WorldWideScience

Sample records for computer-aided lead optimization

  1. Computer-Aided Parallelizer and Optimizer

    Science.gov (United States)

    Jin, Haoqiang

    2011-01-01

    The Computer-Aided Parallelizer and Optimizer (CAPO) automates the insertion of compiler directives (see figure) to facilitate parallel processing on Shared Memory Parallel (SMP) machines. While CAPO currently is integrated seamlessly into CAPTools (developed at the University of Greenwich, now marketed as ParaWise), CAPO was independently developed at Ames Research Center as one of the components for the Legacy Code Modernization (LCM) project. The current version takes serial FORTRAN programs, performs interprocedural data dependence analysis, and generates OpenMP directives. Due to the widely supported OpenMP standard, the generated OpenMP codes have the potential to run on a wide range of SMP machines. CAPO relies on accurate interprocedural data dependence information currently provided by CAPTools. Compiler directives are generated through identification of parallel loops in the outermost level, construction of parallel regions around parallel loops and optimization of parallel regions, and insertion of directives with automatic identification of private, reduction, induction, and shared variables. Attempts also have been made to identify potential pipeline parallelism (implemented with point-to-point synchronization). Although directives are generated automatically, user interaction with the tool is still important for producing good parallel codes. A comprehensive graphical user interface is included for users to interact with the parallelization process.

  2. Computer-aided lead optimization: improved small-molecule inhibitor of the zinc endopeptidase of botulinum neurotoxin serotype A.

    Directory of Open Access Journals (Sweden)

    Jing Tang

    Full Text Available Optimization of a serotype-selective, small-molecule inhibitor of botulinum neurotoxin serotype A (BoNTA endopeptidase is a formidable challenge because the enzyme-substrate interface is unusually large and the endopeptidase itself is a large, zinc-binding protein with a complex fold that is difficult to simulate computationally. We conducted multiple molecular dynamics simulations of the endopeptidase in complex with a previously described inhibitor (K(i (app of 7+/-2.4 microM using the cationic dummy atom approach. Based on our computational results, we hypothesized that introducing a hydroxyl group to the inhibitor could improve its potency. Synthesis and testing of the hydroxyl-containing analog as a BoNTA endopeptidase inhibitor showed a twofold improvement in inhibitory potency (K(i (app of 3.8+/-0.8 microM with a relatively small increase in molecular weight (16 Da. The results offer an improved template for further optimization of BoNTA endopeptidase inhibitors and demonstrate the effectiveness of the cationic dummy atom approach in the design and optimization of zinc protease inhibitors.

  3. Performative Computation-aided Design Optimization

    Directory of Open Access Journals (Sweden)

    Ming Tang

    2012-12-01

    Full Text Available This article discusses a collaborative research and teaching project between the University of Cincinnati, Perkins+Will’s Tech Lab, and the University of North Carolina Greensboro. The primary investigation focuses on the simulation, optimization, and generation of architectural designs using performance-based computational design approaches. The projects examine various design methods, including relationships between building form, performance and the use of proprietary software tools for parametric design.

  4. Computer-Aided Communication Satellite System Analysis and Optimization.

    Science.gov (United States)

    Stagl, Thomas W.; And Others

    Various published computer programs for fixed/broadcast communication satellite system synthesis and optimization are discussed. The rationale for selecting General Dynamics/Convair's Satellite Telecommunication Analysis and Modeling Program (STAMP) in modified form to aid in the system costing and sensitivity analysis work in the Program on…

  5. Optimization of a Breast Mass Classifier for Computer-Aided Ultrasound Analysis

    Science.gov (United States)

    Andrè, M. P.; Galperin, M.; Contro, G.; Omid, N.; Olson, L.

    The goal of this research was to optimize performance of a Computer-Aided Diagnostic system to identify, analyze and compare breast masses based on parameters measured in the ultrasound image. We compared case-based reasoning using Relative Similarity to an Artificial Neural Network in order to implement an objective form of the ACR BIRADS scheme to describe and score breast masses. The image feature set was reduced to nine including margins, shape, echogenicity, echo texture, orientation and posterior acoustic attenuation. Both classifiers performed well with a high ROC AZ although RS performed significantly better than the ANN in Specificity, PPV and achieved the goal of very high Specificity without a reduction in Sensitivity. Compared to a preliminary version of the RS classifier this optimized version of RS has significantly higher AZ (0.96 vs. 0.93)

  6. Designing optimal transportation networks: a knowledge-based computer-aided multicriteria approach

    Energy Technology Data Exchange (ETDEWEB)

    Tung, S.I.

    1986-01-01

    The dissertation investigates the applicability of using knowledge-based expert systems (KBES) approach to solve the single-mode (automobile), fixed-demand, discrete, multicriteria, equilibrium transportation-network-design problem. Previous works on this problem has found that mathematical programming method perform well on small networks with only one objective. Needed is a solution technique that can be used on large networks having multiple, conflicting criteria with different relative importance weights. The KBES approach developed in this dissertation represents a new way to solve network design problems. The development of an expert system involves three major tasks: knowledge acquisition, knowledge representation, and testing. For knowledge acquisition, a computer aided network design/evaluation model (UFOS) was developed to explore the design space. This study is limited to the problem of designing an optimal transportation network by adding and deleting capacity increments to/from any link in the network. Three weighted criteria were adopted for use in evaluating each design alternative: cost, average V/C ratio, and average travel time.

  7. Testing of New Materials and Computer Aided Optimization of Process Parameters and Clamping Device During Predevelopment of Laser Welding Processes

    Science.gov (United States)

    Weidinger, Peter; Günther, Kay; Fitzel, Martin; Logvinov, Ruslan; Ilin, Alexander; Ploshikhin, Vasily; Hugger, Florian; Mann, Vincent; Roth, Stephan; Schmidt, Michael

    The necessity for weight reduction in motor vehicles in order to save fuel consumption pushes automotive suppliers to use materials of higher strength. Due to their excellent crash behavior high strength steels are increasingly applied in various structures. In this paper some predevelopment steps for a material change from a micro alloyed to dual phase and complex phase steels of a T-joint assembly are displayed. Initially the general weldability of the materials regarding pore formation, hardening in the heat affected zone and hot cracking susceptibility is discussed. After this basic investigation, the computer aided design optimization of a clamping device is shown, in which influences of the clamping jaw, the welding position and the clamping forces upon weld quality are presented. Finally experimental results of the welding process are displayed, which validate the numerical simulation.

  8. Computer aided drug design

    Science.gov (United States)

    Jain, A.

    2017-08-01

    Computer based method can help in discovery of leads and can potentially eliminate chemical synthesis and screening of many irrelevant compounds, and in this way, it save time as well as cost. Molecular modeling systems are powerful tools for building, visualizing, analyzing and storing models of complex molecular structure that can help to interpretate structure activity relationship. The use of various techniques of molecular mechanics and dynamics and software in Computer aided drug design along with statistics analysis is powerful tool for the medicinal chemistry to synthesis therapeutic and effective drugs with minimum side effect.

  9. Upon the Modeling and the Optimization of the Debiting Process through Computer Aided Non-Conventional Technologies

    Directory of Open Access Journals (Sweden)

    Tiberiu Marius Karnyanszky

    2009-01-01

    Full Text Available he debiting process of the remarkable properties materials can be managed through unconventional technologies as the complex electrical erosion. This paper presents the mathematical modeling and simulation of a particular processing to establish the shortest cutting time and the better surface quality based on the best combination of input parameters. This paper presents the modeling of the previous experimental results to obtain a mathematical dependence of the output parameters (processing time, surface quality on the input parameters (voltage or current. All the experimental data are memorized on a database and for each particular debiting process a new dependence is built. The previous results database is built using personal experiments and results presented in references. These results were obtained using a research scheduler and a computer-based application organizes these results into a database separated on different mechanical processes, work conditions, materials, devices. All the experiments applied in the Romanian laboratories or practical applications of the nonconventional technological processes in the factories were based on the particular conditions of one activity. This papers presents the technical implementation of a computer-aided solution that keeps all previous experimental data, optimizes the processing conditions and eventual manage the driving gear. The flow-chart we present in this paper offers a solution for practitioners to reduce the electrical consumption while a technological processing of special materials is necessary. The computer program and the database can be easily adapted to any technological processes (conventional or not. No general available mathematical formulas for the dependency of the output parameters on the input ones are yet presented. The software we developed uses interpolation to determine the best polynomial or exponential equation and offers the combination of input values to minimize the

  10. A new decomposition-based computer-aided molecular/mixture design methodology for the design of optimal solvents and solvent mixtures

    DEFF Research Database (Denmark)

    Karunanithi, A.T.; Achenie, L.E.K.; Gani, Rafiqul

    2005-01-01

    This paper presents a novel computer-aided molecular/mixture design (CAMD) methodology for the design of optimal solvents and solvent mixtures. The molecular/mixture design problem is formulated as a mixed integer nonlinear programming (MINLP) model in which a performance objective...... is to be optimized subject to structural, property, and process constraints. The general molecular/mixture design problem is divided into two parts. For optimal single-compound design, the first part is solved. For mixture design, the single-compound design is first carried out to identify candidates...... the design of an optimal extractant for the separation of acetic acid from water by liquid-liquid extraction. The results suggest that the new extractant would be able to perform better than the extractant being widely used for this separation. The second case study is an industrial problem involving...

  11. A new decomposition-based computer-aided molecular/mixture design methodology for the design of optimal solvents and solvent mixtures

    DEFF Research Database (Denmark)

    Karunanithi, A.T.; Achenie, L.E.K.; Gani, Rafiqul

    2005-01-01

    and then the second part is solved to determine the optimal mixture. The decomposition of the CAMD MINLP model into relatively easy to solve subproblems is essentially a partitioning of the constraints from the original set. This approach is illustrated through two case studies. The first case study involves...... the design of an optimal extractant for the separation of acetic acid from water by liquid-liquid extraction. The results suggest that the new extractant would be able to perform better than the extractant being widely used for this separation. The second case study is an industrial problem involving......This paper presents a novel computer-aided molecular/mixture design (CAMD) methodology for the design of optimal solvents and solvent mixtures. The molecular/mixture design problem is formulated as a mixed integer nonlinear programming (MINLP) model in which a performance objective...

  12. Computer aided control engineering

    DEFF Research Database (Denmark)

    Szymkat, Maciej; Ravn, Ole

    1997-01-01

    Current developments in the field of Computer Aided Control Engineering (CACE) have a visible impact on the design methodologies and the structure of the software tools supporting them. Today control engineers has at their disposal libraries, packages or programming environments that may be speci......Current developments in the field of Computer Aided Control Engineering (CACE) have a visible impact on the design methodologies and the structure of the software tools supporting them. Today control engineers has at their disposal libraries, packages or programming environments that may...

  13. Computer Aided Lecturing.

    Science.gov (United States)

    Van Meter, Donald E.

    1994-01-01

    Surveyed students taking a natural resource conservation course to determine the effects of computer software that provides tools for creating and managing visual presentations to students. Results indicated that 94% of the respondents believed computer-aided lectures helped them and recommended their continued use; note taking was more effective,…

  14. Computer aided product design

    DEFF Research Database (Denmark)

    Constantinou, Leonidas; Bagherpour, Khosrow; Gani, Rafiqul

    1996-01-01

    A general methodology for Computer Aided Product Design (CAPD) with specified property constraints which is capable of solving a large range of problems is presented. The methodology employs the group contribution approach, generates acyclic, cyclic and aromatic compounds of various degrees......-liquid equilibria (LLE), solid-liquid equilibria (SLE) and gas solubility. Finally, a computer program based on the extended methodology has been developed and the results from five case studies highlighting various features of the methodology are presented....

  15. Computer aided control engineering

    DEFF Research Database (Denmark)

    Szymkat, Maciej; Ravn, Ole

    1997-01-01

    levels.The major conclusions of the paper are related with identifying the factors affecting the software tool integration in a way needed to facilitate design "inter-phase" communication. These are: standard application interfaces, dynamic data exchange mechanisms, code generation techniques and general......Current developments in the field of Computer Aided Control Engineering (CACE) have a visible impact on the design methodologies and the structure of the software tools supporting them. Today control engineers has at their disposal libraries, packages or programming environments that may...

  16. Computer Aided Learning of Mathematics: Software Evaluation

    Science.gov (United States)

    Yushau, B.; Bokhari, M. A.; Wessels, D. C. J.

    2004-01-01

    Computer Aided Learning of Mathematics (CALM) has been in use for some time in the Prep-Year Mathematics Program at King Fahd University of Petroleum & Minerals. Different kinds of software (both locally designed and imported) have been used in the quest of optimizing the recitation/problem session hour of the mathematics classes. This paper…

  17. Optimization leads to symmetry

    Institute of Scientific and Technical Information of China (English)

    Chenghong WANG; Yuqian GUO; Daizhan CHENG

    2004-01-01

    The science of complexity studies the behavior and properties of complex systems in nature and human society.Particular interest has been put on their certain simple common properties.Symmetry is one of such properties.Symmetric phenomena can be found in many complex systems.The purpose of this paper is to reveal the internal reason of the symmetry.Using some physical systems and geometric objects,the paper shows that many symmetries are caused by optimization under certain criteria.It has also been revealed that an evolutional process may lead to symmetry.

  18. Computer-aided design–computer-aided engineering associative feature-based heterogeneous object modeling

    Directory of Open Access Journals (Sweden)

    Jikai Liu

    2015-12-01

    Full Text Available Conventionally, heterogeneous object modeling methods paid limited attention to the concurrent modeling of geometry design and material composition distribution. Procedural method was normally employed to generate the geometry first and then determine the heterogeneous material distribution, which ignores the mutual influence. Additionally, limited capability has been established about irregular material composition distribution modeling with strong local discontinuities. This article overcomes these limitations by developing the computer-aided design–computer-aided engineering associative feature-based heterogeneous object modeling method. Level set functions are applied to model the geometry within computer-aided design module, which enables complex geometry modeling. Finite element mesh is applied to store the local material compositions within computer-aided engineering module, which allows any local discontinuities. Then, the associative feature concept builds the correspondence relationship between these modules. Additionally, the level set geometry and material optimization method are developed to concurrently generate the geometry and material information which fills the contents of the computer-aided design–computer-aided engineering associative feature model. Micro-geometry is investigated as well, instead of only the local material composition. A few cases are studied to prove the effectiveness of this new heterogeneous object modeling method.

  19. Optimization of Network Topology in Computer-Aided Detection Schemes Using Phased Searching with NEAT in a Time-Scaled Framework.

    Science.gov (United States)

    Tan, Maxine; Pu, Jiantao; Zheng, Bin

    2014-01-01

    In the field of computer-aided mammographic mass detection, many different features and classifiers have been tested. Frequently, the relevant features and optimal topology for the artificial neural network (ANN)-based approaches at the classification stage are unknown, and thus determined by trial-and-error experiments. In this study, we analyzed a classifier that evolves ANNs using genetic algorithms (GAs), which combines feature selection with the learning task. The classifier named "Phased Searching with NEAT in a Time-Scaled Framework" was analyzed using a dataset with 800 malignant and 800 normal tissue regions in a 10-fold cross-validation framework. The classification performance measured by the area under a receiver operating characteristic (ROC) curve was 0.856 ± 0.029. The result was also compared with four other well-established classifiers that include fixed-topology ANNs, support vector machines (SVMs), linear discriminant analysis (LDA), and bagged decision trees. The results show that Phased Searching outperformed the LDA and bagged decision tree classifiers, and was only significantly outperformed by SVM. Furthermore, the Phased Searching method required fewer features and discarded superfluous structure or topology, thus incurring a lower feature computational and training and validation time requirement. Analyses performed on the network complexities evolved by Phased Searching indicate that it can evolve optimal network topologies based on its complexification and simplification parameter selection process. From the results, the study also concluded that the three classifiers - SVM, fixed-topology ANN, and Phased Searching with NeuroEvolution of Augmenting Topologies (NEAT) in a Time-Scaled Framework - are performing comparably well in our mammographic mass detection scheme.

  20. Computer aided surface representation

    Energy Technology Data Exchange (ETDEWEB)

    Barnhill, R.E.

    1989-02-09

    The central research problem of this project is the effective representation and display of surfaces, interpolating to given information, in three or more dimensions. In a typical problem, we wish to create a surface from some discrete information. If this information is itself on another surface, the problem is to determine a surface defined on a surface,'' which is discussed below. Often, properties of an already constructed surface are desired: such geometry processing'' is described below. The Summary of Proposed Research from our original proposal describes the aims of this research project. This Summary and the Table of Contents from the original proposal are enclosed as an Appendix to this Progress Report. The broad sweep from constructive mathematics through algorithms and computer graphics displays is utilized in the research. The wide range of activity, directed in both theory and applications, makes this project unique. Last month in the first Ardent Titan delivered in the State of Arizona came to our group, funded by the DOE and Arizona State University. Although the Titan is a commercial product, its newness requires our close collaboration with Ardent to maximize results. During the past year, four faculty members and several graduate research assistants have worked on this DOE project. The gaining of new professionals is an important aspect of this project. A listing of the students and their topics is given in the Appendix. The most significant publication during the past year is the book, Curves and Surfaces for Computer Aided Geometric Design, by Dr. Gerald Farin. This 300 page volume helps fill a considerable gap in the subject and includes many new results on Bernstein-Bezier curves and surfaces.

  1. COMPUTER-AIDED DRUG DISCOVERY AND DEVELOPMENT (CADDD): in silico-chemico-biological approach

    OpenAIRE

    Kapetanovic, I.M.

    2006-01-01

    It is generally recognized that drug discovery and development are very time and resources consuming processes. There is an ever growing effort to apply computational power to the combined chemical and biological space in order to streamline drug discovery, design, development and optimization. In biomedical arena, computer-aided or in silico design is being utilized to expedite and facilitate hit identification, hit-to-lead selection, optimize the absorption, distribution, metabolism, excret...

  2. Computer-Aided Modeling Framework

    DEFF Research Database (Denmark)

    Fedorova, Marina; Sin, Gürkan; Gani, Rafiqul

    development and application. The proposed work is a part of the project for development of methods and tools that will allow systematic generation, analysis and solution of models for various objectives. It will use the computer-aided modeling framework that is based on a modeling methodology, which combines....... In this contribution, the concept of template-based modeling is presented and application is highlighted for the specific case of catalytic membrane fixed bed models. The modeling template is integrated in a generic computer-aided modeling framework. Furthermore, modeling templates enable the idea of model reuse...... are generated through the template in ICAS-MoT and translated into a model object. Once in ICAS-MoT, the model is numerical analyzed, solved and identified. A computer-aided modeling framework integrating systematic model derivation and development tools has been developed. It includes features for model...

  3. Computer Aided Filter Design.

    Science.gov (United States)

    1987-12-01

    FIR filter can be described in the following. [Ref. 2] 1. FIR filters with exact linear phase can be easily designed. Linear phase filters are important...response for the four cases of linear phase filter , i.e., even or odd symmetry with an even or odd number of terms, can be written in the form: H (eJ ) = e...Ansari, The Design and Application of Optimal FIR Fractional Phase Filters , IEEE on Acoutics, Speech and Signal Processing, Vol. 2, 1987, pp.896-899. 77 14

  4. Computer-aided design of conveyor belts

    Energy Technology Data Exchange (ETDEWEB)

    Karolewski, B.; Pytel, J.

    1984-01-01

    Possibilities are discussed for using mathematical models of belt conveyors for development of computer-aided design of conveyors for coal mining. Examples of optimization tasks and methods for their solution using computerized simulation are analyzed. The analysis is illustrated by an algorithm used to design a starter for the drive system of a belt conveyor. Electromagnetic moment and starting current are used as optimization criteria. A simplified model of a belt conveyor is used. The model consists of an equation of motion with variable braking moment and variable moment of inertia. 3 references.

  5. Computer-aided translation tools

    DEFF Research Database (Denmark)

    Christensen, Tina Paulsen; Schjoldager, Anne

    2016-01-01

    The paper reports on a questionnaire survey from 2013 of the uptake and use of computer-aided translation (CAT) tools by Danish translation service providers (TSPs) and discusses how these tools appear to have impacted on the Danish translation industry. According to our results, the uptake in De...

  6. 选区激光熔化成型悬垂结构的计算机辅助工艺参数优化%Computer-Aided Optimization of the Process Parameters for Fabricating Overhanging Structure by Selective Laser Melting

    Institute of Scientific and Technical Information of China (English)

    刘杰; 杨永强; 王迪; 肖冬明; 苏旭彬

    2012-01-01

    To improve the fabricating quality of overhanging structure in selective laser melting < SLM), the computer-aided optimization of process parameters is studied, which focuses on the fabrication orientation and the power input. The optimization model of the fabrication orientation, which is aiming at reducing the difficultly fabricating overhanging surface area, is proposed. The genetic solution for the model is studied. The static lookup table to adjust the energy input duly is built by traversing all the triangles in the stereo lithography (STL) file. The experimental results show that the difficultly fabricating overhanging surface area reduces from 555. 12 mm2 to 16.211 mm2 after the optimization of the fabrication orientation, which leads to the less support needs, and the fabrication quality is obviously improved without so much overhang and deformation.%为了提高选区激光熔化(SLM)成型悬垂结构的质量,从调节成型方向和能量输入人手研究悬垂结构的计算机辅助工艺参数优化.以减小零件模型整体难成型悬垂面的面积为目标,以零件模型非成型方向的两个旋转角度为优化变量,建立成型方向的优化模型,并基于遗传算法实现优化模型参数的求解.通过遍历零件模型中的所有三角面片,建立倾斜角静态查找表,并在成型时查表实现能量输入的实时调节.实验结果表明,经成型方向优化,零件模型难成型悬垂面的面积从555.12 mm2减小为16.211 mm2,所需支撑数量明显减少;成型后所得零件无明显悬垂物和翘曲变形,成型质量明显改善.

  7. Computer-Aided Modeling Framework

    DEFF Research Database (Denmark)

    Fedorova, Marina; Sin, Gürkan; Gani, Rafiqul

    with them. As the required models may be complex and require multiple time and/or length scales, their development and application for product-process design is not trivial. Therefore, a systematic modeling framework can contribute by significantly reducing the time and resources needed for model...... development and application. The proposed work is a part of the project for development of methods and tools that will allow systematic generation, analysis and solution of models for various objectives. It will use the computer-aided modeling framework that is based on a modeling methodology, which combines....... In this contribution, the concept of template-based modeling is presented and application is highlighted for the specific case of catalytic membrane fixed bed models. The modeling template is integrated in a generic computer-aided modeling framework. Furthermore, modeling templates enable the idea of model reuse...

  8. Computer Aided Design of Couplings

    OpenAIRE

    2011-01-01

    The research work explores computer-aided approach to the design of ten different couplings, viza viz: flange, solid rigid, hollow rigid, old ham/ cross-sliding, pin type flexible, sleeve, seller cone/compression, split muff, pulley flange and fairbian’s lap-box couplings. The approach utilizesstandard design equations of these couplings and link them together in computer software todetermine the design parameters of the couplings. The work reviews the procedural stepsinvolved in the design o...

  9. Computer Aided Design of Couplings

    OpenAIRE

    2011-01-01

    The research work explores computer-aided approach to the design of ten different couplings, viz a viz: flange, solid rigid, hollow rigid, old ham/ cross-sliding, pin type flexible, sleeve, seller cone/ compression, split muff, pulley flange and fairbian’s lap-box couplings. The approach utilizes standard design equations of these couplings and link them together in computer software to determine the design parameters of the couplings. The work reviews the procedural steps involved in the des...

  10. Leading Edge Device Aerodynamic Optimization

    Directory of Open Access Journals (Sweden)

    Marius Gabriel COJOCARU

    2015-12-01

    Full Text Available Leading edge devices are conventionally used as aerodynamic devices that enhance performances during landing and in some cases during takeoff. The need to increase the efficiency of the aircrafts has brought the idea of maintaining as much as possible a laminar flow over the wings. This is possible only when the leading edge of the wings is free from contamination, therefore using the leading edge devices with the additional role of shielding during takeoff. Such a device based on the Krueger flap design is aerodynamically analyzed and optimized. The optimization comprises three steps: first, the positioning of the flap such that the shielding criterion is kept, second, the analysis of the flap size and third, the optimization of the flap shape. The first step is subject of a gradient based optimization process of the position described by two parameters, the position along the line and the deflection angle. For the third step the Adjoint method is used to gain insight on the shape of the Krueger flap that will extend the most the stall limit. All these steps have been numerically performed using Ansys Fluent and the results are presented for the optimized shape in comparison with the baseline configuration.

  11. On computer-aided design of aerospace vehicles

    Science.gov (United States)

    Sobieszczanski, J. E.; Voigt, S. J.; Fulton, R. E.

    1974-01-01

    Digital computers are being used in many engineering activities to support design work. This paper provides an overview of some of this work as it relates to the design of aerospace vehicles. Discussions are given of some of the complexities of the design process which lead to large design costs and time. A number of important but disjointed computer capabilities have evolved over the years in analysis, optimization, and graphics, and such capabilities aid in addressing the problem of design complexity. Examples of existing computer-aided design (CAD) systems are given and trends for future CAD systems are indicated, as well as their relationship to pertinent data management technology. It is suggested that major gains in design capability will occur through continued development of CAD methodology and that these gains may be accelerated through a large focused effort.

  12. Computer Aided Optimization Design of Riveted Joints in Aeronautics%计算机辅助飞机铆钉连接优化设计

    Institute of Scientific and Technical Information of China (English)

    高原; 于随然

    2014-01-01

    飞机铆钉连接设计涉及设计部门与计算部门,部门之间的数据交流过程不仅浪费大量时间,而且也会因为配合不协调导致数据版本等出现错误。为了优化飞机铆钉连接设计流程,文章提出了一种结合两个部门功能并利用设计者自身知识的计算机辅助设计方法,其核心是一个能够从多方面综合评价铆钉连接设计的算法以及一个友善的用户界面。将方法应用于SaM146涡轮发动机机舱铆钉连接设计,验证了其有效性。%Riveted joints design includes the design department and the calculation department. During the transmission of information between the two departments, a lot of time is wasted and it can easily lead to desynchroni-zation between departments. To optimize the design process of riveted joints in aeronautics, a method was brought out to solve this problem by combining the functions of these two departments and, at the same time, taking advantage of the designers’ expertise. The key elements of this method were a friendly user interface and an algorithm which can e-valuate riveted joints design from several aspects. Finally this method is applied to a riveted joints design in the na-celle of SaM146 turbofan engine and thus proves this method is both effective and efficient.

  13. Computer Aided Solvent Selection and Design Framework

    DEFF Research Database (Denmark)

    Mitrofanov, Igor; Conte, Elisa; Abildskov, Jens

    , millions of tons solvents have to be wasted every year [2]. Therefore, it becomes important to minimize and optimize the use of organic solvents as much as possible, to satisfy the “Green Chemistry Principles” [3]. Another challenge is that currently solvent selection relies very much on previous...... is to develop a systematic framework and implement it as software for selection and design of solvents for many applications including organic synthesis, complex reaction systems and solvent-based separations. The solvent selection framework is based on a combination of knowledge from industrial practice...... identification of solvent candidates using special software ProCAMD and ProPred, which are the implementations of computer-aided molecular techniques. The second consists of assigning the RS-indices following the reaction–solvent and then consulting the known solvent database and identifying the set of solvents...

  14. Computer-aided drug discovery research at a global contract research organization

    Science.gov (United States)

    Kitchen, Douglas B.

    2017-03-01

    Computer-aided drug discovery started at Albany Molecular Research, Inc in 1997. Over nearly 20 years the role of cheminformatics and computational chemistry has grown throughout the pharmaceutical industry and at AMRI. This paper will describe the infrastructure and roles of CADD throughout drug discovery and some of the lessons learned regarding the success of several methods. Various contributions provided by computational chemistry and cheminformatics in chemical library design, hit triage, hit-to-lead and lead optimization are discussed. Some frequently used computational chemistry techniques are described. The ways in which they may contribute to discovery projects are presented based on a few examples from recent publications.

  15. Computer-aided drug discovery research at a global contract research organization

    Science.gov (United States)

    Kitchen, Douglas B.

    2016-11-01

    Computer-aided drug discovery started at Albany Molecular Research, Inc in 1997. Over nearly 20 years the role of cheminformatics and computational chemistry has grown throughout the pharmaceutical industry and at AMRI. This paper will describe the infrastructure and roles of CADD throughout drug discovery and some of the lessons learned regarding the success of several methods. Various contributions provided by computational chemistry and cheminformatics in chemical library design, hit triage, hit-to-lead and lead optimization are discussed. Some frequently used computational chemistry techniques are described. The ways in which they may contribute to discovery projects are presented based on a few examples from recent publications.

  16. Quality Indexing with Computer-Aided Lexicography.

    Science.gov (United States)

    Buchan, R. L.

    1992-01-01

    Discussion of computer-aided indexing activity focuses on examples from projects at the National Aeronautics and Space Administration (NASA). Standardization and quality in providing subject access to databases are considered; and computer-aided lexicography, including thesaurus construction, access vocabulary, definitions preparation,…

  17. Computer Aided Design in Engineering Education.

    Science.gov (United States)

    Gobin, R.

    1986-01-01

    Discusses the use of Computer Aided Design (CAD) and Computer Aided Manufacturing (CAM) systems in an undergraduate engineering education program. Provides a rationale for CAD/CAM use in the already existing engineering program. Describes the methods used in choosing the systems, some initial results, and warnings for first-time users. (TW)

  18. User-Centered Computer Aided Language Learning

    Science.gov (United States)

    Zaphiris, Panayiotis, Ed.; Zacharia, Giorgos, Ed.

    2006-01-01

    In the field of computer aided language learning (CALL), there is a need for emphasizing the importance of the user. "User-Centered Computer Aided Language Learning" presents methodologies, strategies, and design approaches for building interfaces for a user-centered CALL environment, creating a deeper understanding of the opportunities and…

  19. Computer-aided system design

    Science.gov (United States)

    Walker, Carrie K.

    1991-01-01

    A technique has been developed for combining features of a systems architecture design and assessment tool and a software development tool. This technique reduces simulation development time and expands simulation detail. The Architecture Design and Assessment System (ADAS), developed at the Research Triangle Institute, is a set of computer-assisted engineering tools for the design and analysis of computer systems. The ADAS system is based on directed graph concepts and supports the synthesis and analysis of software algorithms mapped to candidate hardware implementations. Greater simulation detail is provided by the ADAS functional simulator. With the functional simulator, programs written in either Ada or C can be used to provide a detailed description of graph nodes. A Computer-Aided Software Engineering tool developed at the Charles Stark Draper Laboratory (CSDL CASE) automatically generates Ada or C code from engineering block diagram specifications designed with an interactive graphical interface. A technique to use the tools together has been developed, which further automates the design process.

  20. Computer Aided Battery Engineering Consortium

    Energy Technology Data Exchange (ETDEWEB)

    Pesaran, Ahmad

    2016-06-07

    A multi-national lab collaborative team was assembled that includes experts from academia and industry to enhance recently developed Computer-Aided Battery Engineering for Electric Drive Vehicles (CAEBAT)-II battery crush modeling tools and to develop microstructure models for electrode design - both computationally efficient. Task 1. The new Multi-Scale Multi-Domain model framework (GH-MSMD) provides 100x to 1,000x computation speed-up in battery electrochemical/thermal simulation while retaining modularity of particles and electrode-, cell-, and pack-level domains. The increased speed enables direct use of the full model in parameter identification. Task 2. Mechanical-electrochemical-thermal (MECT) models for mechanical abuse simulation were simultaneously coupled, enabling simultaneous modeling of electrochemical reactions during the short circuit, when necessary. The interactions between mechanical failure and battery cell performance were studied, and the flexibility of the model for various batteries structures and loading conditions was improved. Model validation is ongoing to compare with test data from Sandia National Laboratories. The ABDT tool was established in ANSYS. Task 3. Microstructural modeling was conducted to enhance next-generation electrode designs. This 3- year project will validate models for a variety of electrodes, complementing Advanced Battery Research programs. Prototype tools have been developed for electrochemical simulation and geometric reconstruction.

  1. Modeling and Multi-Objective Optimization of Engine Performance and Hydrocarbon Emissions via the Use of a Computer Aided Engineering Code and the NSGA-II Genetic Algorithm

    Directory of Open Access Journals (Sweden)

    Richard Fiifi Turkson

    2016-01-01

    Full Text Available It is feared that the increasing population of vehicles in the world and the depletion of fossil-based fuel reserves could render transportation and other activities that rely on fossil fuels unsustainable in the long term. Concerns over environmental pollution issues, the high cost of fossil-based fuels and the increasing demand for fossil fuels has led to the search for environmentally friendly, cheaper and efficient fuels. In the search for these alternatives, liquefied petroleum gas (LPG has been identified as one of the viable alternatives that could be used in place of gasoline in spark-ignition engines. The objective of the study was to present the modeling and multi-objective optimization of brake mean effective pressure and hydrocarbon emissions for a spark-ignition engine retrofitted to run on LPG. The use of a one-dimensional (1D GT-Power™ model, together with Group Method of Data Handling (GMDH neural networks, has been presented. The multi-objective optimization was implemented in MATLAB® using the non-dominated sorting genetic algorithm (NSGA-II. The modeling process generally achieved low mean squared errors (0.0000032 in the case of the hydrocarbon emissions model for the models developed and was attributed to the collection of a larger training sample data using the 1D engine model. The multi-objective optimization and subsequent decisions for optimal performance have also been presented.

  2. Computer-aided design for metabolic engineering.

    Science.gov (United States)

    Fernández-Castané, Alfred; Fehér, Tamás; Carbonell, Pablo; Pauthenier, Cyrille; Faulon, Jean-Loup

    2014-12-20

    The development and application of biotechnology-based strategies has had a great socio-economical impact and is likely to play a crucial role in the foundation of more sustainable and efficient industrial processes. Within biotechnology, metabolic engineering aims at the directed improvement of cellular properties, often with the goal of synthesizing a target chemical compound. The use of computer-aided design (CAD) tools, along with the continuously emerging advanced genetic engineering techniques have allowed metabolic engineering to broaden and streamline the process of heterologous compound-production. In this work, we review the CAD tools available for metabolic engineering with an emphasis, on retrosynthesis methodologies. Recent advances in genetic engineering strategies for pathway implementation and optimization are also reviewed as well as a range of bionalytical tools to validate in silico predictions. A case study applying retrosynthesis is presented as an experimental verification of the output from Retropath, the first complete automated computational pipeline applicable to metabolic engineering. Applying this CAD pipeline, together with genetic reassembly and optimization of culture conditions led to improved production of the plant flavonoid pinocembrin. Coupling CAD tools with advanced genetic engineering strategies and bioprocess optimization is crucial for enhanced product yields and will be of great value for the development of non-natural products through sustainable biotechnological processes.

  3. Computer-Aided Framework for the Design of Freeze-Drying Cycles: Optimization of the Operating Conditions of the Primary Drying Stage

    Directory of Open Access Journals (Sweden)

    Davide Fissore

    2015-05-01

    Full Text Available This paper deals with the freeze-drying process and, in particular, with the optimization of the operating conditions of the primary drying stage. When designing a freeze-drying cycle, process control aims at obtaining the values of the operating conditions (temperature of the heating fluid and pressure in the drying chamber resulting in a product temperature lower than the limit value of the product, and in the shortest drying time. This is particularly challenging, mainly due to the intrinsic nonlinearity of the system. In this framework, deep process knowledge is required for deriving a suitable process dynamic model that can be used to calculate the design space for the primary drying stage. The design space can then be used to properly design (and optimize the process, preserving product quality. The case of a product whose dried layer resistance, one of the key model parameters, is affected by the operating conditions is addressed in this paper, and a simple and effective method to calculate the design space in this case is presented and discussed.

  4. The computer-aided design of rubber-metal products

    Directory of Open Access Journals (Sweden)

    Pavlo S. Shvets

    2015-12-01

    Full Text Available The important problem in design of rubber-metal products is the optimization of their mass without sacrificing of proportionality factor is in the limits of standard. Aim: The aim of this work is to improve the computer-aided systems by development and implementation of improved optimization method in rubber-metal CAD systems for designers based on the reverse optimization. Materials and Methods: The paper studies the matters of computer-aided structural design of technical composite products composed of anisotropic materials that are essentially different in properties. Results: The structure of CAD systems for designers solving the problems of such design is offered and the work principles of its subsystems are described. It is shown that complicated systems optimization in CAD systems must consider as restrictions the entitative connection between separate elements of these systems within the area of the optimizing arguments. Conclusions: The problem of the “reverse” optimization when objective functions are the connectivity area parameters is considered. In many cases, this allows receiving solutions that are more effective during the computer-aided design process. The developed CAD system for designers was used during the production of rubber-metal shock absorbers at the Odessa Rubber Technical Articles Plant. The positive technical and economic effect was obtained.

  5. Planificación y optimización asistida por computadora de secuencias de ensamble mecánico // Computer aided Planning and optimization for mechanical assembly.

    Directory of Open Access Journals (Sweden)

    L. L. Tomás-García

    2009-01-01

    Full Text Available El presente trabajo versa sobre la generación, planificación y optimización de secuencias deensamble mecánico a partir de su modelo geométrico tridimensional. Se soporta sobre un enfoqueque integra tanto información geométrica como restricciones tecnológicas del proceso deensamble. En el desarrollo de la misma quedó demostrado, que una vez conocido el modelogeométrico tridimensional de un ensamble, la aplicación de criterios tecnológicos y geométricos alproceso inverso de desensamble y su posterior tratamiento con el método de algoritmosevolutivos, genera una planificación optimizada del su proceso de ensamble mecánico. Laintegración de la información permite disminuir el número de secuencias a evaluar y de elementosa procesar, con lo que se evita la generación y evaluación de todas las secuencias posibles con laconsecuente disminución del tiempo de procesamiento. Como resultado de la aplicación delmodelo integrado propuesto, se obtiene la planificación del proceso de ensamble mecánico conuna reducción del tiempo de ensamble debido a que en las secuencias de ensamble obtenidas sereduce el número de cambios de dirección de ensamble, los cambios de herramientas y de puestosde trabajo, así como se minimiza la distancia a recorrer debido al cambio de puestos de trabajo.Esto se logra mediante un modelo de optimización multiobjetivo basado en algoritmos evolutivos.Palabras claves: ensamble mecánico, algoritmos genéticos, optimización multiobjetivo.____________________________________________________________________________AbstractThis work deals with the combinatorial problem of generating and optimizing feasible assemblysequences and doing the process planning involving tools and work places. The assembly sequencesare obtained from a 3D model of the assembled parts based on mating conditions along with a setof technological criteria, which allows automatically analyzing and generating the sequences. Thegenerated

  6. Curved planar reformation and optimal path tracing (CROP) method for false positive reduction in computer-aided detection of pulmonary embolism in CTPA

    Science.gov (United States)

    Zhou, Chuan; Chan, Heang-Ping; Guo, Yanhui; Wei, Jun; Chughtai, Aamer; Hadjiiski, Lubomir M.; Sundaram, Baskaran; Patel, Smita; Kuriakose, Jean W.; Kazerooni, Ella A.

    2013-03-01

    The curved planar reformation (CPR) method re-samples the vascular structures along the vessel centerline to generate longitudinal cross-section views. The CPR technique has been commonly used in coronary CTA workstation to facilitate radiologists' visual assessment of coronary diseases, but has not yet been used for pulmonary vessel analysis in CTPA due to the complicated tree structures and the vast network of pulmonary vasculature. In this study, a new curved planar reformation and optimal path tracing (CROP) method was developed to facilitate feature extraction and false positive (FP) reduction and improve our PE detection system. PE candidates are first identified in the segmented pulmonary vessels at prescreening. Based on Dijkstra's algorithm, the optimal path (OP) is traced from the pulmonary trunk bifurcation point to each PE candidate. The traced vessel is then straightened and a reformatted volume is generated using CPR. Eleven new features that characterize the intensity, gradient, and topology are extracted from the PE candidate in the CPR volume and combined with the previously developed 9 features to form a new feature space for FP classification. With IRB approval, CTPA of 59 PE cases were retrospectively collected from our patient files (UM set) and 69 PE cases from the PIOPED II data set with access permission. 595 and 800 PEs were manually marked by experienced radiologists as reference standard for the UM and PIOPED set, respectively. At a test sensitivity of 80%, the average FP rate was improved from 18.9 to 11.9 FPs/case with the new method for the PIOPED set when the UM set was used for training. The FP rate was improved from 22.6 to 14.2 FPs/case for the UM set when the PIOPED set was used for training. The improvement in the free response receiver operating characteristic (FROC) curves was statistically significant (p<0.05) by JAFROC analysis, indicating that the new features extracted from the CROP method are useful for FP reduction.

  7. Computer-aided drug design at Boehringer Ingelheim

    Science.gov (United States)

    Muegge, Ingo; Bergner, Andreas; Kriegl, Jan M.

    2016-09-01

    Computer-Aided Drug Design (CADD) is an integral part of the drug discovery endeavor at Boehringer Ingelheim (BI). CADD contributes to the evaluation of new therapeutic concepts, identifies small molecule starting points for drug discovery, and develops strategies for optimizing hit and lead compounds. The CADD scientists at BI benefit from the global use and development of both software platforms and computational services. A number of computational techniques developed in-house have significantly changed the way early drug discovery is carried out at BI. In particular, virtual screening in vast chemical spaces, which can be accessed by combinatorial chemistry, has added a new option for the identification of hits in many projects. Recently, a new framework has been implemented allowing fast, interactive predictions of relevant on and off target endpoints and other optimization parameters. In addition to the introduction of this new framework at BI, CADD has been focusing on the enablement of medicinal chemists to independently perform an increasing amount of molecular modeling and design work. This is made possible through the deployment of MOE as a global modeling platform, allowing computational and medicinal chemists to freely share ideas and modeling results. Furthermore, a central communication layer called the computational chemistry framework provides broad access to predictive models and other computational services.

  8. Computer Aided Diagnosis in Digital Mammography

    Directory of Open Access Journals (Sweden)

    "H. Mirzaalian

    2005-08-01

    Full Text Available Introduction & Background: Breast cancer is a lead-ing cause of cancer deaths among women.Early de-tection is the most effective way to reduce mortality. Mammography is the best method for early detection. In order to improve the accuracy of interpretation of mammogram, Computer Aided Diagnosis (CAD sys-tems have been proposed. The main goal of this re-search is to implement one of the algorithms and techniques for the enhancement of mammogram for easier detection of abnormalities. Patients & Methods: In the presented algorithm, morphological methods are used first for removing artifacts. Then thresholding, labeling, and active con-tours methods are used to extract the breast region, which allow the search for abnormalities to be lim-ited to the region of the breast. Finally, Gaussian fil-ter and White Top Hat Transform is used for contrast enhancement of mammogram. This algorithm has been applied on 50 images from Mammography Im-age Analysis Society (MIAS. An expert radiologist then verified improvement on the processed images. Results and Conclusions: Implementing the presented algorithm causes easier and better interpretation of mammogram without increasing the number of false positive and false negative results. Because of the spe-cial shapes and statistical features of abnormal tex-tures, it is possible to apply pattern recognition and artificial intelligence techniques as an aid for diagnos-ing suspicious regions. Research on using some of these techniques to distinguish benign abnormalities from malignant ones is on the way.

  9. Computer-Aided Modeling of Lipid Processing Technology

    DEFF Research Database (Denmark)

    Diaz Tovar, Carlos Axel

    2011-01-01

    are widely used for design, analysis, and optimization of processes in the chemical and petrochemical industries. These computer-aided tools have helped the chemical industry to evolve beyond commodities toward specialty chemicals and ‘consumer oriented chemicals based products’. Unfortunately...... this is not the case for the edible oil and biodiesel industries. The oleochemical industry lags behind the chemical industry in terms of thermophysical property modeling and development of computational tools suitable for the design/analysis, and optimization of lipid-related processes. The aim of this work has been...... increase along with growing interest in biofuels, the oleochemical industry faces in the upcoming years major challenges in terms of design and development of better products and more sustainable processes to make them. Computer-aided methods and tools for process synthesis, modeling and simulation...

  10. Computer-Aided Drug Design Methods.

    Science.gov (United States)

    Yu, Wenbo; MacKerell, Alexander D

    2017-01-01

    Computational approaches are useful tools to interpret and guide experiments to expedite the antibiotic drug design process. Structure-based drug design (SBDD) and ligand-based drug design (LBDD) are the two general types of computer-aided drug design (CADD) approaches in existence. SBDD methods analyze macromolecular target 3-dimensional structural information, typically of proteins or RNA, to identify key sites and interactions that are important for their respective biological functions. Such information can then be utilized to design antibiotic drugs that can compete with essential interactions involving the target and thus interrupt the biological pathways essential for survival of the microorganism(s). LBDD methods focus on known antibiotic ligands for a target to establish a relationship between their physiochemical properties and antibiotic activities, referred to as a structure-activity relationship (SAR), information that can be used for optimization of known drugs or guide the design of new drugs with improved activity. In this chapter, standard CADD protocols for both SBDD and LBDD will be presented with a special focus on methodologies and targets routinely studied in our laboratory for antibiotic drug discoveries.

  11. Computer aided diagnosis of diabetic peripheral neuropathy

    Science.gov (United States)

    Chekh, Viktor; Soliz, Peter; McGrew, Elizabeth; Barriga, Simon; Burge, Mark; Luan, Shuang

    2014-03-01

    Diabetic peripheral neuropathy (DPN) refers to the nerve damage that can occur in diabetes patients. It most often affects the extremities, such as the feet, and can lead to peripheral vascular disease, deformity, infection, ulceration, and even amputation. The key to managing diabetic foot is prevention and early detection. Unfortunately, current existing diagnostic techniques are mostly based on patient sensations and exhibit significant inter- and intra-observer differences. We have developed a computer aided diagnostic (CAD) system for diabetic peripheral neuropathy. The thermal response of the feet of diabetic patients following cold stimulus is captured using an infrared camera. The plantar foot in the images from a thermal video are segmented and registered for tracking points or specific regions. The temperature recovery of each point on the plantar foot is extracted using our bio-thermal model and analyzed. The regions that exhibit abnormal ability to recover are automatically identified to aid the physicians to recognize problematic areas. The key to our CAD system is the segmentation of infrared video. The main challenges for segmenting infrared video compared to normal digital video are (1) as the foot warms up, it also warms up the surrounding, creating an ever changing contrast; and (2) there may be significant motion during imaging. To overcome this, a hybrid segmentation algorithm was developed based on a number of techniques such as continuous max-flow, model based segmentation, shape preservation, convex hull, and temperature normalization. Verifications of the automatic segmentation and registration using manual segmentation and markers show good agreement.

  12. Computer Aided Drug Design: Success and Limitations.

    Science.gov (United States)

    Baig, Mohammad Hassan; Ahmad, Khurshid; Roy, Sudeep; Ashraf, Jalaluddin Mohammad; Adil, Mohd; Siddiqui, Mohammad Haris; Khan, Saif; Kamal, Mohammad Amjad; Provazník, Ivo; Choi, Inho

    2016-01-01

    Over the last few decades, computer-aided drug design has emerged as a powerful technique playing a crucial role in the development of new drug molecules. Structure-based drug design and ligand-based drug design are two methods commonly used in computer-aided drug design. In this article, we discuss the theory behind both methods, as well as their successful applications and limitations. To accomplish this, we reviewed structure based and ligand based virtual screening processes. Molecular dynamics simulation, which has become one of the most influential tool for prediction of the conformation of small molecules and changes in their conformation within the biological target, has also been taken into account. Finally, we discuss the principles and concepts of molecular docking, pharmacophores and other methods used in computer-aided drug design.

  13. Computer-Aided Modelling Methods and Tools

    DEFF Research Database (Denmark)

    Cameron, Ian; Gani, Rafiqul

    2011-01-01

    The development of models for a range of applications requires methods and tools. In many cases a reference model is required that allows the generation of application specific models that are fit for purpose. There are a range of computer aided modelling tools available that help to define...... a taxonomy of aspects around conservation, constraints and constitutive relations. Aspects of the ICAS-MoT toolbox are given to illustrate the functionality of a computer aided modelling tool, which incorporates an interface to MS Excel....

  14. Computer Aided Modelling – Opportunities and Challenges

    DEFF Research Database (Denmark)

    2011-01-01

    This chapter considers the opportunities that are present in developing, extending and applying aspects of computer-aided modelling principles and practice. What are the best tasks to be done by modellers and what needs the application of CAPE tools? How do we efficiently develop model-based solu......This chapter considers the opportunities that are present in developing, extending and applying aspects of computer-aided modelling principles and practice. What are the best tasks to be done by modellers and what needs the application of CAPE tools? How do we efficiently develop model...

  15. Computer Aided Grid Interface: An Interactive CFD Pre-Processor

    Science.gov (United States)

    Soni, Bharat K.

    1997-01-01

    NASA maintains an applications oriented computational fluid dynamics (CFD) efforts complementary to and in support of the aerodynamic-propulsion design and test activities. This is especially true at NASA/MSFC where the goal is to advance and optimize present and future liquid-fueled rocket engines. Numerical grid generation plays a significant role in the fluid flow simulations utilizing CFD. An overall goal of the current project was to develop a geometry-grid generation tool that will help engineers, scientists and CFD practitioners to analyze design problems involving complex geometries in a timely fashion. This goal is accomplished by developing the CAGI: Computer Aided Grid Interface system. The CAGI system is developed by integrating CAD/CAM (Computer Aided Design/Computer Aided Manufacturing) geometric system output and/or Initial Graphics Exchange Specification (IGES) files (including all the NASA-IGES entities), geometry manipulations and generations associated with grid constructions, and robust grid generation methodologies. This report describes the development process of the CAGI system.

  16. Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates.

    Science.gov (United States)

    Xiao, Zhiyan; Morris-Natschke, Susan L; Lee, Kuo-Hsiung

    2016-01-01

    Natural products have made significant contribution to cancer chemotherapy over the past decades and remain an indispensable source of molecular and mechanistic diversity for anticancer drug discovery. More often than not, natural products may serve as leads for further drug development rather than as effective anticancer drugs by themselves. Generally, optimization of natural leads into anticancer drugs or drug candidates should not only address drug efficacy, but also improve absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiles and chemical accessibility associated with the natural leads. Optimization strategies involve direct chemical manipulation of functional groups, structure-activity relationship directed optimization and pharmacophore-oriented molecular design based on the natural templates. Both fundamental medicinal chemistry principles (e.g., bioisosterism) and state-of-the-art computer-aided drug design techniques (e.g., structure-based design) can be applied to facilitate optimization efforts. In this review, the strategies to optimize natural leads to anticancer drugs or drug candidates are illustrated with examples and described according to their purposes. Furthermore, successful case studies on lead optimization of bioactive compounds performed in the Natural Products Research Laboratories at UNC are highlighted.

  17. Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates

    Science.gov (United States)

    Xiao, Zhiyan; Morris-Natschke, Susan L.; Lee, Kuo-Hsiung

    2015-01-01

    Natural products have made significant contribution to cancer chemotherapy over the past decades and remain an indispensable source of molecular and mechanistic diversity for anticancer drug discovery. More often than not, natural products may serve as leads for further drug development rather than as effective anticancer drugs by themselves. Generally, optimization of natural leads into anticancer drugs or drug candidates should not only address drug efficacy, but also improve ADMET profiles and chemical accessibility associated with the natural leads. Optimization strategies involve direct chemical manipulation of functional groups, structure-activity relationship-directed optimization and pharmacophore-oriented molecular design based on the natural templates. Both fundamental medicinal chemistry principles (e.g., bio-isosterism) and state-of-the-art computer-aided drug design techniques (e.g., structure-based design) can be applied to facilitate optimization efforts. In this review, the strategies to optimize natural leads to anticancer drugs or drug candidates are illustrated with examples and described according to their purposes. Furthermore, successful case studies on lead optimization of bioactive compounds performed in the Natural Products Research Laboratories at UNC are highlighted. PMID:26359649

  18. Computer-Aided Medical Diagnosis. Literature Review

    Science.gov (United States)

    1978-12-15

    BOUCKAERT, A., Computer-aided diagnosis of goitres in a cancer department, Int. J. Bio-’Med. Comput., 3 (1972) p. 3. BOYLE, J. A., GREIG, W. R., FRANKLIN, D...toxic goitre , Q. J. Med., 35 (1966) p. 565. Bricetti, A. B. and Bleich, H. L., A computer program that evaluates patients with hypercalcemia, J

  19. Computer-Aided Corrosion Program Management

    Science.gov (United States)

    MacDowell, Louis

    2010-01-01

    This viewgraph presentation reviews Computer-Aided Corrosion Program Management at John F. Kennedy Space Center. The contents include: 1) Corrosion at the Kennedy Space Center (KSC); 2) Requirements and Objectives; 3) Program Description, Background and History; 4) Approach and Implementation; 5) Challenges; 6) Lessons Learned; 7) Successes and Benefits; and 8) Summary and Conclusions.

  20. Computer Aided Continuous Time Stochastic Process Modelling

    DEFF Research Database (Denmark)

    Kristensen, N.R.; Madsen, Henrik; Jørgensen, Sten Bay

    2001-01-01

    A grey-box approach to process modelling that combines deterministic and stochastic modelling is advocated for identification of models for model-based control of batch and semi-batch processes. A computer-aided tool designed for supporting decision-making within the corresponding modelling cycle...

  1. Computer aided pantograph design for garment panels

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Discusses the difficulties and problems with manual pantograph ofgarment panels, introduces several typical pantographic ways and their characteristics both at home and abroad, presents a new pantographic method based on similar figures developed to overcome the deficiency of those methods, so as to realize computer aid automatic panel pantograph.

  2. Computer Aided Control System Design (CACSD)

    Science.gov (United States)

    Stoner, Frank T.

    1993-01-01

    The design of modern aerospace systems relies on the efficient utilization of computational resources and the availability of computational tools to provide accurate system modeling. This research focuses on the development of a computer aided control system design application which provides a full range of stability analysis and control design capabilities for aerospace vehicles.

  3. Evaluation of computer-aided detection and diagnosis systems.

    Science.gov (United States)

    Petrick, Nicholas; Sahiner, Berkman; Armato, Samuel G; Bert, Alberto; Correale, Loredana; Delsanto, Silvia; Freedman, Matthew T; Fryd, David; Gur, David; Hadjiiski, Lubomir; Huo, Zhimin; Jiang, Yulei; Morra, Lia; Paquerault, Sophie; Raykar, Vikas; Samuelson, Frank; Summers, Ronald M; Tourassi, Georgia; Yoshida, Hiroyuki; Zheng, Bin; Zhou, Chuan; Chan, Heang-Ping

    2013-08-01

    Computer-aided detection and diagnosis (CAD) systems are increasingly being used as an aid by clinicians for detection and interpretation of diseases. Computer-aided detection systems mark regions of an image that may reveal specific abnormalities and are used to alert clinicians to these regions during image interpretation. Computer-aided diagnosis systems provide an assessment of a disease using image-based information alone or in combination with other relevant diagnostic data and are used by clinicians as a decision support in developing their diagnoses. While CAD systems are commercially available, standardized approaches for evaluating and reporting their performance have not yet been fully formalized in the literature or in a standardization effort. This deficiency has led to difficulty in the comparison of CAD devices and in understanding how the reported performance might translate into clinical practice. To address these important issues, the American Association of Physicists in Medicine (AAPM) formed the Computer Aided Detection in Diagnostic Imaging Subcommittee (CADSC), in part, to develop recommendations on approaches for assessing CAD system performance. The purpose of this paper is to convey the opinions of the AAPM CADSC members and to stimulate the development of consensus approaches and "best practices" for evaluating CAD systems. Both the assessment of a standalone CAD system and the evaluation of the impact of CAD on end-users are discussed. It is hoped that awareness of these important evaluation elements and the CADSC recommendations will lead to further development of structured guidelines for CAD performance assessment. Proper assessment of CAD system performance is expected to increase the understanding of a CAD system's effectiveness and limitations, which is expected to stimulate further research and development efforts on CAD technologies, reduce problems due to improper use, and eventually improve the utility and efficacy of CAD in

  4. Computer-aided Framework for Design of Pure, Mixed and Blended Products

    DEFF Research Database (Denmark)

    2015-01-01

    This paper presents a framework for computer-aided design of pure, mixed and blended chemical based products. The framework is a systematic approach to convert a Computer-aided Molecular, Mixture and Blend Design (CAMbD) formulation, based on needs and target properties, into a mixed integer non-......-linear program (MINLP). TheMINLP is sequentially solved through a decomposed optimization approach to solve the possibly large MINLP in a smaller set of sub-problems. The framework application is highlighted through a solvent design case study.......This paper presents a framework for computer-aided design of pure, mixed and blended chemical based products. The framework is a systematic approach to convert a Computer-aided Molecular, Mixture and Blend Design (CAMbD) formulation, based on needs and target properties, into a mixed integer non...

  5. Computer-aided Framework for Design of Pure, Mixed and Blended Products

    DEFF Research Database (Denmark)

    Cignitti, Stefano; Zhang, Lei; Gani, Rafiqul

    2015-01-01

    Design of novel chemical products with process and application considerations is an emerging topic in thefield of chemical and biochemical engineering. Methods, such as Computer Aided Molecular Design(CAMD) [1] and Computer-aided Mixture and Blend Design (CAMbD) [2], provide the possibility of de...... a solvent design case study.......Design of novel chemical products with process and application considerations is an emerging topic in thefield of chemical and biochemical engineering. Methods, such as Computer Aided Molecular Design(CAMD) [1] and Computer-aided Mixture and Blend Design (CAMbD) [2], provide the possibility...... of designing such products. However, these product design problems can quickly become large and difficult, if not infeasible, to solve through mathematical optimization. In addition, considerations of process,application, special product attributes, economic feasibility, environmental and sustainability...

  6. A Novel Computer-Aided Approach for Parametric Investigation of Custom Design of Fracture Fixation Plates.

    Science.gov (United States)

    Chen, Xiaozhong; He, Kunjin; Chen, Zhengming

    2017-01-01

    The present study proposes an integrated computer-aided approach combining femur surface modeling, fracture evidence recover plate creation, and plate modification in order to conduct a parametric investigation of the design of custom plate for a specific patient. The study allows for improving the design efficiency of specific plates on the patients' femur parameters and the fracture information. Furthermore, the present approach will lead to exploration of plate modification and optimization. The three-dimensional (3D) surface model of a detailed femur and the corresponding fixation plate were represented with high-level feature parameters, and the shape of the specific plate was recursively modified in order to obtain the optimal plate for a specific patient. The proposed approach was tested and verified on a case study, and it could be helpful for orthopedic surgeons to design and modify the plate in order to fit the specific femur anatomy and the fracture information.

  7. A Novel Computer-Aided Approach for Parametric Investigation of Custom Design of Fracture Fixation Plates

    Science.gov (United States)

    2017-01-01

    The present study proposes an integrated computer-aided approach combining femur surface modeling, fracture evidence recover plate creation, and plate modification in order to conduct a parametric investigation of the design of custom plate for a specific patient. The study allows for improving the design efficiency of specific plates on the patients' femur parameters and the fracture information. Furthermore, the present approach will lead to exploration of plate modification and optimization. The three-dimensional (3D) surface model of a detailed femur and the corresponding fixation plate were represented with high-level feature parameters, and the shape of the specific plate was recursively modified in order to obtain the optimal plate for a specific patient. The proposed approach was tested and verified on a case study, and it could be helpful for orthopedic surgeons to design and modify the plate in order to fit the specific femur anatomy and the fracture information. PMID:28203270

  8. Creating illusion in computer aided performance

    OpenAIRE

    Marshall, Joe

    2009-01-01

    This thesis studies the creation of illusion in computer aided performance. Illusion is created here by using deceptions, and a design framework is presented which suggests several different deception strategies which may be useful. The framework has been developed in an iterative process in tandem with the development of 3 real world performances which were used to explore deception strategies. The first case study presents a system for augmenting juggling performance. The techniques tha...

  9. Computer-Aided Pneumatic Circuit Design

    OpenAIRE

    TEKİNER, Zafer; KORKUT, İhsan

    2001-01-01

    In this study, a user-interactive computer program was developed for computer-aided pneumatic circuit design. The pneumatic circuit elements were selected and designed by the determination of the main principles that are in accordance with the aim the user is going to specify. A database was established by forming IGES files for pneumatic circuit elements. In addition to this database, lists displaying the connection nodes of each element were prepared. The coordinates will be conne...

  10. Genetic algorithms in computer aided inductor design

    OpenAIRE

    Jean Fivaz; Willem A. Cronjé

    2004-01-01

    The goal of this investigation is to determine the advantages of using genetic algorithms in computer-aided design as applied to inductors.  These advantages are exploited in design problems with a number of specifications and constraints, as encountered in power electronics during practical inductor design. The design tool should be able to select components, such as cores and wires, from databases of available components, and evaluate these choices based on the components’ characteristic d...

  11. Computer-aided dispatching system design specification

    Energy Technology Data Exchange (ETDEWEB)

    Briggs, M.G.

    1997-12-16

    This document defines the performance requirements for a graphic display dispatching system to support Hanford Patrol Operations Center. This document reflects the as-built requirements for the system that was delivered by GTE Northwest, Inc. This system provided a commercial off-the-shelf computer-aided dispatching system and alarm monitoring system currently in operations at the Hanford Patrol Operations Center, Building 2721E. This system also provides alarm back-up capability for the Plutonium Finishing Plant (PFP).

  12. Genetic algorithms in computer aided inductor design

    Directory of Open Access Journals (Sweden)

    Jean Fivaz

    2004-09-01

    Full Text Available The goal of this investigation is to determine the advantages of using genetic algorithms in computer-aided design as applied to inductors.  These advantages are exploited in design problems with a number of specifications and constraints, as encountered in power electronics during practical inductor design. The design tool should be able to select components, such as cores and wires, from databases of available components, and evaluate these choices based on the components’ characteristic data read from a database of manufacturers’ data-sheets.  The proposed design must always be practically realizable, as close to the desired specifications as possible and within any specified constraints.

  13. Computer Aided Modelling – Opportunities and Challenges

    DEFF Research Database (Denmark)

    Cameron, Ian; Gani, Rafiqul

    2011-01-01

    -based solutions to significant problems? The important issues of workflow and data flow are discussed together with fit-for-purpose model development. As well, the lack of tools around multiscale modelling provides opportunities for the development of efficient tools to address such challenges. The ability......This chapter considers the opportunities that are present in developing, extending and applying aspects of computer-aided modelling principles and practice. What are the best tasks to be done by modellers and what needs the application of CAPE tools? How do we efficiently develop model...... and opportunities are discussed for such systems....

  14. Quality indexing with computer-aided lexicography

    Science.gov (United States)

    Buchan, Ronald L.

    1992-01-01

    Indexing with computers is a far cry from indexing with the first indexing tool, the manual card sorter. With the aid of computer-aided lexicography, both indexing and indexing tools can provide standardization, consistency, and accuracy, resulting in greater quality control than ever before. A brief survey of computer activity in indexing is presented with detailed illustrations from NASA activity. Applications from techniques mentioned, such as Retrospective Indexing (RI), can be made to many indexing systems. In addition to improving the quality of indexing with computers, the improved efficiency with which certain tasks can be done is demonstrated.

  15. Computer-aided power systems analysis

    CERN Document Server

    Kusic, George

    2008-01-01

    Computer applications yield more insight into system behavior than is possible by using hand calculations on system elements. Computer-Aided Power Systems Analysis: Second Edition is a state-of-the-art presentation of basic principles and software for power systems in steady-state operation. Originally published in 1985, this revised edition explores power systems from the point of view of the central control facility. It covers the elements of transmission networks, bus reference frame, network fault and contingency calculations, power flow on transmission networks, generator base power setti

  16. Speech-enabled Computer-aided Translation

    DEFF Research Database (Denmark)

    Mesa-Lao, Bartolomé

    2014-01-01

    The present study has surveyed post-editor trainees’ views and attitudes before and after the introduction of speech technology as a front end to a computer-aided translation workbench. The aim of the survey was (i) to identify attitudes and perceptions among post-editor trainees before performing...... a post-editing task using automatic speech recognition (ASR); and (ii) to assess the degree to which post-editors’ attitudes and expectations to the use of speech technology changed after actually using it. The survey was based on two questionnaires: the first one administered before the participants...

  17. Integrated computer-aided design using minicomputers

    Science.gov (United States)

    Storaasli, O. O.

    1980-01-01

    Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM), a highly interactive software, has been implemented on minicomputers at the NASA Langley Research Center. CAD/CAM software integrates many formerly fragmented programs and procedures into one cohesive system; it also includes finite element modeling and analysis, and has been interfaced via a computer network to a relational data base management system and offline plotting devices on mainframe computers. The CAD/CAM software system requires interactive graphics terminals operating at a minimum of 4800 bits/sec transfer rate to a computer. The system is portable and introduces 'interactive graphics', which permits the creation and modification of models interactively. The CAD/CAM system has already produced designs for a large area space platform, a national transonic facility fan blade, and a laminar flow control wind tunnel model. Besides the design/drafting element analysis capability, CAD/CAM provides options to produce an automatic program tooling code to drive a numerically controlled (N/C) machine. Reductions in time for design, engineering, drawing, finite element modeling, and N/C machining will benefit productivity through reduced costs, fewer errors, and a wider range of configuration.

  18. Computer-aided light sheet flow visualization

    Science.gov (United States)

    Stacy, Kathryn; Severance, Kurt; Childers, Brooks A.

    1993-01-01

    A computer-aided flow visualization process has been developed to analyze video images acquired from rotating and translating light sheet visualization systems. The computer process integrates a mathematical model for image reconstruction, advanced computer graphics concepts, and digital image processing to provide a quantitative and visual analysis capability. The image reconstruction model, based on photogrammetry, uses knowledge of the camera and light sheet locations and orientations to project two-dimensional light sheet video images into three-dimensional space. A sophisticated computer visualization package, commonly used to analyze computational fluid dynamics (CFD) data sets, was chosen to interactively display the reconstructed light sheet images, along with the numerical surface geometry for the model or aircraft under study. A description is provided of the photogrammetric reconstruction technique, and the image processing and computer graphics techniques and equipment. Results of the computer aided process applied to both a wind tunnel translating light sheet experiment and an in-flight rotating light sheet experiment are presented. The capability to compare reconstructed experimental light sheet images and CFD solutions in the same graphics environment is also demonstrated.

  19. Shape Signatures: speeding up computer aided drug discovery.

    Science.gov (United States)

    Meek, Peter J; Liu, ZhiWei; Tian, LiFeng; Wang, Ching Y; Welsh, William J; Zauhar, Randy J

    2006-10-01

    Identifying potential lead molecules is becoming a more automated process. We review Shape Signatures, a tool that is effective and easy to use compared with most computer aided drug design techniques. Laboratory researchers can apply this in silico technique cost-effectively without the need for specialized computer backgrounds. Identifying a potential lead molecule requires database screening, and this becomes rate-limiting once the database becomes too large. The use of Shape Signatures eliminates this concern and offers molecule screening rates that are in advance of any currently available method. Shape Signatures provides a conduit for researchers to conduct rapid identification of potential active molecules, and studies with this tool can be initiated with only one bioactive lead or receptor site.

  20. From Phonomecanocardiography to Phonocardiography computer aided

    Science.gov (United States)

    Granados, J.; Tavera, F.; López, G.; Velázquez, J. M.; Hernández, R. T.; López, G. A.

    2017-01-01

    Due to lack of training doctors to identify many of the disorders in the heart by conventional listening, it is necessary to add an objective and methodological analysis to support this technique. In order to obtain information of the performance of the heart to be able to diagnose heart disease through a simple, cost-effective procedure by means of a data acquisition system, we have obtained Phonocardiograms (PCG), which are images of the sounds emitted by the heart. A program of acoustic, visual and artificial vision recognition was elaborated to interpret them. Based on the results of previous research of cardiologists a code of interpretation of PCG and associated diseases was elaborated. Also a site, within the university campus, of experimental sampling of cardiac data was created. Phonocardiography computer-aided is a viable and low cost procedure which provides additional medical information to make a diagnosis of complex heart diseases. We show some previous results.

  1. Computer Aided in situ Cognitive Behavioral Therapy

    DEFF Research Database (Denmark)

    Chongtay, Rocio A.; Hansen, John Paulin; Decker, Lone

    2006-01-01

    This article describes the development of a system intended to aid the treatment of certain phobic conditions by the use of computer telephony integration (CTI).A phobia is an irrational fear to some situations or things and interferes with the functioning of the individual that suffers from it....... One of the most common and successfully used treatments for phobic conditions has been Cognitive Behavioral Therapy (CBT), which helps people learn to detect thinking patterns that trigger the irrational fear and to replace them with more realistic ideas. The health and financial impacts in society...... present a strong motivation to find ways to help in the treatment of these disorders. Access to treatment can be limited by the availability of trained mental health professionals, and more patients could get help if the therapist could delegate part of the treatment to computer-aided CBT. The system...

  2. Computer-Aided Design of Antimicrobial Peptides

    DEFF Research Database (Denmark)

    Fjell, Christopher D.; Hancock, Robert E.W.; Jenssen, Håvard

    2010-01-01

    chemical parameters with biological activities of the peptide, using statistical methods. In this review we will discuss two different in silico strategies of computer-aided antibacterial peptide design, a linear correlation model build as an extension of traditional principal component analysis (PCA......) and a non-linear artificial neural network model. Studies on structurally diverse peptides, have concluded that the PCA derived model are able to guide the antibacterial peptide design in a meaningful way, however requiring rather a high homology between the peptides in the test-set and the in silico...... library, to ensure a successful prediction. In contrast, the neural network model, though significantly less explored in relation to antimicrobial peptide design, has proven extremely promising, demonstrating impressive prediction success and ranking of random peptide libraries correlating well...

  3. COMPUTER AIDED DESIGN OF CUTTING TOOLS

    Directory of Open Access Journals (Sweden)

    Jakub Matuszak

    2015-11-01

    Full Text Available Correct and stable machining process requires an appropriate cutting tool. In most cases the tool can be selected by using special tool catalogs often available in online version. But in some cases there is a need to design unusual tools, for special treatment, which are not available in tool manufacturers’ catalogs. Proper tool design requires strength and geometric calculations. Moreover, in many cases specific technical documentation is required. By using Computer Aided Design of cutting tools this task can be carried out quickly and with high accuracy. Cutting tool visualization in CAD programs gives a clear overview of the design process. Besides, these programs provide the ability to simulate real machining process. Nowadays, 3D modeling in CAD programs is a fundamental tool for engineers. Therefore, it is important to use them in the education process.

  4. Computer Aided Design Modeling for Heterogeneous Objects

    CERN Document Server

    Gupta, Vikas; Tandon, Puneet

    2010-01-01

    Heterogeneous object design is an active research area in recent years. The conventional CAD modeling approaches only provide geometry and topology of the object, but do not contain any information with regard to the materials of the object and so can not be used for the fabrication of heterogeneous objects (HO) through rapid prototyping. Current research focuses on computer-aided design issues in heterogeneous object design. A new CAD modeling approach is proposed to integrate the material information into geometric regions thus model the material distributions in the heterogeneous object. The gradient references are used to represent the complex geometry heterogeneous objects which have simultaneous geometry intricacies and accurate material distributions. The gradient references helps in flexible manipulability and control to heterogeneous objects, which guarantees the local control over gradient regions of developed heterogeneous objects. A systematic approach on data flow, processing, computer visualizat...

  5. Energy-aware memory management for embedded multimedia systems a computer-aided design approach

    CERN Document Server

    Balasa, Florin

    2011-01-01

    Energy-Aware Memory Management for Embedded Multimedia Systems: A Computer-Aided Design Approach presents recent computer-aided design (CAD) ideas that address memory management tasks, particularly the optimization of energy consumption in the memory subsystem. It explains how to efficiently implement CAD solutions, including theoretical methods and novel algorithms. The book covers various energy-aware design techniques, including data-dependence analysis techniques, memory size estimation methods, extensions of mapping approaches, and memory banking approaches. It shows how these techniques

  6. Computer-Aided Model Based Analysis for Design and Operation of a Copolymerization Process

    DEFF Research Database (Denmark)

    Lopez-Arenas, Maria Teresa; Sales-Cruz, Alfonso Mauricio; Gani, Rafiqul

    2006-01-01

    The advances in computer science and computational algorithms for process modelling, process simulation, numerical methods and design/synthesis algorithms, makes it advantageous and helpful to employ computer-aided modelling systems and tools for integrated process analysis. This is illustrated....... This will allow analysis of the process behaviour, contribute to a better understanding of the polymerization process, help to avoid unsafe conditions of operation, and to develop operational and optimizing control strategies. In this work, through a computer-aided modeling system ICAS-MoT, two first......, the process design and conditions of operation on the polymer grade and the production rate....

  7. Evolution of Geometric Sensitivity Derivatives from Computer Aided Design Models

    Science.gov (United States)

    Jones, William T.; Lazzara, David; Haimes, Robert

    2010-01-01

    The generation of design parameter sensitivity derivatives is required for gradient-based optimization. Such sensitivity derivatives are elusive at best when working with geometry defined within the solid modeling context of Computer-Aided Design (CAD) systems. Solid modeling CAD systems are often proprietary and always complex, thereby necessitating ad hoc procedures to infer parameter sensitivity. A new perspective is presented that makes direct use of the hierarchical associativity of CAD features to trace their evolution and thereby track design parameter sensitivity. In contrast to ad hoc methods, this method provides a more concise procedure following the model design intent and determining the sensitivity of CAD geometry directly to its respective defining parameters.

  8. On Combining Multiple-Instance Learning and Active Learning for Computer-Aided Detection of Tuberculosis

    NARCIS (Netherlands)

    Melendez Rodriguez, J.C.; Ginneken, B. van; Maduskar, P.; Philipsen, R.H.H.M.; Ayles, H.; Sanchez, C.I.

    2016-01-01

    The major advantage of multiple-instance learning (MIL) applied to a computer-aided detection (CAD) system is that it allows optimizing the latter with case-level labels instead of accurate lesion outlines as traditionally required for a supervised approach. As shown in previous work, a MIL-based

  9. The computer-aided design of a servo system as a multiple-criteria decision problem

    NARCIS (Netherlands)

    Udink ten Cate, A.J.

    1986-01-01

    This paper treats the selection of controller gains of a servo system as a multiple-criteria decision problem. In contrast to the usual optimization-based approaches to computer-aided design, inequality constraints are included in the problem as unconstrained objectives. This considerably simplifies

  10. 一种用于计算机辅助产物设计中基于BP-NN优化问题的求解方法%A Method for Solving Computer-Aided Product Design Optimization Problem Based on Back Propagation Neural Network

    Institute of Scientific and Technical Information of China (English)

    周祥; 何小荣; 陈丙珍

    2004-01-01

    Because of the powerful mapping ability, back propagation neural network (BP-NN) has been employed in computer-aided product design (CAPD) to establish the property prediction model. The backward problem in CAPD is to search for the appropriate structure or composition of the product with desired property, which is an optimization problem. In this paper, a global optimization method of using the α BB algorithm to solve the backward problem is presented. In particular, a convex lower bounding function is constructed for the objective function formulated with BP-NN model, and the calculation of the key parameter α is implemented by recurring to the interval Hessian matrix of the objective function. Two case studies involving the design of dopamine β-hydroxylase (DβH) inhibitors and linear low density polyethylene (LLDPE) nano composites are investigated using the proposed method.

  11. Removal of Supernumerary Teeth Utilizing a Computer-Aided Design/Computer-Aided Manufacturing Surgical Guide.

    Science.gov (United States)

    Jo, Chanwoo; Bae, Doohwan; Choi, Byungho; Kim, Jihun

    2017-05-01

    Supernumerary teeth need to be removed because they can cause various complications. Caution is needed because their removal can cause damage to permanent teeth or tooth germs in the local vicinity. Surgical guides have recently been used in maxillofacial surgery. Because surgical guides are designed through preoperative analysis by computer-aided design software and fabricated using a 3-dimensional printer applying computer-aided manufacturing technology, they increase the accuracy and predictability of surgery. This report describes 2 cases of removal of a mesiodens-1 from a child and 1 from an adolescent-using a surgical guide; these would have been difficult to remove with conventional surgical methods. Copyright © 2016 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  12. Data-driven computer aided synthesis design.

    Science.gov (United States)

    Ravitz, Orr

    2013-09-01

    Enabled by an increasing body of electronically available experimental data and by advances in computer hardware and software, new technologies are emerging that are designed to support the creativity of chemists during synthesis planning. Leading this development are innovative synthetic route prediction tools that are designed to suggest new reactions and paths to target molecules as an idea-generating engine. Other tools are using known reactions in a combinatorial fashion to suggest new routes that are cost-optimized or satisfy some other global criteria. We review the latest developments and the main tools in this domain.

  13. Research on the Procedure for Computer-Aided Pattern Design of Uygur's Flowered Hats

    Directory of Open Access Journals (Sweden)

    Shuxian Liu

    2013-05-01

    Full Text Available Xinjiang Uygur’s flowered hats is famous all over the world, it leads the world of headwear of variou nationalities within China by the variety of styles, the various ways of how to emroider pattern design and exquisite manufacture. It is unusual even in national costumes art of the world. The poupose of this study is to analyze Uygur's headwear, study the rules of Uygur's headwear pattern, analyze the characteristic of the basic pattern, research on the procedure for computer-aided pattern design of Uygur's flowered hat, explore the application of computer-aided design in traditional costume's pattern design and to realize application exploration of computer-aided design in designing of costume and dress adornment.

  14. Computer Aided Interpretation Approach for Optical Tomographic Images

    CERN Document Server

    Klose, Christian D; Netz, Uwe; Beuthan, Juergen; Hielscher, Andreas H

    2010-01-01

    A computer-aided interpretation approach is proposed to detect rheumatic arthritis (RA) of human finger joints in optical tomographic images. The image interpretation method employs a multi-variate signal detection analysis aided by a machine learning classification algorithm, called Self-Organizing Mapping (SOM). Unlike in previous studies, this allows for combining multiple physical image parameters, such as minimum and maximum values of the absorption coefficient for identifying affected and not affected joints. Classification performances obtained by the proposed method were evaluated in terms of sensitivity, specificity, Youden index, and mutual information. Different methods (i.e., clinical diagnostics, ultrasound imaging, magnet resonance imaging and inspection of optical tomographic images), were used as "ground truth"-benchmarks to determine the performance of image interpretations. Using data from 100 finger joints, findings suggest that some parameter combinations lead to higher sensitivities while...

  15. Computer- Aided Design in Power Engineering Application of Software Tools

    CERN Document Server

    Stojkovic, Zlatan

    2012-01-01

    This textbooks demonstrates the application of software tools in solving a series of problems from the field of designing power system structures and systems. It contains four chapters: The first chapter leads the reader through all the phases necessary in the procedures of computer aided modeling and simulation. It guides through the complex problems presenting on the basis of eleven original examples. The second chapter presents  application of software tools in power system calculations of power systems equipment design. Several design example calculations are carried out using engineering standards like MATLAB, EMTP/ATP, Excel & Access, AutoCAD and Simulink. The third chapters focuses on the graphical documentation using a collection of software tools (AutoCAD, EPLAN, SIMARIS SIVACON, SIMARIS DESIGN) which enable the complete automation of the development of graphical documentation of a power systems. In the fourth chapter, the application of software tools in the project management in power systems ...

  16. Computer-Aided Detection of Polyps in CT Colonography Using Logistic Regression

    NARCIS (Netherlands)

    Van Ravesteijn, V.F.; Van Wijk, C.; Vos, F.M.; Truyen, R.; Peters, J.F.; Stoker, J.; Van Vliet, L.J.

    2010-01-01

    We present a computer-aided detection (CAD) system for computed tomography colonography that orders the polyps according to clinical relevance. TheCADsystem consists of two steps: candidate detection and supervised classification. The characteristics of the detection step lead to specific choices fo

  17. Software For Computer-Aided Design Of Control Systems

    Science.gov (United States)

    Wette, Matthew

    1994-01-01

    Computer Aided Engineering System (CAESY) software developed to provide means to evaluate methods for dealing with users' needs in computer-aided design of control systems. Interpreter program for performing engineering calculations. Incorporates features of both Ada and MATLAB. Designed to be flexible and powerful. Includes internally defined functions, procedures and provides for definition of functions and procedures by user. Written in C language.

  18. Intelligent Image Based Computer Aided Education (IICAE)

    Science.gov (United States)

    David, Amos A.; Thiery, Odile; Crehange, Marion

    1989-03-01

    Artificial Intelligence (AI) has found its way into Computer Aided Education (CAE), and there are several systems constructed to put in evidence its interesting advantages. We believe that images (graphic or real) play an important role in learning. However, the use of images, outside their use as illustration, makes it necessary to have applications such as AI. We shall develop the application of AI in an image based CAE and briefly present the system under construction to put in evidence our concept. We shall also elaborate a methodology for constructing such a system. Futhermore we shall briefly present the pedagogical and psychological activities in a learning process. Under the pedagogical and psychological aspect of learning, we shall develop areas such as the importance of image in learning both as pedagogical objects as well as means for obtaining psychological information about the learner. We shall develop the learner's model, its use, what to build into it and how. Under the application of AI in an image based CAE, we shall develop the importance of AI in exploiting the knowledge base in the learning environment and its application as a means of implementing pedagogical strategies.

  19. A computer-aided continuous assessment system

    Directory of Open Access Journals (Sweden)

    B. C.H. Turton

    1996-12-01

    Full Text Available Universities within the United Kingdom have had to cope with a massive expansion in undergraduate student numbers over the last five years (Committee of Scottish University Principals, 1993; CVCP Briefing Note, 1994. In addition, there has been a move towards modularization and a closer monitoring of a student's progress throughout the year. Since the price/performance ratio of computer systems has continued to improve, Computer- Assisted Learning (CAL has become an attractive option. (Fry, 1990; Benford et al, 1994; Laurillard et al, 1994. To this end, the Universities Funding Council (UFQ has funded the Teaching and Learning Technology Programme (TLTP. However universities also have a duty to assess as well as to teach. This paper describes a Computer-Aided Assessment (CAA system capable of assisting in grading students and providing feedback. In this particular case, a continuously assessed course (Low-Level Languages of over 100 students is considered. Typically, three man-days are required to mark one assessed piece of coursework from the students in this class. Any feedback on how the questions were dealt with by the student are of necessity brief. Most of the feedback is provided in a tutorial session that covers the pitfalls encountered by the majority of the students.

  20. Computer aided materials design; Keisanki zairyo sekkei

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    The questionnaire survey on the computer aided materials design (CAMD), and the survey of current domestic and overseas software concerned were carried out to clarify developmental issues. The current elementary technology of CAMD was also surveyed to study its several problems caused with a progress of material design technology due to drastic diffusion of CAMD. This project aims at establishment of a new demanded software, computer chemistry, focusing attention on functional materials such as catalyst, polymer and non-linear electronic materials. Microscopic simulation technology was mainly surveyed in fiscal 1996. Although some fruitful results have been obtained in the fields of medical and agricultural chemicals, organic compounds, proteins, catalysts and electronic materials, such some problems are pointed out as `CAMD cannot handle an actual size of the target system` and `commercially available software are very expensive.` Reliable tool development as elementary technology, and the verification of its applications are thus required. Meso-dynamics, polymers, surface reaction and integrated technological environment attract users` attention. 27 refs., 16 figs., 2 tabs.

  1. Computer Aided Software Engineering workstation evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Kotcher, D.A.; Parish, R.B.; Sisson, A.M.; Wenzel, W.A.; Wiancko, B.E.

    1988-09-14

    This report presents an evaluation of interconnected high performance workstations. The evaluation specifically addresses the benefits to personnel engaged in Computer Aided Software Engineering (CASE) for the design and development of computer software aided by computer workstations. To narrow the scope of the CASE evaluation to a reasonable size, the class of workstations considered was limited to units having the following minimum capabilities: speed to issue 2 to 3 million instructions per second (Mips), 4 megabytes (MB) of central memory, 140 MB of local disk storage, a monitor with 1024 by 960 graphics resolution, and Ethernet compatibility. In addition, software requirements included a virtual memory implementation of the UNIX operating system, the defacto standard networking Transmission Control Protocol and Internet Protocol (TCP/IP), and the network file system (NFS). Support of selected third-party software, such as the TEMPLATE graphics software, and robust tools for software development were also required. These criteria are justified by the use of workstations for maintenance and support of large mainframe based FORTRAN computer programs. The evaluation concluded that workstations are excellent tools for CASE. 1 ref., 1 fig., 6 tabs.

  2. Optimal lead time for dengue forecast.

    Directory of Open Access Journals (Sweden)

    Yien Ling Hii

    Full Text Available BACKGROUND: A dengue early warning system aims to prevent a dengue outbreak by providing an accurate prediction of a rise in dengue cases and sufficient time to allow timely decisions and preventive measures to be taken by local authorities. This study seeks to identify the optimal lead time for warning of dengue cases in Singapore given the duration required by a local authority to curb an outbreak. METHODOLOGY AND FINDINGS: We developed a Poisson regression model to analyze relative risks of dengue cases as functions of weekly mean temperature and cumulative rainfall with lag times of 1-5 months using spline functions. We examined the duration of vector control and cluster management in dengue clusters > = 10 cases from 2000 to 2010 and used the information as an indicative window of the time required to mitigate an outbreak. Finally, we assessed the gap between forecast and successful control to determine the optimal timing for issuing an early warning in the study area. Our findings show that increasing weekly mean temperature and cumulative rainfall precede risks of increasing dengue cases by 4-20 and 8-20 weeks, respectively. These lag times provided a forecast window of 1-5 months based on the observed weather data. Based on previous vector control operations, the time needed to curb dengue outbreaks ranged from 1-3 months with a median duration of 2 months. Thus, a dengue early warning forecast given 3 months ahead of the onset of a probable epidemic would give local authorities sufficient time to mitigate an outbreak. CONCLUSIONS: Optimal timing of a dengue forecast increases the functional value of an early warning system and enhances cost-effectiveness of vector control operations in response to forecasted risks. We emphasize the importance of considering the forecast-mitigation gaps in respective study areas when developing a dengue forecasting model.

  3. CAD/CAM (Computer Aided Design/Computer Aided Manufacture). A Brief Guide to Materials in the Library of Congress.

    Science.gov (United States)

    Havas, George D.

    This brief guide to materials in the Library of Congress (LC) on computer aided design and/or computer aided manufacturing lists reference materials and other information sources under 13 headings: (1) brief introductions; (2) LC subject headings used for such materials; (3) textbooks; (4) additional titles; (5) glossaries and handbooks; (6)…

  4. Retrofitting a crown to a sleep apnea device by using computer-aided design and computer-aided milling technology.

    Science.gov (United States)

    Biethman, Rick; Land, Martin F; Hruskocy, Heather; Colgin, Bruce

    2014-07-01

    Retrofitting a new crown to an existing dental device is challenging. The continued evolution of computer-aided design and computer-aided manufacturing (CAD/CAM) significantly simplifies the process. This article demonstrates retrofitting a gold crown to an existing sleep apnea device.

  5. The Structural Optimization of Trees

    Science.gov (United States)

    Mattheck, C.; Bethge, K.

    1998-01-01

    Optimization methods are presented for engineering design based on the axiom of uniform stress. The principle of adaptive growth which biological structures use to minimize stress concentrations has been incorporated into a computer-aided optimization (CAO) procedure. Computer-aided optimization offers the advantage of three-dimensional optimization for the purpose of designing more fatigue-resistant components without mathematical sophistication. Another method, called computer-aided internal optimization (CAIO), optimizes the performance of fiber-composite materials by aligning the fiber distribution with the force flow, again mimicking the structure of trees. The lines of force flow, so-called principal stress trajectories, are not subject to shear stresses. Avoiding shear stresses in the technical components can lead to an increase in maximum load capacity. By the use of a new testing device strength distributions in trees can be determined and explained based on a new mechanical wood model.

  6. Microwave processing of a dental ceramic used in computer-aided design/computer-aided manufacturing.

    Science.gov (United States)

    Pendola, Martin; Saha, Subrata

    2015-01-01

    Because of their favorable mechanical properties and natural esthetics, ceramics are widely used in restorative dentistry. The conventional ceramic sintering process required for their use is usually slow, however, and the equipment has an elevated energy consumption. Sintering processes that use microwaves have several advantages compared to regular sintering: shorter processing times, lower energy consumption, and the capacity for volumetric heating. The objective of this study was to test the mechanical properties of a dental ceramic used in computer-aided design/computer-aided manufacturing (CAD/CAM) after the specimens were processed with microwave hybrid sintering. Density, hardness, and bending strength were measured. When ceramic specimens were sintered with microwaves, the processing times were reduced and protocols were simplified. Hardness was improved almost 20% compared to regular sintering, and flexural strength measurements suggested that specimens were approximately 50% stronger than specimens sintered in a conventional system. Microwave hybrid sintering may preserve or improve the mechanical properties of dental ceramics designed for CAD/CAM processing systems, reducing processing and waiting times.

  7. Conceptual framework for the integration of computer-aided design and computer-aided process planning

    Energy Technology Data Exchange (ETDEWEB)

    Li, R.K.

    1986-01-01

    This research presents a conceptual framework for the integration of Computer-Aided Design (CAD) and Computer-Aided Process Planning (CAPP). The conceptual framework resides in an environmental of N CAD systems and M CAPP systems. It consists of three major modules: a generic-part definition data structure, a preprocessor, and a postprocessor. The generic-part definition data structure was developed to serve as a neutral-part definition data representation between CAD and CAPP systems. With this structure, the number of interfacing systems can be reduced to 1 + M systems. The preprocessor, a part feature recognition system, is designed to extract part definition data from an IGES file, evaluates that data, allows inclusion of unsupported data, and finally puts the data into the data structure. The postprocessor was written to convert the data from the data structure to the part input format of a selected CAPP system. A prototype systems that uses IBM's CAD package (CADAM), IGES and United Technologies Research Center's CAPP package (CMPP) was developed to test and prove the concept of this research. The input is a CADAM graphic design file and the outputs are a summary of operations and a tolerance control chart which are ready to be used in the production shops.

  8. Adhesive Bonding to Computer-aided Design/ Computer-aided Manufacturing Esthetic Dental Materials: An Overview.

    Science.gov (United States)

    Awad, Mohamed Moustafa; Alqahtani, H; Al-Mudahi, A; Murayshed, M S; Alrahlah, A; Bhandi, Shilpa H

    2017-07-01

    To review the adhesive bonding to different computer-aided design/computer-aided manufacturing (CAD/CAM) esthetic restorative materials. The use of CAD/CAM esthetic restorative materials has gained popularity in recent years. Several CAD/ CAM esthetic restorative materials are commercially available. Adhesive bonding is a major determinant of success of CAD/ CAM restorations. Review result: An account of the currently available bonding strategies are discussed with their rationale in various CAD/ CAM materials. Different surface treatment methods as well as adhesion promoters can be used to achieve reliable bonding of CAD/CAM restorative materials. Selection of bonding strategy to such material is determined based on its composition. Further evidence is required to evaluate the effect of new surface treatment methods, such as nonthermal atmospheric plasma and self-etching ceramic primer on bonding to different dental ceramics. An understanding of the currently available bonding strategies to CA/CAM materials can help the clinician to select the most indicated system for each category of materials.

  9. On the solution of mixed-integer nonlinear programming models for computer aided molecular design.

    Science.gov (United States)

    Ostrovsky, Guennadi M; Achenie, Luke E K; Sinha, Manish

    2002-11-01

    This paper addresses the efficient solution of computer aided molecular design (CAMD) problems, which have been posed as mixed-integer nonlinear programming models. The models of interest are those in which the number of linear constraints far exceeds the number of nonlinear constraints, and with most variables participating in the nonconvex terms. As a result global optimization methods are needed. A branch-and-bound algorithm (BB) is proposed that is specifically tailored to solving such problems. In a conventional BB algorithm, branching is performed on all the search variables that appear in the nonlinear terms. This translates to a large number of node traversals. To overcome this problem, we have proposed a new strategy for branching on a set of linear branchingfunctions, which depend linearly on the search variables. This leads to a significant reduction in the dimensionality of the search space. The construction of linear underestimators for a class of functions is also presented. The CAMD problem that is considered is the design of optimal solvents to be used as cleaning agents in lithographic printing.

  10. Development and Evaluation of a Computer-Aided Learning (CAL ...

    African Journals Online (AJOL)

    Development and Evaluation of a Computer-Aided Learning (CAL) Package on C++ ... Technology has created a great potential for borderless education. ... packages in the future, thus roviding additional resources for independent learning.

  11. Computer Aided Design Tools for Extreme Environment Electronics Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This project aims to provide Computer Aided Design (CAD) tools for radiation-tolerant, wide-temperature-range digital, analog, mixed-signal, and radio-frequency...

  12. Computer-Aided Qualitative Data Analysis with Word

    Directory of Open Access Journals (Sweden)

    Bruno Nideröst

    2002-05-01

    Full Text Available Despite some fragmentary references in the literature about qualitative methods, it is fairly unknown that Word can be successfully used for computer-aided Qualitative Data Analyses (QDA. Based on several Word standard operations, elementary QDA functions such as sorting data, code-and-retrieve and frequency counts can be realized. Word is particularly interesting for those users who wish to have first experiences with computer-aided analysis before investing time and money in a specialized QDA Program. The well-known standard software could also be an option for those qualitative researchers who usually work with word processing but have certain reservations towards computer-aided analysis. The following article deals with the most important requirements and options of Word for computer-aided QDA. URN: urn:nbn:de:0114-fqs0202225

  13. Computer-aided Translation Technology and Its Applications

    Institute of Scientific and Technical Information of China (English)

    汪美侠; 何大顺

    2014-01-01

    This article begins with a brief analysis of the significance of translation technology in different spheres of modern life, followed by a distinction between machine translation (MT) and computer-aided translation (CAT). It then describes some trans-lation resources and tools and examines the negative and positive aspects of computer-aided translations. Finally it comes to a conclusion that it would be greatly efficient and productive for the translators to acquire the new skills in the translation work-place.

  14. Computer-aided design development transition for IPAD environment

    Science.gov (United States)

    Owens, H. G.; Mock, W. D.; Mitchell, J. C.

    1980-01-01

    The relationship of federally sponsored computer-aided design/computer-aided manufacturing (CAD/CAM) programs to the aircraft life cycle design process, an overview of NAAD'S CAD development program, an evaluation of the CAD design process, a discussion of the current computing environment within which NAAD is developing its CAD system, some of the advantages/disadvantages of the NAAD-IPAD approach, and CAD developments during transition into the IPAD system are discussed.

  15. PLAID- A COMPUTER AIDED DESIGN SYSTEM

    Science.gov (United States)

    Brown, J. W.

    1994-01-01

    PLAID is a three-dimensional Computer Aided Design (CAD) system which enables the user to interactively construct, manipulate, and display sets of highly complex geometric models. PLAID was initially developed by NASA to assist in the design of Space Shuttle crewstation panels, and the detection of payload object collisions. It has evolved into a more general program for convenient use in many engineering applications. Special effort was made to incorporate CAD techniques and features which minimize the users workload in designing and managing PLAID models. PLAID consists of three major modules: the Primitive Object Generator (BUILD), the Composite Object Generator (COG), and the DISPLAY Processor. The BUILD module provides a means of constructing simple geometric objects called primitives. The primitives are created from polygons which are defined either explicitly by vertex coordinates, or graphically by use of terminal crosshairs or a digitizer. Solid objects are constructed by combining, rotating, or translating the polygons. Corner rounding, hole punching, milling, and contouring are special features available in BUILD. The COG module hierarchically organizes and manipulates primitives and other previously defined COG objects to form complex assemblies. The composite object is constructed by applying transformations to simpler objects. The transformations which can be applied are scalings, rotations, and translations. These transformations may be defined explicitly or defined graphically using the interactive COG commands. The DISPLAY module enables the user to view COG assemblies from arbitrary viewpoints (inside or outside the object) both in wireframe and hidden line renderings. The PLAID projection of a three-dimensional object can be either orthographic or with perspective. A conflict analysis option enables detection of spatial conflicts or collisions. DISPLAY provides camera functions to simulate a view of the model through different lenses. Other

  16. A review of computer-aided design/computer-aided manufacture techniques for removable denture fabrication.

    Science.gov (United States)

    Bilgin, Mehmet Selim; Baytaroğlu, Ebru Nur; Erdem, Ali; Dilber, Erhan

    2016-01-01

    The aim of this review was to investigate usage of computer-aided design/computer-aided manufacture (CAD/CAM) such as milling and rapid prototyping (RP) technologies for removable denture fabrication. An electronic search was conducted in the PubMed/MEDLINE, ScienceDirect, Google Scholar, and Web of Science databases. Databases were searched from 1987 to 2014. The search was performed using a variety of keywords including CAD/CAM, complete/partial dentures, RP, rapid manufacturing, digitally designed, milled, computerized, and machined. The identified developments (in chronological order), techniques, advantages, and disadvantages of CAD/CAM and RP for removable denture fabrication are summarized. Using a variety of keywords and aiming to find the topic, 78 publications were initially searched. For the main topic, the abstract of these 78 articles were scanned, and 52 publications were selected for reading in detail. Full-text of these articles was gained and searched in detail. Totally, 40 articles that discussed the techniques, advantages, and disadvantages of CAD/CAM and RP for removable denture fabrication and the articles were incorporated in this review. Totally, 16 of the papers summarized in the table. Following review of all relevant publications, it can be concluded that current innovations and technological developments of CAD/CAM and RP allow the digitally planning and manufacturing of removable dentures from start to finish. As a result according to the literature review CAD/CAM techniques and supportive maxillomandibular relationship transfer devices are growing fast. In the close future, fabricating removable dentures will become medical informatics instead of needing a technical staff and procedures. However the methods have several limitations for now.

  17. [Computer-aided electronic prescribing in Spanish hospitals].

    Science.gov (United States)

    Rubio Fernández, M; Aldaz Francés, R; García Gómez, C; Valladolid Walsh, A

    2005-01-01

    To describe electronic prescribing in a sample of Spanish hospitals and activities derived from its implementation in Hospital Pharmacy Departments, software features and acceptance. A survey that included data related to program implantation and performance in hospitals with diverse characteristics was designed. It was posted at the Sociedad Española de Farmacia Hospitalaria website for a 6-month period and completed by phone. A total of 47 hospitals answered the survey. 13 (27.7%) had electronic prescribing systems, and of these, 8 of them had more than 75% of beds included in the system. In 15 (31.9%) hospitals that did not have it, its implementation was in project in the near future. Software applications used in this new health technology were not homogeneous, while integration of applications that facilitate Pharmaceutical Care tasks was infrequent. In 61.5% of the hospitals with electronic prescribing, transcription used to be the pharmacist s task. In 92.3% of these hospitals, order validation is currently carried out by pharmacists. The degree of satisfaction with the system was rated as good or very good by 92.3% of pharmacists. Computer-aided electronic prescribing appears to be a helpful tool for restructuring Department organization and investing time in new activities. A more ambitious and effective approach to clinical activities will therefore be possible. System optimization requires taking into account factors such as worker time investment, since new activities will be developed, along with the need for training courses.

  18. A handheld computer-aided diagnosis system and simulated analysis

    Science.gov (United States)

    Su, Mingjian; Zhang, Xuejun; Liu, Brent; Su, Kening; Louie, Ryan

    2016-03-01

    This paper describes a Computer Aided Diagnosis (CAD) system based on cellphone and distributed cluster. One of the bottlenecks in building a CAD system for clinical practice is the storage and process of mass pathology samples freely among different devices, and normal pattern matching algorithm on large scale image set is very time consuming. Distributed computation on cluster has demonstrated the ability to relieve this bottleneck. We develop a system enabling the user to compare the mass image to a dataset with feature table by sending datasets to Generic Data Handler Module in Hadoop, where the pattern recognition is undertaken for the detection of skin diseases. A single and combination retrieval algorithm to data pipeline base on Map Reduce framework is used in our system in order to make optimal choice between recognition accuracy and system cost. The profile of lesion area is drawn by doctors manually on the screen, and then uploads this pattern to the server. In our evaluation experiment, an accuracy of 75% diagnosis hit rate is obtained by testing 100 patients with skin illness. Our system has the potential help in building a novel medical image dataset by collecting large amounts of gold standard during medical diagnosis. Once the project is online, the participants are free to join and eventually an abundant sample dataset will soon be gathered enough for learning. These results demonstrate our technology is very promising and expected to be used in clinical practice.

  19. A Robust and Fast System for CTC Computer-Aided Detection of Colorectal Lesions

    OpenAIRE

    2010-01-01

    We present a complete, end-to-end computer-aided detection (CAD) system for identifying lesions in the colon, imaged with computed tomography (CT). This system includes facilities for colon segmentation, candidate generation, feature analysis, and classification. The algorithms have been designed to offer robust performance to variation in image data and patient preparation. By utilizing efficient 2D and 3D processing, software optimizations, multi-threading, feature selection, and an optimiz...

  20. Computer-aided interpretation approach for optical tomographic images

    Science.gov (United States)

    Klose, Christian D.; Klose, Alexander D.; Netz, Uwe J.; Scheel, Alexander K.; Beuthan, Jürgen; Hielscher, Andreas H.

    2010-11-01

    A computer-aided interpretation approach is proposed to detect rheumatic arthritis (RA) in human finger joints using optical tomographic images. The image interpretation method employs a classification algorithm that makes use of a so-called self-organizing mapping scheme to classify fingers as either affected or unaffected by RA. Unlike in previous studies, this allows for combining multiple image features, such as minimum and maximum values of the absorption coefficient for identifying affected and not affected joints. Classification performances obtained by the proposed method were evaluated in terms of sensitivity, specificity, Youden index, and mutual information. Different methods (i.e., clinical diagnostics, ultrasound imaging, magnet resonance imaging, and inspection of optical tomographic images), were used to produce ground truth benchmarks to determine the performance of image interpretations. Using data from 100 finger joints, findings suggest that some parameter combinations lead to higher sensitivities, while others to higher specificities when compared to single parameter classifications employed in previous studies. Maximum performances are reached when combining the minimum/maximum ratio of the absorption coefficient and image variance. In this case, sensitivities and specificities over 0.9 can be achieved. These values are much higher than values obtained when only single parameter classifications were used, where sensitivities and specificities remained well below 0.8.

  1. Computer-aided simulation of the heat treatment

    Energy Technology Data Exchange (ETDEWEB)

    Arola, R.; Martikainen, H.; Virta, J. [Technical Research Centre of Finland, Espoo (Finland). Metallurgy Lab.

    1993-12-31

    Computer-aided simulation of the heat treatment of components and charges is examined. Existing programs for the simulation of heat treatment are reviewed. Test simulations including calculation of temperature, phase composition and stresses and strains during heating and cooling are performed with selected programs. The results of the simulations are compared with the results of heat treating experiments. Heat transfer during heating-up varies considerably between different treatments, components of the charge and surfaces of the component. Therefore, heat transfer data defined on the basis of the measurements has to be used in exact simulation instead of literature data. According to the simulation results non-uniform temperature distribution, plastic straining and residual stresses after heating can be formed in an AISI 316 bar heated up at the edge of a charge in a pit furnace. Permanent bending of these bars as a result of heating is not observed. In the oil quenching of a 42CrMo4 cylinder, where martensite and bainite are formed in austenite decomposition, the simulation results (especially amounts of phases and residual stresses) are crucially dependent on the TTT-diagram describing the kinetics of the phase transformations. Several TTT-diagrams for the steel grade are found, leading to different simulation results

  2. Role of computer-aided drug design in modern drug discovery.

    Science.gov (United States)

    Macalino, Stephani Joy Y; Gosu, Vijayakumar; Hong, Sunhye; Choi, Sun

    2015-09-01

    Drug discovery utilizes chemical biology and computational drug design approaches for the efficient identification and optimization of lead compounds. Chemical biology is mostly involved in the elucidation of the biological function of a target and the mechanism of action of a chemical modulator. On the other hand, computer-aided drug design makes use of the structural knowledge of either the target (structure-based) or known ligands with bioactivity (ligand-based) to facilitate the determination of promising candidate drugs. Various virtual screening techniques are now being used by both pharmaceutical companies and academic research groups to reduce the cost and time required for the discovery of a potent drug. Despite the rapid advances in these methods, continuous improvements are critical for future drug discovery tools. Advantages presented by structure-based and ligand-based drug design suggest that their complementary use, as well as their integration with experimental routines, has a powerful impact on rational drug design. In this article, we give an overview of the current computational drug design and their application in integrated rational drug development to aid in the progress of drug discovery research.

  3. Computer-Aided Chemical Product Design Framework: Design of High Performance and Environmentally Friendly Refrigerants

    DEFF Research Database (Denmark)

    Cignitti, Stefano; Zhang, Lei; Gani, Rafiqul

    a driving force for the industry to continuously seek novel refrigerants as current refrigerants risk phasing out due to environmental regulations. This trend has been seen since the Kyoto Protocol in 1997 and recently from the EU regulations from 2014, which will restrict the use of some known refrigerants...... properties and needs should carefully be selected for a given heat pump cycle to ensure that an optimum refrigerant is found? How can cycle performance and environmental criteria be integrated at the product design stage and not in post-design analysis? Computer-aided product design methods enable...... the possibility of designing novel molecules, mixtures and blends, such as refrigerants through a systematic framework (Cignitti et al., 2015; Yunus et al., 2014). In this presentation a computer-aided framework is presented for chemical product design through mathematical optimization. Here, molecules, mixtures...

  4. Application of computer-aided multi-scale modelling framework – Aerosol case study

    DEFF Research Database (Denmark)

    Heitzig, Martina; Sin, Gürkan; Glarborg, Peter

    -aided methods provide. The key prerequisite of computer-aided product-process engineering is however the availability of models of different types, forms and application modes. The development of the models required for the systems under investigation tends to be a challenging and time-consuming task involving...... numerous steps, expert skills and different modelling tools. This motivates the development of a computer-aided modelling framework that supports the user during model development, documentation, analysis, identification, application and re-use with the goal to increase the efficiency of the modelling...... generation, optimal equation ordering, eigenvalue analysis. Once the models have been constructed and analysed the modelling framework incorporates 3 application work-flows for: identification, simulation and design. For these application work-flows different solvers that can solve a large range of different...

  5. Freedom and necessity in computer aided composition: A thinking framework and its application

    Science.gov (United States)

    Kretz, Johannes

    This paper presents some of the author's experiences with computer aided composition (CAC): the modeling of physical movements is used to obtain plausible musical gestures in interaction with constraint programming (rule based expert systems) in order to achieve precisely structured, consistent musical material with strong inner logic and syntax in pitch material. The "Constraints Engine" by Michael Laurson implemented in OpenMusic (IRCAM) or PWGL (Sibelius Academy) can be used to set up an interactive framework for composition, which offers a balance of freedom (allowing chance operations and arbitrary decisions of the composer) and necessity (through strict rules as well as through criteria for optimization). Computer Aided Composition is moving far beyond being "algorithmic" or "mechanical". This paper proposes an approach based on evolutionary epistemology (by the Austrian biologist and philosopher Rupert Riedl). The aim is a holistic synthesis of artistic freedom and coherent structures similar to the grown order of nature.

  6. Computer-Aided Fabrication System Implementation

    Science.gov (United States)

    1987-03-31

    Sutardja, Y. Shacham-Diamand, and W. Oldham, "Simulation of Stress Effects on the Reaction Kinectics and Oxidant Diffusion in Silicon Oxidation...a2(t) (6) Suppose the constraints for uj and V2 depend on some random processes (e.g. the machine state). We must determine Ui and U2 based on...19) If J(x, a, t) is known, then the optimal routing and scheduling policy y satisfies m_ yeü{. 3J, in jT-fy’ + y1 1 + £-( v2 + y2 1 (20

  7. Mathematical modelling in the computer-aided process planning

    Science.gov (United States)

    Mitin, S.; Bochkarev, P.

    2016-04-01

    This paper presents new approaches to organization of manufacturing preparation and mathematical models related to development of the computer-aided multi product process planning (CAMPP) system. CAMPP system has some peculiarities compared to the existing computer-aided process planning (CAPP) systems: fully formalized developing of the machining operations; a capacity to create and to formalize the interrelationships among design, process planning and process implementation; procedures for consideration of the real manufacturing conditions. The paper describes the structure of the CAMPP system and shows the mathematical models and methods to formalize the design procedures.

  8. Integrated computer-aided retinal photocoagulation system

    Science.gov (United States)

    Barrett, Steven F.; Wright, Cameron H. G.; Oberg, Erik D.; Rockwell, Benjamin A.; Cain, Clarence P.; Jerath, Maya R.; Rylander, Henry G., III; Welch, Ashley J.

    1996-05-01

    Successful retinal tracking subsystem testing results in vivo on rhesus monkeys using an argon continuous wave laser and an ultra-short pulse laser are presented. Progress on developing an integrated robotic retinal laser surgery system is also presented. Several interesting areas of study have developed: (1) 'doughnut' shaped lesions that occur under certain combinations of laser power, spot size, and irradiation time complicating measurements of central lesion reflectance, (2) the optimal retinal field of view to achieve simultaneous tracking and lesion parameter control, and (3) a fully digital versus a hybrid analog/digital tracker using confocal reflectometry integrated system implementation. These areas are investigated in detail in this paper. The hybrid system warrants a separate presentation and appears in another paper at this conference.

  9. Computer-aided forensics: metal object detection.

    Science.gov (United States)

    Kelliher, Timothy; Leue, Bill; Lorensen, Bill; Lauric, Alexandra

    2006-01-01

    Recently, forensic investigators1 have started using diagnostic radiology devices (MRI, CT) to acquire image data from cadavers. This new technology, called the virtual autopsy, has the potential to provide a low cost, non-invasive alternative or supplement to conventional autopsies. New image processing techniques are being developed to highlight forensically relevant information in the images. One such technique is the detection and characterization of metal objects embedded in the cadaver. Analysis of this information across a population with similar causes of death can lead to developing improved safety and protection devices with a corresponding reduction in deaths.

  10. Computer-aided design of tension structures

    OpenAIRE

    Ong, C.F.

    1992-01-01

    This thesis consists of three parts. Part I (chapters 1-4) gives a review and description of the basis for the numerical modelling of tension structures. The discussion in Part I leads to the conclusion of a need for an interactive design procedure for tension structures which is the subject under consideration in Part II (chapters 5-7). In the design of tension structures, an area which requires special attention is the dynamic response often initiated by the action of a natural wind. In Par...

  11. Optimization of propafenone analogues as antimalarial leads.

    Science.gov (United States)

    Lowes, David J; Guiguemde, W Armand; Connelly, Michele C; Zhu, Fangyi; Sigal, Martina S; Clark, Julie A; Lemoff, Andrew S; Derisi, Joseph L; Wilson, Emily B; Guy, R Kiplin

    2011-11-10

    Propafenone, a class Ic antiarrythmic drug, inhibits growth of cultured Plasmodium falciparum. While the drug's potency is significant, further development of propafenone as an antimalarial would require divorcing the antimalarial and cardiac activities as well as improving the pharmacokinetic profile of the drug. A small array of propafenone analogues was designed and synthesized to address the cardiac ion channel and PK liabilities. Testing of this array revealed potent inhibitors of the 3D7 (drug sensitive) and K1 (drug resistant) strains of P. falciparum that possessed significantly reduced ion channel effects and improved metabolic stability. Propafenone analogues are unusual among antimalarial leads in that they are more potent against the multidrug resistant K1 strain of P. falciparum compared to the 3D7 strain.

  12. A critically appraised topic review of computer-aided design/computer-aided machining of removable partial denture frameworks.

    Science.gov (United States)

    Lang, Lisa A; Tulunoglu, Ibrahim

    2014-01-01

    A critically appraised topic (CAT) review is presented about the use of computer-aided design (CAD)/computer-aided machining (CAM) removable partial denture (RPD) frameworks. A systematic search of the literature supporting CAD/CAM RPD systems revealed no randomized clinical trials, hence the CAT review was performed. A PubMed search yielded 9 articles meeting the inclusion criteria. Each article was characterized by study design and level of evidence. No clinical outcomes research has been published on the use of CAD/CAM RPDs. Low levels of evidence were found in the available literature. Clinical research studies are needed to determine the efficacy of this treatment modality.

  13. Test Sensitivity in the Computer-Aided Detection of Breast Cancer from Clinical Mammographic Screening: a Meta-analysis

    CERN Document Server

    Levman, Jacob

    2013-01-01

    Objectives: To assess evaluative methodologies for comparative measurements of test sensitivity in clinical mammographic screening trials of computer-aided detection (CAD) technologies. Materials and Methods: This meta-analysis was performed by analytically reviewing the relevant literature on the clinical application of computer-aided detection (CAD) technologies as part of a breast cancer screening program based on x-ray mammography. Each clinical study's method for measuring the CAD system's improvement in test sensitivity is examined in this meta-analysis. The impact of the chosen sensitivity measurement on the study's conclusions are analyzed. Results: This meta-analysis demonstrates that some studies have inappropriately compared sensitivity measurements between control groups and CAD enabled groups. The inappropriate comparison of control groups and CAD enabled groups can lead to an underestimation of the benefits of the clinical application of computer-aided detection technologies. Conclusions: The po...

  14. Helping Alleviate Statistical Anxiety with Computer Aided Statistical Classes

    Science.gov (United States)

    Stickels, John W.; Dobbs, Rhonda R.

    2007-01-01

    This study, Helping Alleviate Statistical Anxiety with Computer Aided Statistics Classes, investigated whether undergraduate students' anxiety about statistics changed when statistics is taught using computers compared to the traditional method. Two groups of students were questioned concerning their anxiety about statistics. One group was taught…

  15. Computer-aided modelling template: Concept and application

    DEFF Research Database (Denmark)

    Fedorova, Marina; Sin, Gürkan; Gani, Rafiqul

    2015-01-01

    decomposition technique which identifies generic steps and workflow involved, the computer-aided template concept has been developed. This concept is implemented as a software tool, which provides a user-friendly interface for following the workflow steps and guidance through the steps providing additional...

  16. Computer-Aided Template for Model Reuse, Development and Maintenance

    DEFF Research Database (Denmark)

    Fedorova, Marina; Sin, Gürkan; Gani, Rafiqul

    2014-01-01

    A template-based approach for model development is presented in this work. Based on a model decomposition technique, the computer-aided template concept has been developed. This concept is implemented as a software tool , which provides a user-friendly interface for following the workflow steps, ...

  17. The Journal of Computer- Aided Molecular Design: a bibliometric note

    Science.gov (United States)

    Willett, Peter

    2012-01-01

    Summarizes the articles in, and the citations to, volumes 2-24 of the Journal of Computer- Aided Molecular Design. The citations to the journal come from almost 2000 different sources that span a very wide range of academic subjects, with the most heavily cited articles being descriptions of software systems and of computational methods.

  18. De novo computer-aided design of novel antiviral agents.

    Science.gov (United States)

    Massarotti, Alberto; Coluccia, Antonio; Sorba, Giovanni; Silvestri, Romano; Brancale, Andrea

    2012-01-01

    Computer-aided drug design techniques have become an integral part of the drug discovery process. In particular, de novo methodologies can be useful to identify putative ligands for a specific target relying only on the structural information of the target itself. Here we discuss the basic de novo approaches available and their application in antiviral drug design.:

  19. A Computer Aided System for Simulating Weld Metal Solidification Crack

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    A computer-aided system for simulating weld solidification crack has been developed by which a welding engineer can carry out the welding solidification crack simulation on the basis of a commercial finite element analysis software package. Its main functions include calculating the heat generations of the moving arc, mesh generation, calculating stress-strain distributions with element rebirth technique.

  20. Computer-Aided Characterization and Diagnosis of Diffuse Liver Diseases Based on Ultrasound Imaging: A Review.

    Science.gov (United States)

    Bharti, Puja; Mittal, Deepti; Ananthasivan, Rupa

    2016-04-19

    Diffuse liver diseases, such as hepatitis, fatty liver, and cirrhosis, are becoming a leading cause of fatality and disability all over the world. Early detection and diagnosis of these diseases is extremely important to save lives and improve effectiveness of treatment. Ultrasound imaging, a noninvasive diagnostic technique, is the most commonly used modality for examining liver abnormalities. However, the accuracy of ultrasound-based diagnosis depends highly on expertise of radiologists. Computer-aided diagnosis systems based on ultrasound imaging assist in fast diagnosis, provide a reliable "second opinion" for experts, and act as an effective tool to measure response of treatment on patients undergoing clinical trials. In this review, we first describe appearance of liver abnormalities in ultrasound images and state the practical issues encountered in characterization of diffuse liver diseases that can be addressed by software algorithms. We then discuss computer-aided diagnosis in general with features and classifiers relevant to diffuse liver diseases. In later sections of this paper, we review the published studies and describe the key findings of those studies. A concise tabular summary comparing image database, features extraction, feature selection, and classification algorithms presented in the published studies is also exhibited. Finally, we conclude with a summary of key findings and directions for further improvements in the areas of accuracy and objectiveness of computer-aided diagnosis. © The Author(s) 2016.

  1. Computer-Aided Targeting of the PI3K/Akt/mTOR Pathway: Toxicity Reduction and Therapeutic Opportunities

    Directory of Open Access Journals (Sweden)

    Tan Li

    2014-10-01

    Full Text Available The PI3K/Akt/mTOR pathway plays an essential role in a wide range of biological functions, including metabolism, macromolecular synthesis, cell growth, proliferation and survival. Its versatility, however, makes it a conspicuous target of many pathogens; and the consequential deregulations of this pathway often lead to complications, such as tumorigenesis, type 2 diabetes and cardiovascular diseases. Molecular targeted therapy, aimed at modulating the deregulated pathway, holds great promise for controlling these diseases, though side effects may be inevitable, given the ubiquity of the pathway in cell functions. Here, we review a variety of factors found to modulate the PI3K/Akt/mTOR pathway, including gene mutations, certain metabolites, inflammatory factors, chemical toxicants, drugs found to rectify the pathway, as well as viruses that hijack the pathway for their own synthetic purposes. Furthermore, this evidence of PI3K/Akt/mTOR pathway alteration and related pathogenesis has inspired the exploration of computer-aided targeting of this pathway to optimize therapeutic strategies. Herein, we discuss several possible options, using computer-aided targeting, to reduce the toxicity of molecularly-targeted therapy, including mathematical modeling, to reveal system-level control mechanisms and to confer a low-dosage combination therapy, the potential of PP2A as a therapeutic target, the formulation of parameters to identify patients who would most benefit from specific targeted therapies and molecular dynamics simulations and docking studies to discover drugs that are isoform specific or mutation selective so as to avoid undesired broad inhibitions. We hope this review will stimulate novel ideas for pharmaceutical discovery and deepen our understanding of curability and toxicity by targeting the PI3K/Akt/mTOR pathway.

  2. Computer-Aided Design and Computer-Aided Manufacturing Hydroxyapatite/Epoxide Acrylate Maleic Compound Construction for Craniomaxillofacial Bone Defects.

    Science.gov (United States)

    Zhang, Lei; Shen, Shunyao; Yu, Hongbo; Shen, Steve Guofang; Wang, Xudong

    2015-07-01

    The aim of this study was to investigate the use of computer-aided design and computer-aided manufacturing hydroxyapatite (HA)/epoxide acrylate maleic (EAM) compound construction artificial implants for craniomaxillofacial bone defects. Computed tomography, computer-aided design/computer-aided manufacturing and three-dimensional reconstruction, as well as rapid prototyping were performed in 12 patients between 2008 and 2013. The customized HA/EAM compound artificial implants were manufactured through selective laser sintering using a rapid prototyping machine into the exact geometric shapes of the defect. The HA/EAM compound artificial implants were then implanted during surgical reconstruction. Color-coded superimpositions demonstrated the discrepancy between the virtual plan and achieved results using Geomagic Studio. As a result, the HA/EAM compound artificial bone implants were perfectly matched with the facial areas that needed reconstruction. The postoperative aesthetic and functional results were satisfactory. The color-coded superimpositions demonstrated good consistency between the virtual plan and achieved results. The three-dimensional maximum deviation is 2.12 ± 0.65  mm and the three-dimensional mean deviation is 0.27 ± 0.07  mm. No facial nerve weakness or pain was observed at the follow-up examinations. Only 1 implant had to be removed 2 months after the surgery owing to severe local infection. No other complication was noted during the follow-up period. In conclusion, computer-aided, individually fabricated HA/EAM compound construction artificial implant was a good craniomaxillofacial surgical technique that yielded improved aesthetic results and functional recovery after reconstruction.

  3. Tailor-made Design of Chemical Blends using Decomposition-based Computer-aided Approach

    DEFF Research Database (Denmark)

    Yunus, Nor Alafiza; Manan, Zainuddin Abd.; Gernaey, Krist

    methodology for blended liquid products that identifies a set of feasible chemical blends. The blend design problem is formulated as a nonlinear programming (NLP) model where the objective is to find the optimal blended gasoline or diesel product subject to blend chemicals and their compositions, a set...... to a specified priority. Finally, a short list of candidates, ordered in terms of specified performance criteria, is produced for final testing and selection. This systematic and computer-aided approach is illustrated through a case study involving the design of blends of gasoline with oxygenates from biomass...

  4. Design of tailor-made chemical blend using a decomposition-based computer-aided approach

    DEFF Research Database (Denmark)

    Yunus, Nor Alafiza; Gernaey, Krist; Manan, Z.A.

    2011-01-01

    methodology for blended liquid products that identifies a set of feasible chemical blends. The blend design problem is formulated as a Mixed Integer Nonlinear Programming (MINLP) model where the objective is to find the optimal blended gasoline or diesel product subject to types of chemicals....... The application of this systematic and computer-aided approach is illustrated through a case study involving the design of blends of gasoline with oxygenated compounds resulting from degradation and fermentation of biomass for use in internal combustion engines. Emphasis is given here on the concepts used...

  5. Computer Aided Design and Analysis of a 2-4 GHz Broadband Balanced Microstrip Amplifier

    OpenAIRE

    S. H. Ibrahim

    2012-01-01

    In this paper, a computer-aided design and analysis of a 2-4 GHz broadband balanced microstrip amplifier using a full computer simulation program developed by the author and others is presented. A short and efficient CAD procedure for broadband amplifier design is introduced. The first step is to design an initial narrow-band high gain microstrip amplifier at 3-GHz central frequency. The second step is to optimize the initial lengths and widths of the input and output microstrip-matching circ...

  6. Research on Computer Aided Innovation Model of Weapon Equipment Requirement Demonstration

    Science.gov (United States)

    Li, Yong; Guo, Qisheng; Wang, Rui; Li, Liang

    Firstly, in order to overcome the shortcoming of using only AD or TRIZ solely, and solve the problems currently existed in weapon equipment requirement demonstration, the paper construct the method system of weapon equipment requirement demonstration combining QFD, AD, TRIZ, FA. Then, we construct a CAI model frame of weapon equipment requirement demonstration, which include requirement decomposed model, requirement mapping model and requirement plan optimization model. Finally, we construct the computer aided innovation model of weapon equipment requirement demonstration, and developed CAI software of equipment requirement demonstration.

  7. A computer-aided method for postproduction tuning of HTS filters

    Energy Technology Data Exchange (ETDEWEB)

    Zuo Tao; Fang Lan; Yan Shaolin; Zhao Xinjie; Zhou Tiege; You Shitou; Ma Weigang; Yue Hongwei; Xie Qinglian [Department of Electronics, Nankai University, Tianjin 300071 (China)

    2007-12-15

    The empirical tuning of high temperature superconducting (HTS) filters is usually time-consuming and expensive. A computer-aided tuning method is presented in this paper. By means of optimization, the method diagnoses detuning of individual resonators quantitatively in the tuning process, and then by using neural network models the method is able to give the operator a decision on how much the corresponding tuning screws should be tuned. So, compared with the empirical tuning method, this method can be used to tune the HTS filters accurately with less time and cost.

  8. The Application of Computer-Aided Discovery to Spacecraft Site Selection

    Science.gov (United States)

    Pankratius, V.; Blair, D. M.; Gowanlock, M.; Herring, T.

    2015-12-01

    The selection of landing and exploration sites for interplanetary robotic or human missions is a complex task. Historically it has been labor-intensive, with large groups of scientists manually interpreting a planetary surface across a variety of datasets to identify potential sites based on science and engineering constraints. This search process can be lengthy, and excellent sites may get overlooked when the aggregate value of site selection criteria is non-obvious or non-intuitive. As planetary data collection leads to Big Data repositories and a growing set of selection criteria, scientists will face a combinatorial search space explosion that requires scalable, automated assistance. We are currently exploring more general computer-aided discovery techniques in the context of planetary surface deformation phenomena that can lend themselves to application in the landing site search problem. In particular, we are developing a general software framework that addresses key difficulties: characterizing a given phenomenon or site based on data gathered from multiple instruments (e.g. radar interferometry, gravity, thermal maps, or GPS time series), and examining a variety of possible workflows whose individual configurations are optimized to isolate different features. The framework allows algorithmic pipelines and hypothesized models to be perturbed or permuted automatically within well-defined bounds established by the scientist. For example, even simple choices for outlier and noise handling or data interpolation can drastically affect the detectability of certain features. These techniques aim to automate repetitive tasks that scientists routinely perform in exploratory analysis, and make them more efficient and scalable by executing them in parallel in the cloud. We also explore ways in which machine learning can be combined with human feedback to prune the search space and converge to desirable results. Acknowledgements: We acknowledge support from NASA AIST

  9. Computer Aided Design System for Developing Musical Fountain Programs

    Institute of Scientific and Technical Information of China (English)

    刘丹; 张乃尧; 朱汉城

    2003-01-01

    A computer aided design system for developing musical fountain programs was developed with multiple functions such as intelligent design, 3-D animation, manual modification and synchronized motion to make the development process more efficient. The system first analyzed the music form and sentiment using many basic features of the music to select a basic fountain program. Then, this program is simulated with 3-D animation and modified manually to achieve the desired results. Finally, the program is transformed to a computer control program to control the musical fountain in time with the music. A prototype system for the musical fountain was also developed. It was tested with many styles of music and users were quite satisfied with its performance. By integrating various functions, the proposed computer aided design system for developing musical fountain programs greatly simplified the design of the musical fountain programs.

  10. Method of Computer-aided Instruction in Situation Control Systems

    Directory of Open Access Journals (Sweden)

    Anatoliy O. Kargin

    2013-01-01

    Full Text Available The article considers the problem of computer-aided instruction in context-chain motivated situation control system of the complex technical system behavior. The conceptual and formal models of situation control with practical instruction are considered. Acquisition of new behavior knowledge is presented as structural changes in system memory in the form of situational agent set. Model and method of computer-aided instruction represent formalization, based on the nondistinct theories by physiologists and cognitive psychologists.The formal instruction model describes situation and reaction formation and dependence on different parameters, effecting education, such as the reinforcement value, time between the stimulus, action and the reinforcement. The change of the contextual link between situational elements when using is formalized.The examples and results of computer instruction experiments of the robot device “LEGO MINDSTORMS NXT”, equipped with ultrasonic distance, touch, light sensors.

  11. Microstereolithography-based computer-aided manufacturing for tissue engineering.

    Science.gov (United States)

    Cho, Dong-Woo; Kang, Hyun-Wook

    2012-01-01

    Various solid freeform fabrication technologies have been introduced for constructing three-dimensional (3-D) freeform structures. Of these, microstereolithography (MSTL) technology performs the best in 3-D space because it not only has high resolution, but also fast fabrication speed. Using this technology, 3-D structures with mesoscale size and microscale resolution are achievable. Many researchers have been trying to apply this technology to tissue engineering to construct medically applicable scaffolds, which require a 3-D shape that fits a defect with a mesoscale size and microscale inner architecture for efficient regeneration of artificial tissue. This chapter introduces the principles of MSTL technology and representative systems. It includes fabrication and computer-aided design/computer-aided manufacturing (CAD/CAM) processes to show the automation process by which measurements from medical images are used to fabricate the required 3-D shape. Then, various tissue engineering applications based on MSTL are summarized.

  12. Computer-Aided Numerical Inversion of Laplace Transform

    OpenAIRE

    Umesh Kumar

    2000-01-01

    This paper explores the technique for the computer aided numerical inversion of Laplace transform. The inversion technique is based on the properties of a family of three parameter exponential probability density functions. The only limitation in the technique is the word length of the computer being used. The Laplace transform has been used extensively in the frequency domain solution of linear, lumped time invariant networks but its application to the time domain has been limited, mainly be...

  13. Information and computer-aided system for structural materials

    Energy Technology Data Exchange (ETDEWEB)

    Nekrashevitch, Yu.G.; Nizametdinov, Sh.U.; Polkovnikov, A.V.; Rumjantzev, V.P.; Surina, O.N. (Engineering Physics Inst., Moscow (Russia)); Kalinin, G.M.; Sidorenkov, A.V.; Strebkov, Yu.S. (Research and Development Inst. of Power Engineering, Moscow (Russia))

    1992-09-01

    An information and computer-aided system for structural materials data has been developed to provide data for the fusion and fission reactor system design. It is designed for designers, industrial engineers, and material science specialists and provides a friendly interface in an interactive mode. The database for structural materials contains the master files: Chemical composition, physical, mechanical, corrosion, technological properties, regulatory and technical documentation. The system is implemented on a PC/AT running the PS /2 operating system. (orig.).

  14. Computer-aided design and computer science technology

    Science.gov (United States)

    Fulton, R. E.; Voigt, S. J.

    1976-01-01

    A description is presented of computer-aided design requirements and the resulting computer science advances needed to support aerospace design. The aerospace design environment is examined, taking into account problems of data handling and aspects of computer hardware and software. The interactive terminal is normally the primary interface between the computer system and the engineering designer. Attention is given to user aids, interactive design, interactive computations, the characteristics of design information, data management requirements, hardware advancements, and computer science developments.

  15. An Integrated Computer-Aided Approach for Environmental Studies

    DEFF Research Database (Denmark)

    Gani, Rafiqul; Chen, Fei; Jaksland, Cecilia;

    1997-01-01

    A general framework for an integrated computer-aided approach to solve process design, control, and environmental problems simultaneously is presented. Physicochemical properties and their relationships to the molecular structure play an important role in the proposed integrated approach. The scope...... and applicability of the integrated approach is highlighted through examples involving estimation of properties and environmental pollution prevention. The importance of mixture effects on some environmentally important properties is also demonstrated....

  16. Contributions on Computer Aided Manufacturing of Drill-Jig Bushings

    Directory of Open Access Journals (Sweden)

    Vasile Cojocaru

    2009-01-01

    Full Text Available The paper presents the steps for computer aided manufacturing (CAMof the bushings technological class parts: design of the part in CADsoftware; generation of the parametrical link with MSExcel files; extract of the useful information for the technological design (mass, volume, surfaces; setting of the CNC lathe and necessary tools; programming of the CNC code for manufacturing. Given the large variety of the bushingsshapes and dimensions, the application focused on the jig bushings used in drilling processes.

  17. Peer Feedback in Computer Aided College English Writing Instruction

    OpenAIRE

    Ma Zhuo

    2016-01-01

    This study is to examine the acceptability of peer feedback in computer aided college English writing instruction. For the whole writing procedure, subjects in language labs were to take preparation, writing and evaluation stages, undergoing three editions suggested by peer feedbacks. For the first time reading, peers would comment on such general scale as subject and content of drafts, and the second focuses on specific items, for example the morphological, lexical and syntactical aspects, e...

  18. CADEE: Computer-Aided Directed Evolution of Enzymes

    Science.gov (United States)

    Amrein, Beat Anton; Steffen-Munsberg, Fabian; Szeler, Ireneusz; Purg, Miha; Kamerlin, Shina Caroline Lynn

    2017-01-01

    The tremendous interest in enzymes as biocatalysts has led to extensive work in enzyme engineering, as well as associated methodology development. Here, a new framework for computer-aided directed evolution of enzymes (CADEE) is presented which allows a drastic reduction in the time necessary to prepare and analyze in silico semi-automated directed evolution of enzymes. A pedagogical example of the application of CADEE to a real biological system is also presented in order to illustrate the CADEE workflow. PMID:28250941

  19. Some new algorithms for computer aided assembly planning

    OpenAIRE

    Kunica, Zoran; Vranješ, Božo; Hrman, Miljenko

    2015-01-01

    The paper depicts some of the improved and newly implemented algorithms of the computer aided design (CAD) based system for the plan generation of automatic assembly (GPAS), relating to definitions of assembly sequence and paths, space structuring (layout) of the assembly process for bench assembly product orientation, connectivity, and treatment of identical parts in a product. In the approach, the parts of which are presented in the paper, the mechanical product to be assembled is, initiall...

  20. Technology transfer of the Computer-Aided Prototyping System (CAPS)

    OpenAIRE

    Cooke, Robert P.

    1996-01-01

    The inability of the Department of Defense (DOD) to accurately and completely specify requirements for hard real-time software systems has resulted in poor productivity, schedule overruns, and software that is unmaintainable and unreliable. The Computer-Aided Prototyping System (CAPS) provides a capability to quickly develop functional prototypes to verify feasibility of system requirements early in the software development process. It was built to help program managers and software engineers...

  1. Correction of facial and mandibular asymmetry using a computer aided design/computer aided manufacturing prefabricated titanium implant.

    Science.gov (United States)

    Watson, Jason; Hatamleh, Muhanad; Alwahadni, Ahed; Srinivasan, Dilip

    2014-05-01

    Patients with significant craniofacial asymmetry may have functional problems associated with their occlusion and aesthetic concerns related to the imbalance in soft and hard tissue profiles. This report details a case of facial asymmetry secondary to left mandible angle deficiency due to undergoing previous radiotherapy. We describe the correction of the bony deformity using computer aided design/computer aided manufacturing custom-made titanium onlay using novel direct metal laser sintering. The direct metal laser sintering onlay proved a very accurate operative fit and showed a good aesthetic correction of the bony defect with no reported complications postoperatively. It is a useful low-morbidity technique, and there is no resorption or associated donor-site complications.

  2. Curves and surfaces for computer-aided geometric design a practical guide

    CERN Document Server

    Farin, Gerald

    1992-01-01

    A leading expert in CAGD, Gerald Farin covers the representation, manipulation, and evaluation of geometric shapes in this the Third Edition of Curves and Surfaces for Computer Aided Geometric Design. The book offers an introduction to the field that emphasizes Bernstein-Bezier methods and presents subjects in an informal, readable style, making this an ideal text for an introductory course at the advanced undergraduate or graduate level.The Third Edition includes a new chapter on Topology, offers new exercises and sections within most chapters, combines the material on Geometric Continuity i

  3. Research on the Procedure for Computer-Aided Pattern Design of Uygur's Flowered Hats

    OpenAIRE

    Shuxian Liu; Xiaohua Li

    2013-01-01

    Xinjiang Uygur’s flowered hats is famous all over the world, it leads the world of headwear of variou nationalities within China by the variety of styles, the various ways of how to emroider pattern design and exquisite manufacture. It is unusual even in national costumes art of the world. The poupose of this study is to analyze Uygur's headwear, study the rules of Uygur's headwear pattern, analyze the characteristic of the basic pattern, research on the procedure for computer-aided pattern d...

  4. Methodology for Benefit Analysis of CAD/CAM (Computer-Aided Design/Computer-Aided Manufacturing) in USN Shipyards.

    Science.gov (United States)

    1984-03-01

    benefits of CAD/CAR and of the next generation technology, CIDER . The CADOS study (Ref. 13] offers a method to measure the intangibles of CAD/CAR...methodology that measures both tangible and intangible benefits of present CAD technology. This method would be hard to extend to CIDER technology because of...D-Ri38 398 METHODOLOGY FOR BENEFIT ANALYSIS OF CAD/CAM / (COMPUTER-HIDED DESIGN/COMPUTER-AIDED MANUFACTURING) IN USN SHIPYARDS(U) NAVAL POSTGRADUATE

  5. Project-Based Teaching-Learning Computer-Aided Engineering Tools

    Science.gov (United States)

    Simoes, J. A.; Relvas, C.; Moreira, R.

    2004-01-01

    Computer-aided design, computer-aided manufacturing, computer-aided analysis, reverse engineering and rapid prototyping are tools that play an important key role within product design. These are areas of technical knowledge that must be part of engineering and industrial design courses' curricula. This paper describes our teaching experience of…

  6. Optimization of high-temperature superconductor current leads

    Science.gov (United States)

    Seol, S. Y.; Hull, J. R.; Chyu, M. C.

    Methods to improve the performance of high-temperature superconducting current leads are analyzed. Designs are considered that are inherently safe from burnup, even if the lead enters the normal state. The effect of a tapered lead that takes advantage of the increase in critical current density with decreasing temperature will decrease helium boiloff by about a factor of two for an area ratio of four. A new concept, in which Ag powder is distributed in increasing concentration from the cold end to the hot end of the lead in sintered YBCO, is shown to have comparable performance to that of leads made with Ag-alloy sheaths. Performance of the best inherently safe designs is about one order of magnitude better than that of optimized nonsuperconducting leads. BSCCO leads with Ag-alloy sheaths show improved performance for Au fractions up to about 3%, after which increases in Au fraction yield negligible performance improvement.

  7. Implantable defibrillator lead extraction with optimized standard extraction techniques

    Institute of Scientific and Technical Information of China (English)

    Xian-Ming Chu; Xue-Bin Li; Ping Zhang; Yi An; Jiang-Bo Duan; Long Wang; Ding Li; Bing Li; Ji-Hong Guo

    2013-01-01

    Background Implantable cardioverter-defibrillator (ICD) leads might not be extracted especially in developing countries because of the high cost and lack of specialized tools. We aimed to evaluate transvenous extraction of ICD leads using optimized standard techniques. Methods We prospectively analyzed clinical characteristics, optimized extraction techniques and the feasibility of extraction for 40 patients (33 males; mean age 47.9 ± 16.1 years) with 42 ICD leads. Results Complete procedural success rate was 95.2% (40/42), and the clinical success rate was 97.6% (41/42). One ICD lead required cardiothoracic surgery. Minor complications occurred in three cases (7.5%), and no major complications or death occurred. Locking stylets were used to extract most leads (34, 81.0%) and almost half of the leads (20, 47.6%) required mechanical dilatation to free fibrotic adhesions; these leads had been implanted for a longer period of time than the others (43.7 ± 18.2 vs. 18.4 ± 13.4 months, P < 0.05). Three-quarters of the leads (30, 71.4%) were extracted with locking stylets plus manual traction (12, 28.6%), or mechanical dilatation with counter-traction (18, 42.8%) by the superior vena cava approach and one-quarter of the leads (11, per lead. Linear regression analysis showed that the extraction time was significantly correlated with implant duration (r = 0.70, P < 0.001). optimized procedure for transvenous extraction of ICD leads provides a practical and low-cost method for standard procedures.

  8. Outsourcing lead optimization: the eye of the storm.

    Science.gov (United States)

    Clark, David E

    2011-02-01

    This article is the third in a series examining the evolution of the market for outsourced lead optimization services and covers developments from late 2006 to the present. Following an analysis of the significant events that have impacted the marketplace in recent years, a brief survey of the growing number of companies offering lead optimization services is presented. Subsequently, three notable trends that can be perceived in this highly dynamic field are discussed: the continuing rise of outsourcing companies in Asia and Eastern Europe, the increase in deals with not-for-profit organizations and, finally, the emergence of a variety of business models under which outsourced work is conducted.

  9. Imidazolopiperazines: hit to lead optimization of new antimalarial agents.

    Science.gov (United States)

    Wu, Tao; Nagle, Advait; Kuhen, Kelli; Gagaring, Kerstin; Borboa, Rachel; Francek, Caroline; Chen, Zhong; Plouffe, David; Goh, Anne; Lakshminarayana, Suresh B; Wu, Jeanette; Ang, Hui Qing; Zeng, Peiting; Kang, Min Low; Tan, William; Tan, Maria; Ye, Nicole; Lin, Xuena; Caldwell, Christopher; Ek, Jared; Skolnik, Suzanne; Liu, Fenghua; Wang, Jianling; Chang, Jonathan; Li, Chun; Hollenbeck, Thomas; Tuntland, Tove; Isbell, John; Fischli, Christoph; Brun, Reto; Rottmann, Matthias; Dartois, Veronique; Keller, Thomas; Diagana, Thierry; Winzeler, Elizabeth; Glynne, Richard; Tully, David C; Chatterjee, Arnab K

    2011-07-28

    Starting from a hit series from a GNF compound library collection and based on a cell-based proliferation assay of Plasmodium falciparum, a novel imidazolopiperazine scaffold was optimized. SAR for this series of compounds is discussed, focusing on optimization of cellular potency against wild-type and drug resistant parasites and improvement of physiochemical and pharmacokinetic properties. The lead compounds in this series showed good potencies in vitro and decent oral exposure levels in vivo. In a Plasmodium berghei mouse infection model, one lead compound lowered the parasitemia level by 99.4% after administration of 100 mg/kg single oral dose and prolonged mice survival by an average of 17.0 days. The lead compounds were also well-tolerated in the preliminary in vitro toxicity studies and represents an interesting lead for drug development.

  10. Computer-aided diagnosis of early knee osteoarthritis based on MRI T2 mapping.

    Science.gov (United States)

    Wu, Yixiao; Yang, Ran; Jia, Sen; Li, Zhanjun; Zhou, Zhiyang; Lou, Ting

    2014-01-01

    This work was aimed at studying the method of computer-aided diagnosis of early knee OA (OA: osteoarthritis). Based on the technique of MRI (MRI: Magnetic Resonance Imaging) T2 Mapping, through computer image processing, feature extraction, calculation and analysis via constructing a classifier, an effective computer-aided diagnosis method for knee OA was created to assist doctors in their accurate, timely and convenient detection of potential risk of OA. In order to evaluate this method, a total of 1380 data from the MRI images of 46 samples of knee joints were collected. These data were then modeled through linear regression on an offline general platform by the use of the ImageJ software, and a map of the physical parameter T2 was reconstructed. After the image processing, the T2 values of ten regions in the WORMS (WORMS: Whole-organ Magnetic Resonance Imaging Score) areas of the articular cartilage were extracted to be used as the eigenvalues in data mining. Then,a RBF (RBF: Radical Basis Function) network classifier was built to classify and identify the collected data. The classifier exhibited a final identification accuracy of 75%, indicating a good result of assisting diagnosis. Since the knee OA classifier constituted by a weights-directly-determined RBF neural network didn't require any iteration, our results demonstrated that the optimal weights, appropriate center and variance could be yielded through simple procedures. Furthermore, the accuracy for both the training samples and the testing samples from the normal group could reach 100%. Finally, the classifier was superior both in time efficiency and classification performance to the frequently used classifiers based on iterative learning. Thus it was suitable to be used as an aid to computer-aided diagnosis of early knee OA.

  11. Selection of Spatiotemporal Features in Breast MRI to Differentiate between Malignant and Benign Small Lesions Using Computer-Aided Diagnosis

    Directory of Open Access Journals (Sweden)

    F. Steinbruecker

    2012-01-01

    Full Text Available Automated detection and diagnosis of small lesions in breast MRI represents a challenge for the traditional computer-aided diagnosis (CAD systems. The goal of the present research was to compare and determine the optimal feature sets describing the morphology and the enhancement kinetic features for a set of small lesions and to determine their diagnostic performance. For each of the small lesions, we extracted morphological and dynamical features describing both global and local shape, and kinetics behavior. In this paper, we compare the performance of each extracted feature set for the differential diagnosis of enhancing lesions in breast MRI. Based on several simulation results, we determined the optimal feature number and tested different classification techniques. The results suggest that the computerized analysis system based on spatiotemporal features has the potential to increase the diagnostic accuracy of MRI mammography for small lesions and can be used as a basis for computer-aided diagnosis of breast cancer with MR mammography.

  12. Exploring Natural Products as a Source for Antidiabetic Lead Compounds and Possible Lead Optimization.

    Science.gov (United States)

    Khalaf, Reema Abu

    2016-01-01

    Natural products are characterized by their chemical diversity and being a good source of a range of bioactive structures including antidiabetic compounds. Diabetes mellitus (DM) is considered a major worldwide health concern. Rational drug design has been widely accomplished, to discover and optimize innovative leads for different molecular targets of type 2 DM including α-glucosidase, PPARγ, DPP-IV, PTP1B, AR, GSK-3β, 11β-HSD1, GK, etc. This review illustrates the potential of natural products as a rich source of lead compounds for antidiabetic drug discovery with some examples of computational studies carried out to determine the possible molecular target, structure activity relationship, and further optimization chances. Natural products will remain an attractive source for researchers to explore their therapeutic potential against DM. Guided by the computational studies; systematic lead optimization via structural modifications will speed up the generation of potential new clinical candidates for the treatment of type 2 DM.

  13. [Computer-aided prescribing: from utopia to reality].

    Science.gov (United States)

    Suárez-Varela Ubeda, J; Beltrán Calvo, C; Molina López, T; Navarro Marín, P

    2005-05-31

    To determine whether the introduction of computer-aided prescribing helped reduce the administrative burden at primary care centers. Descriptive, cross-sectional design. Torreblanca Health Center in the province of Seville, southern Spain. From 29 October 2003 to the present a pilot project involving nine pharmacies in the basic health zone served by this health center has been running to evaluate computer-aided prescribing (the Receta XXI project) with real patients. All patients on the center's list of patients who came to the center for an administrative consultation to renew prescriptions for medications or supplies for long-term treatment. Total number of administrative visits per patient for patients who came to the center to renew prescriptions for long-term treatment, as recorded by the Diraya system (Historia Clinica Digital del Ciudadano, or Citizen's Digital Medical Record) during the period from February to July 2004. Total number of the same type of administrative visits recorded by the previous system (TASS) during the period from February to July 2003. The mean number of administrative visits per month during the period from February to July 2003 was 160, compared to a mean number of 64 visits during the period from February to July 2004. The reduction in the number of visits for prescription renewal was 60%. Introducing a system for computer-aided prescribing significantly reduced the number of administrative visits for prescription renewal for long-term treatment. This could help reduce the administrative burden considerably in primary care if the system were used in all centers.

  14. CATIA Core Tools Computer Aided Three-Dimensional Interactive Application

    CERN Document Server

    Michaud, Michel

    2012-01-01

    CATIA Core Tools: Computer-Aided Three-Dimensional Interactive Application explains how to use the essential features of this cutting-edge solution for product design and innovation. The book begins with the basics, such as launching the software, configuring the settings, and managing files. Next, you'll learn about sketching, modeling, drafting, and visualization tools and techniques. Easy-to-follow instructions along with detailed illustrations and screenshots help you get started using several CATIA workbenches right away. Reverse engineering--a valuable product development skill--is also covered in this practical resource.

  15. Efficient Use of Preisach Hysteresis Model in Computer Aided Design

    Directory of Open Access Journals (Sweden)

    IONITA, V.

    2013-05-01

    Full Text Available The paper presents a practical detailed analysis regarding the use of the classical Preisach hysteresis model, covering all the steps, from measuring the necessary data for the model identification to the implementation in a software code for Computer Aided Design (CAD in Electrical Engineering. An efficient numerical method is proposed and the hysteresis modeling accuracy is tested on magnetic recording materials. The procedure includes the correction of the experimental data, which are used for the hysteresis model identification, taking into account the demagnetizing effect for the sample that is measured in an open-circuit device (a vibrating sample magnetometer.

  16. A Computer Aided Consultant System for Mammogram Diagnosis

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    A computer-aided consultant system for mammogram diagnosis is proposed in this paper based on mam-mogram segmentation as an image mining technique, to aid radiologistis in X-ray film interpretation. The generalarchitecture of the system is introduced first, followed by a discussion of mammogram segmentation using logic fil-ter, an analysis of the statistical data to the diagnostics with respect to different clinical information, and a brief in-troduction to a fuzzy decision making subsystem. Finally some experimental results are given.

  17. Computer-Aided Design Of Sheet-Material Parts

    Science.gov (United States)

    Gilbert, Jeffrey L.; Paternoster, Vincent Y.; Levitt, Maureen L.; Osterloh, Mark R.

    1991-01-01

    Computer-aided-design system partly automates tedious process of designing and guiding assembly of small pieces of flat sheet material into large surfaces that approximate smoothly curved surfaces having complicated three-dimensional shapes. Capability provides for flexibility enabling designer to assess quickly and easily effects of changes in design in making engineering compromises among various sizes and shapes. Saves time and money in both design and fabrication. Used in rocket-engine application and other applications requiring design of sheet-material parts.

  18. Technology computer aided design simulation for VLSI MOSFET

    CERN Document Server

    Sarkar, Chandan Kumar

    2013-01-01

    Responding to recent developments and a growing VLSI circuit manufacturing market, Technology Computer Aided Design: Simulation for VLSI MOSFET examines advanced MOSFET processes and devices through TCAD numerical simulations. The book provides a balanced summary of TCAD and MOSFET basic concepts, equations, physics, and new technologies related to TCAD and MOSFET. A firm grasp of these concepts allows for the design of better models, thus streamlining the design process, saving time and money. This book places emphasis on the importance of modeling and simulations of VLSI MOS transistors and

  19. CADEE: Computer-Aided Directed Evolution of Enzymes

    Directory of Open Access Journals (Sweden)

    Beat Anton Amrein

    2017-01-01

    Full Text Available The tremendous interest in enzymes as biocatalysts has led to extensive work in enzyme engineering, as well as associated methodology development. Here, a new framework for computer-aided directed evolution of enzymes (CADEE is presented which allows a drastic reduction in the time necessary to prepare and analyze in silico semi-automated directed evolution of enzymes. A pedagogical example of the application of CADEE to a real biological system is also presented in order to illustrate the CADEE workflow.

  20. SNL Mechanical Computer Aided Design (MCAD) guide 2007.

    Energy Technology Data Exchange (ETDEWEB)

    Moore, Brandon; Pollice, Stephanie L.; Martinez, Jack R.

    2007-12-01

    This document is considered a mechanical design best-practice guide to new and experienced designers alike. The contents consist of topics related to using Computer Aided Design (CAD) software, performing basic analyses, and using configuration management. The details specific to a particular topic have been leveraged against existing Product Realization Standard (PRS) and Technical Business Practice (TBP) requirements while maintaining alignment with sound engineering and design practices. This document is to be considered dynamic in that subsequent updates will be reflected in the main title, and each update will be published on an annual basis.

  1. 9th Asian Conference on Computer-Aided Surgery

    CERN Document Server

    2016-01-01

    This book presents the latest research advances in the theory, design, control, and application of robot systems intended for a variety of purposes such as manipulation, manufacturing, automation, surgery, locomotion, and biomechanics. Several chapters deal with fundamental kinematics in nature, including synthesis, calibration, redundancy, force control, dexterity, inverse and forward kinematics, kinematic singularities, and over-constrained systems. This book is a compilation of the extended versions of the very best papers selected from the many that were presented at the Asian Conference on Computer-Aided Surgery held September 16–18, 2013, in Tokyo, Japan (ACCAS 2013).

  2. Retrospective indexing (RI) - A computer-aided indexing technique

    Science.gov (United States)

    Buchan, Ronald L.

    1990-01-01

    An account is given of a method for data base-updating designated 'computer-aided indexing' (CAI) which has been very efficiently implemented at NASA's Scientific and Technical Information Facility by means of retrospective indexing. Novel terms added to the NASA Thesaurus will therefore proceed directly into both the NASA-RECON aerospace information system and its portion of the ESA-Information Retrieval Service, giving users full access to material thus indexed. If a given term appears in the title of a record, it is given special weight. An illustrative graphic representation of the CAI search strategy is presented.

  3. Selecting and effectively using a computer aided software engineering tool

    Energy Technology Data Exchange (ETDEWEB)

    Kuhn, D.L.

    1989-01-01

    Software engineering is a science by which user requirements are translated into a quality software product. Computer Aided Software Engineering (CASE) is the scientific application of a set of tools and methods to a software which results in high-quality, defect-free, and maintainable software products. The Computer Systems Engineering (CSE) group of Separations Technology at the Savannah River Site has successfully used CASE tools to produce high-quality, reliable, and maintainable software products. This paper details the selection process CSE used to acquire a commonly available CASE product and how the CSE group effectively used this CASE tool to consistently produce quality software. 9 refs.

  4. A comparative study of two computer-aided measurement methods

    OpenAIRE

    Gronau, Franziska

    2010-01-01

    Growth and developmental disorders of the elbow joint are frequent causes of lameness of the thoracic limb of the dog. Golden Retriever is one of the mainly affected breeds. Two different computer-aided methods of measurement will be compared in this study. The aim is to find out whether one of these measurement methods is more suitable to distinguish affected from unaffected joints and to recognize a possible predisposition for elbow dysplasia (ED). X-Rays of the elbow joints in the medio-la...

  5. Simultaneous Computer-Aided Design/Computer-Aided Manufacture Bimaxillary Orthognathic Surgery and Mandibular Reconstruction Using Selective-Laser Sintered Titanium Implant.

    Science.gov (United States)

    Hatamleh, Muhanad M; Bhamrah, Gurprit; Ryba, Francine; Mack, Gavin; Huppa, Chrisopher

    2016-10-01

    This patient report describes simultaneous bimaxillary orthognathic surgery and mandibular reconstruction by means of three-dimensional (3D) planning, 3D printed biocompatible surgical wafers, and 3D selective-laser sintered titanium implant. A 26-year-old male patient presented with a left mandibular defect secondary to trauma. The whole body of the mandible on the left hand side was deficient with a narrow connection with the remaining left condyle. He had undergone orthodontic treatment for 18 months and was ready to undergo bimaxillary orthognathic surgery. Advanced cranio-maxillofacial software was used in processing his cone beam computer tomography scan data, and e-casts of his upper and lower dental arches. Bimaxillary surgery was planned with Le Fort 1 maxillary impaction and mandibular advancement to achieve a class 1 incisor relationship. Intermediate and final surgical wafers were designed following the planned movements and printed using biocompatible resin. The deficient left side of the mandible was reconstructed by means of mirror imaging the contra-lateral right side into the deficient left side with the aim of restoring normal facial symmetry. Biomedical software was then used in designing a reconstruction plate that connected the condylar head and the mandible following the planned bimaxillary surgery and mandibular continuity symmetry reconstruction. The plate was printed in titanium following state-of the-art selective laser sintering technology. The bimaxillary surgery and mandibular reconstruction were done simultaneously as planned along with an iliac-crest bone graft. This patient confirms the advantages of 3D computer-aided design/computer-aided manufacture technologies in optimizing clinical outcomes for cranio-maxillofacial reconstruction, especially when conducting two simultaneous clinical procedures.

  6. Computer-Aided System of Virtual Testing of Gas Turbine Engines

    Directory of Open Access Journals (Sweden)

    Rybakov Viktor N.

    2016-01-01

    Full Text Available The article describes the concept of a virtual lab that includes subsystem of gas turbine engine simulation, subsystem of experiment planning, subsystem of measurement errors simulation, subsystem of simulator identification and others. The basis for virtual lab development is the computer-aided system of thermogasdynamic research and analysis “ASTRA”. The features of gas turbine engine transient modes simulator are described. The principal difference between the simulators of transient and stationary modes of gas turbine engines is that the energy balance of the compressor and turbine becomes not applicable. The computer-aided system of virtual gas turbine engine testing was created using the developed transient modes simulator. This system solves the tasks of operational (throttling, speed, climatic, altitude characteristics calculation, analysis of transient dynamics and selection of optimal control laws. Besides, the system of virtual gas turbine engine testing is a clear demonstration of gas turbine engine working process and the regularities of engine elements collaboration. The interface of the system of virtual gas turbine engine testing is described in the article and some screenshots of the interface elements are provided. The developed system of virtual gas turbine engine testing provides means for reducing the laboriousness of gas turbine engines testing. Besides, the implementation of this system in the learning process allows the diversification of lab works and therefore improve the quality of training.

  7. Computer Aided Design and Analysis of a 2-4 GHz Broadband Balanced Microstrip Amplifier

    Directory of Open Access Journals (Sweden)

    S. H. Ibrahim

    2012-07-01

    Full Text Available In this paper, a computer-aided design and analysis of a 2-4 GHz broadband balanced microstrip amplifier using a full computer simulation program developed by the author and others is presented. A short and efficient CAD procedure for broadband amplifier design is introduced. The first step is to design an initial narrow-band high gain microstrip amplifier at 3-GHz central frequency. The second step is to optimize the initial lengths and widths of the input and output microstrip-matching circuits to get the broadband amplifier over the range 2-4 GHz. The analysis of both narrow and broadband amplifiers is investigated. In addition, with the design and analysis of a low-pass microstrip filter, the paper introduces the design and analysis of a Lange coupler. The final AC schematic diagram of the designed amplifier with the lengths and widths of microstrip lines is presented.Key Words: Computer-Aided Design and Analysis, Microstrip Amplifier, Microwave Amplifier.

  8. Computer Aided Engineering of Cyber-Physical Information Gathering and Utilizing Systems

    Directory of Open Access Journals (Sweden)

    Alfred P. Defonzo

    2012-08-01

    Full Text Available Engineering Cyber-physical information gathering and utilizing systems(CIGUS presents the systems engineer with a difficult, multi-criterion, multi-objective decision problem. Research, development and design is done over many disciplines, across many domains, each with their specific models. Systems engineers are expected to provide a common level of communication amongst the domains to promote convergence to a design. We present novel information measures that enable combination of the underlying domain specific subsystems parameters in a way that makes the information yield of the system intelligible to decision makers and domain experts. These measures enable, for the first time, the application of multi-objective evolutionary algorithms and end-to-end computer aided engineering of CIGUS. Our novel approach is validated and verified through the application and direct comparison of simulated and experimental results of state-ofthe- art weather radar network test bed designs. The approach resulted in Pareto optimal point within an average of 10% of the actual case study design parameters and within 25% of the Pareto ideal point. No additional parameters beyond the underlying domain parameters were introduced. This demonstrates that the computationally aided engineering approach presented in this work facilitates engineering feasibility decisions and the subsequent evolution of the engineered systems in way that reduces cost and effort.

  9. Computer-aided ultrasonic inspection of steam turbine rotors

    Energy Technology Data Exchange (ETDEWEB)

    Mayer, K.H.; Weber, M.; Weiss, M. [GEC ALSTHOM Energie GmbH, Nuremberg (Germany)

    1998-12-31

    As the output and economic value of power plants increase, the detection and sizing of the type of flaws liable to occur in the rotors of turbines using ultrasonic methods assumes increasing importance. An ultrasonic inspection carried out at considerable expense is expected to bring to light all safety-relevant flaws and to enable their size to be determined so as to permit a fracture-mechanics analysis to assess the reliability of the rotor under all possible stresses arising in operation with a high degree of accuracy. The advanced computer-aided ultrasonic inspection of steam turbine rotors have improved reliability, accuracy and reproducibility of ultrasonic inspection. Further, there has been an improvement in the resolution of resolvable group indications by applying reconstruction and imagine methods. In general, it is also true for the advanced computer-aided ultrasonic inspection methods that, in the case of flaw-affected forgings, automated data acquisition provides a substantial rationalization and a significant documentation of the results for the fracture mechanics assessment compared to manual inspection. (orig.) 8 refs.

  10. NALDA (Naval Aviation Logistics Data Analysis) CAI (computer aided instruction)

    Energy Technology Data Exchange (ETDEWEB)

    Handler, B.H. (Oak Ridge K-25 Site, TN (USA)); France, P.A.; Frey, S.C.; Gaubas, N.F.; Hyland, K.J.; Lindsey, A.M.; Manley, D.O. (Oak Ridge Associated Universities, Inc., TN (USA)); Hunnum, W.H. (North Carolina Univ., Chapel Hill, NC (USA)); Smith, D.L. (Memphis State Univ., TN (USA))

    1990-07-01

    Data Systems Engineering Organization (DSEO) personnel developed a prototype computer aided instruction CAI system for the Naval Aviation Logistics Data Analysis (NALDA) system. The objective of this project was to provide a CAI prototype that could be used as an enhancement to existing NALDA training. The CAI prototype project was performed in phases. The task undertaken in Phase I was to analyze the problem and the alternative solutions and to develop a set of recommendations on how best to proceed. The findings from Phase I are documented in Recommended CAI Approach for the NALDA System (Duncan et al., 1987). In Phase II, a structured design and specifications were developed, and a prototype CAI system was created. A report, NALDA CAI Prototype: Phase II Final Report, was written to record the findings and results of Phase II. NALDA CAI: Recommendations for an Advanced Instructional Model, is comprised of related papers encompassing research on computer aided instruction CAI, newly developing training technologies, instructional systems development, and an Advanced Instructional Model. These topics were selected because of their relevancy to the CAI needs of NALDA. These papers provide general background information on various aspects of CAI and give a broad overview of new technologies and their impact on the future design and development of training programs. The paper within have been index separately elsewhere.

  11. Assessment technique for computer-aided manufactured sockets

    Directory of Open Access Journals (Sweden)

    Joan E. Sanders, PhD

    2011-08-01

    Full Text Available This article presents an assessment technique for testing the quality of prosthetic socket fabrication processes at computer-aided manufacturing facilities. The assessment technique is potentially useful to both facilities making sockets and companies marketing manufacturing equipment seeking to assess and improve product quality. To execute the assessment technique, an evaluator fabricates a collection of test models and sockets using the manufacturing suite under evaluation, then measures their shapes using scanning equipment. Overall socket quality is assessed by comparing socket shapes with electronic file (e-file shapes. To characterize carving performance, model shapes are compared with e-file shapes. To characterize forming performance, socket shapes are compared with model shapes. The mean radial error (MRE, which is the average difference in radii between the two compared shapes, provides insight into sizing quality. Interquartile range (IQR, the range of radial error for the best-matched half of the points on the compared socket surfaces, provides insight into regional shape quality. The source(s of socket shape error may be pinpointed by separately determining MRE and IQR for carving and forming. The developed assessment technique may provide a useful tool to the prosthetics community and industry to help identify problems and limitations in computer-aided manufacturing and give insight into appropriate modifications to overcome them.

  12. Computer-aided light sheet flow visualization using photogrammetry

    Science.gov (United States)

    Stacy, Kathryn; Severance, Kurt; Childers, Brooks A.

    1994-01-01

    A computer-aided flow visualization process has been developed to analyze video images acquired from rotating and translating light sheet visualization systems. The computer process integrates a mathematical model for image reconstruction, advanced computer graphics concepts, and digital image processing to provide a quantitative and a visual analysis capability. The image reconstruction model, based on photogrammetry, uses knowledge of the camera and light sheet locations and orientations to project two-dimensional light sheet video images into three-dimensional space. A sophisticated computer visualization package, commonly used to analyze computational fluid dynamics (CFD) results, was chosen to interactively display the reconstructed light sheet images with the numerical surface geometry for the model or aircraft under study. The photogrammetric reconstruction technique and the image processing and computer graphics techniques and equipment are described. Results of the computer-aided process applied to both a wind tunnel translating light sheet experiment and an in-flight rotating light sheet experiment are presented. The capability to compare reconstructed experimental light sheet images with CFD solutions in the same graphics environment is also demonstrated.

  13. Computer-aided morphometry of liver inflammation in needle biopsies

    Institute of Scientific and Technical Information of China (English)

    N Dioguardi; B Franceschini; C Russo; F Grizzi

    2005-01-01

    AIM: To introduce a computer-aided morphometric method for quantifying the necro-inflammatory phase in liver biopsy specimens using fractal geometry and Delaunay's triangulation.METHODS: Two-micrometer thick biopsy sections taken from 78 chronic hepatitis C virus-infected patients were immunohistochemically treated to identify the inflammatory cells. An automatic computer-aided image analysis system was used to define the inflammatory cell network defined on the basis of Delaunay's triangulation,and the inflammatory cells were geometrically classified as forming a cluster (an aggregation of a minimum of three cells) or as being irregularly distributed within the tissue. The phase of inflammatory activity was estimated using Hurst's exponent.RESULTS: The proposed automatic method was rapid and objective. It could not only provide rigorous results expressed by scalar numbers, but also allow the state of the whole organ to be represented by Hurst's exponent with an error of no more than 12%.CONCLUSION: The availability of rigorous metrical measures and the reasonable representativeness of the status of the organ as a whole raise the question as to whether the indication for hepatic biopsy should be revised by establishing clear rules concerning the contraindications suggested by its invasiveness and subjective interpretation.

  14. Computer-aided dermoscopy for diagnosis of melanoma

    Directory of Open Access Journals (Sweden)

    Naraghi Zahra S

    2005-07-01

    Full Text Available Abstract Background Computer-aided dermoscopy using artificial neural networks has been reported to be an accurate tool for the evaluation of pigmented skin lesions. We set out to determine the sensitivity and specificity of a computer-aided dermoscopy system for diagnosis of melanoma in Iranian patients. Methods We studied 122 pigmented skin lesions which were referred for diagnostic evaluation or cosmetic reasons. Each lesion was examined by two clinicians with naked eyes and all of their clinical diagnostic considerations were recorded. The lesions were analyzed using a microDERM® dermoscopy unit. The output value of the software for each lesion was a score between 0 and 10. All of the lesions were excised and examined histologically. Results Histopathological examination revealed melanoma in six lesions. Considering only the most likely clinical diagnosis, sensitivity and specificity of clinical examination for diagnosis of melanoma were 83% and 96%, respectively. Considering all clinical diagnostic considerations, the sensitivity and specificity were 100% and 89%. Choosing a cut-off point of 7.88 for dermoscopy score, the sensitivity and specificity of the score for diagnosis of melanoma were 83% and 96%, respectively. Setting the cut-off point at 7.34, the sensitivity and specificity were 100% and 90%. Conclusion The diagnostic accuracy of the dermoscopy system was at the level of clinical examination by dermatologists with naked eyes. This system may represent a useful tool for screening of melanoma, particularly at centers not experienced in the field of pigmented skin lesions.

  15. A Robust and Fast System for CTC Computer-Aided Detection of Colorectal Lesions

    Directory of Open Access Journals (Sweden)

    Gareth Beddoe

    2010-01-01

    Full Text Available We present a complete, end-to-end computer-aided detection (CAD system for identifying lesions in the colon, imaged with computed tomography (CT. This system includes facilities for colon segmentation, candidate generation, feature analysis, and classification. The algorithms have been designed to offer robust performance to variation in image data and patient preparation. By utilizing efficient 2D and 3D processing, software optimizations, multi-threading, feature selection, and an optimized cascade classifier, the CAD system quickly determines a set of detection marks. The colon CAD system has been validated on the largest set of data to date, and demonstrates excellent performance, in terms of its high sensitivity, low false positive rate, and computational efficiency.

  16. [Computer-aided method and rapid prototyping for the personalized fabrication of a silicone bandage digital prosthesis].

    Science.gov (United States)

    Ventura Ferreira, Nuno; Leal, Nuno; Correia Sá, Inês; Reis, Ana; Marques, Marisa

    2014-01-01

    The fabrication of digital prostheses has acquired growing importance not only for the possibility for the patient to overcome psychosocial trauma but also to promote grip functionality. An application method of three dimensional-computer-aided design technologies for the production of passive prostheses is presented by means of a fifth finger amputee clinical case following bilateral hand replantation.Three-dimensional-computerized tomography was used for the collection of anthropometric images of the hands. Computer-aided design techniques were used to develop the digital file-based prosthesis from the reconstruction images by inversion and superimposing the contra-lateral finger images. The rapid prototyping manufacturing method was used for the production of a silicone bandage prosthesis prototype. This approach replaces the traditional manual method by a virtual method that is basis for the optimization of a high speed, accurate and innovative process.

  17. Computer-aided design of bromelain and papain covalent immobilization

    Directory of Open Access Journals (Sweden)

    Bessy Cutiño-Avila

    2014-06-01

    Full Text Available Título en español: Diseño asistido por computadora de la inmovilización covalente de bromelina y papaína.Título corto: Computer-aided design of bromelain and papain. Abstract: Enzymes as immobilized derivatives have been widely used in Food, Agrochemical, Pharmaceutical and Biotechnological industries. Protein immobilization is probably the most used technology to improve the operational stability of these molecules. Bromelain (Ananas comosus and papain (Carica papaya are cystein proteases extensively used as immobilized biocatalyst with several applications in therapeutics, racemic mixtures resolution, affinity chromatography and others industrial scenarios. The aim of this work was to optimize the covalent immobilization of bromelain and papain via rational design of immobilized derivatives strategy (RDID and RDID1.0 program. It was determined the maximum protein quantity to immobilize, the optimum immobilization pH (in terms of functional activity retention, and the most probable configuration of the immobilized derivative and the probabilities of multipoint covalent attachment was also predicted. As support material Glyoxyl-Sepharose CL 4B was used.  The accuracy of RDID1.0 program´s prediction was demonstrated comparing with experimental results. Bromelain and papain immobilized derivatives showed desired characteristics for industrial biocatalysis, such as: elevate pH stability retaining 95% and 100% residual activity at pH 7.0 and 8.0, for bromelain and papain, respectively; high thermal stability at 30 °C retaining 90% residual activity for both immobilized enzymes; a catalytic configuration bonded by immobilization at optimal pH; and the ligand load achieved, ensures the minimization of diffusional restrictions.Key words: bromelain, covalent immobilization, immobilized derivatives, papain, rational design.Resumen: Las enzimas inmovilizadas han sido ampliamente utilizadas en las industrias Alimentaria, Agroquímica, Farmac

  18. [Lead compound optimization strategy (1)--changing metabolic pathways and optimizing metabolism stability].

    Science.gov (United States)

    Wang, Jiang; Liu, Hong

    2013-10-01

    Lead compound optimization plays an important role in new drug discovery and development. The strategies for changing metabolic pathways can modulate pharmacokinetic properties, prolong the half life, improve metabolism stability and bioavailability of lead compounds. The strategies for changing metabolic pathways and improving metabolism stability are reviewed. These methods include blocking metabolic site, reduing lipophilicity, changing ring size, bioisosterism, and prodrug.

  19. Computer-aided diagnosis in chest radiography: Beyond nodules

    Energy Technology Data Exchange (ETDEWEB)

    Ginneken, Bram van [University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht (Netherlands)], E-mail: bram@isi.uu.nl; Hogeweg, Laurens; Prokop, Mathias [University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht (Netherlands)

    2009-11-15

    Chest radiographs are the most common exam in radiology. They are essential for the management of various diseases associated with high mortality and morbidity and display a wide range of findings, many of them subtle. In this survey we identify a number of areas beyond pulmonary nodules that could benefit from computer-aided detection and diagnosis (CAD) in chest radiography. These include interstitial infiltrates, catheter tip detection, size measurements, detection of pneumothorax and detection and quantification of emphysema. Recent work in these areas is surveyed, but we conclude that the amount of research devoted to these topics is modest. Reasons for the slow pace of CAD development in chest radiography beyond nodules are discussed.

  20. Computer-Aided Numerical Inversion of Laplace Transform

    Directory of Open Access Journals (Sweden)

    Umesh Kumar

    2000-01-01

    Full Text Available This paper explores the technique for the computer aided numerical inversion of Laplace transform. The inversion technique is based on the properties of a family of three parameter exponential probability density functions. The only limitation in the technique is the word length of the computer being used. The Laplace transform has been used extensively in the frequency domain solution of linear, lumped time invariant networks but its application to the time domain has been limited, mainly because of the difficulty in finding the necessary poles and residues. The numerical inversion technique mentioned above does away with the poles and residues but uses precomputed numbers to find the time response. This technique is applicable to the solution of partially differentiable equations and certain classes of linear systems with time varying components.

  1. Computer-aided conceptual design of Air Cushion Vehicles

    Science.gov (United States)

    Band, E. G. U.; Lavis, D. R.

    This paper describes the development and use of a computer-aided design tool which has been used to explore preferred options for amphibious Air-Cushion Vehicle (ACV) and Surface-Effect Ship (SES) designs in support of U.S. Navy and U.S. Army programs. The tool, referred to as the ACV Design Synthesis Model (ADSM), is an interactive computer program which provides a description of feasible ACV or SES concepts that could be developed, by a competent design team, to perform the mission described by the input parameters. The paper discusses how the program was used to explore parametrically the design of a range of self-propelled hoverbarges to meet requirements of the U.S. Army Logistics Over the Shore (LOTS) phases of an amphibious landing. Examples of results are presented to illustrate the method used in determining design and performance trade-offs.

  2. 13th International Conference on Computer Aided Engineering

    CERN Document Server

    Pietrusiak, Damian

    2017-01-01

    These proceedings of the 13th International Conference on Computer Aided Engineering present selected papers from the event, which was held in Polanica Zdrój, Poland, from June 22 to 25, 2016. The contributions are organized according to thematic sections on the design and manufacture of machines and technical systems; durability prediction; repairs and retrofitting of power equipment; strength and thermodynamic analyses for power equipment; design and calculation of various types of load-carrying structures; numerical methods for dimensioning materials handling; and long-distance transport equipment. The conference and its proceedings offer a major interdisciplinary forum for researchers and engineers to present the most innovative studies and advances in this dynamic field.

  3. Computer aided microbial safety design of food processes.

    Science.gov (United States)

    Schellekens, M; Martens, T; Roberts, T A; Mackey, B M; Nicolaï, B M; Van Impe, J F; De Baerdemaeker, J

    1994-12-01

    To reduce the time required for product development, to avoid expensive experimental tests, and to quantify safety risks for fresh products and the consequence of processing there is a growing interest in computer aided food process design. This paper discusses the application of hybrid object-oriented and rule-based expert system technology to represent the data and knowledge of microbial experts and food engineers. Finite element models for heat transfer calculation routines, microbial growth and inactivation models and texture kinetics are combined with food composition data, thermophysical properties, process steps and expert knowledge on type and quantity of microbial contamination. A prototype system has been developed to evaluate changes in food composition, process steps and process parameters on microbiological safety and textual quality of foods.

  4. Computer-Aided Multiscale Modelling for Chemical Process Engineering

    DEFF Research Database (Denmark)

    Morales Rodriguez, Ricardo; Gani, Rafiqul

    2007-01-01

    T) for model translation, analysis and solution. The integration of ModDev, MoT and ICAS or any other external software or process simulator (using COM-Objects) permits the generation of different models and/or process configurations for purposes of simulation, design and analysis. Consequently, it is possible......Chemical processes are generally modeled through monoscale approaches, which, while not adequate, satisfy a useful role in product-process design. In this case, use of a multi-dimensional and multi-scale model-based approach has importance in product-process development. A computer-aided framework...... for model generation, analysis, solution and implementation is necessary for the development and application of the desired model-based approach for product-centric process design/analysis. This goal is achieved through the combination of a system for model development (ModDev), and a modelling tool (Mo...

  5. Systematic Computer-Aided Framework for Sustainable Chemical Product Design

    DEFF Research Database (Denmark)

    Cignitti, Stefano; Zhang, Lei; Kalakul, Sawitree

    Computer-aided product design (CAPD) is a method for the generation and selection of novel pure, mixed and blended chemical products [1]. In CAPD, the chemical product is generated and selected based on defined structure, property and process/application constraints. Several challenges exist...... for CAPD, including the accuracy of the property estimation, molecular structure generation, inclusion of sustainability, process and application targets and needs in the problem formulation. CAPD has been widely utilized for the synthesis of several types of products, such as solvents, polymers, fuels...... and formulated products [2]. However, for product design problems where the process needs and sustainability possess demanding constraints, the complexity of the problem is increased as the relation between product property, sustainability and process criteria is difficult to mathematically define. In this work...

  6. Computer aided planning and navigation for orbito-zygomatic reconstruction

    CERN Document Server

    Marecaux, Christophe; Payan, Yohan; Boutault, Franck

    2007-01-01

    This paper suggests a full protocol of Computer Aided Surgery as previously recommended in literature addressing the challenging task of primary or secondary reconstruction of orbito-zygomatic dislocation. First, on a specifically developed planning software, the best zygoma reduction and orbital boundaries reconstruction to achieve skeletal symmetry are determined. This treatment plan is then transferred to the 3D Navigation Systems within the operating room. After patient's anatomy registration to his preoperative CT scan data, the navigation system allows zygomatic guiding to its planned reduced location and bone orbital volume restoration control. The feasibility of this technique was checked in 3 patients with major orbito-zygomatic deformities. Preliminary clinical results are presented.

  7. Computer aided systems human engineering: A hypermedia tool

    Science.gov (United States)

    Boff, Kenneth R.; Monk, Donald L.; Cody, William J.

    1992-01-01

    The Computer Aided Systems Human Engineering (CASHE) system, Version 1.0, is a multimedia ergonomics database on CD-ROM for the Apple Macintosh II computer, being developed for use by human system designers, educators, and researchers. It will initially be available on CD-ROM and will allow users to access ergonomics data and models stored electronically as text, graphics, and audio. The CASHE CD-ROM, Version 1.0 will contain the Boff and Lincoln (1988) Engineering Data Compendium, MIL-STD-1472D and a unique, interactive simulation capability, the Perception and Performance Prototyper. Its features also include a specialized data retrieval, scaling, and analysis capability and the state of the art in information retrieval, browsing, and navigation.

  8. Computer-aided modeling framework – a generic modeling template

    DEFF Research Database (Denmark)

    Fedorova, Marina; Sin, Gürkan; Gani, Rafiqul

    This work focuses on the development of a computer-aided modeling framework. The framework is a knowledge-based system that is built on a generic modeling language and structured on workflows for different modeling tasks. The overall objective is to support model developers and users to generate...... and test models systematically, efficiently and reliably. In this way, development of products and processes can be made faster, cheaper and more efficient. In this contribution, as part of the framework, a generic modeling template for the systematic derivation of problem specific models is presented....... The application of the modeling template is highlighted with a case study related to the modeling of a catalytic membrane reactor coupling dehydrogenation of ethylbenzene with hydrogenation of nitrobenzene...

  9. Computer-aided assessment in statistics: the CAMPUS project

    Directory of Open Access Journals (Sweden)

    Neville Hunt

    1998-12-01

    Full Text Available The relentless drive for 'efficiency' in higher education, and the consequent increase in workloads, has given university teachers a compelling incentive to investigate alternative forms of assessment. Some forms of assessment with a clear educational value can no longer be entertained because of the burden placed on the teacher. An added concern is plagiarism, which anecdotal evidence would suggest is on the increase yet which is difficult to detect in large modules with more than one assessor. While computer-aided assessment (CAA has an enthusiastic following, it is not clear to many teachers that it either reduces workloads or reduces the risk of cheating. In an ideal world, most teachers would prefer to give individual attention and personal feedback to each student when marking their work. In this sense CAA must be seen as second best and will therefore be used only if it is seen to offer significant benefits in terms of reduced workloads or increased validity.

  10. Computer Aided Safety Assessment(CASA) Tool for ISS Payloads

    Science.gov (United States)

    Hochstein, Jason; Festa, Fabrizio

    2010-09-01

    In an effort to streamline the processes established by the partners of the International Space Station(ISS) to certify the safety of hardware and experiments destined for the Station, the European Space Agency’s(ESA) ISS System Safety Team is developing the Computer Aided Safety Assessment(CASA) tool suite. These software tools guide payload developers through the creation process of two types of standard payload hazard reports via a series of questions following a predetermined logic. The responses provided by the user are used by the CASA system to complete the majority of each hazard report requisite for payload flight safety reviews, employing consistent, approved descriptions of most hazards, hazard causes, controls and verification methods. Though some manual inputs will still be required to complete these reports, working with CASA will considerably reduce the amount of time necessary to review the documentation by agency safety authorities.

  11. Systematic Methods and Tools for Computer Aided Modelling

    DEFF Research Database (Denmark)

    Fedorova, Marina

    -friendly system, which will make the model development process easier and faster and provide the way for unified and consistent model documentation. The modeller can use the template for their specific problem or to extend and/or adopt a model. This is based on the idea of model reuse, which emphasizes the use...... and processes can be faster, cheaper and very efficient. The developed modelling framework involves five main elements: 1) a modelling tool, that includes algorithms for model generation; 2) a template library, which provides building blocks for the templates (generic models previously developed); 3) computer...... aided methods and tools, that include procedures to perform model translation, model analysis, model verification/validation, model solution and model documentation; 4) model transfer – export/import to/from other application for further extension and application – several types of formats, such as XML...

  12. PACS-Based Computer-Aided Detection and Diagnosis

    Science.gov (United States)

    Huang, H. K. (Bernie); Liu, Brent J.; Le, Anh HongTu; Documet, Jorge

    The ultimate goal of Picture Archiving and Communication System (PACS)-based Computer-Aided Detection and Diagnosis (CAD) is to integrate CAD results into daily clinical practice so that it becomes a second reader to aid the radiologist's diagnosis. Integration of CAD and Hospital Information System (HIS), Radiology Information System (RIS) or PACS requires certain basic ingredients from Health Level 7 (HL7) standard for textual data, Digital Imaging and Communications in Medicine (DICOM) standard for images, and Integrating the Healthcare Enterprise (IHE) workflow profiles in order to comply with the Health Insurance Portability and Accountability Act (HIPAA) requirements to be a healthcare information system. Among the DICOM standards and IHE workflow profiles, DICOM Structured Reporting (DICOM-SR); and IHE Key Image Note (KIN), Simple Image and Numeric Report (SINR) and Post-processing Work Flow (PWF) are utilized in CAD-HIS/RIS/PACS integration. These topics with examples are presented in this chapter.

  13. Computer-Aided Modeling of Lipid Processing Technology

    DEFF Research Database (Denmark)

    Diaz Tovar, Carlos Axel

    2011-01-01

    the analysis, in terms of their design variables and their impact in the process behavior, of three lipid-related processes has been performed: the solvent recovery section of the extraction of crude soybean oil, the deodorization of palm oil, and the deacidification of soybean oil.......Vegetable oils and fats have an important role in human nutrition and in the chemical industry since they are a source of energy, fat-soluble vitamins, and now also in the production of renewable sources of energy. Nowadays as the consumer preferences for natural products and healthier foods...... increase along with growing interest in biofuels, the oleochemical industry faces in the upcoming years major challenges in terms of design and development of better products and more sustainable processes to make them. Computer-aided methods and tools for process synthesis, modeling and simulation...

  14. Decision trees and integrated features for computer aided mammographic screening

    Energy Technology Data Exchange (ETDEWEB)

    Kegelmeyer, W.P. Jr.; Groshong, B.; Allmen, M.; Woods, K.

    1997-02-01

    Breast cancer is a serious problem, which in the United States causes 43,000 deaths a year, eventually striking 1 in 9 women. Early detection is the only effective countermeasure, and mass mammography screening is the only reliable means for early detection. Mass screening has many shortcomings which could be addressed by a computer-aided mammographic screening system. Accordingly, we have applied the pattern recognition methods developed in earlier investigations of speculated lesions in mammograms to the detection of microcalcifications and circumscribed masses, generating new, more rigorous and uniform methods for the detection of both those signs. We have also improved the pattern recognition methods themselves, through the development of a new approach to combinations of multiple classifiers.

  15. A Computer-Aided Detection System for Digital Chest Radiographs

    Directory of Open Access Journals (Sweden)

    Juan Manuel Carrillo-de-Gea

    2016-01-01

    Full Text Available Computer-aided detection systems aim at the automatic detection of diseases using different medical imaging modalities. In this paper, a novel approach to detecting normality/pathology in digital chest radiographs is proposed. The problem tackled is complicated since it is not focused on particular diseases but anything that differs from what is considered as normality. First, the areas of interest of the chest are found using template matching on the images. Then, a texture descriptor called local binary patterns (LBP is computed for those areas. After that, LBP histograms are applied in a classifier algorithm, which produces the final normality/pathology decision. Our experimental results show the feasibility of the proposal, with success rates above 87% in the best cases. Moreover, our technique is able to locate the possible areas of pathology in nonnormal radiographs. Strengths and limitations of the proposed approach are described in the Conclusions.

  16. Peer Feedback in Computer Aided College English Writing Instruction

    Directory of Open Access Journals (Sweden)

    Ma Zhuo

    2016-01-01

    Full Text Available This study is to examine the acceptability of peer feedback in computer aided college English writing instruction. For the whole writing procedure, subjects in language labs were to take preparation, writing and evaluation stages, undergoing three editions suggested by peer feedbacks. For the first time reading, peers would comment on such general scale as subject and content of drafts, and the second focuses on specific items, for example the morphological, lexical and syntactical aspects, etc. To compare students’ attitudes towards the trial, before and after the experiment, Pre-Questionnaire and Post-Questionnaire were adopted to analyze differences. From the frequency of students’ views on ten statements, it is drawn that majority of subjects accept and enjoy the innovative writing process, since peer feedback is an essential and encouraging part for writing.

  17. The Computer Aided Aircraft-design Package (CAAP)

    Science.gov (United States)

    Yalif, Guy U.

    1994-01-01

    The preliminary design of an aircraft is a complex, labor-intensive, and creative process. Since the 1970's, many computer programs have been written to help automate preliminary airplane design. Time and resource analyses have identified, 'a substantial decrease in project duration with the introduction of an automated design capability'. Proof-of-concept studies have been completed which establish 'a foundation for a computer-based airframe design capability', Unfortunately, today's design codes exist in many different languages on many, often expensive, hardware platforms. Through the use of a module-based system architecture, the Computer aided Aircraft-design Package (CAAP) will eventually bring together many of the most useful features of existing programs. Through the use of an expert system, it will add an additional feature that could be described as indispensable to entry level engineers and students: the incorporation of 'expert' knowledge into the automated design process.

  18. Automatic computer-aided system of simulating solder joint formation

    Science.gov (United States)

    Zhao, Xiujuan; Wang, Chunqing; Zheng, Guanqun; Wang, Gouzhong; Yang, Shiqin

    1999-08-01

    One critical aspect in electronic packaging is the fatigue/creep-induced failure in solder interconnections, which is found to be highly dependent on the shape of solder joints. Thus predicting and analyzing the solder joint shape is warranted. In this paper, an automatic computer-aided system is developed to simulate the formation of solder joint and analyze the influence of the different process parameters on the solder joint shape. The developed system is capable of visually designing the process parameters and calculating the solder joint shape automatically without any intervention from the user. The automation achieved will enable fast shape estimation with the variation of process parameters without time consuming experiments, and the simulating system provides the design and manufacturing engineers an efficient software tools to design soldering process in design environment. Moreover, a program developed from the system can serve as the preprocessor for subsequent finite element joint analysis program.

  19. Computer-Aided Training and Quality Assessment of Creative Abilities

    Directory of Open Access Journals (Sweden)

    V. P. Pechnikov

    2015-01-01

    Full Text Available The article describes the training program that takes into account the laws of human mental activity. The peculiarity of this training is that it enables specialists to generate additional intellectual potentials. This potentials relate to various kinds of illogical (intuitive and hybrid (human-machine intelligences that are associated with the quality of professional and creative activity in future. Progress in trans-phenomenal functional systems of the brain is possible by means of special procedures and computer-based training programs.The article offers a logical system of computer-aided training. This system repeatedly compares its input and output data and uses a feedback as the innate human characteristic to obtain the final result.Computer-aided training can be implemented in analog and numeric form. The article deals with the numeric widely used MS Excel-based software. It provides tabular and graphic style visualization desirable for training.A specific technical program is used for training. It allows specialists to develop a reinforcement shell of square cell type of minimal weight. In designing various constraints can be considered.On the main page of MS Excel program there are input data tables, various forms of the cell, methods of its manufacturing, and a scale table. Coefficients needed for calculations are in the next tables. The next tables contain also technological and design limitations. The basic table enables us to vary the geometric complexes of the reinforcement shell. Using the tabular and graphical results of calculations an operator can define values of further steps (iterations. The operator’s aim is to design the shell of minimum weight for the shortest time or number of steps. There is number of counters using macros in the MS Excel tables to calculate the number of past iterations.

  20. Computer aided analysis, simulation and optimisation of thermal sterilisation processes.

    Science.gov (United States)

    Narayanan, C M; Banerjee, Arindam

    2013-04-01

    Although thermal sterilisation is a widely employed industrial process, little work is reported in the available literature including patents on the mathematical analysis and simulation of these processes. In the present work, software packages have been developed for computer aided optimum design of thermal sterilisation processes. Systems involving steam sparging, jacketed heating/cooling, helical coils submerged in agitated vessels and systems that employ external heat exchangers (double pipe, shell and tube and plate exchangers) have been considered. Both batch and continuous operations have been analysed and simulated. The dependence of del factor on system / operating parameters such as mass or volume of substrate to be sterilised per batch, speed of agitation, helix diameter, substrate to steam ratio, rate of substrate circulation through heat exchanger and that through holding tube have been analysed separately for each mode of sterilisation. Axial dispersion in the holding tube has also been adequately accounted for through an appropriately defined axial dispersion coefficient. The effect of exchanger characteristics/specifications on the system performance has also been analysed. The multiparameter computer aided design (CAD) software packages prepared are thus highly versatile in nature and they permit to make the most optimum choice of operating variables for the processes selected. The computed results have been compared with extensive data collected from a number of industries (distilleries, food processing and pharmaceutical industries) and pilot plants and satisfactory agreement has been observed between the two, thereby ascertaining the accuracy of the CAD softwares developed. No simplifying assumptions have been made during the analysis and the design of associated heating / cooling equipment has been performed utilising the most updated design correlations and computer softwares.

  1. The application of computer-aided technologies in automotive styling design

    Science.gov (United States)

    Zheng, Ze-feng; Zhang, Ji; Zheng, Ying

    2012-04-01

    In automotive industry, outline design is its life and creative design is its soul indeed. Computer-aided technology has been widely used in the automotive industry and more and more attention has been paid. This paper chiefly introduce the application of computer-aided technologies including CAD, CAM and CAE, analyses the process of automotive structural design and describe the development tendency of computer-aided design.

  2. Converting Between PLY and Ballistic Research Laboratory-Computer-Aided Design (BRL-CAD) File Formats

    Science.gov (United States)

    2015-02-01

    Converting Between PLY and Ballistic Research Laboratory–Computer-Aided Design (BRL- CAD ) File Formats by Rishub Jain ARL-CR-0760...0760 February 2015 Converting Between PLY and Ballistic Research Laboratory–Computer-Aided Design (BRL- CAD ) File Formats Rishub Jain US...and Ballistic Research Laboratory–Computer-Aided Design (BRL- CAD ) File Formats 5a. CONTRACT NUMBER W911NF-10-2-0076 5b. GRANT NUMBER 5c. PROGRAM

  3. Target Impact Detection Algorithm Using Computer-aided Design (CAD) Model Geometry

    Science.gov (United States)

    2014-09-01

    UNCLASSIFIED AD-E403 558 Technical Report ARMET-TR-13024 TARGET IMPACT DETECTION ALGORITHM USING COMPUTER-AIDED DESIGN ( CAD ...DETECTION ALGORITHM USING COMPUTER-AIDED DESIGN ( CAD ) MODEL GEOMETRY 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...This report documents a method and algorithm to export geometry from a three-dimensional, computer-aided design ( CAD ) model in a format that can be

  4. A computer-aided molecular design framework for crystallization solvent design

    DEFF Research Database (Denmark)

    Karunanithi, Arunprakash T.; Achenie, Luke E.K.; Gani, Rafiqul

    2006-01-01

    One of the key decisions in designing solution crystallization processes is the selection of solvents. In this paper, we present a computer-aided molecular design (CAMD) framework for the design and selection of solvents and/or anti-solvents for solution crystallization. The CAMD problem......, property requirements such as solubility, crystal morphology, flashpoint, toxicity, viscosity, normal boiling and melting point are posed as constraints. All the properties are estimated using group contribution methods. The MINLP model is then solved using a decomposition approach to obtain optimal...... solvent molecules. Solvent design and selection for two types of solution crystallization processes namely cooling crystallization and drowning out crystallization are presented. In the first case study, the design of single compound solvent for crystallization of ibuprofen, which is an important...

  5. Computer aided identification of the Ficus L. species by the lamina shape

    Directory of Open Access Journals (Sweden)

    Alexander Z. Gluhov

    2014-04-01

    Full Text Available The development of computer aided plant species determination is the urgent task of the botanical science. Identification is often bases on the morphology of the lamina. It is promising to describe the leaf shapes through the harmonic values of elliptic Fourier decomposition, but the effectiveness of this approach requires further verification. Another task is a comparative evaluation of different classification algorithms. The work was conducted on the 2812 leaves images of the 15 Ficus L. species. To solve the described tasks the optimal set of the Fourier decomposition parameters was determined. The best results are achievable by using the classification with 18 Fourier harmonics. Number of reference points on the outline does not affect the result of the models. We compared an identification accuracy of the 30 classification algorithms. Random forest algorithm had the highest classification accuracy – 98%. Combining different prediction algorithms by stacking improves the efficiency of the leaf shapes recognition.

  6. Organ printing: computer-aided jet-based 3D tissue engineering.

    Science.gov (United States)

    Mironov, Vladimir; Boland, Thomas; Trusk, Thomas; Forgacs, Gabor; Markwald, Roger R

    2003-04-01

    Tissue engineering technology promises to solve the organ transplantation crisis. However, assembly of vascularized 3D soft organs remains a big challenge. Organ printing, which we define as computer-aided, jet-based 3D tissue-engineering of living human organs, offers a possible solution. Organ printing involves three sequential steps: pre-processing or development of "blueprints" for organs; processing or actual organ printing; and postprocessing or organ conditioning and accelerated organ maturation. A cell printer that can print gels, single cells and cell aggregates has been developed. Layer-by-layer sequentially placed and solidified thin layers of a thermo-reversible gel could serve as "printing paper". Combination of an engineering approach with the developmental biology concept of embryonic tissue fluidity enables the creation of a new rapid prototyping 3D organ printing technology, which will dramatically accelerate and optimize tissue and organ assembly.

  7. Multidisciplinary design optimization of adaptive wing leading edge

    Institute of Scientific and Technical Information of China (English)

    SUN; RuJie; CHEN; GuoPing; ZHOU; Chen; ZHOU; LanWei; JIANG; JinHui

    2013-01-01

    Adaptive wing can significantly enhance aircraft aerodynamic performance, which refers to aerodynamic and structural opti-mization designs. This paper introduces a two-step approach to solve the interrelated problems of the adaptive leading edge. In the first step, the procedure of airfoil optimization is carried out with an initial configuration of NACA 0006. On the basis of the combination of design of experiment (DOE), response surface method (RSM) and genetic algorithm (GA), an adaptive air-foil can be obtained whose lift-to-drag ratio is larger than the baseline airfoil’s at the given angle of attack and subsonic speed.The next step is to design a compliant structure to achieve the target airfoil shape, which is the optimization result of the previous step. In order to minimize the deviation of the deformed shape from the target shape, the load path representation topology method is presented. This method is developed by way of GA, with size and shape optimization incorporated in it simul-taneously. Finally, a comparison study with the Solid Isotropic Material with Penalization (SIMP) method in Altair OptiStruct is conducted, and the results demonstrate the validity and effectiveness of the proposed approach.

  8. Efficient and effective compound management to support lead optimization.

    Science.gov (United States)

    Johnson, Chad W; Chatterjee, Moneesh; Kubala, Steve; Helm, David; Houston, John; Banks, Martyn

    2009-06-01

    The introduction of lean thinking and Six Sigma methodologies into the drug discovery process has become an important approach for ensuring efficient workflows while containing costs. For the compound management department at Bristol-Myers Squibb, this has resulted in a partnership with the research community to evaluate and streamline processes to enable cost-disciplined science. The authors describe the results of Lean Six Sigma approaches in the automation and informatics environment that have been optimized to support parallel processing of compounds. This new platform facilitates the rapid and simultaneous data generation from structure activity and structure liability assays. As a result of these compound management improvements, reduction of timelines and quicker decision making has been achieved in the lead optimization process.

  9. Fracture resistance of computer-aided design/computer-aided manufacturing-generated composite resin-based molar crowns.

    Science.gov (United States)

    Harada, Akio; Nakamura, Keisuke; Kanno, Taro; Inagaki, Ryoichi; Örtengren, Ulf; Niwano, Yoshimi; Sasaki, Keiichi; Egusa, Hiroshi

    2015-04-01

    The aim of this study was to investigate whether different fabrication processes, such as the computer-aided design/computer-aided manufacturing (CAD/CAM) system or the manual build-up technique, affect the fracture resistance of composite resin-based crowns. Lava Ultimate (LU), Estenia C&B (EC&B), and lithium disilicate glass-ceramic IPS e.max press (EMP) were used. Four types of molar crowns were fabricated: CAD/CAM-generated composite resin-based crowns (LU crowns); manually built-up monolayer composite resin-based crowns (EC&B-monolayer crowns); manually built-up layered composite resin-based crowns (EC&B-layered crowns); and EMP crowns. Each type of crown was cemented to dies and the fracture resistance was tested. EC&B-layered crowns showed significantly lower fracture resistance compared with LU and EMP crowns, although there was no significant difference in flexural strength or fracture toughness between LU and EC&B materials. Micro-computed tomography and fractographic analysis showed that decreased strength probably resulted from internal voids in the EC&B-layered crowns introduced by the layering process. There was no significant difference in fracture resistance among LU, EC&B-monolayer, and EMP crowns. Both types of composite resin-based crowns showed fracture loads of >2000 N, which is higher than the molar bite force. Therefore, CAD/CAM-generated crowns, without internal defects, may be applied to molar regions with sufficient fracture resistance. © 2015 Eur J Oral Sci.

  10. Micrometric precision of prosthetic dental crowns obtained by optical scanning and computer-aided designing/computer-aided manufacturing system

    Science.gov (United States)

    das Neves, Flávio Domingues; de Almeida Prado Naves Carneiro, Thiago; do Prado, Célio Jesus; Prudente, Marcel Santana; Zancopé, Karla; Davi, Letícia Resende; Mendonça, Gustavo; Soares, Carlos José

    2014-08-01

    The current study evaluated prosthetic dental crowns obtained by optical scanning and a computer-aided designing/computer-aided manufacturing system using micro-computed tomography to compare the marginal fit. The virtual models were obtained with four different scanning surfaces: typodont (T), regular impressions (RI), master casts (MC), and powdered master casts (PMC). Five virtual models were obtained for each group. For each model, a crown was designed on the software and milled from feldspathic ceramic blocks. Micro-CT images were obtained for marginal gap measurements and the data were statistically analyzed by one-way analysis of variance followed by Tukey's test. The mean vertical misfit was T=62.6±65.2 μm; MC=60.4±38.4 μm; PMC=58.1±38.0 μm, and RI=89.8±62.8 μm. Considering a percentage of vertical marginal gap of up to 75 μm, the results were T=71.5%, RI=49.2%, MC=69.6%, and PMC=71.2%. The percentages of horizontal overextension were T=8.5%, RI=0%, MC=0.8%, and PMC=3.8%. Based on the results, virtual model acquisition by scanning the typodont (simulated mouth) or MC, with or without powder, showed acceptable values for the marginal gap. The higher result of marginal gap of the RI group suggests that it is preferable to scan this directly from the mouth or from MC.

  11. Optical tomographic detection of rheumatoid arthritis with computer-aided classification schemes

    Science.gov (United States)

    Klose, Christian D.; Klose, Alexander D.; Netz, Uwe; Beuthan, Jürgen; Hielscher, Andreas H.

    2009-02-01

    A recent research study has shown that combining multiple parameters, drawn from optical tomographic images, leads to better classification results to identifying human finger joints that are affected or not affected by rheumatic arthritis RA. Building up on the research findings of the previous study, this article presents an advanced computer-aided classification approach for interpreting optical image data to detect RA in finger joints. Additional data are used including, for example, maximum and minimum values of the absorption coefficient as well as their ratios and image variances. Classification performances obtained by the proposed method were evaluated in terms of sensitivity, specificity, Youden index and area under the curve AUC. Results were compared to different benchmarks ("gold standard"): magnet resonance, ultrasound and clinical evaluation. Maximum accuracies (AUC=0.88) were reached when combining minimum/maximum-ratios and image variances and using ultrasound as gold standard.

  12. Dynamic light as a transformational tool in computer-aided design

    DEFF Research Database (Denmark)

    Hansen, Ellen Kathrine; Mullins, Michael Finbarr; Triantafyllidis, Georgios

    2016-01-01

    , the process and tools can be grouped in the following five domains: 1. Transfer. Knowledge from different disciplines is collected, transferred, reviewed and coded into a common language. 2. Translate. The knowledge from the different fields is translated and investigated through experiments. Rapid prototype...... to develop mixed research and design methods, where computer aided design tools used in physical and virtual experiments assist the transdisciplinary design process. The task is to discover a sequence of processes and tools that support each other and lead to innovative design solutions produced from...... as a transformational design tool is perhaps one of the most non-destructive, reversible and gentle ways to transform and redefine architecture and spaces. The case studied is a particular urban and architectural challenge represented by an urban church building, which had fallen into disuse. The building was acquired...

  13. Computer aided diagnosis of osteoporosis using multi-slice CT images

    Science.gov (United States)

    Takahashi, Eiji; Saita, Shinsuke; Kawata, Yoshiki; Niki, Noboru; Ito, Masako; Nishitani, Hiromu; Moriyama, Noriyuki

    2010-03-01

    The patients of osteoporosis comprised about 11 million people in Japan and it is one of the problems the aging society has. In order to prevent the osteoporosis, it is necessary to do early detection and treatment. The development of Multislice CT technology made it possible to perform the three dimensional (3-D) image analysis with higher body axis resolution and shorter scan time. The 3-D image analysis using multi-slice CT images of thoracic vertebra can be used as a support to diagnose osteoporosis and at the same time can be used for lung cancer screening which may lead to its early detection. We develop an automatic extraction algorithm of vertebra, and the analysis algorithm of the vertebral body using shape analysis and a bone density measurement for the computer aided diagnosis of osteoporosis.

  14. Potent new small-molecule inhibitor of botulinum neurotoxin serotype A endopeptidase developed by synthesis-based computer-aided molecular design.

    Directory of Open Access Journals (Sweden)

    Yuan-Ping Pang

    Full Text Available Botulinum neurotoxin serotype A (BoNTA causes a life-threatening neuroparalytic disease known as botulism. Current treatment for post exposure of BoNTA uses antibodies that are effective in neutralizing the extracellular toxin to prevent further intoxication but generally cannot rescue already intoxicated neurons. Effective small-molecule inhibitors of BoNTA endopeptidase (BoNTAe are desirable because such inhibitors potentially can neutralize the intracellular BoNTA and offer complementary treatment for botulism. Previously we reported a serotype-selective, small-molecule BoNTAe inhibitor with a K(i (app value of 3.8+/-0.8 microM. This inhibitor was developed by lead identification using virtual screening followed by computer-aided optimization of a lead with an IC(50 value of 100 microM. However, it was difficult to further improve the lead from micromolar to even high nanomolar potency due to the unusually large enzyme-substrate interface of BoNTAe. The enzyme-substrate interface area of 4,840 A(2 for BoNTAe is about four times larger than the typical protein-protein interface area of 750-1,500 A(2. Inhibitors must carry several functional groups to block the unusually large interface of BoNTAe, and syntheses of such inhibitors are therefore time-consuming and expensive. Herein we report the development of a serotype-selective, small-molecule, and competitive inhibitor of BoNTAe with a K(i value of 760+/-170 nM using synthesis-based computer-aided molecular design (SBCAMD. This new approach accounts the practicality and efficiency of inhibitor synthesis in addition to binding affinity and selectivity. We also report a three-dimensional model of BoNTAe in complex with the new inhibitor and the dynamics of the complex predicted by multiple molecular dynamics simulations, and discuss further structural optimization to achieve better in vivo efficacy in neutralizing BoNTA than those of our early micromolar leads. This work provides new insight

  15. An Intelligent Master Model of Computer Aided Process Planning for Large Complicated Stampings

    Institute of Scientific and Technical Information of China (English)

    Zheng Jinqiao; Wang Yilin; Li Zhigang

    2005-01-01

    Process planning for large complicated stampings is more complicated, illegible and multiform than that for common stampings.In this paper, an intelligent master model of computer aided process planning (CAPP) for large complicated stampings has been developed based on knowledge based engineering (KBE) and feature technology. This innovative model consists of knowledge base ( KB), process control structure (PCS), process information model (PIM), multidisciplinary design optimization (MDO), model link environment (MLE) and simulation engine (SE), to realize process planning, optimization, simulation and management integrated to complete intelligent CAPP system. In this model, KBE provides knowledge base, open architecture and knowledge reuse ability to deal with the multi-domain and multi-expression of process knowledge, and forms an integrated environment. With PIM,all the knowledge consisting of objects, constraints, experience and decision-makings is carried by object-oriented method dynamically for knowledge-reasoning. PCS makes dynamical knowledge modified and updated timely and accordingly. MLE provides sev eral methods to make CAPP system associated and integrated. SE provides a programmable mechanism to interpret simulation course and result. Meanwhile, collaborative optimization, one method of MDO, is imported to deal with the optimization distributed for multiple purposes. All these make CAPP system integrated and open to other systems, such as die design and manufacturing system.

  16. Teaching Computer-Aided Design of Fluid Flow and Heat Transfer Engineering Equipment.

    Science.gov (United States)

    Gosman, A. D.; And Others

    1979-01-01

    Describes a teaching program for fluid mechanics and heat transfer which contains both computer aided learning (CAL) and computer aided design (CAD) components and argues that the understanding of the physical and numerical modeling taught in the CAL course is essential to the proper implementation of CAD. (Author/CMV)

  17. [The automatic iris map overlap technology in computer-aided iridiagnosis].

    Science.gov (United States)

    He, Jia-feng; Ye, Hu-nian; Ye, Miao-yuan

    2002-11-01

    In the paper, iridology and computer-aided iridiagnosis technologies are briefly introduced and the extraction method of the collarette contour is then investigated. The iris map can be overlapped on the original iris image based on collarette contour extraction. The research on collarette contour extraction and iris map overlap is of great importance to computer-aided iridiagnosis technologies.

  18. Computer-aided Diagnosis: How to Move from the Laboratory to the Clinic.

    NARCIS (Netherlands)

    Ginneken, B. van; Schaefer-Prokop, C.M.; Prokop, M.

    2011-01-01

    Computer-aided diagnosis (CAD), encompassing computer-aided detection and quantification, is an established and rapidly growing field of research. In daily practice, however, most radiologists do not yet use CAD routinely. This article discusses how to move CAD from the laboratory to the clinic. The

  19. Enabling Lean Design Through Computer Aided Synthesis: The Injection Moulding Cooling Case

    NARCIS (Netherlands)

    Jauregui Becker, Juan M.; Wits, Wessel W.

    2015-01-01

    This paper explores the application of Computer Aided Synthesis (CAS) to support the implementation of Set-Based Concurrent Engineering (SBCE) and Just In Time Decision Making (JIT-DM), which are considered as two of the cornerstones of the Lean Design method. Computer Aided Synthesis refers to a ne

  20. XPLANE, a Generative Computer Aided Process Planning System for Part Manufacturing

    NARCIS (Netherlands)

    Erve, van 't A.H.

    1986-01-01

    This paper reports on the development of XPLANE, a generative computer aided process planning system for part manufacturing. Described is its position and functioning as a part of a more extended computer aided manufacturing system that includes a link to CAD systems, as well as systems for computer

  1. CART V: recent advancements in computer-aided camouflage assessment

    Science.gov (United States)

    Müller, Thomas; Müller, Markus

    2011-05-01

    In order to facilitate systematic, computer aided improvements of camouflage and concealment assessment methods, the software system CART (Camouflage Assessment in Real-Time) was built up for the camouflage assessment of objects in multispectral image sequences (see contributions to SPIE 2007-2010 [1], [2], [3], [4]). It comprises a semi-automatic marking of target objects (ground truth generation) including their propagation over the image sequence and the evaluation via user-defined feature extractors as well as methods to assess the object's movement conspicuity. In this fifth part in an annual series at the SPIE conference in Orlando, this paper presents the enhancements over the recent year and addresses the camouflage assessment of static and moving objects in multispectral image data that can show noise or image artefacts. The presented methods fathom the correlations between image processing and camouflage assessment. A novel algorithm is presented based on template matching to assess the structural inconspicuity of an object objectively and quantitatively. The results can easily be combined with an MTI (moving target indication) based movement conspicuity assessment function in order to explore the influence of object movement to a camouflage effect in different environments. As the results show, the presented methods contribute to a significant benefit in the field of camouflage assessment.

  2. Electromagnetic tracking for abdominal interventions in computer aided surgery.

    Science.gov (United States)

    Zhang, Hui; Banovac, Filip; Lin, Ralph; Glossop, Neil; Wood, Bradford J; Lindisch, David; Levy, Elliot; Cleary, Kevin

    2006-05-01

    Electromagnetic tracking has great potential for assisting physicians in precision placement of instruments during minimally invasive interventions in the abdomen, since electromagnetic tracking is not limited by the line-of-sight restrictions of optical tracking. A new generation of electromagnetic tracking has recently become available, with sensors small enough to be included in the tips of instruments. To fully exploit the potential of this technology, our research group has been developing a computer aided, image-guided system that uses electromagnetic tracking for visualization of the internal anatomy during abdominal interventions. As registration is a critical component in developing an accurate image-guided system, we present three registration techniques: 1) enhanced paired-point registration (time-stamp match registration and dynamic registration); 2) orientation-based registration; and 3) needle shape-based registration. Respiration compensation is another important issue, particularly in the abdomen, where respiratory motion can make precise targeting difficult. To address this problem, we propose reference tracking and affine transformation methods. Finally, we present our prototype navigation system, which integrates the registration, segmentation, path-planning and navigation functions to provide real-time image guidance in the clinical environment. The methods presented here have been tested with a respiratory phantom specially designed by our group and in swine animal studies under approved protocols. Based on these tests, we conclude that our system can provide quick and accurate localization of tracked instruments in abdominal interventions, and that it offers a user-friendly display for the physician.

  3. Computer-Aided Vaccine Design: A Brief Report

    Directory of Open Access Journals (Sweden)

    R Ghasemi Khorasgani

    2012-09-01

    Full Text Available Background: Although the conventional vaccines have been instrumented in the incidence of many infectious diseases, the advances in genetic engineering and bioinformatics have provided the opportunity for developing improved and new vaccines.Methods: Reverse vaccinology was pioneered by a group of researchers investigating development of a vaccine against serogroup B Neisseria meningitidis. Reverse vaccinology analyzes the entire genome of a pathogen with the aid of computational programs to identify potentially antigenic extracellular proteins.Results: Using this method for Neisseria meningitidis genome analysis, 600 secretory or surface-exposed proteins were identified and, subsequently, 350 proteins were expressed and purified. Finally, seven proteins capable of activating the immune system against a range of strains were identified.Conclusion: Improved computational techniques are now able to provide researchers with high-confidence predictions for complex biological characteristics. This will herald a move to computer-aided biotechnology in which time-consuming and expensive large-scale experimental approaches are progressively replaced by functional bioinformatic investigations.

  4. ARCHITECTURE OF WEB BASED COMPUTER-AIDED MANUFACTURING SYSTEM

    Directory of Open Access Journals (Sweden)

    N. E. Filyukov

    2014-09-01

    Full Text Available The paper deals with design of a web-based system for Computer-Aided Manufacturing (CAM. Remote applications and databases located in the "private cloud" are proposed to be the basis of such system. The suggested approach contains: service - oriented architecture, using web applications and web services as modules, multi-agent technologies for implementation of information exchange functions between the components of the system and the usage of PDM - system for managing technology projects within the CAM. The proposed architecture involves CAM conversion into the corporate information system that will provide coordinated functioning of subsystems based on a common information space, as well as parallelize collective work on technology projects and be able to provide effective control of production planning. A system has been developed within this architecture which gives the possibility for a rather simple technological subsystems connect to the system and implementation of their interaction. The system makes it possible to produce CAM configuration for a particular company on the set of developed subsystems and databases specifying appropriate access rights for employees of the company. The proposed approach simplifies maintenance of software and information support for CAM subsystems due to their central location in the data center. The results can be used as a basis for CAM design and testing within the learning process for development and modernization of the system algorithms, and then can be tested in the extended enterprise.

  5. A digital patient for computer-aided prosthesis design.

    Science.gov (United States)

    Colombo, Giorgio; Facoetti, Giancarlo; Rizzi, Caterina

    2013-04-06

    This article concerns the design of lower limb prosthesis, both below and above knee. It describes a new computer-based design framework and a digital model of the patient around which the prosthesis is designed and tested in a completely virtual environment. The virtual model of the patient is the backbone of the whole system, and it is based on a biomechanical general-purpose model customized with the patient's characteristics (e.g. anthropometric measures). The software platform adopts computer-aided and knowledge-guided approaches with the goal of replacing the current development process, mainly hand made, with a virtual one. It provides the prosthetics with a set of tools to design, configure and test the prosthesis and comprehends two main environments: the prosthesis modelling laboratory and the virtual testing laboratory. The first permits the three-dimensional model of the prosthesis to be configured and generated, while the second allows the prosthetics to virtually set up the artificial leg and simulate the patient's postures and movements, validating its functionality and configuration. General architecture and modelling/simulation tools for the platform are described as well as main aspects and results of the experimentation.

  6. Computer aided polymer design using multi-scale modelling

    Directory of Open Access Journals (Sweden)

    K. C. Satyanarayana

    2010-09-01

    Full Text Available The ability to predict the key physical and chemical properties of polymeric materials from their repeat-unit structure and chain-length architecture prior to synthesis is of great value for the design of polymer-based chemical products, with new functionalities and improved performance. Computer aided molecular design (CAMD methods can expedite the design process by establishing input-output relations between the type and number of functional groups in a polymer repeat unit and the desired macroscopic properties. A multi-scale model-based approach that combines a CAMD technique based on group contribution plus models for predicting polymer repeat unit properties with atomistic simulations for providing first-principles arrangements of the repeat units and for predictions of physical properties of the chosen candidate polymer structures, has been developed and tested for design of polymers with desired properties. A case study is used to highlight the main features of this multi-scale model-based approach for the design of a polymer-based product.

  7. The future of computer-aided sperm analysis

    Directory of Open Access Journals (Sweden)

    Sharon T Mortimer

    2015-01-01

    Full Text Available Computer-aided sperm analysis (CASA technology was developed in the late 1980s for analyzing sperm movement characteristics or kinematics and has been highly successful in enabling this field of research. CASA has also been used with great success for measuring semen characteristics such as sperm concentration and proportions of progressive motility in many animal species, including wide application in domesticated animal production laboratories and reproductive toxicology. However, attempts to use CASA for human clinical semen analysis have largely met with poor success due to the inherent difficulties presented by many human semen samples caused by sperm clumping and heavy background debris that, until now, have precluded accurate digital image analysis. The authors review the improved capabilities of two modern CASA platforms (Hamilton Thorne CASA-II and Microptic SCA6 and consider their current and future applications with particular reference to directing our focus towards using this technology to assess functional rather than simple descriptive characteristics of spermatozoa. Specific requirements for validating CASA technology as a semi-automated system for human semen analysis are also provided, with particular reference to the accuracy and uncertainty of measurement expected of a robust medical laboratory test for implementation in clinical laboratories operating according to modern accreditation standards.

  8. Orthodontics: computer-aided diagnosis and treatment planning

    Science.gov (United States)

    Yi, Yaxing; Li, Zhongke; Wei, Suyuan; Deng, Fanglin; Yao, Sen

    2000-10-01

    The purpose of this article is to introduce the outline of our newly developed computer-aided 3D dental cast analyzing system with laser scanning, and its preliminary clinical applications. The system is composed of a scanning device and a personal computer as a scanning controller and post processor. The scanning device is composed of a laser beam emitter, two sets of linear CCD cameras and a table which is rotatable by two-degree-of-freedom. The rotating is controlled precisely by a personal computer. The dental cast is projected and scanned with a laser beam. Triangulation is applied to determine the location of each point. Generation of 3D graphics of the dental cast takes approximately 40 minutes. About 170,000 sets of X,Y,Z coordinates are store for one dental cast. Besides the conventional linear and angular measurements of the dental cast, we are also able to demonstrate the size of the top surface area of each molar. The advantage of this system is that it facilitates the otherwise complicated and time- consuming mock surgery necessary for treatment planning in orthognathic surgery.

  9. COMPUTER-AIDED DETECTION OF ACINAR SHADOWS IN CHEST RADIOGRAPHS

    Directory of Open Access Journals (Sweden)

    Tao Xu

    2013-05-01

    Full Text Available Despite the technological advances in medical diagnosis, accurate detection of infectious tuberculosis (TB still poses challenges due to complex image features and thus infectious TB continues to be a public health problem of global proportions. Currently, the detection of TB is mainly conducted visually by radiologists examining chest radiographs (CXRs. To reduce the backlog of CXR examination and provide more precise quantitative assessment, computer-aided detection (CAD systems for potential lung lesions have been increasingly adopted and commercialized for clinical practice. CADs work as supporting tools to alert radiologists on suspected features that could have easily been neglected. In this paper, an effective CAD system aimed for acinar shadow regions detection in CXRs is proposed. This system exploits textural and photometric features analysis techniques which include local binary pattern (LBP, grey level co-occurrence matrix (GLCM and histogram of oriented gradients (HOG to analyze target regions in CXRs. Classification of acinar shadows using Adaboost is then deployed to verify the performance of a combination of these techniques. Comparative study in different image databases shows that the proposed CAD system delivers consistent high accuracy in detecting acinar shadows.

  10. Computer-Aided Experiment Planning toward Causal Discovery in Neuroscience.

    Science.gov (United States)

    Matiasz, Nicholas J; Wood, Justin; Wang, Wei; Silva, Alcino J; Hsu, William

    2017-01-01

    Computers help neuroscientists to analyze experimental results by automating the application of statistics; however, computer-aided experiment planning is far less common, due to a lack of similar quantitative formalisms for systematically assessing evidence and uncertainty. While ontologies and other Semantic Web resources help neuroscientists to assimilate required domain knowledge, experiment planning requires not only ontological but also epistemological (e.g., methodological) information regarding how knowledge was obtained. Here, we outline how epistemological principles and graphical representations of causality can be used to formalize experiment planning toward causal discovery. We outline two complementary approaches to experiment planning: one that quantifies evidence per the principles of convergence and consistency, and another that quantifies uncertainty using logical representations of constraints on causal structure. These approaches operationalize experiment planning as the search for an experiment that either maximizes evidence or minimizes uncertainty. Despite work in laboratory automation, humans must still plan experiments and will likely continue to do so for some time. There is thus a great need for experiment-planning frameworks that are not only amenable to machine computation but also useful as aids in human reasoning.

  11. A computer-aided diagnostic system for kidney disease

    Science.gov (United States)

    Jahantigh, Farzad Firouzi; Malmir, Behnam; Avilaq, Behzad Aslani

    2017-01-01

    Background Disease diagnosis is complicated since patients may demonstrate similar symptoms but physician may diagnose different diseases. There are a few number of investigations aimed to create a fuzzy expert system, as a computer aided system for disease diagnosis. Methods In this research, a cross-sectional descriptive study conducted in a kidney clinic in Tehran, Iran in 2012. Medical diagnosis fuzzy rules applied, and a set of symptoms related to the set of considered diseases defined. The input case to be diagnosed defined by assigning a fuzzy value to each symptom and then three physicians asked about each suspected diseases. Then comments of those three physicians summarized for each disease. The fuzzy inference applied to obtain a decision fuzzy set for each disease, and crisp decision values attained to determine the certainty of existence for each disease. Results Results indicated that, in the diagnosis of seven cases of kidney disease by examining 21 indicators using fuzzy expert system, kidney stone disease with 63% certainty was the most probable, renal tubular was at the lowest level with 15%, and other kidney diseases were at the other levels. The most remarkable finding of this study was that results of kidney disease diagnosis (e.g., kidney stone) via fuzzy expert system were fully compatible with those of kidney physicians. Conclusion The proposed fuzzy expert system is a valid, reliable, and flexible instrument to diagnose several typical input cases. The developed system decreases the effort of initial physical checking and manual feeding of input symptoms.

  12. Computer-Aided Sensor Development Focused on Security Issues

    Directory of Open Access Journals (Sweden)

    Andrzej Bialas

    2016-05-01

    Full Text Available The paper examines intelligent sensor and sensor system development according to the Common Criteria methodology, which is the basic security assurance methodology for IT products and systems. The paper presents how the development process can be supported by software tools, design patterns and knowledge engineering. The automation of this process brings cost-, quality-, and time-related advantages, because the most difficult and most laborious activities are software-supported and the design reusability is growing. The paper includes a short introduction to the Common Criteria methodology and its sensor-related applications. In the experimental section the computer-supported and patterns-based IT security development process is presented using the example of an intelligent methane detection sensor. This process is supported by an ontology-based tool for security modeling and analyses. The verified and justified models are transferred straight to the security target specification representing security requirements for the IT product. The novelty of the paper is to provide a patterns-based and computer-aided methodology for the sensors development with a view to achieving their IT security assurance. The paper summarizes the validation experiment focused on this methodology adapted for the sensors system development, and presents directions of future research.

  13. Computer aided lung cancer diagnosis with deep learning algorithms

    Science.gov (United States)

    Sun, Wenqing; Zheng, Bin; Qian, Wei

    2016-03-01

    Deep learning is considered as a popular and powerful method in pattern recognition and classification. However, there are not many deep structured applications used in medical imaging diagnosis area, because large dataset is not always available for medical images. In this study we tested the feasibility of using deep learning algorithms for lung cancer diagnosis with the cases from Lung Image Database Consortium (LIDC) database. The nodules on each computed tomography (CT) slice were segmented according to marks provided by the radiologists. After down sampling and rotating we acquired 174412 samples with 52 by 52 pixel each and the corresponding truth files. Three deep learning algorithms were designed and implemented, including Convolutional Neural Network (CNN), Deep Belief Networks (DBNs), Stacked Denoising Autoencoder (SDAE). To compare the performance of deep learning algorithms with traditional computer aided diagnosis (CADx) system, we designed a scheme with 28 image features and support vector machine. The accuracies of CNN, DBNs, and SDAE are 0.7976, 0.8119, and 0.7929, respectively; the accuracy of our designed traditional CADx is 0.7940, which is slightly lower than CNN and DBNs. We also noticed that the mislabeled nodules using DBNs are 4% larger than using traditional CADx, this might be resulting from down sampling process lost some size information of the nodules.

  14. Computer Aided Detection of SARS Based on Radiographs Data Mining.

    Science.gov (United States)

    Xuanyang, Xie; Yuchang, Gong; Shouhong, Wan; Xi, Li

    2005-01-01

    This paper introduces our work on how to use image mining techniques to detect SARS, the severe acute respiratory syndrome, automatically as the prototype of computer aided detection/diagnosis (CAD) system. Data used in this paper are digitalized PA(posterior anterior) X-ray images stored in the real-life picture archiving and communication system (PACS) of the 2nd Affiliation Hospital of Guangzhou Medical College. Association rule mining was applied first but results showed there was no significant difference between the locations of the lesions or infiltrate. Classification based on image textures was performed. A sample set contains both the pneumonia and SARS X-ray images was built in the first place. After modeling each sample by a feature vector, the sample set was partitioned to match the detection purpose: classification. Three methods were used: C4.5, neural network (NN) and CART. Final result shows that 70.94% SARS cases can be detected by CART. Data preparation, segmentation, feature extraction and data mining steps, with corresponding techniques are included in this paper. ROC charts and confusion matrix by all three methods are given and analyzed.

  15. Computer-Aided Sensor Development Focused on Security Issues.

    Science.gov (United States)

    Bialas, Andrzej

    2016-05-26

    The paper examines intelligent sensor and sensor system development according to the Common Criteria methodology, which is the basic security assurance methodology for IT products and systems. The paper presents how the development process can be supported by software tools, design patterns and knowledge engineering. The automation of this process brings cost-, quality-, and time-related advantages, because the most difficult and most laborious activities are software-supported and the design reusability is growing. The paper includes a short introduction to the Common Criteria methodology and its sensor-related applications. In the experimental section the computer-supported and patterns-based IT security development process is presented using the example of an intelligent methane detection sensor. This process is supported by an ontology-based tool for security modeling and analyses. The verified and justified models are transferred straight to the security target specification representing security requirements for the IT product. The novelty of the paper is to provide a patterns-based and computer-aided methodology for the sensors development with a view to achieving their IT security assurance. The paper summarizes the validation experiment focused on this methodology adapted for the sensors system development, and presents directions of future research.

  16. Computer-aided pattern classification system for dermoscopy images.

    Science.gov (United States)

    Abbas, Qaisar; Celebi, M Emre; Fondón, Irene

    2012-08-01

    Computer-aided pattern classification of melanoma and other pigmented skin lesions is one of the most important tasks for clinical diagnosis. To differentiate between benign and malignant lesions, the extraction of color, architectural order, symmetry of pattern and homogeneity (CASH) is a challenging task. In this article, a novel pattern classification system (PCS) based on the clinical CASH rule is presented to classify among six classes of patterns. The PCS system consists of the following five steps: transformation to the CIE L*a*b* color space, pre-processing to enhance the tumor region and removal of hairs, tumor-area segmentation, color and texture feature extraction, and finally, classification based on a multiclass support vector machine. The PCS system is tested on a total of 180 dermoscopic images. To test the performance of the PCS diagnostic classifier, the area under the receiver operating characteristics curve (AUC) is utilized. The proposed classifier achieved a sensitivity of 91.64%, specificity of 94.14%, and AUC of 0.948. The experimental results demonstrate that the proposed pattern classifier is highly accurate and classify between benign and malignant lesions into some extend. The PCS method is fully automatic and can accurately detect different patterns from dermoscopy images using color and texture properties. Additional pattern features can be included to investigate the impact of pattern classification based on the CASH rule. © 2011 John Wiley & Sons A/S.

  17. Computer-Aided Design of Nanocapsules for Therapeutic Delivery

    Directory of Open Access Journals (Sweden)

    Zeina Shreif

    2009-01-01

    Full Text Available The design of nanocapsules for targeted delivery of therapeutics presents many, often seemingly self-contradictory, constraints. An algorithm for predicting the physico-chemical characteristics of nanocapsule delivery and payload release using a novel all-atom, multiscale technique is presented. This computational method preserves key atomic-scale behaviours needed to make predictions of interactions of functionalized nanocapsules with the cell surface receptors, drug, siRNA, gene or other payload. We show how to introduce a variety of order parameters with distinct character to enable a multiscale analysis of a complex system. The all-atom formulation allows for the use of an interatomic force field, making the approach universal and avoiding recalibration with each new application. Alternatively, key parameters, which minimize the need for calibration, are also identified. Simultaneously, the methodology enables predictions of the supra-nanometer-scale behaviour, such as structural transitions and disassembly of the nanocapsule accompanying timed payload release or due to premature degradation. The final result is a Fokker–Planck equation governing the rate of stochastic payload release and structural changes and migration accompanying it. A novel “salt shaker” effect that underlies fluctuation-enhancement of payload delivery is presented. Prospects for computer-aided design of nanocapsule delivery system are discussed.

  18. The ultimate CASE (Computer-Aided Software Engineering) tool

    Energy Technology Data Exchange (ETDEWEB)

    Sharp, J.K.

    1990-01-01

    The theory and practice of information engineering is being actively developed at Sandia National Laboratories. The main output of Sandia is information. Information is created, analyzed and distributed. It is the life blood of our design laboratory. The proper management of information will have a large, positive impact on staff productivity. In order to achieve the potential benefits of shared information a commonly understood approach is needed, and the approach must be implemented in a CASE (Computer-Aided Software Engineering) tool that spans the entire life cycle of information. The commonly understood approach used at Sandia is natural language. More specifically, it is a structured subset of English. Users and system developers communicate requirements and commitments that they both understand. The approach is based upon NIAM (Nijssen's Information Analysis Methodology). In the last three years four NIAM training classes have been given at Sandia. The classes were all at the introductory level, with the latest class last October having an additional seminar highlighting successful projects. The continued growth in applications using NIAM requires an advanced class. The class will develop an information model for the Ultimate CASE Tool.'' This paper presents the requirements that have been established for the Ultimate CASE Tool'' and presents initial models. 4 refs., 1 tab.

  19. Computer-Aided Experiment Planning toward Causal Discovery in Neuroscience

    Science.gov (United States)

    Matiasz, Nicholas J.; Wood, Justin; Wang, Wei; Silva, Alcino J.; Hsu, William

    2017-01-01

    Computers help neuroscientists to analyze experimental results by automating the application of statistics; however, computer-aided experiment planning is far less common, due to a lack of similar quantitative formalisms for systematically assessing evidence and uncertainty. While ontologies and other Semantic Web resources help neuroscientists to assimilate required domain knowledge, experiment planning requires not only ontological but also epistemological (e.g., methodological) information regarding how knowledge was obtained. Here, we outline how epistemological principles and graphical representations of causality can be used to formalize experiment planning toward causal discovery. We outline two complementary approaches to experiment planning: one that quantifies evidence per the principles of convergence and consistency, and another that quantifies uncertainty using logical representations of constraints on causal structure. These approaches operationalize experiment planning as the search for an experiment that either maximizes evidence or minimizes uncertainty. Despite work in laboratory automation, humans must still plan experiments and will likely continue to do so for some time. There is thus a great need for experiment-planning frameworks that are not only amenable to machine computation but also useful as aids in human reasoning. PMID:28243197

  20. The promise of computer aided detection in digital mammography

    Energy Technology Data Exchange (ETDEWEB)

    Roehrig, Jimmy E-mail: jimmy@enrico.r2tech.com; Castellino, Ronald A. E-mail: castellr@mskcc.org

    1999-07-01

    Computer-aided detection (CAD) is a new technology now being implemented in many clinics to reduce the false negative rate in mammography screening. A large clinical study has been completed which shows that a substantial false negative (miss) rate exists in screening mammography, a significant fraction of the missed cancers are not subtle, and CAD has high sensitivity to these missed cancers. Full field digital mammography is now coming on the scene, but has not yet been proven in clinical practice. The authors believe that full acceptance of the new digital technology depends not merely on demonstrations of 'substantial equivalence' to film-screen technology, but rather on more complete exploitation of the unique advantages of digital technology, and that CAD can play a key role. These advantages derive from CAD's ability to quickly (in near real-time) perform analytical computations on digital information that is not readily available to the radiologist until after the cost of film-processing has occurred.

  1. Computer-aided pulmonary image analysis in small animal models

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Ziyue; Mansoor, Awais; Mollura, Daniel J. [Center for Infectious Disease Imaging (CIDI), Radiology and Imaging Sciences, National Institutes of Health (NIH), Bethesda, Maryland 32892 (United States); Bagci, Ulas, E-mail: ulasbagci@gmail.com [Center for Research in Computer Vision (CRCV), University of Central Florida (UCF), Orlando, Florida 32816 (United States); Kramer-Marek, Gabriela [The Institute of Cancer Research, London SW7 3RP (United Kingdom); Luna, Brian [Microfluidic Laboratory Automation, University of California-Irvine, Irvine, California 92697-2715 (United States); Kubler, Andre [Department of Medicine, Imperial College London, London SW7 2AZ (United Kingdom); Dey, Bappaditya; Jain, Sanjay [Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 (United States); Foster, Brent [Department of Biomedical Engineering, University of California-Davis, Davis, California 95817 (United States); Papadakis, Georgios Z. [Radiology and Imaging Sciences, National Institutes of Health (NIH), Bethesda, Maryland 32892 (United States); Camp, Jeremy V. [Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky 40202 (United States); Jonsson, Colleen B. [National Institute for Mathematical and Biological Synthesis, University of Tennessee, Knoxville, Tennessee 37996 (United States); Bishai, William R. [Howard Hughes Medical Institute, Chevy Chase, Maryland 20815 and Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 (United States); Udupa, Jayaram K. [Medical Image Processing Group, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States)

    2015-07-15

    Purpose: To develop an automated pulmonary image analysis framework for infectious lung diseases in small animal models. Methods: The authors describe a novel pathological lung and airway segmentation method for small animals. The proposed framework includes identification of abnormal imaging patterns pertaining to infectious lung diseases. First, the authors’ system estimates an expected lung volume by utilizing a regression function between total lung capacity and approximated rib cage volume. A significant difference between the expected lung volume and the initial lung segmentation indicates the presence of severe pathology, and invokes a machine learning based abnormal imaging pattern detection system next. The final stage of the proposed framework is the automatic extraction of airway tree for which new affinity relationships within the fuzzy connectedness image segmentation framework are proposed by combining Hessian and gray-scale morphological reconstruction filters. Results: 133 CT scans were collected from four different studies encompassing a wide spectrum of pulmonary abnormalities pertaining to two commonly used small animal models (ferret and rabbit). Sensitivity and specificity were greater than 90% for pathological lung segmentation (average dice similarity coefficient > 0.9). While qualitative visual assessments of airway tree extraction were performed by the participating expert radiologists, for quantitative evaluation the authors validated the proposed airway extraction method by using publicly available EXACT’09 data set. Conclusions: The authors developed a comprehensive computer-aided pulmonary image analysis framework for preclinical research applications. The proposed framework consists of automatic pathological lung segmentation and accurate airway tree extraction. The framework has high sensitivity and specificity; therefore, it can contribute advances in preclinical research in pulmonary diseases.

  2. Computer-Aided Construction of Chemical Kinetic Models

    Energy Technology Data Exchange (ETDEWEB)

    Green, William H. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

    2014-12-31

    The combustion chemistry of even simple fuels can be extremely complex, involving hundreds or thousands of kinetically significant species. The most reasonable way to deal with this complexity is to use a computer not only to numerically solve the kinetic model, but also to construct the kinetic model in the first place. Because these large models contain so many numerical parameters (e.g. rate coefficients, thermochemistry) one never has sufficient data to uniquely determine them all experimentally. Instead one must work in “predictive” mode, using theoretical rather than experimental values for many of the numbers in the model, and as appropriate refining the most sensitive numbers through experiments. Predictive chemical kinetics is exactly what is needed for computer-aided design of combustion systems based on proposed alternative fuels, particularly for early assessment of the value and viability of proposed new fuels before those fuels are commercially available. This project was aimed at making accurate predictive chemical kinetics practical; this is a challenging goal which requires a range of science advances. The project spanned a wide range from quantum chemical calculations on individual molecules and elementary-step reactions, through the development of improved rate/thermo calculation procedures, the creation of algorithms and software for constructing and solving kinetic simulations, the invention of methods for model-reduction while maintaining error control, and finally comparisons with experiment. Many of the parameters in the models were derived from quantum chemistry calculations, and the models were compared with experimental data measured in our lab or in collaboration with others.

  3. Development of the computer-aided process planning (CAPP system for polymer injection molds manufacturing

    Directory of Open Access Journals (Sweden)

    J. Tepić

    2011-10-01

    Full Text Available Beginning of production and selling of polymer products largely depends on mold manufacturing. The costs of mold manufacturing have significant share in the final price of a product. The best way to improve and rationalize polymer injection molds production process is by doing mold design automation and manufacturing process planning automation. This paper reviews development of a dedicated process planning system for manufacturing of the mold for injection molding, which integrates computer-aided design (CAD, computer-aided process planning (CAPP and computer-aided manufacturing (CAM technologies.

  4. Knowledge-Based, Central Nervous System (CNS) Lead Selection and Lead Optimization for CNS Drug Discovery.

    Science.gov (United States)

    Ghose, Arup K; Herbertz, Torsten; Hudkins, Robert L; Dorsey, Bruce D; Mallamo, John P

    2012-01-18

    The central nervous system (CNS) is the major area that is affected by aging. Alzheimer's disease (AD), Parkinson's disease (PD), brain cancer, and stroke are the CNS diseases that will cost trillions of dollars for their treatment. Achievement of appropriate blood-brain barrier (BBB) penetration is often considered a significant hurdle in the CNS drug discovery process. On the other hand, BBB penetration may be a liability for many of the non-CNS drug targets, and a clear understanding of the physicochemical and structural differences between CNS and non-CNS drugs may assist both research areas. Because of the numerous and challenging issues in CNS drug discovery and the low success rates, pharmaceutical companies are beginning to deprioritize their drug discovery efforts in the CNS arena. Prompted by these challenges and to aid in the design of high-quality, efficacious CNS compounds, we analyzed the physicochemical property and the chemical structural profiles of 317 CNS and 626 non-CNS oral drugs. The conclusions derived provide an ideal property profile for lead selection and the property modification strategy during the lead optimization process. A list of substructural units that may be useful for CNS drug design was also provided here. A classification tree was also developed to differentiate between CNS drugs and non-CNS oral drugs. The combined analysis provided the following guidelines for designing high-quality CNS drugs: (i) topological molecular polar surface area of <76 Å(2) (25-60 Å(2)), (ii) at least one (one or two, including one aliphatic amine) nitrogen, (iii) fewer than seven (two to four) linear chains outside of rings, (iv) fewer than three (zero or one) polar hydrogen atoms, (v) volume of 740-970 Å(3), (vi) solvent accessible surface area of 460-580 Å(2), and (vii) positive QikProp parameter CNS. The ranges within parentheses may be used during lead optimization. One violation to this proposed profile may be acceptable. The

  5. Lead Generation and Optimization Based on Protein-Ligand Complementarity

    Directory of Open Access Journals (Sweden)

    Koji Ogata

    2010-06-01

    Full Text Available This work proposes a computational procedure for structure-based lead generation and optimization, which relies on the complementarity of the protein-ligand interactions. This procedure takes as input the known structure of a protein-ligand complex. Retaining the positions of the ligand heavy atoms in the protein binding site it designs structurally similar compounds considering all possible combinations of atomic species (N, C, O, CH3, NH,etc. Compounds are ranked based on a score which incorporates energetic contributions evaluated using molecular mechanics force fields. This procedure was used to design new inhibitor molecules for three serine/threonine protein kinases (p38 MAP kinase, p42 MAP kinase (ERK2, and c-Jun N-terminal kinase 3 (JNK3. For each enzyme, the calculations produce a set of potential inhibitors whose scores are in agreement with IC50 data and Ki values. Furthermore, the native ligands for each protein target, scored within the five top-ranking compounds predicted by our method, one of the top-ranking compounds predicted to inhibit JNK3 was synthesized and his inhibitory activity confirmed against ATP hydrolysis. Our computational procedure is therefore deemed to be a useful tool for generating chemically diverse molecules active against known target proteins.

  6. Computer aided decision support system for cervical cancer classification

    Science.gov (United States)

    Rahmadwati, Rahmadwati; Naghdy, Golshah; Ros, Montserrat; Todd, Catherine

    2012-10-01

    Conventional analysis of a cervical histology image, such a pap smear or a biopsy sample, is performed by an expert pathologist manually. This involves inspecting the sample for cellular level abnormalities and determining the spread of the abnormalities. Cancer is graded based on the spread of the abnormal cells. This is a tedious, subjective and time-consuming process with considerable variations in diagnosis between the experts. This paper presents a computer aided decision support system (CADSS) tool to help the pathologists in their examination of the cervical cancer biopsies. The main aim of the proposed CADSS system is to identify abnormalities and quantify cancer grading in a systematic and repeatable manner. The paper proposes three different methods which presents and compares the results using 475 images of cervical biopsies which include normal, three stages of pre cancer, and malignant cases. This paper will explore various components of an effective CADSS; image acquisition, pre-processing, segmentation, feature extraction, classification, grading and disease identification. Cervical histological images are captured using a digital microscope. The images are captured in sufficient resolution to retain enough information for effective classification. Histology images of cervical biopsies consist of three major sections; background, stroma and squamous epithelium. Most diagnostic information are contained within the epithelium region. This paper will present two levels of segmentations; global (macro) and local (micro). At the global level the squamous epithelium is separated from the background and stroma. At the local or cellular level, the nuclei and cytoplasm are segmented for further analysis. Image features that influence the pathologists' decision during the analysis and classification of a cervical biopsy are the nuclei's shape and spread; the ratio of the areas of nuclei and cytoplasm as well as the texture and spread of the abnormalities

  7. Improved mammographic interpretation of masses using computer-aided diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Leichter, I. [Dept. of Electro-Optics, Jerusalem College of Technology (Israel); Fields, S.; Novak, B. [Dept. of Radiology, Hadassah University Hospital, Mt. Scopus Jerusalem (Israel); Nirel, R. [Dept. of Statistics, Hebrew University of Jerusalem, Mt. Scopus, Jerusalem (Israel); Bamberger, P. [Dept. of Electronics, Jerusalem College of Technology, Jerusalem (Israel); Lederman, R. [Department of Radiology, Hadassah University Hospital, Ein Kerem, Jerusalem (Israel); Buchbinder, S. [Department of Radiology, Montefiore Medical Center, University Hospital for the Albert Einstein College of Medicine, Bronx, New York (United States)

    2000-02-01

    The aim of this study was to evaluate the effectiveness of computerized image enhancement, to investigate criteria for discriminating benign from malignant mammographic findings by computer-aided diagnosis (CAD), and to test the role of quantitative analysis in improving the accuracy of interpretation of mass lesions. Forty sequential mammographically detected mass lesions referred for biopsy were digitized at high resolution for computerized evaluation. A prototype CAD system which included image enhancement algorithms was used for a better visualization of the lesions. Quantitative features which characterize the spiculation were automatically extracted by the CAD system for a user-defined region of interest (ROI). Reference ranges for malignant and benign cases were acquired from data generated by 214 known retrospective cases. The extracted parameters together with the reference ranges were presented to the radiologist for the analysis of 40 prospective cases. A pattern recognition scheme based on discriminant analysis was trained on the 214 retrospective cases, and applied to the prospective cases. Accuracy of interpretation with and without the CAD system, as well as the performance of the pattern recognition scheme, were analyzed using receiver operating characteristics (ROC) curves. A significant difference (p < 0.005) was found between features extracted by the CAD system for benign and malignant cases. Specificity of the CAD-assisted diagnosis improved significantly (p < 0.02) from 14 % for the conventional assessment to 50 %, and the positive predictive value increased from 0.47 to 0.62 (p < 0.04). The area under the ROC curve (A{sub z}) increased significantly (p < 0.001) from 0.66 for the conventional assessment to 0.81 for the CAD-assisted analysis. The A{sub z} for the results of the pattern recognition scheme was higher (0.95). The results indicate that there is an improved accuracy of diagnosis with the use of the mammographic CAD system above that

  8. Computer Aided Design of Polygalacturonase II from Aspergillus niger

    Directory of Open Access Journals (Sweden)

    Ibrahim Ali Noorbatcha

    2011-12-01

    Full Text Available Pectin is a complex polysaccharide found in the cell walls of plants and consisting mainly of esterified D-galacturonic acid resides in α-(1-4 chain. In production of fruit juice, pectin contributes to fruit juice viscosity, thereby reducing the juice production and increasing the filtration time. Polygalacturonase improves the juice production process by rapid degradation of pectin. In this project we have designed a novel polygalacturonase enzyme using computer aided design approaches. The three dimension structure of polygalacturonase is first modeled on the basis of the known crystal structure. The active site in this enzyme is identified by manual and automated docking methods. Lamarckian genetic algorithm is used for automated docking and the active site is validated by comparing with existing experimental data. This is followed by in silico mutations of the enzymes and the automated docking process is repeated using the mutant enzymes. The strength of the binding of the ligands inside the active site is evaluated by computing the binding score using Potential Mean Force (PMF method. The in silico mutations R256Q and K258N are found to decrease the binding strength of the ligand at the active site, indicating lowering of enzyme activity, which is consistent with the experimental results. Hence in silico mutations can be used to design new polygalacturonase enzymes with improved enzyme activity.ABSTRAK: Pektin adalah polisakarida kompleks yang terdapat di dalam dinding sel tumbuhan dan sebahagian besarnya terdiri daripada asid D-galakturonik terester yang ditemui di dalam rantaian α-(1-4. Dalam penghasilan jus buah-buahan, pektin menyumbang dalam kepekatan jus buah-buahan, di mana ia mengurangkan penghasilan jus dan menambahkan masa penapisan. Poligalakturonase meningkatkan proses penghasilan jus dengan pemecahan pektin dengan cepat. Dalam projek ini, kami telah merangka satu enzim poligalakturonase baru dengan menggunakan pendekatan reka

  9. Predictable Restorative Work Flow for Computer-Aided Design/Computer-Aided Manufacture-Fabricated Ceramic Veneers Utilizing a Virtual Smile Design Principle.

    Science.gov (United States)

    Lin, W S; Zandinejad, A; Metz, M J; Harris, B T; Morton, D

    2015-01-01

    The purpose of this case report was to present the use of a contemporary digital photograph-assisted virtual smile design principle, an intraoral digital impression, and computer-aided design/computer-aided manufacture-fabricated lithium disilicate ceramic veneers to treat a patient with esthetic needs in the maxillary anterior region. By using the proposed digital restorative work flow, this case report demonstrated an effective communication pathway between the patient, clinician, and dental laboratory technician. Effective communication can help to achieve a more predictable and satisfactory esthetic outcome.

  10. SAR and Computer-Aided Drug Design Approaches in the Discovery of Peroxisome Proliferator-Activated Receptor γ Activators: A Perspective

    Directory of Open Access Journals (Sweden)

    Vaibhav A. Dixit

    2013-01-01

    Full Text Available Activators of PPARγ, Troglitazone (TGZ, Rosiglitazone (RGZ, and Pioglitazone (PGZ were introduced for treatment of Type 2 diabetes, but TGZ and RGZ have been withdrawn from the market along with other promising leads due cardiovascular side effects and hepatotoxicity. However, the continuously improving understanding of the structure/function of PPARγ and its interactions with potential ligands maintain the importance of PPARγ as an antidiabetic target. Extensive structure activity relationship (SAR studies have thus been performed on a variety of structural scaffolds by various research groups. Computer-aided drug discovery (CADD approaches have also played a vital role in the search and optimization of potential lead compounds. This paper focuses on these approaches adopted for the discovery of PPARγ ligands for the treatment of Type 2 diabetes. Key concepts employed during the discovery phase, classification based on agonistic character, applications of various QSAR, pharmacophore mapping, virtual screening, molecular docking, and molecular dynamics studies are highlighted. Molecular level analysis of the dynamic nature of ligand-receptor interaction is presented for the future design of ligands with better potency and safety profiles. Recently identified mechanism of inhibition of phosphorylation of PPARγ at SER273 by ligands is reviewed as a new strategy to identify novel drug candidates.

  11. Computer aided design of microcircuits. Citations from the NTIS data base

    Science.gov (United States)

    Reed, W. E.

    1980-09-01

    Government sponsored research covering the computer aided design, modeling, layout, and packaging of integrated and other microelectronic circuits are cited. Computer programs and the use of computer graphics are included.

  12. Computer aided taxonomy (CAT): Approach for understanding systematics of marine biota

    Digital Repository Service at National Institute of Oceanography (India)

    Chavan, V.S.; Kavlekar, D.P.; Chandramohan, D.

    Computer aided taconomy (CAT) is gaining importance day by day. In order to familiarise the taxonomy and its continuing usage an attempt has made to develop a module for knowing the systematics of organisms and to generate automatic numerical code...

  13. Sensitivity analysis of Computer-aided molecular design problem for the development of novel working fluids for power cycles

    DEFF Research Database (Denmark)

    Frutiger, Jerome; Abildskov, Jens; Sin, Gürkan

    allows the ranking ofsignificance of properties and also the identification of a set of properties which are relevant for the design of a workingfluids.In this study the CAMD problem for the development of novel working fluids for organic Rankine cycles (ORC) isformulated as a mathematical optimization...... technical tool to convert this waste heat into usable energy. So far the low-temperature heat cannot be utilized efficiently for electricity generation.In order to optimize the heat transfer process and the power generation, the influence of the working fluid, the cycledesigns and the operating conditions...... is vital. Multi-criteria database search and Computer Aided Molecular Design(CAMD) can be applied to generate, test and evaluate promising pure component/mixture candidate as process fluids to help optimize cycle design and performance. The problem formulation for the development of novel working fluids...

  14. Progress of the Computer-Aided Engineering of Electric Drive Vehicle Batteries (CAEBAT) (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Pesaran, A. A.; Han, T.; Hartridge, S.; Shaffer, C.; Kim, G. H.; Pannala, S.

    2013-06-01

    This presentation, Progress of Computer-Aided Engineering of Electric Drive Vehicle Batteries (CAEBAT) is about simulation and computer-aided engineering (CAE) tools that are widely used to speed up the research and development cycle and reduce the number of build-and-break steps, particularly in the automotive industry. Realizing this, DOE?s Vehicle Technologies Program initiated the CAEBAT project in April 2010 to develop a suite of software tools for designing batteries.

  15. Computer-Aided Transformation of PDE Models: Languages, Representations, and a Calculus of Operations

    Science.gov (United States)

    2016-01-05

    Computer-aided transformation of PDE models: languages, representations, and a calculus of operations A domain-specific embedded language called...languages, representations, and a calculus of operations Report Title A domain-specific embedded language called ibvp was developed to model initial...Computer-aided transformation of PDE models: languages, representations, and a calculus of operations 1 Vision and background Physical and engineered systems

  16. Advanced Methods for the Computer-Aided Diagnosis of Lesions in Digital Mammograms

    Science.gov (United States)

    2000-07-01

    classification of mammographic mass lesions. Radiology 213: 200, 1999. " Nishikawa R, Giger ML, Yarusso L, Kupinski M, Baehr A, Venta L,: Computer-aided...detection of mass lesions in digital mammography using radial gradient index filtering. Radiology 213: 229, 1999. " Maloney M, Huo Z, Giger ML, Venta L...Nishikawa R, Huo Z, Jiang Y, Venta L, Doi K: Computer-aided diagnosis (CAD) in breast imaging. Radiology 213: 507, 1999. -Final Report DAMD 17-96-1-6058 19

  17. Computer-Aided Prototyping Systems (CAPS) within the software acquisition process: a case study

    OpenAIRE

    Ellis, Mary Kay

    1993-01-01

    Approved for public release; distribution is unlimited This thesis provides a case study which examines the benefits derived from the practice of computer-aided prototyping within the software acquisition process. An experimental prototyping systems currently in research is the Computer Aided Prototyping System (CAPS) managed under the Computer Science department of the Naval Postgraduate School, Monterey, California. This thesis determines the qualitative value which may be realized by ...

  18. Computer-aided detection of early interstitial lung diseases using low-dose CT images

    Science.gov (United States)

    Park, Sang Cheol; Tan, Jun; Wang, Xingwei; Lederman, Dror; Leader, Joseph K.; Kim, Soo Hyung; Zheng, Bin

    2011-02-01

    This study aims to develop a new computer-aided detection (CAD) scheme to detect early interstitial lung disease (ILD) using low-dose computed tomography (CT) examinations. The CAD scheme classifies each pixel depicted on the segmented lung areas into positive or negative groups for ILD using a mesh-grid-based region growth method and a multi-feature-based artificial neural network (ANN). A genetic algorithm was applied to select optimal image features and the ANN structure. In testing each CT examination, only pixels selected by the mesh-grid region growth method were analyzed and classified by the ANN to improve computational efficiency. All unselected pixels were classified as negative for ILD. After classifying all pixels into the positive and negative groups, CAD computed a detection score based on the ratio of the number of positive pixels to all pixels in the segmented lung areas, which indicates the likelihood of the test case being positive for ILD. When applying to an independent testing dataset of 15 positive and 15 negative cases, the CAD scheme yielded the area under receiver operating characteristic curve (AUC = 0.884 ± 0.064) and 80.0% sensitivity at 85.7% specificity. The results demonstrated the feasibility of applying the CAD scheme to automatically detect early ILD using low-dose CT examinations.

  19. Initial development of a computer-aided diagnosis tool for solitary pulmonary nodules

    Science.gov (United States)

    Catarious, David M., Jr.; Baydush, Alan H.; Floyd, Carey E., Jr.

    2001-07-01

    This paper describes the development of a computer-aided diagnosis (CAD) tool for solitary pulmonary nodules. This CAD tool is built upon physically meaningful features that were selected because of their relevance to shape and texture. These features included a modified version of the Hotelling statistic (HS), a channelized HS, three measures of fractal properties, two measures of spicularity, and three manually measured shape features. These features were measured from a difficult database consisting of 237 regions of interest (ROIs) extracted from digitized chest radiographs. The center of each 256x256 pixel ROI contained a suspicious lesion which was sent to follow-up by a radiologist and whose nature was later clinically determined. Linear discriminant analysis (LDA) was used to search the feature space via sequential forward search using percentage correct as the performance metric. An optimized feature subset, selected for the highest accuracy, was then fed into a three layer artificial neural network (ANN). The ANN's performance was assessed by receiver operating characteristic (ROC) analysis. A leave-one-out testing/training methodology was employed for the ROC analysis. The performance of this system is competitive with that of three radiologists on the same database.

  20. Computer-Aided Design of Some Advanced Steels and Cemented Carbides

    Institute of Scientific and Technical Information of China (English)

    LI Lin; ZHANG Mei; HE Yan-lin; De Cooman Bruno; Wollants Patrick

    2005-01-01

    Thermodynamic and kinetic study on TRIP (transformation induced plasticity) steels, cemented carbides and mold steel for plastics were carried out in order to design modern advanced materials. With the sublattice model, equilibrium compositions of ferrite and austenite phases in TRIP steels, as well as volume fraction of austenite at inter-critical temperatures for different time were calculated. Concentration profiles of carbon, manganese, aluminum and silicon in the steels were also estimated in the lattice fixed frame of reference. The effect of Si and Mn on TRIP was discussed according to thermodynamic and kinetic analyses. In order to understand and produce the graded nanophase structure of cemented carbides, miscellaneous phases in the M-Co-C (M= Ti, Ta, Nb) systems and Co-V-C system were modeled. Solution parameters and thermodynamic properties were listed in detail. The improvement of machining behavior of prehardened mould steel for plastics was obtained by computer-aided composition design. The results showed that the matrix composition of large-section prehardened mould steel for plastic markedly influences the precipitation of non-metallic inclusion and the composition control by the aid of Thermo-Calc software package minimizes the amount of detrimental oxide inclusion. In addition, the modification of calcium was optimized in composition design.

  1. Learning-based image preprocessing for robust computer-aided detection

    Science.gov (United States)

    Raghupathi, Laks; Devarakota, Pandu R.; Wolf, Matthias

    2013-03-01

    Recent studies have shown that low dose computed tomography (LDCT) can be an effective screening tool to reduce lung cancer mortality. Computer-aided detection (CAD) would be a beneficial second reader for radiologists in such cases. Studies demonstrate that while iterative reconstructions (IR) improve LDCT diagnostic quality, it however degrades CAD performance significantly (increased false positives) when applied directly. For improving CAD performance, solutions such as retraining with newer data or applying a standard preprocessing technique may not be suffice due to high prevalence of CT scanners and non-uniform acquisition protocols. Here, we present a learning-based framework that can adaptively transform a wide variety of input data to boost an existing CAD performance. This not only enhances their robustness but also their applicability in clinical workflows. Our solution consists of applying a suitable pre-processing filter automatically on the given image based on its characteristics. This requires the preparation of ground truth (GT) of choosing an appropriate filter resulting in improved CAD performance. Accordingly, we propose an efficient consolidation process with a novel metric. Using key anatomical landmarks, we then derive consistent feature descriptors for the classification scheme that then uses a priority mechanism to automatically choose an optimal preprocessing filter. We demonstrate CAD prototype∗ performance improvement using hospital-scale datasets acquired from North America, Europe and Asia. Though we demonstrated our results for a lung nodule CAD, this scheme is straightforward to extend to other post-processing tools dedicated to other organs and modalities.

  2. A ROC-based feature selection method for computer-aided detection and diagnosis

    Science.gov (United States)

    Wang, Songyuan; Zhang, Guopeng; Liao, Qimei; Zhang, Junying; Jiao, Chun; Lu, Hongbing

    2014-03-01

    Image-based computer-aided detection and diagnosis (CAD) has been a very active research topic aiming to assist physicians to detect lesions and distinguish them from benign to malignant. However, the datasets fed into a classifier usually suffer from small number of samples, as well as significantly less samples available in one class (have a disease) than the other, resulting in the classifier's suboptimal performance. How to identifying the most characterizing features of the observed data for lesion detection is critical to improve the sensitivity and minimize false positives of a CAD system. In this study, we propose a novel feature selection method mR-FAST that combines the minimal-redundancymaximal relevance (mRMR) framework with a selection metric FAST (feature assessment by sliding thresholds) based on the area under a ROC curve (AUC) generated on optimal simple linear discriminants. With three feature datasets extracted from CAD systems for colon polyps and bladder cancer, we show that the space of candidate features selected by mR-FAST is more characterizing for lesion detection with higher AUC, enabling to find a compact subset of superior features at low cost.

  3. Computer-aided detection of early interstitial lung diseases using low-dose CT images

    Energy Technology Data Exchange (ETDEWEB)

    Park, Sang Cheol; Kim, Soo Hyung [School of Electronics and Computer Engineering, Chonnam National University, Gwangju 500-757 (Korea, Republic of); Tan, Jun; Wang Xingwei; Lederman, Dror; Leader, Joseph K; Zheng Bin, E-mail: zhengb@upmc.edu [Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213 (United States)

    2011-02-21

    This study aims to develop a new computer-aided detection (CAD) scheme to detect early interstitial lung disease (ILD) using low-dose computed tomography (CT) examinations. The CAD scheme classifies each pixel depicted on the segmented lung areas into positive or negative groups for ILD using a mesh-grid-based region growth method and a multi-feature-based artificial neural network (ANN). A genetic algorithm was applied to select optimal image features and the ANN structure. In testing each CT examination, only pixels selected by the mesh-grid region growth method were analyzed and classified by the ANN to improve computational efficiency. All unselected pixels were classified as negative for ILD. After classifying all pixels into the positive and negative groups, CAD computed a detection score based on the ratio of the number of positive pixels to all pixels in the segmented lung areas, which indicates the likelihood of the test case being positive for ILD. When applying to an independent testing dataset of 15 positive and 15 negative cases, the CAD scheme yielded the area under receiver operating characteristic curve (AUC = 0.884 {+-} 0.064) and 80.0% sensitivity at 85.7% specificity. The results demonstrated the feasibility of applying the CAD scheme to automatically detect early ILD using low-dose CT examinations.

  4. Development of simulation tools for numerical investigation and computer-aided design (CAD) of gyrotrons

    Science.gov (United States)

    Damyanova, M.; Sabchevski, S.; Zhelyazkov, I.; Vasileva, E.; Balabanova, E.; Dankov, P.; Malinov, P.

    2016-10-01

    As the most powerful CW sources of coherent radiation in the sub-terahertz to terahertz frequency range the gyrotrons have demonstrated a remarkable potential for numerous novel and prospective applications in the fundamental physical research and the technologies. Among them are powerful gyrotrons for electron cyclotron resonance heating (ECRH) and current drive (ECCD) of magnetically confined plasma in various reactors for controlled thermonuclear fusion (e.g., tokamaks and most notably ITER), high-frequency gyrotrons for sub-terahertz spectroscopy (for example NMR-DNP, XDMR, study of the hyperfine structure of positronium, etc.), gyrotrons for thermal processing and so on. Modelling and simulation are indispensable tools for numerical studies, computer-aided design (CAD) and optimization of such sophisticated vacuum tubes (fast-wave devices) operating on a physical principle known as electron cyclotron resonance maser (ECRM) instability. During the recent years, our research team has been involved in the development of physical models and problem-oriented software packages for numerical analysis and CAD of different gyrotrons in the framework of a broad international collaboration. In this paper we present the current status of our simulation tools (GYROSIM and GYREOSS packages) and illustrate their functionality by results of numerical experiments carried out recently. Finally, we provide an outlook on the envisaged further development of the computer codes and the computational modules belonging to these packages and specialized to different subsystems of the gyrotrons.

  5. Machine Learning in Computer-aided Diagnosis of the Thorax and Colon in CT: A Survey.

    Science.gov (United States)

    Suzuki, Kenji

    2013-04-01

    Computer-aided detection (CADe) and diagnosis (CAD) has been a rapidly growing, active area of research in medical imaging. Machine leaning (ML) plays an essential role in CAD, because objects such as lesions and organs may not be represented accurately by a simple equation; thus, medical pattern recognition essentially require "learning from examples." One of the most popular uses of ML is the classification of objects such as lesion candidates into certain classes (e.g., abnormal or normal, and lesions or non-lesions) based on input features (e.g., contrast and area) obtained from segmented lesion candidates. The task of ML is to determine "optimal" boundaries for separating classes in the multidimensional feature space which is formed by the input features. ML algorithms for classification include linear discriminant analysis (LDA), quadratic discriminant analysis (QDA), multilayer perceptrons, and support vector machines (SVM). Recently, pixel/voxel-based ML (PML) emerged in medical image processing/analysis, which uses pixel/voxel values in images directly, instead of features calculated from segmented lesions, as input information; thus, feature calculation or segmentation is not required. In this paper, ML techniques used in CAD schemes for detection and diagnosis of lung nodules in thoracic CT and for detection of polyps in CT colonography (CTC) are surveyed and reviewed.

  6. Computer-Aided Process Model For Carbon/Phenolic Materials

    Science.gov (United States)

    Letson, Mischell A.; Bunker, Robert C.

    1996-01-01

    Computer program implements thermochemical model of processing of carbon-fiber/phenolic-matrix composite materials into molded parts of various sizes and shapes. Directed toward improving fabrication of rocket-engine-nozzle parts, also used to optimize fabrication of other structural components, and material-property parameters changed to apply to other materials. Reduces costs by reducing amount of laboratory trial and error needed to optimize curing processes and to predict properties of cured parts.

  7. Response Surface Optimization of Lead Azide for Explosive Detonators

    National Research Council Canada - National Science Library

    McCulloh, Ian; Massie, Darrell; Cordaro, Emily

    2006-01-01

    The Armament Research, Development and Engineering Center, Picatinny (ARDEC) has been tasked with developing a new chemical process to produce lead azide, the key explosive ingredient in detonators...

  8. Computer-aided design in power engineering. Application of software tools

    Energy Technology Data Exchange (ETDEWEB)

    Stojkovic, Zlatan

    2012-07-01

    Demonstrates the use software tools in the practice of design in the field of power systems. Presents many applications in the design in the field of power systems. Useful for educative purposes and practical work. This textbooks demonstrates the application of software tools in solving a series of problems from the field of designing power system structures and systems. It contains four chapters: The first chapter leads the reader through all the phases necessary in the procedures of computer aided modeling and simulation. It guides through the complex problems presenting on the basis of eleven original examples. The second chapter presents application of software tools in power system calculations of power systems equipment design. Several design example calculations are carried out using engineering standards like MATLAB, EMTP/ATP, Excel and Access, AutoCAD and Simulink. The third chapters focuses on the graphical documentation using a collection of software tools (AutoCAD, EPLAN, SIMARIS SIVACON, SIMARIS DESIGN) which enable the complete automation of the development of graphical documentation of a power systems. In the fourth chapter, the application of software tools in the project management in power systems is discussed. Here, the emphasis is put on the standard software MS Excel and MS Project.

  9. CT colonography with computer-aided detection: recognizing the causes of false-positive reader results.

    Science.gov (United States)

    Trilisky, Igor; Wroblewski, Kristen; Vannier, Michael W; Horne, John M; Dachman, Abraham H

    2014-01-01

    Computed tomography (CT) colonography is a screening modality used to detect colonic polyps before they progress to colorectal cancer. Computer-aided detection (CAD) is designed to decrease errors of detection by finding and displaying polyp candidates for evaluation by the reader. CT colonography CAD false-positive results are common and have numerous causes. The relative frequency of CAD false-positive results and their effect on reader performance on the basis of a 19-reader, 100-case trial shows that the vast majority of CAD false-positive results were dismissed by readers. Many CAD false-positive results are easily disregarded, including those that result from coarse mucosa, reconstruction, peristalsis, motion, streak artifacts, diverticulum, rectal tubes, and lipomas. CAD false-positive results caused by haustral folds, extracolonic candidates, diminutive lesions (reader false-positive results. Nondismissable CAD soft-tissue polyp candidates larger than 6 mm are another common cause of reader false-positive results that may lead to further evaluation with follow-up CT colonography or optical colonoscopy. Strategies for correctly evaluating CAD polyp candidates are important to avoid pitfalls from common sources of CAD false-positive results. ©RSNA, 2014.

  10. Multiparametric serological testing in autoimmune encephalitis using computer-aided immunofluorescence microscopy (CAIFM).

    Science.gov (United States)

    Fraune, Johanna; Gerlach, Stefan; Rentzsch, Kristin; Teegen, Bianca; Lederer, Sabine; Affeldt, Kai; Fechner, Kai; Danckwardt, Maick; Voigt, Jörn; Probst, Christian; Komorowski, Lars; Stöcker, Winfried

    2016-10-01

    Autoantibodies against neuronal cell surface antigens are tightly associated with immunotherapy-responsive autoimmune encephalitis, and a considerable number of corresponding autoantigens has been identified in recent years. Most patients initially present with overlapping symptoms, and a broad range of autoantibodies has to be considered to establish the correct diagnosis and initiate treatment as soon as possible to prevent irreversible and sometimes even life-threatening damage to the brain. Recombinant cell-based immunofluorescence allows to authentically present fragile membrane-associated surface antigens and, in combination with multiparametric analysis in the form of biochip mosaics, has turned out to be highly beneficial for parallel and prompt determination of anti-neuronal autoantibodies and comprehensive differential diagnostics. For the evaluation of recombinant cell-based IIFT, a semi-automated novel function was introduced into an established platform for computer-aided immunofluorescence microscopy. The system facilitates the microscopic analysis of the tests and supports the laboratory personnel in the rapid issuance of diagnostic findings, which is of major importance for autoimmune encephalitis patients since timely initiation of treatment may lead to their full recovery.

  11. Computer-aided diagnosis and lipidomics analysis to detect and treat breast cancer

    Science.gov (United States)

    Meyer-Bäse, Anke; Retter, Felix; Steinbrücker, Frank; Görke, Robert; Burgeth, Bernhard; Schlossbauer, Thomas

    2010-04-01

    Multi-modality diagnosis techniques are more and more replacing traditional medical imaging for breast cancer detection. Newly emerging advances in both intelligent cancer detection systems and lipidomics technologies offer an excellent opportunity to detect tumors and to understand regulation at the molecular level in many diseases such as cancer. In this paper, we present a detailed computer-aided diagnosis (CAD) systems combining motion artefact reduction and automated feature extraction and classification, and a novel data mining approach for visualization of gene therapy leading to apoptosis in U87 MG glioblastoma cells, a secondary tumor of breast cancer. The achieved results show that the CAD system represents a robust and integrative tool for reliable small contrast enhancing lesions. Graph-clustering methods are introduced as powerful correlation networks which enable a simultaneous exploration and visualization of co-regulation in glioblastoma data. These new paradigms are providing unique "fingerprints" by revealing how the intricate interactions at the lipidome level can be employed to induce apoptosis (cell death) and are thus opening a new window to biomedical frontiers.

  12. Computer-aided design of broad band reflection type amplifiers

    DEFF Research Database (Denmark)

    Hammershaimb, Edgar; Jeppesen, Palle; Schjær-Jacobsen, Hans

    1974-01-01

    Microwave negative resistance reflection type amplifiers using stable transferred electron devices (TED's) are optimized by numerical optimization techniques programmed for an interactive graphic datascreen. The small signal impedance of packaged TED's is measured on an automatic network analyzer....... At the same time the impedance of unpackaged devices are obtained by on-line correction for the package parasitics. The microwave circuit chosen is a multiple slug coaxial cavity, that is modelled by sections of lossy transmission lines including step susceptances. The measured small signal impedance...... of the packaged TED's and the cavity model are used in a direct optimization procedure, in which the calculated minimum gain in the prescribed frequency range is progressively maximized by adjusting the lengths, characteristic impedances and positions of the slugs. The computed results are displayed...

  13. An interactive system for computer-aided diagnosis of breast masses.

    Science.gov (United States)

    Wang, Xingwei; Li, Lihua; Liu, Wei; Xu, Weidong; Lederman, Dror; Zheng, Bin

    2012-10-01

    Although mammography is the only clinically accepted imaging modality for screening the general population to detect breast cancer, interpreting mammograms is difficult with lower sensitivity and specificity. To provide radiologists "a visual aid" in interpreting mammograms, we developed and tested an interactive system for computer-aided detection and diagnosis (CAD) of mass-like cancers. Using this system, an observer can view CAD-cued mass regions depicted on one image and then query any suspicious regions (either cued or not cued by CAD). CAD scheme automatically segments the suspicious region or accepts manually defined region and computes a set of image features. Using content-based image retrieval (CBIR) algorithm, CAD searches for a set of reference images depicting "abnormalities" similar to the queried region. Based on image retrieval results and a decision algorithm, a classification score is assigned to the queried region. In this study, a reference database with 1,800 malignant mass regions and 1,800 benign and CAD-generated false-positive regions was used. A modified CBIR algorithm with a new function of stretching the attributes in the multi-dimensional space and decision scheme was optimized using a genetic algorithm. Using a leave-one-out testing method to classify suspicious mass regions, we compared the classification performance using two CBIR algorithms with either equally weighted or optimally stretched attributes. Using the modified CBIR algorithm, the area under receiver operating characteristic curve was significantly increased from 0.865 ± 0.006 to 0.897 ± 0.005 (p interactive CAD system with a large reference database and achieving improved performance.

  14. Lattice Boltzmann Simulation Optimization on Leading Multicore Platforms

    Energy Technology Data Exchange (ETDEWEB)

    Williams, Samuel; Carter, Jonathan; Oliker, Leonid; Shalf, John; Yelick, Katherine

    2008-02-01

    We present an auto-tuning approach to optimize application performance on emerging multicore architectures. The methodology extends the idea of search-based performance optimizations, popular in linear algebra and FFT libraries, to application-specific computational kernels. Our work applies this strategy to a lattice Boltzmann application (LBMHD) that historically has made poor use of scalar microprocessors due to its complex data structures and memory access patterns. We explore one of the broadest sets of multicore architectures in the HPC literature, including the Intel Clovertown, AMD Opteron X2, Sun Niagara2, STI Cell, as well as the single core Intel Itanium2. Rather than hand-tuning LBMHD for each system, we develop a code generator that allows us identify a highly optimized version for each platform, while amortizing the human programming effort. Results show that our auto-tuned LBMHD application achieves up to a 14x improvement compared with the original code. Additionally, we present detailed analysis of each optimization, which reveal surprising hardware bottlenecks and software challenges for future multicore systems and applications.

  15. The importance of hydration thermodynamics in fragment-to-lead optimization.

    Science.gov (United States)

    Ichihara, Osamu; Shimada, Yuzo; Yoshidome, Daisuke

    2014-12-01

    Using a computational approach to assess changes in solvation thermodynamics upon ligand binding, we investigated the effects of water molecules on the binding energetics of over 20 fragment hits and their corresponding optimized lead compounds. Binding activity and X-ray crystallographic data of published fragment-to-lead optimization studies from various therapeutically relevant targets were studied. The analysis reveals a distinct difference between the thermodynamic profile of water molecules displaced by fragment hits and those displaced by the corresponding optimized lead compounds. Specifically, fragment hits tend to displace water molecules with notably unfavorable excess entropies-configurationally constrained water molecules-relative to those displaced by the newly added moieties of the lead compound during the course of fragment-to-lead optimization. Herein we describe the details of this analysis with the goal of providing practical guidelines for exploiting thermodynamic signatures of binding site water molecules in the context of fragment-to-lead optimization.

  16. Computer-aided synthesis and design of plant utility systems

    Energy Technology Data Exchange (ETDEWEB)

    Petroulas, T.; Reklaitis, G.V.

    1984-01-01

    A design synthesis procedure is developed for preliminary design of utility systems. Given known steam sources (waste heat and auxiliary boilers) and sinks (heating, process injection, and driver horsepower needs), the algorithm determines the optimal header pressure levels, the distribution of steam turbines in the network, and the steam flows between all devices so as to maximize the real work recovered from the sources. Any number of pressure levels can be accommodated at only modest increase in computational effort.

  17. Pilot decision making in a computer-aided flight management situation

    Science.gov (United States)

    Chu, Y. Y.; Rouse, W. B.

    1978-01-01

    An experimental representation of a computer-aided multi-task flight management situation has been developed. A computer aiding program was implemented to serve as a back-up decision maker. An experiment was conducted with a balanced design of several subject runs for different workload levels. This was achieved using three levels of subsystem event arrival rates, three levels of control task involvement, and three levels of availability of computer aiding. Experimental results compared quite favorably with those from a computer simulation which employed a queueing model. It was shown that the aiding had enhanced system performance as well as subjective ratings, and that the adaptive aiding policy further reduced subsystem delay.

  18. The application of computer-aided designated titanium mesh in repairing skull defects

    Directory of Open Access Journals (Sweden)

    Lei ZHANG

    2015-01-01

    Full Text Available Objective To explore the clinical value of repairing skull defects with titanium alloy-mesh of computer-aided design.  Methods A retrospective analysis was done on clinical data of 86 cases with skull defects who underwent repairing using titanium mesh with two-dimensional or three-dimensional computer-aided design.  Results All the incisions achieved primary healing other than one case conducting reoperation due to exposed titanium mesh. Two cases got subcutaneous exudate, one obtained painful mastication and one experienced proliferation of scalp scar.  Conclusions With the computer-aided designated titanium mesh, relevant operation can resume the original state to maximum extent, lower surgical risk, decrease post-operational complications and then obtain satisfying clinical effect. DOI: 10.3969/j.issn.1672-6731.2015.01.015

  19. The Research of Computer Aided Farm Machinery Designing Method Based on Ergonomics

    Science.gov (United States)

    Gao, Xiyin; Li, Xinling; Song, Qiang; Zheng, Ying

    Along with agricultural economy development, the farm machinery product type Increases gradually, the ergonomics question is also getting more and more prominent. The widespread application of computer aided machinery design makes it possible that farm machinery design is intuitive, flexible and convenient. At present, because the developed computer aided ergonomics software has not suitable human body database, which is needed in view of farm machinery design in China, the farm machinery design have deviation in ergonomics analysis. This article puts forward that using the open database interface procedure in CATIA to establish human body database which aims at the farm machinery design, and reading the human body data to ergonomics module of CATIA can product practical application virtual body, using human posture analysis and human activity analysis module to analysis the ergonomics in farm machinery, thus computer aided farm machinery designing method based on engineering can be realized.

  20. A Multi-step and Multi-level approach for Computer Aided Molecular Design

    DEFF Research Database (Denmark)

    A general multi-step approach for setting up, solving and solution analysis of computer aided molecular design (CAMD) problems is presented. The approach differs from previous work within the field of CAMD since it also addresses the need for a computer aided problem formulation and result analysis....... The problem formulation step incorporates a knowledge base for the identification and setup of the design criteria. Candidate compounds are identified using a multi-level generate and test CAMD solution algorithm capable of designing molecules having a high level of molecular detail. A post solution step...... using an Integrated Computer Aided System (ICAS) for result analysis and verification is included in the methodology. Keywords: CAMD, separation processes, knowledge base, molecular design, solvent selection, substitution, group contribution, property prediction, ICAS Introduction The use of Computer...

  1. Study on computer-aided alignment method of reflective zoom systems

    Science.gov (United States)

    Zhou, Jide; Chang, Jun; Xie, Guijuan; Zhang, Ke

    2015-08-01

    Computer-aided alignment is an effective method to improve the imaging quality of high-precision, complex, and off-axis optical systems. However, how to determine the misalignment quickly, exactly and constantly is essential to the technology of computer-aided alignment. Owing to the varying optical characteristics of a zoom system, sensitivity matrices are used in the alignment rather than a single matrix. Thus, the processing of sensitivity matrices is important for the computer-aided alignment of the reflective zoom system. So, the total least squares is proposed in order to solve the problems of the numerical instability and the result inaccuracy which result from the solution of the least squares method directly. Finally, the simulant calculation is processed using the numerical analysis model established in the essay. The results demonstrate that the computation method is rational and effective.

  2. Computer-aided modeling framework for efficient model development, analysis and identification

    DEFF Research Database (Denmark)

    Heitzig, Martina; Sin, Gürkan; Sales Cruz, Mauricio;

    2011-01-01

    branches; the first branch deals with single-scale model development while the second branch introduces features for multiscale model development to the methodology. In this paper, the emphasis is on single-scale model development and application part. The modeling framework and the supported stepwise......Model-based computer aided product-process engineering has attained increased importance in a number of industries, including pharmaceuticals, petrochemicals, fine chemicals, polymers, biotechnology, food, energy, and water. This trend is set to continue due to the substantial benefits computer......-aided methods introduce. The key prerequisite of computer-aided product-process engineering is however the availability of models of different types, forms, and application modes. The development of the models required for the systems under investigation tends to be a challenging and time-consuming task...

  3. Computer Aided Assessment of Reliability Using Finite Element Methods

    Science.gov (United States)

    1991-07-01

    ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER McDonnell Aircraft Company MDC B2303 P.O. Box 516 St. Louis MO 63166-0516 9. SPONSORING...Fatiizue Curves for Kovar, Reverse Bendino...................22 I,-i,-u rc 2-2 S-N Fatigue Curve for Electrical Lead Wire (99.9%`ý Copper Cold Drax ,ý

  4. Lead optimization studies of cinnamic amide EP2 antagonists.

    Science.gov (United States)

    Ganesh, Thota; Jiang, Jianxiong; Yang, Myung-Soon; Dingledine, Ray

    2014-05-22

    Prostanoid receptor EP2 can play a proinflammatory role, exacerbating disease pathology in a variety of central nervous system and peripheral diseases. A highly selective EP2 antagonist could be useful as a drug to mitigate the inflammatory consequences of EP2 activation. We recently identified a cinnamic amide class of EP2 antagonists. The lead compound in this class (5d) displays anti-inflammatory and neuroprotective actions. However, this compound exhibited moderate selectivity to EP2 over the DP1 prostanoid receptor (∼10-fold) and low aqueous solubility. We now report compounds that display up to 180-fold selectivity against DP1 and up to 9-fold higher aqueous solubility than our previous lead. The newly developed compounds also display higher selectivity against EP4 and IP receptors and a comparable plasma pharmacokinetics. Thus, these compounds are useful for proof of concept studies in a variety of models where EP2 activation is playing a deleterious role.

  5. Computer-aided diagnosis for diagnostically challenging breast lesions in DCE-MRI based on image registration and integration of morphologic and dynamic characteristics

    Science.gov (United States)

    Retter, Felix; Plant, Claudia; Burgeth, Bernhard; Botella, Guillermo; Schlossbauer, Thomas; Meyer-Bäse, Anke

    2013-12-01

    Diagnostically challenging lesions comprise both foci (small lesions) and non-mass-like enhancing lesions and pose a challenge to current computer-aided diagnosis systems. Motion-based artifacts lead in dynamic contrast-enhanced breast magnetic resonance to diagnostic misinterpretation; therefore, motion compensation represents an important prerequisite to automatic lesion detection and diagnosis. In addition, the extraction of pertinent kinetic and morphologic features as lesion descriptors is an equally important task. In the present paper, we evaluate the performance of a computer-aided diagnosis system consisting of motion correction, lesion segmentation, and feature extraction and classification. We develop a new feature extractor, the radial Krawtchouk moment, which guarantees rotation invariance. Many novel feature extraction techniques are proposed and tested in conjunction with lesion detection. Our simulation results have shown that motion compensation combined with Minkowski functionals and Bayesian classifier can improve lesion detection and classification.

  6. Strategies for improved interpretation of computer-aided detections for CT colonography utilizing distributed human intelligence.

    Science.gov (United States)

    McKenna, Matthew T; Wang, Shijun; Nguyen, Tan B; Burns, Joseph E; Petrick, Nicholas; Summers, Ronald M

    2012-08-01

    Computer-aided detection (CAD) systems have been shown to improve the diagnostic performance of CT colonography (CTC) in the detection of premalignant colorectal polyps. Despite the improvement, the overall system is not optimal. CAD annotations on true lesions are incorrectly dismissed, and false positives are misinterpreted as true polyps. Here, we conduct an observer performance study utilizing distributed human intelligence in the form of anonymous knowledge workers (KWs) to investigate human performance in classifying polyp candidates under different presentation strategies. We evaluated 600 polyp candidates from 50 patients, each case having at least one polyp ≥6 mm, from a large database of CTC studies. Each polyp candidate was labeled independently as a true or false polyp by 20 KWs and an expert radiologist. We asked each labeler to determine whether the candidate was a true polyp after looking at a single 3D-rendered image of the candidate and after watching a video fly-around of the candidate. We found that distributed human intelligence improved significantly when presented with the additional information in the video fly-around. We noted that performance degraded with increasing interpretation time and increasing difficulty, but distributed human intelligence performed better than our CAD classifier for "easy" and "moderate" polyp candidates. Further, we observed numerous parallels between the expert radiologist and the KWs. Both showed similar improvement in classification moving from single-image to video interpretation. Additionally, difficulty estimates obtained from the KWs using an expectation maximization algorithm correlated well with the difficulty rating assigned by the expert radiologist. Our results suggest that distributed human intelligence is a powerful tool that will aid in the development of CAD for CTC. Copyright © 2012. Published by Elsevier B.V.

  7. Implementation of a tolerance model in a computer aided design and inspection system

    Directory of Open Access Journals (Sweden)

    R. Hunter

    2006-04-01

    Full Text Available Purpose: Purpose of this paper is present a detailed framework to integrate the Computer Aided Design (CAD and Inspection (CAI systems through the integration of the Geometric Dimensioning and Tolerancing (GD&T with the inspection process in coordinate measuring machines (CMMs.Design/methodology/approach: The approach used to develop a prototype of a Knowledge Based System (KBS applied to inspection process establishes a new methodology for integrate the geometric dimensioning and tolerancing (GD&T. The integration is achieved through the definition of the knowledge units for functional properties of GD&T, inspection resources and inspection operations in a common knowledge model. The manufacturing and processing applications are the main topics approach of this paper.Findings: The findings are focused in modeling the features and interactions between knowledge units associated to topology, geometry and tolerances with the inspection process activities. The implementation of the product knowledge model is presented in a computer platform that extracts and represents the GD&T information in a CAI system.Research limitations/implications: The implications are focused on the automation of the inspection process in a KBS application. The future research is focused on the use of artificial intelligent technique, such as genetic algorithms and neural networks, to optimize the time to execute the inspection process.Practical implications: The main outcomes and implication of the KBS prototype application are focused on the reduction of the time spend to develop the inspection process. This KBS application provides the needed information to elaborate this process without the human interface.Originality/value: The original value of this paper is the integration of the design and inspection specification in a unique prototype application. The knowledge model has been defined in a common modeling language (UML and can be implemented in different

  8. Automated detection and quantification of residual brain tumor using an interactive computer-aided detection scheme

    Science.gov (United States)

    Gaffney, Kevin P.; Aghaei, Faranak; Battiste, James; Zheng, Bin

    2017-03-01

    Detection of residual brain tumor is important to evaluate efficacy of brain cancer surgery, determine optimal strategy of further radiation therapy if needed, and assess ultimate prognosis of the patients. Brain MR is a commonly used imaging modality for this task. In order to distinguish between residual tumor and surgery induced scar tissues, two sets of MRI scans are conducted pre- and post-gadolinium contrast injection. The residual tumors are only enhanced in the post-contrast injection images. However, subjective reading and quantifying this type of brain MR images faces difficulty in detecting real residual tumor regions and measuring total volume of the residual tumor. In order to help solve this clinical difficulty, we developed and tested a new interactive computer-aided detection scheme, which consists of three consecutive image processing steps namely, 1) segmentation of the intracranial region, 2) image registration and subtraction, 3) tumor segmentation and refinement. The scheme also includes a specially designed and implemented graphical user interface (GUI) platform. When using this scheme, two sets of pre- and post-contrast injection images are first automatically processed to detect and quantify residual tumor volume. Then, a user can visually examine segmentation results and conveniently guide the scheme to correct any detection or segmentation errors if needed. The scheme has been repeatedly tested using five cases. Due to the observed high performance and robustness of the testing results, the scheme is currently ready for conducting clinical studies and helping clinicians investigate the association between this quantitative image marker and outcome of patients.

  9. Computer-aided breast MR image feature analysis for prediction of tumor response to chemotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Aghaei, Faranak; Tan, Maxine; Liu, Hong; Zheng, Bin, E-mail: Bin.Zheng-1@ou.edu [School of Electrical and Computer Engineering, University of Oklahoma, Norman, Oklahoma 73019 (United States); Hollingsworth, Alan B. [Mercy Women’s Center, Mercy Health Center, Oklahoma City, Oklahoma 73120 (United States); Qian, Wei [Department of Electrical and Computer Engineering, University of Texas, El Paso, Texas 79968 (United States)

    2015-11-15

    Purpose: To identify a new clinical marker based on quantitative kinetic image features analysis and assess its feasibility to predict tumor response to neoadjuvant chemotherapy. Methods: The authors assembled a dataset involving breast MR images acquired from 68 cancer patients before undergoing neoadjuvant chemotherapy. Among them, 25 patients had complete response (CR) and 43 had partial and nonresponse (NR) to chemotherapy based on the response evaluation criteria in solid tumors. The authors developed a computer-aided detection scheme to segment breast areas and tumors depicted on the breast MR images and computed a total of 39 kinetic image features from both tumor and background parenchymal enhancement regions. The authors then applied and tested two approaches to classify between CR and NR cases. The first one analyzed each individual feature and applied a simple feature fusion method that combines classification results from multiple features. The second approach tested an attribute selected classifier that integrates an artificial neural network (ANN) with a wrapper subset evaluator, which was optimized using a leave-one-case-out validation method. Results: In the pool of 39 features, 10 yielded relatively higher classification performance with the areas under receiver operating characteristic curves (AUCs) ranging from 0.61 to 0.78 to classify between CR and NR cases. Using a feature fusion method, the maximum AUC = 0.85 ± 0.05. Using the ANN-based classifier, AUC value significantly increased to 0.96 ± 0.03 (p < 0.01). Conclusions: This study demonstrated that quantitative analysis of kinetic image features computed from breast MR images acquired prechemotherapy has potential to generate a useful clinical marker in predicting tumor response to chemotherapy.

  10. Reducing costs with optimized maintenance strategies. Energie AG Oberoesterreich's practical experience with computer-aided maintenance planning and order processing; Kostensenkung durch optimale Instandhaltungsstrategien. Einsatzerfahrungen der Energie AG Oberoesterreich mit EDV-gestuetzter IH-Planung und Auftragsabwicklung

    Energy Technology Data Exchange (ETDEWEB)

    Lechner, K.D.; Raffelsberger, K.; Steininger, W. [Energie AG Oberoesterreich (Austria); Roeben, U. [Siemens Power Generation AG, Erlangen (Germany)

    2004-07-01

    With the increasing competition, application of the optimal maintenance strategy is gaining importance. Apart from optimizing direct maintenance costs, the effects on profit (e.g. due to loss of production), follow-up costs in plant operation as well as safety-related aspects and the environmental impact are important factors. Without state-of-the-art plant management and maintenance software, efficiently meeting the resulting requirements is quite impossible. (orig.)

  11. SWATHGEN Computer-Aided Design System User’s Manual.

    Science.gov (United States)

    1985-02-01

    cross-sections and 8 longitudi- nal curves at equally spaced polar angles about the lower hull centerline. Hidden lines on the lower hull are removed...while hidden lines on the strut and box are shown dashed. The hull may be shown from any viewpoint given by (R, PHI, THETA). PHI is the polar angle in x...cant angle (radians) STO Toe-out angle (radians) SSS Strut separation at leading edge-waterplane BOX DATA 5 BDD Depth BDC Clearance BDF Forward

  12. Composite Perovskites of Cesium Lead Bromide for Optimized Photoluminescence.

    Science.gov (United States)

    Ling, Yichuan; Tan, Lei; Wang, Xi; Zhou, Yan; Xin, Yan; Ma, Biwu; Hanson, Kenneth; Gao, Hanwei

    2017-07-20

    The halide perovskite CsPbBr3 has shown its promise for green light-emitting diodes. The optimal conditions of photoluminescence and the underlying photophysics, however, remain controversial. To address the inconsistency seen in the previous reports and to offer high-quality luminescent materials that can be readily integrated into functional devices with layered architecture, we created thin films of CsPbBr3/Cs4PbBr6 composites based on a dual-source vapor-deposition method. With the capability of tuning the material composition in a broad range, CsPbBr3 is identified as the only light emitter in the composites. Interestingly, the presence of the photoluminescence-inactive Cs4PbBr6 can significantly enhance the light emitting efficiency of the composites. The unique negative thermal quenching observed near the liquid nitrogen temperature indicates that a type of shallow state generated at the CsPbBr3/Cs4PbBr6 interfaces is responsible for the enhancement of photoluminescence.

  13. The interplay of attention economics and computer-aided detection marks in screening mammography

    Science.gov (United States)

    Schwartz, Tayler M.; Sridharan, Radhika; Wei, Wei; Lukyanchenko, Olga; Geiser, William; Whitman, Gary J.; Haygood, Tamara Miner

    2016-03-01

    Introduction: According to attention economists, overabundant information leads to decreased attention for individual pieces of information. Computer-aided detection (CAD) alerts radiologists to findings potentially associated with breast cancer but is notorious for creating an abundance of false-positive marks. We suspected that increased CAD marks do not lengthen mammogram interpretation time, as radiologists will selectively disregard these marks when present in larger numbers. We explore the relevance of attention economics in mammography by examining how the number of CAD marks affects interpretation time. Methods: We performed a retrospective review of bilateral digital screening mammograms obtained between January 1, 2011 and February 28, 2014, using only weekend interpretations to decrease distractions and the likelihood of trainee participation. We stratified data according to reader and used ANOVA to assess the relationship between number of CAD marks and interpretation time. Results: Ten radiologists, with median experience after residency of 12.5 years (range 6 to 24,) interpreted 1849 mammograms. When accounting for number of images, Breast Imaging Reporting and Data System category, and breast density, increasing numbers of CAD marks was correlated with longer interpretation time only for the three radiologists with the fewest years of experience (median 7 years.) Conclusion: For the 7 most experienced readers, increasing CAD marks did not lengthen interpretation time. We surmise that as CAD marks increase, the attention given to individual marks decreases. Experienced radiologists may rapidly dismiss larger numbers of CAD marks as false-positive, having learned that devoting extra attention to such marks does not improve clinical detection.

  14. Computer-aided diagnosis system based on fuzzy logic for breast cancer categorization.

    Science.gov (United States)

    Miranda, Gisele Helena Barboni; Felipe, Joaquim Cezar

    2015-09-01

    Fuzzy logic can help reduce the difficulties faced by computational systems to represent and simulate the reasoning and the style adopted by radiologists in the process of medical image analysis. The study described in this paper consists of a new method that applies fuzzy logic concepts to improve the representation of features related to image description in order to make it semantically more consistent. Specifically, we have developed a computer-aided diagnosis tool for automatic BI-RADS categorization of breast lesions. The user provides parameters such as contour, shape and density and the system gives a suggestion about the BI-RADS classification. Initially, values of malignancy were defined for each image descriptor, according to the BI-RADS standard. When analyzing contour, for example, our method considers the matching of features and linguistic variables. Next, we created the fuzzy inference system. The generation of membership functions was carried out by the Fuzzy Omega algorithm, which is based on the statistical analysis of the dataset. This algorithm maps the distribution of different classes in a set. Images were analyzed by a group of physicians and the resulting evaluations were submitted to the Fuzzy Omega algorithm. The results were compared, achieving an accuracy of 76.67% for nodules and 83.34% for calcifications. The fit of definitions and linguistic rules to numerical models provided by our method can lead to a tighter connection between the specialist and the computer system, yielding more effective and reliable results. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. Utility and effectiveness of computer-aided diagnosis of dental caries.

    Science.gov (United States)

    Tracy, Kyle D; Dykstra, Bradley A; Gakenheimer, David C; Scheetz, James P; Lacina, Stephani; Scarfe, William C; Farman, Allan G

    2011-01-01

    Digital radiography has created a growing opportunity for computer-aided diagnostic (CAD) tools. The Logicon Caries Detector (LCD), with upgraded CAD software based on user feedback, was re-evaluated for its effectiveness via a retrospective clinical study. Using the upgraded LCD software, 12 dentists (evaluators) blindly assessed 17 radiographs taken by another (attending) dentist, who restored 28 proximal surfaces. The attending dentist confirmed the presence of early dentinal caries, as well as identifying 48 surfaces as caries-free or with enamel caries only subject to noninvasive treatment. The radiographs, imported into the software using a digital imaging and communications in medicine (DICOM) reader, were visually assessed under typical operatory lighting conditions, then with the aid of the software's density analysis tool. The effectiveness of the evaluators was gauged by calculating two measures of performance, sensitivity and specificity, for the detection and classification of dentinal caries. Sensitivity among all evaluator dentists was 30% with the initial image; 34% with the brightness and contrast adjusted image; 39% when the image was sharpened; and 69% when the density analysis tool was utilized. Specificity was found to be 97% with the initial image; 95% with the brightness and contrast adjusted image; 93% with the sharpened image; and 94% when the density analysis tool was used. Compared to the unaided eye, the LCD can significantly improve dentists' ability to detect and classify caries. Dentists may be able to find twice as much early dentinal caries requiring restoration (or at least aggressive noninvasive treatment) than previously, while not unnecessarily restoring additional healthy teeth. The LCD enables dentists to obtain more information from dental digital radiography than is possible with the unaided eye, leading to improved patient care.

  16. Computer-Aided psychotherapy for anxiety disorders: A meta-analytic review

    NARCIS (Netherlands)

    Cuijpers, P.; Marks, I.M.; Straten, van A.; Cavanagh, K; Gega, L.; Andersson, G.

    2009-01-01

    Computer-aided psychotherapy (CP) is said to (1) be as effective as face-to-face psychotherapy, while requiring less therapist time, for anxiety disorder sufferers, (2) speed access to care, and (3) save traveling time. CP may be delivered on stand-alone or Internet-linked computers, palmtop compute

  17. CONTRIBUTIONS FOR DEVELOPING OF A COMPUTER AIDED LEARNING ENVIRONMENT OF DESCRIPTIVE GEOMETRY

    Directory of Open Access Journals (Sweden)

    Antonescu Ion

    2009-07-01

    Full Text Available The paper presents the authors’ contributions for developing a computer code for teaching of descriptive geometry using the computer aided learning techniques. The program was implemented using the programming interface and the 3D modeling capabilities of the AutoCAD system.

  18. Integrated Computer Aided Planning and Manufacture of Advanced Technology Jet Engines

    Directory of Open Access Journals (Sweden)

    B. K. Subhas

    1987-10-01

    Full Text Available This paper highlights an attempt at evolving a computer aided manufacturing system on a personal computer. A case study of an advanced technology jet engine component is included to illustrate various outputs from the system. The proposed system could be an alternate solution to sophisticated and expensive CAD/CAM workstations.

  19. Computer Aided Phenomenography: The Role of Leximancer Computer Software in Phenomenographic Investigation

    Science.gov (United States)

    Penn-Edwards, Sorrel

    2010-01-01

    The qualitative research methodology of phenomenography has traditionally required a manual sorting and analysis of interview data. In this paper I explore a potential means of streamlining this procedure by considering a computer aided process not previously reported upon. Two methods of lexicological analysis, manual and automatic, were examined…

  20. Application of computer-aided multi-scale modelling framework - Aerosol case study

    DEFF Research Database (Denmark)

    Heitzig, Martina; Gregson, Christopher; Sin, Gürkan;

    2011-01-01

    A computer-aided modelling tool for efficient multi-scale modelling has been developed and is applied to solve a multi-scale modelling problem related to design and evaluation of fragrance aerosol products. The developed modelling scenario spans three length scales and describes how droplets...

  1. SMART USE OF COMPUTER-AIDED SPERM ANALYSIS (CASA) TO CHARACTERIZE SPERM MOTION

    Science.gov (United States)

    Computer-aided sperm analysis (CASA) has evolved over the past fifteen years to provide an objective, practical means of measuring and characterizing the velocity and parttern of sperm motion. CASA instruments use video frame-grabber boards to capture multiple images of spermato...

  2. Using the Web To Improve Computer-Aided Instruction in Economics.

    Science.gov (United States)

    Daniel, Joseph I.

    1999-01-01

    Believes that the World Wide Web has great potential for delivering interactive computer-aided instruction using programming language like Java and Javascript. Describes a website on object-oriented microeconomics that integrates a textbook, mini-lecture series, graphical calculator, animated drawing program, spreadsheet, and regression package.…

  3. Lecturers' Perspectives on the Use of a Mathematics-Based Computer-Aided Assessment System

    Science.gov (United States)

    Broughton, Stephen J.; Robinson, Carol L.; Hernandez-Martinez, Paul

    2013-01-01

    Computer-aided assessment (CAA) has been used at a university with one of the largest mathematics and engineering undergraduate cohorts in the UK for more than ten years. Lecturers teaching mathematics to first year students were asked about their current use of CAA in a questionnaire and in interviews. This article presents the issues that these…

  4. Persons with Alzheimer's Disease Make Phone Calls Independently Using a Computer-Aided Telephone System

    Science.gov (United States)

    Perilli, Viviana; Lancioni, Giulio E.; Singh, Nirbhay N.; O'Reilly, Mark F.; Sigafoos, Jeff; Cassano, Germana; Cordiano, Noemi; Pinto, Katia; Minervini, Mauro G.; Oliva, Doretta

    2012-01-01

    This study assessed whether four patients with a diagnosis of Alzheimer's disease could make independent phone calls via a computer-aided telephone system. The study was carried out according to a non-concurrent multiple baseline design across participants. All participants started with baseline during which the telephone system was not available,…

  5. Automatic computer-aided detection of prostate cancer based on multiparametric magnetic resonance image analysis.

    NARCIS (Netherlands)

    Vos, P.C.; Barentsz, J.O.; Karssemeijer, N.; Huisman, H.J.

    2012-01-01

    In this paper, a fully automatic computer-aided detection (CAD) method is proposed for the detection of prostate cancer. The CAD method consists of multiple sequential steps in order to detect locations that are suspicious for prostate cancer. In the initial stage, a voxel classification is performe

  6. Virtual Reality versus Computer-Aided Exposure Treatments for Fear of Flying

    Science.gov (United States)

    Tortella-Feliu, Miquel; Botella, Cristina; Llabres, Jordi; Breton-Lopez, Juana Maria; del Amo, Antonio Riera; Banos, Rosa M.; Gelabert, Joan M.

    2011-01-01

    Evidence is growing that two modalities of computer-based exposure therapies--virtual reality and computer-aided psychotherapy--are effective in treating anxiety disorders, including fear of flying. However, they have not yet been directly compared. The aim of this study was to analyze the efficacy of three computer-based exposure treatments for…

  7. Computer-aided detection in breast MRI : a systematic review and meta-analysis

    NARCIS (Netherlands)

    Dorrius, Monique D.; Jansen-van der Weide, Marijke C.; van Ooijen, Peter M. A.; Pijnappel, Ruud M.; Oudkerk, Matthijs

    To evaluate the additional value of computer-aided detection (CAD) in breast MRI by assessing radiologists' accuracy in discriminating benign from malignant breast lesions. A literature search was performed with inclusion of relevant studies using a commercially available CAD system with automatic

  8. Standalone computer-aided detection compared to radiologists' performance for the detection of mammographic masses

    NARCIS (Netherlands)

    Hupse, R.; Samulski, M.; Lobbes, M.; Heeten, A. den; Imhof-Tas, M.W.; Beijerinck, D.; Pijnappel, R.; Hitge-Boetes, C.; Karssemeijer, N.

    2013-01-01

    OBJECTIVES: We developed a computer-aided detection (CAD) system aimed at decision support for detection of malignant masses and architectural distortions in mammograms. The effect of this system on radiologists' performance depends strongly on its standalone performance. The purpose of this study

  9. Gathering Empirical Evidence Concerning Links between Computer Aided Design (CAD) and Creativity

    Science.gov (United States)

    Musta'amal, Aede Hatib; Norman, Eddie; Hodgson, Tony

    2009-01-01

    Discussion is often reported concerning potential links between computer-aided designing and creativity, but there is a lack of systematic enquiry to gather empirical evidence concerning such links. This paper reports an indication of findings from other research studies carried out in contexts beyond general education that have sought evidence…

  10. Computer aided design of prosthetic sockets for below-knee amputees.

    Science.gov (United States)

    Saunders, C G; Foort, J; Bannon, M; Lean, D; Panych, L

    1985-04-01

    A computer-aided sculpting system for use in prosthetics is described. The prosthetist's sculpting tools now consist of a computer, a graphics terminal, a mouse and an on-screen moveable cursor. Accompanied by the system software, these tools allow systematic modification of a primitive socket using techniques analogous to those used by a prosthetist working with rasps and plaster.

  11. Shape sensing for computer aided below-knee prosthetic socket design.

    Science.gov (United States)

    Fernie, G R; Griggs, G; Bartlett, S; Lunau, K

    1985-04-01

    Shape sensing is useful in the computer aided prosthetic fitting process for two purposes. 1. To input characteristic prosthetic shapes that have been developed over the years through the experience of prosthetists. 2. To provide an accurate and rapid measurement of the anatomical shape of the stump. This paper describes two instruments which have been built to meet these objectives.

  12. Technology and Jobs: Computer-Aided Design. Numerical-Control Machine-Tool Operators. Office Automation.

    Science.gov (United States)

    Stanton, Michael; And Others

    1985-01-01

    Three reports on the effects of high technology on the nature of work include (1) Stanton on applications and implications of computer-aided design for engineers, drafters, and architects; (2) Nardone on the outlook and training of numerical-control machine tool operators; and (3) Austin and Drake on the future of clerical occupations in automated…

  13. MULTI-AGENT COMPUTER AIDED ASSEMBLY PROCESS PLANNING SYSTEM FOR SHIP HULL

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    A multi-agent computer aided assembly process planning system (MCAAPP) for ship hull is presented. The system includes system framework, global facilitator, the macro agent structure, agent communication language, agent-oriented programming language, knowledge representation and reasoning strategy. The system can produce the technological file and technological quota, which can satisfy the production needs of factory.

  14. Incorporating Computer-Aided Software in the Undergraduate Chemical Engineering Core Courses

    Science.gov (United States)

    Alnaizy, Raafat; Abdel-Jabbar, Nabil; Ibrahim, Taleb H.; Husseini, Ghaleb A.

    2014-01-01

    Introductions of computer-aided software and simulators are implemented during the sophomore-year of the chemical engineering (ChE) curriculum at the American University of Sharjah (AUS). Our faculty concurs that software integration within the curriculum is beneficial to our students, as evidenced by the positive feedback received from industry…

  15. Effect of Computer-Aided Instruction on Attitude and Achievement of Fifth Grade Math Students

    Science.gov (United States)

    Shoemaker, Traci L.

    2013-01-01

    The purpose of this quasi-experimental non-equivalent control group study was to test theories of constructivism and motivation, along with research-based teaching practices of differentiating instruction and instructing within a child's Zone of Proximal Development, in measuring the effect of computer-aided instruction on fifth grade students'…

  16. Effect of Computer-Aided Perspective Drawings on Spatial Orientation and Perspective Drawing Achievement

    Science.gov (United States)

    Kurtulus, Aytac

    2011-01-01

    The aim of this study is to investigate the effect of computer-aided Perspective Drawings on eighth grade primary school students' achievement in Spatial Orientation and Perspective Drawing. The study made use of pre-test post-test control group experimental design. The study was conducted with thirty 8th grade students attending a primary school…

  17. Computer-Aided College Algebra: Learning Components that Students Find Beneficial

    Science.gov (United States)

    Aichele, Douglas B.; Francisco, Cynthia; Utley, Juliana; Wescoatt, Benjamin

    2011-01-01

    A mixed-method study was conducted during the Fall 2008 semester to better understand the experiences of students participating in computer-aided instruction of College Algebra using the software MyMathLab. The learning environment included a computer learning system for the majority of the instruction, a support system via focus groups (weekly…

  18. The Computer-Aided Analytic Process Model. Operations Handbook for the Analytic Process Model Demonstration Package

    Science.gov (United States)

    1986-01-01

    Research Note 86-06 THE COMPUTER-AIDED ANALYTIC PROCESS MODEL : OPERATIONS HANDBOOK FOR THE ANALYTIC PROCESS MODEL DE ONSTRATION PACKAGE Ronald G...ic Process Model ; Operations Handbook; Tutorial; Apple; Systems Taxonomy Mod--l; Training System; Bradl1ey infantry Fighting * Vehicle; BIFV...8217. . . . . . . .. . . . . . . . . . . . . . . . * - ~ . - - * m- .. . . . . . . item 20. Abstract -continued companion volume-- "The Analytic Process Model for

  19. Computer-aided decision support systems for endoscopy in the gastrointestinal tract: a review.

    Science.gov (United States)

    Liedlgruber, Michael; Uhl, Andreas

    2011-01-01

    Today, medical endoscopy is a widely used procedure to inspect the inner cavities of the human body. The advent of endoscopic imaging techniques-allowing the acquisition of images or videos-created the possibility for the development of the whole new branch of computer-aided decision support systems. Such systems aim at helping physicians to identify possibly malignant abnormalities more accurately. At the beginning of this paper, we give a brief introduction to the history of endoscopy, followed by introducing the main types of endoscopes which emerged so far (flexible endoscope, wireless capsule endoscope, and confocal laser endomicroscope). We then give a brief introduction to computer-aided decision support systems specifically targeted at endoscopy in the gastrointestinal tract. Then we present general facts and figures concerning computer-aided decision support systems and summarize work specifically targeted at computer-aided decision support in the gastrointestinal tract. This summary is followed by a discussion of some common issues concerning the approaches reviewed and suggestions of possible ways to resolve them.

  20. Data Management Standards in Computer-aided Acquisition and Logistic Support (CALS)

    Science.gov (United States)

    Jefferson, David K.

    1990-01-01

    Viewgraphs and discussion on data management standards in computer-aided acquisition and logistic support (CALS) are presented. CALS is intended to reduce cost, increase quality, and improve timeliness of weapon system acquisition and support by greatly improving the flow of technical information. The phase 2 standards, industrial environment, are discussed. The information resource dictionary system (IRDS) is described.

  1. Increasing computer-aided detection specificity by projection features for CT colonography

    OpenAIRE

    Zhu, Hongbin; Liang, Zhengrong; Pickhardt, Perry J.; Barish, Matthew A.; You, Jiangsheng; Fan, Yi; Lu, Hongbing; Posniak, Erica J.; Richards, Robert J.; Cohen, Harris L.

    2010-01-01

    Purpose: A large number of false positives (FPs) generated by computer-aided detection (CAD) schemes is likely to distract radiologists’ attention and decrease their interpretation efficiency. This study aims to develop projection-based features which characterize true and false positives to increase the specificity while maintaining high sensitivity in detecting colonic polyps.

  2. A Computer-Aided Self-Testing System for Biological Psychology.

    Science.gov (United States)

    Leiblum, M. D.; And Others

    1994-01-01

    Describes the production of a computer-aided, self-testing system for university students enrolled in a first-year course in biological psychology. Project aspects described include selection, acquisition and description of software; question banks and test structures; modes of use (computer or printed version); evaluation; and future plans. (11…

  3. SMART USE OF COMPUTER-AIDED SPERM ANALYSIS (CASA) TO CHARACTERIZE SPERM MOTION

    Science.gov (United States)

    Computer-aided sperm analysis (CASA) has evolved over the past fifteen years to provide an objective, practical means of measuring and characterizing the velocity and parttern of sperm motion. CASA instruments use video frame-grabber boards to capture multiple images of spermato...

  4. Experiments Using Cell Phones in Physics Classroom Education: The Computer-Aided "g" Determination

    Science.gov (United States)

    Vogt, Patrik; Kuhn, Jochen; Muller, Sebastian

    2011-01-01

    This paper continues the collection of experiments that describe the use of cell phones as experimental tools in physics classroom education. We describe a computer-aided determination of the free-fall acceleration "g" using the acoustical Doppler effect. The Doppler shift is a function of the speed of the source. Since a free-falling objects…

  5. Comparative evaluation of support vector machine classification for computer aided detection of breast masses in mammography

    NARCIS (Netherlands)

    Lesniak, J.M.; Hupse, R.; Blanc, R.; Karssemeijer, N.; Sz\\'ekely, G.

    2012-01-01

    False positive (FP) marks represent an obstacle for effective use of computer-aided detection (CADe) of breast masses in mammography. Typically, the problem can be approached either by developing more discriminative features or by employing different classifier designs. In this paper, the usage of s

  6. The Effects of Computer-Aided Concept Cartoons and Outdoor Science Activities on Light Pollution

    Science.gov (United States)

    Aydin, Güliz

    2015-01-01

    The purpose of this study is to create an awareness of light pollution on seventh grade students via computer aided concept cartoon applications and outdoor science activities and to help them develop solutions; and to determine student opinions on the practices carried out. The study was carried out at a middle school in Mugla province of Aegean…

  7. Incorporating Computer-Aided Software in the Undergraduate Chemical Engineering Core Courses

    Science.gov (United States)

    Alnaizy, Raafat; Abdel-Jabbar, Nabil; Ibrahim, Taleb H.; Husseini, Ghaleb A.

    2014-01-01

    Introductions of computer-aided software and simulators are implemented during the sophomore-year of the chemical engineering (ChE) curriculum at the American University of Sharjah (AUS). Our faculty concurs that software integration within the curriculum is beneficial to our students, as evidenced by the positive feedback received from industry…

  8. Persons with Alzheimer's Disease Make Phone Calls Independently Using a Computer-Aided Telephone System

    Science.gov (United States)

    Perilli, Viviana; Lancioni, Giulio E.; Singh, Nirbhay N.; O'Reilly, Mark F.; Sigafoos, Jeff; Cassano, Germana; Cordiano, Noemi; Pinto, Katia; Minervini, Mauro G.; Oliva, Doretta

    2012-01-01

    This study assessed whether four patients with a diagnosis of Alzheimer's disease could make independent phone calls via a computer-aided telephone system. The study was carried out according to a non-concurrent multiple baseline design across participants. All participants started with baseline during which the telephone system was not available,…

  9. [Comparison of two computer-aided recording systems: MT 1602 and Compugnath].

    Science.gov (United States)

    Pröbster, L; Benzing, U

    1990-07-01

    Two computer-aided jaw movement recording systems were compared with each other. The results showed that both systems work satisfactorily for use in reconstructive dentistry and TMJ diagnosis. It is, however, emphasized, that there are a number of shortcomings which may have a negative effect on the recordings.

  10. A Multidisciplinary Research Team Approach to Computer-Aided Drafting (CAD) System Selection. Final Report.

    Science.gov (United States)

    Franken, Ken; And Others

    A multidisciplinary research team was assembled to review existing computer-aided drafting (CAD) systems for the purpose of enabling staff in the Design Drafting Department at Linn Technical College (Missouri) to select the best system out of the many CAD systems in existence. During the initial stage of the evaluation project, researchers…

  11. Computer-Aided Air-Traffic Control In The Terminal Area

    Science.gov (United States)

    Erzberger, Heinz

    1995-01-01

    Developmental computer-aided system for automated management and control of arrival traffic at large airport includes three integrated subsystems. One subsystem, called Traffic Management Advisor, another subsystem, called Descent Advisor, and third subsystem, called Final Approach Spacing Tool. Data base that includes current wind measurements and mathematical models of performances of types of aircraft contributes to effective operation of system.

  12. A Computer-Aided Self-Testing System for Biological Psychology.

    Science.gov (United States)

    Leiblum, M. D.; And Others

    1994-01-01

    Describes the production of a computer-aided, self-testing system for university students enrolled in a first-year course in biological psychology. Project aspects described include selection, acquisition and description of software; question banks and test structures; modes of use (computer or printed version); evaluation; and future plans. (11…

  13. Computer-Aided Detection in Breast Magnetic Resonance Imaging: A Review

    NARCIS (Netherlands)

    Dorrius, M. D.; Van Ooijen, P.M.A.

    2008-01-01

    The aim of this study is to give an overview on the accuracy of the discrimination between benign and malignant breast lesions on MRI with and without the use of a computer-aided detection (CAD) system. One investigator selected relevant articles based on title and abstract. Ten articles were select

  14. Possible Computer Vision Systems and Automated or Computer-Aided Edging and Trimming

    Science.gov (United States)

    Philip A. Araman

    1990-01-01

    This paper discusses research which is underway to help our industry reduce costs, increase product volume and value recovery, and market more accurately graded and described products. The research is part of a team effort to help the hardwood sawmill industry automate with computer vision systems, and computer-aided or computer controlled processing. This paper...

  15. Computer-aided detection of small pulmonary nodules in chest radiographs: an observer study.

    NARCIS (Netherlands)

    Boo, D.W. De; Uffmann, M.; Weber, M.; Bipat, S.; Boorsma, E.F.; Scheerder, M.J.; Freling, N.J.; Schaefer-Prokop, C.M.

    2011-01-01

    RATIONALE AND OBJECTIVES: To evaluate the impact of computer-aided detection (CAD, IQQA-Chest; EDDA Technology, Princeton Junction, NJ) used as second reader on the detection of small pulmonary nodules in chest radiography (CXR). MATERIALS AND METHODS: A total of 113 patients (mean age 62 years) wit

  16. Computer Aided Design of Kaplan Turbine Piston with\tSolidWorks

    Directory of Open Access Journals (Sweden)

    Camelia Jianu

    2010-10-01

    Full Text Available The paper presents the steps for 3D computer aided design (CAD of Kaplan turbine piston made in SolidWorks.The present paper is a tutorial for a Kaplan turbine piston 3D geometry, which is dedicaded to the Parts Sketch and Parts Features design and Drawing Geometry and Drawing Annotation.

  17. Computer aided molecular design with combined molecular modeling and group contribution

    DEFF Research Database (Denmark)

    Harper, Peter Mathias; Gani, Rafiqul; Kolar, Petr

    1999-01-01

    Computer-aided molecular design (CAMD) provides a means for determining molecules or mixtures of molecules (CAMMD) having a desirable set of physicochemical properties. The application range of CAMD is restricted due to limitations on the complexity of the generated molecular structures and on th...

  18. Virtual Reality versus Computer-Aided Exposure Treatments for Fear of Flying

    Science.gov (United States)

    Tortella-Feliu, Miquel; Botella, Cristina; Llabres, Jordi; Breton-Lopez, Juana Maria; del Amo, Antonio Riera; Banos, Rosa M.; Gelabert, Joan M.

    2011-01-01

    Evidence is growing that two modalities of computer-based exposure therapies--virtual reality and computer-aided psychotherapy--are effective in treating anxiety disorders, including fear of flying. However, they have not yet been directly compared. The aim of this study was to analyze the efficacy of three computer-based exposure treatments for…

  19. Computer-aided diagnosis system: a Bayesian hybrid classification method.

    Science.gov (United States)

    Calle-Alonso, F; Pérez, C J; Arias-Nicolás, J P; Martín, J

    2013-10-01

    A novel method to classify multi-class biomedical objects is presented. The method is based on a hybrid approach which combines pairwise comparison, Bayesian regression and the k-nearest neighbor technique. It can be applied in a fully automatic way or in a relevance feedback framework. In the latter case, the information obtained from both an expert and the automatic classification is iteratively used to improve the results until a certain accuracy level is achieved, then, the learning process is finished and new classifications can be automatically performed. The method has been applied in two biomedical contexts by following the same cross-validation schemes as in the original studies. The first one refers to cancer diagnosis, leading to an accuracy of 77.35% versus 66.37%, originally obtained. The second one considers the diagnosis of pathologies of the vertebral column. The original method achieves accuracies ranging from 76.5% to 96.7%, and from 82.3% to 97.1% in two different cross-validation schemes. Even with no supervision, the proposed method reaches 96.71% and 97.32% in these two cases. By using a supervised framework the achieved accuracy is 97.74%. Furthermore, all abnormal cases were correctly classified.

  20. Investigation of computer-aided colonic crypt pattern analysis

    Science.gov (United States)

    Qi, Xin; Pan, Yinsheng; Sivak, Michael V., Jr.; Olowe, Kayode; Rollins, Andrew M.

    2007-02-01

    Colorectal cancer is the second leading cause of cancer-related death in the United States. Approximately 50% of these deaths could be prevented by earlier detection through screening. Magnification chromoendoscopy is a technique which utilizes tissue stains applied to the gastrointestinal mucosa and high-magnification endoscopy to better visualize and characterize lesions. Prior studies have shown that shapes of colonic crypts change with disease and show characteristic patterns. Current methods for assessing colonic crypt patterns are somewhat subjective and not standardized. Computerized algorithms could be used to standardize colonic crypt pattern assessment. We have imaged resected colonic mucosa in vitro (N = 70) using methylene blue dye and a surgical microscope to approximately simulate in vivo imaging with magnification chromoendoscopy. We have developed a method of computerized processing to analyze the crypt patterns in the images. The quantitative image analysis consists of three steps. First, the crypts within the region of interest of colonic tissue are semi-automatically segmented using watershed morphological processing. Second, crypt size and shape parameters are extracted from the segmented crypts. Third, each sample is assigned to a category according to the Kudo criteria. The computerized classification is validated by comparison with human classification using the Kudo classification criteria. The computerized colonic crypt pattern analysis algorithm will enable a study of in vivo magnification chromoendoscopy of colonic crypt pattern correlated with risk of colorectal cancer. This study will assess the feasibility of screening and surveillance of the colon using magnification chromoendoscopy.

  1. Computer-aided training sensorimotor cortex functions in humans before the upper limb transplantation using virtual reality and sensory feedback.

    Science.gov (United States)

    Kurzynski, Marek; Jaskolska, Anna; Marusiak, Jaroslaw; Wolczowski, Andrzej; Bierut, Przemyslaw; Szumowski, Lukasz; Witkowski, Jerzy; Kisiel-Sajewicz, Katarzyna

    2017-08-01

    One of the biggest problems of upper limb transplantation is lack of certainty as to whether a patient will be able to control voluntary movements of transplanted hands. Based on findings of the recent research on brain cortex plasticity, a premise can be drawn that mental training supported with visual and sensory feedback can cause structural and functional reorganization of the sensorimotor cortex, which leads to recovery of function associated with the control of movements performed by the upper limbs. In this study, authors - based on the above observations - propose the computer-aided training (CAT) system, which generating visual and sensory stimuli, should enhance the effectiveness of mental training applied to humans before upper limb transplantation. The basis for the concept of computer-aided training system is a virtual hand whose reaching and grasping movements the trained patient can observe on the VR headset screen (visual feedback) and whose contact with virtual objects the patient can feel as a touch (sensory feedback). The computer training system is composed of three main components: (1) the system generating 3D virtual world in which the patient sees the virtual limb from the perspective as if it were his/her own hand; (2) sensory feedback transforming information about the interaction of the virtual hand with the grasped object into mechanical vibration; (3) the therapist's panel for controlling the training course. Results of the case study demonstrate that mental training supported with visual and sensory stimuli generated by the computer system leads to a beneficial change of the brain activity related to motor control of the reaching in the patient with bilateral upper limb congenital transverse deficiency. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Engineering another class of anti-tubercular lead: Hit to lead optimization of an intriguing class of gyrase ATPase inhibitors.

    Science.gov (United States)

    Jeankumar, Variam Ullas; Reshma, Rudraraju Srilakshmi; Vats, Rahul; Janupally, Renuka; Saxena, Shalini; Yogeeswari, Perumal; Sriram, Dharmarajan

    2016-10-21

    A structure based medium throughput virtual screening campaign of BITS-Pilani in house chemical library to identify novel binders of Mycobacterium tuberculosis gyrase ATPase domain led to the discovery of a quinoline scaffold. Further medicinal chemistry explorations on the right hand core of the early hit, engendered a potent lead demonstrating superior efficacy both in the enzyme and whole cell screening assay. The binding affinity shown at the enzyme level was further corroborated by biophysical characterization techniques. Early pharmacokinetic evaluation of the optimized analogue was encouraging and provides interesting potential for further optimization. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  3. A-mode ultrasound-based registration in computer-aided surgery of the skull.

    Science.gov (United States)

    Amstutz, Christoph; Caversaccio, Marco; Kowal, Jens; Bächler, Richard; Nolte, Lutz-Peter; Häusler, Rudolf; Styner, Martin

    2003-12-01

    To evaluate the integration and accuracy of A (amplitude)-mode ultrasound-based surface matching for noninvasive registration of the head into a frameless computer-aided surgery system for otorhinology and skull base surgery. Experimental study and case series. Academic medical center. Twelve patients underwent anterior and paranasal skull base surgery with the routine use of a computer-aided surgery system. A computer-aided surgery system, based on an optoelectronic localizer, was used to track the skull and the surgical tools, including the A-mode ultrasound probe. The A-mode probe was a 10-MHz immersion transducer. An acoustic lens attached to the transducer focused the ultrasonic beam to a depth of 1 to 10 mm. Accuracy tests were performed for the ultrasound setup. Different surface point distributions were evaluated with respect to matching accuracy on a human cadaver skull specimen equipped with fiducial markers. The matching comparison was based on the fiducial registration error. For the clinical evaluation, the laboratory setup was transferred to the operating room. Noninvasive registration of the skull by using A-mode ultrasound in computer-aided surgery (practical and clinical measurements). The accuracy tests on the human skull specimen revealed that the mean +/- SD fiducial registration error was 1.00 +/- 0.19 mm in the best series for A-mode ultrasound surface matchings and was robust with respect to different sets of surface points. The mean +/- SD root mean square error from the 12 A-mode ultrasound matchings in the patient study was 0.49 +/- 0.20 mm. A-mode ultrasound surface matching can be used as a noninvasive and accurate registration procedure in computer-aided surgery of the head.

  4. A systematic framework for computer-aided design of engineering rubber formulations

    Science.gov (United States)

    Ghosh, Prasenjeet

    This thesis considers the design of engineering rubber formulations, whose unique properties of elasticity and resilience enable diverse applications. Engineering rubber formulations are a complex mixture of different materials called curatives that includes elastomers, fillers, crosslinking agents, accelerators, activators, retarders, anti-oxidants and processing aids, where the amount of curatives must be adjusted for each application. The characterization of the final properties of the rubber in application is complex and depends on the chemical interplay between the different curatives in formulation via vulcanization chemistry. The details of the processing conditions and the thermal, deformational, and chemical environment encountered in application also have a pronounced effect on the performance of the rubber. Consequently, for much of the history of rubber as an engineering material, its recipe formulations have been developed largely by trial-and-error, rather than by a fundamental understanding. A computer-aided, systematic and automated framework for the design of such materials is proposed in this thesis. The framework requires the solution to two sub-problems: (a) the forward problem, which involves prediction of the desired properties when the formulation is known and (b) the inverse problem that requires identification of the appropriate formulation, given the desired target properties. As part of the forward model, the chemistry of accelerated sulfur vulcanization is reviewed that permits integration of the knowledge of the past five decades in the literature to answer some old questions, reconcile some of the contradicting mechanisms and present a holistic description of the governing chemistry. Based on this mechanistic chemistry, a fundamental kinetic model is derived using population balance equations. The model quantitatively describes, for the first time, the different aspects of vulcanization chemistry. Subsequently, a novel three

  5. The Computer-Aided Analytic Process Model. Operations Handbook for the APM (Analytic Process Model) Demonstration Package. Appendix

    Science.gov (United States)

    1986-01-01

    The Analytic Process Model for System Design and Measurement: A Computer-Aided Tool for Analyzing Training Systems and Other Human-Machine Systems. A...separate companion volume--The Computer-Aided Analytic Process Model : Operations Handbook for the APM Demonstration Package is also available under

  6. The analysis of the effective lead-in helps optimize the English class

    Institute of Scientific and Technical Information of China (English)

    张蕾

    2014-01-01

    Lead-in, the first part of a class guides students to enter the teaching aspects of learning; it seems to be the simplest part which takes the least time during the whole class. But the effective lead-in helps optimize the English class. Lead-in of English class in junior high school teaching methods are various. This thesis lists several of effective and practical ways and some lead-in problems that need to be taken to avoid.

  7. Custom-Made Computer-Aided-Design/Computer-Aided-Manufacturing Biphasic Calcium-Phosphate Scaffold for Augmentation of an Atrophic Mandibular Anterior Ridge

    Directory of Open Access Journals (Sweden)

    Francesco Guido Mangano

    2015-01-01

    Full Text Available This report documents the clinical, radiographic, and histologic outcome of a custom-made computer-aided-design/computer-aided-manufactured (CAD/CAM scaffold used for the alveolar ridge augmentation of a severely atrophic anterior mandible. Computed tomographic (CT images of an atrophic anterior mandible were acquired and modified into a 3-dimensional (3D reconstruction model; this was transferred to a CAD program, where a custom-made scaffold was designed. CAM software generated a set of tool-paths for the manufacture of the scaffold on a computer-numerical-control milling machine into the exact shape of the 3D design. A custom-made scaffold was milled from a synthetic micromacroporous biphasic calcium phosphate (BCP block. The scaffold closely matched the shape of the defect: this helped to reduce the time for the surgery and contributed to good healing. One year later, newly formed and well-integrated bone was clinically available, and two implants (AnyRidge, MegaGen, Gyeongbuk, South Korea were placed. The histologic samples retrieved from the implant sites revealed compact mature bone undergoing remodelling, marrow spaces, and newly formed trabecular bone surrounded by residual BCP particles. This study demonstrates that custom-made scaffolds can be fabricated by combining CT scans and CAD/CAM techniques. Further studies on a larger sample of patients are needed to confirm these results.

  8. Planning tools for environmental-orientated technology management - computer aided lifecycle analysis; Planungshilfsmittel fuer das oekologieorientierte Technologiemanagement - Computer Aided Lifecycle Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Boehlke, U.H. [Fraunhofer-Institut fuer Produktionstechnologie, Aachen (Germany); Eversheim, W.; Albrecht, T.

    1995-12-31

    The high pressure on prices in the automotive industry as well as the aim to improve the ecological tolerance of the individual motor car traffic requires a considerate employment of natural ressources. In this connection the selection of material is of special improtance. Due to the systematic recording and evaluation of appropriate requirements of ressources, decissions concerning the selection of material and technology can be supported with a product-related and comprehensive balance in kind. The EDV-prototype CALA (Computer Aided Lifecycle Analysis) was developed in order to reduce the effort of a balance in kind to a minimum. CALA supports the user in capturing data and data processing through a dialogue-oriented display mask and through providing of relevant ecological master data. (orig.) [Deutsch] Sowohl der hohe Kostendruck in der Automobilbranche als auch das Ziel die oekologische Vertraeglichkeit des Individualverkehrs zu verbessern, erfordern einen schonenden Einsatz der natuerlichen Ressourcen. Eine besondere Bedeutung kommt dabei der Werkstoffauswahl zu. Mit einer produktbezogenen, ganzheitlichen Sachbilanzierung koennen, durch die systematische Erfassung und Bewertung entsprechender Ressourcenbedarfe und Umweltbelastungen, Entscheidungen bei der Werkstoff- oder Technologieauswahl unterstuetzt werden. Um den Aufwand bei der Durchfuehrung einer Sachbilanzierung zu minimieren, wurde der EDV-Prototyp CALA (Computer Aided Lifecycle Analysis) entwickelt. Der Anwender wird bei CALA durch dialogorientierte Bildschirmmasken und die Bereitstellung oekologisch relevanter Stammdaten bei der Datenerfassung und Auswertung effektiv unterstuetzt. (orig.)

  9. Evaluation of marginal/internal fit of chrome-cobalt crowns: Direct laser metal sintering versus computer-aided design and computer-aided manufacturing.

    Science.gov (United States)

    Gunsoy, S; Ulusoy, M

    2016-01-01

    The purpose of this study was to evaluate the internal and marginal fit of chrome cobalt (Co-Cr) crowns were fabricated with laser sintering, computer-aided design (CAD) and computer-aided manufacturing, and conventional methods. Polyamide master and working models were designed and fabricated. The models were initially designed with a software application for three-dimensional (3D) CAD (Maya, Autodesk Inc.). All models were fabricated models were produced by a 3D printer (EOSINT P380 SLS, EOS). 128 1-unit Co-Cr fixed dental prostheses were fabricated with four different techniques: Conventional lost wax method, milled wax with lost-wax method (MWLW), direct laser metal sintering (DLMS), and milled Co-Cr (MCo-Cr). The cement film thickness of the marginal and internal gaps was measured by an observer using a stereomicroscope after taking digital photos in ×24. Best fit rates according to mean and standard deviations of all measurements was in DLMS both in premolar (65.84) and molar (58.38) models in μm. A significant difference was found DLMS and the rest of fabrication techniques (P 0.05). DMLS was best fitting fabrication techniques for single crown based on the results.The best fit was found in marginal; the larger gap was found in occlusal.All groups were within the clinically acceptable misfit range.

  10. Extended precision data types for the development of the original computer aided engineering applications

    Science.gov (United States)

    Pescaru, A.; Oanta, E.; Axinte, T.; Dascalescu, A.-D.

    2015-11-01

    Computer aided engineering is based on models of the phenomena which are expressed as algorithms. The implementations of the algorithms are usually software applications which are processing a large volume of numerical data, regardless the size of the input data. In this way, the finite element method applications used to have an input data generator which was creating the entire volume of geometrical data, starting from the initial geometrical information and the parameters stored in the input data file. Moreover, there were several data processing stages, such as: renumbering of the nodes meant to minimize the size of the band length of the system of equations to be solved, computation of the equivalent nodal forces, computation of the element stiffness matrix, assemblation of system of equations, solving the system of equations, computation of the secondary variables. The modern software application use pre-processing and post-processing programs to easily handle the information. Beside this example, CAE applications use various stages of complex computation, being very interesting the accuracy of the final results. Along time, the development of CAE applications was a constant concern of the authors and the accuracy of the results was a very important target. The paper presents the various computing techniques which were imagined and implemented in the resulting applications: finite element method programs, finite difference element method programs, applied general numerical methods applications, data generators, graphical applications, experimental data reduction programs. In this context, the use of the extended precision data types was one of the solutions, the limitations being imposed by the size of the memory which may be allocated. To avoid the memory-related problems the data was stored in files. To minimize the execution time, part of the file was accessed using the dynamic memory allocation facilities. One of the most important consequences of the

  11. Best Practices of Computer-Aided Drug Discovery: Lessons Learned from the Development of a Preclinical Candidate for Prostate Cancer with a New Mechanism of Action.

    Science.gov (United States)

    Ban, Fuqiang; Dalal, Kush; Li, Huifang; LeBlanc, Eric; Rennie, Paul S; Cherkasov, Artem

    2017-05-22

    Small-molecule drug design is a complex and iterative decision-making process relying on pre-existing knowledge and driven by experimental data. Low-molecular-weight chemicals represent an attractive therapeutic option, as they are readily accessible to organic synthesis and can easily be characterized.1 Their potency as well as pharmacokinetic and pharmacodynamic properties can be systematically and rationally investigated and ultimately optimized via expert science behind medicinal chemistry and methods of computer-aided drug design (CADD). In recent years, significant advances in molecular modeling techniques have afforded a variety of tools to effectively identify potential binding pockets on prospective targets, to map key interactions between ligands and their binding sites, to construct and assess energetics of the resulting complexes, to predict ADMET properties of candidate compounds, and to systematically analyze experimental and computational data to derive meaningful structure-activity relationships leading to the creation of a drug candidate. This Perspective describes a real case of a drug discovery campaign accomplished in a relatively short time with limited resources. The study integrated an arsenal of available molecular modeling techniques with an array of experimental tools to successfully develop a novel class of potent and selective androgen receptor inhibitors with a novel mode of action. It resulted in the largest academic licensing deal in Canadian history, totaling $142M. This project exemplifies the importance of team science, an integrative approach to drug discovery, and the use of best practices in CADD. We posit that the lessons learned and best practices for executing an effective CADD project can be applied, with similar success, to many drug discovery projects in both academia and industry.

  12. Computer-aided system for hazard zone identification in ship power plants

    Institute of Scientific and Technical Information of China (English)

    PODSIADLO A; TARELKO W

    2005-01-01

    The most dangerous places in ships are their power plants. Particularly, they are very unsafe for operators carrying out various necessary operation and maintenance activities. For this reason, ship machinery should be designed to ensure the maximum safety for its operators. It is a very difficult task. Therefore, it could not be solved by means of conventional design methods, which are used for design of uncomplicated technical equipment. One of the possible ways of solving this problem is to provide appropriate tools, which allow us to take the operator's safety into account during a design process, especially at its early stages. A computer-aided system supporting design of safe ship power plants could be such a tool. This paper deals with developing process of a prototype of the computer-aided system for hazard zone identification in ship power plants.

  13. COMPUTER-AIDED BLOCK ASSEMBLY PROCESS PLANNING IN SHIPBUILD-ING BASED ON RULE-REASONING

    Institute of Scientific and Technical Information of China (English)

    ZHANG Zhiying; LI Zhen; JIANG Zhibin

    2008-01-01

    Computer-aided block assembly process planning based on rule-reasoning are developed in order to improve the assembly efficiency and implement the automated block assembly process planning generation in shipbuilding. First, weighted directed liaison graph (WDLG) is proposed to represent the model of block assembly process according to the characteristics of assembly relation, and edge list (EL) is used to describe assembly sequences. Shapes and assembly attributes of block parts are analyzed to determine the assembly position and matched parts of parts used frequently. Then, a series of assembly rules are generalized, and assembly sequences for block are obtained by means of rule reasoning. Final, a prototype system of computer-aided block assembly process planning is built. The system has been tested on actual block, and the results were found to be quite efficiency. Meanwhile, the fundament for the automation of block assembly process generation and integration with other systems is established.

  14. Computer-aided Nonlinear Control System Design Using Describing Function Models

    CERN Document Server

    Nassirharand, Amir

    2012-01-01

    A systematic computer-aided approach provides a versatile setting for the control engineer to overcome the complications of controller design for highly nonlinear systems. Computer-aided Nonlinear Control System Design provides such an approach based on the use of describing functions. The text deals with a large class of nonlinear systems without restrictions on the system order, the number of inputs and/or outputs or the number, type or arrangement of nonlinear terms. The strongly software-oriented methods detailed facilitate fulfillment of tight performance requirements and help the designer to think in purely nonlinear terms, avoiding the expedient of linearization which can impose substantial and unrealistic model limitations and drive up the cost of the final product. Design procedures are presented in a step-by-step algorithmic format each step being a functional unit with outputs that drive the other steps. This procedure may be easily implemented on a digital computer with example problems from mecha...

  15. Computer-aided analysis and design of the shape rolling process for producing turbine engine airfoils

    Science.gov (United States)

    Lahoti, G. D.; Akgerman, N.; Altan, T.

    1978-01-01

    Mild steel (AISI 1018) was selected as model cold rolling material and Ti-6A1-4V and Inconel 718 were selected as typical hot rolling and cold rolling alloys, respectively. The flow stress and workability of these alloys were characterized and friction factor at the roll/workpiece interface was determined at their respective working conditions by conducting ring tests. Computer-aided mathematical models for predicting metal flow and stresses, and for simulating the shape rolling process were developed. These models utilized the upper bound and the slab methods of analysis, and were capable of predicting the lateral spread, roll separating force, roll torque, and local stresses, strains and strain rates. This computer-aided design system was also capable of simulating the actual rolling process, and thereby designing the roll pass schedule in rolling of an airfoil or a similar shape.

  16. A computer-aided software-tool for sustainable process synthesis-intensification

    DEFF Research Database (Denmark)

    Kumar Tula, Anjan; Babi, Deenesh K.; Bottlaender, Jack

    2017-01-01

    and determine within the design space, the more sustainable processes. In this paper, an integrated computer-aided software-tool that searches the design space for hybrid/intensified more sustainable process options is presented. Embedded within the software architecture are process synthesis...... constraints while also matching the design targets, they are therefore more sustainable than the base case. The application of the software-tool to the production of biodiesel is presented, highlighting the main features of the computer-aided, multi-stage, multi-scale methods that are able to determine more......Currently, the process industry is moving towards the design of innovative, more sustainable processes that show improvements in both economic and environmental factors. The design space of unit operations that can be combined to generate process flowsheet alternatives considering known unit...

  17. Automatic pterygium detection on cornea images to enhance computer-aided cortical cataract grading system.

    Science.gov (United States)

    Gao, Xinting; Wong, Damon Wing Kee; Aryaputera, Aloysius Wishnu; Sun, Ying; Cheng, Ching-Yu; Cheung, Carol; Wong, Tien Yin

    2012-01-01

    In this paper, we present a new method to detect pterygiums using cornea images. Due to the similarity of appearances and spatial locations between pterygiums and cortical cataracts, pterygiums are often falsely detected as cortical cataracts on retroillumination images by a computer-aided grading system. The proposed method can be used to filter out the pterygium which improves the accuracy of cortical cataract grading system. This work has three major contributions. First, we propose a new pupil segmentation method for visible wavelength images. Second, an automatic detection method of pterygiums is proposed. Third, we develop an enhanced compute-aided cortical cataract grading system that excludes pterygiums. The proposed method is tested using clinical data and the experimental results demonstrate that the proposed method can improve the existing automatic cortical cataract grading system.

  18. Computer-aided modeling for efficient and innovative product-process engineering

    DEFF Research Database (Denmark)

    Heitzig, Martina

    Model-based computer aided product-process engineering has attained increased importance in a number of industries, including pharmaceuticals, petrochemicals, fine chemicals, polymers, biotechnology, food, energy and water. This trend is set to continue due to the substantial benefits computer...... in chemical and biochemical engineering have been solved to illustrate the application of the generic modelling methodology, the computeraided modelling framework and the developed software tool.......-aided methods provide. The key prerequisite of computer-aided productprocess engineering is however the availability of models of different types, forms and application modes. The development of the models required for the systems under investigation tends to be a challenging, time-consuming and therefore cost...

  19. Computer Aided Design and Analysis of Separation Processes with Electrolyte Systems

    DEFF Research Database (Denmark)

    Takano, Kiyoteru; Gani, Rafiqul; Kolar, P.

    2000-01-01

    A methodology for computer aided design and analysis of separation processes involving electrolyte systems is presented. The methodology consists of three main parts. The thermodynamic part 'creates' the problem specific property model package, which is a collection of pure component and mixture...... property models. The design and analysis part generates process (flowsheet) alternatives, evaluates/analyses feasibility of separation and provides a visual operation path for the desired separation. The simulation part consists of a simulation/calculation engine that allows the screening and validation...... of process alternatives. For the simulation part, a general multi-purpose, multi-phase separation model has been developed and integrated to an existing computer aided system. Application of the design and analysis methodology is highlighted through two illustrative case studies, (C) 2000 Elsevier Science...

  20. Computer Aided Design and Analysis of Separation Processes with Electrolyte Systems

    DEFF Research Database (Denmark)

    A methodology for computer aided design and analysis of separation processes involving electrolyte systems is presented. The methodology consists of three main parts. The thermodynamic part "creates" the problem specific property model package, which is a collection of pure component and mixture...... property models. The design and analysis part generates process (flowsheet) alternatives, evaluates/analyses feasibility of separation and provides a visual operation path for the desired separation. The simulation part consists of a simulation/calculation engine that allows the screening and validation...... of process alternatives. For the simulation part, a general multi-purpose, multi-phase separation model has been developed and integrated to an existing computer aided system. Application of the design and analysis methodology is highlighted through two illustrative case studies....

  1. Computer aided virtual manufacturing using Creo parametric easy to learn step by step guide

    CERN Document Server

    Kanife, Paul Obiora

    2016-01-01

    Providing a step-by-step guide for the implementation of virtual manufacturing using Creo Parametric software (formerly known as Pro-Engineer), this book creates an engaging and interactive learning experience for manufacturing engineering students. Featuring graphic illustrations of simulation processes and operations, and written in accessible English to promote user-friendliness, the book covers key topics in the field including: the engraving machining process, face milling, profile milling, surface milling, volume rough milling, expert machining, electric discharge machining (EDM), and area turning using the lathe machining process. Maximising reader insights into how to simulate material removal processes, and how to generate cutter location data and G-codes data, this valuable resource equips undergraduate, postgraduate, BTech and HND students in the fields of manufacturing engineering, computer aided design (CAD) and computer aided engineering (CAE) with transferable skills and knowledge. This book is...

  2. Application of computer-aided multi-scale modelling framework – Aerosol case study

    DEFF Research Database (Denmark)

    Heitzig, Martina; Sin, Gürkan; Glarborg, Peter

    Model-based computer aided product-process engineering has attained increased importance in a number of industries, including pharmaceuticals, petrochemicals, fine chemicals, polymers, biotechnology, food, energy and water. This trend is set to continue due to the substantial benefits computer...... development part supports the modeller in model documentation, construction and analysis.Different models for properties, phenomena, unit operations, processes can be developed and analysed here or retrieved from model libraries.The model equations are introduced in a simple text format and are translated......-aided methods provide. The key prerequisite of computer-aided product-process engineering is however the availability of models of different types, forms and application modes. The development of the models required for the systems under investigation tends to be a challenging and time-consuming task involving...

  3. On the convergence of nanotechnology and Big Data analysis for computer-aided diagnosis.

    Science.gov (United States)

    Rodrigues, Jose F; Paulovich, Fernando V; de Oliveira, Maria Cf; de Oliveira, Osvaldo N

    2016-04-01

    An overview is provided of the challenges involved in building computer-aided diagnosis systems capable of precise medical diagnostics based on integration and interpretation of data from different sources and formats. The availability of massive amounts of data and computational methods associated with the Big Data paradigm has brought hope that such systems may soon be available in routine clinical practices, which is not the case today. We focus on visual and machine learning analysis of medical data acquired with varied nanotech-based techniques and on methods for Big Data infrastructure. Because diagnosis is essentially a classification task, we address the machine learning techniques with supervised and unsupervised classification, making a critical assessment of the progress already made in the medical field and the prospects for the near future. We also advocate that successful computer-aided diagnosis requires a merge of methods and concepts from nanotechnology and Big Data analysis.

  4. Computer-Aided Design Method of Warp-Knitted Jacquard Spacer Fabrics

    Directory of Open Access Journals (Sweden)

    Li Xinxin

    2016-06-01

    Full Text Available Based on a further study on knitting and jacquard principles, this paper presents a mathematical design model to make computer-aided design of warp-knitted jacquard spacer fabrics more efficient. The mathematical model with matrix method employs three essential elements of chain notation, threading and Jacquard designing. With this model, the processing to design warp-knitted jacquard spacer fabrics with CAD software is also introduced. In this study, the sports shoes which have separated functional areas according to the feet structure and characteristics of movement are analysed. The results show the different patterns on Jacquard spacer fabrics that are seamlessly stitched with jacquard technics. The computer-aided design method of warp-knitted jacquard spacer fabrics is efficient and simple.

  5. A Computer-Aided FPS-Oriented Approach for Construction Briefing

    Institute of Scientific and Technical Information of China (English)

    Xiaochun Luo; Qiping Shen

    2008-01-01

    Function performance specification (FPS) is one of the value management (VM) techniques de- veloped for the explicit statement of optimum product definition. This technique is widely used in software engineering and manufacturing industry, and proved to be successful to perform product defining tasks. This paper describes an FPS-odented approach for construction briefing, which is critical to the successful deliv- ery of construction projects. Three techniques, i.e., function analysis system technique, shared space, and computer-aided toolkit, are incorporated into the proposed approach. A computer-aided toolkit is developed to facilitate the implementation of FPS in the briefing processes. This approach can facilitate systematic, ef- ficient identification, clarification, and representation of client requirements in trail running. The limitations of the approach and future research work are also discussed at the end of the paper.

  6. Chapter 6 – Computer-Aided Molecular Design and Property Prediction

    DEFF Research Database (Denmark)

    Gani, Rafiqul; Zhang, L.; Kalakul, Sawitree

    2017-01-01

    Today's society needs many chemical-based products for its survival, nutrition, health, transportation, agriculture, and the functioning of processes. Chemical-based products have to be designed/developed in order to meet these needs, while at the same time, they must be innovative and sustainable...... to meet the global challenges of resources, competition, and demand. Design/development of these products mostly follows experiment-based trial and error approaches. With the availability of reliable property prediction models, however, computer-aided techniques have become popular, at least...... for the initial stages of the design/development process. Therefore, computer-aided molecular design and property prediction techniques are two topics that play important roles in chemical product design, analysis, and application. In this chapter, an overview of the concepts, methods, and tools related...

  7. Use of computer aided drafting for analysis and control of posture in manual work.

    Science.gov (United States)

    Ulin, S S; Armstrong, T J; Radwin, R G

    1990-06-01

    Computer aided design (CAD) in conjunction with digitised anthropometric manikins can be used for analysis and control of stressful work postures, one of the most frequently cited occupational risk factors of upper extremity cumulative trauma disorders. This paper describes the use of macros for manipulating manikins and workstation components and for designing the workplace. AutoCAD, a popular computer aided design software package, was used to demonstrate the feasibility of these concepts. Specifically, macros are used for drawing work equipment using parametric designs, manipulating manikins and analysing jobs. In comparing the macros to the use of primitive CAD commands, the macros not only decrease the amount of time needed to create workstation components, but they also make the task easier for the user and decrease the risk of errors. Despite the limitation of anthropometric data and manikins, CAD is an effective method for identifying postural stresses and redesigning the workstation to control the identified stresses.

  8. Computer Aided Design and Analysis of Separation Processes with Electrolyte Systems

    DEFF Research Database (Denmark)

    A methodology for computer aided design and analysis of separation processes involving electrolyte systems is presented. The methodology consists of three main parts. The thermodynamic part "creates" the problem specific property model package, which is a collection of pure component and mixture...... property models. The design and analysis part generates process (flowsheet) alternatives, evaluates/analyses feasibility of separation and provides a visual operation path for the desired separation. The simulation part consists of a simulation/calculation engine that allows the screening and validation...... of process alternatives. For the simulation part, a general multi-purpose, multi-phase separation model has been developed and integrated to an existing computer aided system. Application of the design and analysis methodology is highlighted through two illustrative case studies....

  9. Computer-aided determination of occlusal contact points for dental 3-D CAD.

    Science.gov (United States)

    Maruyama, Tomoaki; Nakamura, Yasuo; Hayashi, Toyohiko; Kato, Kazumasa

    2006-05-01

    Present dental CAD systems enable us to design functional occlusal tooth surfaces which harmonize with the patient's stomatognathic function. In order to avoid occlusal interferences during tooth excursions, currently available systems usually use the patient's functional occlusal impressions for the design of occlusal contact points. Previous interfere-free design, however, has been done on a trial-and-error basis by using visual inspection. To improve this time-consuming procedure, this paper proposes a computer-aided system for assisting in the determination of the occlusal contact points by visualizing the appropriate regions of the opposing surface. The system can designate such regions from data of the opposing occlusal surfaces and their relative movements can be simulated by using a virtual articulator. Experiments for designing the crown of a lower first molar demonstrated that all contact points selected within the designated regions completely satisfied the required contact or separation during tooth excursions, confirming the effectiveness of our computer-aided procedure.

  10. Trends in Computer-Aided Manufacturing in Prosthodontics: A Review of the Available Streams

    Directory of Open Access Journals (Sweden)

    Jaafar Abduo

    2014-01-01

    Full Text Available In prosthodontics, conventional methods of fabrication of oral and facial prostheses have been considered the gold standard for many years. The development of computer-aided manufacturing and the medical application of this industrial technology have provided an alternative way of fabricating oral and facial prostheses. This narrative review aims to evaluate the different streams of computer-aided manufacturing in prosthodontics. To date, there are two streams: the subtractive and the additive approaches. The differences reside in the processing protocols, materials used, and their respective accuracy. In general, there is a tendency for the subtractive method to provide more homogeneous objects with acceptable accuracy that may be more suitable for the production of intraoral prostheses where high occlusal forces are anticipated. Additive manufacturing methods have the ability to produce large workpieces with significant surface variation and competitive accuracy. Such advantages make them ideal for the fabrication of facial prostheses.

  11. Trends in computer-aided manufacturing in prosthodontics: a review of the available streams.

    Science.gov (United States)

    Abduo, Jaafar; Lyons, Karl; Bennamoun, Mohammed

    2014-01-01

    In prosthodontics, conventional methods of fabrication of oral and facial prostheses have been considered the gold standard for many years. The development of computer-aided manufacturing and the medical application of this industrial technology have provided an alternative way of fabricating oral and facial prostheses. This narrative review aims to evaluate the different streams of computer-aided manufacturing in prosthodontics. To date, there are two streams: the subtractive and the additive approaches. The differences reside in the processing protocols, materials used, and their respective accuracy. In general, there is a tendency for the subtractive method to provide more homogeneous objects with acceptable accuracy that may be more suitable for the production of intraoral prostheses where high occlusal forces are anticipated. Additive manufacturing methods have the ability to produce large workpieces with significant surface variation and competitive accuracy. Such advantages make them ideal for the fabrication of facial prostheses.

  12. Computer-aided diagnosis of breast MRI with high accuracy optical flow estimation

    Science.gov (United States)

    Meyer-Baese, Anke; Barbu, Adrian; Lobbes, Marc; Hoffmann, Sebastian; Burgeth, Bernhard; Kleefeld, Andreas; Meyer-Bäse, Uwe

    2015-05-01

    Non-mass enhancing lesions represent a challenge for the radiological reading. They are not well-defined in both morphology (geometric shape) and kinetics (temporal enhancement) and pose a problem to lesion detection and classification. To enhance the discriminative properties of an automated radiological workflow, the correct preprocessing steps need to be taken. In an usual computer-aided diagnosis (CAD) system, motion compensation plays an important role. To this end, we employ a new high accuracy optical flow based motion compensation algorithm with robustification variants. An automated computer-aided diagnosis system evaluates the atypical behavior of these lesions, and additionally considers the impact of non-rigid motion compensation on a correct diagnosis.

  13. Computer Aided Measurement Laser (CAML): technique to quantify post-mastectomy lymphoedema

    Science.gov (United States)

    Trombetta, Chiara; Abundo, Paolo; Felici, Antonella; Ljoka, Concetta; Di Cori, Sandro; Rosato, Nicola; Foti, Calogero

    2012-10-01

    Lymphoedema can be a side effect of cancer treatment. Eventhough several methods for assessing lymphoedema are used in clinical practice, an objective quantification of lymphoedema has been problematic. The aim of the study was to determine the objectivity, reliability and repeatability of the computer aided measurement laser (CAML) technique. CAML technique is based on computer aided design (CAD) methods and requires an infrared laser scanner. Measurements are scanned and the information describing size and shape of the limb allows to design the model by using the CAD software. The objectivity and repeatability was established in the beginning using a phantom. Consequently a group of subjects presenting post-breast cancer lymphoedema was evaluated using as a control the contralateral limb. Results confirmed that in clinical settings CAML technique is easy to perform, rapid and provides meaningful data for assessing lymphoedema. Future research will include a comparison of upper limb CAML technique between healthy subjects and patients with known lymphoedema.

  14. Lead optimization attrition analysis (LOAA): a novel and general methodology for medicinal chemistry.

    Science.gov (United States)

    Munson, Mark; Lieberman, Harvey; Tserlin, Elina; Rocnik, Jennifer; Ge, Jie; Fitzgerald, Maria; Patel, Vinod; Garcia-Echeverria, Carlos

    2015-08-01

    Herein, we report a novel and general method, lead optimization attrition analysis (LOAA), to benchmark two distinct small-molecule lead series using a relatively unbiased, simple technique and commercially available software. We illustrate this approach with data collected during lead optimization of two independent oncology programs as a case study. Easily generated graphics and attrition curves enabled us to calibrate progress and support go/no go decisions on each program. We believe that this data-driven technique could be used broadly by medicinal chemists and management to guide strategic decisions during drug discovery. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. Computer-Aided Drug Design (CADD): Methodological Aspects and Practical Applications in Cancer Research

    Science.gov (United States)

    Gianti, Eleonora

    Computer-Aided Drug Design (CADD) has deservedly gained increasing popularity in modern drug discovery (Schneider, G.; Fechner, U. 2005), whether applied to academic basic research or the pharmaceutical industry pipeline. In this work, after reviewing theoretical advancements in CADD, we integrated novel and stateof- the-art methods to assist in the design of small-molecule inhibitors of current cancer drug targets, specifically: Androgen Receptor (AR), a nuclear hormone receptor required for carcinogenesis of Prostate Cancer (PCa); Signal Transducer and Activator of Transcription 5 (STAT5), implicated in PCa progression; and Epstein-Barr Nuclear Antigen-1 (EBNA1), essential to the Epstein Barr Virus (EBV) during latent infections. Androgen Receptor. With the aim of generating binding mode hypotheses for a class (Handratta, V.D. et al. 2005) of dual AR/CYP17 inhibitors (CYP17 is a key enzyme for androgens biosynthesis and therefore implicated in PCa development), we successfully implemented a receptor-based computational strategy based on flexible receptor docking (Gianti, E.; Zauhar, R.J. 2012). Then, with the ultimate goal of identifying novel AR binders, we performed Virtual Screening (VS) by Fragment-Based Shape Signatures, an improved version of the original method developed in our Laboratory (Zauhar, R.J. et al. 2003), and we used the results to fully assess the high-level performance of this innovative tool in computational chemistry. STAT5. The SRC Homology 2 (SH2) domain of STAT5 is responsible for phospho-peptide recognition and activation. As a keystone of Structure-Based Drug Design (SBDD), we characterized key residues responsible for binding. We also generated a model of STAT5 receptor bound to a phospho-peptide ligand, which was validated by docking publicly known STAT5 inhibitors. Then, we performed Shape Signatures- and docking-based VS of the ZINC database (zinc.docking.org), followed by Molecular Mechanics Generalized Born Surface Area (MMGBSA

  16. An Interrogative Model of Computer-Aided Adaptive Testing: Some Experimental Evidence

    Science.gov (United States)

    1988-09-01

    aquired knowledge. This thesis proposes and validates a computer-aided testing model called the Interrogative Diagnostic Model (IDM). The model is...PROGRAM DESIGN The design of a program to implement the model vas quite straight forvard. dB&8B III Plus vas the language selected for Implementation...true/false. Due to the inability of the dBASE III Plus in processing natural language essay type questions vere excluded. The content of the questions

  17. Review of research and development of computer-aided Kansei Engineering

    Institute of Scientific and Technical Information of China (English)

    Li LIN; Chengqi XUE

    2009-01-01

    Kansei Engineering is an important research approach and has become the hotspot of research in design fields. The concept of Kansei Engineering is introduced based on the investigation of related literatures. The working process and the key technology of computer-aided Kansei Engineering systems are discussed. Finally, the development trend of Kansei Engineering is outlined according to the development of computer and networking technology.

  18. Usability Studies in Virtual and Traditional Computer Aided Design Environments for Fault Identification

    Science.gov (United States)

    2017-08-08

    IDENTIFICATION) 1. Description In a typical design review process, a design space is presented to the reviewer(s) who examine the space for design ...Usability Studies In Virtual And Traditional Computer Aided Design Environments For Fault Identification Dr. Syed Adeel Ahmed, Xavier University...sacrificing accuracy. The research team timed each task, and recorded activity on evaluation sheets for Fault Identification Test. At the

  19. Usability Studies In Virtual And Traditional Computer Aided Design Environments For Spatial Awareness

    Science.gov (United States)

    2017-08-08

    Usability Studies In Virtual And Traditional Computer Aided Design Environments For Spatial Awareness Dr. Syed Adeel Ahmed, Xavier University of...sacrificing accuracy. The research team timed each task, and recorded activity on evaluation sheets for spatial awareness Test. At the completion of the...The significance and the detail description of this study is very well explained by Satter (2012) in his recent paper. Here we only present the

  20. Generic Mathematical Programming Formulation and Solution for Computer-Aided Molecular Design

    OpenAIRE

    2015-01-01

    This short communication presents a generic mathematical programming formulation for Computer-Aided Molecular Design (CAMD). A given CAMD problem, based on target properties, is formulated as a Mixed Integer Linear/Non-Linear Program (MILP/MINLP). The mathematical programming model presented here, which is formulated as an MILP/MINLP problem, considers first-order and second-order molecular groups for molecular structure representation and property estimation. It is shown that various CAMD pr...

  1. Design and Implementation of 3 Axis CNC Router for Computer Aided Manufacturing Courses

    OpenAIRE

    Aktan Mehmet Emin; Akkuş Nihat; Yılmaz Abdurrahman; Akdoğan Erhan

    2016-01-01

    In this paper, it is intended to make the mechanical design of 3 axis Computer Numerical Control (CNC) router with linear joints, production of electronic control interface cards and drivers and manufacturing of CNC router system which is a combination of mechanics and electronics. At the same time, interface program has been prepared to control router via USB. The router was developed for educational purpose. In some vocational schools and universities, Computer Aided Manufacturing (CAM) cou...

  2. APPLICATION OF INFORMATION AND COMMUNICATION TECHNOLOGIES IN COMPUTER AIDED LANGUAGE LEARNING

    Directory of Open Access Journals (Sweden)

    I. B. Tampel

    2013-01-01

    Full Text Available The article deals with the various ways of application for automatic speech recognition, Text-to-Speech technology, pronunciation and communication skills training, vocabulary check of the taught person, audition skills training in computer aided language learning (CALL-system. In spite of some constraints such technologies application is effective both for education problems simplification and for comfort growth of the system application.

  3. Computer Aided Diagnostic Support System for Skin Cancer: A Review of Techniques and Algorithms

    OpenAIRE

    Ammara Masood; Adel Ali Al-Jumaily

    2013-01-01

    Image-based computer aided diagnosis systems have significant potential for screening and early detection of malignant melanoma. We review the state of the art in these systems and examine current practices, problems, and prospects of image acquisition, pre-processing, segmentation, feature extraction and selection, and classification of dermoscopic images. This paper reports statistics and results from the most important implementations reported to date. We compared the performance of severa...

  4. Implementation Methods of Computer Aided Design-Drawing and Drawing Management for Plate Cutting-Machine

    Institute of Scientific and Technical Information of China (English)

    DONG Yu-de; ZHAO Han; TAN Jian-rong

    2002-01-01

    The implementation methods of computer aided design,drawing and drawing management for plate cuttingmachine are discussed. The system structure for plate cutting- machine design is put forward firstly, then some key technologies and their implementation methods are introduced, which include the structure management of graphics, the unification of graph and design calculation, information share of part, assemble and drawing management system, and movement simulation of key components.

  5. Integrating aerodynamic surface modeling for computational fluid dynamics with computer aided structural analysis, design, and manufacturing

    Science.gov (United States)

    Thorp, Scott A.

    1992-01-01

    This presentation will discuss the development of a NASA Geometry Exchange Specification for transferring aerodynamic surface geometry between LeRC systems and grid generation software used for computational fluid dynamics research. The proposed specification is based on a subset of the Initial Graphics Exchange Specification (IGES). The presentation will include discussion of how the NASA-IGES standard will accommodate improved computer aided design inspection methods and reverse engineering techniques currently being developed. The presentation is in viewgraph format.

  6. Computer aided morphometric analysis of oral leukoplakia and oral squamous cell carcinoma.

    Science.gov (United States)

    Gupta, K; Gupta, J; Miglani, R

    2016-01-01

    We compared the changes in the cells in the basal layer of normal mucosa, oral leukoplakia with dysplasia and different grades of oral squamous cell carcinoma (OSCC) using computer aided image analysis of tissue sections. We investigated three morphometric parameters: nuclear area (NA), cell area (CA) and their ratio (NA:CA). NA and NA:CA ratio showed a statistically significant increase from dysplasia to increasing grades of OSCC. Nuclear size was useful for differentiating normal tissue, potentially malignant leukoplakia and OSCC.

  7. Basic Principles of Industrial Electric Power Network Computer Aided Design and Engineering

    OpenAIRE

    M. Fursanov; I. Dul

    2012-01-01

    A conceptual model for a computer aided design and engineering system has been developed in the paper. The paper presents basic automation process principles including a graphical representation   network and calculation results, convenient user interface, automatic mode calculation, selection of transformer rated power and cross-section area of wires. The developed algorithm and program make it possible to save time and improve quality of project implementation.

  8. Computer-aided approach for customized cell-based defect reconstruction.

    Science.gov (United States)

    Meyer, Ulrich; Neunzehn, Jörg; Wiesmann, Hans Peter

    2012-01-01

    Computer-aided technologies like computer-aided design (CAD), computer-aided manufacturing (CAM), and a lot of other features like finite element method (FEM) have been recently employed for use in medical ways like in extracorporeal bone tissue engineering strategies. Aim of this pilot experimental study was to test whether autologous osteoblast-like cells cultured in vitro on individualized scaffolds can be used to support bone regeneration in a clinical environment. Mandibular bone defects were surgically introduced into the mandibles of Göttinger minipigs and the scaffold of the defect site was modelled by CAD/CAM techniques. From the minipigs harvested autologous bone cells from the porcine calvaria were cultivated in bioreactors. The cultured osteoblast-like cells were seeded on polylactic acid/polyglycolic acid (PLA/PGA) copolymer scaffolds being generated by rapid prototyping. The bone defects were then reconstructed by implanting these tissue-constructs into bone defects. The postoperative computerized topographic scans as well as the intraoperative sites demonstrated the accurate fit in the defect sites. The individual created, implanted scaffold constructs enriched with the porcine osteoblast-like cells were well tolerated and appeared to support bone formation, as revealed by immunohistochemical and histological analyses. The results of this investigations indicated that the in vitro expanded osteoblast-like cells spread on a resorbable individualized, computer-aided fabricated scaffold is capable of promoting the repair of bone tissue defects in vivo. The shown results warrant further attempts to combine computer modelling and tissue engineering for use in different ways in bone reconstructive surgery.

  9. On the Variety of Planar Spirals and Their Applications in Computer Aided Design

    Directory of Open Access Journals (Sweden)

    Kenjiro T. Miura

    2012-08-01

    Full Text Available In this paper we discuss the variety of planar spiral segments and their applications in objects in both the real and artificial world. The discussed curves with monotonic curvature function are well-known in geometric modelling and computer aided geometric design as fair curves, and they are very significant in aesthetic shape modelling. Fair curve segments are used for two-point G1 and G2 Hermite interpolation, as well as for generating aesthetic splines.

  10. Basic Principles of Industrial Electric Power Network Computer Aided Design and Engineering

    Directory of Open Access Journals (Sweden)

    M. Fursanov

    2012-01-01

    Full Text Available A conceptual model for a computer aided design and engineering system has been developed in the paper. The paper presents basic automation process principles including a graphical representation   network and calculation results, convenient user interface, automatic mode calculation, selection of transformer rated power and cross-section area of wires. The developed algorithm and program make it possible to save time and improve quality of project implementation.

  11. Case Based Reasoning Intelligent System for Network Computer Aided Process Planning

    Institute of Scientific and Technical Information of China (English)

    ZHAO Chunhua; WU Zhengjia; ZHOU Chengjun; ZHU Dalin; LI Haoping

    2006-01-01

    Computer aided process planning system played a key role for integrating design and manufacturing or assembly systems properly considering available resources and design constraints. To take advantage of the enterprise resource, the web CAPP framework was established. Case based reasoning and multi agent system were integrated in the system. The multi agent mechanism was discussed in the paper. And an instance of case base was introduced. They made the system run independently and continuously in the network environment of process planning problems.

  12. Unit cell-based computer-aided manufacturing system for tissue engineering.

    Science.gov (United States)

    Kang, Hyun-Wook; Park, Jeong Hun; Kang, Tae-Yun; Seol, Young-Joon; Cho, Dong-Woo

    2012-03-01

    Scaffolds play an important role in the regeneration of artificial tissues or organs. A scaffold is a porous structure with a micro-scale inner architecture in the range of several to several hundreds of micrometers. Therefore, computer-aided construction of scaffolds should provide sophisticated functionality for porous structure design and a tool path generation strategy that can achieve micro-scale architecture. In this study, a new unit cell-based computer-aided manufacturing (CAM) system was developed for the automated design and fabrication of a porous structure with micro-scale inner architecture that can be applied to composite tissue regeneration. The CAM system was developed by first defining a data structure for the computing process of a unit cell representing a single pore structure. Next, an algorithm and software were developed and applied to construct porous structures with a single or multiple pore design using solid freeform fabrication technology and a 3D tooth/spine computer-aided design model. We showed that this system is quite feasible for the design and fabrication of a scaffold for tissue engineering.

  13. Computer-aided diagnosis workstation and database system for chest diagnosis based on multihelical CT images

    Science.gov (United States)

    Sato, Hitoshi; Niki, Noboru; Mori, Kiyoshi; Eguchi, Kenji; Kaneko, Masahiro; Moriyama, Noriyuki; Ohmatsu, Hironobu; Kakinuma, Ryutaro; Masuda, Hideo; Machida, Suguru; Sasagawa, Michizou

    2004-04-01

    Lung cancer is the most common cause, accounting for about 20% of all cancer deaths for males in Japan. Myocardial infarction is also known as a most fearful adult disease. Recently, multi-helical CT scanner advanced remarkably at the speed at which the chest CT images were acquired for screening examination. This screening examination requires a considerable number of images to be read. It is this time-consuming step that makes the use of multi-helical CT for mass screening. To overcome this problem, our group has developed a computer-aided diagnosis algorithm to automatically detect suspicious regions of lung cancer and coronary calcifications in chest CT images, so far. And in this time, our group has developed a newly computer-aided diagnosis workstation and database. These consist in three. First, it is an image processing system to automatically detect suspicious bronchial regions, pulmonary artery regions, plumonary vein regions and myocardial infarction regions at high speed. Second, they are two 1600 x 1200 matrix black and white liquid crystal monitor. Third, it is a terminal of image storage. These are connected mutually on the network. This makes it much easier to read images, since the 3D image of suspicious regions and shadow of suspicious regions can be displayed simultaneously on two 1600 x 1200 matrix liquid crystal monitor. The experimental results indicate that a newly computer-aided diagnosis workstation and database system can be effectively used in clinical practice to increase the speed and accuracy of routine diagnosis.

  14. Eigenvalue-weighting and feature selection for computer-aided polyp detection in CT colonography

    Science.gov (United States)

    Zhu, Hongbin; Wang, Su; Fan, Yi; Lu, Hongbing; Liang, Zhengrong

    2010-03-01

    With the development of computer-aided polyp detection towards virtual colonoscopy screening, the trade-off between detection sensitivity and specificity has gained increasing attention. An optimum detection, with least number of false positives and highest true positive rate, is desirable and involves interdisciplinary knowledge, such as feature extraction, feature selection as well as machine learning. Toward that goal, various geometrical and textural features, associated with each suspicious polyp candidate, have been individually extracted and stacked together as a feature vector. However, directly inputting these high-dimensional feature vectors into a learning machine, e.g., neural network, for polyp detection may introduce redundant information due to feature correlation and induce the curse of dimensionality. In this paper, we explored an indispensable building block of computer-aided polyp detection, i.e., principal component analysis (PCA)-weighted feature selection for neural network classifier of true and false positives. The major concepts proposed in this paper include (1) the use of PCA to reduce the feature correlation, (2) the scheme of adaptively weighting each principal component (PC) by the associated eigenvalue, and (3) the selection of feature combinations via the genetic algorithm. As such, the eigenvalue is also taken as part of the characterizing feature, and the necessary number of features can be exposed to mitigate the curse of dimensionality. Learned and tested by radial basis neural network, the proposed computer-aided polyp detection has achieved 95% sensitivity at a cost of average 2.99 false positives per polyp.

  15. Computer-aided diagnosis workstation and network system for chest diagnosis based on multislice CT images

    Science.gov (United States)

    Satoh, Hitoshi; Niki, Noboru; Eguchi, Kenji; Moriyama, Noriyuki; Ohmatsu, Hironobu; Masuda, Hideo; Machida, Suguru

    2008-03-01

    Mass screening based on multi-helical CT images requires a considerable number of images to be read. It is this time-consuming step that makes the use of helical CT for mass screening impractical at present. To overcome this problem, we have provided diagnostic assistance methods to medical screening specialists by developing a lung cancer screening algorithm that automatically detects suspected lung cancers in helical CT images, a coronary artery calcification screening algorithm that automatically detects suspected coronary artery calcification and a vertebra body analysis algorithm for quantitative evaluation of osteoporosis likelihood by using helical CT scanner for the lung cancer mass screening. The function to observe suspicious shadow in detail are provided in computer-aided diagnosis workstation with these screening algorithms. We also have developed the telemedicine network by using Web medical image conference system with the security improvement of images transmission, Biometric fingerprint authentication system and Biometric face authentication system. Biometric face authentication used on site of telemedicine makes "Encryption of file" and Success in login" effective. As a result, patients' private information is protected. Based on these diagnostic assistance methods, we have developed a new computer-aided workstation and a new telemedicine network that can display suspected lesions three-dimensionally in a short time. The results of this study indicate that our radiological information system without film by using computer-aided diagnosis workstation and our telemedicine network system can increase diagnostic speed, diagnostic accuracy and security improvement of medical information.

  16. Lead

    Science.gov (United States)

    ... found? Who is at risk? What are the health effects of lead? Get educational material about lead Get certified as a Lead Abatement Worker, or other abatement discipline Lead in drinking water Lead air pollution Test your child Check and maintain your home ...

  17. Effect of different adhesive strategies on microtensile bond strength of computer aided design/computer aided manufacturing blocks bonded to dentin

    Science.gov (United States)

    Roperto, Renato; Akkus, Anna; Akkus, Ozan; Lang, Lisa; Sousa-Neto, Manoel Damiao; Teich, Sorin; Porto, Thiago Soares

    2016-01-01

    Background: The aim of this study was to determine the microtensile bond strength (μTBS) of ceramic and composite computer aided design-computer aided manufacturing (CAD-CAM) blocks bonded to dentin using different adhesive strategies. Materials and Methods: In this in vitro study, 30 crowns of sound freshly extracted human molars were sectioned horizontally 3 mm above the cementoenamel junction to produce flat dentin surfaces. Ceramic and composite CAD/CAM blocks, size 14, were sectioned into slices of 3 mm thick. Before bonding, CAD/CAM block surfaces were treated according to the manufacturer's instructions. Groups were created based on the adhesive strategy used: Group 1 (GI) - conventional resin cement + total-etch adhesive system, Group 2 (GII) - conventional resin cement + self-etch adhesive system, and Group 3 (GIII) - self-adhesive resin cement with no adhesive. Bonded specimens were stored in 100% humidity for 24h at 37΀C, and then sectioned with a slow-speed diamond saw to obtain 1 mm × 1 mm × 6 mm microsticks. Microtensile testing was then conducted using a microtensile tester. μTBS values were expressed in MPa and analyzed by one-way ANOVA with post hoc (Tukey) test at the 5% significance level. Results: Mean values and standard deviations of μTBS (MPa) were 17.68 (±2.71) for GI/ceramic; 17.62 (±3.99) for GI/composite; 13.61 (±6.92) for GII/composite; 12.22 (±4.24) for GII/ceramic; 7.47 (±2.29) for GIII/composite; and 6.48 (±3.10) for GIII/ceramic; ANOVA indicated significant differences among the adhesive modality and block interaction (P ceramic. Bond strength of GIII was consistently lower (P ceramic, can be significantly affected by different adhesive strategies used. PMID:27076825

  18. Evaluation of three-dimensional position change of the condylar head after orthognathic surgery using computer-aided design/computer-aided manufacturing-made condyle positioning jig.

    Science.gov (United States)

    Kim, Hyung-Mo; Baek, Seung-Hak; Kim, Tae-Yun; Choi, Jin-Young

    2014-11-01

    This study was performed to evaluate the efficacy of computer-aided design/computer-aided manufacturing (CAM/CAD)-made condyle positioning jig in orthognathic surgery. The sample consisted of 40 mandibular condyles of 20 patients with class III malocclusion who underwent bilateral sagittal split ramus osteotomy with semirigid fixation (6 men and 14 women; mean age, 25 y; mean amount of mandibular setback, 5.8 mm). Exclusion criteria were patients who needed surgical correction of the frontal ramal inclination and had signs and symptoms of the temporomandibular disorder before surgery. Three-dimensional computed tomograms were taken 1 month before the surgery (T1) and 1 day after the surgery (T2). The condylar position was evaluated at the T1 and T2 stages on the axial, frontal, and sagittal aspects in the three-dimensional coordinates. The linear change of the posterior border of the proximal segment of the ramus between T1 and T2 was also evaluated in 30 condyles (15 patients), with the exception of 10 condyles of 5 patients who received mandibular angle reduction surgery. There was no significant difference in the condylar position in the frontal and sagittal aspects (P > 0.05). Although there was a significant difference in the condylar position in the axial aspect (P < 0.01), the amount of difference was less than 1 mm and 1 degree; it can be considered clinically nonsignificant. In the linear change of the posterior border of the proximal segment of the ramus, the mean change was 1.4 mm and 60% of the samples showed a minimal change of less than 1 mm. The results of this study suggest that CAD/CAM-made condyle positioning jig is easy to install and reliable to use in orthognathic surgery.

  19. A feasibility trial of computer-aided diagnosis for enteric lesions in capsule endoscopy

    Institute of Scientific and Technical Information of China (English)

    Tao Gan; Jun-Chao Wu; Ni-Ni Rao; Tao Chen; Bing Liu

    2008-01-01

    AIM: To investigate and evaluate the feasibility of the computer-aided screening diagnosis for enteric lesions in the capsule endoscopy (CE).METHODS: After developing a series of algorithms for the screening diagnosis of the enteric lesions in CE based on their characteristic colors and contours,the normal and abnormal images obtained from 289 patients were respectively scanned and diagnosed by the CE readers and by the computer-aided screening for the enteric lesions with the image-processed software (IPS). The enteric lesions shown by the images included esoenteritis, mucosal ulcer and erosion, bleeding, spaceoccupying lesions, angioectasia, diverticula, parasites,etc. The images for the lesions or the suspected lesions confirmed by the CE readers and the computers were collected, and the effectiveness rate of the screening and the number of the scanned images were evaluated,respectively.RESULTS: Compared with the diagnostic results obtained by the CE readers, the total effectiveness rate (sensitivity) in the screening of the commonlyencountered enteric lesions by IPS varied from 42.9%to 91.2%, with a median of 74.2%, though the specificity and the accuracy rates were still low, and the images for the rarely-encountered lesions were difficult to differentiate from the normal images. However, the number of the images screened by IPS was 5000 on average, and only 10%-15% of the original images were left behind. As a result, a large number of normal images were excluded, and the reading time decreased from 5 h to 1 h on average.CONCLUSION: Though the total accuracy and specificity rates by the computer-aided screening for the enteric lesions with IPS are much lower than those by the CE readers, the computer-aided screening diagnosis can exclude a large number of the normal images and confine the enteric lesions to 5000 images on average,which can reduce the workload of the readers in the scanning of the images. This computer-aided screening technique can make a

  20. Coupling of Mechanical Behavior of Cell Components to Electrochemical-Thermal Models for Computer-Aided Engineering of Batteries under Abuse (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Pesaran, A.; Wierzbicki, T.; Sahraei, E.; Li, G.; Collins, L.; Sprague, M.; Kim, G. H.; Santhangopalan, S.

    2014-06-01

    The EV Everywhere Grand Challenge aims to produce plug-in electric vehicles as affordable and convenient for the American family as gasoline-powered vehicles by 2022. Among the requirements set by the challenge, electric vehicles must be as safe as conventional vehicles, and EV batteries must not lead to unsafe situations under abuse conditions. NREL's project started in October 2013, based on a proposal in response to the January 2013 DOE VTO FOA, with the goal of developing computer aided engineering tools to accelerate the development of safer lithium ion batteries.

  1. Computer-Aided Diagnosis in Mammography Using Content-Based Image Retrieval Approaches: Current Status and Future Perspectives

    Directory of Open Access Journals (Sweden)

    Bin Zheng

    2009-06-01

    Full Text Available As the rapid advance of digital imaging technologies, the content-based image retrieval (CBIR has became one of the most vivid research areas in computer vision. In the last several years, developing computer-aided detection and/or diagnosis (CAD schemes that use CBIR to search for the clinically relevant and visually similar medical images (or regions depicting suspicious lesions has also been attracting research interest. CBIR-based CAD schemes have potential to provide radiologists with “visual aid” and increase their confidence in accepting CAD-cued results in the decision making. The CAD performance and reliability depends on a number of factors including the optimization of lesion segmentation, feature selection, reference database size, computational efficiency, and relationship between the clinical relevance and visual similarity of the CAD results. By presenting and comparing a number of approaches commonly used in previous studies, this article identifies and discusses the optimal approaches in developing CBIR-based CAD schemes and assessing their performance. Although preliminary studies have suggested that using CBIR-based CAD schemes might improve radiologists’ performance and/or increase their confidence in the decision making, this technology is still in the early development stage. Much research work is needed before the CBIR-based CAD schemes can be accepted in the clinical practice.

  2. Topology optimization of compliant adaptive wing leading edge with composite materials

    Directory of Open Access Journals (Sweden)

    Tong Xinxing

    2014-12-01

    Full Text Available An approach for designing the compliant adaptive wing leading edge with composite material is proposed based on the topology optimization. Firstly, an equivalent constitutive relationship of laminated glass fiber reinforced epoxy composite plates has been built based on the symmetric laminated plate theory. Then, an optimization objective function of compliant adaptive wing leading edge was used to minimize the least square error (LSE between deformed curve and desired aerodynamics shape. After that, the topology structures of wing leading edge of different glass fiber ply-orientations were obtained by using the solid isotropic material with penalization (SIMP model and sensitivity filtering technique. The desired aerodynamics shape of compliant adaptive wing leading edge was obtained based on the proposed approach. The topology structures of wing leading edge depend on the glass fiber ply-orientation. Finally, the corresponding morphing experiment of compliant wing leading edge with composite materials was implemented, which verified the morphing capability of topology structure and illustrated the feasibility for designing compliant wing leading edge. The present paper lays the basis of ply-orientation optimization for compliant adaptive wing leading edge in unmanned aerial vehicle (UAV field.

  3. Research Development about Computer Aided Design of Shell and Tube Heat Exchanger%管壳式热交换器计算机辅助设计研究进展

    Institute of Scientific and Technical Information of China (English)

    王佳; 胡明辅; 钟浩文

    2013-01-01

    管壳式热交换器具有一些其他热交换器无法比拟的优点,在过程工业中处于主导地位.随着计算机技术发展,计算机辅助设计逐渐取代了以往繁杂的人工设计计算.综述了近年来管壳式热交换器计算机辅助设计的研究进展,从国内、国外两方面介绍了最新的计算机辅助设计软件,并简要分析了管壳式热交换器计算机辅助设计发展中存在的一些问题.%Shell and tube heat exchanger play the leading role in process industry, because they have some advantages that others can't exceed. With the development of the computer, the computer aided design gradually replaced the multifarious conventional design. The research and development about computer aided design of shell and tube heat exchanger recently were summarized, and the newest computer aided software in both local and foreign was introduced. Some problems in the development about computer aided design of shell and tube heat exchanger were briefly analyzed.

  4. A New Optimization Model for Computer-Aided Molecular Design Problems

    DEFF Research Database (Denmark)

    Zhang, Lei; Cignitti, Stefano; Gani, Rafiqul

    as known molecules with desired properties. The attention is in particular targeted at the design of chemical based products, such as solvents, refrigerants, active pharmaceutical ingredients, polymers, surfactants, lubricants, and more [1]. Property prediction methods are needed in molecular design...... to be determined. In this way, CAMD problems can be formulated as a Mixed Integer Linear/Non-Linear Program (MILP/MINLP). With the advent of connectivity-based prediction methods, several researchers have developed new strategies for embedding it with CAMD method. Constantinou et al. [2] proposed a systematic...

  5. Database Design Methodology and Database Management System for Computer-Aided Structural Design Optimization.

    Science.gov (United States)

    1984-12-01

    1983). Several researchers Lillehagen and Dokkar (1982), Grabowski, Eigener and Ranch (1978), and Eberlein and Wedekind (1982) have worked on database...Proceedings of International Federation of Information Processing. pp. 335-366. Eberlein, W. and Wedekind , H., 1982, "A Methodology for Embedding Design

  6. Computer-aided interactive structural optimization of printed-circuit-board design

    Science.gov (United States)

    Duncan, L. B.; Holman, R. E.; Lagasse, B. K.; Sakamoto, L. W.; Sunada, W. H.

    Electronic equipment operating in severe vibration environments plays a critical role in military and aerospace hardware. A crucial element of most modularized electronic equipment is the printed circuit board (PCB). Structural failures of such boards are almost entirely the result of imposed mechanical vibration. It is desirable to incorporate structural guidelines and analysis techniques at an early stage in board development when deficiencies may easily be corrected. However, there are a number of problems connected with such an approach. A computer program has been developed to address the considered situation. The program is to reduce PCB structural analysis to a level readily understood by the average designer. Another objective of the program is to encourage use of structural analysis at an early stage of PCB design and development. Attention is given to board geometry, program organization, board response computation, and a sample problem.

  7. Discovery and computer aided potency optimization of a novel class of small molecule CXCR4 antagonists.

    Directory of Open Access Journals (Sweden)

    Victoria Vinader

    Full Text Available Amongst the chemokine signalling axes involved in cancer, chemokine CXCL12 acting on chemokine receptor CXCR4 is particularly significant since it orchestrates migration of cancer cells in a tissue-specific metastatic process. High CXCR4 tumour expression is associated with poor prognosis of lung, brain, CNS, blood and breast cancers. We have identified a new class of small molecule CXCR4 antagonists based on the use of computational modelling studies in concert with experimental determination of in vitro activity against CXCL12-induced intracellular calcium mobilisation, proliferation and chemotaxis. Molecular modelling proved to be a useful tool in rationalising our observed potencies, as well as informing the direction of the synthetic efforts aimed at producing more potent compounds.

  8. Optimization of Breast Tomosynthesis Imaging Systems for Computer-Aided Detection

    Science.gov (United States)

    2011-05-01

    digital mammography have been used for over 30 years in the early detection of cancer . The combination of screening and adjuvant therapies have led to...a decrease in the mortality rate from breast cancer [1]. Because mammography projects a three-dimensional object onto a two-dimensional surface...Update from 2009 [25]. A.3. Angle-dependent detector response: Two different detectors were modeled: gadolinium oxysulfide (Gd2O2S) and cesium iodide

  9. Computer-aided design of the RF-cavity for a high-power S-band klystron

    Science.gov (United States)

    Kant, D.; Bandyopadhyay, A. K.; Pal, D.; Meena, R.; Nangru, S. C.; Joshi, L. M.

    2012-08-01

    This article describes the computer-aided design of the RF-cavity for a S-band klystron operating at 2856 MHz. State-of-the-art electromagnetic simulation tools SUPERFISH, CST Microwave studio, HFSS and MAGIC have been used for cavity design. After finalising the geometrical details of the cavity through simulation, it has been fabricated and characterised through cold testing. Detailed results of the computer-aided simulation and cold measurements are presented in this article.

  10. Efficient Inventory Optimization of Multi Product, Multiple Suppliers with Lead Time using PSO

    CERN Document Server

    Narmadha, S; Sathish, G

    2010-01-01

    With information revolution, increased globalization and competition, supply chain has become longer and more complicated than ever before. These developments bring supply chain management to the forefront of the managements attention. Inventories are very important in a supply chain. The total investment in inventories is enormous, and the management of inventory is crucial to avoid shortages or delivery delays for the customers and serious drain on a companys financial resources. The supply chain cost increases because of the influence of lead times for supplying the stocks as well as the raw materials. Practically, the lead times will not be same through out all the periods. Maintaining abundant stocks in order to avoid the impact of high lead time increases the holding cost. Similarly, maintaining fewer stocks because of ballpark lead time may lead to shortage of stocks. This also happens in the case of lead time involved in supplying raw materials. A better optimization methodology that utilizes the Part...

  11. Accuracy evaluation of metal copings fabricated by computer-aided milling and direct metal laser sintering systems.

    Science.gov (United States)

    Park, Jong-Kyoung; Lee, Wan-Sun; Kim, Hae-Young; Kim, Woong-Chul; Kim, Ji-Hwan

    2015-04-01

    To assess the marginal and internal gaps of the copings fabricated by computer-aided milling and direct metal laser sintering (DMLS) systems in comparison to casting method. Ten metal copings were fabricated by casting, computer-aided milling, and DMLS. Seven mesiodistal and labiolingual positions were then measured, and each of these were divided into the categories; marginal gap (MG), cervical gap (CG), axial wall at internal gap (AG), and incisal edge at internal gap (IG). Evaluation was performed by a silicone replica technique. A digital microscope was used for measurement of silicone layer. Statistical analyses included one-way and repeated measure ANOVA to test the difference between the fabrication methods and categories of measured points (α=.05), respectively. The mean gap differed significantly with fabrication methods (P<.001). Casting produced the narrowest gap in each of the four measured positions, whereas CG, AG, and IG proved narrower in computer-aided milling than in DMLS. Thus, with the exception of MG, all positions exhibited a significant difference between computer-aided milling and DMLS (P<.05). Although the gap was found to vary with fabrication methods, the marginal and internal gaps of the copings fabricated by computer-aided milling and DMLS fell within the range of clinical acceptance (<120 µm). However, the statistically significant difference to conventional casting indicates that the gaps in computer-aided milling and DMLS fabricated restorations still need to be further reduced.

  12. Computer-aided diagnosis of leukoencephalopathy in children treated for acute lymphoblastic leukemia

    Science.gov (United States)

    Glass, John O.; Li, Chin-Shang; Helton, Kathleen J.; Reddick, Wilburn E.

    2005-04-01

    The purpose of this study was to use objective quantitative MR imaging methods to develop a computer-aided diagnosis tool to differentiate white matter (WM) hyperintensities as either leukoencephalopathy (LE) or normal maturational processes in children treated for acute lymphoblastic leukemia with intravenous high dose methotrexate. A combined imaging set consisting of T1, T2, PD, and FLAIR MR images and WM, gray matter, and cerebrospinal fluid a priori maps from a spatially normalized atlas were analyzed with a neural network segmentation based on a Kohonen Self-Organizing Map. Segmented regions were manually classified to identify the most hyperintense WM region and the normal appearing genu region. Signal intensity differences normalized to the genu within each examination were generated for two time points in 203 children. An unsupervised hierarchical clustering algorithm with the agglomeration method of McQuitty was used to divide data from the first examination into normal appearing or LE groups. A C-support vector machine (C-SVM) was then trained on the first examination data and used to classify the data from the second examination. The overall accuracy of the computer-aided detection tool was 83.5% (299/358) with sensitivity to normal WM of 86.9% (199/229) and specificity to LE of 77.5% (100/129) when compared to the readings of two expert observers. These results suggest that subtle therapy-induced leukoencephalopathy can be objectively and reproducibly detected in children treated for cancer using this computer-aided detection approach based on relative differences in quantitative signal intensity measures normalized within each examination.

  13. Deep-learning convolution neural network for computer-aided detection of microcalcifications in digital breast tomosynthesis

    Science.gov (United States)

    Samala, Ravi K.; Chan, Heang-Ping; Hadjiiski, Lubomir M.; Cha, Kenny; Helvie, Mark A.

    2016-03-01

    A deep learning convolution neural network (DLCNN) was designed to differentiate microcalcification candidates detected during the prescreening stage as true calcifications or false positives in a computer-aided detection (CAD) system for clustered microcalcifications. The microcalcification candidates were extracted from the planar projection image generated from the digital breast tomosynthesis volume reconstructed by a multiscale bilateral filtering regularized simultaneous algebraic reconstruction technique. For training and testing of the DLCNN, true microcalcifications are manually labeled for the data sets and false positives were obtained from the candidate objects identified by the CAD system at prescreening after exclusion of the true microcalcifications. The DLCNN architecture was selected by varying the number of filters, filter kernel sizes and gradient computation parameter in the convolution layers, resulting in a parameter space of 216 combinations. The exhaustive grid search method was used to select an optimal architecture within the parameter space studied, guided by the area under the receiver operating characteristic curve (AUC) as a figure-of-merit. The effects of varying different categories of the parameter space were analyzed. The selected DLCNN was compared with our previously designed CNN architecture for the test set. The AUCs of the CNN and DLCNN was 0.89 and 0.93, respectively. The improvement was statistically significant (p < 0.05).

  14. Design of an enhanced fuzzy k-nearest neighbor classifier based computer aided diagnostic system for thyroid disease.

    Science.gov (United States)

    Liu, Da-You; Chen, Hui-Ling; Yang, Bo; Lv, Xin-En; Li, Li-Na; Liu, Jie

    2012-10-01

    In this paper, we present an enhanced fuzzy k-nearest neighbor (FKNN) classifier based computer aided diagnostic (CAD) system for thyroid disease. The neighborhood size k and the fuzzy strength parameter m in FKNN classifier are adaptively specified by the particle swarm optimization (PSO) approach. The adaptive control parameters including time-varying acceleration coefficients (TVAC) and time-varying inertia weight (TVIW) are employed to efficiently control the local and global search ability of PSO algorithm. In addition, we have validated the effectiveness of the principle component analysis (PCA) in constructing a more discriminative subspace for classification. The effectiveness of the resultant CAD system, termed as PCA-PSO-FKNN, has been rigorously evaluated against the thyroid disease dataset, which is commonly used among researchers who use machine learning methods for thyroid disease diagnosis. Compared to the existing methods in previous studies, the proposed system has achieved the highest classification accuracy reported so far via 10-fold cross-validation (CV) analysis, with the mean accuracy of 98.82% and with the maximum accuracy of 99.09%. Promisingly, the proposed CAD system might serve as a new candidate of powerful tools for diagnosing thyroid disease with excellent performance.

  15. Zygomatico-maxillary Reconstruction with Computer-aided Manufacturing of a Free DCIA Osseous Flap and Intraoral Anastomoses

    Science.gov (United States)

    Roy, Andrée-Anne; Efanov, Johnny I.; Mercier-Couture, Geneviève; Chollet, André

    2017-01-01

    Summary: Craniomaxillofacial reconstruction using virtual surgical planning, computer-aided manufacturing, and new microsurgical techniques optimizes patient-specific and defect-directed reconstruction. A 3D customized free deep circumflex iliac artery (DCIA) flap with intraoral anastomoses was performed on a 23-year-old man with a posttraumatic right zygomatico-maxillary defect with failure of alloplastic implant reconstruction. An osseous iliac crest flap was sculpted based on a customized 3D model of the mirror image of the patient’s unaffected side to allow for perfect fit to the zygomatico-maxillary defect. An intraoral dissection of the facial artery and vein was performed within the right cheek mucosa and allowed for end-to-end microvascular anastomoses. 3D preoperative planning and customized free DCIA osseous flap combined with an intraoral microsurgical technique provided restoration of facial esthetics and function without visible scars. In cases where zygomatico-malar reconstruction by alloplastic material fails, a customized free DCIA osseous flap can be designed by virtual surgical planning to restore facial appearance and function.

  16. A behavior-based inverse kinematics algorithm to predict arm prehension postures for computer-aided ergonomic evaluation.

    Science.gov (United States)

    Wang, X

    1999-05-01

    In this paper, the computational problem of inverse kinematics of arm prehension movements was investigated. How motions of each joint involved in arm movements can be used to control the end-effector (hand) position and orientation was first examined. It is shown that the inverse kinematics problem due to the kinematic redundancy in joint space is ill-posed only at the control of hand orientation but not at the control of hand position. Based upon this analysis, a previously proposed inverse kinematics algorithm (Wang et Verriest, 1998a) to predict arm reach postures was extended to a seven-DOF arm model to predict arm prehension postures using a separate control of hand position and orientation. The algorithm can be either in rule-based form or by optimization through appropriate choice of weight coefficients. Compared to the algebraic inverse kinematics algorithm, the proposed algorithm can handle the non-linearity of joint limits in a straightforward way. In addition, no matrix inverse calculation is needed, thus avoiding the stability and convergence problems often occurring near a singularity of the Jacobian. Since an end-effector motion-oriented method is used to describe joint movements, observed behaviors of arm movements can be easily implemented in the algorithm. The proposed algorithm provides a general frame for arm postural control and can be used as an efficient postural manipulation tool for computer-aided ergonomic evaluation.

  17. Development of problem-oriented software packages for numerical studies and computer-aided design (CAD) of gyrotrons

    Science.gov (United States)

    Damyanova, M.; Sabchevski, S.; Zhelyazkov, I.; Vasileva, E.; Balabanova, E.; Dankov, P.; Malinov, P.

    2016-03-01

    Gyrotrons are the most powerful sources of coherent CW (continuous wave) radiation in the frequency range situated between the long-wavelength edge of the infrared light (far-infrared region) and the microwaves, i.e., in the region of the electromagnetic spectrum which is usually called the THz-gap (or T-gap), since the output power of other devices (e.g., solid-state oscillators) operating in this interval is by several orders of magnitude lower. In the recent years, the unique capabilities of the sub-THz and THz gyrotrons have opened the road to many novel and future prospective applications in various physical studies and advanced high-power terahertz technologies. In this paper, we present the current status and functionality of the problem-oriented software packages (most notably GYROSIM and GYREOSS) used for numerical studies, computer-aided design (CAD) and optimization of gyrotrons for diverse applications. They consist of a hierarchy of codes specialized to modelling and simulation of different subsystems of the gyrotrons (EOS, resonant cavity, etc.) and are based on adequate physical models, efficient numerical methods and algorithms.

  18. Computer-aided detection of pulmonary nodules using dynamic self-adaptive template matching and a FLDA classifier.

    Science.gov (United States)

    Gong, Jing; Liu, Ji-Yu; Wang, Li-Jia; Zheng, Bin; Nie, Sheng-Dong

    2016-12-01

    Improving the performance of computer-aided detection (CAD) system for pulmonary nodules is still an important issue for its future clinical applications. This study aims to develop a new CAD scheme for pulmonary nodule detection based on dynamic self-adaptive template matching and Fisher linear discriminant analysis (FLDA) classifier. We first segment and repair lung volume by using OTSU algorithm and three-dimensional (3D) region growing. Next, the suspicious regions of interest (ROIs) are extracted and filtered by applying 3D dot filtering and thresholding method. Then, pulmonary nodule candidates are roughly detected with 3D dynamic self-adaptive template matching. Finally, we optimally select 11 image features and apply FLDA classifier to reduce false positive detections. The performance of the new method is validated by comparing with other methods through experiments using two groups of public datasets from Lung Image Database Consortium (LIDC) and ANODE09. By a 10-fold cross-validation experiment, the new CAD scheme finally has achieved a sensitivity of 90.24% and a false-positive (FP) of 4.54 FP/scan on average for the former dataset, and a sensitivity of 84.1% with 5.59 FP/scan for the latter. By comparing with other previously reported CAD schemes tested on the same datasets, the study proves that this new scheme can yield higher and more robust results in detecting pulmonary nodules.

  19. Feasibility Study of a Generalized Framework for Developing Computer-Aided Detection Systems-a New Paradigm.

    Science.gov (United States)

    Nemoto, Mitsutaka; Hayashi, Naoto; Hanaoka, Shouhei; Nomura, Yukihiro; Miki, Soichiro; Yoshikawa, Takeharu

    2017-04-12

    We propose a generalized framework for developing computer-aided detection (CADe) systems whose characteristics depend only on those of the training dataset. The purpose of this study is to show the feasibility of the framework. Two different CADe systems were experimentally developed by a prototype of the framework, but with different training datasets. The CADe systems include four components; preprocessing, candidate area extraction, candidate detection, and candidate classification. Four pretrained algorithms with dedicated optimization/setting methods corresponding to the respective components were prepared in advance. The pretrained algorithms were sequentially trained in the order of processing of the components. In this study, two different datasets, brain MRA with cerebral aneurysms and chest CT with lung nodules, were collected to develop two different types of CADe systems in the framework. The performances of the developed CADe systems were evaluated by threefold cross-validation. The CADe systems for detecting cerebral aneurysms in brain MRAs and for detecting lung nodules in chest CTs were successfully developed using the respective datasets. The framework was shown to be feasible by the successful development of the two different types of CADe systems. The feasibility of this framework shows promise for a new paradigm in the development of CADe systems: development of CADe systems without any lesion specific algorithm designing.

  20. An automated tuberculosis screening strategy combining X-ray-based computer-aided detection and clinical information

    Science.gov (United States)

    Melendez, Jaime; Sánchez, Clara I.; Philipsen, Rick H. H. M.; Maduskar, Pragnya; Dawson, Rodney; Theron, Grant; Dheda, Keertan; van Ginneken, Bram

    2016-04-01

    Lack of human resources and radiological interpretation expertise impair tuberculosis (TB) screening programmes in TB-endemic countries. Computer-aided detection (CAD) constitutes a viable alternative for chest radiograph (CXR) reading. However, no automated techniques that exploit the additional clinical information typically available during screening exist. To address this issue and optimally exploit this information, a machine learning-based combination framework is introduced. We have evaluated this framework on a database containing 392 patient records from suspected TB subjects prospectively recruited in Cape Town, South Africa. Each record comprised a CAD score, automatically computed from a CXR, and 12 clinical features. Comparisons with strategies relying on either CAD scores or clinical information alone were performed. Our results indicate that the combination framework outperforms the individual strategies in terms of the area under the receiving operating characteristic curve (0.84 versus 0.78 and 0.72), specificity at 95% sensitivity (49% versus 24% and 31%) and negative predictive value (98% versus 95% and 96%). Thus, it is believed that combining CAD and clinical information to estimate the risk of active disease is a promising tool for TB screening.

  1. Cardiac resynchronization therapy: Dire need for targeted left ventricular lead placement and optimal device programming

    Institute of Scientific and Technical Information of China (English)

    Sokratis; Pastromas; Antonis; S; Manolis

    2014-01-01

    Cardiac resynchronization therapy(CRT) effected via biventricular pacing has been established as prime therapy for heart failure patients of New York Heart Association functional class Ⅱ, Ⅲ and ambulatory Ⅳ, reduced left ventricular(LV) function, and a widened QRS complex. CRT has been shown to improve symptoms, LV function, hospitalization rates, and survival. In order to maximize the benefit from CRT and reduce the number of non-responders, consideration should be given to target the optimal site for LV lead implantation away from myocardial scar and close to the latest LV site activation; and also to appropriately program the device paying particular attention to optimal atrioventricular and interventricular intervals. We herein review current data related to both optimal LV lead placement and device programming and their effects on CRT clinical outcomes.

  2. Assess/Mitigate Risk through the Use of Computer-Aided Software Engineering (CASE) Tools

    Science.gov (United States)

    Aguilar, Michael L.

    2013-01-01

    The NASA Engineering and Safety Center (NESC) was requested to perform an independent assessment of the mitigation of the Constellation Program (CxP) Risk 4421 through the use of computer-aided software engineering (CASE) tools. With the cancellation of the CxP, the assessment goals were modified to capture lessons learned and best practices in the use of CASE tools. The assessment goal was to prepare the next program for the use of these CASE tools. The outcome of the assessment is contained in this document.

  3. Generic Mathematical Programming Formulation and Solution for Computer-Aided Molecular Design

    DEFF Research Database (Denmark)

    Zhang, Lei; Cignitti, Stefano; Gani, Rafiqul

    2015-01-01

    This short communication presents a generic mathematical programming formulation for Computer-Aided Molecular Design (CAMD). A given CAMD problem, based on target properties, is formulated as a Mixed Integer Linear/Non-Linear Program (MILP/MINLP). The mathematical programming model presented here......, which is formulated as an MILP/MINLP problem, considers first-order and second-order molecular groups for molecular structure representation and property estimation. It is shown that various CAMD problems can be formulated and solved through this model....

  4. Computer-aided design studies of the homopolar linear synchronous motor

    Science.gov (United States)

    Dawson, G. E.; Eastham, A. R.; Ong, R.

    1984-09-01

    The linear induction motor (LIM), as an urban transit drive, can provide good grade-climbing capabilities and propulsion/braking performance that is independent of steel wheel-rail adhesion. In view of its 10-12 mm airgap, the LIM is characterized by a low power factor-efficiency product of order 0.4. A synchronous machine offers high efficiency and controllable power factor. An assessment of the linear homopolar configuration of this machine is presented as an alternative to the LIM. Computer-aided design studies using the finite element technique have been conducted to identify a suitable machine design for urban transit propulsion.

  5. Computer-Aided Analysis of Patents for Product Technology Maturity Forecasting

    Science.gov (United States)

    Liang, Yanhong; Gan, Dequan; Guo, Yingchun; Zhang, Peng

    Product technology maturity foresting is vital for any enterprises to hold the chance for innovation and keep competitive for a long term. The Theory of Invention Problem Solving (TRIZ) is acknowledged both as a systematic methodology for innovation and a powerful tool for technology forecasting. Based on TRIZ, the state -of-the-art on the technology maturity of product and the limits of application are discussed. With the application of text mining and patent analysis technologies, this paper proposes a computer-aided approach for product technology maturity forecasting. It can overcome the shortcomings of the current methods.

  6. Computer-aided diagnosis of pulmonary diseases using x-ray darkfield radiography

    DEFF Research Database (Denmark)

    Einarsdottir, Hildur; Yaroshenko, Andre; Velroyen, Astrid;

    2015-01-01

    In this work we develop a computer-aided diagnosis (CAD) scheme for classification of pulmonary disease for grating-based x-ray radiography. In addition to conventional transmission radiography, the grating-based technique provides a dark-field imaging modality, which utilizes the scattering...... of three stages: (i) automatic lung segmentation; (ii) feature extraction from lung shape and dark-field image intensities; (iii) classification between healthy, emphysema and fibrosis lungs. A study of 102 mice was conducted with 34 healthy, 52 emphysema and 16 fibrosis subjects. Each image was manually...

  7. Metalloporphyrin catalysts for oxygen reduction developed using computer-aided molecular design

    Energy Technology Data Exchange (ETDEWEB)

    Ryba, G.N.; Hobbs, J.D.; Shelnutt, J.A. [and others

    1996-04-01

    The objective of this project is the development of a new class of metalloporphyrin materials used as catalsyts for use in fuel cell applications. The metalloporphyrins are excellent candidates for use as catalysts at both the anode and cathode. The catalysts reduce oxygen in 1 M potassium hydroxide, as well as in 2 M sulfuric acid. Covalent attachment to carbon supports is being investigated. The computer-aided molecular design is an iterative process, in which experimental results feed back into the design of future catalysts.

  8. Computer-Aided Design System for CP Single-Screw Compressor

    Institute of Scientific and Technical Information of China (English)

    SHEN Jing-feng; YAO Fu-sheng

    2006-01-01

    To design various optimum parameters and simulate the working process of CP single-screw compressor,the Computer-Aided Design(CAD)system for the CP singlescrew compressor has been established.A new method based on computer graphics technology,database technology,object-oriented programming technology,and visual simulation technology has been adopted in this CAD system.The system has integrated solid modeling function with parameterization design function and animator simulation function based on analyzing the working principle of the CP single-screw compressor.The experimental results show fhat the CAD system for the CP single-screw compressor is practical and feasible.

  9. A REVIEW ON DISEASES MANIFESTATION BY OCULAR DISEASES USING COMPUTER AIDED DIAGNOSIS (CAD

    Directory of Open Access Journals (Sweden)

    Ridza Azri Ramlee

    2015-08-01

    Full Text Available The use of eye for diagnosis for detecting the disease has been used long time ago. However, for conventional medical practitioners this procedure are used to detect diseases that cause vision problems. This method is widely used by practitioners of alternative medicine that uses the eyes to detect the presence of disease, such as iridology practitioners. In this paper we study the method adopted by the researchers based on conventional and alternative medical practitioners to detect the presence of disease using a computer-aided diagnosis (CAD or automatically

  10. Defining Spaces of Potential Art: The significance of representation in computer-aided creativity

    DEFF Research Database (Denmark)

    Dahlstedt, Palle

    2005-01-01

    One way of looking at the creative process is as a search in a space of possible answers. One way of simulating such a process is through evolutionary algorithms, i.e., simulated evolution by random variation and selection. The search space is defined by the chosen genetic representation, a kind...... of formal description, and the ways of navigating the space are defined by the choice of genetic operators (e.g., mutations). In creative systems, such as computer-aided music composition tools, these choices determine the efficiency of the system, in terms of the diversity of the results, the degree...

  11. Generic Mathematical Programming Formulation and Solution for Computer-Aided Molecular Design

    DEFF Research Database (Denmark)

    Zhang, Lei; Cignitti, Stefano; Gani, Rafiqul

    2015-01-01

    This short communication presents a generic mathematical programming formulation for Computer-Aided Molecular Design (CAMD). A given CAMD problem, based on target properties, is formulated as a Mixed Integer Linear/Non-Linear Program (MILP/MINLP). The mathematical programming model presented here......, which is formulated as an MILP/MINLP problem, considers first-order and second-order molecular groups for molecular structure representation and property estimation. It is shown that various CAMD problems can be formulated and solved through this model....

  12. Computer aided diagnosis for breast masses detection on a telemammography system.

    Science.gov (United States)

    Méndez, Arturo J; Souto, Miguel; Tahoces, Pablo G; Vidal, Juan J

    2003-01-01

    A Computer-Aided Diagnosis (CAD) scheme for breast masses detection has been developed and integrated as a part of a telemammography system. This work derives from the close cooperation between the Laboratory for Radiologic Image Research of the University of Santiago de Compostela (Spain) and the company Intelsis Sistemas Inteligentes (Santiago de Compostela, Spain). This cooperation has been supported by funds from different projects, mainly from the European Union, the Spanish Health Administration, and the Galician Public Health's Service. As a result, a first prototype is ready to begin a demonstration project.

  13. A Simple and Resource-efficient Setup for the Computer-aided Drug Design Laboratory.

    Science.gov (United States)

    Moretti, Loris; Sartori, Luca

    2016-10-01

    Undertaking modelling investigations for Computer-Aided Drug Design (CADD) requires a proper environment. In principle, this could be done on a single computer, but the reality of a drug discovery program requires robustness and high-throughput computing (HTC) to efficiently support the research. Therefore, a more capable alternative is needed but its implementation has no widespread solution. Here, the realization of such a computing facility is discussed, from general layout to technical details all aspects are covered. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Implementation of Locally Weighted Projection Regression Network for Concurrency Control In Computer Aided Design

    Directory of Open Access Journals (Sweden)

    A.Muthukumaravel

    2011-08-01

    Full Text Available This paper presents implementation of locally weighted projection regression (LWPR network method for concurrency control while developing dial of a fork using Autodesk inventor 2008. The LWPR learns the objects and the type of transactions to be done based on which node in the output layer of the network exceeds a threshold value. Learning stops once all the objects are exposed to LWPR. During testing performance, metrics are analyzed. We have attempted to use LWPR for storing lock information when multi users are working on computer Aided Design (CAD. The memory requirements of the proposed method are minimal in processing locks during transaction.

  15. Computer-aided diagnosis of HIE based on segmentation of MRI

    Science.gov (United States)

    Sun, Ziguang; Li, Chungui; Wang, Qin

    2009-10-01

    Computer-aided diagnosis has become one of the major research subjects in medical imaging and diagnostic radiology. Hypoxic-ischemic encephalopathy (HIE), remains a serious condition that causes significant mortality and long-term morbidity to neonates. We adopt self-organizing feature maps to segment the tissues, such as white matter and grey matter in the magnetic resonance images. The borderline between white matter and grey matter can be found and the doubtful regions along with the borderline can be localized, then the feature in doubtful regions can be quantified. The method can assist doctors to easily diagnose whether a neonate is ill with mild HIE.

  16. Computer-Aided Diagnosis Systems for Brain Diseases in Magnetic Resonance Images

    Directory of Open Access Journals (Sweden)

    Yasuo Yamashita

    2009-07-01

    Full Text Available This paper reviews the basics and recent researches of computer-aided diagnosis (CAD systems for assisting neuroradiologists in detection of brain diseases, e.g., asymptomatic unruptured aneurysms, Alzheimer's disease, vascular dementia, and multiple sclerosis (MS, in magnetic resonance (MR images. The CAD systems consist of image feature extraction based on image processing techniques and machine learning classifiers such as linear discriminant analysis, artificial neural networks, and support vector machines. We introduce useful examples of the CAD systems in the neuroradiology, and conclude with possibilities in the future of the CAD systems for brain diseases in MR images.

  17. Computer-aided methods for analysis and synthesis of supersonic cruise aircraft structures

    Science.gov (United States)

    Giles, G. L.

    1976-01-01

    Computer-aided methods are reviewed which are being developed by Langley Research Center in-house work and by related grants and contracts. Synthesis methods to size structural members to meet strength and stiffness (flutter) requirements are emphasized and described. Because of the strong interaction among the aerodynamic loads, structural stiffness, and member sizes of supersonic cruise aircraft structures, these methods are combined into systems of computer programs to perform design studies. The approaches used in organizing these systems to provide efficiency, flexibility of use in an iterative process, and ease of system modification are discussed.

  18. RETRACTED: Auricular prosthesis fabrication using computer-aided design and rapid prototyping technologies.

    Science.gov (United States)

    Shah, Mayank

    2016-06-01

    At the request of the editorMayank Shah 'Auricular prosthesis fabrication using computer-aided design and rapid prototyping technologies' Prosthetics and Orthotics International, published online before print on October 8, 2013 as doi:10.1177/0309364613504779has been retracted. This is because it contains unattributed overlap withK. Subburaj, C. Nair, S. Rajesh, S. M. Meshram, B. Ravi 'Rapid development of auricular prosthesis using CAD and rapid prototyping technologies' International Journal of Oral & Maxillofacial Surgery 2007; 36: 938-943 doi:10.1016/j.ijom.2007.07.013. © The International Society for Prosthetics and Orthotics 2014.

  19. Model-based computer-aided design for controlled release of pesticides

    DEFF Research Database (Denmark)

    Muro Sunè, Nuria; Gani, Rafiqul; Bell, G.;

    2005-01-01

    In the field of controlled release technology for pesticides or active ingredients (AI), models that can predict its delivery during application are important for purposes of design and marketing of the pesticide product. Appropriate models for the controlled release of pesticides, if available, ...... extended models have been developed and implemented into a computer-aided system. The total model consisting of the property models embedded into the release models are then employed to study the release of different combinations of AIs and polymer-based microcapsules....

  20. Computer Aided Methods & Tools for Separation & Purification of Fine Chemical & Pharmaceutical Products

    DEFF Research Database (Denmark)

    Afonso, Maria B.C.; Soni, Vipasha; Mitkowski, Piotr Tomasz

    2006-01-01

    aided system. The methods and tools are linked through the problems they are able to solve and the associated data-flow. The integrated computer aided system has been used to solve a number of industrial problems and summarized results from a selection, involving separation and purification issues......An integrated approach that is particularly suitable for solving problems related to product-process design from the fine chemicals, agrochemicals, food and pharmaceutical industries is presented together with the corresponding methods and tools, which forms the basis for an integrated computer...

  1. Computer-Aided Image Analysis and Fractal Synthesis in the Quantitative Evaluation of Tumor Aggressiveness in Prostate Carcinomas.

    Science.gov (United States)

    Waliszewski, Przemyslaw

    2016-01-01

    The subjective evaluation of tumor aggressiveness is a cornerstone of the contemporary tumor pathology. A large intra- and interobserver variability is a known limiting factor of this approach. This fundamental weakness influences the statistical deterministic models of progression risk assessment. It is unlikely that the recent modification of tumor grading according to Gleason criteria for prostate carcinoma will cause a qualitative change and improve significantly the accuracy. The Gleason system does not allow the identification of low aggressive carcinomas by some precise criteria. The ontological dichotomy implies the application of an objective, quantitative approach for the evaluation of tumor aggressiveness as an alternative. That novel approach must be developed and validated in a manner that is independent of the results of any subjective evaluation. For example, computer-aided image analysis can provide information about geometry of the spatial distribution of cancer cell nuclei. A series of the interrelated complexity measures characterizes unequivocally the complex tumor images. Using those measures, carcinomas can be classified into the classes of equivalence and compared with each other. Furthermore, those measures define the quantitative criteria for the identification of low- and high-aggressive prostate carcinomas, the information that the subjective approach is not able to provide. The co-application of those complexity measures in cluster analysis leads to the conclusion that either the subjective or objective classification of tumor aggressiveness for prostate carcinomas should comprise maximal three grades (or classes). Finally, this set of the global fractal dimensions enables a look into dynamics of the underlying cellular system of interacting cells and the reconstruction of the temporal-spatial attractor based on the Taken's embedding theorem. Both computer-aided image analysis and the subsequent fractal synthesis could be performed

  2. Associating Drugs, Targets and Clinical Outcomes into an Integrated Network Affords a New Platform for Computer-Aided Drug Repurposing.

    Science.gov (United States)

    Oprea, Tudor I; Nielsen, Sonny Kim; Ursu, Oleg; Yang, Jeremy J; Taboureau, Olivier; Mathias, Stephen L; Kouskoumvekaki, Lrene; Sklar, Larry A; Bologa, Cristian G

    2011-03-14

    Finding new uses for old drugs is a strategy embraced by the pharmaceutical industry, with increasing participation from the academic sector. Drug repurposing efforts focus on identifying novel modes of action, but not in a systematic manner. With intensive data mining and curation, we aim to apply bio- and cheminformatics tools using the DRUGS database, containing 3,837 unique small molecules annotated on 1,750 proteins. These are likely to serve as drug targets and antitargets (i.e., associated with side effects, SE). The academic community, the pharmaceutical sector and clinicians alike could benefit from an integrated, semantic-web compliant computer-aided drug repurposing (CADR) effort, one that would enable deep data mining of associations between approved drugs (D), targets (T), clinical outcomes (CO) and SE. We report preliminary results from text mining and multivariate statistics, based on 7,684 approved drug labels, ADL (Dailymed) via text mining. From the ADL corresponding to 988 unique drugs, the "adverse reactions" section was mapped onto 174 SE, then clustered via principal component analysis into a 5x5 self-organizing map that was integrated into a Cytoscape network of SE-D-T-CO. This type of data can be used to streamline drug repurposing and may result in novel insights that can lead to the identification of novel drug actions.

  3. A Study of the Use of Ontologies for Building Computer-Aided Control Engineering Self-Learning Educational Software

    Science.gov (United States)

    García, Isaías; Benavides, Carmen; Alaiz, Héctor; Alonso, Angel

    2013-08-01

    This paper describes research on the use of knowledge models (ontologies) for building computer-aided educational software in the field of control engineering. Ontologies are able to represent in the computer a very rich conceptual model of a given domain. This model can be used later for a number of purposes in different software applications. In this study, domain ontology about the field of lead-lag compensator design has been built and used for automatic exercise generation, graphical user interface population and interaction with the user at any level of detail, including explanations about why things occur. An application called Onto-CELE (ontology-based control engineering learning environment) uses the ontology for implementing a learning environment that can be used for self and lifelong learning purposes. The experience has shown that the use of knowledge models as the basis for educational software applications is capable of showing students the whole complexity of the analysis and design processes at any level of detail. A practical experience with postgraduate students has shown the mentioned benefits and possibilities of the approach.

  4. Effects of Computer-Aided Manufacturing Technology on Precision of Clinical Metal-Free Restorations

    Directory of Open Access Journals (Sweden)

    Ki-Hong Lee

    2015-01-01

    Full Text Available Purpose. The purpose of this study was to investigate the marginal fit of metal-free crowns made by three different computer-aided design/computer-aided manufacturing (CAD/CAM systems. Materials and Methods. The maxillary left first premolar of a dentiform was prepared for all-ceramic crown restoration. Thirty all-ceramic premolar crowns were made, ten each manufactured by the Lava system, Cercon, and Cerec. Ten metal ceramic gold (MCG crowns served as control. The marginal gap of each sample was measured under a stereoscopic microscope at 75x magnification after cementation. One-way ANOVA and the Duncan’s post hoc test were used for data analysis at the significance level of 0.05. Results. The mean (standard deviation marginal gaps were 70.5 (34.4 μm for the MCG crowns, 87.2 (22.8 μm for Lava, 58.5 (17.6 μm for Cercon, and 72.3 (30.8 μm for Cerec. There were no significant differences in the marginal fit among the groups except that the Cercon crowns had significantly smaller marginal gaps than the Lava crowns (P<0.001.  Conclusions. Within the limitation of this study, all the metal-free restorations made by the digital CAD/CAM systems had clinically acceptable marginal accuracy.

  5. Computer Aided Instruction (CAI) for the Shipboard Nontactical ADP Program (SNAP). Interim report

    Energy Technology Data Exchange (ETDEWEB)

    Duncan, L.D.; Hammons, C.E.; Hume, R.; Christian, J.; Handler B.H.; Phillips, J.

    1986-01-01

    Oak Ridge National Laboratory is developing a prototype computer aided instruction package for the Navy Management Systems Support Office. This report discusses the background of the project and the progress to date including a description of the software design, problems encountered, solutions found, and recommendations. The objective of this project is to provide a prototype that will enhance training and can be used as a shipboard refresher and retraining tool. The prototype system will be installed onboard ships where Navy personnel will have ready access to the training. The subsequent testing and evaluation of the prototype could provide the basis for a Navy-wide effort to implement computer aided instruction. The work to date has followed a rigorous structured analysis methodology based on the Yourdon/DeMarco techniques. A set of data flow diagrams and a data dictionary are included in the appendices. The problems encountered revolve around requirements to use existing hardware, software, and programmer capabilities for development, implementation, and maintenance of the instructional software. Solutions have been developed which will allow the software to exist in the given environment and still provide advanced features not available in commercial courses.

  6. Computer-aided Detection of Prostate Cancer with MRI: Technology and Applications.

    Science.gov (United States)

    Liu, Lizhi; Tian, Zhiqiang; Zhang, Zhenfeng; Fei, Baowei

    2016-08-01

    One in six men will develop prostate cancer in his lifetime. Early detection and accurate diagnosis of the disease can improve cancer survival and reduce treatment costs. Recently, imaging of prostate cancer has greatly advanced since the introduction of multiparametric magnetic resonance imaging (mp-MRI). Mp-MRI consists of T2-weighted sequences combined with functional sequences including dynamic contrast-enhanced MRI, diffusion-weighted MRI, and magnetic resonance spectroscopy imaging. Because of the big data and variations in imaging sequences, detection can be affected by multiple factors such as observer variability and visibility and complexity of the lesions. To improve quantitative assessment of the disease, various computer-aided detection systems have been designed to help radiologists in their clinical practice. This review paper presents an overview of literatures on computer-aided detection of prostate cancer with mp-MRI, which include the technology and its applications. The aim of the survey is threefold: an introduction for those new to the field, an overview for those working in the field, and a reference for those searching for literature on a specific application.

  7. Fabrication of tissue engineered tympanic membrane patches using computer-aided design and injection molding.

    Science.gov (United States)

    Hott, Morgan E; Megerian, Cliff A; Beane, Rich; Bonassar, Lawrence J

    2004-07-01

    The goal of the current study was to use computer-aided design and injection molding technologies to tissue engineer precisely shaped cartilage in the shape of butterfly tympanic membrane patches out of chondrocyte-seeded calcium alginate gels. Molds were designed on SolidWorks 2000 and built out of acrylonitrile butadiene styrene (ABS) using fused deposition modeling (FDM). Tympanic membrane patches were fabricated using bovine articular chondrocytes seeded at 50 x 10 cells/mL in 2% calcium alginate gels. Molded patches were cultured in vitro for up to 10 weeks and assessed biochemically, morphologically, and histologically. Unmolded patches demonstrated outstanding dimensional fidelity, with a volumetric precision of at least 3 microL, and maintained their shape well for up to 10 weeks of in vitro culture. Glycosaminoglycan and collagen content increased steadily over 10 weeks in culture, demonstrating continual deposition of new extracellular matrix consistent with new tissue development. The use of computer-aided design and injection molding technologies allows for the fabrication of very small, precisely shaped chondrocyte-seeded calcium alginate structures that faithfully maintain their shape during in vitro culture. In vitro fabrication of tympanic membrane patches with a precisely controlled geometry may have the potential to provide a minimally invasive alternative to traditional methods for the repair of chronic tympanic membrane perforations.

  8. Computer aided segmentation of kidneys using locally shape constrained deformable models on CT images

    Science.gov (United States)

    Erdt, Marius; Sakas, Georgios

    2010-03-01

    This work presents a novel approach for model based segmentation of the kidney in images acquired by Computed Tomography (CT). The developed computer aided segmentation system is expected to support computer aided diagnosis and operation planning. We have developed a deformable model based approach based on local shape constraints that prevents the model from deforming into neighboring structures while allowing the global shape to adapt freely to the data. Those local constraints are derived from the anatomical structure of the kidney and the presence and appearance of neighboring organs. The adaptation process is guided by a rule-based deformation logic in order to improve the robustness of the segmentation in areas of diffuse organ boundaries. Our work flow consists of two steps: 1.) a user guided positioning and 2.) an automatic model adaptation using affine and free form deformation in order to robustly extract the kidney. In cases which show pronounced pathologies, the system also offers real time mesh editing tools for a quick refinement of the segmentation result. Evaluation results based on 30 clinical cases using CT data sets show an average dice correlation coefficient of 93% compared to the ground truth. The results are therefore in most cases comparable to manual delineation. Computation times of the automatic adaptation step are lower than 6 seconds which makes the proposed system suitable for an application in clinical practice.

  9. Computer-aided Molecular Design of Compounds Targeting Histone Modifying Enzymes.

    Science.gov (United States)

    Andreoli, Federico; Del Rio, Alberto

    2015-01-01

    Growing evidences show that epigenetic mechanisms play crucial roles in the genesis and progression of many physiopathological processes. As a result, research in epigenetic grew at a fast pace in the last decade. In particular, the study of histone post-translational modifications encountered an extraordinary progression and many modifications have been characterized and associated to fundamental biological processes and pathological conditions. Histone modifications are the catalytic result of a large set of enzyme families that operate covalent modifications on specific residues at the histone tails. Taken together, these modifications elicit a complex and concerted processing that greatly contribute to the chromatin remodeling and may drive different pathological conditions, especially cancer. For this reason, several epigenetic targets are currently under validation for drug discovery purposes and different academic and industrial programs have been already launched to produce the first pre-clinical and clinical outcomes. In this scenario, computer-aided molecular design techniques are offering important tools, mainly as a consequence of the increasing structural information available for these targets. In this mini-review we will briefly discuss the most common types of known histone modifications and the corresponding operating enzymes by emphasizing the computer-aided molecular design approaches that can be of use to speed-up the efforts to generate new pharmaceutically relevant compounds.

  10. Diagnóstico auxiliado por computador na radiologia Computer-aided diagnosis in radiology

    Directory of Open Access Journals (Sweden)

    Paulo Mazzoncini de Azevedo-Marques

    2001-10-01

    Full Text Available Vários desenvolvimentos tecnológicos estão convergindo de forma a aumentar a influência da área de imagens nas pesquisas biomédicas e na medicina clínica. Muitos pesquisadores têm trabalhado no desenvolvimento de sistemas computadorizados para detecção automatizada e quantificação de anormalidades em imagens radiológicas. Estes sistemas são dedicados ao diagnóstico auxiliado por computador. Este artigo discute os conceitos básicos relacionados ao diagnóstico auxiliado por computador e apresenta uma revisão bibliográfica sobre o assunto.Several technological developments are contributing to increase the use of imaging techniques in biomedical research and clinical medicine. Many investigators have attempted to develop computerized routines for automated detection and quantitative analysis of abnormalities in radiological images. These routines have been referred to as computer-aided diagnosis. In this paper we discuss the basic concepts of computer-aided diagnosis and review the literature.

  11. Computer-aided formative assessment considering as example the CAMPUS system for teaching and learning

    Directory of Open Access Journals (Sweden)

    Sütterlin, Thomas

    2006-11-01

    Full Text Available Due to the “Approbationsordnung für Ärzte“ in Germany, it is mandatory that medical curricula and their courses are designed in a problem-oriented and case-based way. Therefore it is necessary to carry out problem-oriented and case-based assessments. The evaluation of computer-aided formative assessments is introduced and explained by a concept that was developed in a master theses at Heidelberg and Heilbronn University by an approbated physician. The categorisation of medical actions plays an essential role in this concept. The available categories depend on the type of the medical action. A prototype was developed in order to demonstrate the concept on the basis of the evaluation of a CAMPUS case treatment. The applicability of the software for formative assessments was confirmed by the future users. These proposed that the user should have the possibility to comment every single medical action in order to give a direct feedback. At first the use of computer-aided formative assessment is planned for assessments with a lower level of importance in order to evaluate the usability of the software.

  12. Design and fabrication of facial prostheses for cancer patient applying computer aided method and manufacturing (CADCAM)

    Science.gov (United States)

    Din, Tengku Noor Daimah Tengku; Jamayet, Nafij; Rajion, Zainul Ahmad; Luddin, Norhayati; Abdullah, Johari Yap; Abdullah, Abdul Manaf; Yahya, Suzana

    2016-12-01

    Facial defects are either congenital or caused by trauma or cancer where most of them affect the person appearance. The emotional pressure and low self-esteem are problems commonly related to patient with facial defect. To overcome this problem, silicone prosthesis was designed to cover the defect part. This study describes the techniques in designing and fabrication for facial prosthesis applying computer aided method and manufacturing (CADCAM). The steps of fabricating the facial prosthesis were based on a patient case. The patient was diagnosed for Gorlin Gotz syndrome and came to Hospital Universiti Sains Malaysia (HUSM) for prosthesis. The 3D image of the patient was reconstructed from CT data using MIMICS software. Based on the 3D image, the intercanthal and zygomatic measurements of the patient were compared with available data in the database to find the suitable nose shape. The normal nose shape for the patient was retrieved from the nasal digital library. Mirror imaging technique was used to mirror the facial part. The final design of facial prosthesis including eye, nose and cheek was superimposed to see the result virtually. After the final design was confirmed, the mould design was created. The mould of nasal prosthesis was printed using Objet 3D printer. Silicone casting was done using the 3D print mould. The final prosthesis produced from the computer aided method was acceptable to be used for facial rehabilitation to provide better quality of life.

  13. Development of computer-aided functions in clinical neurosurgery with PACS

    Science.gov (United States)

    Mukasa, Minoru; Aoki, Makoto; Satoh, Minoru; Kowada, Masayoshi; Kikuchi, K.

    1991-07-01

    The introduction of the "Picture Archiving and Communications System (known as PACS)," provides many benefits, including the application of C.A.D., (Computer Aided Diagnosis). Clinically, this allows for the measurement and design of an operation to be easily completed with the CRT monitors of PACS rather than with film, as has been customary in the past. Under the leadership of the Department of Neurosurgery, Akita University School of Medicine, and Southern Tohoku Research Institute for Neuroscience, Koriyama, new computer aided functions with EFPACS (Fuji Electric's PACS) have been developed for use in clinical neurosurgery. This image processing is composed of three parts as follows: (1) Automatic mapping of small lesions depicted on Magnetic Resonance (or MR) images on the brain atlas. (2) Superimposition of two angiographic films onto a single synthesized image. (3) Automatic mapping of the lesion's position (as shown on the. CT images) on the processing image referred to in the foregoing clause 2. The processing in the clause (1) provides a reference for anatomical estimation. The processing in the clause (2) is used for general analysis of the condition of a disease. The processing in the clause (3) is used to design the operation. This image processing is currently being used with good results.

  14. Computer aided modeling and simulation of hydroforming on tubular engineering products

    Directory of Open Access Journals (Sweden)

    Jeremy (Zheng Li

    2013-01-01

    Full Text Available Hydroforming processes have been widely applied in many different industrial fields including aerospace, automotive, and modern plastics for weight-reduction and strength enhancement. Hydroforming on tubular products is better than the process of welding tubular assemblies from stampings including increased strength, reduction of work applied to the unit weight, decreased processing and tool costs, improved structural stability, less secondary operation, enhanced stiffness, and more uniform in product thickness. Although the hydroforming becomes popular manufacturing methodology, few researches have been done to study the hydroforming mechanism through computational modeling and simulation. This paper focuses on the study of hydroforming process and mechanism based on computer-aided modeling (FEA and prototype testing to determine the material behaviors in hydroforming process. The objective of this research is to verify the effects of major manufacturing parameters on hydroforming processes. The computational analysis and prototype testing indicate that some factors including applied internal pressure path and compressive axial loading play important roles in hydroforming deformation. Both computer-aided modeling and prototyping experiment show close results which verifies the credibility of this research and analytic methodology.

  15. Computer-aided diagnosis of interstitial lung disease: a texture feature extraction and classification approach

    Science.gov (United States)

    Vargas-Voracek, Rene; McAdams, H. Page; Floyd, Carey E., Jr.

    1998-06-01

    An approach for the classification of normal or abnormal lung parenchyma from selected regions of interest (ROIs) of chest radiographs is presented for computer aided diagnosis of interstitial lung disease (ILD). The proposed approach uses a feed-forward neural network to classify each ROI based on a set of isotropic texture measures obtained from the joint grey level distribution of pairs of pixels separated by a specific distance. Two hundred ROIs, each 64 X 64 pixels in size (11 X 11 mm), were extracted from digitized chest radiographs for testing. Diagnosis performance was evaluated with the leave-one-out method. Classification of independent ROIs achieved a sensitivity of 90% and a specificity of 84% with an area under the receiver operating characteristic curve of 0.85. The diagnosis for each patient was correct for all cases when a `majority vote' criterion for the classification of the corresponding ROIs was applied to issue a normal or ILD patient classification. The proposed approach is a simple, fast, and consistent method for computer aided diagnosis of ILD with a very good performance. Further research will include additional cases, including differential diagnosis among ILD manifestations.

  16. Computer-aided diagnosis of prostate cancer with emphasis on ultrasound-based approaches: a review.

    Science.gov (United States)

    Moradi, Mehdi; Mousavi, Parvin; Abolmaesumi, Purang

    2007-07-01

    This paper reviews the state of the art in computer-aided diagnosis of prostate cancer and focuses, in particular, on ultrasound-based techniques for detection of cancer in prostate tissue. The current standard procedure for diagnosis of prostate cancer, i.e., ultrasound-guided biopsy followed by histopathological analysis of tissue samples, is invasive and produces a high rate of false negatives resulting in the need for repeated trials. It is against these backdrops that the search for new methods to diagnose prostate cancer continues. Image-based approaches (such as MRI, ultrasound and elastography) represent a major research trend for diagnosis of prostate cancer. Due to the integration of ultrasound imaging in the current clinical procedure for detection of prostate cancer, we specifically provide a more detailed review of methodologies that use ultrasound RF-spectrum parameters, B-scan texture features and Doppler measures for prostate tissue characterization. We present current and future directions of research aimed at computer-aided detection of prostate cancer and conclude that ultrasound is likely to play an important role in the field.

  17. Exploring Effectiveness of Computer-Aided Planning in Implant Positioning for a Single Immediate Implant Placement.

    Science.gov (United States)

    Edelmann, Alexander R; Hosseini, Bashir; Byrd, Warren C; Preisser, John S; Tyndall, Donald A; Nguyen, Tung; Bencharit, Sompop

    2016-06-01

    The value of computer-aided implant planning using cone-beam computerized tomography (CBCT) for single immediate implants was explored. Eighteen patients requiring extraction of a tooth followed by a single immediate implant were enrolled. Small volume preoperative CBCT scans were used to plan the position of the implant. A taper screwed-type implant was immediately placed into a fresh socket using only the final 1 or 2 drills for osteotomy. Postoperative CBCTs were used for the analysis of actual implant placement positioning. Measurements of the planned and the actual implant position were made with respect to their position relative to the adjacent teeth. Mesio-distal displacements and the facial-lingual deviation of the implant from the planned position were determined. Changes in the angulation of the planned and actual implant position in relation to the clinical crown were also measured. To statistically summarize the results, box plots and 95% CIs for means of paired differences were used. The analysis showed no statistical difference between the planned position and final implant placement position in any measurement. The CBCT scans coupled with the computer-aided implant planning program along with a final 1-to-2 drill protocol may improve the accuracy of single immediate implant placement for taper screwed-type implants.

  18. Lead

    Science.gov (United States)

    ... Chapter 6 Chapter 7 Chapter 8 Chapter 9 Appendix I Appendix II Tables Figures State Programs Alabama Alaska Arizona ... Tool Kit Resources Healthy Homes and Lead Poisoning Prevention Training Center (HHLPPTC) Training Tracks File Formats Help: ...

  19. Computer-aided detection for computed tomographic colonography screening: a prospective comparison of a double-reading paradigm with first-reader computer-aided detection against second-reader computer-aided detection.

    Science.gov (United States)

    Iussich, Gabriella; Correale, Loredana; Senore, Carlo; Hassan, Cesare; Segnan, Nereo; Campanella, Delia; Bert, Alberto; Galatola, Giovanni; Laudi, Cristiana; Regge, Daniele

    2014-03-01

    The objective of this study was to prospectively compare diagnostic performance and time efficiency of a double-reading paradigm in which a first-reader computer-aided detection (CAD) is followed by a fast 2-dimensional review (DR FR-CAD) with those of a double reading with second-reader CAD (SR CAD). The local ethical committee approved this study. Consecutive immunological patients who have positive results for fecal immunological test who were scheduled for colonoscopy were enrolled for a 10-month period. Computed tomographic colonography studies were read with CAD (CAD COLON-1.20; im3D, Turin, Italy) by using both SR CAD (applied after unassisted interpretation primary 2-dimensional) and DR FR-CAD (CAD-prompts evaluation followed by a fast 2-dimensional review) in randomized order with the radiologist for each reading paradigm masked to the other reader's results.Per-patient sensitivity and specificity of unassisted and CAD-assisted readings for detecting 6-mm adenomas or larger were calculated by using unblinding colonoscopy as reference standard. Reporting times were also calculated. Pairwise comparisons were performed. A total of 182 participants (median age, 65 years; range, 58-76) were included in the final analysis. Of these, 93 (51%) had at least 1 cancer or a 6-mm adenoma or larger. At the 6-mm threshold, sensitivity of unassisted reading (79.6%; 95% confidence interval [CI], 69.9-87.2) increased significantly with the use of both SR CAD (86.0%; 95% CI, 77.3%-92.3%) and DR FR-CAD (89.2%; 95% CI, 81.1%-94.7%), without differences between CAD readings (P = 0.500). No significant differences in specificity among the 3 paradigms were observed. Double reading with first-reader CAD required less reading time than that for SR CAD (378 vs 496; Δ118 seconds; P reader CAD is followed by a fast 2-dimensional review improves the adenoma detection rate to the same level achieved by a second-reader CAD while decreasing reporting times.

  20. THE EFFECT OF WEB-BASED COMPUTER-AIDED ART EDUCATION TO ACADEMIC SUCCESS BY CONSTRUCTIVIST APPROACH

    Directory of Open Access Journals (Sweden)

    Adnan TEPECIK

    2014-11-01

    Full Text Available The general objective of this study is to examine the effect of the “Web Based Computer Aided Teaching” activity which is prepared according to the structural approach on the academic success of the students who study art at graduate level. With this study, interactive education material has been prepared for the web based computer aided teaching and teaching activity has been carried out with two separate student groups. One group has been subjected to the traditional teaching method, and the other has been subjected to the web based computer aided teaching. The success and the learning persistency of the students after the application have been examined. “Multiple subject – one factor experimental pattern” among the experimental models has been used as the pattern in the study. In this respect, the study has been carried out on the pattern with the pretest-posttest control group. A significant increase has been seen in the academic successes of the students who participated in the Web Based Computer Aided teaching applications when compared to the academic successes of the students who participated in the Traditional Teaching method. It has been revealed that the actions in the test group are more effective than those in the control group. Relying on the obtained results, it can be suggested that new studies can be carried out including the web based computer aided teaching applications for different lessons in the field of art education.

  1. Computer Aided Diagnosis for Confocal Laser Endomicroscopy in Advanced Colorectal Adenocarcinoma.

    Directory of Open Access Journals (Sweden)

    Daniela Ştefănescu

    Full Text Available Confocal laser endomicroscopy (CLE is becoming a popular method for optical biopsy of digestive mucosa for both diagnostic and therapeutic procedures. Computer aided diagnosis of CLE images, using image processing and fractal analysis can be used to quantify the histological structures in the CLE generated images. The aim of this study is to develop an automatic diagnosis algorithm of colorectal cancer (CRC, based on fractal analysis and neural network modeling of the CLE-generated colon mucosa images.We retrospectively analyzed a series of 1035 artifact-free endomicroscopy images, obtained during CLE examinations from normal mucosa (356 images and tumor regions (679 images. The images were processed using a computer aided diagnosis (CAD medical imaging system in order to obtain an automatic diagnosis. The CAD application includes image reading and processing functions, a module for fractal analysis, grey-level co-occurrence matrix (GLCM computation module, and a feature identification module based on the Marching Squares and linear interpolation methods. A two-layer neural network was trained to automatically interpret the imaging data and diagnose the pathological samples based on the fractal dimension and the characteristic features of the biological tissues.Normal colon mucosa is characterized by regular polyhedral crypt structures whereas malignant colon mucosa is characterized by irregular and interrupted crypts, which can be diagnosed by CAD. For this purpose, seven geometric parameters were defined for each image: fractal dimension, lacunarity, contrast correlation, energy, homogeneity, and feature number. Of the seven parameters only contrast, homogeneity and feature number were significantly different between normal and cancer samples. Next, a two-layer feed forward neural network was used to train and automatically diagnose the malignant samples, based on the seven parameters tested. The neural network operations were cross

  2. Computer Aided Multi-scale Design of SiC-Si3N4 Nanoceramic Composites for High-Temperature Structural Applications

    Energy Technology Data Exchange (ETDEWEB)

    Vikas Tomer; John Renaud

    2010-08-31

    temperature dependent strength and microstructural stability was also significantly depended upon the dispersion of new phases at grain boundaries. The material design framework incorporates high temperature creep and mechanical strength data in order to develop a collaborative multiscale framework of morphology optimization. The work also incorporates a computer aided material design dataset development procedure where a systematic dataset on material properties and morphology correlation could be obtained depending upon a material processing scientist's requirements. Two different aspects covered under this requirement are: (1) performing morphology related analyses at the nanoscale and at the microscale to develop a multiscale material design and analyses capability; (2) linking material behavior analyses with the developed design tool to form a set of material design problems that illustrate the range of material design dataset development that could be performed. Overall, a software based methodology to design microstructure of particle based ceramic nanocomposites has been developed. This methodology has been shown to predict changes in phase morphologies required for achieving optimal balance of conflicting properties such as minimal creep strain rate and high fracture strength at high temperatures. The methodology incorporates complex material models including atomistic approaches. The methodology will be useful to design materials for high temperature applications including those of interest to DoE while significantly reducing cost of expensive experiments.

  3. Optimal forming zone length in continuous extrusion of lead-clad glass fiber wire

    Institute of Scientific and Technical Information of China (English)

    李霞; 唐景林; 王丽薇; 高明

    2008-01-01

    Forming zone length (FZL) is a key parameter of the lead-clad glass fiber extrusion dies, and an unsuitable FZL will lead to breakage of the glass fiber and/or unacceptable geometric and metallographic qualities of the product. The optimal FZL was determined theoretically based on a mathematical model established by upper bound method, and accepted Pb-GF wire was actually obtained experimentally by symmetric side-feed extrusion at a much lower temperature than that published before. The wire has features of fine grains, uniform diameter, good coaxiality and satisfied mechanical property. The results and conclusions obtained in the research can be used to design the forming tools for lead-clad glass fiber extrusion and have significance to further research on the extrusion of other complex wires of metal-clad brittle core.

  4. Development of a computer-aided diagnostic system for Alzheimer's disease using magnetic resonance imaging

    CERN Document Server

    Murase, Kenya; Soma, Tsutomu

    2016-01-01

    Alzheimer's disease (AD) is the most common type of dementia accompanied with brain atrophy. Structural measurements of brain atrophy in specific brain structures such as hippocampus using magnetic resonance imaging (MRI) have been reported to detect the development of dementia early in the course of the disease. The purpose of this study was to develop a computer-aided diagnostic system for AD using MRI, which is based on the automatic volumetry of segmented brain images and generation of three-dimensional cortical thickness images using the Eulerian partial differential equation (PDE) approach. We investigated the effect of the inhomogeneity of magnetic field strength and statistical noise on the accuracy of our automatic volumetry and the PDE approach using the simulated MR images generated from BrainWeb. Our automatic volumetry and PDE approach were robust against inhomogeneous magnetic field strength. Although the accuracy of our automatic volumetry decreased with increasing statistical noise, it was mai...

  5. Computer aided process planning and die design in simulation environment in sheet metal forming

    Science.gov (United States)

    Tisza, Miklós; Lukács, Zsolt

    2013-12-01

    During the recent 10-15 years, Computer Aided Process Planning and Die Design evolved as one of the most important engineering tools in sheet metal forming, particularly in the automotive industry. This emerging role is strongly emphasized by the rapid development of Finite Element Modeling, as well. The purpose of this paper is to give a general overview about the recent achievements in this very important field of sheet metal forming and to introduce some special results in this development activity. Therefore, in this paper, an integrated process simulation and die design system developed at the University of Miskolc, Department of Mechanical Engineering will be analyzed. The proposed integrated solutions have great practical importance to improve the global competitiveness of sheet metal forming in the very important segment of industry. The concept described in this paper may have specific value both for process planning and die design engineers.

  6. 6th International Workshop on Computer-Aided Scheduling of Public Transport

    CERN Document Server

    Branco, Isabel; Paixão, José

    1995-01-01

    This proceedings volume consists of papers presented at the Sixth International Workshop on Computer-Aided Scheduling of Public Transpon, which was held at the Fund~lio Calouste Gulbenkian in Lisbon from July 6th to 9th, 1993. In the tradition of alternating Workshops between North America and Europe - Chicago (1975), Leeds (1980), Montreal (1983), Hamburg (1987) and again Montreal (1990), the European city of Lisbon was selected as the venue for the Workshop in 1993. As in earlier Workshops, the central theme dealt with vehicle and duty scheduling problems and the employment of operations-research-based software systems for operational planning in public transport. However, as was initiated in Hamburg in 1987, the scope of this Workshop was broadened to include topics in related fields. This fundamental alteration was an inevitable consequence of the growing demand over the last decade for solutions to the complete planning process in public transport through integrated systems. Therefore, the program of thi...

  7. Computer-aided detection of small bowel strictures in CT enterography

    Science.gov (United States)

    Sainani, Nisha I.; Näppi, Janne J.; Sahani, Dushyant V.; Yoshida, Hiroyuki

    2011-03-01

    The workflow of CT enterography in an emergency setting could be improved significantly by computer-aided detection (CAD) of small bowel strictures to enable even non-expert radiologists to detect sites of obstruction rapidly. We developed a CAD scheme to detect strictures automatically from abdominal multi-detector CT enterography image data by use of multi-scale template matching and a blob detector method. A pilot study was performed on 15 patients with 22 surgically confirmed strictures to study the effect of the CAD scheme on observer performance. The 77% sensitivity of an inexperienced radiologist assisted by CAD was comparable with the 81% sensitivity of an unaided expert radiologist (p=0.07). The use of CAD reduced the reading time to identify strictures significantly (pmuscles, or vessels, and they were easy to dismiss. The results indicate that CAD could provide radiologists with a rapid and accurate interpretation of strictures to improve workflow in an emergency setting.

  8. Software Infrastructure for Computer-aided Drug Discovery and Development, a Practical Example with Guidelines.

    Science.gov (United States)

    Moretti, Loris; Sartori, Luca

    2016-09-01

    In the field of Computer-Aided Drug Discovery and Development (CADDD) the proper software infrastructure is essential for everyday investigations. The creation of such an environment should be carefully planned and implemented with certain features in order to be productive and efficient. Here we describe a solution to integrate standard computational services into a functional unit that empowers modelling applications for drug discovery. This system allows users with various level of expertise to run in silico experiments automatically and without the burden of file formatting for different software, managing the actual computation, keeping track of the activities and graphical rendering of the structural outcomes. To showcase the potential of this approach, performances of five different docking programs on an Hiv-1 protease test set are presented.

  9. CASAD -- Computer-Aided Sonography of Abdominal Diseases - the concept of joint technique impact

    Directory of Open Access Journals (Sweden)

    T. Deserno

    2010-03-01

    Full Text Available Ultrasound image is the primary (input information for every ultrasonic examination. Since being used in ultrasound images analysis the both knowledge-base decision support and content-based image retrieval techniques have their own restrictions, the combination of these techniques looks promissory for covering the restrictions of one by advances of another. In this work we have focused on implementation of the proposed combination in the frame of CASAD (Computer-Aided Sonography of Abdominal Diseases system for supplying the ultrasound examiner with a diagnostic-assistant tool based on a data warehouse of standard referenced images. This warehouse serves: to manifest the diagnosis when the ecographist specifies the pathology and then looks through corresponding images to verify his opinion; to suggest a second opinion by automatic analysis of the annotation of relevant images that were assessed from the repository using content-based image retrieval.

  10. NO-FEAR Airlines: A Computer-aided Self-help Treatment for Flying Phobia.

    Science.gov (United States)

    Quero, Soledad; Campos, Daniel; Riera Del Amo, Antonio; Bretón-López, Juana; Tortella-Feliu, Miquel; Baños, Rosa Ma; Botella, Cristina

    2015-01-01

    In vivo exposure is the treatment of choice for specific phobias. However, this treatment is linked to a number of limitations in its implementation. Therefore, it is important to develop strategies for improving treatment adherence, acceptance, and dissemination of evidence-based treatments. Information and Communication Technologies, specifically, computerized programs boast advantages in treating flying phobia. NO-FEAR Airlines is a Computer-aided Self-help Treatment for this problem, which can be self-applied via Internet. NO-FEAR Airlines treatment protocol comprises three therapeutic components: psychoeducation, exposure and overlearning. Exposure is carried out through 6 scenarios that are composed by images and real sounds related to a flight in process. The aim of the present work is to describe NO-FEAR Airlines program.

  11. A Computer Aided Detection system for mammographic images implemented on a GRID infrastructure

    CERN Document Server

    Bottigli, U; Delogu, P; Fantacci, M E; Fauci, F; Forni, G; Golosio, B; Indovina, P L; Lauria, A; Magro, R; Masala, G L; Oliva, P R; Palmiero, R; Raso, G; Retico, A; Stefanini, A; Stumbo, S; Tangaro, S; Torres, E L

    2003-01-01

    The use of an automatic system for the analysis of mammographic images has proven to be very useful to radiologists in the investigation of breast cancer, especially in the framework of mammographic-screening programs. A breast neoplasia is often marked by the presence of microcalcification clusters and massive lesions in the mammogram: hence the need for tools able to recognize such lesions at an early stage. In the framework of the GPCALMA (GRID Platform for Computer Assisted Library for MAmmography) project, the co-working of italian physicists and radiologists built a large distributed database of digitized mammographic images (about 5500 images corresponding to 1650 patients) and developed a CAD (Computer Aided Detection) system, able to make an automatic search of massive lesions and microcalcification clusters. The CAD is implemented in the GPCALMA integrated station, which can be used also for digitization, as archive and to perform statistical analyses. Some GPCALMA integrated stations have already b...

  12. Computer-aided head film analysis: the University of California San Francisco method.

    Science.gov (United States)

    Baumrind, S; Miller, D M

    1980-07-01

    Computer technology is already assuming an important role in the management of orthodontic practices. The next 10 years are likely to see expansion in computer usage into the areas of diagnosis, treatment planning, and treatment-record keeping. In the areas of diagnosis and treatment planning, one of the first problems to be attacked will be the automation of head film analysis. The problems of constructing computer-aided systems for this purpose are considered herein in the light of the authors' 10 years of experience in developing a similar system for research purposes. The need for building in methods for automatic detection and correction of gross errors is discussed and the authors' method for doing so is presented. The construction of a rudimentary machine-readable data base for research and clinical purposes is described.

  13. Procafd: Computer Aided Tool for Synthesis-Design & Analysis of Chemical Process Flowsheets

    DEFF Research Database (Denmark)

    Kumar Tula, Anjan; Eden, Mario R.; Gani, Rafiqul

    2015-01-01

    In practice, chemical process synthesis-design involves identification of the processing route to reach a desired product from a specified set of raw materials, design of the operations involved in the processing route, the calculations of utility requirements, the calculations of waste...... are synthesized to form molecules in computer-aided molecular design (CAMD) techniques [4]. The main idea here was to apply the principle of group-contribution approach from chemical property estimation to the synthesis and design of chemical process flowsheets. That is, use process-groups representing different...... of mathematical programming techniques, (c) hybrid approach which combine two or more approaches. D’Anterroches [3] proposed a group contribution based hybrid approach to solve the synthesis-design problem where, chemical process flowsheets could be synthesized in the same way as atoms or groups of atoms...

  14. Computer-Aided Sperm Analysis (CASA) of sperm motility and hyperactivation.

    Science.gov (United States)

    Mortimer, David; Mortimer, Sharon T

    2013-01-01

    Progressive motility is a vital functional characteristic of ejaculated human spermatozoa that governs their ability to penetrate into, and migrate through, both cervical mucus and the oocyte vestments, and ultimately fertilize the oocyte. A detailed protocol, based on the most common computer-aided sperm analysis (CASA) system with phase contrast microscope optics, is provided for performing reliable assessments of sperm movement pattern characteristics ("kinematics") in semen. The protocol can also be used with washed sperm suspensions where, in addition, the percentages of motile and progressively motile spermatozoa can also be derived. Using CASA technology it is also possible to identify biologically, and hence clinically, important subpopulations of spermatozoa (e.g., those in semen with good mucus-penetrating characteristics, or those showing hyperactivation when incubated under capacitating conditions) by applying multi-parametric definitions on a cell-by-cell basis.

  15. An integrated computer aided system for integrated design of chemical processes

    DEFF Research Database (Denmark)

    Gani, Rafiqul; Hytoft, Glen; Jaksland, Cecilia

    1997-01-01

    In this paper, an Integrated Computer Aided System (ICAS), which is particularly suitable for solving problems related to integrated design of chemical processes; is presented. ICAS features include a model generator (generation of problem specific models including model simplification and model...... reduction), a simulator (use of problem specific simulation strategies for steady state and dynamic simulation), toolboxes (thermodynamic toolbox, synthesis toolbox, control toolbox, design toolbox and analysis toolbox), and an interface for problem defintion. Each toolbox solves aspecific set of problems...... and communicates with all other computational tools available in ICAS. A large range of thermodynamic models for estimation of the necessary thermo-physical properties, a large range of computational algorithms for determination of various types of phase diagrams, algorithms for process synthesis, design, control...

  16. A Systematic Computer-Aided Framework for Integrated Design and Control of Chemical Processes

    DEFF Research Database (Denmark)

    Mansouri, Seyed Soheil; Sales-Cruz, Mauricio; Huusom, Jakob Kjøbsted

    Chemical processes are conventionally designed through a sequential approach. In this sequential approach, first, a steady-state process design is obtained and then, control structure synthesis that, in most of the cases, is based on heuristics is performed. Therefore, process design and process......-defined operational conditions whereas controllability is considered to maintain desired operating points of the process at any kind of imposed disturbance under normal operating conditions. In this work, a systematic hierarchical computer-aided framework for integrated process design and control of chemical...... control and operation considerations have been studied independently. Furthermore, this sequential approach does not adequately answer this question, “How process design decisions influence process control and operation?”. In order to answer this question, it is necessary to consider process...

  17. Computer aided seismic and fire retrofitting analysis of existing high rise reinforced concrete buildings

    CERN Document Server

    Hussain, Raja Rizwan; Hasan, Saeed

    2016-01-01

    This book details the analysis and design of high rise buildings for gravity and seismic analysis. It provides the knowledge structural engineers need to retrofit existing structures in order to meet safety requirements and better prevent potential damage from such disasters as earthquakes and fires. Coverage includes actual case studies of existing buildings, reviews of current knowledge for damages and their mitigation, protective design technologies, and analytical and computational techniques. This monograph also provides an experimental investigation on the properties of fiber reinforced concrete that consists of natural fibres like coconut coir and also steel fibres that are used for comparison in both Normal Strength Concrete (NSC) and High Strength Concrete (HSC). In addition, the authors examine the use of various repair techniques for damaged high rise buildings. The book will help upcoming structural design engineers learn the computer aided analysis and design of real existing high rise buildings ...

  18. Using Computer Aided Assessment System to Assess College Students Writing Skill

    Directory of Open Access Journals (Sweden)

    Huihua He

    2011-03-01

    Full Text Available College students are facing challenges to present their ideas by writing a paper because they rely more on information from computer and web. The purpose of this paper is to present a novel computer aided assessment system, to assess college students’ writing ability. The CAAS system comprises of an expert team, a set of achievement standard for assessment, and software systems to conduct data analysis and store related information. It has been used by institute in U.S. It yields face validity and consistency reliability. Objective evaluation results will be provided by randomly-assigned multiple reviewers. CAAS can assist college students improve writing skills, can describ a brief picture and detailed information for both school administrators and policy makers as well.

  19. Computer Aided Teaching in Photogrammetry, Remote Sensing, and Geomatics - A Status Review

    Science.gov (United States)

    Vyas, A.; Koenig, G.

    2014-04-01

    Education and training play vital role in the utilization of the technology. Shared and coordinated knowledge that geospatial technology and GIS deliver provides a deeper understanding of our present and will also help to better understand our future development. But it is not enough to explain new technological developments during congresses or workshops; it is also necessary to promote these new ideas and to distribute the knowledge by applying new learning strategies. This paper will review the status of computer aided teaching advances during the last decade, with a particular emphasis on photogrammetry, remote sensing, and geomatics. Some best practise examples will be presented featuring prominently recent Massive Open Online Courses (MOOCs) related to our fields. The consideration of mainly free online learning resources will include a commentary on quality and perceived effectiveness.

  20. Towards Building a Computer Aided Education System for Special Students Using Wearable Sensor Technologies

    Directory of Open Access Journals (Sweden)

    Raja Majid Mehmood

    2017-02-01

    Full Text Available Human computer interaction is a growing field in terms of helping people in their daily life to improve their living. Especially, people with some disability may need an interface which is more appropriate and compatible with their needs. Our research is focused on similar kinds of problems, such as students with some mental disorder or mood disruption problems. To improve their learning process, an intelligent emotion recognition system is essential which has an ability to recognize the current emotional state of the brain. Nowadays, in special schools, instructors are commonly use some conventional methods for managing special students for educational purposes. In this paper, we proposed a novel computer aided method for instructors at special schools where they can teach special students with the support of our system using wearable technologies.