WorldWideScience

Sample records for computer aided integrated

  1. Integrated computer-aided design using minicomputers

    Science.gov (United States)

    Storaasli, O. O.

    1980-01-01

    Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM), a highly interactive software, has been implemented on minicomputers at the NASA Langley Research Center. CAD/CAM software integrates many formerly fragmented programs and procedures into one cohesive system; it also includes finite element modeling and analysis, and has been interfaced via a computer network to a relational data base management system and offline plotting devices on mainframe computers. The CAD/CAM software system requires interactive graphics terminals operating at a minimum of 4800 bits/sec transfer rate to a computer. The system is portable and introduces 'interactive graphics', which permits the creation and modification of models interactively. The CAD/CAM system has already produced designs for a large area space platform, a national transonic facility fan blade, and a laminar flow control wind tunnel model. Besides the design/drafting element analysis capability, CAD/CAM provides options to produce an automatic program tooling code to drive a numerically controlled (N/C) machine. Reductions in time for design, engineering, drawing, finite element modeling, and N/C machining will benefit productivity through reduced costs, fewer errors, and a wider range of configuration.

  2. An Integrated Computer-Aided Approach for Environmental Studies

    DEFF Research Database (Denmark)

    Gani, Rafiqul; Chen, Fei; Jaksland, Cecilia;

    1997-01-01

    A general framework for an integrated computer-aided approach to solve process design, control, and environmental problems simultaneously is presented. Physicochemical properties and their relationships to the molecular structure play an important role in the proposed integrated approach. The scope...... and applicability of the integrated approach is highlighted through examples involving estimation of properties and environmental pollution prevention. The importance of mixture effects on some environmentally important properties is also demonstrated....

  3. Integrated Science through Computer-aided Experiments

    Directory of Open Access Journals (Sweden)

    Stanislav HOLEC

    2004-10-01

    Full Text Available The paper outlines curriculum development activities that have been done in science education in the Slovak Republic as a result of an international collaboration within the frame of the Leonardo da Vinci II pilot project Computerised Laboratory in Science and Technology Teaching - ``ComLab-SciTech''. The created teaching and learning materials include integration of science curricula in two meanings: an integration of knowledge and methodology of physics, chemistry and biology, as well as an integration of various true and virtual computerised methods of experiments. The materials contain suggestions for student investigative activities, in which life science processes are studied with the use of laboratory models.

  4. Integrated computer-aided retinal photocoagulation system

    Science.gov (United States)

    Barrett, Steven F.; Wright, Cameron H. G.; Oberg, Erik D.; Rockwell, Benjamin A.; Cain, Clarence P.; Jerath, Maya R.; Rylander, Henry G., III; Welch, Ashley J.

    1996-05-01

    Successful retinal tracking subsystem testing results in vivo on rhesus monkeys using an argon continuous wave laser and an ultra-short pulse laser are presented. Progress on developing an integrated robotic retinal laser surgery system is also presented. Several interesting areas of study have developed: (1) 'doughnut' shaped lesions that occur under certain combinations of laser power, spot size, and irradiation time complicating measurements of central lesion reflectance, (2) the optimal retinal field of view to achieve simultaneous tracking and lesion parameter control, and (3) a fully digital versus a hybrid analog/digital tracker using confocal reflectometry integrated system implementation. These areas are investigated in detail in this paper. The hybrid system warrants a separate presentation and appears in another paper at this conference.

  5. Computer Aided Engineering of Semiconductor Integrated Circuits

    Science.gov (United States)

    1976-04-01

    transistor opera tion; (4) theoretical invest! jations of carrifr mobli *!;y *"« inversion layer of an MOSFET; (5) mathematical investigations for high...satisfactory greLnt «Lh experiment. In time, the rapid groWth of se.r- oonduotor integrated circuit (IC, technology created ^ ^ °n" £or which this theory was...and Technology of Semiconductor Devices, John Wiley and Sons, Inc., N.Y. (1967). [2] S. K. Ghandi, The Theory and Practice of

  6. Conceptual framework for the integration of computer-aided design and computer-aided process planning

    Energy Technology Data Exchange (ETDEWEB)

    Li, R.K.

    1986-01-01

    This research presents a conceptual framework for the integration of Computer-Aided Design (CAD) and Computer-Aided Process Planning (CAPP). The conceptual framework resides in an environmental of N CAD systems and M CAPP systems. It consists of three major modules: a generic-part definition data structure, a preprocessor, and a postprocessor. The generic-part definition data structure was developed to serve as a neutral-part definition data representation between CAD and CAPP systems. With this structure, the number of interfacing systems can be reduced to 1 + M systems. The preprocessor, a part feature recognition system, is designed to extract part definition data from an IGES file, evaluates that data, allows inclusion of unsupported data, and finally puts the data into the data structure. The postprocessor was written to convert the data from the data structure to the part input format of a selected CAPP system. A prototype systems that uses IBM's CAD package (CADAM), IGES and United Technologies Research Center's CAPP package (CMPP) was developed to test and prove the concept of this research. The input is a CADAM graphic design file and the outputs are a summary of operations and a tolerance control chart which are ready to be used in the production shops.

  7. An integrated computer aided system for integrated design of chemical processes

    DEFF Research Database (Denmark)

    Gani, Rafiqul; Hytoft, Glen; Jaksland, Cecilia

    1997-01-01

    In this paper, an Integrated Computer Aided System (ICAS), which is particularly suitable for solving problems related to integrated design of chemical processes; is presented. ICAS features include a model generator (generation of problem specific models including model simplification and model...... reduction), a simulator (use of problem specific simulation strategies for steady state and dynamic simulation), toolboxes (thermodynamic toolbox, synthesis toolbox, control toolbox, design toolbox and analysis toolbox), and an interface for problem defintion. Each toolbox solves aspecific set of problems...... and communicates with all other computational tools available in ICAS. A large range of thermodynamic models for estimation of the necessary thermo-physical properties, a large range of computational algorithms for determination of various types of phase diagrams, algorithms for process synthesis, design, control...

  8. Decision trees and integrated features for computer aided mammographic screening

    Energy Technology Data Exchange (ETDEWEB)

    Kegelmeyer, W.P. Jr.; Groshong, B.; Allmen, M.; Woods, K.

    1997-02-01

    Breast cancer is a serious problem, which in the United States causes 43,000 deaths a year, eventually striking 1 in 9 women. Early detection is the only effective countermeasure, and mass mammography screening is the only reliable means for early detection. Mass screening has many shortcomings which could be addressed by a computer-aided mammographic screening system. Accordingly, we have applied the pattern recognition methods developed in earlier investigations of speculated lesions in mammograms to the detection of microcalcifications and circumscribed masses, generating new, more rigorous and uniform methods for the detection of both those signs. We have also improved the pattern recognition methods themselves, through the development of a new approach to combinations of multiple classifiers.

  9. Integrating aerodynamic surface modeling for computational fluid dynamics with computer aided structural analysis, design, and manufacturing

    Science.gov (United States)

    Thorp, Scott A.

    1992-01-01

    This presentation will discuss the development of a NASA Geometry Exchange Specification for transferring aerodynamic surface geometry between LeRC systems and grid generation software used for computational fluid dynamics research. The proposed specification is based on a subset of the Initial Graphics Exchange Specification (IGES). The presentation will include discussion of how the NASA-IGES standard will accommodate improved computer aided design inspection methods and reverse engineering techniques currently being developed. The presentation is in viewgraph format.

  10. Computer aided production engineering

    Energy Technology Data Exchange (ETDEWEB)

    1986-01-01

    This book presents the following contents: CIM in avionics; computer analysis of product designs for robot assembly; a simulation decision mould for manpower forecast and its application; development of flexible manufacturing system; advances in microcomputer applications in CAD/CAM; an automated interface between CAD and process planning; CAM and computer vision; low friction pneumatic actuators for accurate robot control; robot assembly of printed circuit boards; information systems design for computer integrated manufacture; and a CAD engineering language to aid manufacture.

  11. A Computer-Based, Interactive Videodisc Job Aid and Expert System for Electron Beam Lithography Integration and Diagnostic Procedures.

    Science.gov (United States)

    Stevenson, Kimberly

    This master's thesis describes the development of an expert system and interactive videodisc computer-based instructional job aid used for assisting in the integration of electron beam lithography devices. Comparable to all comprehensive training, expert system and job aid development require a criterion-referenced systems approach treatment to…

  12. Computer aided process planning system based on workflow technology and integrated bill of material tree

    Institute of Scientific and Technical Information of China (English)

    LU Chun-guang; MENG Li-li

    2006-01-01

    It is extremely important for procedure of process design and management of process data for product life cycle in Computer Aided Process Planning (CAPP) system,but there are many shortcomings with traditional CAPP system in these respects.To solve these questions,application of workflow technology in CAPP system based on web-integrated Bill of Material (BOM) tree is discussed,and a concept of integrated BOM tree was brought forward.Taking integrated BOM as the thread,CAPP systematic technological process is analyzed.The function,system architecture,and implementation mechanism of CAPP system based on Browser/Server and Customer/Server model are expatiated.Based on it,the key technologies of workflow management device were analyzed.Eventually,the implementation mechanism of integrated BOM tree was analyzed from viewpoints of material information encoding,organization node design of integrated BOM tree,transformation from Engineering BOM (EBOM)to Process BOM (PBOM),and the programming implementation technology.

  13. Facilitating Integration of Electron Beam Lithography Devices with Interactive Videodisc, Computer-Based Simulation and Job Aids.

    Science.gov (United States)

    Von Der Linn, Robert Christopher

    A needs assessment of the Grumman E-Beam Systems Group identified the requirement for additional skill mastery for the engineers who assemble, integrate, and maintain devices used to manufacture integrated circuits. Further analysis of the tasks involved led to the decision to develop interactive videodisc, computer-based job aids to enable…

  14. A Systematic Computer-Aided Framework for Integrated Design and Control of Chemical Processes

    DEFF Research Database (Denmark)

    Mansouri, Seyed Soheil; Sales-Cruz, Mauricio; Huusom, Jakob Kjøbsted

    Chemical processes are conventionally designed through a sequential approach. In this sequential approach, first, a steady-state process design is obtained and then, control structure synthesis that, in most of the cases, is based on heuristics is performed. Therefore, process design and process......-defined operational conditions whereas controllability is considered to maintain desired operating points of the process at any kind of imposed disturbance under normal operating conditions. In this work, a systematic hierarchical computer-aided framework for integrated process design and control of chemical...... control and operation considerations have been studied independently. Furthermore, this sequential approach does not adequately answer this question, “How process design decisions influence process control and operation?”. In order to answer this question, it is necessary to consider process...

  15. Computer aided control engineering

    DEFF Research Database (Denmark)

    Szymkat, Maciej; Ravn, Ole

    1997-01-01

    levels.The major conclusions of the paper are related with identifying the factors affecting the software tool integration in a way needed to facilitate design "inter-phase" communication. These are: standard application interfaces, dynamic data exchange mechanisms, code generation techniques and general......Current developments in the field of Computer Aided Control Engineering (CACE) have a visible impact on the design methodologies and the structure of the software tools supporting them. Today control engineers has at their disposal libraries, packages or programming environments that may...

  16. Role of computer aided detection (CAD) integration: case study with meniscal and articular cartilage CAD applications

    Science.gov (United States)

    Safdar, Nabile; Ramakrishna, Bharath; Saiprasad, Ganesh; Siddiqui, Khan; Siegel, Eliot

    2008-03-01

    Knee-related injuries involving the meniscal or articular cartilage are common and require accurate diagnosis and surgical intervention when appropriate. With proper techniques and experience, confidence in detection of meniscal tears and articular cartilage abnormalities can be quite high. However, for radiologists without musculoskeletal training, diagnosis of such abnormalities can be challenging. In this paper, the potential of improving diagnosis through integration of computer-aided detection (CAD) algorithms for automatic detection of meniscal tears and articular cartilage injuries of the knees is studied. An integrated approach in which the results of algorithms evaluating either meniscal tears or articular cartilage injuries provide feedback to each other is believed to improve the diagnostic accuracy of the individual CAD algorithms due to the known association between abnormalities in these distinct anatomic structures. The correlation between meniscal tears and articular cartilage injuries is exploited to improve the final diagnostic results of the individual algorithms. Preliminary results from the integrated application are encouraging and more comprehensive tests are being planned.

  17. An integrated computer-aided system for generation and evaluation of sustainable process alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, Niels; Coll, Nuria; Gani, Rafiqul [CAPEC, Department of Chemical Engineering, Technical University of Denmark, 2800, Lyngby (Denmark)

    2003-10-01

    This paper presents an integrated system for generation of sustainable process alternatives with respect to new process design as well as retrofit design. The generated process alternatives are evaluated through sustainability metrics, environmental impact factors as well as inherent safety factors. The process alternatives for new process design as well as retrofit design are generated through a systematic method that is simple yet effective and is based on a recently developed path flow analysis approach. According to this approach, a set of indicators are calculated in order to pinpoint unnecessary energy and material waste costs and to identify potential design (retrofit) targets that may improve the process design (in terms of operation and cost) simultaneously with the sustainability metrics, environmental impact factors and the inherent safety factors. Only steady state design data and a database with properties of compounds, including, environmental impact factor related data and safety factor related data are needed. The integrated computer-aided system generates the necessary data if actual plant or experimental data are not available. The application of the integrated system is highlighted through a number of examples including the well-known HDA process. (orig.)

  18. Integrated Computer Aided Planning and Manufacture of Advanced Technology Jet Engines

    Directory of Open Access Journals (Sweden)

    B. K. Subhas

    1987-10-01

    Full Text Available This paper highlights an attempt at evolving a computer aided manufacturing system on a personal computer. A case study of an advanced technology jet engine component is included to illustrate various outputs from the system. The proposed system could be an alternate solution to sophisticated and expensive CAD/CAM workstations.

  19. Associating Drugs, Targets and Clinical Outcomes into an Integrated Network Affords a New Platform for Computer-Aided Drug Repurposing

    DEFF Research Database (Denmark)

    Oprea, Tudor; Nielsen, Sonny Kim; Ursu, Oleg

    2011-01-01

    benefit from an integrated, semantic-web compliant computer-aided drug repurposing (CADR) effort, one that would enable deep data mining of associations between approved drugs (D), targets (T), clinical outcomes (CO) and SE. We report preliminary results from text mining and multivariate statistics, based...

  20. Computer-Aided Modeling Framework

    DEFF Research Database (Denmark)

    Fedorova, Marina; Sin, Gürkan; Gani, Rafiqul

    development and application. The proposed work is a part of the project for development of methods and tools that will allow systematic generation, analysis and solution of models for various objectives. It will use the computer-aided modeling framework that is based on a modeling methodology, which combines....... In this contribution, the concept of template-based modeling is presented and application is highlighted for the specific case of catalytic membrane fixed bed models. The modeling template is integrated in a generic computer-aided modeling framework. Furthermore, modeling templates enable the idea of model reuse...... are generated through the template in ICAS-MoT and translated into a model object. Once in ICAS-MoT, the model is numerical analyzed, solved and identified. A computer-aided modeling framework integrating systematic model derivation and development tools has been developed. It includes features for model...

  1. Computer Aided Lecturing.

    Science.gov (United States)

    Van Meter, Donald E.

    1994-01-01

    Surveyed students taking a natural resource conservation course to determine the effects of computer software that provides tools for creating and managing visual presentations to students. Results indicated that 94% of the respondents believed computer-aided lectures helped them and recommended their continued use; note taking was more effective,…

  2. An Analysis of Computer Aided Design (CAD) Packages Used at MSFC for the Recent Initiative to Integrate Engineering Activities

    Science.gov (United States)

    Smith, Leigh M.; Parker, Nelson C. (Technical Monitor)

    2002-01-01

    This paper analyzes the use of Computer Aided Design (CAD) packages at NASA's Marshall Space Flight Center (MSFC). It examines the effectiveness of recent efforts to standardize CAD practices across MSFC engineering activities. An assessment of the roles played by management, designers, analysts, and manufacturers in this initiative will be explored. Finally, solutions are presented for better integration of CAD across MSFC in the future.

  3. The Computer Aided Integrated Design and Analysis of Oil Tank in Vehicle

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    This paper creates 3D solid model and assembly of U RJ 92-6 oil tank and analyses its strength by integrated CAD/CAE/CAM software I-D EAS. Through integrated simulation in computer, design efficiency and quality of oil tank is greatly improved. Adopting integrated CAD/CAE/CAM software to carry out integrated research to equ ipment and products, we will be able to take overall analysis in aspects of 3-D solid modeling, pre-assembly and strength, etc., to realize non-paper designi ng and parallel designing...

  4. Computer aided control engineering

    DEFF Research Database (Denmark)

    Szymkat, Maciej; Ravn, Ole

    1997-01-01

    Current developments in the field of Computer Aided Control Engineering (CACE) have a visible impact on the design methodologies and the structure of the software tools supporting them. Today control engineers has at their disposal libraries, packages or programming environments that may be speci......Current developments in the field of Computer Aided Control Engineering (CACE) have a visible impact on the design methodologies and the structure of the software tools supporting them. Today control engineers has at their disposal libraries, packages or programming environments that may...

  5. An Architecture of Computer Aided Process Planning System Integrated with Scheduling Using Decision Support System

    Institute of Scientific and Technical Information of China (English)

    Manish; Kumar; Sunil; Rajotia

    2002-01-01

    Process planning and scheduling are two major plann in g and control activities that consume significant part of the lead-time, theref ore all attempts are being made to reduce lead-time by automating them. Compute r Aided Process Planning (CAPP) is a step in this direction. Most of the existin g CAPP systems do not consider scheduling while generating a process plan. Sched uling is done separately after the process plan has been generated and therefore , it is possible that a process plan so generated is e...

  6. Computer aided product design

    DEFF Research Database (Denmark)

    Constantinou, Leonidas; Bagherpour, Khosrow; Gani, Rafiqul

    1996-01-01

    A general methodology for Computer Aided Product Design (CAPD) with specified property constraints which is capable of solving a large range of problems is presented. The methodology employs the group contribution approach, generates acyclic, cyclic and aromatic compounds of various degrees......-liquid equilibria (LLE), solid-liquid equilibria (SLE) and gas solubility. Finally, a computer program based on the extended methodology has been developed and the results from five case studies highlighting various features of the methodology are presented....

  7. Computer aided manipulator control

    Science.gov (United States)

    Bejczy, A. K.; Zawacki, R. L.

    1980-01-01

    This paper describes the hardware and software system of a dedicated mini- and microcomputer network developed at the JPL teleoperator project to aid the operator in real-time control of remote manipulators. The operator can be in series or in parallel with the control computer during operation. The purpose of the project is to develop, demonstrate and evaluate advanced supervisory control concepts and techniques for space applications. The paper concludes with a brief outline of future development plans and issues.

  8. Computer aided drug design

    Science.gov (United States)

    Jain, A.

    2017-08-01

    Computer based method can help in discovery of leads and can potentially eliminate chemical synthesis and screening of many irrelevant compounds, and in this way, it save time as well as cost. Molecular modeling systems are powerful tools for building, visualizing, analyzing and storing models of complex molecular structure that can help to interpretate structure activity relationship. The use of various techniques of molecular mechanics and dynamics and software in Computer aided drug design along with statistics analysis is powerful tool for the medicinal chemistry to synthesis therapeutic and effective drugs with minimum side effect.

  9. Computer-aided bone age assessment for ethnically diverse older children using integrated fuzzy logic system

    Science.gov (United States)

    Ma, Kevin; Moin, Paymann; Zhang, Aifeng; Liu, Brent

    2010-03-01

    Bone Age Assessment (BAA) of children is a clinical procedure frequently performed in pediatric radiology to evaluate the stage of skeletal maturation based on the left hand x-ray radiograph. The current BAA standard in the US is using the Greulich & Pyle (G&P) Hand Atlas, which was developed fifty years ago and was only based on Caucasian population from the Midwest US. To bring the BAA procedure up-to-date with today's population, a Digital Hand Atlas (DHA) consisting of 1400 hand images of normal children of different ethnicities, age, and gender. Based on the DHA and to solve inter- and intra-observer reading discrepancies, an automatic computer-aided bone age assessment system has been developed and tested in clinical environments. The algorithm utilizes features extracted from three regions of interests: phalanges, carpal, and radius. The features are aggregated into a fuzzy logic system, which outputs the calculated bone age. The previous BAA system only uses features from phalanges and carpal, thus BAA result for children over age of 15 is less accurate. In this project, the new radius features are incorporated into the overall BAA system. The bone age results, calculated from the new fuzzy logic system, are compared against radiologists' readings based on G&P atlas, and exhibits an improvement in reading accuracy for older children.

  10. Computer-Aided Modeling Framework

    DEFF Research Database (Denmark)

    Fedorova, Marina; Sin, Gürkan; Gani, Rafiqul

    with them. As the required models may be complex and require multiple time and/or length scales, their development and application for product-process design is not trivial. Therefore, a systematic modeling framework can contribute by significantly reducing the time and resources needed for model...... development and application. The proposed work is a part of the project for development of methods and tools that will allow systematic generation, analysis and solution of models for various objectives. It will use the computer-aided modeling framework that is based on a modeling methodology, which combines....... In this contribution, the concept of template-based modeling is presented and application is highlighted for the specific case of catalytic membrane fixed bed models. The modeling template is integrated in a generic computer-aided modeling framework. Furthermore, modeling templates enable the idea of model reuse...

  11. Integral system for computer aided design of power line transmission towers; Sistema integral para el diseno asistido por computadora de torres de transmision

    Energy Technology Data Exchange (ETDEWEB)

    Nagore, Gabriel [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1986-12-31

    The profitable use of the advantages offered by the computer aided design, through the integral system for the structural design of power transmission towers (SIDETT) will contribute to facilitate and improve the design of the structures that link the electric power generation centers with the consumers. [Espanol] El aprovechamiento de las ventajas que ofrece el diseno asistido por computadora, a traves del sistema integral para el diseno estructural de torres de transmision (SIDETT), contribuira a agilizar y mejorar el diseno de las estructuras que enlazan los centros de generacion de energia electrica con los consumidores.

  12. Computer aided surface representation

    Energy Technology Data Exchange (ETDEWEB)

    Barnhill, R E

    1987-11-01

    The aims of this research are the creation of new surface forms and the determination of geometric and physical properties of surfaces. The full sweep from constructive mathematics through the implementation of algorithms and the interactive computer graphics display of surfaces is utilized. Both three-dimensional and multi- dimensional surfaces are considered. Particular emphasis is given to the scientific computing solution of Department of Energy problems. The methods that we have developed and that we are proposing to develop allow applications such as: Producing smooth contour maps from measured data, such as weather maps. Modeling the heat distribution inside a furnace from sample measurements. Terrain modeling based on satellite pictures. The investigation of new surface forms includes the topics of triangular interpolants, multivariate interpolation, surfaces defined on surfaces and monotone and/or convex surfaces. The geometric and physical properties considered include contours, the intersection of surfaces, curvatures as a interrogation tool, and numerical integration.

  13. Designing Intelligent Computer Aided Instruction Systems with Integrated Knowledge Representation Schemes

    Science.gov (United States)

    1990-06-01

    for De- velopment of ICAI," Computers in Human Behavior , v. 3, 1987. Seidel, R. J., Park, 0.., and Perez, R. S., "Expertise of ICAI. Development...Require- ments," Computers in Human Behavior , v. 4, 1988. Sleeman, D., "Intellhent Tutoring Systems: A Review," School of Education and De- partment of

  14. Computer Aided Product Service Systems Design: Service CAD and Its integration with Life Cycle Simulation

    NARCIS (Netherlands)

    Komoto, H.

    2009-01-01

    Integration of product design into service design, or vice versa, is considered to bring more efficient and effective value addition. Besides EcoDesign tools and methods, a methodology to design such an integration of products and services from a systemic perspective, or product-service systems (PSS

  15. Computer Aided Product Service Systems Design: Service CAD and Its integration with Life Cycle Simulation

    NARCIS (Netherlands)

    Komoto, H.

    2009-01-01

    Integration of product design into service design, or vice versa, is considered to bring more efficient and effective value addition. Besides EcoDesign tools and methods, a methodology to design such an integration of products and services from a systemic perspective, or product-service systems

  16. Computer aided surface representation

    Energy Technology Data Exchange (ETDEWEB)

    Barnhill, R.E.

    1989-02-09

    The central research problem of this project is the effective representation and display of surfaces, interpolating to given information, in three or more dimensions. In a typical problem, we wish to create a surface from some discrete information. If this information is itself on another surface, the problem is to determine a surface defined on a surface,'' which is discussed below. Often, properties of an already constructed surface are desired: such geometry processing'' is described below. The Summary of Proposed Research from our original proposal describes the aims of this research project. This Summary and the Table of Contents from the original proposal are enclosed as an Appendix to this Progress Report. The broad sweep from constructive mathematics through algorithms and computer graphics displays is utilized in the research. The wide range of activity, directed in both theory and applications, makes this project unique. Last month in the first Ardent Titan delivered in the State of Arizona came to our group, funded by the DOE and Arizona State University. Although the Titan is a commercial product, its newness requires our close collaboration with Ardent to maximize results. During the past year, four faculty members and several graduate research assistants have worked on this DOE project. The gaining of new professionals is an important aspect of this project. A listing of the students and their topics is given in the Appendix. The most significant publication during the past year is the book, Curves and Surfaces for Computer Aided Geometric Design, by Dr. Gerald Farin. This 300 page volume helps fill a considerable gap in the subject and includes many new results on Bernstein-Bezier curves and surfaces.

  17. Integrated computer-aided design in automotive development development processes, geometric fundamentals, methods of CAD, knowledge-based engineering data management

    CERN Document Server

    Mario, Hirz; Gfrerrer, Anton; Lang, Johann

    2013-01-01

    The automotive industry faces constant pressure to reduce development costs and time while still increasing vehicle quality. To meet this challenge, engineers and researchers in both science and industry are developing effective strategies and flexible tools by enhancing and further integrating powerful, computer-aided design technology. This book provides a valuable overview of the development tools and methods of today and tomorrow. It is targeted not only towards professional project and design engineers, but also to students and to anyone who is interested in state-of-the-art computer-aided development. The book begins with an overview of automotive development processes and the principles of virtual product development. Focusing on computer-aided design, a comprehensive outline of the fundamentals of geometry representation provides a deeper insight into the mathematical techniques used to describe and model geometrical elements. The book then explores the link between the demands of integrated design pr...

  18. Associating Drugs, Targets and Clinical Outcomes into an Integrated Network Affords a New Platform for Computer-Aided Drug Repurposing.

    Science.gov (United States)

    Oprea, Tudor I; Nielsen, Sonny Kim; Ursu, Oleg; Yang, Jeremy J; Taboureau, Olivier; Mathias, Stephen L; Kouskoumvekaki, Lrene; Sklar, Larry A; Bologa, Cristian G

    2011-03-14

    Finding new uses for old drugs is a strategy embraced by the pharmaceutical industry, with increasing participation from the academic sector. Drug repurposing efforts focus on identifying novel modes of action, but not in a systematic manner. With intensive data mining and curation, we aim to apply bio- and cheminformatics tools using the DRUGS database, containing 3,837 unique small molecules annotated on 1,750 proteins. These are likely to serve as drug targets and antitargets (i.e., associated with side effects, SE). The academic community, the pharmaceutical sector and clinicians alike could benefit from an integrated, semantic-web compliant computer-aided drug repurposing (CADR) effort, one that would enable deep data mining of associations between approved drugs (D), targets (T), clinical outcomes (CO) and SE. We report preliminary results from text mining and multivariate statistics, based on 7,684 approved drug labels, ADL (Dailymed) via text mining. From the ADL corresponding to 988 unique drugs, the "adverse reactions" section was mapped onto 174 SE, then clustered via principal component analysis into a 5x5 self-organizing map that was integrated into a Cytoscape network of SE-D-T-CO. This type of data can be used to streamline drug repurposing and may result in novel insights that can lead to the identification of novel drug actions.

  19. Integrated Computer-Aided Manufacturing (ICAM) Architecture. Part 3. Volume 8. Technology Transfer.

    Science.gov (United States)

    1983-09-01

    Drvtd. . ; THE INFRl*,t.Ti j T’i’ MAI~ "WE BEL :1E’,E - .HA i * ARCHITECTURE P’,K’ l .... ’ J L.E % ANALYTICA ML ’-.q TEGTC 3USNS ZA<. * ~-- DAY OPERA...OF MANUFACTURING ENGINEER’S COMPUTF. AND AUTOMATED SYSTEMS ASSOCIATION (SME CASA ) REtrNTLY PUBLISHED THIS LOGO DEVELOPED BY ITS TECHNICAL COUNCIL AND...THAT, LIKE ICAM, SME CASA ALSO SEES INTEGRATED SYSTEMS ARCHITECTURE AND COMMON DATABASES AS THE CENTRAL FOCUS REQUIRED FOR FUTURE FACTORY INTEGRATION

  20. The Specification of an Integrated Computer-Aided Ship Design Process in an Academic Environment.

    Science.gov (United States)

    1984-06-01

    specifically used by SCADS include a DEC VAX-11/732 mainframe computer, DEC VT-100 text terminals, a Visual -55( qraphics/text terminal and an IMAGEN ...considered. Two graphical display terminals, the Tektronix 4100-Series and the Visual 500-Series, have been investigated. Both of these terminals meet the...PRESENTLY, THESE INCLUDE THE ’ VISUAL 550’ AND THE ’VT-IO0’. 64 7{ BALES USING A DATA FILE CONTAINING SHIP OFFSETS AND INTERACTIVE USER INPUT, THIS

  1. Integrated Computer-aided Framework for Sustainable Chemical Product Design and Evaluation

    DEFF Research Database (Denmark)

    Kalakul, Sawitree; Cignitti, Stefano; Zhang, Lei

    2016-01-01

    This work proposes an integrated model-based framework for chemical product design and evaluation based on which the software, VPPD-Lab (The Virtual Product-Process Design Laboratory) has been developed. The framework allows the following options: (1) design a product using design templates...... of the templates for three case studies: (i) the design of a refrigeration cycle, (ii) a mixture/blend design problem involving lubricant design and (iii) a tailor-made product design of jet-fuels (blended chemical products)....

  2. Computer Aided Mathematics

    DEFF Research Database (Denmark)

    Sinclair, Robert

    1998-01-01

    Course notes of a PhD course held in 1998. The central idea is to introduce students to computational mathematics using object oriented programming in C++.......Course notes of a PhD course held in 1998. The central idea is to introduce students to computational mathematics using object oriented programming in C++....

  3. Computer Aided Mathematics

    DEFF Research Database (Denmark)

    Sinclair, Robert

    1998-01-01

    Course notes of a PhD course held in 1998. The central idea is to introduce students to computational mathematics using object oriented programming in C++.......Course notes of a PhD course held in 1998. The central idea is to introduce students to computational mathematics using object oriented programming in C++....

  4. Computer aided surface representation

    Energy Technology Data Exchange (ETDEWEB)

    Barnhill, R.E.

    1990-02-19

    The central research problem of this project is the effective representation, computation, and display of surfaces interpolating to information in three or more dimensions. If the given information is located on another surface, then the problem is to construct a surface defined on a surface''. Sometimes properties of an already defined surface are desired, which is geometry processing''. Visualization of multivariate surfaces is possible by means of contouring higher dimensional surfaces. These problems and more are discussed below. The broad sweep from constructive mathematics through computational algorithms to computer graphics illustrations is utilized in this research. The breadth and depth of this research activity makes this research project unique.

  5. Computer Aided Design of Couplings

    OpenAIRE

    2011-01-01

    The research work explores computer-aided approach to the design of ten different couplings, viza viz: flange, solid rigid, hollow rigid, old ham/ cross-sliding, pin type flexible, sleeve, seller cone/compression, split muff, pulley flange and fairbian’s lap-box couplings. The approach utilizesstandard design equations of these couplings and link them together in computer software todetermine the design parameters of the couplings. The work reviews the procedural stepsinvolved in the design o...

  6. Computer Aided Design of Couplings

    OpenAIRE

    2011-01-01

    The research work explores computer-aided approach to the design of ten different couplings, viz a viz: flange, solid rigid, hollow rigid, old ham/ cross-sliding, pin type flexible, sleeve, seller cone/ compression, split muff, pulley flange and fairbian’s lap-box couplings. The approach utilizes standard design equations of these couplings and link them together in computer software to determine the design parameters of the couplings. The work reviews the procedural steps involved in the des...

  7. Computer-aided translation tools

    DEFF Research Database (Denmark)

    Christensen, Tina Paulsen; Schjoldager, Anne

    2016-01-01

    The paper reports on a questionnaire survey from 2013 of the uptake and use of computer-aided translation (CAT) tools by Danish translation service providers (TSPs) and discusses how these tools appear to have impacted on the Danish translation industry. According to our results, the uptake in De...

  8. Computer aided lexicography

    Science.gov (United States)

    Sklenář, Ivan; Kříž, Václav

    1990-11-01

    Programs with a natural-language user interface and text-processing programs require a vocabulary providing the mapping of the individual word form onto a lexeme, e.g. "says", "said", "saying"→"see". Examples of such programs are indexing programs for information retrieval, and spelling correctors for text-processing systems. The lexicographical task of such a computer vocabulary is especially difficult for Slavic languages, because their morphological structure is complex. An average Czech verb, for example, has 25 forms, and we have identified more than 100 paradigms for verbs. In order to support the creation of a Czech vocabulary, we have designed a system of programs for paradigm identification and derivation of words. The result of our effort is a vocabulary comprising 110 000 words and 1250 000 word forms. This vocabulary was used for the PASSAT system in the Czechoslovak Press Agency. This vocabulary may also be used in a spelling corrector. However, for such an application the vocabulary must be compressed into a compact form in order to shorten the access times. Compression is based on the paradigmatic structure of morphology which defines suffix sets for each word.

  9. Bridging the integration gap between imaging and information systems: a uniform data concept for content-based image retrieval in computer-aided diagnosis.

    Science.gov (United States)

    Welter, Petra; Riesmeier, Jörg; Fischer, Benedikt; Grouls, Christoph; Kuhl, Christiane; Deserno, Thomas M

    2011-01-01

    It is widely accepted that content-based image retrieval (CBIR) can be extremely useful for computer-aided diagnosis (CAD). However, CBIR has not been established in clinical practice yet. As a widely unattended gap of integration, a unified data concept for CBIR-based CAD results and reporting is lacking. Picture archiving and communication systems and the workflow of radiologists must be considered for successful data integration to be achieved. We suggest that CBIR systems applied to CAD should integrate their results in a picture archiving and communication systems environment such as Digital Imaging and Communications in Medicine (DICOM) structured reporting documents. A sample DICOM structured reporting template adaptable to CBIR and an appropriate integration scheme is presented. The proposed CBIR data concept may foster the promulgation of CBIR systems in clinical environments and, thereby, improve the diagnostic process.

  10. An Intelligent Computer-aided Training System (CAT) for Diagnosing Adult Illiterates: Integrating NASA Technology into Workplace Literacy

    Science.gov (United States)

    Yaden, David B., Jr.

    1991-01-01

    An important part of NASA's mission involves the secondary application of its technologies in the public and private sectors. One current application being developed is The Adult Literacy Evaluator, a simulation-based diagnostic tool designed to assess the operant literacy abilities of adults having difficulties in learning to read and write. Using Intelligent Computer-Aided Training (ICAT) system technology in addition to speech recognition, closed-captioned television (CCTV), live video and other state-of-the-art graphics and storage capabilities, this project attempts to overcome the negative effects of adult literacy assessment by allowing the client to interact with an intelligent computer system which simulates real-life literacy activities and materials and which measures literacy performance in the actual context of its use. The specific objectives of the project are as follows: (1) to develop a simulation-based diagnostic tool to assess adults' prior knowledge about reading and writing processes in actual contexts of application; (2) to provide a profile of readers' strengths and weaknesses; and (3) to suggest instructional strategies and materials which can be used as a beginning point for remediation. In the first and development phase of the project, descriptions of literacy events and environments are being written and functional literacy documents analyzed for their components. From these descriptions, scripts are being generated which define the interaction between the student, an on-screen guide and the simulated literacy environment.

  11. Computer-aided light sheet flow visualization

    Science.gov (United States)

    Stacy, Kathryn; Severance, Kurt; Childers, Brooks A.

    1993-01-01

    A computer-aided flow visualization process has been developed to analyze video images acquired from rotating and translating light sheet visualization systems. The computer process integrates a mathematical model for image reconstruction, advanced computer graphics concepts, and digital image processing to provide a quantitative and visual analysis capability. The image reconstruction model, based on photogrammetry, uses knowledge of the camera and light sheet locations and orientations to project two-dimensional light sheet video images into three-dimensional space. A sophisticated computer visualization package, commonly used to analyze computational fluid dynamics (CFD) data sets, was chosen to interactively display the reconstructed light sheet images, along with the numerical surface geometry for the model or aircraft under study. A description is provided of the photogrammetric reconstruction technique, and the image processing and computer graphics techniques and equipment. Results of the computer aided process applied to both a wind tunnel translating light sheet experiment and an in-flight rotating light sheet experiment are presented. The capability to compare reconstructed experimental light sheet images and CFD solutions in the same graphics environment is also demonstrated.

  12. Computer Aided in situ Cognitive Behavioral Therapy

    DEFF Research Database (Denmark)

    Chongtay, Rocio A.; Hansen, John Paulin; Decker, Lone

    2006-01-01

    This article describes the development of a system intended to aid the treatment of certain phobic conditions by the use of computer telephony integration (CTI).A phobia is an irrational fear to some situations or things and interferes with the functioning of the individual that suffers from it....... One of the most common and successfully used treatments for phobic conditions has been Cognitive Behavioral Therapy (CBT), which helps people learn to detect thinking patterns that trigger the irrational fear and to replace them with more realistic ideas. The health and financial impacts in society...... present a strong motivation to find ways to help in the treatment of these disorders. Access to treatment can be limited by the availability of trained mental health professionals, and more patients could get help if the therapist could delegate part of the treatment to computer-aided CBT. The system...

  13. Computer-aided decision making.

    Science.gov (United States)

    Keith M. Reynolds; Daniel L. Schmoldt

    2006-01-01

    Several major classes of software technologies have been used in decisionmaking for forest management applications over the past few decades. These computer-based technologies include mathematical programming, expert systems, network models, multi-criteria decisionmaking, and integrated systems. Each technology possesses unique advantages and disadvantages, and has...

  14. Computer-aided system design

    Science.gov (United States)

    Walker, Carrie K.

    1991-01-01

    A technique has been developed for combining features of a systems architecture design and assessment tool and a software development tool. This technique reduces simulation development time and expands simulation detail. The Architecture Design and Assessment System (ADAS), developed at the Research Triangle Institute, is a set of computer-assisted engineering tools for the design and analysis of computer systems. The ADAS system is based on directed graph concepts and supports the synthesis and analysis of software algorithms mapped to candidate hardware implementations. Greater simulation detail is provided by the ADAS functional simulator. With the functional simulator, programs written in either Ada or C can be used to provide a detailed description of graph nodes. A Computer-Aided Software Engineering tool developed at the Charles Stark Draper Laboratory (CSDL CASE) automatically generates Ada or C code from engineering block diagram specifications designed with an interactive graphical interface. A technique to use the tools together has been developed, which further automates the design process.

  15. Computer Aided Battery Engineering Consortium

    Energy Technology Data Exchange (ETDEWEB)

    Pesaran, Ahmad

    2016-06-07

    A multi-national lab collaborative team was assembled that includes experts from academia and industry to enhance recently developed Computer-Aided Battery Engineering for Electric Drive Vehicles (CAEBAT)-II battery crush modeling tools and to develop microstructure models for electrode design - both computationally efficient. Task 1. The new Multi-Scale Multi-Domain model framework (GH-MSMD) provides 100x to 1,000x computation speed-up in battery electrochemical/thermal simulation while retaining modularity of particles and electrode-, cell-, and pack-level domains. The increased speed enables direct use of the full model in parameter identification. Task 2. Mechanical-electrochemical-thermal (MECT) models for mechanical abuse simulation were simultaneously coupled, enabling simultaneous modeling of electrochemical reactions during the short circuit, when necessary. The interactions between mechanical failure and battery cell performance were studied, and the flexibility of the model for various batteries structures and loading conditions was improved. Model validation is ongoing to compare with test data from Sandia National Laboratories. The ABDT tool was established in ANSYS. Task 3. Microstructural modeling was conducted to enhance next-generation electrode designs. This 3- year project will validate models for a variety of electrodes, complementing Advanced Battery Research programs. Prototype tools have been developed for electrochemical simulation and geometric reconstruction.

  16. Computer Aided in situ Cognitive Behavioral Therapy

    DEFF Research Database (Denmark)

    Chongtay, Rocio A.; Hansen, John Paulin; Decker, Lone

    2006-01-01

    This article describes the development of a system intended to aid the treatment of certain phobic conditions by the use of computer telephony integration (CTI).A phobia is an irrational fear to some situations or things and interferes with the functioning of the individual that suffers from it....... One of the most common and successfully used treatments for phobic conditions has been Cognitive Behavioral Therapy (CBT), which helps people learn to detect thinking patterns that trigger the irrational fear and to replace them with more realistic ideas. The health and financial impacts in society...

  17. Integrating computer-aided modeling and micro-simulation in multi-criteria evaluation of service infrastructure assignment approaches

    Directory of Open Access Journals (Sweden)

    Alfonso Duran

    2013-07-01

    Full Text Available Purpose: This paper proposes an integrated computer-supported multi-staged approach to the flexible design and multicriteria evaluation of service infrastructure assignment processes/ algorithms. Design/methodology/approach: It involves particularizing a metamodel encompassing the main generic components and relationships into process models and process instances, by incorporating structural data from the real-life system. Existing data on the target user population is fed into a micro-modeling system to generate a matching population of individual “virtual” users, each with its own set of trait values. The micro-simulation of their interaction with the assignment process of both the incumbent and the competitors generates a rich multi-dimensional output, encompassing both “revealed” and non-observable data. This enables a comprehensive multi-criteria evaluation of the foreseeable performance of the designed process/ algorithm, and therefore its iterative improvement. Findings: The research project developed a set of methodologies and associated supporting tools encompassing the modeling, micro-simulation and performance assessment of service infrastructure assignment processes. Originality/value: The proposed approach facilitates, in a multicriteria environment, the flexible modeling/design of situation-specific assignment processes/algorithms and their performance assessment when facing their case-specific user population.

  18. Increasing the Practical Impact of Formal Methods for Computer-Aided Software Development: Software Slicing, Merging and Integration

    Science.gov (United States)

    1993-10-15

    and M. Felleisen . Ile semantics of program dependence. In Proceedings of the SIGPLAN 󈨝 Conference on Programming Languages Design and Implementation...a big problem, the process does not have to be "creative". In particular, it can be aided by knowledge of common patterns of program design , such as...applications like program restructuring, studying this approach may benefit the designers of related kinds of tools. Automated assistance of program

  19. Computer-aided design and computer science technology

    Science.gov (United States)

    Fulton, R. E.; Voigt, S. J.

    1976-01-01

    A description is presented of computer-aided design requirements and the resulting computer science advances needed to support aerospace design. The aerospace design environment is examined, taking into account problems of data handling and aspects of computer hardware and software. The interactive terminal is normally the primary interface between the computer system and the engineering designer. Attention is given to user aids, interactive design, interactive computations, the characteristics of design information, data management requirements, hardware advancements, and computer science developments.

  20. Quality Indexing with Computer-Aided Lexicography.

    Science.gov (United States)

    Buchan, R. L.

    1992-01-01

    Discussion of computer-aided indexing activity focuses on examples from projects at the National Aeronautics and Space Administration (NASA). Standardization and quality in providing subject access to databases are considered; and computer-aided lexicography, including thesaurus construction, access vocabulary, definitions preparation,…

  1. Computer Aided Design in Engineering Education.

    Science.gov (United States)

    Gobin, R.

    1986-01-01

    Discusses the use of Computer Aided Design (CAD) and Computer Aided Manufacturing (CAM) systems in an undergraduate engineering education program. Provides a rationale for CAD/CAM use in the already existing engineering program. Describes the methods used in choosing the systems, some initial results, and warnings for first-time users. (TW)

  2. User-Centered Computer Aided Language Learning

    Science.gov (United States)

    Zaphiris, Panayiotis, Ed.; Zacharia, Giorgos, Ed.

    2006-01-01

    In the field of computer aided language learning (CALL), there is a need for emphasizing the importance of the user. "User-Centered Computer Aided Language Learning" presents methodologies, strategies, and design approaches for building interfaces for a user-centered CALL environment, creating a deeper understanding of the opportunities and…

  3. Computer Aided Design Modeling for Heterogeneous Objects

    CERN Document Server

    Gupta, Vikas; Tandon, Puneet

    2010-01-01

    Heterogeneous object design is an active research area in recent years. The conventional CAD modeling approaches only provide geometry and topology of the object, but do not contain any information with regard to the materials of the object and so can not be used for the fabrication of heterogeneous objects (HO) through rapid prototyping. Current research focuses on computer-aided design issues in heterogeneous object design. A new CAD modeling approach is proposed to integrate the material information into geometric regions thus model the material distributions in the heterogeneous object. The gradient references are used to represent the complex geometry heterogeneous objects which have simultaneous geometry intricacies and accurate material distributions. The gradient references helps in flexible manipulability and control to heterogeneous objects, which guarantees the local control over gradient regions of developed heterogeneous objects. A systematic approach on data flow, processing, computer visualizat...

  4. Computer-Aided Medical Diagnosis. Literature Review

    Science.gov (United States)

    1978-12-15

    BOUCKAERT, A., Computer-aided diagnosis of goitres in a cancer department, Int. J. Bio-’Med. Comput., 3 (1972) p. 3. BOYLE, J. A., GREIG, W. R., FRANKLIN, D...toxic goitre , Q. J. Med., 35 (1966) p. 565. Bricetti, A. B. and Bleich, H. L., A computer program that evaluates patients with hypercalcemia, J

  5. Computer Aided Control System Design (CACSD)

    Science.gov (United States)

    Stoner, Frank T.

    1993-01-01

    The design of modern aerospace systems relies on the efficient utilization of computational resources and the availability of computational tools to provide accurate system modeling. This research focuses on the development of a computer aided control system design application which provides a full range of stability analysis and control design capabilities for aerospace vehicles.

  6. ToxEvaluator: an integrated computational platform to aid the interpretation of toxicology study-related findings.

    Science.gov (United States)

    Pelletier, D; Wiegers, T C; Enayetallah, A; Kibbey, C; Gosink, M; Koza-Taylor, P; Mattingly, C J; Lawton, M

    2016-01-01

    Attempts are frequently made to investigate adverse findings from preclinical toxicology studies in order to better understand underlying toxicity mechanisms. These efforts often begin with limited information, including a description of the adverse finding, knowledge of the structure of the chemical associated with its cause and the intended pharmacological target. ToxEvaluator was developed jointly by Pfizer and the Comparative Toxicogenomics Database (http://ctdbase.org) team at North Carolina State University as an in silico platform to facilitate interpretation of toxicity findings in light of prior knowledge. Through the integration of a diverse set of in silico tools that leverage a number of public and proprietary databases, ToxEvaluator streamlines the process of aggregating and interrogating diverse sources of information. The user enters compound and target identifiers, and selects adverse event descriptors from a safety lexicon and mapped MeSH disease terms. ToxEvaluator provides a summary report with multiple distinct areas organized according to what target or structural aspects have been linked to the adverse finding, including primary pharmacology, structurally similar proprietary compounds, structurally similar public domain compounds, predicted secondary (i.e. off-target) pharmacology and known secondary pharmacology. Similar proprietary compounds and their associated in vivo toxicity findings are reported, along with a link to relevant supporting documents. For similar public domain compounds and interacting targets, ToxEvaluator integrates relationships curated in Comparative Toxicogenomics Database, returning all direct and inferred linkages between them. As an example of its utility, we demonstrate how ToxEvaluator rapidly identified direct (primary pharmacology) and indirect (secondary pharmacology) linkages between cerivastatin and myopathy.

  7. Computer aided design of microcircuits. Citations from the NTIS data base

    Science.gov (United States)

    Reed, W. E.

    1980-09-01

    Government sponsored research covering the computer aided design, modeling, layout, and packaging of integrated and other microelectronic circuits are cited. Computer programs and the use of computer graphics are included.

  8. Quality indexing with computer-aided lexicography

    Science.gov (United States)

    Buchan, Ronald L.

    1992-01-01

    Indexing with computers is a far cry from indexing with the first indexing tool, the manual card sorter. With the aid of computer-aided lexicography, both indexing and indexing tools can provide standardization, consistency, and accuracy, resulting in greater quality control than ever before. A brief survey of computer activity in indexing is presented with detailed illustrations from NASA activity. Applications from techniques mentioned, such as Retrospective Indexing (RI), can be made to many indexing systems. In addition to improving the quality of indexing with computers, the improved efficiency with which certain tasks can be done is demonstrated.

  9. Integration of 3D anatomical data obtained by CT imaging and 3D optical scanning for computer aided implant surgery

    Directory of Open Access Journals (Sweden)

    Paoli Alessandro

    2011-02-01

    Full Text Available Abstract Background A precise placement of dental implants is a crucial step to optimize both prosthetic aspects and functional constraints. In this context, the use of virtual guiding systems has been recognized as a fundamental tool to control the ideal implant position. In particular, complex periodontal surgeries can be performed using preoperative planning based on CT data. The critical point of the procedure relies on the lack of accuracy in transferring CT planning information to surgical field through custom-made stereo-lithographic surgical guides. Methods In this work, a novel methodology is proposed for monitoring loss of accuracy in transferring CT dental information into periodontal surgical field. The methodology is based on integrating 3D data of anatomical (impression and cast and preoperative (radiographic template models, obtained by both CT and optical scanning processes. Results A clinical case, relative to a fully edentulous jaw patient, has been used as test case to assess the accuracy of the various steps concurring in manufacturing surgical guides. In particular, a surgical guide has been designed to place implants in the bone structure of the patient. The analysis of the results has allowed the clinician to monitor all the errors, which have been occurring step by step manufacturing the physical templates. Conclusions The use of an optical scanner, which has a higher resolution and accuracy than CT scanning, has demonstrated to be a valid support to control the precision of the various physical models adopted and to point out possible error sources. A case study regarding a fully edentulous patient has confirmed the feasibility of the proposed methodology.

  10. Integrated Computer System of Management in Logistics

    Science.gov (United States)

    Chwesiuk, Krzysztof

    2011-06-01

    This paper aims at presenting a concept of an integrated computer system of management in logistics, particularly in supply and distribution chains. Consequently, the paper includes the basic idea of the concept of computer-based management in logistics and components of the system, such as CAM and CIM systems in production processes, and management systems for storage, materials flow, and for managing transport, forwarding and logistics companies. The platform which integrates computer-aided management systems is that of electronic data interchange.

  11. De novo computer-aided design of novel antiviral agents.

    Science.gov (United States)

    Massarotti, Alberto; Coluccia, Antonio; Sorba, Giovanni; Silvestri, Romano; Brancale, Andrea

    2012-01-01

    Computer-aided drug design techniques have become an integral part of the drug discovery process. In particular, de novo methodologies can be useful to identify putative ligands for a specific target relying only on the structural information of the target itself. Here we discuss the basic de novo approaches available and their application in antiviral drug design.:

  12. Computer aided materials design; Keisanki zairyo sekkei

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    The questionnaire survey on the computer aided materials design (CAMD), and the survey of current domestic and overseas software concerned were carried out to clarify developmental issues. The current elementary technology of CAMD was also surveyed to study its several problems caused with a progress of material design technology due to drastic diffusion of CAMD. This project aims at establishment of a new demanded software, computer chemistry, focusing attention on functional materials such as catalyst, polymer and non-linear electronic materials. Microscopic simulation technology was mainly surveyed in fiscal 1996. Although some fruitful results have been obtained in the fields of medical and agricultural chemicals, organic compounds, proteins, catalysts and electronic materials, such some problems are pointed out as `CAMD cannot handle an actual size of the target system` and `commercially available software are very expensive.` Reliable tool development as elementary technology, and the verification of its applications are thus required. Meso-dynamics, polymers, surface reaction and integrated technological environment attract users` attention. 27 refs., 16 figs., 2 tabs.

  13. Computer-aided diagnosis for diagnostically challenging breast lesions in DCE-MRI based on image registration and integration of morphologic and dynamic characteristics

    Science.gov (United States)

    Retter, Felix; Plant, Claudia; Burgeth, Bernhard; Botella, Guillermo; Schlossbauer, Thomas; Meyer-Bäse, Anke

    2013-12-01

    Diagnostically challenging lesions comprise both foci (small lesions) and non-mass-like enhancing lesions and pose a challenge to current computer-aided diagnosis systems. Motion-based artifacts lead in dynamic contrast-enhanced breast magnetic resonance to diagnostic misinterpretation; therefore, motion compensation represents an important prerequisite to automatic lesion detection and diagnosis. In addition, the extraction of pertinent kinetic and morphologic features as lesion descriptors is an equally important task. In the present paper, we evaluate the performance of a computer-aided diagnosis system consisting of motion correction, lesion segmentation, and feature extraction and classification. We develop a new feature extractor, the radial Krawtchouk moment, which guarantees rotation invariance. Many novel feature extraction techniques are proposed and tested in conjunction with lesion detection. Our simulation results have shown that motion compensation combined with Minkowski functionals and Bayesian classifier can improve lesion detection and classification.

  14. Desktop Computing Integration Project

    Science.gov (United States)

    Tureman, Robert L., Jr.

    1992-01-01

    The Desktop Computing Integration Project for the Human Resources Management Division (HRMD) of LaRC was designed to help division personnel use personal computing resources to perform job tasks. The three goals of the project were to involve HRMD personnel in desktop computing, link mainframe data to desktop capabilities, and to estimate training needs for the division. The project resulted in increased usage of personal computers by Awards specialists, an increased awareness of LaRC resources to help perform tasks, and personal computer output that was used in presentation of information to center personnel. In addition, the necessary skills for HRMD personal computer users were identified. The Awards Office was chosen for the project because of the consistency of their data requests and the desire of employees in that area to use the personal computer.

  15. Computer Aided Drug Design: Success and Limitations.

    Science.gov (United States)

    Baig, Mohammad Hassan; Ahmad, Khurshid; Roy, Sudeep; Ashraf, Jalaluddin Mohammad; Adil, Mohd; Siddiqui, Mohammad Haris; Khan, Saif; Kamal, Mohammad Amjad; Provazník, Ivo; Choi, Inho

    2016-01-01

    Over the last few decades, computer-aided drug design has emerged as a powerful technique playing a crucial role in the development of new drug molecules. Structure-based drug design and ligand-based drug design are two methods commonly used in computer-aided drug design. In this article, we discuss the theory behind both methods, as well as their successful applications and limitations. To accomplish this, we reviewed structure based and ligand based virtual screening processes. Molecular dynamics simulation, which has become one of the most influential tool for prediction of the conformation of small molecules and changes in their conformation within the biological target, has also been taken into account. Finally, we discuss the principles and concepts of molecular docking, pharmacophores and other methods used in computer-aided drug design.

  16. Computer-Aided Modelling Methods and Tools

    DEFF Research Database (Denmark)

    Cameron, Ian; Gani, Rafiqul

    2011-01-01

    The development of models for a range of applications requires methods and tools. In many cases a reference model is required that allows the generation of application specific models that are fit for purpose. There are a range of computer aided modelling tools available that help to define...... a taxonomy of aspects around conservation, constraints and constitutive relations. Aspects of the ICAS-MoT toolbox are given to illustrate the functionality of a computer aided modelling tool, which incorporates an interface to MS Excel....

  17. Computer Aided Modelling – Opportunities and Challenges

    DEFF Research Database (Denmark)

    2011-01-01

    This chapter considers the opportunities that are present in developing, extending and applying aspects of computer-aided modelling principles and practice. What are the best tasks to be done by modellers and what needs the application of CAPE tools? How do we efficiently develop model-based solu......This chapter considers the opportunities that are present in developing, extending and applying aspects of computer-aided modelling principles and practice. What are the best tasks to be done by modellers and what needs the application of CAPE tools? How do we efficiently develop model...

  18. Computer-Aided Parallelizer and Optimizer

    Science.gov (United States)

    Jin, Haoqiang

    2011-01-01

    The Computer-Aided Parallelizer and Optimizer (CAPO) automates the insertion of compiler directives (see figure) to facilitate parallel processing on Shared Memory Parallel (SMP) machines. While CAPO currently is integrated seamlessly into CAPTools (developed at the University of Greenwich, now marketed as ParaWise), CAPO was independently developed at Ames Research Center as one of the components for the Legacy Code Modernization (LCM) project. The current version takes serial FORTRAN programs, performs interprocedural data dependence analysis, and generates OpenMP directives. Due to the widely supported OpenMP standard, the generated OpenMP codes have the potential to run on a wide range of SMP machines. CAPO relies on accurate interprocedural data dependence information currently provided by CAPTools. Compiler directives are generated through identification of parallel loops in the outermost level, construction of parallel regions around parallel loops and optimization of parallel regions, and insertion of directives with automatic identification of private, reduction, induction, and shared variables. Attempts also have been made to identify potential pipeline parallelism (implemented with point-to-point synchronization). Although directives are generated automatically, user interaction with the tool is still important for producing good parallel codes. A comprehensive graphical user interface is included for users to interact with the parallelization process.

  19. Computer-Aided Pneumatic Circuit Design

    OpenAIRE

    TEKİNER, Zafer; KORKUT, İhsan

    2001-01-01

    In this study, a user-interactive computer program was developed for computer-aided pneumatic circuit design. The pneumatic circuit elements were selected and designed by the determination of the main principles that are in accordance with the aim the user is going to specify. A database was established by forming IGES files for pneumatic circuit elements. In addition to this database, lists displaying the connection nodes of each element were prepared. The coordinates will be conne...

  20. Computer-Aided Corrosion Program Management

    Science.gov (United States)

    MacDowell, Louis

    2010-01-01

    This viewgraph presentation reviews Computer-Aided Corrosion Program Management at John F. Kennedy Space Center. The contents include: 1) Corrosion at the Kennedy Space Center (KSC); 2) Requirements and Objectives; 3) Program Description, Background and History; 4) Approach and Implementation; 5) Challenges; 6) Lessons Learned; 7) Successes and Benefits; and 8) Summary and Conclusions.

  1. Computer Aided Learning of Mathematics: Software Evaluation

    Science.gov (United States)

    Yushau, B.; Bokhari, M. A.; Wessels, D. C. J.

    2004-01-01

    Computer Aided Learning of Mathematics (CALM) has been in use for some time in the Prep-Year Mathematics Program at King Fahd University of Petroleum & Minerals. Different kinds of software (both locally designed and imported) have been used in the quest of optimizing the recitation/problem session hour of the mathematics classes. This paper…

  2. Computer Aided Continuous Time Stochastic Process Modelling

    DEFF Research Database (Denmark)

    Kristensen, N.R.; Madsen, Henrik; Jørgensen, Sten Bay

    2001-01-01

    A grey-box approach to process modelling that combines deterministic and stochastic modelling is advocated for identification of models for model-based control of batch and semi-batch processes. A computer-aided tool designed for supporting decision-making within the corresponding modelling cycle...

  3. Computer aided pantograph design for garment panels

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Discusses the difficulties and problems with manual pantograph ofgarment panels, introduces several typical pantographic ways and their characteristics both at home and abroad, presents a new pantographic method based on similar figures developed to overcome the deficiency of those methods, so as to realize computer aid automatic panel pantograph.

  4. PACS-Based Computer-Aided Detection and Diagnosis

    Science.gov (United States)

    Huang, H. K. (Bernie); Liu, Brent J.; Le, Anh HongTu; Documet, Jorge

    The ultimate goal of Picture Archiving and Communication System (PACS)-based Computer-Aided Detection and Diagnosis (CAD) is to integrate CAD results into daily clinical practice so that it becomes a second reader to aid the radiologist's diagnosis. Integration of CAD and Hospital Information System (HIS), Radiology Information System (RIS) or PACS requires certain basic ingredients from Health Level 7 (HL7) standard for textual data, Digital Imaging and Communications in Medicine (DICOM) standard for images, and Integrating the Healthcare Enterprise (IHE) workflow profiles in order to comply with the Health Insurance Portability and Accountability Act (HIPAA) requirements to be a healthcare information system. Among the DICOM standards and IHE workflow profiles, DICOM Structured Reporting (DICOM-SR); and IHE Key Image Note (KIN), Simple Image and Numeric Report (SINR) and Post-processing Work Flow (PWF) are utilized in CAD-HIS/RIS/PACS integration. These topics with examples are presented in this chapter.

  5. Computer-aided design–computer-aided engineering associative feature-based heterogeneous object modeling

    Directory of Open Access Journals (Sweden)

    Jikai Liu

    2015-12-01

    Full Text Available Conventionally, heterogeneous object modeling methods paid limited attention to the concurrent modeling of geometry design and material composition distribution. Procedural method was normally employed to generate the geometry first and then determine the heterogeneous material distribution, which ignores the mutual influence. Additionally, limited capability has been established about irregular material composition distribution modeling with strong local discontinuities. This article overcomes these limitations by developing the computer-aided design–computer-aided engineering associative feature-based heterogeneous object modeling method. Level set functions are applied to model the geometry within computer-aided design module, which enables complex geometry modeling. Finite element mesh is applied to store the local material compositions within computer-aided engineering module, which allows any local discontinuities. Then, the associative feature concept builds the correspondence relationship between these modules. Additionally, the level set geometry and material optimization method are developed to concurrently generate the geometry and material information which fills the contents of the computer-aided design–computer-aided engineering associative feature model. Micro-geometry is investigated as well, instead of only the local material composition. A few cases are studied to prove the effectiveness of this new heterogeneous object modeling method.

  6. Creating illusion in computer aided performance

    OpenAIRE

    Marshall, Joe

    2009-01-01

    This thesis studies the creation of illusion in computer aided performance. Illusion is created here by using deceptions, and a design framework is presented which suggests several different deception strategies which may be useful. The framework has been developed in an iterative process in tandem with the development of 3 real world performances which were used to explore deception strategies. The first case study presents a system for augmenting juggling performance. The techniques tha...

  7. Genetic algorithms in computer aided inductor design

    OpenAIRE

    Jean Fivaz; Willem A. Cronjé

    2004-01-01

    The goal of this investigation is to determine the advantages of using genetic algorithms in computer-aided design as applied to inductors.  These advantages are exploited in design problems with a number of specifications and constraints, as encountered in power electronics during practical inductor design. The design tool should be able to select components, such as cores and wires, from databases of available components, and evaluate these choices based on the components’ characteristic d...

  8. Computer-aided dispatching system design specification

    Energy Technology Data Exchange (ETDEWEB)

    Briggs, M.G.

    1997-12-16

    This document defines the performance requirements for a graphic display dispatching system to support Hanford Patrol Operations Center. This document reflects the as-built requirements for the system that was delivered by GTE Northwest, Inc. This system provided a commercial off-the-shelf computer-aided dispatching system and alarm monitoring system currently in operations at the Hanford Patrol Operations Center, Building 2721E. This system also provides alarm back-up capability for the Plutonium Finishing Plant (PFP).

  9. Computer Aided Design System for Developing Musical Fountain Programs

    Institute of Scientific and Technical Information of China (English)

    刘丹; 张乃尧; 朱汉城

    2003-01-01

    A computer aided design system for developing musical fountain programs was developed with multiple functions such as intelligent design, 3-D animation, manual modification and synchronized motion to make the development process more efficient. The system first analyzed the music form and sentiment using many basic features of the music to select a basic fountain program. Then, this program is simulated with 3-D animation and modified manually to achieve the desired results. Finally, the program is transformed to a computer control program to control the musical fountain in time with the music. A prototype system for the musical fountain was also developed. It was tested with many styles of music and users were quite satisfied with its performance. By integrating various functions, the proposed computer aided design system for developing musical fountain programs greatly simplified the design of the musical fountain programs.

  10. Computer-aided power systems analysis

    CERN Document Server

    Kusic, George

    2008-01-01

    Computer applications yield more insight into system behavior than is possible by using hand calculations on system elements. Computer-Aided Power Systems Analysis: Second Edition is a state-of-the-art presentation of basic principles and software for power systems in steady-state operation. Originally published in 1985, this revised edition explores power systems from the point of view of the central control facility. It covers the elements of transmission networks, bus reference frame, network fault and contingency calculations, power flow on transmission networks, generator base power setti

  11. System of diagnosis of generators computer aided integrated into a movable laboratory; Sistema de diagnostico de generadores asistido por computadora integrado a un laboratorio movil

    Energy Technology Data Exchange (ETDEWEB)

    De la Torre Vega, H. Octavio; Escorsa Morales, Oscar; Castaneda Parra, Adelina; Garcia- Colon H, Rodolfo [Instituto de Investigaciones Electricas, Temixco, Morelos (Mexico); Lopez Azamar, Ernesto [Comision Federal de Electricidad (Mexico)

    1999-07-01

    The development of the Movable Laboratory is presented, which will allow to combine and document the knowledge acquired by more than ten years of experience in diagnosis of electrical generators. The development of the project is divided into three main parts: laboratory design, data acquisition system (Datec) and system of diagnosis of generators computer aided (Cadis). [Spanish] Se presenta el desarrollo del Laboratorio Movil, el cual permitira conjuntar y documentar el conocimiento adquirido por mas de diez anos de experiencia en diagnostico de generadores electricos. El desarrollo del proyecto se divide en tres grandes partes: diseno de laboratorio, sistema de adquisicion de datos (Datec) y sistema de diagnostico de generadores asistido por computadora (Cadis).

  12. Computer Aided Software Engineering workstation evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Kotcher, D.A.; Parish, R.B.; Sisson, A.M.; Wenzel, W.A.; Wiancko, B.E.

    1988-09-14

    This report presents an evaluation of interconnected high performance workstations. The evaluation specifically addresses the benefits to personnel engaged in Computer Aided Software Engineering (CASE) for the design and development of computer software aided by computer workstations. To narrow the scope of the CASE evaluation to a reasonable size, the class of workstations considered was limited to units having the following minimum capabilities: speed to issue 2 to 3 million instructions per second (Mips), 4 megabytes (MB) of central memory, 140 MB of local disk storage, a monitor with 1024 by 960 graphics resolution, and Ethernet compatibility. In addition, software requirements included a virtual memory implementation of the UNIX operating system, the defacto standard networking Transmission Control Protocol and Internet Protocol (TCP/IP), and the network file system (NFS). Support of selected third-party software, such as the TEMPLATE graphics software, and robust tools for software development were also required. These criteria are justified by the use of workstations for maintenance and support of large mainframe based FORTRAN computer programs. The evaluation concluded that workstations are excellent tools for CASE. 1 ref., 1 fig., 6 tabs.

  13. Computer-Aided Simulation of Mastoidectomy

    Institute of Scientific and Technical Information of China (English)

    CHEN He-xin; MA Zhi-chao; Wang Zhang-feng; GUO Jie-bo; WEN Wei-ping; XU Geng

    2008-01-01

    Objective To establish a three-dimensional model of the temporal bone using CT scan images for study of temporal bone structures and simulation of mastoidectomy procedures. Methods CT scan images from 6 individuals (12 temporal bones) were used to reconstruct the Fallopian canal, internal auditory canal, cochlea, semicircular canals, sigmoid sinus, posterior fossa floor and jugular bulb on a computer platform. Their anatomical relations within the temporal bone were restored in the computed model. The same model was used to simulate mastoidectomy procedures. Results The reconstructed computer model provided accurate and clear three-dimensional images of temporal bone structures. Simulation of mastoidectomy using these images provided procedural experiences closely mimicking the real surgical procedure. Conclusion Computeraided three dimensional reconstruction of temporal bone structures using CT scan images is a useful tool in surgical simulation and can aid surgical procedure planning.

  14. Computer-aided light sheet flow visualization using photogrammetry

    Science.gov (United States)

    Stacy, Kathryn; Severance, Kurt; Childers, Brooks A.

    1994-01-01

    A computer-aided flow visualization process has been developed to analyze video images acquired from rotating and translating light sheet visualization systems. The computer process integrates a mathematical model for image reconstruction, advanced computer graphics concepts, and digital image processing to provide a quantitative and a visual analysis capability. The image reconstruction model, based on photogrammetry, uses knowledge of the camera and light sheet locations and orientations to project two-dimensional light sheet video images into three-dimensional space. A sophisticated computer visualization package, commonly used to analyze computational fluid dynamics (CFD) results, was chosen to interactively display the reconstructed light sheet images with the numerical surface geometry for the model or aircraft under study. The photogrammetric reconstruction technique and the image processing and computer graphics techniques and equipment are described. Results of the computer-aided process applied to both a wind tunnel translating light sheet experiment and an in-flight rotating light sheet experiment are presented. The capability to compare reconstructed experimental light sheet images with CFD solutions in the same graphics environment is also demonstrated.

  15. Computer-aided design of conveyor belts

    Energy Technology Data Exchange (ETDEWEB)

    Karolewski, B.; Pytel, J.

    1984-01-01

    Possibilities are discussed for using mathematical models of belt conveyors for development of computer-aided design of conveyors for coal mining. Examples of optimization tasks and methods for their solution using computerized simulation are analyzed. The analysis is illustrated by an algorithm used to design a starter for the drive system of a belt conveyor. Electromagnetic moment and starting current are used as optimization criteria. A simplified model of a belt conveyor is used. The model consists of an equation of motion with variable braking moment and variable moment of inertia. 3 references.

  16. Genetic algorithms in computer aided inductor design

    Directory of Open Access Journals (Sweden)

    Jean Fivaz

    2004-09-01

    Full Text Available The goal of this investigation is to determine the advantages of using genetic algorithms in computer-aided design as applied to inductors.  These advantages are exploited in design problems with a number of specifications and constraints, as encountered in power electronics during practical inductor design. The design tool should be able to select components, such as cores and wires, from databases of available components, and evaluate these choices based on the components’ characteristic data read from a database of manufacturers’ data-sheets.  The proposed design must always be practically realizable, as close to the desired specifications as possible and within any specified constraints.

  17. Computer Aided Modelling – Opportunities and Challenges

    DEFF Research Database (Denmark)

    Cameron, Ian; Gani, Rafiqul

    2011-01-01

    -based solutions to significant problems? The important issues of workflow and data flow are discussed together with fit-for-purpose model development. As well, the lack of tools around multiscale modelling provides opportunities for the development of efficient tools to address such challenges. The ability......This chapter considers the opportunities that are present in developing, extending and applying aspects of computer-aided modelling principles and practice. What are the best tasks to be done by modellers and what needs the application of CAPE tools? How do we efficiently develop model...... and opportunities are discussed for such systems....

  18. Speech-enabled Computer-aided Translation

    DEFF Research Database (Denmark)

    Mesa-Lao, Bartolomé

    2014-01-01

    The present study has surveyed post-editor trainees’ views and attitudes before and after the introduction of speech technology as a front end to a computer-aided translation workbench. The aim of the survey was (i) to identify attitudes and perceptions among post-editor trainees before performing...... a post-editing task using automatic speech recognition (ASR); and (ii) to assess the degree to which post-editors’ attitudes and expectations to the use of speech technology changed after actually using it. The survey was based on two questionnaires: the first one administered before the participants...

  19. Computer-aided design of GPCR ligands.

    Science.gov (United States)

    Gutiérrez-de-Terán, Hugo; Keränen, Henrik; Azuaje, Jhonny; Rodríguez, David; Åqvist, Johan; Sotelo, Eddy

    2015-01-01

    The recent availability of several GPCR crystal structures now contributes decisively to the perspective of structure-based ligand design. In this context, computational approaches are extremely helpful, particularly if properly integrated in drug design projects with cooperation between computational and medicinal chemistry teams. Here, we present the pipelines used in one such project, devoted to the design of novel potent and selective antagonists for the different adenosine receptors. The details of the computational strategies are described, and particular attention is given to explain how these procedures can effectively guide the synthesis of novel chemical entities.

  20. Computer Aided Grid Interface: An Interactive CFD Pre-Processor

    Science.gov (United States)

    Soni, Bharat K.

    1997-01-01

    NASA maintains an applications oriented computational fluid dynamics (CFD) efforts complementary to and in support of the aerodynamic-propulsion design and test activities. This is especially true at NASA/MSFC where the goal is to advance and optimize present and future liquid-fueled rocket engines. Numerical grid generation plays a significant role in the fluid flow simulations utilizing CFD. An overall goal of the current project was to develop a geometry-grid generation tool that will help engineers, scientists and CFD practitioners to analyze design problems involving complex geometries in a timely fashion. This goal is accomplished by developing the CAGI: Computer Aided Grid Interface system. The CAGI system is developed by integrating CAD/CAM (Computer Aided Design/Computer Aided Manufacturing) geometric system output and/or Initial Graphics Exchange Specification (IGES) files (including all the NASA-IGES entities), geometry manipulations and generations associated with grid constructions, and robust grid generation methodologies. This report describes the development process of the CAGI system.

  1. A computer-aided continuous assessment system

    Directory of Open Access Journals (Sweden)

    B. C.H. Turton

    1996-12-01

    Full Text Available Universities within the United Kingdom have had to cope with a massive expansion in undergraduate student numbers over the last five years (Committee of Scottish University Principals, 1993; CVCP Briefing Note, 1994. In addition, there has been a move towards modularization and a closer monitoring of a student's progress throughout the year. Since the price/performance ratio of computer systems has continued to improve, Computer- Assisted Learning (CAL has become an attractive option. (Fry, 1990; Benford et al, 1994; Laurillard et al, 1994. To this end, the Universities Funding Council (UFQ has funded the Teaching and Learning Technology Programme (TLTP. However universities also have a duty to assess as well as to teach. This paper describes a Computer-Aided Assessment (CAA system capable of assisting in grading students and providing feedback. In this particular case, a continuously assessed course (Low-Level Languages of over 100 students is considered. Typically, three man-days are required to mark one assessed piece of coursework from the students in this class. Any feedback on how the questions were dealt with by the student are of necessity brief. Most of the feedback is provided in a tutorial session that covers the pitfalls encountered by the majority of the students.

  2. Computer Aided Diagnosis in Digital Mammography

    Directory of Open Access Journals (Sweden)

    "H. Mirzaalian

    2005-08-01

    Full Text Available Introduction & Background: Breast cancer is a lead-ing cause of cancer deaths among women.Early de-tection is the most effective way to reduce mortality. Mammography is the best method for early detection. In order to improve the accuracy of interpretation of mammogram, Computer Aided Diagnosis (CAD sys-tems have been proposed. The main goal of this re-search is to implement one of the algorithms and techniques for the enhancement of mammogram for easier detection of abnormalities. Patients & Methods: In the presented algorithm, morphological methods are used first for removing artifacts. Then thresholding, labeling, and active con-tours methods are used to extract the breast region, which allow the search for abnormalities to be lim-ited to the region of the breast. Finally, Gaussian fil-ter and White Top Hat Transform is used for contrast enhancement of mammogram. This algorithm has been applied on 50 images from Mammography Im-age Analysis Society (MIAS. An expert radiologist then verified improvement on the processed images. Results and Conclusions: Implementing the presented algorithm causes easier and better interpretation of mammogram without increasing the number of false positive and false negative results. Because of the spe-cial shapes and statistical features of abnormal tex-tures, it is possible to apply pattern recognition and artificial intelligence techniques as an aid for diagnos-ing suspicious regions. Research on using some of these techniques to distinguish benign abnormalities from malignant ones is on the way.

  3. Computer aided diagnosis of diabetic peripheral neuropathy

    Science.gov (United States)

    Chekh, Viktor; Soliz, Peter; McGrew, Elizabeth; Barriga, Simon; Burge, Mark; Luan, Shuang

    2014-03-01

    Diabetic peripheral neuropathy (DPN) refers to the nerve damage that can occur in diabetes patients. It most often affects the extremities, such as the feet, and can lead to peripheral vascular disease, deformity, infection, ulceration, and even amputation. The key to managing diabetic foot is prevention and early detection. Unfortunately, current existing diagnostic techniques are mostly based on patient sensations and exhibit significant inter- and intra-observer differences. We have developed a computer aided diagnostic (CAD) system for diabetic peripheral neuropathy. The thermal response of the feet of diabetic patients following cold stimulus is captured using an infrared camera. The plantar foot in the images from a thermal video are segmented and registered for tracking points or specific regions. The temperature recovery of each point on the plantar foot is extracted using our bio-thermal model and analyzed. The regions that exhibit abnormal ability to recover are automatically identified to aid the physicians to recognize problematic areas. The key to our CAD system is the segmentation of infrared video. The main challenges for segmenting infrared video compared to normal digital video are (1) as the foot warms up, it also warms up the surrounding, creating an ever changing contrast; and (2) there may be significant motion during imaging. To overcome this, a hybrid segmentation algorithm was developed based on a number of techniques such as continuous max-flow, model based segmentation, shape preservation, convex hull, and temperature normalization. Verifications of the automatic segmentation and registration using manual segmentation and markers show good agreement.

  4. From Phonomecanocardiography to Phonocardiography computer aided

    Science.gov (United States)

    Granados, J.; Tavera, F.; López, G.; Velázquez, J. M.; Hernández, R. T.; López, G. A.

    2017-01-01

    Due to lack of training doctors to identify many of the disorders in the heart by conventional listening, it is necessary to add an objective and methodological analysis to support this technique. In order to obtain information of the performance of the heart to be able to diagnose heart disease through a simple, cost-effective procedure by means of a data acquisition system, we have obtained Phonocardiograms (PCG), which are images of the sounds emitted by the heart. A program of acoustic, visual and artificial vision recognition was elaborated to interpret them. Based on the results of previous research of cardiologists a code of interpretation of PCG and associated diseases was elaborated. Also a site, within the university campus, of experimental sampling of cardiac data was created. Phonocardiography computer-aided is a viable and low cost procedure which provides additional medical information to make a diagnosis of complex heart diseases. We show some previous results.

  5. Computer-Aided Design of Antimicrobial Peptides

    DEFF Research Database (Denmark)

    Fjell, Christopher D.; Hancock, Robert E.W.; Jenssen, Håvard

    2010-01-01

    chemical parameters with biological activities of the peptide, using statistical methods. In this review we will discuss two different in silico strategies of computer-aided antibacterial peptide design, a linear correlation model build as an extension of traditional principal component analysis (PCA......) and a non-linear artificial neural network model. Studies on structurally diverse peptides, have concluded that the PCA derived model are able to guide the antibacterial peptide design in a meaningful way, however requiring rather a high homology between the peptides in the test-set and the in silico...... library, to ensure a successful prediction. In contrast, the neural network model, though significantly less explored in relation to antimicrobial peptide design, has proven extremely promising, demonstrating impressive prediction success and ranking of random peptide libraries correlating well...

  6. Computer Aided Solvent Selection and Design Framework

    DEFF Research Database (Denmark)

    Mitrofanov, Igor; Conte, Elisa; Abildskov, Jens

    , millions of tons solvents have to be wasted every year [2]. Therefore, it becomes important to minimize and optimize the use of organic solvents as much as possible, to satisfy the “Green Chemistry Principles” [3]. Another challenge is that currently solvent selection relies very much on previous...... is to develop a systematic framework and implement it as software for selection and design of solvents for many applications including organic synthesis, complex reaction systems and solvent-based separations. The solvent selection framework is based on a combination of knowledge from industrial practice...... identification of solvent candidates using special software ProCAMD and ProPred, which are the implementations of computer-aided molecular techniques. The second consists of assigning the RS-indices following the reaction–solvent and then consulting the known solvent database and identifying the set of solvents...

  7. COMPUTER AIDED DESIGN OF CUTTING TOOLS

    Directory of Open Access Journals (Sweden)

    Jakub Matuszak

    2015-11-01

    Full Text Available Correct and stable machining process requires an appropriate cutting tool. In most cases the tool can be selected by using special tool catalogs often available in online version. But in some cases there is a need to design unusual tools, for special treatment, which are not available in tool manufacturers’ catalogs. Proper tool design requires strength and geometric calculations. Moreover, in many cases specific technical documentation is required. By using Computer Aided Design of cutting tools this task can be carried out quickly and with high accuracy. Cutting tool visualization in CAD programs gives a clear overview of the design process. Besides, these programs provide the ability to simulate real machining process. Nowadays, 3D modeling in CAD programs is a fundamental tool for engineers. Therefore, it is important to use them in the education process.

  8. Computer-aided design for metabolic engineering.

    Science.gov (United States)

    Fernández-Castané, Alfred; Fehér, Tamás; Carbonell, Pablo; Pauthenier, Cyrille; Faulon, Jean-Loup

    2014-12-20

    The development and application of biotechnology-based strategies has had a great socio-economical impact and is likely to play a crucial role in the foundation of more sustainable and efficient industrial processes. Within biotechnology, metabolic engineering aims at the directed improvement of cellular properties, often with the goal of synthesizing a target chemical compound. The use of computer-aided design (CAD) tools, along with the continuously emerging advanced genetic engineering techniques have allowed metabolic engineering to broaden and streamline the process of heterologous compound-production. In this work, we review the CAD tools available for metabolic engineering with an emphasis, on retrosynthesis methodologies. Recent advances in genetic engineering strategies for pathway implementation and optimization are also reviewed as well as a range of bionalytical tools to validate in silico predictions. A case study applying retrosynthesis is presented as an experimental verification of the output from Retropath, the first complete automated computational pipeline applicable to metabolic engineering. Applying this CAD pipeline, together with genetic reassembly and optimization of culture conditions led to improved production of the plant flavonoid pinocembrin. Coupling CAD tools with advanced genetic engineering strategies and bioprocess optimization is crucial for enhanced product yields and will be of great value for the development of non-natural products through sustainable biotechnological processes.

  9. Computer-Aided Drug Design Methods.

    Science.gov (United States)

    Yu, Wenbo; MacKerell, Alexander D

    2017-01-01

    Computational approaches are useful tools to interpret and guide experiments to expedite the antibiotic drug design process. Structure-based drug design (SBDD) and ligand-based drug design (LBDD) are the two general types of computer-aided drug design (CADD) approaches in existence. SBDD methods analyze macromolecular target 3-dimensional structural information, typically of proteins or RNA, to identify key sites and interactions that are important for their respective biological functions. Such information can then be utilized to design antibiotic drugs that can compete with essential interactions involving the target and thus interrupt the biological pathways essential for survival of the microorganism(s). LBDD methods focus on known antibiotic ligands for a target to establish a relationship between their physiochemical properties and antibiotic activities, referred to as a structure-activity relationship (SAR), information that can be used for optimization of known drugs or guide the design of new drugs with improved activity. In this chapter, standard CADD protocols for both SBDD and LBDD will be presented with a special focus on methodologies and targets routinely studied in our laboratory for antibiotic drug discoveries.

  10. Removal of Supernumerary Teeth Utilizing a Computer-Aided Design/Computer-Aided Manufacturing Surgical Guide.

    Science.gov (United States)

    Jo, Chanwoo; Bae, Doohwan; Choi, Byungho; Kim, Jihun

    2017-05-01

    Supernumerary teeth need to be removed because they can cause various complications. Caution is needed because their removal can cause damage to permanent teeth or tooth germs in the local vicinity. Surgical guides have recently been used in maxillofacial surgery. Because surgical guides are designed through preoperative analysis by computer-aided design software and fabricated using a 3-dimensional printer applying computer-aided manufacturing technology, they increase the accuracy and predictability of surgery. This report describes 2 cases of removal of a mesiodens-1 from a child and 1 from an adolescent-using a surgical guide; these would have been difficult to remove with conventional surgical methods. Copyright © 2016 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  11. Development of the computer-aided process planning (CAPP system for polymer injection molds manufacturing

    Directory of Open Access Journals (Sweden)

    J. Tepić

    2011-10-01

    Full Text Available Beginning of production and selling of polymer products largely depends on mold manufacturing. The costs of mold manufacturing have significant share in the final price of a product. The best way to improve and rationalize polymer injection molds production process is by doing mold design automation and manufacturing process planning automation. This paper reviews development of a dedicated process planning system for manufacturing of the mold for injection molding, which integrates computer-aided design (CAD, computer-aided process planning (CAPP and computer-aided manufacturing (CAM technologies.

  12. Software For Computer-Aided Design Of Control Systems

    Science.gov (United States)

    Wette, Matthew

    1994-01-01

    Computer Aided Engineering System (CAESY) software developed to provide means to evaluate methods for dealing with users' needs in computer-aided design of control systems. Interpreter program for performing engineering calculations. Incorporates features of both Ada and MATLAB. Designed to be flexible and powerful. Includes internally defined functions, procedures and provides for definition of functions and procedures by user. Written in C language.

  13. Computer-aided drug design at Boehringer Ingelheim

    Science.gov (United States)

    Muegge, Ingo; Bergner, Andreas; Kriegl, Jan M.

    2016-09-01

    Computer-Aided Drug Design (CADD) is an integral part of the drug discovery endeavor at Boehringer Ingelheim (BI). CADD contributes to the evaluation of new therapeutic concepts, identifies small molecule starting points for drug discovery, and develops strategies for optimizing hit and lead compounds. The CADD scientists at BI benefit from the global use and development of both software platforms and computational services. A number of computational techniques developed in-house have significantly changed the way early drug discovery is carried out at BI. In particular, virtual screening in vast chemical spaces, which can be accessed by combinatorial chemistry, has added a new option for the identification of hits in many projects. Recently, a new framework has been implemented allowing fast, interactive predictions of relevant on and off target endpoints and other optimization parameters. In addition to the introduction of this new framework at BI, CADD has been focusing on the enablement of medicinal chemists to independently perform an increasing amount of molecular modeling and design work. This is made possible through the deployment of MOE as a global modeling platform, allowing computational and medicinal chemists to freely share ideas and modeling results. Furthermore, a central communication layer called the computational chemistry framework provides broad access to predictive models and other computational services.

  14. Intelligent Image Based Computer Aided Education (IICAE)

    Science.gov (United States)

    David, Amos A.; Thiery, Odile; Crehange, Marion

    1989-03-01

    Artificial Intelligence (AI) has found its way into Computer Aided Education (CAE), and there are several systems constructed to put in evidence its interesting advantages. We believe that images (graphic or real) play an important role in learning. However, the use of images, outside their use as illustration, makes it necessary to have applications such as AI. We shall develop the application of AI in an image based CAE and briefly present the system under construction to put in evidence our concept. We shall also elaborate a methodology for constructing such a system. Futhermore we shall briefly present the pedagogical and psychological activities in a learning process. Under the pedagogical and psychological aspect of learning, we shall develop areas such as the importance of image in learning both as pedagogical objects as well as means for obtaining psychological information about the learner. We shall develop the learner's model, its use, what to build into it and how. Under the application of AI in an image based CAE, we shall develop the importance of AI in exploiting the knowledge base in the learning environment and its application as a means of implementing pedagogical strategies.

  15. Computer Aided Methods & Tools for Separation & Purification of Fine Chemical & Pharmaceutical Products

    DEFF Research Database (Denmark)

    Afonso, Maria B.C.; Soni, Vipasha; Mitkowski, Piotr Tomasz

    2006-01-01

    aided system. The methods and tools are linked through the problems they are able to solve and the associated data-flow. The integrated computer aided system has been used to solve a number of industrial problems and summarized results from a selection, involving separation and purification issues......An integrated approach that is particularly suitable for solving problems related to product-process design from the fine chemicals, agrochemicals, food and pharmaceutical industries is presented together with the corresponding methods and tools, which forms the basis for an integrated computer...

  16. CAD/CAM (Computer Aided Design/Computer Aided Manufacture). A Brief Guide to Materials in the Library of Congress.

    Science.gov (United States)

    Havas, George D.

    This brief guide to materials in the Library of Congress (LC) on computer aided design and/or computer aided manufacturing lists reference materials and other information sources under 13 headings: (1) brief introductions; (2) LC subject headings used for such materials; (3) textbooks; (4) additional titles; (5) glossaries and handbooks; (6)…

  17. Retrofitting a crown to a sleep apnea device by using computer-aided design and computer-aided milling technology.

    Science.gov (United States)

    Biethman, Rick; Land, Martin F; Hruskocy, Heather; Colgin, Bruce

    2014-07-01

    Retrofitting a new crown to an existing dental device is challenging. The continued evolution of computer-aided design and computer-aided manufacturing (CAD/CAM) significantly simplifies the process. This article demonstrates retrofitting a gold crown to an existing sleep apnea device.

  18. Computer-aided design development transition for IPAD environment

    Science.gov (United States)

    Owens, H. G.; Mock, W. D.; Mitchell, J. C.

    1980-01-01

    The relationship of federally sponsored computer-aided design/computer-aided manufacturing (CAD/CAM) programs to the aircraft life cycle design process, an overview of NAAD'S CAD development program, an evaluation of the CAD design process, a discussion of the current computing environment within which NAAD is developing its CAD system, some of the advantages/disadvantages of the NAAD-IPAD approach, and CAD developments during transition into the IPAD system are discussed.

  19. Computer-Aided Model Based Analysis for Design and Operation of a Copolymerization Process

    DEFF Research Database (Denmark)

    Lopez-Arenas, Maria Teresa; Sales-Cruz, Alfonso Mauricio; Gani, Rafiqul

    2006-01-01

    The advances in computer science and computational algorithms for process modelling, process simulation, numerical methods and design/synthesis algorithms, makes it advantageous and helpful to employ computer-aided modelling systems and tools for integrated process analysis. This is illustrated....... This will allow analysis of the process behaviour, contribute to a better understanding of the polymerization process, help to avoid unsafe conditions of operation, and to develop operational and optimizing control strategies. In this work, through a computer-aided modeling system ICAS-MoT, two first......, the process design and conditions of operation on the polymer grade and the production rate....

  20. Microwave processing of a dental ceramic used in computer-aided design/computer-aided manufacturing.

    Science.gov (United States)

    Pendola, Martin; Saha, Subrata

    2015-01-01

    Because of their favorable mechanical properties and natural esthetics, ceramics are widely used in restorative dentistry. The conventional ceramic sintering process required for their use is usually slow, however, and the equipment has an elevated energy consumption. Sintering processes that use microwaves have several advantages compared to regular sintering: shorter processing times, lower energy consumption, and the capacity for volumetric heating. The objective of this study was to test the mechanical properties of a dental ceramic used in computer-aided design/computer-aided manufacturing (CAD/CAM) after the specimens were processed with microwave hybrid sintering. Density, hardness, and bending strength were measured. When ceramic specimens were sintered with microwaves, the processing times were reduced and protocols were simplified. Hardness was improved almost 20% compared to regular sintering, and flexural strength measurements suggested that specimens were approximately 50% stronger than specimens sintered in a conventional system. Microwave hybrid sintering may preserve or improve the mechanical properties of dental ceramics designed for CAD/CAM processing systems, reducing processing and waiting times.

  1. Adhesive Bonding to Computer-aided Design/ Computer-aided Manufacturing Esthetic Dental Materials: An Overview.

    Science.gov (United States)

    Awad, Mohamed Moustafa; Alqahtani, H; Al-Mudahi, A; Murayshed, M S; Alrahlah, A; Bhandi, Shilpa H

    2017-07-01

    To review the adhesive bonding to different computer-aided design/computer-aided manufacturing (CAD/CAM) esthetic restorative materials. The use of CAD/CAM esthetic restorative materials has gained popularity in recent years. Several CAD/ CAM esthetic restorative materials are commercially available. Adhesive bonding is a major determinant of success of CAD/ CAM restorations. Review result: An account of the currently available bonding strategies are discussed with their rationale in various CAD/ CAM materials. Different surface treatment methods as well as adhesion promoters can be used to achieve reliable bonding of CAD/CAM restorative materials. Selection of bonding strategy to such material is determined based on its composition. Further evidence is required to evaluate the effect of new surface treatment methods, such as nonthermal atmospheric plasma and self-etching ceramic primer on bonding to different dental ceramics. An understanding of the currently available bonding strategies to CA/CAM materials can help the clinician to select the most indicated system for each category of materials.

  2. PLAID- A COMPUTER AIDED DESIGN SYSTEM

    Science.gov (United States)

    Brown, J. W.

    1994-01-01

    PLAID is a three-dimensional Computer Aided Design (CAD) system which enables the user to interactively construct, manipulate, and display sets of highly complex geometric models. PLAID was initially developed by NASA to assist in the design of Space Shuttle crewstation panels, and the detection of payload object collisions. It has evolved into a more general program for convenient use in many engineering applications. Special effort was made to incorporate CAD techniques and features which minimize the users workload in designing and managing PLAID models. PLAID consists of three major modules: the Primitive Object Generator (BUILD), the Composite Object Generator (COG), and the DISPLAY Processor. The BUILD module provides a means of constructing simple geometric objects called primitives. The primitives are created from polygons which are defined either explicitly by vertex coordinates, or graphically by use of terminal crosshairs or a digitizer. Solid objects are constructed by combining, rotating, or translating the polygons. Corner rounding, hole punching, milling, and contouring are special features available in BUILD. The COG module hierarchically organizes and manipulates primitives and other previously defined COG objects to form complex assemblies. The composite object is constructed by applying transformations to simpler objects. The transformations which can be applied are scalings, rotations, and translations. These transformations may be defined explicitly or defined graphically using the interactive COG commands. The DISPLAY module enables the user to view COG assemblies from arbitrary viewpoints (inside or outside the object) both in wireframe and hidden line renderings. The PLAID projection of a three-dimensional object can be either orthographic or with perspective. A conflict analysis option enables detection of spatial conflicts or collisions. DISPLAY provides camera functions to simulate a view of the model through different lenses. Other

  3. 园林计算机辅助设计工学结合课程开发初探%Development of Computer-Aided Landscape Design Program: A Work-Integrated Learning Approach

    Institute of Scientific and Technical Information of China (English)

    刘和平; 林剑波

    2011-01-01

    为培养学生职业能力,提高学生借助计算机绘制园林设计图的能力,笔者探讨了《园林计算机辅助设计》工学结合课程开发.课程开发小组在分析学生学情和园林专业典型工作任务的基础上,围绕课程开发原则,以一个典型的园林项目为载体,将知识内容紧密结合在工作过程中讲授,并制定学习要求,采用项目任务等新的考核方式来综合评价学生的学习质量.%A work-integrated learning approach to the program, Computer-Aided Landscape Design, is put forward to improve their skills in landscape sketch drawing. After an analysis of students' potentials and typical tasks of landscape majors, the program development team conducts a work-integrated learning approach, in which the traditional theory-oriented testing is replaced by a task-driven assessment to evaluate their performance in class.

  4. Computer-Aided Multiscale Modelling for Chemical Process Engineering

    DEFF Research Database (Denmark)

    Morales Rodriguez, Ricardo; Gani, Rafiqul

    2007-01-01

    T) for model translation, analysis and solution. The integration of ModDev, MoT and ICAS or any other external software or process simulator (using COM-Objects) permits the generation of different models and/or process configurations for purposes of simulation, design and analysis. Consequently, it is possible......Chemical processes are generally modeled through monoscale approaches, which, while not adequate, satisfy a useful role in product-process design. In this case, use of a multi-dimensional and multi-scale model-based approach has importance in product-process development. A computer-aided framework...... for model generation, analysis, solution and implementation is necessary for the development and application of the desired model-based approach for product-centric process design/analysis. This goal is achieved through the combination of a system for model development (ModDev), and a modelling tool (Mo...

  5. Computer-aided recording of automatic endoscope washing and disinfection processes as an integral part of medical documentation for quality assurance purposes

    Directory of Open Access Journals (Sweden)

    Klein Stefanie

    2010-07-01

    Full Text Available Abstract Background The reprocessing of medical endoscopes is carried out using automatic cleaning and disinfection machines. The documentation and archiving of records of properly conducted reprocessing procedures is the last and increasingly important part of the reprocessing cycle for flexible endoscopes. Methods This report describes a new computer program designed to monitor and document the automatic reprocessing of flexible endoscopes and accessories in fully automatic washer-disinfectors; it does not contain nor compensate the manual cleaning step. The program implements national standards for the monitoring of hygiene in flexible endoscopes and the guidelines for the reprocessing of medical products. No FDA approval has been obtained up to now. The advantages of this newly developed computer program are firstly that it simplifies the documentation procedures of medical endoscopes and that it could be used universally with any washer-disinfector and that it is independent of the various interfaces and software products provided by the individual suppliers of washer-disinfectors. Results The computer program presented here has been tested on a total of four washer-disinfectors in more than 6000 medical examinations within 9 months. Conclusions We present for the first time an electronic documentation system for automated washer-disinfectors for medical devices e.g. flexible endoscopes which can be used on any washer-disinfectors that documents the procedures involved in the automatic cleaning process and can be easily connected to most hospital documentation systems.

  6. Development and Evaluation of a Computer-Aided Learning (CAL ...

    African Journals Online (AJOL)

    Development and Evaluation of a Computer-Aided Learning (CAL) Package on C++ ... Technology has created a great potential for borderless education. ... packages in the future, thus roviding additional resources for independent learning.

  7. Computer Aided Design Tools for Extreme Environment Electronics Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This project aims to provide Computer Aided Design (CAD) tools for radiation-tolerant, wide-temperature-range digital, analog, mixed-signal, and radio-frequency...

  8. Computer-Aided Qualitative Data Analysis with Word

    Directory of Open Access Journals (Sweden)

    Bruno Nideröst

    2002-05-01

    Full Text Available Despite some fragmentary references in the literature about qualitative methods, it is fairly unknown that Word can be successfully used for computer-aided Qualitative Data Analyses (QDA. Based on several Word standard operations, elementary QDA functions such as sorting data, code-and-retrieve and frequency counts can be realized. Word is particularly interesting for those users who wish to have first experiences with computer-aided analysis before investing time and money in a specialized QDA Program. The well-known standard software could also be an option for those qualitative researchers who usually work with word processing but have certain reservations towards computer-aided analysis. The following article deals with the most important requirements and options of Word for computer-aided QDA. URN: urn:nbn:de:0114-fqs0202225

  9. Computer-aided Translation Technology and Its Applications

    Institute of Scientific and Technical Information of China (English)

    汪美侠; 何大顺

    2014-01-01

    This article begins with a brief analysis of the significance of translation technology in different spheres of modern life, followed by a distinction between machine translation (MT) and computer-aided translation (CAT). It then describes some trans-lation resources and tools and examines the negative and positive aspects of computer-aided translations. Finally it comes to a conclusion that it would be greatly efficient and productive for the translators to acquire the new skills in the translation work-place.

  10. Planning Computer-Aided Distance Learning

    Directory of Open Access Journals (Sweden)

    Nadja Dobnik

    1996-12-01

    Full Text Available Didactics of autonomous learning changes under the influence of new technologies. Computer technology can cover all the functions that a teacher develops in personal contact with the learner. People organizing distance learning must realize all the possibilities offered by computers. Computers can take over and also combine the functions of many tools and systems, e. g. type­ writer, video, telephone. This the contents can be offered in form of classic media by means of text, speech, picture, etc. Computers take over data pro­cessing and function as study materials. Computer included in a computer network can also function as a medium for interactive communication.

  11. Integrated optimisation technique based on computer-aided capacity and safety evaluation for managing downstream lane-drop merging area of signalised junctions

    Science.gov (United States)

    Chen, CHAI; Yiik Diew, WONG

    2017-02-01

    This study provides an integrated strategy, encompassing microscopic simulation, safety assessment, and multi-attribute decision-making, to optimize traffic performance at downstream merging area of signalized intersections. A Fuzzy Cellular Automata (FCA) model is developed to replicate microscopic movement and merging behavior. Based on simulation experiment, the proposed FCA approach is able to provide capacity and safety evaluation of different traffic scenarios. The results are then evaluated through data envelopment analysis (DEA) and analytic hierarchy process (AHP). Optimized geometric layout and control strategies are then suggested for various traffic conditions. An optimal lane-drop distance that is dependent on traffic volume and speed limit can thus be established at the downstream merging area.

  12. A review of computer-aided design/computer-aided manufacture techniques for removable denture fabrication.

    Science.gov (United States)

    Bilgin, Mehmet Selim; Baytaroğlu, Ebru Nur; Erdem, Ali; Dilber, Erhan

    2016-01-01

    The aim of this review was to investigate usage of computer-aided design/computer-aided manufacture (CAD/CAM) such as milling and rapid prototyping (RP) technologies for removable denture fabrication. An electronic search was conducted in the PubMed/MEDLINE, ScienceDirect, Google Scholar, and Web of Science databases. Databases were searched from 1987 to 2014. The search was performed using a variety of keywords including CAD/CAM, complete/partial dentures, RP, rapid manufacturing, digitally designed, milled, computerized, and machined. The identified developments (in chronological order), techniques, advantages, and disadvantages of CAD/CAM and RP for removable denture fabrication are summarized. Using a variety of keywords and aiming to find the topic, 78 publications were initially searched. For the main topic, the abstract of these 78 articles were scanned, and 52 publications were selected for reading in detail. Full-text of these articles was gained and searched in detail. Totally, 40 articles that discussed the techniques, advantages, and disadvantages of CAD/CAM and RP for removable denture fabrication and the articles were incorporated in this review. Totally, 16 of the papers summarized in the table. Following review of all relevant publications, it can be concluded that current innovations and technological developments of CAD/CAM and RP allow the digitally planning and manufacturing of removable dentures from start to finish. As a result according to the literature review CAD/CAM techniques and supportive maxillomandibular relationship transfer devices are growing fast. In the close future, fabricating removable dentures will become medical informatics instead of needing a technical staff and procedures. However the methods have several limitations for now.

  13. Cheap computer aids for medical photography departments.

    Science.gov (United States)

    Jankowski, R A

    1989-01-01

    Most departments now use computers to assist in administration. Choice of hardware and software is very much dependent upon the complexity of the tasks and also on the amount of money available to purchase such equipment. This paper gives an insight into how a low cost computer system is successfully introduced into a department and is proving good value for money.

  14. Helping Alleviate Statistical Anxiety with Computer Aided Statistical Classes

    Science.gov (United States)

    Stickels, John W.; Dobbs, Rhonda R.

    2007-01-01

    This study, Helping Alleviate Statistical Anxiety with Computer Aided Statistics Classes, investigated whether undergraduate students' anxiety about statistics changed when statistics is taught using computers compared to the traditional method. Two groups of students were questioned concerning their anxiety about statistics. One group was taught…

  15. The Journal of Computer- Aided Molecular Design: a bibliometric note

    Science.gov (United States)

    Willett, Peter

    2012-01-01

    Summarizes the articles in, and the citations to, volumes 2-24 of the Journal of Computer- Aided Molecular Design. The citations to the journal come from almost 2000 different sources that span a very wide range of academic subjects, with the most heavily cited articles being descriptions of software systems and of computational methods.

  16. A Multi-step and Multi-level approach for Computer Aided Molecular Design

    DEFF Research Database (Denmark)

    A general multi-step approach for setting up, solving and solution analysis of computer aided molecular design (CAMD) problems is presented. The approach differs from previous work within the field of CAMD since it also addresses the need for a computer aided problem formulation and result analysis....... The problem formulation step incorporates a knowledge base for the identification and setup of the design criteria. Candidate compounds are identified using a multi-level generate and test CAMD solution algorithm capable of designing molecules having a high level of molecular detail. A post solution step...... using an Integrated Computer Aided System (ICAS) for result analysis and verification is included in the methodology. Keywords: CAMD, separation processes, knowledge base, molecular design, solvent selection, substitution, group contribution, property prediction, ICAS Introduction The use of Computer...

  17. Using the Web To Improve Computer-Aided Instruction in Economics.

    Science.gov (United States)

    Daniel, Joseph I.

    1999-01-01

    Believes that the World Wide Web has great potential for delivering interactive computer-aided instruction using programming language like Java and Javascript. Describes a website on object-oriented microeconomics that integrates a textbook, mini-lecture series, graphical calculator, animated drawing program, spreadsheet, and regression package.…

  18. Incorporating Computer-Aided Software in the Undergraduate Chemical Engineering Core Courses

    Science.gov (United States)

    Alnaizy, Raafat; Abdel-Jabbar, Nabil; Ibrahim, Taleb H.; Husseini, Ghaleb A.

    2014-01-01

    Introductions of computer-aided software and simulators are implemented during the sophomore-year of the chemical engineering (ChE) curriculum at the American University of Sharjah (AUS). Our faculty concurs that software integration within the curriculum is beneficial to our students, as evidenced by the positive feedback received from industry…

  19. Incorporating Computer-Aided Software in the Undergraduate Chemical Engineering Core Courses

    Science.gov (United States)

    Alnaizy, Raafat; Abdel-Jabbar, Nabil; Ibrahim, Taleb H.; Husseini, Ghaleb A.

    2014-01-01

    Introductions of computer-aided software and simulators are implemented during the sophomore-year of the chemical engineering (ChE) curriculum at the American University of Sharjah (AUS). Our faculty concurs that software integration within the curriculum is beneficial to our students, as evidenced by the positive feedback received from industry…

  20. Computer-Aided Air-Traffic Control In The Terminal Area

    Science.gov (United States)

    Erzberger, Heinz

    1995-01-01

    Developmental computer-aided system for automated management and control of arrival traffic at large airport includes three integrated subsystems. One subsystem, called Traffic Management Advisor, another subsystem, called Descent Advisor, and third subsystem, called Final Approach Spacing Tool. Data base that includes current wind measurements and mathematical models of performances of types of aircraft contributes to effective operation of system.

  1. Computer Aided Data Analysis in Sociometry

    Science.gov (United States)

    Langeheine, Rolf

    1978-01-01

    A computer program which analyzes sociometric data is presented. The SDAS program provides classical sociometric analysis. Multi-dimensional scaling and cluster analysis techniques may be combined with the MSP program. (JKS)

  2. Computer-aided hepatic tumour ablation

    CERN Document Server

    Voirin, D; Amavizca, M; Leroy, A; Letoublon, C; Troccaz, J; Voirin, David; Payan, Yohan; Amavizca, Miriam; Leroy, Antoine; Letoublon, Christian; Troccaz, Jocelyne

    2001-01-01

    Surgical resection of hepatic tumours is not always possible. Alternative techniques consist in locally using chemical or physical agents to destroy the tumour and this may be performed percutaneously. It requires a precise localisation of the tumour placement during ablation. Computer-assisted surgery tools may be used in conjunction to these new ablation techniques to improve the therapeutic efficiency whilst benefiting from minimal invasiveness. This communication introduces the principles of a system for computer-assisted hepatic tumour ablation.

  3. COMPUTER-AIDED ACQUISITION OF WRITING SKILLS

    NARCIS (Netherlands)

    Verhoef, R.; Tomic, W.

    2008-01-01

    This article presents the results of a review of the literature questioning whether and to what extent computers can be used as a means of instruction for the guided acquisition of communicative writing skills in higher education. To answer this question, the present paper first explores the charact

  4. COMPUTER-AIDED ACQUISITION OF WRITING SKILLS

    NARCIS (Netherlands)

    Verhoef, R.; Tomic, W.

    2008-01-01

    This article presents the results of a review of the literature questioning whether and to what extent computers can be used as a means of instruction for the guided acquisition of communicative writing skills in higher education. To answer this question, the present paper first explores the

  5. Developments in Computer Aided Software Maintenance

    Science.gov (United States)

    1974-09-01

    differences in intelligence ( Adorno et al, 1950). The present authors speculate, however, that there may be a correlation between programming ability and...Administrative Side." Computer Decisions, October 1973. Adorno , T.W., Frenkel-Brunswick, E., Levinson, D.J., and Sanford, R.N. The Authoritarian

  6. Case Based Reasoning Intelligent System for Network Computer Aided Process Planning

    Institute of Scientific and Technical Information of China (English)

    ZHAO Chunhua; WU Zhengjia; ZHOU Chengjun; ZHU Dalin; LI Haoping

    2006-01-01

    Computer aided process planning system played a key role for integrating design and manufacturing or assembly systems properly considering available resources and design constraints. To take advantage of the enterprise resource, the web CAPP framework was established. Case based reasoning and multi agent system were integrated in the system. The multi agent mechanism was discussed in the paper. And an instance of case base was introduced. They made the system run independently and continuously in the network environment of process planning problems.

  7. An integrated introduction to computer graphics and geometric modeling

    CERN Document Server

    Goldman, Ronald

    2009-01-01

    … this book may be the first book on geometric modelling that also covers computer graphics. In addition, it may be the first book on computer graphics that integrates a thorough introduction to 'freedom' curves and surfaces and to the mathematical foundations for computer graphics. … the book is well suited for an undergraduate course. … The entire book is very well presented and obviously written by a distinguished and creative researcher and educator. It certainly is a textbook I would recommend. …-Computer-Aided Design, 42, 2010… Many books concentrate on computer programming and soon beco

  8. Performative Computation-aided Design Optimization

    Directory of Open Access Journals (Sweden)

    Ming Tang

    2012-12-01

    Full Text Available This article discusses a collaborative research and teaching project between the University of Cincinnati, Perkins+Will’s Tech Lab, and the University of North Carolina Greensboro. The primary investigation focuses on the simulation, optimization, and generation of architectural designs using performance-based computational design approaches. The projects examine various design methods, including relationships between building form, performance and the use of proprietary software tools for parametric design.

  9. Mathematical modelling in the computer-aided process planning

    Science.gov (United States)

    Mitin, S.; Bochkarev, P.

    2016-04-01

    This paper presents new approaches to organization of manufacturing preparation and mathematical models related to development of the computer-aided multi product process planning (CAMPP) system. CAMPP system has some peculiarities compared to the existing computer-aided process planning (CAPP) systems: fully formalized developing of the machining operations; a capacity to create and to formalize the interrelationships among design, process planning and process implementation; procedures for consideration of the real manufacturing conditions. The paper describes the structure of the CAMPP system and shows the mathematical models and methods to formalize the design procedures.

  10. Computer Aided Facial Prosthetics Manufacturing System

    Directory of Open Access Journals (Sweden)

    Peng H.K.

    2016-01-01

    Full Text Available Facial deformities can impose burden to the patient. There are many solutions for facial deformities such as plastic surgery and facial prosthetics. However, current fabrication method of facial prosthetics is high-cost and time consuming. This study aimed to identify a new method to construct a customized facial prosthetic. A 3D scanner, computer software and 3D printer were used in this study. Results showed that the new developed method can be used to produce a customized facial prosthetics. The advantages of the developed method over the conventional process are low cost, reduce waste of material and pollution in order to meet the green concept.

  11. Computer-aided Analysis of Phisiological Systems

    Directory of Open Access Journals (Sweden)

    Balázs Benyó

    2007-12-01

    Full Text Available This paper presents the recent biomedical engineering research activity of theMedical Informatics Laboratory at the Budapest University of Technology and Economics.The research projects are carried out in the fields as follows: Computer aidedidentification of physiological systems; Diabetic management and blood glucose control;Remote patient monitoring and diagnostic system; Automated system for analyzing cardiacultrasound images; Single-channel hybrid ECG segmentation; Event recognition and stateclassification to detect brain ischemia by means of EEG signal processing; Detection ofbreathing disorders like apnea and hypopnea; Molecular biology studies with DNA-chips;Evaluation of the cry of normal hearing and hard of hearing infants.

  12. Data-driven computer aided synthesis design.

    Science.gov (United States)

    Ravitz, Orr

    2013-09-01

    Enabled by an increasing body of electronically available experimental data and by advances in computer hardware and software, new technologies are emerging that are designed to support the creativity of chemists during synthesis planning. Leading this development are innovative synthetic route prediction tools that are designed to suggest new reactions and paths to target molecules as an idea-generating engine. Other tools are using known reactions in a combinatorial fashion to suggest new routes that are cost-optimized or satisfy some other global criteria. We review the latest developments and the main tools in this domain.

  13. Computer-aided forensics: facial reconstruction.

    Science.gov (United States)

    Turner, Wesley; Tu, Peter; Kelliher, Timothy; Brown, Rebecca

    2006-01-01

    The 3D reconstruction of facial features from skeletal remains is a key component to the identification of missing persons and victims of violent crime. A comprehensive Computed Tomography (CT) head-scan database is currently being collected which will enable a new approach to forensic facial reconstruction. Using this unique resource, we show how a face space can be tailored to a specific unknown, or questioned skull. A set of database derived estimates of the questioned face is constructed by first computing non-rigid transformations between the known head-scan skulls and the questioned skull followed by application of these transformations to the known head-scan faces. This effectively factors out influences due to skeletal variation. A tailored face space is formed by applying Principal Component Analysis (PCA) to this ensemble of estimates of the questioned face. Thus, the face space is a direct approximation of correlated soft tissue variance indicative of the population. Ours is the first mathematical representation of the face continuum associated with a given skull. Embedded in this space resides the elements needed for recognition.

  14. The Modern Hearing Aid – an Extreme System Integration Challenge

    DEFF Research Database (Denmark)

    Jørgensen, Ivan Harald Holger

    People with reduced hearing generally want to hide this disability and thus the size of hearing aids is constantly decreasing in the effort to make them virtually invisible. However, as for all other modern electrical devices more and more features are constantly added to hearing aids driven...... by the development in modern IC technology. This has resulted in the modern hearing aid being highly advanced devices where the demands for performance and features at very low supply voltage and power consumption constantly prove a huge challenge to the physical design of hearing aids and not at least the design...... of the ICs for these. This leads to very large demands for system integration at the packing level, SiP (System-in-Package), and not at least at the IC level, SoC (System-on-Chip). As a result of this all large hearing aid manufactures use custom package technology which again uses fully customized ASICs...

  15. Electromagnetic tracking for abdominal interventions in computer aided surgery.

    Science.gov (United States)

    Zhang, Hui; Banovac, Filip; Lin, Ralph; Glossop, Neil; Wood, Bradford J; Lindisch, David; Levy, Elliot; Cleary, Kevin

    2006-05-01

    Electromagnetic tracking has great potential for assisting physicians in precision placement of instruments during minimally invasive interventions in the abdomen, since electromagnetic tracking is not limited by the line-of-sight restrictions of optical tracking. A new generation of electromagnetic tracking has recently become available, with sensors small enough to be included in the tips of instruments. To fully exploit the potential of this technology, our research group has been developing a computer aided, image-guided system that uses electromagnetic tracking for visualization of the internal anatomy during abdominal interventions. As registration is a critical component in developing an accurate image-guided system, we present three registration techniques: 1) enhanced paired-point registration (time-stamp match registration and dynamic registration); 2) orientation-based registration; and 3) needle shape-based registration. Respiration compensation is another important issue, particularly in the abdomen, where respiratory motion can make precise targeting difficult. To address this problem, we propose reference tracking and affine transformation methods. Finally, we present our prototype navigation system, which integrates the registration, segmentation, path-planning and navigation functions to provide real-time image guidance in the clinical environment. The methods presented here have been tested with a respiratory phantom specially designed by our group and in swine animal studies under approved protocols. Based on these tests, we conclude that our system can provide quick and accurate localization of tracked instruments in abdominal interventions, and that it offers a user-friendly display for the physician.

  16. [Computer-aided electronic prescribing in Spanish hospitals].

    Science.gov (United States)

    Rubio Fernández, M; Aldaz Francés, R; García Gómez, C; Valladolid Walsh, A

    2005-01-01

    To describe electronic prescribing in a sample of Spanish hospitals and activities derived from its implementation in Hospital Pharmacy Departments, software features and acceptance. A survey that included data related to program implantation and performance in hospitals with diverse characteristics was designed. It was posted at the Sociedad Española de Farmacia Hospitalaria website for a 6-month period and completed by phone. A total of 47 hospitals answered the survey. 13 (27.7%) had electronic prescribing systems, and of these, 8 of them had more than 75% of beds included in the system. In 15 (31.9%) hospitals that did not have it, its implementation was in project in the near future. Software applications used in this new health technology were not homogeneous, while integration of applications that facilitate Pharmaceutical Care tasks was infrequent. In 61.5% of the hospitals with electronic prescribing, transcription used to be the pharmacist s task. In 92.3% of these hospitals, order validation is currently carried out by pharmacists. The degree of satisfaction with the system was rated as good or very good by 92.3% of pharmacists. Computer-aided electronic prescribing appears to be a helpful tool for restructuring Department organization and investing time in new activities. A more ambitious and effective approach to clinical activities will therefore be possible. System optimization requires taking into account factors such as worker time investment, since new activities will be developed, along with the need for training courses.

  17. A critically appraised topic review of computer-aided design/computer-aided machining of removable partial denture frameworks.

    Science.gov (United States)

    Lang, Lisa A; Tulunoglu, Ibrahim

    2014-01-01

    A critically appraised topic (CAT) review is presented about the use of computer-aided design (CAD)/computer-aided machining (CAM) removable partial denture (RPD) frameworks. A systematic search of the literature supporting CAD/CAM RPD systems revealed no randomized clinical trials, hence the CAT review was performed. A PubMed search yielded 9 articles meeting the inclusion criteria. Each article was characterized by study design and level of evidence. No clinical outcomes research has been published on the use of CAD/CAM RPDs. Low levels of evidence were found in the available literature. Clinical research studies are needed to determine the efficacy of this treatment modality.

  18. Computer-Aided Numerical Inversion of Laplace Transform

    OpenAIRE

    Umesh Kumar

    2000-01-01

    This paper explores the technique for the computer aided numerical inversion of Laplace transform. The inversion technique is based on the properties of a family of three parameter exponential probability density functions. The only limitation in the technique is the word length of the computer being used. The Laplace transform has been used extensively in the frequency domain solution of linear, lumped time invariant networks but its application to the time domain has been limited, mainly be...

  19. Computer-aided modelling template: Concept and application

    DEFF Research Database (Denmark)

    Fedorova, Marina; Sin, Gürkan; Gani, Rafiqul

    2015-01-01

    decomposition technique which identifies generic steps and workflow involved, the computer-aided template concept has been developed. This concept is implemented as a software tool, which provides a user-friendly interface for following the workflow steps and guidance through the steps providing additional...

  20. Computational modelling of the impact of AIDS on business.

    Science.gov (United States)

    Matthews, Alan P

    2007-07-01

    An overview of computational modelling of the impact of AIDS on business in South Africa, with a detailed description of the AIDS Projection Model (APM) for companies, developed by the author, and suggestions for further work. Computational modelling of the impact of AIDS on business in South Africa requires modelling of the epidemic as a whole, and of its impact on a company. This paper gives an overview of epidemiological modelling, with an introduction to the Actuarial Society of South Africa (ASSA) model, the most widely used such model for South Africa. The APM produces projections of HIV prevalence, new infections, and AIDS mortality on a company, based on the anonymous HIV testing of company employees, and projections from the ASSA model. A smoothed statistical model of the prevalence test data is computed, and then the ASSA model projection for each category of employees is adjusted so that it matches the measured prevalence in the year of testing. FURTHER WORK: Further techniques that could be developed are microsimulation (representing individuals in the computer), scenario planning for testing strategies, and models for the business environment, such as models of entire sectors, and mapping of HIV prevalence in time and space, based on workplace and community data.

  1. Computer-Aided Template for Model Reuse, Development and Maintenance

    DEFF Research Database (Denmark)

    Fedorova, Marina; Sin, Gürkan; Gani, Rafiqul

    2014-01-01

    A template-based approach for model development is presented in this work. Based on a model decomposition technique, the computer-aided template concept has been developed. This concept is implemented as a software tool , which provides a user-friendly interface for following the workflow steps, ...

  2. Computer-Aided Communication Satellite System Analysis and Optimization.

    Science.gov (United States)

    Stagl, Thomas W.; And Others

    Various published computer programs for fixed/broadcast communication satellite system synthesis and optimization are discussed. The rationale for selecting General Dynamics/Convair's Satellite Telecommunication Analysis and Modeling Program (STAMP) in modified form to aid in the system costing and sensitivity analysis work in the Program on…

  3. Computer program aids dual reflector antenna system design

    Science.gov (United States)

    Firnett, P.; Gerritsen, R.; Jarvie, P.; Ludwig, A.

    1968-01-01

    Computer program aids in the design of maximum efficiency dual reflector antenna systems. It designs a shaped cassegrainian antenna which has nearly 100 percent efficiency, and accepts input parameters specifying an existing conventional antenna and produces as output the modifications necessary to conform to a shaped design.

  4. A Computer Aided System for Simulating Weld Metal Solidification Crack

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    A computer-aided system for simulating weld solidification crack has been developed by which a welding engineer can carry out the welding solidification crack simulation on the basis of a commercial finite element analysis software package. Its main functions include calculating the heat generations of the moving arc, mesh generation, calculating stress-strain distributions with element rebirth technique.

  5. Computer tomography-aided ventriculography and cisternography

    Energy Technology Data Exchange (ETDEWEB)

    Cernoch, Z.; Sercl, M.; Heger, L.; Parizek, J. (Karlova Univ., Hradec Kralove (Czechoslovakia). Lekarska Fakulta)

    1983-01-28

    Computer tomography was used in 42 patients for the exploration of ventricular and subarachnoidal spaces following intraventricular, lumbar or suboccipital injections of 3 to 5 ml Amipaque using the kind of manoeuvre to permit optimum filling of the region concerned. This type of CT ventriculo- or cisternography is a significant supplement to plain CT examination particularly because it supplies data on the causes of CSF passage blocks. Thus, in two female patients it proved possible to localize cysts in the 3rd ventricle, the density of which was no different from that of CSF. As regards benign stenoses of the aqueduct, it is likely to yield less information than conventional specific ventriculography. On the other hand, the technique gives perfect visualization of all possible communications between pathological intracranial cavities and the ventricular system. CT cisternography proved useful for the identification of small-size isodense growths in the region of the sella turcica, and brought convincing evidence of the causes of profuse liquorrhea by demonstrating the presence of nasal meningocele. It was also found helpful in the analysis of the craniocervical region, otherwise difficult to survey.

  6. Computer-Aided Design and Computer-Aided Manufacturing Hydroxyapatite/Epoxide Acrylate Maleic Compound Construction for Craniomaxillofacial Bone Defects.

    Science.gov (United States)

    Zhang, Lei; Shen, Shunyao; Yu, Hongbo; Shen, Steve Guofang; Wang, Xudong

    2015-07-01

    The aim of this study was to investigate the use of computer-aided design and computer-aided manufacturing hydroxyapatite (HA)/epoxide acrylate maleic (EAM) compound construction artificial implants for craniomaxillofacial bone defects. Computed tomography, computer-aided design/computer-aided manufacturing and three-dimensional reconstruction, as well as rapid prototyping were performed in 12 patients between 2008 and 2013. The customized HA/EAM compound artificial implants were manufactured through selective laser sintering using a rapid prototyping machine into the exact geometric shapes of the defect. The HA/EAM compound artificial implants were then implanted during surgical reconstruction. Color-coded superimpositions demonstrated the discrepancy between the virtual plan and achieved results using Geomagic Studio. As a result, the HA/EAM compound artificial bone implants were perfectly matched with the facial areas that needed reconstruction. The postoperative aesthetic and functional results were satisfactory. The color-coded superimpositions demonstrated good consistency between the virtual plan and achieved results. The three-dimensional maximum deviation is 2.12 ± 0.65  mm and the three-dimensional mean deviation is 0.27 ± 0.07  mm. No facial nerve weakness or pain was observed at the follow-up examinations. Only 1 implant had to be removed 2 months after the surgery owing to severe local infection. No other complication was noted during the follow-up period. In conclusion, computer-aided, individually fabricated HA/EAM compound construction artificial implant was a good craniomaxillofacial surgical technique that yielded improved aesthetic results and functional recovery after reconstruction.

  7. Possible Computer Vision Systems and Automated or Computer-Aided Edging and Trimming

    Science.gov (United States)

    Philip A. Araman

    1990-01-01

    This paper discusses research which is underway to help our industry reduce costs, increase product volume and value recovery, and market more accurately graded and described products. The research is part of a team effort to help the hardwood sawmill industry automate with computer vision systems, and computer-aided or computer controlled processing. This paper...

  8. Methodology for Benefit Analysis of CAD/CAM (Computer-Aided Design/Computer-Aided Manufacturing) in USN Shipyards.

    Science.gov (United States)

    1984-03-01

    benefits of CAD/CAR and of the next generation technology, CIDER . The CADOS study (Ref. 13] offers a method to measure the intangibles of CAD/CAR...methodology that measures both tangible and intangible benefits of present CAD technology. This method would be hard to extend to CIDER technology because of...D-Ri38 398 METHODOLOGY FOR BENEFIT ANALYSIS OF CAD/CAM / (COMPUTER-HIDED DESIGN/COMPUTER-AIDED MANUFACTURING) IN USN SHIPYARDS(U) NAVAL POSTGRADUATE

  9. Computer-Aided Modeling of Lipid Processing Technology

    DEFF Research Database (Denmark)

    Diaz Tovar, Carlos Axel

    2011-01-01

    are widely used for design, analysis, and optimization of processes in the chemical and petrochemical industries. These computer-aided tools have helped the chemical industry to evolve beyond commodities toward specialty chemicals and ‘consumer oriented chemicals based products’. Unfortunately...... this is not the case for the edible oil and biodiesel industries. The oleochemical industry lags behind the chemical industry in terms of thermophysical property modeling and development of computational tools suitable for the design/analysis, and optimization of lipid-related processes. The aim of this work has been...... increase along with growing interest in biofuels, the oleochemical industry faces in the upcoming years major challenges in terms of design and development of better products and more sustainable processes to make them. Computer-aided methods and tools for process synthesis, modeling and simulation...

  10. On computer-aided design of aerospace vehicles

    Science.gov (United States)

    Sobieszczanski, J. E.; Voigt, S. J.; Fulton, R. E.

    1974-01-01

    Digital computers are being used in many engineering activities to support design work. This paper provides an overview of some of this work as it relates to the design of aerospace vehicles. Discussions are given of some of the complexities of the design process which lead to large design costs and time. A number of important but disjointed computer capabilities have evolved over the years in analysis, optimization, and graphics, and such capabilities aid in addressing the problem of design complexity. Examples of existing computer-aided design (CAD) systems are given and trends for future CAD systems are indicated, as well as their relationship to pertinent data management technology. It is suggested that major gains in design capability will occur through continued development of CAD methodology and that these gains may be accelerated through a large focused effort.

  11. Method of Computer-aided Instruction in Situation Control Systems

    Directory of Open Access Journals (Sweden)

    Anatoliy O. Kargin

    2013-01-01

    Full Text Available The article considers the problem of computer-aided instruction in context-chain motivated situation control system of the complex technical system behavior. The conceptual and formal models of situation control with practical instruction are considered. Acquisition of new behavior knowledge is presented as structural changes in system memory in the form of situational agent set. Model and method of computer-aided instruction represent formalization, based on the nondistinct theories by physiologists and cognitive psychologists.The formal instruction model describes situation and reaction formation and dependence on different parameters, effecting education, such as the reinforcement value, time between the stimulus, action and the reinforcement. The change of the contextual link between situational elements when using is formalized.The examples and results of computer instruction experiments of the robot device “LEGO MINDSTORMS NXT”, equipped with ultrasonic distance, touch, light sensors.

  12. A Computer Aided Consultant System for Mammogram Diagnosis

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    A computer-aided consultant system for mammogram diagnosis is proposed in this paper based on mam-mogram segmentation as an image mining technique, to aid radiologistis in X-ray film interpretation. The generalarchitecture of the system is introduced first, followed by a discussion of mammogram segmentation using logic fil-ter, an analysis of the statistical data to the diagnostics with respect to different clinical information, and a brief in-troduction to a fuzzy decision making subsystem. Finally some experimental results are given.

  13. Evaluation of computer-aided detection and diagnosis systems.

    Science.gov (United States)

    Petrick, Nicholas; Sahiner, Berkman; Armato, Samuel G; Bert, Alberto; Correale, Loredana; Delsanto, Silvia; Freedman, Matthew T; Fryd, David; Gur, David; Hadjiiski, Lubomir; Huo, Zhimin; Jiang, Yulei; Morra, Lia; Paquerault, Sophie; Raykar, Vikas; Samuelson, Frank; Summers, Ronald M; Tourassi, Georgia; Yoshida, Hiroyuki; Zheng, Bin; Zhou, Chuan; Chan, Heang-Ping

    2013-08-01

    Computer-aided detection and diagnosis (CAD) systems are increasingly being used as an aid by clinicians for detection and interpretation of diseases. Computer-aided detection systems mark regions of an image that may reveal specific abnormalities and are used to alert clinicians to these regions during image interpretation. Computer-aided diagnosis systems provide an assessment of a disease using image-based information alone or in combination with other relevant diagnostic data and are used by clinicians as a decision support in developing their diagnoses. While CAD systems are commercially available, standardized approaches for evaluating and reporting their performance have not yet been fully formalized in the literature or in a standardization effort. This deficiency has led to difficulty in the comparison of CAD devices and in understanding how the reported performance might translate into clinical practice. To address these important issues, the American Association of Physicists in Medicine (AAPM) formed the Computer Aided Detection in Diagnostic Imaging Subcommittee (CADSC), in part, to develop recommendations on approaches for assessing CAD system performance. The purpose of this paper is to convey the opinions of the AAPM CADSC members and to stimulate the development of consensus approaches and "best practices" for evaluating CAD systems. Both the assessment of a standalone CAD system and the evaluation of the impact of CAD on end-users are discussed. It is hoped that awareness of these important evaluation elements and the CADSC recommendations will lead to further development of structured guidelines for CAD performance assessment. Proper assessment of CAD system performance is expected to increase the understanding of a CAD system's effectiveness and limitations, which is expected to stimulate further research and development efforts on CAD technologies, reduce problems due to improper use, and eventually improve the utility and efficacy of CAD in

  14. WIFI AIDED INTEGRITY IMPROVEMENT IN MEMS INS/GNSS INTEGRATION

    Institute of Scientific and Technical Information of China (English)

    刘华; 刘彤

    2013-01-01

    The reliability of global navigation satellite system (GNSS) positioning degrades when satellite signals are interfered .Such degradation is hard to be deteced by a micro-electro mechanical system (MEMS) based inertial system(INS)/GNSS ,integrating navigation system with a conventional Kalman filtering ,which results in poten-tial integrity problem of the system .Hence ,an algorithm combining wireless fidelity (WiFi) signal with a federa-ted Kalman filter (FKF) is proposed to identify the system integrity in dense urban navigation .The criterion of the system integrity detection is created followed by the derivation of the integrity coefficient .The field test shows that integrity changes can be captured by applying WiFi ,and the maximum positioning error is reduced by 67% without compensation of inertial sensors in integrity deterioration .

  15. Experimental computation with oscillatory integrals

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, David H.; Borwein, Jonathan M.

    2009-06-26

    A previous study by one of the present authors, together with D. Borwein and I. Leonard [8], studied the asymptotic behavior of the p-norm of the sinc function: sinc(x) = (sin x)/x and along the way looked at closed forms for integer values of p. In this study we address these integrals with the tools of experimental mathematics, namely by computing their numerical values to high precision, both as a challenge in itself, and also in an attempt to recognize the numerical values as closed-form constants. With this approach, we are able to reproduce several of the results of [8] and to find new results, both numeric and analytic, that go beyond the previous study.

  16. Computer aided die design: A new open-source methodology

    Science.gov (United States)

    Carneiro, Olga Sousa; Rajkumar, Ananth; Ferrás, Luís Lima; Fernandes, Célio; Sacramento, Alberto; Nóbrega, João Miguel

    2017-05-01

    In this work we present a detailed description of how to use open source based computer codes to aid the design of complex profile extrusion dies, aiming to improve its flow distribution. The work encompasses the description of the overall open-source die design methodology, the implementation of the energy conservation equation in an existing OpenFOAM® solver, which will be then capable of simulating the steady non-isothermal flow of an incompressible generalized Newtonian fluid, and two case studies to illustrate the capabilities and practical usefulness of the developed methodology. The results obtained with these case studies, used to solve real industrial problems, demonstrate that the computational design aid is an excellent alternative, from economical and technical points of view, to the experimental trial-and-error procedure commonly used in industry.

  17. Microstereolithography-based computer-aided manufacturing for tissue engineering.

    Science.gov (United States)

    Cho, Dong-Woo; Kang, Hyun-Wook

    2012-01-01

    Various solid freeform fabrication technologies have been introduced for constructing three-dimensional (3-D) freeform structures. Of these, microstereolithography (MSTL) technology performs the best in 3-D space because it not only has high resolution, but also fast fabrication speed. Using this technology, 3-D structures with mesoscale size and microscale resolution are achievable. Many researchers have been trying to apply this technology to tissue engineering to construct medically applicable scaffolds, which require a 3-D shape that fits a defect with a mesoscale size and microscale inner architecture for efficient regeneration of artificial tissue. This chapter introduces the principles of MSTL technology and representative systems. It includes fabrication and computer-aided design/computer-aided manufacturing (CAD/CAM) processes to show the automation process by which measurements from medical images are used to fabricate the required 3-D shape. Then, various tissue engineering applications based on MSTL are summarized.

  18. A computer-based aid for the design of a strategic organizational culture

    OpenAIRE

    1998-01-01

    This paper presents a theoretical framework for the alignment of organizational culture and strategy by integrating knowledge from diverse areas of organizational studies including strategic human resource management, organizational culture, and the specific design of human resource practices. It then describes a computer-based aid which offers practitioners a step by step guide for improving their competitive position through the development of a "strategic" culture. It is proposed that orga...

  19. Information and computer-aided system for structural materials

    Energy Technology Data Exchange (ETDEWEB)

    Nekrashevitch, Yu.G.; Nizametdinov, Sh.U.; Polkovnikov, A.V.; Rumjantzev, V.P.; Surina, O.N. (Engineering Physics Inst., Moscow (Russia)); Kalinin, G.M.; Sidorenkov, A.V.; Strebkov, Yu.S. (Research and Development Inst. of Power Engineering, Moscow (Russia))

    1992-09-01

    An information and computer-aided system for structural materials data has been developed to provide data for the fusion and fission reactor system design. It is designed for designers, industrial engineers, and material science specialists and provides a friendly interface in an interactive mode. The database for structural materials contains the master files: Chemical composition, physical, mechanical, corrosion, technological properties, regulatory and technical documentation. The system is implemented on a PC/AT running the PS /2 operating system. (orig.).

  20. Contributions on Computer Aided Manufacturing of Drill-Jig Bushings

    Directory of Open Access Journals (Sweden)

    Vasile Cojocaru

    2009-01-01

    Full Text Available The paper presents the steps for computer aided manufacturing (CAMof the bushings technological class parts: design of the part in CADsoftware; generation of the parametrical link with MSExcel files; extract of the useful information for the technological design (mass, volume, surfaces; setting of the CNC lathe and necessary tools; programming of the CNC code for manufacturing. Given the large variety of the bushingsshapes and dimensions, the application focused on the jig bushings used in drilling processes.

  1. Peer Feedback in Computer Aided College English Writing Instruction

    OpenAIRE

    Ma Zhuo

    2016-01-01

    This study is to examine the acceptability of peer feedback in computer aided college English writing instruction. For the whole writing procedure, subjects in language labs were to take preparation, writing and evaluation stages, undergoing three editions suggested by peer feedbacks. For the first time reading, peers would comment on such general scale as subject and content of drafts, and the second focuses on specific items, for example the morphological, lexical and syntactical aspects, e...

  2. CADEE: Computer-Aided Directed Evolution of Enzymes

    Science.gov (United States)

    Amrein, Beat Anton; Steffen-Munsberg, Fabian; Szeler, Ireneusz; Purg, Miha; Kamerlin, Shina Caroline Lynn

    2017-01-01

    The tremendous interest in enzymes as biocatalysts has led to extensive work in enzyme engineering, as well as associated methodology development. Here, a new framework for computer-aided directed evolution of enzymes (CADEE) is presented which allows a drastic reduction in the time necessary to prepare and analyze in silico semi-automated directed evolution of enzymes. A pedagogical example of the application of CADEE to a real biological system is also presented in order to illustrate the CADEE workflow. PMID:28250941

  3. Some new algorithms for computer aided assembly planning

    OpenAIRE

    Kunica, Zoran; Vranješ, Božo; Hrman, Miljenko

    2015-01-01

    The paper depicts some of the improved and newly implemented algorithms of the computer aided design (CAD) based system for the plan generation of automatic assembly (GPAS), relating to definitions of assembly sequence and paths, space structuring (layout) of the assembly process for bench assembly product orientation, connectivity, and treatment of identical parts in a product. In the approach, the parts of which are presented in the paper, the mechanical product to be assembled is, initiall...

  4. Technology transfer of the Computer-Aided Prototyping System (CAPS)

    OpenAIRE

    Cooke, Robert P.

    1996-01-01

    The inability of the Department of Defense (DOD) to accurately and completely specify requirements for hard real-time software systems has resulted in poor productivity, schedule overruns, and software that is unmaintainable and unreliable. The Computer-Aided Prototyping System (CAPS) provides a capability to quickly develop functional prototypes to verify feasibility of system requirements early in the software development process. It was built to help program managers and software engineers...

  5. The computer-aided design of rubber-metal products

    Directory of Open Access Journals (Sweden)

    Pavlo S. Shvets

    2015-12-01

    Full Text Available The important problem in design of rubber-metal products is the optimization of their mass without sacrificing of proportionality factor is in the limits of standard. Aim: The aim of this work is to improve the computer-aided systems by development and implementation of improved optimization method in rubber-metal CAD systems for designers based on the reverse optimization. Materials and Methods: The paper studies the matters of computer-aided structural design of technical composite products composed of anisotropic materials that are essentially different in properties. Results: The structure of CAD systems for designers solving the problems of such design is offered and the work principles of its subsystems are described. It is shown that complicated systems optimization in CAD systems must consider as restrictions the entitative connection between separate elements of these systems within the area of the optimizing arguments. Conclusions: The problem of the “reverse” optimization when objective functions are the connectivity area parameters is considered. In many cases, this allows receiving solutions that are more effective during the computer-aided design process. The developed CAD system for designers was used during the production of rubber-metal shock absorbers at the Odessa Rubber Technical Articles Plant. The positive technical and economic effect was obtained.

  6. On the convergence of nanotechnology and Big Data analysis for computer-aided diagnosis.

    Science.gov (United States)

    Rodrigues, Jose F; Paulovich, Fernando V; de Oliveira, Maria Cf; de Oliveira, Osvaldo N

    2016-04-01

    An overview is provided of the challenges involved in building computer-aided diagnosis systems capable of precise medical diagnostics based on integration and interpretation of data from different sources and formats. The availability of massive amounts of data and computational methods associated with the Big Data paradigm has brought hope that such systems may soon be available in routine clinical practices, which is not the case today. We focus on visual and machine learning analysis of medical data acquired with varied nanotech-based techniques and on methods for Big Data infrastructure. Because diagnosis is essentially a classification task, we address the machine learning techniques with supervised and unsupervised classification, making a critical assessment of the progress already made in the medical field and the prospects for the near future. We also advocate that successful computer-aided diagnosis requires a merge of methods and concepts from nanotechnology and Big Data analysis.

  7. Selecting and effectively using a computer aided software engineering tool

    Energy Technology Data Exchange (ETDEWEB)

    Kuhn, D.L.

    1989-01-01

    Software engineering is a science by which user requirements are translated into a quality software product. Computer Aided Software Engineering (CASE) is the scientific application of a set of tools and methods to a software which results in high-quality, defect-free, and maintainable software products. The Computer Systems Engineering (CSE) group of Separations Technology at the Savannah River Site has successfully used CASE tools to produce high-quality, reliable, and maintainable software products. This paper details the selection process CSE used to acquire a commonly available CASE product and how the CSE group effectively used this CASE tool to consistently produce quality software. 9 refs.

  8. Correction of facial and mandibular asymmetry using a computer aided design/computer aided manufacturing prefabricated titanium implant.

    Science.gov (United States)

    Watson, Jason; Hatamleh, Muhanad; Alwahadni, Ahed; Srinivasan, Dilip

    2014-05-01

    Patients with significant craniofacial asymmetry may have functional problems associated with their occlusion and aesthetic concerns related to the imbalance in soft and hard tissue profiles. This report details a case of facial asymmetry secondary to left mandible angle deficiency due to undergoing previous radiotherapy. We describe the correction of the bony deformity using computer aided design/computer aided manufacturing custom-made titanium onlay using novel direct metal laser sintering. The direct metal laser sintering onlay proved a very accurate operative fit and showed a good aesthetic correction of the bony defect with no reported complications postoperatively. It is a useful low-morbidity technique, and there is no resorption or associated donor-site complications.

  9. Project-Based Teaching-Learning Computer-Aided Engineering Tools

    Science.gov (United States)

    Simoes, J. A.; Relvas, C.; Moreira, R.

    2004-01-01

    Computer-aided design, computer-aided manufacturing, computer-aided analysis, reverse engineering and rapid prototyping are tools that play an important key role within product design. These are areas of technical knowledge that must be part of engineering and industrial design courses' curricula. This paper describes our teaching experience of…

  10. 25 CFR 502.7 - Electronic, computer or other technologic aid.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Electronic, computer or other technologic aid. 502.7... DEFINITIONS OF THIS CHAPTER § 502.7 Electronic, computer or other technologic aid. (a) Electronic, computer or other technologic aid means any machine or device that: (1) Assists a player or the playing of a...

  11. Computer Navigation-aided Resection of Sacral Chordomas

    Directory of Open Access Journals (Sweden)

    Yong-Kun Yang

    2016-01-01

    Full Text Available Background: Resection of sacral chordomas is challenging. The anatomy is complex, and there are often no bony landmarks to guide the resection. Achieving adequate surgical margins is, therefore, difficult, and the recurrence rate is high. Use of computer navigation may allow optimal preoperative planning and improve precision in tumor resection. The purpose of this study was to evaluate the safety and feasibility of computer navigation-aided resection of sacral chordomas. Methods: Between 2007 and 2013, a total of 26 patients with sacral chordoma underwent computer navigation-aided surgery were included and followed for a minimum of 18 months. There were 21 primary cases and 5 recurrent cases, with a mean age of 55.8 years old (range: 35-84 years old. Tumors were located above the level of the S3 neural foramen in 23 patients and below the level of the S3 neural foramen in 3 patients. Three-dimensional images were reconstructed with a computed tomography-based navigation system combined with the magnetic resonance images using the navigation software. Tumors were resected via a posterior approach assisted by the computer navigation. Mean follow-up was 38.6 months (range: 18-84 months. Results: Mean operative time was 307 min. Mean intraoperative blood loss was 3065 ml. For computer navigation, the mean registration deviation during surgery was 1.7 mm. There were 18 wide resections, 4 marginal resections, and 4 intralesional resections. All patients were alive at the final follow-up, with 2 (7.7% exhibiting tumor recurrence. The other 24 patients were tumor-free. The mean Musculoskeletal Tumor Society Score was 27.3 (range: 19-30. Conclusions: Computer-assisted navigation can be safely applied to the resection of the sacral chordomas, allowing execution of preoperative plans, and achieving good oncological outcomes. Nevertheless, this needs to be accomplished by surgeons with adequate experience and skill.

  12. Custom-Made Computer-Aided-Design/Computer-Aided-Manufacturing Biphasic Calcium-Phosphate Scaffold for Augmentation of an Atrophic Mandibular Anterior Ridge

    Directory of Open Access Journals (Sweden)

    Francesco Guido Mangano

    2015-01-01

    Full Text Available This report documents the clinical, radiographic, and histologic outcome of a custom-made computer-aided-design/computer-aided-manufactured (CAD/CAM scaffold used for the alveolar ridge augmentation of a severely atrophic anterior mandible. Computed tomographic (CT images of an atrophic anterior mandible were acquired and modified into a 3-dimensional (3D reconstruction model; this was transferred to a CAD program, where a custom-made scaffold was designed. CAM software generated a set of tool-paths for the manufacture of the scaffold on a computer-numerical-control milling machine into the exact shape of the 3D design. A custom-made scaffold was milled from a synthetic micromacroporous biphasic calcium phosphate (BCP block. The scaffold closely matched the shape of the defect: this helped to reduce the time for the surgery and contributed to good healing. One year later, newly formed and well-integrated bone was clinically available, and two implants (AnyRidge, MegaGen, Gyeongbuk, South Korea were placed. The histologic samples retrieved from the implant sites revealed compact mature bone undergoing remodelling, marrow spaces, and newly formed trabecular bone surrounded by residual BCP particles. This study demonstrates that custom-made scaffolds can be fabricated by combining CT scans and CAD/CAM techniques. Further studies on a larger sample of patients are needed to confirm these results.

  13. A-mode ultrasound-based registration in computer-aided surgery of the skull.

    Science.gov (United States)

    Amstutz, Christoph; Caversaccio, Marco; Kowal, Jens; Bächler, Richard; Nolte, Lutz-Peter; Häusler, Rudolf; Styner, Martin

    2003-12-01

    To evaluate the integration and accuracy of A (amplitude)-mode ultrasound-based surface matching for noninvasive registration of the head into a frameless computer-aided surgery system for otorhinology and skull base surgery. Experimental study and case series. Academic medical center. Twelve patients underwent anterior and paranasal skull base surgery with the routine use of a computer-aided surgery system. A computer-aided surgery system, based on an optoelectronic localizer, was used to track the skull and the surgical tools, including the A-mode ultrasound probe. The A-mode probe was a 10-MHz immersion transducer. An acoustic lens attached to the transducer focused the ultrasonic beam to a depth of 1 to 10 mm. Accuracy tests were performed for the ultrasound setup. Different surface point distributions were evaluated with respect to matching accuracy on a human cadaver skull specimen equipped with fiducial markers. The matching comparison was based on the fiducial registration error. For the clinical evaluation, the laboratory setup was transferred to the operating room. Noninvasive registration of the skull by using A-mode ultrasound in computer-aided surgery (practical and clinical measurements). The accuracy tests on the human skull specimen revealed that the mean +/- SD fiducial registration error was 1.00 +/- 0.19 mm in the best series for A-mode ultrasound surface matchings and was robust with respect to different sets of surface points. The mean +/- SD root mean square error from the 12 A-mode ultrasound matchings in the patient study was 0.49 +/- 0.20 mm. A-mode ultrasound surface matching can be used as a noninvasive and accurate registration procedure in computer-aided surgery of the head.

  14. HINT for Squint: A Computer Reliant Diagnostic Aid for Strabismus

    Science.gov (United States)

    Gieszl, Louis R.; Morris, Jacqueline; Guyton, David L.

    1983-01-01

    This paper provides an outline of methods used for the implementation of a computer reliant diagnostic aid in the medical specialty of Ophthalmology. Some problems have been associated with many previous diagnostic models. A careful review indicates that the most serious problems were: • inability to handle: - multiple diseases coexistent in the patient - partially described diseases - extraneous input symptoms - quantitative signs along with symptoms • inflexible and non-extendible prototype models • lack of inclusive physician-approved data banks The use of computer techniques developed for large scale wargaming has allowed the construction of an extendable prototype model. The hierarchical searching techniques used provided the necessary partial matching solution to the above set of computational problems. An active physician-analyst dialogue permitted the avoidance of the last problem, since the actual data and diagnostic logic was physician input.

  15. The Computer Aided Aircraft-design Package (CAAP)

    Science.gov (United States)

    Yalif, Guy U.

    1994-01-01

    The preliminary design of an aircraft is a complex, labor-intensive, and creative process. Since the 1970's, many computer programs have been written to help automate preliminary airplane design. Time and resource analyses have identified, 'a substantial decrease in project duration with the introduction of an automated design capability'. Proof-of-concept studies have been completed which establish 'a foundation for a computer-based airframe design capability', Unfortunately, today's design codes exist in many different languages on many, often expensive, hardware platforms. Through the use of a module-based system architecture, the Computer aided Aircraft-design Package (CAAP) will eventually bring together many of the most useful features of existing programs. Through the use of an expert system, it will add an additional feature that could be described as indispensable to entry level engineers and students: the incorporation of 'expert' knowledge into the automated design process.

  16. Computer-Aided Design System for CP Single-Screw Compressor

    Institute of Scientific and Technical Information of China (English)

    SHEN Jing-feng; YAO Fu-sheng

    2006-01-01

    To design various optimum parameters and simulate the working process of CP single-screw compressor,the Computer-Aided Design(CAD)system for the CP singlescrew compressor has been established.A new method based on computer graphics technology,database technology,object-oriented programming technology,and visual simulation technology has been adopted in this CAD system.The system has integrated solid modeling function with parameterization design function and animator simulation function based on analyzing the working principle of the CP single-screw compressor.The experimental results show fhat the CAD system for the CP single-screw compressor is practical and feasible.

  17. Computer Aided Interpretation Approach for Optical Tomographic Images

    CERN Document Server

    Klose, Christian D; Netz, Uwe; Beuthan, Juergen; Hielscher, Andreas H

    2010-01-01

    A computer-aided interpretation approach is proposed to detect rheumatic arthritis (RA) of human finger joints in optical tomographic images. The image interpretation method employs a multi-variate signal detection analysis aided by a machine learning classification algorithm, called Self-Organizing Mapping (SOM). Unlike in previous studies, this allows for combining multiple physical image parameters, such as minimum and maximum values of the absorption coefficient for identifying affected and not affected joints. Classification performances obtained by the proposed method were evaluated in terms of sensitivity, specificity, Youden index, and mutual information. Different methods (i.e., clinical diagnostics, ultrasound imaging, magnet resonance imaging and inspection of optical tomographic images), were used as "ground truth"-benchmarks to determine the performance of image interpretations. Using data from 100 finger joints, findings suggest that some parameter combinations lead to higher sensitivities while...

  18. Computer-Aided Vaccine Design: A Brief Report

    Directory of Open Access Journals (Sweden)

    R Ghasemi Khorasgani

    2012-09-01

    Full Text Available Background: Although the conventional vaccines have been instrumented in the incidence of many infectious diseases, the advances in genetic engineering and bioinformatics have provided the opportunity for developing improved and new vaccines.Methods: Reverse vaccinology was pioneered by a group of researchers investigating development of a vaccine against serogroup B Neisseria meningitidis. Reverse vaccinology analyzes the entire genome of a pathogen with the aid of computational programs to identify potentially antigenic extracellular proteins.Results: Using this method for Neisseria meningitidis genome analysis, 600 secretory or surface-exposed proteins were identified and, subsequently, 350 proteins were expressed and purified. Finally, seven proteins capable of activating the immune system against a range of strains were identified.Conclusion: Improved computational techniques are now able to provide researchers with high-confidence predictions for complex biological characteristics. This will herald a move to computer-aided biotechnology in which time-consuming and expensive large-scale experimental approaches are progressively replaced by functional bioinformatic investigations.

  19. Computer-Aided Experiment Planning toward Causal Discovery in Neuroscience.

    Science.gov (United States)

    Matiasz, Nicholas J; Wood, Justin; Wang, Wei; Silva, Alcino J; Hsu, William

    2017-01-01

    Computers help neuroscientists to analyze experimental results by automating the application of statistics; however, computer-aided experiment planning is far less common, due to a lack of similar quantitative formalisms for systematically assessing evidence and uncertainty. While ontologies and other Semantic Web resources help neuroscientists to assimilate required domain knowledge, experiment planning requires not only ontological but also epistemological (e.g., methodological) information regarding how knowledge was obtained. Here, we outline how epistemological principles and graphical representations of causality can be used to formalize experiment planning toward causal discovery. We outline two complementary approaches to experiment planning: one that quantifies evidence per the principles of convergence and consistency, and another that quantifies uncertainty using logical representations of constraints on causal structure. These approaches operationalize experiment planning as the search for an experiment that either maximizes evidence or minimizes uncertainty. Despite work in laboratory automation, humans must still plan experiments and will likely continue to do so for some time. There is thus a great need for experiment-planning frameworks that are not only amenable to machine computation but also useful as aids in human reasoning.

  20. Computer-Aided Experiment Planning toward Causal Discovery in Neuroscience

    Science.gov (United States)

    Matiasz, Nicholas J.; Wood, Justin; Wang, Wei; Silva, Alcino J.; Hsu, William

    2017-01-01

    Computers help neuroscientists to analyze experimental results by automating the application of statistics; however, computer-aided experiment planning is far less common, due to a lack of similar quantitative formalisms for systematically assessing evidence and uncertainty. While ontologies and other Semantic Web resources help neuroscientists to assimilate required domain knowledge, experiment planning requires not only ontological but also epistemological (e.g., methodological) information regarding how knowledge was obtained. Here, we outline how epistemological principles and graphical representations of causality can be used to formalize experiment planning toward causal discovery. We outline two complementary approaches to experiment planning: one that quantifies evidence per the principles of convergence and consistency, and another that quantifies uncertainty using logical representations of constraints on causal structure. These approaches operationalize experiment planning as the search for an experiment that either maximizes evidence or minimizes uncertainty. Despite work in laboratory automation, humans must still plan experiments and will likely continue to do so for some time. There is thus a great need for experiment-planning frameworks that are not only amenable to machine computation but also useful as aids in human reasoning. PMID:28243197

  1. [Computer-aided prescribing: from utopia to reality].

    Science.gov (United States)

    Suárez-Varela Ubeda, J; Beltrán Calvo, C; Molina López, T; Navarro Marín, P

    2005-05-31

    To determine whether the introduction of computer-aided prescribing helped reduce the administrative burden at primary care centers. Descriptive, cross-sectional design. Torreblanca Health Center in the province of Seville, southern Spain. From 29 October 2003 to the present a pilot project involving nine pharmacies in the basic health zone served by this health center has been running to evaluate computer-aided prescribing (the Receta XXI project) with real patients. All patients on the center's list of patients who came to the center for an administrative consultation to renew prescriptions for medications or supplies for long-term treatment. Total number of administrative visits per patient for patients who came to the center to renew prescriptions for long-term treatment, as recorded by the Diraya system (Historia Clinica Digital del Ciudadano, or Citizen's Digital Medical Record) during the period from February to July 2004. Total number of the same type of administrative visits recorded by the previous system (TASS) during the period from February to July 2003. The mean number of administrative visits per month during the period from February to July 2003 was 160, compared to a mean number of 64 visits during the period from February to July 2004. The reduction in the number of visits for prescription renewal was 60%. Introducing a system for computer-aided prescribing significantly reduced the number of administrative visits for prescription renewal for long-term treatment. This could help reduce the administrative burden considerably in primary care if the system were used in all centers.

  2. COMPUTER-AIDED BLOCK ASSEMBLY PROCESS PLANNING IN SHIPBUILD-ING BASED ON RULE-REASONING

    Institute of Scientific and Technical Information of China (English)

    ZHANG Zhiying; LI Zhen; JIANG Zhibin

    2008-01-01

    Computer-aided block assembly process planning based on rule-reasoning are developed in order to improve the assembly efficiency and implement the automated block assembly process planning generation in shipbuilding. First, weighted directed liaison graph (WDLG) is proposed to represent the model of block assembly process according to the characteristics of assembly relation, and edge list (EL) is used to describe assembly sequences. Shapes and assembly attributes of block parts are analyzed to determine the assembly position and matched parts of parts used frequently. Then, a series of assembly rules are generalized, and assembly sequences for block are obtained by means of rule reasoning. Final, a prototype system of computer-aided block assembly process planning is built. The system has been tested on actual block, and the results were found to be quite efficiency. Meanwhile, the fundament for the automation of block assembly process generation and integration with other systems is established.

  3. A computer-aided software-tool for sustainable process synthesis-intensification

    DEFF Research Database (Denmark)

    Kumar Tula, Anjan; Babi, Deenesh K.; Bottlaender, Jack

    2017-01-01

    and determine within the design space, the more sustainable processes. In this paper, an integrated computer-aided software-tool that searches the design space for hybrid/intensified more sustainable process options is presented. Embedded within the software architecture are process synthesis...... constraints while also matching the design targets, they are therefore more sustainable than the base case. The application of the software-tool to the production of biodiesel is presented, highlighting the main features of the computer-aided, multi-stage, multi-scale methods that are able to determine more......Currently, the process industry is moving towards the design of innovative, more sustainable processes that show improvements in both economic and environmental factors. The design space of unit operations that can be combined to generate process flowsheet alternatives considering known unit...

  4. Computer-Aided Chemical Product Design Framework: Design of High Performance and Environmentally Friendly Refrigerants

    DEFF Research Database (Denmark)

    Cignitti, Stefano; Zhang, Lei; Gani, Rafiqul

    a driving force for the industry to continuously seek novel refrigerants as current refrigerants risk phasing out due to environmental regulations. This trend has been seen since the Kyoto Protocol in 1997 and recently from the EU regulations from 2014, which will restrict the use of some known refrigerants...... properties and needs should carefully be selected for a given heat pump cycle to ensure that an optimum refrigerant is found? How can cycle performance and environmental criteria be integrated at the product design stage and not in post-design analysis? Computer-aided product design methods enable...... the possibility of designing novel molecules, mixtures and blends, such as refrigerants through a systematic framework (Cignitti et al., 2015; Yunus et al., 2014). In this presentation a computer-aided framework is presented for chemical product design through mathematical optimization. Here, molecules, mixtures...

  5. Computer Aided Design and Analysis of Separation Processes with Electrolyte Systems

    DEFF Research Database (Denmark)

    Takano, Kiyoteru; Gani, Rafiqul; Kolar, P.

    2000-01-01

    A methodology for computer aided design and analysis of separation processes involving electrolyte systems is presented. The methodology consists of three main parts. The thermodynamic part 'creates' the problem specific property model package, which is a collection of pure component and mixture...... property models. The design and analysis part generates process (flowsheet) alternatives, evaluates/analyses feasibility of separation and provides a visual operation path for the desired separation. The simulation part consists of a simulation/calculation engine that allows the screening and validation...... of process alternatives. For the simulation part, a general multi-purpose, multi-phase separation model has been developed and integrated to an existing computer aided system. Application of the design and analysis methodology is highlighted through two illustrative case studies, (C) 2000 Elsevier Science...

  6. Computer Aided Design and Analysis of Separation Processes with Electrolyte Systems

    DEFF Research Database (Denmark)

    A methodology for computer aided design and analysis of separation processes involving electrolyte systems is presented. The methodology consists of three main parts. The thermodynamic part "creates" the problem specific property model package, which is a collection of pure component and mixture...... property models. The design and analysis part generates process (flowsheet) alternatives, evaluates/analyses feasibility of separation and provides a visual operation path for the desired separation. The simulation part consists of a simulation/calculation engine that allows the screening and validation...... of process alternatives. For the simulation part, a general multi-purpose, multi-phase separation model has been developed and integrated to an existing computer aided system. Application of the design and analysis methodology is highlighted through two illustrative case studies....

  7. Computer Aided Design and Analysis of Separation Processes with Electrolyte Systems

    DEFF Research Database (Denmark)

    A methodology for computer aided design and analysis of separation processes involving electrolyte systems is presented. The methodology consists of three main parts. The thermodynamic part "creates" the problem specific property model package, which is a collection of pure component and mixture...... property models. The design and analysis part generates process (flowsheet) alternatives, evaluates/analyses feasibility of separation and provides a visual operation path for the desired separation. The simulation part consists of a simulation/calculation engine that allows the screening and validation...... of process alternatives. For the simulation part, a general multi-purpose, multi-phase separation model has been developed and integrated to an existing computer aided system. Application of the design and analysis methodology is highlighted through two illustrative case studies....

  8. CATIA Core Tools Computer Aided Three-Dimensional Interactive Application

    CERN Document Server

    Michaud, Michel

    2012-01-01

    CATIA Core Tools: Computer-Aided Three-Dimensional Interactive Application explains how to use the essential features of this cutting-edge solution for product design and innovation. The book begins with the basics, such as launching the software, configuring the settings, and managing files. Next, you'll learn about sketching, modeling, drafting, and visualization tools and techniques. Easy-to-follow instructions along with detailed illustrations and screenshots help you get started using several CATIA workbenches right away. Reverse engineering--a valuable product development skill--is also covered in this practical resource.

  9. Efficient Use of Preisach Hysteresis Model in Computer Aided Design

    Directory of Open Access Journals (Sweden)

    IONITA, V.

    2013-05-01

    Full Text Available The paper presents a practical detailed analysis regarding the use of the classical Preisach hysteresis model, covering all the steps, from measuring the necessary data for the model identification to the implementation in a software code for Computer Aided Design (CAD in Electrical Engineering. An efficient numerical method is proposed and the hysteresis modeling accuracy is tested on magnetic recording materials. The procedure includes the correction of the experimental data, which are used for the hysteresis model identification, taking into account the demagnetizing effect for the sample that is measured in an open-circuit device (a vibrating sample magnetometer.

  10. Computer-Aided Design Of Sheet-Material Parts

    Science.gov (United States)

    Gilbert, Jeffrey L.; Paternoster, Vincent Y.; Levitt, Maureen L.; Osterloh, Mark R.

    1991-01-01

    Computer-aided-design system partly automates tedious process of designing and guiding assembly of small pieces of flat sheet material into large surfaces that approximate smoothly curved surfaces having complicated three-dimensional shapes. Capability provides for flexibility enabling designer to assess quickly and easily effects of changes in design in making engineering compromises among various sizes and shapes. Saves time and money in both design and fabrication. Used in rocket-engine application and other applications requiring design of sheet-material parts.

  11. Technology computer aided design simulation for VLSI MOSFET

    CERN Document Server

    Sarkar, Chandan Kumar

    2013-01-01

    Responding to recent developments and a growing VLSI circuit manufacturing market, Technology Computer Aided Design: Simulation for VLSI MOSFET examines advanced MOSFET processes and devices through TCAD numerical simulations. The book provides a balanced summary of TCAD and MOSFET basic concepts, equations, physics, and new technologies related to TCAD and MOSFET. A firm grasp of these concepts allows for the design of better models, thus streamlining the design process, saving time and money. This book places emphasis on the importance of modeling and simulations of VLSI MOS transistors and

  12. CADEE: Computer-Aided Directed Evolution of Enzymes

    Directory of Open Access Journals (Sweden)

    Beat Anton Amrein

    2017-01-01

    Full Text Available The tremendous interest in enzymes as biocatalysts has led to extensive work in enzyme engineering, as well as associated methodology development. Here, a new framework for computer-aided directed evolution of enzymes (CADEE is presented which allows a drastic reduction in the time necessary to prepare and analyze in silico semi-automated directed evolution of enzymes. A pedagogical example of the application of CADEE to a real biological system is also presented in order to illustrate the CADEE workflow.

  13. SNL Mechanical Computer Aided Design (MCAD) guide 2007.

    Energy Technology Data Exchange (ETDEWEB)

    Moore, Brandon; Pollice, Stephanie L.; Martinez, Jack R.

    2007-12-01

    This document is considered a mechanical design best-practice guide to new and experienced designers alike. The contents consist of topics related to using Computer Aided Design (CAD) software, performing basic analyses, and using configuration management. The details specific to a particular topic have been leveraged against existing Product Realization Standard (PRS) and Technical Business Practice (TBP) requirements while maintaining alignment with sound engineering and design practices. This document is to be considered dynamic in that subsequent updates will be reflected in the main title, and each update will be published on an annual basis.

  14. CATIA - A computer aided design and manufacturing tridimensional system

    Science.gov (United States)

    Bernard, F.

    A properietary computer graphics-aided, three-dimensional interactive application (CATIA) design system is described. CATIA employs approximately 100 graphics displays, which are used by some 500 persons engaged in the definition of aircraft structures, structural strength analyses, the kinematic analysis of mobile elements, aerodynamic calculations, the choice of tooling in the machining of aircraft elements, and the programming of robotics. CATIA covers these diverse fields with a single data base. After a description of salient aspects of the system's hardware and software, graphics examples are given of the definition of curves, surfaces, complex volumes, and analytical tasks.

  15. 9th Asian Conference on Computer-Aided Surgery

    CERN Document Server

    2016-01-01

    This book presents the latest research advances in the theory, design, control, and application of robot systems intended for a variety of purposes such as manipulation, manufacturing, automation, surgery, locomotion, and biomechanics. Several chapters deal with fundamental kinematics in nature, including synthesis, calibration, redundancy, force control, dexterity, inverse and forward kinematics, kinematic singularities, and over-constrained systems. This book is a compilation of the extended versions of the very best papers selected from the many that were presented at the Asian Conference on Computer-Aided Surgery held September 16–18, 2013, in Tokyo, Japan (ACCAS 2013).

  16. Computer Aided Study of Mechanism of Immunoadsorbent for Myasthenia Gravis

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Myasthenia Gravis (MG) is an organ specific autoimmune disease mediated by autoantibodies (AChR Ab) against the acetylcholine receptor (AChR). Literature reported that the AChR Ab can be removed by absorbent linked with tryptophan. It was studied in detail in our lab. With the aid of computer, we docked some ligands into AChR Ab, and the results from scores of docking under different generations showed that there was no specific binding between tryptophan and scFv fragment just as the binding between antigen-antibody. The interaction between Trp and immunoglobulin was a broad-spectrum binding.

  17. Retrospective indexing (RI) - A computer-aided indexing technique

    Science.gov (United States)

    Buchan, Ronald L.

    1990-01-01

    An account is given of a method for data base-updating designated 'computer-aided indexing' (CAI) which has been very efficiently implemented at NASA's Scientific and Technical Information Facility by means of retrospective indexing. Novel terms added to the NASA Thesaurus will therefore proceed directly into both the NASA-RECON aerospace information system and its portion of the ESA-Information Retrieval Service, giving users full access to material thus indexed. If a given term appears in the title of a record, it is given special weight. An illustrative graphic representation of the CAI search strategy is presented.

  18. A comparative study of two computer-aided measurement methods

    OpenAIRE

    Gronau, Franziska

    2010-01-01

    Growth and developmental disorders of the elbow joint are frequent causes of lameness of the thoracic limb of the dog. Golden Retriever is one of the mainly affected breeds. Two different computer-aided methods of measurement will be compared in this study. The aim is to find out whether one of these measurement methods is more suitable to distinguish affected from unaffected joints and to recognize a possible predisposition for elbow dysplasia (ED). X-Rays of the elbow joints in the medio-la...

  19. Using HIV&AIDS statistics in pre-service Mathematics Education to integrate HIV&AIDS education.

    Science.gov (United States)

    van Laren, Linda

    2012-12-01

    In South Africa, the HIV&AIDS education policy documents indicate opportunities for integration across disciplines/subjects. There are different interpretations of integration/inclusion and mainstreaming HIV&AIDS education, and numerous levels of integration. Integration ensures that learners experience the disciplines/subjects as being linked and related, and integration is required to support and expand the learners' opportunities to attain skills, acquire knowledge and develop attitudes and values across the curriculum. This study makes use of self-study methodology where I, a teacher educator, aim to improve my practice through including HIV&AIDS statistics in Mathematics Education. This article focuses on how I used HIV&AIDS statistics to facilitate pre-service teacher reflection and introduce them to integration of HIV&AIDS education across the curriculum. After pre-service teachers were provided with HIV statistics, they drew a pie chart which graphically illustrated the situation and reflected on issues relating to HIV&AIDS. Three themes emerged from the analysis of their reflections. The themes relate to the need for further HIV&AIDS education, the changing pastoral role of teachers and the changing context of teaching. This information indicates that the use of statistics is an appropriate means of initiating the integration of HIV&AIDS education into the academic curriculum.

  20. Posterior moments computed by mixed integration

    NARCIS (Netherlands)

    H.K. van Dijk (Herman); T. Kloek (Teun); C.G.E. Boender

    1985-01-01

    textabstractA flexible numerical integration method is proposed for the computation of moments of a multivariate posterior density with different tail properties in different directions. The method (called mixed integration) amounts to a combination of classical numerical integration and Monte Carlo

  1. Computer-Aided Numerical Inversion of Laplace Transform

    Directory of Open Access Journals (Sweden)

    Umesh Kumar

    2000-01-01

    Full Text Available This paper explores the technique for the computer aided numerical inversion of Laplace transform. The inversion technique is based on the properties of a family of three parameter exponential probability density functions. The only limitation in the technique is the word length of the computer being used. The Laplace transform has been used extensively in the frequency domain solution of linear, lumped time invariant networks but its application to the time domain has been limited, mainly because of the difficulty in finding the necessary poles and residues. The numerical inversion technique mentioned above does away with the poles and residues but uses precomputed numbers to find the time response. This technique is applicable to the solution of partially differentiable equations and certain classes of linear systems with time varying components.

  2. Computer-aided conceptual design of Air Cushion Vehicles

    Science.gov (United States)

    Band, E. G. U.; Lavis, D. R.

    This paper describes the development and use of a computer-aided design tool which has been used to explore preferred options for amphibious Air-Cushion Vehicle (ACV) and Surface-Effect Ship (SES) designs in support of U.S. Navy and U.S. Army programs. The tool, referred to as the ACV Design Synthesis Model (ADSM), is an interactive computer program which provides a description of feasible ACV or SES concepts that could be developed, by a competent design team, to perform the mission described by the input parameters. The paper discusses how the program was used to explore parametrically the design of a range of self-propelled hoverbarges to meet requirements of the U.S. Army Logistics Over the Shore (LOTS) phases of an amphibious landing. Examples of results are presented to illustrate the method used in determining design and performance trade-offs.

  3. Computer aided systems human engineering: A hypermedia tool

    Science.gov (United States)

    Boff, Kenneth R.; Monk, Donald L.; Cody, William J.

    1992-01-01

    The Computer Aided Systems Human Engineering (CASHE) system, Version 1.0, is a multimedia ergonomics database on CD-ROM for the Apple Macintosh II computer, being developed for use by human system designers, educators, and researchers. It will initially be available on CD-ROM and will allow users to access ergonomics data and models stored electronically as text, graphics, and audio. The CASHE CD-ROM, Version 1.0 will contain the Boff and Lincoln (1988) Engineering Data Compendium, MIL-STD-1472D and a unique, interactive simulation capability, the Perception and Performance Prototyper. Its features also include a specialized data retrieval, scaling, and analysis capability and the state of the art in information retrieval, browsing, and navigation.

  4. Shape Signatures: speeding up computer aided drug discovery.

    Science.gov (United States)

    Meek, Peter J; Liu, ZhiWei; Tian, LiFeng; Wang, Ching Y; Welsh, William J; Zauhar, Randy J

    2006-10-01

    Identifying potential lead molecules is becoming a more automated process. We review Shape Signatures, a tool that is effective and easy to use compared with most computer aided drug design techniques. Laboratory researchers can apply this in silico technique cost-effectively without the need for specialized computer backgrounds. Identifying a potential lead molecule requires database screening, and this becomes rate-limiting once the database becomes too large. The use of Shape Signatures eliminates this concern and offers molecule screening rates that are in advance of any currently available method. Shape Signatures provides a conduit for researchers to conduct rapid identification of potential active molecules, and studies with this tool can be initiated with only one bioactive lead or receptor site.

  5. A Computer-Aided Detection System for Digital Chest Radiographs

    Directory of Open Access Journals (Sweden)

    Juan Manuel Carrillo-de-Gea

    2016-01-01

    Full Text Available Computer-aided detection systems aim at the automatic detection of diseases using different medical imaging modalities. In this paper, a novel approach to detecting normality/pathology in digital chest radiographs is proposed. The problem tackled is complicated since it is not focused on particular diseases but anything that differs from what is considered as normality. First, the areas of interest of the chest are found using template matching on the images. Then, a texture descriptor called local binary patterns (LBP is computed for those areas. After that, LBP histograms are applied in a classifier algorithm, which produces the final normality/pathology decision. Our experimental results show the feasibility of the proposal, with success rates above 87% in the best cases. Moreover, our technique is able to locate the possible areas of pathology in nonnormal radiographs. Strengths and limitations of the proposed approach are described in the Conclusions.

  6. Computer aided analysis, simulation and optimisation of thermal sterilisation processes.

    Science.gov (United States)

    Narayanan, C M; Banerjee, Arindam

    2013-04-01

    Although thermal sterilisation is a widely employed industrial process, little work is reported in the available literature including patents on the mathematical analysis and simulation of these processes. In the present work, software packages have been developed for computer aided optimum design of thermal sterilisation processes. Systems involving steam sparging, jacketed heating/cooling, helical coils submerged in agitated vessels and systems that employ external heat exchangers (double pipe, shell and tube and plate exchangers) have been considered. Both batch and continuous operations have been analysed and simulated. The dependence of del factor on system / operating parameters such as mass or volume of substrate to be sterilised per batch, speed of agitation, helix diameter, substrate to steam ratio, rate of substrate circulation through heat exchanger and that through holding tube have been analysed separately for each mode of sterilisation. Axial dispersion in the holding tube has also been adequately accounted for through an appropriately defined axial dispersion coefficient. The effect of exchanger characteristics/specifications on the system performance has also been analysed. The multiparameter computer aided design (CAD) software packages prepared are thus highly versatile in nature and they permit to make the most optimum choice of operating variables for the processes selected. The computed results have been compared with extensive data collected from a number of industries (distilleries, food processing and pharmaceutical industries) and pilot plants and satisfactory agreement has been observed between the two, thereby ascertaining the accuracy of the CAD softwares developed. No simplifying assumptions have been made during the analysis and the design of associated heating / cooling equipment has been performed utilising the most updated design correlations and computer softwares.

  7. Computer-aided ultrasonic inspection of steam turbine rotors

    Energy Technology Data Exchange (ETDEWEB)

    Mayer, K.H.; Weber, M.; Weiss, M. [GEC ALSTHOM Energie GmbH, Nuremberg (Germany)

    1998-12-31

    As the output and economic value of power plants increase, the detection and sizing of the type of flaws liable to occur in the rotors of turbines using ultrasonic methods assumes increasing importance. An ultrasonic inspection carried out at considerable expense is expected to bring to light all safety-relevant flaws and to enable their size to be determined so as to permit a fracture-mechanics analysis to assess the reliability of the rotor under all possible stresses arising in operation with a high degree of accuracy. The advanced computer-aided ultrasonic inspection of steam turbine rotors have improved reliability, accuracy and reproducibility of ultrasonic inspection. Further, there has been an improvement in the resolution of resolvable group indications by applying reconstruction and imagine methods. In general, it is also true for the advanced computer-aided ultrasonic inspection methods that, in the case of flaw-affected forgings, automated data acquisition provides a substantial rationalization and a significant documentation of the results for the fracture mechanics assessment compared to manual inspection. (orig.) 8 refs.

  8. NALDA (Naval Aviation Logistics Data Analysis) CAI (computer aided instruction)

    Energy Technology Data Exchange (ETDEWEB)

    Handler, B.H. (Oak Ridge K-25 Site, TN (USA)); France, P.A.; Frey, S.C.; Gaubas, N.F.; Hyland, K.J.; Lindsey, A.M.; Manley, D.O. (Oak Ridge Associated Universities, Inc., TN (USA)); Hunnum, W.H. (North Carolina Univ., Chapel Hill, NC (USA)); Smith, D.L. (Memphis State Univ., TN (USA))

    1990-07-01

    Data Systems Engineering Organization (DSEO) personnel developed a prototype computer aided instruction CAI system for the Naval Aviation Logistics Data Analysis (NALDA) system. The objective of this project was to provide a CAI prototype that could be used as an enhancement to existing NALDA training. The CAI prototype project was performed in phases. The task undertaken in Phase I was to analyze the problem and the alternative solutions and to develop a set of recommendations on how best to proceed. The findings from Phase I are documented in Recommended CAI Approach for the NALDA System (Duncan et al., 1987). In Phase II, a structured design and specifications were developed, and a prototype CAI system was created. A report, NALDA CAI Prototype: Phase II Final Report, was written to record the findings and results of Phase II. NALDA CAI: Recommendations for an Advanced Instructional Model, is comprised of related papers encompassing research on computer aided instruction CAI, newly developing training technologies, instructional systems development, and an Advanced Instructional Model. These topics were selected because of their relevancy to the CAI needs of NALDA. These papers provide general background information on various aspects of CAI and give a broad overview of new technologies and their impact on the future design and development of training programs. The paper within have been index separately elsewhere.

  9. Assessment technique for computer-aided manufactured sockets

    Directory of Open Access Journals (Sweden)

    Joan E. Sanders, PhD

    2011-08-01

    Full Text Available This article presents an assessment technique for testing the quality of prosthetic socket fabrication processes at computer-aided manufacturing facilities. The assessment technique is potentially useful to both facilities making sockets and companies marketing manufacturing equipment seeking to assess and improve product quality. To execute the assessment technique, an evaluator fabricates a collection of test models and sockets using the manufacturing suite under evaluation, then measures their shapes using scanning equipment. Overall socket quality is assessed by comparing socket shapes with electronic file (e-file shapes. To characterize carving performance, model shapes are compared with e-file shapes. To characterize forming performance, socket shapes are compared with model shapes. The mean radial error (MRE, which is the average difference in radii between the two compared shapes, provides insight into sizing quality. Interquartile range (IQR, the range of radial error for the best-matched half of the points on the compared socket surfaces, provides insight into regional shape quality. The source(s of socket shape error may be pinpointed by separately determining MRE and IQR for carving and forming. The developed assessment technique may provide a useful tool to the prosthetics community and industry to help identify problems and limitations in computer-aided manufacturing and give insight into appropriate modifications to overcome them.

  10. Computer-aided morphometry of liver inflammation in needle biopsies

    Institute of Scientific and Technical Information of China (English)

    N Dioguardi; B Franceschini; C Russo; F Grizzi

    2005-01-01

    AIM: To introduce a computer-aided morphometric method for quantifying the necro-inflammatory phase in liver biopsy specimens using fractal geometry and Delaunay's triangulation.METHODS: Two-micrometer thick biopsy sections taken from 78 chronic hepatitis C virus-infected patients were immunohistochemically treated to identify the inflammatory cells. An automatic computer-aided image analysis system was used to define the inflammatory cell network defined on the basis of Delaunay's triangulation,and the inflammatory cells were geometrically classified as forming a cluster (an aggregation of a minimum of three cells) or as being irregularly distributed within the tissue. The phase of inflammatory activity was estimated using Hurst's exponent.RESULTS: The proposed automatic method was rapid and objective. It could not only provide rigorous results expressed by scalar numbers, but also allow the state of the whole organ to be represented by Hurst's exponent with an error of no more than 12%.CONCLUSION: The availability of rigorous metrical measures and the reasonable representativeness of the status of the organ as a whole raise the question as to whether the indication for hepatic biopsy should be revised by establishing clear rules concerning the contraindications suggested by its invasiveness and subjective interpretation.

  11. Computer-aided dermoscopy for diagnosis of melanoma

    Directory of Open Access Journals (Sweden)

    Naraghi Zahra S

    2005-07-01

    Full Text Available Abstract Background Computer-aided dermoscopy using artificial neural networks has been reported to be an accurate tool for the evaluation of pigmented skin lesions. We set out to determine the sensitivity and specificity of a computer-aided dermoscopy system for diagnosis of melanoma in Iranian patients. Methods We studied 122 pigmented skin lesions which were referred for diagnostic evaluation or cosmetic reasons. Each lesion was examined by two clinicians with naked eyes and all of their clinical diagnostic considerations were recorded. The lesions were analyzed using a microDERM® dermoscopy unit. The output value of the software for each lesion was a score between 0 and 10. All of the lesions were excised and examined histologically. Results Histopathological examination revealed melanoma in six lesions. Considering only the most likely clinical diagnosis, sensitivity and specificity of clinical examination for diagnosis of melanoma were 83% and 96%, respectively. Considering all clinical diagnostic considerations, the sensitivity and specificity were 100% and 89%. Choosing a cut-off point of 7.88 for dermoscopy score, the sensitivity and specificity of the score for diagnosis of melanoma were 83% and 96%, respectively. Setting the cut-off point at 7.34, the sensitivity and specificity were 100% and 90%. Conclusion The diagnostic accuracy of the dermoscopy system was at the level of clinical examination by dermatologists with naked eyes. This system may represent a useful tool for screening of melanoma, particularly at centers not experienced in the field of pigmented skin lesions.

  12. Computer Aided Phenomenography: The Role of Leximancer Computer Software in Phenomenographic Investigation

    Science.gov (United States)

    Penn-Edwards, Sorrel

    2010-01-01

    The qualitative research methodology of phenomenography has traditionally required a manual sorting and analysis of interview data. In this paper I explore a potential means of streamlining this procedure by considering a computer aided process not previously reported upon. Two methods of lexicological analysis, manual and automatic, were examined…

  13. Computer-Aided Training and Quality Assessment of Creative Abilities

    Directory of Open Access Journals (Sweden)

    V. P. Pechnikov

    2015-01-01

    Full Text Available The article describes the training program that takes into account the laws of human mental activity. The peculiarity of this training is that it enables specialists to generate additional intellectual potentials. This potentials relate to various kinds of illogical (intuitive and hybrid (human-machine intelligences that are associated with the quality of professional and creative activity in future. Progress in trans-phenomenal functional systems of the brain is possible by means of special procedures and computer-based training programs.The article offers a logical system of computer-aided training. This system repeatedly compares its input and output data and uses a feedback as the innate human characteristic to obtain the final result.Computer-aided training can be implemented in analog and numeric form. The article deals with the numeric widely used MS Excel-based software. It provides tabular and graphic style visualization desirable for training.A specific technical program is used for training. It allows specialists to develop a reinforcement shell of square cell type of minimal weight. In designing various constraints can be considered.On the main page of MS Excel program there are input data tables, various forms of the cell, methods of its manufacturing, and a scale table. Coefficients needed for calculations are in the next tables. The next tables contain also technological and design limitations. The basic table enables us to vary the geometric complexes of the reinforcement shell. Using the tabular and graphical results of calculations an operator can define values of further steps (iterations. The operator’s aim is to design the shell of minimum weight for the shortest time or number of steps. There is number of counters using macros in the MS Excel tables to calculate the number of past iterations.

  14. A Computer Aided Detection system for mammographic images implemented on a GRID infrastructure

    CERN Document Server

    Bottigli, U; Delogu, P; Fantacci, M E; Fauci, F; Forni, G; Golosio, B; Indovina, P L; Lauria, A; Magro, R; Masala, G L; Oliva, P R; Palmiero, R; Raso, G; Retico, A; Stefanini, A; Stumbo, S; Tangaro, S; Torres, E L

    2003-01-01

    The use of an automatic system for the analysis of mammographic images has proven to be very useful to radiologists in the investigation of breast cancer, especially in the framework of mammographic-screening programs. A breast neoplasia is often marked by the presence of microcalcification clusters and massive lesions in the mammogram: hence the need for tools able to recognize such lesions at an early stage. In the framework of the GPCALMA (GRID Platform for Computer Assisted Library for MAmmography) project, the co-working of italian physicists and radiologists built a large distributed database of digitized mammographic images (about 5500 images corresponding to 1650 patients) and developed a CAD (Computer Aided Detection) system, able to make an automatic search of massive lesions and microcalcification clusters. The CAD is implemented in the GPCALMA integrated station, which can be used also for digitization, as archive and to perform statistical analyses. Some GPCALMA integrated stations have already b...

  15. Computer graphics application in the engineering design integration system

    Science.gov (United States)

    Glatt, C. R.; Abel, R. W.; Hirsch, G. N.; Alford, G. E.; Colquitt, W. N.; Stewart, W. A.

    1975-01-01

    The computer graphics aspect of the Engineering Design Integration (EDIN) system and its application to design problems were discussed. Three basic types of computer graphics may be used with the EDIN system for the evaluation of aerospace vehicles preliminary designs: offline graphics systems using vellum-inking or photographic processes, online graphics systems characterized by direct coupled low cost storage tube terminals with limited interactive capabilities, and a minicomputer based refresh terminal offering highly interactive capabilities. The offline line systems are characterized by high quality (resolution better than 0.254 mm) and slow turnaround (one to four days). The online systems are characterized by low cost, instant visualization of the computer results, slow line speed (300 BAUD), poor hard copy, and the early limitations on vector graphic input capabilities. The recent acquisition of the Adage 330 Graphic Display system has greatly enhanced the potential for interactive computer aided design.

  16. Orthodontics: computer-aided diagnosis and treatment planning

    Science.gov (United States)

    Yi, Yaxing; Li, Zhongke; Wei, Suyuan; Deng, Fanglin; Yao, Sen

    2000-10-01

    The purpose of this article is to introduce the outline of our newly developed computer-aided 3D dental cast analyzing system with laser scanning, and its preliminary clinical applications. The system is composed of a scanning device and a personal computer as a scanning controller and post processor. The scanning device is composed of a laser beam emitter, two sets of linear CCD cameras and a table which is rotatable by two-degree-of-freedom. The rotating is controlled precisely by a personal computer. The dental cast is projected and scanned with a laser beam. Triangulation is applied to determine the location of each point. Generation of 3D graphics of the dental cast takes approximately 40 minutes. About 170,000 sets of X,Y,Z coordinates are store for one dental cast. Besides the conventional linear and angular measurements of the dental cast, we are also able to demonstrate the size of the top surface area of each molar. The advantage of this system is that it facilitates the otherwise complicated and time- consuming mock surgery necessary for treatment planning in orthognathic surgery.

  17. Computer-aided classification of melanocytic lesions using dermoscopic images.

    Science.gov (United States)

    Ferris, Laura K; Harkes, Jan A; Gilbert, Benjamin; Winger, Daniel G; Golubets, Kseniya; Akilov, Oleg; Satyanarayanan, Mahadev

    2015-11-01

    Computer-assisted diagnosis of dermoscopic images of skin lesions has the potential to improve melanoma early detection. We sought to evaluate the performance of a novel classifier that uses decision forest classification of dermoscopic images to generate a lesion severity score. Severity scores were calculated for 173 dermoscopic images of skin lesions with known histologic diagnosis (39 melanomas, 14 nonmelanoma skin cancers, and 120 benign lesions). A threshold score was used to measure classifier sensitivity and specificity. A reader study was conducted to compare the sensitivity and specificity of the classifier with those of 30 dermatology clinicians. The classifier sensitivity for melanoma was 97.4%; specificity was 44.2% in a test set of images. In the reader study, the classifier's sensitivity to melanoma was higher (P classifier may aid clinicians in deciding if a skin lesion should be biopsied and can easily be incorporated into a portable tool (that uses no proprietary equipment) that could aid clinicians in noninvasively evaluating cutaneous lesions. Copyright © 2015. Published by Elsevier Inc.

  18. XPLANE, a Generative Computer Aided Process Planning System for Part Manufacturing

    NARCIS (Netherlands)

    Erve, van 't A.H.

    1986-01-01

    This paper reports on the development of XPLANE, a generative computer aided process planning system for part manufacturing. Described is its position and functioning as a part of a more extended computer aided manufacturing system that includes a link to CAD systems, as well as systems for computer

  19. Computer-aided diagnosis in chest radiography: Beyond nodules

    Energy Technology Data Exchange (ETDEWEB)

    Ginneken, Bram van [University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht (Netherlands)], E-mail: bram@isi.uu.nl; Hogeweg, Laurens; Prokop, Mathias [University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht (Netherlands)

    2009-11-15

    Chest radiographs are the most common exam in radiology. They are essential for the management of various diseases associated with high mortality and morbidity and display a wide range of findings, many of them subtle. In this survey we identify a number of areas beyond pulmonary nodules that could benefit from computer-aided detection and diagnosis (CAD) in chest radiography. These include interstitial infiltrates, catheter tip detection, size measurements, detection of pneumothorax and detection and quantification of emphysema. Recent work in these areas is surveyed, but we conclude that the amount of research devoted to these topics is modest. Reasons for the slow pace of CAD development in chest radiography beyond nodules are discussed.

  20. 13th International Conference on Computer Aided Engineering

    CERN Document Server

    Pietrusiak, Damian

    2017-01-01

    These proceedings of the 13th International Conference on Computer Aided Engineering present selected papers from the event, which was held in Polanica Zdrój, Poland, from June 22 to 25, 2016. The contributions are organized according to thematic sections on the design and manufacture of machines and technical systems; durability prediction; repairs and retrofitting of power equipment; strength and thermodynamic analyses for power equipment; design and calculation of various types of load-carrying structures; numerical methods for dimensioning materials handling; and long-distance transport equipment. The conference and its proceedings offer a major interdisciplinary forum for researchers and engineers to present the most innovative studies and advances in this dynamic field.

  1. Computer aided microbial safety design of food processes.

    Science.gov (United States)

    Schellekens, M; Martens, T; Roberts, T A; Mackey, B M; Nicolaï, B M; Van Impe, J F; De Baerdemaeker, J

    1994-12-01

    To reduce the time required for product development, to avoid expensive experimental tests, and to quantify safety risks for fresh products and the consequence of processing there is a growing interest in computer aided food process design. This paper discusses the application of hybrid object-oriented and rule-based expert system technology to represent the data and knowledge of microbial experts and food engineers. Finite element models for heat transfer calculation routines, microbial growth and inactivation models and texture kinetics are combined with food composition data, thermophysical properties, process steps and expert knowledge on type and quantity of microbial contamination. A prototype system has been developed to evaluate changes in food composition, process steps and process parameters on microbiological safety and textual quality of foods.

  2. Systematic Computer-Aided Framework for Sustainable Chemical Product Design

    DEFF Research Database (Denmark)

    Cignitti, Stefano; Zhang, Lei; Kalakul, Sawitree

    Computer-aided product design (CAPD) is a method for the generation and selection of novel pure, mixed and blended chemical products [1]. In CAPD, the chemical product is generated and selected based on defined structure, property and process/application constraints. Several challenges exist...... for CAPD, including the accuracy of the property estimation, molecular structure generation, inclusion of sustainability, process and application targets and needs in the problem formulation. CAPD has been widely utilized for the synthesis of several types of products, such as solvents, polymers, fuels...... and formulated products [2]. However, for product design problems where the process needs and sustainability possess demanding constraints, the complexity of the problem is increased as the relation between product property, sustainability and process criteria is difficult to mathematically define. In this work...

  3. Computer- Aided Design in Power Engineering Application of Software Tools

    CERN Document Server

    Stojkovic, Zlatan

    2012-01-01

    This textbooks demonstrates the application of software tools in solving a series of problems from the field of designing power system structures and systems. It contains four chapters: The first chapter leads the reader through all the phases necessary in the procedures of computer aided modeling and simulation. It guides through the complex problems presenting on the basis of eleven original examples. The second chapter presents  application of software tools in power system calculations of power systems equipment design. Several design example calculations are carried out using engineering standards like MATLAB, EMTP/ATP, Excel & Access, AutoCAD and Simulink. The third chapters focuses on the graphical documentation using a collection of software tools (AutoCAD, EPLAN, SIMARIS SIVACON, SIMARIS DESIGN) which enable the complete automation of the development of graphical documentation of a power systems. In the fourth chapter, the application of software tools in the project management in power systems ...

  4. Computer aided planning and navigation for orbito-zygomatic reconstruction

    CERN Document Server

    Marecaux, Christophe; Payan, Yohan; Boutault, Franck

    2007-01-01

    This paper suggests a full protocol of Computer Aided Surgery as previously recommended in literature addressing the challenging task of primary or secondary reconstruction of orbito-zygomatic dislocation. First, on a specifically developed planning software, the best zygoma reduction and orbital boundaries reconstruction to achieve skeletal symmetry are determined. This treatment plan is then transferred to the 3D Navigation Systems within the operating room. After patient's anatomy registration to his preoperative CT scan data, the navigation system allows zygomatic guiding to its planned reduced location and bone orbital volume restoration control. The feasibility of this technique was checked in 3 patients with major orbito-zygomatic deformities. Preliminary clinical results are presented.

  5. Evolution of Geometric Sensitivity Derivatives from Computer Aided Design Models

    Science.gov (United States)

    Jones, William T.; Lazzara, David; Haimes, Robert

    2010-01-01

    The generation of design parameter sensitivity derivatives is required for gradient-based optimization. Such sensitivity derivatives are elusive at best when working with geometry defined within the solid modeling context of Computer-Aided Design (CAD) systems. Solid modeling CAD systems are often proprietary and always complex, thereby necessitating ad hoc procedures to infer parameter sensitivity. A new perspective is presented that makes direct use of the hierarchical associativity of CAD features to trace their evolution and thereby track design parameter sensitivity. In contrast to ad hoc methods, this method provides a more concise procedure following the model design intent and determining the sensitivity of CAD geometry directly to its respective defining parameters.

  6. Computer-aided modeling framework – a generic modeling template

    DEFF Research Database (Denmark)

    Fedorova, Marina; Sin, Gürkan; Gani, Rafiqul

    This work focuses on the development of a computer-aided modeling framework. The framework is a knowledge-based system that is built on a generic modeling language and structured on workflows for different modeling tasks. The overall objective is to support model developers and users to generate...... and test models systematically, efficiently and reliably. In this way, development of products and processes can be made faster, cheaper and more efficient. In this contribution, as part of the framework, a generic modeling template for the systematic derivation of problem specific models is presented....... The application of the modeling template is highlighted with a case study related to the modeling of a catalytic membrane reactor coupling dehydrogenation of ethylbenzene with hydrogenation of nitrobenzene...

  7. Computer-aided assessment in statistics: the CAMPUS project

    Directory of Open Access Journals (Sweden)

    Neville Hunt

    1998-12-01

    Full Text Available The relentless drive for 'efficiency' in higher education, and the consequent increase in workloads, has given university teachers a compelling incentive to investigate alternative forms of assessment. Some forms of assessment with a clear educational value can no longer be entertained because of the burden placed on the teacher. An added concern is plagiarism, which anecdotal evidence would suggest is on the increase yet which is difficult to detect in large modules with more than one assessor. While computer-aided assessment (CAA has an enthusiastic following, it is not clear to many teachers that it either reduces workloads or reduces the risk of cheating. In an ideal world, most teachers would prefer to give individual attention and personal feedback to each student when marking their work. In this sense CAA must be seen as second best and will therefore be used only if it is seen to offer significant benefits in terms of reduced workloads or increased validity.

  8. Computer Aided Safety Assessment(CASA) Tool for ISS Payloads

    Science.gov (United States)

    Hochstein, Jason; Festa, Fabrizio

    2010-09-01

    In an effort to streamline the processes established by the partners of the International Space Station(ISS) to certify the safety of hardware and experiments destined for the Station, the European Space Agency’s(ESA) ISS System Safety Team is developing the Computer Aided Safety Assessment(CASA) tool suite. These software tools guide payload developers through the creation process of two types of standard payload hazard reports via a series of questions following a predetermined logic. The responses provided by the user are used by the CASA system to complete the majority of each hazard report requisite for payload flight safety reviews, employing consistent, approved descriptions of most hazards, hazard causes, controls and verification methods. Though some manual inputs will still be required to complete these reports, working with CASA will considerably reduce the amount of time necessary to review the documentation by agency safety authorities.

  9. Systematic Methods and Tools for Computer Aided Modelling

    DEFF Research Database (Denmark)

    Fedorova, Marina

    -friendly system, which will make the model development process easier and faster and provide the way for unified and consistent model documentation. The modeller can use the template for their specific problem or to extend and/or adopt a model. This is based on the idea of model reuse, which emphasizes the use...... and processes can be faster, cheaper and very efficient. The developed modelling framework involves five main elements: 1) a modelling tool, that includes algorithms for model generation; 2) a template library, which provides building blocks for the templates (generic models previously developed); 3) computer...... aided methods and tools, that include procedures to perform model translation, model analysis, model verification/validation, model solution and model documentation; 4) model transfer – export/import to/from other application for further extension and application – several types of formats, such as XML...

  10. Computer-Aided Modeling of Lipid Processing Technology

    DEFF Research Database (Denmark)

    Diaz Tovar, Carlos Axel

    2011-01-01

    the analysis, in terms of their design variables and their impact in the process behavior, of three lipid-related processes has been performed: the solvent recovery section of the extraction of crude soybean oil, the deodorization of palm oil, and the deacidification of soybean oil.......Vegetable oils and fats have an important role in human nutrition and in the chemical industry since they are a source of energy, fat-soluble vitamins, and now also in the production of renewable sources of energy. Nowadays as the consumer preferences for natural products and healthier foods...... increase along with growing interest in biofuels, the oleochemical industry faces in the upcoming years major challenges in terms of design and development of better products and more sustainable processes to make them. Computer-aided methods and tools for process synthesis, modeling and simulation...

  11. Peer Feedback in Computer Aided College English Writing Instruction

    Directory of Open Access Journals (Sweden)

    Ma Zhuo

    2016-01-01

    Full Text Available This study is to examine the acceptability of peer feedback in computer aided college English writing instruction. For the whole writing procedure, subjects in language labs were to take preparation, writing and evaluation stages, undergoing three editions suggested by peer feedbacks. For the first time reading, peers would comment on such general scale as subject and content of drafts, and the second focuses on specific items, for example the morphological, lexical and syntactical aspects, etc. To compare students’ attitudes towards the trial, before and after the experiment, Pre-Questionnaire and Post-Questionnaire were adopted to analyze differences. From the frequency of students’ views on ten statements, it is drawn that majority of subjects accept and enjoy the innovative writing process, since peer feedback is an essential and encouraging part for writing.

  12. Computer Vision Aided Measurement of Morphological Features in Medical Optics

    Directory of Open Access Journals (Sweden)

    Bogdana Bologa

    2010-09-01

    Full Text Available This paper presents a computer vision aided method for non invasive interupupillary (IPD distance measurement. IPD is a morphological feature requirement in any oftalmological frame prescription. A good frame prescription is highly dependent nowadays on accurate IPD estimation in order for the lenses to be eye strain free. The idea is to replace the ruler or the pupilometer with a more accurate method while keeping the patient eye free from any moving or gaze restrictions. The method proposed in this paper uses a video camera and a punctual light source in order to determine the IPD with under millimeter error. The results are compared against standard eye and object detection routines from literature.

  13. Automatic computer-aided system of simulating solder joint formation

    Science.gov (United States)

    Zhao, Xiujuan; Wang, Chunqing; Zheng, Guanqun; Wang, Gouzhong; Yang, Shiqin

    1999-08-01

    One critical aspect in electronic packaging is the fatigue/creep-induced failure in solder interconnections, which is found to be highly dependent on the shape of solder joints. Thus predicting and analyzing the solder joint shape is warranted. In this paper, an automatic computer-aided system is developed to simulate the formation of solder joint and analyze the influence of the different process parameters on the solder joint shape. The developed system is capable of visually designing the process parameters and calculating the solder joint shape automatically without any intervention from the user. The automation achieved will enable fast shape estimation with the variation of process parameters without time consuming experiments, and the simulating system provides the design and manufacturing engineers an efficient software tools to design soldering process in design environment. Moreover, a program developed from the system can serve as the preprocessor for subsequent finite element joint analysis program.

  14. Fracture resistance of computer-aided design/computer-aided manufacturing-generated composite resin-based molar crowns.

    Science.gov (United States)

    Harada, Akio; Nakamura, Keisuke; Kanno, Taro; Inagaki, Ryoichi; Örtengren, Ulf; Niwano, Yoshimi; Sasaki, Keiichi; Egusa, Hiroshi

    2015-04-01

    The aim of this study was to investigate whether different fabrication processes, such as the computer-aided design/computer-aided manufacturing (CAD/CAM) system or the manual build-up technique, affect the fracture resistance of composite resin-based crowns. Lava Ultimate (LU), Estenia C&B (EC&B), and lithium disilicate glass-ceramic IPS e.max press (EMP) were used. Four types of molar crowns were fabricated: CAD/CAM-generated composite resin-based crowns (LU crowns); manually built-up monolayer composite resin-based crowns (EC&B-monolayer crowns); manually built-up layered composite resin-based crowns (EC&B-layered crowns); and EMP crowns. Each type of crown was cemented to dies and the fracture resistance was tested. EC&B-layered crowns showed significantly lower fracture resistance compared with LU and EMP crowns, although there was no significant difference in flexural strength or fracture toughness between LU and EC&B materials. Micro-computed tomography and fractographic analysis showed that decreased strength probably resulted from internal voids in the EC&B-layered crowns introduced by the layering process. There was no significant difference in fracture resistance among LU, EC&B-monolayer, and EMP crowns. Both types of composite resin-based crowns showed fracture loads of >2000 N, which is higher than the molar bite force. Therefore, CAD/CAM-generated crowns, without internal defects, may be applied to molar regions with sufficient fracture resistance. © 2015 Eur J Oral Sci.

  15. Micrometric precision of prosthetic dental crowns obtained by optical scanning and computer-aided designing/computer-aided manufacturing system

    Science.gov (United States)

    das Neves, Flávio Domingues; de Almeida Prado Naves Carneiro, Thiago; do Prado, Célio Jesus; Prudente, Marcel Santana; Zancopé, Karla; Davi, Letícia Resende; Mendonça, Gustavo; Soares, Carlos José

    2014-08-01

    The current study evaluated prosthetic dental crowns obtained by optical scanning and a computer-aided designing/computer-aided manufacturing system using micro-computed tomography to compare the marginal fit. The virtual models were obtained with four different scanning surfaces: typodont (T), regular impressions (RI), master casts (MC), and powdered master casts (PMC). Five virtual models were obtained for each group. For each model, a crown was designed on the software and milled from feldspathic ceramic blocks. Micro-CT images were obtained for marginal gap measurements and the data were statistically analyzed by one-way analysis of variance followed by Tukey's test. The mean vertical misfit was T=62.6±65.2 μm; MC=60.4±38.4 μm; PMC=58.1±38.0 μm, and RI=89.8±62.8 μm. Considering a percentage of vertical marginal gap of up to 75 μm, the results were T=71.5%, RI=49.2%, MC=69.6%, and PMC=71.2%. The percentages of horizontal overextension were T=8.5%, RI=0%, MC=0.8%, and PMC=3.8%. Based on the results, virtual model acquisition by scanning the typodont (simulated mouth) or MC, with or without powder, showed acceptable values for the marginal gap. The higher result of marginal gap of the RI group suggests that it is preferable to scan this directly from the mouth or from MC.

  16. Computer aided diagnosis for breast masses detection on a telemammography system.

    Science.gov (United States)

    Méndez, Arturo J; Souto, Miguel; Tahoces, Pablo G; Vidal, Juan J

    2003-01-01

    A Computer-Aided Diagnosis (CAD) scheme for breast masses detection has been developed and integrated as a part of a telemammography system. This work derives from the close cooperation between the Laboratory for Radiologic Image Research of the University of Santiago de Compostela (Spain) and the company Intelsis Sistemas Inteligentes (Santiago de Compostela, Spain). This cooperation has been supported by funds from different projects, mainly from the European Union, the Spanish Health Administration, and the Galician Public Health's Service. As a result, a first prototype is ready to begin a demonstration project.

  17. Role of computer-aided drug design in modern drug discovery.

    Science.gov (United States)

    Macalino, Stephani Joy Y; Gosu, Vijayakumar; Hong, Sunhye; Choi, Sun

    2015-09-01

    Drug discovery utilizes chemical biology and computational drug design approaches for the efficient identification and optimization of lead compounds. Chemical biology is mostly involved in the elucidation of the biological function of a target and the mechanism of action of a chemical modulator. On the other hand, computer-aided drug design makes use of the structural knowledge of either the target (structure-based) or known ligands with bioactivity (ligand-based) to facilitate the determination of promising candidate drugs. Various virtual screening techniques are now being used by both pharmaceutical companies and academic research groups to reduce the cost and time required for the discovery of a potent drug. Despite the rapid advances in these methods, continuous improvements are critical for future drug discovery tools. Advantages presented by structure-based and ligand-based drug design suggest that their complementary use, as well as their integration with experimental routines, has a powerful impact on rational drug design. In this article, we give an overview of the current computational drug design and their application in integrated rational drug development to aid in the progress of drug discovery research.

  18. Software Infrastructure for Computer-aided Drug Discovery and Development, a Practical Example with Guidelines.

    Science.gov (United States)

    Moretti, Loris; Sartori, Luca

    2016-09-01

    In the field of Computer-Aided Drug Discovery and Development (CADDD) the proper software infrastructure is essential for everyday investigations. The creation of such an environment should be carefully planned and implemented with certain features in order to be productive and efficient. Here we describe a solution to integrate standard computational services into a functional unit that empowers modelling applications for drug discovery. This system allows users with various level of expertise to run in silico experiments automatically and without the burden of file formatting for different software, managing the actual computation, keeping track of the activities and graphical rendering of the structural outcomes. To showcase the potential of this approach, performances of five different docking programs on an Hiv-1 protease test set are presented.

  19. The application of computer-aided technologies in automotive styling design

    Science.gov (United States)

    Zheng, Ze-feng; Zhang, Ji; Zheng, Ying

    2012-04-01

    In automotive industry, outline design is its life and creative design is its soul indeed. Computer-aided technology has been widely used in the automotive industry and more and more attention has been paid. This paper chiefly introduce the application of computer-aided technologies including CAD, CAM and CAE, analyses the process of automotive structural design and describe the development tendency of computer-aided design.

  20. Converting Between PLY and Ballistic Research Laboratory-Computer-Aided Design (BRL-CAD) File Formats

    Science.gov (United States)

    2015-02-01

    Converting Between PLY and Ballistic Research Laboratory–Computer-Aided Design (BRL- CAD ) File Formats by Rishub Jain ARL-CR-0760...0760 February 2015 Converting Between PLY and Ballistic Research Laboratory–Computer-Aided Design (BRL- CAD ) File Formats Rishub Jain US...and Ballistic Research Laboratory–Computer-Aided Design (BRL- CAD ) File Formats 5a. CONTRACT NUMBER W911NF-10-2-0076 5b. GRANT NUMBER 5c. PROGRAM

  1. Target Impact Detection Algorithm Using Computer-aided Design (CAD) Model Geometry

    Science.gov (United States)

    2014-09-01

    UNCLASSIFIED AD-E403 558 Technical Report ARMET-TR-13024 TARGET IMPACT DETECTION ALGORITHM USING COMPUTER-AIDED DESIGN ( CAD ...DETECTION ALGORITHM USING COMPUTER-AIDED DESIGN ( CAD ) MODEL GEOMETRY 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...This report documents a method and algorithm to export geometry from a three-dimensional, computer-aided design ( CAD ) model in a format that can be

  2. Computer-based clinical decision aids. A review of methods and assessment of systems.

    Science.gov (United States)

    Reisman, Y

    1996-01-01

    During the last three decades a great deal of research has been devoted to the development of integrated clinical decision support systems. This report aims to give a basic understanding of what is required for such a system. By means of a large literature study a survey is given of the major components of computer-based clinical aid systems. The main approaches and several aspects of evaluation of such programs are described. The computer has several inherent capabilities which are suitable for medical problem solving and can help in the formalization of medical knowledge. The components of such systems include the computer database, the reasoning engine and the user interface. The different approaches on which the reasoning engine is built are based on manipulation of information and advocate the use of knowledge to construct a solution to a problem. The information in the mode vary from data-intensive to knowledge-intensive. Assessment of decision support systems is a very important phase in the development of such systems. Evaluation should be made on the accuracy of the program, the nature of the system, the use of the data and the acceptance by the target users. Whatever the model is, its effectiveness will depend on the data with which the program has to work. Acceptance by physicians depends among other things on ease of use of the user interface. Profound changes in the delivery of health care will be induced through the rapid growth of on-line computer communication together with the development of integrated clinical decision support systems and electronic medical records. Notwithstanding the rapid growth of computer technology, computer-aided decision making is in its infancy and real support in daily practice is not yet achieved.

  3. Approximation method to compute domain related integrals in structural studies

    Science.gov (United States)

    Oanta, E.; Panait, C.; Raicu, A.; Barhalescu, M.; Axinte, T.

    2015-11-01

    Various engineering calculi use integral calculus in theoretical models, i.e. analytical and numerical models. For usual problems, integrals have mathematical exact solutions. If the domain of integration is complicated, there may be used several methods to calculate the integral. The first idea is to divide the domain in smaller sub-domains for which there are direct calculus relations, i.e. in strength of materials the bending moment may be computed in some discrete points using the graphical integration of the shear force diagram, which usually has a simple shape. Another example is in mathematics, where the surface of a subgraph may be approximated by a set of rectangles or trapezoids used to calculate the definite integral. The goal of the work is to introduce our studies about the calculus of the integrals in the transverse section domains, computer aided solutions and a generalizing method. The aim of our research is to create general computer based methods to execute the calculi in structural studies. Thus, we define a Boolean algebra which operates with ‘simple’ shape domains. This algebraic standpoint uses addition and subtraction, conditioned by the sign of every ‘simple’ shape (-1 for the shapes to be subtracted). By ‘simple’ shape or ‘basic’ shape we define either shapes for which there are direct calculus relations, or domains for which their frontiers are approximated by known functions and the according calculus is carried out using an algorithm. The ‘basic’ shapes are linked to the calculus of the most significant stresses in the section, refined aspect which needs special attention. Starting from this idea, in the libraries of ‘basic’ shapes, there were included rectangles, ellipses and domains whose frontiers are approximated by spline functions. The domain triangularization methods suggested that another ‘basic’ shape to be considered is the triangle. The subsequent phase was to deduce the exact relations for the

  4. Call Centre- Computer Telephone Integration

    Directory of Open Access Journals (Sweden)

    Dražen Kovačević

    2012-10-01

    Full Text Available Call centre largely came into being as a result of consumerneeds converging with enabling technology- and by the companiesrecognising the revenue opportunities generated by meetingthose needs thereby increasing customer satisfaction. Regardlessof the specific application or activity of a Call centre, customersatisfaction with the interaction is critical to the revenuegenerated or protected by the Call centre. Physical(v, Call centreset up is a place that includes computer, telephone and supervisorstation. Call centre can be available 24 hours a day - whenthe customer wants to make a purchase, needs information, orsimply wishes to register a complaint.

  5. Computer-aided Teaching of Math in Electromechanics Vocational Course

    Directory of Open Access Journals (Sweden)

    Eduardo Shigueo Hoji

    2013-03-01

    Full Text Available This paper describes the experience of teaching mathematics in the electromechanics vocational course with aid of the computer. Instead of giving a bunch of equations and a calculator to the students, as it is usual in vocational courses, we offer them Octave, which is a numerical computational tool. Furthermore, the mathematical concepts involved in the solution of applied problems are provided within a multidisciplinary framework. The proposed approach helped to reduce the abstraction of mathematics for the students. Despite the deficiencies the students in vocational courses have in their formation, we could notice that their perception regarding mathematics has changed after figuring out that “a bunch of numbers” can be useful in the solution of problems they shall face in their professional life. The approach was applied to three groups already. All of them are composed of mature students, who passed by a flawed basic educational system and stayed away from school for a long time.

  6. A digital patient for computer-aided prosthesis design.

    Science.gov (United States)

    Colombo, Giorgio; Facoetti, Giancarlo; Rizzi, Caterina

    2013-04-06

    This article concerns the design of lower limb prosthesis, both below and above knee. It describes a new computer-based design framework and a digital model of the patient around which the prosthesis is designed and tested in a completely virtual environment. The virtual model of the patient is the backbone of the whole system, and it is based on a biomechanical general-purpose model customized with the patient's characteristics (e.g. anthropometric measures). The software platform adopts computer-aided and knowledge-guided approaches with the goal of replacing the current development process, mainly hand made, with a virtual one. It provides the prosthetics with a set of tools to design, configure and test the prosthesis and comprehends two main environments: the prosthesis modelling laboratory and the virtual testing laboratory. The first permits the three-dimensional model of the prosthesis to be configured and generated, while the second allows the prosthetics to virtually set up the artificial leg and simulate the patient's postures and movements, validating its functionality and configuration. General architecture and modelling/simulation tools for the platform are described as well as main aspects and results of the experimentation.

  7. 3D Computer aided treatment planning in endodontics.

    Science.gov (United States)

    van der Meer, Wicher J; Vissink, Arjan; Ng, Yuan Ling; Gulabivala, Kishor

    2016-02-01

    Obliteration of the root canal system due to accelerated dentinogenesis and dystrophic calcification can challenge the achievement of root canal treatment goals. This paper describes the application of 3D digital mapping technology for predictable navigation of obliterated canal systems during root canal treatment to avoid iatrogenic damage of the root. Digital endodontic treatment planning for anterior teeth with severely obliterated root canal systems was accomplished with the aid of computer software, based on cone beam computer tomography (CBCT) scans and intra-oral scans of the dentition. On the basis of these scans, endodontic guides were created for the planned treatment through digital designing and rapid prototyping fabrication. The custom-made guides allowed for an uncomplicated and predictable canal location and management. The method of digital designing and rapid prototyping of endodontic guides allows for reliable and predictable location of root canals of teeth with calcifically metamorphosed root canal systems. The endodontic directional guide facilitates difficult endodontic treatments at little additional cost. Copyright © 2016. Published by Elsevier Ltd.

  8. Computer-Aided Sensor Development Focused on Security Issues

    Directory of Open Access Journals (Sweden)

    Andrzej Bialas

    2016-05-01

    Full Text Available The paper examines intelligent sensor and sensor system development according to the Common Criteria methodology, which is the basic security assurance methodology for IT products and systems. The paper presents how the development process can be supported by software tools, design patterns and knowledge engineering. The automation of this process brings cost-, quality-, and time-related advantages, because the most difficult and most laborious activities are software-supported and the design reusability is growing. The paper includes a short introduction to the Common Criteria methodology and its sensor-related applications. In the experimental section the computer-supported and patterns-based IT security development process is presented using the example of an intelligent methane detection sensor. This process is supported by an ontology-based tool for security modeling and analyses. The verified and justified models are transferred straight to the security target specification representing security requirements for the IT product. The novelty of the paper is to provide a patterns-based and computer-aided methodology for the sensors development with a view to achieving their IT security assurance. The paper summarizes the validation experiment focused on this methodology adapted for the sensors system development, and presents directions of future research.

  9. Computer aided lung cancer diagnosis with deep learning algorithms

    Science.gov (United States)

    Sun, Wenqing; Zheng, Bin; Qian, Wei

    2016-03-01

    Deep learning is considered as a popular and powerful method in pattern recognition and classification. However, there are not many deep structured applications used in medical imaging diagnosis area, because large dataset is not always available for medical images. In this study we tested the feasibility of using deep learning algorithms for lung cancer diagnosis with the cases from Lung Image Database Consortium (LIDC) database. The nodules on each computed tomography (CT) slice were segmented according to marks provided by the radiologists. After down sampling and rotating we acquired 174412 samples with 52 by 52 pixel each and the corresponding truth files. Three deep learning algorithms were designed and implemented, including Convolutional Neural Network (CNN), Deep Belief Networks (DBNs), Stacked Denoising Autoencoder (SDAE). To compare the performance of deep learning algorithms with traditional computer aided diagnosis (CADx) system, we designed a scheme with 28 image features and support vector machine. The accuracies of CNN, DBNs, and SDAE are 0.7976, 0.8119, and 0.7929, respectively; the accuracy of our designed traditional CADx is 0.7940, which is slightly lower than CNN and DBNs. We also noticed that the mislabeled nodules using DBNs are 4% larger than using traditional CADx, this might be resulting from down sampling process lost some size information of the nodules.

  10. Computer-Aided Sensor Development Focused on Security Issues.

    Science.gov (United States)

    Bialas, Andrzej

    2016-05-26

    The paper examines intelligent sensor and sensor system development according to the Common Criteria methodology, which is the basic security assurance methodology for IT products and systems. The paper presents how the development process can be supported by software tools, design patterns and knowledge engineering. The automation of this process brings cost-, quality-, and time-related advantages, because the most difficult and most laborious activities are software-supported and the design reusability is growing. The paper includes a short introduction to the Common Criteria methodology and its sensor-related applications. In the experimental section the computer-supported and patterns-based IT security development process is presented using the example of an intelligent methane detection sensor. This process is supported by an ontology-based tool for security modeling and analyses. The verified and justified models are transferred straight to the security target specification representing security requirements for the IT product. The novelty of the paper is to provide a patterns-based and computer-aided methodology for the sensors development with a view to achieving their IT security assurance. The paper summarizes the validation experiment focused on this methodology adapted for the sensors system development, and presents directions of future research.

  11. Computer-Aided Design of Nanocapsules for Therapeutic Delivery

    Directory of Open Access Journals (Sweden)

    Zeina Shreif

    2009-01-01

    Full Text Available The design of nanocapsules for targeted delivery of therapeutics presents many, often seemingly self-contradictory, constraints. An algorithm for predicting the physico-chemical characteristics of nanocapsule delivery and payload release using a novel all-atom, multiscale technique is presented. This computational method preserves key atomic-scale behaviours needed to make predictions of interactions of functionalized nanocapsules with the cell surface receptors, drug, siRNA, gene or other payload. We show how to introduce a variety of order parameters with distinct character to enable a multiscale analysis of a complex system. The all-atom formulation allows for the use of an interatomic force field, making the approach universal and avoiding recalibration with each new application. Alternatively, key parameters, which minimize the need for calibration, are also identified. Simultaneously, the methodology enables predictions of the supra-nanometer-scale behaviour, such as structural transitions and disassembly of the nanocapsule accompanying timed payload release or due to premature degradation. The final result is a Fokker–Planck equation governing the rate of stochastic payload release and structural changes and migration accompanying it. A novel “salt shaker” effect that underlies fluctuation-enhancement of payload delivery is presented. Prospects for computer-aided design of nanocapsule delivery system are discussed.

  12. The promise of computer aided detection in digital mammography

    Energy Technology Data Exchange (ETDEWEB)

    Roehrig, Jimmy E-mail: jimmy@enrico.r2tech.com; Castellino, Ronald A. E-mail: castellr@mskcc.org

    1999-07-01

    Computer-aided detection (CAD) is a new technology now being implemented in many clinics to reduce the false negative rate in mammography screening. A large clinical study has been completed which shows that a substantial false negative (miss) rate exists in screening mammography, a significant fraction of the missed cancers are not subtle, and CAD has high sensitivity to these missed cancers. Full field digital mammography is now coming on the scene, but has not yet been proven in clinical practice. The authors believe that full acceptance of the new digital technology depends not merely on demonstrations of 'substantial equivalence' to film-screen technology, but rather on more complete exploitation of the unique advantages of digital technology, and that CAD can play a key role. These advantages derive from CAD's ability to quickly (in near real-time) perform analytical computations on digital information that is not readily available to the radiologist until after the cost of film-processing has occurred.

  13. A handheld computer-aided diagnosis system and simulated analysis

    Science.gov (United States)

    Su, Mingjian; Zhang, Xuejun; Liu, Brent; Su, Kening; Louie, Ryan

    2016-03-01

    This paper describes a Computer Aided Diagnosis (CAD) system based on cellphone and distributed cluster. One of the bottlenecks in building a CAD system for clinical practice is the storage and process of mass pathology samples freely among different devices, and normal pattern matching algorithm on large scale image set is very time consuming. Distributed computation on cluster has demonstrated the ability to relieve this bottleneck. We develop a system enabling the user to compare the mass image to a dataset with feature table by sending datasets to Generic Data Handler Module in Hadoop, where the pattern recognition is undertaken for the detection of skin diseases. A single and combination retrieval algorithm to data pipeline base on Map Reduce framework is used in our system in order to make optimal choice between recognition accuracy and system cost. The profile of lesion area is drawn by doctors manually on the screen, and then uploads this pattern to the server. In our evaluation experiment, an accuracy of 75% diagnosis hit rate is obtained by testing 100 patients with skin illness. Our system has the potential help in building a novel medical image dataset by collecting large amounts of gold standard during medical diagnosis. Once the project is online, the participants are free to join and eventually an abundant sample dataset will soon be gathered enough for learning. These results demonstrate our technology is very promising and expected to be used in clinical practice.

  14. Collaborative and distributed computing applied to biomedicine with the FightAIDS@Home

    Directory of Open Access Journals (Sweden)

    BARBOSA, G. C.

    2011-12-01

    Full Text Available Distributed computing systems are used for high performance computing tasks, taking advantage of join processing power of multiple independent computers, but they are interconnected by network. These high performance systems can be divided into two classes of distributed computing systems: computer cluster and grid computing. The FightAIDS@Home is a distributed system toward the search for solutions for the AIDS treatment, and this project is led by the Olson Laboratory, California. Nowadays, this project use computing resources of the Grid World Community Grid, which consist mostly of computers of ordinary users, using open and non-specific standard protocols and interfaces to ensure interoperability between different systems. These paper presents informations from a case study about FightAIDS@Home and its implementation, using aspects of distributed systems such as grid computer and cloud computing to support implementation of collaborative computing.

  15. [PIV: a computer-aided portal image verification system].

    Science.gov (United States)

    Fu, Weihua; Zhang, Hongzhi; Wu, Jing

    2002-12-01

    Portal image verification (PIV) is one of the key actions in QA procedure for sophisticated accurate radiotherapy. The purpose of this study was to develop a PIV software as a tool for improving the accuracy and visualization of portal field verification and computing field placement errors. PIV was developed in the visual C++ integrated environment under Windows 95 operating system. It can improve visualization by providing tools for image processing and multimode images display. Semi-automatic register methods make verification more accurate than view-box method. It can provide useful quantitative errors for regular fields. PIV is flexible and accurate. It is an effective tool for portal field verification.

  16. Computer-Presented Organizational/Memory Aids as Instruction for Solving Pico-Fomi Problems.

    Science.gov (United States)

    Steinberg, Esther R.; And Others

    1985-01-01

    Describes investigation of effectiveness of computer-presented organizational/memory aids (matrix and verbal charts controlled by computer or learner) as instructional technique for solving Pico-Fomi problems, and the acquisition of deductive inference rules when such aids are present. Results indicate chart use control should be adapted to…

  17. Teaching Computer-Aided Design of Fluid Flow and Heat Transfer Engineering Equipment.

    Science.gov (United States)

    Gosman, A. D.; And Others

    1979-01-01

    Describes a teaching program for fluid mechanics and heat transfer which contains both computer aided learning (CAL) and computer aided design (CAD) components and argues that the understanding of the physical and numerical modeling taught in the CAL course is essential to the proper implementation of CAD. (Author/CMV)

  18. [The automatic iris map overlap technology in computer-aided iridiagnosis].

    Science.gov (United States)

    He, Jia-feng; Ye, Hu-nian; Ye, Miao-yuan

    2002-11-01

    In the paper, iridology and computer-aided iridiagnosis technologies are briefly introduced and the extraction method of the collarette contour is then investigated. The iris map can be overlapped on the original iris image based on collarette contour extraction. The research on collarette contour extraction and iris map overlap is of great importance to computer-aided iridiagnosis technologies.

  19. Computer-aided Diagnosis: How to Move from the Laboratory to the Clinic.

    NARCIS (Netherlands)

    Ginneken, B. van; Schaefer-Prokop, C.M.; Prokop, M.

    2011-01-01

    Computer-aided diagnosis (CAD), encompassing computer-aided detection and quantification, is an established and rapidly growing field of research. In daily practice, however, most radiologists do not yet use CAD routinely. This article discusses how to move CAD from the laboratory to the clinic. The

  20. Enabling Lean Design Through Computer Aided Synthesis: The Injection Moulding Cooling Case

    NARCIS (Netherlands)

    Jauregui Becker, Juan M.; Wits, Wessel W.

    2015-01-01

    This paper explores the application of Computer Aided Synthesis (CAS) to support the implementation of Set-Based Concurrent Engineering (SBCE) and Just In Time Decision Making (JIT-DM), which are considered as two of the cornerstones of the Lean Design method. Computer Aided Synthesis refers to a ne

  1. A Paper Presentation on Software Development Automation by Computer Aided Software Engineering (CASE

    Directory of Open Access Journals (Sweden)

    Nishant Dubey

    2011-01-01

    Full Text Available Nowadays, system developers are faced to produce complex, high quality software to support the demand for new and revised computer applications. This challenge is complicated by strict resource constraints, forcing management to deploy new technologies, methods and procedures to manage this increasingly complex environment. Often the methods, procedures and technologies are not integrated. Therefore, they achieve less than desired improvements in productivity, or force management to make tradeoff decisions between software quality and developer efficiency. Thus the production lines have to be developed faster, too. A very important role in this development is Software Engineering because many production processes are 'computer aided', so software has to be designed for this production system. It seems very important to do the software engineering right and fast.

  2. Computer aided process planning and die design in simulation environment in sheet metal forming

    Science.gov (United States)

    Tisza, Miklós; Lukács, Zsolt

    2013-12-01

    During the recent 10-15 years, Computer Aided Process Planning and Die Design evolved as one of the most important engineering tools in sheet metal forming, particularly in the automotive industry. This emerging role is strongly emphasized by the rapid development of Finite Element Modeling, as well. The purpose of this paper is to give a general overview about the recent achievements in this very important field of sheet metal forming and to introduce some special results in this development activity. Therefore, in this paper, an integrated process simulation and die design system developed at the University of Miskolc, Department of Mechanical Engineering will be analyzed. The proposed integrated solutions have great practical importance to improve the global competitiveness of sheet metal forming in the very important segment of industry. The concept described in this paper may have specific value both for process planning and die design engineers.

  3. Entropy computing via integration over fractal measures.

    Science.gov (United States)

    Słomczynski, Wojciech; Kwapien, Jarosław; Zyczkowski, Karol

    2000-03-01

    We discuss the properties of invariant measures corresponding to iterated function systems (IFSs) with place-dependent probabilities and compute their Renyi entropies, generalized dimensions, and multifractal spectra. It is shown that with certain dynamical systems, one can associate the corresponding IFSs in such a way that their generalized entropies are equal. This provides a new method of computing entropy for some classical and quantum dynamical systems. Numerical techniques are based on integration over the fractal measures. (c) 2000 American Institute of Physics.

  4. Computer-Aided Construction of Chemical Kinetic Models

    Energy Technology Data Exchange (ETDEWEB)

    Green, William H. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

    2014-12-31

    The combustion chemistry of even simple fuels can be extremely complex, involving hundreds or thousands of kinetically significant species. The most reasonable way to deal with this complexity is to use a computer not only to numerically solve the kinetic model, but also to construct the kinetic model in the first place. Because these large models contain so many numerical parameters (e.g. rate coefficients, thermochemistry) one never has sufficient data to uniquely determine them all experimentally. Instead one must work in “predictive” mode, using theoretical rather than experimental values for many of the numbers in the model, and as appropriate refining the most sensitive numbers through experiments. Predictive chemical kinetics is exactly what is needed for computer-aided design of combustion systems based on proposed alternative fuels, particularly for early assessment of the value and viability of proposed new fuels before those fuels are commercially available. This project was aimed at making accurate predictive chemical kinetics practical; this is a challenging goal which requires a range of science advances. The project spanned a wide range from quantum chemical calculations on individual molecules and elementary-step reactions, through the development of improved rate/thermo calculation procedures, the creation of algorithms and software for constructing and solving kinetic simulations, the invention of methods for model-reduction while maintaining error control, and finally comparisons with experiment. Many of the parameters in the models were derived from quantum chemistry calculations, and the models were compared with experimental data measured in our lab or in collaboration with others.

  5. Hybrid Parallel Computation of Integration in GRACE

    CERN Document Server

    Yuasa, F; Kawabata, S; Perret-Gallix, D; Itakura, K; Hotta, Y; Okuda, M; Yuasa, Fukuko; Ishikawa, Tadashi; Kawabata, Setsuya; Perret-Gallix, Denis; Itakura, Kazuhiro; Hotta, Yukihiko; Okuda, Motoi

    2000-01-01

    With an integrated software package {\\tt GRACE}, it is possible to generate Feynman diagrams, calculate the total cross section and generate physics events automatically. We outline the hybrid method of parallel computation of the multi-dimensional integration of {\\tt GRACE}. We used {\\tt MPI} (Message Passing Interface) as the parallel library and, to improve the performance we embedded the mechanism of the dynamic load balancing. The reduction rate of the practical execution time was studied.

  6. CART V: recent advancements in computer-aided camouflage assessment

    Science.gov (United States)

    Müller, Thomas; Müller, Markus

    2011-05-01

    In order to facilitate systematic, computer aided improvements of camouflage and concealment assessment methods, the software system CART (Camouflage Assessment in Real-Time) was built up for the camouflage assessment of objects in multispectral image sequences (see contributions to SPIE 2007-2010 [1], [2], [3], [4]). It comprises a semi-automatic marking of target objects (ground truth generation) including their propagation over the image sequence and the evaluation via user-defined feature extractors as well as methods to assess the object's movement conspicuity. In this fifth part in an annual series at the SPIE conference in Orlando, this paper presents the enhancements over the recent year and addresses the camouflage assessment of static and moving objects in multispectral image data that can show noise or image artefacts. The presented methods fathom the correlations between image processing and camouflage assessment. A novel algorithm is presented based on template matching to assess the structural inconspicuity of an object objectively and quantitatively. The results can easily be combined with an MTI (moving target indication) based movement conspicuity assessment function in order to explore the influence of object movement to a camouflage effect in different environments. As the results show, the presented methods contribute to a significant benefit in the field of camouflage assessment.

  7. ARCHITECTURE OF WEB BASED COMPUTER-AIDED MANUFACTURING SYSTEM

    Directory of Open Access Journals (Sweden)

    N. E. Filyukov

    2014-09-01

    Full Text Available The paper deals with design of a web-based system for Computer-Aided Manufacturing (CAM. Remote applications and databases located in the "private cloud" are proposed to be the basis of such system. The suggested approach contains: service - oriented architecture, using web applications and web services as modules, multi-agent technologies for implementation of information exchange functions between the components of the system and the usage of PDM - system for managing technology projects within the CAM. The proposed architecture involves CAM conversion into the corporate information system that will provide coordinated functioning of subsystems based on a common information space, as well as parallelize collective work on technology projects and be able to provide effective control of production planning. A system has been developed within this architecture which gives the possibility for a rather simple technological subsystems connect to the system and implementation of their interaction. The system makes it possible to produce CAM configuration for a particular company on the set of developed subsystems and databases specifying appropriate access rights for employees of the company. The proposed approach simplifies maintenance of software and information support for CAM subsystems due to their central location in the data center. The results can be used as a basis for CAM design and testing within the learning process for development and modernization of the system algorithms, and then can be tested in the extended enterprise.

  8. Computer aided polymer design using multi-scale modelling

    Directory of Open Access Journals (Sweden)

    K. C. Satyanarayana

    2010-09-01

    Full Text Available The ability to predict the key physical and chemical properties of polymeric materials from their repeat-unit structure and chain-length architecture prior to synthesis is of great value for the design of polymer-based chemical products, with new functionalities and improved performance. Computer aided molecular design (CAMD methods can expedite the design process by establishing input-output relations between the type and number of functional groups in a polymer repeat unit and the desired macroscopic properties. A multi-scale model-based approach that combines a CAMD technique based on group contribution plus models for predicting polymer repeat unit properties with atomistic simulations for providing first-principles arrangements of the repeat units and for predictions of physical properties of the chosen candidate polymer structures, has been developed and tested for design of polymers with desired properties. A case study is used to highlight the main features of this multi-scale model-based approach for the design of a polymer-based product.

  9. The future of computer-aided sperm analysis

    Directory of Open Access Journals (Sweden)

    Sharon T Mortimer

    2015-01-01

    Full Text Available Computer-aided sperm analysis (CASA technology was developed in the late 1980s for analyzing sperm movement characteristics or kinematics and has been highly successful in enabling this field of research. CASA has also been used with great success for measuring semen characteristics such as sperm concentration and proportions of progressive motility in many animal species, including wide application in domesticated animal production laboratories and reproductive toxicology. However, attempts to use CASA for human clinical semen analysis have largely met with poor success due to the inherent difficulties presented by many human semen samples caused by sperm clumping and heavy background debris that, until now, have precluded accurate digital image analysis. The authors review the improved capabilities of two modern CASA platforms (Hamilton Thorne CASA-II and Microptic SCA6 and consider their current and future applications with particular reference to directing our focus towards using this technology to assess functional rather than simple descriptive characteristics of spermatozoa. Specific requirements for validating CASA technology as a semi-automated system for human semen analysis are also provided, with particular reference to the accuracy and uncertainty of measurement expected of a robust medical laboratory test for implementation in clinical laboratories operating according to modern accreditation standards.

  10. Computer-aided interpretation approach for optical tomographic images

    Science.gov (United States)

    Klose, Christian D.; Klose, Alexander D.; Netz, Uwe J.; Scheel, Alexander K.; Beuthan, Jürgen; Hielscher, Andreas H.

    2010-11-01

    A computer-aided interpretation approach is proposed to detect rheumatic arthritis (RA) in human finger joints using optical tomographic images. The image interpretation method employs a classification algorithm that makes use of a so-called self-organizing mapping scheme to classify fingers as either affected or unaffected by RA. Unlike in previous studies, this allows for combining multiple image features, such as minimum and maximum values of the absorption coefficient for identifying affected and not affected joints. Classification performances obtained by the proposed method were evaluated in terms of sensitivity, specificity, Youden index, and mutual information. Different methods (i.e., clinical diagnostics, ultrasound imaging, magnet resonance imaging, and inspection of optical tomographic images), were used to produce ground truth benchmarks to determine the performance of image interpretations. Using data from 100 finger joints, findings suggest that some parameter combinations lead to higher sensitivities, while others to higher specificities when compared to single parameter classifications employed in previous studies. Maximum performances are reached when combining the minimum/maximum ratio of the absorption coefficient and image variance. In this case, sensitivities and specificities over 0.9 can be achieved. These values are much higher than values obtained when only single parameter classifications were used, where sensitivities and specificities remained well below 0.8.

  11. Computer-aided simulation of the heat treatment

    Energy Technology Data Exchange (ETDEWEB)

    Arola, R.; Martikainen, H.; Virta, J. [Technical Research Centre of Finland, Espoo (Finland). Metallurgy Lab.

    1993-12-31

    Computer-aided simulation of the heat treatment of components and charges is examined. Existing programs for the simulation of heat treatment are reviewed. Test simulations including calculation of temperature, phase composition and stresses and strains during heating and cooling are performed with selected programs. The results of the simulations are compared with the results of heat treating experiments. Heat transfer during heating-up varies considerably between different treatments, components of the charge and surfaces of the component. Therefore, heat transfer data defined on the basis of the measurements has to be used in exact simulation instead of literature data. According to the simulation results non-uniform temperature distribution, plastic straining and residual stresses after heating can be formed in an AISI 316 bar heated up at the edge of a charge in a pit furnace. Permanent bending of these bars as a result of heating is not observed. In the oil quenching of a 42CrMo4 cylinder, where martensite and bainite are formed in austenite decomposition, the simulation results (especially amounts of phases and residual stresses) are crucially dependent on the TTT-diagram describing the kinetics of the phase transformations. Several TTT-diagrams for the steel grade are found, leading to different simulation results

  12. COMPUTER-AIDED DETECTION OF ACINAR SHADOWS IN CHEST RADIOGRAPHS

    Directory of Open Access Journals (Sweden)

    Tao Xu

    2013-05-01

    Full Text Available Despite the technological advances in medical diagnosis, accurate detection of infectious tuberculosis (TB still poses challenges due to complex image features and thus infectious TB continues to be a public health problem of global proportions. Currently, the detection of TB is mainly conducted visually by radiologists examining chest radiographs (CXRs. To reduce the backlog of CXR examination and provide more precise quantitative assessment, computer-aided detection (CAD systems for potential lung lesions have been increasingly adopted and commercialized for clinical practice. CADs work as supporting tools to alert radiologists on suspected features that could have easily been neglected. In this paper, an effective CAD system aimed for acinar shadow regions detection in CXRs is proposed. This system exploits textural and photometric features analysis techniques which include local binary pattern (LBP, grey level co-occurrence matrix (GLCM and histogram of oriented gradients (HOG to analyze target regions in CXRs. Classification of acinar shadows using Adaboost is then deployed to verify the performance of a combination of these techniques. Comparative study in different image databases shows that the proposed CAD system delivers consistent high accuracy in detecting acinar shadows.

  13. A computer-aided diagnostic system for kidney disease

    Science.gov (United States)

    Jahantigh, Farzad Firouzi; Malmir, Behnam; Avilaq, Behzad Aslani

    2017-01-01

    Background Disease diagnosis is complicated since patients may demonstrate similar symptoms but physician may diagnose different diseases. There are a few number of investigations aimed to create a fuzzy expert system, as a computer aided system for disease diagnosis. Methods In this research, a cross-sectional descriptive study conducted in a kidney clinic in Tehran, Iran in 2012. Medical diagnosis fuzzy rules applied, and a set of symptoms related to the set of considered diseases defined. The input case to be diagnosed defined by assigning a fuzzy value to each symptom and then three physicians asked about each suspected diseases. Then comments of those three physicians summarized for each disease. The fuzzy inference applied to obtain a decision fuzzy set for each disease, and crisp decision values attained to determine the certainty of existence for each disease. Results Results indicated that, in the diagnosis of seven cases of kidney disease by examining 21 indicators using fuzzy expert system, kidney stone disease with 63% certainty was the most probable, renal tubular was at the lowest level with 15%, and other kidney diseases were at the other levels. The most remarkable finding of this study was that results of kidney disease diagnosis (e.g., kidney stone) via fuzzy expert system were fully compatible with those of kidney physicians. Conclusion The proposed fuzzy expert system is a valid, reliable, and flexible instrument to diagnose several typical input cases. The developed system decreases the effort of initial physical checking and manual feeding of input symptoms.

  14. Computer Aided Detection of SARS Based on Radiographs Data Mining.

    Science.gov (United States)

    Xuanyang, Xie; Yuchang, Gong; Shouhong, Wan; Xi, Li

    2005-01-01

    This paper introduces our work on how to use image mining techniques to detect SARS, the severe acute respiratory syndrome, automatically as the prototype of computer aided detection/diagnosis (CAD) system. Data used in this paper are digitalized PA(posterior anterior) X-ray images stored in the real-life picture archiving and communication system (PACS) of the 2nd Affiliation Hospital of Guangzhou Medical College. Association rule mining was applied first but results showed there was no significant difference between the locations of the lesions or infiltrate. Classification based on image textures was performed. A sample set contains both the pneumonia and SARS X-ray images was built in the first place. After modeling each sample by a feature vector, the sample set was partitioned to match the detection purpose: classification. Three methods were used: C4.5, neural network (NN) and CART. Final result shows that 70.94% SARS cases can be detected by CART. Data preparation, segmentation, feature extraction and data mining steps, with corresponding techniques are included in this paper. ROC charts and confusion matrix by all three methods are given and analyzed.

  15. Computer-aided pattern classification system for dermoscopy images.

    Science.gov (United States)

    Abbas, Qaisar; Celebi, M Emre; Fondón, Irene

    2012-08-01

    Computer-aided pattern classification of melanoma and other pigmented skin lesions is one of the most important tasks for clinical diagnosis. To differentiate between benign and malignant lesions, the extraction of color, architectural order, symmetry of pattern and homogeneity (CASH) is a challenging task. In this article, a novel pattern classification system (PCS) based on the clinical CASH rule is presented to classify among six classes of patterns. The PCS system consists of the following five steps: transformation to the CIE L*a*b* color space, pre-processing to enhance the tumor region and removal of hairs, tumor-area segmentation, color and texture feature extraction, and finally, classification based on a multiclass support vector machine. The PCS system is tested on a total of 180 dermoscopic images. To test the performance of the PCS diagnostic classifier, the area under the receiver operating characteristics curve (AUC) is utilized. The proposed classifier achieved a sensitivity of 91.64%, specificity of 94.14%, and AUC of 0.948. The experimental results demonstrate that the proposed pattern classifier is highly accurate and classify between benign and malignant lesions into some extend. The PCS method is fully automatic and can accurately detect different patterns from dermoscopy images using color and texture properties. Additional pattern features can be included to investigate the impact of pattern classification based on the CASH rule. © 2011 John Wiley & Sons A/S.

  16. The ultimate CASE (Computer-Aided Software Engineering) tool

    Energy Technology Data Exchange (ETDEWEB)

    Sharp, J.K.

    1990-01-01

    The theory and practice of information engineering is being actively developed at Sandia National Laboratories. The main output of Sandia is information. Information is created, analyzed and distributed. It is the life blood of our design laboratory. The proper management of information will have a large, positive impact on staff productivity. In order to achieve the potential benefits of shared information a commonly understood approach is needed, and the approach must be implemented in a CASE (Computer-Aided Software Engineering) tool that spans the entire life cycle of information. The commonly understood approach used at Sandia is natural language. More specifically, it is a structured subset of English. Users and system developers communicate requirements and commitments that they both understand. The approach is based upon NIAM (Nijssen's Information Analysis Methodology). In the last three years four NIAM training classes have been given at Sandia. The classes were all at the introductory level, with the latest class last October having an additional seminar highlighting successful projects. The continued growth in applications using NIAM requires an advanced class. The class will develop an information model for the Ultimate CASE Tool.'' This paper presents the requirements that have been established for the Ultimate CASE Tool'' and presents initial models. 4 refs., 1 tab.

  17. Computer-Aided Drug Design of Bioactive Natural Products.

    Science.gov (United States)

    Prachayasittikul, Veda; Worachartcheewan, Apilak; Shoombuatong, Watshara; Songtawee, Napat; Simeon, Saw; Prachayasittikul, Virapong; Nantasenamat, Chanin

    2015-01-01

    Natural products have been an integral part of sustaining civilizations because of their medicinal properties. Past discoveries of bioactive natural products have relied on serendipity, and these compounds serve as inspiration for the generation of analogs with desired physicochemical properties. Bioactive natural products with therapeutic potential are abundantly available in nature and some of them are beyond exploration by conventional methods. The effectiveness of computational approaches as versatile tools for facilitating drug discovery and development has been recognized for decades, without exception, in the case of natural products. In the post-genomic era, scientists are bombarded with data produced by advanced technologies. Thus, rendering these data into knowledge that is interpretable and meaningful becomes an essential issue. In this regard, computational approaches utilize the existing data to generate knowledge that provides valuable understanding for addressing current problems and guiding the further research and development of new natural-derived drugs. Furthermore, several medicinal plants have been continuously used in many traditional medicine systems since antiquity throughout the world, and their mechanisms have not yet been elucidated. Therefore, the utilization of computational approaches and advanced synthetic techniques would yield great benefit to improving the world's health population and well-being.

  18. Developing a Participatory Pedagogical and Multidisciplinary Approach for Integrating HIV/AIDS into University Curriculum

    Science.gov (United States)

    Mulwo, Abraham Kiprop; Chemai, Lemmy

    2015-01-01

    The current framework for integrating HIV/AIDS into university curriculum is mainly informed by the need to make HIV/AIDS education relevant to specific disciplines, and to equip graduates with necessary skills to respond to HIV/AIDS in their professional capacities. This strategy mainly emphasizes content and knowledge and largely ignores the…

  19. Teaching Cardiovascular Integrations with Computer Laboratories.

    Science.gov (United States)

    Peterson, Nils S.; Campbell, Kenneth B.

    1985-01-01

    Describes a computer-based instructional unit in cardiovascular physiology. The program (which employs simulated laboratory experimental techniques with a problem-solving format is designed to supplement an animal laboratory and to offer students an integrative approach to physiology through use of microcomputers. Also presents an overview of the…

  20. Integrating Computer-Mediated Communication Strategy Instruction

    Science.gov (United States)

    McNeil, Levi

    2016-01-01

    Communication strategies (CSs) play important roles in resolving problematic second language interaction and facilitating language learning. While studies in face-to-face contexts demonstrate the benefits of communication strategy instruction (CSI), there have been few attempts to integrate computer-mediated communication and CSI. The study…

  1. Review of Multi-Criteria Decision Aid for Integrated Sustainability Assessment of Urban Water Systems - MCEARD

    Science.gov (United States)

    Integrated sustainability assessment is part of a new paradigm for urban water decision making. Multi-criteria decision aid (MCDA) is an integrative framework used in urban water sustainability assessment, which has a particular focus on utilising stakeholder participation. Here ...

  2. Review of Multi-Criteria Decision Aid for Integrated Sustainability Assessment of Urban Water Systems - MCEARD

    Science.gov (United States)

    Integrated sustainability assessment is part of a new paradigm for urban water decision making. Multi-criteria decision aid (MCDA) is an integrative framework used in urban water sustainability assessment, which has a particular focus on utilising stakeholder participation. Here ...

  3. Discuss the Development of Computer-Aided Industrial Design Technology

    Directory of Open Access Journals (Sweden)

    Jun Yao

    2013-01-01

    Full Text Available The direction of the development of the industrial design gradually approaches mechanical-electrical integration and informational and electronic products. With an increasing improvement of its technical content, and better social economic conditions, peoples consumption concept are getting more and more different. Consumer concerns not just the functionality and quality of the product, more and more people are starting to focus on the appearance of the product, degree of innovation, environmental protection, and so on, which brings a higher degree of difficulty to the industrial technology. It is because the increasing demands of people and the industrial design, many scholars are increasingly concerned about the industrial design in recent years. With the continuous development of computer technology, a wide variety of hardware and software are developed, and a variety of ever-changing technologies are attracting the industrial design talents as well.

  4. Computer-aided methods of determining thyristor thermal transients

    Energy Technology Data Exchange (ETDEWEB)

    Lu, E.; Bronner, G.

    1988-08-01

    An accurate tracing of the thyristor thermal response is investigated. This paper offers several alternatives for thermal modeling and analysis by using an electrical circuit analog: topological method, convolution integral method, etc. These methods are adaptable to numerical solutions and well suited to the use of the digital computer. The thermal analysis of thyristors was performed for the 1000 MVA converter system at the Princeton Plasma Physics Laboratory. Transient thermal impedance curves for individual thyristors in a given cooling arrangement were known from measurements and from manufacturer's data. The analysis pertains to almost any loading case, and the results are obtained in a numerical or a graphical format. 6 refs., 9 figs.

  5. Pilot decision making in a computer-aided flight management situation

    Science.gov (United States)

    Chu, Y. Y.; Rouse, W. B.

    1978-01-01

    An experimental representation of a computer-aided multi-task flight management situation has been developed. A computer aiding program was implemented to serve as a back-up decision maker. An experiment was conducted with a balanced design of several subject runs for different workload levels. This was achieved using three levels of subsystem event arrival rates, three levels of control task involvement, and three levels of availability of computer aiding. Experimental results compared quite favorably with those from a computer simulation which employed a queueing model. It was shown that the aiding had enhanced system performance as well as subjective ratings, and that the adaptive aiding policy further reduced subsystem delay.

  6. Computer-aided pulmonary image analysis in small animal models

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Ziyue; Mansoor, Awais; Mollura, Daniel J. [Center for Infectious Disease Imaging (CIDI), Radiology and Imaging Sciences, National Institutes of Health (NIH), Bethesda, Maryland 32892 (United States); Bagci, Ulas, E-mail: ulasbagci@gmail.com [Center for Research in Computer Vision (CRCV), University of Central Florida (UCF), Orlando, Florida 32816 (United States); Kramer-Marek, Gabriela [The Institute of Cancer Research, London SW7 3RP (United Kingdom); Luna, Brian [Microfluidic Laboratory Automation, University of California-Irvine, Irvine, California 92697-2715 (United States); Kubler, Andre [Department of Medicine, Imperial College London, London SW7 2AZ (United Kingdom); Dey, Bappaditya; Jain, Sanjay [Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 (United States); Foster, Brent [Department of Biomedical Engineering, University of California-Davis, Davis, California 95817 (United States); Papadakis, Georgios Z. [Radiology and Imaging Sciences, National Institutes of Health (NIH), Bethesda, Maryland 32892 (United States); Camp, Jeremy V. [Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky 40202 (United States); Jonsson, Colleen B. [National Institute for Mathematical and Biological Synthesis, University of Tennessee, Knoxville, Tennessee 37996 (United States); Bishai, William R. [Howard Hughes Medical Institute, Chevy Chase, Maryland 20815 and Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 (United States); Udupa, Jayaram K. [Medical Image Processing Group, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States)

    2015-07-15

    Purpose: To develop an automated pulmonary image analysis framework for infectious lung diseases in small animal models. Methods: The authors describe a novel pathological lung and airway segmentation method for small animals. The proposed framework includes identification of abnormal imaging patterns pertaining to infectious lung diseases. First, the authors’ system estimates an expected lung volume by utilizing a regression function between total lung capacity and approximated rib cage volume. A significant difference between the expected lung volume and the initial lung segmentation indicates the presence of severe pathology, and invokes a machine learning based abnormal imaging pattern detection system next. The final stage of the proposed framework is the automatic extraction of airway tree for which new affinity relationships within the fuzzy connectedness image segmentation framework are proposed by combining Hessian and gray-scale morphological reconstruction filters. Results: 133 CT scans were collected from four different studies encompassing a wide spectrum of pulmonary abnormalities pertaining to two commonly used small animal models (ferret and rabbit). Sensitivity and specificity were greater than 90% for pathological lung segmentation (average dice similarity coefficient > 0.9). While qualitative visual assessments of airway tree extraction were performed by the participating expert radiologists, for quantitative evaluation the authors validated the proposed airway extraction method by using publicly available EXACT’09 data set. Conclusions: The authors developed a comprehensive computer-aided pulmonary image analysis framework for preclinical research applications. The proposed framework consists of automatic pathological lung segmentation and accurate airway tree extraction. The framework has high sensitivity and specificity; therefore, it can contribute advances in preclinical research in pulmonary diseases.

  7. Computational thermodynamics aided design of novel ferritic alloys

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Ying [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Chen, Tianyi [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Tan, Lizhen [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-06-30

    With the aid of computational thermodynamics, Ni was identified to suppress the liquidus temperature of Fe2Zr and four Fe-Cr-Ni-Zr alloys were designed to study the Ni effect on the phase stability of Fe2Zr laves_phase. These alloys were fabricated through traditional arc-metling, followed by annealing at 1000 C for 336 hours and 700 C for 1275 hours. The microstructure were examined and characterized by SEM BSE image, EDS compositional mapping and point scan, XRD and TEM analysis. The major results were summarized below: 1)For investigated alloys with 12wt% Cr, 3~6wt% Zr and 3~9 wt%Ni, the phases in equilibrium with the BCC phase are C15_Laves phase, Fe23Zr6 phase. The volume fraction of intermetallic phases increases with Ni and Zr contents. 2)Instead of (Fe,Cr)2Zr C14_Laves phase, Ni stabilizes the C15_Laves structure in Fe-Cr-Ni-Zr alloys by substituting Fe and Cr atoms with Ni atoms in the first sublattice. 3)Fe23Zr6, that is metastable in the Fe-Cr-Zr ternary, is also stabilized by Ni addition. 4)Ni7Zr2 phase was observed in samples with high Ni/Zr ratio. Extensive solubility of Fe was identified in the phase. The microstructural and composition results obtained from this study will be incorportated into the the Fe-Cr-Ni-Zr database. The current samples will be subjected to ion irradiaition to be compared with those results for Fe-Cr-Zr alloys. Additional alloys will be designed to form (Fe,Cr,Ni)2Zr nanoprecipitates for further studies.

  8. Accuracy of Stokes integration for geoid computation

    Science.gov (United States)

    Ismail, Zahra; Jamet, Olivier; Altamimi, Zuheir

    2014-05-01

    Geoid determination by remove-compute-restore (RCR) technique involves the application of Stokes's integral on reduced gravity anomalies. Reduced gravity anomalies are obtained through interpolation after removing low degree gravity signal from space spherical harmonic model and high frequency from topographical effects and cover a spectre ranging from degree 150-200. Stokes's integral is truncated to a limited region around the computation point producing an error that will be reducing by a modification of Stokes's kernel. We study Stokes integral accuracy on synthetic signal of various frequency ranges, produced with EGM2008 spherical harmonic coefficients up to degree 2000. We analyse the integration error according to the frequency range of signal, the resolution of gravity anomaly grid and the radius of Stokes integration. The study shows that the behaviour of the relative errors is frequency independent. The standard Stokes kernel is though insufficient to produce 1cm geoid accuracy without a removal of the major part of the gravity signal up to degree 600. The Integration over an area of radius greater than 3 degree does not improve accuracy improvement. The results are compared to a similar experiment using the modified Stokes kernel formula (Ellmann2004, Sjöberg2003). References: Ellmann, A. (2004) The geoid for the Baltic countries determined by least-squares modification of Stokes formula. Sjöberg, LE (2003). A general model of modifying Stokes formula and its least-squares solution Journal of Geodesy, 77. 459-464.

  9. Computer-Aided Prototyping Systems (CAPS) within the software acquisition process: a case study

    OpenAIRE

    Ellis, Mary Kay

    1993-01-01

    Approved for public release; distribution is unlimited This thesis provides a case study which examines the benefits derived from the practice of computer-aided prototyping within the software acquisition process. An experimental prototyping systems currently in research is the Computer Aided Prototyping System (CAPS) managed under the Computer Science department of the Naval Postgraduate School, Monterey, California. This thesis determines the qualitative value which may be realized by ...

  10. CADMIO: computer aided design for medical information objects.

    Science.gov (United States)

    Minarelli, D V; Ferri, F; Pisanelli, D M; Ricci, F L; Tittarelli, F

    1995-01-01

    The growth of the computational capability and the tools of graphic software is nowadays available in an integrated manner into the development environments, thus permitting the realization of tool kits capable of handling information that is complex and of different kinds such as the typical medical information. This has given a great impulse to the creation of electronic medical folders joining together with new and stimulating functionality with respect to the usual paper document [1]. In the present work, we propose a tool capable of defining a multimedia electronic medical folder and representing its architecture through a layout that is formed on the basis of the particular data types to be handled. This tool is capable of providing an integrated view of data that, even though they are close in cognitive sense, are often stored and represented apart in the practice. Different approaches to the browsing feature are giving within the system, thus the user can personalize the way of viewing the information stored into the folder or can let the system guide the browsing.

  11. Computer Aided Design of Polygalacturonase II from Aspergillus niger

    Directory of Open Access Journals (Sweden)

    Ibrahim Ali Noorbatcha

    2011-12-01

    Full Text Available Pectin is a complex polysaccharide found in the cell walls of plants and consisting mainly of esterified D-galacturonic acid resides in α-(1-4 chain. In production of fruit juice, pectin contributes to fruit juice viscosity, thereby reducing the juice production and increasing the filtration time. Polygalacturonase improves the juice production process by rapid degradation of pectin. In this project we have designed a novel polygalacturonase enzyme using computer aided design approaches. The three dimension structure of polygalacturonase is first modeled on the basis of the known crystal structure. The active site in this enzyme is identified by manual and automated docking methods. Lamarckian genetic algorithm is used for automated docking and the active site is validated by comparing with existing experimental data. This is followed by in silico mutations of the enzymes and the automated docking process is repeated using the mutant enzymes. The strength of the binding of the ligands inside the active site is evaluated by computing the binding score using Potential Mean Force (PMF method. The in silico mutations R256Q and K258N are found to decrease the binding strength of the ligand at the active site, indicating lowering of enzyme activity, which is consistent with the experimental results. Hence in silico mutations can be used to design new polygalacturonase enzymes with improved enzyme activity.ABSTRAK: Pektin adalah polisakarida kompleks yang terdapat di dalam dinding sel tumbuhan dan sebahagian besarnya terdiri daripada asid D-galakturonik terester yang ditemui di dalam rantaian α-(1-4. Dalam penghasilan jus buah-buahan, pektin menyumbang dalam kepekatan jus buah-buahan, di mana ia mengurangkan penghasilan jus dan menambahkan masa penapisan. Poligalakturonase meningkatkan proses penghasilan jus dengan pemecahan pektin dengan cepat. Dalam projek ini, kami telah merangka satu enzim poligalakturonase baru dengan menggunakan pendekatan reka

  12. Computer-aided diagnosis of prostate cancer with emphasis on ultrasound-based approaches: a review.

    Science.gov (United States)

    Moradi, Mehdi; Mousavi, Parvin; Abolmaesumi, Purang

    2007-07-01

    This paper reviews the state of the art in computer-aided diagnosis of prostate cancer and focuses, in particular, on ultrasound-based techniques for detection of cancer in prostate tissue. The current standard procedure for diagnosis of prostate cancer, i.e., ultrasound-guided biopsy followed by histopathological analysis of tissue samples, is invasive and produces a high rate of false negatives resulting in the need for repeated trials. It is against these backdrops that the search for new methods to diagnose prostate cancer continues. Image-based approaches (such as MRI, ultrasound and elastography) represent a major research trend for diagnosis of prostate cancer. Due to the integration of ultrasound imaging in the current clinical procedure for detection of prostate cancer, we specifically provide a more detailed review of methodologies that use ultrasound RF-spectrum parameters, B-scan texture features and Doppler measures for prostate tissue characterization. We present current and future directions of research aimed at computer-aided detection of prostate cancer and conclude that ultrasound is likely to play an important role in the field.

  13. Computer Aided Design in Digital Human Modeling for Human Computer Interaction in Ergonomic Assessment: A Review

    Directory of Open Access Journals (Sweden)

    Suman Mukhopadhyay , Sanjib Kumar Das and Tania Chakraborty

    2012-12-01

    Full Text Available Research in Human-Computer Interaction (HCI hasbeen enormously successful in the area of computeraidedergonomics or human-centric designs. Perfectfit for people has always been a target for productdesign. Designers traditionally used anthropometricdimensions for 3D product design which created a lotof fitting problems when dealing with thecomplexities of the human body shapes. Computeraided design (CAD, also known as Computer aideddesign and drafting (CADD is the computertechnology used for the design processing and designdocumentation. CAD has now been used extensivelyin many applications such as automotive,shipbuilding, aerospace industries, architectural andindustrial designs, prosthetics, computer animationfor special effects in movies, advertising andtechnical manuals. As a technology, digital humanmodeling (DHM has rapidly emerged as atechnology that creates, manipulates and controlhuman representations and human-machine systemsscenes on computers for interactive ergonomic designproblem solving. DHM promises to profoundlychange how products or systems are designed, howergonomics analysis is performed, how disorders andimpairments are assessed and how therapies andsurgeries are conducted. The imperative andemerging need for the DHM appears to be consistentwith the fact that the past decade has witnessedsignificant growth in both the software systemsoffering DHM capabilities as well as the corporateadapting the technology.The authors shall dwell atlength and deliberate on how research in DHM hasfinally brought about an enhanced HCI, in thecontext of computer-aided ergonomics or humancentricdesign and discuss about future trends in thiscontext.

  14. Cuby: An integrative framework for computational chemistry.

    Science.gov (United States)

    Řezáč, Jan

    2016-05-15

    Cuby is a computational chemistry framework written in the Ruby programming language. It provides unified access to a wide range of computational methods by interfacing external software and it implements various protocols that operate on their results. Using structured input files, elementary calculations can be combined into complex workflows. For users, Cuby provides a unified and userfriendly way to automate their work, seamlessly integrating calculations carried out in different computational chemistry programs. For example, the QM/MM module allows combining methods across the interfaced programs and the builtin molecular dynamics engine makes it possible to run a simulation on the resulting potential. For programmers, it provides high-level, object-oriented environment that allows rapid development and testing of new methods and computational protocols. The Cuby framework is available for download at http://cuby4.molecular.cz. © 2016 Wiley Periodicals, Inc.

  15. Data integration aids understanding of butterfly-host plant networks

    Science.gov (United States)

    Muto-Fujita, Ai; Takemoto, Kazuhiro; Kanaya, Shigehiko; Nakazato, Takeru; Tokimatsu, Toshiaki; Matsumoto, Natsushi; Kono, Mayo; Chubachi, Yuko; Ozaki, Katsuhisa; Kotera, Masaaki

    2017-03-01

    Although host-plant selection is a central topic in ecology, its general underpinnings are poorly understood. Here, we performed a case study focusing on the publicly available data on Japanese butterflies. A combined statistical analysis of plant-herbivore relationships and taxonomy revealed that some butterfly subfamilies in different families feed on the same plant families, and the occurrence of this phenomenon more than just by chance, thus indicating the independent acquisition of adaptive phenotypes to the same hosts. We consequently integrated plant-herbivore and plant-compound relationship data and conducted a statistical analysis to identify compounds unique to host plants of specific butterfly families. Some of the identified plant compounds are known to attract certain butterfly groups while repelling others. The additional incorporation of insect-compound relationship data revealed potential metabolic processes that are related to host plant selection. Our results demonstrate that data integration enables the computational detection of compounds putatively involved in particular interspecies interactions and that further data enrichment and integration of genomic and transcriptomic data facilitates the unveiling of the molecular mechanisms involved in host plant selection.

  16. Data integration aids understanding of butterfly–host plant networks

    Science.gov (United States)

    Muto-Fujita, Ai; Takemoto, Kazuhiro; Kanaya, Shigehiko; Nakazato, Takeru; Tokimatsu, Toshiaki; Matsumoto, Natsushi; Kono, Mayo; Chubachi, Yuko; Ozaki, Katsuhisa; Kotera, Masaaki

    2017-01-01

    Although host-plant selection is a central topic in ecology, its general underpinnings are poorly understood. Here, we performed a case study focusing on the publicly available data on Japanese butterflies. A combined statistical analysis of plant–herbivore relationships and taxonomy revealed that some butterfly subfamilies in different families feed on the same plant families, and the occurrence of this phenomenon more than just by chance, thus indicating the independent acquisition of adaptive phenotypes to the same hosts. We consequently integrated plant–herbivore and plant–compound relationship data and conducted a statistical analysis to identify compounds unique to host plants of specific butterfly families. Some of the identified plant compounds are known to attract certain butterfly groups while repelling others. The additional incorporation of insect–compound relationship data revealed potential metabolic processes that are related to host plant selection. Our results demonstrate that data integration enables the computational detection of compounds putatively involved in particular interspecies interactions and that further data enrichment and integration of genomic and transcriptomic data facilitates the unveiling of the molecular mechanisms involved in host plant selection. PMID:28262809

  17. Flight evaluation of a computer aided low-altitude helicopter flight guidance system

    Science.gov (United States)

    Swenson, Harry N.; Jones, Raymond D.; Clark, Raymond

    1993-01-01

    The Flight Systems Development branch of the U.S. Army's Avionics Research and Development Activity (AVRADA) and NASA Ames Research Center have developed for flight testing a Computer Aided Low-Altitude Helicopter Flight (CALAHF) guidance system. The system includes a trajectory-generation algorithm which uses dynamic programming and a helmet-mounted display (HMD) presentation of a pathway-in-the-sky, a phantom aircraft, and flight-path vector/predictor guidance symbology. The trajectory-generation algorithm uses knowledge of the global mission requirements, a digital terrain map, aircraft performance capabilities, and precision navigation information to determine a trajectory between mission way points that seeks valleys to minimize threat exposure. This system was developed and evaluated through extensive use of piloted simulation and has demonstrated a 'pilot centered' concept of automated and integrated navigation and terrain mission planning flight guidance. This system has shown a significant improvement in pilot situational awareness, and mission effectiveness as well as a decrease in training and proficiency time required for a near terrain, nighttime, adverse weather system. AVRADA's NUH-60A STAR (Systems Testbed for Avionics Research) helicopter was specially modified, in house, for the flight evaluation of the CALAHF system. The near terrain trajectory generation algorithm runs on a multiprocessor flight computer. Global Positioning System (GPS) data are integrated with Inertial Navigation Unit (INU) data in the flight computer to provide a precise navigation solution. The near-terrain trajectory and the aircraft state information are passed to a Silicon Graphics computer to provide the graphical 'pilot centered' guidance, presented on a Honeywell Integrated Helmet And Display Sighting System (IHADSS). The system design, piloted simulation, and initial flight test results are presented.

  18. Computer-aided classification of lung nodules on computed tomography images via deep learning technique.

    Science.gov (United States)

    Hua, Kai-Lung; Hsu, Che-Hao; Hidayati, Shintami Chusnul; Cheng, Wen-Huang; Chen, Yu-Jen

    2015-01-01

    Lung cancer has a poor prognosis when not diagnosed early and unresectable lesions are present. The management of small lung nodules noted on computed tomography scan is controversial due to uncertain tumor characteristics. A conventional computer-aided diagnosis (CAD) scheme requires several image processing and pattern recognition steps to accomplish a quantitative tumor differentiation result. In such an ad hoc image analysis pipeline, every step depends heavily on the performance of the previous step. Accordingly, tuning of classification performance in a conventional CAD scheme is very complicated and arduous. Deep learning techniques, on the other hand, have the intrinsic advantage of an automatic exploitation feature and tuning of performance in a seamless fashion. In this study, we attempted to simplify the image analysis pipeline of conventional CAD with deep learning techniques. Specifically, we introduced models of a deep belief network and a convolutional neural network in the context of nodule classification in computed tomography images. Two baseline methods with feature computing steps were implemented for comparison. The experimental results suggest that deep learning methods could achieve better discriminative results and hold promise in the CAD application domain.

  19. An Intelligent Master Model of Computer Aided Process Planning for Large Complicated Stampings

    Institute of Scientific and Technical Information of China (English)

    Zheng Jinqiao; Wang Yilin; Li Zhigang

    2005-01-01

    Process planning for large complicated stampings is more complicated, illegible and multiform than that for common stampings.In this paper, an intelligent master model of computer aided process planning (CAPP) for large complicated stampings has been developed based on knowledge based engineering (KBE) and feature technology. This innovative model consists of knowledge base ( KB), process control structure (PCS), process information model (PIM), multidisciplinary design optimization (MDO), model link environment (MLE) and simulation engine (SE), to realize process planning, optimization, simulation and management integrated to complete intelligent CAPP system. In this model, KBE provides knowledge base, open architecture and knowledge reuse ability to deal with the multi-domain and multi-expression of process knowledge, and forms an integrated environment. With PIM,all the knowledge consisting of objects, constraints, experience and decision-makings is carried by object-oriented method dynamically for knowledge-reasoning. PCS makes dynamical knowledge modified and updated timely and accordingly. MLE provides sev eral methods to make CAPP system associated and integrated. SE provides a programmable mechanism to interpret simulation course and result. Meanwhile, collaborative optimization, one method of MDO, is imported to deal with the optimization distributed for multiple purposes. All these make CAPP system integrated and open to other systems, such as die design and manufacturing system.

  20. NIF Integrated Computer Controls System Description

    Energy Technology Data Exchange (ETDEWEB)

    VanArsdall, P.

    1998-01-26

    This System Description introduces the NIF Integrated Computer Control System (ICCS). The architecture is sufficiently abstract to allow the construction of many similar applications from a common framework. As discussed below, over twenty software applications derived from the framework comprise the NIF control system. This document lays the essential foundation for understanding the ICCS architecture. The NIF design effort is motivated by the magnitude of the task. Figure 1 shows a cut-away rendition of the coliseum-sized facility. The NIF requires integration of about 40,000 atypical control points, must be highly automated and robust, and will operate continuously around the clock. The control system coordinates several experimental cycles concurrently, each at different stages of completion. Furthermore, facilities such as the NIF represent major capital investments that will be operated, maintained, and upgraded for decades. The computers, control subsystems, and functionality must be relatively easy to extend or replace periodically with newer technology.

  1. NIF Integrated Computer Controls System Description

    Energy Technology Data Exchange (ETDEWEB)

    VanArsdall, P.

    1998-01-26

    This System Description introduces the NIF Integrated Computer Control System (ICCS). The architecture is sufficiently abstract to allow the construction of many similar applications from a common framework. As discussed below, over twenty software applications derived from the framework comprise the NIF control system. This document lays the essential foundation for understanding the ICCS architecture. The NIF design effort is motivated by the magnitude of the task. Figure 1 shows a cut-away rendition of the coliseum-sized facility. The NIF requires integration of about 40,000 atypical control points, must be highly automated and robust, and will operate continuously around the clock. The control system coordinates several experimental cycles concurrently, each at different stages of completion. Furthermore, facilities such as the NIF represent major capital investments that will be operated, maintained, and upgraded for decades. The computers, control subsystems, and functionality must be relatively easy to extend or replace periodically with newer technology.

  2. Predictable Restorative Work Flow for Computer-Aided Design/Computer-Aided Manufacture-Fabricated Ceramic Veneers Utilizing a Virtual Smile Design Principle.

    Science.gov (United States)

    Lin, W S; Zandinejad, A; Metz, M J; Harris, B T; Morton, D

    2015-01-01

    The purpose of this case report was to present the use of a contemporary digital photograph-assisted virtual smile design principle, an intraoral digital impression, and computer-aided design/computer-aided manufacture-fabricated lithium disilicate ceramic veneers to treat a patient with esthetic needs in the maxillary anterior region. By using the proposed digital restorative work flow, this case report demonstrated an effective communication pathway between the patient, clinician, and dental laboratory technician. Effective communication can help to achieve a more predictable and satisfactory esthetic outcome.

  3. Computer aided decision support system for cervical cancer classification

    Science.gov (United States)

    Rahmadwati, Rahmadwati; Naghdy, Golshah; Ros, Montserrat; Todd, Catherine

    2012-10-01

    Conventional analysis of a cervical histology image, such a pap smear or a biopsy sample, is performed by an expert pathologist manually. This involves inspecting the sample for cellular level abnormalities and determining the spread of the abnormalities. Cancer is graded based on the spread of the abnormal cells. This is a tedious, subjective and time-consuming process with considerable variations in diagnosis between the experts. This paper presents a computer aided decision support system (CADSS) tool to help the pathologists in their examination of the cervical cancer biopsies. The main aim of the proposed CADSS system is to identify abnormalities and quantify cancer grading in a systematic and repeatable manner. The paper proposes three different methods which presents and compares the results using 475 images of cervical biopsies which include normal, three stages of pre cancer, and malignant cases. This paper will explore various components of an effective CADSS; image acquisition, pre-processing, segmentation, feature extraction, classification, grading and disease identification. Cervical histological images are captured using a digital microscope. The images are captured in sufficient resolution to retain enough information for effective classification. Histology images of cervical biopsies consist of three major sections; background, stroma and squamous epithelium. Most diagnostic information are contained within the epithelium region. This paper will present two levels of segmentations; global (macro) and local (micro). At the global level the squamous epithelium is separated from the background and stroma. At the local or cellular level, the nuclei and cytoplasm are segmented for further analysis. Image features that influence the pathologists' decision during the analysis and classification of a cervical biopsy are the nuclei's shape and spread; the ratio of the areas of nuclei and cytoplasm as well as the texture and spread of the abnormalities

  4. Improved mammographic interpretation of masses using computer-aided diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Leichter, I. [Dept. of Electro-Optics, Jerusalem College of Technology (Israel); Fields, S.; Novak, B. [Dept. of Radiology, Hadassah University Hospital, Mt. Scopus Jerusalem (Israel); Nirel, R. [Dept. of Statistics, Hebrew University of Jerusalem, Mt. Scopus, Jerusalem (Israel); Bamberger, P. [Dept. of Electronics, Jerusalem College of Technology, Jerusalem (Israel); Lederman, R. [Department of Radiology, Hadassah University Hospital, Ein Kerem, Jerusalem (Israel); Buchbinder, S. [Department of Radiology, Montefiore Medical Center, University Hospital for the Albert Einstein College of Medicine, Bronx, New York (United States)

    2000-02-01

    The aim of this study was to evaluate the effectiveness of computerized image enhancement, to investigate criteria for discriminating benign from malignant mammographic findings by computer-aided diagnosis (CAD), and to test the role of quantitative analysis in improving the accuracy of interpretation of mass lesions. Forty sequential mammographically detected mass lesions referred for biopsy were digitized at high resolution for computerized evaluation. A prototype CAD system which included image enhancement algorithms was used for a better visualization of the lesions. Quantitative features which characterize the spiculation were automatically extracted by the CAD system for a user-defined region of interest (ROI). Reference ranges for malignant and benign cases were acquired from data generated by 214 known retrospective cases. The extracted parameters together with the reference ranges were presented to the radiologist for the analysis of 40 prospective cases. A pattern recognition scheme based on discriminant analysis was trained on the 214 retrospective cases, and applied to the prospective cases. Accuracy of interpretation with and without the CAD system, as well as the performance of the pattern recognition scheme, were analyzed using receiver operating characteristics (ROC) curves. A significant difference (p < 0.005) was found between features extracted by the CAD system for benign and malignant cases. Specificity of the CAD-assisted diagnosis improved significantly (p < 0.02) from 14 % for the conventional assessment to 50 %, and the positive predictive value increased from 0.47 to 0.62 (p < 0.04). The area under the ROC curve (A{sub z}) increased significantly (p < 0.001) from 0.66 for the conventional assessment to 0.81 for the CAD-assisted analysis. The A{sub z} for the results of the pattern recognition scheme was higher (0.95). The results indicate that there is an improved accuracy of diagnosis with the use of the mammographic CAD system above that

  5. Integrative Genomics and Computational Systems Medicine

    Energy Technology Data Exchange (ETDEWEB)

    McDermott, Jason E.; Huang, Yufei; Zhang, Bing; Xu, Hua; Zhao, Zhongming

    2014-01-01

    The exponential growth in generation of large amounts of genomic data from biological samples has driven the emerging field of systems medicine. This field is promising because it improves our understanding of disease processes at the systems level. However, the field is still in its young stage. There exists a great need for novel computational methods and approaches to effectively utilize and integrate various omics data.

  6. Implementation of a tolerance model in a computer aided design and inspection system

    Directory of Open Access Journals (Sweden)

    R. Hunter

    2006-04-01

    Full Text Available Purpose: Purpose of this paper is present a detailed framework to integrate the Computer Aided Design (CAD and Inspection (CAI systems through the integration of the Geometric Dimensioning and Tolerancing (GD&T with the inspection process in coordinate measuring machines (CMMs.Design/methodology/approach: The approach used to develop a prototype of a Knowledge Based System (KBS applied to inspection process establishes a new methodology for integrate the geometric dimensioning and tolerancing (GD&T. The integration is achieved through the definition of the knowledge units for functional properties of GD&T, inspection resources and inspection operations in a common knowledge model. The manufacturing and processing applications are the main topics approach of this paper.Findings: The findings are focused in modeling the features and interactions between knowledge units associated to topology, geometry and tolerances with the inspection process activities. The implementation of the product knowledge model is presented in a computer platform that extracts and represents the GD&T information in a CAI system.Research limitations/implications: The implications are focused on the automation of the inspection process in a KBS application. The future research is focused on the use of artificial intelligent technique, such as genetic algorithms and neural networks, to optimize the time to execute the inspection process.Practical implications: The main outcomes and implication of the KBS prototype application are focused on the reduction of the time spend to develop the inspection process. This KBS application provides the needed information to elaborate this process without the human interface.Originality/value: The original value of this paper is the integration of the design and inspection specification in a unique prototype application. The knowledge model has been defined in a common modeling language (UML and can be implemented in different

  7. Computers in engineering 1983; Proceedings of the International Conference and Exhibit, Chicago, IL, August 7-11, 1983. Volume 1 - Computer-aided design, manufacturing, and simulation

    Science.gov (United States)

    Cokonis, T. J.

    The papers presented in this volume provide examples of the impact of computers on present engineering practice and indicate some future trends in computer-aided design, manufacturing, and simulation. Topics discussed include computer-aided design of turbine cycle configuration, managing and development of engineering computer systems, computer-aided manufacturing with robots in the automotive industry, and computer-aided design/analysis techniques of composite materials in the cure phase. Papers are also presented on computer simulation of vehicular propulsion systems, the performance of a hydraulic system simulator in a CAD environment, and computer simulation of hovercraft heave dynamics and control.

  8. 6th International Workshop on Computer-Aided Scheduling of Public Transport

    CERN Document Server

    Branco, Isabel; Paixão, José

    1995-01-01

    This proceedings volume consists of papers presented at the Sixth International Workshop on Computer-Aided Scheduling of Public Transpon, which was held at the Fund~lio Calouste Gulbenkian in Lisbon from July 6th to 9th, 1993. In the tradition of alternating Workshops between North America and Europe - Chicago (1975), Leeds (1980), Montreal (1983), Hamburg (1987) and again Montreal (1990), the European city of Lisbon was selected as the venue for the Workshop in 1993. As in earlier Workshops, the central theme dealt with vehicle and duty scheduling problems and the employment of operations-research-based software systems for operational planning in public transport. However, as was initiated in Hamburg in 1987, the scope of this Workshop was broadened to include topics in related fields. This fundamental alteration was an inevitable consequence of the growing demand over the last decade for solutions to the complete planning process in public transport through integrated systems. Therefore, the program of thi...

  9. A Novel Computer-Aided Approach for Parametric Investigation of Custom Design of Fracture Fixation Plates.

    Science.gov (United States)

    Chen, Xiaozhong; He, Kunjin; Chen, Zhengming

    2017-01-01

    The present study proposes an integrated computer-aided approach combining femur surface modeling, fracture evidence recover plate creation, and plate modification in order to conduct a parametric investigation of the design of custom plate for a specific patient. The study allows for improving the design efficiency of specific plates on the patients' femur parameters and the fracture information. Furthermore, the present approach will lead to exploration of plate modification and optimization. The three-dimensional (3D) surface model of a detailed femur and the corresponding fixation plate were represented with high-level feature parameters, and the shape of the specific plate was recursively modified in order to obtain the optimal plate for a specific patient. The proposed approach was tested and verified on a case study, and it could be helpful for orthopedic surgeons to design and modify the plate in order to fit the specific femur anatomy and the fracture information.

  10. A Novel Computer-Aided Approach for Parametric Investigation of Custom Design of Fracture Fixation Plates

    Science.gov (United States)

    2017-01-01

    The present study proposes an integrated computer-aided approach combining femur surface modeling, fracture evidence recover plate creation, and plate modification in order to conduct a parametric investigation of the design of custom plate for a specific patient. The study allows for improving the design efficiency of specific plates on the patients' femur parameters and the fracture information. Furthermore, the present approach will lead to exploration of plate modification and optimization. The three-dimensional (3D) surface model of a detailed femur and the corresponding fixation plate were represented with high-level feature parameters, and the shape of the specific plate was recursively modified in order to obtain the optimal plate for a specific patient. The proposed approach was tested and verified on a case study, and it could be helpful for orthopedic surgeons to design and modify the plate in order to fit the specific femur anatomy and the fracture information. PMID:28203270

  11. Computer-aided geometric modeling of the human eye and orbit.

    Science.gov (United States)

    Parshall, R F

    1991-01-01

    The author advocates, as a long-term development agenda for the profession, a shift in the working methods of medical illustrators from a two-dimensional image processing mode to a computer-aided design and drafting (CADD) mode. Existing CADD technology, which can make short work of the complex graphic construction problems of anatomical visualization, performs virtually all of its manipulations through systematic exercise of graphic geometry which illustrators tend to reduce to an intuitive, almost vestigial supplement to 2D image processing methods. The primary barrier to the immediate use of CADD is a lack of geometric database materials on anatomical component systems of the body. An on-going experimental project in modeling the human eye and orbit, utilizing a Silicon Graphics Iris workstation and Control Data Corporation's Integrated Computerized Engineering and Manufacturing (ICEM) software, exemplifies the preparatory work needed to create such database materials.

  12. Integrating HIV & AIDS education in pre-service mathematics education for social justice

    Directory of Open Access Journals (Sweden)

    Linda van Laren

    2011-01-01

    Full Text Available Since 1999, many South African education policy documents have mandated integration of HIV & AIDS education in learning areas/disciplines. Policy document research has shown that although South African politicians and managers have produced volumes of eloquent and compelling legislation regarding provision for HIV & AIDS education, little of this is translated into action. The impact of HIV & AIDS permeates the social, economic and political arenas in South Africa. Integration of HIV & AIDS education across disciplines can serve as a strategy to further the ideals of social justice. This paper focuses on how integration in the teaching and learning of Mathematics Education provides opportunities to take action for social justice. The inquiry explores the following question: How can the myth that there is 'nothing we can do' about HIV & AIDS, which is linked to social justice issues, be addressed through integration of HIV & AIDS education in Mathematics pre-service teacher education? Drawing on self-study, the work of a Mathematics teacher educator who worked with pre-service teachers to integrate HIV & AIDS education at a higher education institution is described. By considering integration of HIV & AIDS education in Mathematics Education and taking action it is possible to develop strategies which directly relate to social justice.

  13. Computer Simulation Modeling: A Method for Predicting the Utilities of Alternative Computer-Aided Treat Evaluation Algorithms

    Science.gov (United States)

    1990-09-01

    0 Technical Report 911 D~i. FiLE COPY Computer Simulation Modeling : A Method for Predicting the Utilities of Alternative Computer-Aided Threat...63007A 793 1202 HI 11. TITLE (Include Security Classification) Computer Simulation Modeling : A Method for Predicting the Utilities of Alternative...SECURITY CLASSIFICATION OF THIS PAGE("wn Data Entered) ii Technical Report 911 Computer Simulation Modeling : A Method for Predicting the Utilities of

  14. AIDS

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/000594.htm HIV/AIDS To use the sharing features on this page, ... immunodeficiency virus (HIV) is the virus that causes AIDS. When a person becomes infected with HIV, the ...

  15. Computer-Aided psychotherapy for anxiety disorders: A meta-analytic review

    NARCIS (Netherlands)

    Cuijpers, P.; Marks, I.M.; Straten, van A.; Cavanagh, K; Gega, L.; Andersson, G.

    2009-01-01

    Computer-aided psychotherapy (CP) is said to (1) be as effective as face-to-face psychotherapy, while requiring less therapist time, for anxiety disorder sufferers, (2) speed access to care, and (3) save traveling time. CP may be delivered on stand-alone or Internet-linked computers, palmtop compute

  16. Virtual Reality versus Computer-Aided Exposure Treatments for Fear of Flying

    Science.gov (United States)

    Tortella-Feliu, Miquel; Botella, Cristina; Llabres, Jordi; Breton-Lopez, Juana Maria; del Amo, Antonio Riera; Banos, Rosa M.; Gelabert, Joan M.

    2011-01-01

    Evidence is growing that two modalities of computer-based exposure therapies--virtual reality and computer-aided psychotherapy--are effective in treating anxiety disorders, including fear of flying. However, they have not yet been directly compared. The aim of this study was to analyze the efficacy of three computer-based exposure treatments for…

  17. Virtual Reality versus Computer-Aided Exposure Treatments for Fear of Flying

    Science.gov (United States)

    Tortella-Feliu, Miquel; Botella, Cristina; Llabres, Jordi; Breton-Lopez, Juana Maria; del Amo, Antonio Riera; Banos, Rosa M.; Gelabert, Joan M.

    2011-01-01

    Evidence is growing that two modalities of computer-based exposure therapies--virtual reality and computer-aided psychotherapy--are effective in treating anxiety disorders, including fear of flying. However, they have not yet been directly compared. The aim of this study was to analyze the efficacy of three computer-based exposure treatments for…

  18. Computing Fourier integral operators with caustics

    Science.gov (United States)

    Caday, Peter

    2016-12-01

    Fourier integral operators (FIOs) have widespread applications in imaging, inverse problems, and PDEs. An implementation of a generic algorithm for computing FIOs associated with canonical graphs is presented, based on a recent paper of de Hoop et al. Given the canonical transformation and principal symbol of the operator, a preprocessing step reduces application of an FIO approximately to multiplications, pushforwards and forward and inverse discrete Fourier transforms, which can be computed in O({N}n+(n-1)/2{log}N) time for an n-dimensional FIO. The same preprocessed data also allows computation of the inverse and transpose of the FIO, with identical runtime. Examples demonstrate the algorithm’s output, and easily extendible MATLAB/C++ source code is available from the author.

  19. Computer aided production planning - SWZ system of order verification

    Science.gov (United States)

    Krenczyk, D.; Skolud, B.

    2015-11-01

    SWZ (System of order verification) is a computer implementation of the methodology that support fast decision making on the acceptability of a production order, which allows to determine not the best possible solution, but admissible solution that is possible to find in an acceptable time (feasible solution) and acceptable due to the existing constraints. The methodology uses the propagation of constraints techniques and reduced to test a sequence of arbitrarily selected conditions. Fulfilment of all the conditions (the conjunction) provides the ability to perform production orders. In the paper examples of the application of SWZ system comprising the steps of planning and control is presented. The obtained results allowing the determination of acceptable production flow in the system - determination of the manufacturing system parameters those that ensure execution of orders in time under the resource constraints. SWZ also allows to generate the dispatching rules as a sequence of processing operations for each production resource, performed periodically during the production flow in the system. Furthermore the example of SWZ and simulation system integration is shown. SWZ has been enhanced with a module generating files containing the script code of the system model using the internal language of simulation and visualization system.

  20. Computer aided taxonomy (CAT): Approach for understanding systematics of marine biota

    Digital Repository Service at National Institute of Oceanography (India)

    Chavan, V.S.; Kavlekar, D.P.; Chandramohan, D.

    Computer aided taconomy (CAT) is gaining importance day by day. In order to familiarise the taxonomy and its continuing usage an attempt has made to develop a module for knowing the systematics of organisms and to generate automatic numerical code...

  1. Computer-aided Framework for Design of Pure, Mixed and Blended Products

    DEFF Research Database (Denmark)

    2015-01-01

    This paper presents a framework for computer-aided design of pure, mixed and blended chemical based products. The framework is a systematic approach to convert a Computer-aided Molecular, Mixture and Blend Design (CAMbD) formulation, based on needs and target properties, into a mixed integer non-......-linear program (MINLP). TheMINLP is sequentially solved through a decomposed optimization approach to solve the possibly large MINLP in a smaller set of sub-problems. The framework application is highlighted through a solvent design case study.......This paper presents a framework for computer-aided design of pure, mixed and blended chemical based products. The framework is a systematic approach to convert a Computer-aided Molecular, Mixture and Blend Design (CAMbD) formulation, based on needs and target properties, into a mixed integer non...

  2. Computer-aided Framework for Design of Pure, Mixed and Blended Products

    DEFF Research Database (Denmark)

    Cignitti, Stefano; Zhang, Lei; Gani, Rafiqul

    2015-01-01

    Design of novel chemical products with process and application considerations is an emerging topic in thefield of chemical and biochemical engineering. Methods, such as Computer Aided Molecular Design(CAMD) [1] and Computer-aided Mixture and Blend Design (CAMbD) [2], provide the possibility of de...... a solvent design case study.......Design of novel chemical products with process and application considerations is an emerging topic in thefield of chemical and biochemical engineering. Methods, such as Computer Aided Molecular Design(CAMD) [1] and Computer-aided Mixture and Blend Design (CAMbD) [2], provide the possibility...... of designing such products. However, these product design problems can quickly become large and difficult, if not infeasible, to solve through mathematical optimization. In addition, considerations of process,application, special product attributes, economic feasibility, environmental and sustainability...

  3. Research on the Course Integration of "Interior Design Drawing" and "Computer Aided Design" in Higher Vo-cational Colleges%高职“室内设计制图”与“计算机辅助设计”课程整合研究

    Institute of Scientific and Technical Information of China (English)

    刘静

    2016-01-01

    针对当前高职艺术设计类专业课程“室内设计制图”和“计算机辅助设计”的教学现状,并结合近年来在室内设计、环境艺术设计专业教学中的经验,提出将此两门课程合并整合为一门课程(“计算机辅助艺术设计(建筑 CAD)”)的教学改革思路,并在教学内容、教学方法和考核方法等方面做了改革调整。这种在学习室内设计理论制图的同时又掌握绘图软件的实践应用技能,教学内容交互渗透,利于学生知识的加深和技能的培养。%According to the present status of higher vocational teaching in art and design professional courses "Interior Design Drawing"and"Computer Aided Design", and combined with re-cent years' experience in the professional teaching of interior de-sign and environmental art design, this paper puts forward the teaching reform idea of establishing a new course named"Com-puter Aided Art Design (CAD for Building)" which integrates"Interior Design Drawing" with "Computer Aided Design". And new rules on the teaching content, teaching methods, assessment methods and other aspects of the new course were established, so that students can master the AutoCAD drawing practical skills while learning the knowledge of interior design drawing theory. This teaching mode not only can impact the theory and practice of teaching interactive permeation, but also can make the practice training in time to keep up with the theory of teaching, which is helpful to students' knowledge deepening and skills training.

  4. Progress of the Computer-Aided Engineering of Electric Drive Vehicle Batteries (CAEBAT) (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Pesaran, A. A.; Han, T.; Hartridge, S.; Shaffer, C.; Kim, G. H.; Pannala, S.

    2013-06-01

    This presentation, Progress of Computer-Aided Engineering of Electric Drive Vehicle Batteries (CAEBAT) is about simulation and computer-aided engineering (CAE) tools that are widely used to speed up the research and development cycle and reduce the number of build-and-break steps, particularly in the automotive industry. Realizing this, DOE?s Vehicle Technologies Program initiated the CAEBAT project in April 2010 to develop a suite of software tools for designing batteries.

  5. Computer-Aided Transformation of PDE Models: Languages, Representations, and a Calculus of Operations

    Science.gov (United States)

    2016-01-05

    Computer-aided transformation of PDE models: languages, representations, and a calculus of operations A domain-specific embedded language called...languages, representations, and a calculus of operations Report Title A domain-specific embedded language called ibvp was developed to model initial...Computer-aided transformation of PDE models: languages, representations, and a calculus of operations 1 Vision and background Physical and engineered systems

  6. Advanced Methods for the Computer-Aided Diagnosis of Lesions in Digital Mammograms

    Science.gov (United States)

    2000-07-01

    classification of mammographic mass lesions. Radiology 213: 200, 1999. " Nishikawa R, Giger ML, Yarusso L, Kupinski M, Baehr A, Venta L,: Computer-aided...detection of mass lesions in digital mammography using radial gradient index filtering. Radiology 213: 229, 1999. " Maloney M, Huo Z, Giger ML, Venta L...Nishikawa R, Huo Z, Jiang Y, Venta L, Doi K: Computer-aided diagnosis (CAD) in breast imaging. Radiology 213: 507, 1999. -Final Report DAMD 17-96-1-6058 19

  7. Computer-aided classification of lung nodules on computed tomography images via deep learning technique

    Directory of Open Access Journals (Sweden)

    Hua KL

    2015-08-01

    Full Text Available Kai-Lung Hua,1 Che-Hao Hsu,1 Shintami Chusnul Hidayati,1 Wen-Huang Cheng,2 Yu-Jen Chen3 1Department of Computer Science and Information Engineering, National Taiwan University of Science and Technology, 2Research Center for Information Technology Innovation, Academia Sinica, 3Department of Radiation Oncology, MacKay Memorial Hospital, Taipei, Taiwan Abstract: Lung cancer has a poor prognosis when not diagnosed early and unresectable lesions are present. The management of small lung nodules noted on computed tomography scan is controversial due to uncertain tumor characteristics. A conventional computer-aided diagnosis (CAD scheme requires several image processing and pattern recognition steps to accomplish a quantitative tumor differentiation result. In such an ad hoc image analysis pipeline, every step depends heavily on the performance of the previous step. Accordingly, tuning of classification performance in a conventional CAD scheme is very complicated and arduous. Deep learning techniques, on the other hand, have the intrinsic advantage of an automatic exploitation feature and tuning of performance in a seamless fashion. In this study, we attempted to simplify the image analysis pipeline of conventional CAD with deep learning techniques. Specifically, we introduced models of a deep belief network and a convolutional neural network in the context of nodule classification in computed tomography images. Two baseline methods with feature computing steps were implemented for comparison. The experimental results suggest that deep learning methods could achieve better discriminative results and hold promise in the CAD application domain. Keywords: nodule classification, deep learning, deep belief network, convolutional neural network

  8. Computer-based learning--an aid to successful teaching of pharmacology?

    Science.gov (United States)

    E Hughes, Ian

    2002-07-01

    Various types of software have been developed for use in pharmacology courses. These include: simple drill (question and answer) software; electronic books; video material; tutorial type programs; simulations; and electronic learning environments for course organisation and delivery. These different types of software can be used in different ways to achieve very different learning objectives and gains in teaching efficiency. For example, software can be used: in tutorial and small group teaching; in lectures; to better prepare students for practical work; as a replacement for practicals; to provide options within a limited course structure; to supplement lectures and enable students to work at their own pace; to provide ongoing access to self-assessment throughout a course; to aid distance learning; as remedial teaching and to extend the student learning experience in areas which are too expensive or too time consuming or for which staff expertise does not exist. Evidence indicates that it is insufficient simply to make computer based learning material available to students. Like a laboratory class, it must be fully integrated into a module if real benefits are to be obtained. Students need to be taught how to learn from computer-based learning materials and how to integrate this learning tool in their learning strategy. Teachers need to be supported not only with information about the availability of software but, equally importantly, about how it can be integrated into modules. We are all delivering teaching and facilitating learning in a changing environment and subject to a variety of increasing pressures. It may well be that computer based learning materials may help to maintain a high quality of pharmacology teaching within this changing environment but we need more pedagogical research at the discipline level to establish how this can best be done.

  9. Analytical Design Package (ADP2): A computer aided engineering tool for aircraft transparency design

    Science.gov (United States)

    Wuerer, J. E.; Gran, M.; Held, T. W.

    1994-01-01

    The Analytical Design Package (ADP2) is being developed as a part of the Air Force Frameless Transparency Program (FTP). ADP2 is an integrated design tool consisting of existing analysis codes and Computer Aided Engineering (CAE) software. The objective of the ADP2 is to develop and confirm an integrated design methodology for frameless transparencies, related aircraft interfaces, and their corresponding tooling. The application of this methodology will generate high confidence for achieving a qualified part prior to mold fabrication. ADP2 is a customized integration of analysis codes, CAE software, and material databases. The primary CAE integration tool for the ADP2 is P3/PATRAN, a commercial-off-the-shelf (COTS) software tool. The open architecture of P3/PATRAN allows customized installations with different applications modules for specific site requirements. Integration of material databases allows the engineer to select a material, and those material properties are automatically called into the relevant analysis code. The ADP2 materials database will be composed of four independent schemas: CAE Design, Processing, Testing, and Logistics Support. The design of ADP2 places major emphasis on the seamless integration of CAE and analysis modules with a single intuitive graphical interface. This tool is being designed to serve and be used by an entire project team, i.e., analysts, designers, materials experts, and managers. The final version of the software will be delivered to the Air Force in Jan. 1994. The Analytical Design Package (ADP2) will then be ready for transfer to industry. The package will be capable of a wide range of design and manufacturing applications.

  10. Aiding human reliance decision making using computational models of trust

    NARCIS (Netherlands)

    Maanen, P.P. van; Klos, T.; Dongen, C.J. van

    2007-01-01

    This paper involves a human-agent system in which there is an operator charged with a pattern recognition task, using an automated decision aid. The objective is to make this human-agent system operate as effectively as possible. Effectiveness is gained by an increase of appropriate reliance on the

  11. Computer aided composition by means of interactive GP

    DEFF Research Database (Denmark)

    Ando, Daichi; Dahlstedt, Palle; Nordahl, Mats G.

    2006-01-01

    Research on the application of Interactive Evolutionary Computation (IEC) to the field of musical computation has been improved in recent years, marking an interesting parallel to the current trend of applying human characteristics or sensitivities to computer systems. However, past techniques...

  12. Computer-Assisted Placement: Effective Aid or Paper Albatross?

    Science.gov (United States)

    Sampson, James P.

    1978-01-01

    A short time ago, the computer was a concept of the future which scared many and amazed even more. Now a reality, the computer has become as common on the placement front as the interview. The computer's value to placement is discussed. (Author)

  13. DeepCAD: A Computer-Aided Diagnosis System for Mammographic Masses Using Deep Invariant Features

    Directory of Open Access Journals (Sweden)

    Qaisar Abbas

    2016-10-01

    Full Text Available The development of a computer-aided diagnosis (CAD system for differentiation between benign and malignant mammographic masses is a challenging task due to the use of extensive pre- and post-processing steps and ineffective features set. In this paper, a novel CAD system is proposed called DeepCAD, which uses four phases to overcome these problems. The speed-up robust features (SURF and local binary pattern variance (LBPV descriptors are extracted from each mass. These descriptors are then transformed into invariant features. Afterwards, the deep invariant features (DIFs are constructed in supervised and unsupervised fashion through multilayer deep-learning architecture. A fine-tuning step is integrated to determine the features, and the final decision is performed via softmax linear classifier. To evaluate this DeepCAD system, a dataset of 600 region-of-interest (ROI masses including 300 benign and 300 malignant masses was obtained from two publicly available data sources. The performance of DeepCAD system is compared with the state-of-the-art methods in terms of area under the receiver operating characteristics (AUC curve. The difference between AUC of DeepCAD and other methods is statistically significant, as it demonstrates a sensitivity (SN of 92%, specificity (SP of 84.2%, accuracy (ACC of 91.5% and AUC of 0.91. The experimental results indicate that the proposed DeepCAD system is reliable for providing aid to radiologists without the need for explicit design.

  14. Integrating network awareness in ATLAS distributed computing

    CERN Document Server

    De, K; The ATLAS collaboration; Klimentov, A; Maeno, T; Mckee, S; Nilsson, P; Petrosyan, A; Vukotic, I; Wenaus, T

    2014-01-01

    A crucial contributor to the success of the massively scaled global computing system that delivers the analysis needs of the LHC experiments is the networking infrastructure upon which the system is built. The experiments have been able to exploit excellent high-bandwidth networking in adapting their computing models for the most efficient utilization of resources. New advanced networking technologies now becoming available such as software defined networks hold the potential of further leveraging the network to optimize workflows and dataflows, through proactive control of the network fabric on the part of high level applications such as experiment workload management and data management systems. End to end monitoring of networking and data flow performance further allows applications to adapt based on real time conditions. We will describe efforts underway in ATLAS on integrating network awareness at the application level, particularly in workload management.

  15. Integrating HIV & AIDS Education in Pre-Service Mathematics Education for Social Justice

    Science.gov (United States)

    van Laren, Linda

    2011-01-01

    Since 1999, many South African education policy documents have mandated integration of HIV & AIDS education in learning areas/disciplines. Policy document research has shown that although South African politicians and managers have produced volumes of eloquent and compelling legislation regarding provision for HIV & AIDS education, little…

  16. HIV/AIDS and Employment Research: A Need for an Integrative Approach

    Science.gov (United States)

    Conyers, Liza Marie

    2008-01-01

    This article provides a reflection on the three articles that compose the Major Contribution on HIV/AIDS and employment research. It highlights the merits of the contribution in the broader context of HIV/AIDS employment research and recommends future directions for this area of inquiry, including theory integration, an investigation of HIV health…

  17. Evaluating Computer Technology Integration in a Centralized School System

    Science.gov (United States)

    Eteokleous, N.

    2008-01-01

    The study evaluated the current situation in Cyprus elementary classrooms regarding computer technology integration in an attempt to identify ways of expanding teachers' and students' experiences with computer technology. It examined how Cypriot elementary teachers use computers, and the factors that influence computer integration in their…

  18. Computer-aided design of bromelain and papain covalent immobilization

    Directory of Open Access Journals (Sweden)

    Bessy Cutiño-Avila

    2014-06-01

    Full Text Available Título en español: Diseño asistido por computadora de la inmovilización covalente de bromelina y papaína.Título corto: Computer-aided design of bromelain and papain. Abstract: Enzymes as immobilized derivatives have been widely used in Food, Agrochemical, Pharmaceutical and Biotechnological industries. Protein immobilization is probably the most used technology to improve the operational stability of these molecules. Bromelain (Ananas comosus and papain (Carica papaya are cystein proteases extensively used as immobilized biocatalyst with several applications in therapeutics, racemic mixtures resolution, affinity chromatography and others industrial scenarios. The aim of this work was to optimize the covalent immobilization of bromelain and papain via rational design of immobilized derivatives strategy (RDID and RDID1.0 program. It was determined the maximum protein quantity to immobilize, the optimum immobilization pH (in terms of functional activity retention, and the most probable configuration of the immobilized derivative and the probabilities of multipoint covalent attachment was also predicted. As support material Glyoxyl-Sepharose CL 4B was used.  The accuracy of RDID1.0 program´s prediction was demonstrated comparing with experimental results. Bromelain and papain immobilized derivatives showed desired characteristics for industrial biocatalysis, such as: elevate pH stability retaining 95% and 100% residual activity at pH 7.0 and 8.0, for bromelain and papain, respectively; high thermal stability at 30 °C retaining 90% residual activity for both immobilized enzymes; a catalytic configuration bonded by immobilization at optimal pH; and the ligand load achieved, ensures the minimization of diffusional restrictions.Key words: bromelain, covalent immobilization, immobilized derivatives, papain, rational design.Resumen: Las enzimas inmovilizadas han sido ampliamente utilizadas en las industrias Alimentaria, Agroquímica, Farmac

  19. CONTRIBUTIONS FOR DEVELOPING OF A COMPUTER AIDED LEARNING ENVIRONMENT OF DESCRIPTIVE GEOMETRY

    Directory of Open Access Journals (Sweden)

    Antonescu Ion

    2009-07-01

    Full Text Available The paper presents the authors’ contributions for developing a computer code for teaching of descriptive geometry using the computer aided learning techniques. The program was implemented using the programming interface and the 3D modeling capabilities of the AutoCAD system.

  20. Computer-Aided Detection of Polyps in CT Colonography Using Logistic Regression

    NARCIS (Netherlands)

    Van Ravesteijn, V.F.; Van Wijk, C.; Vos, F.M.; Truyen, R.; Peters, J.F.; Stoker, J.; Van Vliet, L.J.

    2010-01-01

    We present a computer-aided detection (CAD) system for computed tomography colonography that orders the polyps according to clinical relevance. TheCADsystem consists of two steps: candidate detection and supervised classification. The characteristics of the detection step lead to specific choices fo

  1. Computer aided design of prosthetic sockets for below-knee amputees.

    Science.gov (United States)

    Saunders, C G; Foort, J; Bannon, M; Lean, D; Panych, L

    1985-04-01

    A computer-aided sculpting system for use in prosthetics is described. The prosthetist's sculpting tools now consist of a computer, a graphics terminal, a mouse and an on-screen moveable cursor. Accompanied by the system software, these tools allow systematic modification of a primitive socket using techniques analogous to those used by a prosthetist working with rasps and plaster.

  2. Computer-Aided College Algebra: Learning Components that Students Find Beneficial

    Science.gov (United States)

    Aichele, Douglas B.; Francisco, Cynthia; Utley, Juliana; Wescoatt, Benjamin

    2011-01-01

    A mixed-method study was conducted during the Fall 2008 semester to better understand the experiences of students participating in computer-aided instruction of College Algebra using the software MyMathLab. The learning environment included a computer learning system for the majority of the instruction, a support system via focus groups (weekly…

  3. A Computer-Aided Self-Testing System for Biological Psychology.

    Science.gov (United States)

    Leiblum, M. D.; And Others

    1994-01-01

    Describes the production of a computer-aided, self-testing system for university students enrolled in a first-year course in biological psychology. Project aspects described include selection, acquisition and description of software; question banks and test structures; modes of use (computer or printed version); evaluation; and future plans. (11…

  4. A Computer-Aided Self-Testing System for Biological Psychology.

    Science.gov (United States)

    Leiblum, M. D.; And Others

    1994-01-01

    Describes the production of a computer-aided, self-testing system for university students enrolled in a first-year course in biological psychology. Project aspects described include selection, acquisition and description of software; question banks and test structures; modes of use (computer or printed version); evaluation; and future plans. (11…

  5. Study on computer-aided alignment method of reflective zoom systems

    Science.gov (United States)

    Zhou, Jide; Chang, Jun; Xie, Guijuan; Zhang, Ke

    2015-08-01

    Computer-aided alignment is an effective method to improve the imaging quality of high-precision, complex, and off-axis optical systems. However, how to determine the misalignment quickly, exactly and constantly is essential to the technology of computer-aided alignment. Owing to the varying optical characteristics of a zoom system, sensitivity matrices are used in the alignment rather than a single matrix. Thus, the processing of sensitivity matrices is important for the computer-aided alignment of the reflective zoom system. So, the total least squares is proposed in order to solve the problems of the numerical instability and the result inaccuracy which result from the solution of the least squares method directly. Finally, the simulant calculation is processed using the numerical analysis model established in the essay. The results demonstrate that the computation method is rational and effective.

  6. Indoor Map Aided Wi-Fi Integrated Lbs on Smartphone Platforms

    Science.gov (United States)

    Yu, C.; El-Sheimy, N.

    2017-09-01

    In this research, an indoor map aided INS/Wi-Fi integrated location based services (LBS) applications is proposed and implemented on smartphone platforms. Indoor map information together with measurements from an inertial measurement unit (IMU) and Received Signal Strength Indicator (RSSI) value from Wi-Fi are collected to obtain an accurate, continuous, and low-cost position solution. The main challenge of this research is to make effective use of various measurements that complement each other without increasing the computational burden of the system. The integrated system in this paper includes three modules: INS, Wi-Fi (if signal available) and indoor maps. A cascade structure Particle/Kalman filter framework is applied to combine the different modules. Firstly, INS position and Wi-Fi fingerprint position integrated through Kalman filter for estimating positioning information. Then, indoor map information is applied to correct the error of INS/Wi-Fi estimated position through particle filter. Indoor tests show that the proposed method can effectively reduce the accumulation positioning errors of stand-alone INS systems, and provide stable, continuous and reliable indoor location service.

  7. Computer aided composition by means of interactive GP

    DEFF Research Database (Denmark)

    Ando, Daichi; Dahlstedt, Palle; Nordahl, Mats G.

    2006-01-01

    Research on the application of Interactive Evolutionary Computation (IEC) to the field of musical computation has been improved in recent years, marking an interesting parallel to the current trend of applying human characteristics or sensitivities to computer systems. However, past techniques...... developed for IEC-based composition have not necessarily proven very effective for professional use. This is due to the large difference between data representation used by IEC and authored classical music composition. To solve this difficulties, we purpose a new IEC approach to music composition based...

  8. Use of Integrated Computational Approaches in the Search for New Therapeutic Agents.

    Science.gov (United States)

    Persico, Marco; Di Dato, Antonio; Orteca, Nausicaa; Cimino, Paola; Novellino, Ettore; Fattorusso, Caterina

    2016-09-01

    Computer-aided drug discovery plays a strategic role in the development of new potential therapeutic agents. Nevertheless, the modeling of biological systems still represents a challenge for computational chemists and at present a single computational method able to face such challenge is not available. This prompted us, as computational medicinal chemists, to develop in-house methodologies by mixing various bioinformatics and computational tools. Importantly, thanks to multi-disciplinary collaborations, our computational studies were integrated and validated by experimental data in an iterative process. In this review, we describe some recent applications of such integrated approaches and how they were successfully applied in i) the search of new allosteric inhibitors of protein-protein interactions and ii) the development of new redox-active antimalarials from natural leads.

  9. COMPUTER-AIDED FLOW METER APPLICABLE TO LOOSE MATERIALS IN THE COURSE OF PNEUMATIC TRANSPORTATION

    Directory of Open Access Journals (Sweden)

    Gulyaev Valeriy Genrihovich

    2012-07-01

    Full Text Available The article covers the issues of development and the results of the pilot testing of the contact-free meter of the two-phase flow of loose construction materials in the course of their pneumatic transportation. The flow meter designed by the author is based on the method of registration of polarization currents caused by the motion of the dielectric material within the electric field of a measurement unit integrated into the pneumatic transportation line. The registration unit is the implementation of the original technology. Its functional concept is based on the Pockels transverse effect inside the lithium niobate crystal. This electro-optical effect is characterized by minimal persistence, as the phase of the optical wave varies within the time period of 10 second, and this effect makes it possible to improve the accuracy of measurements. The flow rates is identified on the basis of one variable integral parameter, the intensity of an optical wave passing through the Pockels cell simulated by the currents of polarization of the material. The paper contains the structural pattern of the computer-aided meter of loose dielectric materials in the course of their pneumatic transportation, the system of visualization of the mass flow, and the results of the pilot testing of the proposed meter. The proposed system may represent an unbiased system of management of construction materials, consumption procedures, and warehouse processing of materials.

  10. Computer-aided methods for quantitative assessment of longitudinal changes in retinal images presenting with maculopathy

    Science.gov (United States)

    Soliz, Peter; Wilson, Mark P.; Nemeth, Sheila C.; Nguyen, Phong

    2002-05-01

    This paper presents the results from applying a computer- based methodology for making precise measurements of longitudinal changes in a patient's digital retinal images presenting with age-related macular degeneration. The digital retinal image analysis system applies recognized principles in automatic image segmentation and integrates the automation with a graphical user interface. Drusen, retinal lesions associated with age-related macular degeneration (ARMD), were segmented using a region-growing algorithm. The algorithm calculates the 76 percentile intensity in a region to provide seed points for the neighborhood-growing algorithm. Twenty-one cases were analyzed. Agreement statistics (kappa) were determined by comparing the automated results with those provided from manually derived measurements. Agreement statistics ranged from 0.49 to 0.71 for different regions of the retina. The manual analysis ground truth was performed by trained graders from the University of Wisconsin Reading Center using guidelines found in the Wisconsin Age-Related Maculopathy Degeneration Grading Scheme (WARMGS). Because of the time required, the ophthalmic graders can only grade (size, area, type) the most prominent drusen in specific regions, resulting in a small sampling of drusen lesions in the retina. The computer-based approach allows one to efficiently and comprehensively grade all of the lesions for larger numbers of images. The additional advantage, however, is in the precision and total area that can be graded with the computer-aided technology. Computer-registered longitudinal images produced a precise determination of the temporal changes in the individual lesions. This study has demonstrated a robust segmentation and registration methodology for automatic and semiautomatic detection and measurement of abnormal regions in longitudinal retinal images.

  11. Abdominal Computed tomography of 25 patients with AIDS or lymphadenopathy Syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Arrive, L.; Frija, J.; Couderc, L.J.; Clauvel, J.P.; Laval-Jeantet, M.

    1986-03-01

    An abdominal computed tomographic examination was performed to 20 patients with Acquired Immunodeficiency Syndrome (AIDS) and to 5 patients with Lymphadenopathy Syndrome (LAS). Intraabdominal lymph nodes were seen in 18 out of 20 cases of AIDS and in 5 cases of LAS. Lymph nodes have a normal size or are slightly enlarged but they are too numerous. Splenomegaly was found in 17 patients. Rectal modifications secondary to a proctitis were seen in the homosexual patients.

  12. A computer-aided drug discovery system for chemistry teaching.

    Science.gov (United States)

    Gledhill, Robert; Kent, Sarah; Hudson, Brian; Richards, W Graham; Essex, Jonathan W; Frey, Jeremy G

    2006-01-01

    The Schools Malaria Project (http://emalaria.soton.ac.uk/) brings together school students with university researchers in the hunt for a new antimalaria drug. The design challenge being offered to students is to use a distributed drug search and selection system to design potential antimalaria drugs. The system is accessed via a Web interface. This e-science project displays the results of the trials in an accessible manner, giving students an opportunity for discussion and debate both with peers and with the university contacts. The project has been implemented by using distributed computing techniques, spreading computer load over a network of machines that cross institutional boundaries, forming a grid. This provides access to greater computing power and allows a much more complex and detailed formulation of the drug design problem to be tackled for research, teaching, and learning.

  13. ASCR Cybersecurity for Scientific Computing Integrity

    Energy Technology Data Exchange (ETDEWEB)

    Piesert, Sean

    2015-02-27

    The Department of Energy (DOE) has the responsibility to address the energy, environmental, and nuclear security challenges that face our nation. Much of DOE’s enterprise involves distributed, collaborative teams; a signi¬cant fraction involves “open science,” which depends on multi-institutional, often international collaborations that must access or share signi¬cant amounts of information between institutions and over networks around the world. The mission of the Office of Science is the delivery of scienti¬c discoveries and major scienti¬c tools to transform our understanding of nature and to advance the energy, economic, and national security of the United States. The ability of DOE to execute its responsibilities depends critically on its ability to assure the integrity and availability of scienti¬c facilities and computer systems, and of the scienti¬c, engineering, and operational software and data that support its mission.

  14. Server-Aided Two-Party Computation with Simultaneous Corruption

    DEFF Research Database (Denmark)

    Cascudo Pueyo, Ignacio; Damgård, Ivan Bjerre; Ranellucci, Samuel

    We consider secure two-party computation in the client-server model where there are two adversaries that operate separately but simultaneously, each of them corrupting one of the parties and a restricted subset of servers that they interact with. We model security via the local universal composab...... composability framework introduced by Canetti and Vald and we show that information-theoretically secure two-party computation is possible if and only if there is always at least one server which remains uncorrupted....

  15. Server-Aided Two-Party Computation with Simultaneous Corruption

    DEFF Research Database (Denmark)

    Cascudo Pueyo, Ignacio; Damgård, Ivan Bjerre; Ranellucci, Samuel

    We consider secure two-party computation in the client-server model where there are two adversaries that operate separately but simultaneously, each of them corrupting one of the parties and a restricted subset of servers that they interact with. We model security via the local universal composab......We consider secure two-party computation in the client-server model where there are two adversaries that operate separately but simultaneously, each of them corrupting one of the parties and a restricted subset of servers that they interact with. We model security via the local universal...

  16. Art,Science and Technology——Computed Aided Design in Practice & How computer technology affect designer’s work

    Institute of Scientific and Technical Information of China (English)

    赵耀

    2010-01-01

    Introduction:Computing technology has developed significantly in the past few decades.It affects almost everyone in the modern society,creating new ways of communication which affects both our work and leisure activities.Particularly,in today’s world of design and technology,computer aided design is fast becoming a technologically and economically feasible reality.Most designers have accepted the fact that computer aided design plays an important role in the success of their practices,not due to it’s value as an efficient drafting and modeling tool,but also because of clients’perception that it makes sound financial sense to utilize CAD.On the other hand,many people argue that computers are not fully autonomous,they are merely unconscious digital slaves or tools of production.In addition,the abusive use of software technology would turn creative art design into a purely industrial activity.

  17. Image-based diagnostic aid for interstitial lung disease with secondary data integration

    Science.gov (United States)

    Depeursinge, Adrien; Müller, Henning; Hidki, Asmâa; Poletti, Pierre-Alexandre; Platon, Alexandra; Geissbuhler, Antoine

    2007-03-01

    Interstitial lung diseases (ILDs) are a relatively heterogeneous group of around 150 illnesses with often very unspecific symptoms. The most complete imaging method for the characterisation of ILDs is the high-resolution computed tomography (HRCT) of the chest but a correct interpretation of these images is difficult even for specialists as many diseases are rare and thus little experience exists. Moreover, interpreting HRCT images requires knowledge of the context defined by clinical data of the studied case. A computerised diagnostic aid tool based on HRCT images with associated medical data to retrieve similar cases of ILDs from a dedicated database can bring quick and precious information for example for emergency radiologists. The experience from a pilot project highlighted the need for detailed database containing high-quality annotations in addition to clinical data. The state of the art is studied to identify requirements for image-based diagnostic aid for interstitial lung disease with secondary data integration. The data acquisition steps are detailed. The selection of the most relevant clinical parameters is done in collaboration with lung specialists from current literature, along with knowledge bases of computer-based diagnostic decision support systems. In order to perform high-quality annotations of the interstitial lung tissue in the HRCT images an annotation software and its own file format is implemented for DICOM images. A multimedia database is implemented to store ILD cases with clinical data and annotated image series. Cases from the University & University Hospitals of Geneva (HUG) are retrospectively and prospectively collected to populate the database. Currently, 59 cases with certified diagnosis and their clinical parameters are stored in the database as well as 254 image series of which 26 have their regions of interest annotated. The available data was used to test primary visual features for the classification of lung tissue patterns

  18. Computer-Guided-Teaching: An Effective Aid for Group Instruction.

    Science.gov (United States)

    Hativa, Nira

    1984-01-01

    Describes a special application of the microcomputer for small and large group instruction called Computer-Guided-Teaching (CGT). Effective teaching strategies incorporated in CGT lessons are discussed, and a description of a formal geometry course illustrates their use in CGT lessons. (MBR)

  19. Computer-aided analysis of grain growth in metals

    DEFF Research Database (Denmark)

    Klimanek, P.; May, C.; Richter, H.

    1993-01-01

    Isothermal grain growth in aluminium, copper and alpha-iron was investigated experimentally at elevated temperatures and quantitatively interpreted by computer simulation on the base of a statistical model described in [4,5,6]. As it is demonstrated for the grain growth kinetics, the experimental...

  20. Computer-aided design of stripline ferrite junction circulators

    Science.gov (United States)

    Uzdy, Z.

    1980-01-01

    A general design procedure is presented for stripline Y-junction circulators employing solid dielectric between ground planes. The resonator design and impedance matching are derived in a form suitable for computer evaluation. The procedure is applicable to cases where either the circulator bandwidth or the ground plane spacing is specified. An experimental S-band switching circulator design illustrates the technique.

  1. Applying coupon-collecting theory to computer-aided assessments

    OpenAIRE

    2010-01-01

    Computer-based tests with randomly generated questions allow a large number of different tests to be generated. Given a fixed number of alternatives for each question, the number of tests that need to be generated before all possible questions have appeared is surprisingly low.

  2. Computer-Aided Instruction: College Algebra Students' Perceptions

    Science.gov (United States)

    Aichele, Douglas B.; Tree, D. Rae; Utley, Juliana; Wescoatt, Benjamin

    2012-01-01

    Technology permeates our daily lives; education has not been untouched. Liaw (2002) points out that "teachers, trainers, and instructional designers of computer-based or Web-based instruction would benefit by being more attentive to learners' perceptions toward Web-based environments." Reviewing the earlier research into student perceptions toward…

  3. A Computer-aided Learning Exercise in Spectrophotometry.

    Science.gov (United States)

    Pamula, Frederick

    1994-01-01

    Discusses the use of a computer simulation program in teaching the concepts of spectrophotometry. Introduces several parts of the program and program usage. Presents an assessment activity to evaluate students' mastery of material. Concludes with the advantages of this approach to the student and to the assessor. (ASK)

  4. Interactive Computer Aided Learning and Teaching of Analytical Mechanics

    Directory of Open Access Journals (Sweden)

    Aare Aan

    2011-10-01

    Full Text Available The aim of this paper is to introduce a new possibility for learning Analytical Mechanics via internet. This subject belongs to the field of engineering, the theoretical parts of lecture materials are available online in PDF format and have special links to switch on the interactive examples on the worksheets of the Computer Package Mathcad.

  5. The application of computer-aided designated titanium mesh in repairing skull defects

    Directory of Open Access Journals (Sweden)

    Lei ZHANG

    2015-01-01

    Full Text Available Objective To explore the clinical value of repairing skull defects with titanium alloy-mesh of computer-aided design.  Methods A retrospective analysis was done on clinical data of 86 cases with skull defects who underwent repairing using titanium mesh with two-dimensional or three-dimensional computer-aided design.  Results All the incisions achieved primary healing other than one case conducting reoperation due to exposed titanium mesh. Two cases got subcutaneous exudate, one obtained painful mastication and one experienced proliferation of scalp scar.  Conclusions With the computer-aided designated titanium mesh, relevant operation can resume the original state to maximum extent, lower surgical risk, decrease post-operational complications and then obtain satisfying clinical effect. DOI: 10.3969/j.issn.1672-6731.2015.01.015

  6. The Research of Computer Aided Farm Machinery Designing Method Based on Ergonomics

    Science.gov (United States)

    Gao, Xiyin; Li, Xinling; Song, Qiang; Zheng, Ying

    Along with agricultural economy development, the farm machinery product type Increases gradually, the ergonomics question is also getting more and more prominent. The widespread application of computer aided machinery design makes it possible that farm machinery design is intuitive, flexible and convenient. At present, because the developed computer aided ergonomics software has not suitable human body database, which is needed in view of farm machinery design in China, the farm machinery design have deviation in ergonomics analysis. This article puts forward that using the open database interface procedure in CATIA to establish human body database which aims at the farm machinery design, and reading the human body data to ergonomics module of CATIA can product practical application virtual body, using human posture analysis and human activity analysis module to analysis the ergonomics in farm machinery, thus computer aided farm machinery designing method based on engineering can be realized.

  7. Computer-aided modeling for efficient and innovative product-process engineering

    DEFF Research Database (Denmark)

    Heitzig, Martina

    Model-based computer aided product-process engineering has attained increased importance in a number of industries, including pharmaceuticals, petrochemicals, fine chemicals, polymers, biotechnology, food, energy and water. This trend is set to continue due to the substantial benefits computer...... in chemical and biochemical engineering have been solved to illustrate the application of the generic modelling methodology, the computeraided modelling framework and the developed software tool.......-aided methods provide. The key prerequisite of computer-aided productprocess engineering is however the availability of models of different types, forms and application modes. The development of the models required for the systems under investigation tends to be a challenging, time-consuming and therefore cost...

  8. Application of computer-aided multi-scale modelling framework – Aerosol case study

    DEFF Research Database (Denmark)

    Heitzig, Martina; Sin, Gürkan; Glarborg, Peter

    Model-based computer aided product-process engineering has attained increased importance in a number of industries, including pharmaceuticals, petrochemicals, fine chemicals, polymers, biotechnology, food, energy and water. This trend is set to continue due to the substantial benefits computer...... development part supports the modeller in model documentation, construction and analysis.Different models for properties, phenomena, unit operations, processes can be developed and analysed here or retrieved from model libraries.The model equations are introduced in a simple text format and are translated......-aided methods provide. The key prerequisite of computer-aided product-process engineering is however the availability of models of different types, forms and application modes. The development of the models required for the systems under investigation tends to be a challenging and time-consuming task involving...

  9. Research on the Procedure for Computer-Aided Pattern Design of Uygur's Flowered Hats

    Directory of Open Access Journals (Sweden)

    Shuxian Liu

    2013-05-01

    Full Text Available Xinjiang Uygur’s flowered hats is famous all over the world, it leads the world of headwear of variou nationalities within China by the variety of styles, the various ways of how to emroider pattern design and exquisite manufacture. It is unusual even in national costumes art of the world. The poupose of this study is to analyze Uygur's headwear, study the rules of Uygur's headwear pattern, analyze the characteristic of the basic pattern, research on the procedure for computer-aided pattern design of Uygur's flowered hat, explore the application of computer-aided design in traditional costume's pattern design and to realize application exploration of computer-aided design in designing of costume and dress adornment.

  10. Computer-aided modeling framework for efficient model development, analysis and identification

    DEFF Research Database (Denmark)

    Heitzig, Martina; Sin, Gürkan; Sales Cruz, Mauricio;

    2011-01-01

    branches; the first branch deals with single-scale model development while the second branch introduces features for multiscale model development to the methodology. In this paper, the emphasis is on single-scale model development and application part. The modeling framework and the supported stepwise......Model-based computer aided product-process engineering has attained increased importance in a number of industries, including pharmaceuticals, petrochemicals, fine chemicals, polymers, biotechnology, food, energy, and water. This trend is set to continue due to the substantial benefits computer......-aided methods introduce. The key prerequisite of computer-aided product-process engineering is however the availability of models of different types, forms, and application modes. The development of the models required for the systems under investigation tends to be a challenging and time-consuming task...

  11. Computer-aided detection of pulmonary embolism in computed tomographic pulmonary angiography (CTPA): Performance evaluation with independent data sets

    OpenAIRE

    Zhou, Chuan; Chan, Heang-Ping; Sahiner, Berkman; Hadjiiski, Lubomir M.; Chughtai, Aamer; Patel, Smita; Wei, Jun; Cascade, Philip N.; Kazerooni, Ella A.

    2009-01-01

    The authors are developing a computer-aided detection system for pulmonary emboli (PE) in computed tomographic pulmonary angiography (CTPA) scans. The pulmonary vessel tree is extracted using a 3D expectation-maximization segmentation method based on the analysis of eigenvalues of Hessian matrices at multiple scales. A parallel multiprescreening method is applied to the segmented vessels to identify volume of interests (VOIs) that contained suspicious PE. A linear discriminant analysis (LDA) ...

  12. Computer-Aided Engineering of Semiconductor Integrated Circuits

    Science.gov (United States)

    1979-07-01

    amount of empiricism needed to develop new structures. 2.2 SUMMARY OF PRINCIPAL ACCOMPLISHMENTS TO DATE The thermal oxidation work to be described here is...of excess silicon interstitials (Si) produced by the oxidation, then the temperature behavior of Qss may be rationalized . In the dry 02 case, for...slope vs temperature than does the dry 02 curve. This is in spite of the fact that more SiI are generated per unit time in the H20 case. One might

  13. Towards the automotive HMI of the future: Overview of the AIDE - Integrated project results

    NARCIS (Netherlands)

    Amditis, A.; Andreone, L.; Pagle, K.; Markkula, G.; Deregibus, E.; Romera Rue, M.; Bellotti, F.; Engelsberg, A.; Brouwer, R.; Peters, B.; Gloria, A. de

    2010-01-01

    The Adaptive Integrated Driver-vehicle interfacE (AIDE) is an integrated project funded by the European Commission in the Sixth Framework Programme. The project, which involves 31 partners from the European automotive industry and academia, deals with behavioral and technical issues related to autom

  14. Multicriteria aided design of integrated heating-cooling energy systems in buildings.

    Science.gov (United States)

    Mróz, Tomasz M

    2010-08-01

    This paper presents an analysis of the possible application of integrated heating-cooling systems in buildings. The general algorithm of integrated heating-cooling system design aid was formulated. The evaluation criteria of technically acceptable variants were defined. Fossil fuel energy consumption, carbon dioxide emission, investment, and total exploitation cost were identified as the most important factors describing the considered decision problem. The multicriteria decision aid method ELECTRE III was proposed as the decision tool for the choice of the most compromised variant. The proposed method was used for a case study calculation-the choice of an integrated heating-cooling system for an office building.

  15. Computer-aided breast MR image feature analysis for prediction of tumor response to chemotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Aghaei, Faranak; Tan, Maxine; Liu, Hong; Zheng, Bin, E-mail: Bin.Zheng-1@ou.edu [School of Electrical and Computer Engineering, University of Oklahoma, Norman, Oklahoma 73019 (United States); Hollingsworth, Alan B. [Mercy Women’s Center, Mercy Health Center, Oklahoma City, Oklahoma 73120 (United States); Qian, Wei [Department of Electrical and Computer Engineering, University of Texas, El Paso, Texas 79968 (United States)

    2015-11-15

    Purpose: To identify a new clinical marker based on quantitative kinetic image features analysis and assess its feasibility to predict tumor response to neoadjuvant chemotherapy. Methods: The authors assembled a dataset involving breast MR images acquired from 68 cancer patients before undergoing neoadjuvant chemotherapy. Among them, 25 patients had complete response (CR) and 43 had partial and nonresponse (NR) to chemotherapy based on the response evaluation criteria in solid tumors. The authors developed a computer-aided detection scheme to segment breast areas and tumors depicted on the breast MR images and computed a total of 39 kinetic image features from both tumor and background parenchymal enhancement regions. The authors then applied and tested two approaches to classify between CR and NR cases. The first one analyzed each individual feature and applied a simple feature fusion method that combines classification results from multiple features. The second approach tested an attribute selected classifier that integrates an artificial neural network (ANN) with a wrapper subset evaluator, which was optimized using a leave-one-case-out validation method. Results: In the pool of 39 features, 10 yielded relatively higher classification performance with the areas under receiver operating characteristic curves (AUCs) ranging from 0.61 to 0.78 to classify between CR and NR cases. Using a feature fusion method, the maximum AUC = 0.85 ± 0.05. Using the ANN-based classifier, AUC value significantly increased to 0.96 ± 0.03 (p < 0.01). Conclusions: This study demonstrated that quantitative analysis of kinetic image features computed from breast MR images acquired prechemotherapy has potential to generate a useful clinical marker in predicting tumor response to chemotherapy.

  16. Creating a strategic plan for configuration management using computer aided software engineering (CASE) tools

    Energy Technology Data Exchange (ETDEWEB)

    Smith, P.R.; Sarfaty, R.

    1993-05-01

    This paper provides guidance in the definition, documentation, measurement, enhancement of processes, and validation of a strategic plan for configuration management (CM). The approach and methodology used in establishing a strategic plan is the same for any enterprise, including the Department of Energy (DOE), commercial nuclear plants, the Department of Defense (DOD), or large industrial complexes. The principles and techniques presented are used world wide by some of the largest corporations. The authors used industry knowledge and the areas of their current employment to illustrate and provide examples. Developing a strategic configuration and information management plan for DOE Idaho Field Office (DOE-ID) facilities is discussed in this paper. A good knowledge of CM principles is the key to successful strategic planning. This paper will describe and define CM elements, and discuss how CM integrates the facility`s physical configuration, design basis, and documentation. The strategic plan does not need the support of a computer aided software engineering (CASE) tool. However, the use of the CASE tool provides a methodology for consistency in approach, graphics, and database capability combined to form an encyclopedia and a method of presentation that is easily understood and aids the process of reengineering. CASE tools have much more capability than those stated above. Some examples are supporting a joint application development group (JAD) to prepare a software functional specification document and, if necessary, provide the capability to automatically generate software application code. This paper briefly discusses characteristics and capabilities of two CASE tools that use different methodologies to generate similar deliverables.

  17. Computer-aided hepatic tumour ablation requirements and preliminary results

    CERN Document Server

    Voirin, D; Amavizca, M; Letoublon, C; Troccaz, J; Voirin, David; Payan, Yohan; Amavizca, Miriam; Letoublon, Christian; Troccaz, Jocelyne

    2002-01-01

    Surgical resection of hepatic tumours is not always possible, since it depends on different factors, among which their location inside the liver functional segments. Alternative techniques consist in local use of chemical or physical agents to destroy the tumour. Radio frequency and cryosurgical ablations are examples of such alternative techniques that may be performed percutaneously. This requires a precise localisation of the tumour placement during ablation. Computer-assisted surgery tools may be used in conjunction with these new ablation techniques to improve the therapeutic efficiency, whilst they benefit from minimal invasiveness. This paper introduces the principles of a system for computer-assisted hepatic tumour ablation and describes preliminary experiments focusing on data registration evaluation. To keep close to conventional protocols, we consider registration of pre-operative CT or MRI data to intra-operative echographic data.

  18. Bioassay Phantoms Using Medical Images and Computer Aided Manufacturing

    Energy Technology Data Exchange (ETDEWEB)

    Dr. X. Geroge Xu

    2011-01-28

    A radiation bioassay program relies on a set of standard human phantoms to calibrate and assess radioactivity levels inside a human body for radiation protection and nuclear medicine imaging purposes. However, the methodologies in the development and application of anthropomorphic phantoms, both physical and computational, had mostly remained the same for the past 40 years. We herein propose a 3-year research project to develop medical image-based physical and computational phantoms specifically for radiation bioassay applications involving internally deposited radionuclides. The broad, long-term objective of this research was to set the foundation for a systematic paradigm shift away from the anatomically crude phantoms in existence today to realistic and ultimately individual-specific bioassay methodologies. This long-term objective is expected to impact all areas of radiation bioassay involving nuclear power plants, U.S. DOE laboratories, and nuclear medicine clinics.

  19. Computer aided discovery of families of valid inequalities

    DEFF Research Database (Denmark)

    Røpke, Stefan; Cordeau, Jean-Francois; Laporte, Gilbert

    We present a computer program that helps the user discovering new families of valid inequalities for any integer program. It does so by finding simple valid inequalities that are violated by a fractional solution supplied by the user. It is up to the user to generalize these inequalities further........ We present new families of inequalities for the capacitated vehicle routing problem and the traveling salesman problem with pickup and deliveries found using the program....

  20. Computer-Aided Process Model For Carbon/Phenolic Materials

    Science.gov (United States)

    Letson, Mischell A.; Bunker, Robert C.

    1996-01-01

    Computer program implements thermochemical model of processing of carbon-fiber/phenolic-matrix composite materials into molded parts of various sizes and shapes. Directed toward improving fabrication of rocket-engine-nozzle parts, also used to optimize fabrication of other structural components, and material-property parameters changed to apply to other materials. Reduces costs by reducing amount of laboratory trial and error needed to optimize curing processes and to predict properties of cured parts.

  1. A digital patient for computer-aided prosthesis design

    OpenAIRE

    Colombo, Giorgio; Facoetti, Giancarlo; Rizzi, Caterina

    2013-01-01

    This article concerns the design of lower limb prosthesis, both below and above knee. It describes a new computer-based design framework and a digital model of the patient around which the prosthesis is designed and tested in a completely virtual environment. The virtual model of the patient is the backbone of the whole system, and it is based on a biomechanical general-purpose model customized with the patient's characteristics (e.g. anthropometric measures). The software platform adopts com...

  2. Computer-aided stream pollution control and management. Part I

    Energy Technology Data Exchange (ETDEWEB)

    Wang, M.H. (New York State Dept. of Environmental Conservation, White Plains); Wang, L.K.; Kao, J.F.; Wen, C.G.; Vielkind, D.

    1979-09-01

    A comparison between the Streeter-Phelps method and the Churchill and Buckingham method is made. Principles of multiple linear correlation are described. Normal equations, a standard error equation and a correlation coefficient equation are derived. Two mathematical models involving the multiple linear correlation of four critical parameters (dissolved oxygen, biochemical oxygen demand, water temperature, and river flow) near a point source of pollution are derived with a FORTRAN computer program.

  3. Computer-aided synthesis and design of plant utility systems

    Energy Technology Data Exchange (ETDEWEB)

    Petroulas, T.; Reklaitis, G.V.

    1984-01-01

    A design synthesis procedure is developed for preliminary design of utility systems. Given known steam sources (waste heat and auxiliary boilers) and sinks (heating, process injection, and driver horsepower needs), the algorithm determines the optimal header pressure levels, the distribution of steam turbines in the network, and the steam flows between all devices so as to maximize the real work recovered from the sources. Any number of pressure levels can be accommodated at only modest increase in computational effort.

  4. Energy-aware memory management for embedded multimedia systems a computer-aided design approach

    CERN Document Server

    Balasa, Florin

    2011-01-01

    Energy-Aware Memory Management for Embedded Multimedia Systems: A Computer-Aided Design Approach presents recent computer-aided design (CAD) ideas that address memory management tasks, particularly the optimization of energy consumption in the memory subsystem. It explains how to efficiently implement CAD solutions, including theoretical methods and novel algorithms. The book covers various energy-aware design techniques, including data-dependence analysis techniques, memory size estimation methods, extensions of mapping approaches, and memory banking approaches. It shows how these techniques

  5. Computer-Aided Process and Tools for Mobile Software Acquisition

    Science.gov (United States)

    2013-04-01

    benefits , the ARP will endeavor to stimulate this dialogue through various means throughout the year as we interact with our researchers and DoD...Program Executive Officer, SHIPS  Commander, Naval Sea Systems Command  Program Executive Officer, Integrated Warfare Systems  Army Contracting...Lesspainful Device Lab, n.d.). The customers use the programming language Cucumber to write an English description of the test they would like to

  6. CAMRAD - COMPUTER AIDED MATERIAL REVIEW AUTOMATED DISPOSITION SYSTEM

    Science.gov (United States)

    Hanna, T. L.

    1994-01-01

    The basic function of a manufacturer's production support engineering unit is to identify, document, and dispose of hardware that does not conform to drawing requirements. CAMRAD, a program designed for rapid input and retrieval of all data used in engineering-to-manufacturing support operations, aids the engineer by automating the material review disposition process. Before CAMRAD, material review record searches were manual. The time spent searching through old documents precluded the timely disposition of new material reviews. CAMRAD facilitates the research of material review histories and provides for the efficient processing of material review documents. Three SmartWare project files control the operation of CAMRAD. The project file CAMRAD initializes variables for the other project files and specifies the pathing of the CAMRAD program, database files, and document files. The project file DATARAD controls all data management functions. The database consists of individual files containing all records of specific hardware discrepancies for a given part number. There are four basic avenues for records searches: part serial number, feature, Material Review (MR) number, and non-conformance. WORDRAD is the project file which controls the management of document files created when processing a material review disposition. Given a material review report identifying a defective hardware item, the production support engineer can use CAMRAD to quickly search the database for any history of the same problem, find out how well the problem has been documented, and create appropriate documentation for this latest occurrence. CAMRAD is written in the Smart Programming Language and is designed to run on IBM PC compatibles with the SmartWare v. 3.1 software package available from Informix Software. CAMRAD was developed in 1987. SmartWare is a registered trademark of Informix Software, Inc. IBM PC is a registered trademark of International Business Machines Corporation.

  7. Computer Aided Ballistic Orbit Classification Around Small Bodies

    Science.gov (United States)

    Villac, Benjamin F.; Anderson, Rodney L.; Pini, Alex J.

    2016-09-01

    Orbital dynamics around small bodies are as varied as the shapes and dynamical states of these bodies. While various classes of orbits have been analyzed in detail, the global overview of relevant ballistic orbits at particular bodies is not easily computed or organized. Yet, correctly categorizing these orbits will ease their future use in the overall trajectory design process. This paper overviews methods that have been used to organize orbits, focusing on periodic orbits in particular, and introduces new methods based on clustering approaches.

  8. Computer-aided analysis of nonlinear problems in transport phenomena

    Science.gov (United States)

    Brown, R. A.; Scriven, L. E.; Silliman, W. J.

    1980-01-01

    The paper describes algorithms for equilibrium and steady-state problems with coefficients in the expansions derived by the Galerkin weighted residual method and calculated from the resulting sets of nonlinear algebraic equations by the Newton-Raphson method. Initial approximations are obtained from nearby solutions by continuation techniques as parameters are varied. The Newton-Raphson technique is preferred because the Jacobian of the solution is useful for continuation, for analyzing the stability of solutions, for detecting bifurcation of solution families, and for computing asymptotic estimates of the effects on any solution of small changes in parameters, boundary conditions, and boundary shape.

  9. Computer Aided Flowsheet Design using Group Contribution Methods

    DEFF Research Database (Denmark)

    Bommareddy, Susilpa; Eden, Mario R.; Gani, Rafiqul

    In this paper, a systematic group contribution based framework is presented for synthesis of process flowsheets from a given set of input and output specifications. Analogous to the group contribution methods developed for molecular design, the framework employs process groups to represent...... information of each flowsheet to minimize the computational load and information storage. The design variables for the selected flowsheet(s) are identified through a reverse simulation approach and are used as initial estimates for rigorous simulation to verify the feasibility and performance of the design....

  10. COMPUTER AIDED DISTANCE HOUSE AUTOMATION BY TELEPHONE LINE ACCESS

    Directory of Open Access Journals (Sweden)

    İbrahim ÇAYIROĞLU

    2007-03-01

    Full Text Available In this study, control and automation of house instruments have been practiced by using a distance telephone line and a modem. A user can use the buttons of a telephone in distance and he can control the instruments at home. In order to data acquisition from a modem, TAPIEx ActiveX Control 2.6 software has been used. An interface to fulfill the operation provided from the software and controlling the ports has been written. To drive relays from computer output, a relay circuit has been designed. The all instruments at home have been controlled by the relay controlled.

  11. Computer-Aided Design of Photocured Polymer Networks

    Science.gov (United States)

    Sarkar, Swarnavo; Lin-Gibson, Sheng; Chiang, Martin

    Light-initiated free radical polymerization is widely used for manufacturing biomaterials, scaffolds for micomolding, and is being developed as a method for fast 3D fabrication. This process has a large set of control parameters in the composition of the photocurable matrix and the photocuring conditions. But a quantitative map between the choice of parameters and the properties of the resultant polymer is currently unavailable. We present a computational approach to simulate the growth of a polymer network using the stochastic differential equations of reactions and diffusion for a photocuring system. This method allows us to sample trajectories of a growing polymer network in silico. Thus, we provide a computational alternative to synthesize and probe a polymer network for properties like the degree of conversion, structure factor, density of states, and viscosity. We present simulation results that agree with the universal features observed in photopolymerization. Our proposed method enables a thorough and systematic search over the entire parameter space to discover interesting combinations for synthesis.

  12. Computer-Aided Design of RNA Origami Structures.

    Science.gov (United States)

    Sparvath, Steffen L; Geary, Cody W; Andersen, Ebbe S

    2017-01-01

    RNA nanostructures can be used as scaffolds to organize, combine, and control molecular functionalities, with great potential for applications in nanomedicine and synthetic biology. The single-stranded RNA origami method allows RNA nanostructures to be folded as they are transcribed by the RNA polymerase. RNA origami structures provide a stable framework that can be decorated with functional RNA elements such as riboswitches, ribozymes, interaction sites, and aptamers for binding small molecules or protein targets. The rich library of RNA structural and functional elements combined with the possibility to attach proteins through aptamer-based binding creates virtually limitless possibilities for constructing advanced RNA-based nanodevices.In this chapter we provide a detailed protocol for the single-stranded RNA origami design method using a simple 2-helix tall structure as an example. The first step involves 3D modeling of a double-crossover between two RNA double helices, followed by decoration with tertiary motifs. The second step deals with the construction of a 2D blueprint describing the secondary structure and sequence constraints that serves as the input for computer programs. In the third step, computer programs are used to design RNA sequences that are compatible with the structure, and the resulting outputs are evaluated and converted into DNA sequences to order.

  13. Integrating structure-based and ligand-based approaches for computational drug design.

    Science.gov (United States)

    Wilson, Gregory L; Lill, Markus A

    2011-04-01

    Methods utilized in computer-aided drug design can be classified into two major categories: structure based and ligand based, using information on the structure of the protein or on the biological and physicochemical properties of bound ligands, respectively. In recent years there has been a trend towards integrating these two methods in order to enhance the reliability and efficiency of computer-aided drug-design approaches by combining information from both the ligand and the protein. This trend resulted in a variety of methods that include: pseudoreceptor methods, pharmacophore methods, fingerprint methods and approaches integrating docking with similarity-based methods. In this article, we will describe the concepts behind each method and selected applications.

  14. Computer-aided drug discovery research at a global contract research organization

    Science.gov (United States)

    Kitchen, Douglas B.

    2017-03-01

    Computer-aided drug discovery started at Albany Molecular Research, Inc in 1997. Over nearly 20 years the role of cheminformatics and computational chemistry has grown throughout the pharmaceutical industry and at AMRI. This paper will describe the infrastructure and roles of CADD throughout drug discovery and some of the lessons learned regarding the success of several methods. Various contributions provided by computational chemistry and cheminformatics in chemical library design, hit triage, hit-to-lead and lead optimization are discussed. Some frequently used computational chemistry techniques are described. The ways in which they may contribute to discovery projects are presented based on a few examples from recent publications.

  15. A Simple and Resource-efficient Setup for the Computer-aided Drug Design Laboratory.

    Science.gov (United States)

    Moretti, Loris; Sartori, Luca

    2016-10-01

    Undertaking modelling investigations for Computer-Aided Drug Design (CADD) requires a proper environment. In principle, this could be done on a single computer, but the reality of a drug discovery program requires robustness and high-throughput computing (HTC) to efficiently support the research. Therefore, a more capable alternative is needed but its implementation has no widespread solution. Here, the realization of such a computing facility is discussed, from general layout to technical details all aspects are covered. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Computer-aided drug discovery research at a global contract research organization

    Science.gov (United States)

    Kitchen, Douglas B.

    2016-11-01

    Computer-aided drug discovery started at Albany Molecular Research, Inc in 1997. Over nearly 20 years the role of cheminformatics and computational chemistry has grown throughout the pharmaceutical industry and at AMRI. This paper will describe the infrastructure and roles of CADD throughout drug discovery and some of the lessons learned regarding the success of several methods. Various contributions provided by computational chemistry and cheminformatics in chemical library design, hit triage, hit-to-lead and lead optimization are discussed. Some frequently used computational chemistry techniques are described. The ways in which they may contribute to discovery projects are presented based on a few examples from recent publications.

  17. Sensor fusion control system for computer integrated manufacturing

    CSIR Research Space (South Africa)

    Kumile, CM

    2007-08-01

    Full Text Available of products in unpredictable quantities. Computer Integrated Manufacturing (CIM) systems plays an important role towards integrating such flexible systems. This paper presents a methodology of increasing flexibility and reusability of a generic CIM cell...

  18. Computer-aided detection (CAD) of breast masses in mammography: combined detection and ensemble classification

    Science.gov (United States)

    Choi, Jae Young; Kim, Dae Hoe; Plataniotis, Konstantinos N.; Ro, Yong Man

    2014-07-01

    We propose a novel computer-aided detection (CAD) framework of breast masses in mammography. To increase detection sensitivity for various types of mammographic masses, we propose the combined use of different detection algorithms. In particular, we develop a region-of-interest combination mechanism that integrates detection information gained from unsupervised and supervised detection algorithms. Also, to significantly reduce the number of false-positive (FP) detections, the new ensemble classification algorithm is developed. Extensive experiments have been conducted on a benchmark mammogram database. Results show that our combined detection approach can considerably improve the detection sensitivity with a small loss of FP rate, compared to representative detection algorithms previously developed for mammographic CAD systems. The proposed ensemble classification solution also has a dramatic impact on the reduction of FP detections; as much as 70% (from 15 to 4.5 per image) at only cost of 4.6% sensitivity loss (from 90.0% to 85.4%). Moreover, our proposed CAD method performs as well or better (70.7% and 80.0% per 1.5 and 3.5 FPs per image respectively) than the results of mammography CAD algorithms previously reported in the literature.

  19. Computer-aided diagnosis and lipidomics analysis to detect and treat breast cancer

    Science.gov (United States)

    Meyer-Bäse, Anke; Retter, Felix; Steinbrücker, Frank; Görke, Robert; Burgeth, Bernhard; Schlossbauer, Thomas

    2010-04-01

    Multi-modality diagnosis techniques are more and more replacing traditional medical imaging for breast cancer detection. Newly emerging advances in both intelligent cancer detection systems and lipidomics technologies offer an excellent opportunity to detect tumors and to understand regulation at the molecular level in many diseases such as cancer. In this paper, we present a detailed computer-aided diagnosis (CAD) systems combining motion artefact reduction and automated feature extraction and classification, and a novel data mining approach for visualization of gene therapy leading to apoptosis in U87 MG glioblastoma cells, a secondary tumor of breast cancer. The achieved results show that the CAD system represents a robust and integrative tool for reliable small contrast enhancing lesions. Graph-clustering methods are introduced as powerful correlation networks which enable a simultaneous exploration and visualization of co-regulation in glioblastoma data. These new paradigms are providing unique "fingerprints" by revealing how the intricate interactions at the lipidome level can be employed to induce apoptosis (cell death) and are thus opening a new window to biomedical frontiers.

  20. Computer-Aided Diagnosis Of Leukemic Blood Cells

    Science.gov (United States)

    Gunter, U.; Harms, H.; Haucke, M.; Aus, H. M.; ter Meulen, V.

    1982-11-01

    In a first clinical test, computer programs are being used to diagnose leukemias. The data collected include blood samples from patients suffering from acute myelomonocytic-, acute monocytic- and acute promyelocytic, myeloblastic, prolymphocytic, chronic lymphocytic leukemias and leukemic transformed immunocytoma. The proper differentiation of the leukemic cells is essential because the therapy depends on the type of leukemia. The algorithms analyse the fine chromatin texture and distribution in the nuclei as well as size and shape parameters from the cells and nuclei. Cells with similar nuclei from different leukemias can be distinguished from each other by analyzing the cell cytoplasm images. Recognition of these subtle differences in the cells require an image sampling rate of 15-30 pixel/micron. The results for the entire data set correlate directly to established hematological parameters and support the previously published initial training set .

  1. Computer-aided selection of materials for cryogenic turbopump bearings

    Science.gov (United States)

    Maurer, R. E.; Pallini, R. A.

    1985-01-01

    The life requirement for the angular contact ball bearings in the Space Shuttle Main Engine (SSME) high-pressure-oxygen turbopump (HPOTP) is 7.5 hours. In actual operation, significantly shorter service life has been experienced. The objective of this current program is to identify bearing materials and/or materials processing techniques offering significant potential for extending HPOTP bearing performance life. A thermomechanical analysis of the HPOTP shaft/bearing system was performed with the SHABERTH (SHaft-BEaring-THermal) computer program. Bearing fatigue life, ball-race contact stress, heat generation rate, bulk ring temperatures, and circumferential stress in the inner rings were quantified as functions of radial load, thrust load, and ball-race contact friction. The analysis results were used to formulate criteria that are being used for the selection of special materials for future turbopump bearings.

  2. Computer-aided design of broad band reflection type amplifiers

    DEFF Research Database (Denmark)

    Hammershaimb, Edgar; Jeppesen, Palle; Schjær-Jacobsen, Hans

    1974-01-01

    Microwave negative resistance reflection type amplifiers using stable transferred electron devices (TED's) are optimized by numerical optimization techniques programmed for an interactive graphic datascreen. The small signal impedance of packaged TED's is measured on an automatic network analyzer....... At the same time the impedance of unpackaged devices are obtained by on-line correction for the package parasitics. The microwave circuit chosen is a multiple slug coaxial cavity, that is modelled by sections of lossy transmission lines including step susceptances. The measured small signal impedance...... of the packaged TED's and the cavity model are used in a direct optimization procedure, in which the calculated minimum gain in the prescribed frequency range is progressively maximized by adjusting the lengths, characteristic impedances and positions of the slugs. The computed results are displayed...

  3. Computer aided power flow software engineering and code generation

    Energy Technology Data Exchange (ETDEWEB)

    Bacher, R. [Swiss Federal Inst. of Tech., Zuerich (Switzerland)

    1996-02-01

    In this paper a software engineering concept is described which permits the automatic solution of a non-linear set of network equations. The power flow equation set can be seen as a defined subset of a network equation set. The automated solution process is the numerical Newton-Raphson solution process of the power flow equations where the key code parts are the numeric mismatch and the numeric Jacobian term computation. It is shown that both the Jacobian and the mismatch term source code can be automatically generated in a conventional language such as Fortran or C. Thereby one starts from a high level, symbolic language with automatic differentiation and code generation facilities. As a result of this software engineering process an efficient, very high quality newton-Raphson solution code is generated which allows easier implementation of network equation model enhancements and easier code maintenance as compared to hand-coded Fortran or C code.

  4. Computer aided power flow software engineering and code generation

    Energy Technology Data Exchange (ETDEWEB)

    Bacher, R. [Swiss Federal Inst. of Tech., Zuerich (Switzerland)

    1995-12-31

    In this paper a software engineering concept is described which permits the automatic solution of a non-linear set of network equations. The power flow equation set can be seen as a defined subset of a network equation set. The automated solution process is the numerical Newton-Raphson solution process of the power flow equations where the key code parts are the numeric mismatch and the numeric Jacobian term computation. It is shown that both the Jacobian and the mismatch term source code can be automatically generated in a conventional language such as Fortran or C. Thereby one starts from a high level, symbolic language with automatic differentiation and code generation facilities. As a result of this software engineering process an efficient, very high quality Newton-Raphson solution code is generated which allows easier implementation of network equation model enhancements and easier code maintenance as compared to hand-coded Fortran or C code.

  5. Integrated Computational System for Electrochemical Device Design and Simulation Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Illinois Rocstar LLC proposes to develop and demonstrate the use of an integrated computational environment and infrastructure for electrochemical device design and...

  6. Application of computer-aided multi-scale modelling framework – Aerosol case study

    DEFF Research Database (Denmark)

    Heitzig, Martina; Sin, Gürkan; Glarborg, Peter

    -aided methods provide. The key prerequisite of computer-aided product-process engineering is however the availability of models of different types, forms and application modes. The development of the models required for the systems under investigation tends to be a challenging and time-consuming task involving...... numerous steps, expert skills and different modelling tools. This motivates the development of a computer-aided modelling framework that supports the user during model development, documentation, analysis, identification, application and re-use with the goal to increase the efficiency of the modelling...... generation, optimal equation ordering, eigenvalue analysis. Once the models have been constructed and analysed the modelling framework incorporates 3 application work-flows for: identification, simulation and design. For these application work-flows different solvers that can solve a large range of different...

  7. A Robust and Fast System for CTC Computer-Aided Detection of Colorectal Lesions

    OpenAIRE

    2010-01-01

    We present a complete, end-to-end computer-aided detection (CAD) system for identifying lesions in the colon, imaged with computed tomography (CT). This system includes facilities for colon segmentation, candidate generation, feature analysis, and classification. The algorithms have been designed to offer robust performance to variation in image data and patient preparation. By utilizing efficient 2D and 3D processing, software optimizations, multi-threading, feature selection, and an optimiz...

  8. Review of research and development of computer-aided Kansei Engineering

    Institute of Scientific and Technical Information of China (English)

    Li LIN; Chengqi XUE

    2009-01-01

    Kansei Engineering is an important research approach and has become the hotspot of research in design fields. The concept of Kansei Engineering is introduced based on the investigation of related literatures. The working process and the key technology of computer-aided Kansei Engineering systems are discussed. Finally, the development trend of Kansei Engineering is outlined according to the development of computer and networking technology.

  9. Design and Implementation of 3 Axis CNC Router for Computer Aided Manufacturing Courses

    OpenAIRE

    Aktan Mehmet Emin; Akkuş Nihat; Yılmaz Abdurrahman; Akdoğan Erhan

    2016-01-01

    In this paper, it is intended to make the mechanical design of 3 axis Computer Numerical Control (CNC) router with linear joints, production of electronic control interface cards and drivers and manufacturing of CNC router system which is a combination of mechanics and electronics. At the same time, interface program has been prepared to control router via USB. The router was developed for educational purpose. In some vocational schools and universities, Computer Aided Manufacturing (CAM) cou...

  10. COMPUTER-AIDED DRUG DISCOVERY AND DEVELOPMENT (CADDD): in silico-chemico-biological approach

    OpenAIRE

    Kapetanovic, I.M.

    2006-01-01

    It is generally recognized that drug discovery and development are very time and resources consuming processes. There is an ever growing effort to apply computational power to the combined chemical and biological space in order to streamline drug discovery, design, development and optimization. In biomedical arena, computer-aided or in silico design is being utilized to expedite and facilitate hit identification, hit-to-lead selection, optimize the absorption, distribution, metabolism, excret...

  11. On Combining Multiple-Instance Learning and Active Learning for Computer-Aided Detection of Tuberculosis

    NARCIS (Netherlands)

    Melendez Rodriguez, J.C.; Ginneken, B. van; Maduskar, P.; Philipsen, R.H.H.M.; Ayles, H.; Sanchez, C.I.

    2016-01-01

    The major advantage of multiple-instance learning (MIL) applied to a computer-aided detection (CAD) system is that it allows optimizing the latter with case-level labels instead of accurate lesion outlines as traditionally required for a supervised approach. As shown in previous work, a MIL-based

  12. The computer-aided design of a servo system as a multiple-criteria decision problem

    NARCIS (Netherlands)

    Udink ten Cate, A.J.

    1986-01-01

    This paper treats the selection of controller gains of a servo system as a multiple-criteria decision problem. In contrast to the usual optimization-based approaches to computer-aided design, inequality constraints are included in the problem as unconstrained objectives. This considerably simplifies

  13. Application of computer-aided multi-scale modelling framework - Aerosol case study

    DEFF Research Database (Denmark)

    Heitzig, Martina; Gregson, Christopher; Sin, Gürkan;

    2011-01-01

    A computer-aided modelling tool for efficient multi-scale modelling has been developed and is applied to solve a multi-scale modelling problem related to design and evaluation of fragrance aerosol products. The developed modelling scenario spans three length scales and describes how droplets...

  14. SMART USE OF COMPUTER-AIDED SPERM ANALYSIS (CASA) TO CHARACTERIZE SPERM MOTION

    Science.gov (United States)

    Computer-aided sperm analysis (CASA) has evolved over the past fifteen years to provide an objective, practical means of measuring and characterizing the velocity and parttern of sperm motion. CASA instruments use video frame-grabber boards to capture multiple images of spermato...

  15. Lecturers' Perspectives on the Use of a Mathematics-Based Computer-Aided Assessment System

    Science.gov (United States)

    Broughton, Stephen J.; Robinson, Carol L.; Hernandez-Martinez, Paul

    2013-01-01

    Computer-aided assessment (CAA) has been used at a university with one of the largest mathematics and engineering undergraduate cohorts in the UK for more than ten years. Lecturers teaching mathematics to first year students were asked about their current use of CAA in a questionnaire and in interviews. This article presents the issues that these…

  16. Persons with Alzheimer's Disease Make Phone Calls Independently Using a Computer-Aided Telephone System

    Science.gov (United States)

    Perilli, Viviana; Lancioni, Giulio E.; Singh, Nirbhay N.; O'Reilly, Mark F.; Sigafoos, Jeff; Cassano, Germana; Cordiano, Noemi; Pinto, Katia; Minervini, Mauro G.; Oliva, Doretta

    2012-01-01

    This study assessed whether four patients with a diagnosis of Alzheimer's disease could make independent phone calls via a computer-aided telephone system. The study was carried out according to a non-concurrent multiple baseline design across participants. All participants started with baseline during which the telephone system was not available,…

  17. Automatic computer-aided detection of prostate cancer based on multiparametric magnetic resonance image analysis.

    NARCIS (Netherlands)

    Vos, P.C.; Barentsz, J.O.; Karssemeijer, N.; Huisman, H.J.

    2012-01-01

    In this paper, a fully automatic computer-aided detection (CAD) method is proposed for the detection of prostate cancer. The CAD method consists of multiple sequential steps in order to detect locations that are suspicious for prostate cancer. In the initial stage, a voxel classification is performe

  18. Computer-aided detection in breast MRI : a systematic review and meta-analysis

    NARCIS (Netherlands)

    Dorrius, Monique D.; Jansen-van der Weide, Marijke C.; van Ooijen, Peter M. A.; Pijnappel, Ruud M.; Oudkerk, Matthijs

    To evaluate the additional value of computer-aided detection (CAD) in breast MRI by assessing radiologists' accuracy in discriminating benign from malignant breast lesions. A literature search was performed with inclusion of relevant studies using a commercially available CAD system with automatic

  19. Standalone computer-aided detection compared to radiologists' performance for the detection of mammographic masses

    NARCIS (Netherlands)

    Hupse, R.; Samulski, M.; Lobbes, M.; Heeten, A. den; Imhof-Tas, M.W.; Beijerinck, D.; Pijnappel, R.; Hitge-Boetes, C.; Karssemeijer, N.

    2013-01-01

    OBJECTIVES: We developed a computer-aided detection (CAD) system aimed at decision support for detection of malignant masses and architectural distortions in mammograms. The effect of this system on radiologists' performance depends strongly on its standalone performance. The purpose of this study

  20. Gathering Empirical Evidence Concerning Links between Computer Aided Design (CAD) and Creativity

    Science.gov (United States)

    Musta'amal, Aede Hatib; Norman, Eddie; Hodgson, Tony

    2009-01-01

    Discussion is often reported concerning potential links between computer-aided designing and creativity, but there is a lack of systematic enquiry to gather empirical evidence concerning such links. This paper reports an indication of findings from other research studies carried out in contexts beyond general education that have sought evidence…

  1. Shape sensing for computer aided below-knee prosthetic socket design.

    Science.gov (United States)

    Fernie, G R; Griggs, G; Bartlett, S; Lunau, K

    1985-04-01

    Shape sensing is useful in the computer aided prosthetic fitting process for two purposes. 1. To input characteristic prosthetic shapes that have been developed over the years through the experience of prosthetists. 2. To provide an accurate and rapid measurement of the anatomical shape of the stump. This paper describes two instruments which have been built to meet these objectives.

  2. Technology and Jobs: Computer-Aided Design. Numerical-Control Machine-Tool Operators. Office Automation.

    Science.gov (United States)

    Stanton, Michael; And Others

    1985-01-01

    Three reports on the effects of high technology on the nature of work include (1) Stanton on applications and implications of computer-aided design for engineers, drafters, and architects; (2) Nardone on the outlook and training of numerical-control machine tool operators; and (3) Austin and Drake on the future of clerical occupations in automated…

  3. MULTI-AGENT COMPUTER AIDED ASSEMBLY PROCESS PLANNING SYSTEM FOR SHIP HULL

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    A multi-agent computer aided assembly process planning system (MCAAPP) for ship hull is presented. The system includes system framework, global facilitator, the macro agent structure, agent communication language, agent-oriented programming language, knowledge representation and reasoning strategy. The system can produce the technological file and technological quota, which can satisfy the production needs of factory.

  4. Effect of Computer-Aided Instruction on Attitude and Achievement of Fifth Grade Math Students

    Science.gov (United States)

    Shoemaker, Traci L.

    2013-01-01

    The purpose of this quasi-experimental non-equivalent control group study was to test theories of constructivism and motivation, along with research-based teaching practices of differentiating instruction and instructing within a child's Zone of Proximal Development, in measuring the effect of computer-aided instruction on fifth grade students'…

  5. Effect of Computer-Aided Perspective Drawings on Spatial Orientation and Perspective Drawing Achievement

    Science.gov (United States)

    Kurtulus, Aytac

    2011-01-01

    The aim of this study is to investigate the effect of computer-aided Perspective Drawings on eighth grade primary school students' achievement in Spatial Orientation and Perspective Drawing. The study made use of pre-test post-test control group experimental design. The study was conducted with thirty 8th grade students attending a primary school…

  6. The Computer-Aided Analytic Process Model. Operations Handbook for the Analytic Process Model Demonstration Package

    Science.gov (United States)

    1986-01-01

    Research Note 86-06 THE COMPUTER-AIDED ANALYTIC PROCESS MODEL : OPERATIONS HANDBOOK FOR THE ANALYTIC PROCESS MODEL DE ONSTRATION PACKAGE Ronald G...ic Process Model ; Operations Handbook; Tutorial; Apple; Systems Taxonomy Mod--l; Training System; Bradl1ey infantry Fighting * Vehicle; BIFV...8217. . . . . . . .. . . . . . . . . . . . . . . . * - ~ . - - * m- .. . . . . . . item 20. Abstract -continued companion volume-- "The Analytic Process Model for

  7. Computer-aided decision support systems for endoscopy in the gastrointestinal tract: a review.

    Science.gov (United States)

    Liedlgruber, Michael; Uhl, Andreas

    2011-01-01

    Today, medical endoscopy is a widely used procedure to inspect the inner cavities of the human body. The advent of endoscopic imaging techniques-allowing the acquisition of images or videos-created the possibility for the development of the whole new branch of computer-aided decision support systems. Such systems aim at helping physicians to identify possibly malignant abnormalities more accurately. At the beginning of this paper, we give a brief introduction to the history of endoscopy, followed by introducing the main types of endoscopes which emerged so far (flexible endoscope, wireless capsule endoscope, and confocal laser endomicroscope). We then give a brief introduction to computer-aided decision support systems specifically targeted at endoscopy in the gastrointestinal tract. Then we present general facts and figures concerning computer-aided decision support systems and summarize work specifically targeted at computer-aided decision support in the gastrointestinal tract. This summary is followed by a discussion of some common issues concerning the approaches reviewed and suggestions of possible ways to resolve them.

  8. Data Management Standards in Computer-aided Acquisition and Logistic Support (CALS)

    Science.gov (United States)

    Jefferson, David K.

    1990-01-01

    Viewgraphs and discussion on data management standards in computer-aided acquisition and logistic support (CALS) are presented. CALS is intended to reduce cost, increase quality, and improve timeliness of weapon system acquisition and support by greatly improving the flow of technical information. The phase 2 standards, industrial environment, are discussed. The information resource dictionary system (IRDS) is described.

  9. Increasing computer-aided detection specificity by projection features for CT colonography

    OpenAIRE

    Zhu, Hongbin; Liang, Zhengrong; Pickhardt, Perry J.; Barish, Matthew A.; You, Jiangsheng; Fan, Yi; Lu, Hongbing; Posniak, Erica J.; Richards, Robert J.; Cohen, Harris L.

    2010-01-01

    Purpose: A large number of false positives (FPs) generated by computer-aided detection (CAD) schemes is likely to distract radiologists’ attention and decrease their interpretation efficiency. This study aims to develop projection-based features which characterize true and false positives to increase the specificity while maintaining high sensitivity in detecting colonic polyps.

  10. SMART USE OF COMPUTER-AIDED SPERM ANALYSIS (CASA) TO CHARACTERIZE SPERM MOTION

    Science.gov (United States)

    Computer-aided sperm analysis (CASA) has evolved over the past fifteen years to provide an objective, practical means of measuring and characterizing the velocity and parttern of sperm motion. CASA instruments use video frame-grabber boards to capture multiple images of spermato...

  11. Experiments Using Cell Phones in Physics Classroom Education: The Computer-Aided "g" Determination

    Science.gov (United States)

    Vogt, Patrik; Kuhn, Jochen; Muller, Sebastian

    2011-01-01

    This paper continues the collection of experiments that describe the use of cell phones as experimental tools in physics classroom education. We describe a computer-aided determination of the free-fall acceleration "g" using the acoustical Doppler effect. The Doppler shift is a function of the speed of the source. Since a free-falling objects…

  12. Comparative evaluation of support vector machine classification for computer aided detection of breast masses in mammography

    NARCIS (Netherlands)

    Lesniak, J.M.; Hupse, R.; Blanc, R.; Karssemeijer, N.; Sz\\'ekely, G.

    2012-01-01

    False positive (FP) marks represent an obstacle for effective use of computer-aided detection (CADe) of breast masses in mammography. Typically, the problem can be approached either by developing more discriminative features or by employing different classifier designs. In this paper, the usage of s

  13. The Effects of Computer-Aided Concept Cartoons and Outdoor Science Activities on Light Pollution

    Science.gov (United States)

    Aydin, Güliz

    2015-01-01

    The purpose of this study is to create an awareness of light pollution on seventh grade students via computer aided concept cartoon applications and outdoor science activities and to help them develop solutions; and to determine student opinions on the practices carried out. The study was carried out at a middle school in Mugla province of Aegean…

  14. Persons with Alzheimer's Disease Make Phone Calls Independently Using a Computer-Aided Telephone System

    Science.gov (United States)

    Perilli, Viviana; Lancioni, Giulio E.; Singh, Nirbhay N.; O'Reilly, Mark F.; Sigafoos, Jeff; Cassano, Germana; Cordiano, Noemi; Pinto, Katia; Minervini, Mauro G.; Oliva, Doretta

    2012-01-01

    This study assessed whether four patients with a diagnosis of Alzheimer's disease could make independent phone calls via a computer-aided telephone system. The study was carried out according to a non-concurrent multiple baseline design across participants. All participants started with baseline during which the telephone system was not available,…

  15. [Comparison of two computer-aided recording systems: MT 1602 and Compugnath].

    Science.gov (United States)

    Pröbster, L; Benzing, U

    1990-07-01

    Two computer-aided jaw movement recording systems were compared with each other. The results showed that both systems work satisfactorily for use in reconstructive dentistry and TMJ diagnosis. It is, however, emphasized, that there are a number of shortcomings which may have a negative effect on the recordings.

  16. A Multidisciplinary Research Team Approach to Computer-Aided Drafting (CAD) System Selection. Final Report.

    Science.gov (United States)

    Franken, Ken; And Others

    A multidisciplinary research team was assembled to review existing computer-aided drafting (CAD) systems for the purpose of enabling staff in the Design Drafting Department at Linn Technical College (Missouri) to select the best system out of the many CAD systems in existence. During the initial stage of the evaluation project, researchers…

  17. Computer-Aided Detection in Breast Magnetic Resonance Imaging: A Review

    NARCIS (Netherlands)

    Dorrius, M. D.; Van Ooijen, P.M.A.

    2008-01-01

    The aim of this study is to give an overview on the accuracy of the discrimination between benign and malignant breast lesions on MRI with and without the use of a computer-aided detection (CAD) system. One investigator selected relevant articles based on title and abstract. Ten articles were select

  18. Computer-aided detection of small pulmonary nodules in chest radiographs: an observer study.

    NARCIS (Netherlands)

    Boo, D.W. De; Uffmann, M.; Weber, M.; Bipat, S.; Boorsma, E.F.; Scheerder, M.J.; Freling, N.J.; Schaefer-Prokop, C.M.

    2011-01-01

    RATIONALE AND OBJECTIVES: To evaluate the impact of computer-aided detection (CAD, IQQA-Chest; EDDA Technology, Princeton Junction, NJ) used as second reader on the detection of small pulmonary nodules in chest radiography (CXR). MATERIALS AND METHODS: A total of 113 patients (mean age 62 years) wit

  19. Computer Aided Design of Kaplan Turbine Piston with\tSolidWorks

    Directory of Open Access Journals (Sweden)

    Camelia Jianu

    2010-10-01

    Full Text Available The paper presents the steps for 3D computer aided design (CAD of Kaplan turbine piston made in SolidWorks.The present paper is a tutorial for a Kaplan turbine piston 3D geometry, which is dedicaded to the Parts Sketch and Parts Features design and Drawing Geometry and Drawing Annotation.

  20. Computer aided molecular design with combined molecular modeling and group contribution

    DEFF Research Database (Denmark)

    Harper, Peter Mathias; Gani, Rafiqul; Kolar, Petr

    1999-01-01

    Computer-aided molecular design (CAMD) provides a means for determining molecules or mixtures of molecules (CAMMD) having a desirable set of physicochemical properties. The application range of CAMD is restricted due to limitations on the complexity of the generated molecular structures and on th...

  1. Second Asia-Pacific Conference on the Computer Aided System Engineering

    CERN Document Server

    Chaczko, Zenon; Jacak, Witold; Łuba, Tadeusz; Computational Intelligence and Efficiency in Engineering Systems

    2015-01-01

    This carefully edited and reviewed volume addresses the increasingly popular demand for seeking more clarity in the data that we are immersed in. It offers excellent examples of the intelligent ubiquitous computation, as well as recent advances in systems engineering and informatics. The content represents state-of-the-art foundations for researchers in the domain of modern computation, computer science, system engineering and networking, with many examples that are set in industrial application context. The book includes the carefully selected best contributions to APCASE 2014, the 2nd Asia-Pacific Conference on  Computer Aided System Engineering, held February 10-12, 2014 in South Kuta, Bali, Indonesia. The book consists of four main parts that cover data-oriented engineering science research in a wide range of applications: computational models and knowledge discovery; communications networks and cloud computing; computer-based systems; and data-oriented and software-intensive systems.

  2. Computer-Aided Approaches for Targeting HIVgp41

    Directory of Open Access Journals (Sweden)

    William J. Allen

    2012-08-01

    Full Text Available Virus-cell fusion is the primary means by which the human immunodeficiency virus-1 (HIV delivers its genetic material into the human T-cell host. Fusion is mediated in large part by the viral glycoprotein 41 (gp41 which advances through four distinct conformational states: (i native, (ii pre-hairpin intermediate, (iii fusion active (fusogenic, and (iv post-fusion. The pre-hairpin intermediate is a particularly attractive step for therapeutic intervention given that gp41 N-terminal heptad repeat (NHR and C‑terminal heptad repeat (CHR domains are transiently exposed prior to the formation of a six-helix bundle required for fusion. Most peptide-based inhibitors, including the FDA‑approved drug T20, target the intermediate and there are significant efforts to develop small molecule alternatives. Here, we review current approaches to studying interactions of inhibitors with gp41 with an emphasis on atomic-level computer modeling methods including molecular dynamics, free energy analysis, and docking. Atomistic modeling yields a unique level of structural and energetic detail, complementary to experimental approaches, which will be important for the design of improved next generation anti-HIV drugs.

  3. Computer aided detection of oral lesions on CT images

    Science.gov (United States)

    Galib, S.; Islam, F.; Abir, M.; Lee, H. K.

    2015-12-01

    Oral lesions are important findings on computed tomography (CT) images. In this study, a fully automatic method to detect oral lesions in mandibular region from dental CT images is proposed. Two methods were developed to recognize two types of lesions namely (1) Close border (CB) lesions and (2) Open border (OB) lesions, which cover most of the lesion types that can be found on CT images. For the detection of CB lesions, fifteen features were extracted from each initial lesion candidates and multi layer perceptron (MLP) neural network was used to classify suspicious regions. Moreover, OB lesions were detected using a rule based image processing method, where no feature extraction or classification algorithm were used. The results were validated using a CT dataset of 52 patients, where 22 patients had abnormalities and 30 patients were normal. Using non-training dataset, CB detection algorithm yielded 71% sensitivity with 0.31 false positives per patient. Furthermore, OB detection algorithm achieved 100% sensitivity with 0.13 false positives per patient. Results suggest that, the proposed framework, which consists of two methods, has the potential to be used in clinical context, and assist radiologists for better diagnosis.

  4. Aiding Design of Wave Energy Converters via Computational Simulations

    Science.gov (United States)

    Jebeli Aqdam, Hejar; Ahmadi, Babak; Raessi, Mehdi; Tootkaboni, Mazdak

    2015-11-01

    With the increasing interest in renewable energy sources, wave energy converters will continue to gain attention as a viable alternative to current electricity production methods. It is therefore crucial to develop computational tools for the design and analysis of wave energy converters. A successful design requires balance between the design performance and cost. Here an analytical solution is used for the approximate analysis of interactions between a flap-type wave energy converter (WEC) and waves. The method is verified using other flow solvers and experimental test cases. Then the model is used in conjunction with a powerful heuristic optimization engine, Charged System Search (CSS) to explore the WEC design space. CSS is inspired by charged particles behavior. It searches the design space by considering candidate answers as charged particles and moving them based on the Coulomb's laws of electrostatics and Newton's laws of motion to find the global optimum. Finally the impacts of changes in different design parameters on the power takeout of the superior WEC designs are investigated. National Science Foundation, CBET-1236462.

  5. Integrated research of parallel computing: Status and future

    Institute of Scientific and Technical Information of China (English)

    CHEN GuoLiang; SUN GuangZhong; XU Yun; LONG Bai

    2009-01-01

    In the past twenty years, the research group in University of Science and Technology of China has de-veloped an integrated research method for parallel computing, which is a combination of "Architecture-Algorithm-Programming-Application". This method is also called the ecological environment of parallel computing research. In this paper, we survey the current status of integrated research method for par-allel computing and by combining the impact of multi-core systems, cloud computing and personal high performance computer, we present our outlook on the future development of parallel computing.

  6. Computer-aided detection for computed tomographic colonography screening: a prospective comparison of a double-reading paradigm with first-reader computer-aided detection against second-reader computer-aided detection.

    Science.gov (United States)

    Iussich, Gabriella; Correale, Loredana; Senore, Carlo; Hassan, Cesare; Segnan, Nereo; Campanella, Delia; Bert, Alberto; Galatola, Giovanni; Laudi, Cristiana; Regge, Daniele

    2014-03-01

    The objective of this study was to prospectively compare diagnostic performance and time efficiency of a double-reading paradigm in which a first-reader computer-aided detection (CAD) is followed by a fast 2-dimensional review (DR FR-CAD) with those of a double reading with second-reader CAD (SR CAD). The local ethical committee approved this study. Consecutive immunological patients who have positive results for fecal immunological test who were scheduled for colonoscopy were enrolled for a 10-month period. Computed tomographic colonography studies were read with CAD (CAD COLON-1.20; im3D, Turin, Italy) by using both SR CAD (applied after unassisted interpretation primary 2-dimensional) and DR FR-CAD (CAD-prompts evaluation followed by a fast 2-dimensional review) in randomized order with the radiologist for each reading paradigm masked to the other reader's results.Per-patient sensitivity and specificity of unassisted and CAD-assisted readings for detecting 6-mm adenomas or larger were calculated by using unblinding colonoscopy as reference standard. Reporting times were also calculated. Pairwise comparisons were performed. A total of 182 participants (median age, 65 years; range, 58-76) were included in the final analysis. Of these, 93 (51%) had at least 1 cancer or a 6-mm adenoma or larger. At the 6-mm threshold, sensitivity of unassisted reading (79.6%; 95% confidence interval [CI], 69.9-87.2) increased significantly with the use of both SR CAD (86.0%; 95% CI, 77.3%-92.3%) and DR FR-CAD (89.2%; 95% CI, 81.1%-94.7%), without differences between CAD readings (P = 0.500). No significant differences in specificity among the 3 paradigms were observed. Double reading with first-reader CAD required less reading time than that for SR CAD (378 vs 496; Δ118 seconds; P reader CAD is followed by a fast 2-dimensional review improves the adenoma detection rate to the same level achieved by a second-reader CAD while decreasing reporting times.

  7. Computer-Aided Drug Design (CADD): Methodological Aspects and Practical Applications in Cancer Research

    Science.gov (United States)

    Gianti, Eleonora

    Computer-Aided Drug Design (CADD) has deservedly gained increasing popularity in modern drug discovery (Schneider, G.; Fechner, U. 2005), whether applied to academic basic research or the pharmaceutical industry pipeline. In this work, after reviewing theoretical advancements in CADD, we integrated novel and stateof- the-art methods to assist in the design of small-molecule inhibitors of current cancer drug targets, specifically: Androgen Receptor (AR), a nuclear hormone receptor required for carcinogenesis of Prostate Cancer (PCa); Signal Transducer and Activator of Transcription 5 (STAT5), implicated in PCa progression; and Epstein-Barr Nuclear Antigen-1 (EBNA1), essential to the Epstein Barr Virus (EBV) during latent infections. Androgen Receptor. With the aim of generating binding mode hypotheses for a class (Handratta, V.D. et al. 2005) of dual AR/CYP17 inhibitors (CYP17 is a key enzyme for androgens biosynthesis and therefore implicated in PCa development), we successfully implemented a receptor-based computational strategy based on flexible receptor docking (Gianti, E.; Zauhar, R.J. 2012). Then, with the ultimate goal of identifying novel AR binders, we performed Virtual Screening (VS) by Fragment-Based Shape Signatures, an improved version of the original method developed in our Laboratory (Zauhar, R.J. et al. 2003), and we used the results to fully assess the high-level performance of this innovative tool in computational chemistry. STAT5. The SRC Homology 2 (SH2) domain of STAT5 is responsible for phospho-peptide recognition and activation. As a keystone of Structure-Based Drug Design (SBDD), we characterized key residues responsible for binding. We also generated a model of STAT5 receptor bound to a phospho-peptide ligand, which was validated by docking publicly known STAT5 inhibitors. Then, we performed Shape Signatures- and docking-based VS of the ZINC database (zinc.docking.org), followed by Molecular Mechanics Generalized Born Surface Area (MMGBSA

  8. The Computer-Aided Analytic Process Model. Operations Handbook for the APM (Analytic Process Model) Demonstration Package. Appendix

    Science.gov (United States)

    1986-01-01

    The Analytic Process Model for System Design and Measurement: A Computer-Aided Tool for Analyzing Training Systems and Other Human-Machine Systems. A...separate companion volume--The Computer-Aided Analytic Process Model : Operations Handbook for the APM Demonstration Package is also available under

  9. Medical image computing and computer-aided medical interventions applied to soft tissues. Work in progress in urology

    CERN Document Server

    Troccaz, Jocelyne; Berkelman, Peter; Cinquin, Philippe; Daanen, Vincent; Leroy, Antoine; Marchal, Maud; Payan, Yohan; Promayon, Emmanuel; Voros, Sandrine; Bart, Stéphane; Bolla, Michel; Chartier-Kastler, Emmanuel; Descotes, Jean-Luc; Dusserre, Andrée; Giraud, Jean-Yves; Long, Jean-Alexandre; Moalic, Ronan; Mozer, Pierre

    2006-01-01

    Until recently, Computer-Aided Medical Interventions (CAMI) and Medical Robotics have focused on rigid and non deformable anatomical structures. Nowadays, special attention is paid to soft tissues, raising complex issues due to their mobility and deformation. Mini-invasive digestive surgery was probably one of the first fields where soft tissues were handled through the development of simulators, tracking of anatomical structures and specific assistance robots. However, other clinical domains, for instance urology, are concerned. Indeed, laparoscopic surgery, new tumour destruction techniques (e.g. HIFU, radiofrequency, or cryoablation), increasingly early detection of cancer, and use of interventional and diagnostic imaging modalities, recently opened new challenges to the urologist and scientists involved in CAMI. This resulted in the last five years in a very significant increase of research and developments of computer-aided urology systems. In this paper, we propose a description of the main problems rel...

  10. Computer-aided process planning in prismatic shape die components based on Standard for the Exchange of Product model data

    Directory of Open Access Journals (Sweden)

    Awais Ahmad Khan

    2015-11-01

    Full Text Available Insufficient technologies made good integration between the die components in design, process planning, and manufacturing impossible in the past few years. Nowadays, the advanced technologies based on Standard for the Exchange of Product model data are making it possible. This article discusses the three main steps for achieving the complete process planning for prismatic parts of the die components. These three steps are data extraction, feature recognition, and process planning. The proposed computer-aided process planning system works as part of an integrated system to cover the process planning of any prismatic part die component. The system is built using Visual Basic with EWDraw system for visualizing the Standard for the Exchange of Product model data file. The system works successfully and can cover any type of sheet metal die components. The case study discussed in this article is taken from a large design of progressive die.

  11. Computer-aided Nonlinear Control System Design Using Describing Function Models

    CERN Document Server

    Nassirharand, Amir

    2012-01-01

    A systematic computer-aided approach provides a versatile setting for the control engineer to overcome the complications of controller design for highly nonlinear systems. Computer-aided Nonlinear Control System Design provides such an approach based on the use of describing functions. The text deals with a large class of nonlinear systems without restrictions on the system order, the number of inputs and/or outputs or the number, type or arrangement of nonlinear terms. The strongly software-oriented methods detailed facilitate fulfillment of tight performance requirements and help the designer to think in purely nonlinear terms, avoiding the expedient of linearization which can impose substantial and unrealistic model limitations and drive up the cost of the final product. Design procedures are presented in a step-by-step algorithmic format each step being a functional unit with outputs that drive the other steps. This procedure may be easily implemented on a digital computer with example problems from mecha...

  12. Computer-Based Integrated Learning Systems: Research and Theory.

    Science.gov (United States)

    Hativa, Nira, Ed.; Becker, Henry Jay, Ed.

    1994-01-01

    The eight chapters of this theme issue discuss recent research and theory concerning computer-based integrated learning systems. Following an introduction about their theoretical background and current use in schools, the effects of using computer-based integrated learning systems in the elementary school classroom are considered. (SLD)

  13. AGIS: Integration of new technologies used in ATLAS Distributed Computing

    CERN Document Server

    Anisenkov, Alexey; The ATLAS collaboration; Alandes Pradillo, Maria

    2016-01-01

    AGIS is the information system designed to integrate configuration and status information about resources, services and topology of the computing infrastructure used by ATLAS Distributed Computing (ADC) applications and services. In this note, we describe the evolution and the recent developments of AGIS functionalities, related to integration of new technologies recently become widely used in ATLAS Computing like flexible computing utilization of opportunistic Cloud and HPC resources, ObjectStore services integration for Distributed Data Management (Rucio) and ATLAS workload management (PanDA) systems, unified storage protocols declaration required for PandDA Pilot site movers and others.

  14. Large-scale validation of a computer-aided polyp detection algorithm for CT colonography using cluster computing

    Science.gov (United States)

    Bitter, Ingmar; Brown, John E.; Brickman, Daniel; Summers, Ronald M.

    2004-04-01

    The presented method significantly reduces the time necessary to validate a computed tomographic colonography (CTC) computer aided detection (CAD) algorithm of colonic polyps applied to a large patient database. As the algorithm is being developed on Windows PCs and our target, a Beowulf cluster, is running on Linux PCs, we made the application dual platform compatible using a single source code tree. To maintain, share, and deploy source code, we used CVS (concurrent versions system) software. We built the libraries from their sources for each operating system. Next, we made the CTC CAD algorithm dual-platform compatible and validate that both Windows and Linux produced the same results. Eliminating system dependencies was mostly achieved using the Qt programming library, which encapsulates most of the system dependent functionality in order to present the same interface on either platform. Finally, we wrote scripts to execute the CTC CAD algorithm in parallel. Running hundreds of simultaneous copies of the CTC CAD algorithm on a Beowulf cluster computing network enables execution in less than four hours on our entire collection of over 2400 CT scans, as compared to a month a single PC. As a consequence, our complete patient database can be processed daily, boosting research productivity. Large scale validation of a computer aided polyp detection algorithm for CT colonography using cluster computing significantly improves the round trip time of algorithm improvement and revalidation.

  15. Application of CT-PSF-based computer-simulated lung nodules for evaluating the accuracy of computer-aided volumetry.

    Science.gov (United States)

    Funaki, Ayumu; Ohkubo, Masaki; Wada, Shinichi; Murao, Kohei; Matsumoto, Toru; Niizuma, Shinji

    2012-07-01

    With the wide dissemination of computed tomography (CT) screening for lung cancer, measuring the nodule volume accurately with computer-aided volumetry software is increasingly important. Many studies for determining the accuracy of volumetry software have been performed using a phantom with artificial nodules. These phantom studies are limited, however, in their ability to reproduce the nodules both accurately and in the variety of sizes and densities required. Therefore, we propose a new approach of using computer-simulated nodules based on the point spread function measured in a CT system. The validity of the proposed method was confirmed by the excellent agreement obtained between computer-simulated nodules and phantom nodules regarding the volume measurements. A practical clinical evaluation of the accuracy of volumetry software was achieved by adding simulated nodules onto clinical lung images, including noise and artifacts. The tested volumetry software was revealed to be accurate within an error of 20 % for nodules >5 mm and with the difference between nodule density and background (lung) (CT value) being 400-600 HU. Such a detailed analysis can provide clinically useful information on the use of volumetry software in CT screening for lung cancer. We concluded that the proposed method is effective for evaluating the performance of computer-aided volumetry software.

  16. Planning tools for environmental-orientated technology management - computer aided lifecycle analysis; Planungshilfsmittel fuer das oekologieorientierte Technologiemanagement - Computer Aided Lifecycle Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Boehlke, U.H. [Fraunhofer-Institut fuer Produktionstechnologie, Aachen (Germany); Eversheim, W.; Albrecht, T.

    1995-12-31

    The high pressure on prices in the automotive industry as well as the aim to improve the ecological tolerance of the individual motor car traffic requires a considerate employment of natural ressources. In this connection the selection of material is of special improtance. Due to the systematic recording and evaluation of appropriate requirements of ressources, decissions concerning the selection of material and technology can be supported with a product-related and comprehensive balance in kind. The EDV-prototype CALA (Computer Aided Lifecycle Analysis) was developed in order to reduce the effort of a balance in kind to a minimum. CALA supports the user in capturing data and data processing through a dialogue-oriented display mask and through providing of relevant ecological master data. (orig.) [Deutsch] Sowohl der hohe Kostendruck in der Automobilbranche als auch das Ziel die oekologische Vertraeglichkeit des Individualverkehrs zu verbessern, erfordern einen schonenden Einsatz der natuerlichen Ressourcen. Eine besondere Bedeutung kommt dabei der Werkstoffauswahl zu. Mit einer produktbezogenen, ganzheitlichen Sachbilanzierung koennen, durch die systematische Erfassung und Bewertung entsprechender Ressourcenbedarfe und Umweltbelastungen, Entscheidungen bei der Werkstoff- oder Technologieauswahl unterstuetzt werden. Um den Aufwand bei der Durchfuehrung einer Sachbilanzierung zu minimieren, wurde der EDV-Prototyp CALA (Computer Aided Lifecycle Analysis) entwickelt. Der Anwender wird bei CALA durch dialogorientierte Bildschirmmasken und die Bereitstellung oekologisch relevanter Stammdaten bei der Datenerfassung und Auswertung effektiv unterstuetzt. (orig.)

  17. Evaluation of marginal/internal fit of chrome-cobalt crowns: Direct laser metal sintering versus computer-aided design and computer-aided manufacturing.

    Science.gov (United States)

    Gunsoy, S; Ulusoy, M

    2016-01-01

    The purpose of this study was to evaluate the internal and marginal fit of chrome cobalt (Co-Cr) crowns were fabricated with laser sintering, computer-aided design (CAD) and computer-aided manufacturing, and conventional methods. Polyamide master and working models were designed and fabricated. The models were initially designed with a software application for three-dimensional (3D) CAD (Maya, Autodesk Inc.). All models were fabricated models were produced by a 3D printer (EOSINT P380 SLS, EOS). 128 1-unit Co-Cr fixed dental prostheses were fabricated with four different techniques: Conventional lost wax method, milled wax with lost-wax method (MWLW), direct laser metal sintering (DLMS), and milled Co-Cr (MCo-Cr). The cement film thickness of the marginal and internal gaps was measured by an observer using a stereomicroscope after taking digital photos in ×24. Best fit rates according to mean and standard deviations of all measurements was in DLMS both in premolar (65.84) and molar (58.38) models in μm. A significant difference was found DLMS and the rest of fabrication techniques (P 0.05). DMLS was best fitting fabrication techniques for single crown based on the results.The best fit was found in marginal; the larger gap was found in occlusal.All groups were within the clinically acceptable misfit range.

  18. A Patient Monitoring Tool For An HIV/AIDS Integral Care Model

    Science.gov (United States)

    2007-11-02

    AIDS INTEGRAL CARE MODEL C. Cáceres, E.J. Gómez, F. Del Pozo Grupo de Bioingeniería y Telemedicina , Universidad Politécnica de Madrid, Madrid...Performing Organization Name(s) and Address(es) Grupo de Bioingenieria y Telemedicina Universidad Politecnica de Madrid Madrid, Spain Performing

  19. Binaural Integrated Active Noise Control and Noise Reduction in Hearing Aids

    DEFF Research Database (Denmark)

    Serizel, Romain; Moonen, Marc; Wouters, Jan;

    2013-01-01

    This paper presents a binaural approach to integrated active noise control and noise reduction in hearing aids and aims at demonstrating that a binaural setup indeed provides significant advantages in terms of the number of noise sources that can be compensated for and in terms of the causality...

  20. Computer science in Dutch secondary education: independent or integrated?

    NARCIS (Netherlands)

    Sijde, van der Pieter C.; Doornekamp, B. Gerard

    1992-01-01

    Nowadays, in Dutch secondary education, computer science is integrated within school subjects. About ten years ago computer science was considered an independent subject, but in the mid-1980s this idea changed. In our study we investigated whether the objectives of teaching computer science as an in

  1. Computer science in Dutch secondary education: independent or integrated?

    NARCIS (Netherlands)

    van der Sijde, Peter; Doornekamp, B.G.

    1992-01-01

    Nowadays, in Dutch secondary education, computer science is integrated within school subjects. About ten years ago computer science was considered an independent subject, but in the mid-1980s this idea changed. In our study we investigated whether the objectives of teaching computer science as an

  2. Integrating Computer Ethics across the Curriculum: A Case Study

    Science.gov (United States)

    Ben-Jacob, Marion G.

    2005-01-01

    There is an increased use of computers in the educational environment of today that compels educators and learners to be informed about computer ethics and the related social and legal issues. This paper addresses different approaches for integrating computer ethics across the curriculum. Included are ideas for online and on-site workshops, the…

  3. Final technical report for DOE Computational Nanoscience Project: Integrated Multiscale Modeling of Molecular Computing Devices

    Energy Technology Data Exchange (ETDEWEB)

    Cummings, P. T.

    2010-02-08

    This document reports the outcomes of the Computational Nanoscience Project, "Integrated Multiscale Modeling of Molecular Computing Devices". It includes a list of participants and publications arising from the research supported.

  4. Unit cell-based computer-aided manufacturing system for tissue engineering.

    Science.gov (United States)

    Kang, Hyun-Wook; Park, Jeong Hun; Kang, Tae-Yun; Seol, Young-Joon; Cho, Dong-Woo

    2012-03-01

    Scaffolds play an important role in the regeneration of artificial tissues or organs. A scaffold is a porous structure with a micro-scale inner architecture in the range of several to several hundreds of micrometers. Therefore, computer-aided construction of scaffolds should provide sophisticated functionality for porous structure design and a tool path generation strategy that can achieve micro-scale architecture. In this study, a new unit cell-based computer-aided manufacturing (CAM) system was developed for the automated design and fabrication of a porous structure with micro-scale inner architecture that can be applied to composite tissue regeneration. The CAM system was developed by first defining a data structure for the computing process of a unit cell representing a single pore structure. Next, an algorithm and software were developed and applied to construct porous structures with a single or multiple pore design using solid freeform fabrication technology and a 3D tooth/spine computer-aided design model. We showed that this system is quite feasible for the design and fabrication of a scaffold for tissue engineering.

  5. Computer-aided approach for customized cell-based defect reconstruction.

    Science.gov (United States)

    Meyer, Ulrich; Neunzehn, Jörg; Wiesmann, Hans Peter

    2012-01-01

    Computer-aided technologies like computer-aided design (CAD), computer-aided manufacturing (CAM), and a lot of other features like finite element method (FEM) have been recently employed for use in medical ways like in extracorporeal bone tissue engineering strategies. Aim of this pilot experimental study was to test whether autologous osteoblast-like cells cultured in vitro on individualized scaffolds can be used to support bone regeneration in a clinical environment. Mandibular bone defects were surgically introduced into the mandibles of Göttinger minipigs and the scaffold of the defect site was modelled by CAD/CAM techniques. From the minipigs harvested autologous bone cells from the porcine calvaria were cultivated in bioreactors. The cultured osteoblast-like cells were seeded on polylactic acid/polyglycolic acid (PLA/PGA) copolymer scaffolds being generated by rapid prototyping. The bone defects were then reconstructed by implanting these tissue-constructs into bone defects. The postoperative computerized topographic scans as well as the intraoperative sites demonstrated the accurate fit in the defect sites. The individual created, implanted scaffold constructs enriched with the porcine osteoblast-like cells were well tolerated and appeared to support bone formation, as revealed by immunohistochemical and histological analyses. The results of this investigations indicated that the in vitro expanded osteoblast-like cells spread on a resorbable individualized, computer-aided fabricated scaffold is capable of promoting the repair of bone tissue defects in vivo. The shown results warrant further attempts to combine computer modelling and tissue engineering for use in different ways in bone reconstructive surgery.

  6. A systematic framework for computer-aided design of engineering rubber formulations

    Science.gov (United States)

    Ghosh, Prasenjeet

    This thesis considers the design of engineering rubber formulations, whose unique properties of elasticity and resilience enable diverse applications. Engineering rubber formulations are a complex mixture of different materials called curatives that includes elastomers, fillers, crosslinking agents, accelerators, activators, retarders, anti-oxidants and processing aids, where the amount of curatives must be adjusted for each application. The characterization of the final properties of the rubber in application is complex and depends on the chemical interplay between the different curatives in formulation via vulcanization chemistry. The details of the processing conditions and the thermal, deformational, and chemical environment encountered in application also have a pronounced effect on the performance of the rubber. Consequently, for much of the history of rubber as an engineering material, its recipe formulations have been developed largely by trial-and-error, rather than by a fundamental understanding. A computer-aided, systematic and automated framework for the design of such materials is proposed in this thesis. The framework requires the solution to two sub-problems: (a) the forward problem, which involves prediction of the desired properties when the formulation is known and (b) the inverse problem that requires identification of the appropriate formulation, given the desired target properties. As part of the forward model, the chemistry of accelerated sulfur vulcanization is reviewed that permits integration of the knowledge of the past five decades in the literature to answer some old questions, reconcile some of the contradicting mechanisms and present a holistic description of the governing chemistry. Based on this mechanistic chemistry, a fundamental kinetic model is derived using population balance equations. The model quantitatively describes, for the first time, the different aspects of vulcanization chemistry. Subsequently, a novel three

  7. GPS Estimates of Integrated Precipitable Water Aid Weather Forecasters

    Science.gov (United States)

    Moore, Angelyn W.; Gutman, Seth I.; Holub, Kirk; Bock, Yehuda; Danielson, David; Laber, Jayme; Small, Ivory

    2013-01-01

    Global Positioning System (GPS) meteorology provides enhanced density, low-latency (30-min resolution), integrated precipitable water (IPW) estimates to NOAA NWS (National Oceanic and Atmospheric Adminis tration Nat ional Weather Service) Weather Forecast Offices (WFOs) to provide improved model and satellite data verification capability and more accurate forecasts of extreme weather such as flooding. An early activity of this project was to increase the number of stations contributing to the NOAA Earth System Research Laboratory (ESRL) GPS meteorology observing network in Southern California by about 27 stations. Following this, the Los Angeles/Oxnard and San Diego WFOs began using the enhanced GPS-based IPW measurements provided by ESRL in the 2012 and 2013 monsoon seasons. Forecasters found GPS IPW to be an effective tool in evaluating model performance, and in monitoring monsoon development between weather model runs for improved flood forecasting. GPS stations are multi-purpose, and routine processing for position solutions also yields estimates of tropospheric zenith delays, which can be converted into mm-accuracy PWV (precipitable water vapor) using in situ pressure and temperature measurements, the basis for GPS meteorology. NOAA ESRL has implemented this concept with a nationwide distribution of more than 300 "GPSMet" stations providing IPW estimates at sub-hourly resolution currently used in operational weather models in the U.S.

  8. CALL与教师的角色%Computer-Aided Second Language Learning (CALL) and the Role of Teachers

    Institute of Scientific and Technical Information of China (English)

    肖建新

    2004-01-01

    High technology, especially the use of computers, has won a secure place among the resources available to the modern language teacher because of its prominent advantages. However, despite the great interest shown by their students, many teachers remain uncommitted to computer-assisted language learning, not only because of their lack of computer knowledge themselves, but the integrated disadvantages of computer itself. This article argues that teachers are still needed to drive the computer-aided language learning process and that the teacher's role will not be threatened at all.%在现代语言教师所能获得的众多的教学手段中,计算机多媒体等现代教育技术已经牢牢地获得了一席之地.然而,尽管在这方面已经投入巨额资金,学生对这一教学手段也显出极大的兴趣,许多教师对计算机辅助语言学习仍然持怀疑态度.文章对此现象进行了探讨,提出了一些解决措施,主张应该由教师决定计算机辅助语言学习的进程.

  9. Modeling uncertainty in classification design of a computer-aided detection system

    Science.gov (United States)

    Hosseini, Rahil; Dehmeshki, Jamshid; Barman, Sarah; Mazinani, Mahdi; Qanadli, Salah

    2010-03-01

    A computerized image analysis technology suffers from imperfection, imprecision and vagueness of the input data and its propagation in all individual components of the technology including image enhancement, segmentation and pattern recognition. Furthermore, a Computerized Medical Image Analysis System (CMIAS) such as computer aided detection (CAD) technology deals with another source of uncertainty that is inherent in image-based practice of medicine. While there are several technology-oriented studies reported in developing CAD applications, no attempt has been made to address, model and integrate these types of uncertainty in the design of the system components, even though uncertainty issues directly affect the performance and its accuracy. In this paper, the main uncertainty paradigms associated with CAD technologies are addressed. The influence of the vagueness and imprecision in the classification of the CAD, as a second reader, on the validity of ROC analysis results is defined. In order to tackle the problem of uncertainty in the classification design of the CAD, two fuzzy methods are applied and evaluated for a lung nodule CAD application. Type-1 fuzzy logic system (T1FLS) and an extension of it, interval type-2 fuzzy logic system (IT2FLS) are employed as methods with high potential for managing uncertainty issues. The novelty of the proposed classification methods is to address and handle all sources of uncertainty associated with a CAD system. The results reveal that IT2FLS is superior to T1FLS for tackling all sources of uncertainty and significantly, the problem of inter and intra operator observer variability.

  10. A portable image overlay projection device for computer-aided open liver surgery.

    Science.gov (United States)

    Gavaghan, Kate A; Peterhans, Matthias; Oliveira-Santos, Thiago; Weber, Stefan

    2011-06-01

    Image overlay projection is a form of augmented reality that allows surgeons to view underlying anatomical structures directly on the patient surface. It improves intuitiveness of computer-aided surgery by removing the need for sight diversion between the patient and a display screen and has been reported to assist in 3-D understanding of anatomical structures and the identification of target and critical structures. Challenges in the development of image overlay technologies for surgery remain in the projection setup. Calibration, patient registration, view direction, and projection obstruction remain unsolved limitations to image overlay techniques. In this paper, we propose a novel, portable, and handheld-navigated image overlay device based on miniature laser projection technology that allows images of 3-D patient-specific models to be projected directly onto the organ surface intraoperatively without the need for intrusive hardware around the surgical site. The device can be integrated into a navigation system, thereby exploiting existing patient registration and model generation solutions. The position of the device is tracked by the navigation system's position sensor and used to project geometrically correct images from any position within the workspace of the navigation system. The projector was calibrated using modified camera calibration techniques and images for projection are rendered using a virtual camera defined by the projectors extrinsic parameters. Verification of the device's projection accuracy concluded a mean projection error of 1.3 mm. Visibility testing of the projection performed on pig liver tissue found the device suitable for the display of anatomical structures on the organ surface. The feasibility of use within the surgical workflow was assessed during open liver surgery. We show that the device could be quickly and unobtrusively deployed within the sterile environment.

  11. Creating a semantic lesion database for computer-aided MR mammography

    Science.gov (United States)

    Wang, Xiaogang; Martel, Anne

    2012-02-01

    This work presents the creation of a semantic lesion database which will support research into computer-aided lesion detection (CAD) in breast screening MRI. As an adjunct to conventional X-ray mammography, MR-mammography has become a popular screening tool for women with a high risk of breast cancer because of its high sensitivity in detecting malignancy. To address the needs of research and development into CAD for breast MRI an integrated tool has been designed to collect all lesion related information, conduct quantitative analysis, and then present crucial data to clinicians and researchers. A lesion database is an essential component of this system as it provides a link between the DICOM database of MR images and the meta-information contained in the Electronic Patient Record. The patient history, radiology reports from MRI screening visits and pathology reports are all collected, dissected, and stored in a hierarchical structure in the database. Moreover, internal links between pathology specimens and the location of the corresponding lesion in the image are established allowing diagnostic information to be displayed alongside the relevant images. If "ground truth" for an imaging visit can be established either by biopsy or by 2-year follow-up, then the case is labeled as suitable for use in training and testing CAD algorithms. At present a total of 1882 lesions (benign/malignant), 200 pathology specimens over 405 subjects and 1794 screening (455 CAD studies) are included in the database. As well as providing an excellent resource for CAD development this also has potential applications in resident radiologists' training and education.

  12. Computer-aided diagnosis of knee-joint disorders via vibroarthrographic signal analysis: a review.

    Science.gov (United States)

    Wu, Yunfeng; Krishnan, Sridhar; Rangayyan, Rangaraj M

    2010-01-01

    The knee is the lower-extremity joint that supports nearly the entire weight of the human body. It is susceptible to osteoarthritis and other knee-joint disorders caused by degeneration or loss of articular cartilage. The detection of a knee-joint abnormality at an early stage is important, because it helps increase therapeutic options that may slow down the degenerative process. Imaging-based arthrographic modalities can provide anatomical images of the joint cartilage surfaces, but fail to demonstrate the functional integrity of the cartilage. Knee-joint auscultation, by means of recording the vibroarthrographic (VAG) signal during bending motion of a knee, could be used to develop a noninvasive diagnostic tool. Computer-aided analysis of VAG signals could provide quantitative indices for screening of degenerative conditions of the cartilage surface and staging of osteoarthritis. In addition, the diagnosis of knee-joint pathology by means of VAG signal analysis may reduce the number of semi-invasive diagnostic arthroscopic examinations. This article reviews studies related to VAG signal analysis, first summarizing the pilot studies that demonstrated the diagnostic potential of knee-joint auscultation for the detection of degenerative diseases, and then describing the details of recent progress in analysis of VAG signals using temporal analysis, frequency-domain analysis, time-frequency analysis, and statistical modeling. The decision-making methods used in the related studies are summarized, followed by a comparison of the diagnostic performance achieved by different pattern classifiers. The final section is a perspective on the future and further development of VAG signal analysis.

  13. Computer aided reliability, availability, and safety modeling for fault-tolerant computer systems with commentary on the HARP program

    Science.gov (United States)

    Shooman, Martin L.

    1991-01-01

    Many of the most challenging reliability problems of our present decade involve complex distributed systems such as interconnected telephone switching computers, air traffic control centers, aircraft and space vehicles, and local area and wide area computer networks. In addition to the challenge of complexity, modern fault-tolerant computer systems require very high levels of reliability, e.g., avionic computers with MTTF goals of one billion hours. Most analysts find that it is too difficult to model such complex systems without computer aided design programs. In response to this need, NASA has developed a suite of computer aided reliability modeling programs beginning with CARE 3 and including a group of new programs such as: HARP, HARP-PC, Reliability Analysts Workbench (Combination of model solvers SURE, STEM, PAWS, and common front-end model ASSIST), and the Fault Tree Compiler. The HARP program is studied and how well the user can model systems using this program is investigated. One of the important objectives will be to study how user friendly this program is, e.g., how easy it is to model the system, provide the input information, and interpret the results. The experiences of the author and his graduate students who used HARP in two graduate courses are described. Some brief comparisons were made with the ARIES program which the students also used. Theoretical studies of the modeling techniques used in HARP are also included. Of course no answer can be any more accurate than the fidelity of the model, thus an Appendix is included which discusses modeling accuracy. A broad viewpoint is taken and all problems which occurred in the use of HARP are discussed. Such problems include: computer system problems, installation manual problems, user manual problems, program inconsistencies, program limitations, confusing notation, long run times, accuracy problems, etc.

  14. Simultaneous Computer-Aided Design/Computer-Aided Manufacture Bimaxillary Orthognathic Surgery and Mandibular Reconstruction Using Selective-Laser Sintered Titanium Implant.

    Science.gov (United States)

    Hatamleh, Muhanad M; Bhamrah, Gurprit; Ryba, Francine; Mack, Gavin; Huppa, Chrisopher

    2016-10-01

    This patient report describes simultaneous bimaxillary orthognathic surgery and mandibular reconstruction by means of three-dimensional (3D) planning, 3D printed biocompatible surgical wafers, and 3D selective-laser sintered titanium implant. A 26-year-old male patient presented with a left mandibular defect secondary to trauma. The whole body of the mandible on the left hand side was deficient with a narrow connection with the remaining left condyle. He had undergone orthodontic treatment for 18 months and was ready to undergo bimaxillary orthognathic surgery. Advanced cranio-maxillofacial software was used in processing his cone beam computer tomography scan data, and e-casts of his upper and lower dental arches. Bimaxillary surgery was planned with Le Fort 1 maxillary impaction and mandibular advancement to achieve a class 1 incisor relationship. Intermediate and final surgical wafers were designed following the planned movements and printed using biocompatible resin. The deficient left side of the mandible was reconstructed by means of mirror imaging the contra-lateral right side into the deficient left side with the aim of restoring normal facial symmetry. Biomedical software was then used in designing a reconstruction plate that connected the condylar head and the mandible following the planned bimaxillary surgery and mandibular continuity symmetry reconstruction. The plate was printed in titanium following state-of the-art selective laser sintering technology. The bimaxillary surgery and mandibular reconstruction were done simultaneously as planned along with an iliac-crest bone graft. This patient confirms the advantages of 3D computer-aided design/computer-aided manufacture technologies in optimizing clinical outcomes for cranio-maxillofacial reconstruction, especially when conducting two simultaneous clinical procedures.

  15. Evaluation of three-dimensional position change of the condylar head after orthognathic surgery using computer-aided design/computer-aided manufacturing-made condyle positioning jig.

    Science.gov (United States)

    Kim, Hyung-Mo; Baek, Seung-Hak; Kim, Tae-Yun; Choi, Jin-Young

    2014-11-01

    This study was performed to evaluate the efficacy of computer-aided design/computer-aided manufacturing (CAM/CAD)-made condyle positioning jig in orthognathic surgery. The sample consisted of 40 mandibular condyles of 20 patients with class III malocclusion who underwent bilateral sagittal split ramus osteotomy with semirigid fixation (6 men and 14 women; mean age, 25 y; mean amount of mandibular setback, 5.8 mm). Exclusion criteria were patients who needed surgical correction of the frontal ramal inclination and had signs and symptoms of the temporomandibular disorder before surgery. Three-dimensional computed tomograms were taken 1 month before the surgery (T1) and 1 day after the surgery (T2). The condylar position was evaluated at the T1 and T2 stages on the axial, frontal, and sagittal aspects in the three-dimensional coordinates. The linear change of the posterior border of the proximal segment of the ramus between T1 and T2 was also evaluated in 30 condyles (15 patients), with the exception of 10 condyles of 5 patients who received mandibular angle reduction surgery. There was no significant difference in the condylar position in the frontal and sagittal aspects (P > 0.05). Although there was a significant difference in the condylar position in the axial aspect (P < 0.01), the amount of difference was less than 1 mm and 1 degree; it can be considered clinically nonsignificant. In the linear change of the posterior border of the proximal segment of the ramus, the mean change was 1.4 mm and 60% of the samples showed a minimal change of less than 1 mm. The results of this study suggest that CAD/CAM-made condyle positioning jig is easy to install and reliable to use in orthognathic surgery.

  16. Computer-aided system for hazard zone identification in ship power plants

    Institute of Scientific and Technical Information of China (English)

    PODSIADLO A; TARELKO W

    2005-01-01

    The most dangerous places in ships are their power plants. Particularly, they are very unsafe for operators carrying out various necessary operation and maintenance activities. For this reason, ship machinery should be designed to ensure the maximum safety for its operators. It is a very difficult task. Therefore, it could not be solved by means of conventional design methods, which are used for design of uncomplicated technical equipment. One of the possible ways of solving this problem is to provide appropriate tools, which allow us to take the operator's safety into account during a design process, especially at its early stages. A computer-aided system supporting design of safe ship power plants could be such a tool. This paper deals with developing process of a prototype of the computer-aided system for hazard zone identification in ship power plants.

  17. Computer-aided analysis and design of the shape rolling process for producing turbine engine airfoils

    Science.gov (United States)

    Lahoti, G. D.; Akgerman, N.; Altan, T.

    1978-01-01

    Mild steel (AISI 1018) was selected as model cold rolling material and Ti-6A1-4V and Inconel 718 were selected as typical hot rolling and cold rolling alloys, respectively. The flow stress and workability of these alloys were characterized and friction factor at the roll/workpiece interface was determined at their respective working conditions by conducting ring tests. Computer-aided mathematical models for predicting metal flow and stresses, and for simulating the shape rolling process were developed. These models utilized the upper bound and the slab methods of analysis, and were capable of predicting the lateral spread, roll separating force, roll torque, and local stresses, strains and strain rates. This computer-aided design system was also capable of simulating the actual rolling process, and thereby designing the roll pass schedule in rolling of an airfoil or a similar shape.

  18. Automatic pterygium detection on cornea images to enhance computer-aided cortical cataract grading system.

    Science.gov (United States)

    Gao, Xinting; Wong, Damon Wing Kee; Aryaputera, Aloysius Wishnu; Sun, Ying; Cheng, Ching-Yu; Cheung, Carol; Wong, Tien Yin

    2012-01-01

    In this paper, we present a new method to detect pterygiums using cornea images. Due to the similarity of appearances and spatial locations between pterygiums and cortical cataracts, pterygiums are often falsely detected as cortical cataracts on retroillumination images by a computer-aided grading system. The proposed method can be used to filter out the pterygium which improves the accuracy of cortical cataract grading system. This work has three major contributions. First, we propose a new pupil segmentation method for visible wavelength images. Second, an automatic detection method of pterygiums is proposed. Third, we develop an enhanced compute-aided cortical cataract grading system that excludes pterygiums. The proposed method is tested using clinical data and the experimental results demonstrate that the proposed method can improve the existing automatic cortical cataract grading system.

  19. Computer aided virtual manufacturing using Creo parametric easy to learn step by step guide

    CERN Document Server

    Kanife, Paul Obiora

    2016-01-01

    Providing a step-by-step guide for the implementation of virtual manufacturing using Creo Parametric software (formerly known as Pro-Engineer), this book creates an engaging and interactive learning experience for manufacturing engineering students. Featuring graphic illustrations of simulation processes and operations, and written in accessible English to promote user-friendliness, the book covers key topics in the field including: the engraving machining process, face milling, profile milling, surface milling, volume rough milling, expert machining, electric discharge machining (EDM), and area turning using the lathe machining process. Maximising reader insights into how to simulate material removal processes, and how to generate cutter location data and G-codes data, this valuable resource equips undergraduate, postgraduate, BTech and HND students in the fields of manufacturing engineering, computer aided design (CAD) and computer aided engineering (CAE) with transferable skills and knowledge. This book is...

  20. Computer-Aided Design Method of Warp-Knitted Jacquard Spacer Fabrics

    Directory of Open Access Journals (Sweden)

    Li Xinxin

    2016-06-01

    Full Text Available Based on a further study on knitting and jacquard principles, this paper presents a mathematical design model to make computer-aided design of warp-knitted jacquard spacer fabrics more efficient. The mathematical model with matrix method employs three essential elements of chain notation, threading and Jacquard designing. With this model, the processing to design warp-knitted jacquard spacer fabrics with CAD software is also introduced. In this study, the sports shoes which have separated functional areas according to the feet structure and characteristics of movement are analysed. The results show the different patterns on Jacquard spacer fabrics that are seamlessly stitched with jacquard technics. The computer-aided design method of warp-knitted jacquard spacer fabrics is efficient and simple.