WorldWideScience

Sample records for comprehensive approach yields

  1. NEST: a comprehensive model for scintillation yield in liquid xenon

    Energy Technology Data Exchange (ETDEWEB)

    Szydagis, M; Barry, N; Mock, J; Stolp, D; Sweany, M; Tripathi, M; Uvarov, S; Walsh, N; Woods, M [University of California, Davis, One Shields Ave., Davis, CA 95616 (United States); Kazkaz, K, E-mail: mmszydagis@ucdavis.edu [Lawrence Livermore National Laboratory, 7000 East Ave., Livermore, CA 94550 (United States)

    2011-10-15

    A comprehensive model for explaining scintillation yield in liquid xenon is introduced. We unify various definitions of work function which abound in the literature and incorporate all available data on electron recoil scintillation yield. This results in a better understanding of electron recoil, and facilitates an improved description of nuclear recoil. An incident gamma energy range of O(1 keV) to O(1 MeV) and electric fields between 0 and O(10 kV/cm) are incorporated into this heuristic model. We show results from a Geant4 implementation, but because the model has a few free parameters, implementation in any simulation package should be simple. We use a quasi-empirical approach with an objective of improving detector calibrations and performance verification. The model will aid in the design and optimization of future detectors. This model is also easy to extend to other noble elements. In this paper we lay the foundation for an exhaustive simulation code which we call NEST (Noble Element Simulation Technique).

  2. NEST: a comprehensive model for scintillation yield in liquid xenon

    International Nuclear Information System (INIS)

    Szydagis, M; Barry, N; Mock, J; Stolp, D; Sweany, M; Tripathi, M; Uvarov, S; Walsh, N; Woods, M; Kazkaz, K

    2011-01-01

    A comprehensive model for explaining scintillation yield in liquid xenon is introduced. We unify various definitions of work function which abound in the literature and incorporate all available data on electron recoil scintillation yield. This results in a better understanding of electron recoil, and facilitates an improved description of nuclear recoil. An incident gamma energy range of O(1 keV) to O(1 MeV) and electric fields between 0 and O(10 kV/cm) are incorporated into this heuristic model. We show results from a Geant4 implementation, but because the model has a few free parameters, implementation in any simulation package should be simple. We use a quasi-empirical approach with an objective of improving detector calibrations and performance verification. The model will aid in the design and optimization of future detectors. This model is also easy to extend to other noble elements. In this paper we lay the foundation for an exhaustive simulation code which we call NEST (Noble Element Simulation Technique).

  3. Listening Comprehension: Approach, Design, Procedure.

    Science.gov (United States)

    Richards, Jack C.

    1983-01-01

    Three dimensions in the teaching of listening comprehension are outlined: (1) a theory is presented that takes account of the cognitive processes used (approach); (2) listeners' needs are analyzed and a taxonomy of microskills and objectives for teaching them are proposed (design); and (3) classroom exercises and activities are suggested…

  4. Comprehensive approach to diabetic nephropathy

    Directory of Open Access Journals (Sweden)

    Bancha Satirapoj

    2014-09-01

    Full Text Available Diabetic nephropathy (DN is a leading cause of mortality and morbidity in patients with diabetes. This complication reflects a complex pathophysiology, whereby various genetic and environmental factors determine susceptibility and progression to end-stage renal disease. DN should be considered in patients with type 1 diabetes for at least 10 years who have microalbuminuria and diabetic retinopathy, as well as in patients with type 1 or type 2 diabetes with macroalbuminuria in whom other causes for proteinuria are absent. DN may also present as a falling estimated glomerular filtration rate with albuminuria as a minor presenting feature, especially in patients taking renin–angiotensin–aldosterone system inhibitors (RAASi. The pathological characteristic features of disease are three major lesions: diffuse mesangial expansion, diffuse thickened glomerular basement membrane, and hyalinosis of arterioles. Functionally, however, the pathophysiology is reflected in dysfunction of the mesangium, the glomerular capillary wall, the tubulointerstitium, and the vasculature. For all diabetic patients, a comprehensive approach to management including glycemic and hypertensive control with RAASi combined with lipid control, dietary salt restriction, lowering of protein intake, increased physical activity, weight reduction, and smoking cessation can reduce the rate of progression of nephropathy and minimize the risk for cardiovascular events. This review focuses on the latest published data dealing with the mechanisms, diagnosis, and current treatment of DN.

  5. A Comparison of Machine Learning Approaches for Corn Yield Estimation

    Science.gov (United States)

    Kim, N.; Lee, Y. W.

    2017-12-01

    Machine learning is an efficient empirical method for classification and prediction, and it is another approach to crop yield estimation. The objective of this study is to estimate corn yield in the Midwestern United States by employing the machine learning approaches such as the support vector machine (SVM), random forest (RF), and deep neural networks (DNN), and to perform the comprehensive comparison for their results. We constructed the database using satellite images from MODIS, the climate data of PRISM climate group, and GLDAS soil moisture data. In addition, to examine the seasonal sensitivities of corn yields, two period groups were set up: May to September (MJJAS) and July and August (JA). In overall, the DNN showed the highest accuracies in term of the correlation coefficient for the two period groups. The differences between our predictions and USDA yield statistics were about 10-11 %.

  6. Building Effective Collaboration in a Comprehensive Approach

    NARCIS (Netherlands)

    Essens, P.J.M.D.; Thompson, M.T.; Karrasch, A.; Jermalavičius, J.

    2016-01-01

    The Comprehensive Approach (CA) to crisis management operations is an essential element in NATO’s transformation in modern operations. At the Bucharest Summit in April 2008, Allied leaders endorsed an Action Plan for the development and implementation of NATO’s contribution to a Comprehensive

  7. The Comprehensive Approach Concept in Multinational Operations

    Directory of Open Access Journals (Sweden)

    Neag Mihai-Marcel

    2017-12-01

    Full Text Available The planning of operations is regulated by documents covering the participation of forces in military actions in a national and multinational context. The process of planning the operations has been adapted to conceptual planning progress. The concept of allied effect-based operations, which was an alternative to old national concepts, has undergone transformations, so the process of planning operations at allied level is currently based on the concept of a comprehensive approach, which is a strategic concept, do not give up effects. The term action-based operations has been replaced by the term “thought-based thinking” and belongs to the general concept of comprehensive approach. If the planning process meant the effects, so the main planning objectives were the effects, then the planning was based on concrete objectives, the effects being maintained for the economy of effort and maximizing efficiency, the main purpose of the effects being the evaluation of the operations. From this point of view, we consider that the concept has not been abandoned, what has changed, it was just the working method, the subject being still topical.

  8. The EU Comprehensive Approach on Somali Piracy

    Directory of Open Access Journals (Sweden)

    Angela Caramerli

    2015-07-01

    Full Text Available The Gulf of Aden represents a strategic issue for the international community, as its geographical position is fundamental as the major trade maritime route. About 50 percent of the world container ships pass through the Gulf of Aden each year, 80 percent of those cargos coming from Europe. For this reason, the piracy issue affecting Somalia is a problem affecting EU member states’ security and economy. This paper is focused on the comprehensive approach acted by the European Union, with a special attention on proposing the implementation of programs against illegal fishing and waste dumping in order to fight Somali piracy. The evaluation of the military mission offers an overview on a solution for the near future, while the training missions and the development funds sustain the build-up of national tools and focus on the solving of the roots of the issue.

  9. Miles-Ezzell's WACC Approach Yields Arbitrage

    OpenAIRE

    Löffler, Andreas

    2002-01-01

    A simple counterexample shows the the widely used WACC approach to value leverage firms developed by Miles and Ezzell can create an arbitrage opportunity. The only consequence to be drawn is that their WACC approach cannot be applied under the circumstances assumed by Miles and Ezzell. We show how the WACC has to be modified in order to obtain proper results. We develop a theory in continuous as well as discrete time. In discrete time it turns out that with a further assumption on the cash fl...

  10. A comprehensive approach to managing hazardous materials

    International Nuclear Information System (INIS)

    Donovan, A.

    1990-01-01

    An increased emphasis on the need for environmental protection indicates that engineers must now consider the disposition of unused hazardous materials as waste. Before specifying and ordering materials, the engineer must consider the impact of the Resource Conservation and Recovery Act (RCRA) and the Occupational Safety and Health Administration's (OSHA's) Hazard Communication Standard. Many commonly used materials such as paint, solvents, glues, and sealants fall under the requirements of these regulations. This paper presents a plant to manage hazardous materials at the US Department of Energy's (DOE's) Waste Isolation Pilot Plant (WIPP), which is managed and operated by Westinghouse Electric Corporation. The basic elements of the plan are training, hazard communication, storage and handling, tracking, and disposal. Steps to be taken to develop the plan are outlined, problems and successes are addressed, and interactions among all affected departments are identified. The benefits of an organized and comprehensive approach to managing hazardous materials are decreased worker injuries, reduction of accidental releases, minimization of waste, and compliance with federal, state, and local safety and environmental laws. In summary, the benefits of an organized program for the management of hazardous materials include compliance with the Environmental Protection Agency's (EPA's) requirements, demonstration of Westinghouse's role as a responsible corporate entity, and reduction of waste management costs

  11. Teaching Listening Comprehension: Bottom-Up Approach

    Science.gov (United States)

    Khuziakhmetov, Anvar N.; Porchesku, Galina V.

    2016-01-01

    Improving listening comprehension skills is one of the urgent contemporary educational problems in the field of second language acquisition. Understanding how L2 listening comprehension works can have a serious influence on language pedagogy. The aim of the paper is to discuss the practical and methodological value of the notion of the perception…

  12. The Comprehensive Approach Initiative: Future Options for NATO

    National Research Council Canada - National Science Library

    Petersen, Friis A; Binnendijk, Hans

    2007-01-01

    ...) should adopt a Comprehensive Approach that would enable the collaborative engagement of all requisite civil and military elements of international power to end hostilities, restore order, commence...

  13. Improving Listening Comprehension through a Whole-Schema Approach.

    Science.gov (United States)

    Ellermeyer, Deborah

    1993-01-01

    Examines the development of the schema, or cognitive structure, theory of reading comprehension. Advances a model for improving listening comprehension within the classroom through a teacher-facilitated approach which leads students to selecting and utilizing existing schema within a whole-language environment. (MDM)

  14. Ethiopian Wheat Yield and Yield Gap Estimation: A Spatial Small Area Integrated Data Approach

    Science.gov (United States)

    Mann, M.; Warner, J.

    2015-12-01

    Despite the collection of routine annual agricultural surveys and significant advances in GIS and remote sensing products, little econometric research has been undertaken in predicting developing nation's agricultural yields. In this paper, we explore the determinants of wheat output per hectare in Ethiopia during the 2011-2013 Meher crop seasons aggregated to the woreda administrative area. Using a panel data approach, combining national agricultural field surveys with relevant GIS and remote sensing products, the model explains nearly 40% of the total variation in wheat output per hectare across the country. The model also identifies specific contributors to wheat yields that include farm management techniques (eg. area planted, improved seed, fertilizer, irrigation), weather (eg. rainfall), water availability (vegetation and moisture deficit indexes) and policy intervention. Our findings suggest that woredas produce between 9.8 and 86.5% of their potential wheat output per hectare given their altitude, weather conditions, terrain, and plant health. At the median, Amhara, Oromiya, SNNP, and Tigray produce 48.6, 51.5, 49.7, and 61.3% of their local attainable yields, respectively. This research has a broad range of applications, especially from a public policy perspective: identifying causes of yield fluctuations, remotely evaluating larger agricultural intervention packages, and analyzing relative yield potential. Overall, the combination of field surveys with spatial data can be used to identify management priorities for improving production at a variety of administrative levels.

  15. Determinants of sovereign debt yield spreads under EMU: Pairwise approach

    NARCIS (Netherlands)

    Fazlioglu, S.

    2013-01-01

    This study aims at providing an empirical analysis of long-term determinants of sovereign debt yield spreads under European EMU (Economic and Monetary Union) through pairwise approach within panel framework. Panel gravity models are increasingly used in the cross-market correlation literature while

  16. A comprehensive approach to reablement in dementia

    NARCIS (Netherlands)

    Poulos, Christopher J; Bayer, Antony; Beaupre, Lauren; Clare, Linda; Poulos, Roslyn G; Wang, Rosalie H; Zuidema, Sytse; McGilton, Katherine S

    As society grapples with an aging population and increasing prevalence of disability, "reablement" as a means of maximizing functional ability in older people is emerging as a potential strategy to help promote independence. Reablement offers an approach to mitigate the impact of dementia on

  17. Perspectives on Counterterrorism: From Stovepipes to a Comprehensive Approach

    Directory of Open Access Journals (Sweden)

    Ronald Crelinsten

    2014-02-01

    Full Text Available This article moves beyond the boundaries that limit counterterrorism discourse and practice to present a more comprehensive approach. In a world where distinctions are blurring between internal and external security, international and domestic jurisdictions, and state and non-state actors, it is important to cast our eyes wide in developing an effective approach to counterterrorism that can apply across a broad variety of policy domains and can outlive the electoral horizon of individual governments. A discussion of five approaches to counterterrorism leads to the identification of thirteen different models which, taken together, can point the way towards a comprehensive approach.

  18. The signal and comprehension approach: decoding and meaning building

    Directory of Open Access Journals (Sweden)

    Rajaa Aquil

    2013-01-01

    Full Text Available This paper discusses Egyptian colloquial Arabic connected speech as a listening problem. The paper proposes a modified approach for teaching listening: The Signal and Comprehension Approach. It is an approach that enhances listening as a skill to attain comprehension in any listening task. The approach focuses on signals laden with linguistic phonological changes that make deciphering connected speech very difficult. By adopting the proposed approach, learners can develop not only their listening skills but also their listening strategies and meaning building. It trains the language learner to crack the code in order to construct meaning. The approach includes pedagogical listening tasks that are based on topdown or world knowledge as well as bottom-up or data driven processes. The discussed tasks use songs as a venue of connected speech. These tasks come from an online course offered through the Georgia Institute of Technology (Georgia Tech that uses songs to teach Arabic language, culture and history.

  19. A Comprehensive Approach to Climate Change: Options and Obstacles

    Energy Technology Data Exchange (ETDEWEB)

    Fuglestvedt, J.S.; Skodvin, T.

    1996-06-01

    The main topics of this report are: (1) key elements in the development of a formula for a comprehensive approach to climate change, (2) relations between gases due to atmospheric chemistry interactions and common emission sources, (3) climate effects of existing international agreements on atmospheric emissions, and (4) methods for comparing gases. Building on the text of the climate convention itself, the authors develop an operational definition of a comprehensive approach and list 13 gases which should be included. There are not many adequate methods of comparing gases with different properties. At present the best choice is the Global Warming Potentials method (GWP), although it leaves the environmentally and politically important issue of the time horizon unresolved. An appendix comments on difficulties of including NOx emitted from surface sources in a comprehensive approach under the FCCC (UN`s Framework Convention on Climate Change). 73 refs., 20 figs., 13 tabs.

  20. Comprehensive Aspectual UML Approach to Support AspectJ

    Directory of Open Access Journals (Sweden)

    Aws Magableh

    2014-01-01

    Full Text Available Unified Modeling Language is the most popular and widely used Object-Oriented modelling language in the IT industry. This study focuses on investigating the ability to expand UML to some extent to model crosscutting concerns (Aspects to support AspectJ. Through a comprehensive literature review, we identify and extensively examine all the available Aspect-Oriented UML modelling approaches and find that the existing Aspect-Oriented Design Modelling approaches using UML cannot be considered to provide a framework for a comprehensive Aspectual UML modelling approach and also that there is a lack of adequate Aspect-Oriented tool support. This study also proposes a set of Aspectual UML semantic rules and attempts to generate AspectJ pseudocode from UML diagrams. The proposed Aspectual UML modelling approach is formally evaluated using a focus group to test six hypotheses regarding performance; a “good design” criteria-based evaluation to assess the quality of the design; and an AspectJ-based evaluation as a reference measurement-based evaluation. The results of the focus group evaluation confirm all the hypotheses put forward regarding the proposed approach. The proposed approach provides a comprehensive set of Aspectual UML structural and behavioral diagrams, which are designed and implemented based on a comprehensive and detailed set of AspectJ programming constructs.

  1. Comprehensive Aspectual UML approach to support AspectJ.

    Science.gov (United States)

    Magableh, Aws; Shukur, Zarina; Ali, Noorazean Mohd

    2014-01-01

    Unified Modeling Language is the most popular and widely used Object-Oriented modelling language in the IT industry. This study focuses on investigating the ability to expand UML to some extent to model crosscutting concerns (Aspects) to support AspectJ. Through a comprehensive literature review, we identify and extensively examine all the available Aspect-Oriented UML modelling approaches and find that the existing Aspect-Oriented Design Modelling approaches using UML cannot be considered to provide a framework for a comprehensive Aspectual UML modelling approach and also that there is a lack of adequate Aspect-Oriented tool support. This study also proposes a set of Aspectual UML semantic rules and attempts to generate AspectJ pseudocode from UML diagrams. The proposed Aspectual UML modelling approach is formally evaluated using a focus group to test six hypotheses regarding performance; a "good design" criteria-based evaluation to assess the quality of the design; and an AspectJ-based evaluation as a reference measurement-based evaluation. The results of the focus group evaluation confirm all the hypotheses put forward regarding the proposed approach. The proposed approach provides a comprehensive set of Aspectual UML structural and behavioral diagrams, which are designed and implemented based on a comprehensive and detailed set of AspectJ programming constructs.

  2. A Comprehensive Approach for Pectin Chemical and Functional Characterization

    DEFF Research Database (Denmark)

    de Sousa, António Felipe Gomes Teixeira

    In this work, a comprehensive approach for the chemical and functional analysis of pectin was used in order to relate the different extraction conditions used to the polymer structure and the final functional (mainly gelling) properties. A wide range of methods were utilized including chemical an...

  3. Comprehensive Analysis Competence and Innovative Approaches for Sustainable Chemical Production.

    Science.gov (United States)

    Appel, Joerg; Colombo, Corrado; Dätwyler, Urs; Chen, Yun; Kerimoglu, Nimet

    2016-01-01

    Humanity currently sees itself facing enormous economic, ecological, and social challenges. Sustainable products and production in specialty chemistry are an important strategic element to address these megatrends. In addition to that, digitalization and global connectivity will create new opportunities for the industry. One aspect is examined in this paper, which shows the development of comprehensive analysis of production networks for a more sustainable production in which the need for innovative solutions arises. Examples from data analysis, advanced process control and automated performance monitoring are shown. These efforts have significant impact on improved yields, reduced energy and water consumption, and better product performance in the application of the products.

  4. Yielding physically-interpretable emulators - A Sparse PCA approach

    Science.gov (United States)

    Galelli, S.; Alsahaf, A.; Giuliani, M.; Castelletti, A.

    2015-12-01

    Projection-based techniques, such as Principal Orthogonal Decomposition (POD), are a common approach to surrogate high-fidelity process-based models by lower order dynamic emulators. With POD, the dimensionality reduction is achieved by using observations, or 'snapshots' - generated with the high-fidelity model -, to project the entire set of input and state variables of this model onto a smaller set of basis functions that account for most of the variability in the data. While reduction efficiency and variance control of POD techniques are usually very high, the resulting emulators are structurally highly complex and can hardly be given a physically meaningful interpretation as each basis is a projection of the entire set of inputs and states. In this work, we propose a novel approach based on Sparse Principal Component Analysis (SPCA) that combines the several assets of POD methods with the potential for ex-post interpretation of the emulator structure. SPCA reduces the number of non-zero coefficients in the basis functions by identifying a sparse matrix of coefficients. While the resulting set of basis functions may retain less variance of the snapshots, the presence of a few non-zero coefficients assists in the interpretation of the underlying physical processes. The SPCA approach is tested on the reduction of a 1D hydro-ecological model (DYRESM-CAEDYM) used to describe the main ecological and hydrodynamic processes in Tono Dam, Japan. An experimental comparison against a standard POD approach shows that SPCA achieves the same accuracy in emulating a given output variable - for the same level of dimensionality reduction - while yielding better insights of the main process dynamics.

  5. Comprehensive change management concepts. Development of a participatory approach.

    Science.gov (United States)

    Zink, Klaus J; Steimle, Ulrich; Schröder, Delia

    2008-07-01

    During the last years, many change projects in organizations did not have the planned success. Therefore at first, the causes for these failures and the success factors contributing to organizational change have to be discussed. To get better results, a comprehensive change management concept has been developed and tested in an ongoing research project. By using concepts for an integrated assessment and design of organizations, an approach for analyzing the current situation has been elaborated to identify "lack of integration" in the change initiatives of a company. To realize an integrated overall approach of modernization by harmonizing different methods and concepts, first, one has to prove their relationship to policy and strategy (vertical harmonization). The second step is to take into account the fact that there has to be a logical fit between the single concepts (horizontal harmonization). But even if all elements are logically coherent, that does not mean that the people working in the company also see this coherence. Therefore, in addition to the "logical fit", one has to examine the "psychological fit". In the end, a concept for analyzing the status quo in an organization as a result of "objective data" and "subjective data" originated. Subsequently, instruments for harmonizing different modernizing concepts have been applied. As part of the comprehensive change management concept participatory ergonomic approaches have been used during the project. The present study shows this approach in the case of one company.

  6. A New Comprehensive Approach for Predicting Injectivity Decline during Waterflooding

    DEFF Research Database (Denmark)

    Yuan, Hao; Nielsen, Sidsel Marie; Shapiro, Alexander

    Injectivity decline during sea waterflooding or produced water re-injection is widely observed in North Sea, Gulf of Mexico and Campos Basin fields. The formation damage occurs mainly due to the deposition of suspended solids around injectors and the build-up the external filter cakes in the well...... bores. The ability to predict injectivity decline accurately is of great importance for project designs and water management. A comprehensive model that incorporates a variety of factors influencing the process is desirable for the prediction. In this paper, a new comprehensive approach for predicting...... injectivity decline during water flooding is proposed. The deep bed filtration is described by novel stochastic random walk equations. The injectivity decline model takes into account the reservoir heterogeneity and the distribution of solid particles by sizes. It also accounts for the later formation...

  7. Photonomics: automation approaches yield economic aikido for photonics device manufacture

    Science.gov (United States)

    Jordan, Scott

    2002-09-01

    In the glory days of photonics, with exponentiating demand for photonics devices came exponentiating competition, with new ventures commencing deliveries seemingly weekly. Suddenly the industry was faced with a commodity marketplace well before a commodity cost structure was in place. Economic issues like cost, scalability, yield-call it all "Photonomics" -now drive the industry. Automation and throughput-optimization are obvious answers, but until now, suitable modular tools had not been introduced. Available solutions were barely compatible with typical transverse alignment tolerances and could not automate angular alignments of collimated devices and arrays. And settling physics served as the insoluble bottleneck to throughput and resolution advancement in packaging, characterization and fabrication processes. The industry has addressed these needs in several ways, ranging from special configurations of catalog motion devices to integrated microrobots based on a novel mini-hexapod configuration. This intriguing approach allows tip/tilt alignments to be automated about any point in space, such as a beam waist, a focal point, the cleaved face of a fiber, or the optical axis of a waveguide- ideal for MEMS packaging automation and array alignment. Meanwhile, patented new low-cost settling-enhancement technology has been applied in applications ranging from air-bearing long-travel stages to subnanometer-resolution piezo positioners to advance resolution and process cycle-times in sensitive applications such as optical coupling characterization and fiber Bragg grating generation. Background, examples and metrics are discussed, providing an up-to-date industry overview of available solutions.

  8. A crop model-based approach for sunflower yields

    Directory of Open Access Journals (Sweden)

    João Guilherme Dal Belo Leite

    2014-10-01

    Full Text Available Pushed by the Brazilian biodiesel policy, sunflower (Helianthus annuus L. production is becoming increasingly regarded as an option to boost farmers' income, particularly under semi-arid conditions. Biodiesel related opportunities increase the demand for decision-making information at different levels, which could be met by simulation models. This study aimed to evaluate the performance of the crop model OILCROP-SUN to simulate sunflower development and growth under Brazilian conditions and to explore sunflower water- and nitrogen-limited, water-limited and potential yield and yield variability over an array of sowing dates in the northern region of the state of Minas Gerais, Brazil. For model calibration, an experiment was conducted in which two sunflower genotypes (H358 and E122 were cultivated in a clayey soil. Growth components (leaf area index, above ground biomass, grain yield and development stages (crop phenology were measured. A database composed of 27 sunflower experiments from five Brazilian regions was used for model evaluation. The spatial yield distribution of sunflower was mapped using ordinary kriging in ArcGIS. The model simulated sunflower grain productivity satisfactorily (Root Mean Square Error ≈ 13 %. Simulated yields were relatively high (1,750 to 4,250 kg ha-1 and the sowing window was fairly wide (Oct to Feb for northwestern locations, where sunflower could be cultivated as a second crop (double cropping at the end of the rainy season. The hybrid H358 had higher yields for all simulated sowing dates, growth conditions and selected locations.

  9. Racial Differences by Ischemic Stroke Subtype: A Comprehensive Diagnostic Approach

    Directory of Open Access Journals (Sweden)

    Sarah Song

    2012-01-01

    Full Text Available Background. Previous studies have suggested that black populations have more small-vessel and fewer cardioembolic strokes. We sought to analyze racial differences in ischemic stroke subtype employing a comprehensive diagnostic workup with magnetic resonance-imaging-(MRI- based evaluation including diffusion-weighted imaging (DWI. Methods. 350 acute ischemic stroke patients admitted to an urban hospital with standardized comprehensive diagnostic evaluations were retrospectively analyzed. Ischemic stroke subtype was determined by three Trial of Org 10172 in Acute Stroke Treatment (TOAST classification systems. Results. We found similar proportions of cardioembolic and lacunar strokes in the black and white cohort. The only subtype category with a significant difference by race was “stroke of other etiology,” more common in whites. Black stroke patients were more likely to have an incomplete evaluation, but this did not reach significance. Conclusions. We found similar proportions by race of cardioembolic and lacunar strokes when employing a full diagnostic evaluation including DWI MRI. The relatively high rate of cardioembolism may have been underappreciated in black stroke patients when employing a CT approach to stroke subtype diagnosis. Further research is required to better understand the racial differences in frequency of “stroke of other etiology” and explore disparities in the extent of diagnostic evaluations.

  10. A comprehensive dynamic modeling approach for giant magnetostrictive material actuators

    International Nuclear Information System (INIS)

    Gu, Guo-Ying; Zhu, Li-Min; Li, Zhi; Su, Chun-Yi

    2013-01-01

    In this paper, a comprehensive modeling approach for a giant magnetostrictive material actuator (GMMA) is proposed based on the description of nonlinear electromagnetic behavior, the magnetostrictive effect and frequency response of the mechanical dynamics. It maps the relationships between current and magnetic flux at the electromagnetic part to force and displacement at the mechanical part in a lumped parameter form. Towards this modeling approach, the nonlinear hysteresis effect of the GMMA appearing only in the electrical part is separated from the linear dynamic plant in the mechanical part. Thus, a two-module dynamic model is developed to completely characterize the hysteresis nonlinearity and the dynamic behaviors of the GMMA. The first module is a static hysteresis model to describe the hysteresis nonlinearity, and the cascaded second module is a linear dynamic plant to represent the dynamic behavior. To validate the proposed dynamic model, an experimental platform is established. Then, the linear dynamic part and the nonlinear hysteresis part of the proposed model are identified in sequence. For the linear part, an approach based on axiomatic design theory is adopted. For the nonlinear part, a Prandtl–Ishlinskii model is introduced to describe the hysteresis nonlinearity and a constrained quadratic optimization method is utilized to identify its coefficients. Finally, experimental tests are conducted to demonstrate the effectiveness of the proposed dynamic model and the corresponding identification method. (paper)

  11. Comprehensive Measurement of Neutron Yield Produced by 62 MeV Protons on Beryllium Target

    International Nuclear Information System (INIS)

    Osipenko, M.; Ripani, M.; Ricco, G.; Alba, R.; Schillaci, M.; Cosentino, L.; Del Zoppo, A.; Di Pietro, A.; Figuera, P.; Finocchiaro, P.; Maiolino, C.; Santonocito, D.; Scuderi, V.; Barbagallo, M.; Colonna, N.; Boccaccio, P.; Esposito, J.; Celentano, A.; Viberti, C.M.; Kostyukov, A.

    2013-06-01

    A low-power prototype of neutron amplifier, based on a 70 MeV, high current proton cyclotron being installed at LNL for the SPES RIB facility, was recently proposed within INFN-E project. This prototype uses a thick Beryllium converter to produce a fast neutron spectrum feeding a sub-critical reactor core. To complete the design of such facility the new measurement of neutron yield from a thick Beryllium target was performed at LNS. This measurement used liquid scintillator detectors to identify produced neutrons by Pulse Shape Discrimination and Time of Flight technique to measure neutron energy in the range 0.5-62 MeV. To extend the covered neutron energy range 3 He detector was used to measure neutrons below 0.5 MeV. The obtained yields were normalized to the charge deposited by the proton beam on the metallic Beryllium target. These techniques allowed to achieve a wide angular coverage from 0 to 150 degrees and to explore almost complete neutron energy interval. (authors)

  12. A comprehensive approach to quality management of intensive care services.

    Science.gov (United States)

    Hariharan, Seetharaman; Dey, Prasanta Kumar

    2010-01-01

    The purpose of this paper is to develop a comprehensive framework for improving intensive care unit performance. The study introduces a quality management framework by combining cause and effect diagram and logical framework. An intensive care unit was identified for the study on the basis of its performance. The reasons for not achieving the desired performance were identified using a cause and effect diagram with the stakeholder involvement. A logical framework was developed using information from the cause and effect diagram and a detailed project plan was developed. The improvement projects were implemented and evaluated. Stakeholders identified various intensive care unit issues. Managerial performance, organizational processes and insufficient staff were considered major issues. A logical framework was developed to plan an improvement project to resolve issues raised by clinicians and patients. Improved infrastructure, state-of-the-art equipment, well maintained facilities, IT-based communication, motivated doctors, nurses and support staff, improved patient care and improved drug availability were considered the main project outputs for improving performance. The proposed framework is currently being used as a continuous quality improvement tool, providing a planning, implementing, monitoring and evaluating framework for the quality improvement measures on a sustainable basis. The combined cause and effect diagram and logical framework analysis is a novel and effective approach to improving intensive care performance. Similar approaches could be adopted in any intensive care unit. The paper focuses on a uniform model that can be applied to most intensive care units.

  13. A comprehensive approach to age-dependent dosimetric modeling

    International Nuclear Information System (INIS)

    Leggett, R.W.; Cristy, M.; Eckerman, K.F.

    1986-01-01

    In the absence of age-specific biokinetic models, current retention models of the International Commission on Radiological Protection (ICRP) frequently are used as a point of departure for evaluation of exposures to the general population. These models were designed and intended for estimation of long-term integrated doses to the adult worker. Their format and empirical basis preclude incorporation of much valuable physiological information and physiologically reasonable assumptions that could be used in characterizing the age-specific behavior of radioelements in humans. In this paper we discuss a comprehensive approach to age-dependent dosimetric modeling in which consideration is given not only to changes with age in masses and relative geometries of body organs and tissues but also to best available physiological and radiobiological information relating to the age-specific biobehavior of radionuclides. This approach is useful in obtaining more accurate estimates of long-term dose commitments as a function of age at intake, but it may be particularly valuable in establishing more accurate estimates of dose rate as a function of age. Age-specific dose rates are needed for a proper analysis of the potential effects on estimates or risk of elevated dose rates per unit intake in certain stages of life, elevated response per unit dose received during some stages of life, and age-specific non-radiogenic competing risks

  14. A comprehensive approach to age-dependent dosimetric modeling

    International Nuclear Information System (INIS)

    Leggett, R.W.; Cristy, M.; Eckerman, K.F.

    1987-01-01

    In the absence of age-specific biokinetic models, current retention models of the International Commission of Radiological Protection (ICRP) frequently are used as a point of departure for evaluation of exposures to the general population. These models were designed and intended for estimation of long-term integrated doses to the adult worker. Their format and empirical basis preclude incorporation of much valuable physiological information and physiologically reasonable assumptions that could be used in characterizing the age-specific behavior of radioelements in humans. In this paper a comprehensive approach to age-dependent dosimetric modeling is discussed in which consideration is given not only to changes with age in masses and relative geometries of body organs and tissues but also to best available physiological and radiobiological information relating to the age-specific biobehavior of radionuclides. This approach is useful in obtaining more accurate estimates of long-term dose commitments as a function of age at intake, but it may be particularly valuable in establishing more accurate estimates of dose rate as a function of age. Age-specific dose rates are needed for a proper analysis of the potential effects on estimates of risk of elevated dose rates per unit intake in certain stages of life, elevated response per unit dose received during some stages of life, and age-specific non-radiogenic competing risks. 16 refs.; 3 figs.; 1 table

  15. Comprehensive molecular sampling yields a robust phylogeny for geometrid moths (Lepidoptera: Geometridae.

    Directory of Open Access Journals (Sweden)

    Pasi Sihvonen

    Full Text Available BACKGROUND: The moth family Geometridae (inchworms or loopers, with approximately 23,000 described species, is the second most diverse family of the Lepidoptera. Apart from a few recent attempts based on morphology and molecular studies, the phylogeny of these moths has remained largely uninvestigated. METHODOLOGY/PRINCIPAL FINDINGS: We performed a rigorous and extensive molecular analysis of eight genes to examine the geometrid affinities in a global context, including a search for its potential sister-taxa. Our maximum likelihood analyses included 164 taxa distributed worldwide, of which 150 belong to the Geometridae. The selected taxa represent all previously recognized subfamilies and nearly 90% of recognized tribes, and originate from all over world. We found the Geometridae to be monophyletic with the Sematuridae+Epicopeiidae clade potentially being its sister-taxon. We found all previously recognized subfamilies to be monophyletic, with a few taxa misplaced, except the Oenochrominae+Desmobathrinae complex that is a polyphyletic assemblage of taxa and the Orthostixinae, which was positioned within the Ennominae. The Sterrhinae and Larentiinae were found to be sister to the remaining taxa, followed by Archiearinae, the polyphyletic assemblage of Oenochrominae+Desmobathrinae moths, Geometrinae and Ennominae. CONCLUSIONS/SIGNIFICANCE: Our study provides the first comprehensive phylogeny of the Geometridae in a global context. Our results generally agree with the other, more restricted studies, suggesting that the general phylogenetic patterns of the Geometridae are now well-established. Generally the subfamilies, many tribes, and assemblages of tribes were well supported but their interrelationships were often weakly supported by our data. The Eumeleini were particularly difficult to place in the current system, and several tribes were found to be para- or polyphyletic.

  16. Comprehensive Case Analysis on Participatory Approaches, from Nexus Perspectives

    Science.gov (United States)

    Masuhara, N.; Baba, K.

    2014-12-01

    According to Messages from the Bonn2011 Conference, involving local communities fully and effectively in the planning and implementation processes related to water, energy and food nexus for local ownership and commitment should be strongly needed. The participatory approaches such as deliberative polling, "joint fact-finding" and so on have been applied so far to resolve various environmental disputes, however the drivers and barriers in such processes have not been necessarily enough analyzed in a comprehensive manner, especially in Japan. Our research aims to explore solutions for conflicts in the context of water-energy-food nexus in local communities. To achieve it, we clarify drivers and barriers of each approaches applied so far in water, energy and food policy, focusing on how to deal with scientific facts. We generate hypotheses primarily that multi-issue solutions through policy integration will be more effective for conflicts in the context of water-energy-food nexus than single issue solutions for each policy. One of the key factors to formulate effective solutions is to integrate "scientific fact (expert knowledge)" and "local knowledge". Given this primary hypothesis, more specifically, we assume that it is effective for building consensus to provide opportunities to resolve the disagreement of "framing" that stakeholders can offer experts the points for providing scientific facts and that experts can get common understanding of scientific facts in the early stage of the process. To verify the hypotheses, we develop a database of the cases which such participatory approaches have been applied so far to resolve various environmental disputes based on literature survey of journal articles and public documents of Japanese cases. At present, our database is constructing. But it's estimated that conditions of framing and providing scientific information are important driving factors for problem solving and consensus building. And it's important to refine

  17. Individual differences in reading comprehension : A componential approach to eighth graders’ expository text comprehension

    NARCIS (Netherlands)

    Welie, C.J.M.

    2017-01-01

    Why do secondary school students differ in their text comprehension? This is an important question because many secondary school students are unable to achieve the level of text comprehension required to enable learning from their school book texts. This thesis contributes to answering this question

  18. Comprehensive benchmarking and ensemble approaches for metagenomic classifiers.

    Science.gov (United States)

    McIntyre, Alexa B R; Ounit, Rachid; Afshinnekoo, Ebrahim; Prill, Robert J; Hénaff, Elizabeth; Alexander, Noah; Minot, Samuel S; Danko, David; Foox, Jonathan; Ahsanuddin, Sofia; Tighe, Scott; Hasan, Nur A; Subramanian, Poorani; Moffat, Kelly; Levy, Shawn; Lonardi, Stefano; Greenfield, Nick; Colwell, Rita R; Rosen, Gail L; Mason, Christopher E

    2017-09-21

    One of the main challenges in metagenomics is the identification of microorganisms in clinical and environmental samples. While an extensive and heterogeneous set of computational tools is available to classify microorganisms using whole-genome shotgun sequencing data, comprehensive comparisons of these methods are limited. In this study, we use the largest-to-date set of laboratory-generated and simulated controls across 846 species to evaluate the performance of 11 metagenomic classifiers. Tools were characterized on the basis of their ability to identify taxa at the genus, species, and strain levels, quantify relative abundances of taxa, and classify individual reads to the species level. Strikingly, the number of species identified by the 11 tools can differ by over three orders of magnitude on the same datasets. Various strategies can ameliorate taxonomic misclassification, including abundance filtering, ensemble approaches, and tool intersection. Nevertheless, these strategies were often insufficient to completely eliminate false positives from environmental samples, which are especially important where they concern medically relevant species. Overall, pairing tools with different classification strategies (k-mer, alignment, marker) can combine their respective advantages. This study provides positive and negative controls, titrated standards, and a guide for selecting tools for metagenomic analyses by comparing ranges of precision, accuracy, and recall. We show that proper experimental design and analysis parameters can reduce false positives, provide greater resolution of species in complex metagenomic samples, and improve the interpretation of results.

  19. Pediatric Multiple Sclerosis: Genes, Environment, and a Comprehensive Therapeutic Approach.

    Science.gov (United States)

    Cappa, Ryan; Theroux, Liana; Brenton, J Nicholas

    2017-10-01

    Pediatric multiple sclerosis is an increasingly recognized and studied disorder that accounts for 3% to 10% of all patients with multiple sclerosis. The risk for pediatric multiple sclerosis is thought to reflect a complex interplay between environmental and genetic risk factors. Environmental exposures, including sunlight (ultraviolet radiation, vitamin D levels), infections (Epstein-Barr virus), passive smoking, and obesity, have been identified as potential risk factors in youth. Genetic predisposition contributes to the risk of multiple sclerosis, and the major histocompatibility complex on chromosome 6 makes the single largest contribution to susceptibility to multiple sclerosis. With the use of large-scale genome-wide association studies, other non-major histocompatibility complex alleles have been identified as independent risk factors for the disease. The bridge between environment and genes likely lies in the study of epigenetic processes, which are environmentally-influenced mechanisms through which gene expression may be modified. This article will review these topics to provide a framework for discussion of a comprehensive approach to counseling and ultimately treating the pediatric patient with multiple sclerosis. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. Diagnostic yield of the comprehensive assessment of developmental delay/mental retardation in an institute of child neuropsychiatry.

    Science.gov (United States)

    Battaglia, A; Bianchini, E; Carey, J C

    1999-01-01

    , while confirming the diagnostic utility of cytogenetic/molecular genetic, and neuroimaging studies, suggest the usefulness of accurate electroencephalogram recordings, and stress the importance of a thorough physical examination. Referral to a university child neurology and psychiatry service, where a comprehensive assessment with a selected battery of investigations is possible, yields etiologic findings in a high percentage of DD/MR patients, with important implications for management, prognosis and recurrence risk estimate.

  1. Taking a Comprehensive Approach to Common Core Rollout

    Science.gov (United States)

    Illingworth, Amy

    2016-01-01

    One district, South Bay Union School District, devises and executes a comprehensive strategy that includes training for district staff, teachers and coaches, including using PLCs and professional development in the implementation of Common Core English language arts standards.

  2. An alternative approach for modeling strength differential effect in sheet metals with symmetric yield functions

    Science.gov (United States)

    Kurukuri, Srihari; Worswick, Michael J.

    2013-12-01

    An alternative approach is proposed to utilize symmetric yield functions for modeling the tension-compression asymmetry commonly observed in hcp materials. In this work, the strength differential (SD) effect is modeled by choosing separate symmetric plane stress yield functions (for example, Barlat Yld 2000-2d) for the tension i.e., in the first quadrant of principal stress space, and compression i.e., third quadrant of principal stress space. In the second and fourth quadrants, the yield locus is constructed by adopting interpolating functions between uniaxial tensile and compressive stress states. In this work, different interpolating functions are chosen and the predictive capability of each approach is discussed. The main advantage of this proposed approach is that the yield locus parameters are deterministic and relatively easy to identify when compared to the Cazacu family of yield functions commonly used for modeling SD effect observed in hcp materials.

  3. Forest Fire Management: A Comprehensive And Operational Approach

    Science.gov (United States)

    Fabrizi, Roberto; Perez, Bruno; Gomez, Antonio

    2013-12-01

    Remote sensing plays an important role in obtaining rapid and complete information on the occurrence and evolution in space and time of forest fires. In this paper, we present a comprehensive study of fire events through Earth Observation data for early warning, crisis monitoring and post-event damage assessment or a synthesis of the fire event, both in a wide spatial range (local to regional) and temporal scale (short to long term). The fire products are stored and distributed by means of a WebGIS and a Geoportal with additional auxiliary geospatial data. These products allow fire managers to perform analysis and decision making in a more comprehensive manner.

  4. Europeanisation and the EU's comprehensive approach to crisis management in Africa

    DEFF Research Database (Denmark)

    Olsen, Gorm Rye; Furness, Mark

    2016-01-01

    This article asks to what extent the European Union (EU) and its member states actually pursued and implemented comprehensive approaches in relation to crisis management in Africa. It also asks what can explain the lack of full implementation of the comprehensive approach in the cases of South...... may follow policy declarations more closely. The comprehensive approach nevertheless indicates an emerging Europeanisation norm influencing policy approaches to the sensitive nexuses that link security, development and crisis response. Evidence from country-level interventions reveals that this norm...

  5. Comprehensive Approach to Heart Failure: an Urgent Need

    Directory of Open Access Journals (Sweden)

    Yanier Coll Muñoz

    2015-11-01

    Full Text Available Heart failure leads to the activation of a neurohormonal response that interacts with the hemodynamic changes, which are joined by functional and structural myocardial abnormalities, that may exist. This paper addresses the role of the renin-angiotensin system in the pathophysiology of heart failure and the use of non-invasive complementary methods that provide additional information necessary for the assessment and comprehensive management of patients, without losing the essential connection between the doctor and the patient.

  6. Sustainable Technology and Business Innovation Framework – A Comprehensive Approach

    Directory of Open Access Journals (Sweden)

    Maja Levi Jakšić

    2018-05-01

    Full Text Available Despite of the rising awareness of the urgency in finding more efficient and effective ways to achieve sustainable development, comprehensive and consistent meaning is still elusive both in theory and practice. The aim of this paper is to create a more structured theoretical framework related to macro and micro perspectives of sustainable development, relevant also to enhancing sustainable practices. We here propose a comprehensive framework model for structuring multiple sustainability principles and practices, detected in the literature as different sustainability categories related to both macro and micro perspectives of sustainability in the economy and society. The focus is on relevant sustainability principles of technology and business innovation in relation to basic technology and business innovation models as a contribution to less investigated theoretical aspects of sustainable business development. We developed a set of related matrices indicating the relevant roles and relationships between these principles in achieving sustainable business goals related to sustainable economy dimensions. Finally, the paper shows that the proposed Related Matrices Framework fulfils the main objective set in the initial research stages, i.e. to be of both theoretical and practical relevance. As a contribution to the theory it meets the need of building a structured, integrated, comprehensive model that serves the needs of better understanding different sustainability of macro and micro categories, indicating mutual relations and influences. In a practical sense, it can be used as a tool to support the management of change in companies oriented at achieving sustainable business goals based on sustainable technology and business innovation.

  7. [The comprehensive approach to the rehabilitative treatment of junior athletes].

    Science.gov (United States)

    Stepanenko, N P; Levitskaya, T E; Tsekhmeistruk, E A; Tren'kaeva, N A; Tyulyupo, S V; Dostovalova, O V; Kremeno, S V; Shakhova, S S; Chekcheeva, V D

    The objective of the present study was the development of the comprehensive program for the medico-psychological follow-up of the male and female junior athletes (rhythmic gymnastics) with the purpose of stabilizing their hormonal and emotional status, as well as improving sport performances based on the use of modern hardware-software technologies. The comprehensive examination of 72 female athletes at the mean age of 11.5±0.6 years attending R. Kuznetsov specialized school of rhythmic gymnastics of the Olympic reserve in the city of Seversk has been undertaken on the basis of Tomsk Research Institute of Balneology and Physiotherapy, the branch of Siberian Federal Research and Clinical Centre. The program of comprehensive medical psychological rehabilitation for the junior athletes of either sex engaged in sportive activities requiring precise technical actions has been elaborated. The method of the combined therapeutic treatment included physical exercises therapy, manual massage, dry carbonic bathtubs, psychological activities with the application of biological feedback trainings and cognitive trainings; it was intended for the correction of the hormonal status and the improvement of the psycho-emotional conditions of the athletes. The combined treatment based on the use of the modern hardware-software technologies was shown to promote the restoration and development of the psychophysical and psychological qualities of the male and female junior athletes indispensable for the maintenance of their high readiness for the efficient sports activities at the subsequent stages of the training cycle. In addition, such treatment enhances the adaptation resources of the athletes.

  8. Sentence comprehension in aphasia: A noisy channel approach

    Directory of Open Access Journals (Sweden)

    Michael Walsh Dickey

    2014-04-01

    Full Text Available Probabilistic accounts of language understanding assume that comprehension involves determining the probability of an intended message (m given an input utterance (u (P(m|u; e.g. Gibson et al, 2013a; Levy et al, 2009. One challenge is that communication occurs within a noisy channel; i.e. the comprehender’s representation of u may have been distorted, e.g., by a typo or by impairment associated with aphasia. Bayes’ rule provides a model of how comprehenders can combine the prior probability of m (P(m with the probability that m would have been distorted to u (P(mu to calculate the probability of m given u (P(m|u  P(mP(mu. This formalism can capture the observation that people with aphasia (PWA rely more on semantics than syntax during comprehension (e.g., Caramazza & Zurif, 1976: given the high probability that their representation of the input is unreliable, they weigh message likelihood more heavily. Gibson et al. (2013a showed that unimpaired adults are sensitive to P(m and P(mu: they more often chose interpretations that increased message plausibility or involved distortions requiring fewer changes, and/or deletions instead of insertions (see Figure 1a for examples. Gibson et al. (2013b found PWA were also sensitive to both P(m and P(mu in an act-out task, but relied more heavily than unimpaired controls on P(m. This shows group-level optimization towards the less noisy (semantic channel in PWA. The current experiment (8 PWA; 7 age-matched controls investigated noisy channel optimization at the level of individual PWA. It also included active/passive items with a weaker plausibility manipulation to test whether P(m is higher for implausible than impossible strings. The task was forced-choice sentence-picture matching (Figure 1b. Experimental sentences crossed active versus passive (A-P structures with plausibility (Set 1 or impossibility (Set 2, and prepositional-object versus double-object structures (PO-DO: Set 3 with

  9. [A comprehensive assessment of ATMP. Difficulties and approaches].

    Science.gov (United States)

    Thanner, M; Nagel, E

    2011-07-01

    Advanced therapy medicinal products (ATMP) are associated with high expectations because they offer new opportunities for the treatment of diseases, e.g., the possibility of regenerating damaged or lost tissue. What the products (gene therapy, somatic cell therapy, and tissue engineered products) have in common is an innovative and complex development process that combines science and engineering. At the same time, this field of research is becoming increasingly interdisciplinary and requires international cooperation. A comprehensive assessment of ATMP has to take these issues into account. The application of Beauchamp and Childress' Four Principles (Principle-Based Ethics) as well as Discourse Ethics as a framework may lead to a broader consideration of medical ethics issues.

  10. Empirical Approaches to Measuring the Intelligibility of Different Varieties of English in Predicting Listener Comprehension

    Science.gov (United States)

    Kang, Okim; Thomson, Ron I.; Moran, Meghan

    2018-01-01

    This study compared five research-based intelligibility measures as they were applied to six varieties of English. The objective was to determine which approach to measuring intelligibility would be most reliable for predicting listener comprehension, as measured through a listening comprehension test similar to the Test of English as a Foreign…

  11. Predicting Text Comprehension, Processing, and Familiarity in Adult Readers: New Approaches to Readability Formulas

    Science.gov (United States)

    Crossley, Scott A.; Skalicky, Stephen; Dascalu, Mihai; McNamara, Danielle S.; Kyle, Kristopher

    2017-01-01

    Research has identified a number of linguistic features that influence the reading comprehension of young readers; yet, less is known about whether and how these findings extend to adult readers. This study examines text comprehension, processing, and familiarity judgment provided by adult readers using a number of different approaches (i.e.,…

  12. A Comprehensive Approach to Adaptive Processing Both on Transmit and Receive Including Presence of Waveform Diversity

    National Research Council Canada - National Science Library

    Sarkar, Tapan

    2006-01-01

    .... Use of waveform diversity and a comprehensive approach to adaptive processing may not be useful if the sensors deviate from their true positions, due to environmental effects or due to mechanical...

  13. [A comprehensive approach to designing of magnetotherapy techniques based on the Atos device].

    Science.gov (United States)

    Raĭgorodskiĭ, Iu M; Semiachkin, G P; Tatarenko, D A

    1995-01-01

    The paper determines how to apply a comprehensive approach to designing magnetic therapeutical techniques based on concomitant exposures to two or more physical factors. It shows the advantages of the running pattern of a magnetic field and photostimuli in terms of optimization of physiotherapeutical exposures. An Atos apparatus with an Amblio-1 attachment is used as an example to demonstrate how to apply the comprehensive approach for ophthalmology.

  14. Comprehensive Care

    Science.gov (United States)

    ... Comprehensive Care Share this page Facebook Twitter Email Comprehensive Care Understand the importance of comprehensive MS care ... In this article A complex disease requires a comprehensive approach Today multiple sclerosis (MS) is not a ...

  15. Facial sculpting: Comprehensive approach for aesthetic correction of round face

    Directory of Open Access Journals (Sweden)

    M K Thomas

    2012-01-01

    Full Text Available Context: Standards for an aesthetic face are dynamic. The current trend is towards a leaner looking face with preservation of the inverted triangle of youth. Procedures that have been reported to be employed for correction of a chubby face include buccal fat pad excision, facial liposuction and injection lipolysis. In addition to giving the face an aesthetic triangular cut, chin and malar augmentation may be performed. The rounded appearance at the angles may further be reduced by injection of Botulinum toxin into the masseter. Materials and Methods: Forty patients who presented to us for correction of chubby (round faces were analysed and treated by facial sculpting surgery, which included at least two of the procedures in combination. The procedures included facial liposuction, buccal fat pad excision, chin augmentation, malar augmentation and injection lipolysis. All cases were followed-up for a minimum of 6 months after surgery. Results: Aesthetic expectations of the patients were met in 39 cases, one patient complained of facial asymmetry following facial liposuction and was subjected to a touch-up injection lipolysis. Conclusions: A combination of procedures is necessary to give the face an attractive contour. All the individual procedures have stood the test of time and are safe, proven and are put in mainstream. However, a thorough analysis of the face preoperatively and then subjecting the patient to a combination of these procedures in a single surgical sitting has yielded good results as seen in this study.

  16. β-Thalassemia intermedia: a comprehensive overview and novel approaches.

    Science.gov (United States)

    Asadov, Chingiz; Alimirzoeva, Zohra; Mammadova, Tahira; Aliyeva, Gunay; Gafarova, Shahla; Mammadov, Jeyhun

    2018-01-29

    β-Thalassemia intermedia is a clinical condition of intermediate gravity between β-thalassemia minor, the asymptomatic carrier, and β-thalassemia major, the transfusion-dependent severe anemia. It is characterized by a significant clinical polymorphism, which is attributable to its genetic heterogeneity. Ineffective erythropoiesis, chronic anemia, and iron overload contribute to the clinical complications of thalassemia intermedia through stepwise pathophysiological mechanisms. These complications, including splenomegaly, extramedullary erythropoiesis, iron accumulation, leg ulcers, thrombophilia, and bone abnormalities can be managed via fetal hemoglobin induction, occasional transfusions, chelation, and in some cases, stem cell transplantation. Given its clinical diversity, thalassemia intermedia patients require tailored approaches to therapy. Here we present an overview and novel approaches to the genetic basis, pathophysiological mechanisms, clinical complications, and optimal management of thalassemia intermedia.

  17. Numerical Approach for Goaf-Side Entry Layout and Yield Pillar Design in Fractured Ground Conditions

    Science.gov (United States)

    Jiang, Lishuai; Zhang, Peipeng; Chen, Lianjun; Hao, Zhen; Sainoki, Atsushi; Mitri, Hani S.; Wang, Qingbiao

    2017-11-01

    Entry driven along goaf-side (EDG), which is the development of an entry of the next longwall panel along the goaf-side and the isolation of the entry from the goaf with a small-width yield pillar, has been widely employed in China over the past several decades . The width of such a yield pillar has a crucial effect on EDG layout in terms of the ground control, isolation effect and resource recovery rate. Based on a case study, this paper presents an approach for evaluating, designing and optimizing EDG and yield pillar by considering the results from numerical simulations and field practice. To rigorously analyze the ground stability, the numerical study begins with the simulation of goaf-side stress and ground conditions. Four global models with identical conditions, except for the width of the yield pillar, are built, and the effect of pillar width on ground stability is investigated by comparing aspects of stress distribution, failure propagation, and displacement evolution during the entire service life of the entry. Based on simulation results, the isolation effect of the pillar acquired from field practice is also considered. The suggested optimal yield pillar design is validated using a field test in the same mine. Thus, the presented numerical approach provides references and can be utilized for the evaluation, design and optimization of EDG and yield pillars under similar geological and geotechnical circumstances.

  18. Comprehensive Review on Divisible Load Theory: Concepts, Strategies, and Approaches

    Directory of Open Access Journals (Sweden)

    Shamsollah Ghanbari

    2014-01-01

    Full Text Available There is extensive literature concerning the divisible load theory. The divisible load theory is mainly applied for scheduling in the area of distributed computing. It is based on the fact that the load can be divided into some arbitrarily independent parts, in which each part can be processed independently by a processor. This paper reviews the literature concerning the divisible load theory, while focusing on the details of the basic concepts, approaches, strategies, typologies, and open problems.

  19. A comprehensive comparison of comparative RNA structure prediction approaches

    DEFF Research Database (Denmark)

    Gardner, P. P.; Giegerich, R.

    2004-01-01

    -finding and multiple-sequence-alignment algorithms. Results Here we evaluate a number of RNA folding algorithms using reliable RNA data-sets and compare their relative performance. Conclusions We conclude that comparative data can enhance structure prediction but structure-prediction-algorithms vary widely in terms......Background An increasing number of researchers have released novel RNA structure analysis and prediction algorithms for comparative approaches to structure prediction. Yet, independent benchmarking of these algorithms is rarely performed as is now common practice for protein-folding, gene...

  20. Reading Approach Use Effectiveness And EFL Reading Comprehension In University Muhammadiyah Of Parepare

    Directory of Open Access Journals (Sweden)

    Baharuddin

    2017-10-01

    Full Text Available This study investigated Indonesian EFL learners approach of two reading approaches cognitive and metacognitive their perceived contact on effectiveness and the association between reading approach and effectiveness on their English reading comprehension. Fifty-Three English-major freshmen from University Muhammadiyah of Parepare participated in these lessons. Two principal questions were addressed 1 what is the most frequent use of reading approach reported by individual students 2 Is there any significant association between reading approach and effectiveness on their English reading comprehension To examine the effects of approach instruction on students reading performance a qualitative interview technique and quantitative research methods including a paired-sample t-test and Person Product Moment Correlation were used to estimate the relationship between reading approach use and effectiveness on students reading accomplishment. Significance showed that the most frequent use of reading approach was found to be metacognitive approach followed by the cognitive approach. In addition there was a significant positive connection between reading approach and effectiveness on their English reading comprehension. Reading approach on the other hand was unrelated to reading achievement. Results of interview findings were analyzed to explore in-depth in sequence about the condition of approach used. The implications of these findings for implementing effective reading strategy instruction are discussed.

  1. The Psychology of Sustainable Seafood Consumption: A Comprehensive Approach.

    Science.gov (United States)

    Richter, Isabel G M; Klöckner, Christian A

    2017-09-28

    This paper discusses conceptual confusions of sustainable seafood consumption, practical challenges, and potential anchors from where this behaviour can be fostered. The main focus lies on psychological variables. The resulting framework comprises (1) a definition of sustainable seafood consumption, (2) suggestions for corresponding behaviours, (3) the identification of facilitating and hindering factors, (4) an assemblage of these factors into a theoretical model, and (5) a short discussion of how the model adds up value to the current state of the art in marine resource conservation. Behavioural models significantly contribute to behavioural change research. The originality and value of this research are that it tackles the so far relatively neglected field of sustainable seafood consumption as important part of sustainable development and marine conservation in the future. From an interventional perspective, the developed model facilitates the identification of contact points to approach consumers and disseminate sustainable seafood consumption among modern Western consumers.

  2. Approaches to achieve high grain yield and high resource use efficiency in rice

    Directory of Open Access Journals (Sweden)

    Jianchang YANG

    2015-06-01

    Full Text Available This article discusses approaches to simultaneously increase grain yield and resource use efficiency in rice. Breeding nitrogen efficient cultivars without sacrificing rice yield potential, improving grain fill in later-flowering inferior spikelets and enhancing harvest index are three important approaches to achieving the dual goal of high grain yield and high resource use efficiency. Deeper root distribution and higher leaf photosynthetic N use efficiency at lower N rates could be used as selection criteria to develop N-efficient cultivars. Enhancing sink activity through increasing sugar-spikelet ratio at the heading time and enhancing the conversion efficiency from sucrose to starch though increasing the ratio of abscisic acid to ethylene in grains during grain fill could effectively improve grain fill in inferior spikelets. Several practices, such as post-anthesis controlled soil drying, an alternate wetting and moderate soil drying regime during the whole growing season, and non-flooded straw mulching cultivation, could substantially increase grain yield and water use efficiency, mainly via enhanced remobilization of stored carbon from vegetative tissues to grains and improved harvest index. Further research is needed to understand synergistic interaction between water and N on crop and soil and the mechanism underlying high resource use efficiency in high-yielding rice.

  3. A Narrative-Expectation-Based Approach to Temporal Update in Discourse Comprehension

    Science.gov (United States)

    Dery, Jeruen E.; Koenig, Jean-Pierre

    2015-01-01

    This study concerns the mechanisms involving temporal update in discourse comprehension, comparing traditional approaches based on "Aktionsart" and Iconicity against an approach based on narrative expectations. Our experiments suggest that readers pay more attention to fine-grained discourse properties (such as salient temporal…

  4. Prediction of biochar yield from cattle manure pyrolysis via least squares support vector machine intelligent approach.

    Science.gov (United States)

    Cao, Hongliang; Xin, Ya; Yuan, Qiaoxia

    2016-02-01

    To predict conveniently the biochar yield from cattle manure pyrolysis, intelligent modeling approach was introduced in this research. A traditional artificial neural networks (ANN) model and a novel least squares support vector machine (LS-SVM) model were developed. For the identification and prediction evaluation of the models, a data set with 33 experimental data was used, which were obtained using a laboratory-scale fixed bed reaction system. The results demonstrated that the intelligent modeling approach is greatly convenient and effective for the prediction of the biochar yield. In particular, the novel LS-SVM model has a more satisfying predicting performance and its robustness is better than the traditional ANN model. The introduction and application of the LS-SVM modeling method gives a successful example, which is a good reference for the modeling study of cattle manure pyrolysis process, even other similar processes. Copyright © 2015 Elsevier Ltd. All rights reserved.

  5. Novel approach to parental permission and child assent for research: improving comprehension.

    Science.gov (United States)

    O'Lonergan, Theresa A; Forster-Harwood, Jeri E

    2011-05-01

    The aim of this research was to test a multimedia permission/assent (P/A) process. The overall hypothesis was that children and their parents exposed to a multimedia P/A process would have better comprehension compared with those exposed to a text-based process. Traditional and multimedia P/A processes were created by using an innovative learning-objective approach. A total of 194 parent-child dyads (children aged 11-14 years) were enrolled: 24 dyads in a prestudy testing P/A components for preference and effect on comprehension and 170 dyads in a randomized trial of a multimedia or paper P/A process for a hypothetical study. Participants were predominantly white and were from a metropolitan area served by a tertiary care pediatric hospital and outpatient facility. Comprehension of 8 essential elements of the P/A process was assessed. The majority of prestudy subjects preferred the video version of the dual-energy radiograph absorptiometry description over the animated and paper versions combined (41 of 48 [85%]; P better overall comprehension compared with the paper P/A process (P = .0009), and there were highly significant differences in understanding of study procedures (P = .0002) and risks (P multimedia group had significantly better overall comprehension (P = .03). Multimedia approaches to the research P/A process may improve overall understanding of research participation for children and parents. Improved understanding of study-specific research components (rather than research rights) may improve overall comprehension.

  6. A new approach to ductile tearing assessment of pipelines under large-scale yielding

    Energy Technology Data Exchange (ETDEWEB)

    Ostby, Erling [SINTEF Materials and Chemistry, N-7465, Trondheim (Norway)]. E-mail: Erling.Obstby@sintef.no; Thaulow, Christian [Norwegian University of Science and Technology, N-7491, Trondheim (Norway); Nyhus, Bard [SINTEF Materials and Chemistry, N-7465, Trondheim (Norway)

    2007-06-15

    In this paper we focus on the issue of ductile tearing assessment for cases with global plasticity, relevant for example to strain-based design of pipelines. A proposal for a set of simplified strain-based driving force equations is used as a basis for calculation of ductile tearing. We compare the traditional approach using the tangency criterion to predict unstable tearing, with a new alternative approach for ductile tearing calculations. A criterion to determine the CTOD at maximum load carrying capacity in the crack ligament is proposed, and used as the failure criterion in the new approach. Compared to numerical reference simulations, the tangency criterion predicts conservative results with regard to the strain capacity. The new approach yields results in better agreement with the reference numerical simulations.

  7. Key observations from a comprehensive FCC study on Canadian heavy gas oils from various origins: 1. Yield profiles in batch reactors

    Energy Technology Data Exchange (ETDEWEB)

    Ng, Siauw H.; Nakajima, Nobumasa [National Centre for Upgrading Technology, 1 Oil Patch Drive, Suite A202, Devon, Alberta (Canada T9G 1A8); Zhu, Yuxia [Research Institute of Petroleum Processing, 18 Xue Yuen Road, P.O. Box 914, Beijing 100083 (China); Humphries, Adrian [Albemarle Catalysts Company LP, 2625 Bay Area Blvd., Suite 250, Houston, TX 77058 (United States); Tsai, Thomas Y.R. [National Dong Hwa University, Hualien 974, Taiwan (ROC); Ding, Fuchen [Beijing Institute of Petrochemical Technology, Daxing, Beijing 102600 (China); Ling, Hao [East China University of Science and Technology, Shanghai 200237 (China); Yui, Sok [Syncrude Research Centre, 9421-17 Avenue, Edmonton, Alberta (Canada T6N 1H4)

    2006-06-15

    A series of cracking tests in a comprehensive study were conducted on separate occasions involving all or parts of 10 Canadian vacuum gas oil (VGO) feeds and a catalyst. VGOs were cracked in fixed- and fluid-bed microactivity test (MAT) units, the Advanced Cracking Evaluation (ACE) unit, and a modified ARCO riser reactor. Several important observations from this study were reported, including the effects of gasoline precursors on the maximum gasoline yields and aromatics in feeds on the conversion levels at which the maximum gasoline yields occurred. Yield profiles were found to be similar in shapes and relative positions between H{sub 2}S-free dry gas and catalytic coke for all but one of the feeds. Conversion and yield data obtained from the three batch reactors were compared and discussed. At a given conversion, correlations existed among the fixed- and fluid-bed MAT units, and the ACE for each product yield. A method to check the qualities of MAT and riser data was demonstrated by plotting the coke or total gas selectivity versus the gasoline selectivity. (author)

  8. The Psychology Department Model Advisement Procedure: A Comprehensive, Systematic Approach to Career Development Advisement

    Science.gov (United States)

    Howell-Carter, Marya; Nieman-Gonder, Jennifer; Pellegrino, Jennifer; Catapano, Brittani; Hutzel, Kimberly

    2016-01-01

    The MAP (Model Advisement Procedure) is a comprehensive, systematic approach to developmental student advisement. The MAP was implemented to improve advisement consistency, improve student preparation for internships/senior projects, increase career exploration, reduce career uncertainty, and, ultimately, improve student satisfaction with the…

  9. Pension Accounting and Reporting with Other Comprehensive Income and Deferred Taxes: A Worksheet Approach

    Science.gov (United States)

    Jackson, Robert E.; Sneathen, L. Dwight, Jr.; Veal, Timothy R.

    2012-01-01

    This instructional tool presents pension accounting using a worksheet approach where debits equal credits for both the employer and for the plan. Transactions associated with the initiation of the plan through the end of the second year of the plan are presented, including their impact on accumulated other comprehensive income and deferred taxes.…

  10. CM5: A pre-Swarm magnetic field model based upon the comprehensive modeling approach

    DEFF Research Database (Denmark)

    Sabaka, T.; Olsen, Nils; Tyler, Robert

    2014-01-01

    We have developed a model based upon the very successful Comprehensive Modeling (CM) approach using recent CHAMP, Ørsted, SAC-C and observatory hourly-means data from September 2000 to the end of 2013. This CM, called CM5, was derived from the algorithm that will provide a consistent line of Leve...

  11. A Novel Approach for Forecasting Crop Production and Yield Using Remotely Sensed Satellite Images

    Science.gov (United States)

    Singh, R. K.; Budde, M. E.; Senay, G. B.; Rowland, J.

    2017-12-01

    Forecasting crop production in advance of crop harvest plays a significant role in drought impact management, improved food security, stabilizing food grain market prices, and poverty reduction. This becomes essential, particularly in Sub-Saharan Africa, where agriculture is a critical source of livelihoods, but lacks good quality agricultural statistical data. With increasing availability of low cost satellite data, faster computing power, and development of modeling algorithms, remotely sensed images are becoming a common source for deriving information for agricultural, drought, and water management. Many researchers have shown that the Normalized Difference Vegetation Index (NDVI), based on red and near-infrared reflectance, can be effectively used for estimating crop production and yield. Similarly, crop production and yield have been closely related to evapotranspiration (ET) also as there are strong linkages between production/yield and transpiration based on plant physiology. Thus, we combined NDVI and ET information from remotely sensed images for estimating total production and crop yield prior to crop harvest for Niger and Burkina Faso in West Africa. We identified the optimum time (dekads 23-29) for cumulating NDVI and ET and developed a new algorithm for estimating crop production and yield. We used the crop data from 2003 to 2008 to calibrate our model and the data from 2009 to 2013 for validation. Our results showed that total crop production can be estimated within 5% of actual production (R2 = 0.98) about 30-45 days before end of the harvest season. This novel approach can be operationalized to provide a valuable tool to decision makers for better drought impact management in drought-prone regions of the world.

  12. A comprehensive & systematic study of coincidence time resolution and light yield using scintillators of different size, wrapping and doping

    CERN Document Server

    Auffray, E.; Geraci, F.; Ghezzi, A.; Gundacker, S.; Hillemanns, H.; Jarron, P.; Meyer, T.; Paganoni, M.; Pauwels, K.; Pizzichemi, M.; Lecoq, P.

    2011-01-01

    Over the last years interest in using time-of-flight-based Positron Emission Tomography (TOF-PET) systems has significantly increased. High time resolution in such PET systems is a powerful tool to improve signal to noise ratio and therefore to allow smaller exposure rates for patients as well as faster image reconstruction. Improvement in coincidence time resolution (CTR) in PET systems to the level of 200ps FWHM requires the optimization of all parameters in the photon detection chain influencing the time resolution: crystal, photodetector and readout electronics. After reviewing the factors influencing the time resolution of scintillators, we will present in this paper the light yield and CTR obtained for different scintillator types (LSO:Ce, LYSO:Ce, LGSO:Ce, LSO:Ce:0.4Ca, LuAG:Ce, LuAG:Pr) with different cross-sections, lengths and reflectors. Whereas light yield measurements were made with a classical PMT, all CTR tests were performed with Hamamatsu-MPPCs or SiPMs S10931-050P. The CTR measurements were ...

  13. The use of fed batch approaches to maximise yields in bacterial fermentation and protein expression

    International Nuclear Information System (INIS)

    McLean, A.

    2001-01-01

    A fermentation facility for the scale up of bacterial and yeast fermentations has been set up at the University of Queensland under the auspices of the ARC Special Research Centre for Functional and Applied Genomics. A major application is the production of recombinant proteins for determination of tertiary structures by X-ray crystallography or nuclear magnetic resonance. For this purpose, large amounts of protein arc needed and the yield from a single fermentation run is crucial to success within constrained laboratory budgets. To achieve maximal yields we are optimising fed batch approaches in bacterial fermentation. Fed batch offers many advantages over batch cultures. Coupled with the ability to monitor online the internal conditions of the fermentation including pH and dissolved oxygen and stirrer cascading functions it is possible to ensure that the nutritional environment of the microorganism is optimised for its growth and or for optimal protein expression. The poster will describe some of our experience in setting up fed batch fermentations and successful applications of fed batches to increasing protein yield. It will also outline services that are available to academic groups outside the University of Queensland For structure determination and functional studies, the production of radiolabelled proteins can also be an advantage. We will describe initial experiments aimed at coupling the principles of fed batch fermentation to the introduction of carbon or nitrogen isotopes into the recombinant protein

  14. Effect of application approaches of ammonium bicarbonate on yield of spring wheat and nitrogen balance

    International Nuclear Information System (INIS)

    Wen Xianfang; Pan Jiarong; Zheng Xingyun

    1995-01-01

    The results from 15 N-tracing experiment showed that at the same rate of nitrogen application, the nitrogen utilization ammonium bicarbonate was 33.50%, 32.30% and 23.19% respectively and the nitrogen loss rate of ammonium bicarbonate was 22.12%, 26.93% and 45.32% respectively for fertilizer mixed thoroughly with soil before sowing, buried into soil and spread on the surface of soil at both joining stage (1/2N) and booting stage (1/2N) of spring wheat. The nitrogen utilization of ammonium bicarbonate for top-application at both joining (1/2N) and booting stage (1/2N) was significantly lower but nitrogen loss rate was significantly higher than that of either thorough incorporation with soil or deep application at joining and booting stages. Between the latter treatments there was no significantly difference observed. There was no significant difference in biomass and grain yield of spring wheat between the former treatment and either of the latter treatments, indicating that buried into soil or mixed with soil thoroughly as a basal fertilizer was an available approach to increase the nitrogen availability of ammonium bicarbonate and crop yield. It was also shown that no significant difference in biomass and grain yield of spring wheat between deep application of ammonium bicarbonate and top-application of urea at the same rate of N application

  15. A generalized approach to wheat yield forecasting using earth observations: Data considerations, application and relevance

    Science.gov (United States)

    Becker-Reshef, Inbal

    In recent years there has been a dramatic increase in the demand for timely, comprehensive global agricultural intelligence. The issue of food security has rapidly risen to the top of government agendas around the world as the recent lack of food access led to unprecedented food prices, hunger, poverty, and civil conflict. Timely information on global crop production is indispensable for combating the growing stress on the world's crop production, for stabilizing food prices, developing effective agricultural policies, and for coordinating responses to regional food shortages. Earth Observations (EO) data offer a practical means for generating such information as they provide global, timely, cost-effective, and synoptic information on crop condition and distribution. Their utility for crop production forecasting has long been recognized and demonstrated across a wide range of scales and geographic regions. Nevertheless it is widely acknowledged that EO data could be better utilized within the operational monitoring systems and thus there is a critical need for research focused on developing practical robust methods for agricultural monitoring. Within this context this dissertation focused on advancing EO-based methods for crop yield forecasting and on demonstrating the potential relevance for adopting EO-based crop forecasts for providing timely reliable agricultural intelligence. This thesis made contributions to this field by developing and testing a robust EO-based method for wheat production forecasting at state to national scales using available and easily accessible data. The model was developed in Kansas (KS) using coarse resolution normalized difference vegetation index (NDVI) time series data in conjunction with out-of-season wheat masks and was directly applied in Ukraine to assess its transferability. The model estimated yields within 7% in KS and 10% in Ukraine of final estimates 6 weeks prior to harvest. The relevance of adopting such methods to

  16. Shotgun Approach to Increasing Enzymatic Saccharification Yields of Ammonia Fiber Expansion Pretreated Cellulosic Biomass

    International Nuclear Information System (INIS)

    Chundawat, Shishir P. S.; Uppugundla, Nirmal; Gao, Dahai; Curran, Paul G.; Balan, Venkatesh; Dale, Bruce E.

    2017-01-01

    Most cellulolytic enzyme blends, either procured from a commercial vendor or isolated from a single cellulolytic microbial secretome, do not efficiently hydrolyze ammonia-pretreated (e.g., ammonia fiber expansion, AFEX) lignocellulosic agricultural crop residues like corn stover to fermentable sugars. Typically reported commercial enzyme loading (30–100 mg protein/g glucan) necessary to achieve >90% total hydrolysis yield (to monosaccharides) for AFEX-treated biomass, within a short saccharification time frame (24–48 h), is economically unviable. Unlike acid-based pretreatments, AFEX retains most of the hemicelluloses in the biomass and therefore requires a more complex suite of enzymes for efficient hydrolysis of cellulose and hemicellulose at industrially relevant high solids loadings. One strategy to reduce enzyme dosage while improving cocktail effectiveness for AFEX-treated biomass has been to use individually purified enzymes to determine optimal enzyme combinations to maximize hydrolysis yields. However, this approach is limited by the selection of heterologous enzymes available or the labor required for isolating low-abundance enzymes directly from the microbial secretomes. Here, we show that directly blending crude cellulolytic and hemicellulolytic enzymes-rich microbial secretomes can maximize specific activity on AFEX-treated biomass without having to isolate individual enzymes. Fourteen commercially available cellulolytic and hemicellulolytic enzymes were procured from leading enzyme companies (Novozymes ® , Genencor ® , and Biocatalysts ® ) and were mixed together to generate several hundred unique cocktail combinations. The mixtures were assayed for activity on AFEX-treated corn stover (AFEX-CS) using a previously established high-throughput methodology. The optimal enzyme blend combinations identified from these screening assays were enriched in various low-abundance hemicellulases and accessory enzymes typically absent in most commercial

  17. Review of yield gap explaining factors and opportunities for alternative data collection approaches

    NARCIS (Netherlands)

    Beza, E.A.; Vasco Silva, João; Kooistra, Lammert; Reidsma, Pytrik

    2017-01-01

    Yield gap analysis is gaining increased scientific attention, as estimating and explaining yield gaps shows the potential for sustainable intensification of agricultural systems. Explaining yield gaps requires detailed information about the biophysical environment, crop management as well as

  18. A comprehensive approach to benefit-risk assessment in drug development

    DEFF Research Database (Denmark)

    Sarac, Sinan B; Rasmussen, Christian H; Rasmussen, Morten A.

    2012-01-01

    Major regulatory agencies, for example, FDA and EMA, have started to request comprehensive benefit-risk analyses of pharmaceutical products prior to approval or labelling expansion. The purpose of this study is to develop a generally applicable and reliable data-driven benefit-risk assessment......) discussion and formulation of an overall conclusion. To reduce the impact of subjective judgements, scores are assigned to each criterion on the basis of objective information (data) wherever possible. The proposed benefit-risk evaluation approach offers comprehensive, data-driven assessments that can...... method, where two or more drugs/doses can be compared. Our aim is to formulate an approach that is simple to apply, allows direct comparison of different types of risks and benefits, and is tailored for application in different disease areas both during clinical development and in the marketing approval...

  19. The evolution of NATO’s comprehensive approach to crisis management operations

    Directory of Open Access Journals (Sweden)

    Guillem Colom Piella

    2012-04-01

    Full Text Available The crisis management operations, post-war stabilisation and nation-building that has taken place since the end of the Cold War has all highlighted the extreme need to harmonise multinational and inter-agency cooperation in order to increase the coherence and effectiveness of the operation. That is the basic principle of Comprehensive Approach, which is defined as the coordination of strategies and actions of the participating actors in crisis management and at all levels, stages and planes of same. The NATO has also incorporated these advances into the area of crisis management, as a result of which, since 2006, it has been defining its own concept of Comprehensive Approach for non-Article 5 missions, and as a central theme in its political-military strategy for the present and immediate future.

  20. Repository documentation rethought. A comprehensive approach from untreated waste to waste packages for final disposal

    Energy Technology Data Exchange (ETDEWEB)

    Anthofer, Anton Philipp; Schubert, Johannes [VPC GmbH, Dresden (Germany)

    2017-11-15

    The German Act on Reorganization of Responsibility for Nuclear Disposal (Entsorgungsuebergangsgesetz (EntsorgUebG)) adopted in June 2017 provides the energy utilities with the new option of transferring responsibility for their waste packages to the Federal Government. This is conditional on the waste packages being approved for delivery to the Konrad final repository. A comprehensive approach starts with the dismantling of nuclear facilities and extends from waste disposal and packaging planning to final repository documentation. Waste package quality control measures are planned and implemented as early as in the process qualification stage so that the production of waste packages that are suitable for final deposition can be ensured. Optimization of cask and loading configuration can save container and repository volume. Workflow planning also saves time, expenditure and exposure time for personnel at the facilities. VPC has evaluated this experience and developed it into a comprehensive approach.

  1. An analysis of clinical reasoning through a recent and comprehensive approach: the dual-process theory

    OpenAIRE

    Pelaccia, Thierry; Tardif, Jacques; Triby, Emmanuel; Charlin, Bernard

    2011-01-01

    Context: Clinical reasoning plays a major role in the ability of doctors to make diagnoses and decisions. It is considered as the physician’s most critical competence, and has been widely studied by physicians, educationalists, psychologists and sociologists. Since the 1970s, many theories about clinical reasoning in medicine have been put forward. Purpose: This paper aims at exploring a comprehensive approach: the ‘‘dual-process theory’’, a model developed by co...

  2. Developing a Comprehensive Approach Could Help DOD Better Manage National Security Risks in the Supply Chain

    Science.gov (United States)

    2016-02-01

    supply chains for rare earths.20 According to Industrial Analysis Center officials, only 10 percent of surveys sent to prime contractors for 79...the Supply Chain Report to Congressional Committees February 2016 GAO-16-161 United States Government Accountability Office United...Developing a Comprehensive Approach Could Help DOD Better Manage National Security Risks in the Supply Chain Why GAO Did This Study DOD depends on

  3. Assessing Weather-Yield Relationships in Rice at Local Scale Using Data Mining Approaches.

    Directory of Open Access Journals (Sweden)

    Sylvain Delerce

    Full Text Available Seasonal and inter-annual climate variability have become important issues for farmers, and climate change has been shown to increase them. Simultaneously farmers and agricultural organizations are increasingly collecting observational data about in situ crop performance. Agriculture thus needs new tools to cope with changing environmental conditions and to take advantage of these data. Data mining techniques make it possible to extract embedded knowledge associated with farmer experiences from these large observational datasets in order to identify best practices for adapting to climate variability. We introduce new approaches through a case study on irrigated and rainfed rice in Colombia. Preexisting observational datasets of commercial harvest records were combined with in situ daily weather series. Using Conditional Inference Forest and clustering techniques, we assessed the relationships between climatic factors and crop yield variability at the local scale for specific cultivars and growth stages. The analysis showed clear relationships in the various location-cultivar combinations, with climatic factors explaining 6 to 46% of spatiotemporal variability in yield, and with crop responses to weather being non-linear and cultivar-specific. Climatic factors affected cultivars differently during each stage of development. For instance, one cultivar was affected by high nighttime temperatures in the reproductive stage but responded positively to accumulated solar radiation during the ripening stage. Another was affected by high nighttime temperatures during both the vegetative and reproductive stages. Clustering of the weather patterns corresponding to individual cropping events revealed different groups of weather patterns for irrigated and rainfed systems with contrasting yield levels. Best-suited cultivars were identified for some weather patterns, making weather-site-specific recommendations possible. This study illustrates the potential of

  4. Assessing Weather-Yield Relationships in Rice at Local Scale Using Data Mining Approaches.

    Science.gov (United States)

    Delerce, Sylvain; Dorado, Hugo; Grillon, Alexandre; Rebolledo, Maria Camila; Prager, Steven D; Patiño, Victor Hugo; Garcés Varón, Gabriel; Jiménez, Daniel

    2016-01-01

    Seasonal and inter-annual climate variability have become important issues for farmers, and climate change has been shown to increase them. Simultaneously farmers and agricultural organizations are increasingly collecting observational data about in situ crop performance. Agriculture thus needs new tools to cope with changing environmental conditions and to take advantage of these data. Data mining techniques make it possible to extract embedded knowledge associated with farmer experiences from these large observational datasets in order to identify best practices for adapting to climate variability. We introduce new approaches through a case study on irrigated and rainfed rice in Colombia. Preexisting observational datasets of commercial harvest records were combined with in situ daily weather series. Using Conditional Inference Forest and clustering techniques, we assessed the relationships between climatic factors and crop yield variability at the local scale for specific cultivars and growth stages. The analysis showed clear relationships in the various location-cultivar combinations, with climatic factors explaining 6 to 46% of spatiotemporal variability in yield, and with crop responses to weather being non-linear and cultivar-specific. Climatic factors affected cultivars differently during each stage of development. For instance, one cultivar was affected by high nighttime temperatures in the reproductive stage but responded positively to accumulated solar radiation during the ripening stage. Another was affected by high nighttime temperatures during both the vegetative and reproductive stages. Clustering of the weather patterns corresponding to individual cropping events revealed different groups of weather patterns for irrigated and rainfed systems with contrasting yield levels. Best-suited cultivars were identified for some weather patterns, making weather-site-specific recommendations possible. This study illustrates the potential of data mining for

  5. A nonlinear dynamical system approach for the yielding behaviour of a viscoplastic material.

    Science.gov (United States)

    Burghelea, Teodor; Moyers-Gonzalez, Miguel; Sainudiin, Raazesh

    2017-03-08

    A nonlinear dynamical system model that approximates a microscopic Gibbs field model for the yielding of a viscoplastic material subjected to varying external stresses recently reported in R. Sainudiin, M. Moyers-Gonzalez and T. Burghelea, Soft Matter, 2015, 11(27), 5531-5545 is presented. The predictions of the model are in fair agreement with microscopic simulations and are in very good agreement with the micro-structural semi-empirical model reported in A. M. V. Putz and T. I. Burghelea, Rheol. Acta, 2009, 48, 673-689. With only two internal parameters, the nonlinear dynamical system model captures several key features of the solid-fluid transition observed in experiments: the effect of the interactions between microscopic constituents on the yield point, the abruptness of solid-fluid transition and the emergence of a hysteresis of the micro-structural states upon increasing/decreasing external forces. The scaling behaviour of the magnitude of the hysteresis with the degree of the steadiness of the flow is consistent with previous experimental observations. Finally, the practical usefulness of the approach is demonstrated by fitting a rheological data set measured with an elasto-viscoplastic material.

  6. Manifestation of external size reduction effects on the yield point of nanocrystalline rhodium using nanopillars approach

    International Nuclear Information System (INIS)

    Alshehri, Omar; Yavuz, Mustafa; Tsui Ting

    2013-01-01

    In this study, pure rhodium was fabricated and mechanically investigated at the nanoscale for the first time. The nanopillars approach was employed to study the effects of size on the yield point. Nanopillars with different diameters were fabricated using electroplating followed by uniaxial compression tests. Scanning electron microscopy (SEM) was used as a quality control technique by imaging the pillars before and after compression to ensure the absence of cracks, buckling, barrelling or any other problems. Transmission electron microscopy and SEM were used as microstructural characterization techniques. Due to substrate-induced effects, only the plastic region of the stress–strain curves were investigated, and it was revealed that the yield point increases with size reduction up to certain limit, then decreases with further reduction of the nanopillar size (diameter). The later weakening effect is consistent with the literature, which demonstrates the reversed size effect (the failure of the plasticity theory) in nanocrystalline metals, i.e. smaller is weaker. In this study, however, the effect of size reduction is not only weakening, but is strengthening-then-weakening, which the authors believe is the true behavior of nanocrystalline materials.

  7. A comprehensive inversion approach for feedforward compensation of piezoactuator system at high frequency

    Science.gov (United States)

    Tian, Lizhi; Xiong, Zhenhua; Wu, Jianhua; Ding, Han

    2016-09-01

    Motion control of the piezoactuator system over broadband frequencies is limited due to its inherent hysteresis and system dynamics. One of the suggested ways is to use feedforward controller to linearize the input-output relationship of the piezoactuator system. Although there have been many feedforward approaches, it is still a challenge to develop feedforward controller for the piezoactuator system at high frequency. Hence, this paper presents a comprehensive inversion approach in consideration of the coupling of hysteresis and dynamics. In this work, the influence of dynamics compensation on the input-output relationship of the piezoactuator system is investigated first. With system dynamics compensation, the input-output relationship of the piezoactuator system will be further represented as rate-dependent nonlinearity due to the inevitable dynamics compensation error, especially at high frequency. Base on this result, the feedforward controller composed by a cascade of linear dynamics inversion and rate-dependent nonlinearity inversion is developed. Then, the system identification of the comprehensive inversion approach is proposed. Finally, experimental results show that the proposed approach can improve the performance on tracking of both periodic and non-periodic trajectories at medium and high frequency compared with the conventional feedforward approaches.

  8. Key Concept Identification: A Comprehensive Analysis of Frequency and Topical Graph-Based Approaches

    Directory of Open Access Journals (Sweden)

    Muhammad Aman

    2018-05-01

    Full Text Available Automatic key concept extraction from text is the main challenging task in information extraction, information retrieval and digital libraries, ontology learning, and text analysis. The statistical frequency and topical graph-based ranking are the two kinds of potentially powerful and leading unsupervised approaches in this area, devised to address the problem. To utilize the potential of these approaches and improve key concept identification, a comprehensive performance analysis of these approaches on datasets from different domains is needed. The objective of the study presented in this paper is to perform a comprehensive empirical analysis of selected frequency and topical graph-based algorithms for key concept extraction on three different datasets, to identify the major sources of error in these approaches. For experimental analysis, we have selected TF-IDF, KP-Miner and TopicRank. Three major sources of error, i.e., frequency errors, syntactical errors and semantical errors, and the factors that contribute to these errors are identified. Analysis of the results reveals that performance of the selected approaches is significantly degraded by these errors. These findings can help us develop an intelligent solution for key concept extraction in the future.

  9. A Novel Modelling Approach for Predicting Forest Growth and Yield under Climate Change.

    Directory of Open Access Journals (Sweden)

    M Irfan Ashraf

    Full Text Available Global climate is changing due to increasing anthropogenic emissions of greenhouse gases. Forest managers need growth and yield models that can be used to predict future forest dynamics during the transition period of present-day forests under a changing climatic regime. In this study, we developed a forest growth and yield model that can be used to predict individual-tree growth under current and projected future climatic conditions. The model was constructed by integrating historical tree growth records with predictions from an ecological process-based model using neural networks. The new model predicts basal area (BA and volume growth for individual trees in pure or mixed species forests. For model development, tree-growth data under current climatic conditions were obtained using over 3000 permanent sample plots from the Province of Nova Scotia, Canada. Data to reflect tree growth under a changing climatic regime were projected with JABOWA-3 (an ecological process-based model. Model validation with designated data produced model efficiencies of 0.82 and 0.89 in predicting individual-tree BA and volume growth. Model efficiency is a relative index of model performance, where 1 indicates an ideal fit, while values lower than zero means the predictions are no better than the average of the observations. Overall mean prediction error (BIAS of basal area and volume growth predictions was nominal (i.e., for BA: -0.0177 cm(2 5-year(-1 and volume: 0.0008 m(3 5-year(-1. Model variability described by root mean squared error (RMSE in basal area prediction was 40.53 cm(2 5-year(-1 and 0.0393 m(3 5-year(-1 in volume prediction. The new modelling approach has potential to reduce uncertainties in growth and yield predictions under different climate change scenarios. This novel approach provides an avenue for forest managers to generate required information for the management of forests in transitional periods of climate change. Artificial intelligence

  10. Shotgun Approach to Increasing Enzymatic Saccharification Yields of Ammonia Fiber Expansion Pretreated Cellulosic Biomass

    Energy Technology Data Exchange (ETDEWEB)

    Chundawat, Shishir P. S., E-mail: shishir.chundawat@rutgers.edu [Department of Chemical and Biochemical Engineering, Rutgers-State University of New Jersey, Piscataway, NJ (United States); Uppugundla, Nirmal; Gao, Dahai [Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI (United States); Curran, Paul G. [Center for Statistical Training and Consulting (CSTAT), Michigan State University, East Lansing, MI (United States); Balan, Venkatesh; Dale, Bruce E. [Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI (United States)

    2017-05-10

    Most cellulolytic enzyme blends, either procured from a commercial vendor or isolated from a single cellulolytic microbial secretome, do not efficiently hydrolyze ammonia-pretreated (e.g., ammonia fiber expansion, AFEX) lignocellulosic agricultural crop residues like corn stover to fermentable sugars. Typically reported commercial enzyme loading (30–100 mg protein/g glucan) necessary to achieve >90% total hydrolysis yield (to monosaccharides) for AFEX-treated biomass, within a short saccharification time frame (24–48 h), is economically unviable. Unlike acid-based pretreatments, AFEX retains most of the hemicelluloses in the biomass and therefore requires a more complex suite of enzymes for efficient hydrolysis of cellulose and hemicellulose at industrially relevant high solids loadings. One strategy to reduce enzyme dosage while improving cocktail effectiveness for AFEX-treated biomass has been to use individually purified enzymes to determine optimal enzyme combinations to maximize hydrolysis yields. However, this approach is limited by the selection of heterologous enzymes available or the labor required for isolating low-abundance enzymes directly from the microbial secretomes. Here, we show that directly blending crude cellulolytic and hemicellulolytic enzymes-rich microbial secretomes can maximize specific activity on AFEX-treated biomass without having to isolate individual enzymes. Fourteen commercially available cellulolytic and hemicellulolytic enzymes were procured from leading enzyme companies (Novozymes{sup ®}, Genencor{sup ®}, and Biocatalysts{sup ®}) and were mixed together to generate several hundred unique cocktail combinations. The mixtures were assayed for activity on AFEX-treated corn stover (AFEX-CS) using a previously established high-throughput methodology. The optimal enzyme blend combinations identified from these screening assays were enriched in various low-abundance hemicellulases and accessory enzymes typically absent in most

  11. The Effect of Integrated Learning-Teaching Approach on Reading Comprehension and Narration Skills

    Directory of Open Access Journals (Sweden)

    Ergün Hamzadayı

    2010-12-01

    Full Text Available This study investigated the effects of integrated learning-teaching approach on reading comprehension and narration skills. Considerations regarding how to overcome difficulties in the teaching of Turkish language through multi-theoretical perspectives have resulted in this approach to come into the existence. For the purpose of forming theoretical foundations of the research, behaviourist, cognitive and constructivist learning theories with their philosophical foundations were introduced, their principals and assumptions with regard to instructional design were compared, and their strengths and weakness were delineated. These considerations were then associated with the components of Turkish language program (content, objectives, teaching strategies and methods, assessment and that paved way for “integrative learning and teaching approach” to come into being. This study aimed to investigate whether there is a significant difference between the performance of the experimental group students who were exposed to integrative learning and teaching approach and that of control group students who were not exposed to integrative learning and teaching approach in terms of reading comprehension and written expression skills in Turkish language

  12. Comprehensive Approach for Monitoring and Analyzing the Activity Concentration Level of PET Isotopes

    International Nuclear Information System (INIS)

    Osovizky, A.; Paran, J.; Ankry, N.; Vulasky, E.; Ashkenazi, B.; Tal, N.; Dolev, E.; Gonen, E.

    2004-01-01

    A comprehensive approach for measuring and analyzing low concentration levels of positron emitter isotopes is introduced. The solution is based on a Continuous Air Monitoring Sampler (CAMS), Stack Monitoring System (SMS) and software package. Positron Emission Tomography (PET) is a major tool for both, biochemical research and non-invasive diagnostics for medicine imaging. The PET method utilizes short half life β + radioisotopes that are produced in cyclotron sites built especially for this purpose. The growing need for β + isotopes brought about a commonly wide use of cyclotrons next to populated areas. Isotopes production involves two possible radiation hazards deriving from the activity concentration; one refers to the nearby population by the activity released through the ventilation system and the other refers to the personnel working in the nuclear facility. A comprehensive system providing solution for both radiation hazards is introduced in this work

  13. Reading Comprehension Course Through a Genre-Oriented Approach at a School in Colombia

    Directory of Open Access Journals (Sweden)

    Andrés Rodríguez Sánchez

    2017-07-01

    Full Text Available This paper reports on an action-research study aimed at identifying the problems and needs of a specific group of tenth graders at a school in Colombia in relation to their reading comprehension in English in order to design, partially implement, and evaluate a genre-oriented syllabus. Findings show that the explicit instruction of metacognitive strategies helped students become more efficient readers, as well as the fact that the exposure and analysis of genres developed a better comprehension of different kinds of texts, making these students aware of the structure and patterns of the texts they were reading as they approached them with reading strategies that were appropriate for each genre and stage.

  14. A Comprehensive Review on Handcrafted and Learning-Based Action Representation Approaches for Human Activity Recognition

    Directory of Open Access Journals (Sweden)

    Allah Bux Sargano

    2017-01-01

    Full Text Available Human activity recognition (HAR is an important research area in the fields of human perception and computer vision due to its wide range of applications. These applications include: intelligent video surveillance, ambient assisted living, human computer interaction, human-robot interaction, entertainment, and intelligent driving. Recently, with the emergence and successful deployment of deep learning techniques for image classification, researchers have migrated from traditional handcrafting to deep learning techniques for HAR. However, handcrafted representation-based approaches are still widely used due to some bottlenecks such as computational complexity of deep learning techniques for activity recognition. However, approaches based on handcrafted representation are not able to handle complex scenarios due to their limitations and incapability; therefore, resorting to deep learning-based techniques is a natural option. This review paper presents a comprehensive survey of both handcrafted and learning-based action representations, offering comparison, analysis, and discussions on these approaches. In addition to this, the well-known public datasets available for experimentations and important applications of HAR are also presented to provide further insight into the field. This is the first review paper of its kind which presents all these aspects of HAR in a single review article with comprehensive coverage of each part. Finally, the paper is concluded with important discussions and research directions in the domain of HAR.

  15. Multiple flood vulnerability assessment approach based on fuzzy comprehensive evaluation method and coordinated development degree model.

    Science.gov (United States)

    Yang, Weichao; Xu, Kui; Lian, Jijian; Bin, Lingling; Ma, Chao

    2018-05-01

    Flood is a serious challenge that increasingly affects the residents as well as policymakers. Flood vulnerability assessment is becoming gradually relevant in the world. The purpose of this study is to develop an approach to reveal the relationship between exposure, sensitivity and adaptive capacity for better flood vulnerability assessment, based on the fuzzy comprehensive evaluation method (FCEM) and coordinated development degree model (CDDM). The approach is organized into three parts: establishment of index system, assessment of exposure, sensitivity and adaptive capacity, and multiple flood vulnerability assessment. Hydrodynamic model and statistical data are employed for the establishment of index system; FCEM is used to evaluate exposure, sensitivity and adaptive capacity; and CDDM is applied to express the relationship of the three components of vulnerability. Six multiple flood vulnerability types and four levels are proposed to assess flood vulnerability from multiple perspectives. Then the approach is applied to assess the spatiality of flood vulnerability in Hainan's eastern area, China. Based on the results of multiple flood vulnerability, a decision-making process for rational allocation of limited resources is proposed and applied to the study area. The study shows that multiple flood vulnerability assessment can evaluate vulnerability more completely, and help decision makers learn more information about making decisions in a more comprehensive way. In summary, this study provides a new way for flood vulnerability assessment and disaster prevention decision. Copyright © 2018 Elsevier Ltd. All rights reserved.

  16. Model-based approach for maize yield gap analysis related to climate variability and nitrogen management

    OpenAIRE

    Maria Carolina da Silva Andréa

    2016-01-01

    To achieve food security and meet environmental requirements, the average rates of major crop yields in crops such as maize are expected to increase instead of expansion of cultivated areas. Maize crop has as main factors responsible for the low yields in Brazil the water and nitrogen (N) deficits. The concept of yield gaps is the difference between the maximum yield that can be achieved in a given place, limited by water (Yw) or not (Yp), and the average yields, observed under practical cond...

  17. Implementing a cumulative supermatrix approach for a comprehensive phylogenetic study of the Teloschistales (Pezizomycotina, Ascomycota)

    DEFF Research Database (Denmark)

    Gaya, Ester; Högnabba, Filip; Holguin, Ángela

    2012-01-01

    The resolution of the phylogenetic relationships within the order Teloschistales (Ascomycota, lichen-forming-fungi), with nearly 2000 known species and outstanding phenotypic diversity, has been hindered by the limitation in the resolving power that single-locus or two-locus phylogenetic studies...... – the Megalosporaceae – which is sister to the mainly rock-inhabiting, cosmopolitan, and species rich Teloschistaceae, with a diversity of growth habits ranging from crustose to fruticose. Our results confirm the use of a cumulative supermatrix approach as a viable method to generate comprehensive phylogenies...

  18. NeuroVRAC--a comprehensive approach to virtual reality-based neurological assessment and treatment systems.

    Science.gov (United States)

    Valvoda, Jakob T; Assenmacher, Ingo; Dohle, Christian; Kuhlen, Torsten; Bischof, Christian

    2003-01-01

    We describe a comprehensive software-oriented approach to virtual reality-based neuroscientific systems in order to establish an easy to use framework for neuroscientific assessment and treatment. We have defined a process model and implemented the NeuroVRAC authoring tool for design and execution of experiments in virtual environments. Our system enables the modeling of virtual world objects and the definition of events, which are used to control the experimental process. We have included the virtual test person concept to enhance the sense of presence during the execution of virtual reality-based neuroscientific experiments.

  19. Measuring the immune system: a comprehensive approach for the analysis of immune functions in humans.

    Science.gov (United States)

    Claus, Maren; Dychus, Nicole; Ebel, Melanie; Damaschke, Jürgen; Maydych, Viktoriya; Wolf, Oliver T; Kleinsorge, Thomas; Watzl, Carsten

    2016-10-01

    The immune system is essential to provide protection from infections and cancer. Disturbances in immune function can therefore directly affect the health of the affected individual. Many extrinsic and intrinsic factors such as exposure to chemicals, stress, nutrition and age have been reported to influence the immune system. These influences can affect various components of the immune system, and we are just beginning to understand the causalities of these changes. To investigate such disturbances, it is therefore essential to analyze the different components of the immune system in a comprehensive fashion. Here, we demonstrate such an approach which provides information about total number of leukocytes, detailed quantitative and qualitative changes in the composition of lymphocyte subsets, cytokine levels in serum and functional properties of T cells, NK cells and monocytes. Using samples from a cohort of 24 healthy volunteers, we demonstrate the feasibility of our approach to detect changes in immune functions.

  20. Seeing the whole picture: A comprehensive imaging approach to functional mapping of circuits in behaving zebrafish.

    Science.gov (United States)

    Feierstein, C E; Portugues, R; Orger, M B

    2015-06-18

    In recent years, the zebrafish has emerged as an appealing model system to tackle questions relating to the neural circuit basis of behavior. This can be attributed not just to the growing use of genetically tractable model organisms, but also in large part to the rapid advances in optical techniques for neuroscience, which are ideally suited for application to the small, transparent brain of the larval fish. Many characteristic features of vertebrate brains, from gross anatomy down to particular circuit motifs and cell-types, as well as conserved behaviors, can be found in zebrafish even just a few days post fertilization, and, at this early stage, the physical size of the brain makes it possible to analyze neural activity in a comprehensive fashion. In a recent study, we used a systematic and unbiased imaging method to record the pattern of activity dynamics throughout the whole brain of larval zebrafish during a simple visual behavior, the optokinetic response (OKR). This approach revealed the broadly distributed network of neurons that were active during the behavior and provided insights into the fine-scale functional architecture in the brain, inter-individual variability, and the spatial distribution of behaviorally relevant signals. Combined with mapping anatomical and functional connectivity, targeted electrophysiological recordings, and genetic labeling of specific populations, this comprehensive approach in zebrafish provides an unparalleled opportunity to study complete circuits in a behaving vertebrate animal. Copyright © 2014. Published by Elsevier Ltd.

  1. Simple, spatial and predictive approach for cereal yield prediction in the semi-arid areas

    Science.gov (United States)

    Toumi, Jihad; Khabba, Said; Er-Raki, Salah; Le page, Michel; Chahbi Bellakanji, Aicha; Lili Chabaane, Zohra; Ezzahar, Jamal; Zribi, Mehrez; Jarlan, Lionel

    2016-04-01

    The objective is to develop a simple, spatial and predictive approach of dry matter (DM) and grain yield (GY) of cereal in the semi-arid areas. The proposed method is based on the three efficiencies model of Monteith (1972). This approach summarizes the transformation of solar radiation to the dry matter (DM) by the climate (ɛc), interception (ɛi) and conversion (ɛconv) efficiencies. The method combines the maximum of ɛi and ɛconv (noted ɛimax and ɛconvmax) into a single parameter denoted ɛmax, calculating as a function of cumulating growing degree day (CGDD). Also, the stress coefficient ks, which affects the conversion of solar radiation to the biomass was calculated by the surface temperature or the water balance at the root zone. In addition, the expression of ks has been improved by the consideration of the results achieved by deficit irrigation (AquaCrop and STICS models) which showed that the value of ks from 0.7 to 1 didn't affect significantly the cereal production. For the partitioning of the dry matter developed, between straw and grain, the method proposed calculates a variable Harvest Index coefficient (HI). HI is deducted from CGDD and HI0max (maximal final harvest Index in the region of study). Finally, the approach calculates DM depending Satellite Information (NDVI and surface temperature Ts) and climatic data (solar radiation and air temperature). In the case of no availability of Ts, the amount of irrigation is required to calculate ks. Until now, the developed model has been calibrated and validated on the irrigated area R3, located 40 Km east of Marrakech. The evolutions of DM and GY were reproduced satisfactorily. R2 and RMSE are respectively 0.98 and 0.35 t/ha and 0.98 and 0.19 t/ha, respectively. Currently, additional tests are in progress on data relating to the Kairouan plain of Tunisia.

  2. New approach for regional crop yield gap analysis in the Borujen ...

    African Journals Online (AJOL)

    enoh

    2012-03-20

    Mar 20, 2012 ... for model calibration and evaluation of WOFOST as a crop growth ... In general, simulated results matched well with the measured ... regional-scale yield prediction and assessment (Jagtap ... the benchmark value and most of the variation in yield ... The model simulates daily crop growth rate, based on.

  3. Multidisciplinary and comprehensive approaches to optimal management of chronic pressure ulcers in the elderly

    Directory of Open Access Journals (Sweden)

    Jaul E

    2014-05-01

    Full Text Available Efraim Jaul Skilled Geriatric Nursing Department, Herzog Memorial Hospital, Affiliated to the Hebrew University Hadassah Medical School, Jerusalem, Israel Abstract: The occurrence of pressure ulcers (PUs is common and poses serious problems for the frail elderly, with implications for functional disability and reduced quality of life. PUs are preventable in a majority of cases. The increase in PU occurrence, however, appears regardless of higher awareness in prevention and improvement through utilization of pressure relieving devices. Multiple changes in the elderly body systems occur over time including aging, multiple chronic conditions, and functional impairment, potentially culminating in the final pathways of geriatric syndrome, unless awareness to the development of PUs is reversible and prevented. The assumption is that the development of PUs is based on multifactorial causes (extrinsic and intrinsic factors; thus, the optimal management for elderly patients requires a comprehensive approach in all medical settings (community, hospital, and at the long term care [LTC] level. Comprehensiveness signifies looking beyond the wounds, assisting the patient through both local (wound and systemic (medical condition treatment, using a strategy of prevention and supporting quality of life. Within the multidisciplinary involvement team approach, each professional discipline contributes its own task in coordination with other disciplines to address PU prevention, assessment, and treatment. The entire medical staff and the multidisciplinary team work together and communicate frequently in order to prevent, halt at an early stage, and provide healing in a timely fashion. Limiting the formation of PUs is facilitated through early identification, treating contributing causes, eliminating all unnecessary medications, instituting supportive interventions which include the family. Understanding the relationship between the formation of PUs and the

  4. Assessing Viability and Sustainability: a Systems-based Approach for Deriving Comprehensive Indicator Sets

    Directory of Open Access Journals (Sweden)

    Hartmut Bossel

    2002-01-01

    Full Text Available Performance assessment in holistic approaches such as integrated natural resource management has to deal with a complex set of interacting and self-organizing natural and human systems and agents, all pursuing their own "interests" while also contributing to the development of the total system. Performance indicators must therefore reflect the viability of essential component systems as well as their contributions to the viability and performance of other component systems and the total system under study. A systems-based derivation of a comprehensive set of performance indicators first requires the identification of essential component systems, their mutual (often hierarchical or reciprocal relationships, and their contributions to the performance of other component systems and the total system. The second step consists of identifying the indicators that represent the viability states of the component systems and the contributions of these component systems to the performance of the total system. The search for performance indicators is guided by the realization that essential interests (orientations or orientors of systems and actors are shaped by both their characteristic functions and the fundamental and general properties of their system environments (e.g., normal environmental state, scarcity of resources, variety, variability, change, other coexisting systems. To be viable, a system must devote an essential minimum amount of attention to satisfying the "basic orientors" that respond to the properties of its environment. This fact can be used to define comprehensive and system-specific sets of performance indicators that reflect all important concerns. Often, qualitative indicators and the study of qualitative systems are sufficient for reliable performance assessments. However, this approach can also be formalized for quantitative computer-assisted assessment. Examples are presented of indicator sets for the sustainable development of

  5. A comprehensive iterative approach is highly effective in diagnosing individuals who are exome negative.

    Science.gov (United States)

    Shashi, Vandana; Schoch, Kelly; Spillmann, Rebecca; Cope, Heidi; Tan, Queenie K-G; Walley, Nicole; Pena, Loren; McConkie-Rosell, Allyn; Jiang, Yong-Hui; Stong, Nicholas; Need, Anna C; Goldstein, David B

    2018-06-15

    Sixty to seventy-five percent of individuals with rare and undiagnosed phenotypes remain undiagnosed after exome sequencing (ES). With standard ES reanalysis resolving 10-15% of the ES negatives, further approaches are necessary to maximize diagnoses in these individuals. In 38 ES negative patients an individualized genomic-phenotypic approach was employed utilizing (1) phenotyping; (2) reanalyses of FASTQ files, with innovative bioinformatics; (3) targeted molecular testing; (4) genome sequencing (GS); and (5) conferring of clinical diagnoses when pathognomonic clinical findings occurred. Certain and highly likely diagnoses were made in 18/38 (47%) individuals, including identifying two new developmental disorders. The majority of diagnoses (>70%) were due to our bioinformatics, phenotyping, and targeted testing identifying variants that were undetected or not prioritized on prior ES. GS diagnosed 3/18 individuals with structural variants not amenable to ES. Additionally, tentative diagnoses were made in 3 (8%), and in 5 individuals (13%) candidate genes were identified. Overall, diagnoses/potential leads were identified in 26/38 (68%). Our comprehensive approach to ES negatives maximizes the ES and clinical data for both diagnoses and candidate gene identification, without GS in the majority. This iterative approach is cost-effective and is pertinent to the current conundrum of ES negatives.

  6. System dynamics approach for modeling of sugar beet yield considering the effects of climatic variables.

    Science.gov (United States)

    Pervin, Lia; Islam, Md Saiful

    2015-02-01

    The aim of this study was to develop a system dynamics model for computation of yields and to investigate the dependency of yields on some major climatic parameters, i.e. temperature and rainfall, for Beta vulgaris subsp. (sugar beet crops) under future climate change scenarios. A system dynamics model was developed which takes account of the effects of rainfall and temperature on sugar beet yields under limited irrigation conditions. A relationship was also developed between the seasonal evapotranspiration and seasonal growing degree days for sugar beet crops. The proposed model was set to run for the present time period of 1993-2012 and for the future period 2013-2040 for Lethbridge region (Alberta, Canada). The model provides sugar beet yields on a yearly basis which are comparable to the present field data. It was found that the future average yield will be increased at about 14% with respect to the present average yield. The proposed model can help to improve the understanding of soil water conditions and irrigation water requirements of an area under certain climatic conditions and can be used for future prediction of yields for any crops in any region (with the required information to be provided). The developed system dynamics model can be used as a supporting tool for decision making, for improvement of agricultural management practice of any region. © 2014 Society of Chemical Industry.

  7. Integrating multiple programme and policy approaches to hepatitis C prevention and care for injection drug users: a comprehensive approach.

    Science.gov (United States)

    Birkhead, Guthrie S; Klein, Susan J; Candelas, Alma R; O'Connell, Daniel A; Rothman, Jeffrey R; Feldman, Ira S; Tsui, Dennis S; Cotroneo, Richard A; Flanigan, Colleen A

    2007-10-01

    New York State is home to an estimated 230,000 individuals chronically infected with hepatitis C virus (HCV) and roughly 171,500 active injection drug users (IDUs). HCV/HIV co-infection is common and models of service delivery that effectively meet IDUs' needs are required. A HCV strategic plan has stressed integration. HCV prevention and care are integrated within health and human service settings, including HIV/AIDS organisations and drug treatment programmes. Other measures that support comprehensive HCV services for IDUs include reimbursement, clinical guidelines, training and HCV prevention education. Community and provider collaborations inform programme and policy development. IDUs access 5 million syringes annually through harm reduction/syringe exchange programmes (SEPs) and a statewide syringe access programme. Declines in HCV prevalence amongst IDUs in New York City coincided with improved syringe availability. New models of care successfully link IDUs at SEPs and in drug treatment to health care. Over 7000 Medicaid recipients with HCV/HIV co-infection had health care encounters related to their HCV in a 12-month period and 10,547 claims for HCV-related medications were paid. The success rate of transitional case management referrals to drug treatment is over 90%. Training and clinical guidelines promote provider knowledge about HCV and contribute to quality HCV care for IDUs. Chart reviews of 2570 patients with HIV in 2004 documented HCV status 97.4% of the time, overall, in various settings. New HCV surveillance systems are operational. Despite this progress, significant challenges remain. A comprehensive, public health approach, using multiple strategies across systems and mobilizing multiple sectors, can enhance IDUs access to HCV prevention and care. A holisitic approach with integrated services, including for HCV-HIV co-infected IDUs is needed. Leadership, collaboration and resources are essential.

  8. Training Inference Making Skills Using a Situation Model Approach Improves Reading Comprehension

    Directory of Open Access Journals (Sweden)

    Lisanne eBos

    2016-02-01

    Full Text Available This study aimed to enhance third and fourth graders’ text comprehension at the situation model level. Therefore, we tested a reading strategy training developed to target inference making skills, which are widely considered to be pivotal to situation model construction. The training was grounded in contemporary literature on situation model-based inference making and addressed the source (text-based versus knowledge-based, type (necessary versus unnecessary for (re-establishing coherence, and depth of an inference (making single lexical inferences versus combining multiple lexical inferences, as well as the type of searching strategy (forward versus backward. Results indicated that, compared to a control group (n = 51, children who followed the experimental training (n = 67 improved their inference making skills supportive to situation model construction. Importantly, our training also resulted in increased levels of general reading comprehension and motivation. In sum, this study showed that a ‘level of text representation’-approach can provide a useful framework to teach inference making skills to third and fourth graders.

  9. Developing a More Comprehensive SOA Governance Framework by Using a Comparative Study Approach

    Directory of Open Access Journals (Sweden)

    Fazilat Hojaji

    2014-02-01

    Full Text Available Many companies have adopted Service-Oriented Architecture (SOA as an approach to improve agility and increase performance of system development.However, deploying SOA has been encountered to some challenges and problems including difficulties in designing effective decision structures and building a SOA roadmap, lack of service funding and lack of consistent governance processes. Therefore, to address SOA challenges, organizations require a comprehensive and applicable SOA governance framework to implement management and control mechanisms. Study of existing SOA governance frameworks reveals that these frameworks are not expressive enough to cover all important elements of SOA governance and also, the y have very little discussions and clarifications regarding underpinning structures such as SOA processes and activities, governance procedures and measurement metrics. In this paper, in the process of proposing a new SOA governance framework, a set of important elements for a desired SOA governance framework is proposed. Based on these elements, a more comprehensive and expressive framework is developed based on governance structure of COBIT. It focuses on covering SOA governance elements and resolving the shortcomings of the existing frameworks and can delivers an appropriate solution to help enable effective SOA governance.

  10. An analysis of clinical reasoning through a recent and comprehensive approach: the dual-process theory.

    Science.gov (United States)

    Pelaccia, Thierry; Tardif, Jacques; Triby, Emmanuel; Charlin, Bernard

    2011-03-14

    Clinical reasoning plays a major role in the ability of doctors to make diagnoses and decisions. It is considered as the physician's most critical competence, and has been widely studied by physicians, educationalists, psychologists and sociologists. Since the 1970s, many theories about clinical reasoning in medicine have been put forward. This paper aims at exploring a comprehensive approach: the "dual-process theory", a model developed by cognitive psychologists over the last few years. After 40 years of sometimes contradictory studies on clinical reasoning, the dual-process theory gives us many answers on how doctors think while making diagnoses and decisions. It highlights the importance of physicians' intuition and the high level of interaction between analytical and non-analytical processes. However, it has not received much attention in the medical education literature. The implications of dual-process models of reasoning in terms of medical education will be discussed.

  11. An analysis of clinical reasoning through a recent and comprehensive approach: the dual-process theory

    Directory of Open Access Journals (Sweden)

    Thierry Pelaccia

    2011-03-01

    Full Text Available Context. Clinical reasoning plays a major role in the ability of doctors to make diagnoses and decisions. It is considered as the physician's most critical competence, and has been widely studied by physicians, educationalists, psychologists and sociologists. Since the 1970s, many theories about clinical reasoning in medicine have been put forward.Purpose. This paper aims at exploring a comprehensive approach: the “dual-process theory”, a model developed by cognitive psychologists over the last few years.Discussion. After 40 years of sometimes contradictory studies on clinical reasoning, the dual-process theory gives us many answers on how doctors think while making diagnoses and decisions. It highlights the importance of physicians’ intuition and the high level of interaction between analytical and non-analytical processes. However, it has not received much attention in the medical education literature. The implications of dual-process models of reasoning in terms of medical education will be discussed.

  12. Towards a comprehensive approach for managing transitions of older workers with hearing loss.

    Science.gov (United States)

    Fok, Daniel; Shaw, Lynn; Jennings, Mary Beth; Cheesman, Margaret

    2009-01-01

    Demographic and legislative trends suggest that many older workers may remain at work past the traditional retirement age. This extended work trajectory poses new challenges and opportunities for workers with acquired hearing loss as they age. Workplaces require a new approach to enable transitions of older workers with hearing loss to remain safe and productive. A review of the literature on older workers, those with hearing loss, and strategies used to accommodate them suggests that individualized and piecemeal approaches are predominant. While universal design represents a fresh ideology that may help create more accessible and usable products and environments, its application to improve workplaces for older workers with hearing loss is limited. This paper proposes that occupational science be integrated with knowledge in hearing sciences, accessibility, and usability to assist with the transitions faced by older workers with hearing loss. A more comprehensive approach including the following three key components will be posited to examine the nexus of aging, hearing loss and work: (1) the use of an occupational perspective, along with concepts in hearing sciences to examine hearing demands and improve hearing access; (2) the use of contextual processes to promote physical and social change, and (3) the inclusion of Universal Design for Hearing (UDH) considerations as stakeholders develop more hearing friendly workplaces.

  13. Using the candidate gene approach for detecting genes underlying seed oil concentration and yield in soybean.

    Science.gov (United States)

    Eskandari, Mehrzad; Cober, Elroy R; Rajcan, Istvan

    2013-07-01

    Increasing the oil concentration in soybean seeds has been given more attention in recent years because of demand for both edible oil and biodiesel production. Oil concentration in soybean is a complex quantitative trait regulated by many genes as well as environmental conditions. To identify genes governing seed oil concentration in soybean, 16 putative candidate genes of three important gene families (GPAT: acyl-CoA:sn-glycerol-3-phosphate acyltransferase, DGAT: acyl-CoA:diacylglycerol acyltransferase, and PDAT: phospholipid:diacylglycerol acyltransferase) involved in triacylglycerol (TAG) biosynthesis pathways were selected and their sequences retrieved from the soybean database ( http://www.phytozome.net/soybean ). Three sequence mutations were discovered in either coding or noncoding regions of three DGAT soybean isoforms when comparing the parents of a 203 recombinant inbreed line (RIL) population; OAC Wallace and OAC Glencoe. The RIL population was used to study the effects of these mutations on seed oil concentration and other important agronomic and seed composition traits, including seed yield and protein concentration across three field locations in Ontario, Canada, in 2009 and 2010. An insertion/deletion (indel) mutation in the GmDGAT2B gene in OAC Wallace was significantly associated with reduced seed oil concentration across three environments and reduced seed yield at Woodstock in 2010. A mutation in the 3' untranslated (3'UTR) region of GmDGAT2C was associated with seed yield at Woodstock in 2009. A mutation in the intronic region of GmDGAR1B was associated with seed yield and protein concentration at Ottawa in 2010. The genes identified in this study had minor effects on either seed yield or oil concentration, which was in agreement with the quantitative nature of the traits. However, the novel gene-specific markers designed in the present study can be used in soybean breeding for marker-assisted selection aimed at increasing seed yield and oil

  14. The Effect of Screen Size on Mobile Phone User Comprehension of Health Information and Application Structure: An Experimental Approach.

    Science.gov (United States)

    Al Ghamdi, Ebtisam; Yunus, Faisal; Da'ar, Omar; El-Metwally, Ashraf; Khalifa, Mohamed; Aldossari, Bakheet; Househ, Mowafa

    2016-01-01

    This research analyzes the impact of mobile phone screen size on user comprehension of health information and application structure. Applying experimental approach, we asked randomly selected users to read content and conduct tasks on a commonly used diabetes mobile application using three different mobile phone screen sizes. We timed and tracked a number of parameters, including correctness, effectiveness of completing tasks, content ease of reading, clarity of information organization, and comprehension. The impact of screen size on user comprehension/retention, clarity of information organization, and reading time were mixed. It is assumed on first glance that mobile screen size would affect all qualities of information reading and comprehension, including clarity of displayed information organization, reading time and user comprehension/retention of displayed information, but actually the screen size, in this experimental research, did not have significant impact on user comprehension/retention of the content or on understanding the application structure. However, it did have significant impact on clarity of information organization and reading time. Participants with larger screen size took shorter time reading the content with a significant difference in the ease of reading. While there was no significant difference in the comprehension of information or the application structures, there were a higher task completion rate and a lower number of errors with the bigger screen size. Screen size does not directly affect user comprehension of health information. However, it does affect clarity of information organization, reading time and user's ability to recall information.

  15. Process-outcome interrelationship and standard setting in medical education: the need for a comprehensive approach.

    Science.gov (United States)

    Christensen, Leif; Karle, Hans; Nystrup, Jørgen

    2007-09-01

    An outcome-based approach to medical education compared to a process/content orientation is currently being discussed intensively. In this article, the process and outcome interrelationship in medical education is discussed, with specific emphasis on the relation to the definition of standards in basic medical education. Perceptions of outcome have always been an integrated element of curricular planning. The present debate underlines the need for stronger focus on learning objectives and outcome assessment in many medical schools around the world. The need to maintain an integrated approach of process/content and outcome is underlined in this paper. A worry is expressed about the taxonomy of learning in pure outcome-based medical education, in which student assessment can be a major determinant for the learning process, leaving the control of the medical curriculum to medical examiners. Moreover, curricula which favour reductionism by stating everything in terms of instrumental outcomes or competences, do face a risk of lowering quality and do become a prey for political interference. Standards based on outcome alone rise unclarified problems in relationship to licensure requirements of medical doctors. It is argued that the alleged dichotomy between process/content and outcome seems artificial, and that formulation of standards in medical education must follow a comprehensive line in curricular planning.

  16. Comprehensive assessment of energy systems: approach and current results of the Swiss activities

    International Nuclear Information System (INIS)

    Hirschberg, S.; Dones, R.; Kypreos, S.

    1994-01-01

    This paper provides an overview of the approaches used and results obtained to this date within the Swiss Project GaBE on ''Comprehensive Assessment of Energy Systems''. Based on the ''cradle to grave'' approach detailed environmental inventories for major fuel cycles have been generated. In comparison to earlier studies a very broad spectrum of resources and air and water pollutants has been covered. Also non-energetic resources such as land depreciation have been considered. Numerous examples of evaluations are provided in the paper, including comparisons of greenhouse gas emissions, land use, radiation and wastes, and illustrating the impact of consideration of full energy chains. In the part concerning severe accidents some evaluations based on the database established as the Paul Scherrer Institute are presented as well as the estimated contribution of hypothetical severe accidents to the external costs associated with a specific Swiss nuclear power plant. Results of applications of the large scale energy-economy model MARKAL to the Swiss energy system and greenhouse gas scenarios are described. This includes cost-optimal contributions of different technologies to reduce CO 2 emissions, and trade-offs on the national and international level. Finally, the content of other GaBE activities either being in progress or planned is provided. (orig.)

  17. The Forecasting Power of the Yield Curve, a Supervised Factor Model Approach

    DEFF Research Database (Denmark)

    Boldrini, Lorenzo; Hillebrand, Eric Tobias

    loadings have the Nelson and Siegel (1987) structure and we consider one forecast target at a time. We compare the forecasting performance of our specification to benchmark models such as principal components regression, partial least squares, and ARMA(p,q) processes. We use the yield curve data from G...

  18. New approach for regional crop yield gap analysis in the Borujen ...

    African Journals Online (AJOL)

    In general, simulated results matched well with the measured parameters in the calibration procedure. Calibrated results of WOFOST model are linked to a geographic information system, in order, to get easier their presentation and also to contribute to identification of hotspots for interventions aimed at yield improvements.

  19. Genetic, Genomic, and Breeding Approaches to Further Explore Kernel Composition Traits and Grain Yield in Maize

    Science.gov (United States)

    Da Silva, Helena Sofia Pereira

    2009-01-01

    Maize ("Zea mays L.") is a model species well suited for the dissection of complex traits which are often of commercial value. The purpose of this research was to gain a deeper understanding of the genetic control of maize kernel composition traits starch, protein, and oil concentration, and also kernel weight and grain yield. Germplasm with…

  20. A comprehensive approach to identifying repurposed drugs to treat SCN8A epilepsy.

    Science.gov (United States)

    Atkin, Talia A; Maher, Chani M; Gerlach, Aaron C; Gay, Bryant C; Antonio, Brett M; Santos, Sonia C; Padilla, Karen M; Rader, JulieAnn; Krafte, Douglas S; Fox, Matthew A; Stewart, Gregory R; Petrovski, Slavé; Devinsky, Orrin; Might, Matthew; Petrou, Steven; Goldstein, David B

    2018-04-01

    Many previous studies of drug repurposing have relied on literature review followed by evaluation of a limited number of candidate compounds. Here, we demonstrate the feasibility of a more comprehensive approach using high-throughput screening to identify inhibitors of a gain-of-function mutation in the SCN8A gene associated with severe pediatric epilepsy. We developed cellular models expressing wild-type or an R1872Q mutation in the Na v 1.6 sodium channel encoded by SCN8A. Voltage clamp experiments in HEK-293 cells expressing the SCN8A R1872Q mutation demonstrated a leftward shift in sodium channel activation as well as delayed inactivation; both changes are consistent with a gain-of-function mutation. We next developed a fluorescence-based, sodium flux assay and used it to assess an extensive library of approved drugs, including a panel of antiepileptic drugs, for inhibitory activity in the mutated cell line. Lead candidates were evaluated in follow-on studies to generate concentration-response curves for inhibiting sodium influx. Select compounds of clinical interest were evaluated by electrophysiology to further characterize drug effects on wild-type and mutant sodium channel functions. The screen identified 90 drugs that significantly inhibited sodium influx in the R1872Q cell line. Four drugs of potential clinical interest-amitriptyline, carvedilol, nilvadipine, and carbamazepine-were further investigated and demonstrated concentration-dependent inhibition of sodium channel currents. A comprehensive drug repurposing screen identified potential new candidates for the treatment of epilepsy caused by the R1872Q mutation in the SCN8A gene. Wiley Periodicals, Inc. © 2018 International League Against Epilepsy.

  1. A Comprehensive Approach to Evaluating Hazards of Microplastics in the Marine Environment

    Science.gov (United States)

    Noble, A. E.; Lewis, A. S.; Butler, C. H.; Lunsman, T. D.; Verslycke, T.

    2016-02-01

    Plastic debris in the environment is a growing global concern, and the past decade has brought particular attention to a small size range of plastic debris, often referred to as microplastics. The potential environmental effects of microplastics are complex and, as yet, poorly understood. Emerging research suggests that specific plastic types pose environmental risks primarily via indirect toxicity caused by hazardous compounds associated with microplastics (e.g., monomers, additives, and sorbed environmental pollutants). However, our understanding of the physicochemical properties that determine the environmental fate and toxicity of microplastics is limited. Some recent regulatory initiatives have been broad, seeking to regulate all solid synthetic polymers ≤5 mm despite the lack of a sound technical basis for using solely a size-based cutoff. Such broad regulation of all solid synthetic polymers may actually discourage the use and innovation of less hazardous synthetic polymers and "greener" substitutes. We propose a polymer-specific approach to evaluating potential hazards of microplastics, informed by the state of the science and current research needs. This approach relies on identifying focused tests and analyses to set criteria for determining the degree to which a solid synthetic polymer is likely to pose environmental risk. Important considerations include degradation, sorptive capacity, and monomer/additive content. Our approach is a first step toward a more comprehensive way to evaluate the environmental hazards and risks of microplastics. Our goals are to develop clearer criteria to assess future solid synthetic polymers of unknown concern, inform microplastics regulation, and drive innovation of greener solutions to this global concern.

  2. An FSPM approach for modeling fruit yield and quality in mango trees

    OpenAIRE

    Boudon , Frédéric; Persello , Severine; Jestin , Alexandra; Briand , Anne-Sarah; Fernique , Pierre; Guédon , Yann; Léchaudel , Mathieu; Grechi , Isabelle; Normand , Frédéric

    2016-01-01

    International audience; Research focus-Mango (Mangifera indica L.), the fifth most cultivated fruit in the world, is mainly produced in tropical and subtropical regions. Its cultivation raises a number of issues: (i) mango yield is irregular across years, (ii) phenological asynchronisms within and between trees maintain long periods with phenological stages susceptible to pests and diseases, and (iii) fruit quality and maturity are heterogeneous at harvest. To address these issues, we develop...

  3. Breeding high yielding, high protein spring wheats: Problems, progress and approaches to further advances

    International Nuclear Information System (INIS)

    Konzak, C.F.; Rubenthaler, G.L.

    1984-01-01

    Preliminary data offer promise that advances have been made in breeding hard red spring wheat selections with a yielding capacity about equal to current cultivars and with an increased capacity for producing high protein grain. The most promising new selections are derivatives of Magnif 41M1, CI17689, a semi-dwarf mutant of an Argentinian high protein cultivar. Rapid changes in disease and pest problems also required immediate attention and a reorientation of breeding materials and goals. Selection procedures suggested as promising include early generation (F 2 and F 3 ) screening for disease resistance and agronomic type, with screening for protein content delayed until F 4 or F 5 . Cultural conditions conducive for expressing the highest yield capacity are proposed as optimum for identifying those selections also able to produce high protein grain. A goal of routine production of 14.5% (or higher) protein grain is considered necessary and achievable under fertility management conditions required for maximum yield expression of agronomically competitive cultivars. Agronomically improved sources of high protein genes, an increasing number of induced high protein mutants, and numerous high protein crossbred derivatives of T. dicoccoides and Aegilops species have recently become available. These new or improved germplasm sources as well as a considerable reserve of yet untapped germplasm variability in other accessions of wild T. dicoccoides offer increased optimism that further, rapid advances in the breeding of adapted high yielding, high protein wheats are achievable. Improved breeding schemes, using induced male sterility mutants either to aid in crossing or to develop male sterile facilitated recurrent selection (MSFRS) populations, should contribute towards an earlier achievement of the desired goal while providing the basis for buffering against rapid changes in disease and pest problems

  4. Multi-approach assessment of the spatial distribution of the specific yield: application to the Crau plain aquifer, France

    Science.gov (United States)

    Seraphin, Pierre; Gonçalvès, Julio; Vallet-Coulomb, Christine; Champollion, Cédric

    2018-03-01

    Spatially distributed values of the specific yield, a fundamental parameter for transient groundwater mass balance calculations, were obtained by means of three independent methods for the Crau plain, France. In contrast to its traditional use to assess recharge based on a given specific yield, the water-table fluctuation (WTF) method, applied using major recharging events, gave a first set of reference values. Then, large infiltration processes recorded by monitored boreholes and caused by major precipitation events were interpreted in terms of specific yield by means of a one-dimensional vertical numerical model solving Richards' equations within the unsaturated zone. Finally, two gravity field campaigns, at low and high piezometric levels, were carried out to assess the groundwater mass variation and thus alternative specific yield values. The range obtained by the WTF method for this aquifer made of alluvial detrital material was 2.9- 26%, in line with the scarce data available so far. The average spatial value of specific yield by the WTF method (9.1%) is consistent with the aquifer scale value from the hydro-gravimetric approach. In this investigation, an estimate of the hitherto unknown spatial distribution of the specific yield over the Crau plain was obtained using the most reliable method (the WTF method). A groundwater mass balance calculation over the domain using this distribution yielded similar results to an independent quantification based on a stable isotope-mixing model. This agreement reinforces the relevance of such estimates, which can be used to build a more accurate transient hydrogeological model.

  5. New approach to increasing rice lodging resistance and biomass yield through the use of high gibberellin producing varieties.

    Directory of Open Access Journals (Sweden)

    Ayako Okuno

    Full Text Available Traditional breeding for high-yielding rice has been dependent on the widespread use of fertilizers and the cultivation of gibberellin (GA-deficient semi-dwarf varieties. The use of semi-dwarf plants facilitates high grain yield since these varieties possess high levels of lodging resistance, and thus could support the high grain weight. Although this approach has been successful in increasing grain yield, it is desirable to further improve grain production and also to breed for high biomass. In this study, we re-examined the effect of GA on rice lodging resistance and biomass yield using several GA-deficient mutants (e.g. having defects in the biosynthesis or perception of GA, and high-GA producing line or mutant. GA-deficient mutants displayed improved bending-type lodging resistance due to their short stature; however they showed reduced breaking-type lodging resistance and reduced total biomass. In plants producing high amounts of GA, the bending-type lodging resistance was inferior to the original cultivars. The breaking-type lodging resistance was improved due to increased lignin accumulation and/or larger culm diameters. Further, these lines had an increase in total biomass weight. These results show that the use of rice cultivars producing high levels of GA would be a novel approach to create higher lodging resistance and biomass.

  6. New approach to increasing rice lodging resistance and biomass yield through the use of high gibberellin producing varieties.

    Science.gov (United States)

    Okuno, Ayako; Hirano, Ko; Asano, Kenji; Takase, Wakana; Masuda, Reiko; Morinaka, Yoichi; Ueguchi-Tanaka, Miyako; Kitano, Hidemi; Matsuoka, Makoto

    2014-01-01

    Traditional breeding for high-yielding rice has been dependent on the widespread use of fertilizers and the cultivation of gibberellin (GA)-deficient semi-dwarf varieties. The use of semi-dwarf plants facilitates high grain yield since these varieties possess high levels of lodging resistance, and thus could support the high grain weight. Although this approach has been successful in increasing grain yield, it is desirable to further improve grain production and also to breed for high biomass. In this study, we re-examined the effect of GA on rice lodging resistance and biomass yield using several GA-deficient mutants (e.g. having defects in the biosynthesis or perception of GA), and high-GA producing line or mutant. GA-deficient mutants displayed improved bending-type lodging resistance due to their short stature; however they showed reduced breaking-type lodging resistance and reduced total biomass. In plants producing high amounts of GA, the bending-type lodging resistance was inferior to the original cultivars. The breaking-type lodging resistance was improved due to increased lignin accumulation and/or larger culm diameters. Further, these lines had an increase in total biomass weight. These results show that the use of rice cultivars producing high levels of GA would be a novel approach to create higher lodging resistance and biomass.

  7. An Approach to a Comprehensive Test Framework for Analysis and Evaluation of Text Line Segmentation Algorithms

    Directory of Open Access Journals (Sweden)

    Zoran N. Milivojevic

    2011-09-01

    Full Text Available The paper introduces a testing framework for the evaluation and validation of text line segmentation algorithms. Text line segmentation represents the key action for correct optical character recognition. Many of the tests for the evaluation of text line segmentation algorithms deal with text databases as reference templates. Because of the mismatch, the reliable testing framework is required. Hence, a new approach to a comprehensive experimental framework for the evaluation of text line segmentation algorithms is proposed. It consists of synthetic multi-like text samples and real handwritten text as well. Although the tests are mutually independent, the results are cross-linked. The proposed method can be used for different types of scripts and languages. Furthermore, two different procedures for the evaluation of algorithm efficiency based on the obtained error type classification are proposed. The first is based on the segmentation line error description, while the second one incorporates well-known signal detection theory. Each of them has different capabilities and convenience, but they can be used as supplements to make the evaluation process efficient. Overall the proposed procedure based on the segmentation line error description has some advantages, characterized by five measures that describe measurement procedures.

  8. Comprehensive model of annual plankton succession based on the whole-plankton time series approach.

    Directory of Open Access Journals (Sweden)

    Jean-Baptiste Romagnan

    Full Text Available Ecological succession provides a widely accepted description of seasonal changes in phytoplankton and mesozooplankton assemblages in the natural environment, but concurrent changes in smaller (i.e. microbes and larger (i.e. macroplankton organisms are not included in the model because plankton ranging from bacteria to jellies are seldom sampled and analyzed simultaneously. Here we studied, for the first time in the aquatic literature, the succession of marine plankton in the whole-plankton assemblage that spanned 5 orders of magnitude in size from microbes to macroplankton predators (not including fish or fish larvae, for which no consistent data were available. Samples were collected in the northwestern Mediterranean Sea (Bay of Villefranche weekly during 10 months. Simultaneously collected samples were analyzed by flow cytometry, inverse microscopy, FlowCam, and ZooScan. The whole-plankton assemblage underwent sharp reorganizations that corresponded to bottom-up events of vertical mixing in the water-column, and its development was top-down controlled by large gelatinous filter feeders and predators. Based on the results provided by our novel whole-plankton assemblage approach, we propose a new comprehensive conceptual model of the annual plankton succession (i.e. whole plankton model characterized by both stepwise stacking of four broad trophic communities from early spring through summer, which is a new concept, and progressive replacement of ecological plankton categories within the different trophic communities, as recognised traditionally.

  9. PRISM offers a comprehensive genomic approach to transcription factor function prediction

    KAUST Repository

    Wenger, A. M.; Clarke, S. L.; Guturu, H.; Chen, J.; Schaar, B. T.; McLean, C. Y.; Bejerano, G.

    2013-01-01

    The human genome encodes 1500-2000 different transcription factors (TFs). ChIP-seq is revealing the global binding profiles of a fraction of TFs in a fraction of their biological contexts. These data show that the majority of TFs bind directly next to a large number of context-relevant target genes, that most binding is distal, and that binding is context specific. Because of the effort and cost involved, ChIP-seq is seldom used in search of novel TF function. Such exploration is instead done using expression perturbation and genetic screens. Here we propose a comprehensive computational framework for transcription factor function prediction. We curate 332 high-quality nonredundant TF binding motifs that represent all major DNA binding domains, and improve cross-species conserved binding site prediction to obtain 3.3 million conserved, mostly distal, binding site predictions. We combine these with 2.4 million facts about all human and mouse gene functions, in a novel statistical framework, in search of enrichments of particular motifs next to groups of target genes of particular functions. Rigorous parameter tuning and a harsh null are used to minimize false positives. Our novel PRISM (predicting regulatory information from single motifs) approach obtains 2543 TF function predictions in a large variety of contexts, at a false discovery rate of 16%. The predictions are highly enriched for validated TF roles, and 45 of 67 (67%) tested binding site regions in five different contexts act as enhancers in functionally matched cells.

  10. INTERTEXTUALITY AND COHERENCE IN A CHRONICLE OF JOÃO UBALDO RIBEIRO: APPROACHES IN READING COMPREHENSION

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Pasero

    2016-12-01

    Full Text Available The purpose of this paper is to discuss, from an educational point of view, taking as a starting point the analysis of a literary chronicle of an argumentative character in the Portuguese language in its Brazilian variant, the parameters of textuality (BEAUGRANDE; DRESSLER, 1997 as access roads into the text that contribute to the construction of meaning, and the use of some mechanisms of textualization (BRONCKART, 1996, DUARTE, 2003. With few textual organizers or connectors, the coherence (thematic and pragmatic of the chronicle analyzed (“Questões gramaticais”, by João Ubaldo Ribeiro is determined by the shape of the text and its thematic unity, which is generated by a critical discourse based on intertextual and intergender marks which appeal, from a pragmatic consideration, to the encyclopedia of the reader. The objective is to contribute, in the field of the Portuguese language teaching in its mode of reading comprehension, to the development of interactive tasks that allow a dynamic and contextualized approach to the text from the alluded perspective, based on the resources available in the electronic media.

  11. CEOS Theory: A Comprehensive Approach to Understanding Hard to Maintain Behaviour Change.

    Science.gov (United States)

    Borland, Ron

    2017-03-01

    This paper provides a brief introduction to CEOS theory, a comprehensive theory for understanding hard to maintain behaviour change. The name CEOS is an acronym for Context, Executive, and Operational Systems theory. Behaviour is theorised to be the result of the moment by moment interaction between internal needs (operational processes) in relation to environmental conditions, and for humans this is augmented by goal-directed, executive action which can transcend immediate contingencies. All behaviour is generated by operational processes. Goal-directed behaviours only triumph over contingency-generated competing behaviours when operational processes have been sufficiently activated to support them. Affective force can be generated around executive system (ES) goals from such things as memories of direct experience, vicarious experience, and emotionally charged communications mediated through stories the person generates. This paper makes some refinements and elaborations of the theory, particularly around the role of feelings, and of the importance of stories and scripts for facilitating executive action. It also sketches out how it reconceptualises a range of issues relevant to behaviour change. CEOS provides a framework for understanding the limitations of both informational and environmental approaches to behaviour change, the need for self-regulatory strategies and for taking into account more basic aspects of human functioning. © 2016 The Authors. Applied Psychology: Health and Well-Being published by John Wiley & Sons Ltd on behalf of International Association of Applied Psychology.

  12. PRISM offers a comprehensive genomic approach to transcription factor function prediction

    KAUST Repository

    Wenger, A. M.

    2013-02-04

    The human genome encodes 1500-2000 different transcription factors (TFs). ChIP-seq is revealing the global binding profiles of a fraction of TFs in a fraction of their biological contexts. These data show that the majority of TFs bind directly next to a large number of context-relevant target genes, that most binding is distal, and that binding is context specific. Because of the effort and cost involved, ChIP-seq is seldom used in search of novel TF function. Such exploration is instead done using expression perturbation and genetic screens. Here we propose a comprehensive computational framework for transcription factor function prediction. We curate 332 high-quality nonredundant TF binding motifs that represent all major DNA binding domains, and improve cross-species conserved binding site prediction to obtain 3.3 million conserved, mostly distal, binding site predictions. We combine these with 2.4 million facts about all human and mouse gene functions, in a novel statistical framework, in search of enrichments of particular motifs next to groups of target genes of particular functions. Rigorous parameter tuning and a harsh null are used to minimize false positives. Our novel PRISM (predicting regulatory information from single motifs) approach obtains 2543 TF function predictions in a large variety of contexts, at a false discovery rate of 16%. The predictions are highly enriched for validated TF roles, and 45 of 67 (67%) tested binding site regions in five different contexts act as enhancers in functionally matched cells.

  13. Final report on the comprehensive approach to energy conservation for the Aboriginal community in Ontario

    Energy Technology Data Exchange (ETDEWEB)

    Fox, C.D. [Fort William First Nation, Thunder Bay, ON (Canada)

    2006-03-13

    This report presented a comprehensive approach to energy conservation programming for the Fort William First Nation, located in Thunder Bay, Ontario. The report outlined the historical context of the relationship between the Canadian government and Aboriginal people. The Aboriginal community in Ontario was described with reference to the difference between First Nations population, Metis, and Inuit. Statistics on the Aboriginal population in Ontario was broken down. Different Aboriginal organizations as well as organizations serving Aboriginal peoples were identified and described. The report also described the political process and administrative protocol for energy conservation and energy efficiency. Energy conservation in the Aboriginal community was also explained. Last, the report provided several recommendations related to awareness and education; translation; incentives; delivery mechanisms; and pilot projects. The report concluded with an agreement to hold a provincial conference in Toronto on the issues raised in the report. The report concluded that an Aboriginal unit within the Bureau of Conservation of the Ontario Power Authority was envisioned to plan, develop, implement, manage and monitor the deliverables resulting from the report.

  14. A Comprehensive Approach to Post-Conflict Reconstruction: German Experience in Afghanistan

    Directory of Open Access Journals (Sweden)

    Philip Olegovich Trunov

    2016-12-01

    Full Text Available As a part of a larger research project on complex linkages between security and development implemented by the Center for Security and Development Studies at the Lomonosov Moscow State University, this paper examines the complex dilemmas of pursuing comprehensive approach to post-conflict reconstruction with an example of Federal Republic of Germany’s experience with the Provincial Reconstruction Teams (PRTs in Afghanistan after the terrorist attacks of 9/11. The first section depicts the background of deployment of the PRTs on Afghan territory. The second section compares the U.S., British and German models of PRTs and assesses the role of those teams as vehicles of close civil-military, interagency coordination. The third and the fourth sections identify respectively characteristic features of the German PRTs’ activities in Kunduz and Badakhshan provinces and the main obstacles that hindered the achievement of key objectives. The conclusion contains a concise assessment of effectiveness and efficiency of PRTs as a mechanism of addressing complex challenges of post-conflict reconstruction and transition to peaceful development. It also postulates that the PRT model, regardless of some objective difficulties faced by various German agencies, may be very relevant in the future in fulfilling a revised agenda of the German foreign and defense policies in the XXI century.

  15. A comprehensive WSN-based approach to efficiently manage a Smart Grid.

    Science.gov (United States)

    Martinez-Sandoval, Ruben; Garcia-Sanchez, Antonio-Javier; Garcia-Sanchez, Felipe; Garcia-Haro, Joan; Flynn, David

    2014-10-10

    The Smart Grid (SG) is conceived as the evolution of the current electrical grid representing a big leap in terms of efficiency, reliability and flexibility compared to today's electrical network. To achieve this goal, the Wireless Sensor Networks (WSNs) are considered by the scientific/engineering community to be one of the most suitable technologies to apply SG technology to due to their low-cost, collaborative and long-standing nature. However, the SG has posed significant challenges to utility operators-mainly very harsh radio propagation conditions and the lack of appropriate systems to empower WSN devices-making most of the commercial widespread solutions inadequate. In this context, and as a main contribution, we have designed a comprehensive ad-hoc WSN-based solution for the Smart Grid (SENSED-SG) that focuses on specific implementations of the MAC, the network and the application layers to attain maximum performance and to successfully deal with any arising hurdles. Our approach has been exhaustively evaluated by computer simulations and mathematical analysis, as well as validation within real test-beds deployed in controlled environments. In particular, these test-beds cover two of the main scenarios found in a SG; on one hand, an indoor electrical substation environment, implemented in a High Voltage AC/DC laboratory, and, on the other hand, an outdoor case, deployed in the Transmission and Distribution segment of a power grid. The results obtained show that SENSED-SG performs better and is more suitable for the Smart Grid than the popular ZigBee WSN approach.

  16. Respiratory consequences of prematurity: evolution of a diagnosis and development of a comprehensive approach.

    Science.gov (United States)

    Maitre, Nathalie L; Ballard, Roberta A; Ellenberg, Jonas H; Davis, Stephanie D; Greenberg, James M; Hamvas, Aaron; Pryhuber, Gloria S

    2015-05-01

    Bronchopulmonary dysplasia (BPD) is the most common respiratory consequence of premature birth and contributes to significant short- and long-term morbidity, mortality and resource utilization. Initially defined as a radiographic, clinical and histopathological entity, the chronic lung disease known as BPD has evolved as obstetrical and neonatal care have improved the survival of lower gestational age infants. Now, definitions based on the need for supplementary oxygen at 28 days and/or 36 weeks provide a useful reference point in the neonatal intensive-care unit (NICU), but are no longer based on histopathological findings, and are neither designed to predict longer term respiratory consequences nor to study the evolution of a multifactorial disease. The aims of this review are to critically examine the evolution of the diagnosis of BPD and the challenges inherent to current classifications. We found that the increasing use of respiratory support strategies that administer ambient air without supplementary oxygen confounds oxygen-based definitions of BPD. Furthermore, lack of reproducible, genetic, biochemical and physiological biomarkers limits the ability to identify an impending BPD for early intervention, quantify disease severity for standardized classification and approaches and reliably predict the long-term outcomes. More comprehensive, multidisciplinary approaches to overcome these challenges involve longitudinal observation of extremely preterm infants, not only those with BPD, using genetic, environmental, physiological and clinical data as well as large databases of patient samples. The Prematurity and Respiratory Outcomes Program (PROP) will provide such a framework to address these challenges through high-resolution characterization of both NICU and post-NICU discharge outcomes.

  17. A simple theoretical approach to determine relative ion yield (RIY) in glow discharge mass spectrometry (GDMS)

    Energy Technology Data Exchange (ETDEWEB)

    Born, Sabine [Degussa AG, Hanau (Germany); Matsunami, Noriaki [Nagoya Univ. (Japan). Faculty of Engineering; Tawara, Hiroyuki [National Inst. for Fusion Science, Toki, Gifu (Japan)

    2000-01-01

    Direct current glow discharge mass spectrometry (dc-GDMS) has been applied to detect impurities in metals. The aim of this study is to understand quantitatively the processes taking place in GDMS and establish a model to calculate the relative ion yield (RIY), which is inversely proportional to the relative sensitivity factor (RSF), in order to achieve better agreement between the calculated and the experimental RIYs. A comparison is made between the calculated RIY of the present model and the experimental RIY, and also with other models. (author)

  18. An approach to define the effective lath size controlling yield strength of bainite

    International Nuclear Information System (INIS)

    Zhu Kangying; Bouaziz, Olivier; Oberbillig, Carla; Huang, Mingxin

    2010-01-01

    Research highlights: In this study, we developed a series of fully bainitic microstructures with negligible carbide precipitation in ultra-low carbon steels. Then, we investigated the microstructure by EBSD as well as their mechanical properties. It is found that the yield stress of such bainite is proportional to the inverse lath size defined with low boundary misorientation (2-7 deg.). We explained this by employing a theory which predicts the flow stress of deformed metals, assuming that both lath boundary and dislocation cell boundary have similar capability of being dislocation obstacles. - Abstract: A fully bainitic microstructure with negligible carbide precipitation is obtained in two ultra-low carbon steels. The size and misorientation of bainite laths are analysed by Electron Back Scattering Diffraction (EBSD). It is found that the yield stress of bainite is proportional to the inverse lath size defined with low boundary misorientation (2-7 deg.). This can be explained by a theory predicting the flow stress of deformed metals, assuming that both lath boundary and dislocation cell boundary have similar capability of being dislocation obstacles.

  19. Pulsed magnetic field: a contemporary approach offers to enhance plant growth and yield of soybean.

    Science.gov (United States)

    Radhakrishnan, Ramalingam; Ranjitha Kumari, Bollipo Diana

    2012-02-01

    The possible involvement of pulsed magnetic field (PMF) pretreatment in development and yield of soybean was investigated. Seeds were subjected to 20 days with 1500 nT at 10.0 Hz of PMF for 5 h per day. PMF pretreatment increased the plant height, fresh and dry weight, and protein content with the changes of protein profile in 8 days old seedlings. In addition, activity of enzymes such as β-amylase, acid phosphatase, polyphenol oxidase and catalase was enhanced while α-amylase, alkaline phosphatase, protease and nitrate reductase activities declined due to PMF exposure. However, a considerable increment of Fe, Cu, Mn, Zn, Mg, K and Na contents with reduced level of Ca was found in PMF treated seedlings. The number of leaves, pods, seeds and length of pods, and weight of seeds were also remarkably higher in PMF treatment in contrast to controls. The results suggest that pretreatment of PMF plays important roles in improvement of crop productivity of soybean through the enhancement of protein, mineral accumulation and enzyme activities which leads to increase the growth and yield. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

  20. Determinants of Success in Native and Non-Native Listening Comprehension: An Individual Differences Approach

    Science.gov (United States)

    Andringa, Sible; Olsthoorn, Nomi; van Beuningen, Catherine; Schoonen, Rob; Hulstijn, Jan

    2012-01-01

    The goal of this study was to explain individual differences in both native and non-native listening comprehension; 121 native and 113 non-native speakers of Dutch were tested on various linguistic and nonlinguistic cognitive skills thought to underlie listening comprehension. Structural equation modeling was used to identify the predictors of…

  1. Determinants of success in native and non-native listening comprehension: an individual differences approach

    NARCIS (Netherlands)

    Andringa, S.; Olsthoorn, N.; van Beuningen, C.; Schoonen, R.; Hulstijn, J.

    2012-01-01

    The goal of this study was to explain individual differences in both native and non-native listening comprehension; 121 native and 113 non-native speakers of Dutch were tested on various linguistic and nonlinguistic cognitive skills thought to underlie listening comprehension. Structural equation

  2. A Media Literacy Education Approach to Teaching Adolescents Comprehensive Sexual Health Education

    Science.gov (United States)

    Scull, Tracy Marie; Malik, Christina V.; Kupersmidt, Janis Beth

    2014-01-01

    As states are moving toward comprehensive sexual health education, educators require engaging and effective curricula. This pre-post study (N = 64) examined the feasibility of a comprehensive, media literacy education program for influencing adolescents' sexual health and media literacy outcomes. After the program, participants were more likely to…

  3. A Comparative Study of the Effects of Two Approaches of Dynamic Assessment on the Reading Comprehension of Iranian EFL Learners

    Directory of Open Access Journals (Sweden)

    Jila Naeini

    2015-03-01

    Full Text Available The aim of this study was to examine and compare the impact of two Dynamic Assessment (DA approaches, that is, Feuerstein’s Mediated Learning Experience (MLE and Brown’s Graduated Prompt (GP on Iranian EFL learners’ reading comprehension. Therefore, a mixed methods approach consisting of a semi-structured interview, a pretest, an intervention program, a posttest, and a transfer test was applied to assess and compare the efficacy of two DA approaches. One hundred and two EFL learners taking a General English course at Islamic Azad University were assigned to two experimental groups (MLEG and GPG and one comparison group (CG. The participants in the MLEG took part in the MLE, and the participants in the GPG participated in the GP intervention program.  The results of the qualitative as well as the aggregate and disaggregated quantitative data analyses indicated that both intervention approaches of DA were effective in enhancing the learners’ reading comprehension.

  4. A network-based approach for semi-quantitative knowledge mining and its application to yield variability

    Science.gov (United States)

    Schauberger, Bernhard; Rolinski, Susanne; Müller, Christoph

    2016-12-01

    Variability of crop yields is detrimental for food security. Under climate change its amplitude is likely to increase, thus it is essential to understand the underlying causes and mechanisms. Crop models are the primary tool to project future changes in crop yields under climate change. A systematic overview of drivers and mechanisms of crop yield variability (YV) can thus inform crop model development and facilitate improved understanding of climate change impacts on crop yields. Yet there is a vast body of literature on crop physiology and YV, which makes a prioritization of mechanisms for implementation in models challenging. Therefore this paper takes on a novel approach to systematically mine and organize existing knowledge from the literature. The aim is to identify important mechanisms lacking in models, which can help to set priorities in model improvement. We structure knowledge from the literature in a semi-quantitative network. This network consists of complex interactions between growing conditions, plant physiology and crop yield. We utilize the resulting network structure to assign relative importance to causes of YV and related plant physiological processes. As expected, our findings confirm existing knowledge, in particular on the dominant role of temperature and precipitation, but also highlight other important drivers of YV. More importantly, our method allows for identifying the relevant physiological processes that transmit variability in growing conditions to variability in yield. We can identify explicit targets for the improvement of crop models. The network can additionally guide model development by outlining complex interactions between processes and by easily retrieving quantitative information for each of the 350 interactions. We show the validity of our network method as a structured, consistent and scalable dictionary of literature. The method can easily be applied to many other research fields.

  5. Facilitating programming comprehension for novice learners with multimedia approach: A preliminary investigation

    Science.gov (United States)

    Annamalai, Subashini; Salam, Sobihatun Nur Abdul

    2017-10-01

    This research paper presents the preliminary investigation on the use of an interactive multimedia courseware named MAFPro, to facilitate C Programming lessons for novice learners. The courseware utilizes the elements of multimedia that focus on enhancing learners' programming comprehension. Among the aspects that were examined were the students' programming comprehension and their perceived motivation of MAFPro. This study was carried out in a survey design method with the participation of 30 undergraduates who are novice learners. The data analysis indicates that the multimedia courseware, MAFPro that has been used in the C programming classroom has a significant difference on the undergraduates' programming comprehension. The students also perceived MAFPro as motivating and engaging.

  6. AREVA NP decontamination concept for decommissioning. A comprehensive approach based on over 30 years experience

    International Nuclear Information System (INIS)

    Stiepani, Christoph

    2011-01-01

    Decontamination prior to Decommissioning and Dismantlement is imperative. Not only does it provide for minimization of personnel dose exposure but also maximization of the material volume available for free release. Since easier dismantling techniques in lower dose areas can be applied, the licensing process is facilitated and the scheduling and budgeting effort is more reliable. The most internationally accepted approach for Decontamination prior to Decommissioning projects is the Full System Decontamination (FSD). FSD is defined as the chemical decontamination of the primary cooling circuit, in conjunction with the main auxiliary systems. AREVA NP has long-term experience with Full System Decontamination for return to service of operating nuclear power plants as well as for decommissioning after shutdown. Since 1976, AREVA NP has performed over 500 decontamination applications and, from 1986, Decontaminations prior to Decommissioning projects which comprise virtually all NPP designs and plant conditions were performed: NPP designs: HPWR, PWR, and BWR by AREVA, Westinghouse, ABB and GE. Decontaminations performed shortly after final shutdown or several years later, and even after re-opening Safe Enclosure. High Alpha inventory and or low gamma/alpha ratio. Main Coolant chemistry (e.g., with and without Zn injection during operation). Fifteen Decontaminations prior to Decommissioning Projects have been performed successfully to date and the sixteenth FSD is now in the detailed engineering phase and is scheduled to commence late 2010. AREVA NP has developed a fully comprehensive approach for decontamination based on the CORD® (Chemical Oxidation Reduction Decontamination) Family, applied using the in-house designed decontamination equipment AMDA TM (Automatic Modular Decontamination Appliance). Based on the vast experience of AREVA NP in the field of decontamination, the Decontamination Concept for Decommissioning was developed. This concept ensures that the

  7. Blood transfusion determines postoperative morbidity in pediatric cardiac surgery applying a comprehensive blood-sparing approach.

    Science.gov (United States)

    Redlin, Matthias; Kukucka, Marian; Boettcher, Wolfgang; Schoenfeld, Helge; Huebler, Michael; Kuppe, Hermann; Habazettl, Helmut

    2013-09-01

    Recently we suggested a comprehensive blood-sparing approach in pediatric cardiac surgery that resulted in no transfusion in 71 infants (25%), postoperative transfusion only in 68 (24%), and intraoperative transfusion in 149 (52%). We analyzed the effects of transfusion on postoperative morbidity and mortality in the same cohort of patients. The effect of transfusion on the length of mechanical ventilation and intensive care unit stay was assessed using Kaplan-Meier curves. To assess whether transfusion independently determined the length of mechanical ventilation and length of intensive care unit stay, a multivariate model was applied. Additionally, in the subgroup of transfused infants, the effect of the applied volume of packed red blood cells was assessed. The median length of mechanical ventilation was 11 hours (interquartile range, 9-18 hours), 33 hours (interquartile range, 18-80 hours), and 93 hours (interquartile range, 34-161 hours) in the no transfusion, postoperative transfusion only, and intraoperative transfusion groups, respectively (P interquartile range, 1-2 days), 3.5 days (interquartile range, 2-5 days), and 8 days (interquartile range, 3-9 days; P < .00001). The multivariate hazard ratio for early extubation was 0.24 (95% confidence interval, 0.16-0.35) and 0.37 (95% confidence interval, 0.25-0.55) for the intraoperative transfusion and postoperative transfusion only groups, respectively (P < .00001). In addition, the cardiopulmonary time, body weight, need for reoperation, and hemoglobin during cardiopulmonary bypass affected the length of mechanical ventilation. Similar results were obtained for the length of intensive care unit stay. In the subgroup of transfused infants, the volume of packed red blood cells also independently affected both the length of mechanical ventilation and the length of intensive care unit stay. The incidence and volume of blood transfusion markedly affects postoperative morbidity in pediatric cardiac surgery. These

  8. A Study of Holistic and Subskill Instructional Approaches to Reading Comprehension.

    Science.gov (United States)

    Vacca, Richard T.

    1980-01-01

    In a six-week study involving seventh- to ninth-grade students in a summer corrective reading program, neither the holistic nor the subskill treatment had a significant advantage in improving student reading comprehension or attitude toward reading. (JT)

  9. Narrowing the agronomic yield gap with improved nitrogen use efficiency: a modeling approach.

    Science.gov (United States)

    Ahrens, T D; Lobell, D B; Ortiz-Monasterio, J I; Li, Y; Matson, P A

    2010-01-01

    Improving nitrogen use efficiency (NUE) in the major cereals is critical for more sustainable nitrogen use in high-input agriculture, but our understanding of the potential for NUE improvement is limited by a paucity of reliable on-farm measurements. Limited on-farm data suggest that agronomic NUE (AE(N)) is lower and more variable than data from trials conducted at research stations, on which much of our understanding of AE(N) has been built. The purpose of this study was to determine the magnitude and causes of variability in AE(N) across an agricultural region, which we refer to as the achievement distribution of AE(N). The distribution of simulated AE(N) in 80 farmers' fields in an irrigated wheat system in the Yaqui Valley, Mexico, was compared with trials at a local research center (International Wheat and Maize Improvement Center; CIMMYT). An agroecosystem simulation model WNMM was used to understand factors controlling yield, AE(N), gaseous N emissions, and nitrate leaching in the region. Simulated AE(N) in the Yaqui Valley was highly variable, and mean on-farm AE(N) was 44% lower than trials with similar fertilization rates at CIMMYT. Variability in residual N supply was the most important factor determining simulated AE(N). Better split applications of N fertilizer led to almost a doubling of AE(N), increased profit, and reduced N pollution, and even larger improvements were possible with technologies that allow for direct measurement of soil N supply and plant N demand, such as site-specific nitrogen management.

  10. A Comprehensive Approach for the Ergonomic Evaluation of 13 Emergency and Transport Ventilators.

    Science.gov (United States)

    Marjanovic, Nicolas; L'Her, Erwan

    2016-05-01

    Mechanical ventilation is an important part of emergency medicine and is frequently used for transportation. Human errors during ventilator settings are frequent and may be associated with high morbidity/mortality. The aim of the study was to provide a complete ergonomic evaluation of emergency and transport ventilators, taking into account objective and subjective human-machine interface assessments and individual mental work load. We performed a prospective bench ergonomic evaluation of 13 emergency and transport ventilators, using standardized conditions and a global methodological approach. The study was performed in an evaluation laboratory dedicated to respiratory care, and 12 emergency physicians unfamiliar with the tested devices were included in the evaluation. The ventilators were classified into 3 categories (simple, sophisticated, and ICU-like). Objective chronometric evaluations were conducted considering 9 tasks, and subjective evaluations were performed (ease of use, willingness to use, and user-friendliness of monitoring) using Likert scales. Mental work load evaluation was performed using the NASA Task Load Index scale. Overall task failure rate represented 4% of all attempts. Setting modifications, ventilation mode changes, and powering down durations were different between simple and other emergency and transport ventilator categories (P < .005). There was no difference between ventilator categories for the ease of use and user-friendliness of the monitoring. In contrast, the willingness to use was lower for simple devices, compared with sophisticated and ICU-like emergency and transport ventilators (2.9 ± 1.4 vs 3.9 ± 1.2, P = .002 and 4.3 ± 1, P < .001). No differences were observed between devices regarding the mental work load, except for several specific devices in the sophisticated category. A comprehensive ergonomic evaluation provides valuable information while investigating operational friendliness in emergency and transport

  11. IRIS: A Comprehensive Approach to Implementing Nuclear Power in Countries with Smaller Electric Grids

    International Nuclear Information System (INIS)

    Petrovic, B.; Carelli, M. D.; Sandell, L.; Storrick, G. D.; Cavlina, N.

    2008-01-01

    Many emerging markets and smaller size countries are considering the nuclear option and the deployment of their first nuclear reactor(s). However, some of their requirements and available infrastructure are quite different from those of larger countries currently employing nuclear power. Specific considerations might include: a small size electrical grid, in some cases on the order of a few GWe; limited financial resources; no nuclear experience; inadequate availability of necessary material and people infrastructure. Large nuclear power plants of 1000 MWe or greater do not provide best fit. The IRIS (International Reactor Innovative and Secure) reactor, under development by an international team of eighteen organizations from nine countries led by Westinghouse specifically addresses these needs. IRIS is an advanced PWR with integral configuration that yields a simple design with enhanced safety. The IRIS size is 335 MWe and may be deployed in single or multiple modules. It can fit almost any grid, or a small utility within a larger grid; moreover, it allows incremental power additions as needed. The capital outlay is of the order of hundreds of millions rather than a few billions dollars. Successive construction and operation of multiple modules significantly reduces the required capital resources and capital at risk with generation income from earlier plants offsetting the construction outlays of subsequent ones. This is highly desirable in both developed and emerging markets, but it may be of critical importance to the latter. IRIS safety characteristics allow for licensing with a significantly reduced size of emergency zone, a critical feature for small countries and when cogeneration is desired. In fact, IRIS is designed to produce steam for district heating, water desalination and bio-fuel generation in addition to electricity. The U.S. Department of Energy (DOE) has announced in February 2008 its intention to contribute to funding the licensing of a 'Grid

  12. Changing by Design: A Comprehensive Approach to School Reform. [Booklet with Audiotapes].

    Science.gov (United States)

    North Central Regional Educational Lab., Oak Brook, IL.

    Comprehensive school reform (CSR) focuses on reorganizing and revitalizing entire schools, rather than on implementing individual programs. The idea behind CSR is that schools cannot educate all students to high levels unless all the education system's components work together toward a common goal. Choosing a CSR model can be difficult and…

  13. Toward a Comprehensive Model of Antisocial Development: A Dynamic Systems Approach

    Science.gov (United States)

    Granic, Isabela; Patterson, Gerald R.

    2006-01-01

    The purpose of this article is to develop a preliminary comprehensive model of antisocial development based on dynamic systems principles. The model is built on the foundations of behavioral research on coercion theory. First, the authors focus on the principles of multistability, feedback, and nonlinear causality to reconceptualize real-time…

  14. Reading Comprehension Course through a Genre-Oriented Approach at a School in Colombia

    Science.gov (United States)

    Rodríguez Sánchez, Andrés

    2017-01-01

    This paper reports on an action-research study aimed at identifying the problems and needs of a specific group of tenth graders at a school in Colombia in relation to their reading comprehension in English in order to design, partially implement, and evaluate a genre-oriented syllabus. Findings show that the explicit instruction of metacognitive…

  15. Exploring Reading Comprehension Needs of Iranian EAP Students of Health Information Management (HIM): A Triangulated Approach

    Science.gov (United States)

    Atai, Mahmood Reza; Nazari, Ogholgol

    2011-01-01

    Discipline-based English for Academic Purposes (EAP) reading programs in Iran are designed to fill the gap between the students' general English reading competence and their ability to read authentic discipline-specific texts. This study attempted to assess target and present reading comprehension needs of EAP students of Health Information…

  16. An Approach to Evaluate Comprehensive Plan and Identify Priority Lands for Future Land Use Development to Conserve More Ecological Values

    Directory of Open Access Journals (Sweden)

    Long Zhou

    2018-01-01

    Full Text Available Urbanization has significant impacts on the regional environmental quality through altering natural lands, converting them to urban built-up areas. One common strategy applied by urban planners to manage urbanization and preserve natural resources is to make a comprehensive plan and concentrate future land use in certain areas. However, in practice, planners used to make future land use planning mainly based on their subjective interpretations with limited ecological supporting evidence and analysis. Here, we propose a new approach composed of ecological modelling and land use zoning in the spatial matrix to evaluate the comprehensive plan and identify priority lands for sustainable land use planning. We use the city of Corvallis, OR, as the test bed to demonstrate this new approach. The results indicate that the Corvallis Comprehensive Plan 1998–2020 featured with compact development is not performing efficiently in conserving ecological values, and the land use plan featured with mixed-use spreading development generated by the proposed approach meets the city’s land demands for urban growth, and conserves 103% more ecological value of retaining storm water nitrogen, 270% more ecological value of retaining storm water phosphorus and 19% more ecological value in storing carbon in the whole watershed. This study indicates that if planned with scientific analysis and evidence, spreading urban development does not necessarily result in less sustainable urban environment than the compact development recommended in smart growth.

  17. A rational inference approach to group and individual-level sentence comprehension performance in aphasia.

    Science.gov (United States)

    Warren, Tessa; Dickey, Michael Walsh; Liburd, Teljer L

    2017-07-01

    The rational inference, or noisy channel, account of language comprehension predicts that comprehenders are sensitive to the probabilities of different interpretations for a given sentence and adapt as these probabilities change (Gibson, Bergen & Piantadosi, 2013). This account provides an important new perspective on aphasic sentence comprehension: aphasia may increase the likelihood of sentence distortion, leading people with aphasia (PWA) to rely more on the prior probability of an interpretation and less on the form or structure of the sentence (Gibson, Sandberg, Fedorenko, Bergen & Kiran, 2015). We report the results of a sentence-picture matching experiment that tested the predictions of the rational inference account and other current models of aphasic sentence comprehension across a variety of sentence structures. Consistent with the rational inference account, PWA showed similar sensitivity to the probability of particular kinds of form distortions as age-matched controls, yet overall their interpretations relied more on prior probability and less on sentence form. As predicted by rational inference, but not by other models of sentence comprehension in aphasia, PWA's interpretations were more faithful to the form for active and passive sentences than for direct object and prepositional object sentences. However contra rational inference, there was no evidence that individual PWA's severity of syntactic or semantic impairment predicted their sensitivity to form versus the prior probability of a sentence, as cued by semantics. These findings confirm and extend previous findings that suggest the rational inference account holds promise for explaining aphasic and neurotypical comprehension, but they also raise new challenges for the account. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. A Comprehensive Rehabilitation Approach in a Patient With Serious Neuropsychiatric Systemic Lupus Erythematosus.

    Science.gov (United States)

    Ko, Yong Jae; Lee, Yang Gyun; Park, Ji Woong; Ahn, Sung Ho; Kwak, Jin Myoung; Choi, Yoon-Hee

    2016-08-01

    Neuropsychiatric systemic lupus erythematosus (NPSLE) involves the central and peripheral nervous system in patients with systemic lupus erythematosus (SLE). It is essential to specify the problems faced by patients with NPSLE because it causes diverse disabilities and impairs quality of life. After performing a comprehensive evaluation, tailored management should be provided for the patient's specific problems. We report here the case of a 30-year-old female with SLE who experienced serious neuropsychiatric symptoms cerebral infarction followed by posterior reversible encephalopathy syndrome and peripheral polyneuropathy. We systemically assessed the patient using the International Classification of Functioning, Disability and Health model as a clinical problem-solving tool and provided comprehensive rehabilitation by focusing on her problems.

  19. Towards a comprehensive theory for He II: II. A temperature-dependent field-theoretic approach

    International Nuclear Information System (INIS)

    Chela-Flores, J.; Ghassib, H.B.

    1982-09-01

    New experimental aspects of He II are used as a guide towards a comprehensive theory in which non-zero temperature U(1) and SU(2) gauge fields are incorporated into a gauge hierarchy of effective Lagrangians. We conjecture that an SU(n) gauge-theoretic description of the superfluidity of 4 He may be obtained in the limit n→infinity. We indicate, however, how experiments may be understood in the zeroth, first and second order of the hierarchy. (author)

  20. Integrated remote sensing imagery and two-dimensional hydraulic modeling approach for impact evaluation of flood on crop yields

    Science.gov (United States)

    Chen, Huili; Liang, Zhongyao; Liu, Yong; Liang, Qiuhua; Xie, Shuguang

    2017-10-01

    , with the SCS-CN model as a rainfall-runoff generator and the two-dimensional hydraulic model implementing the routing scheme for surface runoff; and (c) The spatial combination between crop yield losses and flood dynamics on a grid scale can be used to investigate the relationship between the intensity of flood characteristics and associated loss extent. The modeling framework was applied for a 50-year return period flood that occurred in Jilin province, Northeast China, which caused large agricultural losses in August 2013. The modeling results indicated that (a) the flow velocity was the most influential factor that caused spring corn, rice and soybean yield losses from extreme storm event in the mountainous regions; (b) the power function archived the best results that fit the velocity-loss relationship for mountainous areas; and (c) integrated remote sensing imagery and two-dimensional hydraulic modeling approach are helpful for evaluating the influence of historical flood event on crop production and investigating the relationship between flood characteristics and crop yield losses.

  1. Simulation of Sediment Yield in a Semi-Arid River Basin under Changing Land Use: An Integrated Approach of Hydrologic Modelling and Principal Component Analysis

    Directory of Open Access Journals (Sweden)

    Charles Gyamfi

    2016-11-01

    Full Text Available Intensified human activities over the past decades have culminated in the prevalence of dire environmental consequences of sediment yield resulting mainly from land use changes. Understanding the role that land use changes play in the dynamics of sediment yield would greatly enhance decision-making processes related to land use and water resources management. In this study, we investigated the impacts of land use and cover changes on sediment yield dynamics through an integrated approach of hydrologic modelling and principal component analysis (PCA. A three-phase land use scenario (2000, 2007 and 2013 employing the “fix-changing” method was used to simulate the sediment yield of the Olifants Basin. Contributions in the changes in individual land uses to sediment yield were assessed using the component and pattern matrixes of PCA. Our results indicate that sediment yield dynamics in the study area is significantly attributed to the changes in agriculture, urban and forested lands. Changes in agriculture and urban lands were directly proportional to sediment yield dynamics of the Olifants Basin. On the contrary, forested areas had a negative relationship with sediment yield indicating less sediment yield from these areas. The output of this research work provides a simplistic approach of evaluating the impacts of land use changes on sediment yield. The tools and methods used are relevant for policy directions on land and water resources planning and management.

  2. Towards a comprehensive theory for He II: A temperature-dependent field-theoretic approach

    International Nuclear Information System (INIS)

    Ghassib, H.B.; Chela-Flores, J.

    1983-07-01

    New experimental aspects of He II, as well as recent developments in particle physics, are invoked to construct the rudiments of a comprehensive theory in which temperature-dependent U(1) and SU(2) gauge fields are incorporated into a hierarchy of effective Lagrangians. It is conjectured that an SU(n) gauge-theoretic description of superfluidity may be obtained in the limit n→infinity. However, it is outlined how experiments can be understood in the zeroth, first and second order of the hierarchy. (author)

  3. Ecosystem approach to fisheries: Exploring environmental and trophic effects on Maximum Sustainable Yield (MSY reference point estimates.

    Directory of Open Access Journals (Sweden)

    Rajeev Kumar

    Full Text Available We present a comprehensive analysis of estimation of fisheries Maximum Sustainable Yield (MSY reference points using an ecosystem model built for Mille Lacs Lake, the second largest lake within Minnesota, USA. Data from single-species modelling output, extensive annual sampling for species abundances, annual catch-survey, stomach-content analysis for predatory-prey interactions, and expert opinions were brought together within the framework of an Ecopath with Ecosim (EwE ecosystem model. An increase in the lake water temperature was observed in the last few decades; therefore, we also incorporated a temperature forcing function in the EwE model to capture the influences of changing temperature on the species composition and food web. The EwE model was fitted to abundance and catch time-series for the period 1985 to 2006. Using the ecosystem model, we estimated reference points for most of the fished species in the lake at single-species as well as ecosystem levels with and without considering the influence of temperature change; therefore, our analysis investigated the trophic and temperature effects on the reference points. The paper concludes that reference points such as MSY are not stationary, but change when (1 environmental conditions alter species productivity and (2 fishing on predators alters the compensatory response of their prey. Thus, it is necessary for the management to re-estimate or re-evaluate the reference points when changes in environmental conditions and/or major shifts in species abundance or community structure are observed.

  4. Developing Native-Like Listening Comprehension Materials Perceptions of a Digital Approach

    Directory of Open Access Journals (Sweden)

    Herri Mulyono

    2016-01-01

    Full Text Available This paper reported the attempt teachers did in developing native-like (NLS listening materials for their EFL learners using a text-to-speech (TTS technology. Observation was carried out to record teachers’ procedures for developing NLS materials. Interview with teachers were undertaken to explore their’ perceptions towards the NLS listening materials and the benefits they gained from developing instructional media using technology. In addition, a questionnaire was distributed to 65 eight-grade pupils to gather information related to their opinions regarding the listening materials developed and used by their teachers. The findings show that teachers and pupils responded positively towards the NLS materials for listening comprehension. In addition, teachers were found to have more confidence in teaching listening skill while using the technology. There are three conditions which endorse this teaching confidence: the suitability of instructional materials used with the learning curriculum and pupils’ level of English proficiency, teachers’ self-efficacy to the teaching task, and the integration of technology in classroom teaching. The study suggests that TTS system can be used as computer assisted language learning (CALL application particularly in the development of listening comprehension materials. The study also confirms earlier studies that teacher professional development can be promoted through integrated training on technology for classroom use.

  5. Addressing tuberculosis patients' medical and socio-economic needs: a comprehensive programmatic approach.

    Science.gov (United States)

    Contreras, Carmen C; Millones, Ana K; Santa Cruz, Janeth; Aguilar, Margot; Clendenes, Martin; Toranzo, Miguel; Llaro, Karim; Lecca, Leonid; Becerra, Mercedes C; Yuen, Courtney M

    2017-04-01

    For a cohort of patients with tuberculosis in Carabayllo, Peru, we describe the prevalence of medical comorbidities and socio-economic needs, the efforts required by a comprehensive support programme ('TB Cero') to address them and the success of this programme in linking patients to care. Patients diagnosed with tuberculosis in Carabayllo underwent evaluations for HIV, diabetes, mental health and unmet basic needs. For patients initiating treatment during 14 September, 2015-15 May, 2016, we abstracted data from evaluation forms and a support request system. We calculated the prevalence of medical comorbidities and the need for socio-economic support at the time of tuberculosis diagnosis, as well as the proportion of patients successfully linked to care or support. Of 192 patients, 83 (43%) had at least one medical comorbidity other than tuberculosis. These included eight (4%) patients with HIV, 12 (6%) with diabetes and 62 (32%) deemed at risk for a mental health condition. Of patients who required follow-up for a comorbidity, 100% initiated antiretroviral therapy, 71% attended endocrinology consultations and 66% attended psychology consultations. Of 126 (65%) patients who completed the socio-economic evaluation, 58 (46%) reported already receiving food baskets from the municipality, and 79 (63%) were given additional support, most commonly food vouchers and assistance in accessing health care. Carabayllo tuberculosis patients face many challenges in addition to tuberculosis. A collaborative, comprehensive treatment support programme can achieve high rates of linkage to care for these needs. © 2017 John Wiley & Sons Ltd.

  6. Geriatric work-up in the Nordic countries. The Nordic approach to comprehensive geriatric assessment

    DEFF Research Database (Denmark)

    Sletvold, O; Tilvis, R; Jonsson, A

    1996-01-01

    A group established by the Nordic professors of geriatrics has developed a position document presenting a shared and updated review of geriatric work-up as a way of comprehensive geriatric assessment in the Nordic countries. The main intention is that the document will serve as support and help f...... languages, and the translated versions should ideally have been subjected to validity and reliability testing. However, so far no scale meets these demands regarding all the five Nordic languages.......A group established by the Nordic professors of geriatrics has developed a position document presenting a shared and updated review of geriatric work-up as a way of comprehensive geriatric assessment in the Nordic countries. The main intention is that the document will serve as support and help...... for the clinician concerned with hospital based geriatric medicine. It may also be useful for quality control and teaching. Not least, it may be useful for health professionals other than geriatricians. To some extent, the position of geriatric medicine in the Nordic countries varies between the countries. However...

  7. Teaching Improvisation through Melody and Blues-Based Harmony: A Comprehensive and Sequential Approach

    Science.gov (United States)

    Heil, Leila

    2017-01-01

    This article describes a sequential approach to improvisation teaching that can be used with students at various age and ability levels by any educator, regardless of improvisation experience. The 2014 National Core Music Standards include improvisation as a central component in musical learning and promote instructional approaches that are…

  8. Comprehensive Reform for Urban High Schools: A Talent Development Approach. Sociology of Education Series.

    Science.gov (United States)

    Legters, Nettie E.; Balfanz, Robert; Jordan, Will J.; McPartland, James M.

    This book offers an alternative to current reform efforts, the talent development approach, detailing organizational, curricular, and instructional strategies that provide practitioners with a blueprint for whole school reform. The book presents the story of what happened in urban high schools when this approach was implemented. There are eight…

  9. Polymer Combustion as a Basis for Hybrid Propulsion: A Comprehensive Review and New Numerical Approaches

    Directory of Open Access Journals (Sweden)

    Vasily Novozhilov

    2011-10-01

    Full Text Available Hybrid Propulsion is an attractive alternative to conventional liquid and solid rocket motors. This is an active area of research and technological developments. Potential wide application of Hybrid Engines opens the possibility for safer and more flexible space vehicle launching and manoeuvring. The present paper discusses fundamental combustion issues related to further development of Hybrid Rockets. The emphasis is made on the two aspects: (1 properties of potential polymeric fuels, and their modification, and (2 implementation of comprehensive CFD models for combustion in Hybrid Engines. Fundamentals of polymeric fuel combustion are discussed. Further, steps necessary to accurately describe their burning behaviour by means of CFD models are investigated. Final part of the paper presents results of preliminary CFD simulations of fuel burning process in Hybrid Engine using a simplified set-up.

  10. Need for a comprehensive medical approach to the neuroimmuno-gastroenterology of irritable bowel syndrome

    Institute of Scientific and Technical Information of China (English)

    Pejman Katiraei; Gilberto Bultron

    2011-01-01

    Irritable bowel syndrome (IBS) is defined by the Rome Ⅲ criteria as symptoms of recurrent abdominal pain or discomfort with the onset of a marked change in bowel habits with no evidence of an inflammatory, anatomic,metabolic, or neoplastic process. As such, many clinicians regard IBS as a central nervous system problem of altered pain perception. Here, we review the recent literature and discuss the evidence that supports an organic based model, which views IBS as a complex,heterogeneous, inter-dependent, and multi-variable inflammatory process along the neuronal-gut axis. We delineate the organic pathophysiology of IBS, demonstrate the role of inflammation in IBS, review the possible differences between adult and pediatric IBS, discuss the merits of a comprehensive treatment model as taught by the Institute of Functional Medicine, and describe the potential for future research for this syndrome.

  11. A Comprehensive Approach to Bi-National Regional Energy Planning in the Pacific Northwest

    Energy Technology Data Exchange (ETDEWEB)

    Matt Morrison

    2007-12-31

    The Pacific NorthWest Economic Region, a statutory organization chartered by the Northwest states of Alaska, Washington, Idaho, Montana, and Oregon, and the western Canadian provinces of British Columbia, Alberta, and the Yukon through its Energy Working Group launched a bi-national energy planning initiative designed to create a Pacific Northwest energy planning council of regional public/private stakeholders from both Canada and the US. There is an urgent need to deal with the comprehensive energy picture now before our hoped for economic recovery results in energy price spikes which are likely to happen because the current supply will not meet predicted demand. Also recent events of August 14th have shown that our bi-national energy grid system is intricately interdependent, and additional planning for future capacity is desperately needed.

  12. Comprehensive Coaching Service for Schools: Approaches to its Configuration in Mexico

    Directory of Open Access Journals (Sweden)

    Graciela Cordero Arroyo

    2014-12-01

    Full Text Available This article analyzes the initial drafts of the Technical Assistance for Schools (SATE—acronym in Spanish—a comprehensive coaching service for which federal guidelines have yet to be established—in the context of current educational reform in Mexico. To this end, an analysis was made of all legal documents as well as various programmatic documents related to compulsory education that were released during 2013 and 2014. The paper is organized in three sections: the first describes the history of this type of service in Mexico; the second reviews the information provided on SATE in the legal documents of the current educational policy; and the third section discusses what should be taken into account for proper implementation of a service of this nature.

  13. Comprehensive approach to improving maternal health and achieving MDG 5: report from the mountains of Lesotho.

    Directory of Open Access Journals (Sweden)

    Hind Satti

    Full Text Available BACKGROUND: Although it is now widely recognized that reductions in maternal mortality and improvements in women's health cannot be achieved through simple, vertical strategies, few programs have provided successful models for how to integrate services into a comprehensive program for maternal health. We report our experience in rural Lesotho, where Partners In Health (PIH in partnership with the Ministry of Health and Social Welfare implemented a program that provides comprehensive care of pregnant women from the community to the clinic level. METHODS: Between May and July 2009, PIH trained 100 women, many of whom were former traditional birth attendants, to serve as clinic-affiliated maternal health workers. They received performance-based incentives for accompanying pregnant women during antenatal care (ANC visits and facility-based delivery. A nurse-midwife provided ANC and delivery care and supervised the maternal health workers. To overcome geographic barriers to delivering at the clinic, women who lived far from the clinic stayed at a maternal lying-in house prior to their expected delivery dates. We analyzed data routinely collected from delivery and ANC registers to compare service utilization before and after implementation of the program. RESULTS: After the establishment of the program, the average number first ANC visits increased from 20 to 31 per month. The clinic recorded 178 deliveries in the first year of the program and 216 in the second year, compared to 46 in the year preceding the program. During the first two years of the program, 49 women with complications were successfully transported to the district hospital, and no maternal deaths occurred among the women served by the program. CONCLUSIONS: Our results demonstrate that it is possible to achieve dramatic improvements in the utilization of maternal health services and facility-based delivery by strengthening human resource capacity, implementing active follow-up in the

  14. Comprehensive approach to ocular consequences of Stevens Johnson Syndrome - the aftermath of a systemic condition.

    Science.gov (United States)

    Iyer, Geetha; Srinivasan, Bhaskar; Agarwal, Shweta; Kamala Muralidharan, Seema; Arumugam, Sumathi

    2014-03-01

    Stevens Johnson Syndrome (SJS) can lead to end stage corneal blindness. This study describes the comprehensive treatment measures and their outcomes in the management of ocular sequelae and complications of SJS. Four hundred sixty-four eyes of 232 patients of SJS who underwent surgical intervention (punctal cautery, mucus membrane grafting for lid margin keratinisation, fornix reconstructive procedures, tectonic procedures, keratoplasty and keratoprosthesis) were studied. It was a non-comparative, retrospective, interventional case series. The primary outcome was the change in the best corrected visual acuity (BCVA). Secondary outcome measures included an improvement in the ocular surface status as indicated by corneal epithelial fluorescein staining and Schirmer's I strip wetting. The BCVA and the ocular surface status improved and/or stabilized in > 70 % of eyes following punctal cautery (n = 160) and > 80 % of eyes following lid margin mucus membrane grafting (n = 238). BCVA improved in 50 % of eyes following fornix reconstructive procedures (n = 24) with COMET (n = 6), in 63.9 % eyes with the Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) lens (n = 36), in 81.8 % of eyes after cataract surgery (n = 22). A BCVA of ≥20/200 was achieved in 72.34 % of eyes following keratoprostheses procedures (n = 47). The mean duration of follow up was 53.3 ± 15.2 months. The ocular sequelae of Stevens Johnson Syndrome can be blinding. They need to be identified and addressed early to retard the continued deterioration of the ocular surface. Our study aims to highlight the problem as well as the importance of comprehensive measures in the management of this potentially blinding disorder.

  15. Management of Substance Use Disorder in Military Services: A Comprehensive Approach.

    Science.gov (United States)

    Sharbafchi, Mohammad Reza; Heydari, Mostafa

    2017-01-01

    Historically, substance misuse has been a serious problem faced by worldwide military personnel. Some research showed that military personnel have higher rates of unhealthy substance use than their age peers in the general population. These problems have serious consequences and may lead to significant military difficulties in the field of readiness, discipline, and mental or physical health. In this review, we gathered various methods for prevention, diagnosis, and treatment of substance use disorders and suggested a comprehensive plan for Iran Armed Forces to improve existing services. This article is a narrative review study, which was carried out on 2016. A careful literature review was performed between January 1970 and April 2016 on several national and international databases. Articles were screened according to the following inclusion criteria: (1) review articles about prevention and treatment protocols, (2) executive guidance, (3) cohort articles about risk factors of addiction, and (4) randomized controlled trials about prevention or treatment of substance use disorders in army service members. After screening by title and abstract, 130 articles selected of 832 founded articles, and after quality assessment, finally, 63 articles included in the review. There is a necessity to manage substance use disorder through prevention, screening, and then referral to proper services for diagnosis and treatment. Urinalysis programs for screening are cost-effective and should be considered as a main method. Effective treatment includes both behavioral and pharmacological methods. The ideal prevention program will include multiple and mutually reinforcing evidence-based universal, selective, and indicated attempts at both the individual and environmental levels. The implementation of screening and treatment strategies needs strict rules and national guideline for the comprehensive management of substance use disorders in army.

  16. A Comprehensive Approach in Assessing the Performance of an Automobile Closed-Loop Supply Chain

    Directory of Open Access Journals (Sweden)

    Ezutah Udoncy Olugu

    2010-03-01

    Full Text Available The ecological issues arising from manufacturing operations have led to the focus on environmental sustainability in manufacturing. This can be addressed adequately using a closed-loop supply chain (CLSC. To attain an effective and efficient CLSC, it is necessary to imbibe a holistic performance measurement approach. In order to achieve this, there is a need to adopt a specific approach for a particular product rather than being generic. Since sustainability has direct environmental footprints that involve organizational stakeholders, suppliers, customers and the society at large, complexities surrounding supply chain performance measurement have multiplied. In this study, a suitable approach has been proposed for CLSC performance measurement in the automotive industry, based on reviewed literature. It is believed that this approach will result in increased effectiveness and efficiency in CLSC performance measurement.

  17. A comprehensive study on partial shading response of c-Si modules and yield modeling of string inverter and module level power electronics

    NARCIS (Netherlands)

    Sinapis, K.; Tzikas, C.; Litjens, G.; van den Donker, M.; Folkerts, W.; van Sark, W.G.J.H.M.; Smets, A.

    2016-01-01

    Building Integrated and Building Attached Photovoltaic (BIPV, BAPV) systems may suffer from lower performance than predicted as a result of not considered partial shading. New system architectures have been proposed to optimize performance. The common approach of these new architectures is to track

  18. Future Health and Economic Impact of Comprehensive Tobacco Control in DoD: A Microsimulation Approach.

    Science.gov (United States)

    Yang, Wenya; Zou, Quan; Tan, Eleonora; Watkins, Lachlan; Beronja, Kaleigh; Hogan, Paul F; Elenberg, Kimberly

    2018-01-01

    Tobacco use is a major concern to the Military Health System of the Department of Defense (DoD). The 2011 DoD Health Related Behavior Survey reported that 24.5% of active duty personnel are current smokers, which is higher than the national estimate of 20.6% for the civilian population. Overall, it is estimated that tobacco use costs the DoD $1.6 billion a year through related medical care, increased hospitalization, and lost days of work, among others. This study evaluated future health outcomes of Tricare Prime beneficiaries aged 18-64 yr (N = 3.2 million, including active duty and retired military members and their dependents) and the potential economic impact of initiatives that DoD may take to further its effort to transform the military into a tobacco-free environment. Our analysis simulated the future smoking status, risk of developing 25 smoking-related diseases, and associated medical costs for each individual using a Markov Chain Monte Carlo microsimulation model. Data sources included Tricare administrative data, national data such as Centers for Disease Control and Prevention mortality data and National Cancer Institute's cancer registry data, as well as relative risks of diseases obtained from a literature review. We found that the prevalence of active smoking among the Tricare Prime population will decrease from about 24% in 2015 to 18% in 2020 under a status quo scenario. However, if a comprehensive tobacco control initiative that includes a 5% price increase, a tighter clean air policy, and an intensified media campaign were to be implemented between 2016 and 2020, the prevalence of smoking could further decrease to 16%. The near 2 percentage points reduction in smoking prevalence represents an additional 81,240 quitters and translates to a total lifetime medical cost savings (in 2016 present value) of $968 million, with 39% ($382 million) attributable to Tricare savings. A comprehensive tobacco control policy within the DoD could significantly

  19. Comprehensive modelling for approaching the Kyoto targets on a local scale

    International Nuclear Information System (INIS)

    Pietrapertosa, F.; Macchiato, M.; Salvia, M.

    2003-01-01

    This study aimed to evaluate the effectiveness of the MARKAL comprehensive model in the development of coherent medium-term strategies and sound climate protection policies at local level. The local case study (Val d'Agri, Basilicata region, Italy) discusses the possible role of local communities in the achievement of the national objectives derived by the Kyoto Protocol, investigating the traditional sectors responsible for air pollution and providing a full picture of the main energy and material flows. A scenario analysis was performed to analyse the response of the modelled system to the introduction of an exogenous constraint on carbon dioxide (CO 2 ) emissions. The main effects are presented with reference to fuel mix, technology choice, real market prices and reduced costs of competing options. The comparison of the solutions obtained for the different scenarios is useful to point out the effects of the CO 2 constraint on the total system cost and on the emission levels of other atmospheric pollutants. A further multiobjective optimisation was performed to analyse the effects of combined environmental constraints (CO 2 and particulate) on the overall system cost as well as in terms of marginal costs. (author)

  20. Comprehensive modelling for approaching the Kyoto targets on a local scale

    Energy Technology Data Exchange (ETDEWEB)

    Pietrapertosa, F. [Istituto di Metodologie per l' Analisi Ambientale, Tito Scalo (Italy); Universita degli Studi della Basilicata, Potenza (Italy). Dipartimento di Ingegneria e Fisica dell' Ambiente; Cosmi, C.; Marmo, G. [Istituto di Metodologie per l' Analisi Ambientale, Tito Scalo (Italy); Istituto Nazionale di Fisica della Materia, Napoli (Italy); Macchiato, M. [Universita Federico II, Napoli (Italy). Dipartimento di Scienze Fisiche; Salvia, M. [Istituto di Metodologie per l' Analisi Ambientale, Tito Scalo (Italy)

    2003-06-01

    This study aimed to evaluate the effectiveness of the MARKAL comprehensive model in the development of coherent medium-term strategies and sound climate protection policies at local level. The local case study (Val d'Agri, Basilicata region, Italy) discusses the possible role of local communities in the achievement of the national objectives derived by the Kyoto Protocol, investigating the traditional sectors responsible for air pollution and providing a full picture of the main energy and material flows. A scenario analysis was performed to analyse the response of the modelled system to the introduction of an exogenous constraint on carbon dioxide (CO{sub 2}) emissions. The main effects are presented with reference to fuel mix, technology choice, real market prices and reduced costs of competing options. The comparison of the solutions obtained for the different scenarios is useful to point out the effects of the CO{sub 2} constraint on the total system cost and on the emission levels of other atmospheric pollutants. A further multiobjective optimisation was performed to analyse the effects of combined environmental constraints (CO{sub 2} and particulate) on the overall system cost as well as in terms of marginal costs. (author)

  1. Comprehensive approach to newborns and infants with brachial plexus impairment – proposal of Slovenian guidelines

    Directory of Open Access Journals (Sweden)

    Katja Groleger Sršen

    2015-06-01

    Full Text Available The impairment of brachial plexus (IBP in the neonate and infant remains an important problem. Risk factors for IBP are well known, but the mechanisms of impairment are not yet fully understood. It is important to identify early signs of IBP and to evaluate the hand function. In the guidelines we propose to use the Toronto scale for evaluation of hand function. The newborn with IBP should be referred to physiotherapy, and then regularly followed-up once a month. If the arm and hand function, especially flexion of the elbow, is not improving at the age of two months, the infant should be referred to the tertiary level rehabilitation centre and to department for plastic surgery at the University Medical Centre in Ljubljana. When necessary, the reconstructive procedure should be done by the age of three to six months. After reconstruction of brachial plexus, the child needs a comprehensive therapy program, which involves passive stretching, sensory stimulation, exercises to promote the development of active voluntary movements, bimanual activities, and symmetrical posture and movement patterns.

  2. A comprehensive approach for computation and implementation of efficient electricity transmission network charges

    Energy Technology Data Exchange (ETDEWEB)

    Olmos, Luis; Perez-Arriaga, Ignacio J. [Instituto de Investigacion Tecnologica, Universidad Pontificia Comillas, Alberto Aguilera, 23, 28015 Madrid (Spain)

    2009-12-15

    This paper presents a comprehensive design of electricity transmission charges that are meant to recover regulated network costs. In addition, these charges must be able to meet a set of inter-related objectives. Most importantly, they should encourage potential network users to internalize transmission costs in their location decisions, while interfering as least as possible with the short-term behaviour of the agents in the power system, since this should be left to regulatory instruments in the operation time range. The paper also addresses all those implementation issues that are essential for the sound design of a system of transmission network charges: stability and predictability of the charges; fair and efficient split between generation and demand charges; temporary measures to account for the low loading of most new lines; number and definition of the scenarios to be employed for the calculation and format of the final charges to be adopted: capacity, energy or per customer charges. The application of the proposed method is illustrated with a realistic numerical example that is based on a single scenario of the 2006 winter peak in the Spanish power system. (author)

  3. Spatial dynamics of ecosystem service flows: a comprehensive approach to quantifying actual services

    Science.gov (United States)

    Bagstad, Kenneth J.; Johnson, Gary W.; Voigt, Brian; Villa, Ferdinando

    2013-01-01

    Recent ecosystem services research has highlighted the importance of spatial connectivity between ecosystems and their beneficiaries. Despite this need, a systematic approach to ecosystem service flow quantification has not yet emerged. In this article, we present such an approach, which we formalize as a class of agent-based models termed “Service Path Attribution Networks” (SPANs). These models, developed as part of the Artificial Intelligence for Ecosystem Services (ARIES) project, expand on ecosystem services classification terminology introduced by other authors. Conceptual elements needed to support flow modeling include a service's rivalness, its flow routing type (e.g., through hydrologic or transportation networks, lines of sight, or other approaches), and whether the benefit is supplied by an ecosystem's provision of a beneficial flow to people or by absorption of a detrimental flow before it reaches them. We describe our implementation of the SPAN framework for five ecosystem services and discuss how to generalize the approach to additional services. SPAN model outputs include maps of ecosystem service provision, use, depletion, and flows under theoretical, possible, actual, inaccessible, and blocked conditions. We highlight how these different ecosystem service flow maps could be used to support various types of decision making for conservation and resource management planning.

  4. Twenty-five-year atraumatic restorative treatment (ART) approach: a comprehensive overview

    NARCIS (Netherlands)

    Frencken, J.E.; Leal, S.C.; Navarro, M.F.

    2012-01-01

    BACKGROUND: The atraumatic restorative treatment (ART) approach was born 25 years ago in Tanzania. It has evolved into an essential caries management concept for improving quality and access to oral care globally. RESULTS: Meta-analyses and systematic reviews have indicated that the high

  5. Understanding implementation of comprehensive geriatric care programs: a multiple perspective approach is preferred

    NARCIS (Netherlands)

    J.B.M. Vos; J.M. Cramm (Jane); J.D.H. van Wijngaarden (Jeroen); T.J.E.M. Bakker (Ton); J.P. Mackenbach (Johan); A.P. Nieboer (Anna)

    2017-01-01

    textabstractBackground: The Prevention and Reactivation Care Program (PReCaP) provides a novel approach targeting hospital-related functional decline among elderly patients. Despite the high expectations, the PReCaP was not effective in preventing functional decline (ADL and iADL) among older

  6. Modeling the impacts of climate change and technical progress on the wheat yield in inland China: An autoregressive distributed lag approach.

    Science.gov (United States)

    Zhai, Shiyan; Song, Genxin; Qin, Yaochen; Ye, Xinyue; Lee, Jay

    2017-01-01

    This study aims to evaluate the impacts of climate change and technical progress on the wheat yield per unit area from 1970 to 2014 in Henan, the largest agricultural province in China, using an autoregressive distributed lag approach. The bounded F-test for cointegration among the model variables yielded evidence of a long-run relationship among climate change, technical progress, and the wheat yield per unit area. In the long run, agricultural machinery and fertilizer use both had significantly positive impacts on the per unit area wheat yield. A 1% increase in the aggregate quantity of fertilizer use increased the wheat yield by 0.19%. Additionally, a 1% increase in machine use increased the wheat yield by 0.21%. In contrast, precipitation during the wheat growth period (from emergence to maturity, consisting of the period from last October to June) led to a decrease in the wheat yield per unit area. In the short run, the coefficient of the aggregate quantity of fertilizer used was negative. Land size had a significantly positive impact on the per unit area wheat yield in the short run. There was no significant short-run or long-run impact of temperature on the wheat yield per unit area in Henan Province. The results of our analysis suggest that climate change had a weak impact on the wheat yield, while technical progress played an important role in increasing the wheat yield per unit area. The results of this study have implications for national and local agriculture policies under climate change. To design well-targeted agriculture adaptation policies for the future and to reduce the adverse effects of climate change on the wheat yield, climate change and technical progress factors should be considered simultaneously. In addition, adaptive measures associated with technical progress should be given more attention.

  7. Modeling the impacts of climate change and technical progress on the wheat yield in inland China: An autoregressive distributed lag approach.

    Directory of Open Access Journals (Sweden)

    Shiyan Zhai

    Full Text Available This study aims to evaluate the impacts of climate change and technical progress on the wheat yield per unit area from 1970 to 2014 in Henan, the largest agricultural province in China, using an autoregressive distributed lag approach. The bounded F-test for cointegration among the model variables yielded evidence of a long-run relationship among climate change, technical progress, and the wheat yield per unit area. In the long run, agricultural machinery and fertilizer use both had significantly positive impacts on the per unit area wheat yield. A 1% increase in the aggregate quantity of fertilizer use increased the wheat yield by 0.19%. Additionally, a 1% increase in machine use increased the wheat yield by 0.21%. In contrast, precipitation during the wheat growth period (from emergence to maturity, consisting of the period from last October to June led to a decrease in the wheat yield per unit area. In the short run, the coefficient of the aggregate quantity of fertilizer used was negative. Land size had a significantly positive impact on the per unit area wheat yield in the short run. There was no significant short-run or long-run impact of temperature on the wheat yield per unit area in Henan Province. The results of our analysis suggest that climate change had a weak impact on the wheat yield, while technical progress played an important role in increasing the wheat yield per unit area. The results of this study have implications for national and local agriculture policies under climate change. To design well-targeted agriculture adaptation policies for the future and to reduce the adverse effects of climate change on the wheat yield, climate change and technical progress factors should be considered simultaneously. In addition, adaptive measures associated with technical progress should be given more attention.

  8. ψ(2S) and Υ(3S) hadroproduction in the parton Reggeization approach. Yield, polarization, and the role of fragmentation

    International Nuclear Information System (INIS)

    Kniehl, B.A.

    2016-09-01

    The hadroproduction of the radially excited heavy-quarkonium states ψ(2S) and Υ(3S) at high energies is studied in the parton Reggeization approach and the factorization formalism of nonrelativistic QCD at lowest order in the strong-coupling constant α_s and the relative heavy-quark velocity υ. A satisfactory description of the ψ(2S) transverse-momentum (p_T) distributions measured by ATLAS, CMS, and LHCb at center-of-mass energy √(S)=7 TeV is obtained using the color-octet long-distance matrix elements (LDMEs) extracted from CDF data at √(S)=1.96 TeV. The importance of the fragmentation mechanism and the scale evolution of the fragmentation functions in the upper p_T range, beyond 30 GeV, is demonstrated. The Υ(3S) p_T distributions measured by CDF at √(S)=1.8 TeV and by LHCb at √(S)=7 TeV and forward rapidities are well described using LDMEs fitted to ATLAS data at √(S)=7 TeV. Comparisons of polarization measurements by CDF and CMS at large p_T values with our predictions consolidate the familiar problem in the ψ(2S) case, but yield reasonable agreement in the Υ(3S) case.

  9. High-yielding and photolabile approaches to the covalent attachment of biomolecules to surfaces via hydrazone chemistry.

    Science.gov (United States)

    Lee, Ju Hun; Domaille, Dylan W; Noh, Hyunwoo; Oh, Taeseok; Choi, Chulmin; Jin, Sungho; Cha, Jennifer N

    2014-07-22

    The development of strategies to couple biomolecules covalently to surfaces is necessary for constructing sensing arrays for biological and biomedical applications. One attractive conjugation reaction is hydrazone formation--the reaction of a hydrazine with an aldehyde or ketone--as both hydrazines and aldehydes/ketones are largely bioorthogonal, which makes this particular reaction suitable for conjugating biomolecules to a variety of substrates. We show that the mild reaction conditions afforded by hydrazone conjugation enable the conjugation of DNA and proteins to the substrate surface in significantly higher yields than can be achieved with traditional bioconjugation techniques, such as maleimide chemistry. Next, we designed and synthesized a photocaged aryl ketone that can be conjugated to a surface and photochemically activated to provide a suitable partner for subsequent hydrazone formation between the surface-anchored ketone and DNA- or protein-hydrazines. Finally, we exploit the latent functionality of the photocaged ketone and pattern multiple biomolecules on the same substrate, effectively demonstrating a strategy for designing substrates with well-defined domains of different biomolecules. We expect that this approach can be extended to the production of multiplexed assays by using an appropriate mask with sequential photoexposure and biomolecule conjugation steps.

  10. A comprehensive approach to long-standing facial paralysis based on lengthening temporalis myoplasty.

    Science.gov (United States)

    Labbè, D; Bussu, F; Iodice, A

    2012-06-01

    Long-standing peripheral monolateral facial paralysis in the adult has challenged otolaryngologists, neurologists and plastic surgeons for centuries. Notwithstanding, the ultimate goal of normality of the paralyzed hemi-face with symmetry at rest, and the achievement of a spontaneous symmetrical smile with corneal protection, has not been fully reached. At the beginning of the 20(th) century, the main options were neural reconstructions including accessory to facial nerve transfer and hypoglossal to facial nerve crossover. In the first half of the 20(th) century, various techniques for static correction with autologous temporalis muscle and fascia grafts were proposed as the techniques of Gillies (1934) and McLaughlin (1949). Cross-facial nerve grafts have been performed since the beginning of the 1970s often with the attempt to transplant free-muscle to restore active movements. However, these transplants were non-vascularized, and further evaluations revealed central fibrosis and minimal return of function. A major step was taken in the second half of the 1970s, with the introduction of microneurovascular muscle transfer in facial reanimation, which, often combined in two steps with a cross-facial nerve graft, has become the most popular option for the comprehensive treatment of long-standing facial paralysis. In the second half of the 1990s in France, a regional muscle transfer technique with the definite advantages of being one-step, technically easier and relatively fast, namely lengthening temporalis myoplasty, acquired popularity and consensus among surgeons treating facial paralysis. A total of 111 patients with facial paralysis were treated in Caen between 1997 and 2005 by a single surgeon who developed 2 variants of the technique (V1, V2), each with its advantages and disadvantages, but both based on the same anatomo-functional background and aim, which is transfer of the temporalis muscle tendon on the coronoid process to the lips. For a comprehensive

  11. Focusing on changing clinical practice to enhance rational prescribing--collaboration and networking enable comprehensive approaches.

    Science.gov (United States)

    Helin-Salmivaara, Arja; Huupponen, Risto; Klaukka, Timo; Hoppu, Kalle

    2003-10-01

    Most western societies are enhancing rational pharmacotherapy to get best value for the constantly increasing expenditure on drugs. Government bodies and the medical profession took joint responsibility for the education programme for rational prescribing, launched in Finland at the end of the 1990s. The goals were to enhance critical thinking, and when appropriate, change prescribing behaviour. Various approaches that included evidence-based continuing medical education (CME), implementing clinical guidelines, delivering information, and providing prescribing feedback were used simultaneously. The commitment of the stakeholders and participants has been strong and the approaches have succeeded even though there is no clear outcome measure. The Government has recently decided to continue and widen the process, which started as a pilot programme, on a tight budget.

  12. SU-F-T-636: Comprehensive Approach to Motion Assessment for Liver and Pancreas SBRT Patients

    Energy Technology Data Exchange (ETDEWEB)

    Halvorsen, P; Iftimia, I; Hunter, K [Lahey Hospital and Medical Center, Burlington, MA (United States)

    2016-06-15

    Purpose: Our past practice for liver and pancreas SBRT consisted of free breathing (FB) with gated treatment delivery using a 30-70% phase window. We have recently adopted an assessment method leading to individualized motion management to minimize target motion. We present our results from 47 patients treated with this new approach. Methods: We perform an initial patient coaching and assessment session in our conventional simulator suite to observe the motion of the implanted fiducials with FB anterior and lateral 20-second cine acquisitions. The physician decides whether to attempt inhale or exhale breath-hold (BH). The patient is coached while observing with cine to ascertain their ability to achieve the desired BH mode for long periods as needed for treatment delivery. If the patient cannot comply, a FB approach is adopted using gating or simple ITV method (for patients without fiducials). After achieving a patient-specific motion management mode, we perform CT-simulation using the Varian RPM system to reproduce the chosen mode and record a reference session for treatment delivery. For pre-treatment imaging, the fiducials are observed under fluoro while coaching the patient. Results: Of 47 SBRT cases analyzed, 32 were liver and 15 were pancreas. The chosen techniques were: 32 exhale BH (12 with abdominal compression), 7 FB gated, 4 inhale BH, and 4 FB ITV. Maximum fiducial motion amplitude was 5 mm for the FB gated patients, and less than 5 mm for all BH patients with most able to achieve a maximum amplitude of 3 mm. Conclusion: This study showed that an individualized motion management approach can reduce the target volume and, therefore, the volume of irradiated healthy tissue from liver or pancreas SBRT. Effective coaching is essential in achieving consistent BH with 3 mm amplitude. The fluoro/cine session is helpful in establishing the right coaching approach for each patient.

  13. SU-F-T-636: Comprehensive Approach to Motion Assessment for Liver and Pancreas SBRT Patients

    International Nuclear Information System (INIS)

    Halvorsen, P; Iftimia, I; Hunter, K

    2016-01-01

    Purpose: Our past practice for liver and pancreas SBRT consisted of free breathing (FB) with gated treatment delivery using a 30-70% phase window. We have recently adopted an assessment method leading to individualized motion management to minimize target motion. We present our results from 47 patients treated with this new approach. Methods: We perform an initial patient coaching and assessment session in our conventional simulator suite to observe the motion of the implanted fiducials with FB anterior and lateral 20-second cine acquisitions. The physician decides whether to attempt inhale or exhale breath-hold (BH). The patient is coached while observing with cine to ascertain their ability to achieve the desired BH mode for long periods as needed for treatment delivery. If the patient cannot comply, a FB approach is adopted using gating or simple ITV method (for patients without fiducials). After achieving a patient-specific motion management mode, we perform CT-simulation using the Varian RPM system to reproduce the chosen mode and record a reference session for treatment delivery. For pre-treatment imaging, the fiducials are observed under fluoro while coaching the patient. Results: Of 47 SBRT cases analyzed, 32 were liver and 15 were pancreas. The chosen techniques were: 32 exhale BH (12 with abdominal compression), 7 FB gated, 4 inhale BH, and 4 FB ITV. Maximum fiducial motion amplitude was 5 mm for the FB gated patients, and less than 5 mm for all BH patients with most able to achieve a maximum amplitude of 3 mm. Conclusion: This study showed that an individualized motion management approach can reduce the target volume and, therefore, the volume of irradiated healthy tissue from liver or pancreas SBRT. Effective coaching is essential in achieving consistent BH with 3 mm amplitude. The fluoro/cine session is helpful in establishing the right coaching approach for each patient.

  14. Understanding implementation of comprehensive geriatric care programs: a multiple perspective approach is preferred

    OpenAIRE

    Vos, J.B.M.; Cramm, Jane; Wijngaarden, Jeroen; Bakker, Ton; Mackenbach, Johan; Nieboer, Anna

    2017-01-01

    Summary Background The Prevention and Reactivation Care Program (PReCaP) provides a novel approach targeting hospital‐related functional decline among elderly patients. Despite the high expectations, the PReCaP was not effective in preventing functional decline (ADL and iADL) among older patients. Although elderly PReCaP patients demonstrated slightly better cognitive functioning (Mini Mental State Examination; 0.4 [95% confidence interval (CI) 0.2–0.6]), lower depression (Geriatric Depressio...

  15. Comprehensive and market-based approaches to global-change policy

    International Nuclear Information System (INIS)

    Stewart, R.B.

    1992-01-01

    The summary highlights the need to take a system-wide approach to global change. The need to minimize costs while achieving environmental goals suggests the utility of employing market-based incentives that (1) ensure that the most is achieved by those who can do so at least cost and (2) encourage, innovation, rather than using 'command-and-control' tactics that mandate uniform adoption of centrally selected techniques. 18 refs

  16. A comprehensive approach to RCM-based preventive maintenance program development

    International Nuclear Information System (INIS)

    Hall, B.E.; Davis, T.; Pennington, A.J.

    1988-01-01

    In late 1986, Public Service Electric and Gas Company (PSE ampersand G) concluded that to support its vision and strategic planning it would be necessary to develop a consistent approach to maintenance for all nuclear units at the artificial island. General Physics Corporation was selected to lead a consultant team to support full-scale development of a preventive maintenance (PM) program for Salem and Hope Creek generating stations based on a reliability-centered maintenance (RCM) approach. RCM was selected because it represents a systematic approach to developing a PM program that provides a logical, consistent, and traceable methodology and produces a well-documented engineering basis for the program. Early in 1987, primary objectives for the PM program were defined. The Phase I tasks addressed key programmatic areas such as maintenance philosophy, procedures, condition monitoring, performance trending, equipment failure data base, ogranization, PM program effectiveness evaluation, RCM process, reliability/availability modeling, information management, training, spare parts, software/hardware, and commitments. Phase I of the PM program development project was completed in January 1988. Highlights of the Phase I work and the PM program manual are described

  17. Decision making in double-pedicled DIEP and SIEA abdominal free flap breast reconstructions: An algorithmic approach and comprehensive classification.

    Directory of Open Access Journals (Sweden)

    Charles M Malata

    2015-10-01

    Full Text Available Introduction: The deep inferior epigastric artery perforator (DIEP free flap is the gold standard for autologous breast reconstruction. However, using a single vascular pedicle may not yield sufficient tissue in patients with midline scars or insufficient lower abdominal pannus. Double-pedicled free flaps overcome this problem using different vascular arrangements to harvest the entire lower abdominal flap. The literature is, however, sparse regarding technique selection. We therefore reviewed our experience in order to formulate an algorithm and comprehensive classification for this purpose. Methods: All patients undergoing unilateral double-pedicled abdominal perforator free flap breast reconstruction (AFFBR by a single surgeon (CMM over 40 months were reviewed from a prospectively collected database. Results: Of the 112 consecutive breast free flaps performed, 25 (22% utilised two vascular pedicles. The mean patient age was 45 years (range=27-54. All flaps but one (which used the thoracodorsal system were anastomosed to the internal mammary vessels using the rib-preservation technique. The surgical duration was 656 minutes (range=468-690 mins. The median flap weight was 618g (range=432-1275g and the mastectomy weight was 445g (range=220-896g. All flaps were successful and only three patients requested minor liposuction to reduce and reshape their reconstructed breasts.Conclusion: Bipedicled free abdominal perforator flaps, employed in a fifth of all our AFFBRs, are a reliable and safe option for unilateral breast reconstruction. They, however, necessitate clear indications to justify the additional technical complexity and surgical duration. Our algorithm and comprehensive classification facilitate technique selection for the anastomotic permutations and successful execution of these operations.

  18. Outdoor human thermal perception in various climates: A comprehensive review of approaches, methods and quantification.

    Science.gov (United States)

    Potchter, Oded; Cohen, Pninit; Lin, Tzu-Ping; Matzarakis, Andreas

    2018-08-01

    Over the past century, many research studies have been conducted in an attempt to define thermal conditions for humans in the outdoor environment and to grade thermal sensation. Consequently, a large number of indices have been proposed. The examination of human thermal indices by thermal subjective perception has become recently a methodical issue to confirm the accuracy, applicability and validation of human thermal indices. The aims of this study are: (a) to review studies containing both calculated human thermal conditions and subjective thermal perception in the outdoor environment (b) to identify the most used human thermal indices for evaluating human thermal perception (c) to examine the relation between human thermal comfort range and outdoor thermal environment conditions and (d) to compare between categories of thermal sensation in different climatic zones based on subjective perception and levels of thermal strain. A comprehensive literature review identified 110 peer-reviewed articles which investigated in-situ thermal conditions versus subjective thermal perception during 2001-2017. It seems that out of 165 human thermal indices that have been developed, only 4 (PET, PMV, UTCI, SET*) are widely in use for outdoor thermal perception studies. Examination of the relation between human thermal comfort range and outdoor thermal environment conditions for selective indices in different climatic zones shows that the range of the thermal comfort or dis-comfort is affected by the outdoor thermal environment. For the PET index, the "neutral" range for hot climates of 24-26°C is agreed by 95% of the studies where for cold climate, the "neutral" range of 15-20°C is agreed by 89% of the studies. For the UTCI, the "no thermal stress" category is common to all climates. The "no stress category" of 16-23°C is agreed by 80% of the case studies, while 100% of the case studies agreed that the range is between 18 and 23°C. Copyright © 2018 Elsevier B.V. All rights

  19. The impact of soil amendments on greenhouse gas emissions: a comprehensive life cycle assessment approach

    Science.gov (United States)

    DeLonge, M. S.; Ryals, R.; Silver, W. L.

    2011-12-01

    Soil amendments, such as compost and manure, can be applied to grasslands to improve soil conditions and enhance aboveground net primary productivity. Applying such amendments can also lead to soil carbon (C) sequestration and, when materials are diverted from waste streams (e.g., landfills, manure lagoons), can offset greenhouse gas (GHG) emissions. However, amendment production and application is also associated with GHG emissions, and the net impact of these amendments remains unclear. To investigate the potential for soil amendments to reduce net GHG emissions, we developed a comprehensive, field-scale life cycle assessment (LCA) model. The LCA includes GHG (i.e., CO2, CH4, N2O) emissions of soil amendment production, application, and ecosystem response. Emissions avoided by diverting materials from landfills or manure management systems are also considered. We developed the model using field observations from grazed annual grassland in northern California (e.g., soil C; above- and belowground net primary productivity; C:N ratios; trace gas emissions from soils, manure piles, and composting), CENTURY model simulations (e.g., long-term soil C and trace gas emissions from soils under various land management strategies), and literature values (e.g., GHG emissions from transportation, inorganic fertilizer production, composting, and enteric fermentation). The LCA quantifies and contrasts the potential net GHG impacts of applying compost, manure, and commercial inorganic fertilizer to grazing lands. To estimate the LCA uncertainty, sensitivity tests were performed on the most widely ranging or highly uncertain parameters (e.g., compost materials, landfill emissions, manure management system emissions). Finally, our results are scaled-up to assess the feasibility and potential impacts of large-scale adoption of soil amendment application as a land-management strategy in California. Our base case results indicate that C sinks and emissions offsets associated with

  20. Towards a comprehensive theory for He II: I. A zero-temperature hybrid approach

    International Nuclear Information System (INIS)

    Ghassib, H.B.; Khudeir, A.M.

    1982-09-01

    A simple hybrid approach based on a gauge theory as well as a Hartree formalism, is presented for He II at zero temperature. Although this is intended to be merely a first step in an all-embracing theory, it already resolves quite neatly several old inconsistencies and corrects a few errors. As an illustration of its feasibility, a crude but instructive calculation is performed for the static structure factor of the system at low momentum transfers. A number of planned extensions and generalizations are outlined. (author)

  1. Simulating the yield impacts of organ-level quantitative trait loci associated with drought response in maize: a "gene-to-phenotype" modeling approach.

    Science.gov (United States)

    Chenu, Karine; Chapman, Scott C; Tardieu, François; McLean, Greg; Welcker, Claude; Hammer, Graeme L

    2009-12-01

    Under drought, substantial genotype-environment (G x E) interactions impede breeding progress for yield. Identifying genetic controls associated with yield response is confounded by poor genetic correlations across testing environments. Part of this problem is related to our inability to account for the interplay of genetic controls, physiological traits, and environmental conditions throughout the crop cycle. We propose a modeling approach to bridge this "gene-to-phenotype" gap. For maize under drought, we simulated the impact of quantitative trait loci (QTL) controlling two key processes (leaf and silk elongation) that influence crop growth, water use, and grain yield. Substantial G x E interaction for yield was simulated for hypothetical recombinant inbred lines (RILs) across different seasonal patterns of drought. QTL that accelerated leaf elongation caused an increase in crop leaf area and yield in well-watered or preflowering water deficit conditions, but a reduction in yield under terminal stresses (as such "leafy" genotypes prematurely exhausted the water supply). The QTL impact on yield was substantially enhanced by including pleiotropic effects of these QTL on silk elongation and on consequent grain set. The simulations obtained illustrated the difficulty of interpreting the genetic control of yield for genotypes influenced only by the additive effects of QTL associated with leaf and silk growth. The results highlight the potential of integrative simulation modeling for gene-to-phenotype prediction and for exploiting G x E interactions for complex traits such as drought tolerance.

  2. Dissecting grain yield pathways and their interactions with grain dry matter content by a two-step correlation approach with maize seedling transcriptome

    Directory of Open Access Journals (Sweden)

    Melchinger Albrecht E

    2010-04-01

    Full Text Available Abstract Background The importance of maize for human and animal nutrition, but also as a source for bio-energy is rapidly increasing. Maize yield is a quantitative trait controlled by many genes with small effects, spread throughout the genome. The precise location of the genes and the identity of the gene networks underlying maize grain yield is unknown. The objective of our study was to contribute to the knowledge of these genes and gene networks by transcription profiling with microarrays. Results We assessed the grain yield and grain dry matter content (an indicator for early maturity of 98 maize hybrids in multi-environment field trials. The gene expression in seedlings of the parental inbred lines, which have four different genetic backgrounds, was assessed with genome-scale oligonucleotide arrays. We identified genes associated with grain yield and grain dry matter content using a newly developed two-step correlation approach and found overlapping gene networks for both traits. The underlying metabolic pathways and biological processes were elucidated. Genes involved in sucrose degradation and glycolysis, as well as genes involved in cell expansion and endocycle were found to be associated with grain yield. Conclusions Our results indicate that the capability of providing energy and substrates, as well as expanding the cell at the seedling stage, highly influences the grain yield of hybrids. Knowledge of these genes underlying grain yield in maize can contribute to the development of new high yielding varieties.

  3. Teaching Games for Understanding: A Comprehensive Approach to Promote Student's Motivation in Physical Education.

    Science.gov (United States)

    Hortigüela Alcalá, David; Hernando Garijo, Alejandra

    2017-10-01

    It seems important to consider students' attitudes towards physical education (PE), and the way they learn sports. The present study examines students' perceptions of motivation and achievement in PE after experiencing three consecutive sport units. Two hundred and thirty seven students from the 1st, 2nd, 3rd, and 4th grade in a high school in Burgos (Spain) and two teachers agreed to participate. They were divided into two groups in order to compare two instructional approaches. The experimental group (A), 128 students, experienced Teaching Games for Understanding (TGfU), while the control group (B), 109 students, experienced a technical-traditional approach. Each group was taught by a different teacher. The study followed a mixed-method research design with quantitative (questionnaire) and qualitative (interview) data. Results revealed that group A showed greater motivation and achievement in PE than group B. Significant differences were found in achievement. Participants with better academic results in group A were more positive in sport participation. Meanwhile, students who practiced more extracurricular sports in group B were more actively involved in sport. Teachers disagreed greatly on the way sport should be taught in PE.

  4. The Comprehensive Approach to Assessing the Economic Security of the Industry Sector in Conditions of Globalization

    Directory of Open Access Journals (Sweden)

    Denysov Oleg Ye.

    2018-01-01

    Full Text Available The author carries out an empirical study of the level of economic security of the chemical industry sector of Ukraine in the direction of «production of polyvinyl chlorides». For this purpose the integral index of economic security has been calculated according to the model of functional-component blocks of economic security of sector, developed by the author. Application of this model allowed to research the algorithm of action of the model on the factual basis and to analyze the obtained indicators. This, in turn, made possible to draw a conclusion about the constructiveness and expediency of application of the model of basic functional-component blocks for calculating the level of economic security of the industry sector. With the help of this approach, with application of the complex, system-structural, dynamic and functional approaches, the level of economic security has been defined and the process of monitoring the status and level of economic security of the industry sector has been ensured.

  5. Innovative Approaches to Building Comprehensive Talent Pipelines: Helping to Grow a Strong and Diverse Professional Workforce

    Directory of Open Access Journals (Sweden)

    R. Cherinka

    2015-10-01

    Full Text Available The world today is constantly changing requiring organizations to adapt quickly and seek expertise to help meet the demands on their business. There are many workforce challenges that organizations seek to overcome, and one of the hardest things to do in modern corporations is to keep the talent pool young and vibrant. Early career hires tend to bring new and exciting ideas into play that may not even be considered by their more seasoned peers. The challenge with early career hires, especially in the Science, Technology, Engineeringand Math (STEM career fields, is the extreme difficulty in finding candidates who, not only have book knowledge, but also have hands-on, real world experience. Statistics show that this is a real concern to professional workforce employers. In this presentation, we highlight a model aimed at adopting new approaches for seeking and evaluating high quality candidates for on-boarding, conducting interviews and hiring to build a corporate talent pipeline. We discuss the model as it relates to recruiting, training, competition-based interviewing and providing hands-on work experience toward helping to build strong professionals in an organization. We conclude by highlighting several examples of successful approaches and their outcomes.

  6. A comprehensive approach to women’s health: lessons from the Mexican health reform

    Directory of Open Access Journals (Sweden)

    Frenk Julio

    2012-12-01

    Full Text Available Abstract Background This paper discusses the way in which women’s health concerns were addressed in Mexico as part of a health system reform. Discussion The first part sets the context by examining the growing complexity that characterizes the global health field, where women’s needs occupy center stage. Part two briefly describes a critical conceptual evolution, i.e. from maternal to reproductive to women’s health. In the third and last section, the novel “women and health” (W&H approach and its translation into policies and programs in the context of a structural health reform in Mexico is discussed. W&H simultaneously focuses on women’s health needs and women’s critical roles as both formal and informal providers of health care, and the links between these two dimensions. Summary The most important message of this paper is that broad changes in health systems offer the opportunity to address women’s health needs through innovative approaches focused on promoting gender equality and empowering women as drivers of change.

  7. Addressing water quality issues on a watershed basis: a comprehensive approach for utilizing chapter 20 of the Michigan drain code

    International Nuclear Information System (INIS)

    McCulloch, J.P.

    2002-01-01

    There are five major watersheds in Oakland County. They are the Clinton, Flint, Huron, Rouge and Shiawassee. Included in these watersheds are 61 individual cities, villages and townships. Actions taken by one community within the watershed have a significant impact on other communities in the watershed. Consequently, a multi-community approach needs to be identified and utilized to comprehensively address public health and water quality issues. Some of the issues faced by these communities individually include stormwater management, flooding, drainage, and river and stream management. Failing septic systems, illicit connections causing groundwater contamination, and habitat and wetland degradation are also primary concerns. Finally, wastewater treatment capacity and sanitary sewer service also are regularly dealt with by these communities. Traditionally, short-term solutions to these often urgent problems required the construction of relief sewers or temporary retention structures. Unfortunately, solving the problem in one area often meant the creation of new problems downstream. Coordinating efforts among these 61 individual communities is difficult. These difficult challenges are best met with a coordinated, comprehensive plan. (author)

  8. Planning and support materials in teaching story comprehension from the interbehavioral approach

    Directory of Open Access Journals (Sweden)

    Ana Cristina Mascareño Bórquez

    2017-12-01

    Full Text Available Despite the latest changes in educational reforms within the country, curriculum plans and ongoing program renewals aimed at resolving the educational gap reflected in national statistics, the results remain unfavorable. This leads to reflection and analysis to generate and implement new forms and teaching strategies. The purpose of this paper is to present the design of an alternative proposal for planning and the development of support materials, developed according to the second block of sixth grade primary education, in two expected learning contained in the formal basic education curriculum. Centered on the interaction in teaching-learning and according to different levels of functional aptitude. Subsequently it underwent a process of piloting and revision by experts to prove the pertinence of the planning and precisions for its implementation. As results, the support materials and the planning proposal are presented and discussed with the authors who have worked on planning proposals from the inter-behavioral approach.

  9. A Comprehensive Approach to Risk Reduction for Asian and Pacific Islander American Women With HIV/AIDS.

    Science.gov (United States)

    Sabato, Todd M

    2014-07-01

    As HIV incidence rises globally, Asian and Pacific Islander communities are increasingly affected. While often overlooked, Asian and Pacific Islander American women have shown the greatest percentage increase in HIV diagnosis rates. The development of a multilevel and multistrategy approach to HIV/AIDS education, prevention, and treatment among Asian and Pacific Islander females requires health care providers to identify personal and cultural barriers to prevention and treatment and implement culturally sensitive and specific measures. The purpose of this article is to illuminate barriers to HIV-related prevention, treatment, and care among Asian and Pacific Islander American females and provide practical application-based suggestions for providers, which may enhance Asian and Pacific Islander female inclusion in comprehensive HIV prevention. © The Author(s) 2014.

  10. A comprehensive approach to addiction medicine as an appropriate response to the HIV epidemic among drug users.

    Science.gov (United States)

    Gerra, Gilberto

    2013-12-01

    The services for drug-dependence treatment and care, particularly in low-income countries, should not be fragmented and uncoordinated. A basic package of interventions should be provided in the same place and managed by the same team, with a one-stop shop approach. The services for substance use disorders should be appealing, accessible, voluntary-based, and science-based. They should also, like efforts to fight other diseases, be included in the community and the public health systems; that is, those who are affected by drug use and those who serve them should not face discrimination. The first-line assistance and the second-line essential elements of the comprehensive package will be described. The work of the United Nations Office on Drugs and Crime (UNODC) and World Health Organization (WHO) to promote science-based and voluntary-based ethical treatment in Asia will be illustrated.

  11. Comprehensive computational model for combining fluid hydrodynamics, light transport and biomass growth in a Taylor vortex algal photobioreactor: Lagrangian approach.

    Science.gov (United States)

    Gao, Xi; Kong, Bo; Vigil, R Dennis

    2017-01-01

    A comprehensive quantitative model incorporating the effects of fluid flow patterns, light distribution, and algal growth kinetics on biomass growth rate is developed in order to predict the performance of a Taylor vortex algal photobioreactor for culturing Chlorella vulgaris. A commonly used Lagrangian strategy for coupling the various factors influencing algal growth was employed whereby results from computational fluid dynamics and radiation transport simulations were used to compute numerous microorganism light exposure histories, and this information in turn was used to estimate the global biomass specific growth rate. The simulations provide good quantitative agreement with experimental data and correctly predict the trend in reactor performance as a key reactor operating parameter is varied (inner cylinder rotation speed). However, biomass growth curves are consistently over-predicted and potential causes for these over-predictions and drawbacks of the Lagrangian approach are addressed. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. Comprehensive evaluation of genome-wide 5-hydroxymethylcytosine profiling approaches in human DNA.

    Science.gov (United States)

    Skvortsova, Ksenia; Zotenko, Elena; Luu, Phuc-Loi; Gould, Cathryn M; Nair, Shalima S; Clark, Susan J; Stirzaker, Clare

    2017-01-01

    The discovery that 5-methylcytosine (5mC) can be oxidized to 5-hydroxymethylcytosine (5hmC) by the ten-eleven translocation (TET) proteins has prompted wide interest in the potential role of 5hmC in reshaping the mammalian DNA methylation landscape. The gold-standard bisulphite conversion technologies to study DNA methylation do not distinguish between 5mC and 5hmC. However, new approaches to mapping 5hmC genome-wide have advanced rapidly, although it is unclear how the different methods compare in accurately calling 5hmC. In this study, we provide a comparative analysis on brain DNA using three 5hmC genome-wide approaches, namely whole-genome bisulphite/oxidative bisulphite sequencing (WG Bis/OxBis-seq), Infinium HumanMethylation450 BeadChip arrays coupled with oxidative bisulphite (HM450K Bis/OxBis) and antibody-based immunoprecipitation and sequencing of hydroxymethylated DNA (hMeDIP-seq). We also perform loci-specific TET-assisted bisulphite sequencing (TAB-seq) for validation of candidate regions. We show that whole-genome single-base resolution approaches are advantaged in providing precise 5hmC values but require high sequencing depth to accurately measure 5hmC, as this modification is commonly in low abundance in mammalian cells. HM450K arrays coupled with oxidative bisulphite provide a cost-effective representation of 5hmC distribution, at CpG sites with 5hmC levels >~10%. However, 5hmC analysis is restricted to the genomic location of the probes, which is an important consideration as 5hmC modification is commonly enriched at enhancer elements. Finally, we show that the widely used hMeDIP-seq method provides an efficient genome-wide profile of 5hmC and shows high correlation with WG Bis/OxBis-seq 5hmC distribution in brain DNA. However, in cell line DNA with low levels of 5hmC, hMeDIP-seq-enriched regions are not detected by WG Bis/OxBis or HM450K, either suggesting misinterpretation of 5hmC calls by hMeDIP or lack of sensitivity of the latter methods. We

  13. Children's exposure to harmful elements in toys and low-cost jewelry: Characterizing risks and developing a comprehensive approach

    International Nuclear Information System (INIS)

    Guney, Mert; Zagury, Gerald J.

    2014-01-01

    Highlights: • Risk for children up to 3 years-old was characterized considering oral exposure. • Saliva mobilization, ingestion of parts and of scraped-off material were considered. • Ingestion of parts caused hazard index (HI) values >>for Cd, Ni, and Pb exposure. • HI were lower (but > for saliva mobilization and 1, up to 75, 5.8, and 43, respectively). HI for ingestion of scraped-off material scenario was always 1 in three samples (two for Cd, one for Ni). Risk characterization identified different potentially hazardous items compared to United States, Canadian, and European Union approaches. A comprehensive approach was also developed to deal with complexity and drawbacks caused by various toy/jewelry definitions, test methods, exposure scenarios, and elements considered in different regulatory approaches. It includes bioaccessible limits for eight priority elements (As, Cd, Cr, Cu, Hg, Ni, Pb, and Sb). Research is recommended on metals bioaccessibility determination in toys/jewelry, in vitro bioaccessibility test development, estimation of material ingestion rates and frequency, presence of hexavalent Cr and organic Sn, and assessment of prolonged exposure to MJ

  14. Children's exposure to harmful elements in toys and low-cost jewelry: characterizing risks and developing a comprehensive approach.

    Science.gov (United States)

    Guney, Mert; Zagury, Gerald J

    2014-04-30

    Contamination problem in jewelry and toys and children's exposure possibility have been previously demonstrated. For this study, risk from oral exposure has been characterized for highly contaminated metallic toys and jewelry ((MJ), n=16) considering three scenarios. Total and bioaccessible concentrations of Cd, Cu, Ni, and Pb were high in selected MJ. First scenario (ingestion of parts or pieces) caused unacceptable risk for eight items for Cd, Ni, and/or Pb (hazard index (HI)>1, up to 75, 5.8, and 43, respectively). HI for ingestion of scraped-off material scenario was always 1 in three samples (two for Cd, one for Ni). Risk characterization identified different potentially hazardous items compared to United States, Canadian, and European Union approaches. A comprehensive approach was also developed to deal with complexity and drawbacks caused by various toy/jewelry definitions, test methods, exposure scenarios, and elements considered in different regulatory approaches. It includes bioaccessible limits for eight priority elements (As, Cd, Cr, Cu, Hg, Ni, Pb, and Sb). Research is recommended on metals bioaccessibility determination in toys/jewelry, in vitro bioaccessibility test development, estimation of material ingestion rates and frequency, presence of hexavalent Cr and organic Sn, and assessment of prolonged exposure to MJ. Copyright © 2014 Elsevier B.V. All rights reserved.

  15. A comprehensive approach to dark matter studies: exploration of simplified top-philic models

    Energy Technology Data Exchange (ETDEWEB)

    Arina, Chiara; Backović, Mihailo [Centre for Cosmology, Particle Physics and Phenomenology (CP3),Université catholique de Louvain, Chemin du Cyclotron 2, B-1348 Louvain-la-Neuve (Belgium); Conte, Eric [Groupe de Recherche de Physique des Hautes Énergies (GRPHE), Université de Haute-Alsace,IUT Colmar, F-68008 Colmar Cedex (France); Fuks, Benjamin [Sorbonne Universités, UPMC University Paris 06, UMR 7589, LPTHE, F-75005, Paris (France); CNRS, UMR 7589, LPTHE, F-75005, Paris (France); Guo, Jun [State Key Laboratory of Theoretical Physics, Institute of Theoretical Physics,Chinese Academy of Sciences, Beijing 100190 (China); Institut Pluridisciplinaire Hubert Curien/Département Recherches Subatomiques,Université de Strasbourg/CNRS-IN2P3, F-67037 Strasbourg (France); Heisig, Jan [Institute for Theoretical Particle Physics and Cosmology, RWTH Aachen University,Sommerfeldstr. 16, D-52056 Aachen (Germany); Hespel, Benoît [Centre for Cosmology, Particle Physics and Phenomenology (CP3),Université catholique de Louvain, Chemin du Cyclotron 2, B-1348 Louvain-la-Neuve (Belgium); Krämer, Michael [Institute for Theoretical Particle Physics and Cosmology, RWTH Aachen University,Sommerfeldstr. 16, D-52056 Aachen (Germany); Maltoni, Fabio; Martini, Antony [Centre for Cosmology, Particle Physics and Phenomenology (CP3),Université catholique de Louvain, Chemin du Cyclotron 2, B-1348 Louvain-la-Neuve (Belgium); Mawatari, Kentarou [Laboratoire de Physique Subatomique et de Cosmologie, Université Grenoble-Alpes,CNRS/IN2P3, 53 Avenue des Martyrs, F-38026 Grenoble (France); Theoretische Natuurkunde and IIHE/ELEM, Vrije Universiteit Brussel andInternational Solvay Institutes, Pleinlaan 2, B-1050 Brussels (Belgium); Pellen, Mathieu [Universität Würzburg, Institut für Theoretische Physik und Astrophysik,Emil-Hilb-Weg 22, 97074 Würzburg (Germany); Vryonidou, Eleni [Centre for Cosmology, Particle Physics and Phenomenology (CP3),Université catholique de Louvain, Chemin du Cyclotron 2, B-1348 Louvain-la-Neuve (Belgium)

    2016-11-21

    Studies of dark matter lie at the interface of collider physics, astrophysics and cosmology. Constraining models featuring dark matter candidates entails the capability to provide accurate predictions for large sets of observables and compare them to a wide spectrum of data. We present a framework which, starting from a model Lagrangian, allows one to consistently and systematically make predictions, as well as to confront those predictions with a multitude of experimental results. As an application, we consider a class of simplified dark matter models where a scalar mediator couples only to the top quark and a fermionic dark sector (i.e. the simplified top-philic dark matter model). We study in detail the complementarity of relic density, direct/indirect detection and collider searches in constraining the multi-dimensional model parameter space, and efficiently identify regions where individual approaches to dark matter detection provide the most stringent bounds. In the context of collider studies of dark matter, we point out the complementarity of LHC searches in probing different regions of the model parameter space with final states involving top quarks, photons, jets and/or missing energy. Our study of dark matter production at the LHC goes beyond the tree-level approximation and we show examples of how higher-order corrections to dark matter production processes can affect the interpretation of the experimental results.

  16. Recent Trends in Therapeutic Approaches for Diabetes Management: A Comprehensive Update

    Directory of Open Access Journals (Sweden)

    Pragya Tiwari

    2015-01-01

    Full Text Available Diabetes highlights a growing epidemic imposing serious social economic crisis to the countries around the globe. Despite scientific breakthroughs, better healthcare facilities, and improved literacy rate, the disease continues to burden several sections, especially middle and low income countries. The present trends indicate the rise in premature death, posing a major threat to global development. Scientific and technological advances have witnessed the development of newer generation of drugs like sulphonylureas, biguanides, alpha glucosidase inhibitors, and thiazolidinediones with significant efficacy in reducing hyperglycemia. Recent approaches in drug discovery have contributed to the development of new class of therapeutics like Incretin mimetics, Amylin analogues, GIP analogs, Peroxisome proliferator activated receptors, and dipeptidyl peptidase-4 inhibitor as targets for potential drugs in diabetes treatment. Subsequently, the identification and clinical investigation of bioactive substances from plants have revolutionized the research on drug discovery and lead identification for diabetes management. With a focus on the emerging trends, the review article explores the current statistical prevalence of the disease, discussing the benefits and limitations of the commercially available drugs. Additionally, the critical areas in clinical diabetology are discussed, with respect to prospects of statins, nanotechnology, and stem cell technology as next generation therapeutics and why the herbal formulations are consistently popular choice for diabetes medication and management.

  17. Comprehensive approach to smart urban development based on Big Data application

    Science.gov (United States)

    Kurcheeva, G. I.; Klochkov, G. A.

    2018-05-01

    Despite a certain technological backwardness of the Russian economy, the authors believe that the transition to the «smart city» is possible if one can solve such problems: providing large-scale investment, training and retraining specialists in the field of ICT, increasing innovation managers and consumers, increasing ICT participation in the work of governments, organizations and people, creating the appropriate conditions for the development of the information society. Accordingly, when developing models, it is planned to consider the relationship between quality of life and the existing system of indicators on trends of «smart cities». Monitoring of indicators of quality of life, mutually related indicators of technological development can help us develop the process model. When selecting directions for the main components of the «smart city», let us introduce the evaluation criteria that significantly affect the quality of the values of life. The development of «smart cities» should consider the international experience of the use of breakthrough innovative technology. Research scientists of various countries show a variety of approaches to identifying the main business processes in models of the «smart city». Having the international experience, it is necessary to improve business processes in the construction of a process model «smart city», adapting the model to the characteristics of the national environment.

  18. A comprehensive energy approach to predict fatigue life in CuAlBe shape memory alloy

    International Nuclear Information System (INIS)

    Sameallah, S; Kadkhodaei, M; Legrand, V; Saint-Sulpice, L; Arbab Chirani, S

    2015-01-01

    Stabilized dissipated energy is an effective parameter on the fatigue life of shape memory alloys (SMAs). In this study, a formula is proposed to directly evaluate the stabilized dissipated energy for different values of the maximum and minimum applied stresses, as well as the loading frequency, under cyclic tensile loadings. To this aim, a one-dimensional fully coupled thermomechanical constitutive model and a cycle-dependent phase diagram are employed to predict the uniaxial stress-strain response of an SMA in a specified cycle, including the stabilized one, with no need of obtaining the responses of the previous cycles. An enhanced phase diagram in which different slopes are defined for the start and finish of a backward transformation strip is also proposed to enable the capture of gradual transformations in a CuAlBe shape memory alloy. It is shown that the present approach is capable of reproducing the experimental responses of CuAlBe specimens under cyclic tensile loadings. An explicit formula is further presented to predict the fatigue life of CuAlBe as a function of the maximum and minimum applied stresses as well as the loading frequency. Fatigue tests are also carried out, and this formula is verified against the empirically predicted number of cycles for failure. (paper)

  19. A comprehensive energy approach to predict fatigue life in CuAlBe shape memory alloy

    Science.gov (United States)

    Sameallah, S.; Legrand, V.; Saint-Sulpice, L.; Kadkhodaei, M.; Arbab Chirani, S.

    2015-02-01

    Stabilized dissipated energy is an effective parameter on the fatigue life of shape memory alloys (SMAs). In this study, a formula is proposed to directly evaluate the stabilized dissipated energy for different values of the maximum and minimum applied stresses, as well as the loading frequency, under cyclic tensile loadings. To this aim, a one-dimensional fully coupled thermomechanical constitutive model and a cycle-dependent phase diagram are employed to predict the uniaxial stress-strain response of an SMA in a specified cycle, including the stabilized one, with no need of obtaining the responses of the previous cycles. An enhanced phase diagram in which different slopes are defined for the start and finish of a backward transformation strip is also proposed to enable the capture of gradual transformations in a CuAlBe shape memory alloy. It is shown that the present approach is capable of reproducing the experimental responses of CuAlBe specimens under cyclic tensile loadings. An explicit formula is further presented to predict the fatigue life of CuAlBe as a function of the maximum and minimum applied stresses as well as the loading frequency. Fatigue tests are also carried out, and this formula is verified against the empirically predicted number of cycles for failure.

  20. Comprehensive and Methodical: Diagnostic and Management Approaches to Rapidly Progressive Dementia.

    Science.gov (United States)

    Mahajan, Supriya; Appleby, Brian S

    2017-09-30

    Purpose of review The sudden emergence of a change in cognitive abilities or behavior is an important symptom that warrants medical evaluation and may represent the early stages of a rapidly progressive dementia (RPD). To correctly ascertain the cause of RPD in a given patient, the clinician must be methodical and knowledgeable about the range of potential causes and must move forward with supportive treatment, and in some cases empiric treatment, based on clinical features alone. Recent findings Significant advances in prion disease biomarkers, the molecular features of rapidly progressive Alzheimer's disease, and new detection of autoimmune limbic encephalitis disease entities have caused a shift in the diagnostic and treatment framework of RPD. Additionally, in the past decade, emerging retrospective data have led to suggested treatments in autoimmune encephalitis that, if instituted early, can protect patients against residual deficits and disease relapse. Summary Here, we provide an integrative clinical and diagnostic treatment approach that is applicable to the various forms of RPD. We have highlighted the clinical features of selected types of RPD that have experienced advances in the last 10-15 years.

  1. Skull base tumors: a comprehensive review of transfacial swing osteotomy approaches.

    Science.gov (United States)

    Moreira-Gonzalez, Andrea; Pieper, Daniel R; Cambra, Jorge Balaguer; Simman, Richard; Jackson, Ian T

    2005-03-01

    Numerous techniques have been proposed for the resection of skull base tumors, each one unique with regard to the region exposed and degree of technical complexity. This study describes the use of transfacial swing osteotomies in accessing lesions located at various levels of the cranial base. Eight patients who underwent transfacial swings for exposure and resection of cranial base lesions between 1996 and 2002 were studied. The mandible was the choice when wide exposure of nasopharyngeal and midline skull base tumors was necessary, especially when they involved the infratemporal fossa. The midfacial swing osteotomy was an option when access to the entire clivus was necessary. An orbital swing approach was used to access large orbital tumors lying inferior to the optic nerve and posterior to the globe, a region that is often difficult to visualize. Gross total tumor excision was possible in all patients. Six patients achieved disease control and two had recurrences. The complications of cerebrospinal fluid leak, infection, hematoma, or cranial nerve damage did not occur. After surgery, some patients experienced temporary symptoms caused by local swelling. The aesthetic result was considered good. Transfacial swing osteotomies provide a wide exposure to tumors that occur in the central skull base area. Excellent knowledge of the detailed anatomy of this region is paramount to the success of this surgery. The team concept is essential; it is built around the craniofacial surgeon and an experienced skull base neurosurgeon.

  2. Standardization of Unani polyherbal formulation, Qurse-e-Hummaz: A comprehensive approach

    Directory of Open Access Journals (Sweden)

    Y T Kamal

    2016-01-01

    Full Text Available Background: An increase in the awareness about the advantages of the traditional system of medicines has led to the commercialization of the formulations used for the treatments. Manufacture of these medicines to meet this increasing demand has resulted in a decline in their quality, primarily due to a lack of adequate regulations pertaining to this sector of medicine. Hence, it is necessary to come up with a systematic approach to develop well-designed methodologies for the standardization of polyherbal formulations which are used in traditional systems of medicine. Materials and Methods: Qurs-e-Hummaz formulations were prepared by a qualified “Hakim” (Unani medical practitioner of Faculty of Unani Medicine, Hamdard University, as per the formula and instruction given in National Formulary of Unani Medicine. Results: Various quality control parameters such as organoleptic evaluations (color, odor, taste, and consistency, physicochemical evaluations (loss on drying, disintegration time, moisture content, total ash, acid insoluble ash, water soluble ash, pH of 1 and 10% solution, extractive values, water soluble matter, alcohol-soluble matter, and total phenolic content and thin layer chromatography fingerprint profiling have been carried out in triplicate. The evaluation of contaminants such as heavy metals, aflatoxins, pesticide residues, and microbial contamination has also been carried out in the formulation. Conclusion: Help in maintaining the quality and batch to batch consistency of many important polyherbal formulations.

  3. Low pressure steam expansion pretreatment as a competitive approach to improve diosgenin yield and the production of fermentable sugar from Dioscorea zingiberensis C.H. Wright.

    Science.gov (United States)

    Wei, Mi; Tong, Yao; Wang, Hongbo; Wang, Lihua; Yu, Longjiang

    2016-04-01

    Development of efficient pretreatment methods which can disrupt the peripheral lignocellulose and even the parenchyma cells is of great importance for production of diosgenin from turmeric rhizomes. It was found that low pressure steam expansion pretreatment (LSEP) could improve the diosgenin yield by more than 40% compared with the case without pretreatment, while simultaneously increasing the production of fermentable sugar by 27.37%. Furthermore, little inhibitory compounds were produced in LSEP process which was extremely favorable for the subsequent biotransformation of fermentable sugar to other valuable products such as ethanol. Preliminary study showed that the ethanol yield when using the fermentable sugar as carbon source was comparable to that using glucose. The liquid residue of LSEP treated turmeric tuber after diosgenin production can be utilized as a quality fermentable carbon source. Therefore, LSEP has great potential in industrial application in diosgenin clean production and comprehensive utilization of turmeric tuber. Copyright © 2016 Elsevier Ltd. All rights reserved.

  4. The Impact on Anxiety and Depression of a Whole School Approach to Health Promotion: Evidence from a Canadian Comprehensive School Health (CSH) Initiative

    Science.gov (United States)

    Dassanayake, Wijaya; Springett, Jane; Shewring, Tania

    2017-01-01

    In this paper, we examine the impact of adopting a comprehensive school health (CSH) approach on reducing anxiety and depression of school-age children. We use the data from 245 schools that received government funding support to adopt a CSH approach in order to build health promoting school environments in Alberta. Using a linear multi-level…

  5. A consistent approach for the development of a comprehensive data base of time-dependent parameters for concrete engineered barriers

    Energy Technology Data Exchange (ETDEWEB)

    Seetharam, Suresh C; Perko, Janez; Jacques, Diederik [Belgian Nuclear Research Centre SCK-CEN, Mol (Belgium); Mallants, Dirk [CSIRO Land and Water, Urrbrae (Australia)

    2013-07-01

    This paper presents a consistent approach for the development of a comprehensive data base of time-dependent hydraulic and transport parameters for concrete engineered barriers of the future Dessel near surface repository for low level waste. The parameter derivation is based on integration of selected data obtained through an extensive literature review, data from experimental studies on cementitious materials specific for the Dessel repository and numerical modelling using physically-based models of water and mass transport. Best estimate parameter values for assessment calculations are derived, together with source and expert range and their probability density function wherever the data was sufficient. We further discuss a numerical method for up-scaling laboratory derived parameter values to the repository scale; the resulting large-scale effective parameters are commensurate with numerical grids used in models for radionuclide migration. To accommodate different levels of conservatism in the various assessment calculations defined by ONDRAF/NIRAS, several sets of parameter values have been derived based on assumptions that introduce different degrees of conservatism. For pertinent parameters, the time evolution of such properties due to the long-term concrete degradation is also addressed. The implementation of the consistent approach is demonstrated by considering the pore water diffusion coefficient as an example. (authors)

  6. The impact of tropospheric ozone pollution on trial plot winter wheat yields in Great Britain - an econometric approach.

    Science.gov (United States)

    Kaliakatsou, Evridiki; Bell, J Nigel B; Thirtle, Colin; Rose, Daniel; Power, Sally A

    2010-05-01

    Numerous experiments have demonstrated reductions in the yields of cereal crops due to tropospheric O(3), with losses of up to 25%. However, the only British econometric study on O(3) impacts on winter wheat yields, found that a 10% increase in AOT40 would decrease yields by only 0.23%. An attempt is made here to reconcile these observations by developing AOT40 maps for Great Britain and matching levels with a large number of standardised trial plot wheat yields from many sites over a 13-year period. Panel estimates (repeated measures on the same plots with time) show a 0.54% decrease in yields and it is hypothesised that plant breeders may have inadvertently selected for O(3) tolerance in wheat. Some support for this is provided by fumigations of cultivars of differing introduction dates. A case is made for the use of econometric as well as experimental studies in prediction of air pollution induced crop loss. Copyright 2009 Elsevier Ltd. All rights reserved.

  7. The impact of tropospheric ozone pollution on trial plot winter wheat yields in Great Britain - An econometric approach

    International Nuclear Information System (INIS)

    Kaliakatsou, Evridiki; Bell, J. Nigel B.; Thirtle, Colin; Rose, Daniel; Power, Sally A.

    2010-01-01

    Numerous experiments have demonstrated reductions in the yields of cereal crops due to tropospheric O 3 , with losses of up to 25%. However, the only British econometric study on O 3 impacts on winter wheat yields, found that a 10% increase in AOT40 would decrease yields by only 0.23%. An attempt is made here to reconcile these observations by developing AOT40 maps for Great Britain and matching levels with a large number of standardised trial plot wheat yields from many sites over a 13-year period. Panel estimates (repeated measures on the same plots with time) show a 0.54% decrease in yields and it is hypothesised that plant breeders may have inadvertently selected for O 3 tolerance in wheat. Some support for this is provided by fumigations of cultivars of differing introduction dates. A case is made for the use of econometric as well as experimental studies in prediction of air pollution induced crop loss. - Econometric study of British winter wheat trial plot data suggests lower economic loss than predicted from experiments.

  8. A comprehensive approach to formulation of seaweed-enriched meat products: From technological development to assessment of healthy properties.

    Science.gov (United States)

    Cofrades, S; Benedí, J; Garcimartin, A; Sánchez-Muniz, F J; Jimenez-Colmenero, F

    2017-09-01

    Meat consumption is influenced by various kinds of factors, among them health implications. Different strategies can be effective in developing meat-based functional foods. These basically entail reducing the presence of compounds with negative health implications and enhancing the presence of beneficial compounds. This article reviews a comprehensive model for the development of meat-based functional foods based on a presentation of the research achieved in terms of the design and development of qualitatively and quantitatively modified meat products (frankfurters, patties and restructured steaks). These were reformulated to incorporate nutrients associated with three different seaweeds (wakame-Undaria pinnatifida; nori-Porphyra umbilicalis; and sea spaghetti-Himanthalia elongata) as sources of bioactive substances, while simultaneously reducing sodium and fat and improving fatty acid profiles. Those seaweeds were chosen, because in terms of composition and health implications, abundance on Spanish coasts, relatively widespread consumption, and suitability in terms of flavour and colour they are better suited than others for use as ingredients in new products. It also discusses the consequences of the use of this type of meat-based functional foods (combination of pork meat and 5% of each seaweed with or without hypercholesterolaemic agent included in the diets) on growing animals (Wistar male rats), and their effects on different aspects of lipoprotein metabolism, oxidative stress and liver structure. This article, then, reports a comprehensive approach to the production of seaweed-enriched meat products, considering aspects of technological development aimed at achieving the functional effect. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. Do maize models capture the impacts of heat and drought stresses on yield? Using algorithm ensembles to identify successful approaches.

    Science.gov (United States)

    Jin, Zhenong; Zhuang, Qianlai; Tan, Zeli; Dukes, Jeffrey S; Zheng, Bangyou; Melillo, Jerry M

    2016-09-01

    Stresses from heat and drought are expected to increasingly suppress crop yields, but the degree to which current models can represent these effects is uncertain. Here we evaluate the algorithms that determine impacts of heat and drought stress on maize in 16 major maize models by incorporating these algorithms into a standard model, the Agricultural Production Systems sIMulator (APSIM), and running an ensemble of simulations. Although both daily mean temperature and daylight temperature are common choice of forcing heat stress algorithms, current parameterizations in most models favor the use of daylight temperature even though the algorithm was designed for daily mean temperature. Different drought algorithms (i.e., a function of soil water content, of soil water supply to demand ratio, and of actual to potential transpiration ratio) simulated considerably different patterns of water shortage over the growing season, but nonetheless predicted similar decreases in annual yield. Using the selected combination of algorithms, our simulations show that maize yield reduction was more sensitive to drought stress than to heat stress for the US Midwest since the 1980s, and this pattern will continue under future scenarios; the influence of excessive heat will become increasingly prominent by the late 21st century. Our review of algorithms in 16 crop models suggests that the impacts of heat and drought stress on plant yield can be best described by crop models that: (i) incorporate event-based descriptions of heat and drought stress, (ii) consider the effects of nighttime warming, and (iii) coordinate the interactions among multiple stresses. Our study identifies the proficiency with which different model formulations capture the impacts of heat and drought stress on maize biomass and yield production. The framework presented here can be applied to other modeled processes and used to improve yield predictions of other crops with a wide variety of crop models. © 2016 John

  10. Calculation of total free energy yield as an alternative approach for predicting the importance of potential chemolithotrophic reactions in geothermal springs.

    Science.gov (United States)

    Dodsworth, Jeremy A; McDonald, Austin I; Hedlund, Brian P

    2012-08-01

    To inform hypotheses regarding the relative importance of chemolithotrophic metabolisms in geothermal environments, we calculated free energy yields of 26 chemical reactions potentially supporting chemolithotrophy in two US Great Basin hot springs, taking into account the effects of changing reactant and product activities on the Gibbs free energy as each reaction progressed. Results ranged from 1.2 × 10(-5) to 3.6 J kg(-1) spring water, or 3.7 × 10(-5) to 11.5 J s(-1) based on measured flow rates, with aerobic oxidation of CH(4) or NH4 + giving the highest average yields. Energy yields calculated without constraining pH were similar to those at constant pH except for reactions where H(+) was consumed, which often had significantly lower yields when pH was unconstrained. In contrast to the commonly used normalization of reaction chemical affinities per mole of electrons transferred, reaction energy yields for a given oxidant varied by several orders of magnitude and were more sensitive to differences in the activities of products and reactants. The high energy yield of aerobic ammonia oxidation is consistent with previous observations of significant ammonia oxidation rates and abundant ammonia-oxidizing archaea in sediments of these springs. This approach offers an additional lens through which to view the thermodynamic landscape of geothermal springs. © 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.

  11. S-type and P-type habitability in stellar binary systems: A comprehensive approach. I. Method and applications

    Energy Technology Data Exchange (ETDEWEB)

    Cuntz, M., E-mail: cuntz@uta.edu [Department of Physics, University of Texas at Arlington, Arlington, TX 76019-0059 (United States)

    2014-01-01

    A comprehensive approach is provided for the study of both S-type and P-type habitability in stellar binary systems, which in principle can also be expanded to systems of higher order. P-type orbits occur when the planet orbits both binary components, whereas in the case of S-type orbits, the planet orbits only one of the binary components with the second component considered a perturbator. The selected approach encapsulates a variety of different aspects, which include: (1) the consideration of a joint constraint, including orbital stability and a habitable region for a putative system planet through the stellar radiative energy fluxes ({sup r}adiative habitable zone{sup ;} RHZ), needs to be met; (2) the treatment of conservative, general, and extended zones of habitability for the various systems as defined for the solar system and beyond; (3) the provision of a combined formalism for the assessment of both S-type and P-type habitability; in particular, mathematical criteria are presented for the kind of system in which S-type and P-type habitability is realized; (4) applications of the attained theoretical approach to standard (theoretical) main-sequence stars. In principle, five different cases of habitability are identified, which are S-type and P-type habitability provided by the full extent of the RHZs; habitability, where the RHZs are truncated by the additional constraint of planetary orbital stability (referred to as ST- and PT-type, respectively); and cases of no habitability at all. Regarding the treatment of planetary orbital stability, we utilize the formulae of Holman and Wiegert as also used in previous studies. In this work, we focus on binary systems in circular orbits. Future applications will also consider binary systems in elliptical orbits and provide thorough comparisons to other methods and results given in the literature.

  12. Plateletpheresis efficiency and mathematical correction of software-derived platelet yield prediction: A linear regression and ROC modeling approach.

    Science.gov (United States)

    Jaime-Pérez, José Carlos; Jiménez-Castillo, Raúl Alberto; Vázquez-Hernández, Karina Elizabeth; Salazar-Riojas, Rosario; Méndez-Ramírez, Nereida; Gómez-Almaguer, David

    2017-10-01

    Advances in automated cell separators have improved the efficiency of plateletpheresis and the possibility of obtaining double products (DP). We assessed cell processor accuracy of predicted platelet (PLT) yields with the goal of a better prediction of DP collections. This retrospective proof-of-concept study included 302 plateletpheresis procedures performed on a Trima Accel v6.0 at the apheresis unit of a hematology department. Donor variables, software predicted yield and actual PLT yield were statistically evaluated. Software prediction was optimized by linear regression analysis and its optimal cut-off to obtain a DP assessed by receiver operating characteristic curve (ROC) modeling. Three hundred and two plateletpheresis procedures were performed; in 271 (89.7%) occasions, donors were men and in 31 (10.3%) women. Pre-donation PLT count had the best direct correlation with actual PLT yield (r = 0.486. P Simple correction derived from linear regression analysis accurately corrected this underestimation and ROC analysis identified a precise cut-off to reliably predict a DP. © 2016 Wiley Periodicals, Inc.

  13. Equity yields

    NARCIS (Netherlands)

    Vrugt, E.; van Binsbergen, J.H.; Koijen, R.S.J.; Hueskes, W.

    2013-01-01

    We study a new data set of dividend futures with maturities up to ten years across three world regions: the US, Europe, and Japan. We use these asset prices to construct equity yields, analogous to bond yields. We decompose the equity yields to obtain a term structure of expected dividend growth

  14. Building a sustainable workforce in a rural and remote health service: A comprehensive and innovative Rural Generalist training approach.

    Science.gov (United States)

    Orda, Ulrich; Orda, Sabine; Sen Gupta, Tarun; Knight, Sabina

    2017-04-01

    Historically it has been challenging to recruit and retain an appropriately trained medical workforce to care for rural and remote Australians. This paper describes the Queensland North West Hospital and Health Service (NWHHS) workforce redesign, developing education strategies and pathways to practice, thereby improving service provision, recruitment and retention of staff. The Mount Isa-based Medical Education Unit sought accreditation for a Rural Generalist (RG) training pathway from Internship to Fellowship with the Australian College of Rural and Remote Medicine (ACRRM) and the Regional Training Provider (RTP). This approach enhanced the James Cook University (JCU) undergraduate pathway for rurally committed students while improving recruitment and retention of RMOs/Registrars. Accreditation was achieved through collaboration with training providers, accreditation agencies, ACRRM and a local general practice. The whole pathway from ignore Internship to Fellowship is offered with the RG Intern intake as a primary allocation site beginning in 2016. Comprehensive supervision and excellent clinical exposure provide an interesting and rewarding experience - for staff at all levels. Since 2013 RMO locum rates have been <1%. Registrars on the ACRRM pathway and Interns increased from 0 to 7 positions each in 2015, with similar achievements in SMO staffing. Three RMOs expressed interest in a Registrar position, CONCLUSIONS: Appropriate governance is needed to develop and advertise the program. This includes the NWHHS, the RG Pathway and JCU. © 2016 National Rural Health Alliance Inc.

  15. A comprehensive approach to handle the dynamics of customer’s needs in Quality Function Deployment based on linguistic variables

    Directory of Open Access Journals (Sweden)

    Zohreh Bostaki

    2014-04-01

    Full Text Available In the contexture of a customer-driven goods or service design process, a well-timed update of customer’s requirements may not only serve as a necessity indicator to observe how things change over time, but also it incorporates the firms a better ground to interoperate different strategies to meet the future needs of its customer. This paper proposes a systematic methodology to deal with the customer needs’ dynamics, in terms of their relative weights, in the QFD. Compared with previous research, the contribution of this paper is fourfold. First, it applies some linguistic variables to get preferences of customers and experts to determine the relative importance of customer requirements (CRs and the relationships between customer requirements and engineering characteristics (ECs. Second, it proposes the implementation of a forecasting technique. Third, it describes more comprehensively on how future uncertainty in the weights of customer’s needs could be estimated and transmitted into the design attributes. Fourth, it proposes the implementation of a quantitative approach, which takes into account the decision maker’s attitude towards risk to optimize the QFD decision making analysis. Finally, a real-world application of QFD is provided to demonstrate the practical applicability of the proposed methodology.

  16. S-TYPE AND P-TYPE HABITABILITY IN STELLAR BINARY SYSTEMS: A COMPREHENSIVE APPROACH. II. ELLIPTICAL ORBITS

    Energy Technology Data Exchange (ETDEWEB)

    Cuntz, M., E-mail: cuntz@uta.edu [Department of Physics, University of Texas at Arlington, Arlington, TX 76019-0059 (United States)

    2015-01-10

    In the first paper of this series, a comprehensive approach has been provided for the study of S-type and P-type habitable regions in stellar binary systems, which was, however, restricted to circular orbits of the stellar components. Fortunately, a modest modification of the method also allows for the consideration of elliptical orbits, which of course entails a much broader range of applicability. This augmented method is presented here, and numerous applications are conveyed. In alignment with Paper I, the selected approach considers a variety of aspects, which comprise the consideration of a joint constraint including orbital stability and a habitable region for a possible system planet through the stellar radiative energy fluxes ({sup r}adiative habitable zone{sup ;} RHZ). The devised method is based on a combined formalism for the assessment of both S-type and P-type habitability; in particular, mathematical criteria are deduced for which kinds of systems S-type and P-type habitable zones are realized. If the RHZs are truncated by the additional constraint of orbital stability, the notation of ST-type and PT-type habitability applies. In comparison to the circular case, it is found that in systems of higher eccentricity, the range of the RHZs is significantly reduced. Moreover, for a considerable number of models, the orbital stability constraint also reduces the range of S-type and P-type habitability. Nonetheless, S-, P-, ST-, and PT-type habitability is identified for a considerable set of system parameters. The method as presented is utilized for BinHab, an online code available at The University of Texas at Arlington.

  17. S-TYPE AND P-TYPE HABITABILITY IN STELLAR BINARY SYSTEMS: A COMPREHENSIVE APPROACH. II. ELLIPTICAL ORBITS

    International Nuclear Information System (INIS)

    Cuntz, M.

    2015-01-01

    In the first paper of this series, a comprehensive approach has been provided for the study of S-type and P-type habitable regions in stellar binary systems, which was, however, restricted to circular orbits of the stellar components. Fortunately, a modest modification of the method also allows for the consideration of elliptical orbits, which of course entails a much broader range of applicability. This augmented method is presented here, and numerous applications are conveyed. In alignment with Paper I, the selected approach considers a variety of aspects, which comprise the consideration of a joint constraint including orbital stability and a habitable region for a possible system planet through the stellar radiative energy fluxes ( r adiative habitable zone ; RHZ). The devised method is based on a combined formalism for the assessment of both S-type and P-type habitability; in particular, mathematical criteria are deduced for which kinds of systems S-type and P-type habitable zones are realized. If the RHZs are truncated by the additional constraint of orbital stability, the notation of ST-type and PT-type habitability applies. In comparison to the circular case, it is found that in systems of higher eccentricity, the range of the RHZs is significantly reduced. Moreover, for a considerable number of models, the orbital stability constraint also reduces the range of S-type and P-type habitability. Nonetheless, S-, P-, ST-, and PT-type habitability is identified for a considerable set of system parameters. The method as presented is utilized for BinHab, an online code available at The University of Texas at Arlington

  18. The Role of Strong Coupling in Z-Pinch-Driven Approaches to High Yield Inertial Confinement Fusion

    International Nuclear Information System (INIS)

    MEHLHORN, THOMAS A.; DESJARLAIS, MICHAEL P.; HAILL, THOMAS A.; LASH, JOEL S.; ROSENTHAL, STEPHEN E.; SLUTZ, STEPHEN A.; STOLTZ, PETER H.; VESEY, ROGER A.; OLIVER, B.

    1999-01-01

    Peak x-ray powers as high as 280 ± 40 TW have been generated from the implosion of tungsten wire arrays on the Z Accelerator at Sandia National Laboratories. The high x-ray powers radiated by these z-pinches provide an attractive new driver option for high yield inertial confinement fusion (ICF). The high x-ray powers appear to be a result of using a large number of wires in the array which decreases the perturbation seed to the magnetic Rayleigh-Taylor (MRT) instability and diminishes other 3-D effects. Simulations to confirm this hypothesis require a 3-D MHD code capability, and associated databases, to follow the evolution of the wires from cold solid through melt, vaporization, ionization, and finally to dense imploded plasma. Strong coupling plays a role in this process, the importance of which depends on the wire material and the current time history of the pulsed power driver. Strong coupling regimes are involved in the plasmas in the convolute and transmission line of the powerflow system. Strong coupling can also play a role in the physics of the z-pinch-driven high yield ICF target. Finally, strong coupling can occur in certain z-pinch-driven application experiments

  19. Issues at stake when considering long term storage of HLW. A comprehensive approach to designing the facility

    International Nuclear Information System (INIS)

    Marvy, A.; Ochem, D.

    2002-01-01

    CEA has been conducting a comprehensive R and D program to identify and study key HLW storage design criteria to possibly meet the lifetime goal of a century and beyond. A novel approach is being used since such installations must be understood as a global system comprised of various materials and hardware components, canisters, concrete and steel structures and specific procedures covering engineering steps from construction to operation including monitoring, care and maintenance as well as licensing. The challenge set by such a lifetime design goal made the R and D people focus on issues at stake and relevant to long term HLW storage in particular heat management, the effect of time on materials and the sustainability of care and maintenance. This opened up the R and D field from fundamental research areas to more conventional and technical aspects. Two major guiding principles have been devised as key design goals for the storage concepts under consideration. One is the paramount function of retrievability, which must allow the safe retrieval of any HLW package from the facility at any given time. Next is the passive containment philosophy requiring that a two-barrier system be considered. In the case of spent fuel, CEA's early assessment of the long-term behaviour of cladding shows that it cannot qualify as a reliable barrier over a long period of time. Therefore, the overriding strategy of preventing corrosion and material degradation to achieve canister protection, and therefore containment of radioactive material throughout the time of period envisaged, is at the heart of the R and D program and several design alternatives are being studied to meet that objective. For instance available thermal power from SF is used to establish dry corrosion conditions within the storage facility. The paper reviews all of these different R and D and engineering aspects. (author)

  20. RDS; A systematic approach towards system thermal hydraulics input code development for a comprehensive deterministic safety analysis

    International Nuclear Information System (INIS)

    Mohd Faiz Salim; Ridha Roslan; Mohd Rizal Mamat

    2013-01-01

    Full-text: Deterministic Safety Analysis (DSA) is one of the mandatory requirements conducted for Nuclear Power Plant licensing process, with the aim of ensuring safety compliance with relevant regulatory acceptance criteria. DSA is a technique whereby a set of conservative deterministic rules and requirements are applied for the design and operation of facilities or activities. Computer codes are normally used to assist in performing all required analysis under DSA. To ensure a comprehensive analysis, the conduct of DSA should follow a systematic approach. One of the methodologies proposed is the Standardized and Consolidated Reference Experimental (and Calculated) Database (SCRED) developed by University of Pisa. Based on this methodology, the use of Reference Data Set (RDS) as a pre-requisite reference document for developing input nodalization was proposed. This paper shall describe the application of RDS with the purpose of assessing its effectiveness. Two RDS documents were developed for an Integral Test Facility of LOBIMOD2 and associated Test A1-83. Data and information from various reports and drawings were referred in preparing the RDS. The results showed that by developing RDS, it has made possible to consolidate all relevant information in one single document. This is beneficial as it enables preservation of information, promotes quality assurance, allows traceability, facilitates continuous improvement, promotes solving of contradictions and finally assisting in developing thermal hydraulic input regardless of whichever code selected. However, some disadvantages were also recognized such as the need for experience in making engineering judgments, language barrier in accessing foreign information and limitation of resources. Some possible improvements are suggested to overcome these challenges. (author)

  1. RDS - A systematic approach towards system thermal hydraulics input code development for a comprehensive deterministic safety analysis

    International Nuclear Information System (INIS)

    Salim, Mohd Faiz; Roslan, Ridha; Ibrahim, Mohd Rizal Mamat

    2014-01-01

    Deterministic Safety Analysis (DSA) is one of the mandatory requirements conducted for Nuclear Power Plant licensing process, with the aim of ensuring safety compliance with relevant regulatory acceptance criteria. DSA is a technique whereby a set of conservative deterministic rules and requirements are applied for the design and operation of facilities or activities. Computer codes are normally used to assist in performing all required analysis under DSA. To ensure a comprehensive analysis, the conduct of DSA should follow a systematic approach. One of the methodologies proposed is the Standardized and Consolidated Reference Experimental (and Calculated) Database (SCRED) developed by University of Pisa. Based on this methodology, the use of Reference Data Set (RDS) as a pre-requisite reference document for developing input nodalization was proposed. This paper shall describe the application of RDS with the purpose of assessing its effectiveness. Two RDS documents were developed for an Integral Test Facility of LOBI-MOD2 and associated Test A1-83. Data and information from various reports and drawings were referred in preparing the RDS. The results showed that by developing RDS, it has made possible to consolidate all relevant information in one single document. This is beneficial as it enables preservation of information, promotes quality assurance, allows traceability, facilitates continuous improvement, promotes solving of contradictions and finally assisting in developing thermal hydraulic input regardless of whichever code selected. However, some disadvantages were also recognized such as the need for experience in making engineering judgments, language barrier in accessing foreign information and limitation of resources. Some possible improvements are suggested to overcome these challenges

  2. RDS - A systematic approach towards system thermal hydraulics input code development for a comprehensive deterministic safety analysis

    Energy Technology Data Exchange (ETDEWEB)

    Salim, Mohd Faiz, E-mail: mohdfaizs@tnb.com.my [Nuclear Energy Department, Tenaga Nasional Berhad, Level 32, Dua Sentral, 50470 Kuala Lumpur (Malaysia); Roslan, Ridha [Nuclear Installation Division, Atomic Energy Licensing Board, Batu 24, Jalan Dengkil, 43800 Dengkil, Selangor (Malaysia); Ibrahim, Mohd Rizal Mamat [Technical Support Division, Malaysian Nuclear Agency, Bangi, 43000 Kajang, Selangor (Malaysia)

    2014-02-12

    Deterministic Safety Analysis (DSA) is one of the mandatory requirements conducted for Nuclear Power Plant licensing process, with the aim of ensuring safety compliance with relevant regulatory acceptance criteria. DSA is a technique whereby a set of conservative deterministic rules and requirements are applied for the design and operation of facilities or activities. Computer codes are normally used to assist in performing all required analysis under DSA. To ensure a comprehensive analysis, the conduct of DSA should follow a systematic approach. One of the methodologies proposed is the Standardized and Consolidated Reference Experimental (and Calculated) Database (SCRED) developed by University of Pisa. Based on this methodology, the use of Reference Data Set (RDS) as a pre-requisite reference document for developing input nodalization was proposed. This paper shall describe the application of RDS with the purpose of assessing its effectiveness. Two RDS documents were developed for an Integral Test Facility of LOBI-MOD2 and associated Test A1-83. Data and information from various reports and drawings were referred in preparing the RDS. The results showed that by developing RDS, it has made possible to consolidate all relevant information in one single document. This is beneficial as it enables preservation of information, promotes quality assurance, allows traceability, facilitates continuous improvement, promotes solving of contradictions and finally assisting in developing thermal hydraulic input regardless of whichever code selected. However, some disadvantages were also recognized such as the need for experience in making engineering judgments, language barrier in accessing foreign information and limitation of resources. Some possible improvements are suggested to overcome these challenges.

  3. Toward a comprehensive approach to the collection and analysis of pica substances, with emphasis on geophagic materials.

    Directory of Open Access Journals (Sweden)

    Sera L Young

    2008-09-01

    Full Text Available Pica, the craving and subsequent consumption of non-food substances such as earth, charcoal, and raw starch, has been an enigma for more than 2000 years. Currently, there are little available data for testing major hypotheses about pica because of methodological limitations and lack of attention to the problem.In this paper we critically review procedures and guidelines for interviews and sample collection that are appropriate for a wide variety of pica substances. In addition, we outline methodologies for the physical, mineralogical, and chemical characterization of these substances, with particular focus on geophagic soils and clays. Many of these methods are standard procedures in anthropological, soil, or nutritional sciences, but have rarely or never been applied to the study of pica.Physical properties of geophagic materials including color, particle size distribution, consistency and dispersion/flocculation (coagulation should be assessed by appropriate methods. Quantitative mineralogical analyses by X-ray diffraction should be made on bulk material as well as on separated clay fractions, and the various clay minerals should be characterized by a variety of supplementary tests. Concentrations of minerals should be determined using X-ray fluorescence for non-food substances and inductively coupled plasma-atomic emission spectroscopy for food-like substances. pH, salt content, cation exchange capacity, organic carbon content and labile forms of iron oxide should also be determined. Finally, analyses relating to biological interactions are recommended, including determination of the bioavailability of nutrients and other bioactive components from pica substances, as well as their detoxification capacities and parasitological profiles.This is the first review of appropriate methodologies for the study of human pica. The comprehensive and multi-disciplinary approach to the collection and analysis of pica substances detailed here is a necessary

  4. Establishing a Commercial Buildings Energy Data Framework for India: A Comprehensive Look at Data Collection Approaches, Use Cases and Institutions

    Energy Technology Data Exchange (ETDEWEB)

    Iyer, Maithili [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Kumar, Satish [Synurja, LLC, Vienna, VA (United States); Mathew, Sangeeta [Synurja, LLC, Vienna, VA (United States); Stratton, Hannah [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Mathew, Paul [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Singh, Mohini [Synurja, LLC, Vienna, VA (United States)

    2016-10-01

    Enhancing energy efficiency of the commercial building stock is an important aspect of any national energy policy. Understanding how buildings use energy is critical to formulating any new policy that may impact energy use, underscoring the importance of credible data. Data enables informed decision making and good quality data is essential for policy makers to prioritize energy saving strategies and track implementation. Given the uniqueness of the buildings sector and challenges to collecting relevant energy data, this study characterizes various elements involved in pertinent data collection and management, with the specific focus on well-defined data requirements, appropriate methodologies and processes, feasible data collection mechanisms, and approaches to institutionalizing the collection process. This report starts with a comprehensive review of available examples of energy data collection frameworks for buildings across different countries. The review covers the U.S. experience in the commercial buildings sector, the European experience in the buildings sector and other data collection initiatives in Singapore and China to capture the more systematic efforts in Asia in the commercial sector. To provide context, the review includes a summary and status of disparate efforts in India to collect and use commercial building energy data. Using this review as a key input, the study developed a data collection framework for India with specific consideration to relevant use cases. Continuing with the framework for data collection, this study outlines the key performance indicators applicable to the use cases and their collection feasibility, as well as immediate priorities of the participating stakeholders. It also discusses potential considerations for data collection and the possible approaches for survey design. With the specific purpose of laying out the possible ways to structure and organize data collection institutionally, the study collates existing

  5. Selection for high oridonin yield in the Chinese medicinal plant Isodon (Lamiaceae using a combined phylogenetics and population genetics approach.

    Directory of Open Access Journals (Sweden)

    Eric S J Harris

    Full Text Available Oridonin is a diterpenoid with anti-cancer activity that occurs in the Chinese medicinal plant Isodon rubescens and some related species. While the bioactivity of oridonin has been well studied, the extent of natural variation in the production of this compound is poorly known. This study characterizes natural variation in oridonin production in order to guide selection of populations of Isodon with highest oridonin yield. Different populations of I. rubescens and related species were collected in China, and their offspring were grown in a greenhouse. Samples were examined for oridonin content, genotyped using 11 microsatellites, and representatives were sequenced for three phylogenetic markers (ITS, rps16, trnL-trnF. Oridonin production was mapped on a molecular phylogeny of the genus Isodon using samples from each population as well as previously published Genbank sequences. Oridonin has been reported in 12 out of 74 species of Isodon examined for diterpenoids, and the phylogeny indicates that oridonin production has arisen at least three times in the genus. Oridonin production was surprisingly consistent between wild-collected parents and greenhouse-grown offspring, despite evidence of gene flow between oridonin-producing and non-producing populations of Isodon. Additionally, microsatellite genetic distance between individuals was significantly correlated with chemical distance in both parents and offspring. Neither heritability nor correlation with genetic distance were significant when the comparison was restricted to only populations of I. rubescens, but this result should be corroborated using additional samples. Based on these results, future screening of Isodon populations for oridonin yield should initially prioritize a broad survey of all species known to produce oridonin, rather than focusing on multiple populations of one species, such as I. rubescens. Of the samples examined here, I. rubescens or I. japonicus from Henan province

  6. Impact Of Using Joint Productive Activity Approach On Second Language Learners’ Performance In Reading Comprehension At The Basic Education Level In Nigeria

    Directory of Open Access Journals (Sweden)

    HANNA ONYI YUSUF

    2013-01-01

    Full Text Available This study investigated the impact of using joint productive activity on the performance of second language learners in reading comprehension at the basic education level in Nigeria. A sample of forty (40 Junior Secondary II students from Kaduna North and South were used for the study. The study was quasi experimental. Government Junior Secondary School Doka was used as the experimental group while Government Junior Secondary School Makera was used as the control group. Both groups were assessed after six weeks of teaching using two reading comprehension tests. T-test was used to test the hypothesis raised in the study. The findings revealed significant differences in the performance of students taught reading comprehension using joint productive activity. Based on the findings teachers are encouraged to use joint productive activities in teaching reading comprehension. This is a positive deviation from the traditional practice in Nigeria where a teacher is regarded as the sole custodian of knowledge and students are empty tabula rasa who should be passive during class teaching. Teachers need to exploit this new approach by designing teaching comprehension activities that will require second language learners’ collaboration and active participation in accomplishing tasks jointly in class with the teacher.

  7. Multidisciplinary team-based approach for comprehensive preoperative pulmonary rehabilitation including intensive nutritional support for lung cancer patients.

    Directory of Open Access Journals (Sweden)

    Hiroaki Harada

    Full Text Available BACKGROUND: To decrease the risk of postoperative complication, improving general and pulmonary conditioning preoperatively should be considered essential for patients scheduled to undergo lung surgery. OBJECTIVE: The aim of this study is to develop a short-term beneficial program of preoperative pulmonary rehabilitation for lung cancer patients. METHODS: From June 2009, comprehensive preoperative pulmonary rehabilitation (CHPR including intensive nutritional support was performed prospectively using a multidisciplinary team-based approach. Postoperative complication rate and the transitions of pulmonary function in CHPR were compared with historical data of conventional preoperative pulmonary rehabilitation (CVPR conducted since June 2006. The study population was limited to patients who underwent standard lobectomy. RESULTS: Postoperative complication rate in the CVPR (n = 29 and CHPR (n = 21 were 48.3% and 28.6% (p = 0.2428, respectively. Those in patients with Charlson Comorbidity Index scores ≥2 were 68.8% (n = 16 and 27.3% (n = 11, respectively (p = 0.0341 and those in patients with preoperative risk score in Estimation of Physiologic Ability and Surgical Stress scores >0.3 were 57.9% (n = 19 and 21.4% (n = 14, respectively (p = 0.0362. Vital capacities of pre- and post intervention before surgery in the CHPR group were 2.63±0.65 L and 2.75±0.63 L (p = 0.0043, respectively; however, their transition in the CVPR group was not statistically significant (p = 0.6815. Forced expiratory volumes in one second of pre- and post intervention before surgery in the CHPR group were 1.73±0.46 L and 1.87±0.46 L (p = 0.0012, respectively; however, their transition in the CVPR group was not statistically significant (p = 0.6424. CONCLUSIONS: CHPR appeared to be a beneficial and effective short-term preoperative rehabilitation protocol, especially in patients with poor preoperative conditions.

  8. Multidisciplinary team-based approach for comprehensive preoperative pulmonary rehabilitation including intensive nutritional support for lung cancer patients.

    Science.gov (United States)

    Harada, Hiroaki; Yamashita, Yoshinori; Misumi, Keizo; Tsubokawa, Norifumi; Nakao, Junichi; Matsutani, Junko; Yamasaki, Miyako; Ohkawachi, Tomomi; Taniyama, Kiyomi

    2013-01-01

    To decrease the risk of postoperative complication, improving general and pulmonary conditioning preoperatively should be considered essential for patients scheduled to undergo lung surgery. The aim of this study is to develop a short-term beneficial program of preoperative pulmonary rehabilitation for lung cancer patients. From June 2009, comprehensive preoperative pulmonary rehabilitation (CHPR) including intensive nutritional support was performed prospectively using a multidisciplinary team-based approach. Postoperative complication rate and the transitions of pulmonary function in CHPR were compared with historical data of conventional preoperative pulmonary rehabilitation (CVPR) conducted since June 2006. The study population was limited to patients who underwent standard lobectomy. Postoperative complication rate in the CVPR (n = 29) and CHPR (n = 21) were 48.3% and 28.6% (p = 0.2428), respectively. Those in patients with Charlson Comorbidity Index scores ≥2 were 68.8% (n = 16) and 27.3% (n = 11), respectively (p = 0.0341) and those in patients with preoperative risk score in Estimation of Physiologic Ability and Surgical Stress scores >0.3 were 57.9% (n = 19) and 21.4% (n = 14), respectively (p = 0.0362). Vital capacities of pre- and post intervention before surgery in the CHPR group were 2.63±0.65 L and 2.75±0.63 L (p = 0.0043), respectively; however, their transition in the CVPR group was not statistically significant (p = 0.6815). Forced expiratory volumes in one second of pre- and post intervention before surgery in the CHPR group were 1.73±0.46 L and 1.87±0.46 L (p = 0.0012), respectively; however, their transition in the CVPR group was not statistically significant (p = 0.6424). CHPR appeared to be a beneficial and effective short-term preoperative rehabilitation protocol, especially in patients with poor preoperative conditions.

  9. An innovative approach for Predicting Farmers' Adaptive Behavior at the Large Watershed Scale: Implications for Water Quality and Crop Yields

    Science.gov (United States)

    Valcu-Lisman, A. M.; Gassman, P. W.; Arritt, R. W.; Kling, C.; Arbuckle, J. G.; Roesch-McNally, G. E.; Panagopoulos, Y.

    2017-12-01

    Projected changes in the climatic patterns (higher temperatures, changes in extreme precipitation events, and higher levels of humidity) will affect agricultural cropping and management systems in major agricultural production areas. The concept of adaption to new climatic or economic conditions is an important aspect of the agricultural decision-making process. Adopting cover crops, reduced tillage, extending the drainage systems and adjusting crop management are only a few examples of adaptive actions. These actions can be easily implemented as long as they have private benefits (increased profits, reduced risk). However, each adaptive action has a different impact on water quality. Cover crops and no till usually have a positive impact on water quality, but increased tile drainage typically results in more degraded water quality due primarily to increased export of soluble nitrogen and phosphorus. The goal of this research is to determine the changes in water quality as well in crop yields as farmers undertake these adaptive measures. To answer this research question, we need to estimate the likelihood that these actions will occur, identify the agricultural areas where these actions are most likely to be implemented, and simulate the water quality impacts associated with each of these scenarios. We apply our modeling efforts to the whole Upper-Mississippi River Basin Basin (UMRB) and the Ohio-Tennessee River Basin (OTRB). These two areas are critical source regions for the re-occurring hypoxic zone in the gulf of Mexico. The likelihood of each adaptive agricultural action is estimated using data from a survey conducted in 2012. A large, representative sample of farmers in the Corn Belt was used in the survey to elicit behavioral intentions regarding three of the most important agricultural adaptation strategies (no-till, cover crops and tile drainage). We use these data to study the relationship between intent to adapt, farmer characteristics, farm

  10. A comprehensive approach in high-grade glioma management: position statement from the Neuro-Oncology Scientific Club (NOSC), Shiraz, Iran

    OpenAIRE

    Ansari, Mansour; Mosalaei, Ahmad; Ahmadloo, Niloufar; Rasekhi, Alireza; Geramizadeh, Bita; Razmkon, Ali; Anvari, Kazem; Afarid, Mohammad; Dadras, Ali; Nafarieh, Leila; Mohammadianpanah, Mohammad; Nasrolahi, Hamid; Hamedi, Seyed Hasan; Omidvari, Shapour; Nami, Mohammad

    2017-01-01

    Establishing a robust teamwork model in the practice of neuro-oncology requires continued interdisciplinary efforts. The Neuro-Oncology Scientific Club (NOSC) initiative is an interdisciplinary clinical forum promoting the comprehensive approach across involved disciplines in the management of central nervous system (CNS) malignancies. With its provincial founding panels and national steering board, NOSC has been operational in Iran since 2011. This initiative has pursued its mission through ...

  11. A combined neural network and mechanistic approach for the prediction of corrosion rate and yield strength of magnesium-rare earth alloys

    Energy Technology Data Exchange (ETDEWEB)

    Birbilis, N., E-mail: nick.birbilis@monash.ed [ARC Centre of Excellence for Design in Light Metals, Monash University (Australia); CAST Co-operative Research Centre, Monash University (Australia); Cavanaugh, M.K. [Department of Materials Science and Engineering, The Ohio State University (United States); Sudholz, A.D. [ARC Centre of Excellence for Design in Light Metals, Monash University (Australia); Zhu, S.M.; Easton, M.A. [CAST Co-operative Research Centre, Monash University (Australia); Gibson, M.A. [CSIRO Division of Process Science and Engineering (Australia)

    2011-01-15

    Research highlights: This study presents a body of corrosion data for a set of custom alloys and displays this in multivariable space. These alloys represent the next generation of Mg alloys for auto applications. The data is processed using an ANN model, which makes it possible to yield a single expression for prediction of corrosion rate (and strength) as a function of any input composition (of Ce, La or Nd between 0 and 6 wt.%). The relative influence of the various RE elements on corrosion is assessed, with the outcome that Nd additions can offer comparable strength with minimal rise in corrosion rate. The morphology and solute present in the eutectic region itself (as opposed to just the intermetallic presence) was shown - for the first time - to also be a key contributor to corrosion. The above approach sets the foundation for rational alloy design of alloys with corrosion performance in mind. - Abstract: Additions of Ce, La and Nd to Mg were made in binary, ternary and quaternary combinations up to {approx}6 wt.%. This provided a dataset that was used in developing a neural network model for predicting corrosion rate and yield strength. Whilst yield strength increased with RE additions, corrosion rates also systematically increased, however, this depended on the type of RE element added and the combination of elements added (along with differences in intermetallic morphology). This work is permits an understanding of Mg-RE alloy performance, and can be exploited in Mg alloy design for predictable combinations of strength and corrosion resistance.

  12. Investigating Predictors of Listening Comprehension in Third-, Seventh-, and Tenth-Grade Students: A Dominance Analysis Approach

    Science.gov (United States)

    Tighe, Elizabeth L.; Spencer, Mercedes; Schatschneider, Christopher

    2015-01-01

    This study rank ordered the contributive importance of several predictors of listening comprehension for third, seventh, and tenth graders. Principal components analyses revealed that a three-factor solution with fluency, reasoning, and working memory components provided the best fit across grade levels. Dominance analyses indicated that fluency…

  13. Teaching the Indirect Method of the Statement of Cash Flows in Introductory Financial Accounting: A Comprehensive, Problem-Based Approach

    Science.gov (United States)

    Brickner, Daniel R.; McCombs, Gary B.

    2004-01-01

    In this article, the authors provide an instructional resource for presenting the indirect method of the statement of cash flows (SCF) in an introductory financial accounting course. The authors focus primarily on presenting a comprehensive example that illustrates the "why" of SCF preparation and show how journal entries and T-accounts can be…

  14. An Automatic Caption Filtering and Partial Hiding Approach to Improving the English Listening Comprehension of EFL Students

    Science.gov (United States)

    Hsu, Ching-Kun; Hwang, Gwo-Jen; Chang, Chih-Kai

    2014-01-01

    Fostering the listening comprehension of English as Foreign Language (EFL) learners has been recognized as an important and challenging issue. Videos have been used as one of the English listening learning resources; however, without effective learning supports, EFL students are likely to encounter difficulties in comprehending the video content,…

  15. An in-depth mixed-methods approach to Ryan White HIV/AIDS care program comprehensive needs assessment from the Northeast Georgia Public Health District: the significance of patient privacy, psychological health, and social stigma to care.

    Science.gov (United States)

    Huff, Amber; Chumbler, Neale; Cherry, Colleen O'Brien; Hill, Miranda; Veguilla, Vic

    2015-04-01

    We apply a social-ecological interpretive framework to understanding relationships among patient privacy, psychological health, social stigma, and continuity in care in the HIV treatment cascade in the rural southeastern US. This research was conducted as part of the 2013 comprehensive needs assessment for the Northeast Georgia Ryan White Consortium using an anthropologically informed mixed-methods design, and a deductive-inductive approach to thematic analysis of qualitative data obtained in interviews and focus groups with service providers and service utilizers. Our comprehensive needs assessment yielded two key components. First, we identified salient phenomena influencing introduction to, retention among, and satisfaction of patients in the Ryan White-coordinated treatment cascade in NE-GA. Second, we formulated actionable recommendations around leverage points identified in the current district-wide system of care. Results highlight spatial, institutional, and interpersonal aspects of the system of care that intersect around issues of patient privacy, psychological health, and social stigma. These intersections constitute pathways by which persons living with HIV are exposed to stigma and other negative social signals regarding their health status without sufficient access to behavioral health services. These negative issues, in turn, can erect significant barriers to long-term continuity in care. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. Effect of yield to tensile (Y/T) ratio on the structural integrity of offshore pipeline: advanced engineering assessment using limit state design approach

    Energy Technology Data Exchange (ETDEWEB)

    Malatesta, G; Mannucci, G; Demofonti, G [Centro Sviluppo Materiali S.p.A., Rome (Italy); Cumino, G [TenarisDalmine (Italy); Izquierdo, A; Tivelli, M [Tenaris Group (Mexico); Quintanilla, H [TENARIS Group (Mexico). TAMSA

    2005-07-01

    Nowadays specifications require strict Yield to Tensile ratio limitation, nevertheless a fully accepted engineering assessment of its influence on pipeline integrity is still lacking. Probabilistic analysis based on structural reliability approach (Limit State Design) aimed at quantifying the Y/T ratio influence on failure probabilities of offshore pipelines was made. In particular, Tenaris seamless pipe data were used as input for the probabilistic failure analysis. The LSD approach has been applied to two actual deep water design cases that have been on purpose selected, and the most relevant failure modes have been considered. Main result of the work is that the quantitative effect of the Y/T ratio on failure probabilities of a deep water pipeline resulted not so big as expected; it has a minor effect, especially when failure modes are governed by Y only. (author)

  17. Using a Lean Six Sigma Approach to Yield Sustained Pressure Ulcer Prevention for Complex Critical Care Patients.

    Science.gov (United States)

    Donovan, Elizabeth A; Manta, Christine J; Goldsack, Jennifer C; Collins, Michelle L

    2016-01-01

    Under value-based purchasing, Medicare withholds reimbursements for hospital-acquired pressure ulcer occurrence and rewards hospitals that meet performance standards. With little evidence of a validated prevention process, nurse managers are challenged to find evidence-based interventions. The aim of this study was to reduce the unit-acquired pressure ulcer (UAPU) rate on targeted intensive care and step-down units by 15% using Lean Six Sigma (LSS) methodology. An interdisciplinary team designed a pilot program using LSS methodology to test 4 interventions: standardized documentation, equipment monitoring, patient out-of-bed-to-chair monitoring, and a rounding checklist. During the pilot, the UAPU rate decreased from 4.4% to 2.8%, exceeding the goal of a 15% reduction. The rate remained below the goal through the program control phase at 2.9%, demonstrating a statistically significant reduction after intervention implementation. The program significantly reduced UAPU rates in high-risk populations. LSS methodologies are a sustainable approach to reducing hospital-acquired conditions that should be broadly tested and implemented.

  18. An Anti-proteome Nanobody Library Approach Yields a Specific Immunoassay for Trypanosoma congolense Diagnosis Targeting Glycosomal Aldolase.

    Directory of Open Access Journals (Sweden)

    Steven Odongo

    2016-02-01

    Full Text Available Infectious diseases pose a severe worldwide threat to human and livestock health. While early diagnosis could enable prompt preventive interventions, the majority of diseases are found in rural settings where basic laboratory facilities are scarce. Under such field conditions, point-of-care immunoassays provide an appropriate solution for rapid and reliable diagnosis. The limiting steps in the development of the assay are the identification of a suitable target antigen and the selection of appropriate high affinity capture and detection antibodies. To meet these challenges, we describe the development of a Nanobody (Nb-based antigen detection assay generated from a Nb library directed against the soluble proteome of an infectious agent. In this study, Trypanosoma congolense was chosen as a model system.An alpaca was vaccinated with whole-parasite soluble proteome to generate a Nb library from which the most potent T. congolense specific Nb sandwich immunoassay (Nb474H-Nb474B was selected. First, the Nb474-homologous sandwich ELISA (Nb474-ELISA was shown to detect experimental infections with high Positive Predictive Value (98%, Sensitivity (87% and Specificity (94%. Second, it was demonstrated under experimental conditions that the assay serves as test-of-cure after Berenil treatment. Finally, this assay allowed target antigen identification. The latter was independently purified through immuno-capturing from (i T. congolense soluble proteome, (ii T. congolense secretome preparation and (iii sera of T. congolense infected mice. Subsequent mass spectrometry analysis identified the target as T. congolense glycosomal aldolase.The results show that glycosomal aldolase is a candidate biomarker for active T. congolense infections. In addition, and by proof-of-principle, the data demonstrate that the Nb strategy devised here offers a unique approach to both diagnostic development and target discovery that could be widely applied to other infectious

  19. A BioDesign Approach to Obtain High Yields of Biosimilars by Anti-apoptotic Cell Engineering: a Case Study to Increase the Production Yield of Anti-TNF Alpha Producing Recombinant CHO Cells.

    Science.gov (United States)

    Gulce Iz, Sultan; Inevi, Muge Anil; Metiner, Pelin Saglam; Tamis, Duygu Ayyildiz; Kisbet, Nazli

    2018-01-01

    Recent developments in medical biotechnology have facilitated to enhance the production of monoclonal antibodies (mAbs) and recombinant proteins in mammalian cells. Human mAbs for clinical applications have focused on three areas, particularly cancer, immunological disorders, and infectious diseases. Tumor necrosis factor alpha (TNF-α), which has both proinflammatory and immunoregulatory functions, is an important target in biopharmaceutical industry. In this study, a humanized anti-TNF-α mAb producing stable CHO cell line which produces a biosimilar of Humira (adalimumab) was used. Adalimumab is a fully human anti-TNF mAb among the top-selling mAb products in recent years as a biosimilar. Products from mammalian cell bioprocesses are a derivative of cell viability and metabolism, which is mainly disrupted by cell death in bioreactors. Thus, different strategies are used to increase the product yield. Suppression of apoptosis, also called anti-apoptotic cell engineering, is the most remarkable strategy to enhance lifetime of cells for a longer production period. In fact, using anti-apoptotic cell engineering as a BioDesign approach was inspired by nature; nature gives prolonged life span to some cells like stem cells, tumor cells, and memory B and T cells, and researchers have been using this strategy for different purposes. In this study, as a biomimicry approach, anti-apoptotic cell engineering was used to increase the anti-TNF-α mAb production from the humanized anti-TNF-α mAb producing stable CHO cell line by Bcl-xL anti-apoptotic protein. It was shown that transient transfection of CHO cells by the Bcl-xL anti-apoptotic protein expressing plasmid prolonged the cell survival rate and protected cells from apoptosis. The transient expression of Bcl-xL using CHO cells enhanced the anti-TNF-α production. The production of anti-TNF-α in CHO cells was increased up to 215 mg/L with an increase of 160% after cells were transfected with Bcl-xL expressing plasmid

  20. Investigation of Water Dynamics and the Effect of Evapotranspiration on Grain Yield of Rainfed Wheat and Barley under a Mediterranean Environment: A Modelling Approach.

    Science.gov (United States)

    Zhang, Kefeng; Bosch-Serra, Angela D; Boixadera, Jaume; Thompson, Andrew J

    2015-01-01

    Agro-hydrological models have increasingly become useful and powerful tools in optimizing water and fertilizer application, and in studying the environmental consequences. Accurate prediction of water dynamics in such models is essential for models to produce reasonable results. In this study, detailed simulations were performed for water dynamics of rainfed winter wheat and barley grown under a Mediterranean climate over a 10-year period. The model employed (Yang et al., 2009. J. Hydrol., 370, 177-190) uses easily available agronomic data, and takes into consideration of all key soil and plant processes in controlling water dynamics in the soil-crop system, including the dynamics of root growth. The water requirement for crop growth was calculated according to the FAO56, and the soil hydraulic properties were estimated using peto-transfer functions (PTFs) based on soil physical properties and soil organic matter content. Results show that the simulated values of soil water content at the depths of 15, 45 and 75 cm agreed with the measurements well with the root of the mean squared errors of 0.027 cm(3) cm(-3) and the model agreement index of 0.875. The simulated seasonal evapotranspiration (ET) ranged from 208 to 388 mm, and grain yield was found to correlate with the simulated seasonal ET in a linear manner within the studied ET range. The simulated rates of grain yield increase were 17.3 and 23.7 kg ha(-l) for every mm of water evapotranspired for wheat and barley, respectively. The good agreement of soil water content between measurement and simulation and the simulated relationships between grain yield and seasonal ET supported by the data in the literature indicates that the model performed well in modelling water dynamics for the studied soil-crop system, and therefore has the potential to be applied reliably and widely in precision agriculture. Finally, a two-staged approach using inverse modelling techniques to further improve model performance was

  1. A combined neural network and mechanistic approach for the prediction of corrosion rate and yield strength of magnesium-rare earth alloys

    International Nuclear Information System (INIS)

    Birbilis, N.; Cavanaugh, M.K.; Sudholz, A.D.; Zhu, S.M.; Easton, M.A.; Gibson, M.A.

    2011-01-01

    Research highlights: → This study presents a body of corrosion data for a set of custom alloys and displays this in multivariable space. These alloys represent the next generation of Mg alloys for auto applications. → The data is processed using an ANN model, which makes it possible to yield a single expression for prediction of corrosion rate (and strength) as a function of any input composition (of Ce, La or Nd between 0 and 6 wt.%). → The relative influence of the various RE elements on corrosion is assessed, with the outcome that Nd additions can offer comparable strength with minimal rise in corrosion rate. → The morphology and solute present in the eutectic region itself (as opposed to just the intermetallic presence) was shown - for the first time - to also be a key contributor to corrosion. → The above approach sets the foundation for rational alloy design of alloys with corrosion performance in mind. - Abstract: Additions of Ce, La and Nd to Mg were made in binary, ternary and quaternary combinations up to ∼6 wt.%. This provided a dataset that was used in developing a neural network model for predicting corrosion rate and yield strength. Whilst yield strength increased with RE additions, corrosion rates also systematically increased, however, this depended on the type of RE element added and the combination of elements added (along with differences in intermetallic morphology). This work is permits an understanding of Mg-RE alloy performance, and can be exploited in Mg alloy design for predictable combinations of strength and corrosion resistance.

  2. A comprehensive approach to improving patient flow in our hospitals--the 'left to right, over and under' concept.

    Science.gov (United States)

    Ardagh, Michael

    2015-08-21

    It is essential we manage the capacity of our hospitals so that acute demand can be accommodated without developing queues for care and backlogs of work. This paper presents a comprehensive model for improving patient flow in our hospitals by attending carefully to both the demand and capacity states of the hospital and maximising efficient flow of our acute patient journeys. The model includes attention to the patient journey as the central focus, with an overarching governance structure and an underpinning sophisticated operations structure.

  3. A Comprehensive Quality Evaluation System for Complex Herbal Medicine Using PacBio Sequencing, PCR-Denaturing Gradient Gel Electrophoresis, and Several Chemical Approaches

    Science.gov (United States)

    Zheng, Xiasheng; Zhang, Peng; Liao, Baosheng; Li, Jing; Liu, Xingyun; Shi, Yuhua; Cheng, Jinle; Lai, Zhitian; Xu, Jiang; Chen, Shilin

    2017-01-01

    Herbal medicine is a major component of complementary and alternative medicine, contributing significantly to the health of many people and communities. Quality control of herbal medicine is crucial to ensure that it is safe and sound for use. Here, we investigated a comprehensive quality evaluation system for a classic herbal medicine, Danggui Buxue Formula, by applying genetic-based and analytical chemistry approaches to authenticate and evaluate the quality of its samples. For authenticity, we successfully applied two novel technologies, third-generation sequencing and PCR-DGGE (denaturing gradient gel electrophoresis), to analyze the ingredient composition of the tested samples. For quality evaluation, we used high performance liquid chromatography assays to determine the content of chemical markers to help estimate the dosage relationship between its two raw materials, plant roots of Huangqi and Danggui. A series of surveys were then conducted against several exogenous contaminations, aiming to further access the efficacy and safety of the samples. In conclusion, the quality evaluation system demonstrated here can potentially address the authenticity, quality, and safety of herbal medicines, thus providing novel insight for enhancing their overall quality control. Highlight: We established a comprehensive quality evaluation system for herbal medicine, by combining two genetic-based approaches third-generation sequencing and DGGE (denaturing gradient gel electrophoresis) with analytical chemistry approaches to achieve the authentication and quality connotation of the samples. PMID:28955365

  4. A Comprehensive Quality Evaluation System for Complex Herbal Medicine Using PacBio Sequencing, PCR-Denaturing Gradient Gel Electrophoresis, and Several Chemical Approaches

    Directory of Open Access Journals (Sweden)

    Xiasheng Zheng

    2017-09-01

    Full Text Available Herbal medicine is a major component of complementary and alternative medicine, contributing significantly to the health of many people and communities. Quality control of herbal medicine is crucial to ensure that it is safe and sound for use. Here, we investigated a comprehensive quality evaluation system for a classic herbal medicine, Danggui Buxue Formula, by applying genetic-based and analytical chemistry approaches to authenticate and evaluate the quality of its samples. For authenticity, we successfully applied two novel technologies, third-generation sequencing and PCR-DGGE (denaturing gradient gel electrophoresis, to analyze the ingredient composition of the tested samples. For quality evaluation, we used high performance liquid chromatography assays to determine the content of chemical markers to help estimate the dosage relationship between its two raw materials, plant roots of Huangqi and Danggui. A series of surveys were then conducted against several exogenous contaminations, aiming to further access the efficacy and safety of the samples. In conclusion, the quality evaluation system demonstrated here can potentially address the authenticity, quality, and safety of herbal medicines, thus providing novel insight for enhancing their overall quality control.Highlight: We established a comprehensive quality evaluation system for herbal medicine, by combining two genetic-based approaches third-generation sequencing and DGGE (denaturing gradient gel electrophoresis with analytical chemistry approaches to achieve the authentication and quality connotation of the samples.

  5. A Comprehensive Quality Evaluation System for Complex Herbal Medicine Using PacBio Sequencing, PCR-Denaturing Gradient Gel Electrophoresis, and Several Chemical Approaches.

    Science.gov (United States)

    Zheng, Xiasheng; Zhang, Peng; Liao, Baosheng; Li, Jing; Liu, Xingyun; Shi, Yuhua; Cheng, Jinle; Lai, Zhitian; Xu, Jiang; Chen, Shilin

    2017-01-01

    Herbal medicine is a major component of complementary and alternative medicine, contributing significantly to the health of many people and communities. Quality control of herbal medicine is crucial to ensure that it is safe and sound for use. Here, we investigated a comprehensive quality evaluation system for a classic herbal medicine, Danggui Buxue Formula, by applying genetic-based and analytical chemistry approaches to authenticate and evaluate the quality of its samples. For authenticity, we successfully applied two novel technologies, third-generation sequencing and PCR-DGGE (denaturing gradient gel electrophoresis), to analyze the ingredient composition of the tested samples. For quality evaluation, we used high performance liquid chromatography assays to determine the content of chemical markers to help estimate the dosage relationship between its two raw materials, plant roots of Huangqi and Danggui. A series of surveys were then conducted against several exogenous contaminations, aiming to further access the efficacy and safety of the samples. In conclusion, the quality evaluation system demonstrated here can potentially address the authenticity, quality, and safety of herbal medicines, thus providing novel insight for enhancing their overall quality control. Highlight : We established a comprehensive quality evaluation system for herbal medicine, by combining two genetic-based approaches third-generation sequencing and DGGE (denaturing gradient gel electrophoresis) with analytical chemistry approaches to achieve the authentication and quality connotation of the samples.

  6. Increasing crop diversity mitigates weather variations and improves yield stability.

    Science.gov (United States)

    Gaudin, Amélie C M; Tolhurst, Tor N; Ker, Alan P; Janovicek, Ken; Tortora, Cristina; Martin, Ralph C; Deen, William

    2015-01-01

    Cropping sequence diversification provides a systems approach to reduce yield variations and improve resilience to multiple environmental stresses. Yield advantages of more diverse crop rotations and their synergistic effects with reduced tillage are well documented, but few studies have quantified the impact of these management practices on yields and their stability when soil moisture is limiting or in excess. Using yield and weather data obtained from a 31-year long term rotation and tillage trial in Ontario, we tested whether crop rotation diversity is associated with greater yield stability when abnormal weather conditions occur. We used parametric and non-parametric approaches to quantify the impact of rotation diversity (monocrop, 2-crops, 3-crops without or with one or two legume cover crops) and tillage (conventional or reduced tillage) on yield probabilities and the benefits of crop diversity under different soil moisture and temperature scenarios. Although the magnitude of rotation benefits varied with crops, weather patterns and tillage, yield stability significantly increased when corn and soybean were integrated into more diverse rotations. Introducing small grains into short corn-soybean rotation was enough to provide substantial benefits on long-term soybean yields and their stability while the effects on corn were mostly associated with the temporal niche provided by small grains for underseeded red clover or alfalfa. Crop diversification strategies increased the probability of harnessing favorable growing conditions while decreasing the risk of crop failure. In hot and dry years, diversification of corn-soybean rotations and reduced tillage increased yield by 7% and 22% for corn and soybean respectively. Given the additional advantages associated with cropping system diversification, such a strategy provides a more comprehensive approach to lowering yield variability and improving the resilience of cropping systems to multiple environmental

  7. Framework for Infectious Disease Analysis: A comprehensive and integrative multi-modeling approach to disease prediction and management.

    Science.gov (United States)

    Erraguntla, Madhav; Zapletal, Josef; Lawley, Mark

    2017-12-01

    The impact of infectious disease on human populations is a function of many factors including environmental conditions, vector dynamics, transmission mechanics, social and cultural behaviors, and public policy. A comprehensive framework for disease management must fully connect the complete disease lifecycle, including emergence from reservoir populations, zoonotic vector transmission, and impact on human societies. The Framework for Infectious Disease Analysis is a software environment and conceptual architecture for data integration, situational awareness, visualization, prediction, and intervention assessment. Framework for Infectious Disease Analysis automatically collects biosurveillance data using natural language processing, integrates structured and unstructured data from multiple sources, applies advanced machine learning, and uses multi-modeling for analyzing disease dynamics and testing interventions in complex, heterogeneous populations. In the illustrative case studies, natural language processing from social media, news feeds, and websites was used for information extraction, biosurveillance, and situation awareness. Classification machine learning algorithms (support vector machines, random forests, and boosting) were used for disease predictions.

  8. A Comprehensive Design Approach of Power Electronic-Based Distributed Generation Units Focused on Power-Quality Improvement

    DEFF Research Database (Denmark)

    Esparza, Miguel; Segundo, Juan; Nunez, Ciro

    2017-01-01

    -modulated-voltage-source inverters (PWM-VSI). The proposed design method is based on a least square solution using the harmonic domain modeling approach to effectively consider explicitly the harmonic characteristics of the DGUs and their direct and cross-coupling interaction with the grid, loads, and the other DGUs. Extensive...... simulations and analyses against PSCAD are presented in order to show the outstanding performance of the proposed design approach....

  9. Children's exposure to harmful elements in toys and low-cost jewelry: Characterizing risks and developing a comprehensive approach

    Energy Technology Data Exchange (ETDEWEB)

    Guney, Mert; Zagury, Gerald J., E-mail: gerald.zagury@polymtl.ca

    2014-04-01

    Highlights: • Risk for children up to 3 years-old was characterized considering oral exposure. • Saliva mobilization, ingestion of parts and of scraped-off material were considered. • Ingestion of parts caused hazard index (HI) values >>for Cd, Ni, and Pb exposure. • HI were lower (but > for saliva mobilization and <1 for scraped material ingestion. • Comprehensive approach aims to deal with drawbacks of current toy safety approaches. - Abstract: Contamination problem in jewelry and toys and children's exposure possibility have been previously demonstrated. For this study, risk from oral exposure has been characterized for highly contaminated metallic toys and jewelry ((MJ), n = 16) considering three scenarios. Total and bioaccessible concentrations of Cd, Cu, Ni, and Pb were high in selected MJ. First scenario (ingestion of parts or pieces) caused unacceptable risk for eight items for Cd, Ni, and/or Pb (hazard index (HI) > 1, up to 75, 5.8, and 43, respectively). HI for ingestion of scraped-off material scenario was always <1. Finally, saliva mobilization scenario caused HI > 1 in three samples (two for Cd, one for Ni). Risk characterization identified different potentially hazardous items compared to United States, Canadian, and European Union approaches. A comprehensive approach was also developed to deal with complexity and drawbacks caused by various toy/jewelry definitions, test methods, exposure scenarios, and elements considered in different regulatory approaches. It includes bioaccessible limits for eight priority elements (As, Cd, Cr, Cu, Hg, Ni, Pb, and Sb). Research is recommended on metals bioaccessibility determination in toys/jewelry, in vitro bioaccessibility test development, estimation of material ingestion rates and frequency, presence of hexavalent Cr and organic Sn, and assessment of prolonged exposure to MJ.

  10. Harnessing Diversity in Wheat to Enhance Grain Yield, Climate Resilience, Disease and Insect Pest Resistance and Nutrition Through Conventional and Modern Breeding Approaches

    Science.gov (United States)

    Mondal, Suchismita; Rutkoski, Jessica E.; Velu, Govindan; Singh, Pawan K.; Crespo-Herrera, Leonardo A.; Guzmán, Carlos; Bhavani, Sridhar; Lan, Caixia; He, Xinyao; Singh, Ravi P.

    2016-01-01

    Current trends in population growth and consumption patterns continue to increase the demand for wheat, a key cereal for global food security. Further, multiple abiotic challenges due to climate change and evolving pathogen and pests pose a major concern for increasing wheat production globally. Triticeae species comprising of primary, secondary, and tertiary gene pools represent a rich source of genetic diversity in wheat. The conventional breeding strategies of direct hybridization, backcrossing and selection have successfully introgressed a number of desirable traits associated with grain yield, adaptation to abiotic stresses, disease resistance, and bio-fortification of wheat varieties. However, it is time consuming to incorporate genes conferring tolerance/resistance to multiple stresses in a single wheat variety by conventional approaches due to limitations in screening methods and the lower probabilities of combining desirable alleles. Efforts on developing innovative breeding strategies, novel tools and utilizing genetic diversity for new genes/alleles are essential to improve productivity, reduce vulnerability to diseases and pests and enhance nutritional quality. New technologies of high-throughput phenotyping, genome sequencing and genomic selection are promising approaches to maximize progeny screening and selection to accelerate the genetic gains in breeding more productive varieties. Use of cisgenic techniques to transfer beneficial alleles and their combinations within related species also offer great promise especially to achieve durable rust resistance. PMID:27458472

  11. Material flow analysis of NdFeB magnets for Denmark: a comprehensive waste flow sampling and analysis approach.

    Science.gov (United States)

    Habib, Komal; Schibye, Peter Klausen; Vestbø, Andreas Peter; Dall, Ole; Wenzel, Henrik

    2014-10-21

    Neodymium-iron-boron (NdFeB) magnets have become highly desirable for modern hi-tech applications. These magnets, in general, contain two key rare earth elements (REEs), i.e., neodymium (Nd) and dysprosium (Dy), which are responsible for the very high strength of these magnets, allowing for considerable size and weight reduction in modern applications. This study aims to explore the current and future potential of a secondary supply of neodymium and dysprosium from recycling of NdFeB magnets. For this purpose, material flow analysis (MFA) has been carried out to perform the detailed mapping of stocks and flows of NdFeB magnets in Denmark. A novel element of this study is the value added to the traditionally practiced MFAs at national and/or global levels by complementing them with a comprehensive sampling and elemental analysis of NdFeB magnets, taken out from a sample of 157 different products representing 18 various product types. The results show that the current amount of neodymium and dysprosium in NdFeB magnets present in the Danish waste stream is only 3 and 0.2 Mg, respectively. However, this number is estimated to increase to 175 Mg of neodymium and 11.4 Mg of dysprosium by 2035. Nevertheless, efficient recovery of these elements from a very diverse electronic waste stream remains a logistic and economic challenge.

  12. Transforming Bloom's Taxonomy into Classroom Practice: A Practical yet Comprehensive Approach to Promote Critical Reading and Student Participation

    Science.gov (United States)

    Mulcare, Daniel M.; Shwedel, Allan

    2017-01-01

    This article presents the Critical Reading Topics approach, a pedagogical method employed to promote deep thinking in a variety of politics courses. Derived from principles articulated in active learning, critical thinking, backward design, and flipped classroom literature, this method utilizes Bloom's Taxonomy as the scaffolding for students to…

  13. WHO guidance grounded in a comprehensive approach to sexual and reproductive health and human rights: topical pre-exposure prophylaxis.

    Science.gov (United States)

    Lusti-Narasimhan, Manjula; Khosla, Rajat; Baggaley, Rachel; Temmerman, Marleen; McGrory, Elizabeth; Farley, Tim

    2014-01-01

    Two new microbicide products based on topical (vaginal) application of antiretroviral drugs - 1% tenofovir gel and the dapivirine ring - are currently in late-stage clinical testing, and results on their safety and effectiveness are expected to become available in early 2015. WHO guidelines on the use of topical pre-exposure prophylaxis (topical PrEP) are important in order to ensure that these new prevention products are optimally used. Given that these new topical PrEP products are designed to be woman initiated and will likely be delivered in reproductive health settings, it is important to ensure that the guidance be framed in the context of comprehensive sexual and reproductive health and human rights. In addition to the safety and effectiveness data resulting from clinical trials, and the regulatory approval required for new products, the WHO normative guidelines on the use of topical PrEP will be essential for rapid roll-out in countries. Human rights standards and principles provide a framework for the provision of woman-initiated HIV prevention products. These include addressing issues related to the gender inequities which are linked to the provision of HIV-prevention, treatment and care for young girls and women. Effective programming for women and girls must therefore be based on understanding the local, social and community contexts of the AIDS epidemic in the country, and adapting HIV strategies and programmes accordingly. Such a framework therefore is needed not only to ensure optimal uptake of these new products by women and girls but also to address sociocultural barriers to women's and girls' access to these products.

  14. Methicillin-Resistant Staphylococcus aureus Infections: A Comprehensive Review and a Plastic Surgeon's Approach to the Occult Sites.

    Science.gov (United States)

    Hunter, Cedric; Rosenfield, Lorne; Silverstein, Elena; Petrou-Zeniou, Panayiota

    2016-08-01

    Up to 20 percent of the general population is persistently colonized with Staphylococcus aureus, and 1 to 3 percent of the population is colonized with community-acquired methicillin-resistant S. aureus. Currently, the knowledge of methicillin-resistant Staphylococcus aureus carriage sites other than the nose, and their effect on surgical site infections in cosmetic surgery, is lacking. A comprehensive literature review using the PubMed database to analyze prevalence, anatomical carrier sites, current screening and decontamination protocols and guidelines, and methicillin-resistant S. aureus in cosmetic surgery was performed. The senior author's (L.R.) methicillin-resistant S. aureus infection experience and prevention protocols were also reviewed. Nasal swabs detect only 50.5 percent of methicillin-resistant S. aureus colonization, and broad screening has noted the presence of methicillin-resistant S. aureus in the ear canal and umbilicus. Decolonization protocols within the orthopedic and cardiothoracic surgery literature have reduced rates of methicillin-resistant S. aureus surgical-site infections. There are no decolonization guidelines for plastic surgeons. Since instituting their decolonization protocol, the authors have had no cases of methicillin-resistant S. aureus infection in nearly 1000 cosmetic surgery procedures. There are very limited, if any, Level I or II data regarding methicillin-resistant S. aureus screening and decolonization. As the sequelae of a surgical-site infection can be disastrous, expert opinions recommend that plastic surgeons vigorously address methicillin-resistant S. aureus colonization and infection. The authors have developed and recommend a simple decolonization protocol that includes treatment of the umbilicus, ear canal, and nares to limit surgical-site infection and improve surgical outcomes.

  15. Integrated bioleaching of copper metal from waste printed circuit board-a comprehensive review of approaches and challenges.

    Science.gov (United States)

    Awasthi, Abhishek Kumar; Zeng, Xianlai; Li, Jinhui

    2016-11-01

    Waste electrical and electronic equipment (e-waste) is the most rapidly growing waste stream in the world, and the majority of the residues are openly disposed of in developing countries. Waste printed circuit boards (WPCBs) make up the major portion of e-waste, and their informal recycling can cause environmental pollution and health risks. Furthermore, the conventional disposal and recycling techniques-mechanical treatments used to recover valuable metals, including copper-are not sustainable in the long term. Chemical leaching is rapid and efficient but causes secondary pollution. Bioleaching is a promising approach, eco-friendly and economically feasible, but it is slower process. This review considers the recycling potential of microbes and suggests an integrated bioleaching approach for Cu extraction and recovery from WPCBs. The proposed recycling system should be more effective, efficient and both technically and economically feasible.

  16. China’s Comprehensive Approach: Refining the U.S. Targeting Process to Inform U.S. Strategy

    Science.gov (United States)

    2018-04-20

    engagement of key PRC leaders with other world leaders and multinational organizations. The bottom-up approach relies upon the vast Chinese population...internal affairs, equality and mutual benefit for all parties, and a peaceful coexistence.33 Much like Chinese leaders that preceded him, Xi Jinping’s... autocratic structure. For example, Xi Jinping’s ability to control the buildup of China’s military capabilities and economic expansions designed to benefit

  17. Comprehensive Approach to Verification and Validation of CFD Simulations Applied to Backward Facing Step-Application of CFD Uncertainty Analysis

    Science.gov (United States)

    Groves, Curtis E.; LLie, Marcel; Shallhorn, Paul A.

    2012-01-01

    There are inherent uncertainties and errors associated with using Computational Fluid Dynamics (CFD) to predict the flow field and there is no standard method for evaluating uncertainty in the CFD community. This paper describes an approach to -validate the . uncertainty in using CFD. The method will use the state of the art uncertainty analysis applying different turbulence niodels and draw conclusions on which models provide the least uncertainty and which models most accurately predict the flow of a backward facing step.

  18. Interacting Agricultural Pests and Their Effect on Crop Yield: Application of a Bayesian Decision Theory Approach to the Joint Management of Bromus tectorum and Cephus cinctus

    Science.gov (United States)

    Keren, Ilai N.; Menalled, Fabian D.; Weaver, David K.; Robison-Cox, James F.

    2015-01-01

    Worldwide, the landscape homogeneity of extensive monocultures that characterizes conventional agriculture has resulted in the development of specialized and interacting multitrophic pest complexes. While integrated pest management emphasizes the need to consider the ecological context where multiple species coexist, management recommendations are often based on single-species tactics. This approach may not provide satisfactory solutions when confronted with the complex interactions occurring between organisms at the same or different trophic levels. Replacement of the single-species management model with more sophisticated, multi-species programs requires an understanding of the direct and indirect interactions occurring between the crop and all categories of pests. We evaluated a modeling framework to make multi-pest management decisions taking into account direct and indirect interactions among species belonging to different trophic levels. We adopted a Bayesian decision theory approach in combination with path analysis to evaluate interactions between Bromus tectorum (downy brome, cheatgrass) and Cephus cinctus (wheat stem sawfly) in wheat (Triticum aestivum) systems. We assessed their joint responses to weed management tactics, seeding rates, and cultivar tolerance to insect stem boring or competition. Our results indicated that C. cinctus oviposition behavior varied as a function of B. tectorum pressure. Crop responses were more readily explained by the joint effects of management tactics on both categories of pests and their interactions than just by the direct impact of any particular management scheme on yield. In accordance, a C. cinctus tolerant variety should be planted at a low seeding rate under high insect pressure. However as B. tectorum levels increase, the C. cinctus tolerant variety should be replaced by a competitive and drought tolerant cultivar at high seeding rates despite C. cinctus infestation. This study exemplifies the necessity of

  19. Interacting agricultural pests and their effect on crop yield: application of a Bayesian decision theory approach to the joint management of Bromus tectorum and Cephus cinctus.

    Science.gov (United States)

    Keren, Ilai N; Menalled, Fabian D; Weaver, David K; Robison-Cox, James F

    2015-01-01

    Worldwide, the landscape homogeneity of extensive monocultures that characterizes conventional agriculture has resulted in the development of specialized and interacting multitrophic pest complexes. While integrated pest management emphasizes the need to consider the ecological context where multiple species coexist, management recommendations are often based on single-species tactics. This approach may not provide satisfactory solutions when confronted with the complex interactions occurring between organisms at the same or different trophic levels. Replacement of the single-species management model with more sophisticated, multi-species programs requires an understanding of the direct and indirect interactions occurring between the crop and all categories of pests. We evaluated a modeling framework to make multi-pest management decisions taking into account direct and indirect interactions among species belonging to different trophic levels. We adopted a Bayesian decision theory approach in combination with path analysis to evaluate interactions between Bromus tectorum (downy brome, cheatgrass) and Cephus cinctus (wheat stem sawfly) in wheat (Triticum aestivum) systems. We assessed their joint responses to weed management tactics, seeding rates, and cultivar tolerance to insect stem boring or competition. Our results indicated that C. cinctus oviposition behavior varied as a function of B. tectorum pressure. Crop responses were more readily explained by the joint effects of management tactics on both categories of pests and their interactions than just by the direct impact of any particular management scheme on yield. In accordance, a C. cinctus tolerant variety should be planted at a low seeding rate under high insect pressure. However as B. tectorum levels increase, the C. cinctus tolerant variety should be replaced by a competitive and drought tolerant cultivar at high seeding rates despite C. cinctus infestation. This study exemplifies the necessity of

  20. Interacting agricultural pests and their effect on crop yield: application of a Bayesian decision theory approach to the joint management of Bromus tectorum and Cephus cinctus.

    Directory of Open Access Journals (Sweden)

    Ilai N Keren

    Full Text Available Worldwide, the landscape homogeneity of extensive monocultures that characterizes conventional agriculture has resulted in the development of specialized and interacting multitrophic pest complexes. While integrated pest management emphasizes the need to consider the ecological context where multiple species coexist, management recommendations are often based on single-species tactics. This approach may not provide satisfactory solutions when confronted with the complex interactions occurring between organisms at the same or different trophic levels. Replacement of the single-species management model with more sophisticated, multi-species programs requires an understanding of the direct and indirect interactions occurring between the crop and all categories of pests. We evaluated a modeling framework to make multi-pest management decisions taking into account direct and indirect interactions among species belonging to different trophic levels. We adopted a Bayesian decision theory approach in combination with path analysis to evaluate interactions between Bromus tectorum (downy brome, cheatgrass and Cephus cinctus (wheat stem sawfly in wheat (Triticum aestivum systems. We assessed their joint responses to weed management tactics, seeding rates, and cultivar tolerance to insect stem boring or competition. Our results indicated that C. cinctus oviposition behavior varied as a function of B. tectorum pressure. Crop responses were more readily explained by the joint effects of management tactics on both categories of pests and their interactions than just by the direct impact of any particular management scheme on yield. In accordance, a C. cinctus tolerant variety should be planted at a low seeding rate under high insect pressure. However as B. tectorum levels increase, the C. cinctus tolerant variety should be replaced by a competitive and drought tolerant cultivar at high seeding rates despite C. cinctus infestation. This study exemplifies the

  1. A Comprehensive Approach Towards Optimizing the Xenon Plasma Focused Ion Beam Instrument for Semiconductor Failure Analysis Applications.

    Science.gov (United States)

    Subramaniam, Srinivas; Huening, Jennifer; Richards, John; Johnson, Kevin

    2017-08-01

    The xenon plasma focused ion beam instrument (PFIB), holds significant promise in expanding the applications of focused ion beams in new technology thrust areas. In this paper, we have explored the operational characteristics of a Tescan FERA3 XMH PFIB instrument with the aim of meeting current and future challenges in the semiconductor industry. A two part approach, with the first part aimed at optimizing the ion column and the second optimizing specimen preparation, has been undertaken. Detailed studies characterizing the ion column, optimizing for high-current/high mill rate activities, have been described to support a better understanding of the PFIB. In addition, a novel single-crystal sacrificial mask method has been developed and implemented for use in the PFIB. Using this combined approach, we have achieved high-quality images with minimal artifacts, while retaining the shorter throughput times of the PFIB. Although the work presented in this paper has been performed on a specific instrument, the authors hope that these studies will provide general insight to direct further improvement of PFIB design and applications.

  2. A New Perspective in the Middle East: A Comprehensive Approach To The Us-Iran Relations in the Region

    Directory of Open Access Journals (Sweden)

    Mehdi Shokri

    2016-12-01

    Full Text Available This paper discusses the significance of the cooperation between the United States and Iran for the Middle East region. It will be argued that despite the political and ideological conflicts between the U.S. and Iran, reaching a “point by point” agreement would best help to resolve Middle East predicaments, especially the Islamic terrorism. To achieve this, the following pages examine the historical background of issues such as terrorism in the Middle East. This paper also focuses on two main paths to support the better U.S.-Iran cooperation, if not talking about relations at all. First, the theory of “point by point” approach helps both countries to tackle tough agendas and overcome the predicaments in the Middle East. Second, to reach the desired cooperation between these two countries, both the U.S. and Iran need to overcome their own internal constraints as well as the external constrains imposed by other countries. This paper takes an historical and theoretical approach to reveal the two countries’ common interests in the Middle East. The general thesis argues that the Middle East’s security requires the United States and Iran to develop a diplomatic and military cooperation.

  3. Current approach to the diagnosis of IgG4-related disease - Combination of comprehensive diagnostic and organ-specific criteria.

    Science.gov (United States)

    Umehara, Hisanori; Okazaki, Kazuichi; Nakamura, Takuji; Satoh-Nakamura, Tomomi; Nakajima, Akio; Kawano, Mitsuhiro; Mimori, Tsuneyo; Chiba, Tsutomu

    2017-05-01

    IgG4-related disease (IgG4-RD) is a fascinating clinical entity proposed by Japanese investigators, and includes a wide variety of diseases, formerly diagnosed as Mikulicz's disease (MD), autoimmune pancreatitis (AIP), interstitial nephritis, prostatitis, retroperitoneal fibrosis, etc. Although all clinicians in every field of medicine may encounter this new disease, a unifying diagnostic criterion has not been established. In 2011, the Japanese IgG4 team, organized by the Ministry of Health, Labor and Welfare (MHLW) of Japan, published comprehensive diagnostic criteria for IgG4-RD. Several problems with these criteria have arisen in clinical practice, however, including the difficulty obtaining biopsy samples from some patients, and the sensitivity and the specificity of techniques used to measure serum IgG4 concentrations. Although serum IgG4 concentration is an important clinical marker for IgG4-RD, its diagnostic utility in differentiating IgG4-RD from other diseases, called IgG4-RD mimickers, remains unclear. This review describes the current optimal approach for the diagnosis of IgG4-RD, based on both comprehensive and organ-specific diagnostic criteria, in patients with diseases such as IgG4-related pancreatitis (AIP), sclerosing cholangitis, and renal, lung and orbital diseases.

  4. Comprehensive spectral and instrumental approaches for the easy monitoring of features and purity of different carbon nanostructures for nanocomposite applications

    International Nuclear Information System (INIS)

    Boccaleri, Enrico; Arrais, Aldo; Frache, Alberto; Gianelli, Walter; Fino, Paolo; Camino, Giovanni

    2006-01-01

    A wide series of carbon nanostructures (ranging from fullerenes, through carbon nanotubes, up to carbon nanofibers) promise to change several fields in material science, but a real industrial implementation depends on their availability at reasonable prices with affordable and reproducible degrees of purity. In this study we propose simple instrumental approaches to efficiently characterize different commercial samples, particularly for qualitative evaluation of impurities, the discrimination of their respective spectral features and, when possible, for quantitative determination. We critically discuss information that researchers in the field of nanocomposite technology can achieve in this aim by spectral techniques such as Raman and FT-IR spectroscopy, thermo-gravimetrical analysis, mass spectrometry-hyphenated thermogravimetry, X-ray diffraction and energy dispersive spectroscopy. All these can be helpful, in applied research on material science, for a fast reliable monitoring of the actual purity of carbon products in both commercial and laboratory-produced samples as well as in composite materials

  5. Comprehensive suppression of all apoptosis-induced proliferation pathways as a proposed approach to colorectal cancer prevention and therapy.

    Directory of Open Access Journals (Sweden)

    Michael Bordonaro

    Full Text Available Mutations in the WNT/beta-catenin pathway are present in the majority of all sporadic colorectal cancers (CRCs, and histone deacetylase inhibitors induce apoptosis in CRC cells with such mutations. This apoptosis is counteracted by (1 the signaling heterogeneity of CRC cell populations, and (2 the survival pathways induced by mitogens secreted from apoptotic cells. The phenomena of signaling heterogeneity and apoptosis-induced survival constitute the immediate mechanisms of resistance to histone deacetylase inhibitors, and probably other chemotherapeutic agents. We explored the strategy of augmenting CRC cell death by inhibiting all survival pathways induced by the pro-apoptotic agent LBH589, a histone deacetylase inhibitor: AKT, JAK/STAT, and ERK signaling. The apoptosis-enhancing ability of a cocktail of synthetic inhibitors of proliferation was compared to the effects of the natural product propolis. We utilized colorectal adenoma, drug-sensitive and drug-resistant colorectal carcinoma cells to evaluate the apoptotic potential of the combination treatments. The results suggest that an effective approach to CRC combination therapy is to combine apoptosis-inducing drugs (e.g., histone deacetylase inhibitors, such as LBH589 with agents that suppress all compensatory survival pathways induced during apoptosis (such as the cocktail of inhibitors of apoptosis-associated proliferation. The same paradigm can be applied to a CRC prevention approach, as the apoptotic effect of butyrate, a diet-derived histone deacetylase inhibitor, is augmented by other dietary agents that modulate survival pathways (e.g., propolis and coffee extract. Thus, dietary supplements composed by fermentable fiber, propolis, and coffee extract may effectively counteract neoplastic growth in the colon.

  6. A Comprehensive Approach to Motorcycle-Related Head Injury Prevention: Experiences from the Field in Vietnam, Cambodia, and Uganda.

    Science.gov (United States)

    Craft, Greig; Van Bui, Truong; Sidik, Mirjam; Moore, Danielle; Ederer, David J; Parker, Erin M; Ballesteros, Michael F; Sleet, David A

    2017-11-30

    Motorcyclists account for 23% of global road traffic deaths and over half of fatalities in countries where motorcycles are the dominant means of transport. Wearing a helmet can reduce the risk of head injury by as much as 69% and death by 42%; however, both child and adult helmet use are low in many countries where motorcycles are a primary mode of transportation. In response to the need to increase helmet use by all drivers and their passengers, the Global Helmet Vaccine Initiative (GHVI) was established to increase helmet use in three countries where a substantial portion of road users are motorcyclists and where helmet use is low. The GHVI approach includes five strategies to increase helmet use: targeted programs, helmet access, public awareness, institutional policies, and monitoring and evaluation. The application of GHVI to Vietnam, Cambodia, and Uganda resulted in four key lessons learned. First, motorcyclists are more likely to wear helmets when helmet use is mandated and enforced. Second, programs targeted to at-risk motorcyclists, such as child passengers, combined with improved awareness among the broader population, can result in greater public support needed to encourage action by decision-makers. Third, for broad population-level change, using multiple strategies in tandem can be more effective than using a single strategy alone. Lastly, the successful expansion of GHVI into Cambodia and Uganda has been hindered by the lack of helmet accessibility and affordability, a core component contributing to its success in Vietnam. This paper will review the development of the GHVI five-pillar approach in Vietnam, subsequent efforts to implement the model in Cambodia and Uganda, and lessons learned from these applications to protect motorcycle drivers and their adult and child passengers from injury.

  7. Comprehensive approach to energy and environment in the Eco Care Program for design, engineering and operation of Siemens Industry Solutions

    Energy Technology Data Exchange (ETDEWEB)

    Wegener, D. (Siemens AG, Erlangen (Germany)); Finkbeiner, M. (Technische Univ. Berlin (TUB), Systemumwelttechnik (SUT), Berlin (Germany)); Geiger, D. (Siemens AG, Munich (Germany)); Olsen, S.I. (Danish Technical Univ. (DTU), Management Engineering, Lyngby (Denmark)); Walachowicz, F. (Siemens AG, Berlin (Germany))

    2009-09-15

    This paper intends to describe the outline of the Eco Care Program (ECP) at the Siemens-Division Industry Solutions and its implementation. ECP aims to embrace and to coordinate main activities within the product lifecycle management (PLM) process considering both economic targets in terms of overall lifecycle costs as well as energy efficiency and other important environmental issues in the innovation management for industrial solutions. ECP consists of adapted methods for assessing the environmental and financial impacts of industrial solutions (plants, processes, single technologies or even services) and tools which helps to derive reliable assessment results. Life Cycle Assessment (LCA) is a suitable method for assessing environmental impacts of products and solutions over their entire lifecycle focusing on those lifecycle phases which may contribute significantly to environmental burdens or benefits. To meet these requirements the main challenge is to simplify the assessment methodology as far as reliability and accuracy of results is preserved. To present results in both dimensions of economical performance and environmental impact the paper introduces the concept of the 'eco care matrix' (ECM). Environmental sound industrial solutions have advantages in both 'eco' dimensions (eco-nomical + eco-logical). The analytical approach presented is further on implemented in two complementary and independent industrial application fields: in order to exemplify usability of the approach in quite complex process technology different hot metal producing technologies (blast furnace route vs. smelting reduction routes COREX / FINEX). The second pilot application is targeted on the assessment of infrastructure solutions especially focusing on the comparison of environmental and financial effects of different technologies and payment schemes of electronic city tolling systems for London and Copenhagen. Experienced results derived from these two pilot

  8. Novel comprehensive multidimensional liquid chromatography approach for elucidation of the microbosphere of shikimate-producing Escherichia coli SP1.1/pKD15.071 strain.

    Science.gov (United States)

    Cacciola, Francesco; Mangraviti, Domenica; Rigano, Francesca; Donato, Paola; Dugo, Paola; Mondello, Luigi; Cortes, Hernan J

    2018-06-01

    Shikimic acid is a intermediate of aromatic amino acid biosynthesis and the preferred starting material for production of the most commonly prescribed anti-influenza drug, Tamiflu. Its six-membered carbocyclic ring is adorned with several chiral centers and various functionalities, making shikimic acid a valuable chiral synthon. When microbially-produced, in addition to shikimic acid, numerous other metabolites are exported out of the cytoplasm and accumulate in the culture medium. This extracellular matrix of metabolites is referred to as the microbosphere. Due to the high sample complexity, in this study, the microbosphere of shikimate-producing Escherichia coli SP1.1/pKD15.071 was analyzed by liquid chromatography and comprehensive two-dimensional liquid chromatography coupled to photodiode array and mass spectrometry detection. GC analysis of the trimethylsilyl derivatives was also carried out in order to support the elucidation of the selected metabolites in the microbosphere. The elucidation of the metabolic fraction of this bacterial strain might be of valid aid for improving, through genetic changes, the concentration and yield of shikimic acid synthesized from glucose. Graphical abstract.

  9. A comprehensive approach in high-grade glioma management: position statement from the Neuro-Oncology Scientific Club (NOSC), Shiraz, Iran.

    Science.gov (United States)

    Ansari, Mansour; Mosalaei, Ahmad; Ahmadloo, Niloufar; Rasekhi, Alireza; Geramizadeh, Bita; Razmkon, Ali; Anvari, Kazem; Afarid, Mohammad; Dadras, Ali; Nafarieh, Leila; Mohammadianpanah, Mohammad; Nasrolahi, Hamid; Hamedi, Seyed Hasan; Omidvari, Shapour; Nami, Mohammad

    2017-01-01

    Establishing a robust teamwork model in the practice of neuro-oncology requires continued interdisciplinary efforts. The Neuro-Oncology Scientific Club (NOSC) initiative is an interdisciplinary clinical forum promoting the comprehensive approach across involved disciplines in the management of central nervous system (CNS) malignancies. With its provincial founding panels and national steering board, NOSC has been operational in Iran since 2011. This initiative has pursued its mission through interval strategic meetings, tumor boards, case discussions as well as publishing neuro-oncology updates, case study periodicals, and newsletters. A provincial meeting of NOSC in Shiraz put together insights from international practice guidelines, emerging evidence, and expert opinions to draw a position statement on high-grade glioma management in adults. The present report summarizes key highlights from the above clinical forum.

  10. A comprehensive approach in high-grade glioma management: position statement from the Neuro-Oncology Scientific Club (NOSC, Shiraz, Iran

    Directory of Open Access Journals (Sweden)

    Ansari, Mansour

    2017-02-01

    Full Text Available Establishing a robust teamwork model in the practice of neuro-oncology requires continued interdisciplinary efforts. The Neuro-Oncology Scientific Club (NOSC initiative is an interdisciplinary clinical forum promoting the comprehensive approach across involved disciplines in the management of central nervous system (CNS malignancies. With its provincial founding panels and national steering board, NOSC has been operational in Iran since 2011. This initiative has pursued its mission through interval strategic meetings, tumor boards, case discussions as well as publishing neuro-oncology updates, case study periodicals, and newsletters. A provincial meeting of NOSC in Shiraz put together insights from international practice guidelines, emerging evidence, and expert opinions to draw a position statement on high-grade glioma management in adults. The present report summarizes key highlights from the above clinical forum.

  11. Enhancing the effectiveness of biological control programs of invasive species through a more comprehensive pest management approach.

    Science.gov (United States)

    DiTomaso, Joseph M; Van Steenwyk, Robert A; Nowierski, Robert M; Vollmer, Jennifer L; Lane, Eric; Chilton, Earl; Burch, Patrick L; Cowan, Phil E; Zimmerman, Kenneth; Dionigi, Christopher P

    2017-01-01

    Invasive species are one of the greatest economic and ecological threats to agriculture and natural areas in the US and the world. Among the available management tools, biological control provides one of the most economical and long-term effective strategies for managing widespread and damaging invasive species populations of nearly all taxa. However, integrating biological control programs in a more complete integrated pest management approach that utilizes increased information and communication, post-release monitoring, adaptive management practices, long-term stewardship strategies, and new and innovative ecological and genetic technologies can greatly improve the effectiveness of biological control. In addition, expanding partnerships among relevant national, regional, and local agencies, as well as academic scientists and land managers, offers far greater opportunities for long-term success in the suppression of established invasive species. In this paper we direct our recommendations to federal agencies that oversee, fund, conduct research, and develop classical biological control programs for invasive species. By incorporating these recommendations into adaptive management strategies, private and public land managers will have far greater opportunities for long-term success in suppression of established invasive species. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

  12. Training opioid addiction treatment providers to adopt contingency management: A prospective pilot trial of a comprehensive implementation science approach.

    Science.gov (United States)

    Becker, Sara J; Squires, Daniel D; Strong, David R; Barnett, Nancy P; Monti, Peter M; Petry, Nancy M

    2016-01-01

    Few prospective studies have evaluated theory-driven approaches to the implementation of evidence-based opioid treatment. This study compared the effectiveness of an implementation model (Science to Service Laboratory; SSL) to training as usual (TAU) in promoting the adoption of contingency management across a multisite opioid addiction treatment program. We also examined whether the SSL affected putative mediators of contingency management adoption (perceived innovation characteristics and organizational readiness to change). Sixty treatment providers (39 SSL, 21 TAU) from 15 geographically diverse satellite clinics (7 SSL, 8 TAU) participated in the 12-month study. Both conditions received didactic contingency management training and those in the predetermined experimental region received 9 months of SSL-enhanced training. Contingency management adoption was monitored biweekly, whereas putative mediators were measured at baseline, 3 months, and 12 months. Relative to providers in the TAU region, treatment providers in the SSL region had comparable likelihood of contingency management adoption in the first 20 weeks of the study, and then significantly higher likelihood of adoption (odds ratios = 2.4-13.5) for the remainder of the study. SSL providers also reported higher levels of one perceived innovation characteristic (Observability) and one aspect of organizational readiness to change (Adequacy of Training Resources), although there was no evidence that the SSL affected these putative mediators over time. Results of this study indicate that a fully powered randomized trial of the SSL is warranted. Considerations for a future evaluation are discussed.

  13. Implementation of Safe-by-Design for Nanomaterial Development and Safe Innovation: Why We Need a Comprehensive Approach.

    Science.gov (United States)

    Kraegeloh, Annette; Suarez-Merino, Blanca; Sluijters, Teun; Micheletti, Christian

    2018-04-14

    Manufactured nanomaterials (MNMs) are regarded as key components of innovations in various fields with high potential impact (e.g., energy generation and storage, electronics, photonics, diagnostics, theranostics, or drug delivery agents). Widespread use of MNMs raises concerns about their safety for humans and the environment, possibly limiting the impact of the nanotechnology-based innovation. The development of safe MNMs and nanoproducts has to result in a safe as well as functional material or product. Its safe use, and disposal at the end of its life cycle must be taken into account too. However, not all MNMs are similarly useful for all applications, some might bear a higher hazard potential than others, and use scenarios could lead to different exposure probabilities. To improve both safety and efficacy of nanotechnology, we think that a new proactive approach is necessary, based on pre-regulatory safety assessment and dialogue between stakeholders. On the basis of the work carried out in different European Union (EU) initiatives, developing and integrating MNMs Safe-by-Design and Trusted Environments (NANoREG, ProSafe, and NanoReg2), we present our point of view here. This concept, when fully developed, will allow for cost effective industrial innovation, and an exchange of key information between regulators and innovators. Regulators are thus informed about incoming innovations in good time, supporting a proactive regulatory action. The final goal is to contribute to the nanotechnology governance, having faster, cheaper, effective, and safer nano-products on the market.

  14. Civilian Joint Task Force’ (CJTF – A Community Security Option: A Comprehensive and Proactive Approach of Reducing Terrorism

    Directory of Open Access Journals (Sweden)

    Oluwaseun Bamidele

    2016-06-01

    Full Text Available Since the Boko Haram uprising in 2009, the Nigerian government has employed various strategies as counter-terrorism measures to stem the atrocities of the group. These strategies include amnesty negotiations, implementation of emergency law in the northeast, increase in security spending to the deployment of military force. In the midst of these security measures, the civilian Joint Task Force (JTF emerged, first as a community effort, and later as a joint effort with the security forces to help fight Boko Haram. The civilian JTF has helped recover towns and villages from Boko Haram, rescued women in the northeast and helped identify Boko Haram members shielded by some local people. Although doubts have been expressed in some quatres that the civilian JTF could transform into ethnic militias, the Boko Haram security threat neutralized by the group indicates an untapped security potential in Nigerian communities. However, one approach that has yet to be pursued is community security option. Community security option is a model built around proactive citizen-driven communal response. This article explains the role of civilian JTF and how civilian JTF can be used to investigate terrorism in Nigeria. This article will contribute to the discourse on the imperative of African-inspired mechanisms to solving African security problems.

  15. Can we use modelling methodologies to assess airborne benzo[a]pyrene from biomonitors? A comprehensive evaluation approach

    Science.gov (United States)

    Ratola, N.; Jiménez-Guerrero, P.

    2015-09-01

    Biomonitoring data available on levels of atmospheric polycyclic aromatic hydrocarbons (PAHs) in pine needles from the Iberian Peninsula was used to estimate air concentrations of benzo[a]pyrene (BaP) and, at the same time, fuelled the comparison with chemistry transport model representations. Simulations with the modelling system WRF + CHIMERE were validated against data from the European Monitoring and Evaluation Programme (EMEP) air sampling network and using modelled atmospheric concentrations as a consistent reference in order to compare the performance of vegetation-to-air estimating methods. A spatial and temporal resolution of 9 km and 1 h was implemented. The field-based database relied on a pine needles sampling scheme comprising 33 sites in Portugal and 37 sites in Spain complemented with the BaP measurements available from the EMEP sites. The ability of pine needles to act as biomonitoring markers for the atmospheric concentrations of BaP was estimated converting the levels obtained in pine needles into air concentrations by six different approaches, one of them presenting realistic concentrations when compared to the modelled atmospheric values. The justification for this study is the gaps still existing in the knowledge of the life cycles of semi-volatile organic compounds (SVOCs), particularly the partition processes between air and vegetation. The strategy followed in this work allows the definition of the transport patterns (e.g. dispersion) established by the model for atmospheric concentrations and the estimated values in vegetation.

  16. Translational ethics: an analytical framework of translational movements between theory and practice and a sketch of a comprehensive approach.

    Science.gov (United States)

    Bærøe, Kristine

    2014-09-30

    , carefully designed, overall approaches combining justified, self-reflexive philosophical and practical efforts according to the suggested distinctions could be expected to realise - or at least improve a facilitation of - translation of ethics across the theory-practice gap.

  17. Take Heart America: A comprehensive, community-wide, systems-based approach to the treatment of cardiac arrest.

    Science.gov (United States)

    Lick, Charles J; Aufderheide, Tom P; Niskanen, Robert A; Steinkamp, Janet E; Davis, Scott P; Nygaard, Susan D; Bemenderfer, Kim K; Gonzales, Louis; Kalla, Jeffrey A; Wald, Sarah K; Gillquist, Debbie L; Sayre, Michael R; Osaki Holm, Susie Y; Oski Holm, Susie Y; Oakes, Dana A; Provo, Terry A; Racht, Ed M; Olsen, John D; Yannopoulos, Demetris; Lurie, Keith G

    2011-01-01

    concept was financially feasible, despite the costs associated with high-quality postresuscitation care. The Take Heart America program doubled cardiac arrest survival when compared with historical controls. Study of the feasibility of generalizing this approach to larger cities, states, and regions is underway.

  18. Estimating Corporate Yield Curves

    OpenAIRE

    Antionio Diaz; Frank Skinner

    2001-01-01

    This paper represents the first study of retail deposit spreads of UK financial institutions using stochastic interest rate modelling and the market comparable approach. By replicating quoted fixed deposit rates using the Black Derman and Toy (1990) stochastic interest rate model, we find that the spread between fixed and variable rates of interest can be modeled (and priced) using an interest rate swap analogy. We also find that we can estimate an individual bank deposit yield curve as a spr...

  19. Next generation offline approaches to trace organic compound speciation: Approaching comprehensive speciation with soft ionization and very high resolution tandem mass spectrometry

    Science.gov (United States)

    Khare, P.; Marcotte, A.; Sheu, R.; Ditto, J.; Gentner, D. R.

    2017-12-01

    Intermediate- and semi-volatile organic compounds (IVOCs and SVOCs) have high secondary organic aerosol (SOA) yields, as well as significant ozone formation potentials. Yet, their emission sources and oxidation pathways remain largely understudied due to limitations in current analytical capabilities. Online mass spectrometers are able to collect real time data but their limited mass resolving power renders molecular level characterization of IVOCs and SVOCs from the unresolved complex mixture unfeasible. With proper sampling techniques and powerful analytical instrumentation, our offline tandem mass spectrometry (i.e. MS×MS) techniques provide molecular-level and structural identification over wide polarity and volatility ranges. We have designed a novel analytical system for offline analysis of gas-phase SOA precursors collected on custom-made multi-bed adsorbent tubes. Samples are desorbed into helium via a gradual temperature ramp and sample flow is split equally for direct-MS×MS analysis and separation via gas chromatography (GC). The effluent from GC separation is split again for analysis via atmospheric pressure chemical ionization quadrupole time-of-flight mass spectrometry (APCI-Q×TOF) and traditional electron ionization mass spectrometry (EI-MS). The compounds for direct-MS×MS analysis are delivered via a transfer line maintained at 70ºC directly to APCI-Q×TOF, thus preserving the molecular integrity of thermally-labile, or other highly-reactive, organic compounds. Both our GC-MS×MS and direct-MS×MS analyses report high accuracy parent ion masses as well as information on molecular structure via MS×MS, which together increase the resolution of unidentified complex mixtures. We demonstrate instrument performance and present preliminary results from urban atmospheric samples collected from New York City with a wide range of compounds including highly-functionalized organic compounds previously understudied in outdoor air. Our work offers new

  20. Color Comprehension and Color Categories among Blind Students: A Multi-Sensory Approach in Implementing Concrete Language to Include All Students in Advanced Writing Classes

    Science.gov (United States)

    Antarasena, Salinee

    2009-01-01

    This study investigates teaching methods regarding color comprehension and color categorization among blind students, as compared to their non-blind peers and whether they understand and represent the same color comprehension and color categories. Then after digit codes for color comprehension teaching and assistive technology for the blind had…

  1. An Approach to Precise Nitrogen Management Using Hand-Held Crop Sensor Measurements and Winter Wheat Yield Mapping in a Mediterranean Environment

    Directory of Open Access Journals (Sweden)

    Lucía Quebrajo

    2015-03-01

    Full Text Available Regardless of the crop production system, nutrients inputs must be controlled at or below a certain economic threshold to achieve an acceptable level of profitability. The use of management zones and variable-rate fertilizer applications is gaining popularity in precision agriculture. Many researchers have evaluated the application of final yield maps and geo-referenced geophysical measurements (e.g., apparent soil electrical conductivity-ECa as a method of establishing relatively homogeneous management zones within the same plot. Yield estimation models based on crop conditions at certain growth stages, soil nutrient statuses, agronomic factors, moisture statuses, and weed/pest pressures are a primary goal in precision agriculture. This study attempted to achieve the following objectives: (1 to investigate the potential for predicting winter wheat yields using vegetation measurements (the Normalized Difference Vegetation Index—NDVI at the beginning of the season, thereby allowing for a yield response to nitrogen (N fertilizer; and (2 evaluate the feasibility of using inexpensive optical sensor measurements in a Mediterranean environment. A field experiment was conducted in two commercial wheat fields near Seville, in southwestern Spain. Yield data were collected at harvest using a yield monitoring system (RDS Ceres II-volumetric meter installed on a combine. Wheat yield and NDVI values of 3498 ± 481 kg ha−1 and 0.67 ± 0.04 nm nm−1 (field 1 and 3221 ± 531 kg ha−1 and 0.68 ± 0.05 nm nm−1 (field 2 were obtained. In both fields, the yield and NDVI exhibited a strong Pearson correlation, with rxy = 0.64 and p < 10−4 in field 1 and rxy = 0.78 and p < 10−4 in field 2. The preliminary results indicate that hand-held crop sensor-based N management can be applied to wheat production in Spain and has the potential to increase agronomic N-use efficiency on a long-term basis.

  2. A comprehensive high-resolution mass spectrometry approach for characterization of metabolites by combination of ambient ionization, chromatography and imaging methods.

    Science.gov (United States)

    Berisha, Arton; Dold, Sebastian; Guenther, Sabine; Desbenoit, Nicolas; Takats, Zoltan; Spengler, Bernhard; Römpp, Andreas

    2014-08-30

    An ideal method for bioanalytical applications would deliver spatially resolved quantitative information in real time and without sample preparation. In reality these requirements can typically not be met by a single analytical technique. Therefore, we combine different mass spectrometry approaches: chromatographic separation, ambient ionization and imaging techniques, in order to obtain comprehensive information about metabolites in complex biological samples. Samples were analyzed by laser desorption followed by electrospray ionization (LD-ESI) as an ambient ionization technique, by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging for spatial distribution analysis and by high-performance liquid chromatography/electrospray ionization mass spectrometry (HPLC/ESI-MS) for quantitation and validation of compound identification. All MS data were acquired with high mass resolution and accurate mass (using orbital trapping and ion cyclotron resonance mass spectrometers). Grape berries were analyzed and evaluated in detail, whereas wheat seeds and mouse brain tissue were analyzed in proof-of-concept experiments. In situ measurements by LD-ESI without any sample preparation allowed for fast screening of plant metabolites on the grape surface. MALDI imaging of grape cross sections at 20 µm pixel size revealed the detailed distribution of metabolites which were in accordance with their biological function. HPLC/ESI-MS was used to quantify 13 anthocyanin species as well as to separate and identify isomeric compounds. A total of 41 metabolites (amino acids, carbohydrates, anthocyanins) were identified with all three approaches. Mass accuracy for all MS measurements was better than 2 ppm (root mean square error). The combined approach provides fast screening capabilities, spatial distribution information and the possibility to quantify metabolites. Accurate mass measurements proved to be critical in order to reliably combine data from different MS

  3. Spatial Heterogeneity of Leaf Area Index (LAI) and Its Temporal Course on Arable Land: Combining Field Measurements, Remote Sensing and Simulation in a Comprehensive Data Analysis Approach (CDAA)

    Science.gov (United States)

    Korres, Wolfgang; Montzka, Carsten; Fiener, Peter; Wilken, Florian; Stadler, Anja; Waldhoff, Guido; Schneider, Karl

    2016-01-01

    The ratio of leaf area to ground area (leaf area index, LAI) is an important state variable in ecosystem studies since it influences fluxes of matter and energy between the land surface and the atmosphere. As a basis for generating temporally continuous and spatially distributed datasets of LAI, the current study contributes an analysis of its spatial variability and spatial structure. Soil-vegetation-atmosphere fluxes of water, carbon and energy are nonlinearly related to LAI. Therefore, its spatial heterogeneity, i.e., the combination of spatial variability and structure, has an effect on simulations of these fluxes. To assess LAI spatial heterogeneity, we apply a Comprehensive Data Analysis Approach that combines data from remote sensing (5 m resolution) and simulation (150 m resolution) with field measurements and a detailed land use map. Test area is the arable land in the fertile loess plain of the Rur catchment on the Germany-Belgium-Netherlands border. LAI from remote sensing and simulation compares well with field measurements. Based on the simulation results, we describe characteristic crop-specific temporal patterns of LAI spatial variability. By means of these patterns, we explain the complex multimodal frequency distributions of LAI in the remote sensing data. In the test area, variability between agricultural fields is higher than within fields. Therefore, spatial resolutions less than the 5 m of the remote sensing scenes are sufficient to infer LAI spatial variability. Frequency distributions from the simulation agree better with the multimodal distributions from remote sensing than normal distributions do. The spatial structure of LAI in the test area is dominated by a short distance referring to field sizes. Longer distances that refer to soil and weather can only be derived from remote sensing data. Therefore, simulations alone are not sufficient to characterize LAI spatial structure. It can be concluded that a comprehensive picture of LAI spatial

  4. Evidence for a comprehensive approach to Aboriginal tobacco control to maintain the decline in smoking: an overview of reviews among Indigenous peoples.

    Science.gov (United States)

    Chamberlain, Catherine; Perlen, Susan; Brennan, Sue; Rychetnik, Lucie; Thomas, David; Maddox, Raglan; Alam, Noore; Banks, Emily; Wilson, Andrew; Eades, Sandra

    2017-07-10

    Tobacco smoking is a leading cause of disease and premature mortality among Aboriginal and Torres Strait Islander (Indigenous) Australians. While the daily smoking prevalence among Indigenous Australians has declined significantly from 49% in 2001, it remains about three times higher than that of non-Indigenous Australians (39 and 14%, respectively, for age ≥15 years in 2014-15). This overview of systematic reviews aimed to synthesise evidence about reducing tobacco consumption among Indigenous peoples using a comprehensive framework for Indigenous tobacco control in Australia comprised of the National Tobacco Strategy (NTS) and National Aboriginal and Torres Strait Islander Health Plan (NATSIHP) principles and priorities. MEDLINE, EMBASE, systematic review and Indigenous health databases were searched (2000 to Jan 2016) for reviews examining the effects of tobacco control interventions among Indigenous peoples. Two reviewers independently screened reviews, extracted data, and assessed review quality using Assessing the Methodological Quality of Systematic Reviews. Data were synthesised narratively by framework domain. Reporting followed the PRISMA statement. Twenty-one reviews of varying quality were included. There was generally limited Indigenous-specific evidence of effective interventions for reducing smoking; however, many reviewers recommended multifaceted interventions which incorporate Indigenous leadership, partnership and engagement and cultural tailoring. Under the NTS priority areas, reviewers reported evidence for brief smoking cessation interventions and pharmacological support, mass media campaigns (on knowledge and attitudes) and reducing affordability and regulation of tobacco sales. Aspects of intervention implementation related to the NATSIHP domains were less well described and evidence was limited; however, reviewers suggested that cultural tailoring, holistic approaches and building workforce capacity were important strategies to address

  5. Comprehension Strategy Gloves.

    Science.gov (United States)

    Newman, Gayle

    2002-01-01

    Describes the idea of creating a glove for each of the comprehension strategies for use with different text structures. Notes that the gloves serve as a multisensory approach by providing visual clues through icons on each finger and the palm. Discusses three different gloves: the prereading glove, the narrative text structure glove, and the…

  6. A comprehensive approach for the simulation of the Urban Heat Island effect with the WRF/SLUCM modeling system: The case of Athens (Greece)

    Science.gov (United States)

    Giannaros, Christos; Nenes, Athanasios; Giannaros, Theodore M.; Kourtidis, Konstantinos; Melas, Dimitrios

    2018-03-01

    This study presents a comprehensive modeling approach for simulating the spatiotemporal distribution of urban air temperatures with a modeling system that includes the Weather Research and Forecasting (WRF) model and the Single-Layer Urban Canopy Model (SLUCM) with a modified treatment of the impervious surface temperature. The model was applied to simulate a 3-day summer heat wave event over the city of Athens, Greece. The simulation, using default SLUCM parameters, is capable of capturing the observed diurnal variation of urban temperatures and the Urban Heat Island (UHI) in the greater Athens Area (GAA), albeit with systematic biases that are prominent during nighttime hours. These biases are particularly evident over low-intensity residential areas, and they are associated with the surface and urban canopy properties representing the urban environment. A series of sensitivity simulations unravels the importance of the sub-grid urban fraction parameter, surface albedo, and street canyon geometry in the overall causation and development of the UHI effect. The sensitivities are then used to determine optimal values of the street canyon geometry, which reproduces the observed temperatures throughout the simulation domain. The optimal parameters, apart from considerably improving model performance (reductions in mean temperature bias from 0.30 °C to 1.58 °C), are also consistent with actual city building characteristics - which gives confidence that the model set-up is robust, and can be used to study the UHI in the GAA in the anticipated warmer conditions in the future.

  7. Laparoscopic splenectomy is a better surgical approach for spleen-relevant disorders: a comprehensive meta-analysis based on 15-year literatures.

    Science.gov (United States)

    Cheng, Ji; Tao, Kaixiong; Yu, Peiwu

    2016-10-01

    Currently, whether laparoscopic or open splenectomy is a gold standard option for spleen abnormalities remains in controversy. There is in deficiency of academic evidence concerning the surgical efficacy and safety of both comparative managements. In order to surgically appraise the applied potentials of both approaches, we hence performed this comprehensive meta-analysis on the basis of 15-year literatures. Via searching of PubMed, EMBASE, Web of Science, and Cochrane Library databases, overall 37 original articles were eligibly incorporated into our meta-analysis and subdivided into six sections. In accordance with the Cochrane Collaboration protocol, all statistical procedures were mathematically conducted in a standard manner. Publication bias was additionally evaluated by funnel plot and Egger's test. Irrespective of the diversified splenic disorders, laparoscopic splenectomy was superior to open technique owing to its fewer estimated blood loss, shorter postoperative hospital stay as well as lower complication rate (P  0.05). Technically, laparoscopic splenectomy should be recommended as a prior remedy with its advantage of rapid recovery and minimally physical damage, in addition to its comparably surgical efficacy against that of open manipulation.

  8. Methodological approaches to perform a site specific PSA on the effects of comprehensive events; Methodische Ansaetze zur Durchfuehrung einer standortspezifischen PSA zu den Auswirkungen uebergreifender Einwirkungen

    Energy Technology Data Exchange (ETDEWEB)

    Tuerschmann, Michael; Sperbeck, Silvio; Frey, Walter

    2016-12-15

    Main objective of the project 3612R01550 performed on behalf of the Federal Ministry for the Environment, Nature Conservation, Building and Nuclear Safety (BMUB) is the development of an approach for systematic consideration of dependencies in case of internal and external hazards and their combinations in the probabilistic plant model for nuclear power plants. One of the major aspects of a site specific Level 1 PSA carried out for a nuclear power plant outlined in this report is taking comprehensively into account the entire risks resulting from internal and external hazards. In a first step, all the hazards which may occur at the site under investigation have to be identified. This requires a compilation of the potential hazards and their possible combinations: Based on this compilation of generic hazards a site specific list of hazards to be considered in the analysis can be derived based on a screening process taking into account regulatory requirements and insights from site and plant walk-downs. In a second step, the hazards to be considered for the specific site have to be classified with respect to the depth of the probabilistic analyses to be carried out. This classification covers three categories: hazards with a negligible contribution to the overall risk, hazards with such a low risk contribution that a rough quantitative assessment is sufficient, and hazards which need in-depth probabilistic analysis. Based on the available Level 1 PSA model for internal events, a systematic approach for in-depth probabilistic analyses of hazards and their combinations is proposed. In this context, lists of those structures, systems and components, which can be impaired in their required function resulting in a risk increase, are provided. One of these lists contains the equipment, the other one the dependencies to be considered for the corresponding hazard. In addition to the general approach for performing site specific PSA, a procedure for modelling dependencies in

  9. Comprehensive examination of conventional and innovative body fluid identification approaches and DNA profiling of laundered blood- and saliva-stained pieces of cloths.

    Science.gov (United States)

    Kulstein, G; Wiegand, P

    2018-01-01

    Body fluids like blood and saliva are commonly encountered during investigations of high volume crimes like homicides. The identification of the cellular origin and the composition of the trace can link suspects or victims to a certain crime scene and provide a probative value for criminal investigations. To erase all traces from the crime scene, perpetrators often wash away their traces. Characteristically, items that show exposed stains like blood are commonly cleaned or laundered to free them from potential visible leftovers. Mostly, investigators do not delegate the DNA analysis of laundered items. However, some studies have already revealed that items can still be used for DNA analysis even after they have been laundered. Nonetheless, a systematical evaluation of laundered blood and saliva traces that provides a comparison of different established and newly developed methods for body fluid identification (BFI) is still missing. Herein, we present the results of a comprehensive study of laundered blood- and saliva-stained pieces of cloths that were applied to a broad range of methods for BFI including conventional approaches as well as molecular mRNA profiling. The study included the evaluation of cellular origin as well as DNA profiling of blood- and saliva-stained (synthetic fiber and cotton) pieces of cloths, which have been washed at various washing temperatures for one or multiple times. Our experiments demonstrate that, while STR profiling seems to be sufficiently sensitive for the individualization of laundered items, there is a lack of approaches for BFI with the same sensitivity and specificity allowing to characterize the cellular origin of challenging, particularly laundered, blood and saliva samples.

  10. A comprehensive approach to identify reliable reference gene candidates to investigate the link between alcoholism and endocrinology in Sprague-Dawley rats.

    Directory of Open Access Journals (Sweden)

    Faten A Taki

    Full Text Available Gender and hormonal differences are often correlated with alcohol dependence and related complications like addiction and breast cancer. Estrogen (E2 is an important sex hormone because it serves as a key protein involved in organism level signaling pathways. Alcoholism has been reported to affect estrogen receptor signaling; however, identifying the players involved in such multi-faceted syndrome is complex and requires an interdisciplinary approach. In many situations, preliminary investigations included a straight forward, yet informative biotechniques such as gene expression analyses using quantitative real time PCR (qRT-PCR. The validity of qRT-PCR-based conclusions is affected by the choice of reliable internal controls. With this in mind, we compiled a list of 15 commonly used housekeeping genes (HKGs as potential reference gene candidates in rat biological models. A comprehensive comparison among 5 statistical approaches (geNorm, dCt method, NormFinder, BestKeeper, and RefFinder was performed to identify the minimal number as well the most stable reference genes required for reliable normalization in experimental rat groups that comprised sham operated (SO, ovariectomized rats in the absence (OVX or presence of E2 (OVXE2. These rat groups were subdivided into subgroups that received alcohol in liquid diet or isocalroic control liquid diet for 12 weeks. Our results showed that U87, 5S rRNA, GAPDH, and U5a were the most reliable gene candidates for reference genes in heart and brain tissue. However, different gene stability ranking was specific for each tissue input combination. The present preliminary findings highlight the variability in reference gene rankings across different experimental conditions and analytic methods and constitute a fundamental step for gene expression assays.

  11. Evaluating differential nuclear DNA yield rates and osteocyte numbers among human bone tissue types: A synchrotron radiation micro-CT approach.

    Science.gov (United States)

    Andronowski, Janna M; Mundorff, Amy Z; Pratt, Isaac V; Davoren, Jon M; Cooper, David M L

    2017-05-01

    Molecular human identification has conventionally focused on DNA sampling from dense, weight-bearing cortical bone tissue, typically from femora or tibiae. A comparison of skeletal elements from three contemporary individuals demonstrated that elements with high quantities of cancellous bone yielded nuclear DNA at the highest rates, suggesting that preferentially sampling cortical bone may be suboptimal (Mundorff & Davoren, 2014). Despite these findings, the reason for the differential DNA yields between cortical and cancellous bone tissues remains unknown. The primary goal of this work is to ascertain whether differences in bone microstructure can be used to explain differential nuclear DNA yield among bone tissue types observed by Mundorff and Davoren (2014), with a focus on osteocytes and the three-dimensional (3D) quantification of their associated lacunae. Osteocytes and other bone cells are recognized to house DNA in bone tissue, thus examining the density of their lacunae may explain why nuclear DNA yield rates differ among bone tissue types. Lacunae were visualized and quantified using synchrotron radiation-based micro-Computed Tomographic imaging (SR micro-CT). Volumes of interest (VOIs) from cortical and cancellous bone tissues (n=129) were comparatively analyzed from the three skeletons sampled for Mundorff and Davoren's (2014) study. Analyses tested the primary hypothesis that the abundance and density of osteocytes (inferred from their lacunar spaces) vary between cortical and cancellous bone tissue types. Results demonstrated that osteocyte lacunar abundance and density vary between cortical and cancellous bone tissue types, with cortical bone VOIs containing a higher lacunar abundance and density. We found that the osteocyte lacunar density values are independent of nuclear DNA yield, suggesting an alternative explanation for the higher nuclear DNA yields from bones with greater quantities of cancellous bone tissue. The use of SR micro-CT allowed for

  12. Changes in water budgets and sediment yields from a hypothetical agricultural field as a function of landscape and management characteristics--A unit field modeling approach

    Science.gov (United States)

    Roth, Jason L.; Capel, Paul D.

    2012-01-01

    Crop agriculture occupies 13 percent of the conterminous United States. Agricultural management practices, such as crop and tillage types, affect the hydrologic flow paths through the landscape. Some agricultural practices, such as drainage and irrigation, create entirely new hydrologic flow paths upon the landscapes where they are implemented. These hydrologic changes can affect the magnitude and partitioning of water budgets and sediment erosion. Given the wide degree of variability amongst agricultural settings, changes in the magnitudes of hydrologic flow paths and sediment erosion induced by agricultural management practices commonly are difficult to characterize, quantify, and compare using only field observations. The Water Erosion Prediction Project (WEPP) model was used to simulate two landscape characteristics (slope and soil texture) and three agricultural management practices (land cover/crop type, tillage type, and selected agricultural land management practices) to evaluate their effects on the water budgets of and sediment yield from agricultural lands. An array of sixty-eight 60-year simulations were run, each representing a distinct natural or agricultural scenario with various slopes, soil textures, crop or land cover types, tillage types, and select agricultural management practices on an isolated 16.2-hectare field. Simulations were made to represent two common agricultural climate regimes: arid with sprinkler irrigation and humid. These climate regimes were constructed with actual climate and irrigation data. The results of these simulations demonstrate the magnitudes of potential changes in water budgets and sediment yields from lands as a result of landscape characteristics and agricultural practices adopted on them. These simulations showed that variations in landscape characteristics, such as slope and soil type, had appreciable effects on water budgets and sediment yields. As slopes increased, sediment yields increased in both the arid and

  13. Digging beneath the Surface Behavioral and Neural Indices of Lexical Access during Idiom Comprehension in Aphasia: A Multi-Modal Approach

    Science.gov (United States)

    Brumm, Kathleen Patricia

    2011-01-01

    This project examines spoken language comprehension in Broca's aphasia, a non-fluent language disorder acquired subsequent to stroke. Broca's aphasics demonstrate impaired comprehension for complex sentence constructions. To account for this deficit, one current processing theory claims that Broca's patients retain intrinsic linguistic knowledge,…

  14. A comprehensive complex systems approach to the study and analysis of mammalian cell cycle control system in the presence of DNA damage stress.

    Science.gov (United States)

    Abroudi, Ali; Samarasinghe, Sandhya; Kulasiri, Don

    2017-09-21

    Not many models of mammalian cell cycle system exist due to its complexity. Some models are too complex and hard to understand, while some others are too simple and not comprehensive enough. Moreover, some essential aspects, such as the response of G1-S and G2-M checkpoints to DNA damage as well as the growth factor signalling, have not been investigated from a systems point of view in current mammalian cell cycle models. To address these issues, we bring a holistic perspective to cell cycle by mathematically modelling it as a complex system consisting of important sub-systems that interact with each other. This retains the functionality of the system and provides a clearer interpretation to the processes within it while reducing the complexity in comprehending these processes. To achieve this, we first update a published ODE mathematical model of cell cycle with current knowledge. Then the part of the mathematical model relevant to each sub-system is shown separately in conjunction with a diagram of the sub-system as part of this representation. The model sub-systems are Growth Factor, DNA damage, G1-S, and G2-M checkpoint signalling. To further simplify the model and better explore the function of sub-systems, they are further divided into modules. Here we also add important new modules of: chk-related rapid cell cycle arrest, p53 modules expanded to seamlessly integrate with the rapid arrest module, Tyrosine phosphatase modules that activate Cyc_Cdk complexes and play a crucial role in rapid and delay arrest at both G1-S and G2-M, Tyrosine Kinase module that is important for inactivating nuclear transport of CycB_cdk1 through Wee1 to resist M phase entry, Plk1-Related module that is crucial in activating Tyrosine phosphatases and inactivating Tyrosine kinase, and APC-Related module to show steps in CycB degradation. This multi-level systems approach incorporating all known aspects of cell cycle allowed us to (i) study, through dynamic simulation of an ODE model

  15. Evaluation of a comprehensive EHR based on the DeLone and McLean model for IS success: approach, results, and success factors.

    Science.gov (United States)

    Bossen, Claus; Jensen, Lotte Groth; Udsen, Flemming Witt

    2013-10-01

    The article describes the methodological approach to, and results of an evaluation of a comprehensive electronic health record (EHR) in the shake down phase, shortly after its implementation at a regional hospital in Denmark. A formative evaluation based on a mixed-methods case study, designed to be interactive and concurrent was conducted at two hospital departments based on the updated DeLone and McLean framework for evaluating information systems success. To ascertain user assessments of the EHR, we distributed a questionnaire two months after implementation to four groups of staff (physicians, nurses, medical secretaries, and physiotherapists; n=244), and at the same time we conducted thirteen individual, semi-structured interviews with representatives from these four groups. Subsequently, seven follow-up focus group interviews were conducted with the four above-mentioned groups, in order to go deeper into specific user assessments. Simultaneously, focus group interviews with two IT departments and the implementation team were conducted, to gain insight into system provider assessments of the implementation process and the EHR. Before, during, and after implementation, 88 h of ethnographic observation were carried out, to give the researchers an understanding of the daily routine of staff, and their use of health records. Finally, daily system performance data were obtained, to gather factual information on system response and downtime. Overall, staff had positive experiences with the EHR and its operational reliability, response time, login and support. Performance was acceptable. Medical secretaries found the use of the patient administration module cumbersome, and physicians found the establishment of the overview of professionally relevant data challenging. There were demands for improvements to these and other functionalities, and for the EHR to be integrated with other systems and databases. Evaluations immediately following implementation are inherently

  16. A comprehensive approach to identify dominant controls of the behavior of a land surface-hydrology model across various hydroclimatic conditions

    Science.gov (United States)

    Haghnegahdar, Amin; Elshamy, Mohamed; Yassin, Fuad; Razavi, Saman; Wheater, Howard; Pietroniro, Al

    2017-04-01

    Complex physically-based environmental models are being increasingly used as the primary tool for watershed planning and management due to advances in computation power and data acquisition. Model sensitivity analysis plays a crucial role in understanding the behavior of these complex models and improving their performance. Due to the non-linearity and interactions within these complex models, Global sensitivity analysis (GSA) techniques should be adopted to provide a comprehensive understanding of model behavior and identify its dominant controls. In this study we adopt a multi-basin multi-criteria GSA approach to systematically assess the behavior of the Modélisation Environmentale-Surface et Hydrologie (MESH) across various hydroclimatic conditions in Canada including areas in the Great Lakes Basin, Mackenzie River Basin, and South Saskatchewan River Basin. MESH is a semi-distributed physically-based coupled land surface-hydrology modelling system developed by Environment and Climate Change Canada (ECCC) for various water resources management purposes in Canada. We use a novel method, called Variogram Analysis of Response Surfaces (VARS), to perform sensitivity analysis. VARS is a variogram-based GSA technique that can efficiently provide a spectrum of sensitivity information across a range of scales within the parameter space. We use multiple metrics to identify dominant controls of model response (e.g. streamflow) to model parameters under various conditions such as high flows, low flows, and flow volume. We also investigate the influence of initial conditions on model behavior as part of this study. Our preliminary results suggest that this type of GSA can significantly help with estimating model parameters, decreasing calibration computational burden, and reducing prediction uncertainty.

  17. The in situ side-to-side bypass technique: a comprehensive review of the technical characteristics, current anastomosis approaches and surgical experience.

    Science.gov (United States)

    Wang, Long; Cai, Li; Qian, Hai; Lawton, Michael T; Shi, Xiang'en

    2018-05-02

    In situ side-to-side (STS) revascularization is an intracranial-intracranial (IC-IC) bypass technique that is increasingly used to treat complex aneurysms and cerebral ischemia. This sophisticated technique involves connecting two proximal parallel vessels to create an artificial conduit for blood flow. This study aims to provide a detailed description of the configuration of the STS bypass technique and extensive information regarding its technical characteristics, current anastomosis approaches and surgical significance. A literature search was performed using the PubMed, Medline, ScienceDirect, Embase, Wiley Online Library, Cambridge Journals, SAGE Journals, Oxford Journals, Research Gate, and Google Scholar databases. The terms "intracranial-intracranial bypass", "in situ bypass", "communicating bypass" and "STS anastomosis" were searched to identify pertinent articles. Articles involving in situ STS anastomosis combined with other bypass methods were excluded. Computer tablet-drawn illustrations of this technique are provided to enhance comprehension. In total, seventy articles that met our search and inclusion criteria were identified. Overall, the radiographical and clinical outcomes of one-hundred and thirty-two (125 aneurysm and 7 cerebral ischemia) patients who underwent in situ STS revascularization were analyzed. IC-IC bypass in the STS fashion can be a safe and effective strategy for the management of complex intracranial aneurysms and cerebral ischemia and is particularly attractive in rescue, anticipated and troubleshooting cases. Despite its extreme rarity, a de novo aneurysm may be observed following STS anastomosis; thus, long-term follow-up is mandatory. Vascular neurosurgeons should consider including this procedure in their treatment armamentarium. Copyright © 2018. Published by Elsevier Inc.

  18. Towards a comprehensive X-ray approach for studying the photosynthetic manganese complex-XANES, K{alpha}/K{beta}/K{beta}-satellite emission lines, RIXS, and comparative computational approaches for selected model complexes

    Energy Technology Data Exchange (ETDEWEB)

    Zaharieva, I; Chernev, P; Risch, M; Gerencser, L; Haumann, M; Dau, H [Free University Berlin, FB Physik, Arnimallee 14, D-14195 Berlin (Germany); Berggren, G; Shevchenko, D; Anderlund, M [Dept. of Photochemistry and Molecular Science, Uppsala University, Box 523, S-751 20 Uppsala (Sweden); Weng, T C, E-mail: holger.dau@fu-berlin.d, E-mail: michael.haumann@fu-berlin.d [European Synchrotron Radiation Facility, BP 220, F-38043 Grenoble Cedex (France)

    2009-11-15

    Advanced X-ray spectroscopy experiments can contribute to elucidation of the mechanism of water oxidation in biological (tetra-manganese complex of Photosystem II) and artificial systems. Although the electronic structure of the catalytic metal site is of high interest, it is experimentally not easily accessible. Therefore, we and other researchers are working towards a comprehensive approach involving a combination of methods, namely (1) quantitative analysis of X-ray absorption near-edge structure (XANES) spectra collected at the K-edge and, in the long run, at the L-edge of manganese; (2) high-resolution X-ray emission spectroscopy (XES) of K{alpha} and K{beta} lines, (3) two-dimensional resonant inelastic X-ray scattering (RIXS) spectra. Collection of these spectroscopic data sets requires state-of-the-art synchrotron radiation facilities as well as experimental strategies to minimize the radiation-induced modifications of the samples. Data analysis requires the use and development of appropriate theoretical tools. Here, we present exemplary data collected for three multi-nuclear synthetic Mn complexes with the Mn ions in the oxidation states II, III, and IV, and for Mn{sup VII} of the permanganate ion. Emission spectra are calculated for the Mn{sup VII} ion using both multiple-scattering (MS) approach and time-dependent density functional theory (TDDFT).

  19. Yield enhancement with DFM

    Science.gov (United States)

    Paek, Seung Weon; Kang, Jae Hyun; Ha, Naya; Kim, Byung-Moo; Jang, Dae-Hyun; Jeon, Junsu; Kim, DaeWook; Chung, Kun Young; Yu, Sung-eun; Park, Joo Hyun; Bae, SangMin; Song, DongSup; Noh, WooYoung; Kim, YoungDuck; Song, HyunSeok; Choi, HungBok; Kim, Kee Sup; Choi, Kyu-Myung; Choi, Woonhyuk; Jeon, JoongWon; Lee, JinWoo; Kim, Ki-Su; Park, SeongHo; Chung, No-Young; Lee, KangDuck; Hong, YoungKi; Kim, BongSeok

    2012-03-01

    A set of design for manufacturing (DFM) techniques have been developed and applied to 45nm, 32nm and 28nm logic process technologies. A noble technology combined a number of potential confliction of DFM techniques into a comprehensive solution. These techniques work in three phases for design optimization and one phase for silicon diagnostics. In the DFM prevention phase, foundation IP such as standard cells, IO, and memory and P&R tech file are optimized. In the DFM solution phase, which happens during ECO step, auto fixing of process weak patterns and advanced RC extraction are performed. In the DFM polishing phase, post-layout tuning is done to improve manufacturability. DFM analysis enables prioritization of random and systematic failures. The DFM technique presented in this paper has been silicon-proven with three successful tape-outs in Samsung 32nm processes; about 5% improvement in yield was achieved without any notable side effects. Visual inspection of silicon also confirmed the positive effect of the DFM techniques.

  20. Towards a comprehensive understanding of emerging dynamics and function of pancreatic islets: A complex network approach. Comment on "Network science of biological systems at different scales: A review" by Gosak et al.

    Science.gov (United States)

    Loppini, Alessandro

    2018-03-01

    Complex network theory represents a comprehensive mathematical framework to investigate biological systems, ranging from sub-cellular and cellular scales up to large-scale networks describing species interactions and ecological systems. In their exhaustive and comprehensive work [1], Gosak et al. discuss several scenarios in which the network approach was able to uncover general properties and underlying mechanisms of cells organization and regulation, tissue functions and cell/tissue failure in pathology, by the study of chemical reaction networks, structural networks and functional connectivities.

  1. A phenotypical approach to the effects of production traits, parturition, puerperium and body condition on commencement of luteal activity in high yielding dairy cows.

    Science.gov (United States)

    Boldt, Ariane; Becker, Frank; Martin, Gunter; Nürnberg, Gerd; Römer, Anke; Kanitz, Wilhelm

    2015-06-01

    The interval from calving to commencement of luteal activity (CLA) was determined by progesterone measurements from milk samples obtained once a week until the 14th week post-partum in 513 German Holstein cows in first to third parity. Milk samples were analyzed by an "on-farm" device (eProCheck(®), Minitüb, Germany) and simultaneously by RIA. The objective of this study was to examine the effect of milk yield, protein content and body condition of a cow on the CLA post-partum. Milk progesterone concentrations of "on-farm" measurements correlated with measurements done by the RIA-method significantly (r=0.72; PCows with a milk protein content at 1st milk recording of ≤3.5% revealed first luteal activity 1.3±0.3 weeks later than cows that had a content of >3.75% protein (Pcows with assisted calving or dystocia presented significantly later CLA than cows which required no help during the calving process (Pfertility cannot be confirmed regarding to CLA. The negative energy balance after calving, caused by the high milk yields, is more detrimental for the cyclical activity as was shown by the parameters milk protein content and change in BFT. Copyright © 2015 Elsevier B.V. All rights reserved.

  2. 501 reading comprehension questions

    CERN Document Server

    2014-01-01

    This updated edition offers the most extensive and varied practice for all types of questions students might face on standardized and in-class tests. With this guide, students will learn to develop expert reading strategies, understand how to read faster and with greater comprehension, overcome reading anxiety, and increase appreciation of reading for pleasure. This book's step-by-step approach provides graduated coverage that moves from the basics to more advanced reading.

  3. The safety culture according to a comprehensive approach. A contribution to risk governance within complex systems. Doctoral thesis prepared at SCK-CEN and defended in 2004

    International Nuclear Information System (INIS)

    Fucks, I.

    2005-01-01

    The article refers to an abstract of a doctoral thesis. This PhD is based on two evolutions within the society concerning the way to manage modern risks. It is more and more acknowledged that, firstly, rational scientific models are no longer capable to explain and manage the complexity and the diversity of risks. Secondly the supporters of a democratic conception of the risk governance claim that the risk management can benefit from the participation of the lay people to the debate. Within this framework, the study of safety culture, according to a bottom-up and comprehensive approach, in the field of the social sciences, represents an opportunity to make concrete the risk governance principle within complex system (such as a nuclear power plant and a nuclear research centre). The objectives of this PhD are the following: to appreciate the participation of the workers to the debate of the risk management within organisations; to present the lessons which can be drawn from this exercise and finally to investigate the safety culture of different groups of workers adopting an alternative view as compared to the vision as formulated in the present texts of the IAEA.The methodology was based on two techniques: observation and Focus Group. The observations were planed to feed further the Focus Group discussions with concrete examples of situations at work. We organized different Focus Group discussions with different kinds of workers (workers, managers, safety officers) in order to collect the social representation relating to the safety, the organization, the technology, the socio-economical environment and the work of each of these groups, both in the Belgian Nuclear Research Centre and in the Nuclear Power Plant of Tricastin in France. The results confirm firstly the relevance of developing a multidisciplinary theoretical framework of safety culture drawing its inspiration from sociology, social psychology, anthropology, etc. This multidisciplinary approach allows

  4. Roles of linguistic knowledge, metacognitive knowledge and processing speed in L3, L2 and L1 reading comprehension: a structural equation modeling approach

    NARCIS (Netherlands)

    van Gelderen, A.; Schoonen, R.; de Glopper, K.; Hulstijn, J.; Snellings, P.; Simis, A.; Stevenson, M.

    2003-01-01

    In this article we present an analysis of the relationship between L3 reading comprehension and its constituent skills for bilingual Dutch students for whom English is a third language(L3) compared to monolingual Dutch students for whom English is a second language(L2). An analogous analysis is made

  5. Validity limits in J-resistance curve determination: A computational approach to ductile crack growth under large-scale yielding conditions. Volume 2

    International Nuclear Information System (INIS)

    Shih, C.F.; Xia, L.; Hutchinson, J.W.

    1995-02-01

    In this report, Volume 2, Mode I crack initiation and growth under plane strain conditions in tough metals are computed using an elastic/plastic continuum model which accounts for void growth and coalescence ahead of the crack tip. The material parameters include the stress-strain properties, along with the parameters characterizing the spacing and volume fraction of voids in material elements lying in the plane of the crack. For a given set of these parameters and a specific specimen, or component, subject to a specific loading, relationships among load, load-line displacement and crack advance can be computed with no restrictions on the extent of plastic deformation. Similarly, there is no limit on crack advance, except that it must take place on the symmetry plane ahead of the initial crack. Suitably defined measures of crack tip loading intensity, such as those based on the J-integral, can also be computed, thereby directly generating crack growth resistance curves. In this report, the model is applied to five specimen geometries which are known to give rise to significantly different crack tip constraints and crack growth resistance behaviors. Computed results are compared with sets of experimental data for two tough steels for four of the specimen types. Details of the load, displacement and crack growth histories are accurately reproduced, even when extensive crack growth takes place under conditions of fully plastic yielding. A description of material resistance to crack initiation and subsequent growth is essential for assessing structural integrity such as nuclear pressure vessels and piping

  6. 6 Grain Yield

    African Journals Online (AJOL)

    create a favourable environment for rice ... developing lines adaptable to many ... have stable, not too short crop duration with ..... Analysis of variance of the effect of site and season on maturity, grain yield and plant ..... and yield components.

  7. Prediction of gasoline yield in a fluid catalytic cracking (FCC riser using k-epsilon turbulence and 4-lump kinetic models: A computational fluid dynamics (CFD approach

    Directory of Open Access Journals (Sweden)

    Muhammad Ahsan

    2015-07-01

    Full Text Available Fluid catalytic cracking (FCC is an essential process for the conversion of gas oil to gasoline. This study is an effort to model the phenomenon numerically using commercial computational fluid dynamics (CFD software, heavy density catalyst and 4-lump kinetic model. Geometry, boundary conditions and dimensions of industrial riser for catalytic cracking unit are conferred for 2D simulation using commercial CFD code FLUENT 6.3. Continuity, momentum, energy and species transport equations, applicable to two phase solid and gas flow, are used to simulate the physical phenomenon as efficient as possible. This study implements and predicts the use of the granular Eulerian multiphase model with species transport. Time accurate transient problem is solved with the prediction of mass fraction profiles of gas oil, gasoline, light gas and coke. The output curves demonstrate the breaking of heavy hydrocarbon in the presence of catalyst. An approach proposed in this study shows good agreement with the experimental and numerical data available in the literature.

  8. Yield stress fluids slowly yield to analysis

    NARCIS (Netherlands)

    Bonn, D.; Denn, M.M.

    2009-01-01

    We are surrounded in everyday life by yield stress fluids: materials that behave as solids under small stresses but flow like liquids beyond a critical stress. For example, paint must flow under the brush, but remain fixed in a vertical film despite the force of gravity. Food products (such as

  9. Yield Stability in Winter Wheat Production: A Survey on German Farmers’ and Advisors’ Views

    Directory of Open Access Journals (Sweden)

    Janna Macholdt

    2017-06-01

    Full Text Available Most of the available research studies have focused on the production of high grain yields of wheat and have neglected yield stability. However, yield stability is a relevant factor in agronomic practice and, therefore, is the focus of this comprehensive survey. The aim was to first describe the importance of yield stability as well as currently used practical management strategies that ensure yield stability in wheat production and secondly, to obtain potential research areas supporting yield stability in the complex system of agronomy. The target groups were German farmers with experience in wheat production and advisors with expertise in the field of wheat cultivation or research. A sample size of 615 completed questionnaires formed the data basis of this study. The study itself provides evidence that the yield stability of winter wheat is even more important than the amount of yield for a large proportion of farmers (48% and advisors (47%. Furthermore, in the view of the majority of the surveyed farmers and advisors, yield stability is gaining importance in climate change. Data analysis showed that site adapted cultivar choice, favorable crop rotations and integrated plant protection are ranked as three of the most important agronomic management practices to achieve high yield stability of wheat. Soil tillage and fertilization occupied a middle position, whereas sowing date and sowing density were estimated with lower importance. However, yield stability is affected by many environmental, genetic and agronomic factors, which subsequently makes it a complex matter. Hence, yield stability in farming practice must be analyzed and improved in a systems approach.

  10. Comprehensive Psychiatric Evaluation

    Science.gov (United States)

    ... Facts for Families Guide Facts for Families - Vietnamese Comprehensive Psychiatric Evaluation No. 52; Updated October 2017 Evaluation ... with serious emotional and behavioral problems need a comprehensive psychiatric evaluation. Comprehensive psychiatric evaluations usually require a ...

  11. Children's hypertext comprehension

    NARCIS (Netherlands)

    Segers, P.C.J.; Segers, E.; Broek, P. van den

    2017-01-01

    The present chapter gives an overview of the literature on hypertext comprehension, children's hypertext comprehension and individual variation therein, ending with a perspective for future research. Hypertext comprehension requires the reader to make bridging inferences between the different parts

  12. Ranking Medical Terms to Support Expansion of Lay Language Resources for Patient Comprehension of Electronic Health Record Notes: Adapted Distant Supervision Approach.

    Science.gov (United States)

    Chen, Jinying; Jagannatha, Abhyuday N; Fodeh, Samah J; Yu, Hong

    2017-10-31

    Medical terms are a major obstacle for patients to comprehend their electronic health record (EHR) notes. Clinical natural language processing (NLP) systems that link EHR terms to lay terms or definitions allow patients to easily access helpful information when reading through their EHR notes, and have shown to improve patient EHR comprehension. However, high-quality lay language resources for EHR terms are very limited in the public domain. Because expanding and curating such a resource is a costly process, it is beneficial and even necessary to identify terms important for patient EHR comprehension first. We aimed to develop an NLP system, called adapted distant supervision (ADS), to rank candidate terms mined from EHR corpora. We will give EHR terms ranked as high by ADS a higher priority for lay language annotation-that is, creating lay definitions for these terms. Adapted distant supervision uses distant supervision from consumer health vocabulary and transfer learning to adapt itself to solve the problem of ranking EHR terms in the target domain. We investigated 2 state-of-the-art transfer learning algorithms (ie, feature space augmentation and supervised distant supervision) and designed 5 types of learning features, including distributed word representations learned from large EHR data for ADS. For evaluating ADS, we asked domain experts to annotate 6038 candidate terms as important or nonimportant for EHR comprehension. We then randomly divided these data into the target-domain training data (1000 examples) and the evaluation data (5038 examples). We compared ADS with 2 strong baselines, including standard supervised learning, on the evaluation data. The ADS system using feature space augmentation achieved the best average precision, 0.850, on the evaluation set when using 1000 target-domain training examples. The ADS system using supervised distant supervision achieved the best average precision, 0.819, on the evaluation set when using only 100 target

  13. Bond yield curve construction

    Directory of Open Access Journals (Sweden)

    Kožul Nataša

    2014-01-01

    Full Text Available In the broadest sense, yield curve indicates the market's view of the evolution of interest rates over time. However, given that cost of borrowing it closely linked to creditworthiness (ability to repay, different yield curves will apply to different currencies, market sectors, or even individual issuers. As government borrowing is indicative of interest rate levels available to other market players in a particular country, and considering that bond issuance still remains the dominant form of sovereign debt, this paper describes yield curve construction using bonds. The relationship between zero-coupon yield, par yield and yield to maturity is given and their usage in determining curve discount factors is described. Their usage in deriving forward rates and pricing related derivative instruments is also discussed.

  14. Measurements of fission yields

    International Nuclear Information System (INIS)

    Denschlag, H.O.

    2000-01-01

    After some historical introductory remarks on the discovery of nuclear fission and early fission yield determinations, the present status of knowledge on fission yields is briefly reviewed. Practical and fundamental reasons motivating the pursuit of fission yield measurements in the coming century are pointed out. Recent results and novel techniques are described that promise to provide new interesting insights into the fission process during the next century. (author)

  15. NIF total neutron yield diagnostic

    International Nuclear Information System (INIS)

    Cooper, Gary W.; Ruiz, Carlos L.

    2001-01-01

    We have designed a total neutron yield diagnostic for the National Ignition Facility (NIF) which is based on the activation of In and Cu samples. The particular approach that we have chosen is one in which we calibrate the entire counting system and which we call the ''F factor'' method. In this method, In and/or Cu samples are exposed to known sources of DD and DT neutrons. The activated samples are then counted with an appropriate system: a high purity Ge detector for In and a NaI coincidence system for Cu. We can then calculate a calibration factor, which relates measured activity to total neutron yield. The advantage of this approach is that specific knowledge of such quantities as cross sections and detector efficiencies is not needed. Unless the actual scattering environment of the NIF can be mocked up in the calibration experiment, the F factor will have to be modified using the results of a numerical simulation of the NIF scattering environment. In this article, the calibration factor methodology will be discussed and experimental results for the calibration factors will be presented. Total NIF neutron yields of 10 9 --10 19 can be measured with this method assuming a 50 cm stand-off distance can be employed for the lower yields

  16. A comprehensive approach to environmental and human factors into product/service design and development. A review from an ergoecological perspective.

    Science.gov (United States)

    Saravia-Pinilla, Martha H; Daza-Beltrán, Carolina; García-Acosta, Gabriel

    2016-11-01

    This article presents the results of a documentary-exploratory review of design methods and concepts associated with human and environmental factors, based on a qualitative-quantitative analysis of coincidences with the fundamentals of ergoecology and in line with sustainable dynamics, with a view to putting the principles of ergoecology into practice in product/service design and development. 61.6% of 696 documents found represent work on conceptual developments, while the remaining 38.4% refer to design methods. Searches were refined using Nvivo-10 software, and 101 documents were obtained about theoretical aspects while 17 focused on the application of methods, and these formed the analysis universe. The results show how little concern there is for working comprehensively on human and environmental aspects, and a trend toward segmentation of human and environmental aspects in the field of product/service design and development can be seen, at both concept and application/methodology levels. It was concluded from the above that comprehensive, simultaneous work is needed on human and environmental aspects, clarity and conceptual unity, in order to achieve sustainability in practical matters and ensure that ergoecology-compatible design methods are applied. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Fission product yields

    International Nuclear Information System (INIS)

    Valenta, V.; Hep, J.

    1978-01-01

    Data are summed up necessary for determining the yields of individual fission products from different fissionable nuclides. Fractional independent yields, cumulative and isobaric yields are presented here for the thermal fission of 235 U, 239 Pu, 241 Pu and for fast fission (approximately 1 MeV) of 235 U, 238 U, 239 Pu, 241 Pu; these values are included into the 5th version of the YIELDS library, supplementing the BIBFP library. A comparison is made of experimental data and possible improvements of calculational methods are suggested. (author)

  18. Comprehensive Chemical Fingerprinting of High-Quality Cocoa at Early Stages of Processing: Effectiveness of Combined Untargeted and Targeted Approaches for Classification and Discrimination.

    Science.gov (United States)

    Magagna, Federico; Guglielmetti, Alessandro; Liberto, Erica; Reichenbach, Stephen E; Allegrucci, Elena; Gobino, Guido; Bicchi, Carlo; Cordero, Chiara

    2017-08-02

    This study investigates chemical information of volatile fractions of high-quality cocoa (Theobroma cacao L. Malvaceae) from different origins (Mexico, Ecuador, Venezuela, Columbia, Java, Trinidad, and Sao Tomè) produced for fine chocolate. This study explores the evolution of the entire pattern of volatiles in relation to cocoa processing (raw, roasted, steamed, and ground beans). Advanced chemical fingerprinting (e.g., combined untargeted and targeted fingerprinting) with comprehensive two-dimensional gas chromatography coupled with mass spectrometry allows advanced pattern recognition for classification, discrimination, and sensory-quality characterization. The entire data set is analyzed for 595 reliable two-dimensional peak regions, including 130 known analytes and 13 potent odorants. Multivariate analysis with unsupervised exploration (principal component analysis) and simple supervised discrimination methods (Fisher ratios and linear regression trees) reveal informative patterns of similarities and differences and identify characteristic compounds related to sample origin and manufacturing step.

  19. Connected Vehicle Pilot Deployment Program phase 1 : comprehensive deployment plan : New York City : volume 1 : technical application : part I : technical and management approach.

    Science.gov (United States)

    2016-08-01

    This document describes the Deployment Plan for the New York City Department of Transportation (NYC) Connected Vehicle Pilot Deployment (CVPD) Project. This plan describes the approach to complete Phase 2 Design/Build/Test, and Phase 3 Operate and Ma...

  20. The Graduate Pedagogical Process in the Comprehensive General Medicine Specialization: towards a Practice based on the Cultural-historical Approach to Human Development

    OpenAIRE

    Ana Teresa Fernández Vidal; José Aurelio Díaz Quiñones; Silvia Enrique Vilaplana

    2016-01-01

    Cuban educators conceive programs and processes using the cultural-historical approach to human development, since this is the theory that, thanks to its founder Lev Semiónovich Vygotsky, could overcome the approaches that fragmented the analysis and understanding of the human development. Such currents of thought hyperbolized the different conditioning factors of this development and ignored the dialectical relationship between them in terms of personality formation and development, its proc...

  1. Compreensão textual em alunos de segunda e terceira séries: uma abordagem cognitiva Text comprehension in second and third graders: a cognitive approach

    Directory of Open Access Journals (Sweden)

    Jerusa Fumagalli de Salles

    2004-04-01

    Full Text Available Este estudo teve como objetivo analisar a compreensão de leitura textual de alunos de 2ª e 3ª séries. Participaram 76 crianças, com média de idade de 8,1 anos. Cada criança lia a história, recontava-a e, posteriormente, respondia a questões. Os recontos foram analisados segundo o Modelo de Compreensão Textual de Kintsch & van Dijk (1978 e Kintsch (1988, 1998. A amostra relatou, em média, 21,07% da estrutura proposicional da história, sendo mais freqüente o relato de macroproposições. Alunos da terceira série foram superiores aos da segunda série no relato de microproposições menos relevantes do texto e em responder a questões pontuais sobre a história. Foi encontrada uma correlação significativa entre idade e o reconto da macroestrutura textual. Os resultados sugerem que durante os primeiros anos de escolarização ocorreu uma melhora da memorização de detalhes, enquanto que a retenção das idéias essenciais foi influenciada pelas variações de idade das crianças.This study aimed to analyze text comprehension of students of the 2nd and 3rd grades. The sample was constituted by 76 children, at an average of 8.1 years old. Each child read the story, retold it and, afterwards, answered questions about it. The retellings were analyzed according to the model of Text Comprehension of Kintsch and van Dijk (1978 and Kintsch (1988, 1998. The sample recalled a mean of 21.07% of the proposition structure of the story, being the report of macropropositions more frequent. Students of the third grade told larger percentage of irrelevant micropropositions of the text and they were superior in answering to specific questions than students of the second grade. A significant correlation was found between age and macroproposition's retelling. The results suggest that during the first years of schooling there is an improvement of the detail-remembering, whereas the retention of the essential ideas is influenced by age differences.

  2. Yield surface evolution for columnar ice

    Science.gov (United States)

    Zhou, Zhiwei; Ma, Wei; Zhang, Shujuan; Mu, Yanhu; Zhao, Shunpin; Li, Guoyu

    A series of triaxial compression tests, which has capable of measuring the volumetric strain of the sample, were conducted on columnar ice. A new testing approach of probing the experimental yield surface was performed from a single sample in order to investigate yield and hardening behaviors of the columnar ice under complex stress states. Based on the characteristic of the volumetric strain, a new method of defined the multiaxial yield strengths of the columnar ice is proposed. The experimental yield surface remains elliptical shape in the stress space of effective stress versus mean stress. The effect of temperature, loading rate and loading path in the initial yield surface and deformation properties of the columnar ice were also studied. Subsequent yield surfaces of the columnar ice have been explored by using uniaxial and hydrostatic paths. The evolution of the subsequent yield surface exhibits significant path-dependent characteristics. The multiaxial hardening law of the columnar ice was established experimentally. A phenomenological yield criterion was presented for multiaxial yield and hardening behaviors of the columnar ice. The comparisons between the theoretical and measured results indicate that this current model is capable of giving a reasonable prediction for the multiaxial yield and post-yield properties of the columnar ice subjected to different temperature, loading rate and path conditions.

  3. Developing a programmatic approach to investigating and remediating many unrelated comprehensive environmental response, compensation, and liability act sites at Kelly Air Force Base

    International Nuclear Information System (INIS)

    Kamp, G.; Regan, P.; Ninesteel, R.; Martin, R.

    1988-01-01

    Kelly Air Force Base (AFB), which was founded in 1917, is involved in logistics and maintenance activities supporting the Air Logistics Command. In addition, Kelly AFB hosts over 50 tenant organizations representing the Air Force, Department of Defense, and other government agencies. Over the years waste disposal from this complex was conducted in a manner that led to the identification of over 30 sites to be included in the Installation Restoration Program (IRP) after the Phase 1 investigation. A methodology was needed to prioritize the Remedial Investigations and Feasibility Study (RI/FS) activities for the sites. A Strategy Plan was developed that involved reviewing and interpreting existing data, identifying data voids relative to site specific RI/FS activities, and developing methodology to prioritize activities. Sites were prioritized, and a comprehensive IRP planning document was developed. One data deficiency was revealed -- the lack of understanding of the Basewide hydrogeologic conditions necessary to establish an effective restoration program. A Hydrogeologic Investigation was initiated to provide this data. This data will allow better interpretation of the interaction of the sites, particularly those in close proximity, and improved planning of remediation activities

  4. The influences of skin visco-elasticity, hydration level and aging on the formation of wrinkles: a comprehensive and objective approach.

    Science.gov (United States)

    Choi, Jae Woo; Kwon, Soon Hyo; Huh, Chang Hun; Park, Kyoung Chan; Youn, Sang Woong

    2013-02-01

    Various skin parameters including skin visco-elasticity and hydration level affect the formation of wrinkles. The aim of this study was to investigate the comprehensive and objective relationship between age, skin visco-elasticity, hydration level, and the occurrence of wrinkles using bioengineering equipments for the first time. A total number of 97 healthy women were included in this study. Age, Fitzpatrick skin type, skin mechanical parameters obtained with Cutometer(R0~R9), hydration level measured with Corneometer, as well as wrinkle parameters (SEsm, SEr, SEsc, and SEw) assessed with Visioscan, were analyzed with the Pearson's correlation test. The skin fluidity (R6) increased while the elastic recovery ratio (R7) decreased with the age. The wrinkle parameter (SEw) also increased with the age. The higher skin hysteresis values (R4 and R9) coincided with the higher SEw values. Skin hydration significantly lowered the hysteresis (R9), the wrinkles (SEw), and the depth of wrinkle furrows (R3mr). The elderly have less elastic skin and more wrinkles. Skin hysteresis most closely related with the degree of wrinkles. Drier skin showed more wrinkles and deeper furrows, with wider intervals. On the basis of these objective findings, we propose several skin parameters associated with wrinkles, and hypothesize the mechanism of wrinkle generation. © 2012 John Wiley & Sons A/S.

  5. Soviet test yields

    Science.gov (United States)

    Vergino, Eileen S.

    Soviet seismologists have published descriptions of 96 nuclear explosions conducted from 1961 through 1972 at the Semipalatinsk test site, in Kazakhstan, central Asia [Bocharov et al., 1989]. With the exception of releasing news about some of their peaceful nuclear explosions (PNEs) the Soviets have never before published such a body of information.To estimate the seismic yield of a nuclear explosion it is necessary to obtain a calibrated magnitude-yield relationship based on events with known yields and with a consistent set of seismic magnitudes. U.S. estimation of Soviet test yields has been done through application of relationships to the Soviet sites based on the U.S. experience at the Nevada Test Site (NTS), making some correction for differences due to attenuation and near-source coupling of seismic waves.

  6. The effect of font size on reading comprehension on second and fifth grade children: bigger is not always better.

    Directory of Open Access Journals (Sweden)

    Tami Katzir

    Full Text Available Research on reading development has focused on the linguistic, cognitive, and recently, metacognitive skills children must master in order to learn to read. Less focus has been devoted to how the text itself, namely the perceptual features of the words, affects children's learning and comprehension. In this study, we manipulated perceptual properties of text by presenting reading passages in different font sizes, line lengths, and line spacing to 100 children in the second and fifth grades. For second graders (Experiment 1, decreasing font size, as well as increasing line length, yielded significantly lower comprehension scores. Line spacing had no effect on performance. For fifth graders (Experiment 2, decreasing font size yielded higher comprehension scores, yet there were no effects for line length and line spacing. Results are discussed within a "desirable difficulty" approach to reading development.

  7. Psychodermatology: A comprehensive review

    Directory of Open Access Journals (Sweden)

    Savita Yadav

    2013-01-01

    Full Text Available Psychodermatology is an interesting domain of dermatology that overlaps with psychiatry. This arena in dermatology has received limited diligence, partly due to lack of training in this realm. We present here a comprehensive review of salient features and treatment updates in primary psychiatric dermatoses and have also discussed the role of psyche in psychophysiological cutaneous disorders. Secondary psychiatric morbidity is relatively common among patients visiting the dermatologists but often overlooked and uncared for. Dermatologist should be able to initiate basic pharmacotherapy, should be knowledgeable about various non-pharmacological treatments and know the right time to refer the patient to the psychiatrist. Awareness and pertinent treatment of psychodermatological disorders among dermatologists will lead to a more holistic treatment approach and better prognosis in this unique group of patients.

  8. The potential of a human rights approach for accelerating the implementation of comprehensive restrictions on the marketing of unhealthy foods and non-alcoholic beverages to children.

    Science.gov (United States)

    Granheim, Sabrina Ionata; Vandevijvere, Stefanie; Torheim, Liv Elin

    2018-01-05

    Overweight and obesity in children is rising at the global level, particularly in low- and middle-income countries. Among the causes for this increase is the marketing of unhealthy food and beverage products, which affects children's food preferences, purchasing requests and consumption patterns. The need to address harmful marketing to children has been recognized at the World Health Organization, with Member States having agreed in 2010 to implement a set of recommendations to restrict such practices. Concurrently, there is an increasing understanding of unhealthy food and malnutrition as human rights concerns. This paper explores the potential of existing legally and non-legally binding human rights instruments for accelerating the implementation of comprehensive restrictions to reduce harmful marketing of unhealthy foods and beverages to children. Four relevant themes were identified in existing human rights instruments: (i) the best interest of the child should be considered above all other interests; (ii) the rights to health and adequate food cannot be realized without supportive healthy environments; (iii) children should be protected from economic exploitation; and (iv) the persuasive marketing of unhealthy food and beverage products is explicitly recognized as a threat to the rights to food and health. In conclusion, existing human rights instruments could be harnessed to advance public health measures to restrict the marketing of unhealthy food and beverage products to children. Policy-makers and advocates should draw from these instruments and refer to State's obligations within international and domestic human rights law to strengthen their efforts to restrict harmful marketing practices to children. © The Author(s) 2018. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  9. A comprehensive small and pilot-scale fixed-bed reactor approach for testing Fischer–Tropsch catalyst activity and performance on a BTL route

    Directory of Open Access Journals (Sweden)

    Piyapong Hunpinyo

    2017-05-01

    Full Text Available Ruthenium (Ru-based catalysts were prepared by the sol–gel technique for biomass-to-liquid (BTL operation and had their performance tested under different conditions. The catalytic study was carried out in two steps using a simple and reliable method. In the first step, the effects of reaction temperatures and inlet H2/CO molar feed ratios obtained from biomass gasification were investigated on the catalyst performance. A set of experimental results obtained in a laboratory fixed bed reactor was described and summarized. Moreover, a simplified Langmuir–Hinshelwood–Hougen–Watson (LHHW kinetic model was proposed with two promising models, where the surface decomposition of carbon monoxide was assumed as the rate determining step (RDS. In the second step, a FT pilot plant was conducted to validate the catalyst performance, especially the conversion efficiency, heat and mass transfer effects, and system controllability. The results indicated that our catalyst performances under mild conditions were not significantly different in many regards from those previously reported for a severe condition, as especially Ru-based catalyst can be performed to vary over a wide range of conditions to yield specific liquid productivity. The results in terms of the hydrocarbon product distribution obtained from the pilot scale operations were similar with that obtained from the related lab scale experiments.

  10. Language, culture and approaches to studying: towards a more comprehensive 3P Model; a cross-cultural study of the 3P Model in university students

    OpenAIRE

    Thong, Matthew Keen Shui

    2017-01-01

    Background: Language and culture are constructs that are difficult to quantify and measure; moreover, their effects on the process of learning and academic achievement can be difficult to determine. This thesis examined their effects using the theoretical framework of the Presage-Process-Product (3P) Model. The 3P Model allows the effects of various ‘presage’ factors on the ‘product’ of academic achievement to be mediated by the ‘process’ of approaches to learning. Aims: This thesis aime...

  11. Comprehensive metabolic panel

    Science.gov (United States)

    Metabolic panel - comprehensive; Chem-20; SMA20; Sequential multi-channel analysis with computer-20; SMAC20; Metabolic panel 20 ... Chernecky CC, Berger BJ. Comprehensive metabolic panel (CMP) - blood. In: ... Tests and Diagnostic Procedures . 6th ed. St Louis, MO: ...

  12. Nursing supervision for care comprehensiveness

    Directory of Open Access Journals (Sweden)

    Lucieli Dias Pedreschi Chaves

    Full Text Available ABSTRACT Objective: To reflect on nursing supervision as a management tool for care comprehensiveness by nurses, considering its potential and limits in the current scenario. Method: A reflective study based on discourse about nursing supervision, presenting theoretical and practical concepts and approaches. Results: Limits on the exercise of supervision are related to the organization of healthcare services based on the functional and clinical model of care, in addition to possible gaps in the nurse training process and work overload. Regarding the potential, researchers emphasize that supervision is a tool for coordinating care and management actions, which may favor care comprehensiveness, and stimulate positive attitudes toward cooperation and contribution within teams, co-responsibility, and educational development at work. Final considerations: Nursing supervision may help enhance care comprehensiveness by implying continuous reflection on including the dynamics of the healthcare work process and user needs in care networks.

  13. Non-invasive prenatal diagnosis of achondroplasia and thanatophoric dysplasia: next-generation sequencing allows for a safer, more accurate, and comprehensive approach.

    Science.gov (United States)

    Chitty, Lyn S; Mason, Sarah; Barrett, Angela N; McKay, Fiona; Lench, Nicholas; Daley, Rebecca; Jenkins, Lucy A

    2015-07-01

    Accurate prenatal diagnosis of genetic conditions can be challenging and usually requires invasive testing. Here, we demonstrate the potential of next-generation sequencing (NGS) for the analysis of cell-free DNA in maternal blood to transform prenatal diagnosis of monogenic disorders. Analysis of cell-free DNA using a PCR and restriction enzyme digest (PCR-RED) was compared with a novel NGS assay in pregnancies at risk of achondroplasia and thanatophoric dysplasia. PCR-RED was performed in 72 cases and was correct in 88.6%, inconclusive in 7% with one false negative. NGS was performed in 47 cases and was accurate in 96.2% with no inconclusives. Both approaches were used in 27 cases, with NGS giving the correct result in the two cases inconclusive with PCR-RED. NGS provides an accurate, flexible approach to non-invasive prenatal diagnosis of de novo and paternally inherited mutations. It is more sensitive than PCR-RED and is ideal when screening a gene with multiple potential pathogenic mutations. These findings highlight the value of NGS in the development of non-invasive prenatal diagnosis for other monogenic disorders. © 2015 John Wiley & Sons, Ltd.

  14. Enhancement of HHG yield

    International Nuclear Information System (INIS)

    Serrat, C.; Biegert, J.

    2011-01-01

    A static electric field periodically distributed in space controls and enhances the yield in high harmonic generation. The method is relatively simple to implement and allows tuning from the extreme-ultraviolet to soft X-ray. The radiation yield is selectively enhanced due to symmetry breaking induced by a static electric field on the interaction between the driving laser and the medium. The enhanced spectral region is tuned by varying the periodicity of the static electric field. Simulations predict an increase of more than two orders of magnitude for harmonics in the water window spectral range.

  15. Collaborative action for person-centred coordinated care (P3C): an approach to support the development of a comprehensive system-wide solution to fragmented care.

    Science.gov (United States)

    Lloyd, Helen M; Pearson, Mark; Sheaff, Rod; Asthana, Sheena; Wheat, Hannah; Sugavanam, Thava Priya; Britten, Nicky; Valderas, Jose; Bainbridge, Michael; Witts, Louise; Westlake, Debra; Horrell, Jane; Byng, Richard

    2017-11-22

    Fragmented care results in poor outcomes for individuals with complexity of need. Person-centred coordinated care (P3C) is perceived to be a potential solution, but an absence of accessible evidence and the lack of a scalable 'blue print' mean that services are 'experimenting' with new models of care with little guidance and support. This paper presents an approach to the implementation of P3C using collaborative action, providing examples of early developments across this programme of work, the core aim of which is to accelerate the spread and adoption of P3C in United Kingdom primary care settings. Two centrally funded United Kingdom organisations (South West Collaboration for Leadership in Applied Health Research and Care and South West Academic Health Science Network) are leading this initiative to narrow the gap between research and practice in this urgent area of improvement through a programme of service change, evaluation and research. Multi-stakeholder engagement and co-design are core to the approach. A whole system measurement framework combines outcomes of importance to patients, practitioners and health organisations. Iterative and multi-level feedback helps to shape service change while collecting practice-based data to generate implementation knowledge for the delivery of P3C. The role of the research team is proving vital to support informed change and challenge organisational practice. The bidirectional flow of knowledge and evidence relies on the transitional positioning of researchers and research organisations. Extensive engagement and embedded researchers have led to strong collaborations across the region. Practice is beginning to show signs of change and data flow and exchange is taking place. However, working in this way is not without its challenges; progress has been slow in the development of a linked data set to allow us to assess impact innovations from a cost perspective. Trust is vital, takes time to establish and is dependent on the

  16. The prehistoric mines of Gavà: an example of a comprehensive approach to the study and public presentation of an archaeological site

    Directory of Open Access Journals (Sweden)

    Blasco, Mònica

    2000-12-01

    Full Text Available The Prehistoric Mines of Gavà used to provide variscite about 6000 years ago. This mineral was used for decorative purposes! For the last ten years, the Gavà Museum has been implementing a comprehensive intervention (research, conservation and information dissemination campaign for the mines. This programme is financed by many different institutions, such as the city hall, the Generalitat de Cataluña (the Catalan Government, the Diputación de Barcelona (the city council and lNEM (employment office. The museum leads and coordinates an interdisciplinary team and has established cooperation agreements with some universities. The Prehistoric Mines can be visited since 1993, and meet the visitors´ safety, mobility and understanding requirements, without affecting their conservation and scientific rigor Visits are guided and their goal is to make people experience emotions. Although they have got a varied target group, they are especially aimed at students. Thus, there is a number of activities planned only for them. The visits to the Prehistoric Mines have been considered an accepted educational resource in Barcelona and its metropolitan area. The main future project of the museum is the Archaeological Park of the Prehistoric Mines. It will be a centre aimed at interpreting the Neolithic period and the origin of the mining industry. Its objectives are to maintain intervention and to attract the cultural tourism in Barcelona.

    Las Minas Prehistóricas de Gavá proporcionaron variscita, un material ornamental, hace 6000 años. Desde hace diez años el Museo de Gavá impulsa una intervención integral (investigación, conservación y difusión, financiada por diversas instituciones (Ayuntamiento, Generalitat de Cataluña, Diputación de Barcelona e INEM, lidera y coordina un equipo interdisciplinar y mantiene convenios de colaboración con diferentes universidades. Las minas están abiertas al público desde 1993 y

  17. Comprehensive approach to functional palatomaxillary reconstruction using regional and free tissue transfer: Report of reconstructive and prosthodontic outcomes of 140 patients.

    Science.gov (United States)

    Urken, Mark L; Roche, Ansley M; Kiplagat, Kimberly J; Dewey, Eliza H; Lazarus, Cathy; Likhterov, Ilya; Buchbinder, Daniel; Okay, Devin J

    2018-03-14

    Palatomaxillary defects were historically restored with a prosthetic obturator; however, advances in local and free tissue transfer has provided a viable alternative for appropriately selected patients with palatomaxillary defects. A retrospective chart review of patients who underwent palatomaxillary reconstruction by the lead author between 1998 and 2016 was conducted. Patients who were restored with a palatal obturator were excluded. One hundred forty patients were reconstructed with a total of 159 local, regional, and free flaps with a 96.7% success rate. Seventy-four patients (52.8%) underwent prosthodontic rehabilitation, with 183 implants placed and an 86% success rate. Palatomaxillary reconstruction applying a systematic approach, using a multitude of techniques, is a safe and effective way to restore patients without compromising the ability to maintain surveillance. Prosthodontic rehabilitation can be achieved in a high percentage of patients using dental implants, leading to optimal aesthetic and functional results. © 2018 Wiley Periodicals, Inc.

  18. Self-Active Relaxation Therapy (SART) and Self-Regulation: A Comprehensive Review and Comparison of the Japanese Body Movement Approach

    Science.gov (United States)

    Kabir, Russell S.; Haramaki, Yutaka; Ki, Hyeyoung; Ohno, Hiroyuki

    2018-01-01

    Relaxation programs are known for their versatility, cost-effectiveness, and ability to help people obtain skills to regulate their mental states and promote and maintain health. Self-Active Relaxation Therapy (SART) is a body-oriented approach to psychological rehabilitation that grew out of the suite of movement tasks developed in the Japanese psychotherapy known as Dohsa-hou, or the body movement method. The program for SART is designed to stretch, twist, and release areas of the upper, lower, and whole body through a set of movements which are guided by the practitioner and performed “self-actively” by the client to empower them to learn to recognize points of tension in the body and act on their own to achieve a relaxed state. Numerous studies have showed that SART is associated with reduced negative mood states and enhanced body awareness. A short version of SART has been investigated as a psychological support salon activity for the elderly, mothers raising children, special needs students, and children adapting to school. The full program has also been applied in clinical settings to address or supplement treatments for psychological and developmental conditions, and longitudinally employed in community contexts to assist residents facing long-term disaster recovery circumstances in Japan. This paper reviews the research and applications of SART as a bodymind approach by critically examining evidence and research gaps for future studies, comparing it with techniques established in the literature, and positing a self-regulatory framework for SART as a tool to become aware of bodily states, regulate mood, and manage stress through the deliberate practice of relaxation. PMID:29472851

  19. The Iowa K-12 Climate Science Education Initiative: a comprehensive approach to meeting in-service teachers' stated needs for teaching climate literacy with NGSS

    Science.gov (United States)

    Stanier, C. O.; Spak, S.; Neal, T. A.; Herder, S.; Malek, A.; Miller, Z.

    2017-12-01

    The Iowa Board of Education voted unanimously in 2015 to adopt NGSS performance standards. The CGRER - College of Education Iowa K-12 Climate Science Education Initiative was established in 2016 to work directly with Iowa inservice teachers to provide what teachers need most to teach climate literacy and climate science content through investigational learning aligned with NGSS. Here we present teachers' requests for teaching climate with NGSS, and an approach to provide resources for place-based authentic inquiry on climate, developed, tested, and refined in partnership with inservice and preservice teachers. A survey of inservice middle school and high school science teachers was conducted at the 2016 Iowa Council of Teachers of Mathematics/Iowa Academy of Sciences - Iowa Science Teaching Section Fall Conference and online in fall 2016. Participants (n=383) were asked about their prior experience and education, the resources they use and need, their level of comfort in teaching climate science, perceived barriers, and how they address potential controversy. Teachers indicated preference for professional development on climate content and complete curricula packaged with lessons and interactive models aligned to Iowa standards, as well as training on instructional strategies to enhance students' ability to interpret scientific evidence. We identify trends in responses by teaching experience, climate content knowledge and its source, grade level, and urban and rural districts. Less than 20% of respondents reported controversy or negativity in teaching climate to date, and a majority were comfortable teaching climate science and climate change, with equal confidence in teaching climate and other STEM content through investigational activities. We present an approach and materials to meet these stated needs, created and tested in collaboration with Iowa teachers. We combine professional development and modular curricula with bundled standards, concepts, models, data

  20. Self and External Monitoring of Reading Comprehension

    Science.gov (United States)

    Shiu, Ling-po; Chen, Qishan

    2013-01-01

    The present study compared the effectiveness of 2 approaches to remedy the inaccuracy of self-monitoring of reading comprehension. The first approach attempts to enhance self-monitoring by strengthening the cues utilized in monitoring. The second approach replaces self-monitoring with external regulation based on objective evaluative information.…

  1. What good is legislation--or planning--if we can't make it work? The need for a comprehensive approach to health and welfare.

    Science.gov (United States)

    Snoke, A W

    1982-09-01

    Health and welfare programs continue to be developed and implemented on a piecemeal basis in this country. There is difficulty in recognizing not only that health and social affairs are intimately related, but that the system must be dealt with as a whole of its interrelated problems are to be solved. Increasing costs for health and social programs are becoming of even greater concern, and cost containment (voluntary or regulatory) preoccupies both the payers and the recipients. Complicating the current situation is uncertainty of the role of financing and regulation on the part of the federal government and the states (the New Federalism), and the fragmentation and uncertainty of the private delivery sector and its third party reimbursement agencies. Questions are raised as to whether viable solutions can be obtained until all components (governmental and private) can work together in a partnership rather than an adversarial relationship in the development of an overall strategy with understandable objectives. Of basic importance is consideration of matters of organization, administration, and leadership at all levels so that whatever program may be developed or evolved can be successfully implemented. The subject is of such magnitude and is so complicated that it deserves a major coordinated effort of the federal government, the state governments, and the diverse private sector components to ensure a coordinated and systematic approach to any realistic solution.

  2. The California State University Louis Stokes Alliance for Minority Participation (CSU-LSAMP): A Collaborative, Comprehensive Approach to Broadening Participation in STEM.

    Science.gov (United States)

    Hammersley, L. C.

    2016-12-01

    The National Science Foundation's Louis Stokes Alliances for Minority Participation (LSAMP) program supports alliances of institutions in their efforts to broaden participation in STEM and diversify the STEM workforce. There are currently 42 LSAMP alliances across the nation. Formed in 1993, the California State University LSAMP program (CSU-LSAMP) is an alliance of all 23 campuses of the CSU system and serves over 3,000 students per year. The primary goals of CSU-LSAMP are to increase persistence and graduation rates for URM participants, increase the number of STEM degrees awarded by the CSU to URM students, and increase the number of CSU-LSAMP students who advance to STEM graduate study. CSU-LSAMP activities are focused on four objectives - academic support (e.g. supplemental instruction & peer mentoring), support at transition points (e.g. first time freshmen & transfer students), research experiences (including international research experiences), and professional development (e.g. conference presentations & graduate school preparation activities). Financial support is offered in the form of textbook assistance, research stipends, and travel awards. We maintain a structure that allows campuses to tailor their programs to meet the needs of their own student populations but that also ties the Alliance together with a set of common activities, goals and policies. External evaluation of the program shows that our approach has been highly successful and can provide useful lessons for other programs focused on broadening participation. Since 1994, the number of URM students enrolled in STEM disciplines at CSU campuses has more than doubled and the number of STEM degrees to URM students has almost tripled. Persistence and graduation rates for URM students who participate in CSU-LSAMP are almost twice those of URM non-participants and equal to those of non-URM students. Of the students who participated in the past 15 years, 42 percent either earned a post

  3. Influences of nitrogen and potassium top dressing on yield and yield ...

    African Journals Online (AJOL)

    STORAGESEVER

    2010-05-03

    May 3, 2010 ... (K) top dressing on grain yield and yield components of rice (Oryza sativa cv. Tarrom) and to ... positive reciprocal effect on crops, and was an important approach in ..... dressing fertilization (Figures 2a, b and c), but nitrogen levels of upper fully .... (Brassica napus L.)–rice (Oryza sativa L.) rotation. Plant Soil ...

  4. The European FP7 ULTimateCO2 project: A comprehensive approach to study the long term fate of CO2 geological storage sites

    Science.gov (United States)

    Audigane, P.; Brown, S.; Dimier, A.; Pearce, J.; Frykman, P.; Maurand, N.; Le Gallo, Y.; Spiers, C. J.; Cremer, H.; Rutters, H.; Yalamas, T.

    2013-12-01

    The European FP7 ULTimateCO2 project aims at significantly advance our knowledge of specific processes that could influence the long-term fate of geologically stored CO2: i) trapping mechanisms, ii) fluid-rock interactions and effects on mechanical integrity of fractured caprock and faulted systems and iii) leakage due to mechanical and chemical damage in the well vicinity, iv) brine displacement and fluid mixing at regional scale. A realistic framework is ensured through collaboration with two demonstration sites in deep saline sandstone formations: the onshore former NER300 West Lorraine candidate in France (ArcelorMittal GeoLorraine) and the offshore EEPR Don Valley (former Hatfield) site in UK operated by National Grid. Static earth models have been generated at reservoir and basin scale to evaluate both trapping mechanisms and fluid displacement at short (injection) and long (post injection) time scales. Geochemical trapping and reservoir behaviour is addressed through experimental approaches using sandstone core materials in batch reactive mode with CO2 and impurities at reservoir pressure and temperature conditions and through geochemical simulations. Collection of data has been generated from natural and industrial (oil industry) analogues on the fluid flow and mechanical properties, structure, and mineralogy of faults and fractures that could affect the long-term storage capacity of underground CO2 storage sites. Three inter-related lines of laboratory experiments investigate the long-term evolution of the mechanical properties and sealing integrity of fractured and faulted caprocks using Opalinus clay of Mont Terri Gallery (Switzerland) (OPA), an analogue for caprock well investigated in the past for nuclear waste disposal purpose: - Characterization of elastic parameters in intact samples by measuring strain during an axial experiment, - A recording of hydraulic fracture flow properties by loading and shearing samples in order to create a 'realistic

  5. Brazilian Soybean Yields and Yield Gaps Vary with Farm Size

    Science.gov (United States)

    Jeffries, G. R.; Cohn, A.; Griffin, T. S.; Bragança, A.

    2017-12-01

    Understanding the farm size-specific characteristics of crop yields and yield gaps may help to improve yields by enabling better targeting of technical assistance and agricultural development programs. Linking remote sensing-based yield estimates with property boundaries provides a novel view of the relationship between farm size and yield structure (yield magnitude, gaps, and stability over time). A growing literature documents variations in yield gaps, but largely ignores the role of farm size as a factor shaping yield structure. Research on the inverse farm size-productivity relationship (IR) theory - that small farms are more productive than large ones all else equal - has documented that yield magnitude may vary by farm size, but has not considered other yield structure characteristics. We examined farm size - yield structure relationships for soybeans in Brazil for years 2001-2015. Using out-of-sample soybean yield predictions from a statistical model, we documented 1) gaps between the 95th percentile of attained yields and mean yields within counties and individual fields, and 2) yield stability defined as the standard deviation of time-detrended yields at given locations. We found a direct relationship between soy yields and farm size at the national level, while the strength and the sign of the relationship varied by region. Soybean yield gaps were found to be inversely related to farm size metrics, even when yields were only compared to farms of similar size. The relationship between farm size and yield stability was nonlinear, with mid-sized farms having the most stable yields. The work suggests that farm size is an important factor in understanding yield structure and that opportunities for improving soy yields in Brazil are greatest among smaller farms.

  6. A comprehensive review of HIV/STI prevention and sexual and reproductive health services among sex Workers in Conflict-Affected Settings: call for an evidence- and rights-based approach in the humanitarian response.

    Science.gov (United States)

    Ferguson, Alyssa; Shannon, Kate; Butler, Jennifer; Goldenberg, Shira M

    2017-01-01

    While the conditions in emergency humanitarian and conflict-affected settings often result in significant sex work economies, there is limited information on the social and structural conditions of sex work in these settings, and the impacts on HIV/STI prevention and access to sexual and reproductive health (SRH) services for sex workers. Our objective was to comprehensively review existing evidence on HIV/STI prevention and access to SRH services for sex workers in conflict-affected settings globally. We conducted a comprehensive review of all peer review (both epidemiological and qualitative) and grey literature published in the last 15 years (2000-2015), focusing on 1) HIV/STI vulnerability or prevention, and/or 2) access to SRH services for sex workers in conflict-affected settings. Five databases were searched, using combinations of sex work, conflict/mobility, HIV/STI, and SRH service terms. Relevant peer-reviewed and grey literature were also hand-searched, and key papers were cross-referenced for additional material. Five hundred fifty one records were screened and 416 records reviewed. Of 33 records describing HIV/STI prevention and/or access to SRH services among sex workers in conflict-affected settings, 24 were from sub-Saharan Africa; 18 studies described the results of primary research (13 quantitative, 3 qualitative, 2 mixed-methods) and 15 were non-primary research (e.g., commentaries, policy reports, programmatic manuals). Available evidence indicated that within conflict-affected settings, SWs' capacity to engage in HIV/STI prevention and access SRH services is severely undermined by social and structural determinants including widespread violence and human rights violations, the collapse of livelihoods and traditional social structures, high levels of displacement, and difficulties accessing already scant health services due to stigma, discrimination and criminalization. This review identified significant gaps in HIV/STI and SRH research, policy

  7. The 2001 Comprehensive Review

    CERN Multimedia

    Åkesson, T

    A new approach for CERN to monitor the LHC-experiments' technical and scientific progress was introduced last year: The Comprehensive Reviews. A significant fraction of the full LHCC committee is mobilized during two days to review the complete project status. This event took place for ATLAS during 2-3 of July this year. With a rather exhaustive program we presented our status in 39 talks. It was a demanding and close to impossible task for the referees to comprehend the ATLAS status by listening to this massive amount of information, but from the ATLAS point-of-view we judged it important that the referees were exposed to both the progress and the remaining problem areas. The referees were satisfied with our status; probably more so this year than last year. They judged the main critical issues to be: The schedules of the barrel toroid, the end-cap TRT, the LAr barrel and end-cap A, and the MDTs. The procurement of radiation hard electronics was also thought to be a critical issue. They were informed of ...

  8. Simulating potential growth and yield of oil palm with PALMSIM

    NARCIS (Netherlands)

    Hoffmann, M.P.; Vera, A.C.; Wijk, van M.T.; Giller, K.E.; Oberthur, R.; Donough, C.; Whitbread, A.M.; Fisher, M.J.

    2014-01-01

    The growing demand for palm oil can be met by reducing the gap between potential yield and actual yield. Simulation models can quantify potential yield, and therefore indicate the scope for intensification. A relatively simple physiological approach was used to develop PALMSIM, which is a model that

  9. Status of fission yield measurements

    International Nuclear Information System (INIS)

    Maeck, W.J.

    1979-01-01

    Fission yield measurement and yield compilation activities in the major laboratories of the world are reviewed. In addition to a general review of the effort of each laboratory, a brief summary of yield measurement activities by fissioning nuclide is presented. A new fast reactor fission yield measurement program being conducted in the US is described

  10. Case in Language Comprehension

    NARCIS (Netherlands)

    Bader, Markus; Lamers, Monique

    2012-01-01

    Research on human language comprehension has been heavily influenced by properties of the English language. Since case plays only a minor role in English, its role for language comprehension has only recently become a topic for extensive research on psycholinguistics. In the psycholinguistic

  11. Spectrum of Physics Comprehension

    Science.gov (United States)

    Blasiak, W.; Godlewska, M.; Rosiek, R.; Wcislo, D.

    2012-01-01

    The paper presents the results of research on the relationship between self-assessed comprehension of physics lectures and final grades of junior high school students (aged 13-15), high school students (aged 16-18) and physics students at the Pedagogical University of Cracow, Poland (aged 21). Students' declared level of comprehension was measured…

  12. Probabilistic logic networks a comprehensive framework for uncertain inference

    CERN Document Server

    Goertzel, Ben; Goertzel, Izabela Freire; Heljakka, Ari

    2008-01-01

    This comprehensive book describes Probabilistic Logic Networks (PLN), a novel conceptual, mathematical and computational approach to uncertain inference. A broad scope of reasoning types are considered.

  13. Tactical nuclear studies: a more comprehensive approach

    International Nuclear Information System (INIS)

    Blumenthal, D.; Kooshian, C.; Reinhardt, G.; Staehle, G.

    1975-01-01

    A matrix scheme for evaluating complex tactical nuclear systems is proposed. Advantages resulting from consideration of system characteristics in peace and crisis as well as war include avoidance of scenario-dependent conclusions, ease of maintaining awareness of relationships between immediate concerns and the complex whole, and highlighting of areas or concerns that have been overlooked or neglected

  14. Comprehensive Approach Training Toolkit: Training Needs Analysis

    Science.gov (United States)

    2013-03-01

    general. t necessarily lea to act). Very litt Yoruba . entations liarization (FAM ology Integratio es. Content is p given cultural g nd pertinent lan...and focus-g training the C cially other g ncrease its th ng with CA c cation and re e cultural aw needs to con ; and g) traini g schedules a s are...milita tifs, de cultur olton, Febbra t, 2013; Thom es FC dans l’ la formation borer une boî alisée chez n ons se sont d ir compte dan é à clarifier l

  15. A comprehensive philosophical approach to Qohelet's epistemology

    African Journals Online (AJOL)

    2015-04-23

    Apr 23, 2015 ... limited space of a journal article as opposed to, say, a monograph. .... business that is done on earth, how neither day nor night ..... Hume, D., 1751, An enquiry concerning human understanding, Hackett, Indianapolis. Imray, K.

  16. Software defined networks a comprehensive approach

    CERN Document Server

    Goransson, Paul

    2014-01-01

    Software Defined Networks discusses the historical networking environment that gave rise to SDN, as well as the latest advances in SDN technology. The book gives you the state of the art knowledge needed for successful deployment of an SDN, including: How to explain to the non-technical business decision makers in your organization the potential benefits, as well as the risks, in shifting parts of a network to the SDN modelHow to make intelligent decisions about when to integrate SDN technologies in a networkHow to decide if your organization should be developing its own SDN applications or

  17. A comprehensive approach to assess operational resilience

    NARCIS (Netherlands)

    Stolker, R.J.M.; Karydas, D.M.; Rouvroye, J.L.; Hollnagel, E.; Pieri, F.

    2008-01-01

    This paper presents a first attempt to apply Multi-Attribute Utility Theory (MAUT) to the concept of resilience. The focus of this paper is measuring the management performance of operational resilience in an organization. Operational resilience refers to the ability of an organization to prevent

  18. Chemical Facility Preparedness: A Comprehensive Approach

    National Research Council Canada - National Science Library

    Pennington, Daniel

    2006-01-01

    .... Many sites are clustered together in densely populated areas. If terrorists cause catastrophic chemical releases or explosions at these key facilities, large numbers of Americans will be put at risk of injury or death...

  19. Increasing Influenza Vaccine Uptake. A Comprehensive Approach

    NARCIS (Netherlands)

    Looijmans - van den Akker, I.

    2009-01-01

    General introduction: To prevent influenza virus infection, immunization against influenza has been recommended for individuals with increased risk of complications. These groups comprise individuals of 60 years and older, individuals with risk-elevating co-morbid conditions, residents of nursing

  20. A Comprehensive Approach to Combating Illicit Trafficking

    Science.gov (United States)

    2010-06-01

    based in terms of production and sale. For example, ac- cording to the 2007 UN World Drug Re- port, drugs such as marijuana , which can be produced...and/or trafficking of heroin, cocaine, and synthetic drugs and precursors� • Crimes against Persons Unit (SC3)—Its main roles and responsibilities are...support, and coordinate law enforcement investigations; and identify links between different investigations in the area of synthetic drugs and precursors

  1. Comprehensive approach to the child with gastrostomy

    Directory of Open Access Journals (Sweden)

    Erika Šmid

    2013-10-01

    Full Text Available Endoscopic gastrostomy tube placement is the method of choice for enteral feeding of adults and children. It is most commonly needed in children with neurological impairment, and in those with swallowing difficulties. Complications are relatively common but in most cases not severe. Among the most common complications are bacterial and fungal infections of the skin around the tube.In adults, it is usually performed with local anesthesia, whereas in children general anesthesia is recommended.During the child’s hospitalization, parents are usually present in order to learn how to take care of the child at home. We offer them theoretical and practical knowledge about the life of a child with gastrostomy. We provide them information on feeding, skin care, possible complications, and actively include them in all steps of the process of gastrostomy nursing care as soon as possible.Likewise adults, children also have to be treated as equals, andfor this reason we have to know how to communicate with them, with special attention on child’s non-verbal communication. Nursing care to the child often presents an unfamiliar and even undesirable situation. It is therefore the role of the nurse to mitigate it by appropriate communication.It takes four to five days for parents to obtain sufficient information to be able to take care of their child at home. Upon discharge, they receive written information on percutaneous gastrostomy care.

  2. Working Memory Intervention: A Reading Comprehension Approach

    Science.gov (United States)

    Perry, Tracy L.; Malaia, Evguenia

    2013-01-01

    For any complex mental task, people rely on working memory. Working memory capacity (WMC) is one predictor of success in learning. Historically, attempts to improve verbal WM through training have not been effective. This study provided elementary students with WM consolidation efficiency training to answer the question, Can reading comprehension…

  3. Crop diversity for yield increase.

    Directory of Open Access Journals (Sweden)

    Chengyun Li

    2009-11-01

    Full Text Available Traditional farming practices suggest that cultivation of a mixture of crop species in the same field through temporal and spatial management may be advantageous in boosting yields and preventing disease, but evidence from large-scale field testing is limited. Increasing crop diversity through intercropping addresses the problem of increasing land utilization and crop productivity. In collaboration with farmers and extension personnel, we tested intercropping of tobacco, maize, sugarcane, potato, wheat and broad bean--either by relay cropping or by mixing crop species based on differences in their heights, and practiced these patterns on 15,302 hectares in ten counties in Yunnan Province, China. The results of observation plots within these areas showed that some combinations increased crop yields for the same season between 33.2 and 84.7% and reached a land equivalent ratio (LER of between 1.31 and 1.84. This approach can be easily applied in developing countries, which is crucial in face of dwindling arable land and increasing food demand.

  4. Quotient-Comprehension Chains

    Directory of Open Access Journals (Sweden)

    Kenta Cho

    2015-11-01

    Full Text Available Quotients and comprehension are fundamental mathematical constructions that can be described via adjunctions in categorical logic. This paper reveals that quotients and comprehension are related to measurement, not only in quantum logic, but also in probabilistic and classical logic. This relation is presented by a long series of examples, some of them easy, and some also highly non-trivial (esp. for von Neumann algebras. We have not yet identified a unifying theory. Nevertheless, the paper contributes towards such a theory by introducing the new quotient-and-comprehension perspective on measurement instruments, and by describing the examples on which such a theory should be built.

  5. Comprehensive cardiac rehabilitation

    DEFF Research Database (Denmark)

    Kruse, Marie; Hochstrasser, Stefan; Zwisler, Ann-Dorthe O

    2006-01-01

    OBJECTIVES: The costs of comprehensive cardiac rehabilitation are established and compared to the corresponding costs of usual care. The effect on health-related quality of life is analyzed. METHODS: An unprecedented and very detailed cost assessment was carried out, as no guidelines existed...... and may be as high as euro 1.877. CONCLUSIONS: Comprehensive cardiac rehabilitation is more costly than usual care, and the higher costs are not outweighed by a quality of life gain. Comprehensive cardiac rehabilitation is, therefore, not cost-effective....

  6. Smart Strategy to Boost Students' Reading Comprehension

    OpenAIRE

    Sfafi'i, Muhammad Lukman

    2015-01-01

    Reading as one of language skills plays significant roles in the teaching English as a foreign language. Since the teacher still uses the conventional way to teach reading, students‘ ability in reading comprehension seems still unsatisfactory yet. So, teacher should explore and develop new strategies. One of strategies in reading comprehension that can trigger our students to attain that purpose is SMART (Self Monitoring Approach for Reading and Thinking) strategy. ...

  7. Benefits of seasonal forecasts of crop yields

    Science.gov (United States)

    Sakurai, G.; Okada, M.; Nishimori, M.; Yokozawa, M.

    2017-12-01

    Major factors behind recent fluctuations in food prices include increased biofuel production and oil price fluctuations. In addition, several extreme climate events that reduced worldwide food production coincided with upward spikes in food prices. The stabilization of crop yields is one of the most important tasks to stabilize food prices and thereby enhance food security. Recent development of technologies related to crop modeling and seasonal weather forecasting has made it possible to forecast future crop yields for maize and soybean. However, the effective use of these technologies remains limited. Here we present the potential benefits of seasonal crop-yield forecasts on a global scale for choice of planting day. For this purpose, we used a model (PRYSBI-2) that can well replicate past crop yields both for maize and soybean. This model system uses a Bayesian statistical approach to estimate the parameters of a basic process-based model of crop growth. The spatial variability of model parameters was considered by estimating the posterior distribution of the parameters from historical yield data by using the Markov-chain Monte Carlo (MCMC) method with a resolution of 1.125° × 1.125°. The posterior distributions of model parameters were estimated for each spatial grid with 30 000 MCMC steps of 10 chains each. By using this model and the estimated parameter distributions, we were able to estimate not only crop yield but also levels of associated uncertainty. We found that the global average crop yield increased about 30% as the result of the optimal selection of planting day and that the seasonal forecast of crop yield had a large benefit in and near the eastern part of Brazil and India for maize and the northern area of China for soybean. In these countries, the effects of El Niño and Indian Ocean dipole are large. The results highlight the importance of developing a system to forecast global crop yields.

  8. Effect of Integrated Nutrient Management on Yield and Yield ...

    African Journals Online (AJOL)

    Declining soil fertility is one of the major problems causing yield reduction of barley ... (VC) with inorganic NP on growth, yield and yield components of food barley. ... The experiments were laid out in a randomized complete block design with ...

  9. Comprehensive geriatric assessment

    African Journals Online (AJOL)

    2007-09-14

    Sep 14, 2007 ... i.e. difficulty performing simple physical and mental tasks necessary for daily life. ... Definition. Comprehensive geriatric assessment (CGA) is a multidimensional .... The formation of a programme of therapy is decided on.

  10. Spectrum of physics comprehension

    International Nuclear Information System (INIS)

    Blasiak, W; Godlewska, M; Rosiek, R; Wcislo, D

    2012-01-01

    The paper presents the results of research on the relationship between self-assessed comprehension of physics lectures and final grades of junior high school students (aged 13-15), high school students (aged 16-18) and physics students at the Pedagogical University of Cracow, Poland (aged 21). Students' declared level of comprehension was measured during a physics lecture on a prearranged scale of 1-10 with the use of a personal response system designed for the purpose of this experiment. Through the use of this tool, we obtained about 2000 computer records of students' declared comprehension of a 45 min lecture, which we named ‘the spectrum of comprehension’. In this paper, we present and analyse the correlation between students' declared comprehension of the content presented in the lecture and their final learning results. (paper)

  11. A note on hypoplastic yielding

    OpenAIRE

    Nader, José Jorge

    2010-01-01

    This note discusses briefly the definition of yield surface in hypoplasticity in connection with the physical notion of yielding. The relation of yielding with the vanishing of the material time derivative of the stress tensor and the vanishing of the corotational stress rate is investigated.

  12. Water limits to closing yield gaps

    Science.gov (United States)

    Davis, Kyle Frankel; Rulli, Maria Cristina; Garrassino, Francesco; Chiarelli, Davide; Seveso, Antonio; D'Odorico, Paolo

    2017-01-01

    Agricultural intensification is often seen as a suitable approach to meet the growing demand for agricultural products and improve food security. It typically entails the use of fertilizers, new cultivars, irrigation, and other modern technology. In regions of the world affected by seasonal or chronic water scarcity, yield gap closure is strongly dependent on irrigation (blue water). Global yield gap assessments have often ignored whether the water required to close the yield gap is locally available. Here we perform a gridded global analysis (10 km resolution) of the blue water consumption that is needed annually to close the yield gap worldwide and evaluate the associated pressure on renewable freshwater resources. We find that, to close the yield gap, human appropriation of freshwater resources for irrigation would have to increase at least by 146%. Most study countries would experience at least a doubling in blue water requirement, with 71% of the additional blue water being required by only four crops - maize, rice, soybeans, and wheat. Further, in some countries (e.g., Algeria, Morocco, Syria, Tunisia, and Yemen) the total volume of blue water required for yield gap closure would exceed sustainable levels of freshwater consumption (i.e., 40% of total renewable surface and groundwater resources).

  13. Tile-based Fisher ratio analysis of comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC × GC-TOFMS) data using a null distribution approach.

    Science.gov (United States)

    Parsons, Brendon A; Marney, Luke C; Siegler, W Christopher; Hoggard, Jamin C; Wright, Bob W; Synovec, Robert E

    2015-04-07

    Comprehensive two-dimensional (2D) gas chromatography coupled with time-of-flight mass spectrometry (GC × GC-TOFMS) is a versatile instrumental platform capable of collecting highly informative, yet highly complex, chemical data for a variety of samples. Fisher-ratio (F-ratio) analysis applied to the supervised comparison of sample classes algorithmically reduces complex GC × GC-TOFMS data sets to find class distinguishing chemical features. F-ratio analysis, using a tile-based algorithm, significantly reduces the adverse effects of chromatographic misalignment and spurious covariance of the detected signal, enhancing the discovery of true positives while simultaneously reducing the likelihood of detecting false positives. Herein, we report a study using tile-based F-ratio analysis whereby four non-native analytes were spiked into diesel fuel at several concentrations ranging from 0 to 100 ppm. Spike level comparisons were performed in two regimes: comparing the spiked samples to the nonspiked fuel matrix and to each other at relative concentration factors of two. Redundant hits were algorithmically removed by refocusing the tiled results onto the original high resolution pixel level data. To objectively limit the tile-based F-ratio results to only features which are statistically likely to be true positives, we developed a combinatorial technique using null class comparisons, called null distribution analysis, by which we determined a statistically defensible F-ratio cutoff for the analysis of the hit list. After applying null distribution analysis, spiked analytes were reliably discovered at ∼1 to ∼10 ppm (∼5 to ∼50 pg using a 200:1 split), depending upon the degree of mass spectral selectivity and 2D chromatographic resolution, with minimal occurrence of false positives. To place the relevance of this work among other methods in this field, results are compared to those for pixel and peak table-based approaches.

  14. Dichotic listening performance predicts language comprehension.

    Science.gov (United States)

    Asbjørnsen, Arve E; Helland, Turid

    2006-05-01

    Dichotic listening performance is considered a reliable and valid procedure for the assessment of language lateralisation in the brain. However, the documentation of a relationship between language functions and dichotic listening performance is sparse, although it is accepted that dichotic listening measures language perception. In particular, language comprehension should show close correspondence to perception of language stimuli. In the present study, we tested samples of reading-impaired and normally achieving children between 10 and 13 years of age with tests of reading skills, language comprehension, and dichotic listening to consonant-vowel (CV) syllables. A high correlation between the language scores and the dichotic listening performance was expected. However, since the left ear score is believed to be an error when assessing language laterality, covariation was expected for the right ear scores only. In addition, directing attention to one ear input was believed to reduce the influence of random factors, and thus show a more concise estimate of left hemisphere language capacity. Thus, a stronger correlation between language comprehension skills and the dichotic listening performance when attending to the right ear was expected. The analyses yielded a positive correlation between the right ear score in DL and language comprehension, an effect that was stronger when attending to the right ear. The present results confirm the assumption that dichotic listening with CV syllables measures an aspect of language perception and language skills that is related to general language comprehension.

  15. THE NATURE OF COMPREHENSION.

    Science.gov (United States)

    CLELAND, DONALD L.

    THE NATURE OF COMPREHENSION IS DEFINED AND CLARIFIED. THE LITERATURE IS SURVEYED TO SHOW THAT THE DEVELOPMENT OF CONCEPTS IS IMPORTANT IN INTELLECTUAL ACTIVITIES. IT IS POINTED OUT THAT CONCEPTS ARE BUILT FROM PERCEPTS, IMAGES, SENSATION, AND MEMORIES, AND THAT THE STEPS WHICH ARE EMPLOYED AS CONCEPTS ARE BUILT AND REFINED AND INCLUDE PERCEIVING,…

  16. Painless reading comprehension

    CERN Document Server

    Jones, EdD, Darolyn "Lyn"

    2016-01-01

    Reading comprehension gets easier as students learn what kind of reader they are, discover how to keep facts in their head, and much more. Bonus Online Component: includes additional games, including Beat the Clock, a line match game, and a word scramble.

  17. Comprehensive Environmental Management Process

    International Nuclear Information System (INIS)

    Hjeresen, D.L.; Roybal, S.L.

    1994-01-01

    This report contains information about Los Alamos National Laboratory's Comprehensive Environmental Management Plan. The topics covered include: waste minimization, waste generation, environmental concerns, public relations of the laboratory, and how this plan will help to answer to the demands of the laboratory as their mission changes

  18. A comprehensive psychiatric service

    DEFF Research Database (Denmark)

    Wang, A G

    1984-01-01

    A comprehensive psychiatric service was established in 1969 in the Faroe Islands. This service was created as a department of a general hospital. The spheres covered by this department, operating in the midst of the community were: acute and chronic patients, a liaison-psychiatric service...

  19. Systematics in delayed neutron yields

    Energy Technology Data Exchange (ETDEWEB)

    Ohsawa, Takaaki [Kinki Univ., Higashi-Osaka, Osaka (Japan). Atomic Energy Research Inst.

    1998-03-01

    An attempt was made to reproduce the systematic trend observed in the delayed neutron yields for actinides on the basis of the five-Gaussian representation of the fission yield together with available data sets for delayed neutron emission probability. It was found that systematic decrease in DNY for heavier actinides is mainly due to decrease of fission yields of precursors in the lighter side of the light fragment region. (author)

  20. VARIABILITY OF YIELD AND YIELD COMPONENTS IN “EGUSI ...

    African Journals Online (AJOL)

    journal

    Estimate of expected genetic advance in seed yield plant-1 ranged between. 25.90-48.40%. ..... values in fruit and seed yield characters have been reported in culinary melon, ... and Khund, A. 2004. Extent of heterosis and heritability in some.

  1. Response of Yield and Yield Components of Tef [Eragrostis Tef ...

    African Journals Online (AJOL)

    The partial budget analysis also indicates that applications of 46 kg. N ha-1 and 10 kg P ha-1 are ..... (1994) indicated that where the grain yield response is negative, yield reduction is primarily caused by a .... An Economic Training. Manual.

  2. On yield gaps and yield gains in intercropping

    NARCIS (Netherlands)

    Gou, Fang; Yin, Wen; Hong, Yu; Werf, van der Wopke; Chai, Qiang; Heerink, Nico; Ittersum, van Martin K.

    2017-01-01

    Wheat-maize relay intercropping has been widely used by farmers in northwest China, and based on field experiments agronomists report it has a higher productivity than sole crops. However, the yields from farmers’ fields have not been investigated yet. Yield gap analysis provides a framework to

  3. 7755 EFFECT OF NPK FERTILIZER ON FRUIT YIELD AND YIELD ...

    African Journals Online (AJOL)

    Win7Ent

    2013-06-03

    Jun 3, 2013 ... peasant farmers in Nigeria. With the increased ... did not significantly (p=0.05) increase the fruit yield nor the seed yield. Key words: NPK fertilizer, Fruit ..... SAS (Statistical Analysis System) Version 9.1. SAS Institute Inc., Cary, ...

  4. SLIFER measurement for explosive yield

    International Nuclear Information System (INIS)

    Bass, R.C.; Benjamin, B.C.; Miller, H.M.; Breding, D.R.

    1976-04-01

    This report describes the shorted location indicator by frequency of electrical resonance (SLIFER) system used at Sandia Laboratories for determination of explosive yield of under ground nuclear tests

  5. Cognitive Correlates of Listening Comprehension

    Science.gov (United States)

    Kim, Young-Suk; Phillips, Beth

    2014-01-01

    In an effort to understand cognitive foundations of oral language comprehension (i.e., listening comprehension), we examined how inhibitory control, theory of mind, and comprehension monitoring are uniquely related to listening comprehension over and above vocabulary and age. A total of 156 children in kindergarten and first grade from…

  6. Improvement of FK506 Production in the High-Yielding Strain Streptomyces sp. RM7011 by Engineering the Supply of Allylmalonyl-CoA Through a Combination of Genetic and Chemical Approach.

    Science.gov (United States)

    Mo, SangJoon; Lee, Sung-Kwon; Jin, Ying-Yu; Suh, Joo-Won

    2016-02-01

    FK506, a widely used immunosuppressant, is a 23-membered polyketide macrolide that is produced by several Streptomyces species. FK506 high-yielding strain Streptomyces sp. RM7011 was developed from the discovered Streptomyces sp. KCCM 11116P by random mutagenesis in our previous study. The results of transcript expression analysis showed that the transcription levels of tcsA, B, C, and D were increased in Streptomyces sp. RM7011 by 2.1-, 3.1-, 3.3-, and 4.1- fold, respectively, compared with Streptomyces sp. KCCM 11116P. The overexpression of tcsABCD genes in Streptomyces sp. RM7011 gave rise to approximately 2.5-fold (238.1 μg/ml) increase in the level of FK506 production compared with that of Streptomyces sp. RM7011. When vinyl pentanoate was added into the culture broth of Streptomyces sp. RM7011, the level of FK506 production was approximately 2.2-fold (207.7 μg/ml) higher than that of the unsupplemented fermentation. Furthermore, supplementing the culture broth of Streptomyces sp. RM7011 expressing tcsABCD genes with vinyl pentanoate resulted in an additional 1.7-fold improvement in the FK506 titer (498.1 μg/ml) compared with that observed under nonsupplemented condition. Overall, the level of FK506 production was increased approximately 5.2-fold by engineering the supply of allylmalonyl-CoA in the high-yielding strain Streptomyces sp. RM7011, using a combination of overexpressing tcsABCD genes and adding vinyl pentanoate, as compared with Streptomyces sp. RM7011 (95.3 μg/ml). Moreover, among the three precursors analyzed, pentanoate was the most effective precursor, supporting the highest titer of FK506 in the FK506 high-yielding strain Streptomyces sp. RM7011.

  7. The CSAICLAWPS project: a multi-scalar, multi-data source approach to providing climate services for both modelling of climate change impacts on crop yields and development of community-level adaptive capacity for sustainable food security

    Science.gov (United States)

    Forsythe, N. D.; Fowler, H. J.

    2017-12-01

    The "Climate-smart agriculture implementation through community-focused pursuit of land and water productivity in South Asia" (CSAICLAWPS) project is a research initiative funded by the (UK) Royal Society through its Challenge Grants programme which is part of the broader UK Global Challenges Research Fund (GCRF). CSAICLAWPS has three objectives: a) development of "added-value" - bias assessed, statistically down-scaled - climate projections for selected case study sites across South Asia; b) investigation of crop failure modes under both present (observed) and future (projected) conditions; and c) facilitation of developing local adaptive capacity and resilience through stakeholder engagement. At AGU we will be presenting both next steps and progress to date toward these three objectives: [A] We have carried out bias assessments of a substantial multi-model RCM ensemble (MME) from the CORDEX South Asia (CORDEXdomain for case studies in three countries - Pakistan, India and Sri Lanka - and (stochastically) produced synthetic time-series for these sites from local observations using a Python-based implementation of the principles underlying the Climate Research Unit Weather Generator (CRU-WG) in order to enable probabilistic simulation of current crop yields. [B] We have characterised present response of local crop yields to climate variability in key case study sites using AquaCrop simulations parameterised based on input (agronomic practices, soil conditions, etc) from smallholder farmers. [C] We have implemented community-based hydro-climatological monitoring in several case study "revenue villages" (panchayats) in the Nainital District of Uttarakhand. The purpose of this is not only to increase availability of meteorological data, but also has the aspiration of, over time, leading to enhanced quantitative awareness of present climate variability and potential future conditions (as projected by RCMs). Next steps in our work will include: 1) future crop yield

  8. Comprehensive Musicianship and Undergraduate Music Curricula.

    Science.gov (United States)

    Willoughby, David

    Comprehensive musicianship is a concept about teaching and learning music. It is an approach that suggests that the source of all musical study is the "literature" of music, and promotes the integration of all aspects of music study. This volume presents a synthesis of the philosophy and practice of 32 experimental programs based on the concept of…

  9. Comprehensive Family Services and Customer Satisfaction Outcomes

    Science.gov (United States)

    Huebner, Ruth A.; Jones, Blake L.; Miller, Viola P.; Custer, Melba; Critchfield, Becky

    2006-01-01

    Comprehensive Family Services (CFS) is a strengths-based and partnership-oriented approach to casework implemented through multiple initiatives. This study examines the relationship between the practice of CFS and satisfaction of clients, foster parents, and community partners. CFS indicators are paired with statewide customer satisfaction survey…

  10. Comprehensive Essays for World History Finals.

    Science.gov (United States)

    Feldman, Martha J.

    1997-01-01

    Describes a novel approach to comprehensive questions in world history examinations. Recommends using current events as illustrative reference points for complex subjects such as nationalism, liberalism, and international trade. Students receive information packets on the events for several weeks and must relate the subjects to these events. (MJP)

  11. Market reactions to the ECB's Comprehensive Assessment

    NARCIS (Netherlands)

    Sahin, Cenkhan; de Haan, Jakob

    Using an event study approach, we examine financial markets' reactions to the publication of the ECB's Comprehensive Assessment of banks in the euro area. Our results suggest that banks' stock market prices and CDS spreads generally showed no reaction. (C) 2015 Elsevier B.V. All rights reserved.

  12. Evaluating Dynamic Analysis Techniques for Program Comprehension

    NARCIS (Netherlands)

    Cornelissen, S.G.M.

    2009-01-01

    Program comprehension is an essential part of software development and software maintenance, as software must be sufficiently understood before it can be properly modified. One of the common approaches in getting to understand a program is the study of its execution, also known as dynamic analysis.

  13. Deep enteroscopy - indications, diagnostic yield and complications

    OpenAIRE

    Moeschler, Oliver; Mueller, Michael Karl

    2015-01-01

    Since its introduction in 2001 capsule endoscopy opened up the small bowel for diagnostic approaches followed by double balloon enteroscopy which enabled the endoscopic community to perform therapeutic interventions in the whole small intestine. In this review the scientific developments related to indications, diagnostic yield and complications of the last years between the competing devices double ballon enteroscopy, single balloon enteroscopy and spiral enteroscopy are illustrated.

  14. Using an integrated method to estimate watershed sediment yield during heavy rain period: a case study in Hualien County, Taiwan

    Directory of Open Access Journals (Sweden)

    S. M. Hsu

    2012-06-01

    Full Text Available A comprehensive approach estimating sediment yield from a watershed is needed to develop better measures for mitigating sediment disasters and assessing downstream impacts. In the present study, an attempt has been made to develop an integrated method, considering sediment supplies associated with soil erosion, shallow landslide and debris flow to estimate sediment yield from a debris-flow-prone watershed on a storm event basis. The integrated method is based on the HSPF and TRIGRS models for predicting soil erosion and shallow landslide sediment yield, and the FLO-2D model for calculating debris flow sediment yield. The proposed method was applied to potential debris-flow watersheds located in the Sioulin Township of Hualien County. The available data such as hourly rainfall data, historical streamflow and sediment records as well as event-based landslide inventory maps have been used for model calibration and validation. Results for simulating sediment yield have been confirmed by comparisons of observed data from several typhoon events. The verified method employed a 24-h design hyetograph with the 100-yr return period to simulate sediment yield within the study area. The results revealed that the influence of shallow landslides on sediment supply as compared with soil erosion was significant. The estimate of landslide transport capacity into a main channel indicated the sediment delivery ratio on a typhoon event basis was approximately 38.4%. In addition, a comparison of sediment yields computed from occurrence and non-occurrence of debris flow scenarios showed that the sediment yield from an occurrence condition was found to be increasing at about 14.2 times more than estimated under a non-occurrence condition. This implied watershed sediment hazard induced by debris flow may cause severe consequences.

  15. Nuclear energy and comprehension of the region

    International Nuclear Information System (INIS)

    Kim, Gyeong Dong; Hong, Du Seung

    1992-12-01

    This book explains the comprehension of nuclear energy with making approaches to social science. So it deals with disposal of radiation active waste as an social issue, recognition to nuclear energy of people and understanding of the region and support for the development of the region. It introduces two Anti-nuclear energy movements happened in Anmyondo and Yeongdeok. It reports these two cases approached with the method of social science.

  16. Breeding for Grass Seed Yield

    DEFF Research Database (Denmark)

    Boelt, Birte; Studer, Bruno

    2010-01-01

    Seed yield is a trait of major interest for many fodder and amenity grass species and has received increasing attention since seed multiplication is economically relevant for novel grass cultivars to compete in the commercial market. Although seed yield is a complex trait and affected...... by agricultural practices as well as environmental factors, traits related to seed production reveal considerable genetic variation, prerequisite for improvement by direct or indirect selection. This chapter first reports on the biological and physiological basics of the grass reproduction system, then highlights...... important aspects and components affecting the seed yield potential and the agronomic and environmental aspects affecting the utilization and realization of the seed yield potential. Finally, it discusses the potential of plant breeding to sustainably improve total seed yield in fodder and amenity grasses....

  17. Comprehensive hard materials

    CERN Document Server

    2014-01-01

    Comprehensive Hard Materials deals with the production, uses and properties of the carbides, nitrides and borides of these metals and those of titanium, as well as tools of ceramics, the superhard boron nitrides and diamond and related compounds. Articles include the technologies of powder production (including their precursor materials), milling, granulation, cold and hot compaction, sintering, hot isostatic pressing, hot-pressing, injection moulding, as well as on the coating technologies for refractory metals, hard metals and hard materials. The characterization, testing, quality assurance and applications are also covered. Comprehensive Hard Materials provides meaningful insights on materials at the leading edge of technology. It aids continued research and development of these materials and as such it is a critical information resource to academics and industry professionals facing the technological challenges of the future. Hard materials operate at the leading edge of technology, and continued res...

  18. interrelationships between grain yield and other physiological traits

    African Journals Online (AJOL)

    Prof. Adipala Ekwamu

    Combined analysis of variance, cluster analysis and genotype-by- ... all phenological and morphological traits, except grain yield and associated yield components. ... egg, and other protein-rich foods (Alghali, 1991). ... systematic modelling approach. ... MD IT98 K -132 – 3 .... traits based on Principal Component axes (PC)1.

  19. Fiber optic yield monitor for a sugarcane chopper harvester

    Science.gov (United States)

    A fiber optic yield monitoring system was developed for a sugarcane chopper harvester that utilizes a duty-cycle type approach with three fiber optic sensors mounted in the elevator floor to estimate cane yield. Field testing of the monitor demonstrated that there was a linear relationship between t...

  20. Multimodal imaging and detection approach to 18F-FDG-directed surgery for patients with known or suspected malignancies: a comprehensive description of the specific methodology utilized in a single-institution cumulative retrospective experience

    Directory of Open Access Journals (Sweden)

    Povoski Stephen P

    2011-11-01

    Full Text Available Abstract Background 18F-FDG PET/CT is widely utilized in the management of cancer patients. The aim of this paper was to comprehensively describe the specific methodology utilized in our single-institution cumulative retrospective experience with a multimodal imaging and detection approach to 18F-FDG-directed surgery for known/suspected malignancies. Methods From June 2005-June 2010, 145 patients were injected with 18F-FDG in anticipation of surgical exploration, biopsy, and possible resection of known/suspected malignancy. Each patient underwent one or more of the following: (1 same-day preoperative patient diagnostic PET/CT imaging, (2 intraoperative gamma probe assessment, (3 clinical PET/CT specimen scanning of whole surgically resected specimens (WSRS, research designated tissues (RDT, and/or sectioned research designated tissues (SRDT, (4 micro PET/CT specimen scanning of WSRS, RDT, and/or SRDT, (5 total radioactivity counting of each SRDT piece by an automatic gamma well counter, and (6 same-day postoperative patient diagnostic PET/CT imaging. Results Same-day 18F-FDG injection dose was 15.1 (± 3.5, 4.6-26.1 mCi. Fifty-five same-day preoperative patient diagnostic PET/CT scans were performed. One hundred forty-two patients were taken to surgery. Three of the same-day preoperative patient diagnostic PET/CT scans led to the cancellation of the anticipated surgical procedure. One hundred forty-one cases utilized intraoperative gamma probe assessment. Sixty-two same-day postoperative patient diagnostic PET/CT scans were performed. WSRS, RDT, and SRDT were scanned by clinical PET/CT imaging and micro PET/CT imaging in 109 and 32 cases, 33 and 22 cases, and 49 and 26 cases, respectively. Time from 18F-FDG injection to same-day preoperative patient diagnostic PET/CT scan, intraoperative gamma probe assessment, and same-day postoperative patient diagnostic PET/CT scan were 73 (± 9, 53-114, 286 (± 93, 176-532, and 516 (± 134, 178-853 minutes

  1. How reading comprehension is embodied and why that matters

    Directory of Open Access Journals (Sweden)

    Arthur M. GLENBERG

    2011-11-01

    Full Text Available Reading comprehension, much like comprehension of situations and comprehension of oral language, is embodied. In all cases, comprehension is the ability to take effective action on the basis ofaffordances related to the body, the physical world, and personal goals and cultural norms. In language contexts, action-based comprehension arises from simulating the linguistic content usingneural and bodily systems of perception, action, and emotion. Within this framework, a new approach to teaching reading comprehension is described: Teach children how to simulate while reading. TheMoved by Reading intervention teaches simulation in two stages. In the first stage, physical manipulation, children manipulate toys to simulate the content of what they are reading. After success in physically manipulating the toys, the children are taught to manipulate the toys in imagination. Research demonstrates that both physical and imagined manipulation leads to large gains in memory and comprehension.

  2. How reading comprehension is embodied and why that matters

    Directory of Open Access Journals (Sweden)

    Arthur M. Glenberg

    2011-10-01

    Full Text Available Reading comprehension, much like comprehension of situations and comprehension of oral language, is embodied. In all cases, comprehension is the ability to take effective action on the basis of affordances related to the body, the physical world, and personal goals and cultural norms. In language contexts, action-based comprehension arises from simulating the linguistic content using neural and bodily systems of perception, action, and emotion. Within this framework, a new approach to teaching reading comprehension is described: Teach children how to simulate while reading. The Moved by Reading intervention teaches simulation in two stages. In the first stage, physical manipulation, children manipulate toys to simulate the content of what they are reading. After success in physically manipulating the toys, the children are taught to manipulate the toys in imagination. Research demonstrates that both physical and imagined manipulation leads to large gains in memory and comprehension.

  3. Nitrogen rate and plant population effects on yield and yield ...

    African Journals Online (AJOL)

    STORAGESEVER

    2008-12-17

    Gan et al., 2003). Nitrogen increases yield by influencing a variety of agronomic and quality parameters. In general, there was an increase in plant height and dry matter accumulation per plant in soybean (Manral and Saxena, ...

  4. Nitrogen rate and plant population effects on yield and yield ...

    African Journals Online (AJOL)

    STORAGESEVER

    2008-12-17

    Dec 17, 2008 ... density and nitrogen rate increased plant height, lowest pod height, harvest index and seed yield. ... since some combine harvester heads are unable to pick ..... as effected by population density and plant distribution.

  5. Microencapsulation of β-Carotene Based on Casein/Guar Gum Blend Using Zeta Potential-Yield Stress Phenomenon: an Approach to Enhance Photo-stability and Retention of Functionality.

    Science.gov (United States)

    Thakur, Deepika; Jain, Ashay; Ghoshal, Gargi; Shivhare, U S; Katare, O P

    2017-07-01

    β-Carotene, abundant majorly in carrot, pink guava yams, spinach, kale, sweet potato, and palm oil, is an important nutrient for human health due to its scavenging action upon reactive free radicals wherever produced in the body. Inclusion of liposoluble β-carotene in foods and food ingredients is a challenging aspect due to its labile nature and low absorption from natural sources. This fact has led to the application of encapsulation of β-carotene to improve stability and bioavailability. The present work was aimed to fabricate microcapsules (MCs) of β-carotene oily dispersion using the complex coacervation technique with casein (CA) and guar gum (GG) blend. The ratio of CA:GG was found to be 1:0.5 (w/v) when optimized on the basis of zeta potential-yield stress phenomenon. These possessed a higher percentage yield (71.34 ± 0.55%), lower particle size (176.47 ± 4.65 μm), higher encapsulation efficiency (65.95 ± 5.33%), and in general, a uniform surface morphology was observed with particles showing optimized release behavior. Prepared MCs manifested effective and controlled release (up to 98%) following zero-order kinetics which was adequately explained by the Korseymer-Peppas model. The stability of the freeze-dried MCs was established in simulated gastrointestinal fluids (SGF, SIF) for 8 h. Antioxidant activity of the MCs was studied and revealed the retention of the functional architecture of β-carotene in freeze-dried MCs. Minimal photolytic degradation upon encapsulation of β-carotene addressed the challenge regarding photo-stability of β-carotene as confirmed via mass spectroscopy.

  6. Effects of application boron on yields, yield component and oil ...

    African Journals Online (AJOL)

    The study was conducted to investigate the effects of five boron (B) doses; 0, 2.5, 5.0, 7.5 and 10.0 kg B ha-1 in B-deficient calcareous soils on yield and some yield components of four sunflower genotypes. Genotypes have shown variations with respect to their responses to B applications. AS-615 and Coban had the ...

  7. Decomposing global crop yield variability

    Science.gov (United States)

    Ben-Ari, Tamara; Makowski, David

    2014-11-01

    Recent food crises have highlighted the need to better understand the between-year variability of agricultural production. Although increasing future production seems necessary, the globalization of commodity markets suggests that the food system would also benefit from enhanced supplies stability through a reduction in the year-to-year variability. Here, we develop an analytical expression decomposing global crop yield interannual variability into three informative components that quantify how evenly are croplands distributed in the world, the proportion of cultivated areas allocated to regions of above or below average variability and the covariation between yields in distinct world regions. This decomposition is used to identify drivers of interannual yield variations for four major crops (i.e., maize, rice, soybean and wheat) over the period 1961-2012. We show that maize production is fairly spread but marked by one prominent region with high levels of crop yield interannual variability (which encompasses the North American corn belt in the USA, and Canada). In contrast, global rice yields have a small variability because, although spatially concentrated, much of the production is located in regions of below-average variability (i.e., South, Eastern and South Eastern Asia). Because of these contrasted land use allocations, an even cultivated land distribution across regions would reduce global maize yield variance, but increase the variance of global yield rice. Intermediate results are obtained for soybean and wheat for which croplands are mainly located in regions with close-to-average variability. At the scale of large world regions, we find that covariances of regional yields have a negligible contribution to global yield variance. The proposed decomposition could be applied at any spatial and time scales, including the yearly time step. By addressing global crop production stability (or lack thereof) our results contribute to the understanding of a key

  8. Climate-induced yield variability and yield gaps of maize (Zea mays L.) in the Central Rift Valley of Ethiopia

    NARCIS (Netherlands)

    Kassie, B.T.; Ittersum, van M.K.; Hengsdijk, H.; Asseng, S.; Wolf, J.; Rotter, R.P.

    2014-01-01

    There is a high demand for quantitative information on impacts of climate on crop yields, yield gaps and their variability in Ethiopia, yet, quantitative studies that include an indication of uncertainties in the estimates are rare. A multi-model crop growth simulation approach using the two crop

  9. Spatio-temporal dynamics of maize yield water constraints under climate change in Spain.

    Science.gov (United States)

    Ferrero, Rosana; Lima, Mauricio; Gonzalez-Andujar, Jose Luis

    2014-01-01

    Many studies have analyzed the impact of climate change on crop productivity, but comparing the performance of water management systems has rarely been explored. Because water supply and crop demand in agro-systems may be affected by global climate change in shaping the spatial patterns of agricultural production, we should evaluate how and where irrigation practices are effective in mitigating climate change effects. Here we have constructed simple, general models, based on biological mechanisms and a theoretical framework, which could be useful in explaining and predicting crop productivity dynamics. We have studied maize in irrigated and rain-fed systems at a provincial scale, from 1996 to 2009 in Spain, one of the most prominent "hot-spots" in future climate change projections. Our new approach allowed us to: (1) evaluate new structural properties such as the stability of crop yield dynamics, (2) detect nonlinear responses to climate change (thresholds and discontinuities), challenging the usual linear way of thinking, and (3) examine spatial patterns of yield losses due to water constraints and identify clusters of provinces that have been negatively affected by warming. We have reduced the uncertainty associated with climate change impacts on maize productivity by improving the understanding of the relative contributions of individual factors and providing a better spatial comprehension of the key processes. We have identified water stress and water management systems as being key causes of the yield gap, and detected vulnerable regions where efforts in research and policy should be prioritized in order to increase maize productivity.

  10. Bulk yields of nucleosynthesis from massive stars

    International Nuclear Information System (INIS)

    Arnett, W.D.

    1978-01-01

    Preliminary estimates are made of the absolute yields of abundant nuclei synthesized in observed stars. The compositions of nine helium stars of mass 3 or =10M/sub sun/ is estimated. A variety of choices for the initial mass function (IMF) are used to calculate the yield per stellar generation. For standard choices of the (IMF) the absolute and relative yields of 12 C, 16 O, 20 Ne, 24 Mg, the Si to Ca group, and the iron group agree with solar system values, to the accuracy of the calculations. The relative yields are surprisingly insensitive to the slope of the IMF. In a second approach, using standard estimates (Ostriker, Richstone, and Thuan) for the current rate of stellar death, I find the present rate of nucleosynthesis in the solar neighborhood to be about 10%of the average rate over galactic history. This result is consistent with many standard models of galactic evolution (for example, the Schmidt model in which star formation goes as gas density squared). It appears that if the star formation rate is high enough to produce the stars we see around us, then the nucleosynthesis rate is large enough to produce the processed nuclei (except 4 He) seen in those stars. The typical nucleosynthesis source is massive (Mapprox. =30 M/sub sun/); the death rate of such stars is a small fraction (3-10%) of recent estimates of the total rate of supernovae

  11. Comparison of RS/GIS analysis with classic mapping approaches for siting low-yield boreholes for hand pumps in crystalline terrains. An application to rural communities of the Caimbambo province, Angola

    Science.gov (United States)

    Martín-Loeches, Miguel; Reyes-López, Jaime; Ramírez-Hernández, Jorge; Temiño-Vela, Javier; Martínez-Santos, Pedro

    2018-02-01

    In poverty-stricken regions of Sub-Saharan Africa, groundwater for supply is often obtained by means of hand pumps, which means that low-yield boreholes are acceptable. However, boreholes are often sited without sufficient hydrogeological information due to budget constraints, which leads to high failure rates. Cost-effective techniques for borehole siting need to be developed in order to maximize the success rate. In regions underlain by granite, weathered formations are usually targeted for drilling, as these are generally presented as a better cost-benefit ratio than the fractured basement. Within this context, this research focuses on a granite region of Angola. A comparison of two mapping techniques for borehole siting-groundwater prospect is presented. A classic hydrogeomorphological map was developed first based on aerial photographs, field mapping and a geophysical survey. This map represents a considerable time investment and was developed by qualified technicians. The second map (RS/GIS) is considerably simpler and more cost-effective. It was developed by the integration in a GIS platform of six maps of equal importance-slope, drainage density, vegetation vigor, presence of clay in the soil, lineaments and rock outcrops-prepared from Landsat 8 imagery and a Digital Elevation Model (DEM). Similar results were obtained in both cases. By means of a supervised classification of Landsat images, RS/GIS analysis allows for the identification of granitic outcrops, house clusters and sandy alluvial valleys. This in turn allows for the delineation of low-interest or contamination-prone areas, thus contributing additional qualitative information. The position of a well that is going to be powered by a handpump is chosen also upon social and local matters as the distance to the stakeholders, information that are not difficult to integrate in the GIS. Although the second map needs some field inputs (i.e. surveys to determine the thickness of the weathered pack

  12. Rice Research to Break Yield Barriers

    Science.gov (United States)

    Verma, Vivek; Ramamoorthy, Rengasamy; Kohli, Ajay; Kumar, Prakash P.

    2015-10-01

    The world’s population continues to expand and it is expected to cross 9 billion by 2050. This would significantly amplify the demand for food, which will pose serious threats to global food security. Additional challenges are being imposed due to a gradual decrease in the total arable land and global environmental changes. Hence, it is of utmost importance to review and revise the existing food production strategies by incorporating novel biotechnological approaches that can help to break the crop yield barriers in the near future. In this review, we highlight some of the concerns hampering crop yield enhancements. The review also focuses on modern breeding techniques based on genomics as well as proven biotechnological approaches that enable identification and utilization of candidate genes. Another aspect of discussion is the important area of research, namely hormonal regulation of plant development, which is likely to yield valuable regulatory genes for such crop improvement efforts in the future. These strategies can serve as potential tools for developing elite crop varieties for feeding the growing billions.

  13. A comprehensive French grammar

    CERN Document Server

    Price, Glanville

    2013-01-01

    Characterized by clear and accessible explanations, numerous examples and sample sentences, a new section on register and tone, and useful appendices covering topics including age and time, A Comprehensive French Grammar, Sixth Edition is an indispensable tool for advanced students of French language and literature.A revised edition of this established, bestselling French grammarIncludes a new section on register and medium and offers expanded treatment of French punctuationFeatures numerous examples and sample sentences, and useful appendices covering topics including age, time, and dimension

  14. Comprehensive multiplatform collaboration

    Science.gov (United States)

    Singh, Kundan; Wu, Xiaotao; Lennox, Jonathan; Schulzrinne, Henning G.

    2003-12-01

    We describe the architecture and implementation of our comprehensive multi-platform collaboration framework known as Columbia InterNet Extensible Multimedia Architecture (CINEMA). It provides a distributed architecture for collaboration using synchronous communications like multimedia conferencing, instant messaging, shared web-browsing, and asynchronous communications like discussion forums, shared files, voice and video mails. It allows seamless integration with various communication means like telephones, IP phones, web and electronic mail. In addition, it provides value-added services such as call handling based on location information and presence status. The paper discusses the media services needed for collaborative environment, the components provided by CINEMA and the interaction among those components.

  15. Fission yield measurements at IGISOL

    Science.gov (United States)

    Lantz, M.; Al-Adili, A.; Gorelov, D.; Jokinen, A.; Kolhinen, V. S.; Mattera, A.; Moore, I.; Penttilä, H.; Pomp, S.; Prokofiev, A. V.; Rakopoulos, V.; Rinta-Antila, S.; Simutkin, V.; Solders, A.

    2016-06-01

    The fission product yields are an important characteristic of the fission process. In fundamental physics, knowledge of the yield distributions is needed to better understand the fission process. For nuclear energy applications good knowledge of neutroninduced fission-product yields is important for the safe and efficient operation of nuclear power plants. With the Ion Guide Isotope Separator On-Line (IGISOL) technique, products of nuclear reactions are stopped in a buffer gas and then extracted and separated by mass. Thanks to the high resolving power of the JYFLTRAP Penning trap, at University of Jyväskylä, fission products can be isobarically separated, making it possible to measure relative independent fission yields. In some cases it is even possible to resolve isomeric states from the ground state, permitting measurements of isomeric yield ratios. So far the reactions U(p,f) and Th(p,f) have been studied using the IGISOL-JYFLTRAP facility. Recently, a neutron converter target has been developed utilizing the Be(p,xn) reaction. We here present the IGISOL-technique for fission yield measurements and some of the results from the measurements on proton induced fission. We also present the development of the neutron converter target, the characterization of the neutron field and the first tests with neutron-induced fission.

  16. Fission yield measurements at IGISOL

    Directory of Open Access Journals (Sweden)

    Lantz M.

    2016-01-01

    Full Text Available The fission product yields are an important characteristic of the fission process. In fundamental physics, knowledge of the yield distributions is needed to better understand the fission process. For nuclear energy applications good knowledge of neutroninduced fission-product yields is important for the safe and efficient operation of nuclear power plants. With the Ion Guide Isotope Separator On-Line (IGISOL technique, products of nuclear reactions are stopped in a buffer gas and then extracted and separated by mass. Thanks to the high resolving power of the JYFLTRAP Penning trap, at University of Jyväskylä, fission products can be isobarically separated, making it possible to measure relative independent fission yields. In some cases it is even possible to resolve isomeric states from the ground state, permitting measurements of isomeric yield ratios. So far the reactions U(p,f and Th(p,f have been studied using the IGISOL-JYFLTRAP facility. Recently, a neutron converter target has been developed utilizing the Be(p,xn reaction. We here present the IGISOL-technique for fission yield measurements and some of the results from the measurements on proton induced fission. We also present the development of the neutron converter target, the characterization of the neutron field and the first tests with neutron-induced fission.

  17. Training Comprehensiveness: Construct Development and Relation with Role Behaviour

    Science.gov (United States)

    Srivastava, Anugamini Priya; Dhar, Rajib Lochan

    2015-01-01

    Purpose: This study aims to develop the scale for perception of training comprehensiveness and attempts to examine the influence of perception of training comprehensiveness on role behaviour: teachers' efficacy as a mediator and job autonomy as a moderator. Design/methodology/approach: Through the steps for a generation, refinement, purification…

  18. Potential well yields from unconsolidated deposits in the lower Hudson and Delaware River basins, New York

    Science.gov (United States)

    Wolcott, Stephen W.

    1987-01-01

    A comprehensive groundwater protection plan, developed by the New York State Department of Environmental Conservation in 1985, identified the need to delineate significant aquifers within the state. A map of the unconsolidated aquifers in the lower Hudson and Delaware River basins was compiled from available data on the surficial geology and well yields. It delineates the significant unconsolidated aquifers and indicates the potential yield of wells that tap these aquifers. The potential well yield is categorized into three ranges: 100 gal/min. No yield range is given for till, but some large diameter or dug wells in till may yield up 10 gal/min. (Lantz-PTT)

  19. Plant-based assessment of inherent soil productivity and contributions to China's cereal crop yield increase since 1980.

    Directory of Open Access Journals (Sweden)

    Mingsheng Fan

    Full Text Available OBJECTIVE: China's food production has increased 6-fold during the past half-century, thanks to increased yields resulting from the management intensification, accomplished through greater inputs of fertilizer, water, new crop strains, and other Green Revolution's technologies. Yet, changes in underlying quality of soils and their effects on yield increase remain to be determined. Here, we provide a first attempt to quantify historical changes in inherent soil productivity and their contributions to the increase in yield. METHODS: The assessment was conducted based on data-set derived from 7410 on-farm trials, 8 long-term experiments and an inventory of soil organic matter concentrations of arable land. RESULTS: Results show that even without organic and inorganic fertilizer addition crop yield from on-farm trials conducted in the 2000s was significantly higher compared with those in the 1980s - the increase ranged from 0.73 to 1.76 Mg/ha for China's major irrigated cereal-based cropping systems. The increase in on-farm yield in control plot since 1980s was due primarily to the enhancement of soil-related factors, and reflected inherent soil productivity improvement. The latter led to higher and stable yield with adoption of improved management practices, and contributed 43% to the increase in yield for wheat and 22% for maize in the north China, and, 31%, 35% and 22% for early and late rice in south China and for single rice crop in the Yangtze River Basin since 1980. CONCLUSIONS: Thus, without an improvement in inherent soil productivity, the 'Agricultural Miracle in China' would not have happened. A comprehensive strategy of inherent soil productivity improvement in China, accomplished through combining engineering-based measures with biological-approaches, may be an important lesson for the developing world. We propose that advancing food security in 21st century for both China and other parts of world will depend on continuously improving

  20. Comprehensive overview of prostatitis.

    Science.gov (United States)

    Khan, Farhan Ullah; Ihsan, Awais Ullah; Khan, Hidayat Ullah; Jana, Ruby; Wazir, Junaid; Khongorzul, Puregmaa; Waqar, Muhammad; Zhou, Xiaohui

    2017-10-01

    Prostatitis is a common urinary tract syndrome that many doctors find problematic to treat effectively. It is the third most commonly found urinary tract disease in men after prostate cancer and Benign Prostate Hyperplasia (BPH). Prostatitis may account for 25% of all office visits made to the urological clinics complaining about the genital and urinary systems all over the world. In the present study, we classified prostatitis and comprehensively elaborated the etiology, pathogenesis, diagnosis, and treatment of acute bacterial prostatitis (category I), chronic bacterial prostatitis (category II), chronic pelvic pain syndrome (CPPS) (category III), and asymptomatic prostatitis (category IV). In addition, we also tried to get some insights about other types of prostatitis-like fungal, viral and gonococcal prostatitis. The aim of this review is to present the detail current perspective of prostatitis in a single review. To the best of our knowledge currently, there is not a single comprehensive review, which can completely elaborate this important topic in an effective way. Furthermore, this review will provide a solid platform to conduct future studies on different aspects such as risk factors, mechanism of pathogenesis, proper diagnosis, and rational treatment plans for fungal, viral, and gonococcal prostatitis. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  1. Comprehensive national energy strategy

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-04-01

    This Comprehensive National Energy Strategy sets forth a set of five common sense goals for national energy policy: (1) improve the efficiency of the energy system, (2) ensure against energy disruptions, (3) promote energy production and use in ways that respect health and environmental values, (4) expand future energy choices, and (5) cooperate internationally on global issues. These goals are further elaborated by a series of objectives and strategies to illustrate how the goals will be achieved. Taken together, the goals, objectives, and strategies form a blueprint for the specific programs, projects, initiatives, investments, and other actions that will be developed and undertaken by the Federal Government, with significant emphasis on the importance of the scientific and technological advancements that will allow implementation of this Comprehensive National Energy Strategy. Moreover, the statutory requirement of regular submissions of national energy policy plans ensures that this framework can be modified to reflect evolving conditions, such as better knowledge of our surroundings, changes in energy markets, and advances in technology. This Strategy, then, should be thought of as a living document. Finally, this plan benefited from the comments and suggestions of numerous individuals and organizations, both inside and outside of government. The Summary of Public Comments, located at the end of this document, describes the public participation process and summarizes the comments that were received. 8 figs.

  2. A Comprehensive Planning Model

    Science.gov (United States)

    Temkin, Sanford

    1972-01-01

    Combines elements of the problem solving approach inherent in methods of applied economics and operations research and the structural-functional analysis common in social science modeling to develop an approach for economic planning and resource allocation for schools and other public sector organizations. (Author)

  3. Strategy-based listening and pragmatic comprehension

    Directory of Open Access Journals (Sweden)

    Corsetti, Cristiane Ruzicki

    2014-01-01

    Full Text Available This article addresses the role of strategy-based listening as an alternative methodological approach to develop pragmatic comprehension in L2 contexts. Pragmatic comprehension refers to the understanding of speech acts and conversational implicatures. Listening comprehension comprises both bottom-up and top-down processes. Strategy-based listening encompasses the activation of pragmatic knowledge through pre-listening activities and the development of specific listening micro-skills. An empirical project which included a classroom project carried out with a group of eight learners preparing for the IELTS examination in 2009 corroborated the following assumptions: in order to achieve listening proficiency, learners need practice in making inferences as semantic and pragmatic inferences are embedded in verbal communication; semantic and pragmatic aspects affecting the meaning of utterances can be highlighted via comprehension activities focusing on specific listening subskills. The results of the classroom project suggested that strategy-based listening is potentially capable of directly enhancing pragmatic comprehension but were inconclusive with regards to pragmatic production

  4. Do comprehensive schools reduce social mobility?

    Science.gov (United States)

    Boliver, Vikki; Swift, Adam

    2011-03-01

    This paper investigates the claim that the shift from a selective to a comprehensive school system had a deleterious effect on social mobility in Great Britain. Using data from the National Child Development Study, we compare the chances, for both class and income mobility, of those who attended different kinds of school. Where media attention focuses exclusively on the chances for upward mobility of those children from lowly origins who were (or would have been) judged worthy of selection into a grammar school, we offer more rounded analyses. We match respondents in a way that helps us to distinguish those inequalities in mobility chances that are due to differences between children from those due to differences between the schools they attended; we look at the effects of the school system on the mobility chances of all children, not merely those from less advantaged origins; and we compare comprehensive- and selective-system schools, not merely comprehensive and grammar schools. After matching, we find, first, that going to a grammar school rather than a comprehensive does not make low-origin children more likely to be upwardly mobile but it helps them move further if they are; second, that grammar schools do not benefit working-class children, in terms of class mobility, more than they benefit service-class children, but, in terms of income mobility, such schools benefit low-income children somewhat more than they benefit higher-income children - that benefit relating only to rather modest and limited movements within the income distribution. Finally, however, the selective system as a whole yields no mobility advantage of any kind to children from any particular origins: any assistance to low-origin children provided by grammar schools is cancelled out by the hindrance suffered by those who attended secondary moderns. Overall, our findings suggest that comprehensive schools were as good for mobility as the selective schools they replaced. © London School of

  5. Comprehensive adaptive mesh refinement in wrinkling prediction analysis

    NARCIS (Netherlands)

    Selman, A.; Meinders, Vincent T.; Huetink, Han; van den Boogaard, Antonius H.

    2002-01-01

    Discretisation errors indicator, contact free wrinkling and wrinkling with contact indicators are, in a challenging task, brought together and used in a comprehensive approach to wrinkling prediction analysis in thin sheet metal forming processes.

  6. Nursing supervision for care comprehensiveness.

    Science.gov (United States)

    Chaves, Lucieli Dias Pedreschi; Mininel, Vivian Aline; Silva, Jaqueline Alcântara Marcelino da; Alves, Larissa Roberta; Silva, Maria Ferreira da; Camelo, Silvia Helena Henriques

    2017-01-01

    To reflect on nursing supervision as a management tool for care comprehensiveness by nurses, considering its potential and limits in the current scenario. A reflective study based on discourse about nursing supervision, presenting theoretical and practical concepts and approaches. Limits on the exercise of supervision are related to the organization of healthcare services based on the functional and clinical model of care, in addition to possible gaps in the nurse training process and work overload. Regarding the potential, researchers emphasize that supervision is a tool for coordinating care and management actions, which may favor care comprehensiveness, and stimulate positive attitudes toward cooperation and contribution within teams, co-responsibility, and educational development at work. Nursing supervision may help enhance care comprehensiveness by implying continuous reflection on including the dynamics of the healthcare work process and user needs in care networks. refletir a supervisão de enfermagem como instrumento gerencial do enfermeiro para integralidade do cuidado, considerando suas potencialidades e limitações no cenário atual. estudo reflexivo baseado na formulação discursiva sobre a supervisão de enfermagem, apresentando conceitos e enfoques teóricos e/ou práticos. limitações no exercício da supervisão estão relacionadas à organização dos serviços de saúde embasada no modelo funcional e clínico de atenção, assim como possíveis lacunas no processo de formação do enfermeiro e sobrecarga de trabalho. Quanto às potencialidades, destaca-se a supervisão como instrumento de articulação de ações assistenciais e gerenciais, que pode favorecer integralidade da atenção, estimular atitudes de cooperação e colaboração em equipe, além da corresponsabilização e promoção da educação no trabalho. supervisão de enfermagem pode contribuir para fortalecimento da integralidade do cuidado, pressupondo reflexão cont

  7. Evaluation of Yield and Yield Attributes of Five Sweet Potato ...

    African Journals Online (AJOL)

    0087, and TIS 2532.OP.1.13) were evaluated for yield and agronomic performance in Imo State University Farm, Owerri. The experiment was laid out in a randomised complete block design with three replications. The planting density was 33,000 ...

  8. Heterosis and combining ability for grain yield and yield component ...

    African Journals Online (AJOL)

    ... ranged from 0 to -13% indicating that the hybrids tend to be earlier in maturity than the parents. The mean squares due to GCA for days to maturity, ear diameter, member of kernels per row, 1000 kernel weight and grain yield were significant, indicating the importance of additive genetic variance in controlling these traits.

  9. Rice yield prediction from yield components and limiting factors

    NARCIS (Netherlands)

    Casanova, D.; Goudriaan, J.; Catala Former, M.M.; Withagen, J.C.M.

    2002-01-01

    This article aims to quantify growth at field level in relation to crop status and soil properties in irrigated direct-seeded rice. Forty fields were selected in the Ebro Delta (Spain). Rice growth was monitored and soil properties measured. Yield was related to soil properties by a deductive

  10. Correlation Analysis of some Growth, Yield, Yield Components and ...

    African Journals Online (AJOL)

    three critical growth stages which was imposed by withholding water (at ... November, 5th December, 19th December and 2nd January) laid out in a split ... Simple correlation coefficient ® of different crop parameters and grain yield ... The husk bran and germ are rich sources of ..... heat in 2009/2010 dry season at Fadam a ...

  11. Comprehensive Environmental Management Plan

    International Nuclear Information System (INIS)

    Hjeresen, D.L.

    1994-01-01

    The Environmental Management Program at Los Alamos National Laboratory is in the process of initiating and then implementing a Comprehensive Environmental Management Plan (CEMP). There are several environmental impact and compliance drivers for this initiative. The Los Alamos CEMP is intended to be a flexible, long-range process that predicts, minimizes, treats, and disposes of any waste generated in execution of the Los Alamos mission - even if that mission changes. The CEMP is also intended to improve stakeholder and private sector involvement and access to environmental information. The total quality environmental management (TQEM) process will benchmark Los Alamos to private sector and DOE operations, identify opportunities for improvement, prioritize among opportunities, implement projects, measure progress, and spur continuous improvement in Environmental Management operations

  12. Comprehensive nuclear materials

    CERN Document Server

    Allen, Todd; Stoller, Roger; Yamanaka, Shinsuke

    2012-01-01

    Comprehensive Nuclear Materials encapsulates a panorama of fundamental information on the vast variety of materials employed in the broad field of nuclear technology. The work addresses, in five volumes, 3,400 pages and over 120 chapter-length articles, the full panorama of historical and contemporary international research in nuclear materials, from Actinides to Zirconium alloys, from the worlds' leading scientists and engineers. It synthesizes the most pertinent research to support the selection, assessment, validation and engineering of materials in extreme nuclear environments. The work discusses the major classes of materials suitable for usage in nuclear fission, fusion reactors and high power accelerators, and for diverse functions in fuels, cladding, moderator and control materials, structural, functional, and waste materials.

  13. Status of fission yield data

    International Nuclear Information System (INIS)

    England, T.R.; Blachot, J.

    1988-01-01

    In this paper we summarize the current status of the recent US evaluation for 34 fissioning nuclides at one or more neutron incident energies and for spontaneous fission. Currently there are 50 yields sets, and for each we have independent and cumulative yields and uncertainties for approximately 1100 fission products. When finalized the recommended data will become part of Version VI of the US ENDF/B. Other major evaluations in progress that are included in a recently formed IAEA Coordinated Research Program are also summarized. In a second part we review two empirical models in use to estimate independent yields. Comparison of model estimates with measured data is presented, including a comparison with some recent data obtained from Lohengrin (Cf-249 T). 18 refs., 13 figs., 3 tabs

  14. Methane Yield Database: Online infrastructure and bioresource for methane yield data and related metadata.

    Science.gov (United States)

    Murovec, Boštjan; Kolbl, Sabina; Stres, Blaž

    2015-01-01

    The aim of this study was to develop and validate a community supported online infrastructure and bioresource for methane yield data and accompanying metadata collected from published literature. In total, 1164 entries described by 15,749 data points were assembled. Analysis of data collection showed little congruence in reporting of methodological approaches. The largest identifiable source of variation in reported methane yields was represented by authorship (i.e. substrate batches within particular substrate class) within which experimental scales (volumes (0.02-5l), incubation temperature (34-40 °C) and % VS of substrate played an important role (p 63%). This calls for reconsideration of accepted approaches to reporting data in currently published literature to increase capacity to service industrial decision making to a greater extent. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. Assessing potential sustainable wood yield

    Science.gov (United States)

    Robert F. Powers

    2001-01-01

    Society is making unprecedented demands on world forests to produce and sustain many values. Chief among them is wood supply, and concerns are rising globally about the ability of forests to meet increasing needs. Assessing this is not easy. It requires a basic understanding of the principles governing forest productivity: how wood yield varies with tree and stand...

  16. GENETIC ANALYSIS OF YIELD AND YIELD COMPONENTS IN ...

    African Journals Online (AJOL)

    ACSS

    2017-11-16

    Nov 16, 2017 ... used different genotypes and the environmental conditions under which their ... and Jinks (1971):. Y = m + aa + βd + a2aa + 2aβad +β2dd … .... /plant, 100-grain weight per plant and Grain yield per plant (g) of six generations in IET6279 X IR70445-146-3-. 3 cross. Traits. Generation. Mean. Standard. Range.

  17. Justice foundations for the Comprehensive Law Movement.

    Science.gov (United States)

    Dewhurst, Dale

    2010-01-01

    Authors examining the developing dispute resolution alternatives to the adversarial system have identified nine converging "vectors" or alternatives in what has been termed the Comprehensive Law Movement. These authors have sought to understand how the developing vectors can remain separate and vibrant movements while sharing common ground. Some analyze these developments as being within law and legal practice, others see them as alternative approaches to law, and still others take a combined approach. It will be impossible to understand how these vectors have meaningful differences from law and legal practice if the search is limited to looking within law and legal practice. It will be impossible to understand how these vectors have meaningful commonalities with law and legal practice if the search is limited to looking external to law and legal practice. Instead of comparing the vectors with the adversarial system, higher order criteria are required. What is needed is a comprehensive and internally consistent super-system of norms; one that can be used to evaluate the adversarial system and the evolving vectors on an equal footing. An Aristotelian natural law virtue theory of justice can: (a) provide a functional guiding definition of justice; (b) serve as a comprehensive and internally consistent super-system of norms; and (c) provide the theoretical and evaluative foundation required to clarify the relationships among the adversarial system and the developing vectors. Finally, it will become clear why the Comprehensive Law Movement might be more appropriately conceptualized as the Comprehensive Justice Movement. Copyright © 2010 Elsevier Ltd. All rights reserved.

  18. Reading Comprehension Strategies

    Directory of Open Access Journals (Sweden)

    Unal Ulker

    2017-12-01

    Full Text Available The academic success of the university students greatly depends on the mastery of an academic reading skill. However, students as well as teachers, take the learning of this skill for granted, as they tend to presuppose that reading skill is acquired as a part of their secondary education. As a result, most first-year students employ non university strategies to read academic texts, which leads to a surface approach to reading and prevents students from a better understanding of the material. This paper will discuss the strategies that involve students in taking a deep approach to reading academic texts.

  19. Potato yield and yield structure depending on irrigation

    Directory of Open Access Journals (Sweden)

    Milić Stanko

    2010-01-01

    Full Text Available In the agroclimatic conditions of the Vojvodina Province, the application of an economic water regime and modern technology is necessary for stable and intensive potato production. A two-year experiment on calcareous chernozem was carried out to determine how irrigation and different pre-irrigation soil moisture affect potato yield and distribution of tuber fraction in the potato yield. The block-design trial had four replicates and was adapted for sprinkler irrigation conditions. It included four treatments: irrigation with pre-irrigation moisture levels of 60 % of field water capacity (FC, irrigation with pre-irrigation moisture levels of 70 % (FC, irrigation with pre-irrigation moisture levels of 80% (FC, and a non-irrigated control treatment. Irrigation significantly increased the yield of potato, which increased from 37.27 % to 75.86 %. Under irrigation, the percentage of small fractions decreased in favour of the 55 mm one, or fractions above the 45-55 mm range. On average, irrigated treatments produced significantly more tubers than the conditions of natural water supply. .

  20. Soil erosion and sediment yield, a double barrel problem in South Africa's only large river network without a dam

    Science.gov (United States)

    Le Roux, Jay

    2016-04-01

    Soil erosion not only involves the loss of fertile topsoil but is also coupled with sedimentation of dams, a double barrel problem in semi-arid regions where water scarcity is frequent. Due to increasing water requirements in South Africa, the Department of Water and Sanitation is planning water resource development in the Mzimvubu River Catchment, which is the only large river network in the country without a dam. Two dams are planned including a large irrigation dam and a hydropower dam. However, previous soil erosion studies indicate that large parts of the catchment is severely eroded. Previous studies, nonetheless, used mapping and modelling techniques that represent only a selection of erosion processes and provide insufficient information about the sediment yield. This study maps and models the sediment yield comprehensively by means of two approaches over a five-year timeframe between 2007 and 2012. Sediment yield contribution from sheet-rill erosion was modelled with ArcSWAT (a graphical user interface for SWAT in a GIS), whereas gully erosion contributions were estimated using time-series mapping with SPOT 5 imagery followed by gully-derived sediment yield modelling in a GIS. Integration of the sheet-rill and gully results produced a total sediment yield map, with an average of 5 300 t km-2 y-1. Importantly, the annual average sediment yield of the areas where the irrigation dam and hydropower dam will be built is around 20 000 t km-2 y-1. Without catchment rehabilitation, the life expectancy of the irrigation dam and hydropower dam could be 50 and 40 years respectively.

  1. Comprehensive facilities plan

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-09-01

    The Ernest Orlando Lawrence Berkeley National Laboratory`s Comprehensive Facilities Plan (CFP) document provides analysis and policy guidance for the effective use and orderly future development of land and capital assets at the Berkeley Lab site. The CFP directly supports Berkeley Lab`s role as a multiprogram national laboratory operated by the University of California (UC) for the Department of Energy (DOE). The CFP is revised annually on Berkeley Lab`s Facilities Planning Website. Major revisions are consistent with DOE policy and review guidance. Facilities planing is motivated by the need to develop facilities for DOE programmatic needs; to maintain, replace and rehabilitate existing obsolete facilities; to identify sites for anticipated programmatic growth; and to establish a planning framework in recognition of site amenities and the surrounding community. The CFP presents a concise expression of the policy for the future physical development of the Laboratory, based upon anticipated operational needs of research programs and the environmental setting. It is a product of the ongoing planning processes and is a dynamic information source.

  2. Comprehensive eye evaluation algorithm

    Science.gov (United States)

    Agurto, C.; Nemeth, S.; Zamora, G.; Vahtel, M.; Soliz, P.; Barriga, S.

    2016-03-01

    In recent years, several research groups have developed automatic algorithms to detect diabetic retinopathy (DR) in individuals with diabetes (DM), using digital retinal images. Studies have indicated that diabetics have 1.5 times the annual risk of developing primary open angle glaucoma (POAG) as do people without DM. Moreover, DM patients have 1.8 times the risk for age-related macular degeneration (AMD). Although numerous investigators are developing automatic DR detection algorithms, there have been few successful efforts to create an automatic algorithm that can detect other ocular diseases, such as POAG and AMD. Consequently, our aim in the current study was to develop a comprehensive eye evaluation algorithm that not only detects DR in retinal images, but also automatically identifies glaucoma suspects and AMD by integrating other personal medical information with the retinal features. The proposed system is fully automatic and provides the likelihood of each of the three eye disease. The system was evaluated in two datasets of 104 and 88 diabetic cases. For each eye, we used two non-mydriatic digital color fundus photographs (macula and optic disc centered) and, when available, information about age, duration of diabetes, cataracts, hypertension, gender, and laboratory data. Our results show that the combination of multimodal features can increase the AUC by up to 5%, 7%, and 8% in the detection of AMD, DR, and glaucoma respectively. Marked improvement was achieved when laboratory results were combined with retinal image features.

  3. Comprehensive neurotoxicity assessment

    NARCIS (Netherlands)

    Kulig, B.M.

    1996-01-01

    Significant progress has been made in recent years in terms of both the conceptualization of neurotoxicity assessment strategies as well as in the development of behavioral techniques for evaluating neurotoxic exposures. A tiered approach, for example, has been advocated as an assessment strategy in

  4. Cultural Knowledge in News Comprehension

    DEFF Research Database (Denmark)

    Mathieu, David

    2009-01-01

    This paper presents the main lines of the design and the findings of a reception study on news comprehension. This empirical study is a comparison of the comprehension processes of Danes and French Canadians over a set of news texts from both countries. Comprehension is explored from a cultural...... perspective, through the lens of cognition and pragmatics, revealing the role played by cultural knowledge in comprehension and the underlying relationship between a text and its intended audience. It is argued that recipients ‘problematise’ the news texts, a process by which the texts answer questions...

  5. SITE COMPREHENSIVE LISTING (CERCLIS) (Superfund)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Comprehensive Environmental Response, Compensation and Liability Information System (CERCLIS) (Superfund) Public Access Database contains a selected set of...

  6. The role of reading time complexity and reading speed in text comprehension

    DEFF Research Database (Denmark)

    Wallot, Sebastian; O'Brien, Beth; Haussmann, Anna

    2014-01-01

    results show that recurrence metrics that quantify the degree of temporal structure in reading times yield better prediction of text comprehension compared to reading speed. However, the results for fractal metrics are less clear. Furthermore, prediction of text comprehension is generally strongest...

  7. Are GM Crops for Yield and Resilience Possible?

    Science.gov (United States)

    Paul, Matthew J; Nuccio, Michael L; Basu, Shib Sankar

    2018-01-01

    Crop yield improvements need to accelerate to avoid future food insecurity. Outside Europe, genetically modified (GM) crops for herbicide- and insect-resistance have been transformative in agriculture; other traits have also come to market. However, GM of yield potential and stress resilience has yet to impact on food security. Genes have been identified for yield such as grain number, size, leaf growth, resource allocation, and signaling for drought tolerance, but there is only one commercialized drought-tolerant GM variety. For GM and genome editing to impact on yield and resilience there is a need to understand yield-determining processes in a cell and developmental context combined with evaluation in the grower environment. We highlight a sugar signaling mechanism as a paradigm for this approach. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. Yield trends and yield gap analysis of major crops in the world

    OpenAIRE

    Hengsdijk, H.; Langeveld, J.W.A.

    2009-01-01

    This study aims to quantify the gap between current and potential yields of major crops in the world, and the production constraints that contribute to this yield gap. Using an expert-based evaluation of yield gaps and the literature, global and regional yields and yield trends of major crops are quantified, yield gaps evaluated by crop experts, current yield progress by breeding estimated, and different yield projections compared. Results show decreasing yield growth for wheat and rice, but ...

  9. Comprehensive approach to an assessment of removal consequences of low doses ionizing radiation influence in background of technic genius load (as an example of Pavlodar region of the Republic of Kazakstan)

    International Nuclear Information System (INIS)

    Slazhneva, T.I.; Korchevskij, A.A.; Orazgalieva, V.D.; Milyaev, A.D.

    1996-01-01

    The 'Prophylaxis' and 'Test site' comprehensive programmes are carried out for estimation of inhabitants health changes by both the Semipalatinsk test side influence and the significant technic genius pollution of environment called of industry development. It is defined, that Pavlodar region is object of radiation influence of Semipalatinsk test site. There are consequences of operation of industry enterprises (of power engineering, metallurgy, oil-chemistry) on large territory of the region. Aggravation of this region's population health was established during deepened study of sick rate with medical examination of more 12000 inhabitants and special onco-epidemical, cytological, medical genetic, immune researches. The character of chromosomal aberrations and oncological pathologies is testified about the essential influence of test site factors on health aggravation. System analysis shows, that low radiation doses are affected life quality and region population health

  10. Pragmatic Comprehension Development through Telecollaboration

    Science.gov (United States)

    Rafieyan, Vahid; Sharafi-Nejad, Maryam; Khavari, Zahra; Eng, Lin Siew; Mohamed, Abdul Rashid

    2014-01-01

    Pragmatic comprehension can be ideally developed through contact with target language speakers. This contact can be provided in English as Foreign Language contexts through telecollaboration. To test the actual effect of telecollaboration on the development of pragmatic comprehension, 30 Iranian undergraduates of English as a Foreign Language…

  11. Reading comprehension in Parkinson's disease.

    Science.gov (United States)

    Murray, Laura L; Rutledge, Stefanie

    2014-05-01

    Although individuals with Parkinson's disease (PD) self-report reading problems and experience difficulties in cognitive-linguistic functions that support discourse-level reading, prior research has primarily focused on sentence-level processing and auditory comprehension. Accordingly, the authors investigated the presence and nature of reading comprehension in PD, hypothesizing that (a) individuals with PD would display impaired accuracy and/or speed on reading comprehension tests and (b) reading performances would be correlated with cognitive test results. Eleven adults with PD and 9 age- and education-matched control participants completed tests that evaluated reading comprehension; general language and cognitive abilities; and aspects of attention, memory, and executive functioning. The PD group obtained significantly lower scores on several, but not all, reading comprehension, language, and cognitive measures. Memory, language, and disease severity were significantly correlated with reading comprehension for the PD group. Individuals in the early stages of PD without dementia or broad cognitive deficits can display reading comprehension difficulties, particularly for high- versus basic-level reading tasks. These reading difficulties are most closely related to memory, high-level language, and PD symptom severity status. The findings warrant additional research to delineate further the types and nature of reading comprehension impairments experienced by individuals with PD.

  12. Response of switchgrass yield to future climate change

    International Nuclear Information System (INIS)

    Tulbure, Mirela G; Wimberly, Michael C; Owens, Vance N

    2012-01-01

    A climate envelope approach was used to model the response of switchgrass, a model bioenergy species in the United States, to future climate change. The model was built using general additive models (GAMs), and switchgrass yields collected at 45 field trial locations as the response variable. The model incorporated variables previously shown to be the main determinants of switchgrass yield, and utilized current and predicted 1 km climate data from WorldClim. The models were run with current WorldClim data and compared with results of predicted yield obtained using two climate change scenarios across three global change models for three time steps. Results did not predict an increase in maximum switchgrass yield but showed an overall shift in areas of high switchgrass productivity for both cytotypes. For upland cytotypes, the shift in high yields was concentrated in northern and north-eastern areas where there were increases in average growing season temperature, whereas for lowland cultivars the areas where yields were projected to increase were associated with increases in average early growing season precipitation. These results highlight the fact that the influences of climate change on switchgrass yield are spatially heterogeneous and vary depending on cytotype. Knowledge of spatial distribution of suitable areas for switchgrass production under climate change should be incorporated into planning of current and future biofuel production. Understanding how switchgrass yields will be affected by future changes in climate is important for achieving a sustainable biofuels economy. (letter)

  13. A new system for seismic yield estimation of underground explosions

    International Nuclear Information System (INIS)

    Murphy, J.R.

    1991-01-01

    Research conducted over the past decade has led to the development of a number of innovative procedures for estimating the yields of underground nuclear explosions based on systematic analyses of digital seismic data recorded from these tests. In addition, a wide variety of new data regarding the geophysical environments at Soviet test locations have now become available as a result of the Joint Verification Experiment (JVE) and associated data exchanges. The system described in this paper represents an attempt to integrate all these new capabilities and data into a comprehensive operational prototype which can be used to obtain optimum seismic estimates of explosion yield together with quantitative measures of the uncertainty in those estimates. The implementation of this system has involved a wide variety of technical tasks, including the development of a comprehensive seismic database and related database access software, formulation of a graphical test site information interface for accessing available information on explosion source conditions, design of an interactive seismic analyst station for use in processing the observed data to extract the required magnitude measures and the incorporation of formal statistical analysis modules for use in yield estimation and assessment

  14. Evaluation of indigenous rhizobacterial strains with reduced dose of chemical fertilizer towards growth and yield of mustard (Brassica campestris under old alluvial soil zone of West Bengal, India

    Directory of Open Access Journals (Sweden)

    Shampa Dutta

    2017-12-01

    Full Text Available A field experiment had been carried out in the Crop Research and Seed Multiplication Farm of The University of Burdwan, West Bengal, India during the two consecutive winter seasons of 2011-2012 and 2012-2013 to study the effect of indigenous rhizospheric bacterial strains on growth, physiology and yield of mustard variety. Pseudomonas putida, Burkholderia cepacia, Burkholderia sp. and their mixture were used as seed inoculants for mustard cultivation. The experiment was laid down in a randomized complete block design (RCBD with three replications. Results revealed that indigenous inoculation (with reduced dose of chemical fertilizer significantly increased (p < 0.05 the yield of mustard as compared to uninoculated control (full recommended dose of NPK fertilizers. A combination treatment of biofertilizer and chemical fertilizer also increased plant height, plant biomass and other yield components compared to control. The comprehensive approach of plant growth promoting rhizobacteria (PGPR in agriculturally important crops should be carried out to explore the hidden potential of PGPR and to promote the quality and yield of crop under field conditions. Keywords: Indigenous rhizobacteria, Mustard, PGPR, Yield

  15. (Context comprehension in digital social media

    Directory of Open Access Journals (Sweden)

    Alana Kercia Barros Demétrio

    2016-10-01

    Full Text Available In this article, we address the reading issue from the point of view of complexity. Understanding, according to Beaugrande (1997, that the text is a communicative event whose configuration involves elements of different nature, including the participants of interaction, we think that traditional approaches to reading, even those which are focused on interaction, do not satisfactorily bolster comprehension of this phenomenon. In order to analyze how aspects that characterize reading as a complex activity show at (context comprehension in digital social media, we leaned on the articles by Pellanda (2005 and by Franco (2011 and we were supported by the autopoietic theory by Maturana and Varela (1995, as well as by the concepts of emergency and incorporation by Hanks (2008. Through the analysis of two examples of interaction conveyed in virtual environment, we observed that reading triggers readers’ autopoiesis as living systems.

  16. Yields of historical exploration programs

    International Nuclear Information System (INIS)

    Huslende, T.

    1995-01-01

    The paper relates to an method of evaluation developed for analysing the yield of historical exploration programs by computerized simulation. The most important elements show in coarse features how the results can be used in the different analyses. The evaluation is to be executed annually for the comparison and sorting of data from different offshore sites. Topics are exploration evaluation study, evaluation process, handling of exploration costs, discovered reserves, development projects, cash flow analysis, analysis of results, finding cost, international comparison. 1 ref., 11 figs

  17. Yield gap analysis in long-term experiments with intensive rice cultivation

    International Nuclear Information System (INIS)

    Laureles, E.V.; Correa, T. Jr.; Buresh, R.J.

    2007-01-01

    The long-term continuous cropping experiment at IRRI is cultivated with three rice crops in a year, making it the world's most intensively cropped long-term rice experiment. The availability of comprehensive rice production records, compiled weather data, and tested crop models provides a means to evaluate long-term trends in measured and potential yields and yield gaps in this rice production system. Yield trends were assessed using the highest yielding cultivar in each cropping season from 1979 to 2005. Potential yield of the highest yielding cultivar in each season was determined using three rice models (ORYZA, TERM, and CERES) run with the actual transplanting and harvest dates for the cultivar. The yield gap was determined from the difference between the simulated potential grain yield and the measured grain yield. Measured and potential yields and the yield gap varied across seasons and years. Measured yields were higher in the dry season than in the early and late wet seasons. The yield gap tended to be higher in the wet season than in the dry season. Climatic parameters, particularly solar radiation, influenced the performance of rice cultivars. The relatively larger yield gaps in the late wet season than in the dry season were associated with increased spikelet sterility. The cumulative measured yield for the three annual rice crop was near 80 percent of the annual yield potential in years with best practices for fertilizer N and crop management. The long term trends suggest that effective timing and rates of N fertilization and effective control of diseases were critical in achieving 80 percent of the annual yield potential

  18. A crop model-based approach for sunflower yields

    NARCIS (Netherlands)

    Belo Leite, Dal J.G.; Nunes Vieira da Silva, J.V.; Barbosa Justino, F.; Ittersum, van M.K.

    2014-01-01

    Pushed by the Brazilian biodiesel policy, sunflower (Helianthus annuus L.) production is becoming increasingly regarded as an option to boost farmers' income, particularly under semi-arid conditions. Biodiesel related opportunities increase the demand for decision-making information at different

  19. Quantum molecular dynamics approach to estimate spallation yield ...

    Indian Academy of Sciences (India)

    Consequently, the need for reliable data to design and construct spallation neutron sources has prompted ... A major disadvantage of the QMD code .... have estimated the average neutron multiplicities per primary reaction and kinetic energy.

  20. Root-yield performance of pre-release sweet potato genotypes in ...

    African Journals Online (AJOL)

    SARAH

    2013-05-29

    May 29, 2013 ... consideration all yield components which affect the total root yield. Such a focused approach with well- defined selection objectives ensures positive progress early in the breeding program. Interrelationships among yield components have been investigated by Grüneberg et al. (2005) in. Peru and Çalişkan ...

  1. The minimum yield in channeling

    International Nuclear Information System (INIS)

    Uguzzoni, A.; Gaertner, K.; Lulli, G.; Andersen, J.U.

    2000-01-01

    A first estimate of the minimum yield was obtained from Lindhard's theory, with the assumption of a statistical equilibrium in the transverse phase-space of channeled particles guided by a continuum axial potential. However, computer simulations have shown that this estimate should be corrected by a fairly large factor, C (approximately equal to 2.5), called the Barrett factor. We have shown earlier that the concept of a statistical equilibrium can be applied to understand this result, with the introduction of a constraint in phase-space due to planar channeling of axially channeled particles. Here we present an extended test of these ideas on the basis of computer simulation of the trajectories of 2 MeV α particles in Si. In particular, the gradual trend towards a full statistical equilibrium is studied. We also discuss the introduction of this modification of standard channeling theory into descriptions of the multiple scattering of channeled particles (dechanneling) by a master equation and show that the calculated minimum yields are in very good agreement with the results of a full computer simulation

  2. Spatio-temporal dynamics of maize yield water constraints under climate change in Spain.

    Directory of Open Access Journals (Sweden)

    Rosana Ferrero

    Full Text Available Many studies have analyzed the impact of climate change on crop productivity, but comparing the performance of water management systems has rarely been explored. Because water supply and crop demand in agro-systems may be affected by global climate change in shaping the spatial patterns of agricultural production, we should evaluate how and where irrigation practices are effective in mitigating climate change effects. Here we have constructed simple, general models, based on biological mechanisms and a theoretical framework, which could be useful in explaining and predicting crop productivity dynamics. We have studied maize in irrigated and rain-fed systems at a provincial scale, from 1996 to 2009 in Spain, one of the most prominent "hot-spots" in future climate change projections. Our new approach allowed us to: (1 evaluate new structural properties such as the stability of crop yield dynamics, (2 detect nonlinear responses to climate change (thresholds and discontinuities, challenging the usual linear way of thinking, and (3 examine spatial patterns of yield losses due to water constraints and identify clusters of provinces that have been negatively affected by warming. We have reduced the uncertainty associated with climate change impacts on maize productivity by improving the understanding of the relative contributions of individual factors and providing a better spatial comprehension of the key processes. We have identified water stress and water management systems as being key causes of the yield gap, and detected vulnerable regions where efforts in research and policy should be prioritized in order to increase maize productivity.

  3. Personality attributes of children with behavior problems. An exploratory analysis with the Exner Comprehensive System of the Rorschach Inkblot Test and implications for the socio-historical clinical practice approach

    Directory of Open Access Journals (Sweden)

    Saraiva A. B.

    2016-12-01

    Full Text Available From a Relational-Historical theoretical framework applied to clinical psychological practice, this study examines the data set underlying the personality attributes of different groups of children with behavior problems as demonstrated on the Rorschach Inkblot Test. To define the groups, categories were established from parents’ descriptions of their own children. This procedure allowed for the formation of three major psychological profiles: hyperkinetic, oppositional defiant, and antisocial (Saraiva & Ferreira, 2016. The major goal of this study is data exploration in a clinical setting, in order to investigate whether and in what ways groups of hyperkinetic, oppositional defiant, and antisocial children differ. These profile characteristics are important issues embraced by both psychodiagnosis and psychotherapy. The participants for this study were 39 Portuguese children, who were private clinic clients; there were 24 boys and 15 girls between the ages of 6 and 14. Their personality attributes were measured using the Rorschach Inkblot Test (Rorschach, 1994, and the Comprehensive System developed by Exner (1991, 1993, 2000 was applied, with the support of the clinical interpretation provided by Quintino-Aires (1999; 2009; 2012; 2014. Comparison of the three profiles showed four common aspects of personality structure: a deficit in cognitive perceptual skills, lack of self-control, limited relational skills, and low self-esteem. Differences in the three profiles revealed factors related to the functional characteristics of specific behavior patterns. Children with the hyperkinetic psychological profile show factors of difficulty in controlling their activity, impulsivity, and overlapping emotions about conscious action. Those with the oppositional defiant profile revealed factors of low self-confidence, low trust in others, high pessimism, loneliness, and structural stress. Finally, those with the antisocial profile had factors of a deficit

  4. A developmental study of proverb comprehension.

    Science.gov (United States)

    Resnick, D A

    1982-09-01

    Growth in proverb comprehension was hypothesized to result from the gradual emergence of cognitive abilities reflected in a sequence of increasingly complex abilities: story matching, transfer of relations, desymbolization, proverb matching, and paraphrase. Items for these abilities for each of 10 proverbs of two structural types were administered in three test sessions to 438 students in grades three to seven. An analogy subtest was used to measure general intelligence. ANOVA yielded significant main effects for grade, tasks, and proverbs (all p's less than .01). A significant task x proverb interaction (p less than .01) revealed the difficulty of precise control over the language of the items. Proverb structure had no measurable impact on difficulty. Analogy score was a significant factor in performance (p less than .01) but not as potent as age (p less than .01). The sequential order of abilities received only weak confirmation, though tasks did correlate among themselves with medium strength (r's = .50-.70). Individual interviews added a qualitative dimension to the findings. The suitability of cognitive hierarchical models for proverb comprehension was questioned.

  5. Comprehensive Error Rate Testing (CERT)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Centers for Medicare and Medicaid Services (CMS) implemented the Comprehensive Error Rate Testing (CERT) program to measure improper payments in the Medicare...

  6. Closing yield gaps in China by empowering smallholder farmers

    Science.gov (United States)

    Zhang, Weifeng; Cao, Guoxin; Li, Xiaolin; Zhang, Hongyan; Wang, Chong; Liu, Quanqing; Chen, Xinping; Cui, Zhenling; Shen, Jianbo; Jiang, Rongfeng; Mi, Guohua; Miao, Yuxin; Zhang, Fusuo; Dou, Zhengxia

    2016-09-01

    Sustainably feeding the world’s growing population is a challenge, and closing yield gaps (that is, differences between farmers’ yields and what are attainable for a given region) is a vital strategy to address this challenge. The magnitude of yield gaps is particularly large in developing countries where smallholder farming dominates the agricultural landscape. Many factors and constraints interact to limit yields, and progress in problem-solving to bring about changes at the ground level is rare. Here we present an innovative approach for enabling smallholders to achieve yield and economic gains sustainably via the Science and Technology Backyard (STB) platform. STB involves agricultural scientists living in villages among farmers, advancing participatory innovation and technology transfer, and garnering public and private support. We identified multifaceted yield-limiting factors involving agronomic, infrastructural, and socioeconomic conditions. When these limitations and farmers’ concerns were addressed, the farmers adopted recommended management practices, thereby improving production outcomes. In one region in China, the five-year average yield increased from 67.9% of the attainable level to 97.0% among 71 leading farmers, and from 62.8% to 79.6% countywide (93,074 households); this was accompanied by resource and economic benefits.

  7. Geoelectrical parameter-based multivariate regression borehole yield model for predicting aquifer yield in managing groundwater resource sustainability

    Directory of Open Access Journals (Sweden)

    Kehinde Anthony Mogaji

    2016-07-01

    Full Text Available This study developed a GIS-based multivariate regression (MVR yield rate prediction model of groundwater resource sustainability in the hard-rock geology terrain of southwestern Nigeria. This model can economically manage the aquifer yield rate potential predictions that are often overlooked in groundwater resources development. The proposed model relates the borehole yield rate inventory of the area to geoelectrically derived parameters. Three sets of borehole yield rate conditioning geoelectrically derived parameters—aquifer unit resistivity (ρ, aquifer unit thickness (D and coefficient of anisotropy (λ—were determined from the acquired and interpreted geophysical data. The extracted borehole yield rate values and the geoelectrically derived parameter values were regressed to develop the MVR relationship model by applying linear regression and GIS techniques. The sensitivity analysis results of the MVR model evaluated at P ⩽ 0.05 for the predictors ρ, D and λ provided values of 2.68 × 10−05, 2 × 10−02 and 2.09 × 10−06, respectively. The accuracy and predictive power tests conducted on the MVR model using the Theil inequality coefficient measurement approach, coupled with the sensitivity analysis results, confirmed the model yield rate estimation and prediction capability. The MVR borehole yield prediction model estimates were processed in a GIS environment to model an aquifer yield potential prediction map of the area. The information on the prediction map can serve as a scientific basis for predicting aquifer yield potential rates relevant in groundwater resources sustainability management. The developed MVR borehole yield rate prediction mode provides a good alternative to other methods used for this purpose.

  8. Comprehension instruction research-based best practices

    CERN Document Server

    Parris, Sheri R; Morrow, Lesley Mandel

    2015-01-01

    All key issues of research and practice in comprehension instruction are addressed in this highly regarded professional resource and course text. Leading scholars examine the processes that enable students to make meaning from what they read--and how this knowledge can be applied to improve teaching at all grade levels. Best practices for meeting the needs of diverse elementary and secondary students are identified. Essential topics include strategies for comprehending different types of texts, the impact of the Common Core State Standards (CCSS), cutting-edge assessment approaches, and the gr

  9. Comprehensive Lifecycle for Assuring System Safety

    Science.gov (United States)

    Knight, John C.; Rowanhill, Jonathan C.

    2017-01-01

    CLASS is a novel approach to the enhancement of system safety in which the system safety case becomes the focus of safety engineering throughout the system lifecycle. CLASS also expands the role of the safety case across all phases of the system's lifetime, from concept formation to decommissioning. As CLASS has been developed, the concept has been generalized to a more comprehensive notion of assurance becoming the driving goal, where safety is an important special case. This report summarizes major aspects of CLASS and contains a bibliography of papers that provide additional details.

  10. Comprehensive update of the atomic mass predictions

    International Nuclear Information System (INIS)

    Haustein, P.E.

    1987-01-01

    A project has been completed recently for a comprehensive update of atomic mass predictions. This last occurred in 1976. Over the last 10 years the reliability of these earlier predictions (and others published later) has been analyzed by comparisons of the predictions with new masses from isotopes that were not in the experimental data base when the predictions were prepared. This analysis has highlighted distinct systematic features in various models which frequently result in poor predictions for nuclei that lie far from stability. An overview of the new predictions from models with different theoretical approaches will be presented

  11. Control del cáncer en el Perú: un abordaje integral para un problema de salud pública Cancer control in Peru: a comprehensive approach to a public health issue

    Directory of Open Access Journals (Sweden)

    Gustavo Sarria-Bardales

    2013-03-01

    Full Text Available El cáncer como problema de salud pública es complejo y cambiante, obliga a afrontarlo mediante una estrategia integral, transversal, coherente y sostenible basada en experiencias previas y proyectadas al alarmante incremento que muestra esta condición a nivel global. Es imprescindible buscar y respetar consensos, impulsar nuevas tecnologías e investigar estrategias con sensibilidad cultural adecuadas a las comunidades y en las cuales éstas participen activamente. Se hace impostergable reforzar el componente educacional e introducir las nuevas tecnologías de información y comunicación, reforzando el sistema desde el nivel primario de atención. Nuestro objetivo debe ser la disminución de la morbimortalidad por cáncer en el mediano y largo plazo. En este artículo se describen algunas de las medidas implementadas para este fin. Consideramos que todas las estrategias de prevención del cáncer deben aplicarse en el contexto de actividades transversales orientadas a prevenir otras enfermedades crónicas, con criterio de salud públicaCancer as a public health issue is changing and complex. It calls for a comprehensive, coherent and horizontal strategy based on previous experiences and considering the alarming increase of this condition worldwide. Therefore, it is imperative to reach and respect consensuses, to promote new technologies and study culturally sensitive strategies that adapt to the communities and involve people to actively participate. Likewise, strengthening the educational component and introducing new information and communication technologies cannot wait, while strengthening the system, from the primary health care level at the same time. Our goal should be to reduce cancer morbidity and mortality rates in the medium and long terms. This article describes some of the measures implemented for that purpose. We consider that all cancer preventive strategies should be applied in the context of transversal activities oriented

  12. SMART STRATEGY TO BOOST STUDENTS’ READING COMPREHENSION

    Directory of Open Access Journals (Sweden)

    Muhammad Lukman Syafi’i

    2015-05-01

    Full Text Available Reading as one of language skills plays significant roles in the teaching English as a foreign language. Since the teacher still uses the conventional way to teach reading, students‘ ability in reading comprehension seems still unsatisfactory yet. So, teacher should explore and develop new strategies. One of strategies in reading comprehension that can trigger our students to attain that purpose is SMART (Self Monitoring Approach for Reading and Thinking strategy. This study is developing SMART strategy to boost the reading comprehension achievement of the ninth grade students. The research applies a collaborative classroom action research design in which the researcher and the collaborative teacher work together in preparing a suitable procedure of SMART strategy, designing the lesson plan, determining the criteria of success, implementing the action, observing, and doing reflection. The finding indicated that SMART strategy was successful to enhance students‘ motivation to be actively involved in the instructional process. The improvement on the students‘ participation was 75% in Cycle 1 and 87% in Cycle 2.

  13. Crop yield response to climate change varies with cropping intensity.

    Science.gov (United States)

    Challinor, Andrew J; Parkes, Ben; Ramirez-Villegas, Julian

    2015-04-01

    Projections of the response of crop yield to climate change at different spatial scales are known to vary. However, understanding of the causes of systematic differences across scale is limited. Here, we hypothesize that heterogeneous cropping intensity is one source of scale dependency. Analysis of observed global data and regional crop modelling demonstrate that areas of high vs. low cropping intensity can have systematically different yields, in both observations and simulations. Analysis of global crop data suggests that heterogeneity in cropping intensity is a likely source of scale dependency for a number of crops across the globe. Further crop modelling and a meta-analysis of projected tropical maize yields are used to assess the implications for climate change assessments. The results show that scale dependency is a potential source of systematic bias. We conclude that spatially comprehensive assessments of climate impacts based on yield alone, without accounting for cropping intensity, are prone to systematic overestimation of climate impacts. The findings therefore suggest a need for greater attention to crop suitability and land use change when assessing the impacts of climate change. © 2015 John Wiley & Sons Ltd.

  14. Using Low Resolution Satellite Imagery for Yield Prediction and Yield Anomaly Detection

    Directory of Open Access Journals (Sweden)

    Oscar Rojas

    2013-04-01

    Full Text Available Low resolution satellite imagery has been extensively used for crop monitoring and yield forecasting for over 30 years and plays an important role in a growing number of operational systems. The combination of their high temporal frequency with their extended geographical coverage generally associated with low costs per area unit makes these images a convenient choice at both national and regional scales. Several qualitative and quantitative approaches can be clearly distinguished, going from the use of low resolution satellite imagery as the main predictor of final crop yield to complex crop growth models where remote sensing-derived indicators play different roles, depending on the nature of the model and on the availability of data measured on the ground. Vegetation performance anomaly detection with low resolution images continues to be a fundamental component of early warning and drought monitoring systems at the regional scale. For applications at more detailed scales, the limitations created by the mixed nature of low resolution pixels are being progressively reduced by the higher resolution offered by new sensors, while the continuity of existing systems remains crucial for ensuring the availability of long time series as needed by the majority of the yield prediction methods used today.

  15. Citizen science and remote sensing for crop yield gap analysis

    NARCIS (Netherlands)

    Beza, Eskender Andualem

    2017-01-01

    The world population is anticipated to be around 9.1 billion in 2050 and the challenge is how to feed this huge number of people without affecting natural ecosystems. Different approaches have been proposed and closing the ‘yield gap’ on currently available agricultural lands is one of them. The

  16. Comprehensive analysis of transport aircraft flight performance

    Science.gov (United States)

    Filippone, Antonio

    2008-04-01

    This paper reviews the state-of-the art in comprehensive performance codes for fixed-wing aircraft. The importance of system analysis in flight performance is discussed. The paper highlights the role of aerodynamics, propulsion, flight mechanics, aeroacoustics, flight operation, numerical optimisation, stochastic methods and numerical analysis. The latter discipline is used to investigate the sensitivities of the sub-systems to uncertainties in critical state parameters or functional parameters. The paper discusses critically the data used for performance analysis, and the areas where progress is required. Comprehensive analysis codes can be used for mission fuel planning, envelope exploration, competition analysis, a wide variety of environmental studies, marketing analysis, aircraft certification and conceptual aircraft design. A comprehensive program that uses the multi-disciplinary approach for transport aircraft is presented. The model includes a geometry deck, a separate engine input deck with the main parameters, a database of engine performance from an independent simulation, and an operational deck. The comprehensive code has modules for deriving the geometry from bitmap files, an aerodynamics model for all flight conditions, a flight mechanics model for flight envelopes and mission analysis, an aircraft noise model and engine emissions. The model is validated at different levels. Validation of the aerodynamic model is done against the scale models DLR-F4 and F6. A general model analysis and flight envelope exploration are shown for the Boeing B-777-300 with GE-90 turbofan engines with intermediate passenger capacity (394 passengers in 2 classes). Validation of the flight model is done by sensitivity analysis on the wetted area (or profile drag), on the specific air range, the brake-release gross weight and the aircraft noise. A variety of results is shown, including specific air range charts, take-off weight-altitude charts, payload-range performance

  17. Yield trends and yield gap analysis of major crops in the world

    NARCIS (Netherlands)

    Hengsdijk, H.; Langeveld, J.W.A.

    2009-01-01

    This study aims to quantify the gap between current and potential yields of major crops in the world, and the production constraints that contribute to this yield gap. Using an expert-based evaluation of yield gaps and the literature, global and regional yields and yield trends of major crops are

  18. A Metabolomic Approach Applied to a Liquid Chromatography Coupled to High-Resolution Tandem Mass Spectrometry Method (HPLC-ESI-HRMS/MS): Towards the Comprehensive Evaluation of the Chemical Composition of Cannabis Medicinal Extracts.

    Science.gov (United States)

    Citti, Cinzia; Battisti, Umberto Maria; Braghiroli, Daniela; Ciccarella, Giuseppe; Schmid, Martin; Vandelli, Maria Angela; Cannazza, Giuseppe

    2018-03-01

    Cannabis sativa L. is a powerful medicinal plant and its use has recently increased for the treatment of several pathologies. Nonetheless, side effects, like dizziness and hallucinations, and long-term effects concerning memory and cognition, can occur. Most alarming is the lack of a standardised procedure to extract medicinal cannabis. Indeed, each galenical preparation has an unknown chemical composition in terms of cannabinoids and other active principles that depends on the extraction procedure. This study aims to highlight the main differences in the chemical composition of Bediol® extracts when the extraction is carried out with either ethyl alcohol or olive oil for various times (0, 60, 120 and 180 min for ethyl alcohol, and 0, 60, 90 and 120 min for olive oil). Cannabis medicinal extracts (CMEs) were analysed by liquid chromatography coupled to high-resolution tandem mass spectrometry (LC-MS/MS) using an untargeted metabolomics approach. The data sets were processed by unsupervised multivariate analysis. Our results suggested that the main difference lies in the ratio of acid to decarboxylated cannabinoids, which dramatically influences the pharmacological activity of CMEs. Minor cannabinoids, alkaloids, and amino acids contributing to this difference are also discussed. The main cannabinoids were quantified in each extract applying a recently validated LC-MS and LC-UV method. Notwithstanding the use of a standardised starting plant material, great changes are caused by different extraction procedures. The metabolomics approach is a useful tool for the evaluation of the chemical composition of cannabis extracts. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  19. Memory mechanisms supporting syntactic comprehension.

    Science.gov (United States)

    Caplan, David; Waters, Gloria

    2013-04-01

    Efforts to characterize the memory system that supports sentence comprehension have historically drawn extensively on short-term memory as a source of mechanisms that might apply to sentences. The focus of these efforts has changed significantly in the past decade. As a result of changes in models of short-term working memory (ST-WM) and developments in models of sentence comprehension, the effort to relate entire components of an ST-WM system, such as those in the model developed by Baddeley (Nature Reviews Neuroscience 4: 829-839, 2003) to sentence comprehension has largely been replaced by an effort to relate more specific mechanisms found in modern models of ST-WM to memory processes that support one aspect of sentence comprehension--the assignment of syntactic structure (parsing) and its use in determining sentence meaning (interpretation) during sentence comprehension. In this article, we present the historical background to recent studies of the memory mechanisms that support parsing and interpretation and review recent research into this relation. We argue that the results of this research do not converge on a set of mechanisms derived from ST-WM that apply to parsing and interpretation. We argue that the memory mechanisms supporting parsing and interpretation have features that characterize another memory system that has been postulated to account for skilled performance-long-term working memory. We propose a model of the relation of different aspects of parsing and interpretation to ST-WM and long-term working memory.

  20. Measurment and Reporting of Comprehensive Income: Search ...

    African Journals Online (AJOL)

    Measurment and Reporting of Comprehensive Income: Search, Challenges, ... of periods of stable and unstable economic situation and satisfies varied users' ... Keywords: Historical accounting; comprehensive income; asset valuation model.