto de Química; Alcantara, Glaucia B. [Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, MS (Brazil). Instituto de Química

2016-07-01

Illicit substances found in blotter papers and tablets seized by police are traditionally identified and characterized from extracts of these materials. However, the procedures involved in extraction stages can result in artifacts and even contamination of the samples to be analyzed. On the other hand, high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) is a technique that requires no pretreatment steps, enabling direct analysis of the material, including the analysis of new illegal synthetic psychoactive substances. This study presents and discusses applications of the HR-MAS NMR in the analysis of tablets and blotter papers seized. Additional analysis in solution of the extracts of these materials was performed to compare the obtained spectral resolution signals. The results demonstrated that the HR-MAS NMR allowed the rapid identification of 3,4-methylenedioxy-N-methylcathinone (methylone), 4-methylmethcathinone (mephedrone), 2,5-dimethoxy-4-bromoamphetamine (DOB) and 2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2- methoxyphenyl)methyl]ethanamine (25B-NBOMe) in samples of tablets and blotter papers seized in Goiás State, Brazil. (author)

SATISFACCIÓN CON EL TRATAMIENTO EN PACIENTES DE ATENCIÓN PRIMARIA CON ARTROSIS

Directory of Open Access Journals (Sweden)

Carmen Llanos Val Jiménez

2017-01-01

Full Text Available Fundamentos: Al igual que en otros problemas crónicos, en el abor - daje del paciente con artrosis se tiende a un modelo de toma de decisiones compartidas, en el que el punto de vista del paciente debe ser considerado en la elección del tratamiento. El objetivo de este trabajo fue evaluar la sa - tisfacción con el tratamiento en pacientes diagnosticados de osteoartrosis y comprobar si existen diferencias entre diferentes opciones farmacológicas, así como determinar si existe asociación con el estado funcional y las carac - terísticas clínicas y sociodemográficas. Métodos: Se realizó un estudio observacional transversal en una muestra de 487 pacientes seleccionados mediante muestreo consecutivo. La variable principal fue el nivel de satisfacción con el tratamiento (cuestionario ARTS. El estado funcional de los pacientes fue evaluado mediante la escala WO - MAC. Otras variables fueron: características del tratamiento, adherencia te - rapéutica, eventos adversos, y variables clínicas y sociodemográficas. Resultados: En el cuestionario ARTS los pacientes, en un rango entre 28 y 87, obtuvieron una puntuación media de 65,3 (DE: 9,9. La puntuación no fue significativamente diferente en consumidores de 1, 2 o más fármacos. Entre quienes consumían un solo fármaco, no hubo diferencias entre los di - ferentes tipos de fármacos. En el estado funcional se obtuvo una puntuación media de 30,2 puntos (DE: 20,8 y se observó una débil correlación negativa con el nivel de satisfacción (r= - 0,252; p<0,001. Mediante regresión lineal múltiple, se observó mayor puntuación en la escala ARTS (p<0,05 en pa - cientes con menor puntuación en la escala WOMAC, mayor edad y ausencia de eventos adversos. Conclusión : En pacientes con osteoartritis se observa un nivel mode - rado de satisfacción con el tratamiento farmacológico, condicionado por su situación funcional, sus características sociodemográficas y por la presencia de eventos

Characterizing crystal disorder of trospium chloride: a comprehensive,(13) C CP/MAS NMR, DSC, FTIR, and XRPD study.

Science.gov (United States)

Urbanova, Martina; Sturcova, Adriana; Brus, Jiri; Benes, Hynek; Skorepova, Eliska; Kratochvil, Bohumil; Cejka, Jan; Sedenkova, Ivana; Kobera, Libor; Policianova, Olivia; Sturc, Antonin

2013-04-01

Analysis of C cross-polarization magic angle spinning (CP/MAS) nuclear magnetic resonance (NMR), differential scanning calorimetry (DSC), Fourier transform infrared (FTIR), and X-ray powder diffraction data of trospium chloride (TCl) products crystallized from different mixtures of water-ethanol [φ(EtOH) = 0.5-1.0] at various temperatures (0°C, 20°C) and initial concentrations (saturated solution, 30%-50% excess of solvent) revealed extensive structural variability of TCl. Although (13) C CP/MAS NMR spectra indicated broad variety of structural phases arising from molecular disorder, temperature-modulated DSC identified presence of two distinct components in the products. FTIR spectra revealed alterations in the hydrogen bonding network (ionic hydrogen bond formation), whereas the X-ray diffraction reflected unchanged unit cell parameters. These results were explained by a two-component character of TCl products in which a dominant polymorphic form is accompanied by partly separated nanocrystalline domains of a secondary phase that does not provide clear Bragg reflections. These phases slightly differ in the degree of molecular disorder, in the quality of crystal lattice and hydrogen bonding network. It is also demonstrated that, for the quality control of such complex products, (13) C CP/MAS NMR spectroscopy combined with factor analysis (FA) can satisfactorily be used for categorizing the individual samples: FA of (13) C CP/MAS NMR spectra found clear relationships between the extent of molecular disorder and crystallization conditions. © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 102:1235-1248, 2013. Copyright © 2013 Wiley Periodicals, Inc.

SATISFACCIÓN DE LAS PERSONAS CON LESIÓN MEDULAR CON EL SERVICIO DE PROMOCIÓN DE LA AUTONOMÍA PERSONAL EN LAS ISLAS BALEARES

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Miguel Ángel Capó-Juan

2016-01-01

Full Text Available Fundamentos: El Servicio de Promoción de la Autonomía Personal pretende ofrecer atención a sujetos con discapacidad física y/o físico-psíquica grave, entre ellos, a personas con lesión medular. Estas personas se encuentran en una fase crónica y por ello requieren medidas fisioterápicas educativo–terapéuticas. El objetivo de este estudio fue determinar la satisfacción de las personas con lesión medular que acuden a este servicio. Métodos: Se llevó a cabo un estudio descriptivo, transversal, cuantitativo después de un seguimiento terapéutico de dieciséis meses que se inició en marzo de 2015. La muestra final del estudio fue de 25 personas con lesión medular (17 hombres y 8 mujeres que supusieron el 83% del total de las atendidas. Al finalizar la intervención terapéutica, estas personas respondieron al cuestionario SERVQHOS que consta de diecinueve preguntas y pretende medir la calidad asistencial de los servicios prestados. Se llevó a cabo un análisis estadístico a través Microsoft Office Excel 2013 y SPSS 23, calculando medias y desviaciones estándar o frecuencias y porcentajes. Resultados: El factor externo mejor valorado fue la apariencia del personal con un 4,5 de media y el peor valorado la accesibilidad y/o señalización con un 2,6 de media. El factor interno mejor valorado fue la amabilidad del personal con un 4,8 de media y el peor valorado la rapidez con la que se consigue lo que se solicita, con un 4,2 de media. Conclusiones: Tras el estudio se concluye que la calidad ofrecida está determinada por los factores internos (amabilidad, confianza y disposición de ayudar y que las debilidades vienen relacionadas con factores externos estructurales del centro.

Pharmacological significance of the interplay between angiotensin receptors: MAS receptors as putative final mediators of the effects elicited by angiotensin AT1 receptors antagonists.

Science.gov (United States)

Pernomian, Larissa; Pernomian, Laena; Gomes, Mayara S; da Silva, Carlos H T P

2015-12-15

The interplay between angiotensin AT1 receptors and MAS receptors relies on several inward regulatory mechanisms from renin-angiotensin system (RAS) including the functional crosstalk between angiotensin II and angiotensin-(1-7), the competitive AT1 antagonism exhibited by angiotensin-(1-7), the antagonist feature assigned to AT1/MAS heterodimerization on AT1 signaling and the AT1-mediated downregulation of angiotensin-converting enzyme 2 (ACE2). Recently, such interplay has acquired an important significance to RAS Pharmacology since a few studies have supporting strong evidences that MAS receptors mediate the effects elicited by AT1 antagonists. The present Perspective provides an overview of the regulatory mechanisms involving AT1 and MAS receptors, their significance to RAS Pharmacology and the future directions on the interplay between angiotensin receptors. Copyright © 2015 Elsevier B.V. All rights reserved.

Development of teleoperated cleanup system

International Nuclear Information System (INIS)

Kim, Ki Ho; Park, J. J.; Yang, M. S.; Kwon, H. J.

2005-01-01

This report describes the development of a teleoperated cleanup system for use in a highly radioactive environment of DFDF(DUPIC Fuel Demonstration Facility) at KAERI where direct human access to the in-cell is strictly limited. The teleoperated cleanup system was designed to remotely remove contaminants placed or fixed on the floor surface of the hot-cell by mopping them with wet cloth. This cleanup system consists of a mopping slave, a mopping master and a control console. The mopping slave located at the in-cell comprises a mopping tool with a mopping cloth and a mobile platform, which were constructed in modules to facilitate maintenance. The mopping master that is an input device to control the mopping slave has kinematic dissimilarity with the mopping slave. The control console provides a means of bilateral control flows and communications between the mopping master and the mopping slave. In operation, the human operator from the out-of-cell performs a series of decontamination tasks remotely by manipulating the mopping slave located in-cell via a mopping master, having a sense of real mopping. The environmental and mechanical design considerations, and control systems of the developed teleoperated cleanup system are also described

L’immigrazione islamica ed i conflitti con l’ordinamento giuridico spagnolo

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Jose Antonio Rodriguez Garcia

2011-10-01

Full Text Available SOMMARIO: 1. Premessa: il sistema spagnolo di relazioni tra Stato e confessioni religiose - 1.1. La libertà di coscienza - 2. Uguaglianza nella libertà - 3. Laicità - 4. La cooperazione dello Stato con le confessioni religiose- 5. Gli accordi con la Chiesa cattolica - 6. Gli accordi con le minoranze religiose - 7. L’immigrazione islamica ed i conflitti con l’ordinamento giuridico spagnolo - 8. Educazione e immigrati islamici - 9. Diritto di famiglia e gli immigrati islamici - 10. Altri conflitti: libertà religiosa e l’immigrazione islamica - 11. Proposta di soluzioni.

Atención odontológica a un bebé con holoprosencefalía: relato de caso clínico

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Márcia Cançado Figueiredo

Full Text Available Ejercer el rol de cuidador de un niño con deformaciones congénitas es una tarea difícil y representa un componente importante dentro de la familia en tanto que esa persona se hace responsable del cuidado de ese ser especial. Para que esto suceda, la conducta de los profesionales del área de la salud frente a este contexto debe ser específica y de calidad, de modo a ofrecer el soporte necesario a la familia/cuidador. Con el fin de promover una atención efectiva, los profesionales deben buscar el conocimiento del síndrome que afecta al paciente, así como su respuesta conductual y sus características mas prevalentes. El presente trabajo tuvo como objetivo presentar el informe de un caso clínico de un paciente bebé del sexo femenino, que requiere de cuidados exclusivos por parte de sus padres, quienes buscaron asistencia en la Universidad Federal de Río Grande do Sul, Brasil, en la disciplina Atención Odontológica al Paciente Necesidades Especiales. También se hace hincapié en el manejo y los cuidados por parte del odontólogo de aquellos pacientes con discapacidad desde el momento de su nacimiento, a fin de proporcionarles los recursos adecuados a través de orientaciones en cuanto a la higiene bucal con el fin de que se pueda instalar y mantener las condiciones de la salud oral, mejorando la calidad de vida de los pacientes con discapacidad

Determination of the structural changes by Raman and {sup 13}C CP/MAS NMR spectroscopy on native corn starch with plasticizers

Energy Technology Data Exchange (ETDEWEB)

Cozar, O. [Academy of Romanian Scientists, Splaiul Independentei 54, 050094, Bucharest, Romania and National Institute of Research-Development for Machines and Installations Designed to Agriculture and Food Industry - INMA Bucureşti - Cluj-Napoca Branch (Romania); Filip, C.; Tripon, C. [National Institute for Research and Development of Isotopic and Molecular Technologies, 65-103 Donath, 400293 Cluj-Napoca (Romania); Cioica, N.; Coţa, C.; Nagy, E. M. [National Institute of Research-Development for Machines and Installations Designed to Agriculture and Food Industry - INMA Bucureşti - Cluj-Napoca Branch, RO-400458 Cluj-Napoca (Romania)

2013-11-13

The plasticizing - antiplasticizing effect of water and glycerol contents on native corn starch samples is investigated by FT-Raman and {sup 13}C CP/MAS NMR spectroscopy. The presence of both amorphous and crystalline structural phases was evidenced in pure native corn starch and also in the samples containing plasticizers. Among the crystalline starch structures, the A- and V- types were suggested by CP/MAS NMR spectra.

Infliximab en pacientes con enfermedad ocular inflamatoria, refractarios a DARMES

Directory of Open Access Journals (Sweden)

Elmer R. García-Salazar

2013-07-01

Full Text Available Se describe la experiencia con infliximab (anticuerpo monoclonal con una potente acción antiinflamatoria en el tratamiento de enfermedades oculares inflamatorias secundarias a patologías reumáticas y refractarias a drogas antirreumáticas modificadoras de la enfermedad (DARMES. Se evaluó el caso de una paciente de 50 años con artritis reumatoide (AR de fondo activo y una paciente de 37 años con vasculitis anticuerpos anticitoplasma de neutrófilos especifico para mieloperoxidasa (ANCA MPO sin compromiso de órgano noble, ambas con escleritis bilateral y perforación con prolapso de iris del ojo izquierdo. Ellas recibieron infliximab EV en dosis de 3 a 5 mg/kg/dosis, según el esquema, a las 0, 2, 6 y 8 semanas. Infliximab resultó eficaz y seguro para el tratamiento de escleritis asociada a AR y vasculitis ANCA MPO positivo, refractaria a tratamiento con DARMES y corticoides en dosis altas. Los injertos de tejido esclerocorneal evolucionaron favorablemente con infliximab.

Factores influyentes en adherencia al tratamiento en pacientes con riesgo cardiovascular

Directory of Open Access Journals (Sweden)

Alba Luz Rodríguez Acelas

2010-06-01

Full Text Available Objetivo: describir y analizar los factores que influyen en la adherencia al tratamiento farmacológico y no farmacológico en pacientes con riesgo de enfermedad cardiovascular en la Fundación Cardiovascular de Colombia. Metodología: estudio descriptivo-metodológico, realizado con 172 pacientes hospitalizados y de consulta ambulatoria. El instrumento aplicado fue diseñado por Bonilla (8, su utilidad es evaluar la adherencia a los tratamientos farmacológicos y no farmacológicos en pacientes con factores de riesgo de enfermedad cardiovascular, tiene pruebas de validez facial y contenido (0,91, consistencia interna por test-retest estadísticamente significativo y coeficiente alfa de Cronbach (0,85; este último hallado en el presente estudio. Resultados: 80,8% de las personas presentan alto riesgo de no adherirse, 12,8% con ventajas y 6,4% no muestra adherencia a los tratamientos. Las edades oscilaron entre 23-85, la asistencia a la institución en mujeres fue 63,4% respecto a hombres (36,6%. Asimismo, se evidenció que la adherencia beneficia el factor relacionado con el paciente. En contraste, disminuyen los factores relacionados con el proveedor: sistema y equipo de salud, con la terapia y el factor socioeconómico. Discusión y conclusiones: entre los factores que apoyan la adherencia se encuentra el reconocimiento de la enfermedad, confianza en el tratamiento, apoyo de redes sociales y respaldo de la institución. A diferencia, debilitan la adherencia las dificultades económicas, falta de permisos, dificultades en modificar hábitos y déficit de conocimientos. Los resultados reflejan la necesidad de fortalecer a los profesionales de la salud en el manejo de la adherencia desde los ámbitos académicos y la creación o fortalecimiento de los programas educativos en las instituciones de salud.

Tecnicas de etiquetado de senales opticas en redes de conmutacion de rafagas

NARCIS (Netherlands)

Vegas Olmos, J.J.; Tafur Monroy, I.; Koonen, A.M.J.

2003-01-01

En este artículo presentamos una revision de los asuntos mas importantes relacionados con las redes de conmutacion de ráfagas de señales ópticas etiquetadas (LOBS – Labeled optical burst switched) y las En este artículo presentamos una revision de los asuntos mas importantes relacionados con las

The ACE-2/Ang1-7/Mas cascade enhances bone structure and metabolism following angiotensin-II type 1 receptor blockade.

Science.gov (United States)

Abuohashish, Hatem M; Ahmed, Mohammed M; Sabry, Dina; Khattab, Mahmoud M; Al-Rejaie, Salim S

2017-07-15

The renin angiotensin system (RAS) regulates numerous systemic functions and is expressed locally in skeletal tissues. Angiotensin1-7 (Ang1-7) is a beneficial member of the RAS, and the therapeutic effects of a large number of angiotensin receptors blockers (ARBs) are mediated by an Ang1-7-dependent cascade. This study examines whether the reported osteo-preservative effects of losartan are mediated through the angiotensin converting enzyme2 (ACE-2)/Ang1-7/Mas pathway in ovariectomized (OVX) rats. Sham and OVX animals received losartan (10mg/kg/d p.o.) for 6 weeks. A specific Mas receptor blocker (A-779) was delivered via mini-osmotic pumps during the losartan treatment period. Serum and urine bone metabolism biomarker levels were measured. Bone trabecular and cortical morphometry were quantified in distal femurs, whereas mineral contents were estimated in ashed bones, serum and urine. Finally, the expression of RAS components, the receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG) was determined. Losartan significantly improved the elevated bone metabolism marker levels and altered trabecular and cortical structures in OVX animals, and restored normal urinary and skeletal mineral levels. Mas receptor inhibition significantly abolished all osteo-protective effects of losartan and enhanced the deleterious effects of OVX. Losartan enhanced OVX-induced up-regulation of ACE-1, AngII, angiotensin type 1 (AT 1 ) receptor and RANKL expression, and increased ACE-2, Ang1-7, Mas and OPG expression in OVX animals. However, A-779 significantly eradicated the effects of losartan on RAS components and RANKL/OPG expression. Thus, Ang1-7 are involved in the osteo-preservative effects of losartan via Mas receptor, which may add therapeutic value to this well-known antihypertensive agent. Copyright © 2017 Elsevier B.V. All rights reserved.

"McDonald's" reklāmas analīze Latvijā un Maltā - starpkultūru atšķirīgā uztvere

OpenAIRE

Barkēviča, Santa

2016-01-01

Darbā ““McDonald's” reklāmas analīze Latvijā un Maltā – starpkultūru atšķirīgā uztvere” galvenais problēmjautājums, kas jānoskaidro, vai starptautisks uzņēmums var izmantot viena stila reklāmas kampaņu divās dažādās valstīs – Latvijā un Maltā. Galvenais darba mērķis ir noskaidrot, vai starptautisks uzņēmums var veidot vienu reklāmas kampaņu shēmu, un to izmantot dažādās valstīs, kur atrodas tā franšīzes vai filiāles, un kā starpkultūru atšķirība ietekmē reklāmas uztveri. Veicot aptaujas, inte...

“Estado Nación laico y secularización masónica en México”

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Carlos Francisco Martínez Moreno

2011-01-01

Full Text Available Este artículo busca mostrar cómo y porqué los masones practicantes del Rito Nacional Mexicano en el siglo XIX secularizaron su tradición para responder a sus compromisos sociales, patrióticos, liberales y democráticos. Además, muestra cómo ellos sustituyeron La Biblia por la Constitución Política de los Estados Unidos Mexicanos en sus juramentos masónicos, en un contexto social en el que jurarla se consideraba un anatema por el Papa Pío IX y el clero católico, y en un contexto masónico adverso en el que sustituir el Libro de la Ley y participar en la política como masones era contravenir la tradición especulativa londinense.

Adult height in Turner syndrome girls after long-term growth hormone treatment Talla adulta en pacientes con síndrome de Turner tratadas con hormona de crecimiento a largo plazo

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Analía Morín

2009-10-01

Full Text Available We studied the adult height (AH outcome, and factors likely to influence it, in Turner Syndrome (TS girls treated with growth hormone (GH. A total of 25 TS girls treated with GH were compared with 10 TS girls not treated with GH. The percentage of girls who achieved normal third percentile was determined. Projected AH (PAH was calculated according to height standard deviation score (HSDS at the beginning of the treatment. Gain in height was determined as: AH - pretreatment PAH. The percentage of girls who achieved target range (midparental height±2 SD was determined. Multiple linear regression models were fitted on baseline variables- chronological age (CA, midparental height (MPH and HSDS; and treatment variablesduration of oestrogen-free GH therapy and duration of GH therapy+oestrogens. As for baseline data: median CA was 13.0 years (5.6-15.8. Mean HSDS was 0.25±1.1 SDS. PAH was 139.2±5.6 cm. MPH was 160.0±5.0 cm. As for follow up data: Median CA at onset oestrogens was 15.1 years (13.2-16.6. Median duration of GH therapy was 3.8 years (2.1-10.3. Median oestrogen-free GH period was 2.0 years (0.7-7.8, and median GH+oestrogens period, 1.8 years (1.0-3.2. Adult height: Mean AH was 150.4±7.0 cm in treated patients and 140.8±7.2 cm in the group not treated with GH (p=0.001. Fourteen (56% girls achieved normal third percentile compared with an initially predicted 1 (4%. Gain in height was 11.2±3.7 cm. Thirteen (59% girls reached an AH within target range. HSDS at the beginning of the treatment was the variable most strongly related to AH and duration of oestrogen-free GH period was the variable most strongly related to gain in height.Se estudió la talla adulta (TA y los factores que pudieran influenciarla en niñas con síndrome de Turner (ST tratadas con hormona de crecimiento (HC. Se compararon 25 pacientes con ST tratadas con HC y 10 niñas no tratadas. Se determinó: el porcentaje de niñas que alcanzó el tercer percentilo de la curva

Investigation of molecular mechanisms in photodynamic action and radiobiology with nanosecond flash photolysis and pulse radiolysis. Progress report, July 1, 1975--June 30, 1976

International Nuclear Information System (INIS)

Grossweiner, L.I.

1976-03-01

Flash photolysis studies have shown that exposed tyrosyl or tryptophyl residues of enzymes are photoionized at approximately the same quantum efficiency as the aqueous amino acids. Comparisons with permanent damage indicate that this primary process contributes to inactivation when a photolyzed aromatic residue is essential or is located adjacent to a catalytic, non-chromoporic residue. Studies on sensitization by the phototherapeutic drug, 8-methoxypsoralen (8-MOP), show the triplet state can lead to singlet oxygen generation and that weak binding to poly (dA-dT) suppresses this process. 8-MOP was found to be potent sensitizer of yeast photoinactivation with negligible post-irradiation recovery. Spinlable ESR measurements made on yeast cells after photodynamic treatment show that the membrane damage generated by the penetrating dye Toluidine Blue 0 is more extensive than the external dye, Eosin Y. In related ionizing radiation studies, it was found that 8-MOP is an anoxic radiosensitizer of T7 phage, attributed to enhancement of crosslinks; that complexing of eosin to lysozyme sensitizes the enzyme to oxidizing radicals; that the reactions of Br 2 - and (CNS) 2 - with tryptophan generate the same initial radical as uv-excited photoionization

Ansiedad, depresión y percepción de control en mujeres diagnosticadas con VIH/Sida

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Marcela Arrivillaga Quintero

2006-01-01

Full Text Available En la actualidad mundial se observa un aumento significativo de casos de infección por VIH en mujeres. Las nuevas medicaciones antirretrovirales han logrado avances en cuanto a la cantidad de vida mas no a su calidad ya que variables psicológicas afectan la evoluci ón de la infección. Esta investigación describe la ansiedad, depresión y percepción de control como variables psicológicas que intervienen en el proceso de infección. Dentro de los hallazgos más importantes se encuentra que un considerable número de participantes (23,4% presentó altos niveles de ansiedad. Algunos (10,63% presentaron altos niveles de depresión y en un menor número (6,38% se encontró bajos niveles de Percepci ón de Control. Los resultados de esta última variable están relacionados con conclusiones de otras investigaciones donde se plantea su importancia en factores como: generación de conductas de autocuidado, sensación de autoeficacia, entre otros. Finalmente, se confirmó que la percepción de control es un predictor de salud mental y física. Esta investigación fue de carácter no experimental, de tipo descriptivo-correlacional con diseño transversal y en ella participaron 48 mujeres diagnosticadas con VIH/Sida de la ciudad de Cali, Colombia

Quality of Milk Pasteurized Produced By UD. Gading Mas During Storage in Refrigerator

Directory of Open Access Journals (Sweden)

Manik Eirry Sawitri

2012-02-01

Full Text Available The aim of this research was to study pasteurized milk quality produced by UD. Gading Mas on pH, Acidity, alcohol test and TPC during 5 days storage in refrigerator. On first day showed that  weight mass 1,06 (w/w; fat content 2,00 (g/100g,  protein content 3,02  (g/100g, Zn 1,67 ppm, Cu<0,005 ppm, Pb 0,02 ppm,  As  0,0120 ppm, Hg< 0,0002 ppm, Sn 1,60 ppm dan Cd < 0,001 ppm and organoleptic test included color, flavor and taste were normal. Pasteurized milk characteristic during 5 days refrigeration for pH were 6,57;6,58;6,73;6,60 and 6,50 respectively. Acidity were 1,147 %, 0,145 %, 0,145%, 0,157 %, 0,156 % and 0,175  % respectively. TPC were 6,16 x 101, 1,2. 104; 3,15.104, 0,42.106 and 3,5.108 respectively. It concluded that pasteurized milk produced by UD Gading Mas fulfilled SNI quality standard based on weight mass, pH, acidity, fat, protein, heavy metal content, organoleptic test and TPC.   Keywords: pasteurized milk, quality, refrigerator

Enfermedad coronaria en pacientes con psoriasis

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Walter Masson

2013-10-01

Full Text Available Comunicaciones previas asociaron la psoriasis con la enfermedad coronaria. Desconocemos si en nuestro país o región existe dicha asociación. Se realizó un estudio transversal analizando los datos de la historia clínica electrónica de un sistema de salud de Buenos Aires. Analizamos todos los pacientes mayores de 18 años con diagnóstico de psoriasis entre el 1 de enero de 2003 y el 31 de julio de 2011 y los comparamos con un grupo control, en una relación 2:1, obtenido en forma aleatoria del mismo sistema de salud, apareados por edad y sexo. Determinamos la prevalencia de los factores de riesgo cardiovascular y de enfermedad coronaria. Analizamos la asociación entre la enfermedad coronaria y la psoriasis mediante análisis uni y multivariado. Se incluyeron 3 833 sujetos (1 286 pacientes con psoriasis y 2 547 controles. La prevalencia de hipertensión arterial (50% vs. 38%, p < 0.001, tabaquismo (25% vs. 17%, p < 0.001, diabetes (12% vs. 8%, p < 0.001 y enfermedad coronaria (4.98% vs. 3.06%, p = 0.003 fue mayor en los sujetos con psoriasis en comparación con el grupo control. Independientemente de la edad, la presencia de diabetes, hipertensión arterial o tabaquismo, hubo una asociación significativa entre la enfermedad coronaria y la psoriasis (OR 1.48, IC95% 1.04-2.11, p = 0.03. En conclusión, en esta población de Buenos Aires, los pacientes con psoriasis tuvieron una mayor prevalencia de diabetes, hipertensión arterial, tabaquismo y enfermedad coronaria. La asociación entre la psoriasis y la enfermedad coronaria fue independiente de los factores de riesgo explorados.

Role of Mas receptor in renal blood flow response to angiotensin (1-7) in male and female rats.

Science.gov (United States)

Nematbakhsh, Mehdi; Safari, Tahereh

2014-01-01

Epidemiologic and clinical studies have shown that progression of renal disease in male is faster than that in female. However, the exact mechanisms are not well recognized. Angiotensin (1-7) (Ang 1-7) receptor, called "Mas", is an element in the depressor arm of renin angiotensin system (RAS), and its expression is enhanced in females. We test the hypothesis that Mas receptor (MasR) blockade (A779) attenuates renal blood flow (RBF) in response to infusion of graded doses of Ang 1-7 in female rats. Male and female Wistar rats were anesthetized and catheterized. Then, the mean arterial pressure (MAP), RBF, and controlled renal perfusion pressure (RPP) responses to infusion of graded doses of Ang 1-7 (100-1000 ng/kg/min i.v.) with and without A779 were measured in the animals. Basal MAP, RPP, RBF, and renal vascular resistance (RVR) were not significantly different between the two groups. After Ang 1-7 administration, RPP was controlled at a constant level. However, RBF increased in a dose-related manner in response to Ang 1-7 infusion in both male and female rats (Pdoserenal diseases.

Relation Between Acid and Catalytic Properties of Chlorinated Gamma-Alumina. a 31p Mas Nmr and Ftir Investigation

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Guillaume D.

1999-07-01

Full Text Available In this paper, we have studied the effect of chlorine on the surface properties of gamma-alumina, especially on their acid properties. The use of FTIR spectroscopy and 31P MAS NMR of adsorbed trimethylphosphine allows to propose a chlorination mechanism. To correlate the surface properties of these chlorinated gamma-alumina with their catalytic properties, we have used a model reaction, the cracking of n-heptane under reforming conditions. The analysis of the correlation between acid properties determined by 31P MAS NMR and the catalytic results (in terms of activities and selectivities allows to identify which sites are involved in the cracking reaction.

Decision-making support system based on MAS for emergency response to nuclear accidents of marine pressurized-water reactor

International Nuclear Information System (INIS)

Chen Dengke; Zhang Dafa; Jiang Wei; Chen Yonghong

2007-01-01

Emergency decision-making to Marine Pressurized-Water Reactor (MPWR) was severely restricted by the complex environment. To enhance the emergency decision-making ability of MPWR, reducing the effect of emergencies, an emergency Decision-making Support System (DSS) which based on Multi-agent System (MAS) was presented. In the system, the HLA/RTI was used as the support environment, and the structure and the Control Agent (SCA), Analyse Agent (AA), Countermeasure Agent (CA), Evaluation Agent (EVA) and Environment Agent (ENA) were designed. The MAS were with the characteristics of autonomy, reactivity and initiative, which were fully used in the system to make effective decision for emergencies. (authors)

MODIS Airborne Simulator (MAS) Measurements Taken Onboard the NASAER-2 During the TOGA COARE Intensive Observing Period

Data.gov (United States)

National Aeronautics and Space Administration — The TOGA COARE Data Information System has responsibility for distributing information about TOGA COAREdatasets and access paths.The MAS data are available upon...

MAS: Malware Analysis System Based on Hardware-Assisted Virtualization Technology

Science.gov (United States)

Kim, Taehyoung; Kim, Inhyuk; Min, Changwoo; Eom, Young Ik

There are many analysis techniques in order to analyze malicious codes. However, recently malicious codes often evade detection using stealthy obfuscation techniques, and attack computing systems. We propose an enhanced dynamic binary instrumentation using hardware-assisted virtualization technology. As a machine-level analyzer, our system can be isolated from almost the whole threats of malware, and provides single step analysis environment. Proposed system also supports rapid system call analysis environment. We implement our malware analysis system (referred as MAS) on the KVM hypervisor with Intel VT-x virtualization support. Our experiments with benchmarks show that the proposed system provides efficient analysis environment with low overhead.

Defectos del dorso nasal tratados con injerto autólogo

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Ángel Soto Fernández

2005-08-01

Full Text Available Se operaron 10 pacientes con defectos del dorso nasal, 9 catalogados de grandes (4 mm o más y uno con menos de 1 mm. En la mayoría predominó el sexo masculino y el defecto fue adquirido. En 9 de los pacientes con defectos grandes se utilizó injerto de hueso de cresta ilíaca en forma de L descansando en huesos propios y espina nasal, y en uno con defecto pequeño se utilizó cartílago. El resultado es evaluado después de 8 años como satisfactorio estética y funcionalmente, sin evidencia clínica de reabsorción.

Actividad anticaries de una crema dental con propóleos

OpenAIRE

Estela Gispert Abreu; Elena Cantillo Estrada; Aracelys Rivero López; Marela Padrón Illance

2000-01-01

Por muestreo aleatorio simple se seleccionaron 50 escolares con antecedentes de alta infección por Streptococcus mutans, para verificar la actividad anticaries de una crema dental que contiene 0,8 de extracto de propóleo blando. Se perdieron del estudio a 7 escolares por inasistencia y traslados. Se crearon 2 grupos: uno control (n=19) que se cepilló con una crema dental placebo y otro tratamiento (n=24) que se cepilló con la crema dental de propóleo. Entre ambos grupos no había diferencia si...

8 Meter Advanced Technology Large-Aperture Space Telescope (ATLAST-8m)

Science.gov (United States)

Stahl, H. Philip

2010-01-01

ATLAST-8m (Advanced Technology Large Aperture Space Telescope) is a proposed 8-meter monolithic UV/optical/NIR space observatory (wavelength range 110 to 2500 nm) to be placed in orbit at Sun-Earth L2 by NASA's planned Ares V heavy lift vehicle. Given its very high angular resolution (15 mas @ 500 nm), sensitivity and performance stability, ATLAST-8m is capable of achieving breakthroughs in a broad range of astrophysics including: Is there life elsewhere in the Galaxy? An 8-meter UVOIR observatory has the performance required to detect habitability (H2O, atmospheric column density) and biosignatures (O2, O3, CH4) in terrestrial exoplanet atmospheres, to reveal the underlying physics that drives star formation, and to trace the complex interactions between dark matter, galaxies, and intergalactic medium. The ATLAST Astrophysics Strategic Mission Concept Study developed a detailed point design for an 8-m monolithic observatory including optical design; structural design/analysis including primary mirror support structure, sun shade and secondary mirror support structure; thermal analysis; spacecraft including structure, propulsion, GN&C, avionics, power systems and reaction wheels; mass and power budgets; and system cost. The results of which were submitted by invitation to NRC's 2010 Astronomy & Astrophysics Decadal Survey.

Valsartan attenuates intimal hyperplasia in balloon-injured rat aortic arteries through modulating the angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas receptor axis.

Science.gov (United States)

Li, Yonghong; Cai, Shanglang; Wang, Qixin; Zhou, Jingwei; Hou, Bo; Yu, Haichu; Ge, Zhiming; Guan, Renyan; Liu, Xu

2016-05-15

The role of the Mas receptor in the activity of valsartan against intimal hyperplasia is unclear. Herein, we investigated the role of the angiotensin-converting enzyme 2 (ACE2)-angiotensin-(1-7)-Mas receptor axis on the activity of valsartan against intimal hyperplasiain balloon-injured rat aortic arteries. Wistar rats were randomized equally into the sham control group, injured group, and injured plus valsartan (20 mg/kg/d)-treated group. Valsartan significantly attenuated the vascular smooth muscle cell proliferation and intimal and medial thickening on days 14 and 28 after injury. The angiotensin-(1-7) levels as well as ACE2 and Mas receptor mRNA/protein expression were significantly decreased in the injured rats, compared to the uninjured rats; meanwhile, the angiotensin II level as well as the ACE and AT1 receptor mRNA/protein expression were increased (all P valsartan significantly increased the angiotensin-(1-7) levels as well as ACE2 and Mas receptor mRNA/protein expression but decreased the angiotensin II level, ACE and AT1 receptor mRNA/protein expression, as well as the p-ERK protein expression, compared to the injured group (all P valsartan attenuates neointimal hyperplasiain balloon-injured rat aortic arteries through activation of the ACE2-angiotensin-(1-7)-Mas axis as well as inhibition of the ACE-angiotensin II-AT1 and p-ERK pathways. Copyright © 2016 Elsevier Inc. All rights reserved.

Reorientation of the Methyl Group in MAs(III) is the Rate-Limiting Step in the ArsM As(III) S-Adenosylmethionine Methyltransferase Reaction.

Science.gov (United States)

Packianathan, Charles; Li, Jiaojiao; Kandavelu, Palani; Sankaran, Banumathi; Rosen, Barry P

2018-03-01

The most common biotransformation of trivalent inorganic arsenic (As(III)) is methylation to mono-, di-, and trimethylated species. Methylation is catalyzed by As(III) S -adenosylmethionine (SAM) methyltransferase (termed ArsM in microbes and AS3MT in animals). Methylarsenite (MAs(III)) is both the product of the first methylation step and the substrate of the second methylation step. When the rate of the overall methylation reaction was determined with As(III) as the substrate, the first methylation step was rapid, whereas the second methylation step was slow. In contrast, when MAs(III) was used as the substrate, the rate of methylation was as fast as the first methylation step when As(III) was used as the substrate. These results indicate that there is a slow conformational change between the first and second methylation steps. The structure of CmArsM from the thermophilic alga Cyanidioschyzon merolae sp. 5508 was determined with bound MAs(III) at 2.27 Å resolution. The methyl group is facing the solvent, as would be expected when MAs(III) is bound as the substrate rather than facing the SAM-binding site, as would be expected for MAs(III) as a product. We propose that the rate-limiting step in arsenic methylation is slow reorientation of the methyl group from the SAM-binding site to the solvent, which is linked to the conformation of the side chain of a conserved residue Tyr70.

Considerations for Consortia as States Transition Away from AA-MAS. NCEO Brief. Number 7

Science.gov (United States)

National Center on Educational Outcomes, 2014

2014-01-01

States with an alternate assessment based on modified achievement standards (AA-MAS) that received a flexibility waiver from some of the requirements of No Child Left Behind are required to phase out their use of this assessment. And, on August 23, 2013, the U.S. Department of Education published a proposed rollback of regulation that allowed the…

Experimental proposal for the anticipated feasible detection of earthquakes; Propuesta experimental para la deteccion factible de terremotos con anticipacion

Energy Technology Data Exchange (ETDEWEB)

Lopez Ortega, Sergio [Instituto Politecnico Nacional, Mexico D.F. (Mexico)

2004-07-15

magnitud peligrosa. En otras partes del mundo se estan efectuando algunas investigaciones con estas OEM a un alto nivel tecnologico pero sin relacion con las plantas, mas bien, enfocadas a su efecto en animales e insectos, o en la ionizacion del aire y el agua. El experimento aqui expuesto, por su misma simpleza permite suponer que no ha sido efectuado en otros paises, no existen referencias bibliograficas ni de Internet al respecto y desde este punto de vista representa una alternativa para lograr predicciones sismicas, por lo que potencialmente puede tener mucha trascendencia, asi, el objetivo principal de su divulgacion es tambien tratar de darle continuidad con aparatos mas modernos y sensibles en algun lugar cercano a los epicentros que en nuestro pais afortunadamente se encuentran bien identificados.

Obliteración de fracturas de seno frontal con colgajos pediculados

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J. Pefaure

2014-03-01

Full Text Available El compromiso del seno frontal con fractura de sus paredes es un tipo de lesión infrecuente, en torno al 5-12% de todas las fracturas faciales. Suele asociarse a lesiones intracraneales, oftalmológicas y a otras fracturas máxilofaciales y cuando conlleva fractura de la pared posterior de seno frontal requiere tratamiento inmediato, siendo necesaria la obliteración del seno frontal debido a la comunicación con meninges y lóbulo frontal, con el riesgo infeccioso que ello representa. Tratamos 18 pacientes con traumatismos craneofaciales y fracturas del seno frontal con compromiso de su pared posterior en el periodo comprendido entre 2007 y 2011; 8 mujeres y 10 varones con edades comprendidas entre los 15 y los 64 años. Todos los casos fueron tratados con reducción y osteosíntesis por vía abierta con distintos abordajes y realizamos en todos colgajos pediculados de vecindad. La vitalidad de los colgajos fue del 100% . Certificamos el posicionamiento correcto mediante tomografía axial computarizada. El tratamiento de las fracturas del seno frontal con compromiso de su pared posterior o del conducto nasofrontal requiere obliteración con tejido vascularizado para evitar comunicaciones con la cavidad nasal.

La depleción de las células T regulatorias aumenta el número de las células CD8 durante la infección con el virus del tumor mamario murino

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Gabriel Cabrera

2011-06-01

Full Text Available El virus del tumor mamario murino (MMTV es un retrovirus que se transmite durante la lactancia y que ha desarrollado estrategias para explotar y subvertir el sistema inmune. En un modelo de infección natural con MMTV hemos mostrado previamente que la infección causa incrementos tempranos y progresivos de células T regulatorias (Treg CD4+CD25+Foxp3+ específicas para el superantígeno (Sag viral en las placas de Peyer (PP. En este trabajo se evaluó si la depleción de las células Treg influencia la población de células CD8+ durante la infección con MMTV a través del amamantamiento. La depleción de las células Treg al día 6 de infección causó incrementos en el porcentaje y número absoluto de las células CD8+ en los ganglios y provocó un incremento en la intensidad de fluorescencia media del marcador de activación CD44 en esas células. Los incrementos en el número absoluto de las células CD8 se observaron en células con cadenas variables Vβ del receptor de las células T (TCR tanto reactivas como no reactivas al Sag. Previamente habíamos demostrado que la depleción de las células Treg al día 6 de infección disminuye la carga viral. Los resultados presentados en este trabajo sugieren que, al menos a partir del día 6 de infección con MMTV, las células Treg podrían tener un rol inhibiendo la generación de una respuesta CD8 antiviral.

Mas Gusó: a Roman military Settlement in the suburbium of Emporiae

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Josep Casas Genover

2016-11-01

Full Text Available Although the site of Mas Gusó (province of Girona has been interpreted as a Roman uilla, this is actually a public building. Its existence have to be contextualized within the frame of the structures established by the Roman authority for territorial control closely linked to the creation of a new road network and a tax collection system. We also analyse its survival until the 3rd century AD, which are closely related to the nearby city of Emporiae.

Sharp kink of DNA at psoralen-cross-link site deduced from crystal structure of psoralen-thymine monoadduct

International Nuclear Information System (INIS)

Kim, S.H.; Peckler, S.; Graves, B.; Kanne, D.; Rapoport, H.; Hearst, J.E.

1983-01-01

Light-induced cross-linking of double-stranded nucleic acids by psoralens has been exploited to locate, in vivo or in vitro, those double-helical regions of DNA or RNA that can accommodate any structural changes caused by the psoralen cross-links. To determine three-dimensional structural parameters of the cross-link, we have solved the crystal structure of the psoralen-thymine monoadduct formed in photoreaction between calf thymus DNA and 8-methoxypsoralen (8MOP). There are eight possible configurations for psoralen-thymine monoadducts and 64 for diadducts. We describe here the structural details of a psoralen-thymine monoadduct obtained in a biological environment and the consequences of the photo-cross-link between 8MOP and double-helical DNA

Incidencia y factores asociados con las reacciones adversas del tratamiento antirretroviral inicial en pacientes con VIH

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Juan Astuvilca

2007-07-01

Full Text Available La alta incidencia de reacciones adversas medicamentosas (RAMA al tratamiento antirretroviral de gran actividad (TARGA en pacientes con VIH/SIDA puede afectar la calidad de vida y adherencia al tratamiento. Objetivos: Determinar la incidencia de RAMA del TARGA inicial e identificar los factores asociados con la ocurrencia de RAMA al recibir dicha terapia. Materiales y métodos: Se realizó un estudio de cohorte histórica con todos los pacientes VIH (+ mayores de 18 años que recibieron TARGA por primera vez en el Hospital Nacional Arzobispo Loayza, con un seguimiento de 360 días desde la primera prescripción. Se recabó las RAMA de las historias clínicas y tarjetas de control. Resultados: Se incluyeron 353 pacientes, se encontró una incidencia acumulada de 66,7% de efectos adversos al TARGA inicial y una densidad de incidencia de 9,1 eventos de RAMA por 10 personas año de seguimiento (IC95%: 8,1-10,1. Anemia (23,4%, náuseas (20,6% y rash (17,2% fueron las RAMA más frecuentes. El uso de drogas (OR 2,40; IC95% 1,01-5,67; consumo de alcohol (OR 0.32; IC95%: 0,19-0,55 y estadio SIDA (OR 0,20; IC95%: 0,04-0,95 estuvieron asociadas con la presencia de RAMA. Conclusiones: Existe un alta incidencia de RAMA, siendo la anemia la más frecuente. El uso de drogas es un factor de riesgo para presentar RAMA.

Larvicultura de Rhamdia quelen (Pisces, Pimelodidae con proteína vegetal y animal, suplementadas con plancton

Directory of Open Access Journals (Sweden)

Germán Castañeda A.

2011-12-01

Full Text Available Objetivo. Determinar el efecto de dietas con diferentes proporciones de fuentes proteicas animales y vegetales suplementadas con plancton sobre el crecimiento y sobrevivencia en larvas de Rhamdia quelen. Materiales y métodos. Fueron formuladas dos dietas experimentales, dieta-1 con 70% de proteína de origen vegetal (torta de soya y dieta-2 con 70% de proteína proveniente de animales (corazón bovino yharina de pescado; se utilizaron cuatro protocolos de alimentación (cinco réplicas por tratamiento: dieta-1 + plancton filtrado en tamiz de 50-200 micras (T1, dieta-2 + plancton filtrado en tamiz de 50-200 micras (T2, dieta-1 (T3, dieta-2 (T4. Las larvas fueron manejadas a una densidad de 20 animales L-1 suministrando alimentohasta aparente saciedad diariamente a las 07:00, 11:00, 16:00 y 21:00 horas; la suplementación con plancton se realizó a las 11:00 y 21:00 horas. Resultados. Entre T1 y T2 no se observaron diferencias estadísticas (p>0.05 en peso final (21.89 ± 15.17mg vs 20.37 ± 10.37mg, longitud total (13.41±2.34mm vs 13.39±1.99 mm, factor de condición (K (0.80±0.13 vs 0.78±0.13 y sobrevivencia (46.6±2.68% vs36.0±7.41%; las diferencias entre T3 y T4 tampoco fueron significativas (3.35±1.40 mg vs 2.98±1.48 mg; 7.54±0.91mm vs 7.33±0.96mm; 0.75±0.13 vs 0.71±0.12; 33.6±9.07% vs 24.8±6.76%, respectivamente; hubo diferencias significativas (p<0.05 entre los grupos suplementados con plancton y los alimentados solo con ración. Conclusiones. La suplementación con plancton fue más efectiva que elofrecimiento solo de ración. La inclusión del 62.9% de torta de soya en la formulación (T1, aparentemente no afectó el crecimiento ni la sobrevivencia.

Eventos adversos en 1395 infusiones con diferentes preparados de gammaglobulina intravenosa

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Alejandro Malbrán

2013-10-01

Full Text Available Los procesos de aislamiento y esterilización de la gammaglobulina endovenosa (IVIG afectan las características del producto terminado y, por lo tanto, su tolerabilidad. Distintos productos tienen diferentes incidencias de reacciones adversas. Este trabajo cuantifica los eventos adversos (EA inmediatos provocados por distintas preparaciones de IVIG. Analizamos 1395 infusiones en 28 pacientes, con una mediana de 32.5 por sujeto (rango 2-214, utilizando seis preparados distintos de IVIG, con una dosis total promedio de 40.3 ± 8.3 g. Analizamos retrospectivamente 1 031 infusiones y 364 prospectivamente. Los pacientes utilizaron una media de 2.68 ± 1.8 IVIG diferentes, con una mediana de 2 (rango 1-6 por persona. El número de marcas comerciales utilizadas se relacionó con el número de infusiones recibidas, r = 0.73. En 24 (2.3% de 1031 infusiones analizadas en forma retrospectiva se registraron EA que afectaron a 11 de los 23 casos incluidos, con una media de 2.18 ± 1.08 EA por afectado. De 24 pacientes y de 364 infusiones prospectivas, en 14 pacientes y en 32 (7.2% procedimientos se observaron EA. Veinticuatro (42.9% de 56 EA fueron leves, 31 (55.5% moderados y uno (1.8% fue grave. La velocidad de infusión fue de 9.04 ± 4.6 g/h para las que presentaron EA vs. 10.6 ± 4.6 g/h para las que no (p = 0.31. La incidencia, la gravedad y la proporción de pacientes afectados con EA para cada marca comercial de IVIG fueron muy diferentes entre sí. Esta información debe ser tomada en cuenta en el momento de selección de la IVIG a utilizar.

Fetal betamethasone exposure attenuates angiotensin-(1-7)-Mas receptor expression in the dorsal medulla of adult sheep.

Science.gov (United States)

Marshall, Allyson C; Shaltout, Hossam A; Nautiyal, Manisha; Rose, James C; Chappell, Mark C; Diz, Debra I

2013-06-01

Glucocorticoids including betamethasone (BM) are routinely administered to women entering into early preterm labor to facilitate fetal lung development and decrease infant mortality; however, fetal steroid exposure may lead to deleterious long term consequences. In a sheep model of fetal programming, BM-exposed (BMX) offspring exhibit elevated mean arterial pressure (MAP) and decreased baroreflex sensitivity (BRS) for control of heart rate by 0.5-years of age associated with changes in the circulating and renal renin-angiotensin systems (RAS). In the brain solitary tract nucleus, angiotensin (Ang) II actions through the AT1 receptor oppose the beneficial actions of Ang-(1-7) at the Mas receptor for BRS regulation. Therefore, we examined Ang peptides, angiotensinogen (Aogen), and receptor expression in this brain region of exposed and control offspring of 0.5- and 1.8-years of age. Mas protein expression was significantly lower (>40%) in the dorsal medulla of BMX animals at both ages; however, AT1 receptor expression was not changed. BMX offspring exhibited a higher ratio of Ang II to Ang-(1-7) (2.30±0.36 versus 0.99±0.28; p<0.01) and Ang II to Ang I at 0.5-years. Although total Aogen was unchanged, Ang I-intact Aogen was lower in 0.5-year BMX animals (0.78±0.06 vs. 1.94±0.41; p<0.05) suggesting a greater degree of enzymatic processing of the precursor protein in exposed animals. We conclude that in utero BM exposure promotes an imbalance in the central RAS pathways of Ang II and Ang-(1-7) that may contribute to the elevated MAP and lower BRS in this model. Copyright © 2013 Elsevier Inc. All rights reserved.

A Mission Planning Approach for Precision Farming Systems Based on Multi-Objective Optimization

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Zhaoyu Zhai

2018-06-01

Full Text Available As the demand for food grows continuously, intelligent agriculture has drawn much attention due to its capability of producing great quantities of food efficiently. The main purpose of intelligent agriculture is to plan agricultural missions properly and use limited resources reasonably with minor human intervention. This paper proposes a Precision Farming System (PFS as a Multi-Agent System (MAS. Components of PFS are treated as agents with different functionalities. These agents could form several coalitions to complete the complex agricultural missions cooperatively. In PFS, mission planning should consider several criteria, like expected benefit, energy consumption or equipment loss. Hence, mission planning could be treated as a Multi-objective Optimization Problem (MOP. In order to solve MOP, an improved algorithm, MP-PSOGA, is proposed, taking advantages of the Genetic Algorithms and Particle Swarm Optimization. A simulation, called precise pesticide spraying mission, is performed to verify the feasibility of the proposed approach. Simulation results illustrate that the proposed approach works properly. This approach enables the PFS to plan missions and allocate scarce resources efficiently. The theoretical analysis and simulation is a good foundation for the future study. Once the proposed approach is applied to a real scenario, it is expected to bring significant economic improvement.

Two-Stage MAS Technique for Analysis of DRA Elements and Arrays on Finite Ground Planes

DEFF Research Database (Denmark)

Larsen, Niels Vesterdal; Breinbjerg, Olav

2007-01-01

A two-stage Method of Auxiliary Sources (MAS) technique is proposed for analysis of dielectric resonator antenna (DRA) elements and arrays on finite ground planes (FGPs). The problem is solved by first analysing the DRA on an infinite ground plane (IGP) and then using this solution to model the FGP...

Tratamiento conservador en pacientes con retinoblastoma bilateral

Directory of Open Access Journals (Sweden)

Juan C. Suárez

2008-11-01

Full Text Available OBJETIVO: comparar el tratamiento convencional del retinoblastoma bilateral, usado hasta hace algunos años, consistente en radioterapia o enucleación bilateral, con el tratamiento conservador actual que incluye termoterapia transpupilar (TTT o TTT/quimioterapia al menos en un ojo, en niños con diagnóstico de retinoblastoma bilateral. DISEÑO: estudio retrospectivo descriptivo. MUESTRA: 20 pacientes con diagnóstico de retinoblastoma bilateral que consultaron al Hospital Universitario San Vicente de Paúl, de Medellín, Colombia, entre 1997 y 2007. MÉTODO: se hizo enucleación del ojo con el tumor de mayor tamaño. En el otro ojo se hizo tratamiento con TTT, con el láser diodo (810 nm, spot amplio, solo o combinado con otras terapias. RESULTADOS: se dividió a los pacientes en dos grupos: 16 pacientes (32 ojos en el grupo 1 tratados conservadoramente y 4 pacientes (8 ojos en el grupo 2 con tratamiento convencional. El rango de edad fue de 1-72 meses en el grupo 1 y de 1-12 meses en el grupo 2. El tiempo de seguimiento fue de 7-67 meses para el grupo 1 y de 13-73 meses para el grupo 2. En el grupo 1 se hizo enucleación de 16 ojos (50%, radioterapia externa de uno (3,1%, quimioterapia más termoterapia de 5 (15,6% y quimioterapia más termoterapia más crioterapia de 10 (31,3%. En todos los pacientes se logró preservar al menos un ojo. En el grupo 2, se enuclearon 7 ojos (87,5% y se hizo radioterapia externa más enucleación en un paciente (12.5%. Además, todos los pacientes recibieron quimioterapia. CONCLUSIÓN: la terapia conservadora actual consistente en tratamiento local (termoterapia, crioterapia o braquiterapia y quimiorreducción permite preservar al menos un ojo y en algunos casos de los dos, muchas veces con buena agudeza visual, en niños con retinoblastoma bilateral; se evitan así la enucleación bilateral y la radioterapia externa usada en el tratamiento convencional con todos sus efectos secundarios. La enucleación contin

Protein resonance assignment at MAS frequencies approaching 100 kHz: a quantitative comparison of J-coupling and dipolar-coupling-based transfer methods

Energy Technology Data Exchange (ETDEWEB)

Penzel, Susanne; Smith, Albert A.; Agarwal, Vipin; Hunkeler, Andreas [ETH Zürich, Physical Chemistry (Switzerland); Org, Mai-Liis; Samoson, Ago, E-mail: ago.samoson@ttu.ee [Tallinn University of Technology, NMR Instituut, Tartu Teadus, Tehnomeedikum (Estonia); Böckmann, Anja, E-mail: a.bockmann@ibcp.fr [UMR 5086 CNRS/Université de Lyon 1, Institut de Biologie et Chimie des Protéines (France); Ernst, Matthias, E-mail: maer@ethz.ch; Meier, Beat H., E-mail: beme@ethz.ch [ETH Zürich, Physical Chemistry (Switzerland)

2015-10-15

We discuss the optimum experimental conditions to obtain assignment spectra for solid proteins at magic-angle spinning (MAS) frequencies around 100 kHz. We present a systematic examination of the MAS dependence of the amide proton T{sub 2}′ times and a site-specific comparison of T{sub 2}′ at 93 kHz versus 60 kHz MAS frequency. A quantitative analysis of transfer efficiencies of building blocks, as they are used for typical 3D experiments, was performed. To do this, we compared dipolar-coupling and J-coupling based transfer steps. The building blocks were then combined into 3D experiments for sequential resonance assignment, where we evaluated signal-to-noise ratio and information content of the different 3D spectra in order to identify the best assignment strategy. Based on this comparison, six experiments were selected to optimally assign the model protein ubiquitin, solely using spectra acquired at 93 kHz MAS. Within 3 days of instrument time, the required spectra were recorded from which the backbone resonances have been assigned to over 96 %.

Cleaning of contaminated soils with hydrocarbons by biocell; Saneamiento de suelos contaminados con hidrocarburos mediante biopilas

Energy Technology Data Exchange (ETDEWEB)

Iturbe-Arguelles, R.; Flores-Torres, C; Chavez-Lopez, C.; Roldan-Martin, A [Universidad Nacional Autonoma de Mexico, Mexico, D.F. (Mexico)

2002-03-01

In 1990 the Instituto de Ingenieria de la UNAM, initiated an evaluation through the soil and groundwater sampling and a risk health assessment in a Mexican refinery. An extended area was found contaminated with hydrocarbons. This area requires a soil remediation, taking into account that some zones present more than 30 000 mg/kg of Total Petroleum Hydrocarbons (TPH). Biopile system was recommended as the best remediation method to diminish TPG and some poliaromathic hydrocarbons (PAH). Therefore an experimental biopile of 30 m3 was constructed with contaminated soil. After 22 weeks, results show more than 80 % of TPH and PAH remotion. [Spanish] El grupo de saneamiento de suelos y acuiferos del Instituto de Ingenieria de la UNAM, inicio en 1999 la evaluacion de la contaminacion del subsuelo de una refineria en una zona costera del pais, mediante el muestreo de 425 puntos a 1.5 m de profundidad y con el analisis de los siguientes parametros: hidrocarburos totales del petroleo (HTP), hidrocarburo poliaromaticos (HAP), diesel, gasolina, metilterbutileter (MTBE) y los metales hierro, vanadio, zinc, cadmio, cromo y plomo. Asimismo, se lleva a cabo una evaluacion de riesgo a la salud a fin de determinar los niveles de limpieza de las areas contaminadas. Una vez realizado el estudio se propuso probar a nivel piloto dos tecnicas de saneamiento para las areas contaminadas con valores superiores a 30 000 mg/Kg de http, o bien, para las zonas en donde la evaluacion de riesgo a la salud indica la existencia de riesgo para uno o mas compuestos. Las tecnicas propuesta son biopilas y lavado de suelos con surfactantes. En este trabajo se presenta la prueba piloto con biopilas, de la cual se obtuvo una eficiencia de remocion de http del 80 porciento con cinco meses de operacion. Se muestra las partes de una biopila y se dan los resultados de la biopila experimental en la refineria Francisco I. Madero.

Sorption potential of Moringa oleifera pods for the removal of organic pollutants from aqueous solutions

International Nuclear Information System (INIS)

Akhtar, Mubeena; Moosa Hasany, S.; Bhanger, M.I.; Iqbal, Shahid

2007-01-01

Moringa oleifera pods Lamarck (Drumstick or Horseradish) is a multipurpose medium or small size tree from sub-Himalayan regions of north-west India and indigenous to many parts of Asia, Africa, South America, and in the Pacific and Caribbean Islands. Its pods (MOP) have been employed as an inexpensive and effective sorbent for the removal of organics, i.e., benzene, toluene, ethylbenzene and cumene (BTEC) from aqueous solutions using HPLC method. Effect of different parameters, i.e., sorbent dose 0.05-0.8 g, 25 cm -3 agitation time 5-120 min, pH 1-10, temperature 283-308 K and concentration of sorbate (1.3-13) x 10 -3 , (1.1-11) x 10 -3 , (0.9-9) x 10 -3 , (0.8-8) x 10 -3 mol dm -3 , on the sorption potential of MOP for BTEC have been investigated. The pore area and average pore diameter of the MOP by BET method using nitrogen as a standard are calculated to be 28.06 ± 0.8 m 2 g -1 and 86.2 ± 1.3 nm respectively. Freundlich, Langumir and Dubinin-Radushkevich (D-R) sorption isotherms were employed to evaluate the sorption capacity of MOP. Sorption capacities of BTEC onto MOP have been found to be 46 ± 10, 84 ± 9, 101 ± 4, 106 ± 32 mmol g -1 by Freundlich, 8 ± 0.1, 9 ± 0.1, 10 ± 0.3, 9 ± 0.1 mmol g -1 by Langumir and 15 ± 1, 21 ± 1, 23 ± 2, 22 ± 3 mmol g -1 by D-R isotherms respectively, from BTEC solutions at 303 K. While the mean energy of sorption process 9.6 ± 0.3, 9.2 ± 0.2, 9.3 ± 0.3, 9.5 ± 0.4 kJ mol -1 for BTEC is calculated by D-R isotherm only. Rate constant of BTEC onto MOP 0.033 ± 0.003, 0.030 ± 0.002, 0.029 ± 0.002, 0.027 ± 0.002 min -1 at solution concentration of 1.3 x 10 -3 , 1.1 x 10 -3 , 0.9 x 10 -3 and 0.8 x 10 -3 mol dm -3 and at 303 K have been calculated by employing Lagergren equation. Thermodynamic parameters ΔH -8 ± 0.4, -10 ± 0.6, -11 ± 0.7, -11 ± 0.7 kJ mol -1 , ΔS -22 ± 2, -26 ± 2, -27 ± 2, -29 ± 3 J mol -1 K -1 and ΔG 303K -0.9 ± 0.2, -1.9 ± 0.2, -2.3 ± 0.1 and -2.6 ± 0.2 kJ mol -1 were also estimated

Sorption potential of Moringa oleifera pods for the removal of organic pollutants from aqueous solutions

Energy Technology Data Exchange (ETDEWEB)

Akhtar, Mubeena [National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro-76080 (Pakistan)]. E-mail: profmarao@yahoo.com; Moosa Hasany, S. [Pakistan Institute of Engineering and Applied Sciences, PO Nilore, Islamabad (Pakistan); Bhanger, M.I. [National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro-76080 (Pakistan); Iqbal, Shahid [Department of Chemistry, University of Sargodha, Sargodha-40100 (Pakistan)]. E-mail: ranashahid313@gmail.com

2007-03-22

Moringa oleifera pods Lamarck (Drumstick or Horseradish) is a multipurpose medium or small size tree from sub-Himalayan regions of north-west India and indigenous to many parts of Asia, Africa, South America, and in the Pacific and Caribbean Islands. Its pods (MOP) have been employed as an inexpensive and effective sorbent for the removal of organics, i.e., benzene, toluene, ethylbenzene and cumene (BTEC) from aqueous solutions using HPLC method. Effect of different parameters, i.e., sorbent dose 0.05-0.8 g, 25 cm{sup -3} agitation time 5-120 min, pH 1-10, temperature 283-308 K and concentration of sorbate (1.3-13) x 10{sup -3}, (1.1-11) x 10{sup -3}, (0.9-9) x 10{sup -3}, (0.8-8) x 10{sup -3} mol dm{sup -3}, on the sorption potential of MOP for BTEC have been investigated. The pore area and average pore diameter of the MOP by BET method using nitrogen as a standard are calculated to be 28.06 {+-} 0.8 m{sup 2} g{sup -1} and 86.2 {+-} 1.3 nm respectively. Freundlich, Langumir and Dubinin-Radushkevich (D-R) sorption isotherms were employed to evaluate the sorption capacity of MOP. Sorption capacities of BTEC onto MOP have been found to be 46 {+-} 10, 84 {+-} 9, 101 {+-} 4, 106 {+-} 32 mmol g{sup -1} by Freundlich, 8 {+-} 0.1, 9 {+-} 0.1, 10 {+-} 0.3, 9 {+-} 0.1 mmol g{sup -1} by Langumir and 15 {+-} 1, 21 {+-} 1, 23 {+-} 2, 22 {+-} 3 mmol g{sup -1} by D-R isotherms respectively, from BTEC solutions at 303 K. While the mean energy of sorption process 9.6 {+-} 0.3, 9.2 {+-} 0.2, 9.3 {+-} 0.3, 9.5 {+-} 0.4 kJ mol{sup -1} for BTEC is calculated by D-R isotherm only. Rate constant of BTEC onto MOP 0.033 {+-} 0.003, 0.030 {+-} 0.002, 0.029 {+-} 0.002, 0.027 {+-} 0.002 min{sup -1} at solution concentration of 1.3 x 10{sup -3}, 1.1 x 10{sup -3}, 0.9 x 10{sup -3} and 0.8 x 10{sup -3} mol dm{sup -3} and at 303 K have been calculated by employing Lagergren equation. Thermodynamic parameters {delta}H -8 {+-} 0.4, -10 {+-} 0.6, -11 {+-} 0.7, -11 {+-} 0.7 kJ mol{sup -1}, {delta

Successfully Transitioning from the AA-MAS to the General Assessment. NCEO Policy Directions. Number 22

Science.gov (United States)

Lazarus, Sheryl; Thurlow, Martha; Christensen, Laurene; Shyyan, Vitaliy

2014-01-01

Federal policy initiatives such as the flexibility waivers for accountability are requiring that states transition away from the use of an alternate assessment based on modified achievement standards (AA-MAS). It is expected that those students who had participated in that assessment will instead participate in the state's general assessment (or a…

Análisis del Perfil Cardiovascular en Niños y Adolescentes con epilepsia idiopática

Directory of Open Access Journals (Sweden)

Randy Guerra-Olivares

2014-04-01

Full Text Available Introducción: El uso apropiado de ácido valproico y carbamazepina ha mostrado marcada eficacia para el control de las crisis en pacientes con diagnostico de epilepsia; sin embargo, se ha visto asociado a ciertos efectos secundarios. Entre ellos, cobran especial importancia aquellos que afectan el peso corporal y el perfil bioquímico. Objetivo: Evaluar la presencia de factores de riesgo cardiovasculares en niños y adolescentes diagnosticados con epilepsia idiopática, tratados en monoterapia con ácido valproico o carbamazepina. Métodos: Estudio analítico de corte transversal en niños y adolescentes con diagnóstico de epilepsia en monoterapia con alguna de las dos drogas mencionadas, a quienes se les realizó toma de medidas antropométricas como peso y talla, se calculó índice de masa corporal y se tomaron muestras de sangre para realizar cuantificación en suero de la droga, glucemia y perfiles lipídicos. Resultados: Del total de 30 pacientes, 14 fueron medicados con ácido valproico y 16 con carbamazepina, edad promedio del primer grupo, 9,4 años (IC95% 7,0 a 10,9, 50 % género masculino; (IC95% 26,8 a 73,2 recibiendo dosis promedio de de 26,8 mg/kg/día. Grupo carbamazepina, con edades promedio de 10,3 años (IC95% 8,8 a 11,8, 9 pacientes masculinos (56,3 %; IC95% 33,2 a 76,9 y 7 femeninos (43,7 %; IC95% 23,1 a 66,8, recibiendo dosis promedio de 14,1 mg/kg/día (IC95% 12,6-15.7; mínimo 8,8 y máximo 21,3. Del total de niños 26,7 % presentaban retardo de crecimiento y el 73,3 % normalidad. Todos los casos tuvieron glucemias menores de 100 mg/dL y triglicéridos mayores de 100 mg/dL. En el grupo de carbamazepina, 75% presentaban hipercolesterolemia (≥ 170 mg/dL superior al grupo ácido valproico (21,4 %; 3/14; con diferencia de proporciones (IC95% 18 a 74 %; p = 0,003*. Conclusiones: Los resultados obtenidos sugieren que es necesario considerar las alteraciones del perfi l lipídico en relación del tratamiento con cualquiera de

13C and 15N CP/MAS, 1H-15N SCT CP/MAS and FTIR spectroscopy as tools for qualitative detection of the presence of zwitterionic and non-ionic forms of ansa-macrolide 3-formylrifamycin SV and its derivatives in solid state.

Science.gov (United States)

Przybylski, Piotr; Pyta, Krystian; Klich, Katarzyna; Schilf, Wojciech; Kamieński, Bohdan

2014-01-01

(13)C, (15)N CP/MAS, including (1)H-(13)C and (1)H-(15)N short contact time CP/MAS experiments, and FTIR methods were applied for detailed structural characterization of ansa-macrolides as 3-formylrifamycin SV (1) and its derivatives (2-6) in crystal and in powder forms. Although HPLC chromatograms for 2/CH3 OH and 2/CH3 CCl3 were the same for rifampicin crystals dissolved in respective solvents, the UV-vis data recorded for them were different in 300-375 nm region. Detailed solid state (13)C and (15)N CP/MAS NMR and FTIR studies revealed that rifampicin (2), in contrast to 3-formylrifamycin SV (1) and its amino derivatives (3-6), can occur in pure non-ionic or zwitterionic forms in crystal and in pure these forms or a mixture of them in a powder. Multinuclear CP/MAS and FTIR studies demonstrated also that 3-6 derivatives were present exclusively in pure zwitterionic forms, both in powder and in crystal. On the basis of the solid state NMR and FTIR studies, two conformers of 3-formylrifamycin SV were detected in powder form due to the different orientations of carbonyl group of amide moiety. The PM6 molecular modeling at the semi-empirical level of theory, allowed visualization the most energetically favorable non-ionic and zwitterionic forms of 1-6 antibiotics, strongly stabilized via intramolecular H-bonds. FTIR studies indicated that the originally adopted forms of these type antibiotics in crystal or in powder are stable in standard laboratory conditions in time. The results presented point to the fact that because of a possible presence of two forms of rifampicin (compound 2), quantification of the content of this antibiotic in relevant pharmaceuticals needs caution. Copyright © 2013 John Wiley & Sons, Ltd.

Des schémas équivalents pour les circuits couplés multi-enroulements

Science.gov (United States)

Keradec, J. P.; Cogitore, B.; Laveuve, E.; Bensoam, M.

1994-04-01

The aim of this paper is to represent the electrical behaviour of any number of magnetically coupled windings with couplers and inductors. Two methods, mathematicaly justified, are proposed. The second one introduces only positive inductances. As an exemple, it is applied to the representation of a three column three phase transformer. The obtained circuits supply the requisite guide to design more complete circuits which allow the high frequency behaviour of wound components to be taken into account, especialy in electronics simulation softwares. Le but de cet article est de traduire le comportement électrique d'un nombre quelconque d'enroulements magnétiquement couplés, par des coupleurs et des inductances. Deux méthodes, établies mathématiquement, sont proposées. La seconde n'introduit que des inductances positives. A titre d'exemple, elle est appliquée à la représentation d'un transformateur triphasé à trois colonnes. Les schémas obtenus fournissent l'indispensable ossature de schémas plus complets, aptes à représenter le comportement haute fréquence des composants bobinés, notamment dans un logiciel de simulation électronique.

ANALISIS PERHITUNGAN DAN PELAPORAN PAJAK PERTAMBAHAN NILAI PADA PT FAJAR MAS KARYATAMA

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MARINDO PUTRA

2017-05-01

Full Text Available Value Added Tax (VAT is Tax that imposed on any apreciation in value of the goods or services in its circulation from producers to consumers. Through the calculation dan reporting is good, then the company may be said it has complied with the applicable rules in order to enhance the national development budget of the Government. PT Fajar Mas Karyatama as a company engaged intrade of goods subject to VAT, as in general make a purchase with Input Tax which may be credited. The purpose of this study to know whether the application of VAT and VAT underpayment or overpayment in accordance with law of VAT No. 42 of 2009. This study used a comparative method. The company will account for and report the delivery of Added Value Tax in the Notice Period of Added Value Tax (VAT Period SPT. VAT calculations made by company are the basis for the report required to implement Tax Laws for the companies. Conclusion is that application of VAT in the calculating and reporting of PT Fajar Mas Karyatama was almost accordance with the VAT Act applied and through the application of VAT, namely the purchase and sale of Taxable Goods so that the sum of the difference by the number of Input Tax or Output Tax generate VAT Less/More Pay at the end each mont, it is accordance with the Law of VAT No. 42 of 2009.

Afectividad como mediador de la relación entre optimismo y calidad de vida en hombres que tienen sexo con hombres con VIH

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Pablo Vera-Villarroel

2016-01-01

Full Text Available Antecedente/Objetivos : El aumento de la esperanza de vida ha hecho de la calidad de vida (CV el objetivo fundamental en el cuidado de pacientes crónicos y en personas que viven con VIH. Se ha encontrado evidencia del vínculo entre optimismo, calidad de vida y bienestar. El propósito del presente estudio fue determinar si la afectividad en sus dos dimensiones (positiva y negativa desempeña un rol mediador en la asociación entre op - timismo y calidad de vida en hombres viviendo con VIH que tienen sexo con hombres. Método : Ciento dieciséis hombres con VIH (edad promedio de 36,8 años; DT = 9,06; tiem - po medio desde el diagnóstico de 8,2 años contestaron tres instrumentos: Life Orientation Test Revised Version (LOT-R, Positive and Negative Affect Schedule (PANAS y World Health Organization Quality of Life-Bref (WHOQoL-Bref. Resultados : Los resultados mostraron que el afecto positivo no tuvo efecto mediador, mientras el afecto negativo medió la relación entre optimismo y dos dimensiones de la calidad de vida (calidad de vida general y ambiente. Conclusiones : Se encontró que el afecto negativo participa parcialmente como una variable mediadora entre el optimismo y calidad de vida.

Quality of Kelantan drinking water and knowledge, attitude and practice among the population of Pasir Mas, Malaysia.

Science.gov (United States)

Ab Razak, N H; Praveena, S M; Aris, A Z; Hashim, Z

2016-02-01

Information about the quality of drinking water, together with analysis of knowledge, attitude and practice (KAP) analysis and health risk assessment (HRA) remain limited. The aims of this study were: (1) to ascertain the level of KAP regarding heavy metal contamination of drinking water in Pasir Mas; (2) to determine the concentration of heavy metals (Al, Cr, Cu, Fe, Ni, Pb, Zn and Cd) in drinking water in Pasir Mas; and (3) to estimate the health risks (non-carcinogenic and carcinogenic) caused by heavy metal exposure through drinking water using hazard quotient and lifetime cancer risk. Information on KAP was collected using a standardized questionnaire. Heavy metal analysis of drinking water samples was performed using graphite furnace atomic absorption spectrophotometry. The population of Pasir Mas has good knowledge (80%), a less positive attitude (93%) and good practice (81%) towards heavy metal contamination of drinking water. The concentrations of heavy metals analysed in this study were found to be below the permissible limits for drinking water set by the Malaysian Ministry of Health and the World Health Organization. The HRA showed no potential non-carcinogenic and carcinogenic risks from the intake of heavy metal through drinking water. By investigating the quality of drinking water, KAP and HRA, the results of this study will provide authorities with the knowledge and resources to improve the management of drinking water quality in the future. Copyright © 2015 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

Who Are the Students Who May Qualify for an Alternate Assessment Based on Modified Academic Achievement Standards (AA-MAS)?: Focus Group Results. Synthesis Report 79

Science.gov (United States)

Berndt, Sandra; Ebben, Barbara; Kubinski, Eva; Sim, Grant; Liu, Kristin; Lazarus, Sheryl; Thurlow, Martha; Christian, Elizabeth

2011-01-01

Beginning in 2007, federal regulations to two major education laws gave state departments of education the option to develop an alternate assessment based on modified achievement standards (AA-MAS) for some students with disabilities. The regulations stated that the AA-MAS was intended for students who were being instructed in the grade-level…

Maxillomandibular advancement as the initial treatment of obstructive sleep apnoea: Is the mandibular occlusal plane the key?

Science.gov (United States)

Rubio-Bueno, P; Landete, P; Ardanza, B; Vázquez, L; Soriano, J B; Wix, R; Capote, A; Zamora, E; Ancochea, J; Naval-Gías, L

2017-11-01

Maxillomandibular advancement (MMA) can be effective for managing obstructive sleep apnoea (OSA); however, limited information is available on the predictor surgical variables. This study investigated whether normalization of the mandibular occlusal plane (MOP) was a determinant factor in curing OSA. Patients with moderate or severe OSA who underwent MMA were evaluated by preoperative and postoperative three-dimensional (3D) scans and polysomnograms. The postoperative value of MOP and the magnitude of skeletal advancement were the predictor variables; change in the apnoea-hypopnoea index (AHI) was the main outcome variable. Thirty-four subjects with a mean age of 41±14years and 58,8% female were analysed. The Epworth Sleepiness Scale (ESS) was 17.4±5.4 and AHI was 38.3±10.7 per hour before surgery. Postoperative AHI was 6.5±4.3 per hour (P<0.001) with 52.94% of the patients considered as cured, and 47.06% suffering from a mild residual OSA with ESS 0.8±1.4 (P<0.001). 3D changes revealed a volume increase of 106.3±38.8%. The mandible was advanced 10.4±3.9mm and maxilla 4.9±3.2mm. MOP postoperative value was concluded to be the best predictor variable. Treatment planning should include MOP normalization and a mandibular advancement between 6 and 10mm. The maxillary advancement would depend on the desired aesthetic changes and final occlusion. Copyright © 2017 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

Experimental article – Reducing effective dose to a paediatric phantom by using different combinations of kVp, mAs and additional filtration whilst maintaining image quality

NARCIS (Netherlands)

Elsbeth Huizinga; Ana Pereira; Wouter Schaake; Charlotte Bloomfield; Heidi Knight; Emilie Crausaz; Hanne Hustveit; Ruurd Visser; Vanja Harsaker; Diane Chabloz; Filipa Boavida

2015-01-01

Purpose: To determine whether using different combinations of kVp and mAs with additional filtration can reduce the effective dose to a paediatric phantom whilst maintaining diagnostic image quality. Methods: 27 images of a paediatric AP pelvis phantom were acquired with different kVp, mAs

EFECTO DEL CLIMA SOBRE LA ASOCIACIÓN MICORRÍCICA Y RELACIÓN CON EL ESTADO SANITARIO EN EL ARBOLADO URBANO DE BOGOTÁ D.C.

Directory of Open Access Journals (Sweden)

Carolina Ramos Montaño

2010-01-01

Full Text Available En parques y zonas verdes de Bogotá DC., se evaluó la densidad de esporas y la colonización radical en la rizosfera de tres especies comunes del arbolado urbano: Eugenia myrtifolia, Ficus soatensis y Croton bogotensis, con el fin de determinar si el grado de micorrización está relacionado con el estado sanitarios y si existe diferencias en el grado de micorrización entre dos zonas climáticas distintas. Se comprobó que la especie y el clima son fuentes significativas de variabilidad en el estado general de micorrización; E. myrtifolia presentó la mayor colonización radical promedio pero el mas bajo promedio de densidad de esporas, mientras C. bogotensis tuvo la respuesta contraria; en general los ambientes secos y semisecos favorecieron la micorrización. Sólo en E. myrtifolia se comprobó una relación positiva entre el estado sanitario general y la colonización radicular, y al evaluar la relación con la afectación de síntomas específicos se encontró que la clorosis, la quemazón y la herbivoría mantienen una relación negativa con la micorrización en E. myrtifolia y C. bogotensis. Los resultados sugieren que la asociación con HMA ayuda de algún modo a reducir esos síntomas, presentando un potencial importante para mejorar la sanidad de una de las especies.

Experimental article – Reducing effective dose to a paediatric phantom by using different combinations of kVp, mAs and additional filtration whilst maintaining image quality

NARCIS (Netherlands)

Huizinga, Elsbeth; Schaake, Wouter; Visser, Ruurd; Bloomfield, Charlotte; Boavida, Filipa; Chabloz, Diane; Crausaz, Emilie; Hustveit, Hanne; Knight, Heidi; Pereira, Anna; Harsaker, Vanja

2015-01-01

Purpose: To determine whether using different combinations of kVp and mAs with additional filtration can reduce the effective dose to a paediatric phantom whilst maintaining diagnostic image quality. Methods: 27 images of a paediatric AP pelvis phantom were acquired with different kVp, mAs and

Interneta sociālie tīkli draugiem.lv, mammam/tetiem.lv un twitter.com kā reklāmas nesēji Latvijā (2009.gads)

OpenAIRE

Vismane, Inese

2010-01-01

Maģistra darba tēma ir „Interneta sociālie tīkli draugiem.lv, mammam/tetiem.lv un twitter.com kā reklāmas nesēji Latvijā (2009.gads)”. Darba mērķis ir izpētīt Latvijas interneta sociālo tīklu vidi kā potenciāli augošu un reklāmai piemērotu, kā arī izpētīt pamanāmākos reklāmas gadījumus šajos portālos. Teorijas daļā tiek apskatīta Web 2.0 ēra, interneta reklāmas un sociālo mediju mārketinga īpatnības, sociālo tīklu fenomens un teorijas, Latvijas reklāmas tirgus un auditorija, kā arī sociāl...

Pre- And Post-Enron Learnings On Learning In M&A Environments - A Qualitative Study In Preparation Of A Dissertation On The Influence Of Management Andragogy On Executives Ability To Successfully Manage M&As

OpenAIRE

Jacqueline Fendt

2011-01-01

In a global economy characterized by convergence and consolidation, by shareholder pressure, by the war for talent, for knowledge and for customer bondage, Merger and Acquisition transactions (M&As) are seen as a fast, efficient and spectacular way to innovate. M&As are therefore a frequently used strategic tool for corporate development. However, as of now, more than 75% of all M&As fail to meet objectives and 50% even destroy shareholder value. M&As often fail due to poor leadership. Th...

Characterization of cornelian cherry (Cornus mas L. genotypes - genetic resources for food production in Czech Republic

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Sochor Jiri

2014-01-01

Full Text Available The aim of the study was to determine and compare both technological properties and polyphenol content in fruits of eight cornellian cherry (Cornus mas L. cultivars from Czech Republic. The fruits of cultivar ´Vydubeckij´ had the highest dry matter (17.4% and soluble solid (15.8% content among searched cultivars. The highest crude protein and phosphorus values were determined in the fruits of the ´Titus´ cultivar as 10.9 g of crude protein and 435 mg of phosphorus for per kg fresh weight (FW base. The ´Elegantnyj´ and ´Vydubeckij´ cultivars are found to be more suitable for canning industry. The fruits of the ´Vydubeckij´ cultivar contained 10.8 g of pectin and 22.4 g of citric acid per kg fresh weight base, and could be important for technological use because of their excellent gelling ability. ´Devin´,´Vydubeckij´ and ´Titus´ cultivars had the most valuable source of chlorogenic acid (135.6, 110.9 and 115.1 mg per 100 g FW, respectively and quercetin (24.9, 25.2 and 24.2 mg per 100 g FW, respectively. This work should contribute to the popularization of this fruit specie as a valuable source of technological parameters for human nutrition and the canning industry.

Feminism and Postmodernism in Paloma Díaz-Mas's "The World According to Valdés" and "In Search of a Portrait"

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Fuencisla Zomeño

2002-06-01

Full Text Available This paper analyzes the influence of postmodernism in Paloma Díaz-Mas's feminist approach through two short stories, "The World According to Valdés," and "In Search of a Portrait." The political situation after Franco's death embraced democracy which allowed writers to pay more attention to intellectual concerns. Women writers steered the radical positions of the 1970s toward a more philosophical and intellectual analysis of reality and artistic expression during the eighties. In these two short stories, Díaz-Mas addresses women's issues by questioning the scope of modernist and humanist views. She criticizes the modernist concept of unity (text/identity pointing out the discrimination that this unity creates in art, through the distinction between high art/mass culture; and in the individual, through the distinction between feminine/masculine and high/low. Even though Díaz-Mas's main characters in the two stories are women, she does not solely focus on defending them, but she contrasts present and past to parody the causes which produce discrimination in the social and artistic processes.

Uso de estrategias de gestión directiva, según la “Gestión por 8 hábitos” y su relación con el liderazgo pedagógico

OpenAIRE

Infante Cépeda, Santos Leonardo; Rivera Jiménez, Marco Tulio

2016-01-01

El presente trabajo de investigación consiste en describir la correlación que existe entre las variables Uso de estrategias de gestión directiva, según la “gestión por 8 hábitos” y el liderazgo pedagógico, en el ámbito de la gestión educativa de la escuela privada. La formulación de las hipótesis incluye el cruce de las dimensiones de cada variable, con lo cual a parte de la hipótesis general tiene cuarenta hipótesis con la finalidad de obtener información más precisa para considerar dentro d...

Sobrecarga en el cuidador de paciente con infarto agudo al miocardio

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Norma Lizbeth Ávila Estrada

2012-12-01

Full Text Available Introducción: Las enfermedades cardiovasculares constituyen la primera causa de muerte en México, generando un impacto social persistente que involucra tanto a quien lo padece como a quienes lo rodean. Objetivo: Determinar el nivel de sobrecarga en el cuidador con pacientes de infarto agudo miocardio (IAM en el Hospital General de Durango. Materiales y Métodos: Estudio descriptivo no experimental, transversal; 54 familiares de pacientes hospitalizados con diagnóstico de IAM en el Hospital General Durango, no probabilístico por conveniencia. Resultados: La edad promedio en el estudio es de 18 a 25 años correspondiendo al 37%, de los cuales el 66.7% es femenino, 59.3% tiene escolaridad de medios superior, el 72.2% son de procedencia de la ciudad de Durango, con respecto al parentesco del cuidador con la persona que demanda cuidado esta es en su mayoría hijo con un porcentaje de 20.4%; también un alto porcentaje 81.5 % convive con el enfermo y un 63.0% trabaja fuera del hogar, y un 27.8% ha dejado el trabajo parcialmente; el resultado revelo que existe un nivel medio de sobrecarga del 44.2% en el cuidador primario. Discusión y Conclusiones: Son identificables los niveles de sobrecarga en cuidadores de pacientes con IAM generando una serie de variables que alteran la relación cuidador-paciente trayendo consigo una sobrecarga de tipo medio. (Rev Cuid 2012;3(3:342-8.Palabras clave: Cuidados Posteriores, Absentismo Familiar, Atención no Remunerada. (Fuente: DeCS BIREME.

Resonance Assignments and Secondary Structure Analysis of Dynein Light Chain 8 by Magic-angle Spinning NMR Spectroscopy

Energy Technology Data Exchange (ETDEWEB)

Sun, Shangjin; Butterworth, Andrew H.; Paramasivam, Sivakumar; Yan, Si; Lightcap, Christine M.; Williams, John C.; Polenova, Tatyana E.

2011-08-04

Dynein light chain LC8 is the smallest subunit of the dynein motor complex and has been shown to play important roles in both dynein-dependent and dynein-independent physiological functions via its interaction with a number of its binding partners. It has also been linked to pathogenesis including roles in viral infections and tumorigenesis. Structural information for LC8-target proteins is critical to understanding the underlying function of LC8 in these complexes. However, some LC8-target interactions are not amenable to structural characterization by conventional structural biology techniques owing to their large size, low solubility, and crystallization difficulties. Here, we report magic-angle spinning (MAS) NMR studies of the homodimeric apo-LC8 protein as a first effort in addressing more complex, multi-partner, LC8-based protein assemblies. We have established site-specific backbone and side-chain resonance assignments for the majority of the residues of LC8, and show TALOS+-predicted torsion angles ø and ψ in close agreement with most residues in the published LC8 crystal structure. Data obtained through these studies will provide the first step toward using MAS NMR to examine the LC8 structure, which will eventually be used to investigate protein–protein interactions in larger systems that cannot be determined by conventional structural studies.

con dietas suplementadas con Cromo-L-metionina

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Ram\\u00F3n Garc\\u00EDa-Castillo

2006-01-01

Full Text Available Un total de 48 cerdos (Sus scrofa domesticus; 24 machos castrados y 24 hembras cruzados (Yorkshire, Hampshire, Duroc y Landrace de 3,5 a 4,0 meses de edad y 60,0 ± 5,0 kg PV en finalización. Se alimentaron con dietas isoproteícas (14,5 % PC e isoenergéticas (3.400 kcal EM/kg de MS, adicionadas con Cr-L-metionina (MiCroPlex® (0, 200, 400 y 600 ppb. El experimento tuvo una duración de 45 días y se realizó de agosto a noviembre del 2002 en las instalaciones de la Universidad Autónoma Agraria Antonio Narro, localizada en Saltillo, Coahuila, México. Al tener los animales aproximadamente 95 kg PV, se tomó muestra de 15 ml de sangre por cada animal para determinar la concentración de glucosa, ácido úrico, creatinina, urea, proteinas totales y colesterol. Se aplicó un diseño completamente al azar con arreglo factorial 2 x 4; dos para el factor sexo y cuatro para nivel de cromo. Los metabolitos en suero no fueron afectados (P>0,05 por el factor sexo. La glucosa en suero disminuyó (P<0,05 y el colesterol incrementó (P<0,05 con cromo en la dieta. Se concluye que el Cr incrementa el metabolismo de glucosa y disminuye el de colesterol, con lo cual puede haber energía disponible para síntesis de proteína la cual es necesaria para el crecimiento de los animales

Control y presión al comer en madres de preescolares costarricenses, y su relación con la clase social, la escolaridad, las prácticas de alimentación temprana y el índice de masa corporal de sus hijos e hijas

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Alejandro Chacón-Villalobos

2011-01-01

Full Text Available El objetivo planteado en este trabajo fue el de caracterizar la presion y el control al comer que ejercen madres de preescolares costarricenses de clase alta y baja, evaluando relaciones con el IMC de sus hijos, el tipo de lactancia, la ablactacion, la escolaridad de la madre y su dedicacion al hogar. Para ello se solicito a 102 madres de clase alta y 121 de clase baja completar una encuesta validada (alpha de Cronbach de 0,7 basada en escalas de Likert, para cuantificar, ademas de la informacion general requerida, los niveles de control y presion. Adicionalmente, se determino el IMC segun genero de sus hijos preescolares (102 ninos de clase alta y 103 de clase baja. Para el estudio de los datos se utilizaron pruebas de t-Student y analisis de varianza, asi como correlaciones y evaluaciones de chi cuadrado. Se establecio una tendencia al sobrepeso en ambos sexos en la clase alta, la cual contrasta con las ninas pobres quienes tienden al bajo peso. Se evidencio una mayor frecuencia de trabajo fuera del hogar en la clase baja (p=0,008, siendo la introduccion de alimentos solidos mas temprana (p=0,04. La leche materna fue la opcion mas empleada en ambas clases sociales para el neonato. Ambas clases mostraron "control" y "presión" altas, especialmente entre las madres de clase social baja que trabajan fuera del hogar (p=0,0001. Ambos parametros correlacionan de manera positiva moderada (r=0,44; alpha=0,05. La correlación es mas fuerte entre la clase alta (r=0,54, sobre todo en las niñas (r=0,6.

Síndrome disentérico en un preescolar con colitis ulcerada

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Cecilia Ridaura Sanz

2018-01-01

Full Text Available Niño preescolar de 2 años 3 meses de edad, producto de la primera gesta. Madre de 19 años, ama de casa, escolaridad secundaria; padre de 20 años, soldador, preparatoria incompleta, aparentemente sanos. Se negó consanguinidad y endogamia. Nació a las 40 semanas de gestación, por vía vaginal, con una calificación Apgar de 8/9. Su peso al nacimiento fue de 2.8 kg y midió 51 cm. El tamiz metabólico y auditivo se reportaron normales. Se alimentó al seno materno exclusivo hasta los 6 meses de edad, con alimentación complementaria (papillas de frutas y verduras a los 6 meses, fue integrado a la dieta familiar a los 12 meses. Su desarrollo psicomotor fue referido como normal. Al momento del ingreso con marcha completa y lenguaje al 100%.

MODELAGEM DE UM SISTEMA MULTIAGENTE DE APOIO À PBL UTILIZANDO A METODOLOGIA MAS-COMMONKADS+

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Laysa Mabel de Oliveira Fontes

2014-10-01

Full Text Available A aprendizagem baseada em problema (Problem-Based Learning - PBL é um método no qual os estudantes aprendem através da resolução de um problema que, em geral, não possui uma solução trivial e uma única solução correta. A PBL destaca o trabalho em equipe como um dos principais requisitos para o sucesso do processo de aprendizagem, ou seja, a colaboração é essencial. No entanto, a implantação de um método de ensino com base na PBL não é uma tarefa trivial. Em Ambientes Virtuais de Aprendizagem (AVAs, a complexidade de implantação deste método é ainda maior, pois o facilitador nem sempre pode detectar possíveis problemas na colaboração, nem possui todas as informações necessárias para aplicar as técnicas de aprendizagem deste método. Desta forma, este artigo apresenta o processo de modelagem de um Sistema Multiagente (SMA de apoio à PBL. O SMA proposto foi modelado utilizando a metodologia MAS-CommonKADS+, que consiste em uma extensão da metodologia MAS-CommonKADS.

Phosphole complexes of Gold(I) halides: Comparison of solution and solid-state structures by a combination of solution and CP/MAS 31P NMR spectroscopy and x-ray crystallography

International Nuclear Information System (INIS)

Attar, S.; Nelson, J.H.; Bearden, W.H.; Alcock, N.W.; Alyea, E.C.

1990-01-01

A series of complexes of 1-phenyldibenzophosphole (DBP), 1-phenyl-3,4,-dimethylphosphole (DMPP), and triphenylphosphine of the type L n AuX (n = 1, L = DBP, DMPP, Ph 3 P, X = Cl, Br, I; n = 3, L = DBP, X = Cl, Br, I; n = 3, L = Ph 3 P, X = Cl; n = 4, L = DBP, DMPP, X = PF 6 ) have been prepared and characterized. The structures of (DBP)AuCl (1), (DBP) 3 AuCl (2), and (DMPP)AuCl (3) have been determined from three-dimensional x-ray data collected by counter methods. Crystal structure of the complexes is reported. The CP/MAS 31 P( 1 H) NMR spectrum of complex 1 shows two resonances in a 1:1 intensity ratio, and the CP/MAS 31 P( 1 H) NMR spectrum of complex 3 shows three resonances in a 1:1:1 intensity ratio for reasons that are not yet understood. Though the three phospholes are crystallographically inequivalent (d(AuP) = 2.359 (1), 2.382 (1), and 2.374 (2) angstrom) the molecule has effective C s symmetry as evidenced by the observation of two 31 P resonances in a 2:1 intensity ratio in its CP/MAS 31 P( 1 H) NMR spectrum. Variable-temperature 31 P( 1 H) NMR spectra obtained on solutions of LAuCl + L in various ratios were analyzed to determine the nature of the species present in solution and to gain information regarding their relative stabilities as a function of the nature of the phosphine. 79 refs., 8 figs., 9 tabs

UTILIDAD DEL PERÍMETRO ABDOMINAL COMO MÉTODO DE CRIBAJE DEL SÍNDROME METABÓLICO EN LAS PERSONAS CON HIPERTENSIÓN ARTERIAL

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Roberto Genique Martínez

2010-01-01

Full Text Available Fundamento: Para el diagnóstico de Síndrome Metabólico (SM los criterios mas utilizados son los propuestos, por el ATP-III del NCEP de 2001, actualizados posteriormente en 2005. El perímetro de cintura es uno de los cinco criterios utilizados para su diagnóstico. Dada la elevada incidencia ajustada de enfermedad coronaria atribuible a este factor de riesgo, el objetivo de este trabajo es valorar la utilidad del perímetro de cintura como método de cribaje único de SM en la población con otros factores de riesgo muy prevalentes, como la HTA. Método: Estudio de casos (pacientes hipertensos con SM y controles (pacientes hipertensos sin SM. Mediante muestreo sistemático de la totalidad de individuos hipertensos de un cupo de Atención Primaria con resultados de al menos una analítica sanguínea desde el 1/07/2007 hasta 31/12/2007. El tamaño muestral fue de 137 individuos (casos = pacientes hipertensos con SM = 60 y controles = pacientes hipertensos sin SM=77. Se utilizó el test de regresión logística para el cálculo de la probabilidad de SM disponiendo únicamente del perímetro abdominal. Resultados: Los resultados para el objetivo principal fueron: Probabilidad de SM en población hipertensa=1/(1+2,718281828-(-10+ (perímetro x 0,097, Probabilidad de SM en mujeres hipertensas=1/ (1+2,718281828-(-10+ (perímetro x 0,099, Probabilidad de SM en varones hipertensos=1/(1+2,718281828-(-10+ (perímetro x 0,105. Conclusiones: Utilizando una calculadora podría predecirse la probabilidad de SM en personas hipertensas con el perímetro de cintura como única variable, priorizando mejor a los pacientes con más necesidad preventiva y mayor riesgo cardiovascular. Se propone una tabla con los cálculos ya realizados.

Mitigación de NaCl por efecto de un bioestimulante en la germinación de Ocimum basilicum L.

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Daulemys Batista Sánchez

2017-10-01

Full Text Available Los bioestimulantes vegetales activan el proceso de germinación de las semillas; accionan funciones fisiológicas en las plantas, contienen sustancias propias del metabolismo vegetal, que mejoran el uso de nutrientes y son una opción para mitigar estrés por salinidad. El objetivo del estudio fue evaluar el efecto de un bioestimulante de origen natural (FitoMas-E®, como atenuante de la salinidad en la germinación de las variedades de albahaca (Ocimum basilicum L. Emily, Napoletano y Nufar. Las semillas se sometieron a concentraciones de NaCl (0, 50, 100 y 150 mM y dosis de FitoMas-E® (0, 0.5, 1 y 1.5 mL L-1, en un diseño completamente al azar con arreglo factorial con cuatro repeticiones, en condiciones controladas. Se evaluó porcentaje y tasa de germinación, altura de la plántula, longitud de radícula, biomasa fresca y seca de la radícula, biomasa fresca y seca de la parte aérea. Los resultados mostraron que la altura de la planta, longitud de la radícula, biomasa fresca de parte aérea y biomasa seca de la radícula con 150 mM de NaCl fueron las más dañadas. Napoletano y Nufar mostraron longitud de radícula mayor en 0 mM y conforme la concentración de NaCl incrementó, la longitud de radícula disminuyó significativamente para las tres variedades. Las plántulas de semillas tratadas con FitoMas-E®, incrementaron longitud de radícula, destacando Napoletano en 1 mL L‑1 y Nufar con 0.5 mL L 1. Napoletano mostró biomasa fresca de parte aérea mayor en 0 mM con 0.5 mL L-1 de FitoMas-E®. Las plántulas de Napoletano de semillas tratadas con 0.5 mL L‑1 de FitoMas-E® incrementaron la biomasa seca de radícula en 0 y 50 mM de NaCl. Se concluye que el FitoMas-E® con dosis de 0.5 y 1 mL L-1 mitiga el efecto del estrés salino de moderado a severo en semillas de albahaca.

Cleaning of contaminated grounds with hydrocarbons by means of biopile; Saneamiento de suelos contaminados con hidrocarburos mediante biopilas

Energy Technology Data Exchange (ETDEWEB)

Iturbe Arguelles, R.; Flores Torres, C.; Chavez Lopez, C.; Roldan Martin, A. [Instituto de Ingenieria, UNAM, Mexico, D.F. (Mexico)

2002-03-01

In 1999, the Instituto de Ingenieria of the Universidad Nacional Autonoma de Mexico (UNAM), initiated an evaluation through the soil and groundwater sampling and a risk health assessment in a Mexican refinery. An extended area was found contaminated with hydrocarbons. This area requires a soil remediation, taking into account that some zones present more than 30 000 mg/kg of Total Petroleum Hydrocarbons (TPH). Biopile system was recommended as the best remediation method to diminish TPH and some poliaromathic hydrocarbons (PAH). Therefore, an experimental biopile of 30 m{sup 3} was constructed with contaminated soil. After 22 weeks, results show more than 80% of TPH and PAH remove. [Spanish] El grupo de saneamiento de suelos y acuiferos del Instituto de Ingenieria de la Universidad Nacional Autonoma de Mexico (UNAM), inicio en 1999 la evaluacion de la contaminacion del subsuelo de una refineria en una zona costera del pais, mediante el muestreo de 325 puntos a 1.5 m de profundidad y con el analisis de los siguientes parametros: hidrocarburos totales del petroleo (HTP), hidrocarburos poliaromaticos (HAP), diesel, gasolina, metilterbutileter (MTBE) y los metales hierro, vanadio, zinc, cadmio, cromo y plomo. Asimismo, se llevo a cabo una evaluacion de riesgo a la salud a fin de determinar los niveles de limpieza de las areas contaminadas. Una vez realizado el estudio se propuso probar a nivel piloto dos tecnicas de saneamiento para las areas contaminadas con valores superiores a 30 000 mg/Kg de HTP, o bien, para las zonas en donde la evaluacion de riesgo a la salud indica la existencia de riesgo para uno o mas compuestos (Iturbe et al., 2000). Las tecnicas propuestas son biopilas y lavado de suelo con surfactantes. En este trabajo se presenta la prueba piloto con biopilas, de la cual se obtuvo una eficiencia de remocion de HTP del 80 porciento en cinco meses de operacion.

Abundancia y diversidad larval de gasterópodos en el Caribe Mexicano en relación con la temperatura, la salinidad y el oxígeno disuelto

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José Francisco Chávez Villegas

2014-09-01

Full Text Available Quintana Roo tiene mas de 500 especies de gasterópodos pero muy poco se conoce de los estadios larvales. Muestreamos cuatro sitios mensualmente de enero a diciembre de 2008 con arrastres de plancton por triplicado y con una red cónica con malla de 300μm. Puerto Morelos tuvo los mayores registros (41.26±63.23 larvas•10m-3, seguido por Mahahual (14.78±28.21 larvas•10m-3, Sian Ka’an y Xel-Há presentaron las densidades menores (9.16±16.73 y 3.35±4.33 larvas•10m-3, respectivamente. Mayo y agosto presentaron los mayores registros (33.66±67.39 y 31.78±25.92 larvas•10m-3, respectivamente, marzo y diciembre los menores (1.70±1.88 y 3.18±5.27 larvas•10 m-3 respectivamente. Se registraron diferencias significativas en la densidad media espacial (p:<0.0001 y temporal (p: 0.0275. Identificamos un total de 33 especies de gasterópodos de los géneros Strombus, Natica, Cerithium, Nassarius, Neritidae, Cerithiopsis, Nannodiela, Rissoina, Bulla, Bittium, Modulus y Prunum, de las cuales 28 especies se registraron en Puerto Morelos. Natica, Epithonium y Cerithium fueron los géneros con mayor incidencia en las cuatro localidades.

Delimitando el perfil emotivo-conductual en niños y adolescentes con dislexia

OpenAIRE

Zuppardo, Linda; Serrano, Francisca; Pirrone, Concetta

2017-01-01

La dislexia es una dificultad de aprendizaje caracterizada por una lectura de palabras inexacta o lenta, déficits en decodificación, fluidez lectora y ortografía. Puede conllevar consecuencias emocionales y en el comportamiento, relacionadas con el fracaso escolar. Este trabajo examina estas variables de naturaleza emotivo- conductual de niños y adolescentes con dislexia, en comparación con estudiantes sin problemas de aprendizaje. Treinta y cinco estudiantes (entre 8 y 18 años) fueron evalua...

Cambios en el tono muscular en dos niños con parálisis cerebral espástica mediante la hipoterapia: reporte de casos

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Yasmín Andrea Rodríguez Laiseca

2015-06-01

Full Text Available Introducción: Estudios previos han demostrado que la hipoterapia como terapia complementaria mejora la función motora gruesa en niños con parálisis cerebral. Sin embargo la evidencia no es concluyente. Objetivo: Determinar los cambios en el tono muscular de dos pacientes con parálisis cerebral tipo cuadriparesia espástica mediante la hipoterapia. Descripción del caso: El estudio se llevó a cabo con dos sujetos de género masculino de dos años de edad, con diagnóstico de parálisis cerebral tipo cuadriparesia espástica, nivel V según la escala Gross Motor Function Clasification System (GMFCS. Los niños realizaron 27 sesiones de hipoterapia distribuidas de la siguiente manera: 3 sesiones de acoplamiento en hipoterapia en la primera semana y 24  sesiones de monta terapéutica con una frecuencia de tres veces por semana y una intensidad de 20 minutos por sesión. Se llevó a cabo la valoración del tono muscular mediante la escala de Ashworth modificada (MAS de la siguiente forma: una inicial, dos de control, cuatro post-monta, una final tras 9 semanas de tratamiento continuo y tres mediciones más en la semana uno, dos y tres de inactividad terapéutica. Resultados y discusión: La hipoterapia demostró efecto modulador sobre el tono muscular de los dos sujetos finalizadas las 27 sesiones de hipoterapia, pero este se pierde progresivamente durante el periodo de inactividad terapéutica. Por lo tanto se confirma que esta técnica puede ser una estrategia de tratamiento para el manejo de la espasticidad en pacientes con parálisis cerebral, siempre y cuando se aplique continuamente.

Power quality. Analysis of the losses related to the tension and current distortion in the electric network; Calidad de la energia electrica. Analisis de las perdidas relacionadas con la distorsion de la tension y corriente de la red electrica

Energy Technology Data Exchange (ETDEWEB)

Rauch Sitar, Vladimir [Universidad Autonoma de Queretaro, Facultad de Ingenieria, Queretaro (Mexico)

1994-12-31

In recent times every day one speaks more about power quality and about the losses produced by the tension and current distortion. The distortion in the electric network and the consumption tend to keep on increasing, and each day there will be the need of applying more resources to handle it inside a reasonable range. In this article the situation of the power quality is analyzed in the most general case and also simplified for special cases. On base on the distortion coefficients of tension and current a matrix is created where the harmonics coefficients of tension as well as the current appear in an organized form an all of the elements of that matrix are analyzed. Some topological rules are created in order to give the simplest orientation in the complex situation. The article is useful to supervise the power quality in all of the typical cases and establish a base for a more detailed analysis. [Espanol] En los ultimos tiempos cada dia mas se esta hablando sobre la calidad de la energia electrica (Power Quality) y sobre las perdidas provocadas con este factor. La distorsion de la red electrica y del consumo tiene la tendencia de seguir aumentando y cada dia mas habra que dedicar mas recursos para manejarla dentro de un rango razonable. En el articulo presentado se analiza la situacion de la calidad de energia en caso mas general y tambien simplificada para los casos especiales. A base de coeficientes de distorsion, de tension y corriente se crea una Matriz donde figuran tanto los coeficientes de armonicas de tension como de corriente en una forma ordenada y se analizan todos los elementos de esta matriz. Se crean algunas reglas topologicas para dar la orientacion mas simple en la situacion compleja. El articulo sirve para dar supervision a la calidad de energia en todos los casos tipicos y establecer una base para el analisis mas detallado.

1H HR-MAS NMR Spectroscopy and the Metabolite Determination of Typical Foods in Mediterranean Diet

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Carmelo Corsaro

2015-01-01

Full Text Available NMR spectroscopy has become an experimental technique widely used in food science. The experimental procedures that allow precise and quantitative analysis on different foods are relatively simple. For a better sensitivity and resolution, NMR spectroscopy is usually applied to liquid sample by means of extraction procedures that can be addressed to the observation of particular compounds. For the study of semisolid systems such as intact tissues, High-Resolution Magic Angle Spinning (HR-MAS has received great attention within the biomedical area and beyond. Metabolic profiling and metabolism changes can be investigated both in animal organs and in foods. In this work we present a proton HR-MAS NMR study on the typical vegetable foods of Mediterranean diet such as the Protected Geographical Indication (PGI cherry tomato of Pachino, the PGI Interdonato lemon of Messina, several Protected Designation of Origin (PDO extra virgin olive oils from Sicily, and the Traditional Italian Food Product (PAT red garlic of Nubia. We were able to identify and quantify the main metabolites within the studied systems that can be used for their characterization and authentication.

A new aluminium-hydrate species in hydrated Portland cements characterized by 27Al and 29Si MAS NMR spectroscopy

International Nuclear Information System (INIS)

Andersen, Morten Daugaard; Jakobsen, Hans J.; Skibsted, Jorgen

2006-01-01

Recent 27 Al MAS NMR studies of hydrated Portland cements and calcium-silicate-hydrate (C-S-H) phases have shown a resonance from Al in octahedral coordination, which cannot be assigned to the well-known aluminate species in hydrated Portland cements. This resonance, which exhibits the isotropic chemical shift δ iso = 5.0 ppm and the quadrupole product parameter P Q = 1.2 MHz, has been characterized in detail by 27 Al MAS and 27 Al{ 1 H} CP/MAS NMR for different hydrated white Portland cements and C-S-H phases. These experiments demonstrate that the resonance originates from an amorphous or disordered aluminate hydrate which contains Al(OH) 6 3- or O x Al(OH) 6-x (3+x)- units. The formation of the new aluminate hydrate is related to the formation of C-S-H at ambient temperatures, however, it decomposes by thermal treatment at temperatures of 70-90 o C. From the experiments in this work it is proposed that the new aluminate hydrate is either an amorphous/disordered aluminate hydroxide or a calcium aluminate hydrate, produced as a separate phase or as a nanostructured surface precipitate on the C-S-H phase. Finally, the possibilities of Al 3+ for Ca 2+ substitution in the principal layers and interlayers of the C-S-H structure are discussed

Badania jakości regeneratu ze zużytych mas ze spoiwem organicznym

Directory of Open Access Journals (Sweden)

R. Dańko

2012-12-01

Full Text Available W publikacji przedstawiono uzupełniające metody badań oraz aparaturę do oceny jakości regeneratu i tych właściwości masformierskich ze spoiwami utwardzanymi chemicznie, przygotowywanych z regeneratem, które są istotne dla kompleksowej oceny procesurecyklingu osnowy. Nowoczesne systemy oceny mas formierskich wymagają bardziej wnikliwego podejścia do czynników decydującychzarówno o ich przydatności technologicznej jak również o wpływie na otaczające środowisko naturalne. W tym kontekście pełna ocenajakości zregenerowanej osnowy wykracza poza zwyczajowo stosowane metody instrumentalne i wymaga ich uzupełnienia o bardziejzaawansowane aparaturowo metody badawcze. Pozwala to szerzej spojrzeć na ocenę zregenerowanej osnowy, zarówno w aspekcie jejużycia do sporządzania mas formierskich, jako substytutu świeżego piasku, ale także pod kątem ochrony środowiska. Do takichnowoczesnych metod można zaliczyć między innymi analizę ziarnową regeneratu za pomocą dyfrakcji laserowej, a także ocenęgazotwórczości masy formierskiej oraz identyfikację rodzaju emitowanych gazów i zawartości w nich gazów z grupy BTEX, które sąszczególnie niebezpieczne z punktu widzenia BHP.

Análisis de la coestimulación en la respuesta inmune de pacientes con síndrome de hiperinmunoglobulinemia E con infecciones recurrentes

Directory of Open Access Journals (Sweden)

Pablo Javier Patiño Grajales

2000-02-01

Full Text Available

8.5pt; font-family: Arial">El síndrome de hiperinmunoglobulinemia E con infecciones recurrentes (SHIEIR es una inmunodeficiencia primaria caracterizada por niveles séricos extremadamente elevados de inmunoglobulina E, eczema de aparición temprana, eosinofilia, infecciones a repetición de la piel y neumonías con formación de neumatoceles (1. El análisis reciente de 30 pacientes y 70 de sus familiares ha permitido redefinirlo como un desorden multisistémico que afecta la dentición, el esqueleto, el tejido conectivo y el sistema inmune; se ha sugerido que se hereda como un rasgo autonómico dominante con expresividad variable (2.

8.5pt; font-family: Arial">Las anormalidades inmunológicas en este síndrome incluyen alteraciones del funcionamiento de los linfocitos T y B, al igual que las células fagocíticas. Pese a que dichos defectos no se han logrado documentar consistentemente en todos los pacientes, sí se ha observado de manera persistente una incapacidad de los linfocitos T para activarse, in vivo e in vitro, cuando son estimulados con antígenos específicos, aunque mantienen intacta su capacidad de respuesta a mitógenos. Este fenómeno, aunado a una marcada susceptibilidad de los individuos afectados por adquirir infecciones que comprometen preferencialmente algunos órganos y sistemas (piel y aparato respiratorio y cuyos agentes etiológicos son muy característicos (especialmente el Staphylococcus aureus, nos llevaron a proponer que el defecto en la respuesta inmune en dichos sitios anatómicos y contra microorganismos específicos puede deberse a alguna alteración en las moléculas accesorias que se expresan tanto en los linfocitos T como en las células presentadoras de antígenos.

8.5pt; font-family: Arial">Por lo anterior nos proponemos evaluar la actividad de las mol

Lipid bilayer-bound conformation of an integral membrane beta barrel protein by multidimensional MAS NMR

International Nuclear Information System (INIS)

Eddy, Matthew T.; Su, Yongchao; Silvers, Robert; Andreas, Loren; Clark, Lindsay; Wagner, Gerhard; Pintacuda, Guido; Emsley, Lyndon; Griffin, Robert G.

2015-01-01

The human voltage dependent anion channel 1 (VDAC) is a 32 kDa β-barrel integral membrane protein that controls the transport of ions across the outer mitochondrial membrane. Despite the determination of VDAC solution and diffraction structures, a structural basis for the mechanism of its function is not yet fully understood. Biophysical studies suggest VDAC requires a lipid bilayer to achieve full function, motivating the need for atomic resolution structural information of VDAC in a membrane environment. Here we report an essential step toward that goal: extensive assignments of backbone and side chain resonances for VDAC in DMPC lipid bilayers via magic angle spinning nuclear magnetic resonance (MAS NMR). VDAC reconstituted into DMPC lipid bilayers spontaneously forms two-dimensional lipid crystals, showing remarkable spectral resolution (0.5–0.3 ppm for 13 C line widths and <0.5 ppm 15 N line widths at 750 MHz). In addition to the benefits of working in a lipid bilayer, several distinct advantages are observed with the lipid crystalline preparation. First, the strong signals and sharp line widths facilitated extensive NMR resonance assignments for an integral membrane β-barrel protein in lipid bilayers by MAS NMR. Second, a large number of residues in loop regions were readily observed and assigned, which can be challenging in detergent-solubilized membrane proteins where loop regions are often not detected due to line broadening from conformational exchange. Third, complete backbone and side chain chemical shift assignments could be obtained for the first 25 residues, which comprise the functionally important N-terminus. The reported assignments allow us to compare predicted torsion angles for VDAC prepared in DMPC 2D lipid crystals, DMPC liposomes, and LDAO-solubilized samples to address the possible effects of the membrane mimetic environment on the conformation of the protein. Concluding, we discuss the strengths and weaknesses of the reported

Tagging of blast resistance gene(s) to DNA markers and marker-assisted selection (MAS) in rice improvement

International Nuclear Information System (INIS)

Zhuang, J.Y.; Lu, J.; Qian, H.R.; Lin, H.X.; Zheng, K.L.

1998-01-01

This paper reports progress made on the tagging of blast resistance gene(s) to DNA markers and on the initiation of marker-assisted selection (MAS) for blast resistance in rice improvement. A pair of near isogenic lines, K8OR and K79S, were developed using a Chinese landrace Hong-jiao-zhan as the resistance donor. Ten putatively positive markers were identified by screening 177 mapped DNA markers. Using the F 2 population of 143 plants and the derived F 3 lines, three Restriction Fragment Length Polymorphism (RFLP) markers (RG81, RG869 and RZ397) on chromosome 12 of rice were identified to be closely linked to the blast resistance gene Pi-12(t). The genetic distance between Pi-12(t) and the closest marker RG869 was 5.1 cM. By employing the bulk segregant analysis (BSA) procedure, six of 199 arbitrary primers were found to produce positive Randomly Amplified Polymorphic DNA (RAPD) bands. Tight linkage between Pi-12(t) and three RAPD bands, each from a different primer, was confirmed after amplification of DNA of all F 2 individuals. Two fragments were cloned and sequenced, and two sequence characterised amplified re-ion (SCAR) markers were established. In two other F 3 populations, Xian-feng I/Tetep and Xian-feng, 1/Hong-jiao-zhan, the blast resistance was found to be controlled by interactions of two or more genes. One resistance gene was located in the vicinity of RG81 in both populations. Work to identify other gene(s) is currently under way. Marker assisted selection for blast resistance was initiated. Crosses were made between elite varieties and blast resistance donors to develop populations for DNA marker-assisted selection of blast resistance. In addition, 48 varieties widely used in current rice breeding programs were provided by rice breeders. DNA marker-based polymorphism among, these varieties and resistance donors were analysed to produce a database for future MAS program. (author)

A preliminary study of the relation between adsorption and CP-MAS-NMR characteristics of fused silica model substrates

NARCIS (Netherlands)

Scholten, A.B.; Janssen, J.G.M.; Haan, de J.W.; Cramers, C.A.M.G.; Sandra, P.J.F.; Devos, G.; Sandra, P.

1993-01-01

The fumed silica model substrate Aerosil was trimethylsilylated to different extents and studied by the combination of IGC and 29Si CP-MAS-NMR. Dihydroxydisiloxane groups were shown to be chemically more reactive than monohydroxytrisiloxane groups. Chromatographic experiments showed that these

Angiotensin-converting enzyme 2, Angiotensin-(1-7) and Mas: new players of the Renin Angiotensin System

DEFF Research Database (Denmark)

Santos, Robson AS; Ferreira, Anderson J; Verano-Braga, Thiago

2013-01-01

/proliferative arm of the RAS consisting of ACE, Ang II and AT1 receptor. In this brief review, we will discuss recent findings related to the biological role of the ACE2/Ang-(1-7)/Mas arm in the cardiovascular and renal systems, as well as in metabolism. In addition, we will highlight the potential interactions...

Reklāmas ietekme uz patērētāju izvēles veikšanā

OpenAIRE

Asejevs, Aleksandrs

2012-01-01

Bakalaura darba tēma izvēlēta „Reklāmas ietekme uz patērētāju izvēles veikšanā”. Pastiprinoties konkurencei valstu iekšzemes tirgū, uzņēmumi savas preces un pakalpojumus virza globālajā tirgū. Starptautiskajā mārketingā reklāma tiek izmantota kā viens no mārketinga komunikācijas līdzekļiem, ar kura palīdzību uzņēmumi patērētajiem virzītu savas preces un pakalpojumus. Darba mērķis: balstoties uz veiktās aptaujas rezultātiem, izstrādāt priekšlikumus reklāmas pilnveidošanai Latvijā. Lai...

Citocinas pró-inflamatórias em pacientes com dor neuropática submetidos a tratamento com Tramadol Interleucinas proinflamatorias en pacientes con dolor neuropático sometidos a tratamiento con Tramadol Proinflammatory cytokines in patients with neuropathic pain treated with Tramadol

Directory of Open Access Journals (Sweden)

Durval Campos Kraychete

2009-06-01

Full Text Available JUSTIFICATIVA E OBJETIVOS: As citocinas pró-inflamatórias têm função importante na fisiopatologia das síndromes dolorosas neuropáticas. O objetivo desse estudo foi avaliar os níveis plasmáticos de citocinas pró-inflamatórias antes e após o tratamento com tramadol em pacientes com hérnia discal e síndrome do túnel do carpo e compará-los com indivíduos normais. MÉTODO: Investigou-se 38 pacientes com dor neuropática por hérnia discal ou síndrome do túnel do carpo. Todos os pacientes foram tratados com tramadol de liberação controlada (100 mg em 12h durante 10 dias. Realizaram-se coletas de sangue venoso (5 mL, no período matutino, antes do tratamento e no 11º dia e as amostras foram armazenadas até análise (-70ºC. Foram utilizados testes enzimáticos ELISA para dosagem de citocinas plasmáticas (TNF-±, IL-1, IL-6 e receptores sTNF-R1, (R & D Systems. Realizou-se dosagem de citocinas em soro de 10 voluntários sadios. RESULTADOS: A concentração de TNF-± antes (5,8 ± 2,8 pg.mL-1 foi significativamente maior que após o tramadol (4,8 ± 2,1 pg.mL-1; p = 0,04, Teste Mann-Whitney. Não houve diferença significativa de IL-1², IL-6 e sTNF-R1 antes e após o tratamento. As concentrações plasmáticas de TNF-± (sadios: 1,4 ± 0,5; pacientes com dor: 5,8 ± 2,8 pg.mL-1; p = 0.01 e IL-6 (sadios: 1,2 ± 0,8; pacientes com dor: 3,5 ± 2,6 pg.mL-1; p = 0,01 foram significativamente maiores nos pacientes com dor neuropática que nos voluntários, Teste de Mann-Whitney. CONCLUSÕES: Nos pacientes com hérnia discal e síndrome do túnel do carpo as concentrações plasmáticas de TNF-± e IL-6 foram maiores que em voluntários sadios, não havendo diferença das concentrações de sTNF-R e IL-1². Houve redução da concentração plasmática de TNF-± após tratamento com tramadol (100 mg em 12h, mas não de IL-6, sTNF-R e IL-1².JUSTIFICATIVA Y OBJETIVOS: Las interleucinas proinflamatorias tienen una función importante en

Intracellular accumulation of mannopine, an opine produced by crown gall tumors, transiently inhibits growth of Agrobacterium tumefaciens.

Science.gov (United States)

Kim, K S; Baek, C H; Lee, J K; Yang, J M; Farrand, S K

2001-06-01

pYDH208, a cosmid clone from the octopine-mannityl opine-type tumor-inducing (Ti) plasmid pTi15955 confers utilization of mannopine (MOP) and agropine (AGR) on Agrobacterium tumefaciens strain NT1. NT1 harboring pYDH208 with an insertion mutation in mocC, which codes for MOP oxidoreductase, not only fails to utilize MOP as a sole carbon source, but also was inhibited in its growth by MOP and AGR. In contrast, the growth of mutants with insertions in other tested moc genes was not inhibited by either opine. Growth of strains NT1 or UIA5, a derivative of C58 that lacks pAtC58, was not inhibited by MOP, but growth of NT1 or UIA5 harboring pRE10, which codes for the MOP transport system, was inhibited by the opine. When a clone expressing mocC was introduced, the growth of strain NT1(pRE10) was not inhibited by MOP, although UIA5(pRE10) was still weakly inhibited. In strain NT1(pRE10, mocC), santhopine (SOP), produced by the oxidation of MOP by MocC, was further degraded by functions encoded by pAtC58. These results suggest that MOP and, to a lesser extent, SOP are inhibitory when accumulated intracellularly. The growth of NT1(pRE10), as measured by turbidity and viable cell counts, ceased upon the addition of MOP but restarted in a few hours. Regrowth was partly the result of the outgrowth of spontaneous MOP-resistant mutants and partly the adaptation of cells to MOP in the medium. Chrysopine, isochrysopine, and analogs of MOP in which the glutamine residue is substituted with other amino acids were barely taken up by NT1(pRE10) and were not inhibitory to growth of the strain. Sugar analogs of MOP were inhibitory, and those containing sugars in the D form were more inhibitory than those containing sugars in the L form. MOP analogs containing hexose sugars were more inhibitory than those containing sugars with three, four, or five carbon atoms. Mutants of NT1(pRE10) that are resistant to MOP arose in the zone of growth inhibition. Genetic and physiological analyses

Tratamiento con implantes Leader-Nano en paciente con oligodoncia

Directory of Open Access Journals (Sweden)

Salvador Javier Santos Medina

2015-03-01

Full Text Available Los implantes dentales de titanio han revolucionado el mundo de la rehabilitación desde su surgimiento. De manera particular, el empleo de implantes de carga inmediata acorta el tiempo quirúrgico y protésico, con el consiguiente bienestar estético. Se presenta el caso de una paciente femenina de 32 años de edad, con antecedentes de oligodoncia de ambos incisivos laterales superiores y portadora de prótesis parcial acrílica. Fue atendida por el equipo multidisciplinario de implantes en la Clínica Estomatológica Docente “3 de Octubre” y se le realizó tratamiento de rehabilitación integral con implantes Leader-Nano y prótesis fija con corona acrílica sobre dichos implantes. La implantología fue satisfactoria en la paciente; la mejoría estética y funcional, así como la satisfacción de la paciente, fueron los principales logros obtenidos

Experiencias de haber crecido con un padre/madre con trastorno mental severo (TMS)

OpenAIRE

Vivanco B, Gabriela; Grandón F, Pamela

2016-01-01

Introducción. La experiencia de vivir con personas que presentan un Trastorno Mental Severo (TMS) es difícil para las familias, en especial para los hijos quienes han sido poco estudiados. El objetivo de la investigación fue conocer cómo la experiencia de haber vivido con un padre o madre con un trastorno mental severo influyó en la infancia, adolescencia y adultez joven de sus hijos e hijas. Método. Se analizan las experiencias de convivencia con un padre/madre con TMS en 10 hijos (6 hombres...

1H MAS NMR (magic-angle spinning nuclear magnetic resonance) techniques for the quantitative determination of hydrogen types in solid catalysts and supports.

Science.gov (United States)

Kennedy, Gordon J; Afeworki, Mobae; Calabro, David C; Chase, Clarence E; Smiley, Randolph J

2004-06-01

Distinct hydrogen species are present in important inorganic solids such as zeolites, silicoaluminophosphates (SAPOs), mesoporous materials, amorphous silicas, and aluminas. These H species include hydrogens associated with acidic sites such as Al(OH)Si, non-framework aluminum sites, silanols, and surface functionalities. Direct and quantitative methodology to identify, measure, and monitor these hydrogen species are key to monitoring catalyst activity, optimizing synthesis conditions, tracking post-synthesis structural modifications, and in the preparation of novel catalytic materials. Many workers have developed several techniques to address these issues, including 1H MAS NMR (magic-angle spinning nuclear magnetic resonance). 1H MAS NMR offers many potential advantages over other techniques, but care is needed in recognizing experimental limitations and developing sample handling and NMR methodology to obtain quantitatively reliable data. A simplified approach is described that permits vacuum dehydration of multiple samples simultaneously and directly in the MAS rotor without the need for epoxy, flame sealing, or extensive glovebox use. We have found that careful optimization of important NMR conditions, such as magnetic field homogeneity and magic angle setting are necessary to acquire quantitative, high-resolution spectra that accurately measure the concentrations of the different hydrogen species present. Details of this 1H MAS NMR methodology with representative applications to zeolites, SAPOs, M41S, and silicas as a function of synthesis conditions and post-synthesis treatments (i.e., steaming, thermal dehydroxylation, and functionalization) are presented.

Revisión: Spongospora subterranea f.sp. subterranea y su Virus Asociado Potato mop-top virus (PMTV, Dos Patógenos Reemergentes en los Cultivos de Papa de Colombia Review: Spongospora subterranea f.sp. subterranea and its Associated Virus Potato mop-top virus (PMTV, Two Re-emerging Pathogens of Potato Crops in Colombia

Directory of Open Access Journals (Sweden)

Inés Osorio Giraldo

2012-06-01

Full Text Available Resumen. El cultivo de papa es uno de los renglones agrícolas de mayor importancia en Colombia; se extiende a 128.701 ha y genera una producción anual de 2,3 millones de t año-1. Desde el punto vista fitosanitario, la papa se ve afectada por diversos problemas, destacándose en los últimos años la reemergencia de la sarna polvosa causada por el protozoario del suelo Spongospora subterranea f.sp. subterranea (Sss. El efecto de esta enfermedad se refleja en el deterioro de la calidad del tubérculo y en la reducción de la producción, al afectar el sistema radicular y los tubérculos. Además, Sss es el vector natural del Potato mop-top virus (PMTV, uno de los virus prevalentes en la región Andina y que presenta carácter cuarentenario en diferentes países del mundo. En esta revisión se presenta el estado de conocimiento que se tiene en el mundo sobre éstos dos fitopatógenos, haciendo énfasis en los principales hallazgos que se han realizado en Colombia sobre sus niveles de variación genética, efecto sobre la producción y métodos de detección. Se espera que la información presentada, llame la atención a los organismos estatales de sanidad vegetal, gremios de productores, asistentes técnicos y agricultores, sobre la importancia creciente que presentan dichos patógenos en los sistemas de producción de papa. Además, que sirva de base para el diseño de herramientas de diagnóstico que apoyen los esquemas de certificación de tubérculo semilla y los programas de mejoramiento genético de papa que se adelantan en Colombia.Abstract. Potato is one of the most important crops in Colombia, comprising 128.701 ha and a total production of 2.3 million t year-1. There are several phytopathological problems affecting this crop, however, the soil protozoan Spongospora subterranea f.sp. subterranea (Sss, the causal agent of powdery scab, stands out due to its recent reemergence. Powdery scab can seriously deteriorate tuber quality and

Genotyping-by-sequencing (GBS), an ultimate marker-assisted selection (MAS) tool to accelerate plant breeding

OpenAIRE

He, Jiangfeng; Zhao, Xiaoqing; Laroche, André; Lu, Zhen-Xiang; Liu, HongKui; Li, Ziqin

2014-01-01

Marker-assisted selection (MAS) refers to the use of molecular markers to assist phenotypic selections in crop improvement. Several types of molecular markers, such as single nucleotide polymorphism (SNP), have been identified and effectively used in plant breeding. The application of next-generation sequencing (NGS) technologies has led to remarkable advances in whole genome sequencing, which provides ultra-throughput sequences to revolutionize plant genotyping and breeding. To further broad...

Floor cleaning: effect on bacteria and organic materials in hospital rooms.

Science.gov (United States)

Andersen, B M; Rasch, M; Kvist, J; Tollefsen, T; Lukkassen, R; Sandvik, L; Welo, A

2009-01-01

Routine surface cleaning is recommended to control the spread of pathogens in hospital environments. In Norway, ordinary cleaning of patient rooms is traditionally performed with soap and water. In this study, four floor-mopping methods--dry, spray, moist and wet mopping--were compared by two systems using adenosine triphosphate (ATP) bioluminescence (Hygiena and Biotrace). These systems assess residual organic soil on surfaces. The floor-mopping methods were also assessed by microbiological samples from the floor and air, before and after cleaning. All methods reduced organic material on the floors but wet and moist mopping seemed to be the most effective (P < 0.001, P < 0.011, respectively, ATP Hygiena). The two ATP methods were easy to use, although each had their own reading scales. Cleaning reduced organic material to 5-36% of the level present before cleaning, depending upon mopping method. All four mopping methods reduced bacteria on the floor from about 60-100 to 30-60 colony-forming units (cfu)/20cm2 floor. Wet, moist and dry mopping seemed to be more effective in reducing bacteria on the floor, than the spray mopping (P=0.007, P=0.002 and P=0.011, respectively). The burden of bacteria in air increased for all methods just after mopping. The overall best cleaning methods seemed to be moist and wet mopping.

WASP-12b AND HAT-P-8b are members of triple star systems

Energy Technology Data Exchange (ETDEWEB)

Bechter, Eric B.; Crepp, Justin R.; Matthews, Christopher T. [Department of Physics, University of Notre Dame, 225 Nieuwland Science Hall, Notre Dame, IN 46556 (United States); Ngo, Henry; Knutson, Heather A.; Batygin, Konstantin; Johnson, John Asher [Department of Planetary Science, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125 (United States); Hinkley, Sasha; Muirhead, Philip S.; Montet, Benjamin T.; Morton, Timothy D. [Department of Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125 (United States); Howard, Andrew W., E-mail: ebechter@nd.edu [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States)

2014-06-10

We present high spatial resolution images that demonstrate that WASP-12b and HAT-P-8b orbit the primary stars of hierarchical triple star systems. In each case, two distant companions with colors and brightnesses consistent with M dwarfs co-orbit the hot Jupiter planet host as well as one another. Our adaptive optics images spatially resolve the secondary around WASP-12, previously identified by Bergfors et al. and Crossfield et al. into two distinct sources separated by 84.3 ± 0.6 mas (21 ± 3 AU). We find that the secondary to HAT-P-8, also identified by Bergfors et al., is in fact composed of two stars separated by 65.3 ± 0.5 mas (15 ± 1 AU). Our follow-up observations demonstrate physical association through common proper motion. HAT-P-8 C has a particularly low mass, which we estimate to be 0.18 ± 0.02 M {sub ☉} using photometry. Due to their hierarchy, WASP-12 BC and HAT-P-8 BC will enable the first dynamical mass determination for hot Jupiter stellar companions. These previously well studied planet hosts now represent higher-order multi-star systems with potentially complex dynamics, underscoring the importance of diffraction-limited imaging and providing additional context for understanding the migrant population of transiting hot Jupiters.

WASP-12b and HAT-P-8b are Members of Triple Star Systems

Science.gov (United States)

Bechter, Eric B.; Crepp, Justin R.; Ngo, Henry; Knutson, Heather A.; Batygin, Konstantin; Hinkley, Sasha; Muirhead, Philip S.; Johnson, John Asher; Howard, Andrew W.; Montet, Benjamin T.; Matthews, Christopher T.; Morton, Timothy D.

2014-06-01

We present high spatial resolution images that demonstrate that WASP-12b and HAT-P-8b orbit the primary stars of hierarchical triple star systems. In each case, two distant companions with colors and brightnesses consistent with M dwarfs co-orbit the hot Jupiter planet host as well as one another. Our adaptive optics images spatially resolve the secondary around WASP-12, previously identified by Bergfors et al. and Crossfield et al. into two distinct sources separated by 84.3 ± 0.6 mas (21 ± 3 AU). We find that the secondary to HAT-P-8, also identified by Bergfors et al., is in fact composed of two stars separated by 65.3 ± 0.5 mas (15 ± 1 AU). Our follow-up observations demonstrate physical association through common proper motion. HAT-P-8 C has a particularly low mass, which we estimate to be 0.18 ± 0.02 M ⊙ using photometry. Due to their hierarchy, WASP-12 BC and HAT-P-8 BC will enable the first dynamical mass determination for hot Jupiter stellar companions. These previously well studied planet hosts now represent higher-order multi-star systems with potentially complex dynamics, underscoring the importance of diffraction-limited imaging and providing additional context for understanding the migrant population of transiting hot Jupiters.

WASP-12b AND HAT-P-8b are members of triple star systems

International Nuclear Information System (INIS)

Bechter, Eric B.; Crepp, Justin R.; Matthews, Christopher T.; Ngo, Henry; Knutson, Heather A.; Batygin, Konstantin; Johnson, John Asher; Hinkley, Sasha; Muirhead, Philip S.; Montet, Benjamin T.; Morton, Timothy D.; Howard, Andrew W.

2014-01-01

We present high spatial resolution images that demonstrate that WASP-12b and HAT-P-8b orbit the primary stars of hierarchical triple star systems. In each case, two distant companions with colors and brightnesses consistent with M dwarfs co-orbit the hot Jupiter planet host as well as one another. Our adaptive optics images spatially resolve the secondary around WASP-12, previously identified by Bergfors et al. and Crossfield et al. into two distinct sources separated by 84.3 ± 0.6 mas (21 ± 3 AU). We find that the secondary to HAT-P-8, also identified by Bergfors et al., is in fact composed of two stars separated by 65.3 ± 0.5 mas (15 ± 1 AU). Our follow-up observations demonstrate physical association through common proper motion. HAT-P-8 C has a particularly low mass, which we estimate to be 0.18 ± 0.02 M ☉ using photometry. Due to their hierarchy, WASP-12 BC and HAT-P-8 BC will enable the first dynamical mass determination for hot Jupiter stellar companions. These previously well studied planet hosts now represent higher-order multi-star systems with potentially complex dynamics, underscoring the importance of diffraction-limited imaging and providing additional context for understanding the migrant population of transiting hot Jupiters.

Lithium ion mobility in lithium phosphidosilicates: Crystal structure, {sup 7}Li, {sup 29}Si, and {sup 31}P MAS NMR spectroscopy, and impedance spectroscopy of Li{sub 8}SiP{sub 4} and Li{sub 2}SiP{sub 2}

Energy Technology Data Exchange (ETDEWEB)

Toffoletti, Lorenzo; Landesfeind, Johannes; Klein, Wilhelm; Gasteiger, Hubert A.; Faessler, Thomas F. [Department of Chemistry, Technische Universitaet Muenchen, Lichtenbergstrasse 4, 85747, Garching bei Muenchen (Germany); Kirchhain, Holger; Wuellen, Leo van [Department of Physics, University of Augsburg, Universitaetsstrasse 1, 86159, Augsburg (Germany)

2016-12-05

The need to improve electrodes and Li-ion conducting materials for rechargeable all-solid-state batteries has drawn enhanced attention to the investigation of lithium-rich compounds. The study of the ternary system Li-Si-P revealed a series of new compounds, two of which, Li{sub 8}SiP{sub 4} and Li{sub 2}SiP{sub 2}, are presented. Both phases represent members of a new family of Li ion conductors that display Li ion conductivity in the range from 1.15(7) x 10{sup -6} Scm{sup -1} at 0 C to 1.2(2) x 10{sup -4} Scm{sup -1} at 75 C (Li{sub 8}SiP{sub 4}) and from 6.1(7) x 10{sup -8} Scm{sup -1} at 0 C to 6(1) x 10{sup -6} Scm{sup -1} at 75 C (Li{sub 2}SiP{sub 2}), as determined by impedance measurements. Temperature-dependent solid-state {sup 7}Li NMR spectroscopy revealed low activation energies of about 36 kJ mol{sup -1} for Li{sub 8}SiP{sub 4} and about 47 kJ mol{sup -1} for Li{sub 2}SiP{sub 2}. Both compounds were structurally characterized by X-ray diffraction analysis (single crystal and powder methods) and by {sup 7}Li, {sup 29}Si, and {sup 31}P MAS NMR spectroscopy. Both phases consist of tetrahedral SiP{sub 4} anions and Li counterions. Li{sub 8}SiP{sub 4} contains isolated SiP{sub 4} units surrounded by Li atoms, while Li{sub 2}SiP{sub 2} comprises a three-dimensional network based on corner-sharing SiP{sub 4} tetrahedra, with the Li ions located in cavities and channels. (copyright 2016 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim)

Portadores nasofaríngeos de Neisseria meningitidis en trabajadores con riesgo ocupacional

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Isabel Martínez

2010-04-01

Full Text Available Los portadores de Neisseria meningitidis constituyen la principal fuente de infección y transmisión de la enfermedad meningocócica. Conocer su prevalencia, las características de las cepas aisladas y los factores de riesgos asociados con el estado de portador, aportan datos valiosos al control y vigilancia epidemiológica de esta entidad clínica. Para cumplimentar los objetivos propuestos se realizó un estudio transversal descriptivo de portadores de N. meningitidis en 112 trabajadores de un centro de producción de biofarmacéuticos de La Habana, con edades comprendidas entre 18_60 años. Previo a su realización se cumplió con las exigencias bioéticas requeridas para este tipo de estudio. A todos se les realizó un exudado nasofaríngeo y una encuesta, donde se indagó sobre factores de riesgo (edad, sexo, hacinamiento, hábito de fumar, consumo de bebidas alcohólicas, amigdalectomía y antecedentes de infección respiratoria que favorecen la condición del portador. La identificación de las cepas de N. meningitidis se realizó según métodos convencionales, la clasificación de los serogrupos se hizo por aglutinación en láminas portaobjetos con antisueros comerciales y para la identificación de los serotipos y subtipos se empleó un ensayo inmunoenzimático (ELISA de células enteras con anticuerpos monoclonales. Se detectó un 8% de portadores de N. meningitidis con predominio del serogrupo B (77,8% y el fenotipo más frecuente fue el B:4:P1.4 (33,3%. Al analizar el estado de portador y su asociación con los factores de riesgo, la edad (p = 0,05 y el sexo (p = 0,013 mostraron diferencias significativas. Se demostró la posibilidad del riesgo ocupacional en aquellos individuos que por su profesión están en contacto con microorganismos patógenos

Estimación de parámetros químicos y biológicos en oxisoles con uso citrícola Estimation of chemical and biological parameters on oxisols with Citrus

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Humberto C Dalurzo

2005-12-01

Full Text Available El objetivo de este estudio fue estimar el efecto del sistema de producción citrícola sobre algunas propiedades químicas y biológicas del suelo, a fin de obtener indicadores de calidad. Se estableció un ensayo con 2 tratamientos: selva subtropical (Sv y uso citrícola (Ci. El diseño fue en bloques completamente aleatorizados. Se tomaron muestras compuestas de 0-10 cm de profundidad. Se determinaron: pH, carbono orgánico (CO, materia orgánica particulada (MOP, fósforo asimilable (P, nitrógeno total (Nt, nitrógeno potencialmente mineralizable (NPM, actividad de la fosfatasa ácida (APA, y respiración del suelo (RES como variables de respuesta. El contenido promedio de CO fue mayor en la Sv (4,03 % respecto al Ci (2,35%. A pesar del aporte de N al Citrus, el Nt y el Npm fueron mayores en la Sv. En la MOP y sus fracciones, se hallaron diferencias significativas presentando la Sv los mayores valores. El Nt explicó el 69% de la variancia de la APA y el CO el 61%: APA = 1.775 N 153,7 (r² = 0,.69. APA = 221 CO - 230 (r² = 0.61. La disminución producida por el uso citrícola revelaría que los atributos: CO, Nt, APA, NPM, MOP y RES, serían indicadores sensibles de la calidad del suelo.Knowledge about the impact of agricultural practices on soil quality is very important to plan the use and sustainable management of productive lands. Citrus cropping has recently acquired a significant economic importance in Misiones, Argentina. It is cultivated in different types of soils sensitive to erosion, like Oxisoles. The aim of this work was to determine the effect of citrus cropping on some chemical and biological soil quality indicators. The field experiment consisted of 2 treatments: subtropical rainforest (Sv and citrus (Ci. In 0-10 cm samples the following parameters were measured: pH, organic carbon (OC, particulate organic matter (POM, total nitrogen (TN, available phosphorus (P, acid phosphatase activity (APA, respiration (RES, and

Riesgo de enfermedad tuberculosa en pacientes con artritis reumatoide

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Rocío Gamboa

2006-10-01

Full Text Available Antecedentes: Los estudios sobre riesgo de enfermedad tuberculosa (ET en artritis reumatoide (AR en pacientes no usuarios de terapia biológica son controversiales. Objetivo: Evaluar AR como factor de riesgo independiente para ET. Diseño: Estudio de cohortes no concurrente. Lugar: Red asistencial Hospital Guillermo Almenara Irigoyen, Lima-Perú, hospital docente. Participantes: Pacientes con AR no usuarios de terapia biológica. Intervenciones: Una cohorte de pacientes con AR no usuarios de terapia biológica (cumplimiento de criterios 1987 del ACR fue pareada por edad y género con una cohorte control (pacientes con trastornos no inmunológicos. Se realizó una entrevista personal. El seguimiento para la cohorte AR se inició en el diagnostico de AR y culminó en el momento de la entrevista o en el diagnóstico de ET (los controles fueron seguidos el mismo periodo de tiempo. Se calculó la densidad de incidencia (DI para ET en cada cohorte y el riesgo relativo (RR. La probabilidad de ET de acuerdo al tiempo de enfermedad fue comparada mediante curvas de Kaplan Meier. Se aplicó un modelo de Cox para ajustar drogas y patologías predisponentes (hazard ratio -HR. Principales medidas de resultados: Enfermedad tuberculosa en pacientes con artritis reumatoide. Resultados: La cohorte AR y los controles (667 y 664 pacientes, respectivamente tuvieron 6 940,75 y 6 666,53 personas-año de seguimiento. La edad al diagnóstico de AR fue 46,65 años. Un 29,7% de 195 pacientes AR fueron PPD positivos. Quince pacientes AR y ocho controles desarrollaron ET (DI de 216,1/100 000 y 122,1/100 000 personas/año. El RR para TBC fue 1,8 (IC 95% = 0,8-4,2 y luego del ajuste para drogas y comorbilidades predisponentes de ET, el HR fue 1,69 (IC 95%=0,26-10,93. No hubo diferencia al comparar las curvas de Kaplan Meier (p=0,19. Conclusiones: La incidencia de ET entre los pacientes con AR fue mayor que en los pacientes sin dicha condición; sin embargo, esta diferencia no

Estabilidad oxidativa de huevos enriquecidos con ácidos grasos poliinsaturados omega 3, frente a antioxidantes naturales Estabilidade oxidativa de ovos enriquecidos com ácidos graxos poliinsaturados ômega 3, frente a antioxidantes naturais

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María Elena Bernal Gómez

2003-12-01

Full Text Available Fueron alimentadas 192 gallinas ponedoras de 22 semanas de edad, de linaje comercial Babcock, durante 30 días con dietas de 0 (cero y 12,7% de semilla de linaza molida que corresponde a 0 y 5% de aceite de linaza, respectivamente. Fueron definidos 8 tratamientos: 4 grupos con 12,7% de semilla de linaza (control/sin antioxidante; BHA+BHT, 100+100 ppm; orégano, 200 ppm; romero, 200 ppm y 4 grupos sin semilla de linaza, pero utilizando los mismos antioxidantes. Este estudio fue realizado con el objetivo de verificar la eficacia del uso de antioxidantes naturales provenientes del orégano y del romero en la protección contra el deterioro oxidativo de la fracción lipídica de las yemas de los huevos enriquecidos con ácidos grasos poliinsaturados omega 3 (PUFA É-3. El grado de oxidación lipídica fue determinado a través de la prueba TBARS (substancias reactivas con ácido tiobarbitúrico. Según los resultados obtenidos, fue verificada diferencia significativa en la reducción del grado de oxidación lipídica de las yemas de huevo en todos los tratamientos con antioxidantes, cuando se compara con el control. Por lo tanto, los extratos de los condimentos, romero y orégano, pueden ser utilizados satisfactoriamente para obtener huevos enriquecidos con PUFA É-3, mejorando la estabilidad lipídica.Foram alimentadas 192 galinhas poedeiras de 22 semanas de idade da linhagem comercial Babcock, durante 30 dias com dietas constituídas de 0 (zero e 12,7% de semente de linhaça moída correspondente a 0 e 5% de óleo de linhaça, respectivamente. Foram definidos 8 tratamentos: 4 grupos com 5% de óleo de linhaça (controle/sem antioxidante; BHA+BHT, 100+100 ppm; orégano, 200 ppm; alecrim, 200 ppm e 4 grupos sem óleo de linhaça, mas utilizando os mesmos antioxidantes. Este estudo foi realizado com o objetivo de verificar a eficácia do uso de antioxidantes naturais provenientes do orégano e do alecrim, na proteção contra a deteriora

Evaluación de mezclas formuladas de fertilizantes con dosis crecientes y aplicación de materia orgánica en el rendimiento de tabaco negro en un suelo arenoso bajo condiciones de invernadero

Directory of Open Access Journals (Sweden)

Aníbal Cóndor G

2013-06-01

Full Text Available El presente trabajo compara tres mezclas formuladas de fertilizantes —una mezcla tradicional; un fertilizante mineral 10-15-20; y un fertilizante orgánico-mineral 8-12-16 en dosis crecientes, con y sin aplicación de materia orgánica (humus de lombriz— en el cultivo de tabaco. El experimento se condujo en un suelo arenoso de irrigación utilizando 2 plántulas de tabaco negro por maceta. La fertilización al suelo para cada dosis de NPK en mg.kg-1/maceta fue: dosis baja (160-60-80, dosis media (320-120-160 y dosis alta (480-180-240. Se utilizó el diseño completo al azar con arreglo factorial, con tres repeticiones y conducido en macetas con 4 kg de suelo. La evaluación consistió en medir el rendimiento en peso fresco de la parte aérea y el peso seco total (parte aérea y radicular de las plantas. Fue posible observar que no existe superioridad en cuanto a la materia fresca y seca total producidas entre las mezclas formuladas utilizadas, con un promedio de 432,5g/maceta y 112,6g/ maceta, respectivamente. Se pudo tener así tres alternativas en la fertilización de tabaco. Sin embargo, con el uso del fertilizante orgánico-mineral se obtendría mayores beneficios en el suelo por el efecto residual que dejaría por contener en su composición un 25% de materia orgánica por cada 100 kg de fertilizante. Conforme aumentan las dosis de fertilización se incrementan también los rendimientos, notándose el efecto directo de los fertilizantes en el sustrato arenoso utilizado, sin salinidad que pueda haber afectado la asimilación de nutrientes. Además, se observó la baja fertilidad del sustrato al comparar el tratamiento adicional 0-0-0 con los demás tratamientos, lo que ha producido mas del 300% en cuanto a rendimiento. No existe efecto significativo en la interacción fertilizante vs. materia orgánica en la producción de materia fresca aérea y seca total, debido a que la dosis de materia orgánica fue baja (1%.

Genotyping by sequencing (GBS, an ultimate marker-assisted selection (MAS tool to accelerate plant breeding

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Jiangfeng eHe

2014-09-01

Full Text Available Marker-assisted selection (MAS refers to the use of molecular markers to assist phenotypic selections in crop improvement. Several types of molecular markers, such as single nucleotide polymorphism (SNP, have been identified and effectively used in plant breeding. The application of next-generation sequencing (NGS technologies has led to remarkable advances in whole genome sequencing, which provides ultra-throughput sequences to revolutionize plant genotyping and breeding. To further broaden NGS usages to large crop genomes such as maize and wheat, genotyping by sequencing (GBS has been developed and applied in sequencing multiplexed samples that combine molecular marker discovery and genotyping. GBS is a novel application of NGS protocols for discovering and genotyping SNPs in crop genomes and populations. The GBS approach includes the digestion of genomic DNA with restriction enzymes followed by the ligation of barcode adapter, PCR amplification and sequencing of the amplified DNA pool on a single lane of flow cells. Bioinformatic pipelines are needed to analyze and interpret GBS datasets. As an ultimate MAS tool and a cost-effective technique, GBS has been successfully used in implementing genome-wide association study (GWAS, genomic diversity study, genetic linkage analysis, molecular marker discovery and genomic selection (GS under a large scale of plant breeding programs.

Genotyping-by-sequencing (GBS), an ultimate marker-assisted selection (MAS) tool to accelerate plant breeding.

Science.gov (United States)

He, Jiangfeng; Zhao, Xiaoqing; Laroche, André; Lu, Zhen-Xiang; Liu, HongKui; Li, Ziqin

2014-01-01

Marker-assisted selection (MAS) refers to the use of molecular markers to assist phenotypic selections in crop improvement. Several types of molecular markers, such as single nucleotide polymorphism (SNP), have been identified and effectively used in plant breeding. The application of next-generation sequencing (NGS) technologies has led to remarkable advances in whole genome sequencing, which provides ultra-throughput sequences to revolutionize plant genotyping and breeding. To further broaden NGS usages to large crop genomes such as maize and wheat, genotyping-by-sequencing (GBS) has been developed and applied in sequencing multiplexed samples that combine molecular marker discovery and genotyping. GBS is a novel application of NGS protocols for discovering and genotyping SNPs in crop genomes and populations. The GBS approach includes the digestion of genomic DNA with restriction enzymes followed by the ligation of barcode adapter, PCR amplification and sequencing of the amplified DNA pool on a single lane of flow cells. Bioinformatic pipelines are needed to analyze and interpret GBS datasets. As an ultimate MAS tool and a cost-effective technique, GBS has been successfully used in implementing genome-wide association study (GWAS), genomic diversity study, genetic linkage analysis, molecular marker discovery and genomic selection under a large scale of plant breeding programs.

Structural Determinants for the Binding of Morphinan Agonists to the μ-Opioid Receptor.

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Xiaojing Cong

Full Text Available Atomistic descriptions of the μ-opioid receptor (μOR noncovalently binding with two of its prototypical morphinan agonists, morphine (MOP and hydromorphone (HMP, are investigated using molecular dynamics (MD simulations. Subtle differences between the binding modes and hydration properties of MOP and HMP emerge from the calculations. Alchemical free energy perturbation calculations show qualitative agreement with in vitro experiments performed in this work: indeed, the binding free energy difference between MOP and HMP computed by forward and backward alchemical transformation is 1.2±1.1 and 0.8±0.8 kcal/mol, respectively, to be compared with 0.4±0.3 kcal/mol from experiment. Comparison with an MD simulation of μOR covalently bound with the antagonist β-funaltrexamine hints to agonist-induced conformational changes associated with an early event of the receptor's activation: a shift of the transmembrane helix 6 relative to the transmembrane helix 3 and a consequent loss of the key R165-T279 interhelical hydrogen bond. This finding is consistent with a previous proposal suggesting that the R165-T279 hydrogen bond between these two helices indicates an inactive receptor conformation.

Sexualidade de puérperas com bebês de risco La sexualidad de puérperas con bebés de riesgo Sexuality patterns of mothers with high-risk infants

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Leda Maria Belentani

2011-01-01

Full Text Available OBJETIVO: Identificar possíveis alterações na sexualidade de mulheres que experienciaram o puerpério com bebês de risco. MÉTODOS: Estudo do tipo coorte realizado com 193 puérperas que tiveram filhos nascidos entre maio e outubro de 2008 e incluídos no Programa de Vigilância ao Recém-nascido de Risco de Maringá-PR. Os dados foram coletados por meio de entrevista semi-struturada em duas visitas domiciliares, aos 45 dias e seis meses pós-parto. RESULTADOS: Entre as puérperas participantes 45,8% e 26,3% afirmaram que sua sexualidade estava pior do que antes da gravidez, respectivamente, aos 45 dias e seis meses após o parto. Não foi observada associação estatística entre sexualidade e qualquer variável aos 45 dias, mas o foi aos seis meses, após o parto em relação às intercorrências na gravidez (p=0,0259 e convívio com o companheiro (p=0,0093. CONCLUSÃO: Mães de recém-nascidos de risco, em especial, as que apresentaram intercorrência gestacional, necessitam de acompanhamento multidisciplinar e a longo prazoOBJETIVO: Identificar posibles alteraciones en la sexualidad de mujeres que experimentaron el puerperio con bebés de riesgo. MÉTODOS: Estudio de tipo cohorte realizado con 193 puérperas que tuvieron hijos nacidos entre mayo y octubre del 2008 e incluidos en el Programa de Vigilancia al Recién nacido de Riesgo de Maringá-PR. Los datos fueron recolectados por medio de una entrevista semi-estructurada en dos visitas domiciliarias, a los 45 días y seis meses post parto. RESULTADOS: Entre las puérperas participantes el 45,8% y el 26,3% afirmaron que su sexualidad estaba peor que antes del embarazo, a los 45 días y seis meses después del parto, respectivamente. No fue observada la asociación estadística entre sexualidad y cualquier variable a los 45 días, mas sí a los seis meses, después del parto en relación a las intercurrencias en el embarazo (p=0,0259 y convivencia con el compañero (p=0,0093. CONCLUSI�

"Okarte" reklāmas kampaņas "Onedēļa" komunikācija internetā 2013. gadā

OpenAIRE

Volonts, Kaspars

2013-01-01

Bakalaura darba tēma ir “"Okarte" reklāmas kampaņa "Onedēļa" komunikācija internetā 2013. gadā”. Tēma par zīmola komunikāciju interneta vidē ir aktuāla, jo interneta lietotāju skaits Latvijā aug katru gadu. Latvijā strādājošiem zīmoliem arvien biežāk jāsaskarās ar savu mērķauditoriju, izmantojot internetu. Bakalaura darba pētījuma mērķis ir izpētīt kā “Latvijas Mobilā Telefona” priekšapmaksas kartes “Okarte” zīmols komunicē savu tēlu un reklāmas kampaņu interneta vidē 2013.gadā. Ša...

Initial infection of roots and leaves reveals different resistance phenotypes associated with coat protein gene-mediated resistance to Potato mop-top virus.

Science.gov (United States)

Germundsson, Anna; Sandgren, Maria; Barker, Hugh; Savenkov, Eugene I; Valkonen, Jari P T

2002-05-01

Resistance to the pomovirus Potato mop-top virus (PMTV) was studied in potato (Solanum tuberosum cv. Saturna) and Nicotiana benthamiana transformed with the coat protein (CP) gene of PMTV. The incidence of PMTV infections was reduced in tubers of the CP-transgenic potatoes grown in the field in soil infested with the viruliferous vector, Spongospora subterranea. However, in those tubers that were infected, all three virus RNAs were detected and virus titres were high. The CP-transgenic N. benthamiana plants were inoculated with PMTV using two methods. Following mechanical inoculation of leaves, no RNA 3 (the CP-encoding RNA homologous to the transgene) was detected in leaves, but in some plants low amounts of RNA 3 were detected in roots; RNA 2 was readily detected in leaves and roots of several plants. Inoculation of roots using viruliferous S. subterranea resulted in infection of roots in all plants and the three PMTV RNAs were detected. However, no systemic movement of PMTV from roots to the above-ground parts was observed, indicating a novel expression of resistance. These data indicate that the CP gene-mediated resistance to PMTV specifically restricts accumulation of PMTV RNA 3, and is more effective in leaves than roots. Furthermore, expression of resistance is different depending on whether leaves or roots are inoculated. Data do not exclude the possibility that both a protein-mediated and an RNA-mediated resistance mechanism are involved.

27Al Magic Angle Spinning–Nuclear Magnetic Resonance (MAS-NMR) Analyses Applied to Historical Mortars

Czech Academy of Sciences Publication Activity Database

Hanzlíček, Tomáš; Perná, Ivana; Brus, Jiří

2013-01-01

Roč. 7, č. 2 (2013), s. 153-164 ISSN 1558-3058 R&D Projects: GA AV ČR IAA300460702 Institutional research plan: CEZ:AV0Z30460519; CEZ:AV0Z40500505 Keywords : mortars * magic angle spinning –nuclear magnetic resonance (MAS-NMR) in solid state * alumina-silicates Subject RIV: DM - Solid Waste and Recycling Impact factor: 0.714, year: 2013 http://www.tandfonline.com/doi/abs/10.1080/15583058.2011.624253

Active and passive fire protection system in academic building KH. Mas Mansur, Islamic University of Indonesia

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Suryoputro M. Ragil

2018-01-01

Full Text Available According to the theory of fire triangle, the existence of combustible materials, heat, and oxygen can cause fire disaster. KH. Mas Mansur building, Islamic University of Indonesia has a fire protection, but rarely to be checked regularly and the number of equipment is less standard as well as the lack of an evacuation route map to facilitate the evacuation process. Inside the building also does not provide safety signs such as the evacuation directions, exit, and warning in case of fire. Therefore, researchers analysed the infrastructure of prevention and control in the building KH. Mas Mansur. Researchers used the method of observation, interviews, and checklist to know the condition directly, and compare with the standard regulations. Results concordance rate of existing infrastructure is 67% fire extinguisher, hydrant box 56%, 71% alarms, sprinkler 0%, 40% detectors, emergency doors 71%, 50% emergency stairs, assembly point 0% and directions 0%. The current results were below the standard of at least 80%. As for recommendations, researchers create a new evacuation map then put the existing infrastructure according to standard regulations, and it had consulted with the specialist of Occupational Safety and Health in the field of fire.

Evaluación integral de la sensibilidad en los pies de las personas con diabetes mellitus tipo 2

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Valentina Rivas Acuña

2017-01-01

Full Text Available Introducción: Actualmente la diabetes mellitus tipo 2 es considerada una epidemia en el mundo, es uno de los problemas de mayor trascendencia, por su alta prevalencia como por su enorme repercusión social y económica, por tal motivo el propósito del estudio fue evaluar de manera integral la sensibilidad en los pies de las personas con diabetes mellitus tipo 2, de Villahermosa, Tabasco, México. Materiales y Métodos: El diseño fue descriptivo correlacional, la muestra fue de 198 personas. Se utilizó el Test del Michigan Neuropathy Screening con monofilamento de Semme Weinstein, Diapasón, temperatura frío/calor y reflejo Aquileo. Resultados y Discusión: El sexo femenino predominó con un 70.2% y el 29.8% hombres, el promedio de edad fue 56.44 años y 12.34 años promedio con la enfermedad. El 46% registró síntomas neuropáticos moderados, 26.3% graves; el 65.7% riesgo de neuropatía positiva (40.9% mujeres y 24.8% hombres, 41.1% con pérdida de sensibilidad moderada y 29.3% sensibilidad normal; el 74.7% tiene un control glucémico deficiente. Los factores de riesgo detectados con mayor prevalencia fueron helomas, hiperqueratosis y deformidades. Conclusiones: Existe una correlación significativa entre la pérdida de la sensibilidad con los años con la enfermedad, con la hiperglucemia y síntomas de neuropatía, la pérdida de sensibilidad en mujeres es de moderada a grave y en los hombres la pérdida de la sensibilidad es moderada. Cómo citar este artículo: Rivas V, Mateo Y, García H, Martínez A, Magaña M, Carrillo R.  Evaluación integral de la sensibilidad en los pies de las personas con diabetes mellitus tipo 2. Rev Cuid. 2017; 8(1:1423-32. http://dx.doi.org/10.15649/cuidarte.v8i1.348

Electromagnetic Scattering Analysis of Coated Conductors With Edges Using the Method of Auxiliary Sources (MAS) in Conjunction With the Standard Impedance Boundary Condition (SIBC)

DEFF Research Database (Denmark)

Anastassiu, H.T.; D.I.Kaklamani, H.T.; Economou, D.P.

2002-01-01

A novel combination of the method of auxiliary sources (MAS) and the standard impedance boundary condition (SIBC) is employed in the analysis of transverse magnetic (TM) plane wave scattering from infinite, coated, perfectly conducting cylinders with square cross sections. The scatterer is initia......A novel combination of the method of auxiliary sources (MAS) and the standard impedance boundary condition (SIBC) is employed in the analysis of transverse magnetic (TM) plane wave scattering from infinite, coated, perfectly conducting cylinders with square cross sections. The scatterer...

Use of 8-methoxypsoralen and long-wavelength ultraviolet radiation for decontamination of platelet concentrates

International Nuclear Information System (INIS)

Lin, L.; Wiesehahn, G.P.; Morel, P.A.; Corash, L.

1989-01-01

Transmission of viral diseases through blood products remains an unsolved problem in transfusion medicine. We have developed a psoralen photochemical system for decontamination of platelet concentrates in which platelets are treated with long wavelength ultraviolet radiation (UVA, 320-400 nm) in the presence of 8-methoxypsoralen (8-MOP). Bacteria, RNA viruses, and DNA viruses ranging in genome size from 1.2 x 10(6) daltons, encompassing the size range of human pathogens, were inoculated into platelet concentrates and subjected to treatment. This system inactivated 25 to 30 logs/h of bacteria Escherichia coli or Staphylococcus aureus, 6 logs/h of bacteriophage fd, 0.9 log/h of bacteriophage R17 and 1.1 logs/h of feline leukemia virus (FeLV) in platelet concentrates maintained in standard storage bags. Platelet integrity and in vitro function before, immediately following photochemical treatment, and during prolonged storage after treatment, were evaluated by measuring: (1) extracellular pH; (2) platelet yields; (3) extracellular lactate dehydrogenase (LDH) levels; (4) platelet morphology; (5) platelet aggregation responsiveness; (6) thromboxane beta-2 (TXB-2) production; (7) dense body secretion; and (8) alpha granule secretion. These assays demonstrated that this photochemical inactivation system inactivated bacteria and viruses in platelet concentrates with minimal adverse effects on the in vitro function of platelets in comparison to untreated control concentrates maintained under current, standard blood bank conditions

Use of 8-methoxypsoralen and long-wavelength ultraviolet radiation for decontamination of platelet concentrates

Energy Technology Data Exchange (ETDEWEB)

Lin, L.; Wiesehahn, G.P.; Morel, P.A.; Corash, L. (Diamond Scientific Company, Des Moines, IA (USA))

1989-07-01

Transmission of viral diseases through blood products remains an unsolved problem in transfusion medicine. We have developed a psoralen photochemical system for decontamination of platelet concentrates in which platelets are treated with long wavelength ultraviolet radiation (UVA, 320-400 nm) in the presence of 8-methoxypsoralen (8-MOP). Bacteria, RNA viruses, and DNA viruses ranging in genome size from 1.2 x 10(6) daltons, encompassing the size range of human pathogens, were inoculated into platelet concentrates and subjected to treatment. This system inactivated 25 to 30 logs/h of bacteria Escherichia coli or Staphylococcus aureus, 6 logs/h of bacteriophage fd, 0.9 log/h of bacteriophage R17 and 1.1 logs/h of feline leukemia virus (FeLV) in platelet concentrates maintained in standard storage bags. Platelet integrity and in vitro function before, immediately following photochemical treatment, and during prolonged storage after treatment, were evaluated by measuring: (1) extracellular pH; (2) platelet yields; (3) extracellular lactate dehydrogenase (LDH) levels; (4) platelet morphology; (5) platelet aggregation responsiveness; (6) thromboxane beta-2 (TXB-2) production; (7) dense body secretion; and (8) alpha granule secretion. These assays demonstrated that this photochemical inactivation system inactivated bacteria and viruses in platelet concentrates with minimal adverse effects on the in vitro function of platelets in comparison to untreated control concentrates maintained under current, standard blood bank conditions.

Antioxidant capacity of cornelian cherry (Cornus mas L.) - comparison between permanganate reducing antioxidant capacity and other antioxidant methods.

Science.gov (United States)

Popović, Boris M; Stajner, Dubravka; Slavko, Kevrešan; Sandra, Bijelić

2012-09-15

Ethanol extracts (80% in water) of 10 cornelian cherry (Cornus mas L.) genotypes were studied for antioxidant properties, using methods including DPPH(), ()NO, O(2)(-) and ()OH antiradical powers, FRAP, total phenolic and anthocyanin content (TPC and ACC) and also one relatively new, permanganate method (permanganate reducing antioxidant capacity-PRAC). Lipid peroxidation (LP) was also determined as an indicator of oxidative stress. The data from different procedures were compared and analysed by multivariate techniques (correlation matrix calculation and principal component analysis (PCA)). Significant positive correlations were obtained between TPC, ACC and DPPH(), ()NO, O(2)(-), and ()OH antiradical powers, and also between PRAC and TPC, ACC and FRAP. PCA found two major clusters of cornelian cherry, based on antiradical power, FRAP and PRAC and also on chemical composition. Chemometric evaluation showed close interdependence between PRAC method and FRAP and ACC. There was a huge variation between C. mas genotypes in terms of antioxidant activity. Copyright © 2012 Elsevier Ltd. All rights reserved.

Brain angiotensin-(1-7)/Mas axis: A new target to reduce the cardiovascular risk to emotional stress.

Science.gov (United States)

Fontes, Marco Antônio Peliky; Martins Lima, Augusto; Santos, Robson Augusto Souza dos

2016-04-01

Emotional stress is now considered a risk factor for several diseases including cardiac arrhythmias and hypertension. It is well known that the activation of neuroendocrine and autonomic mechanisms features the response to emotional stress. However, its link to cardiovascular diseases and the regulatory mechanisms involved remain to be further comprehended. The renin-angiotensin system (RAS) plays an important role in homeostasis on all body systems. Specifically in the brain, the RAS regulates a number of physiological aspects. Recent data indicate that the activation of angiotensin-converting enzyme/angiotensin II/AT1 receptor axis facilitates the emotional stress responses. On the other hand, growing evidence indicates that its counterregulatory axis, the angiotensin-converting enzyme 2 (ACE2)/(Ang)iotensin-(1-7)/Mas axis, reduces anxiety and attenuates the physiological responses to emotional stress. The present review focuses on angiotensin-(1-7)/Mas axis as a promising target to attenuate the physiological response to emotional stress reducing the risk of cardiovascular diseases. Copyright © 2015 Elsevier Ltd. All rights reserved.

Beneficios de la terapia con hidroxiúrea en niños con anemia de células falciformes = Benefits of hidroxyurea therapy in children with sickle cell disease

Directory of Open Access Journals (Sweden)

Donado Gómez, Jorge Hernando

2012-04-01

Full Text Available Objetivo: describir la toxicidad y los beneficios de la hidroxiúrea (HU en el tratamiento de niños con anemia de células falciformes (ACF.Materiales y métodos: estudio observacional descriptivo-retrospectivo de pacientes con ACF tratados con HU en el Hospital Pablo Tobón Uribe (HPTU de Medellín, Colombia, entre mayo de 2004 y septiembre de 2009. Se trató con este medicamento a 16 pacientes menores de 15 años, 11 de ellos (68,8% de sexo masculino. Todos los pacientes tenían anemia falciforme (Hb SS. Las variables se estudiaron antes y después del inicio de la HU. Resultados: se encontró una media de crisis dolorosas por ACF de 3,31 antes y 1,13 después de la HU (p = 0,006; la media de la necesidad de transfundir glóbulos rojos fue de 2,69 antes y 0,75 después (p = 0,112; los episodios de síndrome torácico agudo (STA tuvieron una media de 0,19 antes y 0,13 después (p = 0,705; la media de la necesidad de hospitalización por ACF fue de 1,94 antes y 1,06 después de la HU (p = 0,155. Un paciente (6,3% presentó toxicidad hematológica y dos (12,5% tuvieron toxicidad hepática, pero no hubo casos de toxicidad renal; tres pacientes (18,8% presentaron accidentes cerebrovasculares. No se encontraron neoplasias. Conclusión: la HU redujo significativamente la frecuencia de crisis dolorosas en los pacientes con ACF. La toxicidad fue en general aceptable. Se requieren estudios prospectivos, multicéntricos, doble ciego, controlados con placebo, para definir el papel de la HU en pacientes pediátricos.

Conditional Density Approximations with Mixtures of Polynomials

DEFF Research Database (Denmark)

Varando, Gherardo; López-Cruz, Pedro L.; Nielsen, Thomas Dyhre

2015-01-01

Mixtures of polynomials (MoPs) are a non-parametric density estimation technique especially designed for hybrid Bayesian networks with continuous and discrete variables. Algorithms to learn one- and multi-dimensional (marginal) MoPs from data have recently been proposed. In this paper we introduce...... two methods for learning MoP approximations of conditional densities from data. Both approaches are based on learning MoP approximations of the joint density and the marginal density of the conditioning variables, but they differ as to how the MoP approximation of the quotient of the two densities...

Tratamiento mediante dilatación con balón de un paciente con estenosis subaórtica por membrana: a propósito de un caso

Directory of Open Access Journals (Sweden)

Carlos Mariño

2013-10-01

Full Text Available La estenosis subaórtica es una lesión cardiaca poco frecuente, en el cual el tracto de salida del ventrículo izquierdo está estrechado por la presencia de un anillo fibroso o fibromuscular. Constituye 8 a 20% de todas las formas de obstrucción al tracto de salida del ventrículo izquierdo. La cirugía ha sido considerada el tratamiento de elección cuando el gradiente pico es mayor de 50 mmHg o en pacientes que, con gradientes menores, presentan progresión de la insuficiencia aórtica o dilatación de los diámetros ventriculares, disfunción ventricular o síntomas. Presentamos el caso de un paciente menor de edad, portador de estenosis subaórtica por membrana, con síntomas de insuficiencia cardiaca y función ventricular izquierda muy comprometida, en la que se realizó el tratamiento percutáneo, alternativo al quirúrgico, con resultado exitoso. Constituye el primer caso reportado en el país de tratamiento percutáneo con balón y con evolución favorable.

Photooxidative reactions of psoralens

International Nuclear Information System (INIS)

Potapenko, A.Ya.; Sukhorukov, V.L.

1984-01-01

The mechanism and biological significance of photooxidative reactions of psoralens are reviewed. Skin-photosensitizing activities of bifunctional and monofunctional psoralens are compared. Antioxidants tocopherols and butilated hydroxytoluene inhibit photochemical reactions of psoralens responsible for induction of erythema. The same antioxidants do not inhibit PUVA-therapy of psriasis. Though psoralens can generate singlet oxygen under UVA-irradiation (315 - 400 nm), nevertheless singlet oxygen does not play significant role in 8-methoxypsoralen (8-MOP) sensitized photooxidation of tocopherol or dihydroxyphenylalanine (DOPA). SH-compounds enhance the rate of 8-MOP sensitized photooxidation of DOPA by a factor of four, simultaneously the rate of oxidation of SH-groups is enhanced many fold in the presence of DOPA. Under UVA-irradiation in organic solvents psoralens are photooxidized. Dimeric photooxidized psoralens are easily destructed in water medium, their destruction induce oxidation of unsaturated lipids and DOPA. (author)

Interneta vietne "YouTube" kā reklāmas un infoizklaides kanāls 2008. gada pirmajā ceturksnī

OpenAIRE

Reinberga, Ieva

2008-01-01

Bakalaura darba mērķis ir izpētīt, kādus komunikācijas uzdevumus veikusi interneta vietne www.YouTube.com – reklāmas, izklaides, informācijas vai citus - laika periodā no 2008. gada 1. janvāra līdz 2008. gada 31. martam, konstatējot vietnes saturā reklāmai, izklaidei un informācijai raksturīgās iezīmes. Pētījums tiek balstīts uz reklāmas, infoklaides, interneta tehnoloģiju, spēles teorijas, populārās kultūras teorijām, kā arī, atsaucoties uz līdzšinējām analīzēm par vietnes YouTube vēstur...

MUNICIPAL ENVIRONMENTAL MANAGEMENT: A PROPOSAL OF INSTRUMENTS FOR DIAGNOSIS OF PUBLIC ENVIRONMENTAL POLICIES IN THE METROPOLITAN AREA OF SALVADOR (MAS

Directory of Open Access Journals (Sweden)

Tânia Cristina Azevedo

2016-04-01

Full Text Available The aim in this paper is to propose a model for mapping strategies of municipal environmental management for local environmental public policies. To do so, the study adopted a theoretical approach. More specifically, there is discussion on the concepts of public policies and the scenario of the Brazilian municipal environmental management, a brief history of the aspects that involve current national environmental policies. Methodologically, a bibliographical study was carried out through a literature review, which enabled the proposal of instruments for mapping actions and strategies of environmental management in the municipalities of the Metropolitan Area of Salvador (MAS. This theoretical study resulted in the creation of a model form that will be used by empirical researches for mapping the environmental public policies in the MAS City Halls.

New perspectives of 19F MAS NMR in the characterization of amorphous forms of atorvastatin in dosage formulations

Czech Academy of Sciences Publication Activity Database

Brus, Jiří; Urbanová, Martina; Šeděnková, Ivana; Brusová, H.

2011-01-01

Roč. 409, 1/2 (2011), s. 62-74 ISSN 0378-5173 R&D Projects: GA MŠk 2B08021 Institutional research plan: CEZ:AV0Z40500505 Keywords : 19F MAS NMR * factor analysis * polymorphism Subject RIV: CB - Analytical Chemistry, Separation Impact factor: 3.350, year: 2011

Aspectos Psicosociales Relacionados con el TEPT en Pacientes con Cáncer de Mama

OpenAIRE

Hernández Moreno, Fresia Paloma; Landero Hernández, René

2015-01-01

El objetivo del estudio fue analizar la relación del estrés, la depresión y las estrategias de afrontamiento con el Trastorno de Estrés Postraumático (TEPT) en una muestra de pacientes con cáncer de mama. Se realizó con una muestra no probabilística de 52 mujeres con cáncer de mama. Se encontró una relación entre TEPT y estrés (r= .344, p= .014), TEPT y depresión (rs=.346, p= .013). El TEPT correlacionó con evitación cognitiva (r= .437, p= .001), TEPT y desesperanza (rs= .437, p= .001) y TEPT...

KrasMAS: Implementation of a nuclear material computerized accounting system at the Mining and Chemical Combine through the Russian/US cooperative MPC and A program

International Nuclear Information System (INIS)

Dorofeev, K.V.; Zhidkov, V.V.; Martinez, B.J.; Perry, R.T.; Scott, S.C.

1998-01-01

The Russian/US Mining and Chemical Combine (Gorno-Kimichesky Kombinat, GKhK, also referred to as Krasnoyarsk-26) Material Protection, Control and Accounting (MPC and A) project was initiated in June 1996. A critical component of the ongoing cooperative MPC and A enhancements at the GKhK is the implementation of a computerized nuclear material control and accountability (MC and A) system. This system must meet the MC and A requirements of the GKhK by integrating the information generated by numerous existing and new MC and A components in place at the GKhK (e.g., scales, bar-code equipment, NDA measurement systems). During the first phase of this effort, the GKhK adapted CoreMAS (developed at Los Alamos National Laboratory) for use in the PuO 2 storage facility. This included formulation of Web-based user interfaces for plant personnel, Russification of the existing user interface, and at the functional level, modification of the CoreMAS stored procedures. The modified system is referred to as KrasMAS and builds upon completed work on CoreMAS. Ongoing efforts include adding GKhK specific report forms and expanding the functionality of the system for implementation at the radiochemical processing and reactor plants of the GKhK. Collaborations with other Russian facilities for appropriate parts of these efforts will be pursued

Radiation sensitizations at DNA-level by chemical and biological agents. Coordinated programme on improvement of radiotherapy of cancer using modifiers of radiosensitivity of cells

International Nuclear Information System (INIS)

Altmann, H.

1982-01-01

Radiation sensitization by chemical agents at DNA level is discussed. Procaine, Halothan and Metronidazole showed no significant effect on unscheduled DNA synthesis (UDS) in mouse spleen cells, investigated by autoradiography and no effect on rejoining of DNA single strand breaks after gamma or UV irradiation. Oxyphenbutazon and prednisolone reduced the replicative DNA synthesis in vitro and in vivo but there was only little effect on DNA repair in the in vivo experiments. These two substances showed also a small reduction in poly(ADP-ribose) synthesis (PAR synthesis). 5-methoxypsoralen (5-MOP) and 8-methoxypsoralen (8-MOP) in combination with UV irradiation showed that 5-MOP was more toxic than mutagen, but induced much less DNA crosslinks than 8-MOP. Autoradiographic studies of radiation sensitization by biological agents showed significant inhibition of UDS in Yoshida tumor cells after acute mycoplasma infection in rats. Nucleoid sedimentation studies showed only in the case of Yoshida tumor cells after mycoplasma infection a dramatic effect in the sedimentation behaviour. Sensitization of cells by changing chromatin structure was also studied. Benzamide, 3-NH 2 -benzamide, 3-Methoxybenzamide, Spermine, Theophyllin and Caffeine were tested in different concentrations on replicative DNA synthesis, UDS after UV irradiation and PAR synthesis Chinese hamster ovary cells. 5-Methoxybenzamide was the strongest sensitizer and inhibitor of the PAR synthesis, and was used in further experiments. Results of KFA Juelich on sensitization of a mamma-adenocarcinoma EO 771 on C57 B1 mice are given. Replicative DNA synthesis, DNA repair and PAR synthesis were compared in spleen cells and adenocarcinoma cells after treatment with 5-Methoxybenzamide. An inhibitory effect on UDS could be shown only in adenocarcinoma cells but not in the mice spleen cells

Relación del desarrollo cognitivo con el clima familiar y el estrés de la crianza Relationship of the cognitive development with the family clime and stress of the childrearing

Directory of Open Access Journals (Sweden)

José Ángel Vera Noriega

2005-12-01

Full Text Available Se llevo a cabo un estudio con 120 familias en pobreza extrema de las zonas marginales de Hermosillo, Sonora México. Madres de 32 años en promedio respondieron a una escala de funcionamiento familiar, estrés de la crianza y sus niños fueron medidos en desarrollo cognitivo. El objetivo fue evaluar las diferencias significativas entre los tres tipos de familias en su desarrollo cognitivo, el estrés de la crianza y el clima familiar. Se clasificaron las familias en base a la medida de clima familiar con un análisis de conglomerados (clusters. Los resultados indican: a tres tipos de climas, que etiquetamos como, disciplinado, cohesionado y sin orientación; b clima sin orientación se asocia a una percepción negativa del niño y de restricciones por la maternidad y presentan las medias mas bajas de desarrollo cognitivo; c el clima cohesivo se asocia con menos estrés en la madre por la crianza y los puntajes mas alto de desarrollo cognitivo.A study was performed over 120 families located in the marginal areas of Hermosillo, Sonora, Mexico. Mothers whose age averaged 32 years old responded to a scale of family performance and childrearing stress; their children were measured throughout cognitive development. This study was aimed to evaluate significant differences with regards to cognitive development, child-rearing stress and family environment among the three types of family. The families were classified based on a measurement of family environment with a cluster analysis. Consequently, the results indicate the following: a Three different types of environment, which were labeled as disciplined, in harmony and without direction; b the environment without direction becomes associated to a negative perception of the child and motherhood restrictions, resulting with the lowest average of cognitive development, thus; c the cohesive environment becomes associated with a lower level of stress in the mother induced by child-rearing and with the

Genotipi e mutanti del gene S del virus dell'epatite B (HBV in soggetti con infezione cronica

Directory of Open Access Journals (Sweden)

E. Tanzi

2003-05-01

Full Text Available

Il virus dell’epatite di tipo B (HBV presenta 7 genotipi (A-G, distinti in base alla sequenza genomica pre-S/S. Mutazioni in tale regione, in particolare nell’epitopo immunodominante dell’HBsAg (determinante a, permettono la selezione di “escape mutants” che sfuggono alla risposta immunitaria dell’ospite.

Obiettivi: indagare la distribuzione dei genotipi di HBV circolanti in Italia e valutare le possibili associazioni con i fattori di rischio; studiare la prevalenza delle varianti “escape” nell’ambito di una sorveglianza di tipo epidemiologico.

Metodi: in uno studio retrospettivo sono stati analizzati campioni di siero provenienti da 34 soggetti (27M, 7F; età media 42.2 anni, range 25-75 HBV/HIV-1co-infetti e da 24 pazienti (16M, 8F; età media 47.9 anni, range 24-82 con infezione cronica da HBV. I genotipi di HBV e le varianti virali sono state indagate mediante amplificazione, sequenziamento ed analisi filogenetica di un frammento di 1182 pb della regione pre-S/S. Risultati: la determinazione dei genotipi di HBV in 25/34 campioni da soggetti HBV/HIV+ ha evidenziato 12 genotipi D (48%, 8 A (32%, 4 G (16%, ed 1 B (4%; in 23/24 pazienti con infezione cronica da HBV sono stati riscontrati 13 D (56.5%, 7 A (30.4%, 2 F (8.7% ed 1 E (4.4%. Mutazioni nel determinante a sono risultate presenti in 8/25 (32% pazienti HIV/HBV+, di cui 3/8 (37.5% a livello del primo loop, 2/8 (25% del secondo, mentre in 3/8 casi (37.5% mutazioni erano presenti in entrambe le regioni.

Conclusioni: i genotipi più diffusi appaiono il D e l’A. Tra gli HIV/HBV+ il D sembra associato alla tossicodipendenza (80%. Degno di nota il riscontro di 4 soggetti con genotipo G (16% tra gli HIV/HBV+, prima segnalazione nel nostro Paese e di 3 soggetti (13% con genotipo F o E, non endemici in Italia. Mutazioni nel gene S sembrano correlare con il genotipo D e la tossicodipendenza.

The American Board of Emergency Medicine ConCert Examination: Emergency Physicians' Perceptions of Learning and Career Benefits.

Science.gov (United States)

Marco, Catherine A; Wahl, Robert P; Counselman, Francis L; Heller, Barry N; Harvey, Anne L; Joldersma, Kevin B; Kowalenko, Terry; Coombs, Andrea B; Reisdorff, Earl J

2016-09-01

As part of the American Board of Emergency Medicine (ABEM) Maintenance of Certification (MOC) program, ABEM-certified physicians are required to pass the Continuous Certification (ConCert) examination at least every 10 years. With the 2015 ConCert examination, ABEM sought to better understand emergency physicians' perceptions of the benefits of preparing for and taking the examination and the career benefits of staying ABEM-certified. This was a prospective survey study. A voluntary postexamination survey was administered at the end of the 2015 ABEM ConCert examination (September 21-26, 2015). Physicians were asked about the benefits of preparing for the examination and maintaining ABEM certification. Examination performance was compared to perceptions of learning and career benefits. Of the 2,601 on-time test takers, 2,511 respondents participated (96.5% participation rate). The majority of participants (92.0%) identified a benefit to preparing for the ConCert examination, which included reinforced medical knowledge (73.9%), increased knowledge (66.8%), and making them a better clinician (39.4%). The majority of respondents (90.8%) identified a career benefit of maintaining ABEM certification, which included more employment options (73.8%), more positively viewed by other physicians (56.8%), and better financial outcomes (29.8%). There was a statistically significant association between the perception of knowledge reinforcement and examination performance (p Medicine.

PEMANFAATAN TANAMAN ATRAKTAN MENGENDALIKAN HAMA KEONG MAS PADI

Directory of Open Access Journals (Sweden)

Ameilia Zuliyanti Siregar

2018-01-01

In Indonesia, many plantation as use as beneficial plants. This study aims to obtain an effective formula that can be used as a biopesticide to control snail pests during the vegetative phase from May to July 2017 using random non-factorial methods at two rice planting locations in the Village Lae parira, Dairi, North Sumatra. Design with 6 treatments and 3 replicates (ie control, neem leaves (Azadirachta indica, tobacco leaf (Nicotiana tabacum, sweet potato leaf (Manihot glaziovii, noni fruit, Morinda citrifolia, and betel nut (Areca catechu and papaya (Carica papaya as an eco-friendly herbaceous and biopesticide. Based on the study recorded in sampling for 7 days with 6 treatments had significant effect on the percentage affected by the clump of rice attacked and the percentage of death. Pearson correlation value recorded percentage of death and percentage of impacted  showed a very significant relationship. Neem is the best biopesticide in controlling mollusicides, followed by betel nuts, tobacco, poisonous yams and noni. Death of 100% snail mas will prevent damage to the clump of rice plants Dairi, North Sumatra. All biopesticide treatments were tested to control snail pests in rice plants that will increase agicultural productivity in maintaining food security in Dairi, North Sumatra.

Mobilā reklāma kā mobilo priekšapmaksas sarunu karšu reklāmas komunikācijas instruments: Y paaudzes radītās iespējas

OpenAIRE

Daudze, Anita

2009-01-01

Bakalaura darba temats ir „Mobilā reklāma kā mobilo priekšapmaksas sarunu karšu reklāmas komunikācijas instruments: Y paaudzes radītās iespējas”. Pētījuma problēma ir mobilās reklāmas piemērotība komunikācijai ar Y paaudzes pārstāvjiem – mobilo priekšapmaksas sarunu karšu lietotājiem. Darba teorētiskais pamatojums balstīts uz Y paaudzes jēdziena izpratni, mobilā telefona kā reklāmas komunikācijas kanāla aplūkošanu, kā arī mobilā mārketinga un reklāmas pamatprincipu izklāstu. Darbā izman...

76 FR 6179 - Eighth Meeting: RTCA Special Committee 223: Airport Surface Wireless Communications

Science.gov (United States)

2011-02-03

... Review the EUROCAE WG-82 straw man MOPS proposal Discuss MOPS content detail versus referencing other AeroMACS Specs Review RTCA MOPS Drafting Guide and make Work Assignments Wednesday Afternoon--Reconvene...

La depleción de las células T regulatorias aumenta el número de las células CD8 durante la infección con el virus del tumor mamario murino Regulatory T cell depletion increases the number of CD8 cells during mouse mammary tumor virus infection

Directory of Open Access Journals (Sweden)

Gabriel Cabrera

2011-06-01

Full Text Available El virus del tumor mamario murino (MMTV es un retrovirus que se transmite durante la lactancia y que ha desarrollado estrategias para explotar y subvertir el sistema inmune. En un modelo de infección natural con MMTV hemos mostrado previamente que la infección causa incrementos tempranos y progresivos de células T regulatorias (Treg CD4+CD25+Foxp3+ específicas para el superantígeno (Sag viral en las placas de Peyer (PP. En este trabajo se evaluó si la depleción de las células Treg influencia la población de células CD8+ durante la infección con MMTV a través del amamantamiento. La depleción de las células Treg al día 6 de infección causó incrementos en el porcentaje y número absoluto de las células CD8+ en los ganglios y provocó un incremento en la intensidad de fluorescencia media del marcador de activación CD44 en esas células. Los incrementos en el número absoluto de las células CD8 se observaron en células con cadenas variables Vβ del receptor de las células T (TCR tanto reactivas como no reactivas al Sag. Previamente habíamos demostrado que la depleción de las células Treg al día 6 de infección disminuye la carga viral. Los resultados presentados en este trabajo sugieren que, al menos a partir del día 6 de infección con MMTV, las células Treg podrían tener un rol inhibiendo la generación de una respuesta CD8 antiviral.Mouse mammary tumor virus (MMTV is a milk-borne betaretrovirus that has developed strategies to exploit and subvert the host immune system. We have shown in a natural model of MMTV infection that the virus causes early and progressive increases in superantigen (Sag-specific CD4+ CD25+ Foxp3+ regulatory T cells (Treg in Peyer's patches. Herein, we evaluated whether the depletion of Treg cells affects the CD8+ population during milk-borne MMTV infection. At day 6 of infection, the depletion of Treg cells increased the percentage and absolute number of CD8+ cells in lymph nodes as well as the

Eficacia del hierro aminoquelado en comparación con el sulfato ferroso como fortificante de un complemento alimentario en preescolares con deficiencia de hierro, Medellín, 2011

Directory of Open Access Journals (Sweden)

Maylen Liseth Rojas

2013-09-01

Full Text Available Introducción. La disminución de los depósitos de hierro constituye el primer eslabón de la cadena conducente a la deficiencia de hierro, la carencia nutricional más prevalente y principal causa de anemia en todo el mundo, situación que puede prevenirse mediante la fortificación de alimentos. Objetivo. Comparar la eficacia del hierro aminoquelado con el sulfato ferroso como fortificante de un complemento alimentario en preescolares con deficiencia de hierro. Materiales y métodos. Se llevó a cabo un ensayo clínico triple ciego con distribución aleatoria de grupos. Se analizaron 56 preescolares con deficiencia de hierro (ferritina menor de 24 ng/ml a los que se les dio diariamente 13 g de leche con 12,5 mg de hierro. Después de dos meses se midieron los niveles de hemoglobina, hematocrito y ferritina sérica. Resultados. En el grupo con sulfato ferroso la concentración de ferritina sérica aumentó de 18,8 a 24,1ng/ml, mientras que dicha variación fue de 18,4 a 29,7 ng/ml con el hierro aminoquelado, en ambos casos con diferencias significativas. El nivel de ferritina final difirió según el grupo de estudio, siendo mayor en el grupo con hierro aminoquelado (p=0,022. La hemoglobina y el hematocrito no variaron después de la intervención. Las reacciones adversas en el grupo con sulfato ferroso fueron de 35,7 %, en contraste con el 42,9 % en el grupo con hierro aminoquelado; cinco niños presentaron infección delas vías respiratorias, sin diferencias estadísticas. Conclusiones. Los dos compuestos aumentan los niveles de ferritina, siendo mayor el aumento entre quienes toman leche con hierro aminoquelado. No fue diferente la incidencia de reacciones adversas o de infecciones entre los grupos. Identificador en Clinicaltrials.gov: NCT01412723 doi: http://dx.doi.org/10.7705/biomedica.v33i3.775

Analisis del signo de Hoover en relacion con parametros funcionales, radiologicos y de radio de curvatura en pacientes con enfermedad pulmonar obstructiva cronica

Directory of Open Access Journals (Sweden)

M. E. Capria

2003-10-01

Full Text Available El propósito del presente trabajo fue: 1 relacionar el signo de Hoover SH (+ con diversos parámetros funcionales (espirometría y volúmenes pulmonares y radiológicos (radiografías posteroan-teriores, 2 caracterizar los cambios en el radio de curvatura y la eficiencia del diafragma, y restablecer relaciones con los parámetros funcionales y radiológicos. Se estudiaron 15 pacientes con EPOC (SH (+, n: 8. El radio de curvatura fue determinado en el hemidiafragma derecho en inspiración y espiración máximas. Los SH(+ se hallaron más severamente obstruidos (VEF1%, p 0.005% y con mayor atrapamiento aéreo (VR/CPT %, p 0.01. El radio espiratorio (Re fue mayor (p 0.05, y su eficiencia (1/Re, fue menor (p 0.05. El VEF1% correlacionó con el grado de hiperinflación según CPT % (r -0.58, p 0.022 y con el atrapamiento aéreo según VR% (r -0.77, p 0.0008. Los pacientes con menor VEF1% presentaron un Re mayor (r -0. 61, p 0.015 y menor eficiencia diafragmática en espiración (1/Re de acuerdo a: 1/Re = 0.093 cm-1 + 0.0012 cm-1 * VEF1% (r 0.688, p 0.0054. El VEF1 correlacionó con la movilidad diafragmática (r 0.71, p 0.003. La PaCO2 correlacionó con la CPT % (r 0.534, p 0.04, con el VR % (r 0.62, p 0.014 y con los parámetros radiológicos de hiperinflación (r 0.546, p 0.035 y atrapamiento aéreo (r 0.528, p 0.043. El SH(+ sugiere obstrucción bronquial severa, aplanamiento del diafragma, consiguiente aumento del radio de curvatura, menor movilidad y menor eficiencia.The purpose of the present study was: 1 to relate the Hoover sign -SH (+- with several functional (spirometry and lung volumes and radiographic (AP x-ray parameters, 2 to characterize the changes in diaphragmatic curvature radius and the efficiency and to establish some relationships with the functional and radiographic parameters. Fifteen patients with COPD (SH (+, n: 8 were studied. The radius was determined in the right hemidiaphragm after maximal inspired and expired x-ray. The

Reconstrucción de lesiones osteocondrales con fibra de carbono

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Carranza Bencano, A.; Armas-Padrón, J. R.; Lozano, Mª A.

1998-01-01

Objetivo: Estudiar a largo plazo la evolución histológica de defectos osteocondrales de la rótula de conejos tratados con fibra de carbono. Material y Método: 18 conejos de raza gigante español, variedad parda, de ambos sexos, con un peso aproximado de 1.5 a 2 Kg y 18 discos Cleveland de fibra de carbono de 8 mm de diámetro (Medicarb®, fabricado por Leyland Medical International). Creación de un defecto de 6 mm. de diámetro en la superficie articular de la rótula, hasta alcanzar el teji...

Reabsorción radicular inflamatoria en sujetos con tratamiento ortodóntico. Cartagena (Colombia

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Farith González Martínez

2012-01-01

Full Text Available Objetivo: Determinar la ocurrencia de Reabsorción Radicular Inflamatoria en sujetos sometidos a movimiento dental con cuatro técnicas de ortodoncia. Materiales y métodos: Estudio de cohorte con seguimiento a un año, evaluando la reabsorción radicular inflamatoria con cuatro técnicas de ortodoncia, a partir de la escala de Levander and Malmgren. Las mediciones se realizaron en 176 dientes, usando tres radiografías periapicales por participante cada tres meses. Los datos fueron analizados a través de proporciones de incidencia. El Riesgo Relativo se utilizó para la asociación entre la presencia de reabsorción y la técnica de ortodoncia, con intervalos de confianza del 95 %. Para la significancia estadística se aplicaron los test de Kruskal Wallis, Mc-Nemar y Fischer. Se realizó un análisis multivariable por regresión logística. Resultados: La incidencia de Reabsorción Radicular fue del 68,2 %, presentándose a los nueve y doce meses. Se observaron cambios radiculares con grado 1 en 8,5 % de los dientes y grado 2 con 2,8 %, siendo laterales los de mayor proporción (6,3%. En los dientes sometidos a la técnica de Arco de canto se encontró un riesgo 3,3 veces mayor en comparación con las técnicas pre-ajustadas. Conclusiones: Existe Reabsorción Radicular en los dientes sometidos a movimiento dental durante el tratamiento de ortodoncia, sin embargo, estos cambios se consideran leves y dependen de la biomecánica utilizada en cada técnica.

Daño nuclear en neuronas de cerebros de pacientes con enfermedad de Alzheimer y otras demencias

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Francisco Lopera

2000-02-01

Full Text Available

8pt; font-family: Arial">Introducción: 8pt; font-family: Arial">La enfermedad de Alzheimer (EA es una entidad neurodegenerativa y es la causa más común de demencia. Recientemente se reportó en Antioquia (Colombia un grupo familiar con una mutación puntual en el codon 280 de la Presenilina 1 denominada E280A (sustitución de un ácido glutámico por una alanina, la cual produce un incremento en el acúmulo de 8pt; font-family: Symbol">b8pt; font-family: Arial">-Amiloide (8pt; font-family: Symbol">b8pt; font-family: Arial">A de 42-43 aminoácidos y una patología cerebral severa. Durante los últimos años se ha propuesto que la muerte celular es uno de los factores principales de pérdida neuronal en la EA. Hasta el presente no se ha establecido el tipo de muerte celular implicadas en la pérdida neuronal. Por lo tanto el objetivo de esta investigación es establecer el tipo de muerte celular que ocurre en la EA y otras demencias tales como la Demencia Fronto Temporal (DFT, Huntington y Demencia Cerebro Vascular, con base en los siguientes criterios: 1. Fragmentación del ADN. 2. Cambios morfológicos nucleares. 3. Cambios citoplasmáticos y 4. Expresión de ciertas proteínas asociadas a muerte celular. Los resultados de esta investigación permitirán establecer una correlación entre los parámetros morfológicos e histoquímicos antes mencionados, entre placas de 8pt; font-family: Symbol">b8pt; font-family: Arial">A y ovillos neurofibrilares en la EA y con ovillos neurofibrilares en la DFT adicionalmente. Este trabajo nos permitirá determinar si existe un mecanismo común de muerte celular en las enfermedades neurodegenerativas con demencia.

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