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Sample records for compensation mcp gun

  1. Emittance compensation of CW DC-gun photoinjector

    International Nuclear Information System (INIS)

    Li Peng; Wu Dai; Xu Zhou; Li Ming; Yang Xingfan

    2011-01-01

    Emittance growth induced by space charge effect is very important, especially for CW DC-gun photoinjector. In this work, the linear space charge force and its effect on electron beam transverse emittance are studied, and the principle and properties of emittance compensation by solenoid are analyzed. The CAEP DC-gun photoinjector with a solenoid is also simulated by code Parmela. Simulated results indicate that the normalized transverse emittance of an 80 pC bunch at the 350 keV DC-gun ex-it is 5.14 mm · mrad. And after compensated by a solenoid, it becomes 1.27 mm · mrad. The emittance of beam is well compensated. (authors)

  2. Analysis of emittance compensation and simulation results to photo-cathode RF gun

    CERN Document Server

    LiuShengGuang

    2002-01-01

    The emittance compensation technology will be used on the photo-cathode RF gun for Shanghai SDUV-FEL. The space charge force and its effect on electron beam transverse emittance in RF gun is studied, the principle of emittance compensation in phase-space is discussed. The authors have designed a compensation solenoid and calculated its magnetic field distribution. Its performance has been studied by the code PARMELA. A simulation result indicates that the normalized transverse RMS emittance for electron beam of 1.5 nC is 1.612 pi mm centre dot mrad, electron energy E = 5.71 MeV

  3. Simulations of the BNL/SLAC/UCLA 1.6 cell emittance compensated photocathode RF gun low energy beam line

    International Nuclear Information System (INIS)

    Palmer, D.T.; Miller, R.H.; Winick, H.

    1995-01-01

    A dedicated low energy (2 to 10 MeV) experimental beam line is now under construction at Brookhaven National Laboratories Accelerator Test Facility (BNL/ATF) for photocathode RF gun testing and photoemission experiments. The design of the experimental line, using the 1.6 cell photocathode RF gun developed by the BNL/SLAC/UCLA RF gun collaboration is presented. Detailed beam dynamics simulations were performed for the 1.6 cell RF gun injector using a solenoidal emittance compensation technique. An experimental program for testing the 1.6 cell RF gun is presented. This program includes beam loading caused by dark current, higher order mode field measurements, integrated and slice emittance measurements using a pepper-pot and RF kicker cavity

  4. Determination of the Basis for Temperature Compensation in ETC Ignited Solid Propellant Guns

    National Research Council Canada - National Science Library

    Pesce-Rodriguez, R. A; Beyer, R. A

    2004-01-01

    A series of experiments and reanalysis of previously published results has led to the discovery of the key interaction between the plasma of an electrothermal igniter and the gun propellant in large caliber cannon...

  5. Studies of MCP properties

    International Nuclear Information System (INIS)

    Lehmann, A; Britting, A; Eyrich, W; Uhlig, F

    2009-01-01

    Cherenkov detectors of the DIRC type will be used for the particle identification of the PANDA experiment at FAIR. Because of their advantageous properties inside a magnetic field micro-channel plate (MCP) photomultipliers (PMT) are very attractive photon sensors for the two PANDA DIRCs. Various types of MCP-PMTs were investigated. Their gains and their time resolutions were measured as a function of the magnitude and the direction of a magnetic field. It was found that with a pore size of ≤ 10 μm efficient single photon detection is possible even at 2 Tesla if the field direction is close to parallel to the PMT axis. The gain of most of the studied MCP-PMTs remains stable up to a photon density of roughly 1 MHz/cm 2 , while the new Hamamatsu R10754-00-L4 can stand rates of about 10 MHz/cm 2 before the gain starts decreasing. The time resolution of all investigated MCP-PMTs was better than 50 ps (σ). The response of the multi-anode MCP-PMTs was scanned as a function of the position of the photo cathode plane in particular to measure the crosstalk among adjacent pixels. Most of the sensors show a satisfactory behavior.

  6. Gun Play

    Science.gov (United States)

    Mechling, Jay

    2008-01-01

    Biology and the particular gun culture of the United States come together to explain the persistent and powerful attraction of American boys to both real guns and toy guns. The 1990s saw adults begin to conflate "the gun problem" with "the boy problem," sparking attempts (largely failed) to banish toy guns from homes and…

  7. LCLS Gun Solenoid Design Considerations

    International Nuclear Information System (INIS)

    Schmerge, John

    2010-01-01

    The LCLS photocathode rf gun requires a solenoid immediately downstream for proper emittance compensation. Such a gun and solenoid have been operational at the SSRL Gun Test Facility (GTF) for over eight years. Based on magnetic measurements and operational experience with the GTF gun solenoid multiple modifications are suggested for the LCLS gun solenoid. The modifications include adding dipole and quadrupole correctors inside the solenoid, increasing the bore to accommodate the correctors, decreasing the mirror plate thickness to allow the solenoid to move closer to the cathode, cutouts in the mirror plate to allow greater optical clearance with grazing incidence cathode illumination, utilizing pancake coil mirror images to compensate the first and second integrals of the transverse fields and incorporating a bipolar power supply to allow for proper magnet standardization and quick polarity changes. This paper describes all these modifications plus the magnetic measurements and operational experience leading to the suggested modifications.

  8. Gun Safety

    Science.gov (United States)

    Many U.S. households have guns, but they can cause harm if not handled properly. Here are some things you can do to keep yourself and ... safe: Teach children that they shouldn't touch guns and that if they see a gun, to ...

  9. Gun Safety (For Kids)

    Science.gov (United States)

    ... Staying Safe Videos for Educators Search English Español Gun Safety KidsHealth / For Kids / Gun Safety What's in ... from guns outside the home. If You Have Guns in Your Home If your parents keep guns ...

  10. Sanoli Gun

    Indian Academy of Sciences (India)

    Home; Journals; Proceedings – Mathematical Sciences. Sanoli Gun. Articles written in Proceedings – Mathematical Sciences. Volume 119 Issue 3 June 2009 pp 275-281. Remarks on some Zero-Sum Theorems · S D Adhikari Sanoli Gun Purusottam Rath · More Details Abstract Fulltext PDF. In the present paper, we give a ...

  11. Gun Control, Gun Ownership, and Suicide Prevention.

    Science.gov (United States)

    Lester, David

    1988-01-01

    Explored relationship between the extent of gun ownership and the strictness of gun control laws to suicide and homicide rates in the nine major geographic regions of the United States. Found gun ownership, rather than the strictness of gun control laws, was the strongest correlate of the rates of suicide and homicide by guns. (Author)

  12. Electron gun

    International Nuclear Information System (INIS)

    Chen, H.-Y.; Hughes, R.H.

    1979-01-01

    The invention described relates to cathode ray tubes, and particularly to color picture tubes of the type useful in home television receivers and therefore to electron guns. The invention is especially applicable to self-converging tube-yoke combinations with shadow mask tubes of the type having plural-beam in-line guns disposed in a horizontal plane, an apertured mask with vertically oriented slit-shaped apertures, and a screen with vertically oriented phosphor stripes. The invention is not, however, limited to use in such tubes and may in fact be used, e.g., in dot-type shadow mask tubes and index-type tubes. (Auth.)

  13. Spectrometer gun

    Science.gov (United States)

    Waechter, David A.; Wolf, Michael A.; Umbarger, C. John

    1985-01-01

    A hand-holdable, battery-operated, microprocessor-based spectrometer gun includes a low-power matrix display and sufficient memory to permit both real-time observation and extended analysis of detected radiation pulses. Universality of the incorporated signal processing circuitry permits operation with various detectors having differing pulse detection and sensitivity parameters.

  14. Water gun vs air gun: A comparison

    Science.gov (United States)

    Hutchinson, D.R.; Detrick, R. S.

    1984-01-01

    The water gun is a relatively new marine seismic sound source that produces an acoustic signal by an implosive rather than explosive mechanism. A comparison of the source characteristics of two different-sized water guns with those of conventional air guns shows the the water gun signature is cleaner and much shorter than that of a comparable-sized air gun: about 60-100 milliseconds (ms) for an 80-in3. (1.31-liter (I)) water gun compared with several hundred ms for an 80-in3. (1.31-1) air gun. The source spectra of water guns are richer in high frequencies (>200 Hz) than are those of air guns, but they also have less energy than those of air guns at low frequencies. A comparison between water gun and air gun reflection profiles in both shallow (Long Island Sound)-and deep (western Bermuda Rise)-water settings suggests that the water gun offers a good compromise between very high resolution, limited penetration systems (e.g. 3.5-kHz profilers and sparkers) and the large volume air guns and tuned air gun arrays generally used where significant penetration is required. ?? 1984 D. Reidel Publishing Company.

  15. SSRL photocathode RF gun test stand

    International Nuclear Information System (INIS)

    Hernandez, M.; Baltay, M.; Boyce, A.

    1995-01-01

    A photocathode RF gun test stand designed for the production and study of high brightness electron beams will be constructed at SSRL. The beam will be generated from a laser driven third generation photocathode RF gun being developed in collaboration with BNL, LBL, and UCLA. The 3-5 [MeV] beam from the gun will be accelerated using a SLAC three meter S-band accelerator section, in order to achieve the desired low emittance beam, emittance compensation with solenoidal focusing will be employed

  16. ELECTRON GUN

    Science.gov (United States)

    Christofilos, N.C.; Ehlers, K.W.

    1960-04-01

    A pulsed electron gun capable of delivering pulses at voltages of the order of 1 mv and currents of the order of 100 amperes is described. The principal novelty resides in a transformer construction which is disposed in the same vacuum housing as the electron source and accelerating electrode structure of the gun to supply the accelerating potential thereto. The transformer is provided by a plurality of magnetic cores disposed in circumferentially spaced relation and having a plurality of primary windings each inductively coupled to a different one of the cores, and a helical secondary winding which is disposed coaxially of the cores and passes therethrough in circumferential succession. Additional novelty resides in the disposition of the electron source cathode filament input leads interiorly of the transformer secondary winding which is hollow, as well as in the employment of a half-wave filament supply which is synchronously operated with the transformer supply such that the transformer is pulsed during the zero current portions of the half-wave cycle.

  17. ION GUN

    Science.gov (United States)

    Dandl, R.A.

    1961-10-24

    An ion gun is described for the production of an electrically neutral ionized plasma. The ion gun comprises an anode and a cathode mounted in concentric relationship with a narrow annulus between. The facing surfaces of the rear portions of the anode and cathode are recessed to form an annular manifold. Positioned within this manifold is an annular intermediate electrode aligned with the an nulus between the anode and cathode. Gas is fed to the manifold and an arc discharge is established between the anode and cathode. The gas is then withdrawn from the manifold through the annulus between the anode and cathode by a pressure differential. The gas is then ionized by the arc discharge across the annulus. The ionized gas is withdrawn from the annulus by the combined effects of the pressure differential and a collimating magnetic field. In a 3000 gauss magnetic field, an arc voltage of 1800 volts, and an arc current of 0.2 amp, a plasma of about 3 x 10/sup 11/ particles/cc is obtained. (AEC)

  18. Gun ownership and social gun culture.

    Science.gov (United States)

    Kalesan, Bindu; Villarreal, Marcos D; Keyes, Katherine M; Galea, Sandro

    2016-06-01

    We assessed gun ownership rates in 2013 across the USA and the association between exposure to a social gun culture and gun ownership. We used data from a nationally representative sample of 4000 US adults, from 50 states and District of Columbia, aged >18 years to assess gun ownership and social gun culture performed in October 2013. State-level firearm policy information was obtained from the Brady Law Center and Injury Prevention and Control Center. One-third of Americans reported owning a gun, ranging from 5.2% in Delaware to 61.7% in Alaska. Gun ownership was 2.25-times greater among those reporting social gun culture (PR=2.25, 95% CI 2.02 to 2.52) than those who did not. In conclusion, we found strong association between social gun culture and gun ownership. Gun cultures may need to be considered for public health strategies that aim to change gun ownership in the USA. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  19. Encyclopedia of Gun Control and Gun Rights.

    Science.gov (United States)

    Utter, Glenn H.

    This reference volume provides information on gun control and gun rights, including resources on the debate surrounding the Second Amendment and individuals and organizations focused on gun issues, along with statutes, court cases, events, and publications surrounding this current topic. Highlighted are the important organizations and their…

  20. Ion Feedback Suppression Using Inclined MCP Holes in a Single-MCP+Micromegas+Pads Detector

    International Nuclear Information System (INIS)

    Va'vra, J.; Sumiyoshi, T.

    2005-01-01

    We show that the ion backflow to photocathode can be completely suppressed if one uses inclined MCP holes in a presence of magnetic field. The inclined hole angles are chosen to be aligned with the Lorentz electron angle allowing the electron transmission and amplification, while positive ions, traveling along a different angle, are caught on the MCP hole walls. The detector under investigation is a new gaseous detector structure based on a tandem of two parts, a single MCP (Microchannel) plate, a Micromegas with pad readout. We are aiming to develop a gaseous photon detector with the Bialkali photocathode, however, one could use some ideas in the paper for other types of detectors

  1. Gun control saves lives

    African Journals Online (AJOL)

    gun control legislation. One study estimated that more than 4 500 lives were saved across five SA cities from 2001 to 2005.[5] Pro-gun interest groups seeking to promote gun ownership and diffusion have attacked these findings, suggesting that stricter gun control was only enacted in 2004 following the publication of ...

  2. Gun Sales. Firearm Facts.

    Science.gov (United States)

    Duker, Laurie, Ed.

    Minimal federal regulations on firearm sales have facilitated the proliferation of guns, gun owners, and gun dealers in the United States. This fact sheet offers data on the growing number of firearm dealers, the relative ease of obtaining and keeping a license to sell guns from the Federal Bureau of Alcohol, Tobacco, and Firearms, the lack of…

  3. Nail gun injuries among construction workers.

    Science.gov (United States)

    Dement, John M; Lipscomb, Hester; Li, Leiming; Epling, Carol; Desai, Tejas

    2003-05-01

    Pneumatic nail guns greatly increase worker productivity and are extensively used in wood frame building construction, with especially high use in residential construction. One surveillance report of nail gun injuries in Washington State has been published; however, other literature consists largely of case reports and case series in trauma journals. The major objective of the current study was to investigate the occurrence of nail gun-associated injuries among construction workers and to identify preventable work-related factors associated with these injuries. Nail gun-related injuries occurring among a cohort of 13,347 carpenters in Ohio who worked union hours during the time period January 1, 1994, until September 30, 1997, were identified by matching the cohort with workers' compensation claims made to the Ohio Bureau of Workers' Compensation. We also analyzed workers' compensation claims for North Carolina Home Builders Association members for the period July 1996-November 1999 to identify nail gun-related injuries. Analyses included stratified analyses of claims by nature and body part injured, calculation of nail gun injury rates, and analyses of free text descriptions of injuries. Overall, nail gun injuries were responsible for 3.9 percent of workers' compensation claims with 8.3 percent to 25.5 percent of claims involving paid lost work time. The overall rate of nail gun injuries (cases per 200,000 work hours) was 0.33 in North Carolina and 0.26 in Ohio, reflecting the greater concentration of wood frame construction workers in the North Carolina population studied. Higher rates of injury were observed for carpenters in North Carolina and among residential carpenters in Ohio. The predominant body part injured was the hands/fingers, with 80 to 89 percent of injuries being nail punctures. Analyses of free text information for puncture injuries found approximately 70 percent of injuries to occur during the framing/sheathing stage of construction. Our data

  4. Combined effects of 1-methyl cyclopropene (1-MCP) and modified ...

    African Journals Online (AJOL)

    1-MCP-treated fruits delayed two different harvest maturity, persimmon fruits flesh firmness, and combination of 1-MCP with MAPA and MAPB reduced the ethylene production rate during storage. Treatment of 1-MCP improved storability of persimmon fruits more effectively than MAP storage. However, the results indicated ...

  5. TOF-SIMA analysis of coating on MCP

    International Nuclear Information System (INIS)

    Luo Chunping; Liang Handong; Sun Dongxu

    2007-01-01

    Microchannel plate (MCP) is a sophisticated electronic optical device. It has advantages of high gain, small size, and low using voltage as a detector. The electronic transmission film on the MCP input plane could effectively avoid the positive ion feedback, and protect the photocathode, eliminate flicker noise, and prolong the lifespan of the device. In conclusion, the different films of the input plane can affect the performance of the MCP. Therefore, there is practical value to study surface coating composition of MCP for understanding the relationship between composition and performance and developing high-powered MCP. In the experiment, TOF-SIMS is used to study the surface coating composition of MCP. The results show that there are some main metal elements such as Si, K, Cr, Ni, Rh, Cs and Pb in the surface of the MCP. (authors)

  6. ORELA electron guns

    International Nuclear Information System (INIS)

    Christian, O.W.; Lewis, T.A.

    1981-09-01

    The most recent information concerning the production and performance of ORELA electron guns is presented. Included are descriptions of procedures for gun fabrication, cathode conditioning and high voltage processing. Highlights of the performance characteristics are also included

  7. Electron gun for SSRF

    International Nuclear Information System (INIS)

    Sheng Shugang; Lin Guoqiang; Gu Qiang; Li Deming

    2003-01-01

    A 100 kV triode-electron-gun has been designed and manufactured for the Linac of Shanghai Synchrotron Radiation Facility (SSRF). In this paper the performance of the gun and some key components are described

  8. Guns and Violence. Current Controversies.

    Science.gov (United States)

    Kim, Henny H., Ed.

    This book focuses on gun violence and gun control, presenting both sides of arguments about firearms ownership and gun control. Each of five chapters poses a question about gun control and provides answers for both sides of the question. The following essays are included: (1) "Gun Violence Is Becoming an Epidemic" (Bob Herbert); (2) "Gun Violence…

  9. Ion feedback suppression using inclined MCP holes in a 'single-MCP+micromegas+pads' detector

    International Nuclear Information System (INIS)

    Va'vra, J.; Sumiyoshi, T.

    2005-01-01

    We show that the ion backflow to photocathode can be completely suppressed if one uses inclined MCP holes in the presence of a magnetic field. The inclined hole angles are chosen to be aligned with the Lorentz electron angle allowing the electron transmission and amplification, while positive ions, traveling along a different angle, are caught on the MCP hole walls. The detector under investigation is a new gaseous detector structure based on a tandem of two parts, a single MCP (microchannel plate), a micromegas with pad readout. We are aiming to develop a gaseous photon detector with the Bialkali photocathode, however, one could use some ideas in the paper for other types of detectors

  10. The Development of the Linac Coherent Light Source RF Gun

    International Nuclear Information System (INIS)

    Dowell, D

    2008-01-01

    The Linac Coherent Light Source (LCLS) is the first x-ray laser user facility based upon a free electron laser (FEL) requiring extraordinary beam quality to saturate at 1.5 angstroms within a 100 meter undulator.[1] This new type of light source is using the last kilometer of the three kilometer linac at SLAC to accelerate the beam to an energy as high as 13.6 GeV and required a new electron gun and injector to produce a very bright beam for acceleration. At the outset of the project it was recognized that existing RF guns had the potential to produce the desired beam but none had demonstrated it. Therefore a new RF gun or at least the modification of an existing gun was necessary. The parameters listed in Table 1 illustrate the unique characteristics of LCLS which drive the requirements for the electron gun as given in Table 2. The gun beam quality needs to accommodate emittance growth as the beam is travels through approximately one kilometer of linac and two bunch compressors before reaching the undulator. These beam requirements were demonstrated during the recent commissioning runs of the LCLS injector and linac [2] due to the successful design, fabrication, testing and operation of the LCLS gun. The goal of this paper is to relate the technical background of how the gun was able to achieve and in some cases exceed these requirements by understanding and correcting the deficiencies of the prototype s-band RF photocathode gun, the BNL/SLAC/UCLA Gun III. This paper begins with a brief history and technical description of Gun III and the Gun Test Facility (GTF) at SLAC, and studies of the gun's RF and emittance compensation solenoid. The work at the GTF identified the gun and solenoid deficiencies, and helped to define the specifications for the LCLS gun. Section 1.1.5 describes the modeling used to compute and correct the gun RF fields and Section 1.1.6 describes the use of these fields in the electron beam simulations. The magnetic design and measurements of

  11. Gun Theft and Crime.

    Science.gov (United States)

    Cook, Philip J

    2018-06-01

    Some law enforcement officials and other observers have asserted that theft is the primary source of guns to crime. In fact, the role of theft in supplying the guns used in robbery, assault, and murder is unknown, and current evidence provides little guidance about whether an effective program to reduce gun theft would reduce gun violence. The current article analyzes publicly available national data on gun theft together with a unique data set for Chicago. The results tend to support a conclusion that stolen guns play only a minor role in crime. First, publicly available data are used to calculate that thefts are only about 1% of all gun transactions nationwide. Second, an analysis of original data from Chicago demonstrates that less than 3% of crime guns recovered by the police have been reported stolen to the Chicago Police Department (CPD). If a gun is reported stolen, there is a 20% chance that it will be recovered, usually in conjunction with an arrest for illegal carrying. Less than half of those picked up with a stolen gun have a criminal record that includes violent offenses. Third, results from surveys of convicted criminals, both nationally and in Chicago, suggest that it is rare for respondents to have stolen the gun used in their most recent crime. The data on which these results are based have various shortcomings. A research agenda is proposed that would provide more certainty about the role of theft.

  12. Whose guns are stolen? The epidemiology of Gun theft victims.

    Science.gov (United States)

    Hemenway, David; Azrael, Deborah; Miller, Matthew

    2017-12-01

    Gun theft is an important source of guns used by criminals. Yet no empirical work has focused on the characteristics of gun owners that distinguish those who have had their guns stolen from those who have not. In this study, we examine the demographics and behavioral characteristics of gun owners who report having had a gun stolen. Data come from a nationally representative probability-based online survey conducted in April 2015, with a linked follow-up survey in November 2015 that asked gun owners about any theft of their guns in the past 5 years. Of 1,604 gun-owning respondents, 2.4% (95% CI 1.6,3.6) reported that one or more guns had been stolen, with a mean number of guns stolen per theft of 1.5 (95% CI 1.0,2.0]. Risk factors for having a gun stolen were owning 6 or more guns, owning guns for protection, carrying a gun in the past month, storing guns unsafely, and living in the South region of the United States. The South accounts for 37% of US households, 43% of gun owners, and two-thirds of all gun thefts. We estimate that there are approximately 250,000 gun theft incidents per year, with about 380,000 guns stolen. We find that certain types of gun owners-who own many guns, who carry guns, and who do not store guns safely-are at higher risk to have their guns stolen. Tracing data show that states in the South are exporters of crime guns used in other states. Our survey results find that the majority of guns stolen in the US come from the South.

  13. Single ion counting with a MCP (microchannel plate) detector

    Energy Technology Data Exchange (ETDEWEB)

    Tawara, Hiroko; Sasaki, Shinichi; Miyajima, Mitsuhiro [National Lab. for High Energy Physics, Tsukuba, Ibaraki (Japan); Shibamura, Eido

    1996-07-01

    In this study, a single-ion-counting method using alpha-particle-impact ionization of Ar atoms is demonstrated and the preliminary {epsilon}{sub mcp} for Ar ions with incident energies of 3 to 4.7 keV is determined. The single-ion counting by the MCP is aimed to be performed under experimental conditions as follows: (1) A signal from the MCP is reasonably identified as incidence of single Ar-ion. (2) The counting rate of Ar ions is less than 1 s{sup -1}. (3) The incident Ar ions are not focused on a small part of an active area of the MCP, namely, {epsilon}{sub mcp} is determined with respect to the whole active area of the MCP. So far, any absolute detection efficiency has not been reported under these conditions. (J.P.N.)

  14. Carbon Nanotube Electron Gun

    Science.gov (United States)

    Nguyen, Cattien V. (Inventor); Ribaya, Bryan P. (Inventor)

    2013-01-01

    An electron gun, an electron source for an electron gun, an extractor for an electron gun, and a respective method for producing the electron gun, the electron source and the extractor are disclosed. Embodiments provide an electron source utilizing a carbon nanotube (CNT) bonded to a substrate for increased stability, reliability, and durability. An extractor with an aperture in a conductive material is used to extract electrons from the electron source, where the aperture may substantially align with the CNT of the electron source when the extractor and electron source are mated to form the electron gun. The electron source and extractor may have alignment features for aligning the electron source and the extractor, thereby bringing the aperture and CNT into substantial alignment when assembled. The alignment features may provide and maintain this alignment during operation to improve the field emission characteristics and overall system stability of the electron gun.

  15. Carbon plasma gun

    International Nuclear Information System (INIS)

    Mendel, C.W. Jr.; Zagar, D.M.; Mills, G.S.; Humphries, S. Jr.; Goldstein, S.A.

    1980-01-01

    A family of plasma guns supplying highly ionized carbon plasma is described. The guns are simple and inexpensive to construct and are pulsed by small capacitor banks of a few hundred joules. The output consists of 10 17 --10 18 multiply ionized carbon ions traveling at about 10 7 cm/s. Neutral output is very low and arrives well after the ionized carbon. The guns and pulsers are very reliable

  16. CID thermionic gun system

    International Nuclear Information System (INIS)

    Koontz, R.F.

    1981-10-01

    A new high-current thermionic gun has been installed on the CID injector at SLAC and brought into operation. The gun and pulser system generate three nanosecond pulses of about six amps peak which, when bunched in the subharmonic buncher system, produce in excess of 10 11 electrons in a single S-band accelerated bunch. Preliminary operation of the gun is described, and details of the avalanche cathode drive pulser are presented

  17. CID thermionic gun system

    International Nuclear Information System (INIS)

    Koontz, R.F.

    1982-01-01

    A new high-current thermionic gun has been installed on the CID injector at SLAC and brought into operation. The gun and pulser system generate three nanosecond pulses of about six amps peak which, when bunched in the subharmonic buncher system, produce in excess of 10 11 electrons in a single S-band accelerated bunch. Preliminary operation of the gun is described, and details of the avalanche cathode drive pulser are presented

  18. Simplified pipe gun

    International Nuclear Information System (INIS)

    Sorensen, H.; Nordskov, A.; Sass, B.; Visler, T.

    1987-01-01

    A simplified version of a deuterium pellet gun based on the pipe gun principle is described. The pipe gun is made from a continuous tube of stainless steel and gas is fed in from the muzzle end only. It is indicated that the pellet length is determined by the temperature gradient along the barrel right outside the freezing cell. Velocities of around 1000 m/s with a scatter of +- 2% are obtained with a propellant gas pressure of 40 bar

  19. RF guns: a review

    International Nuclear Information System (INIS)

    Travier, C.

    1990-06-01

    Free Electron Lasers and future linear colliders require very bright electron beams. Conventional injectors made of DC guns and RF bunchers have intrinsic limitations. The recently proposed RF guns have already proven their capability to produce bright beams. The necessary effort to improve further these performances and to gain reliability is now undertaken by many laboratories. More than twenty RF gun projects both thermionic and laser-driven are reviewed. Their specific characteristics are outlined and their nominal performances are given

  20. High Brightness Injectors Based On Photocathode DC Gun

    International Nuclear Information System (INIS)

    B. Yunn

    2001-01-01

    Sample results of new injector design method based on a photocathode dc gun are presented, based on other work analytically proving the validity of the emittance compensation scheme for the case even when beam bunching is involved. We have designed several new injectors appropriate for different bunch charge ranges accordingly. Excellent beam quality produced by these injectors clearly shows that a photocathode dc gun can compete with a rf gun on an equal footing as the source of an electron beam for the bunch charge ranging up to 2 nano Coulomb (nC). This work therefore elevates a dc gun based injector to the preferred choice for many ongoing high brightness accelerator projects considering the proven operational stability and high average power capability of the dc gun

  1. Magnetized gun experiments

    International Nuclear Information System (INIS)

    Jarboe, T.R.; Henins, I.; Hoida, H.W.; Marshall, J.; Sherwood, A.R.

    1981-01-01

    In the Los Alamos Magnetized Gun Experiment we are attempting to produce a compact torus in a manner similar to an earlier experiment of Alfven. In our experiment a solenoidal coil is placed inside the inner electrode of a coaxial plasma gun. This coil produces an axial magnetic field inside the inner electrode which diverges and becomes a largely radial field in front of the gun muzzle. The idea is that when the gun is fired, the plasma escaping from the gun stretches these radial fields along the axial direction away from the gun, and these field lines can reconnect behind the plasma forming the poloidal field of the compact torus. The magnetic field generated by the gun current becomes the toroidal field and the major axis of the compact torus will be the same as the axis of the coaxial gun. Recent interest in this possible method of compact torus generation was stimulated by C. Hartman, and the approach is also being pursued in the field-reversed plasma gun experiment at LLL

  2. Electron guns for accelerators

    International Nuclear Information System (INIS)

    Rangarajan, L.M.; Mahadevan, S.; Ramamurthi, S.S.

    1995-01-01

    The high voltage, high current electron guns developed elsewhere for Linacs are based on cathode pulsing with direct emitting cathodes. Our grid pulsed triode gun employs indirect emitting cathode pellet under electron bombardment or a direct cathode emitter. Electron beam from the gun is injected to the accelerator guide at 40 kV and pulse duration is 2.8μsec. The gun is limited to axially symmetric geometry and electron optical design is optimized by computer programming. The gun with a water cooled Faraday cup is connected to a vacuum system comprising of a sputter ion pump and sorption pump. Working pressure is 1x10 -6 Pa. Gun is designed to be baked as an assembly at temperatures of 400 degC while vacuum processing. Materials are therefore restricted to refractory metals, SS, OFHC copper and all the electrodes are housed inside a ceramic tube. Lower Z graphite is used as a base material of Faraday cup. Grid is non-intercepting modulator anode, a new feature introduced, as compared to meshed grid system by others. CAT gun delivers 160 mA current pulses at 40 kV and its working characteristics such as perveance, emittance and beam radius compare well with SLAC and Hermosa guns. The above guns can be used for electron beam machines such as medical Linacs, industrial accelerators and EB welding equipment. (author). 2 refs., 2 figs

  3. Examination of the spatial-response uniformity of a microchannel-plate detector using a pulsed high-voltage electron gun

    International Nuclear Information System (INIS)

    Alumot, D; Kroupp, E; Fisher, A

    2014-01-01

    In this paper we describe an alternative method to examine the spatial-response uniformity of a microchannel-plate (MCP) detector to a ∼ 1 ns pulse of soft x-rays. The examination was performed by illuminating the MCP surface with energetic electrons rather than with x-rays. It is shown that the MCP features similar, yet not identical, response to pulses of soft x-ray photons or energetic electrons, making such examinations much simpler and less expensive. The building of the electron-gun system is relatively easy and inexpensive, and in addition to verifying the spatial uniformity of the response of the MCP to incoming particles and radiation, it can be used to detect damaged areas on the detector. A comparison between the results obtained using the electron-gun with those obtained using a laser-produced-plasma x-ray source, demonstrating the reliability of the method, is presented

  4. Systemic MCP1/CCR2 blockade and leukocyte specific MCP1/CCR2 inhibition affect aortic aneurysm formation differently

    NARCIS (Netherlands)

    de Waard, Vivian; Bot, Ilze; de Jager, Saskia C. A.; Talib, Sara; Egashira, Kensuke; de Vries, Margreet R.; Quax, Paul H. A.; Biessen, Erik A. L.; van Berkel, Theo J. C.

    2010-01-01

    Objective: CCR2, the receptor for monocyte chemoattractant protein 1 (MCP1), is involved in atherosclerosis and abdominal aortic aneurysms (AAAs). Here, we explored the potential beneficial blockade of the MCP1/CCR2 pathway. Methods: We applied an AAA model in aging apolipoprotein E deficient mice

  5. Gun Safety (For Parents)

    Science.gov (United States)

    ... from the home of a relative or friend. Teens should never be able to get to a gun and bullets without an adult being there. People of any age who are depressed are at increased risk of suicide. If someone in the family has depression, or has had thoughts of suicide, all guns ...

  6. Guns at College.

    Science.gov (United States)

    Miller, Matthew; Hemenway, David; Wechsler, Henry

    1999-01-01

    Surveyed undergraduate students nationwide concerning firearm possession. About 3.5% possessed working firearms. Students with guns were more likely to be male, White, or Native American; binge drink; live off-campus; and live with a spouse or significant other. Students with guns were more likely to engage in activities that put themselves and…

  7. Remotely controlled spray gun

    Science.gov (United States)

    Cunningham, William C. (Inventor)

    1987-01-01

    A remotely controlled spray gun is described in which a nozzle and orifice plate are held in precise axial alignment by an alignment member, which in turn is held in alignment with the general outlet of the spray gun by insert. By this arrangement, the precise repeatability of spray patterns is insured.

  8. Low Emittance Guns for the ILC Polarized Electron Beam

    International Nuclear Information System (INIS)

    Clendenin, J. E.; Brachmann, A.; Ioakeimidi, K.; Kirby, R. E.; Maruyama, T.; Miller, R. H.; Wang, J. W.; Zhou, F.

    2007-01-01

    Polarized electron beams generated by DC guns are routinely available at several accelerators including JLAB, Mainz and SLAC. These guns operate with a cathode bias on the order of -100 kV. To minimize space charge effects, relatively long bunches are generated at the gun and then compressed longitudinally external to the gun just before and during initial acceleration. For linear colliders, this compression is accomplished using a combination of rf bunchers. For the basic design of the International Linear Collider (ILC), a 120 kV DC photocathode gun is used to produce a series of nanosecond bunches that are each compressed by two sub-harmonic bunchers (SHBs) followed by an L-band buncher and capture section. The longitudinal bunching process results in a significantly higher emittance than produced by the gun alone. While high-energy experiments using polarized beams are not generally sensitive to the source emittance, there are several benefits to a lower source emittance including a simpler more efficient injector system and a lower radiation load during transport especially at bends as at the damping ring. For the ILC, the SHBs could be eliminated if the voltage of the gun is raised sufficiently. Simulations using the General Particle Tracer (GPT) package indicate that a cathode bias voltage of ≥200 kV should allow both SHBs to be operated at 433 or even 650 MHz, while ≥500 kV would be required to eliminate the SHBs altogether. Simulations can be used to determine the minimum emittance possible if the injector is designed for a given increased voltage. A possible alternative to the DC gun is an rf gun. Emittance compensation, routinely used with rf guns, is discussed for higher-voltage DC guns

  9. Low Emittance Guns for the ILC Polarized Electron Beam

    International Nuclear Information System (INIS)

    Clendenin, J.E.; Brachmann, A.; Ioakeimidi, K.; Kirby, R.E.; Maruyama, T.; Miller, R.H.; Wang, J.W.; Zhou, F.; SLAC

    2006-01-01

    Polarized electron beams generated by DC guns are routinely available at several accelerators including JLAB, Mainz and SLAC. These guns operate with a cathode bias on the order of -100 kV. To minimize space charge effects, relatively long bunches are generated at the gun and then compressed longitudinally external to the gun just before and during initial acceleration. For linear colliders, this compression is accomplished using a combination of rf bunchers. For the basic design of the International Linear Collider (ILC), a 120 kV DC photocathode gun is used to produce a series of nanosecond bunches that are each compressed by two sub-harmonic bunchers (SHBs) followed by an L-band buncher and capture section. The longitudinal bunching process results in a significantly higher emittance than produced by the gun alone. While high-energy experiments using polarized beams are not generally sensitive to the source emittance, there are several benefits to a lower source emittance including a simpler more efficient injector system and a lower radiation load during transport especially at bends as at the damping ring. For the ILC, the SHBs could be eliminated if the voltage of the gun is raised sufficiently. Simulations using the General Particle Tracer (GPT) package indicate that a cathode bias voltage of (ge)200 kV should allow both SHBs to be operated at 433 or even 650 MHz, while (ge)500 kV would be required to eliminate the SHBs altogether. Simulations can be used to determine the minimum emittance possible if the injector is designed for a given increased voltage. A possible alternative to the DC gun is an rf gun. Emittance compensation, routinely used with rf guns, is discussed for higher-voltage DC guns

  10. Optimization design of a 20-in. elliptical MCP-PMT

    International Nuclear Information System (INIS)

    Chen, Ping; Tian, Jinshou; Wei, Yonglin; Liu, Hulin; Sai, Xiaofeng; He, Jianping; Chen, Lin; Wang, Xing; Lu, Yu

    2017-01-01

    This paper describes the simulation work for optimizing the newly developed 20-in. elliptical MCP-PMT by enlarging the outside diameters of the two focusing electrodes and the open area of the glass bulb. Effects of biasing voltages applied to the two focusing electrodes and the MCP input facet are studied. With the new design of the 20 in. MCP-PMT, the transit time spread of the prototype can be less than 3 ns and the collection efficiency is as much as the present prototype.

  11. Efficiency enhancements for MCP-based beta autoradiography imaging

    CERN Document Server

    Lees, J E

    2002-01-01

    We describe three approaches to increase the beta detection efficiency of microchannel plate detectors for biological beta autoradiography:(a)reversing the microchannel plate (MCP) bias polarity, changing the conventional high negative voltage on the input MCP to a grounded input, (b) a reduction in MCP pore size from 12.5 to 6 mu m, (c) using a CsI coating as an efficient secondary electron emitter. We also present our first measurements of double-tracer ( sup 3 H and sup 1 sup 4 C) imaging using pulse height analysis to distinguish between isotopes.

  12. Effect of 1-methylcyclopropene (1- MCP) treatment on antioxidant ...

    African Journals Online (AJOL)

    ajl2

    2013-02-13

    Feb 13, 2013 ... of active oxygen-related metabolism of post-harvest Japanese apricot. The results ... a high content of vitamin C (ascorbic acid) and retarding the decrease ..... components analysis of the nfluence of 1-MCP and salicylic acid.

  13. Effects of Triptergium Glycosides on Expressions of MCP- 1 and ...

    African Journals Online (AJOL)

    the pathogenesis of diabetic nephropathy (DN), which is one of the chronic ..... the release of lysosomal enzymes and TGF, increase the ... important roles in the pathogenesis of this disease. Thus, MCP-1 and CTGF are potential targets for ...

  14. Lifetime of MCP-PMTs and other performance features

    Science.gov (United States)

    Lehmann, A.; Böhm, M.; Eyrich, W.; Miehling, D.; Pfaffinger, M.; Stelter, S.; Uhlig, F.; Ali, A.; Belias, A.; Dzhygadlo, R.; Gerhardt, A.; Götzen, K.; Kalicy, G.; Krebs, M.; Lehmann, D.; Nerling, F.; Patsyuk, M.; Peters, K.; Schepers, G.; Schmitt, L.; Schwarz, C.; Schwiening, J.; Traxler, M.; Düren, M.; Etzelmüller, E.; Föhl, K.; Hayrapetyan, A.; Kreutzfeld, K.; Merle, O.; Rieke, J.; Schmidt, M.; Wasem, T.; Achenbach, P.; Cardinali, M.; Hoek, M.; Lauth, W.; Schlimme, S.; Sfienti, C.; Thiel, M.

    2018-02-01

    The bar PANDA experiment at FAIR will use DIRC detectors for the separation of hadrons. The compactness of the bar PANDA detector requires the image planes of these detectors to be placed inside the magnetic field of the solenoid. Due to this and other boundary conditions MCP-PMTs were identified as the only suitable photon sensors. Until recently the major obstacle for an application of MCP-PMTs in high rate experiments like bar PANDA were serious aging problems which led to damage at the photo-cathode and a fast declining quantum efficiency as the integrated anode charge (IAC) increased. With new countermeasures against the aging, in particular due to the application of an atomic layer deposition (ALD) technique to coat the MCP pores, the lifetime of MCP-PMTs has meanwhile increased by a factor >50 which is fully sufficient for bar PANDA. The recent results of our long-term lifetime measurements are discussed. New 2-inch MCP-PMT prototypes from Hamamatsu show an encouraging behavior. However, the currently best performing MCP-PMT is a 2-inch PHOTONIS tube with two ALD-layers which reaches an IAC of >16 C/cm2 without any visible sign of aging. In the second part of these proceedings a new data acquisition system of the PADIWA/TRB type is presented which allows a quasi-parallel measurement of many MCP-PMT performance parameters. Especially unwanted effects like dark-count rate, crosstalk, ion after-pulsing, and recoil electrons can be studied in more detail than ever before. Exemplary results for these parameters are shown. The discussed DAQ system will be used for the comprehensive data quality checks of the MCP-PMTs being built into the DIRCs.

  15. High Velocity Gas Gun

    Science.gov (United States)

    1988-01-01

    A video tape related to orbital debris research is presented. The video tape covers the process of loading a High Velocity Gas Gun and firing it into a mounted metal plate. The process is then repeated in slow motion.

  16. Gun Dynamics Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — The Gun Dynamics Laboratory is a research multi-task facility, which includes two firing bays, a high bay area and a second floor laboratory space. The high bay area...

  17. Gun control saves lives.

    Science.gov (United States)

    Matzopoulos, Richard

    2016-05-19

    Reducing firearm mortality by means of stricter gun control is one of the most important short- to medium-term measures to address the burden of violence in South Africa, while longer-term interventions and policy measures take effect.

  18. Teen Suicide and Guns

    Science.gov (United States)

    ... Issues Listen Text Size Email Print Share Teen Suicide and Guns Page Content Article Body Protect Your ... of a passing problem, not the outcome! Teen Suicide—A Big Problem Suicide is one of the ...

  19. Single electron counting using a dual MCP assembly

    International Nuclear Information System (INIS)

    Yang, Yuzhen; Liu, Shulin; Zhao, Tianchi; Yan, Baojun; Wang, Peiliang; Yu, Yang; Lei, Xiangcui; Yang, Luping; Wen, Kaile; Qi, Ming

    2016-01-01

    The gain, pulse height resolution and peak-to-valley ratio of single electrons detected by using a Chevron configured Microchannel Plate (MCP) assembly are studied. The two MCPs are separated by a 280 µm gap and are biased by four electrodes. The purpose of the study is to determine the optimum bias voltage arrangements for single electron counting. By comparing the results of various bias voltage combinations, we conclude that good performance for the electron counting can be achieved by operating the MCP assembly in saturation mode. In addition, by applying a small reverse bias voltage across the gap while adjusting the bias voltages of the MCPs, optimum performance of electron counting can be obtained. - Highlights: • Dual MCPs assembly with four electrodes using different voltage combinations has been investigated for single electron counting. • Both the MCP voltages and the gap voltage can affect the gain, pulse height resolution and P/V ratio. • A high gain of the first stage MCP, a saturation mode of the second stage MCP and an appropriately reverse gap voltage can improve the resolution greatly. • The optimum voltage arrangements is significant for the design of MCP detectors in single electron counting applications.

  20. Gas gun dynamics

    International Nuclear Information System (INIS)

    Denny, Mark

    2013-01-01

    The mechanics and thermodynamics of one- and two-stage gas guns are developed. Very high projectile muzzle speed can be obtained by the two-stage version. The physics of simple gas guns, such as air rifles, is accessible to undergraduates and the same level of presentation is used here to understand more complex designs. Numerical solutions to the equations of motion are shown, along with insightful analytic approximations. (paper)

  1. Design and fabrication of a pulsed diode electron gun

    International Nuclear Information System (INIS)

    Mahadevan, S.; Gandhi, M.L.; Nandedkar, R.V.

    2003-01-01

    A pulsed diode electron gun has been designed, fabricated and tested and this will be used for the initial hot testing of the Plane Wave Transformer (PWT) linac. The gun is required to deliver 1 A at 70 kV which works out to a current of 500 mA at 40 kV. The gun geometry is optimized using the Electron Trajectory Program EGUN at a mesh size of 0.2 mm. The beam divergence close to cathode caused by an annular gap of 2 mm between cathode and focusing electrode (FE) is compensated by using a suitable focusing electrode. Important features of the pulsed power supply (40 kV, 500 mA, 2 μsec) developed for testing this gun are presented. The current measured at the Faraday cup is in agreement with the designed perveance. Suitable positioning of cathode with respect to the FE helps in further improving the beam quality

  2. CCL2/MCP-1 modulation of microglial activation and proliferation

    Directory of Open Access Journals (Sweden)

    Garcia-Bueno Borja

    2011-07-01

    Full Text Available Abstract Background Monocyte chemoattractant protein (CCL2/MCP-1 is a chemokine that attracts cells involved in the immune/inflammatory response. As microglia are one of the main cell types sustaining inflammation in brain, we proposed here to analyze the direct effects of MCP-1 on cultured primary microglia. Methods Primary microglia and neuronal cultures were obtained from neonatal and embryonic Wistar rats, respectively. Microglia were incubated with different concentrations of recombinant MCP-1 and LPS. Cell proliferation was quantified by measuring incorporation of bromodeoxyuridine (BrdU. Nitrite accumulation was measured using the Griess assay. The expression and synthesis of different proteins was measured by RT-PCR and ELISA. Cell death was quantified by measuring release of LDH into the culture medium. Results MCP-1 treatment (50 ng/ml, 24 h did not induce morphological changes in microglial cultures. Protein and mRNA levels of different cytokines were measured, showing that MCP-1 was not able to induce proinflammatory cytokines (IL-1β, IL6, MIP-1α, either by itself or in combination with LPS. A similar lack of effect was observed when measuring inducible nitric oxide synthase (NOS2 expression or accumulation of nitrites in the culture media as a different indicator of microglial activation. MCP-1 was also unable to alter the expression of different trophic factors that were reduced by LPS treatment. In order to explore the possible release of other products by microglia and their potential neurotoxicity, neurons were co-cultured with microglia: no death of neurons could be detected when treated with MCP-1. However, the presence of MCP-1 induced proliferation of microglia, an effect opposite to that observed with LPS. Conclusion These data indicate that, while causing migration and proliferation of microglia, MCP-1 does not appear to directly activate an inflammatory response in this cell type, and therefore, other factors may be

  3. Study on MCP-1 related to inflammation induced by biomaterials

    International Nuclear Information System (INIS)

    Ding Tingting; Sun Jiao; Zhang Ping

    2009-01-01

    The study of inflammation is important for understanding the reaction between biomaterials and the human body, in particular, the interaction between biomaterials and immune system. In the current study, rat macrophages were induced by multiple biomaterials with different biocompatibilities, including polyvinyl chloride (PVC) containing 8% of organic tin, a positive control material with cellular toxicity. Human umbilical vein endothelial cells (ECV-304), cultured with PRMI-1640, were detached from cells cultured with the supernatant of macrophages containing TNF-α and IL-1β because of stimulation by biomaterials. The cells were then treated with different biomaterials. Then both TNF-α and IL-1β in macrophages were detected by ELISA. Levels of monocyte chemoattractant protein-1 (MCP-1) were measured by RT-PCR. The results suggested that the expression of TNF-α and IL-1β was elevated by polytetrafluoroethylene (PTFE), polylactic-co-glycolic acid (PLGA) and American NPG alloy (p < 0.001). The level of MCP-1 cultured in supernatant of macrophages was higher than in PRMI-1640 with the same biomaterials. And the exposure to PTFE, PLGA and NPG resulted in the high expression of MCP-1 (p < 0.001) following cytokine stimulation. MCP-1 was also significantly expressed in β-tricalcium phosphate (β-TCP) and calcium phosphate cement samples (CPC) (p < 0.01). Thus, TNF-α, IL-1β and MCP-1 had played an important role in the immune reaction induced by biomaterials and there was a close relationship between the expression of cytokines and biomcompatibility of biomaterials. Furthermore, these data suggested that MCP-1 was regulated by TNF-α and IL-1β, and activated by both cytokines and biomaterials. The data further suggested that the expression of MCP-1 could be used as a marker to indicate the degree of immune reaction induced by biomaterials.

  4. Electromagnetic Guns versus Conventional Guns - a performance comparison

    NARCIS (Netherlands)

    Reus, N.M. de; Weijden, J. van der

    1993-01-01

    Performance improvement is one of the key issues of Electromagnetic gun systems compared to conventional gun systems. Due to higher muzzle velocities, the gun's fire control computer will be able to predict the target's future position more accurately because prediction time will be smaller. In this

  5. Fueling by coaxial plasma guns

    International Nuclear Information System (INIS)

    Marshall, J.

    1978-01-01

    The operating principles of pulsed coaxial guns are reviewed. Some problems involved with the injection of plasma beams from these guns into containment fields are described. The injection during reactor operating conditions is then discussed

  6. PHERMEX electron gun development

    International Nuclear Information System (INIS)

    Builta, L.A.; Elliott, J.C.; Moir, D.C.; Starke, T.P.; Vecere, C.A.

    1983-01-01

    The PHERMEX facility is a 50-MHz standing-wave linear accelerator. Electrons are injected, accelerated, and transported to a tungsten target where bremsstrahlung x rays are generated for flash radiography of hydrodynamic systems. The purpose of this article is to describe the progress of PHERMEX electron gun development. The goal of this program is to generate and transport a 200-ns, 1-MV, 1-kA electron beam into the first PHERMEX accelerating cavity. The standard gun is operated at a pulse voltage of 550 kV, which is the limit determined by internal breakdown of the vacuum insulator. This insulator has been redesigned, and the gun has been pulsed at 750 kV without internal breakdown. At present, the current output is not limited by voltage but by a phenomenon called pulse shortening, which occurs at a pulse voltage of approximately 650 kV. The phenomenon has been investigated and the results are presented

  7. Ion plasma electron gun

    International Nuclear Information System (INIS)

    Wakalopulos, G.

    1976-01-01

    In the disclosed electron gun positive ions generated by a hollow cathode plasma discharge in a first chamber are accelerated through control and shield grids into a second chamber containing a high voltage cold cathode. These positive ions bombard a surface of the cathode causing the cathode to emit secondary electrons which form an electron beam having a distribution adjacent to the cathode emissive surface substantially the same as the distribution of the ion beam impinging upon the cathode. After passing through the grids and the plasma discharge chamber, the electron beam exits from the electron gun via a foil window. Control of the generated electron beam is achieved by applying a relatively low control voltage between the control grid and the electron gun housing (which resides at ground potential) to control the density of the positive ions bombarding the cathode

  8. Unbalanced field RF electron gun

    Science.gov (United States)

    Hofler, Alicia

    2013-11-12

    A design for an RF electron gun having a gun cavity utilizing an unbalanced electric field arrangement. Essentially, the electric field in the first (partial) cell has higher field strength than the electric field in the second (full) cell of the electron gun. The accompanying method discloses the use of the unbalanced field arrangement in the operation of an RF electron gun in order to accelerate an electron beam.

  9. Glue Guns: Aiming for Safety

    Science.gov (United States)

    Roy, Ken

    2010-01-01

    While glue guns are very useful, there are safety issues. Regardless of the temperature setting, glue guns can burn skin. The teacher should demonstrate and supervise the use of glue guns and have a plan should a student get burned. There should be an initial first aid protocol in place, followed by a visit to the school nurse. An accident report…

  10. Low emittance thermionic electron guns

    International Nuclear Information System (INIS)

    Herrmannsfeldt, W.B.

    1989-01-01

    The author discusses self-field effects and external field effects for electron guns. He also discusses designs of electron guns and their uses in electron cooling systems and as an injector for electrostatic free electron lasers. He closes by looking at electron guns for linear accelerators. 20 references, 3 figures

  11. MCP1 haplotypes associated with protection from pulmonary tuberculosis

    Directory of Open Access Journals (Sweden)

    Owusu-Dabo Ellis

    2011-04-01

    Full Text Available Abstract Background The monocyte chemoattractant protein 1 (MCP-1 is involved in the recruitment of lymphocytes and monocytes and their migration to sites of injury and cellular immune reactions. In a Ghanaian tuberculosis (TB case-control study group, associations of the MCP1 -362C and the MCP1 -2581G alleles with resistance to TB were recently described. The latter association was in contrast to genetic effects previously described in study groups originating from Mexico, Korea, Peru and Zambia. This inconsistency prompted us to further investigate the MCP1 gene in order to determine causal variants or haplotypes genetically and functionally. Results A 14 base-pair deletion in the first MCP1 intron, int1del554-567, was strongly associated with protection against pulmonary TB (OR = 0.84, CI 0.77-0.92, Pcorrected = 0.00098. Compared to the wildtype combination, a haplotype comprising the -2581G and -362C promoter variants and the intronic deletion conferred an even stronger protection than did the -362C variant alone (OR = 0.78, CI 0.69-0.87, Pnominal = 0.00002; adjusted Pglobal = 0.0028. In a luciferase reporter gene assay, a significant reduction of luciferase gene expression was observed in the two constructs carrying the MCP1 mutations -2581 A or G plus the combination -362C and int1del554-567 compared to the wildtype haplotype (P = 0.02 and P = 0.006. The associated variants, in particular the haplotypes composed of these latter variants, result in decreased MCP-1 expression and a decreased risk of pulmonary TB. Conclusions In addition to the results of the previous study of the Ghanaian TB case-control sample, we have now identified the haplotype combination -2581G/-362C/int1del554-567 that mediates considerably stronger protection than does the MCP1 -362C allele alone (OR = 0.78, CI 0.69-0.87 vs OR = 0.83, CI 0.76-0.91. Our findings in both the genetic analysis and the reporter gene study further indicate a largely negligible role of the

  12. Guns, Germs and Steel

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 6; Issue 1. Guns, Germs and Steel - A Short History of Everybody for the Last 13,000 years. Suri Venkatachalam. Book Review Volume 6 Issue 1 January 2001 pp 84-88. Fulltext. Click here to view fulltext PDF. Permanent link:

  13. 120 Hz Gun Review

    Energy Technology Data Exchange (ETDEWEB)

    Colby, E.

    2005-01-31

    The review was held at SLAC on September 11 and 12, 2001. Presentations concerning the thermal analysis, mechanical design, integration with the laser and accelerator, general beam dynamics considerations, a load lock mechanism, and symmetric power feed options comprised the review. Slides from these presentations are available elsewhere. The review committee was charged with evaluating the 120 Hz gun design including proposed load lock and power feed options and recommending improvements. Broader evaluation of the injector as a whole (including focusing and diagnostic systems that do no impact the envelope of the gun itself) is expected to be covered in a future review and will not be commented on here. In general, the long operational experience with four generations of s-band RF guns at numerous labs worldwide has led to considerable experience in design, fabrication, and operation aspects, and provides an excellent base on which to design the higher duty factor LCLS injector. While open questions remain on obtaining the design performance from these injectors, the microwave design of the gun has reached a state of relative maturity.

  14. Gun Dealers, USA.

    Science.gov (United States)

    Duker, Laurie; And Others

    In the United States, more than 11,500 adolescents' and young adults' lives are taken each year by firearms. Although Federal law prohibits minors from purchasing handguns, they typically get them by asking someone of legal age (18 years or older) to purchase them from one of the 256,771 Federally licensed gun dealers. This pamphlet answers…

  15. Magnetron injection gun scaling

    International Nuclear Information System (INIS)

    Lawson, W.

    1988-01-01

    Existing analytic design equations for magnetron injection guns (MIG's) are approximated to obtain a set of scaling laws. The constraints are chosen to examine the maximum peak power capabilities of MIG's. The scaling laws are compared with exact solutions of the design equations and are supported by MIG simulations

  16. Quality management of cut carnation 'Tempo' with 1- MCP

    African Journals Online (AJOL)

    STORAGESEVER

    2009-10-19

    Oct 19, 2009 ... carnation 'Tempo' which is an ethylene-sensitive flower, were evaluated. The effects of 1-MCP .... rolling of the petals. Water uptake rate (ml g-1 .... The studies of Chamani (2006) on Rosa 'First red' cut flowers revealed that ...

  17. Quality management of cut carnation 'Tempo' with 1- MCP | Abadi ...

    African Journals Online (AJOL)

    Quality management of cut carnation 'Tempo' with 1- MCP. ... African Journal of Biotechnology ... time durations (3, 6 and 9 h) on the vaselife, water uptake, loss of fresh weight and chlorophyll index of cut carnation 'Tempo' which is an ...

  18. Practical XHV electron gun

    International Nuclear Information System (INIS)

    Urata, Tomohiro; Ishikawa, Tsuyoshi; Cho, Boklae; Oshima, Chuhei

    2008-01-01

    We have developed practical XHV chambers of a electron gun, of which the operating pressures are 1x10 -9 Pa in a stainless-steel one and 4x10 -9 Pa in a permalloy one. By mounting a noble single-atom electron source with high brightness and high spatial coherence on the electron gun including electron optics, we demonstrated highly collimated electron-beam emission: ∼80% of the total emission current entered the electron optics. This ratio was two or three orders of magnitude higher than those of the conventional electron sources. In XHV, in addition, we confirmed stable electron emission up to 20 nA, which results in the specimen current high enough for scanning electron microscopes. (author)

  19. Prospects for deflagration guns

    International Nuclear Information System (INIS)

    Cheng, D.Y.; Tripathi, P.P.; Chang, C.N.

    1978-01-01

    Deflagration is a process of fluid expansion with energy addition. Its existence in plasma physics was first discovered in the back-strapped T-tube experiments. In the coaxial plasma gun configuration the operation can be simple and yet produce a clean, high density (5 x 10 15 cm -3 ), and high kinetic energy (10 to 50 keV) collimated plasma beam. Plasma acceleration mechanism was thought to be driven by J x B force. Tapered electrodes have been used to obtain plasma beams. Scaling of the gun can be performed according to simple theory based on momentum and energy balance. Proposed plasma fueling and injection to magnetic fusion systems will be discussed

  20. RF Gun Optimization Study

    International Nuclear Information System (INIS)

    Alicia Hofler; Pavel Evtushenko

    2007-01-01

    Injector gun design is an iterative process where the designer optimizes a few nonlinearly interdependent beam parameters to achieve the required beam quality for a particle accelerator. Few tools exist to automate the optimization process and thoroughly explore the parameter space. The challenging beam requirements of new accelerator applications such as light sources and electron cooling devices drive the development of RF and SRF photo injectors. A genetic algorithm (GA) has been successfully used to optimize DC photo injector designs at Cornell University [1] and Jefferson Lab [2]. We propose to apply GA techniques to the design of RF and SRF gun injectors. In this paper, we report on the initial phase of the study where we model and optimize a system that has been benchmarked with beam measurements and simulation

  1. A pulsed electron gun for the Plane Wave Transformer Linac

    Science.gov (United States)

    Mahadevan, S.; Gandhi, M. L.; Nandedkar, R. V.

    2003-01-01

    A pulsed diode electron gun delivering 500 mA current at 40 kV is described. The gun geometry is optimized using the Electron Trajectory Program EGUN at higher scaling factors by choosing the closest converging starting surface. The effect of an annular gap between cathode and focusing electrode on beam behaviour is compensated by using a suitable focusing electrode. The estimated perveance is 0.065 μperv and the normalized emittance is within 5 π mm mrad. The variation in current density at the cathode has been limited to within 10% across the face of the cathode. Salient features of the pulsed power supply and an insight of its interconnection with the gun are presented. The current measured at the Faraday cup is in agreement with the designed perveance.

  2. A pulsed electron gun for the Plane Wave Transformer Linac

    Energy Technology Data Exchange (ETDEWEB)

    Mahadevan, S. E-mail: maharaja@cat.ernet.in; Gandhi, M.L. E-mail: mlg@cat.ernet.in; Nandedkar, R.V. E-mail: nrv@cat.ernet.in

    2003-01-01

    A pulsed diode electron gun delivering 500 mA current at 40 kV is described. The gun geometry is optimized using the Electron Trajectory Program EGUN at higher scaling factors by choosing the closest converging starting surface. The effect of an annular gap between cathode and focusing electrode on beam behaviour is compensated by using a suitable focusing electrode. The estimated perveance is 0.065 {mu}perv and the normalized emittance is within 5{pi} mm mrad. The variation in current density at the cathode has been limited to within 10% across the face of the cathode. Salient features of the pulsed power supply and an insight of its interconnection with the gun are presented. The current measured at the Faraday cup is in agreement with the designed perveance.

  3. A pulsed electron gun for the Plane Wave Transformer Linac

    CERN Document Server

    Mahadevan, S; Nandedkar, R V

    2003-01-01

    A pulsed diode electron gun delivering 500 mA current at 40 kV is described. The gun geometry is optimized using the Electron Trajectory Program EGUN at higher scaling factors by choosing the closest converging starting surface. The effect of an annular gap between cathode and focusing electrode on beam behaviour is compensated by using a suitable focusing electrode. The estimated perveance is 0.065 mu perv and the normalized emittance is within 5 pi mm mrad. The variation in current density at the cathode has been limited to within 10% across the face of the cathode. Salient features of the pulsed power supply and an insight of its interconnection with the gun are presented. The current measured at the Faraday cup is in agreement with the designed perveance.

  4. A pulsed electron gun for the Plane Wave Transformer Linac

    International Nuclear Information System (INIS)

    Mahadevan, S.; Gandhi, M.L.; Nandedkar, R.V.

    2003-01-01

    A pulsed diode electron gun delivering 500 mA current at 40 kV is described. The gun geometry is optimized using the Electron Trajectory Program EGUN at higher scaling factors by choosing the closest converging starting surface. The effect of an annular gap between cathode and focusing electrode on beam behaviour is compensated by using a suitable focusing electrode. The estimated perveance is 0.065 μperv and the normalized emittance is within 5π mm mrad. The variation in current density at the cathode has been limited to within 10% across the face of the cathode. Salient features of the pulsed power supply and an insight of its interconnection with the gun are presented. The current measured at the Faraday cup is in agreement with the designed perveance

  5. Mole gun injury.

    Science.gov (United States)

    Pistré, V; Rezzouk, J

    2013-09-01

    A mole gun is a weapon, which is used to trap and kill moles. This report provides an overview of the state of knowledge of mole gun injuries, comparable to blast injuries caused by fireworks, explosive or gunshot. Over a 2-year period, the authors reported their experience with ten hand injuries caused by mole gun. Radial side of the hand was often concerned, particularly the thumb. The authors explain their choices in the management of such lesions. Surgery was performed primarily and a large debridement currently seemed to offer the best outcome for the patient. Blast, crush, burns and lacerations may explain the higher rate of amputation to the digits. A long period of physiotherapy, specifically of the hand, was needed before the patient could return to work. This ballistic hand trauma encountered by surgeons requires knowledge and understanding of these injuries. It should be in accordance with firearms law because of severe injuries encountered and possible lethal wounds. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  6. Middle Ground on Gun Control

    Science.gov (United States)

    2016-12-01

    34 Australian Institute of Criminology, July 7, 2015, http://www.aic.gov.au/ statistics /homicide/weapon.html. 0 100 200 300 400 500 600 700 Total Gun...firearms is not the business of a single Australian , so it is immeasurably easier for politicians to categorically ban types of guns because there is...not an Australian version of Smith and Wesson that is going to be put out of business . Additionally, because all of the guns in Australia are

  7. Thermal characterization of indirectly heated axi-symmetric solid cathode electron beam gun for melting application

    International Nuclear Information System (INIS)

    Prakash, B.; Gupta, S.; Malik, P.; Mishra, K.K.; Jha, M.N.; Kandaswamy, E.; Martin, M.

    2015-01-01

    Electron beam melting gun with indirectly heated axi-symmetric solid cathode was designed, fabricated and characterized experimentally. The thermal simulation and optical analysis of the electron gun was carried out to estimate the power required to achieve the emission temperature of the solid cathode, to obtain the temperature distribution in the assembly and the beam transportation. On the basis of the thermal simulation and electron optics, the electron gun design was finalised. The electron gun assembly was fabricated and installed in the vacuum chamber for carrying out the experiment to find the actual temperature distribution. Thermocouple and two colour pyrometer were used to measure the temperature at various locations in the electron gun. The attenuation effect of the viewing port glass of the vacuum chamber was compensated in the final reading of the temperature measured by the pyrometer. The temperature of solid cathode obtained by the experiment was found to be 2800K which is the emission temperature of solid cathode. (author)

  8. Low emittance electron beam formation with a 17 GHz RF gun

    Directory of Open Access Journals (Sweden)

    W. J. Brown

    2001-08-01

    Full Text Available We report on electron beam quality measurement results from the Massachusetts Institute of Technology 17 GHz RF gun experiment. The 1.5 cell RF gun uses a solenoid for emittance compensation. It has produced bunch charges up to 0.1 nC with beam energies up to 1 MeV. The normalized rms emittance of the beam after 35 cm of transport from the gun has been measured by a slit technique to be 3π mm mrad for a 50 pC bunch. This agrees well with PARMELA simulations at these beam energies. At the exit of the electron gun, we estimate the emittance to be about 1π mm mrad, which corresponds to a beam brightness of about 80 A/(π mm mrad^{2}. Improved beam quality should be possible with a higher energy output electron beam from the gun.

  9. The ALS gun electronics system

    International Nuclear Information System (INIS)

    Lo, C.C.

    1993-01-01

    The ALS Gun Electronics system has been designed to accommodate the gun with a custom made socket and a high speed electronics circuit which is capable of producing single and multiple electron bunches with time jitters measured at better than 50 PS. The system generates the gated RF signal at ground level before sending it up to the 120 KV-biased gun deck via a fiber optic cable. The current pulse width as a function of grid bias, using an Eimac 8847A planar triode simulating an electron gun, was measured to show the relationship between the two parameters

  10. The ALS Gun Electronics system

    International Nuclear Information System (INIS)

    Lo, C.C.

    1993-05-01

    The ALS Gun Electronics system has been designed to accommodate gun with a custom made socket and high speed electronics circuit which is capable of producing single and multiple electron bunches with time jitters measured at better than 50 PS. The system generates the gated RF signal at ground level before sending it up to the 120 KV-biased gun deck via a fiber optic cable. The current pulse width as a function of grid bias, using an Eimac 8847A planar triode simulating an electron gun, was measured to show the relationship between the two parameters

  11. VIDA COMERCIAL DE PITAHAYA AMARILLA TRATADA CON 1-MCP

    Directory of Open Access Journals (Sweden)

    LILIANA SERNA-COCK

    Full Text Available 1-metilciclopropeno (1-MCP, un inhibidor del etileno, ha sido utilizado para extender la vida comercial de diferentes frutas. El objetivo de este trabajo fue evaluar el efecto de la aplicación de soluciones acuosas de 10, 100 y 200 gL-1 de 1-MCP, con tiempos de exposición de 1, 5 y 10 minutos, sobre la vida comercial de pitahaya amarilla en estado de madurez 4. Durante 15 días de almacenamiento (25 ± 2°C y 75% de humedad relativa, se evaluaron cambios físicos como la pérdida de peso y la aparición de pardeamiento; y se midieron cambios químicos como sólidos solubles, pH, acidez e índice de madurez. Se presentaron diferencias significativas entre los tratamientos. Los resultados demostraron que aplicaciones de 200 gL-1 de 1-MCP durante 10 minutos prolongó por tres días, la vida comercial de la pitahaya amarilla, y redujo cambios en los sólidos solubles y la acidez

  12. Understanding and Predicting Gun Barrel Erosion

    National Research Council Canada - National Science Library

    Johnston, Ian A

    2005-01-01

    The Australian Defence Force will soon have to contend with gun barrel erosion issues arising from the use of new low-vulnerability gun propellants, the acquisition of new ammunition and gun systems...

  13. Creative compensation

    International Nuclear Information System (INIS)

    Coll, D.

    1994-01-01

    A discussion is presented of executive compensation in Canada's petroleum industry. Mandatory disclosure of executive compensation and benefits is regulated by the Ontario Securities Commission. Examination of the compensation packages of 80 oilpatch CEOs shows a clear difference in philosophy between large and small companies. Larger companies pay larger salaries, offer pension plans, and reward long-term loyalty. Within smaller companies, compensation tends to be linked with stock performance. Trends in compensation are to lower base salaries with more variables such as bonuses, cash incentives and gain-sharing programs. Increasing shareholder scrutiny is prompting more stringent guidelines on stock option plans. Some companies place performance conditions on stock vesting. Another option is to grant premium priced options to executives, to increase the gains required for the executive to post a profit. Other comapanies are granting stock options to their field personnel, or are granting stock to all employees. Directors are playing an increasing role in executive compensation. 4 tabs

  14. Photocathode guns for single pass X-ray FELs

    International Nuclear Information System (INIS)

    Palmer, D.T.

    1997-10-01

    The present state of the art in photoinjector designs will be presented in this review. The authors discuss both proposed and operational photoinjectors with operating frequencies from L-band (1.424 GHz) to X-band (11.424 GHz). Also a novel pulsed DC gun will be presented. All the RF photoinjector discussed here use an emittance compensation scheme to align the different slices of the electron beam to decrease the beams normalized rms emittance

  15. The MCP-4/MCP-1 ratio in plasma is a candidate circadian biomarker for chronic post-traumatic stress disorder

    Science.gov (United States)

    Dalgard, C; Eidelman, O; Jozwik, C; Olsen, C H; Srivastava, M; Biswas, R; Eudy, Y; Rothwell, S W; Mueller, G P; Yuan, P; Drevets, W C; Manji, H K; Vythlingam, M; Charney, D S; Neumeister, A; Ursano, R J; Jacobowitz, D M; Pollard, H B; Bonne, O

    2017-01-01

    Post-traumatic stress disorder (PTSD) is psychiatric disease, which can occur following exposure to traumatic events. PTSD may be acute or chronic, and can have a waxing and waning course of symptoms. It has been hypothesized that proinflammatory cytokines and chemokines in the cerebrospinal fluid (CSF) or plasma might be mediators of the psychophysiological mechanisms relating a history of trauma exposure to changes in behavior and mental health disorders, and medical morbidity. Here we test the cytokine/chemokine hypothesis for PTSD by examining levels of 17 classical cytokines and chemokines in CSF, sampled at 0900 hours, and in plasma sampled hourly for 24 h. The PTSD and healthy control patients are from the NIMH Chronic PTSD and healthy control cohort, initially described by Bonne et al. (2011), in which the PTSD patients have relatively low comorbidity for major depressive disorder (MDD), drug or alcohol use. We find that in plasma, but not CSF, the bivariate MCP4 (CCL13)/ MCP1(CCL2) ratio is ca. twofold elevated in PTSD patients compared with healthy controls. The MCP-4/MCP-1 ratio is invariant over circadian time, and is independent of gender, body mass index or the age at which the trauma was suffered. By contrast, MIP-1β is a candidate biomarker for PTSD only in females, whereas TARC is a candidate biomarker for PTSD only in males. It remains to be discovered whether these disease-specific differences in circadian expression for these specific immune signaling molecules are biomarkers, surrogates, or drivers for PTSD, or whether any of these analytes could contribute to therapy. PMID:28170001

  16. Development of MCP transient operation strategy for the SMART-P

    International Nuclear Information System (INIS)

    Yoo, S. E.; Choi, B. S.; Kang, H. O.; Yoon, J. H.; Ji, S. K.

    2003-01-01

    SMART-P MCP(Main Coolant Pump) transient operation strategies are developed. A Modular Modeling System (MMS) computer code is used for the evaluation of the developed operation strategies. In the SMART-P, normal operating modes are classified into MCP high speed(3600 rpm) mode and MCP low speed mode. Also, natural circulation mode is defined as a performance test case. MCP operation transients occur when changing modes from one to another, and system parameters(core power, system pressure, temperature) are having transients. These transients affect on system performance and, in some cases, limit system operation. In this study, MCP operation strategies are developed and obtained acceptable results

  17. Gas injected washer plasma gun

    International Nuclear Information System (INIS)

    Jain, K.K.; John, P.I.; Punithavelu, A.M.; Rao, P.P.

    1980-01-01

    A plasma gun similar in geometry to the washer plasma gun has been operated with gas injected externally. hydrogen, nitrogen and argon plasmas have been ionised and accelerated to velocities of the order of 10 7 mm s -1 and densities 10 11 mm -3 . Higher parameter range is possible with higher electrical input power. (author)

  18. Gun Concerns Personal for Duncan

    Science.gov (United States)

    McNeil, Michele

    2013-01-01

    As U.S. Secretary of Education Arne Duncan works with other Obama administration officials on policy responses to the shootings at a Connecticut elementary school, he brings a personal and professional history that has acquainted him with the impact of gun violence. As schools chief in Chicago from 2001 to 2008, he was affected by the gun deaths…

  19. Preventing gun injuries in children.

    Science.gov (United States)

    Crossen, Eric J; Lewis, Brenna; Hoffman, Benjamin D

    2015-02-01

    Firearms are involved in the injury and death of a large number of children each year from both intentional and unintentional causes. Gun ownership in homes with children is common, and pediatricians should incorporate evidence-based means to discuss firearms and protect children from gun-related injuries and violence. Safe storage of guns, including unloaded guns locked and stored separately from ammunition, can decrease risks to children, and effective tools are available that pediatricians can use in clinical settings to help decrease children's access to firearms. Furthermore, several community-based interventions led by pediatricians have effectively reduced firearm-related injury risks to children. Educational programs that focus on children's behavior around guns have not proven effective. © American Academy of Pediatrics, 2015. All rights reserved.

  20. Electric arc welding gun

    Science.gov (United States)

    Luttrell, Edward; Turner, Paul W.

    1978-01-01

    This invention relates to improved apparatus for arc welding an interior joint formed by intersecting tubular members. As an example, the invention is well suited for applications where many similar small-diameter vertical lines are to be welded to a long horizontal header. The improved apparatus includes an arc welding gun having a specially designed welding head which is not only very compact but also produces welds that are essentially free from rolled-over solidified metal. The welding head consists of the upper end of the barrel and a reversely extending electrode holder, or tip, which defines an acute angle with the barrel. As used in the above-mentioned example, the gun is positioned to extend upwardly through the vertical member and the joint to be welded, with its welding head disposed within the horizontal header. Depending on the design of the welding head, the barrel then is either rotated or revolved about the axis of the vertical member to cause the electrode to track the joint.

  1. Losses compensation; Compensation des pertes

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    One mission of RTE (Electric Power Transportation), is to watch over the losses compensation resulting from the power transport on the electric power network. Since january 2001, RTE makes good the electric losses by the purchase of energy. To choose the marketers, a consultation has been realized by RTE. This document presents the rules concerning these losses compensation. (A.L.B.)

  2. Gun Shows and Gun Violence: Fatally Flawed Study Yields Misleading Results

    Science.gov (United States)

    Hemenway, David; Webster, Daniel; Pierce, Glenn; Braga, Anthony A.

    2010-01-01

    A widely publicized but unpublished study of the relationship between gun shows and gun violence is being cited in debates about the regulation of gun shows and gun commerce. We believe the study is fatally flawed. A working paper entitled “The Effect of Gun Shows on Gun-Related Deaths: Evidence from California and Texas” outlined this study, which found no association between gun shows and gun-related deaths. We believe the study reflects a limited understanding of gun shows and gun markets and is not statistically powered to detect even an implausibly large effect of gun shows on gun violence. In addition, the research contains serious ascertainment and classification errors, produces results that are sensitive to minor specification changes in key variables and in some cases have no face validity, and is contradicted by 1 of its own authors’ prior research. The study should not be used as evidence in formulating gun policy. PMID:20724672

  3. The Effects of Gun Ownership Rates and Gun Control Laws on Suicide Rates

    OpenAIRE

    Mark Gius

    2011-01-01

    The purpose of the present study is to determine the effects of gun control laws and gun ownership rates on state-level suicide rates. Using the most recent data on suicide rates, gun control measures, and gun ownership rates, the results of the present study suggest that states that require handgun permits have lower gun-related suicide rates, and states that have higher gun ownership rates have higher gun-related suicide rates. Regarding non-gun suicides, results suggest that stricter gun c...

  4. MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner

    International Nuclear Information System (INIS)

    Miyamoto, Kana; Ninomiya, Ken; Sonoda, Koh-Hei; Miyauchi, Yoshiteru; Hoshi, Hiroko; Iwasaki, Ryotaro; Miyamoto, Hiroya

    2009-01-01

    Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that plays a critical role in the recruitment and activation of leukocytes. Here, we describe that multinuclear osteoclast formation was significantly inhibited in cells derived from MCP-1-deficient mice. MCP-1 has been implicated in the regulation of osteoclast cell-cell fusion; however defects of multinuclear osteoclast formation in the cells from mice deficient in DC-STAMP, a seven transmembrane receptor essential for osteoclast cell-cell fusion, was not rescued by recombinant MCP-1. The lack of MCP-1 in osteoclasts resulted in a down-regulation of DC-STAMP, NFATc1, and cathepsin K, all of which were highly expressed in normal osteoclasts, suggesting that osteoclast differentiation was inhibited in MCP-1-deficient cells. MCP-1 alone did not induce osteoclastogenesis, however, the inhibition of osteoclastogenesis in MCP-1-deficient cells was restored by addition of recombinant MCP-1, indicating that osteoclastogenesis was regulated in an autocrine/paracrine manner by MCP-1 under the stimulation of RANKL in osteoclasts.

  5. Gun violence trends in movies.

    Science.gov (United States)

    Bushman, Brad J; Jamieson, Patrick E; Weitz, Ilana; Romer, Daniel

    2013-12-01

    Many scientific studies have shown that the mere presence of guns can increase aggression, an effect dubbed the "weapons effect." The current research examines a potential source of the weapons effect: guns depicted in top-selling films. Trained coders identified the presence of violence in each 5-minute film segment for one-half of the top 30 films since 1950 and the presence of guns in violent segments since 1985, the first full year the PG-13 rating (age 13+) was used. PG-13-rated films are among the top-selling films and are especially attractive to youth. Results found that violence in films has more than doubled since 1950, and gun violence in PG-13-rated films has more than tripled since 1985. When the PG-13 rating was introduced, these films contained about as much gun violence as G (general audiences) and PG (parental guidance suggested for young children) films. Since 2009, PG-13-rated films have contained as much or more violence as R-rated films (age 17+) films. Even if youth do not use guns, these findings suggest that they are exposed to increasing gun violence in top-selling films. By including guns in violent scenes, film producers may be strengthening the weapons effect and providing youth with scripts for using guns. These findings are concerning because many scientific studies have shown that violent films can increase aggression. Violent films are also now easily accessible to youth (e.g., on the Internet and cable). This research suggests that the presence of weapons in films might amplify the effects of violent films on aggression.

  6. Superconducting augmented rail gun (SARG)

    International Nuclear Information System (INIS)

    Homan, C.G.; Cummings, C.E.; Fowler, C.M.

    1986-01-01

    Superconducting augmentation consists of a superconducting coil operating in the persistent mode closely coupled magnetically with a normally conducting rail gun. A theoretical investigation of the effect of this system on a rail gun has shown that two benefits occur. Projectile velocities and launch efficiencies increase significantly depending on the magnetic coupling between the rail and augmentation circuits. Previous work evaluated an idealized system by neglecting energy dissipation effects. In this paper, the authors extend the analysis to include the neglected terms and show improved actual launch efficiencies for the SARG configuration. In this paper, the authors discuss details of projectile design in depth and present preliminary results of rail gun performance

  7. Plural beam electron gun assembly

    International Nuclear Information System (INIS)

    Stratton, M.G.

    1977-01-01

    The invention relates to a cathode ray tube plural-beam-in-line bi-potential electron gun assembly, having applied beam currents of differing levels, manifests structurally modified gun structures to effect focused beam landings at the screen that are evidenced as substantially equi-sized spots thereby providing improved resolution and brightness of the screen imagery. The structural changes embody modifications of the related focusing and accelerator electrodes of the respective guns to provide a partial telescoping arrangement for effecting the discrete placement, forming and shielding of the final focusing lenses. The three lenses so formed are in different planes in partial overlapping axial relationship

  8. Gun barrel erosion - Comparison of conventional and LOVA gun propellants

    NARCIS (Netherlands)

    Hordijk, A.C.; Leurs, O.

    2006-01-01

    The research department Energetic Materials within TNO Defence, Security and Safety is involved in the development and (safety and insensitive munitions) testing of conventional (nitro cellulose based) and thermoplastic elastomer (TPE) based gun propellants. Recently our testing capabilities have

  9. Modular Engine Noise Component Prediction System (MCP) Program Users' Guide

    Science.gov (United States)

    Golub, Robert A. (Technical Monitor); Herkes, William H.; Reed, David H.

    2004-01-01

    This is a user's manual for Modular Engine Noise Component Prediction System (MCP). This computer code allows the user to predict turbofan engine noise estimates. The program is based on an empirical procedure that has evolved over many years at The Boeing Company. The data used to develop the procedure include both full-scale engine data and small-scale model data, and include testing done by Boeing, by the engine manufacturers, and by NASA. In order to generate a noise estimate, the user specifies the appropriate engine properties (including both geometry and performance parameters), the microphone locations, the atmospheric conditions, and certain data processing options. The version of the program described here allows the user to predict three components: inlet-radiated fan noise, aft-radiated fan noise, and jet noise. MCP predicts one-third octave band noise levels over the frequency range of 50 to 10,000 Hertz. It also calculates overall sound pressure levels and certain subjective noise metrics (e.g., perceived noise levels).

  10. Creative compensation

    Energy Technology Data Exchange (ETDEWEB)

    Coll, D

    1994-09-19

    A discussion is presented of executive compensation in Canada's petroleum industry. Mandatory disclosure of executive compensation and benefits is regulated by the Ontario Securities Commission. Examination of the compensation packages of 80 oilpatch CEOs shows a clear difference in philosophy between large and small companies. Larger companies pay larger salaries, offer pension plans, and reward long-term loyalty. Within smaller companies, compensation tends to be linked with stock performance. Trends in compensation are to lower base salaries with more variables such as bonuses, cash incentives and gain-sharing programs. Increasing shareholder scrutiny is prompting more stringent guidelines on stock option plans. Some companies place performance conditions on stock vesting. Another option is to grant premium priced options to executives, to increase the gains required for the executive to post a profit. Other comapanies are granting stock options to their field personnel, or are granting stock to all employees. Directors are playing an increasing role in executive compensation. 4 tabs.

  11. Reverse Ballistic Air Gun Facility

    Data.gov (United States)

    Federal Laboratory Consortium — This custom-designed facility houses a suite of three air guns capable of generating accelerations up to 100,000 Gs and velocities up to 2,000 ft/s. In addition to a...

  12. Temporal association between federal gun laws and the diversion of guns to criminals in Milwaukee.

    Science.gov (United States)

    Webster, Daniel W; Vernick, Jon S; Bulzacchelli, Maria T; Vittes, Katherine A

    2012-02-01

    The practices of licensed gun dealers can threaten the safety of urban residents by facilitating the diversion of guns to criminals. In 2003, changes to federal law shielded gun dealers from the release of gun trace data and provided other protections to gun dealers. The 14-month period during which the dealer did not sell junk guns was associated with a 68% reduction in the diversion of guns to criminals within a year of sale by the dealer and a 43% increase in guns diverted to criminals following sales by other dealers. The laws were associated with a 203% increase in the number of guns diverted to criminals within a year of sale by the gun store, which was the focus of this study. Policies which affect gun dealer accountability appeared to influence the diversion of guns to criminals.

  13. Associations between Deceased-Donor Urine MCP-1 and Kidney Transplant Outcomes.

    Science.gov (United States)

    Mansour, S G; Puthumana, J; Reese, P P; Hall, I E; Doshi, M D; Weng, F L; Schröppel, B; Thiessen-Philbrook, H; Bimali, M; Parikh, C R

    2017-07-01

    Existing methods to predict recipient allograft function during deceased-donor kidney procurement are imprecise. Understanding the potential renal reparative role for monocyte chemoattractant protein-1 (MCP-1), a cytokine involved in macrophage recruitment after injury, might help predict allograft outcomes. We conducted a sub-study of the multicenter prospective Deceased Donor Study cohort, which evaluated deceased kidney donors from five organ procurement organizations from May 2010 to December 2013. We measured urine MCP-1 (uMCP-1) concentrations from donor samples collected at nephrectomy to determine associations with donor acute kidney injury (AKI), recipient delayed graft function (DGF), 6-month estimated GFR (eGFR), and graft failure. We also assessed perfusate MCP-1 concentrations from pumped kidneys for associations with DGF and 6-month eGFR. AKI occurred in 111 (9%) donors. Median (interquartile range) uMCP-1 concentration was higher in donors with AKI compared to donors without AKI (1.35 [0.41-3.93] ng/ml vs. 0.32 [0.11-0.80] ng/ml, p<0.001). DGF occurred in 756 (31%) recipients, but uMCP-1 was not independently associated with DGF. Higher donor uMCP-1 concentrations were independently associated with higher 6-month eGFR in those without DGF [0.77 (0.10, 1.45) ml/min/1.73m 2 per doubling of uMCP1]. However, there were no independent associations between uMCP-1 and graft failure over a median follow-up of about 2 years. Lastly, perfusate MCP-1 concentrations significantly increased during pump perfusion but were not associated with DGF or 6-month eGFR. Donor uMCP-1 concentrations were modestly associated with higher recipient 6-month eGFR in those without DGF. However, the results suggest that donor uMCP-1 has minimal clinical utility given no associations with graft failure.

  14. NASA-Ames vertical gun

    Science.gov (United States)

    Schultz, P. H.

    1984-01-01

    A national facility, the NASA-Ames vertical gun range (AVGR) has an excellent reputation for revealing fundamental aspects of impact cratering that provide important constraints for planetary processes. The current logistics in accessing the AVGR, some of the past and ongoing experimental programs and their relevance, and the future role of this facility in planetary studies are reviewed. Publications resulting from experiments with the gun (1979 to 1984) are listed as well as the researchers and subjects studied.

  15. State Gun Law Environment and Youth Gun Carrying in the United States.

    Science.gov (United States)

    Xuan, Ziming; Hemenway, David

    2015-11-01

    Gun violence and injuries pose a substantial threat to children and youth in the United States. Existing evidence points to the need for interventions and policies for keeping guns out of the hands of children and youth. (1) To examine the association between state gun law environment and youth gun carrying in the United States, and (2) to determine whether adult gun ownership mediates this association. This was a repeated cross-sectional observational study design with 3 years of data on youth gun carrying from US states. The Youth Risk Behavior Survey comprises data of representative samples of students in grades 9 to 12 from biennial years of 2007, 2009, and 2011. We hypothesized that states with more restrictive gun laws have lower rates of youth gun carrying, and this association is mediated by adult gun ownership. State gun law environment as measured by state gun law score. Youth gun carrying was defined as having carried a gun on at least 1 day during the 30 days before the survey. In the fully adjusted model, a 10-point increase in the state gun law score, which represented a more restrictive gun law environment, was associated with a 9% decrease in the odds of youth gun carrying (adjusted odds ratio [AOR], 0.91 [95% CI, 0.86-0.96]). Adult gun ownership mediated the association between state gun law score and youth gun carrying (AOR, 0.94 [ 95% CI, 0.86-1.01], with 29% attenuation of the regression coefficient from -0.09 to -0.07 based on bootstrap resampling). More restrictive overall gun control policies are associated with a reduced likelihood of youth gun carrying. These findings are relevant to gun policy debates about the critical importance of strengthening overall gun law environment to prevent youth gun carrying.

  16. State Gun Policy and Cross-State Externalities: Evidence from Crime Gun Tracing

    OpenAIRE

    Brian Knight

    2013-01-01

    This paper provides a theoretical and empirical analysis of cross-state externalities associated with gun regulations in the context of the gun trafficking market. Using gun tracing data, which identify the source state for crime guns recovered in destination states, we find that firearms in this market tend to flow from states with weak gun laws to states with strict gun laws, satisfying a necessary condition for the existence of cross-state externalities in the theoretical model. We also fi...

  17. A high-gradient high-duty-factor Rf photo-cathode electron gun

    International Nuclear Information System (INIS)

    Rimmer, Robert A.; Hartman, Neal; Lidia, Steven M.; Wang, Shaoheng

    2002-01-01

    We describe the analysis and preliminary design of a high-gradient, high-duty factor RF photocathode gun. The gun is designed to operate at high repetition rate or CW, with high gradient on the cathode surface to minimize emittance growth due to space charge forces at high bunch charge. The gun may also be operated in a solenoidal magnetic field for emittance compensation. The design is intended for use in short-pulse, high-charge, and high-repetition rate applications such as linac based X-ray sources. We present and compare the results of gun simulations using different codes, as well as RF and thermal analysis of the structure

  18. A high-gradient high-duty-factor RF photo-cathode electron gun

    International Nuclear Information System (INIS)

    Rimmer, Robert; Hartman, N.; Lidia, S.; Wang, S.H.

    2002-01-01

    We describe the analysis and preliminary design of a high-gradient, high-duty factor RF photocathode gun. The gun is designed to operate at high repetition rate or CW, with high gradient on the cathode surface to minimize emittance growth due to space charge forces at high bunch charge. The gun may also be operated in a solenoidal magnetic field for emittance compensation. The design is intended for use in short-pulse, high-charge, and high-repetition rate applications such as linac based X-ray sources. We present and compare the results of gun simulations using different codes, as well as RF and thermal analysis of the structure

  19. PEG-albumin plasma expansion increases expression of MCP-1 evidencing increased circulatory wall shear stress: an experimental study.

    Directory of Open Access Journals (Sweden)

    C Makena Hightower

    Full Text Available Treatment of blood loss with plasma expanders lowers blood viscosity, increasing cardiac output. However, increased flow velocity by conventional plasma expanders does not compensate for decreased viscosity in maintaining vessel wall shear stress (WSS, decreasing endothelial nitric oxide (NO production. A new type of plasma expander using polyethylene glycol conjugate albumin (PEG-Alb causes supra-perfusion when used in extreme hemodilution and is effective in treating hemorrhagic shock, although it is minimally viscogenic. An acute 40% hemodilution/exchange-transfusion protocol was used to compare 4% PEG-Alb to Ringer's lactate, Dextran 70 kDa and 6% Hetastarch (670 kDa in unanesthetized CD-1 mice. Serum cytokine analysis showed that PEG-Alb elevates monocyte chemotactic protein-1 (MCP-1, a member of a small inducible gene family, as well as expression of MIP-1α, and MIP-2. MCP-1 is specific to increased WSS. Given the direct link between increased WSS and production of NO, the beneficial resuscitation effects due to PEG-Alb plasma expansion appear to be due to increased WSS through increased perfusion and blood flow rather than blood viscosity.

  20. The case for moderate gun control.

    Science.gov (United States)

    DeGrazia, David

    2014-03-01

    In addressing the shape of appropriate gun policy, this essay assumes for the sake of discussion that there is a legal and moral right to private gun ownership. My thesis is that, against the background of this right, the most defensible policy approach in the United States would feature moderate gun control. The first section summarizes the American gun control status quo and characterizes what I call "moderate gun control." The next section states and rebuts six leading arguments against this general approach to gun policy. The section that follows presents a positive case for moderate gun control that emphasizes safety in the home and society as well as rights whose enforcement entails some limits or qualifications on the right to bear arms. A final section shows how the recommended gun regulations address legitimate purposes, rather than imposing arbitrary restrictions on gun rights, and offers concluding reflections.

  1. Results of the AFWL deflagration gun experiments

    International Nuclear Information System (INIS)

    Hackett, K.E.; Baker, W.L.; Beason, J.D.

    1987-01-01

    The snowplow and deflagration modes of coaxial plasma gun operation have been experimentally investigated and computationally simulated at the Air Force Weapons Laboratory. The snowplow mode occurs when the gun is prefilled to a uniform gas density. The initial breakdown forms near the insulator at the gun breech. It heats the gas and creates a shock wave that travels down the gun, ionizing gas and producing a thin current sheath that travels just behind the shock front. The shock front piles up the gas in front of itself as it moves down the gun - hence the name ''snowplow''. Deflagration occurs when gas is injected into an evacuated gun so that the initial breakdown forms as the gas fills the gun. The ionized gas is accelerated into the vacuum region carrying current and magnetic field with it. A quasi-stationary diffuse discharge develops. Gas still entering the gun is processed through the deflagrating discharge and accelerated out the gun muzzle

  2. Two micron pore size MCP-based image intensifiers

    Science.gov (United States)

    Glesener, John; Estrera, Joseph

    2010-02-01

    Image intensifiers (I2) have many advantages as detectors. They offer single photon sensitivity in an imaging format, they're light in weight and analog I2 systems can operate for hours on a single AA battery. Their light output is such as to exploit the peak in color sensitivity of the human eye. Until recent developments in CMOS sensors, they also were one of the highest resolution sensors available. The closest all solid state solution, the Texas Instruments Impactron chip, comes in a 1 megapixel format. Depending on the level of integration, an Impactron based system can consume 20 to 40 watts in a system configuration. In further investing in I2 technology, L-3 EOS determined that increasing I2 resolution merited a high priority. Increased I2 resolution offers the system user two desirable options: 1) increased detection and identification ranges while maintaining field-of-view (FOV) or 2) increasing FOV while maintaining the original system resolution. One of the areas where an investment in resolution is being made is in the microchannel plate (MCP). Incorporation of a 2 micron MCP into an image tube has the potential of increasing the system resolution of currently fielded systems. Both inverting and non-inverting configurations are being evaluated. Inverting tubes are being characterized in night vision goggle (NVG) and sights. The non-inverting 2 micron tube is being characterized for high resolution I2CMOS camera applications. Preliminary measurements show an increase in the MTF over a standard 5 micron pore size, 6 micron pitch plate. Current results will be presented.

  3. Large Bore Powder Gun Qualification (U)

    Energy Technology Data Exchange (ETDEWEB)

    Rabern, Donald A. [Los Alamos National Laboratory; Valdiviez, Robert [Los Alamos National Laboratory

    2012-04-02

    A Large Bore Powder Gun (LBPG) is being designed to enable experimentalists to characterize material behavior outside the capabilities of the NNSS JASPER and LANL TA-55 PF-4 guns. The combination of these three guns will create a capability to conduct impact experiments over a wide range of pressures and shock profiles. The Large Bore Powder Gun will be fielded at the Nevada National Security Site (NNSS) U1a Complex. The Complex is nearly 1000 ft below ground with dedicated drifts for testing, instrumentation, and post-shot entombment. To ensure the reliability, safety, and performance of the LBPG, a qualification plan has been established and documented here. Requirements for the LBPG have been established and documented in WE-14-TR-0065 U A, Large Bore Powder Gun Customer Requirements. The document includes the requirements for the physics experiments, the gun and confinement systems, and operations at NNSS. A detailed description of the requirements is established in that document and is referred to and quoted throughout this document. Two Gun and Confinement Systems will be fielded. The Prototype Gun will be used primarily to characterize the gun and confinement performance and be the primary platform for qualification actions. This gun will also be used to investigate and qualify target and diagnostic modifications through the life of the program (U1a.104 Drift). An identical gun, the Physics Gun, will be fielded for confirmatory and Pu experiments (U1a.102D Drift). Both guns will be qualified for operation. The Gun and Confinement System design will be qualified through analysis, inspection, and testing using the Prototype Gun for the majority of process. The Physics Gun will be qualified through inspection and a limited number of qualification tests to ensure performance and behavior equivalent to the Prototype gun. Figure 1.1 shows the partial configuration of U1a and the locations of the Prototype and Physics Gun/Confinement Systems.

  4. Lake Wobegon’s Guns: Overestimating Our Gun-Related Competences

    Directory of Open Access Journals (Sweden)

    Emily Stark

    2016-02-01

    Full Text Available The Lake Wobegon Effect is a general tendency for people to overestimate their own abilities. In this study, the authors conducted a large, nationally-representative survey of U.S. citizens to test whether Americans overestimate their own gun-relevant personality traits, gun safety knowledge, and ability to use a gun in an emergency. The authors also tested how gun control attitudes, political identification, gender, and gun experience affect self-perceptions. Consistent with prior research on the Lake Wobegon Effect, participants overestimated their gun-related competencies. Conservatives, males, and pro-gun advocates self-enhanced somewhat more than their counterparts but this effect was primarily due to increased gun experience among these participants. These findings are important to policymakers in the area of gun use, because overconfidence in one’s gun-related abilities may lead to a reduced perceived need for gun training.

  5. Heavy duty plasma spray gun

    International Nuclear Information System (INIS)

    Irons, G.C.; Klein, J.F.; Lander, R.D.; Thompson, H.C.; Trapani, R.D.

    1984-01-01

    A heavy duty plasma spray gun for extended industrial service is disclosed. The gun includes a gas distribution member made of a material having a coefficient of expansion different from that of the parts surrounding it. The gas distribution member is forcibly urged by a resilient member such as a coiled spring against a seal so as to assure the plasma gas is introduced into the gun arc in a manner only defined by the gas distribution member. The gun has liquid cooling for the nozzle (anode) and the cathode. Double seals are provided between the coolant and the arc region and a vent is provided between the seals which provides an indication when a seal has failed. Some parts of the gun are electrically isolated from others by an intermediate member which is formed as a sandwich of two rigid metal face pieces and an insulator disposed between them. The metal face pieces provide a rigid body to attach the remaining parts in proper alignment therewith

  6. The chemokine MCP-1 (CCL2) in the host interaction with cancer: a foe or ally?

    Science.gov (United States)

    Yoshimura, Teizo

    2018-01-29

    Macrophages are one of the most abundant leukocyte populations infiltrating tumor tissues and can exhibit both tumoricidal and tumor-promoting activities. In 1989, we reported the purification of monocyte chemoattractant protein-1 (MCP-1) from culture supernatants of mitogen-activated peripheral blood mononuclear cells and tumor cells. MCP-1 is a potent monocyte-attracting chemokine, identical to the previously described lymphocyte-derived chemotactic factor or tumor-derived chemotactic factor, and greatly contributes to the recruitment of blood monocytes into sites of inflammatory responses and tumors. Because in vitro-cultured tumor cells often produce significant amounts of MCP-1, tumor cells are considered to be the main source of MCP-1. However, various non-tumor cells in the tumor stroma also produce MCP-1 in response to stimuli. Studies performed in vitro and in vivo have provided evidence that MCP-1 production in tumors is a consequence of complex interactions between tumor cells and non-tumor cells and that both tumor cells and non-tumor cells contribute to the production of MCP-1. Although MCP-1 production was once considered to be a part of host defense against tumors, it is now believed to regulate the vicious cycle between tumor cells and macrophages that promotes the progression of tumors.Cellular and Molecular Immunology advance online publication, 29 January 2018; doi:10.1038/cmi.2017.135.

  7. Associations Between Deceased-Donor Urine MCP-1 and Kidney Transplant Outcomes

    Directory of Open Access Journals (Sweden)

    S.G. Mansour

    2017-07-01

    Discussion: Donor uMCP-1 concentrations were modestly associated with higher recipient 6-month eGFR in those without DGF. However, the results suggest that donor uMCP-1 has minimal clinical utility given no associations with graft failure.

  8. Circulating MCP-1 level and вˆј2518 gene polymorphism as a ...

    African Journals Online (AJOL)

    Azza M. Hassan

    that plays an important role in the recruitment of monocytes/macrophages into renal tubulointer- stitium. A biallelic A/G polymorphism at position 2518 in the MCP-1 gene was found ..... minurea, but also with UAE in their type 2 diabetic patients. This is explained by the pivotal role played by increased MCP-. 1 production due ...

  9. Monocyte chemoattractant protein 1 (MCP-1) in temporal arteritis and polymyalgia rheumatica

    DEFF Research Database (Denmark)

    Ellingsen, T; Elling, P; Olson, A

    2000-01-01

    was localised to the vessel wall in patients with TA. In TA, PMR, and healthy controls MCP-1 was quantified by enzyme linked immunosorbent assay (ELISA) in plasma. RESULTS: MCP-1 was localised to the majority of mononuclear cells, some smooth muscle cells, and giant cells in the arterial biopsy specimens from...

  10. Electron optics design of an 8-in. spherical MCP-PMT

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Ping, E-mail: chenping@opt.cn [Key Laboratory of Ultra-fast photoelectric Diagnostics Technology, Xi’an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences, Xi’an 710119 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan 030006, Shanxi (China); Tian, Jinshou [Key Laboratory of Ultra-fast photoelectric Diagnostics Technology, Xi’an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences, Xi’an 710119 (China); Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan 030006, Shanxi (China); Qian, Sen; Zhao, Tianchi [Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); Liu, Hulin; Wei, Yonglin; Sai, Xiaofeng; He, Jianping; Wang, Xing; Lu, Yu [Key Laboratory of Ultra-fast photoelectric Diagnostics Technology, Xi’an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences, Xi’an 710119 (China); Chen, Lin; Guo, Lehui; Pei, Chengquan; Hui, Dandan [Key Laboratory of Ultra-fast photoelectric Diagnostics Technology, Xi’an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences, Xi’an 710119 (China); University of Chinese Academy of Sciences, Beijing 100049 (China)

    2017-03-11

    This paper discusses the electron optical system of an 8-in. spherical MCP-PMT. The MCP assembly, the supporting pole and the supply voltages are carefully designed to optimize the photoelectron collection efficiency and the transit time spread. Coating the MCP nickel-chromium electrode with an additional high secondary emission material is employed to make a breakthrough on the collection efficiency. With the simulation software CST, the Finite Integration method and the Monte Carlo method are combined to evaluate the collection efficiency, the time properties and the Earth's magnetic field effects. Simulation results show that the photocathode active solid angle is over 3.5 πsr, the average collection efficiency can exceed 95% with the coated MCP and the mean transit time spread is 2.2 ns for a typical electric potential of 500 V applied between the photocathode and the MCP input facet. The prototype and the measured single photoelectron spectrum are also presented.

  11. Study of the effects of 1-MCP to blueberry under cold storage

    Science.gov (United States)

    Tao, Shenchen; Chu, Huailiang; Chen, Xiaomin; Yuan, Huwei; Qiu, Lingling; Zhao, Liang; Yan, Daoliang; Zheng, Bingsong

    2017-04-01

    Blueberry is one of the thinnest exocarp fruits in the world, which is difficult to keep fresh due to the special structure of its skin. 1-Methlcyclopropene (1-MCP) is able to combine with ethylene(ETH) receptor. In this study we investigated the effect of 1-MCP on rotting rate, weight loss ratio, soluble sugar content, titratable acid content, antioxidant enzyme activities and malondialdehyde (MDA) content in blueberry (Vaccinium corymbosun ‘O Neal’ and ‘North Road’) under cold storage. 1-MCP reduced the rotting rate, weight loss ratio and MDA content, while keeping high-leveled stability in antioxidant enzyme activities, soluble sugar content and titratable acid content. These results showed the role of 1-MCP in alleviating the negative effects of blueberry and suggested that 1-MCP could be used as a preservative for keeping thin exocarp fruit in fresh.

  12. Development of coaxial rotating-plasma gun

    International Nuclear Information System (INIS)

    Ikehata, Takashi; Tanabe, Toshio; Mase, Hiroshi

    1985-01-01

    A rotating-plasma gun has been devised to produce plasma streams with higher rotational velocities. The working mechanism of the gun and the results of a preliminary experiment have been described. (author)

  13. ATA injector-gun calculations

    International Nuclear Information System (INIS)

    Paul, A.C.

    1981-01-01

    ATA is a pulsed, 50 ns 10 KA, 50 MeV linear induction electron accelerator at LLNL. The ETA could be used as an injector for ATA. However the possibility of building a new injector gun for ATA, raised the question as to what changes from the ETA gun in electrode dimensions or potentials, if any, should be considered. In this report the EBQ code results for the four electrode configurations are reviewed and an attempt is made to determine the geometrical scaling laws appropriate to these ETA type gun geometries. Comparison of these scaling laws will be made to ETA operation. The characteristic operating curves for these geometries will also be presented and the effect of washer position determined. It will be shown that emittance growth will impose a limitation on beam current for a given anode potential before the virtual cathode limit is reached

  14. Plasma focusing in coaxial gun

    International Nuclear Information System (INIS)

    Soliman, H.M.; Masoud, M.M.; El-Khalafawy, T.

    1986-01-01

    A capacitor bank has been discharged between two coaxial electrodes of 6.6 cm outer diameter, 3.2 cm inner diameter and length of 31.5 cm. filled with hydrogen gas at pressure of 310 μHg. Results show that, the axial and radial plasma current reach a maximum value at a position adjacent to the gun muzzle, at which the plasma focus occurs. The measurement of the electron temperature and density and azimuthal electric field along the axis of the expansion chamber, gives a maximum value at z∼18 cm from the gun muzzle, while the axial plasma current and velocity has a minimum value at that position. These results indicate that a second point of a plasma focus has been formed at z∼18 cm from the gun muzzle, along the axis of the expansion chamber

  15. Increased MCP-1 gene expression in monocytes of severe OSA patients and under intermittent hypoxia.

    Science.gov (United States)

    Chuang, Li-Pang; Chen, Ning-Hung; Lin, Yuling; Ko, Wen-Shan; Pang, Jong-Hwei S

    2016-03-01

    Obstructive sleep apnea (OSA) is known to be a risk factor of coronary artery disease. Monocyte chemoattractant protein-1 (MCP-1), as a critical factor for monocyte infiltration, is known to play a role in the development of atherosclerosis. This study aimed to investigate the effect of intermittent hypoxia, the hallmark of OSA, on the MCP-1 expression of monocytes. Peripheral blood was sampled from 61 adults enrolled for suspected OSA. RNA was prepared from the isolated monocytes for the analysis of MCP-1. The effect of in vitro intermittent hypoxia on the regulation and function of MCP-1 was investigated on THP-1 monocytic cells and human monocytes. The mRNA and secreted protein levels were investigated by RT/real-time PCR and enzyme-linked immunosorbent assay, respectively. Monocytic MCP-1 gene expression was found to be increased significantly in severe OSA patients. In vitro intermittent hypoxia was demonstrated to increase the mRNA and protein expression levels of MCP-1 dose- and time-dependently in THP-1 monocytic cells. The MCP-1 mRNA expression in monocytes isolated from OSA patient was induced to a much higher level compared to that from normal control. Pre-treatment with inhibitor for p42/44 MAPK or p38 MAPK suppressed the activation of MCP-1 expression by intermittent hypoxia. This is the first study to demonstrate the increase of MCP-1 gene expression in monocytes of severe OSA patients. In addition, monocytic MCP-1 gene expression can be induced under intermittent hypoxia.

  16. Lasers for RF guns: Proceedings

    International Nuclear Information System (INIS)

    Srinivasan-Rao, T.

    1994-01-01

    In the past decade, laser driven RF guns have matured from a device under development to a proven source for high brightness and low emittance electron beams. The reliability of the electron beam from these sources is dictated by the laser system that drives it. In addition, capabilities of the laser systems play a vital role in the design of the electron source for future machines such as the TESLA and NLC. The purpose of this workshop was to provide a forum for discussing the design criteria for the laser systems so that the reliability of the existing sources could be improved and the future machines could be serviced. The Workshop brought together experts in RF Guns, accelerators, and lasers, from both the commercial and academic community. Most of the presentations, discussions and conclusions at the workshop are included in these proceedings. The contents are divided into three sections, Section I contains the invited talks that outline the requirements of the RF Guns and the capabilities of the laser systems to meet these requirements. Section II includes most of the papers presented in the poster session. These papers describe various laser systems used with electron guns, schemes to modify the laser beam profile to optimize the electron bunch, and computer simulations of electron trajectories. Section III contains the summaries of the working groups. As the summary section indicates, with sufficient feed back systems, the electron gun could be made to operate reliably with minimum downtime, using commercial lasers currently available. The design of laser systems for future colliders depend critically on the choice of the cathode m the gun and its efficiency. Tentative designs of laser systems for the TESLA test facility and LCLS had been drawn assuming a copper cathode. Using a more efficient cathode will ease the energy requirement of the laser and simplify the design. The individual papers have been cataloged separately elsewhere

  17. Automatic targeting of plasma spray gun

    International Nuclear Information System (INIS)

    Abbatiello, L.A.; Neal, R.E.

    1978-01-01

    A means for monitoring the material portion in the flame of a plasma spray gun during spraying operations is described. A collimated detector, sensitive to certain wavelengths of light emission, is used to locate the centroid of the material with each pass of the gun. The response from the detector is then relayed to the gun controller to be used to automatically realign the gun

  18. Automatic targeting of plasma spray gun

    Science.gov (United States)

    Abbatiello, Leonard A.; Neal, Richard E.

    1978-01-01

    A means for monitoring the material portion in the flame of a plasma spray gun during spraying operations is provided. A collimated detector, sensitive to certain wavelengths of light emission, is used to locate the centroid of the material with each pass of the gun. The response from the detector is then relayed to the gun controller to be used to automatically realign the gun.

  19. Simulation of the electron collection efficiency of a PMT based on the MCP coated with high secondary yield material

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Lin, E-mail: chenlin@opt.cn [State Key Laboratory of Transient Optics and Photonics, Xi' an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi' an 710119 (China); Graduate School of Chinese Academy of Sciences (CAS), Beijing 100049 (China); Xi' an Jiaotong University, Xi' an 710049 (China); Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan 030006 (China); Tian, Jinshou [State Key Laboratory of Transient Optics and Photonics, Xi' an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi' an 710119 (China); Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan 030006 (China); Zhao, Tianchi [Institute of High Energy Physics (IHEP) of CAS, Beijing 100049 (China); Liu, Chunliang [Xi' an Jiaotong University, Xi' an 710049 (China); Liu, Hulin; Wei, Yonglin; Sai, Xiaofeng [State Key Laboratory of Transient Optics and Photonics, Xi' an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi' an 710119 (China); Chen, Ping [State Key Laboratory of Transient Optics and Photonics, Xi' an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi' an 710119 (China); Graduate School of Chinese Academy of Sciences (CAS), Beijing 100049 (China); Wang, Xing; Lu, Yu [State Key Laboratory of Transient Optics and Photonics, Xi' an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi' an 710119 (China); Hui, Dandan [State Key Laboratory of Transient Optics and Photonics, Xi' an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi' an 710119 (China); Graduate School of Chinese Academy of Sciences (CAS), Beijing 100049 (China)

    2016-11-01

    Owning to the serious loss of photoelectrons striking at the input electrode of traditional microchannel plate (MCP), photoelectron collection efficiency (CE) of photomultiplier tubes based on MCP (MCP-PMTs) fluctuates around the MCP open area fraction and cannot make a breakthrough. Depositing a thin film of high secondary electron yield material on the MCP is proposed as an effective approach to improve the CE. The available simulation and experimental data to validate it, however, is sparse. In our work, a three-dimensional small area MCP model is developed in CST Studio Suite to evaluate the collection efficiencies of PMTs based on the traditional MCP and the coated one, respectively. Results predict that CE of the PMT based on the coated MCP has a significant increase and a better uniformity, which is expected to reach 100%.

  20. Beam Dynamics Simulation of Photocathode RF Electron Gun at the PBP-CMU Linac Laboratory

    Science.gov (United States)

    Buakor, K.; Rimjaem, S.

    2017-09-01

    Photocathode radio-frequency (RF) electron guns are widely used at many particle accelerator laboratories due to high quality of produced electron beams. By using a short-pulse laser to induce the photoemission process, the electrons are emitted with low energy spread. Moreover, the photocathode RF guns are not suffered from the electron back bombardment effect, which can cause the limited electron current and accelerated energy. In this research, we aim to develop the photocathode RF gun for the linac-based THz radiation source. Its design is based on the existing gun at the PBP-CMU Linac Laboratory. The gun consists of a one and a half cell S-band standing-wave RF cavities with a maximum electric field of about 60 MV/m at the centre of the full cell. We study the beam dynamics of electrons traveling through the electromagnetic field inside the RF gun by using the particle tracking program ASTRA. The laser properties i.e. transverse size and injecting phase are optimized to obtain low transverse emittance. In addition, the solenoid magnet is applied for beam focusing and emittance compensation. The proper solenoid magnetic field is then investigated to find the optimum value for proper emittance conservation condition.

  1. How to prevent ripening blockage in 1-MCP-treated 'Conference' pears.

    Science.gov (United States)

    Chiriboga, Maria-Angeles; Schotsmans, Wendy C; Larrigaudière, Christian; Dupille, Eve; Recasens, Inmaculada

    2011-08-15

    Some European pear varieties treated with 1-methylcyclopropene (1-MCP) often remain 'evergreen', meaning that their ripening process is blocked and does not resume after removal from cold storage. In this work this was confirmed also to be the case in 'Conference' pears. To reverse the blockage of ripening 1-MCP treatments combined with external exogenous ethylene were tested. 1-MCP treatment of 'Conference' pears is very effective in delaying ripening and, more specifically, softening. The same 1-MCP concentration in different experimental years caused a different response. The higher dose of 1-MCP (600 nL L⁻¹) always resulted in irreversible blockage of ripening, whereas the behaviour of fruit receiving a lower dose (300 nL L⁻¹) depended on the year, and this did not depend on maturity at harvest or on storage conditions. Simultaneous exposure to 1-MCP and exogenous ethylene significantly affected fruit ripening, allowing significant softening to occur but at a lower rate compared with control fruit. The application of exogenous ethylene and 1-MCP simultaneously after harvest permitted restoration of the ripening process after storage in 'Conference' pears, extending the possibility of marketing and consumption. Copyright © 2011 Society of Chemical Industry.

  2. Fueling by coaxial plasma guns

    International Nuclear Information System (INIS)

    Marshall, J.

    1977-01-01

    A review of the operational characteristics of ''snowplow'' and ''deflagration'' coaxial plasma guns is given. The injection of these plasmas into containment fields is discussed. The effect of a background plasma on low-beta injection is mentioned. The use of high-beta injection for reactor plasmas is described

  3. Flit-gun sprayer characteristics

    Directory of Open Access Journals (Sweden)

    J. R. Brown

    1998-05-01

    Full Text Available Six flit-gun sprayers were tested for possible use in mosquito adulticide programs where inexpensive nonmotorized application technology may be required. An analysis of variance for differences in droplets or = 48 µ, droplets/cm², volume median diameters, and mosquito mortality is provided. As shown by these data, good results can be achieved with this equipment.

  4. Developments in electron gun simulation

    Science.gov (United States)

    Herrmannsfeldt, W. B.

    1997-01-01

    This paper will discuss the developments in the electron gun simulation programs that are based on EGUN and its derivatives and supporting programs. Much of the code development has been inspired by technology changes in computer hardware; the implications on EGN2 of this evolution will be discussed. Some examples and a review of the capabilities of the EGUN family will be described.

  5. Developments in electron gun simulation

    International Nuclear Information System (INIS)

    Herrmannsfeldt, W.B.

    1994-05-01

    This paper will discuss the developments in the electron gun simulation programs that are based on EGUN and its derivatives and supporting programs. Much of the code development has been inspired by technology changes in computer hardware; the implications on EGN2 of this evolution will be discussed. Some examples and a review of the capabilities of the EGUN family will be described

  6. Characteristics of the ETA gun

    International Nuclear Information System (INIS)

    Paul, A.C.; Neil, V.K.; Craig, G.D.; Fessenden, T.J.

    1981-01-01

    The Experimental Test Accelerator (ETA) is a linear induction device consisting of a 2.5-MV electron gun and ten 0.25-MV accelerating units designed to produce a 10-kA beam of electrons at 5 MeV. Calculations with the computer code EBQ as well as experimental measurements indicate that the current produced by the gun is limited by two phenomena. The first arises from the variation of particle energy with time during the pulse. Only particles with energy within a limited range can be transported by the focusing coils in the gun: therefore the variation of the gun's output current with time is determined by the coil settings. The second effect results from a collective interaction at sufficiently large current to cause a virtual cathode to form a few centimeters past the extraction grid. Operation in this regime results in greatly increased beam emittance and poor beam transport through the accelerator. Results of the code calculations are compared with experimental data and found to be in good agreement. (author)

  7. Electric rail gun application to space propulsion

    International Nuclear Information System (INIS)

    Barber, J.P.

    1979-01-01

    The paper examines the possibility of using the DC electric gun principles as a space vehicle propulsion system, capable of producing intermediate thrust levels. The application of an electromagnetic launch technique, called the DC electric rail gun, to the space propulsion concept of O'Neill, is examined. It is determined that the DC electric rail gun offers very high projectile accelerations and a very significant potential for reducing the size and mass of a reaction motor for space application. A detailed description of rail gun principles is given and some simple expressions for the accelerating force, gun impedance, power supply requirements, and system performance are discussed

  8. Electron gun for technological linear accelerator

    International Nuclear Information System (INIS)

    Khodak, I.V.; Kushnir, V.A.; Mirochenko, V.V.; Stepin, D.L.; Zavada, L.M.

    2000-01-01

    The work is purposed to the design of diode electron gun for powerful technologic electron linac and to experimental investigations of the beam parameters at the gun exit.The gun feature is the quick cathode replacement.This is very impotent for operating of the accelerator.The gun optics and beam parameters were calculated using the EGUN code.Beam parameters were investigated as at the special test stand so as component of the linac injector.The gun produces the beam current of 2 A at the anode voltage 25 kV.Measured beam parameters correspond to calculated results

  9. RF Design of the LCLS Gun

    International Nuclear Information System (INIS)

    Limborg-Deprey, C.

    2010-01-01

    Final dimensions for the LCLS RF gun are described. This gun, referred to as the LCLS gun, is a modified version of the UCLA/BNL/SLAC 1.6 cell S-Band RF gun (1), referred to as the prototype gun. The changes include a larger mode separation (15 MHz for the LCLS gun vs. 3.5 MHz for the prototype gun), a larger radius at the iris between the 2 cells, a reduced surface field on the curvature of the iris between the two cells, Z power coupling, increased cooling channels for operation at 120 Hz, dual rf feed, deformation tuning of the full cell, and field probes in both cells. Temporal shaping of the klystron pulse, to reduce the average power dissipated in the gun, has also been adopted. By increasing the mode separation, the amplitude of the 0-mode electric field on the cathode decreases from 10% of the peak on axis field for the prototype gun to less than 3% for the LCLS gun for the steady state fields. Beam performance is improved as shown by the PARMELA simulations. The gun should be designed to accept a future load lock system. Modifications follow the recommendations of our RF review committee (2). Files and reference documents are compiled in Section IV.

  10. IP-10, MCP-1, MCP-2, MCP-3, and IL-1RA hold promise as biomarkers for infection with M. tuberculosis in a whole blood based T-cell assay

    DEFF Research Database (Denmark)

    Ruhwald, Morten; Bjerregaard-Andersen, Morten; Rabna, Paulo

    2009-01-01

    and mitogen in the Quantiferon In Tube test tubes. Levels of biomarkers were measured using Luminex and ELISA (IFN-gamma). RESULTS: We found all five new biomarkers were expressed in significantly higher concentrations compared to IFN-gamma. IP-10 and MCP-3 levels in the un-stimulated samples were higher...

  11. Surface charge compensation for a highly charged ion emission microscope

    International Nuclear Information System (INIS)

    McDonald, J.W.; Hamza, A.V.; Newman, M.W.; Holder, J.P.; Schneider, D.H.G.; Schenkel, T.

    2003-01-01

    A surface charge compensation electron flood gun has been added to the Lawrence Livermore National Laboratory (LLNL) highly charged ion (HCI) emission microscope. HCI surface interaction results in a significant charge residue being left on the surface of insulators and semiconductors. This residual charge causes undesirable aberrations in the microscope images and a reduction of the Time-Of-Flight (TOF) mass resolution when studying the surfaces of insulators and semiconductors. The benefits and problems associated with HCI microscopy and recent results of the electron flood gun enhanced HCI microscope are discussed

  12. Relationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study

    Directory of Open Access Journals (Sweden)

    Murea Mariana

    2012-11-01

    Full Text Available Abstract Background Monocyte chemoattractant protein-1 (MCP-1 plays important roles in kidney disease susceptibility and atherogenesis in experimental models. Relationships between serum MCP-1 concentration and early nephropathy and subclinical cardiovascular disease (CVD were assessed in African Americans (AAs with type 2 diabetes (T2D. Methods Serum MCP-1 concentration, urine albumin:creatinine ratio (ACR, estimated glomerular filtration rate (eGFR, and atherosclerotic calcified plaque (CP in the coronary and carotid arteries and infrarenal aorta were measured in 479 unrelated AAs with T2D. Generalized linear models were fitted to test for associations between MCP-1 and urine ACR, eGFR, and CP. Results Participants were 57% female, with mean ± SD (median age 55.6±9.5 (55.0 years, diabetes duration 10.3±8.2 (8.0 years, urine ACR 149.7±566.7 (14.0 mg/g, CKD-EPI eGFR 92.4±23.3 (92.0 ml/min/1.73m2, MCP-1 262.9±239.1 (224.4 pg/ml, coronary artery CP 280.1±633.8 (13.5, carotid artery CP 47.1±132.9 (0, and aorta CP 1616.0±2864.0 (319.0. Adjusting for age, sex, smoking, HbA1c, BMI, and LDL, serum MCP-1 was positively associated with albuminuria (parameter estimate 0.0021, P=0.04 and negatively associated with eGFR (parameter estimate −0.0003, P=0.001. MCP-1 remained associated with eGFR after adjustment for urine ACR. MCP-1 levels did not correlate with the extent of CP in any vascular bed, HbA1c or diabetes duration, but were positively associated with BMI. No interaction between BMI and MCP-1 was detected on nephropathy outcomes. Conclusions Serum MCP-1 levels are associated with eGFR and albuminuria in AAs with T2D. MCP-1 was not associated with subclinical CVD in this population. Inflammation appears to play important roles in development and/or progression of kidney disease in AAs.

  13. MCP-1 in urine as biomarker of disease activity in Systemic Lupus Erythematosus.

    Science.gov (United States)

    Barbado, Julia; Martin, Debora; Vega, Luisa; Almansa, Raquel; Gonçalves, Lisbeth; Nocito, Mercedes; Jimeno, Antonio; Ortiz de Lejarazu, Raúl; Bermejo-Martin, Jesus F

    2012-11-01

    Conventional clinical parameters are not sensitive or specific enough for detecting ongoing disease activity in the Systemic Lupus Erythematosus (SLE). Measurement of cytokines in urine is an encouraging approach to detection of early flares in this disease. Here we have profiled 27 different cytokines, chemokines and celular growth factors in the urine of 48 patients previously diagnosed of SLE as potential biomarkers of disease activity. Correlation analysis with Bonferroni correction showed that MCP-1 was the only immune mediator which levels in urine correlated directly with the SLE Disease Activity Index 2000 (SLEDAI-2K) score (correlation coefficient, p): MCP-1 (0.45,0.003). MCP-1 correlated inversely with levels of C3 complement protein in serum (-0.50,0.001). MCP-1 showed significant higher levels in patients with severe disease activity in comparison with those exhibiting mild activity. Levels of this chemokine were also higher in patients with severe disease activity in comparison with patients with inactive disease and healthy controls. Areas under receiver operating characteristic curves (AUROC) for detection of severe disease (SLEDAI⩾8) was as follows for MCP-1: [AUROC, (IC95%), p]: [0.81 (0.65-0.96) 0.003]. In addition, MCP-1 showed a good result in the AUROC analysis for detecting renal involvement [0.70 (0.52-0.87) 0.050]. When correlation analysis were repeated excluding those patients with active renal disease (n=14), levels of MCP-1 in urine kept on showing a significant positive association with SLEDAI-2K score. In conclusion, multiplex-based cytokine profiling in urine demonstrated the superiority of MCP-1 over a wide range of cytokines as biomarker of disease activity in SLE. Copyright © 2012 Elsevier Ltd. All rights reserved.

  14. 1-MCP pretreatment prevents bud and flower abscission in Dendrobium orchids

    NARCIS (Netherlands)

    Uthaichay, N.; Ketsa, S.; Doorn, van W.G.

    2007-01-01

    Dendrobium orchid inflorescences were treated for 4 h at 25 °C with or without 100¿500 nl/l 1-MCP and were then placed in water at 25 °C to follow abscission. In controls, depending on the experiment, 20¿80% of the floral buds and 0¿20% of the open flowers abscised within 1 week. The 1-MCP

  15. Electronic emission and electron guns

    International Nuclear Information System (INIS)

    Roy, Amitava

    2010-01-01

    This paper reviews the process of electron emission from metal surface. Although electrons move freely in conductors like metals, they normally do not leave the metal without some manipulation. In fact, heating and bombardment are the two primary ways in which electrons are emitted through the use of a heating element behind the cathode (termed thermionic emission) or as a result of bombardment with a beam of electrons, ions, or metastable atoms (termed secondary emission). Another important emission mechanism called Explosive Electron Emission (EEE) is also often used in various High Voltage Pulse Power Systems to generate very high current (few hundreds of kA) pulsed electron beams. The electron gun is the device in that it shoots off a continuous (or pulsed) stream of electrons. A brief idea about the evolution of the electron gun components and their basis of functioning are also discussed. (author)

  16. Anti-inflammatory effect of resveratrol on TNF-α-induced MCP-1 expression in adipocytes

    International Nuclear Information System (INIS)

    Zhu Jian; Yong Wei; Wu Xiaohong; Yu Ying; Lv Jinghuan; Liu Cuiping; Mao Xiaodong; Zhu Yunxia; Xu Kuanfeng; Han Xiao; Liu Chao

    2008-01-01

    Chronic low-grade inflammation characterized by adipose tissue macrophage accumulation and abnormal cytokine production is a key feature of obesity and type 2 diabetes. Adipose-tissue-derived monocyte chemoattractant protein (MCP)-1, induced by cytokines, has been shown to play an essential role in the early events during macrophage infiltration into adipose tissue. In this study we investigated the effects of resveratrol upon both tumor necrosis factor (TNF)-α-induced MCP-1 gene expression and its underlying signaling pathways in 3T3-L1 adipoctyes. Resveratrol was found to inhibit TNF-α-induced MCP-1 secretion and gene transcription, as well as promoter activity, which based on down-regulation of TNF-α-induced MCP-1 transcription. Nuclear factor (NF)-κB was determined to play a major role in the TNF-α-induced MCP-1 expression. Further analysis showed that resveratrol inhibited DNA binding activity of the NF-κB complex and subsequently suppressed NF-κB transcriptional activity in TNF-α-stimulated cells. Finally, the inhibition of MCP-1 may represent a novel mechanism of resveratrol in preventing obesity-related pathologies

  17. Melanocyte pigmentation inversely correlates with MCP-1 production and angiogenesis-inducing potential.

    Science.gov (United States)

    Adini, Irit; Adini, Avner; Bazinet, Lauren; Watnick, Randolph S; Bielenberg, Diane R; D'Amato, Robert J

    2015-02-01

    The incidence of certain angiogenesis-dependent diseases is higher in Caucasians than in African Americans. Angiogenesis is amplified in wound healing and cornea models in albino C57 mice compared with black C57 mice. Moreover, mouse and human melanocytes with low pigmentation stimulate endothelial cell (EC) proliferation and migration in vitro more than melanocytes with high pigmentation. This effect is due, in part, to the secretion of an angiogenic protein called fibromodulin (FMOD) from lowly pigmented melanocytes. Herein, we expand upon the mechanism contributing to increased angiogenesis in lighter skin and report that monocyte chemotactic protein-1 (MCP-1) is secreted by nonpigmented mouse melanocytes by 5- to 10-fold more than pigmented melanocytes. MCP-1 protein stimulates EC proliferation and migration in vitro and angiogenesis in vivo. Mechanistic studies determine that FMOD is upstream of MCP-1 and promotes its secretion from both melanocytes and activated ECs via stimulation of NF-κB activity. Mice injected with FMOD-neutralizing antibodies show 2.3-fold decreased levels of circulating MCP-1. Human studies confirmed that, on average, Caucasians have 2-fold higher serum levels of MCP-1 than African Americans. Taken together, this study implicates the FMOD/MCP-1 pathway in the regulation of angiogenesis by local melanocytes and suggests that melanogenic activity may protect against aberrant angiogenic diseases. © FASEB.

  18. Measurements of Transverse Emittance for RF Photocathode Gun at the PAL

    CERN Document Server

    Park Jang Ho; Park, Sung-Ju; Soo Ko In; Wang, Xijie; Woon Parc, Yong; Xiang, Dao

    2005-01-01

    A BNL GUN-IV type RF photo-cathode gun is under fabrication for use in the FIR (Far Infra-Red) facility being built at the Pohang Accelerator Laboratory (PAL). Performance test of the gun will include the measurement of transverse emittance profile along the longitudinal direction. Successful measurement of the emittance profile will provide powerful tool for the commissioning of the 4GLS (4th generation light source) injectors based on the emittance compensation principle. We are going to achieve this withthe use of pepper-pot based emittance meters that can be moved along the longitudinal direction. In this article, we present design considerations on the emittance meter with the resolution of 1 mm mrad.

  19. Effects of Exposure to Gun Violence in Movies on Children's Interest in Real Guns.

    Science.gov (United States)

    Dillon, Kelly P; Bushman, Brad J

    2017-11-01

    More US children die by accidental gun use than children in other developed countries. One factor that can influence children's interest in guns is exposure to media containing guns. To test whether children who see a movie containing guns will handle a real gun longer and will pull the trigger more times than children who see the same movie not containing guns. One hundred four children aged 8 to 12 years recruited through advertisements were randomly assigned in pairs to watch a 20-minute PG-rated movie containing or not containing guns in a university laboratory. Children then played with toys and games in a room for 20 minutes while being video recorded. A cabinet in the room contained a real (disabled) gun with a sensor counting trigger pulls. Recordings were coded for the time spent holding the gun and in aggressive play. Data were collected from July 15, 2015, through January 1, 2016, and analyzed using generalized estimating equations (Tweedie log-link for time spent holding the gun; Poisson log-link for pulling the trigger). The 2 main outcomes were time spent holding the gun and the number of trigger pulls. Control variables included sex, age, trait aggressiveness, exposure to violent media, interest in guns, and number of guns at home. Among the 104 study participants (62 boys [59.6%] and 42 girls [40.4%]; mean (SD) age, 9.9 [1.5] years), the adjusted median number of trigger pulls among children who saw the movie containing guns was 2.8 (interquartile range [IQR], 0.2-2.8) compared with 0.01 (IQR, 0.01-0.2) among children who saw the movie not containing guns (adjusted odds ratio, 22.3; 95% CI, 6.0-83.4; P gun among children who saw a movie containing guns was 53.1 (IQR, 35.5-53.1) compared with 11.1 (IQR, 10.7-16.7) among children who saw the movie not containing guns (adjusted odds ratio, 3.0; 95% CI, 0.9-9.9; P = .07). Qualitative analyses on 4 pairs from each condition found that children who saw the movie containing guns also played more

  20. Guns, Suicide, COPD and Sleep

    Directory of Open Access Journals (Sweden)

    Robbins RA

    2018-03-01

    Full Text Available No abstract available. Article truncated at 150 words. Within the past year two tragic events, the shootings in Las Vegas and Florida have renewed the debate about guns. The politics and the money that fuels the political debate have sharply divided politicians. As tragic as these mass shootings are, deaths by suicide far outnumber the loss of live in these shootings. In 2014 suicide was the tenth most common cause of death with 42,826 lives lost (1. Half of the suicides were by firearm (21,386. The medical profession has traditionally been reluctant to speak about politically sensitive issues such as abortion, sexuality, and guns. However, beginning early in this millennium some medical societies such as the American Academy of Pediatrics, the US Preventative Services Task Force and even the Department of Veterans Affairs were suggesting physicians ask patients about gun behavior, but a few patients complained (2-5. There were some anecdotal reports of patients feeling “pressured” to answer …

  1. Self-bunching electron guns

    CERN Document Server

    Mako, F; Weilhammer, Peter

    1999-01-01

    We report on three electron gun projects that are aimed at power tube and injector applications. The purpose of the work is to develop robust electron guns which produce self-bunched, high-current-density beams. We have demonstrated cold emission, long life, and tolerance to contamination. The cold emission process is based on secondary electron emission. FMT has studied this resonant bunching process which gives rise to high current densities (0.01-5 kA/cm/sup 2/), high charge bunches (up to 100 nC/bunch), and short pulses (1-100 ps) for frequencies from 1 to 12 GHz. The beam pulse width is nominally ~5% of the RF period. The first project is the L-Band Micro-Pulse Gun (MPG). Measurements show ~40 ps long microbunches at ~20 A/cm/sup 2/ without contamination due to air exposure. Lifetime testing has been carried out for about 18 months operating at 1.25 GHz for almost 24 hours per day at a repetition rate of 300 Hz and 5 mu s-long macro- pulses. About 5.8*10/sup 13/ micro-bunches or 62,000 coulombs have pass...

  2. X-Band RF Gun Development

    International Nuclear Information System (INIS)

    Vlieks, A.E.

    2012-01-01

    In support of the MEGa-ray program at LLNL and the High Gradient research program at SLAC, a new X-band multi-cell RF gun is being developed. This gun, similar to earlier guns developed at SLAC for Compton X-ray source program, will be a standing wave structure made of 5.5 cells operating in the pi mode with copper cathode. This gun was designed following criteria used to build SLAC X-band high gradient accelerating structures. It is anticipated that this gun will operate with surface electric fields on the cathode of 200 MeV/m with low breakdown rate. RF will be coupled into the structure through a final cell with symmetric duel feeds and with a shape optimized to minimize quadrupole field components. In addition, geometry changes to the original gun, operated with Compton X-ray source, will include a wider RF mode separation, reduced surface electric and magnetic fields.

  3. The polarized electron gun for the SLC

    International Nuclear Information System (INIS)

    Schultz, D.C.; Clendenin, J.; Frisch, J.; Hoyt, E.; Klaisner, L.; Woods, M.; Wright, D.; Zolotorev, M.

    1992-03-01

    A new polarized electron gun for use on the SLC at SLAC has been built and tested. It is a diode gun with a laser driven GaAs photocathode. It is designed to provide short (2ns) pulses of 10 A at 160 kV at 120 Hz. The design features of the gun and results from a testing program on a new and dedicated beam line are presented. Early results from operation on the SLC will also be shown

  4. Rate control for electron gun evaporation

    International Nuclear Information System (INIS)

    Schellingerhout, A.J.G.; Janocko, M.A.; Klapwijk, T.M.; Mooij, J.E.

    1989-01-01

    Principles for obtaining high-quality rate control for electron gun evaporation are discussed. The design criteria for rate controllers are derived from this analysis. Results are presented which have been obtained with e-guns whose evaporation rate is controlled by a Wehnelt electrode or by sweeping of the electron beam. Further improvements of rate stability can be obtained by improved design of e-guns and power supplies

  5. RF gun using laser-triggered photocathode

    International Nuclear Information System (INIS)

    Akiyama, H.; Otake, Y.; Naito, T.; Takeuchi, Y.; Yoshioka, M.

    1992-01-01

    An RF gun using laser-triggered photocathode has many advantages as an injector of the linear colliders since it can generate a low emittance and high current pulsed beam. The experimental facility for the RF gun, such as an RF system, a laser system and a photocathode have been fabricated to study the fundamental characteristics. The dynamics of the RF gun has also studied by the 1D sheet beam model. (author)

  6. Racism, gun ownership and gun control: biased attitudes in US whites may influence policy decisions.

    Science.gov (United States)

    O'Brien, Kerry; Forrest, Walter; Lynott, Dermot; Daly, Michael

    2013-01-01

    Racism is related to policies preferences and behaviors that adversely affect blacks and appear related to a fear of blacks (e.g., increased policing, death penalty). This study examined whether racism is also related to gun ownership and opposition to gun controls in US whites. The most recent data from the American National Election Study, a large representative US sample, was used to test relationships between racism, gun ownership, and opposition to gun control in US whites. Explanatory variables known to be related to gun ownership and gun control opposition (i.e., age, gender, education, income, conservatism, anti-government sentiment, southern vs. other states, political identification) were entered in logistic regression models, along with measures of racism, and the stereotype of blacks as violent. Outcome variables included; having a gun in the home, opposition to bans on handguns in the home, support for permits to carry concealed handguns. After accounting for all explanatory variables, logistic regressions found that for each 1 point increase in symbolic racism there was a 50% increase in the odds of having a gun at home. After also accounting for having a gun in the home, there was still a 28% increase in support for permits to carry concealed handguns, for each one point increase in symbolic racism. The relationship between symbolic racism and opposition to banning handguns in the home (OR1.27 CI 1.03,1.58) was reduced to non-significant after accounting for having a gun in the home (OR1.17 CI.94,1.46), which likely represents self-interest in retaining property (guns). Symbolic racism was related to having a gun in the home and opposition to gun control policies in US whites. The findings help explain US whites' paradoxical attitudes towards gun ownership and gun control. Such attitudes may adversely influence US gun control policy debates and decisions.

  7. Racism, gun ownership and gun control: biased attitudes in US whites may influence policy decisions.

    Directory of Open Access Journals (Sweden)

    Kerry O'Brien

    Full Text Available OBJECTIVE: Racism is related to policies preferences and behaviors that adversely affect blacks and appear related to a fear of blacks (e.g., increased policing, death penalty. This study examined whether racism is also related to gun ownership and opposition to gun controls in US whites. METHOD: The most recent data from the American National Election Study, a large representative US sample, was used to test relationships between racism, gun ownership, and opposition to gun control in US whites. Explanatory variables known to be related to gun ownership and gun control opposition (i.e., age, gender, education, income, conservatism, anti-government sentiment, southern vs. other states, political identification were entered in logistic regression models, along with measures of racism, and the stereotype of blacks as violent. Outcome variables included; having a gun in the home, opposition to bans on handguns in the home, support for permits to carry concealed handguns. RESULTS: After accounting for all explanatory variables, logistic regressions found that for each 1 point increase in symbolic racism there was a 50% increase in the odds of having a gun at home. After also accounting for having a gun in the home, there was still a 28% increase in support for permits to carry concealed handguns, for each one point increase in symbolic racism. The relationship between symbolic racism and opposition to banning handguns in the home (OR1.27 CI 1.03,1.58 was reduced to non-significant after accounting for having a gun in the home (OR1.17 CI.94,1.46, which likely represents self-interest in retaining property (guns. CONCLUSIONS: Symbolic racism was related to having a gun in the home and opposition to gun control policies in US whites. The findings help explain US whites' paradoxical attitudes towards gun ownership and gun control. Such attitudes may adversely influence US gun control policy debates and decisions.

  8. Racism, Gun Ownership and Gun Control: Biased Attitudes in US Whites May Influence Policy Decisions

    OpenAIRE

    O?Brien, Kerry; Forrest, Walter; Lynott, Dermot; Daly, Michael

    2013-01-01

    OBJECTIVE: Racism is related to policies preferences and behaviors that adversely affect blacks and appear related to a fear of blacks (e.g., increased policing, death penalty). This study examined whether racism is also related to gun ownership and opposition to gun controls in US whites. METHOD: The most recent data from the American National Election Study, a large representative US sample, was used to test relationships between racism, gun ownership, and opposition to gun control in US wh...

  9. Racism, Gun Ownership and Gun Control: Biased Attitudes in US Whites May Influence Policy Decisions

    Science.gov (United States)

    O’Brien, Kerry; Forrest, Walter; Lynott, Dermot; Daly, Michael

    2013-01-01

    Objective Racism is related to policies preferences and behaviors that adversely affect blacks and appear related to a fear of blacks (e.g., increased policing, death penalty). This study examined whether racism is also related to gun ownership and opposition to gun controls in US whites. Method The most recent data from the American National Election Study, a large representative US sample, was used to test relationships between racism, gun ownership, and opposition to gun control in US whites. Explanatory variables known to be related to gun ownership and gun control opposition (i.e., age, gender, education, income, conservatism, anti-government sentiment, southern vs. other states, political identification) were entered in logistic regression models, along with measures of racism, and the stereotype of blacks as violent. Outcome variables included; having a gun in the home, opposition to bans on handguns in the home, support for permits to carry concealed handguns. Results After accounting for all explanatory variables, logistic regressions found that for each 1 point increase in symbolic racism there was a 50% increase in the odds of having a gun at home. After also accounting for having a gun in the home, there was still a 28% increase in support for permits to carry concealed handguns, for each one point increase in symbolic racism. The relationship between symbolic racism and opposition to banning handguns in the home (OR1.27 CI 1.03,1.58) was reduced to non-significant after accounting for having a gun in the home (OR1.17 CI.94,1.46), which likely represents self-interest in retaining property (guns). Conclusions Symbolic racism was related to having a gun in the home and opposition to gun control policies in US whites. The findings help explain US whites’ paradoxical attitudes towards gun ownership and gun control. Such attitudes may adversely influence US gun control policy debates and decisions. PMID:24204867

  10. Operation of the APS rf gun

    International Nuclear Information System (INIS)

    Lewellen, J. W.

    1998-01-01

    The Advanced Photon Source (APS) has a thermionic-cathode rf gun system capable of providing beam to the APS linac. The gun system consists of a 1.6-cell thermionic-cathode rf gun, a fast kicker for beam current control, and an alpha magnet for bunch compression and injection into the APS linac line. This system is intended for use both as an injector for positron creation, and as a first beam source for the Low-Energy Undulator Test Line (LEUTL) project [1]. The first measured performance characteristics of the gun are presented.

  11. Conceptual Design for CLIC Gun Pulser

    Energy Technology Data Exchange (ETDEWEB)

    Tang, Tao [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2016-01-08

    The Compact Linear Collider (CLIC) is a proposed future electron-positron collider, designed to perform collisions at energies from 0.5 to 5 TeV, with a nominal design optimized for 3 TeV (Dannheim, 2012). The Drive Beam Accelerator consists of a thermionic DC gun, bunching section and an accelerating section. The thermionic gun needs deliver a long (~143us) pulse of current into the buncher. A pulser is needed to drive grid of the gun to generate a stable current output. This report explores the requirements of the gun pulser and potential solutions to regulate grid current.

  12. Hard-driven rail-gun tests

    International Nuclear Information System (INIS)

    Peterson, D.R.; Adams, D.F.; Cummings, C.E.; Fowler, C.M.; Kerrisk, J.F.; Marsh, S.P.; Parker, J.V.

    1983-01-01

    A number of prototype rail-gun designs have been tested, powered by explosive magnetic flux compression generators. Peak currents as high as 1.3 MA were delivered. Rail guns with 50-mm-thick Kevlar fiberwound structural shells were able to survive these high currents with minimum mechanical damage and were refired after enlarging the bores 0.2 to 0.4 mm to remove arc damage. In some tests, mechanical damage occurred that was apparently caused by the rebound of the gun after firing. Although the Kevlar shells had more than adequate strength, they appeared to lack sufficient stiffness, allowing excessive deflections. The use of a steel structural shell with a Kevlar sleeve was an improvement. Intrusion into the seams of the rail guns and condensation of material from the plasma armature were observed. Improved sealing of seams is indicated. In some cases, we suspect maldistribution of current within the gun; that is, not all the current delivered to the breech of the gun seemed to reach the plasma armature. Experiments are being designed to quantify the effects discussed. Rail guns of advanced design are being fabricated. An 18-g titanium projectile was accelerated to 2.4 km/s in a 16-mm-round-bore, 0.6-m-long gun, 4-6 g polycarbonate projectiles were accelerated to 3.5 km/s in 13-mm-square-bore, 1.2-m-long rail guns. All tests were conducted at atmospheric pressure

  13. Gun power source for electron gun of 3 MeV DC accelerator

    International Nuclear Information System (INIS)

    Dewangan, S.; Sharma, D.K.; Nanu, K.

    2011-01-01

    In DC electron beam accelerator electron gun is situated at high voltage terminal which requires constant power irrespective of beam energy. Floating power source is required for gun. This paper describes the scheme of static gun power source derived from parallel coupled voltage multiplier column. (author)

  14. Emittance studies of the BNL/SLAC/UCLA 1.6 cell photocathode rf gun

    International Nuclear Information System (INIS)

    Palmer, D.T.; Miller, R.H.; Wang, X.J.

    1997-01-01

    The symmetrized 1.6 cell S-band photocathode gun developed by the BNL/SLAC/UCLA collaboration is in operation at the Brookhaven Accelerator Test Facility (ATF). A novel emittance compensation solenoid magnet has also been designed, built and is in operation at the ATF. These two subsystems form an emittance compensated photoinjector used for beam dynamics, advanced acceleration and free electron laser experiments at the ATF. The highest acceleration field achieved on the copper cathode is 150 MV/m, and the guns normal operating field is 130 MV/m. The maximum rf pulse length is 3 micros. The transverse emittance of the photoelectron beam were measured for various injection parameters. The 1 nC emittance results are presented along with electron bunch length measurements that indicated that at above the 400 pC, space charge bunch lengthening is occurring. The thermal emittance, ε o , of the copper cathode has been measured

  15. A mechanistic modelling approach to understand 1-MCP inhibition of ethylene action and quality changes during ripening of apples.

    Science.gov (United States)

    Gwanpua, Sunny George; Verlinden, Bert E; Hertog, Maarten Latm; Nicolai, Bart M; Geeraerd, Annemie H

    2017-08-01

    1-Methylcyclopropene (1-MCP) inhibits ripening in climacteric fruit by blocking ethylene receptors, preventing ethylene from binding and eliciting its action. The objective of the current study was to use mathematical models to describe 1-MCP inhibition of apple fruit ripening, and to provide a tool for predicting ethylene production, and two important quality indicators of apple fruit, firmness and background colour. A model consisting of coupled differential equations describing 1-MCP inhibition of apple ripening was developed. Data on ethylene production, expression of ethylene receptors, firmness, and background colour during ripening of untreated and 1-MCP treated apples were used to calibrate the model. An overall adjusted R 2 of 95% was obtained. The impact of time from harvest to treatment, and harvest maturity on 1-MCP efficacy was modelled. Different hypotheses on the partial response of 'Jonagold' apple to 1-MCP treatment were tested using the model. The model was validated using an independent dataset. Low 1-MCP blocking efficacy was shown to be the most likely cause of partial response for delayed 1-MCP treatment, and 1-MCP treatment of late-picked apples. Time from harvest to treatment was a more important factor than maturity for 1-MCP efficacy in 'Jonagold' apples. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  16. Monocyte chemoattractant protein-1 (MCP-1 regulates macrophage cytotoxicity in abdominal aortic aneurysm.

    Directory of Open Access Journals (Sweden)

    Qiwei Wang

    Full Text Available AIMS: In abdominal aortic aneurysm (AAA, macrophages are detected in the proximity of aortic smooth muscle cells (SMCs. We have previously demonstrated in a murine model of AAA that apoptotic SMCs attract monocytes and other leukocytes by producing MCP-1. Here we tested whether infiltrating macrophages also directly contribute to SMC apoptosis. METHODS AND RESULTS: Using a SMC/RAW264.7 macrophage co-culture system, we demonstrated that MCP-1-primed RAWs caused a significantly higher level of apoptosis in SMCs as compared to control macrophages. Next, we detected an enhanced Fas ligand (FasL mRNA level and membrane FasL protein expression in MCP-1-primed RAWs. Neutralizing FasL blocked SMC apoptosis in the co-culture. In situ proximity ligation assay showed that SMCs exposed to primed macrophages contained higher levels of receptor interacting protein-1 (RIP1/Caspase 8 containing cell death complexes. Silencing RIP1 conferred apoptosis resistance to SMCs. In the mouse elastase injury model of aneurysm, aneurysm induction increased the level of RIP1/Caspase 8 containing complexes in medial SMCs. Moreover, TUNEL-positive SMCs in aneurysmal tissues were frequently surrounded by CD68(+/FasL(+ macrophages. Conversely, elastase-treated arteries from MCP-1 knockout mice display a reduction of both macrophage infiltration and FasL expression, which was accompanied by diminished apoptosis of SMCs. CONCLUSION: Our data suggest that MCP-1-primed macrophages are more cytotoxic. MCP-1 appears to modulate macrophage cytotoxicity by increasing the level of membrane bound FasL. Thus, we showed that MCP-1-primed macrophages kill SMCs through a FasL/Fas-Caspase8-RIP1 mediated mechanism.

  17. Theoretical investigation of a travelling-wave rf gun

    International Nuclear Information System (INIS)

    Gao, J.

    1991-12-01

    A travelling-wave type rf gun (TW gun) is investigated theoretically. Analytical formulae concerning energy gain, energy spread, and transverse emittance are derived. After showing the corresponding formulae for the standing-wave rf gun (SW gun), comparisons are made between the two types of rf gun. Finally, some numerical results are calculated to demonstrate further the behaviours of the TW gun, and to compare with those from analytical formulae. (author) 11 refs.; 27 figs

  18. Experimental studies of coaxial plasma gun current

    International Nuclear Information System (INIS)

    Price, D.W.

    1988-01-01

    In this investigation of a coaxial plasma gun, plasma sheath currents and related behavior are examined. Plasma behavior in the gun affects gun characteristics. Plasma gun applications are determined by the plasma behavior. The AFWL PUFF capacitor bank (72 μF, 29 nH, 120 kV) drives the plasma gun using a deuterium fill gas. The gas breakdown site is isolated from the dielectric/vacuum interface in the AFWL system. Two gas values deliver gas in the system. The first delivers gas from the gun breech and the second optional valve delivers gas to the gun muzzle. Currents and voltages are measured by Rogowski coils, B probes and capacitive voltage probes. A O-D slug model is used to predict the current, inductance, gun voltage and plasma sheath velocity. The slug model assumes the sheath transits the gun with all mass in the sheath. In the snowplow mode, the plasma sheath is thin with a sharp current rise and drop. Our system operated in a transition mode between the snowplow and deflagration modes with early snowplow behavior and late deflagration behavior. Neutrons are produced in a plasma pinch at the gun muzzle, indicating snowplow behavior. The slug theory models overall gun behavior to experimental accuracy. Experimental results are compared to four theories for plasma sheath velocities: the Alfven collisionally limited model, the Rosenbluth model, the Fishbine saturated model and a single particle drift model. Experimental velocities vary from 10 5 to 10 6 m/s. Only the single particle drift and the slug model calculations are of the right magnitude (8 x 10 5 m/s). The Fishbine and the Rosenbluth models predict slower velocities (2 x 10 5 m/s). The Alfven model is not applicable to this system

  19. From gun politics to self-defense politics: a feminist critique of the great gun debate.

    Science.gov (United States)

    Carlson, Jennifer D

    2014-03-01

    This article calls attention to a problematic binary produced by public debates surrounding gun rights and gun control-namely, that women must choose armed self-protection or no self-protection at all. I argue that both anti- and pro-gun discourses, drawing on and reproducing race and class privileges, use assumptions about women's physical inferiority to further their agendas. I highlight how both sides have used guns as the proxy for self-defense and conclude by calling for a shift in public discourse to focus on the broader question of the right to self-defense rather than the narrower question of gun rights.

  20. Thioredoxin reductase 1 upregulates MCP-1 release in human endothelial cells

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Zhen-Bo [Institute of Biophysics, Chinese Academy of Sciences, and Graduate School of the Chinese Academy of Sciences, Beijing (China); Shen, Xun, E-mail: shenxun@sun5.ibp.ac.cn [Institute of Biophysics, Chinese Academy of Sciences, and Graduate School of the Chinese Academy of Sciences, Beijing (China)

    2009-09-04

    To know if thioredoxin reductase 1 (TrxR1) plays a role in antioxidant defense mechanisms against atherosclerosis, effect of TrxR1 on expression/release of monocyte chemoattractant protein (MCP-1) was investigated in activated human endothelial-like EAhy926 cells. The MCP-1 release and expression, cellular generation of reactive oxygen species (ROS), nuclear translocation and DNA-binding activity of NF-{kappa}B subunit p65 were assayed in cells either overexpressing recombinant TrxR1 or having their endogenous TrxR1 knocked down. It was found that overexpression of TrxR1 enhanced, while knockdown of TrxR1 reduced MCP-1 release and expression. Upregulation of MCP-1 by TrxR1 was associated with increasing generation of intracellular ROS generation, enhanced nuclear translocation and DNA-binding activity of NF-{kappa}B. Assay using NF-{kappa}B reporter revealed that TrxR1 upregulated transcriptional activity of NF-{kappa}B. This study suggests that TrxR1 enhances ROS generation, NF-{kappa}B activity and subsequent MCP-1 expression in endothelial cells, and may promote rather than prevent vascular endothelium from forming atherosclerotic plaque.

  1. IL-8 and MCP Gene Expression and Production by LPS-Stimulated Human Corneal Stromal Cells

    Directory of Open Access Journals (Sweden)

    Roni M. Shtein

    2012-01-01

    Full Text Available Purpose. To determine time course of effect of lipopolysaccharide (LPS on production of interleukin-8 (IL-8 and monocyte chemotactic protein (MCP by cultured human corneal stromal cells. Methods. Human corneal stromal cells were harvested from donor corneal specimens, and fourth to sixth passaged cells were used. Cell cultures were stimulated with LPS for 2, 4, 8, and 24 hours. Northern blot analysis of IL-8 and MCP gene expression and ELISA for IL-8 and MCP secretion were performed. ELISA results were analyzed for statistical significance using two-tailed Student's t-test. Results. Northern blot analysis demonstrated significantly increased IL-8 and MCP gene expression after 4 and 8 hours of exposure to LPS. ELISA for secreted IL-8 and MCP demonstrated statistically significant increases (P<0.05 after corneal stromal cell stimulation with LPS. Conclusions. This paper suggests that human corneal stromal cells may participate in corneal inflammation by secreting potent leukocyte chemotactic and activating proteins in a time-dependent manner when exposed to LPS.

  2. Self-bunching electron guns

    Science.gov (United States)

    Mako, Frederick M.; Len, L. K.

    1999-05-01

    We report on three electron gun projects that are aimed at power tube and injector applications. The purpose of the work is to develop robust electron guns which produce self-bunched, high-current-density beams. We have demonstrated, in a microwave cavity, self-bunching, cold electron emission, long life, and tolerance to contamination. The cold process is based on secondary electron emission. FMT has studied using simulation codes the resonant bunching process which gives rise to high current densities (0.01-5 kA/cm2), high charge bunches (up to 500 nC/bunch), and short pulses (1-100 ps) for frequencies from 1 to 12 GHz. The beam pulse width is nominally ˜5% of the rf period. The first project is the L-Band Micro-Pulse Gun (MPG). Measurements show ˜40 ps long micro-bunches at ˜20 A/cm2 without contamination due to air exposure. Lifetime testing has been carried out for about 18 months operating at 1.25 GHz for almost 24 hours per day at a repetition rate of 300 Hz and 5 μs-long macro-pulses. Approximately 5.8×1013 micro-bunches or 62,000 coulombs have passed through this gun and it is still working fine. The second project, the S-Band MPG, is now operational. It is functioning at a frequency of 2.85 GHz, a repetition rate of 30 Hz, with a 2 μs-long macro-pulse. It produces about 45 A in the macro-pulse. The third project is a 34.2 GHz frequency-multiplied source driven by an X-Band MPG. A point design was performed at an rf output power of 150 MW at 34.2 GHz. The resulting system efficiency is 53% and the gain is 60 dB. The system efficiency includes the input cavity efficiency, input driver efficiency (a 50 MW klystron at 11.4 GHz), output cavity efficiency, and the post-acceleration efficiency.

  3. The Xygra gun simulation tool.

    Energy Technology Data Exchange (ETDEWEB)

    Garasi, Christopher Joseph; Lamppa, Derek C.; Aubuchon, Matthew S.; Shirley, David Noyes; Robinson, Allen Conrad; Russo, Thomas V.

    2008-12-01

    Inductive electromagnetic launchers, or coilguns, use discrete solenoidal coils to accelerate a coaxial conductive armature. To date, Sandia has been using an internally developed code, SLINGSHOT, as a point-mass lumped circuit element simulation tool for modeling coilgun behavior for design and verification purposes. This code has shortcomings in terms of accurately modeling gun performance under stressful electromagnetic propulsion environments. To correct for these limitations, it was decided to attempt to closely couple two Sandia simulation codes, Xyce and ALEGRA, to develop a more rigorous simulation capability for demanding launch applications. This report summarizes the modifications made to each respective code and the path forward to completing interfacing between them.

  4. God and Guns: Examining Religious Influences on Gun Control Attitudes in the United States

    Directory of Open Access Journals (Sweden)

    Stephen M. Merino

    2018-06-01

    Full Text Available Mass shootings in the United States have generated significant media coverage and public concern, invigorating debates over gun control. Media coverage and academic research on gun control attitudes and reactions to mass shootings have paid little attention to the role of religion. Recent research sheds light on the complex relationship between religion and guns, including higher rates of gun ownership and stronger opposition to gun control among white evangelical Protestants. Using nationally representative survey data, this study examines the relationship between religious identity, gun ownership, and support for a range of gun control policies, including proposed remedies for preventing mass shootings. Compared with individuals from other religious traditions, evangelical Protestants are most opposed to stricter gun control laws and enforcement, even with statistical controls for gun ownership and demographic characteristics. Rather, they favor individualistic solutions and putting more emphasis on religious values in their social surroundings. I discuss how these findings reflect the cultural tools evangelical Protestants use to construct their understandings of social problems, including gun violence, and the broader implications for gun policy in the United States.

  5. The Effects of Cueing and Framing on Youth Attitudes towards Gun Control and Gun Rights

    Directory of Open Access Journals (Sweden)

    Stephen Wu

    2018-02-01

    Full Text Available I analyze attitudes towards gun control from a recent survey of American high school students. For students who most closely identify as Republicans, cueing them to think about prior school shootings increases their agreement that armed staff in schools will improve safety and arming citizens will reduce risk of mass shootings. For those identifying as Democrats and Independents, providing them with selective information that certain states have loose gun control laws and low rates of gun violence makes them more supportive of gun rights. For Republicans, providing selective information that certain states have loose gun control laws and high rates of gun violence makes them less supportive of gun rights. These results suggest that emotional cues may exacerbate a priori biases, while informational cues may be more likely to change people’s minds about firearm policies.

  6. Plasma-gun fueling for tokamak reactors

    International Nuclear Information System (INIS)

    Ehst, D.A.

    1980-11-01

    In light of the uncertain extrapolation of gas puffing for reactor fueling and certain limitations to pellet injection, the snowplow plasma gun has been studied as a fueling device. Based on current understanding of gun and plasma behavior a design is proposed, and its performance is predicted in a tokamak reactor environment

  7. Where have all the gun deaths gone?

    African Journals Online (AJOL)

    Gun violence denialists recently dismissed the findings of two studies presented at a seminar co-hosted by Gun Free South Africa, the. Institute for Security Studies and the African. Policing Civilian Oversight Forum. Abrahams et al.[1] compared the profile of female homicides from two representative national samples.

  8. Gun Control: The Debate and Public Policy.

    Science.gov (United States)

    Watkins, Christine

    1997-01-01

    Provides an overview and background information on the debate over gun control, as well as several teaching ideas. Handouts include a list of related topics drawn from various disciplines (economics, U.S. history), seven arguments for and against gun control, and a set of policy evaluation guidelines. (MJP)

  9. JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain.

    Science.gov (United States)

    Gao, Yong-Jing; Zhang, Ling; Samad, Omar Abdel; Suter, Marc R; Yasuhiko, Kawasaki; Xu, Zhen-Zhong; Park, Jong-Yeon; Lind, Anne-Li; Ma, Qiufu; Ji, Ru-Rong

    2009-04-01

    Our previous study showed that activation of c-jun-N-terminal kinase (JNK) in spinal astrocytes plays an important role in neuropathic pain sensitization. We further investigated how JNK regulates neuropathic pain. In cultured astrocytes, tumor necrosis factor alpha (TNF-alpha) transiently activated JNK via TNF receptor-1. Cytokine array indicated that the chemokine CCL2/MCP-1 (monocyte chemoattractant protein-1) was strongly induced by the TNF-alpha/JNK pathway. MCP-1 upregulation by TNF-alpha was dose dependently inhibited by the JNK inhibitors SP600125 (anthra[1,9-cd]pyrazol-6(2H)-one) and D-JNKI-1. Spinal injection of TNF-alpha produced JNK-dependent pain hypersensitivity and MCP-1 upregulation in the spinal cord. Furthermore, spinal nerve ligation (SNL) induced persistent neuropathic pain and MCP-1 upregulation in the spinal cord, and both were suppressed by D-JNKI-1. Remarkably, MCP-1 was primarily induced in spinal cord astrocytes after SNL. Spinal administration of MCP-1 neutralizing antibody attenuated neuropathic pain. Conversely, spinal application of MCP-1 induced heat hyperalgesia and phosphorylation of extracellular signal-regulated kinase in superficial spinal cord dorsal horn neurons, indicative of central sensitization (hyperactivity of dorsal horn neurons). Patch-clamp recordings in lamina II neurons of isolated spinal cord slices showed that MCP-1 not only enhanced spontaneous EPSCs but also potentiated NMDA- and AMPA-induced currents. Finally, the MCP-1 receptor CCR2 was expressed in neurons and some non-neuronal cells in the spinal cord. Together, we have revealed a previously unknown mechanism of MCP-1 induction and action. MCP-1 induction in astrocytes after JNK activation contributes to central sensitization and neuropathic pain facilitation by enhancing excitatory synaptic transmission. Inhibition of the JNK/MCP-1 pathway may provide a new therapy for neuropathic pain management.

  10. Cerebral damage caused by nail gun injury

    DEFF Research Database (Denmark)

    Andersen, Chris

    2016-01-01

    Background Accidents with nail guns are rather common, especially in the construction industry. Most injuries involve the extremities and several present with intracerebral injuries. When the patient is unconscious, it can be a big challenge to determine whether the injury is an accident, self....... The forensic examination showed lesions of intracranial surgery and minor bruises on the arms. No sign of defense injuries was found. There were no signs of malfunction of the nail gun-wielding robot. On the side of the machine, there were a handheld nail gun and the police investigated the case as a possible...... criminal act. They found bloodstains on the back of the machine. When awake, the man explained, that by accident, he had hit his head against a nail gun and as a result of this, the nail gun delivered a nail into his skull. Conclusion Sometimes, the circumstances of a case are not clear...

  11. New Electron Gun System for BEPCII

    CERN Document Server

    Liu, Bo; Long Chi, Yun; Zhang, Chuang

    2005-01-01

    The new electron gun system for BEPCII has been put into operation since Nov. 2004. The article describes the design, experiment and operation of this new system. The design current of the gun is 10 A for the pulse lengths of 1 ns, 2.5 ns and 1 μs with repetition rate of 50 Hz. The gun is operated with a pulsed high voltage power supply which can provide up to 200 kV high voltage. Computer simulations have been carried out in the design stage, including simulation of the gun geometry and beam transportation. Some important relation curves are obtained during the experiment. Two-bunch operation is available and some elementary tests have been performed. New scheme of the gun control system based on EPICS is also presented. The real operation shows that the design and manufacturing is basically successful.

  12. CHANGES IN MECHANICAL PROPERTIES OF MINIMALLY-PROCESSED YELLOW PITAHAYA TREATED WITH 1-MCP

    Directory of Open Access Journals (Sweden)

    LILIANA SERNA COCK

    2012-01-01

    Full Text Available Se evaluaron las propiedades mecánicas de esfuerzo del límite de fluencia (sL, modulo de deformación (Ed, esfuerzo de ruptura (sF, y deformación de Hencky en la ruptura (eHF de muestras de pitahaya amarilla mínimamente procesada y tratadas con 200 μgL-1 de 1-MCP durante el almacenamiento a 10±1 °C y 85% de humedad relativa. Las muestras fueron sometidas a pruebas de compresión uniaxial hasta la ruptura. Los resultados mostraron que las muestras tratadas con 1-MCP presentaron los mayores valores del esfuerzo del límite de fluencia, modulo de elasticidad y esfuerzo de ruptura. Esto indica que la aplicación del 1-MCP proporciona mayor firmeza a la fruta y puede representar una alternativa para disminuir cambios indeseables de textura durante el almacenamiento.

  13. The Ames Vertical Gun Range

    Science.gov (United States)

    Karcz, J. S.; Bowling, D.; Cornelison, C.; Parrish, A.; Perez, A.; Raiche, G.; Wiens, J.-P.

    2016-01-01

    The Ames Vertical Gun Range (AVGR) is a national facility for conducting laboratory- scale investigations of high-speed impact processes. It provides a set of light-gas, powder, and compressed gas guns capable of accelerating projectiles to speeds up to 7 km s(exp -1). The AVGR has a unique capability to vary the angle between the projectile-launch and gravity vectors between 0 and 90 deg. The target resides in a large chamber (diameter approximately 2.5 m) that can be held at vacuum or filled with an experiment-specific atmosphere. The chamber provides a number of viewing ports and feed-throughs for data, power, and fluids. Impacts are observed via high-speed digital cameras along with investigation-specific instrumentation, such as spectrometers. Use of the range is available via grant proposals through any Planetary Science Research Program element of the NASA Research Opportunities in Space and Earth Sciences (ROSES) calls. Exploratory experiments (one to two days) are additionally possible in order to develop a new proposal.

  14. Interpreting the empirical evidence on illegal gun market dynamics.

    Science.gov (United States)

    Braga, Anthony A; Wintemute, Garen J; Pierce, Glenn L; Cook, Philip J; Ridgeway, Greg

    2012-10-01

    Thousands of Americans are killed by gunfire each year, and hundreds of thousands more are injured or threatened with guns in robberies and assaults. The burden of gun violence in urban areas is particularly high. Critics suggest that the results of firearm trace data and gun trafficking investigation studies cannot be used to understand the illegal supply of guns to criminals and, therefore, that regulatory and enforcement efforts designed to disrupt illegal firearms markets are futile in addressing criminal access to firearms. In this paper, we present new data to address three key arguments used by skeptics to undermine research on illegal gun market dynamics. We find that criminals rely upon a diverse set of illegal diversion pathways to acquire guns, gun traffickers usually divert small numbers of guns, newer guns are diverted through close-to-retail diversions from legal firearms commerce, and that a diverse set of gun trafficking indicators are needed to identify and shut down gun trafficking pathways.

  15. Impact of MCP-1 and CCR-2 gene polymorphisms on coronary artery disease susceptibility.

    Science.gov (United States)

    Lin, Hsiu-Ling; Ueng, Kwo-Chang; Hsieh, Yih-Shou; Chiang, Whei-Ling; Yang, Shun-Fa; Chu, Shu-Chen

    2012-09-01

    Coronary artery disease (CAD) was the second leading cause of death during the last 3 years in Taiwan. Smooth muscle cells, monocytes/macrophages, and endothelial cells produce monocyte chemoattractant protein-1 (MCP-1) within atherosclerotic plaques following binding to the chemokine receptor-2 (CCR-2). Previous studies have well-documented the association between MCP-1 expression and susceptibility to, or clinicopathological features, of CAD. This study investigated the relationships between MCP-1-2518A/G and CCR-2-V64I genetic polymorphisms and CAD in the Taiwanese population. A total of 608 subjects, including 392 non-CAD controls and 216 patients with CAD, were recruited and subjected to polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to evaluate the effects of these two polymorphic variants on CAD. Results indicated a significant association between MCP-1 -2548 gene polymorphism and susceptibility to CAD. GG genotypes (OR = 1.629; 95 % CI = 1.003-2.644), or individuals with at least one G allele (OR = 1.511; 95 % CI = 1.006-2.270), had a higher risk of CAD as compared with AA genotypes. Results also revealed that subjects with at least one A allele of the V64I CCR2 gene polymorphism had significantly increased risk of CAD. G allele in MCP-1-2518 might contribute to higher prevalence of atrial fibrillation in CAD patients (OR = 4.254; p CCR-2 64I gene polymorphisms represent important factors in determining susceptibility to CAD, and the contribution of MCP-1-2518G could be through effects on atrial fibrillation in CAD patients.

  16. Reactive power compensating system

    Energy Technology Data Exchange (ETDEWEB)

    Williams, Timothy J. (Redondo Beach, CA); El-Sharkawi, Mohamed A. (Renton, WA); Venkata, Subrahmanyam S. (Seattle, WA)

    1987-01-01

    The reactive power of an induction machine is compensated by providing fixed capacitors on each phase line for the minimum compensation required, sensing the current on one line at the time its voltage crosses zero to determine the actual compensation required for each phase, and selecting switched capacitors on each line to provide the balance of the compensation required.

  17. MCP-1 Levels are Associated with Cardiac Remodeling but not with Resistant Hypertension.

    Science.gov (United States)

    Ritter, Alessandra Mileni Versuti; Faria, Ana Paula Cabral de; Sabbatini, Andrea; Corrêa, Nathalia Batista; Brunelli, Veridiana; Modolo, Rodrigo; Moreno, Heitor

    2017-04-01

    Hypertension is a chronic, low-grade inflammation process associated with the release of cytokines and development of target organ damage. Deregulated monocyte chemoattractant protein-1 (MCP-1) levels have been associated with high blood pressure and cardiovascular complications; however, the mechanisms involved are complex and not fully understood. This study aimed to compare the levels of MCP-1 in patients with resistant (RH) versus mild-to-moderate (HTN) hypertension and their association with the presence or absence of left ventricular hypertrophy (LVH) in all hypertensive subjects. We enrolled 256 hypertensive subjects: 120 RH and 136 HTN, investigating the relationship between circulating MCP-1 levels and blood pressure, biochemical data, hematologic profile, and cardiac damage within the RH and HTN groups. Plasma MCP-1 levels were measured by ELISA and LVH was assessed by echocardiography. We found no difference in MCP-1 levels between RH and HTN subjects. On the other hand, we encountered lower MCP-1 levels in patients with LVH (105 pg/mL [100 - 260 pg/mL] versus 136 pg/mL (100 - 200 pg/mL), p = 0.005, respectively] compared with those without LVH. A logistic regression model adjusted for body mass index (BMI), age, race, aldosterone levels, and presence of diabetes and RH demonstrated that median levels of MCP-1 (2.55 pg/mL [1.22 - 5.2 pg/mL], p = 0.01) were independently associated with LVH in the entire hypertensive population. Since MCP-1 levels were similar in both RH and HTN subjects and decreased in hypertensive patients with existing LVH, our study suggests a possible downregulation in MCP-1 levels in hypertensive individuals with LVH, regardless of hypertension strata. A hipertensão arterial é um processo crônico de baixo grau inflamatório, associado com liberação de citocinas e desenvolvimento de lesão em órgãos-alvo. A desregulação dos níveis de proteína quimiotática de monócitos-1 (MCP-1) tem sido associada com elevação da press

  18. Development of 10×10 Matrix-anode MCP-PMT

    Science.gov (United States)

    Yang, Jie; Li, Yongbin; Xu, Pengxiao; Zhao, Wenjin

    2018-02-01

    10×10 matrix-anode is developed by high-temperature co-fired ceramics (HTCC) technology. Based on the new matrix-anode, a new kind of photon counting imaging detector - 10×10 matrix-anode MCP-PMT is developed, and its performance parameters are tested. HTCC technology is suitable for the MCP-PMT's air impermeability and its baking process. Its response uniformity is better than the metal-ceramic or metal-glass sealing anode, and it is also a promising method to realize a higher density matrix-anode.

  19. A 30 ps Timing Resolution for Single Photons with Multi-pixel Burle MCP-PMT

    Energy Technology Data Exchange (ETDEWEB)

    Va' vra, J.; Benitez, J.; Coleman, J.; Leith, D.W.G.S.; Mazaheri, G.; Ratcliff, B.; Schwiening, J.; /SLAC

    2006-07-05

    We have achieved {approx}30 psec single-photoelectron and {approx}12ps for multi-photoelectron timing resolution with a new 64 pixel Burle MCP-PMT with 10 micron microchannel holes. We have also demonstrated that this detector works in a magnetic field of 15kG, and achieved a single-photoelectron timing resolution of better than 60 psec. The study is relevant for a new focusing DIRC RICH detector for particle identification at future Colliders such as the super B-factory or ILC, and for future TOF techniques. This study shows that a highly pixilated MCP-PMT can deliver excellent timing resolution.

  20. Gun Violence, Mental Illness, And Laws That Prohibit Gun Possession: Evidence From Two Florida Counties.

    Science.gov (United States)

    Swanson, Jeffrey W; Easter, Michele M; Robertson, Allison G; Swartz, Marvin S; Alanis-Hirsch, Kelly; Moseley, Daniel; Dion, Charles; Petrila, John

    2016-06-01

    Gun violence kills about ninety people every day in the United States, a toll measured in wasted and ruined lives and with an annual economic price tag exceeding $200 billion. Some policy makers suggest that reforming mental health care systems and improving point-of-purchase background checks to keep guns from mentally disturbed people will address the problem. Epidemiological research shows that serious mental illness contributes little to the risk of interpersonal violence but is a strong factor in suicide, which accounts for most firearm fatalities. Meanwhile, the effectiveness of gun restrictions focused on mental illness remains poorly understood. This article examines gun-related suicide and violent crime in people with serious mental illnesses, and whether legal restrictions on firearm sales to people with a history of mental health adjudication are effective in preventing gun violence. Among the study population in two large Florida counties, we found that 62 percent of violent gun crime arrests and 28 percent of gun suicides involved individuals not legally permitted to have a gun at the time. Suggested policy reforms include enacting risk-based gun removal laws and prohibiting guns from people involuntarily detained in short-term psychiatric hospitalizations. Project HOPE—The People-to-People Health Foundation, Inc.

  1. Gun Violence Following Inpatient Psychiatric Treatment: Offense Characteristics, Sources of Guns, and Number of Victims.

    Science.gov (United States)

    Kivisto, Aaron J

    2017-10-01

    This study presents data on the relative contribution to gun violence by people with a history of inpatient psychiatric treatment and on federal efforts to deter presumptively dangerous persons from obtaining firearms, information useful for analyzing the potential public health benefits of gun policies targeting people with serious mental illness. The study also estimates the reduction in gun violence victims that would be expected if individuals with a previous psychiatric hospitalization were prohibited from purchasing firearms. Data from 838 violent gun offenders from a nationally representative sample of state prison inmates were analyzed. Those with and without a history of psychiatric hospitalization were compared on a range of offense characteristics, including relationship to the victim, number of victims, location of the offense, and source of firearms. Inmates with a history of hospitalization constituted 12% of all violent gun offenders and accounted for 13% of the sample's victims. They were less likely than those without a previous hospitalization to victimize strangers (odds ratio=.52) and were no more likely to commit gun violence in public or to have multiple victims. Among those with previous hospitalizations, 78% obtained guns from sources not subject to federal background checks. Of the total 1,041 victims of gun violence, only 3% were victimized by participants with a history of hospitalization who obtained guns from currently regulated sources. Prohibiting all individuals with a history of psychiatric hospitalization from purchasing firearms, absent expanded background checks, was estimated to reduce the number of gun violence victims by only 3%.

  2. The design of an electron gun switchable between immersed and Brillouin flowa)

    Science.gov (United States)

    Becker, R.; Kester, O.

    2012-02-01

    An electron gun, which can be switched from immersed flow to Brillouin flow during operation, may have advantages for charge breeders as well as for electron beam ion sources and traps (EBISTs). For EBISTs this allows to change the current density according to the repetition frequency and charge state, for charge breeders and EBISTs a lower current density in immersed flow provides higher acceptance for injected ions, while the higher current density in Brillouin flow results in shorter breeding times and a lower emittance for the extracted beam. Therefore, we have designed such a gun for an EBIS with 5 T central magnetic field and without the use of iron and moving the gun. The gun was placed in the axial fringing field of the 5 T solenoid in such a position that a gate valve can be placed between the gun and the cryostat to allow for simple maintenance. The field at the cathode surface turned out to be only 0.05 T, which is not enough to focus 50 A/cm2 at a few kV. However, if a small normal conducting solenoid is placed over the vacuum tube in position of the gun, a field of 0.1 T may be obtained. With this the use of LaB6 as cathode material results in a magnetic compression of 44 and therewith in a focused current density in the trap region of more than 2000 A/cm2. By reversing the current in the gun solenoid the cathode field can easily compensated to zero. By proper design of the electrodes and the compression region, the gun will be able to deliver a beam in Brillouin flow. While this is interesting by itself - remember the "super-compression" reported on CRYEBIS-I - any magnetic field between zero and the value for immersed flow will result in an electron beam with a wide range of adjustable high current densities. The design tools used have been INTMAG(C) for the calculation of magnetic fields, EGN2(C) for the simulation of the gun and ANALYSE(C) for detailed analysis of the results (for more information see www.egun-igun.com).

  3. The design of an electron gun switchable between immersed and Brillouin flow.

    Science.gov (United States)

    Becker, R; Kester, O

    2012-02-01

    An electron gun, which can be switched from immersed flow to Brillouin flow during operation, may have advantages for charge breeders as well as for electron beam ion sources and traps (EBISTs). For EBISTs this allows to change the current density according to the repetition frequency and charge state, for charge breeders and EBISTs a lower current density in immersed flow provides higher acceptance for injected ions, while the higher current density in Brillouin flow results in shorter breeding times and a lower emittance for the extracted beam. Therefore, we have designed such a gun for an EBIS with 5 T central magnetic field and without the use of iron and moving the gun. The gun was placed in the axial fringing field of the 5 T solenoid in such a position that a gate valve can be placed between the gun and the cryostat to allow for simple maintenance. The field at the cathode surface turned out to be only 0.05 T, which is not enough to focus 50 A∕cm(2) at a few kV. However, if a small normal conducting solenoid is placed over the vacuum tube in position of the gun, a field of 0.1 T may be obtained. With this the use of LaB(6) as cathode material results in a magnetic compression of 44 and therewith in a focused current density in the trap region of more than 2000 A∕cm(2). By reversing the current in the gun solenoid the cathode field can easily compensated to zero. By proper design of the electrodes and the compression region, the gun will be able to deliver a beam in Brillouin flow. While this is interesting by itself--remember the "super-compression" reported on CRYEBIS-I--any magnetic field between zero and the value for immersed flow will result in an electron beam with a wide range of adjustable high current densities. The design tools used have been INTMAG(C) for the calculation of magnetic fields, EGN2(C) for the simulation of the gun and ANALYSE(C) for detailed analysis of the results (for more information see www.egun-igun.com).

  4. MCP/CCR2 signaling is essential for recruitment of mesenchymal progenitor cells during the early phase of fracture healing.

    Directory of Open Access Journals (Sweden)

    Masahiro Ishikawa

    Full Text Available OBJECTIVE: The purpose of this study was to investigate chemokine profiles and their functional roles in the early phase of fracture healing in mouse models. METHODS: The expression profiles of chemokines were examined during fracture healing in wild-type (WT mice using a polymerase chain reaction array and histological staining. The functional effect of monocyte chemotactic protein-1 (MCP-1 on primary mouse bone marrow stromal cells (mBMSCs was evaluated using an in vitro migration assay. MCP-1-/- and C-C chemokine receptor 2 (CCR2-/- mice were fractured and evaluated by histological staining and micro-computed tomography (micro-CT. RS102895, an antagonist of CCR2, was continuously administered in WT mice before or after rib fracture and evaluated by histological staining and micro-CT. Bone graft exchange models were created in WT and MCP-1-/- mice and were evaluated by histological staining and micro-CT. RESULTS: MCP-1 and MCP-3 expression in the early phase of fracture healing were up-regulated, and high levels of MCP-1 and MCP-3 protein expression observed in the periosteum and endosteum in the same period. MCP-1, but not MCP-3, increased migration of mBMSCs in a dose-dependent manner. Fracture healing in MCP-1-/- and CCR2-/- mice was delayed compared with WT mice on day 21. Administration of RS102895 in the early, but not in the late phase, caused delayed fracture healing. Transplantation of WT-derived graft into host MCP-1-/- mice significantly increased new bone formation in the bone graft exchange models. Furthermore, marked induction of MCP-1 expression in the periosteum and endosteum was observed around the WT-derived graft in the host MCP-1-/- mouse. Conversely, transplantation of MCP-1-/- mouse-derived grafts into host WT mice markedly decreased new bone formation. CONCLUSIONS: MCP-1/CCR2 signaling in the periosteum and endosteum is essential for the recruitment of mesenchymal progenitor cells in the early phase of fracture healing.

  5. One nanosecond pulsed electron gun systems

    International Nuclear Information System (INIS)

    Koontz, R.F.

    1979-02-01

    At SLAC there has been a continuous need for the injection of very short bunches of electrons into the accelerator. Several time-of-flight experiments have used bursts of short pulses during a normal 1.6 micro-second rf acceleration period. Single bunch beam loading experiments made use of a short pulse injection system which included high power transverse beam chopping equipment. Until the equipment described in this paper came on line, the basic grid-controlled gun pulse was limited to a rise time of 7 nanoseconds and a pulse width of 10 nanoseconds. The system described here has a grid-controlled rise time of less than 500 pico-seconds, and a minimum pulse width of less than 1 nanosecond. Pulse burst repetition rate has been demonstrated above 20 MHz during a 1.6 microsecond rf accelerating period. The order-of-magnitude increase in gun grid switching speed comes from a new gun design which minimizes lead inductance and stray capacitance, and also increases gun grid transconductance. These gun improvements coupled with a newly designed fast pulser mounted directly within the gun envelope make possible subnanosecond pulsing of the gun

  6. Gun Violence, mental health, and Connecticut physicians.

    Science.gov (United States)

    Dodds, Peter R; Anderson, Caitlyn O; Dodds, Jon H

    2014-01-01

    While there is a public perception that gun violence is associated with mental illness we present evidence that it is a complex public health problem which defies simple characterizations and solutions. Only a small percentage of individuals with mental illness are at risk for extreme violence and they account for only a small percentage of gun-related homicides. Individuals who are at risk for gun violence are difficult to identify and successfully treat. The incidence, and perhaps the demographics, of gun violence vary substantially from state to state. We make a case for Connecticut physicians to study gun violence at the state level. We recommend that Connecticut physicians promote and expand upon the American Academy of Pediatrics' recommendation for creating a "safe home environment. "We suggest that guns be secured in all homes in which there are children. In addition we suggest that guns be voluntarily removed from homes in which there are individuals with a history of violence, threats of violence, depression, drug and/or alcohol abuse, and individuals with major mental illnesses who are not cooperating with therapy.

  7. Design of the BEPCII electron gun system

    International Nuclear Information System (INIS)

    Liu Bo; Gu Mengping; Chi Yunlong

    2006-01-01

    BEPCII upgrading project needs a new high current electron gun. The design stage such as physical design, mechanical design and control system design of this new electron gun is described. The emission current is designed to be higher than 10 A for the pulse width of 1 ns with repetition rate of 50 Hz. The gun will operate with a pulsed high voltage power supply which can provide up to 200 kV high voltage. Computer simulations and optimizations have been carried out in the design stage, including the gun geometry and beam transport. EGUN and DGUN codes are used to simulate the gun geometry, and the results show that the perveance is about 0.22 μA·V -3/2 , and the emittance at gun exit is about 16 π·mm·mrad. PARMELA code shows that the electron beam can be easily transported to the end of the first accelerating tube with a capture efficiency of 67% and root mean square emittance of 25 mm·mrad. New scheme of the gun control system based on EPICS is also presented. Two-bunch operation mode and 2.5 μs long pulse operation mode are available in the control system. (authors)

  8. Simple light gas guns for hypervelocity studies

    International Nuclear Information System (INIS)

    Combs, S.K.; Haselton, H.H.; Milora, S.L.

    1990-01-01

    Two-stage light guns are used extensively in hypervelocity research. The applications of this technology include impact studies and special materials development. Oak Ridge National Laboratory (ORNL) has developed two-stage guns that accelerate small projectiles (4-mm nominal diameter) to velocities of up to ∼5 km/s. These guns are relatively small and simple (thus, easy to operate), allowing a significant number of test shots to be carried out and data accumulated in a short time. Materials that have been used for projectiles include plastics, frozen isotopes of hydrogen, and lithium hydride. One gun has been used to demonstrate repetitive operation at a rate of 0.7 Hz; and, with a few design improvements, it appears capable of performing at firing frequencies of 1--2 Hz. A schematic of ORNL two-stage device is shown below. Unlike most such devices, no rupture disks are used. Instead, a fast valve (high-flow type) initiates the acceleration process in the first stage. Projectiles can be loaded into the gun breech via the slide mechanism; this action has been automated which allows repetitive firing. Alternatively, the device is equipped with ''pipe gun'' apparatus in which gas can be frozen in situ in the gun barrel to form the projectile. This equipment operates with high reliability and is well suited for small-scale testing at high velocity. 17 refs., 6 figs., 2 tabs

  9. Extended suicide using an atypical stud gun.

    Science.gov (United States)

    Hagemeier, L; Schyma, C; Madea, B

    2009-08-10

    Suicides with stud guns are uncommon, but are well documented in the literature. On rare occasions, stud guns are also used as a homicide weapon. This case report describes an extended suicide in which a husband killed his wife and their two dogs, which lived on the property. The husband then committed suicide with a shot from the stud gun into his skull. He was a 70-year-old pensioner, a retired butcher, who was found by his son. He was lying in a supine position on a carpet in the living room, with the stud gun stuck in his skull. During autopsy, high concentrations of an antihistamine were found in the blood of each corpse; this drug is used as a soporific. In contrast to the literature, which mainly describes powder deposits due to the use of conventional stud guns, in this case a stud gun was used in which the expanding gases and powder escaped together with the central bolt at the front of the device; powder drains were not involved. Detailed findings of the autopsy are given with reference to this type of stud gun.

  10. Alignment Fixtures For Vacuum-Plasma-Spray Gun

    Science.gov (United States)

    Woodford, William H.; Mckechnie, Timothy N.; Power, Christopher A.; Daniel, Ronald L., Jr.

    1993-01-01

    Fixtures for alignment of vacuum-plasma-spray guns built. Each fixture designed to fit specific gun and holds small, battery-powered laser on centerline of gun. Laser beam projects small red dot where centerline intersects surface of workpiece to be sprayed. After laser beam positioned on surface of workpiece, fixture removed from gun and spraying proceeds.

  11. Gun Safety Management with Patients at Risk for Suicide

    Science.gov (United States)

    Simon, Robert I.

    2007-01-01

    Guns in the home are associated with a five-fold increase in suicide. All patients at risk for suicide must be asked if guns are available at home or easily accessible elsewhere, or if they have intent to buy or purchase a gun. Gun safety management requires a collaborative team approach including the clinician, patient, and designated person…

  12. Ready, Fire, Aim: The College Campus Gun Fight

    Science.gov (United States)

    Birnbaum, Robert

    2013-01-01

    The question of whether guns should be permitted on college and university campuses in the United States reflects the tension between two competing perspectives. America has both a robust gun culture and an equally robust (if less well known) gun-control culture. The gun culture is as American as apple pie: There may be as many as 300 million…

  13. DC photoemission electron guns as ERL sources

    International Nuclear Information System (INIS)

    Sinclair, Charles K.

    2006-01-01

    Very-high-voltage DC electron guns, delivering moderate duration bunches from photoemission cathodes, and followed by conventional drift bunching and acceleration, offer a practical solution for an ERL injector. In a variant of this scheme, a DC gun is placed in close proximity to a superconducting RF accelerator cavity, with few or no active elements between the gun and cavity. The principal technical challenge with such electron guns arises from field emission from the cathode electrode and its support structure. Field emission may result in voltage breakdown across the cathode-anode gap, or a punch-through failure of the insulator holding off the cathode potential, as well as lesser though still serious problems. Various means to mitigate these problems are described. The operational lifetime of high quantum efficiency photocathodes in these guns is determined by the vacuum conditions, through phenomena such as chemical poisoning and ion back-bombardment. Minimization of the field strength on electrode structures pushes high-voltage DC guns toward large dimensions and, correspondingly, large outgassing loads, but it is also true that these guns offer many opportunities for achieving excellent vacuum conditions. Good solutions to vacuum problems that had previously limited cathode lifetime have been demonstrated in recent years. Designs for DC guns presently in use and planned for the near future will be described. The parameters necessary for a 100 mA average current, very-high-voltage DC gun with a photocathode operational lifetime greater than 100 h appear to be within reach, but have yet to be demonstrated. A 1 A average current source with good cathode operational lifetime will require developments beyond the present state-of-the-art

  14. Design and development of a pierce electron gun

    International Nuclear Information System (INIS)

    Bhattacharjee, D.; Tiwari, R.; Nayak, B.; Tillu, A.R.; Jayaprakash, D.; Mishra, R.L.; Mittal, K.C.; Chakravarthy, D.P.; Gantayet, L.M.

    2011-01-01

    An electron gun is designed and developed using the Pierce configuration for the focusing electrode. Simulations were carried out using CST Particle Studio. The Gun is a thermionic type electron gun with indirect heating of the LaB6 cathode. The gun is capable of delivering a beam current of 500 mA at 50 kV with a beam size of less than 3.5 mm. It was tested on the gun test bench. This paper presents the gun design, particle simulations study, testing of the gun on test bench and integration with the ECIL 9 MeV linac. (author)

  15. Evaluation of Smart Gun Technologies preliminary report

    Energy Technology Data Exchange (ETDEWEB)

    Weiss, D.R.

    1996-01-01

    The Smart Gun Technology Project has a goal to eliminate the capability of an unauthorized user from firing a law enforcement officer`s firearm by implementing {open_quote}smart{close_quote} technologies. Smart technologies are those that can in some manner identify an officer. This report will identify, describe, and grade various technologies as compared to the requirements that were obtained from officers. This report does not make a final recommendation for a smart gun technology, nor does it give the complete design of a smart gun system.

  16. Field reversal produced by a plasma gun

    International Nuclear Information System (INIS)

    Hartman, C.W.; Condit, W.; Granneman, E.H.A.; Prono, D.; Smith, A.C. Jr.; Taska, J.; Turner, W.C.

    1980-01-01

    Experimental results are presented of the production of Field-Reversed Plasma with a high energy coaxial plasma gun. The gun is magnetized with solenoids inside the center electrode and outside the outer electrode so that plasma emerging from the gun entrains the radial fringer field at the muzzle. The plasma flow extends field lines propagating a high electrical conductivity, the flux inside the center electrode should be preserved. However, for low flux, the trapped flux exceeds by 2 or more the initial flux, possibly because of helical deformation of the current channel extending from the center electrode

  17. Performance of the Brookhaven photocathode rf gun

    International Nuclear Information System (INIS)

    Batchelor, K.; Ben-Zvi, I.; Fernow, R.C.; Fischer, J.; Fisher, A.S.; Gallardo, J.; Ingold, G.; Kirk, H.G.; Leung, K.P.; Malone, R.; Pogorelsky, I.; Srinivasan-Rao, T.; Rogers, J.; Tsang, T.; Sheehan, J.; Ulc, S.; Woodle, M.; Xie, J.; Zhang, R.S.; Lin, L.Y.; McDonald, K.T.; Russell, D.P.; Hung, C.M.; Wang, X.J.

    1991-01-01

    The Brookhaven Accelerator Test Facility (ATF) uses a photocathode rf gun to provide a high-brightness electron beam intended for FEL and laser-acceleration experiments. The rf gun consists of 1 1/2 cells driven at 2856 MHz in π-mode with a maximum cathode field of 100 MV/m. To achieve long lifetimes, the photocathode development concentrates on robust metals such as copper, yttrium and samarium. We illuminate these cathodes with a 10-ps, frequency-quadrupled Nd:YAG laser. We describe the initial operation of the gun, including measurements of transverse and longitudinal emittance, quantum efficiencies, and peak current. The results are compared to models

  18. Beam emittance measurement from CERN thermionic guns

    International Nuclear Information System (INIS)

    Kester, O.; Rao, R.; Rinolfi, L.

    1992-01-01

    In the LEP Injector Linacs (LIL) a thermionic gun provides electron beams with different peak intensities at an energy of 80 keV. The beam emittances were estimated from the EGUN programme. Since the gun is of triode type, the main contribution to the emittance comes from the grid. The simulation programme does not model the real geometry by assuming a cylindrical symmetry, while the grid does not have such symmetry. A Gun Test Facility (GTF), allowing emittance measurements, based on the 3-gradients-method was installed. The experimental results are presented. (author) 6 refs.; 6 figs

  19. Alpha Fuels Environmental Test Facility impact gun

    International Nuclear Information System (INIS)

    Anderson, C.G.

    1978-01-01

    The Alpha Fuels Environmental Test Facility (AFETF) impact gun is a unique tool for impact testing 238 PuO 2 -fueled heat sources of up to 178-mm dia at velocities to 300 m/s. An environmentally-sealed vacuum chamber at the muzzle of the gun allows preheating of the projectile to 1,000 0 C. Immediately prior to impact, the heat source projectile is completely sealed in a vacuum-tight catching container to prevent escape of its radioactive contents should rupture occur. The impact velocity delivered by this gas-powered gun can be regulated to within +-2%

  20. Advances in DC photocathode electron guns

    International Nuclear Information System (INIS)

    Dunham M, Bruce; Heartmann, P.; Reza Kazimi; Hongxiu Liu; Poelker, B.M.; Price, J.S.; Rutt, P.M.; Schneider, W.J.; Sinclair K, Charles

    1998-01-01

    At Jefferson Lab, a DC photoemission gun using GaAs and GaAs-like cathodes provides a source of polarized electrons for the main accelerator. The gun is required to produce high average current with long operational lifetimes and high system throughout. Recent work has shown that careful control of the parameters affecting cathode lifetime lead to dramatic improvements in source operation. These conditions include vacuum and the related effect of ion back-bombardment, and precise control of all of the electrons emitted from the cathode. In this paper, the authors will review recent results and discuss implications for future photocathode guns

  1. Advances in DC photocathode electron guns

    International Nuclear Information System (INIS)

    Dunham, B. M.; Hartmann, P.; Kazimi, R.; Liu, H.; Poelker, B. M.; Price, J. S.; Rutt, P. M.; Schneider, W. J.; Sinclair, C. K.

    1999-01-01

    At Jefferson Lab, a DC photoemission gun using GaAs and GaAs-like cathodes provides a source of polarized electrons for the main accelerator. The gun is required to produce high average current with long operational lifetimes and high system throughput. Recent work has shown that careful control of the parameters affecting cathode lifetime lead to dramatic improvements in source operation. These conditions include vacuum and the related effect of ion backbombardment, and precise control of all of the electrons emitted from the cathode. In this paper, we will review recent results and discuss implications for future photocathode guns

  2. Advances in DC photocathode electron guns

    International Nuclear Information System (INIS)

    Dunham, B.M.; Hartmann, P.; Kazimi, R.; Liu, H.; Poelker, B.M.; Price, J.S.; Rutt, P.M.; Schneider, W.J.; Sinclair, C.K.

    1999-01-01

    At Jefferson Lab, a DC photoemission gun using GaAs and GaAs-like cathodes provides a source of polarized electrons for the main accelerator. The gun is required to produce high average current with long operational lifetimes and high system throughput. Recent work has shown that careful control of the parameters affecting cathode lifetime lead to dramatic improvements in source operation. These conditions include vacuum and the related effect of ion backbombardment, and precise control of all of the electrons emitted from the cathode. In this paper, we will review recent results and discuss implications for future photocathode guns. copyright 1999 American Institute of Physics

  3. "Is there a gun in the home?" Assessing the risks of gun ownership in older adults.

    Science.gov (United States)

    Pinholt, Ellen M; Mitchell, Joshua D; Butler, Jane H; Kumar, Harjinder

    2014-06-01

    An important ethical and safety concern that geriatricians, primary care providers, and home health professionals need to address is gun ownership by elderly adults. Those aged 65 and older now have the highest rate of gun ownership in America, and they also have a high prevalence of depression and suicide. Dementia can add additional layers of risk. Even older gun owners who are otherwise intellectually intact may benefit from information about gun safety with the increasing numbers of children being cared for by grandparents. Health professionals should ask patients, "Is there a gun in the home?" in the clinic and during home visits. Healthcare professionals must have knowledge and skills to address safe gun ownership in elderly adults. The 5 L's (Locked, Loaded, Little children, feeling Low, Learned owner) will assist professionals in addressing all aspects of safe ownership. © 2014, Copyright the Authors Journal compilation © 2014, The American Geriatrics Society.

  4. Camouflaged Collectives: Managing Stigma and Identity at Gun Events

    Directory of Open Access Journals (Sweden)

    Sarah Jane Blithe

    2017-02-01

    Full Text Available Gun violence persists in the United States, claiming lives and escalating healthcare costs. This article seeks to contribute to social justice work on the “gun problem” by studying gun collectives. To understand gun culture and to identify gun violence reduction strategies, we study places where gun owners organize – legal (and sometimes illegal settings that facilitate dialogue about gun issues. Based on participant observation and collaborative event ethnography at gun shows and a private shooting party, this analysis presents findings about the practices gun collective members use to manage stigma. We conclude that when participants in gun events attempt to subvert core stigma through everyday stigma management practices, they effectively facilitate the unfettered exchange of potentially dangerous goods, promote the invisibility of oppressive structures, and normalize violence.

  5. MCP characterization at the Cu and Mo Kα x-ray energies

    International Nuclear Information System (INIS)

    Walsh, P.J.; Evans, S.; Schappert, G.T.; Kyrala, G.A.

    1998-03-01

    The authors are investigating the usefulness of microchannel plate (MCP) intensifiers for imaging x-rays at high photon energies, specifically by using filtered X-rays from an electron bombardment source to generate the K α lines of Cu at 8.04 KeV and Mo at 17.5 KeV. These high energy lines are used to measure the resolution of an MCP based intensifier produced at Los Alamos National Laboratory. They have investigated the spot size of a fielded MCP intensifier by observing, on film, the result of single photon excitation of microchannels. Measurement of the spot size was done with visible light microscopy. They report initial results of the spot size distribution in the stripline direction. They have also begun a measurement of the azimuthal anisotropy in the spatial resolution, accentuated at these energies by the inclination of the axis of the MCP channels. They concentrate on an actual ''fielded instrument'' resolution, rather than ideal, for the purpose of analyzing image data captured at the NOVA Laser Facility

  6. Use of equimolar cysteine/ascorbic acids to recover MCP synthesized Ti(Mg) alloy

    CSIR Research Space (South Africa)

    Mushove, T

    2010-10-01

    Full Text Available Dissolution of waste by-products of mechanochemical processing (MCP) synthesis of Ti(Mg) alloy, from TiO2 and 15 wt.% excess Mg, was conducted in equimolar cysteine/ascorbic acids. The synthesized alloy is inherently mixed with MgO and other oxides...

  7. 'Diffuse skin browning' in 1-MCP-treated apples: etiology and systems of control.

    Science.gov (United States)

    Larrigaudière, Christian; Vilaplana, Rosa; Recasens, Inmaculada; Soria, Yolanda; Dupille, Eve

    2010-11-01

    'Diffuse skin browning' (DSB) is a physiological disorder that affects Golden Delicious apples treated with 1-methylcyclopropene (1-MCP). Although a very high incidence is found, very little is known about the etiology of this disorder. This study aims to provide an understanding of the causes of this disorder and prevent it. A very high incidence of DSB was found in 1-MCP-treated apples independent of the location of the orchard. Similar to superficial scald, harvest maturity determines the DSB incidence, with the more mature fruit being less sensitive. The 1-MCP dose (156 nL L(-1) or 625 nL L(-1)) and the temperature at which the 1-MCP treatment was applied (0.5 or 20 °C) did not affect the incidence of DSB. Diphenylamine (DPA) treatment did not prevent DSB, contrary to superficial scald. Additionally, controlled atmosphere storage only partially reduced the incidence of DSB, whereas progressive cooling strategies completely inhibited DSB occurrence. A direct correlation was found between the sensitivity of the Golden Delicious clone to russeting and its sensitivity to develop DSB during storage. Our results indicated that DSB and superficial scald are two different disorders involving different oxidative processes. DSB can be prevented by progressive cooling and selection of russeting-resistant clones. 2010 Society of Chemical Industry

  8. 77 FR 37834 - Revocation of Certain Requirements Pertaining to Caps Intended for Use With Toy Guns and Toy Guns...

    Science.gov (United States)

    2012-06-25

    ... Certain Requirements Pertaining to Caps Intended for Use With Toy Guns and Toy Guns Not Intended for Use With Caps AGENCY: Consumer Product Safety Commission. ACTION: Notice of proposed rulemaking. SUMMARY... compliance than our existing regulations pertaining to caps intended for use with toy guns and toy guns not...

  9. Optimization of the electron collection efficiency of a large area MCP-PMT for the JUNO experiment

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Lin, E-mail: chenlin@opt.cn [State Key Laboratory of Transient Optics and Photonics, Xi’an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi’an 710119 (China); Graduate School of Chinese Academy of Sciences (CAS), Beijing 100049 (China); Xi’an Jiaotong University, Xi’an 710049 (China); Tian, Jinshou [Graduate School of Chinese Academy of Sciences (CAS), Beijing 100049 (China); Liu, Chunliang [Xi’an Jiaotong University, Xi’an 710049 (China); Wang, Yifang; Zhao, Tianchi [Institute of High Energy Physics (IHEP) of CAS, Beijing 100049 (China); Liu, Hulin; Wei, Yonglin; Sai, Xiaofeng [Graduate School of Chinese Academy of Sciences (CAS), Beijing 100049 (China); Chen, Ping [State Key Laboratory of Transient Optics and Photonics, Xi’an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi’an 710119 (China); Graduate School of Chinese Academy of Sciences (CAS), Beijing 100049 (China); Wang, Xing; Lu, Yu [Graduate School of Chinese Academy of Sciences (CAS), Beijing 100049 (China); Hui, Dandan; Guo, Lehui [State Key Laboratory of Transient Optics and Photonics, Xi’an Institute of Optics and Precision Mechanics (XIOPM), Chinese Academy of Sciences (CAS), Xi’an 710119 (China); Graduate School of Chinese Academy of Sciences (CAS), Beijing 100049 (China); Liu, Shulin; Qian, Sen; Xia, Jingkai; Yan, Baojun; Zhu, Na [Institute of High Energy Physics (IHEP) of CAS, Beijing 100049 (China); Sun, Jianning; Si, Shuguang [North Night Vision Technology (NNVT) CO., LTD, Nanjing 210110 (China); and others

    2016-08-11

    A novel large-area (20-inch) photomultiplier tube based on microchannel plate (MCP-PMTs) is proposed for the Jiangmen Underground Neutrino Observatory (JUNO) experiment. Its photoelectron collection efficiency C{sub e} is limited by the MCP open area fraction (A{sub open}). This efficiency is studied as a function of the angular (θ), energy (E) distributions of electrons in the input charge cloud and the potential difference (U) between the PMT photocathode and the MCP input surface, considering secondary electron emission from the MCP input electrode. In CST Studio Suite, Finite Integral Technique and Monte Carlo method are combined to investigate the dependence of C{sub e} on θ, E and U. Results predict that C{sub e} can exceed A{sub open}, and are applied to optimize the structure and operational parameters of the 20-inch MCP-PMT prototype. C{sub e} of the optimized MCP-PMT is expected to reach 81.2%. Finally, the reduction of the penetration depth of the MCP input electrode layer and the deposition of a high secondary electron yield material on the MCP are proposed to further optimize C{sub e}.

  10. Influence of 1-MCP treatments on eating quality and consumer preferences of ‘Qinmei’ kiwifruit during shelf life

    Science.gov (United States)

    Consumers and growers in China sometime complain that Kiwifruits treated with an ethylene action inhibitor 1-MCP are difficult to ripen and show poor eating quality. This study addresses the quality parameters affecting consumer preferences and reevaluates the necessity of 1-MCP application for stor...

  11. Optimization of the electron collection efficiency of a large area MCP-PMT for the JUNO experiment

    International Nuclear Information System (INIS)

    Chen, Lin; Tian, Jinshou; Liu, Chunliang; Wang, Yifang; Zhao, Tianchi; Liu, Hulin; Wei, Yonglin; Sai, Xiaofeng; Chen, Ping; Wang, Xing; Lu, Yu; Hui, Dandan; Guo, Lehui; Liu, Shulin; Qian, Sen; Xia, Jingkai; Yan, Baojun; Zhu, Na; Sun, Jianning; Si, Shuguang

    2016-01-01

    A novel large-area (20-inch) photomultiplier tube based on microchannel plate (MCP-PMTs) is proposed for the Jiangmen Underground Neutrino Observatory (JUNO) experiment. Its photoelectron collection efficiency C e is limited by the MCP open area fraction (A open ). This efficiency is studied as a function of the angular (θ), energy (E) distributions of electrons in the input charge cloud and the potential difference (U) between the PMT photocathode and the MCP input surface, considering secondary electron emission from the MCP input electrode. In CST Studio Suite, Finite Integral Technique and Monte Carlo method are combined to investigate the dependence of C e on θ, E and U. Results predict that C e can exceed A open , and are applied to optimize the structure and operational parameters of the 20-inch MCP-PMT prototype. C e of the optimized MCP-PMT is expected to reach 81.2%. Finally, the reduction of the penetration depth of the MCP input electrode layer and the deposition of a high secondary electron yield material on the MCP are proposed to further optimize C e .

  12. Rail gun powered by an integral explosive generator

    International Nuclear Information System (INIS)

    Peterson, D.R.; Fowler, C.M.

    1979-01-01

    We propose the use of a rail gun powered by an explosive magnetic flux compression generator built into the rail gun itself in which the rails of the gun are driven together behind the projectile by explosives. The magnetic field established between the rails by an initial current supplied by an external source at the breech of the gun is trapped and compressed by the collapsing rails to accelerate the projectile down the bore of the gun

  13. Stereotactic breast biopsy with a biopsy gun

    International Nuclear Information System (INIS)

    Parker, S.H.; Lovin, J.; Luethke, J.; Jobe, W.E.; Hopper, K.D.; Yakes, W.F.

    1989-01-01

    With the recent introduction of stereotactic mammographic localizing devices, the authors have been performing histologic core needle breast biopsies in which the Bard biopsy gun is used in conjunction with sterotactic guidance. The authors have performed 60 breast gun biopsies with 16-gauge and 18-gauge biopsy-cut needles. These biopsies were followed immediately by traditional surgical excision. Pathologic results correlated well in 52 of the 60 patients, including 10 of 13 cancers. Three of the eight negative correlations occurred when diagnosis was made on gun biopsy but not on surgical biopsy. The stereotactic- guided gun biopsies appear to approach the surgical gold standard, decrease patient discomfort and potential disfigurement, lower the cost of breast biopsy, and lower the threshold necessary to perform breast biopsy

  14. RF Electron Gun with Driven Plasma Cathode

    CERN Document Server

    Khodak, Igor

    2005-01-01

    It's known that RF guns with plasma cathodes based on solid-state dielectrics are able to generate an intense electron beam. In this paper we describe results of experimental investigation of the single cavity S-band RF gun with driven plasma cathode. The experimental sample of the cathode based on ferroelectric ceramics has been designed. Special design of the cathode permits to separate spatially processes of plasma development and electron acceleration. It has been obtained at RF gun output electron beam with particle energy ~500 keV, pulse current of 4 A and pulse duration of 80 ns. Results of experimental study of beam parameters are referred in. The gun is purposed to be applied as the intense electron beam source for electron linacs.

  15. Electro Thermal Chemical Gun Technology Study

    National Research Council Canada - National Science Library

    Diamond, P

    1999-01-01

    .... Michael Stroscio. Electro Thermal Chemical (ETC) gun technology refers to the use of plasma devices in place of traditional chemical ignitors to initiate the burning of high energy propellants in a controlled manner...

  16. Uudised : Guns N' Roses Soomes. Valmis ulmeraadio

    Index Scriptorium Estoniae

    2006-01-01

    Ameerika hard-rock-bändi Guns N' Roses kontserdist 5. juulil Hartwall Areenal Soomes. Kord kuus on Ulmeplaatide kodulehekülel www. ulmeplaadid.ee võimalus kuulata ulmeraadiot, kus esitusel eesti kergemuusika

  17. Prestressed Carbon Fiber Composite Overwrapped Gun Tube

    National Research Council Canada - National Science Library

    Littlefield, Andrew; Hyland, Edward

    2006-01-01

    .... Using composite materials not only directly removes weight from the gun tube but, by better balancing the tube, allows the use of smaller drive systems, thus further enhancing the system weight loss...

  18. Ballistic Rail Gun Soft Recovery Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Ballistic Rail Gun Soft Recovery Facility accommodates a 155mm Howitzer, fired horizontally into a 104-foot long water trough to slow the projectile and recover...

  19. Arc Plasma Gun With Coaxial Powder Feed

    Science.gov (United States)

    Zaplatynsky, Isidor

    1988-01-01

    Redesigned plasma gun provides improved metallic and ceramic coatings. Particles injected directly through coaxial bore in cathode into central region of plasma jet. Introduced into hotter and faster region of plasma jet.

  20. Mass Shootings, Mental Illness, and Gun Control.

    Science.gov (United States)

    Philpott-Jones, Sean

    2018-03-01

    In the wake of the Stoneman Douglas School shooting, Republican and Democratic leaders-like the American electorate they represent-remain sharply divided in their responses to gun violence. They are united in their condemnation of these mass shootings, but they disagree about whether stricter or looser gun control laws are the answer. Those on the right side of the political aisle suggest that the issue is one of mental illness rather than gun control. Conversely, those who are more liberal or progressive in their political learnings are quick to condemn attempts to reframe the issue of mass shootings as a mental health problem. Both sides are wrong. Mass shootings are indeed partially a mental health problem, albeit one poorly addressed by our current laws and policies. But the solution to mass shootings also needs to consider strategies that may reduce gun violence in general. © 2018 The Hastings Center.

  1. Emittance measurement and optimization for the photocathode RF gun with laser profile shaping

    International Nuclear Information System (INIS)

    Liu Shengguang; Masafumi Fukuda; Sakae Araki; Nobuhiro Terunuma; Junji Urakawa

    2010-01-01

    The Laser Undulator Compact X-ray source (LUCX) is a test bench for a compact high brightness X-ray generator, based on inverse Compton Scattering at KEK, which requires high intensity multi-bunch trains with low transverse emittance. A photocathode RF gun with emittance compensation solenoid is used as an electron source. Much endeavor has been made to increase the beam intensity in the multi-bunch trains. The cavity of the RF gun is tuned into an unbalanced field in order to reduce space charge effects, so that the field gradient on the cathode surface is relatively higher when the forward RF power into gun cavity is not high enough. A laser profile shaper is employed to convert the driving laser profile from Gaussian into uniform. In this research we seek to find the optimized operational conditions for the decrease of the transverse emittance. With the uniform driving laser and the unbalanced RF gun, the RMS transverse emittance of a 1 nC bunch has been improved effectively from 5.46 πmm.mrad to 3.66 πmm·mrad. (authors)

  2. Gun Trafficking and the Southwest Border

    Science.gov (United States)

    2009-07-29

    felons, drug traffickers, and juvenile gang members from acquiring firearms from gun traffickers. These criminals often acquire firearms from persons...renounced their U.S. citizenship; (8) persons restrained under a court-order from harassing, stalking , or threatening an intimate partner or child of... gang members from acquiring firearms from gun traffickers. These criminals often acquire firearms from a person who otherwise is not prohibited to

  3. Conference on electromagnetic guns and launchers, 1980

    International Nuclear Information System (INIS)

    Anon.

    1982-01-01

    Proceedings includes 31 papers dealing with the physical principles and engineering technology associated with the development of electromagnetic propulsion, with emphasis on its use for guns, launchers as well as other military equipment. Topics covered include: rail guns, projectiles, mass accelerators, electric motors and generators, nuclear reactors, superconducting devices, plasma acceleration and confinement, traveling magnetic waves, aerospace propulsion, space shuttles, homopolar generators, fusion reactors, tokamaks, impact fusion, and electric power generation. All papers are abstracted and indexed separately

  4. Modifications Of A Commercial Spray Gun

    Science.gov (United States)

    Allen, Peter B.

    1993-01-01

    Commercial spray gun modified to increase spray rate and make sprayed coats more nearly uniform. Consists of gun head and pneumatic actuator. Actuator opens valves for two chemical components, called "A" and "B," that react to produce foam. Components flow through orifices, into mixing chamber in head. Mixture then flows through control orifice to spray tip. New spray tip tapered to reduce area available for accumulation of foam and makes tip easier to clean.

  5. On the frequency scalings of RF guns

    International Nuclear Information System (INIS)

    Lin, L.C.; Chen, S.C.; Wurtele, J.S.

    1995-01-01

    A frequency scaling law for RF guns is derived from the normalized Vlasov-Maxwell equations. It shows that higher frequency RF guns can generate higher brightness beams under the assumption that the accelerating gradient and all beam and structure parameters are scaled with the RF frequency. Numerical simulation results using MAGIC confirm the scaling law. A discussion of the range of applicability of the law is presented. copyright 1995 American Institute of Physics

  6. The Impact of Banning Juvenile Gun Possession.

    OpenAIRE

    Marvell, Thomas B

    2001-01-01

    A 1994 federal law bans possession of handguns by persons under 18 years of age. Also in 1994, 11 states passed their own juvenile gun possession bans. Eighteen states had previously passed bans, 15 of them between 1975 and 1993. These laws were intended to reduce homicides, but arguments can be made that they have no effect on or that they even increase the homicide rate. This paper estimates the laws' impacts on various crime measures, primarily juvenile gun homicide victimizations and suic...

  7. Electrothermal plasma gun as a pellet injector

    International Nuclear Information System (INIS)

    Kincaid, R.W.; Bourham, M.A.

    1994-01-01

    The NCSU electrothermal plasma gun SIRENS has been used to accelerate plastic (Lexan polycarbonate) pellets, to determine the feasibility of the use of electrothermal guns as pellet injectors. The use of an electrothermal gun to inject frozen hydrogenic pellets requires a mechanism to provide protective shells (sabots) for shielding the pellet from ablation during acceleration into and through the barrel of the gun. The gun has been modified to accommodate acceleration of the plastic pellets using special acceleration barrels equipped with diagnostics for velocity and position of the pellet, and targets to absorb the pellet's energy on impact. The length of the acceleration path could be varied between 15 and 45 cm. The discharge energy of the electrothermal gun ranged from 2 to 6 kJ. The pellet velocities have been measured via a set of break wires. Pellet masses were varied between 0.5 and 1.0 grams. Preliminary results on 0.5 and 1.0 g pellets show that the exit velocity reaches 0.9 km/s at 6 kJ input energy to the source. Higher velocities of 1.5 and 2.7 km/s have been achieved using 0.5 and 1.0 gm pellets in 30 cm long barrel, without cleaning the barrel between the shots

  8. Electron gun for the Fel Clio

    International Nuclear Information System (INIS)

    Chaput, R.

    1990-01-01

    A triode electron gun has been developed and manufactured at LURE (Laboratoire pour l'Utilisation du Rayonnement Electromagnetique) and LAL (Laboratoire de l'Accelerateur Lineaire) for the free electron laser CLIO 1 (Collaboration pour un laser a electrons libres dans l'infrarouge a Orsay) now under construction: this gun involves a grid-cathode assembly manufactured by EIMAC, currently used in the SLAC gun family. For the FEL requirements, the gun must be able to yield a train of short pulses at accuracy frequency or a continuous pulse. Driving together the cathode and the grid the gun produces a continous beam of 12 μs or a pulsed beam of very short pulse of 1 ns at 250 MHz, 125 MHz, 62.5 MHz or 31.25 MHz. The performances of the gun has been tested on a testing bench. A peak current of 1 Amp. for 1 ns width at any frequencies was achieved at an injection voltage of 90 kV

  9. Are "goods for guns" good for the community? An update of a community gun buyback program.

    Science.gov (United States)

    Green, Jonathan; Damle, Rachelle N; Kasper, Rebecca E; Violano, Pina; Manno, Mariann; Nazarey, Pradeep P; Aidlen, Jeremy T; Hirsh, Michael P

    2017-08-01

    Gun violence remains a leading cause of death in the United States. Community gun buyback programs provide an opportunity to dispose of extraneous firearms. The purpose of this study was to understand the demographics, motivation, child access to firearms, and household mental illness of buyback participants in hopes of improving the program's effectiveness. A 2015 Injury Free Coalition for Kids gun buyback program which collaborated with local police departments was studied. We administered a 23-item questionnaire survey to gun buyback participants assessing demographic characteristics, motivation for relinquishing firearms, child firearm accessibility, and mental illness/domestic violence history. A total of 186 individuals from Central/Western Massachusetts turned in 339 weapons. Participants received between US $25 and US $75 in gift cards dependent on what type of gun was turned in, with an average cost of $41/gun. A total of 109 (59%) participants completed the survey. Respondents were mostly white (99%), men (90%) and first-time participants in the program (85.2%). Among survey respondents, 54% turned in firearms "for safety reasons." Respondents reported no longer needing/wanting their weapons (47%) and approximately one in eight participants were concerned the firearm(s) were accessible to children. Most respondents (87%) felt the program encouraged neighborhood awareness of firearm safety. Three of every five participants reported that guns still remained in their homes; additionally, 21% where children could potentially access them and 14% with a history of mental illness/suicide/domestic violence in the home. Gun buybacks can provide a low-cost means of removing unwanted firearms from the community. Most participants felt their homes were safer after turning in the firearm(s). In homes still possessing guns, emphasis on secure gun storage should continue, increasing the safety of children and families. The results of this survey also provided new

  10. Essays in Executive Compensation

    NARCIS (Netherlands)

    D. Zhang (Dan)

    2012-01-01

    textabstractThis dissertation focuses on how executive compensation is designed and its implications for corporate finance and government regulations. Chapter 2 analyzes several proposals to restrict CEO compensation and calibrates two models of executive compensation that describe how firms would

  11. Toward a noncytotoxic glioblastoma therapy: blocking MCP-1 with the MTZ Regimen

    Directory of Open Access Journals (Sweden)

    Salacz ME

    2016-04-01

    Full Text Available Michael E Salacz,1,2 Richard E Kast,3 Najmaldin Saki,4 Ansgar Brüning,5 Georg Karpel-Massler,6 Marc-Eric Halatsch6 1Department of Internal Medicine, 2Department of Neurosurgery, University of Kansas, Kansas City, KS, USA; 3IIAIGC Study Center, Burlington, VT, USA; 4Health Research Institute, Research Center of Thalassemia and Hemoglobinopathy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 5Molecular Biology Laboratory, University Hospital Munich, Munich, Germany; 6Department of Neurosurgery, University of Ulm, Ulm, Germany Abstract: To improve the prognosis of glioblastoma, we developed an adjuvant treatment directed to a neglected aspect of glioblastoma growth, the contribution of nonmalignant monocyte lineage cells (MLCs (monocyte, macrophage, microglia, dendritic cells that infiltrated a main tumor mass. These nonmalignant cells contribute to glioblastoma growth and tumor homeostasis. MLCs comprise of approximately 10%–30% of glioblastoma by volume. After integration into the tumor mass, these become polarized toward an M2 immunosuppressive, pro-angiogenic phenotype that promotes continued tumor growth. Glioblastoma cells initiate and promote this process by synthesizing 13 kDa MCP-1 that attracts circulating monocytes to the tumor. Infiltrating monocytes, after polarizing toward an M2 phenotype, synthesize more MCP-1, forming an amplification loop. Three noncytotoxic drugs, an antibiotic – minocycline, an antihypertensive drug – telmisartan, and a bisphosphonate – zoledronic acid, have ancillary attributes of MCP-1 synthesis inhibition and could be re-purposed, singly or in combination, to inhibit or reverse MLC-mediated immunosuppression, angiogenesis, and other growth-enhancing aspects. Minocycline, telmisartan, and zoledronic acid – the MTZ Regimen – have low-toxicity profiles and could be added to standard radiotherapy and temozolomide. Re-purposing older drugs has advantages of established safety and low

  12. Improved DC Gun Insulator Assembly

    International Nuclear Information System (INIS)

    Neubauer, M.L.; Dudas, A.; Sah, R.; Poelker, M.; Surles-Law, K.E.L.

    2010-01-01

    Many user facilities such as synchrotron radiation light sources and free electron lasers require accelerating structures that support electric fields of 10-100 MV/m, especially at the start of the accelerator chain where ceramic insulators are used for very high gradient DC guns. These insulators are difficult to manufacture, require long commissioning times, and often exhibit poor reliability. Two technical approaches to solving this problem will be investigated. Firstly, inverted ceramics offer solutions for reduced gradients between the electrodes and ground. An inverted design will be presented for 350 kV, with maximum gradients in the range of 5-10 MV/m. Secondly, novel ceramic manufacturing processes will be studied, in order to protect triple junction locations from emission, by applying a coating with a bulk resistivity. The processes for creating this coating will be optimized to provide protection as well as be used to coat a ceramic with an appropriate gradient in bulk resistivity from the vacuum side to the air side of an HV standoff ceramic cylinder. Example insulator designs are being computer modelled, and insulator samples are being manufactured and tested

  13. Gun Carrying by High School Students in Boston, MA: Does Overestimation of Peer Gun Carrying Matter?

    Science.gov (United States)

    Hemenway, David; Vriniotis, Mary; Johnson, Renee M.; Miller, Matthew; Azrael, Deborah

    2011-01-01

    This paper investigates: (1) whether high school students overestimate gun carrying by their peers, and (2) whether those students who overestimate peer gun carrying are more likely to carry firearms. Data come from a randomly sampled survey conducted in 2008 of over 1700 high school students in Boston, MA. Over 5% of students reported carrying a…

  14. Relationship between licensing, registration, and other gun sales laws and the source state of crime guns.

    Science.gov (United States)

    Webster, D W; Vernick, J S; Hepburn, L M

    2001-09-01

    To determine the association between licensing and registration of firearm sales and an indicator of gun availability to criminals. Tracing data on all crime guns recovered in 25 cities in the United States were used to estimate the relationship between state gun law categories and the proportion of crime guns first sold by in-state gun dealers. In cities located in states with both mandatory registration and licensing systems (five cities), a mean of 33.7% of crime guns were first sold by in-state gun dealers, compared with 72.7% in cities that had either registration or licensing but not both (seven cities), and 84.2% in cities without registration or licensing (13 cites). Little of the difference between cities with both licensing and registration and cities with neither licensing nor registration was explained by potential confounders. The share of the population near a city that resides in a neighboring state without licensing or registration laws was negatively associated with the outcome. States with registration and licensing systems appear to do a better job than other states of keeping guns initially sold within the state from being recovered in crimes. Proximity to states without these laws, however, may limit their impact.

  15. Separating Batterers and Guns: A Review and Analysis of Gun Removal Laws in 50 States

    Science.gov (United States)

    Frattaroli, Shannon; Vernick, Jon S.

    2006-01-01

    Firearms play an important role in lethal domestic violence incidents. The authors review state laws regarding two policies to separate batterers from firearms: laws authorizing police to remove firearms when responding to a domestic violence complaint ("police gun removal laws") and laws authorizing courts to order guns removed from batterers…

  16. Influência do 1-MCP na conservação pós-colheita de rosas cv. Vega Influence of 1-MCP on postharvest conservation of roses cv. Vega

    Directory of Open Access Journals (Sweden)

    Júlia De Pietro

    2010-10-01

    Full Text Available Objetivou-se, neste trabalho, estudar aspectos da fisiologia pós-colheita de rosas cortadas cv. Vega, tratadas com diferentes concentrações de 1-metilcicloropropeno (1-MCP. O experimento foi conduzido em delineamento inteiramente casualizado, em esquema fatorial composto por dois fatores: quatro tratamentos pós-colheita e quatro datas de avaliação (0; 4; 8; 12 dias. As flores foram submetidas aos seguintes tratamentos: 1 Água destilada (controle; 2 1-MCP (100 ppb; 3 1-MCP (250 ppb; 4 1-MCP (500 ppb. Foram realizadas as seguintes avaliações: massa fresca, cor, turgescência, curvatura, taxa respiratória, conteúdo relativo de água, conteúdo de carboidratos solúveis, de redutores e de antocianina. Ao contrário do tratamento controle, todas as concentrações de 1-MCP foram eficientes para retardar a senescência das flores, porém, a concentração de 1-MCP a 500 ppb destacou-se pela melhor manutenção da qualidade, além de prolongar a vida decorativa das hastes até 19 dias.The objective of this work was to study aspects of postharvest physiology of cut roses cv. Vega, treated with different concentrations of 1-metilcloropropene (1-MCP. The experiment was conducted in a complete randomized design composed of two factors: four postharvest treatments and four dates of evaluation (0; 4; 8; 12 days. The following treatments were used: 1 distilled water; 2 1-metilciclopropeno (1-MCP 100 ppb; 3 1-MCP 250 ppb; 4 1-MCP 500 ppb. The following evaluations were made: fresh weight, color, turgor, curvature, respiration rate, relative water content, content of soluble carbohydrates, reducing and anthocyanin. Unlike treatment with distilled water, all concentrations of 1-MCP were effective in delaying the senescence of flowers; however, the concentration of 1-MCP at 500 ppb was highlighted by better maintenance of quality and extended decorate life stem up to 19 days.

  17. A high-brightness thermionic microwave electron gun

    Energy Technology Data Exchange (ETDEWEB)

    Borland, Michael [Stanford Univ., CA (United States)

    1991-02-01

    In a collaborative effort by SSRL, AET Associates, and Varian Associates, a high-brightness microwave electron gun using a thermionic cathode has been designed, built, tested, and installed for use with the SSRL 150 MeV linear accelerator. This thesis discusses the physics behind the design and operation of the gun and associated systems, presenting predictions and experimental tests of the gun`s performance. The microwave gun concept is of increasing interest due to its promise of providing higher-current, lower-emittance electron beams than possible from conventional, DC gun technology. In a DC guns, accelerating gradients are less than 8 MV/m, while those in a microwave gun can exceed 100 MV/m, providing much more rapid initial acceleration, thereby reducing the deleterious effects of space-charge. Microwave guns produce higher momentum beams than DC guns, thus lessening space-charge effects during subsequent beam transport. Typical DC guns produce kinetic energies of 80--400 KeV, compared to 2--3 MeV for the SSRL microwave gun. ``State-of-the-art`` microwave gun designs employ laser-driven photocathodes, providing excellent performance but with greater complexity and monetary costs. A thermionic microwave gun with a magnetic bunching system is comparable in cost and complexity to a conventional system, but provides performance that is orders of magnitude better. Simulations of the SSRL microwave gun predict a normalized RMS emittance at the gun exist of < 10 π • mec • μm for a beam consisting of approximately 50% of the particles emitted from the gun, and having a momentum spread ±10%. These emittances are for up to 5 x 109e- per bunch. Chromatic aberrations in the transport line between the gun and linear accelerator increase this to typically < 30 π • me • μm.

  18. The role of MCP-1-CCR2 ligand-receptor axis in chondrocyte degradation and disease progress in knee osteoarthritis

    Directory of Open Access Journals (Sweden)

    Yuan-kun Xu

    Full Text Available BACKGROUND: Osteoarthritis (OA is a common arthritic disease and multifactorial whole-joint disease. Interactions of chemokines and OA is inadequately documented RESULTS: In vivo and in vitro studies were conducted to investigate monocyte chemoattractant protein 1 (MCP-1 and receptor chemokine (C-C motif receptor 2 (CCR2 in chondrocyte degradation and cartilage degeneration. Chondrocytes from 16 OA patients and 6 normal controls were involved in this study. After stimulation of MCP-1, the expression of MCP-1 and CCR2 increased significantly (P < 0.001 and the expression of MMP-13 also increased (P < 0.05. MCP-1 stimulation also induced (or enhanced the apoptosis of OA chondrocytes (P < 0.05. Additionally, the degradation of cartilage matrix markers (metalloproteinase 3 and 13, MMP3 and MMP13 in the culture medium of normal chondrocytes was also assessed. Furthermore, intra-articular injection of MCP-1 in mouse knees induced cartilage degradation and the CCR2 antagonist did not impede cartilage destroy in rats knees of monosodium iodoacetate (MIA model CONCLUSIONS: The results of this study demonstrate that the MCP-1-CCR2 ligand-receptor axis plays a special role in the initiation and progression of OA pathology. Patients with ambiguous etiology can gain some insight from the MCP-1-CCR2 ligand-receptor axis

  19. Study of beam transverse properties of a thermionic electron gun for application to a compact THz free electron laser

    International Nuclear Information System (INIS)

    Hu, Tongning; Qin, Bin; Tan, Ping; Chen, Qushan; Yang, Lei; Pei, Yuanji; Li, Ji

    2014-01-01

    A novel thermionic electron gun adopted for use in a high power THz free electron laser (FEL) is proposed in this paper. By optimization of the structural and radiofrequency (RF) parameters, the physical design of the gun is performed using dynamic calculations. Velocity bunching is used to minimize the bunch's energy spread, and the dynamic calculation results indicate that high quality beams can be provided. The transverse properties of the beams generated by the gun are also analyzed. The novel RF focusing effects of the resonance cavity are investigated precisely and are used to establish emittance compensation, which enables the injector length to be reduced. In addition, the causes of the extrema of the beam radius and the normalized transverse emittance are analyzed and interpreted, respectively, and slice simulations are performed to illustrate how the RF focusing varies along the bunch length and to determine the effects of that variation on the emittance compensation. Finally, by observation of the variations of the beam properties in the drift tube behind the electron gun, prospective assembly scenarios for the complete THz-FEL injector are discussed, and a joint-debugging process for the injector is implemented

  20. Gun ownership and firearm-related deaths.

    Science.gov (United States)

    Bangalore, Sripal; Messerli, Franz H

    2013-10-01

    A variety of claims about possible associations between gun ownership rates, mental illness burden, and the risk of firearm-related deaths have been put forward. However, systematic data on this issue among various countries remain scant. Our objective was to assess whether the popular notion "guns make a nation safer" has any merits. Data on gun ownership were obtained from the Small Arms Survey, and for firearm-related deaths from a European detailed mortality database (World Health Organization), the National Center for Health Statistics, and others. Crime rate was used as an indicator of safety of the nation and was obtained from the United Nations Surveys of Crime Trends. Age-standardized disability-adjusted life-year rates due to major depressive disorder per 100,000 inhabitants with data obtained from the World Health Organization database were used as a putative indicator for mental illness burden in a given country. Among the 27 developed countries, there was a significant positive correlation between guns per capita per country and the rate of firearm-related deaths (r = 0.80; P ownership and mental illness as independent covariates, gun ownership was a significant predictor (P <.0001) of firearm-related deaths, whereas mental illness was of borderline significance (P = .05) only. The number of guns per capita per country was a strong and independent predictor of firearm-related death in a given country, whereas the predictive power of the mental illness burden was of borderline significance in a multivariable model. Regardless of exact cause and effect, however, the current study debunks the widely quoted hypothesis that guns make a nation safer. Copyright © 2013 Elsevier Inc. All rights reserved.

  1. Modeling internal ballistics of gas combustion guns.

    Science.gov (United States)

    Schorge, Volker; Grossjohann, Rico; Schönekess, Holger C; Herbst, Jörg; Bockholdt, Britta; Ekkernkamp, Axel; Frank, Matthias

    2016-05-01

    Potato guns are popular homemade guns which work on the principle of gas combustion. They are usually constructed for recreational rather than criminal purposes. Yet some serious injuries and fatalities due to these guns are reported. As information on the internal ballistics of homemade gas combustion-powered guns is scarce, it is the aim of this work to provide an experimental model of the internal ballistics of these devices and to investigate their basic physical parameters. A gas combustion gun was constructed with a steel tube as the main component. Gas/air mixtures of acetylene, hydrogen, and ethylene were used as propellants for discharging a 46-mm caliber test projectile. Gas pressure in the combustion chamber was captured with a piezoelectric pressure sensor. Projectile velocity was measured with a ballistic speed measurement system. The maximum gas pressure, the maximum rate of pressure rise, the time parameters of the pressure curve, and the velocity and path of the projectile through the barrel as a function of time were determined according to the pressure-time curve. The maximum gas pressure was measured to be between 1.4 bar (ethylene) and 4.5 bar (acetylene). The highest maximum rate of pressure rise was determined for hydrogen at (dp/dt)max = 607 bar/s. The muzzle energy was calculated to be between 67 J (ethylene) and 204 J (acetylene). To conclude, this work provides basic information on the internal ballistics of homemade gas combustion guns. The risk of injury to the operator or bystanders is high, because accidental explosions of the gun due to the high-pressure rise during combustion of the gas/air mixture may occur.

  2. Localization of monocyte chemotactic and activating factor (MCAF/MCP-1) in psoriasis

    DEFF Research Database (Denmark)

    Deleuran, M; Buhl, L; Ellingsen, T

    1996-01-01

    in the epidermal pustules in pustular psoriasis. In normals positive staining was observed in all the layers of the epidermis and in a few perivascular cells and blood vessels in the dermis. Where present in normal and diseased skin, eccrine ducts of sweat glands and sebaceous glands stained positive for MCAF......The monocyte chemotactic protein-1 (MCAF) also termed MCP-1, a strong chemotactic factor towards monocytes, is produced by several cell types present in the skin. The in situ presence of MCAF/MCP-1 protein in the skin has, however, not yet been established. Using immunohistochemical techniques we...... have investigated the distribution of MCAF in skin from patients with different types of psoriasis and normal healthy volunteers. We report the novel finding that psoriasis has strong positive immunostaining for MCAF located to all the layers of the epidermis, except the stratum granulosum, in pustular...

  3. Conservação da qualidade de caqui 'Fuyu' em ambiente refrigerado pela combinação de 1-MCP e atmosfera modificada Quality maintenance of 'Fuyu' persimmon in cold storage by combining 1-MCP and modified atmosphere

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Argenta

    2009-06-01

    Full Text Available O presente estudo analisou os efeitos do inibidor da ação do etileno 1-MCP (1-metilciclopropeno, da AM (atmosfera modificada e do oxidante de etileno KMnO4 (permanganato de potássio sobre a qualidade de caqui 'Fuyu' após a armazenagem refrigerada. Os fatores 1-MCP, AM e KMnO4 foram combinados de quatro maneiras, correspondendo aos seguintes tratamentos: T1 Controle + AM + KMnO4;T2 1-MCP + AM + KMnO4; T3 1-MCP + AM, e T4 1-MCP + AA (AA=atmosfera do ar. Frutos maduro-firmes com coloração da casca predominantemente amarela foram colhidos em sete pomares comerciais no nordeste do Estado do Rio Grande do Sul. Parte dos frutos foi exposta a 0.3 µL L-1 de 1-MCP por 12 h em 24 h após a colheita. A seguir, os frutos foram armazenados sob AA ou sob AM induzida por bolsas de polietileno (0,04 mm de espessura, por 20; 40; 60 ou 80 dias a -0,1±0,8ºC. Dois sachês contendo 8,5 g de Alumina-KMnO4foram adicionados em cada uma das bolsas de polietileno dos tratamentos um e dois, antes de elas serem vedadas. Os frutos de cada período de armazenagem refrigerada foram analisados após 0; 3; 6 ou 9 dias de prateleira sob AA a 22±1ºC. O tratamento 1-MCP retardou o amolecimento da polpa, mas não afetou consistentemente o desenvolvimento de 'estrias' e manchas pretas na superfície dos frutos armazenados sob AM contendo KMnO4. A incidência de 'estrias' e manchas pretas em frutos tratados com 1-MCP e armazenados sob AM foi significativamente menor que a de frutos tratados com 1-MCP e armazenados sob AA. Houve efeitos aditivos do 1-MCP e AM na conservação da firmeza e na redução de danos por frio manifestados pela formação de textura gel-firme e manchas translúcidas na casca. O uso de KMnO4 não aumentou a conservação da qualidade dos frutos quando tratados com 1-MCP e armazenados sob AM. O desenvolvimento dos distúrbios da epiderme dependeu do pomar e de períodos de armazenagem e prateleira. No entanto, os benefícios da combinação de 1-MCP e

  4. Design study of a low-emittance high-repetition rate thermionic rf gun

    Directory of Open Access Journals (Sweden)

    A. Opanasenko

    2017-05-01

    Full Text Available We propose a novel gridless continuous-wave radiofrequency (rf thermionic gun capable of generating nC ns electron bunches with a rms normalized slice emittance close to the thermal level of 0.3 mm mrad. In order to gate the electron emission, an externally heated thermionic cathode is installed into a stripline-loop conductor. Two high-voltage pulses propagating towards each other in the stripline-loop overlap in the cathode region and create a quasielectrostatic field gating the electron emission. The repetition rate of pulses is variable and can reach up to one MHz with modern solid-state pulsers. The stripline attached to a rf gun cavity wall has with the wall a common aperture that allows the electrons to be injected into the rf cavity for further acceleration. Thanks to this innovative gridless design, simulations suggest that the bunch emittance is approximately at the thermal level after the bunch injection into the cavity provided that the geometry of the cathode and aperture are properly designed. Specifically, a concave cathode is adopted to imprint an Ƨ-shaped distribution onto the beam transverse phase-space to compensate for an S-shaped beam distribution created by the spherical aberration of the aperture-cavity region. In order to compensate for the energy spread caused by rf fields of the rf gun cavity, a 3rd harmonic cavity is used. A detailed study of the electrodynamics of the stripline and rf gun cavity as well as the beam optics and bunch dynamics are presented.

  5. Role of human pulmonary fibroblast-derived MCP-1 in cell activation and migration in experimental silicosis

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Xueting [Department of Physiology, Medical School of Southeast University, Nanjing, Jiangsu 210009 (China); Fang, Shencun [Nine Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, Jiangsu 210029 (China); Liu, Haijun [Neurobiology Laboratory, New Drug Screening Centre, China Pharmaceutical University, Nanjing, Jiangsu 210009 (China); Wang, Xingang; Dai, Xiaoniu; Yin, Qing; Yun, Tianwei [Department of Physiology, Medical School of Southeast University, Nanjing, Jiangsu 210009 (China); Wang, Wei; Zhang, Yingming [Nine Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, Jiangsu 210029 (China); Liao, Hong [Neurobiology Laboratory, New Drug Screening Centre, China Pharmaceutical University, Nanjing, Jiangsu 210009 (China); Zhang, Wei [Department of Physiology, Medical School of Southeast University, Nanjing, Jiangsu 210009 (China); Yao, Honghong [Department of Pharmacology, Medical School of Southeast University, Nanjing, Jiangsu 210009 (China); Chao, Jie, E-mail: chaojie@seu.edu.cn [Department of Physiology, Medical School of Southeast University, Nanjing, Jiangsu 210009 (China)

    2015-10-15

    Background: Silicosis is a systemic disease caused by inhaling silicon dioxide (SiO{sub 2}). Phagocytosis of SiO{sub 2} in the lung initiates an inflammatory cascade that results in fibroblast proliferation and migration and subsequent fibrosis. Clinical evidence indicates that the activation of alveolar macrophages by SiO{sub 2} produces rapid and sustained inflammation that is characterized by the generation of monocyte chemotactic protein 1 (MCP-1), which induces fibrosis. Pulmonary fibroblast-derived MCP-1 may play a critical role in fibroblast proliferation and migration. Methods and results: Experiments using primary cultured adult human pulmonary fibroblasts (HPF-a) demonstrated the following results: 1) SiO{sub 2} treatment resulted in the rapid and sustained induction of MCP-1 as well as the elevation of the CC chemokine receptor type 2 (CCR2) protein levels; 2) pretreatment of HPF-a with RS-102895, a specific CCR2 inhibitor, abolished the SiO{sub 2}-induced increase in cell activation and migration in both 2D and 3D culture systems; and 3) RNA interference targeting CCR2 prevented the SiO{sub 2}-induced increase in cell migration. Conclusion: These data demonstrated that the up-regulation of pulmonary fibroblast-derived MCP-1 is involved in pulmonary fibroblast migration induced by SiO{sub 2}. CCR2 was also up-regulated in response to SiO{sub 2}, and this up-regulation facilitated the effect of MCP-1 on fibroblasts. Our study deciphered the link between fibroblast-derived MCP-1 and SiO{sub 2}-induced cell migration. This finding provides novel insight into the potential of MCP-1 in the development of novel therapeutic strategies for silicosis. - Highlights: • Role of pulmonary fibroblast-derived MCP-1 in experimental silicosis was studied. • SiO{sub 2} induced MCP-1 release from cultured human pulmonary fibroblast (HPF-a). • SiO{sub 2} directly activated HPF-a via the MCP-1/CCR2 pathway. • SiO{sub 2} increased HPF-a migration in both 2D and 3D

  6. Role of human pulmonary fibroblast-derived MCP-1 in cell activation and migration in experimental silicosis

    International Nuclear Information System (INIS)

    Liu, Xueting; Fang, Shencun; Liu, Haijun; Wang, Xingang; Dai, Xiaoniu; Yin, Qing; Yun, Tianwei; Wang, Wei; Zhang, Yingming; Liao, Hong; Zhang, Wei; Yao, Honghong; Chao, Jie

    2015-01-01

    Background: Silicosis is a systemic disease caused by inhaling silicon dioxide (SiO 2 ). Phagocytosis of SiO 2 in the lung initiates an inflammatory cascade that results in fibroblast proliferation and migration and subsequent fibrosis. Clinical evidence indicates that the activation of alveolar macrophages by SiO 2 produces rapid and sustained inflammation that is characterized by the generation of monocyte chemotactic protein 1 (MCP-1), which induces fibrosis. Pulmonary fibroblast-derived MCP-1 may play a critical role in fibroblast proliferation and migration. Methods and results: Experiments using primary cultured adult human pulmonary fibroblasts (HPF-a) demonstrated the following results: 1) SiO 2 treatment resulted in the rapid and sustained induction of MCP-1 as well as the elevation of the CC chemokine receptor type 2 (CCR2) protein levels; 2) pretreatment of HPF-a with RS-102895, a specific CCR2 inhibitor, abolished the SiO 2 -induced increase in cell activation and migration in both 2D and 3D culture systems; and 3) RNA interference targeting CCR2 prevented the SiO 2 -induced increase in cell migration. Conclusion: These data demonstrated that the up-regulation of pulmonary fibroblast-derived MCP-1 is involved in pulmonary fibroblast migration induced by SiO 2 . CCR2 was also up-regulated in response to SiO 2 , and this up-regulation facilitated the effect of MCP-1 on fibroblasts. Our study deciphered the link between fibroblast-derived MCP-1 and SiO 2 -induced cell migration. This finding provides novel insight into the potential of MCP-1 in the development of novel therapeutic strategies for silicosis. - Highlights: • Role of pulmonary fibroblast-derived MCP-1 in experimental silicosis was studied. • SiO 2 induced MCP-1 release from cultured human pulmonary fibroblast (HPF-a). • SiO 2 directly activated HPF-a via the MCP-1/CCR2 pathway. • SiO 2 increased HPF-a migration in both 2D and 3D model via the MCP-1/CCR2 pathway. • RNA-i of MCP-1/CCR2

  7. Role of MCP-1 in pleural effusion development in a carrageenan-induced murine model of pleurisy.

    Science.gov (United States)

    Lansley, Sally M; Cheah, Hui Min; Lee, Y C Gary

    2017-05-01

    Exudative pleural effusions affect over 1500 patients per million population each year. The pathobiology of pleural exudate formation remains unclear. Our recent study revealed monocyte chemotactic protein-1 (MCP-1) as a key driver of fibrinolytic-induced exudate effusion while another study found a role for MCP-1 in malignant effusion formation. In the present study, we further evaluated the role of MCP-1 in the development of pleural effusion in a mouse model of acute pleural inflammation. λ-Carrageenan (CAR) was injected into the pleural cavity of CD1 mice and pleural effusion volume measured up to 16 h post-injection. Pleural effusion and serum protein and MCP-1 concentrations were measured and differential cell counts performed in fluids. Mice were also treated with either intraperitoneal (i) anti-MCP-1 antibody or isotype control or (ii) an MCP-1 receptor (CCR2) antagonist or vehicle control 12 h prior to and at the time of CAR injection. Intrapleural CAR induced significant pleural fluid accumulation (300.0 ± 49.9 μL) in mice after 4 h. Pleural fluid MCP-1 concentrations were significantly higher than corresponding serum MCP-1 (144 603 ± 23 204 pg/mL vs 3703 ± 801 pg/mL, P pleural fluid formation was seen both with anti-MCP-1 antibody (median (interquartile range, IQR): 36 (0-168) μL vs controls 290 (70-436) μL; P = 0.02) or CCR2 antagonist (153 (30-222) μL vs controls 240 (151-331) μL, P = 0.0049). Blockade of MCP-1 activity significantly reduced inflammatory pleural effusion formation in a CAR model. Together with recent successes in MCP-1 blockade in other effusion formation models, our data strongly support clinical evaluation of MCP-1 antagonists as a novel approach to pleural fluid management. © 2016 Asian Pacific Society of Respirology.

  8. EFECTO DEL 1-METIL-CICLOPROPENO (1-MCP EN LA MADURACIÓN DE BANANO

    Directory of Open Access Journals (Sweden)

    Kattia Chang-Yuen

    2005-01-01

    Full Text Available Se evaluó la eficacia del 1-metil-ciclopropeno (1-MCP en la maduración del banano (Musa sp Cavendish, aplicado después del empaque en fruta para el mercado de EE.UU. y Europa. Se utilizó fruta de 3 diferentes compañías bananeras; la fruta fue expuesta a 0, 20 y 30 nl l-1 de 1-MCP, por 24 h. Posteriormente, fue sometida a simulación de transporte, según el mercado de destino (7 días EE.UU. y 15 días Europa. Finalizada la simulación se indujo el proceso de maduración con etileno. Las evaluaciones se realizaron cada 2 días, e incluyeron análisis de calidad externa (enfermedades poscosecha y desarrollo de color externo de la cáscara y de calidad interna (oBrix, firmeza, porcentaje de acidez titulable y tasa de produc ción de CO2. Una aplicación de 30 nl l-1 de 1-MCP, generó una ganancia de más de 4 días de vida de anaquel por encima de la fruta control.La apariencia externa y la calidad interna de la fruta no se vio afectada de forma negativa por la exposición al 1-MCP, aunque se recomienda realizar pruebas sensoriales con consumidores en los mercados de destino.

  9. State of art report for high temperature wear test of SMART MCP and CEDM bearing material

    International Nuclear Information System (INIS)

    Cho, Yong Hu; Lee, Jae Seon; Park, Jin Seok; Kim, Ji Ho; Kim, Jong In

    2000-03-01

    Wear resistance properties of machine elements has been more critical in view of its significant effect on life extension, economics and material saving because it has been recognized that nearly 80 percent of damages of mechanical elements in the friction pairs are due to the material loss by wear. And wear properties have direct influence on the life of a machine in a great extend under extremely severe operating condition. Therefore highly improved wear properties of machine elements operating in such circumstances is heavily required. The purpose of this report is to survey current technology for high temperature wear test in order to establish the test plan for the life evaluation of SMART MCP and CEDM bearing materials. Friction and wear test will be done under high pressure (170 MPa) and high temperature (350 degree C) with water as lubricant to simulate the operating condition of the nuclear power reactor. Because pump type for MCP is selected as the caned motor pump which needs no mechanical sealing, the rotating shaft on which bearing is fully submerged by main coolant with high temperature. So MCP bearing operates without additional lubricant. CEDM is adopted as the ball-screw type with fine controllability. So the driving part is designed as the immersed-in type by main coolant. Therefore the anti-wear and reliability of driving parts are much consequent to guarantee the lifetime and the safety of the whole system. Tribometer adapted to high temperature and pressure circumstance is needed to execute bearing material testing. Test parameters are material, sliding speed, sliding distance and applied load. In order to identify the wear mechanism, optical microscope and surface roughness testers are required. The result of this report will provide an elementary data to develop bearing materials and to estimate bearing lifetime for the bearings of MCP and CEDM in SMART. (author)

  10. Development and tests of MCP based timing and multiplicity detector for MIPs

    Science.gov (United States)

    Feofilov, G.; Kondratev, V.; Stolyarov, O.; Tulina, T.; Valiev, F.; Vinogradov, L.

    2017-01-01

    We present summary of technological developments and tests of the MCP based large area detector aimed at precise timing and charged particles multiplicity measurements. Results obtained in course of these developments of isochronous (simultaneity) precise signal readout, passive summation of 1 ns signals, fast (1 GHz) front-end electronics, miniature vacuum systems, etc. could be potentially interesting for a number of future applications in different fields.

  11. Ethylene and 1-MCP regulate major volatile biosynthetic pathways in apple fruit.

    Science.gov (United States)

    Yang, Xiaotang; Song, Jun; Du, Lina; Forney, Charles; Campbell-Palmer, Leslie; Fillmore, Sherry; Wismer, Paul; Zhang, Zhaoqi

    2016-03-01

    The effects of ethylene and 1-methylcyclopropene (1-MCP) on apple fruit volatile biosynthesis and gene expression were investigated. Statistical analysis identified 17 genes that changed significantly in response to ethylene and 1-MCP treatments. Genes encoding branched-chain amino acid aminotransferase (BCAT), aromatic amino acid aminotransferase (ArAT) and amino acid decarboxylases (AADC) were up-regulated during ripening and further enhanced by ethylene treatment. Genes related to fatty acid synthesis and metabolism, including acyl-carrier-proteins (ACPs), malonyl-CoA:ACP transacylase (MCAT), acyl-ACP-desaturase (ACPD), lipoxygenase (LOX), hydroperoxide lyase (HPL), alcohol dehydrogenase (ADH), pyruvate decarboxylase (PDC2), β-oxidation, acyl-CoA synthetase (ACS), enoyl-CoA hydratase (ECHD), acyl-CoA dehydrogenase (ACAD), and alcohol acyltransferases (AATs) also increased during ripening and in response to ethylene treatment. Allene oxide synthase (AOS), alcohol dehydrogenase 1 (ADH1), 3-ketoacyl-CoA thiolase and branched-chain amino acid aminotransferase 2 (BCAT2) decreased in ethylene-treated fruit. Treatment with 1-MCP and ethylene generally produced opposite effects on related genes, which provides evidence that regulation of these genes is ethylene dependent. Crown Copyright © 2015. Published by Elsevier Ltd. All rights reserved.

  12. Transmission-Line Readout with Good Time and Space Resolutions for Planacon MCP-PMTs

    CERN Document Server

    Tang, F; Byrum, K; Drake, G; Ertley, C; Frisch, H; Genat, J-F; May, E

    2008-01-01

    With commercially-available multi-anode microchannel plate photomultiplier tubes (MCP-PMT) and electronics, resolutions significantly better than 10 psec have been achieved in small systems with a few readout channels[1,2]. For large-scale time-of-flight systems used in particle physics, which may cover tens of square meters, a solution must be found with a manageable number of electronics channels and low total power consumption on the readout electronics without degrading the system timing resolution. We present here the design of a transmission-line readout for a Photonis Planacon MCP-PMT that has these characteristics. The tube, which is 5 cm square, is characterized by signal pulse rise times in the order of 200 psec and transit time spreads (TTS) in the order of 25 psec[1, 2]. The model 85011-011 MCP has 1024 anode pads laid out in an array of 32 by 32 on the back of the tube. The proposed readout is implemented on a Rogers 4350B printed circuit board with 32 parallel 50-ohm transmission lines on 1.6 mm...

  13. Development of a dual MCP framing camera for high energy x-rays

    Energy Technology Data Exchange (ETDEWEB)

    Izumi, N., E-mail: izumi2@llnl.gov; Hall, G. N.; Carpenter, A. C.; Allen, F. V.; Cruz, J. G.; Felker, B.; Hargrove, D.; Holder, J.; Lumbard, A.; Montesanti, R.; Palmer, N. E.; Piston, K.; Stone, G.; Thao, M.; Vern, R.; Zacharias, R.; Landen, O. L.; Tommasini, R.; Bradley, D. K.; Bell, P. M. [Lawrence Livermore National Laboratory, Livermore, California 94550 (United States); and others

    2014-11-15

    Recently developed diagnostic techniques at LLNL require recording backlit images of extremely dense imploded plasmas using hard x-rays, and demand the detector to be sensitive to photons with energies higher than 50 keV [R. Tommasini et al., Phys. Phys. Plasmas 18, 056309 (2011); G. N. Hall et al., “AXIS: An instrument for imaging Compton radiographs using ARC on the NIF,” Rev. Sci. Instrum. (these proceedings)]. To increase the sensitivity in the high energy region, we propose to use a combination of two MCPs. The first MCP is operated in a low gain regime and works as a thick photocathode, and the second MCP works as a high gain electron multiplier. We tested the concept of this dual MCP configuration and succeeded in obtaining a detective quantum efficiency of 4.5% for 59 keV x-rays, 3 times larger than with a single plate of the thickness typically used in NIF framing cameras.

  14. The cross-validated AUC for MCP-logistic regression with high-dimensional data.

    Science.gov (United States)

    Jiang, Dingfeng; Huang, Jian; Zhang, Ying

    2013-10-01

    We propose a cross-validated area under the receiving operator characteristic (ROC) curve (CV-AUC) criterion for tuning parameter selection for penalized methods in sparse, high-dimensional logistic regression models. We use this criterion in combination with the minimax concave penalty (MCP) method for variable selection. The CV-AUC criterion is specifically designed for optimizing the classification performance for binary outcome data. To implement the proposed approach, we derive an efficient coordinate descent algorithm to compute the MCP-logistic regression solution surface. Simulation studies are conducted to evaluate the finite sample performance of the proposed method and its comparison with the existing methods including the Akaike information criterion (AIC), Bayesian information criterion (BIC) or Extended BIC (EBIC). The model selected based on the CV-AUC criterion tends to have a larger predictive AUC and smaller classification error than those with tuning parameters selected using the AIC, BIC or EBIC. We illustrate the application of the MCP-logistic regression with the CV-AUC criterion on three microarray datasets from the studies that attempt to identify genes related to cancers. Our simulation studies and data examples demonstrate that the CV-AUC is an attractive method for tuning parameter selection for penalized methods in high-dimensional logistic regression models.

  15. Ethylene and 1-MCP affect the postharvest behavior of yellow pitahaya fruits (Selenicereus megalanthus Haw.

    Directory of Open Access Journals (Sweden)

    Yuli Alexandra Deaquiz

    2014-04-01

    Full Text Available The pitahaya or dragon fruit is one of the most representative exotic fruits that Colombia has, with an important, growing international market, but the cultivation and postharvest of this fruit lack sufficient technological support to be more competitive. Therefore, alternatives that provide good-quality products that meet market requirements are very important. Therefore, the objective of this research was to determine the effect of a ripening retardant and ethylene application on the conservation and quality of pitahaya fruits and the possible changes during ripening associated with ethylene, for which a completely randomized design with three treatments was used, corresponding to the application of ethylene (ethephon, 3 mL L-1, 1-methylcyclopropene (1-MCP, 600 mg L-1 and a control, with four replications, for a total of 12 experimental units. The fruits were stored at 18°C with 75% relative humidity. The 1-MCP application significantly decreased the loss of firmness, total soluble solids, loss of fresh mass and respiratory rate. Fruits from the control and ethylene treatment tended toward a climateric respiratory behavior. The total carotenoid content of the fruits was significantly higher in the ethylene application and the control treatment, which was consistent with the color change of the fruits. It can be concluded that the 1-MCP application reduced the ethylene action, slowing the ripening of the dragon fruits.

  16. A high-brightness thermionic microwave electron gun

    International Nuclear Information System (INIS)

    Borland, M.

    1991-02-01

    In a collaborative effort by SSRL, AET Associates, and Varian Associates, a high-brightness microwave electron gun using a thermionic cathode has been designed, built, tested, and installed for use with the SSRL 150 MeV linear accelerator. This thesis discusses the physics behind the design and operation of the gun and associated systems, presenting predictions and experimental tests of the gun's performance. The microwave gun concept is of increasing interest due to its promise of providing higher-current, lower-emittance electron beams than possible from conventional, DC gun technology. In a DC guns, accelerating gradients are less than 8 MV/m, while those in a microwave gun can exceed 100 MV/m, providing much more rapid initial acceleration, thereby reducing the deleterious effects of space-charge. Microwave guns produce higher momentum beams than DC guns, thus lessening space-charge effects during subsequent beam transport. Typical DC guns produce kinetic energies of 80--400 KeV, compared to 2--3 MeV for the SSRL microwave gun. ''State-of-the-art'' microwave gun designs employ laser-driven photocathodes, providing excellent performance but with greater complexity and monetary costs. A thermionic microwave gun with a magnetic bunching system is comparable in cost and complexity to a conventional system, but provides performance that is orders of magnitude better. Simulations of the SSRL microwave gun predict a normalized RMS emittance at the gun exist of e c · μm for a beam consisting of approximately 50% of the particles emitted from the gun, and having a momentum spread ±10%. These emittances are for up to 5 x 10 9 e - per bunch. Chromatic aberrations in the transport line between the gun and linear accelerator increase this to typically e · μm

  17. Development of plasma cathode electron guns

    Science.gov (United States)

    Oks, Efim M.; Schanin, Peter M.

    1999-05-01

    The status of experimental research and ongoing development of plasma cathode electron guns in recent years is reviewed, including some novel upgrades and applications to various technological fields. The attractiveness of this kind of e-gun is due to its capability of creating high current, broad or focused beams, both in pulsed and steady-state modes of operation. An important characteristic of the plasma cathode electron gun is the absence of a thermionic cathode, a feature which leads to long lifetime and reliable operation even in the presence of aggressive background gas media and at fore-vacuum gas pressure ranges such as achieved by mechanical pumps. Depending on the required beam parameters, different kinds of plasma discharge systems can be used in plasma cathode electron guns, such as vacuum arcs, constricted gaseous arcs, hollow cathode glows, and two kinds of discharges in crossed E×B fields: Penning and magnetron. At the present time, plasma cathode electron guns provide beams with transverse dimension from fractional millimeter up to about one meter, beam current from microamperes to kiloamperes, beam current density up to about 100 A/cm2, pulse duration from nanoseconds to dc, and electron energy from several keV to hundreds of keV. Applications include electron beam melting and welding, surface treatment, plasma chemistry, radiation technologies, laser pumping, microwave generation, and more.

  18. ECR ion source with electron gun

    Science.gov (United States)

    Xie, Zu Q.; Lyneis, Claude M.

    1993-01-01

    An Advanced Electron Cyclotron Resonance ion source (10) having an electron gun (52) for introducing electrons into the plasma chamber (18) of the ion source (10). The ion source (10) has a injection enclosure (12) and a plasma chamber tank (14). The plasma chamber (18) is defined by a plurality of longitudinal magnets (16). The electron gun (52) injects electrons axially into the plasma chamber (18) such that ionization within the plasma chamber (18) occurs in the presence of the additional electrons produced by the electron gun (52). The electron gun (52) has a cathode (116) for emitting electrons therefrom which is heated by current supplied from an AC power supply (96) while bias potential is provided by a bias power supply (118). A concentric inner conductor (60) and Outer conductor (62) carry heating current to a carbon chuck (104) and carbon pusher (114) Which hold the cathode (116) in place and also heat the cathode (16). In the Advanced Electron Cyclotron Resonance ion source (10), the electron gun (52) replaces the conventional first stage used in prior art electron cyclotron resonance ion generators.

  19. Tri-Service Green Gun Barrel (PP 1074)

    National Research Council Canada - National Science Library

    Rusch, Lawrence F

    2003-01-01

    ...) PP 1074 Tri-Service Green Gun Barrel. The program's goal was to develop an environmentally friendly process for depositing wear and erosion resistant materials onto gun bores replacing the current hazardous aqueous electro-deposition...

  20. To Your Health: NLM update transcript - Gun safety strategies

    Science.gov (United States)

    ... transcript040918.html To Your Health: NLM update Transcript Gun safety strategies : 04/09/2018 To use the ... on weekly topics. An evidence-based, public health gun safety strategy that is consistent with second amendment ...

  1. Simple gun for vapor deposition of organic thin films

    International Nuclear Information System (INIS)

    Sato, N.; Seki, K.; Inokuchi, H.

    1987-01-01

    A simple evaporation gun for preparing organic thin films was fabricated using commercially available parts of an electron gun for a TV Braun tube. The device permits sample heating to be easily controlled because of the small heat capacity

  2. The electromagnetic rocket gun impact fusion driver

    International Nuclear Information System (INIS)

    Winterberg, F.

    1984-01-01

    A macroparticle accelerator to be used as an impact fusion driver is discussed and which can accelerate a small projectile to --200 km/sec over a distance of a few 100 meters. The driver which we have named electromagnetic rocket gun, accelerates a small rocket-like projectile by a travelling magnetic wave. The rocket propellant not only serves as a sink to absorb the heat produced in the projectile by resistive energy losses, but at the same time is also the source of additional thrust through the heating of the propellant to high temperatures by the travelling magnetic wave. The total thrust on the projectile is the sum of the magnetic and recoil forces. In comparison to a rocket, the efficiency is here much larger, with the momentum transferred to the gun barrel of the gun rather than to a tenuous jet. (author)

  3. Secondary emission electron gun using external primaries

    Science.gov (United States)

    Srinivasan-Rao, Triveni [Shoreham, NY; Ben-Zvi, Ilan [Setauket, NY

    2009-10-13

    An electron gun for generating an electron beam is provided, which includes a secondary emitter. The secondary emitter includes a non-contaminating negative-electron-affinity (NEA) material and emitting surface. The gun includes an accelerating region which accelerates the secondaries from the emitting surface. The secondaries are emitted in response to a primary beam generated external to the accelerating region. The accelerating region may include a superconducting radio frequency (RF) cavity, and the gun may be operated in a continuous wave (CW) mode. The secondary emitter includes hydrogenated diamond. A uniform electrically conductive layer is superposed on the emitter to replenish the extracted current, preventing charging of the emitter. An encapsulated secondary emission enhanced cathode device, useful in a superconducting RF cavity, includes a housing for maintaining vacuum, a cathode, e.g., a photocathode, and the non-contaminating NEA secondary emitter with the uniform electrically conductive layer superposed thereon.

  4. Handgun waiting periods reduce gun deaths.

    Science.gov (United States)

    Luca, Michael; Malhotra, Deepak; Poliquin, Christopher

    2017-11-14

    Handgun waiting periods are laws that impose a delay between the initiation of a purchase and final acquisition of a firearm. We show that waiting periods, which create a "cooling off" period among buyers, significantly reduce the incidence of gun violence. We estimate the impact of waiting periods on gun deaths, exploiting all changes to state-level policies in the Unites States since 1970. We find that waiting periods reduce gun homicides by roughly 17%. We provide further support for the causal impact of waiting periods on homicides by exploiting a natural experiment resulting from a federal law in 1994 that imposed a temporary waiting period on a subset of states. Copyright © 2017 the Author(s). Published by PNAS.

  5. Mechanical design of a RF electron gun

    International Nuclear Information System (INIS)

    Woodle, M.H.; Batchelor, K.; Sheehan, J.

    1989-01-01

    Brookhaven National Laboratory is building an Accelerator Test Facility at which we plan to study laser acceleration of electrons, inverse free electron lasers and the production of X-rays by non-linear Compton scattering. The facility contains an electron gun, linac, lasers and ancillary systems which will enable the production of 6 ps duration pulses of 50-100 MeV electrons. The electron source is an one and one half cell RF Electron gun which utilizes either a thermionic or photoemissive cathode to produce 5 MeV electrons. This paper discusses how gun mechanical design considerations such as material, vacuum maintenance, surface finish, fabrication methods, cavity tuning, and cathode replacement were reconciled to arrive at the final design. 9 refs., 2 figs., 2 tabs

  6. Mechanical design of a rf electron gun

    International Nuclear Information System (INIS)

    Woodle, M.H.; Batchelor, K.; Sheehan, J.

    1988-01-01

    Brookhaven National Laboratory is building an Accelerator Test Facility at which we plan to study laser acceleration of electrons inverse free electron lasers and the production of X-rays by non- linear Compton scattering. The facility contains an electron gun, linac, lasers and ancillary systems which will enable the production of 6 ps duration pulses of 50--100 MeV electrons. The electron source is an one and one half cell RF Electron gun which utilizes either a thermionic or photoemissive cathode to produce 5 MeV electrons. This paper discusses how gun mechanical design considerations such as material, vacuum maintenance, surface finish, fabrication methods, cavity tuning, and cathode replacement were reconciled to arrive at the final design. 9 refs., 2 figs., 2 tabs

  7. Photocathode operation of a thermionic RF gun

    International Nuclear Information System (INIS)

    Thorin, S.; Cutic, N.; Lindau, F.; Werin, S.; Curbis, F.

    2009-01-01

    The thermionic RF gun using a BaO cathode at the MAX-lab linac injector has been successfully commissioned for additional operation as a photocathode gun. By retaining the BaO cathode, lowering the temperature below thermal emission and illuminating it with a UV (263 nm) 9 ps laser pulse a reduced emittance and enhanced emission control has been achieved. Measurements show a normalised emittance of 5.5 mm mrad at 200 pC charge and a maximum quantum efficiency of 1.1x10 -4 . The gun is now routinely switched between storage ring injections in thermionic mode and providing a beam for the MAX-lab test FEL in photocathode mode.

  8. Characterizations of MCP performance in the hard x-ray range (6–25 keV)

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Ming, E-mail: minwu@sandia.gov; Rochau, Greg [Sandia National Laboratory, Albuquerque, New Mexico 87185 (United States); Moy, Ken [Special Technology Laboratories, NSTec, Santa Barbara, California 93111-2335 (United States); Kruschwitz, Craig [National Security Technologies, LLC, Los Alamos Operations, Los Alamos, New Mexico 87544 (United States)

    2014-11-15

    MCP detector performance at hard x-ray energies from 6 to 25 keV was recently investigated using NSLS beamline X15A at BNL. Measurements were made with an NSTec Gen-II (H-CA-65) framing camera, based on a Photonis MCP with ∼10 μm in diameter pores, ∼12 μm center-center spacing, an L/D ratio of 46, and a bias angle of 8°. The MCP characterizations were focused on (1) energy and angle dependent sensitivity, (2) energy and angle dependent spatial resolution, (3) energy dependent gain performance, and (4) energy dependent dynamic range. These measurement corroborated simulation results using a Monte Carlo model that included hard x-ray interactions and the subsequent electron cascade in the MCP.

  9. Long pulse, plasma cathode E-gun

    International Nuclear Information System (INIS)

    Goebel, D.M.; Schumacher, R.W.; Watkins, R.M.

    1993-01-01

    A unique, long-pulse E-gun has been developed for high-power tube applications. The Hollow-Cathode-Plasma (HCP) E-gun overcomes the limitations of conventional thermionic-cathode guns that have limited current density (typically ≤ 10 A/cm 2 ) or field-emission guns that offer high current density but suffer from short pulsewidth capability (typically 50 A/cm 2 ), long-pulse operation without gap closure, and also requires no cathode-heater power. The gun employs a low-pressure glow discharge inside a hollow cathode (HC) structure to provide a stable, uniform plasma surface from which a high current-density electron beam can be extracted. The plasma density is controlled by a low-voltage HC discharge pulser to produce the desired electron current density at the first grid of a multi-grid accelerator system. A dc high-voltage electron-beam supply accelerates the electrons across the gap, while the HC pulser modulates the beam current to generate arbitrary pulse waveforms. The electron accelerator utilizes a multi-aperture array that produces a large area, high perveance (>35 μpervs) beam consisting initially of many individual beamlets. The E-beam is normally operated without an applied magnetic field in the ion-focused regime, where the plasma produced by beam ionization of a background gas space-charge neutralizes the beam, and the Bennett self-pinch compresses the beamlets and increases the current density. The self-pinched beam has been observed to propagate over a meter without beam breakup or instabilities. The HCP E-gun has been operated at voltages up to 150 kV, currents up to 750 A, and pulse lengths of up to 120 μsec

  10. Improved DC Gun and Insulator Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Neubauer, Michael [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

    2015-01-11

    Many user facilities such as synchrotron radiation light sources and free electron lasers rely on DC high voltage photoguns with internal field gradients as high as 10 to 15 MV/m. These high gradients often lead to field emission which poses serious problems for the photocathode used to generate the electron beam and the ceramic insulators used to bias the photocathode at high voltage. Ceramic insulators are difficult to manufacture, require long commissioning times, and have poor reliability, in part because energetic electrons bury themselves in the ceramic causing a buildup of charge and eventual puncture, and also because large diameter ceramics are difficult to braze reliably. The lifetimes of photo cathodes inside high current DC guns exhibiting field emission are limited to less than a hundred hours. Reducing the surface gradients on the metals reduces the field emission, which serves to maintain the required ultrahigh vacuum condition. A novel gun design with gradients around 5 MV/m and operating at 350 kV, a major improvement over existing designs, was proposed that allows for the in-situ replacement of photo cathodes in axially symmetric designs using inverted ceramics. In this project, the existing JLAB CEBAF asymmetric gun design with an inverted ceramic support was modeled and the beam dynamics characterized. An improved structure was designed that reduces the surface gradients and improves the beam optics. To minimize the surface gradients, a number of electrostatic gun designs were studied to determine the optimum configuration of the critical electrodes within the gun structure. Coating experiments were carried out to create a charge dissipative coating for cylindrical ceramics. The phase II proposal, which was not granted, included the design and fabrication of an axially symmetric DC Gun with an inverted ceramic that would operate with less than 5 MV/m at 350 kV and would be designed with an in-situ replaceable photo-cathode.

  11. Developing fair compensation structures

    International Nuclear Information System (INIS)

    Trousdale, W.J.

    1998-01-01

    The issue of finding an effective way to incorporate Aboriginal values into the process of developing fair compensation structures was discussed. This paper discusses pricing intangible values using dollars, but it was emphasized that 'values' are whatever are important to us. Therefore, in order to achieve fair compensation, creative alternatives that are value-focused should be pursued. In addition to the more straight-forward monetary compensation, compensation could also be about avoiding losses, mitigating adverse impacts, achieving better communication, and promoting cultural understanding. 25 refs., 2 tabs

  12. Low Energy Electron Gun on Board a Scientific Satellite GEOTAIL

    OpenAIRE

    TSUTSUI, Minoru; ONISHI, Yoshiaki; MATSUMOTO, Hiroshi; KIMURA, Iwane; 筒井, 稔; 大西, 嘉昭; 松本, 紘; 木村, 磐根

    1988-01-01

    A low energy electron gun to be used for beam-plasma interaction experiments by a scientific satellite GEOTAIL has been designed and manufactured. Electrodes of the gun have been modified from the Pierce type gun because of the use of a directly heated cathode. Spatial density distributions of beam electrons emitted from the new gun have been measured in a large vacuum chamber, and characteristic curves of emission currents for some beam energies and cathode powers have been checked repeatedl...

  13. Gun utopias? Firearm access and ownership in Israel and Switzerland

    OpenAIRE

    Rosenbaum, Janet

    2011-01-01

    The 2011 attempted assassination of a US representative renewed the national gun control debate. Gun advocates claim that mass-casualty events are mitigated and deterred with three policies: (1) permissive gun laws, (2) widespread gun ownership, (3) encouragement of armed civilians who can intercept shooters, and cite Switzerland and Israel as exemplars. We evaluate these claims with analysis of International Crime Victimization Survey (ICVS) data and translation of laws and original source m...

  14. Trapping of gun-injected plasma by a tokamak

    International Nuclear Information System (INIS)

    Leonard, A.W.; Dexter, R.N.; Sprott, J.C.

    1986-01-01

    It is shown that a plasma produced by a Marshall gun can be injected into and trapped by a tokamak plasma. Gun injection raises the line-averaged density and peaks the density profile. Trapping of the gun-injected plasma is explainable in terms of a depolarization current mechanism

  15. Should Gun Safety Be Taught in Schools? Perspectives of Teachers

    Science.gov (United States)

    Obeng, Cecilia

    2010-01-01

    Background: Gun-related injuries and deaths among children occur at disproportionately high rates in the United States. Children who live in homes with guns are the most likely victims. This study describes teachers' views on whether gun safety should be taught to children in the preschool and elementary years. Methods: A total of 150 survey…

  16. Gun Violence and Children: Factors Related To Exposure and Trauma.

    Science.gov (United States)

    Slovak, Karen

    2002-01-01

    Study investigated relationship between access to firearms and parental monitoring on rural youths' exposure to gun violence, and examined the effect of gun violence exposure on mental health. Results indicated a substantial number were exposed to gun violence. Exposure was related to firearm access and parental monitoring. Implications for social…

  17. 78 FR 11902 - Review of Gun Safety Technologies

    Science.gov (United States)

    2013-02-20

    ... DEPARTMENT OF JUSTICE Office of Justice Programs [OJP (NIJ) Docket No. 1615] Review of Gun Safety...'s Plan to reduce gun violence released on January 16, 2013, the U.S. Department of Justice, Office... emerging gun safety technologies and plans to issue a report on the availability and use of those...

  18. Klystron - Space-charge limited flow, guns, Perveance

    International Nuclear Information System (INIS)

    Isagawa, S.

    1999-01-01

    This paper treats Thermionic emission, Cathode as an e - emitter, Space-charge limited effect and 3/2 power law, Perveance, Beam spread due to space charge, Pierce guns, Magnetically immersed guns, Method of gun design including simulations, and Examples, mainly treating E3786, which attendees will operate above 1 MW-CW in a practical exercise course at KEK. (author). 74 refs

  19. A compact electron gun using field emitter array

    International Nuclear Information System (INIS)

    Asakawa, M.R.; Ikeda, A.; Miyabe, N.; Yamaguchi, S.; Kusaba, M.; Tsunawaki, Y.

    2008-01-01

    A compact electron gun using field emitter array has been developed. With a simple triode configuration consisting of FEA, mid-electrode and anode electrode, the electron gun produces a parallel beam with a diameter of 0.5 mm. This electron gun is applicable for compact radiation sources such as Cherenkov free-electron lasers

  20. The design of gridded pierce guns for accelerators

    International Nuclear Information System (INIS)

    True, R.

    1985-01-01

    It is vital to employ ultra-laminar beams in electron linacs to maximize charge transport to the target. This paper presents numerical and experimental design techniques which have led to significant improvements in gridded Pierce guns used in microwave tubes and electron linacs. The paper concludes with two gun/injector concepts which have demonstrated enhanced performance over standard triode Pierce guns

  1. Youth, Guns, and the Juvenile Justice System. Research Report.

    Science.gov (United States)

    Butts, Jeffrey; Coggeshall, Mark; Gouvis, Caterina; Mears, Daniel; Travis, Jeremy; Waul, Michelle; White, Ruth

    This report documents trends in youth gun violence and the response within the justice system, noting the growing variety of data resources available to investigate the effect of new gun laws on youth, communities, and public safety. The first section reviews recent trends, examining the major wave of gun violence in the United States during the…

  2. Study of Control Grid Thermionic Cathode RF Gun

    CERN Document Server

    Xiao, Jin; Ming, Li; Xinfan, Yang; Xumin, Shen; Yanan, Chen; Zhou, Xu

    2004-01-01

    In this paper, the beam loading effect of RF Gun was analyzed. To minimize the energy spread, the grid control RF Gun was introduced. The result shows that the grid congrol RF Gun can increase electron beam within 1% energy spread.

  3. Cooperation, compensation and transition

    NARCIS (Netherlands)

    Ju, Y.

    2004-01-01

    Cooperation and compensation are two important and well-linked issues in economics. The central question in cooperation is how to share the joint gains among participating players. Compensation is a specific aspect of surplus sharing problems providing incentives for agents to sacrifice their own

  4. Options in Compensation

    DEFF Research Database (Denmark)

    Flor, Christian Riis; Frimor, Hans; Munk, Claus

    2014-01-01

    We derive the optimal compensation contract in a principal–agent setting in which outcome is used to provide incentives for both effort and risky investments. To motivate investment, optimal compensation entails rewards for high as well as low outcomes, and it is increasing at the mean outcome...

  5. 78 FR 66840 - Revocation of Certain Requirements Pertaining to Caps Intended for Use With Toy Guns and Toy Guns...

    Science.gov (United States)

    2013-11-07

    ... Certain Requirements Pertaining to Caps Intended for Use With Toy Guns and Toy Guns Not Intended for Use With Caps AGENCY: Consumer Product Safety Commission. ACTION: Final rule. SUMMARY: Section 106 of the... regulations pertaining to caps intended for use with toy guns refer to obsolete equipment, but the ASTM F963...

  6. Reconnection conditions for a coaxial plasma gun

    International Nuclear Information System (INIS)

    Berk, H.L.; Hammer, J.H.; Shearer, J.W.

    1982-01-01

    A fluid model for the flow conditions necessary to form a compact torus from the plasma ejected by a coaxial plasma gun is developed. This is done by finding the conditions for which the steady-flow equations break down. Results are found for two cases; variable external flux and variable outer-wall radius

  7. Electron gun for the positron generator

    International Nuclear Information System (INIS)

    Fukuda, S.; Ogawa, Y.; Saito, Y.

    1986-01-01

    A triode electron gun has been installed on the Positron Generator at KEK, and brought into test operation. It involves a grid-cathode assembly currently used in a planner triode. The cathode has a diameter of 10 mm and is coated with Ba-Sr-Ca oxide. Because of the short grid-cathode distance (0.18 mm), the relatively low grid pulse voltages makes it possible to draw a high current. The assembly has a small vacuum flange which allows its easy replacement. Emission current from the oxide cathode is sensitive to residual gases, therefore, the vacuum system is carefully made and the pressure is kept in the range of 10 -9 Torr even when the accelerator is on. The grid pulser is a line type pulser using multi-stage avalanche transistors as a switch. The pulse width of 10 nsec has been used for the test to investigate the gun characteristics. The performance of the gun has been tested with this pulser and the emission current of 9.7 A was achieved at an injection voltage of 110 kV. The characteristics of the gun are described together with the beam trace

  8. Guns on Campus: A Chilling Effect

    Science.gov (United States)

    Mash, Kenneth M.

    2013-01-01

    The author of this article observes that, while much has been written on the overall topic of safety with regard to allowing guns on college campuses, little has been said about how allowing the possession of deadly weapons can create a "chilling effect" on academic discussions. This article considers how some universities have…

  9. College Students Opinions on Gun Violence.

    Science.gov (United States)

    Lewis, Rhonda K; LoCurto, Jamie; Brown, Kyrah; Stowell, David; Maryman, J'Vonnah; Dean, Amber; McNair, Thoi; Ojeda, Debbie; Siwierka, Julia

    2016-06-01

    Gun violence and control issues have become serious public health problems. This study gathered the opinions from 419 college students from a Midwestern University. Participants were asked about beliefs about purchasing assault weapons, beliefs about bringing handguns to college campuses and beliefs about contributing factors that lead to gun violence. Participants completed surveys online. The findings showed that overall 54 % of respondents believed that military assault weapons should be banned and 53 % agree that teachers should be allowed to carry a registered handgun on campus. There were statistically significant differences between males and females on these issues. For instance, females believed military assault weapons and high capacity magazines should be banned more than 1.9 times (p = .004) p gun violence were decline in parenting and family values (17 %), gang involvement (14 %), bullying (13.8 %) and guns being easy to obtain (13.8 %). Limitations and implications for policy work are discussed.

  10. Cerebral damage caused by nail gun injury

    Directory of Open Access Journals (Sweden)

    Andersen Chris Hedeman

    2016-06-01

    Full Text Available Background Accidents with nail guns are rather common, especially in the construction industry. Most injuries involve the extremities and several present with intracerebral injuries. When the patient is unconscious, it can be a big challenge to determine whether the injury is an accident, self-inflicted or a criminal act.

  11. A device for electron gun emittance measurement

    International Nuclear Information System (INIS)

    Aune, B.; Corveller, P.; Jablonka, M.; Joly, J.M.

    1985-05-01

    In order to improve the final emittance of the beam delivered by the ALS electron linac a new gun is going to be installed. To measure its emittance and evaluate the contribution of different factors to emittance growth we have developed an emittance measurement device. We describe the experimental and mathematical procedure we have followed, and give some results of measurements

  12. Development of the Antares electron gun

    International Nuclear Information System (INIS)

    Stine, R.; Leland, W.; Mansfield, C.; Rosocha, L.; Jansen, J.; Gibson, R.; Allen, G.

    1984-01-01

    Antares is the Los Alamos National Laboratory 40-kJ, 1-ns, CO 2 laser system that is now operational. This laser system was developed for the Intertial Confinement Fusion (ICF) program and is beginning target experiments. The distributed circuit modeling, design and operation of the large electron gun developed for the final laser power amplifier are reviewed. This gun is significant because of the large electron current area, 9 m 2 ; the number of emitter blades, 48; the dual cathode current return; and the coaxial geometry and grid control. The gun components and their development are discussed. These include the emitter blades, the coaxial grid (to maintain constant electron current during the 5-μs pulse), the bonded stacked-ring insulator (to electrically insulate the grid/cathode), the Kapton/aluminum electron transmission windows (to provide an interface between gun vacuum and laser gas) and the vacuum shell (operated at a vacuum of 10 -6 torr). A unique pressure diagnostic is also discussed

  13. Capital Punishment, Gun Ownership, and Homicide.

    Science.gov (United States)

    Kleck, Gary

    1979-01-01

    Examines two controversial questions related to the problem of interpersonal violence in America: (1) Does use of the death penalty exert any measurable influence on the rate of homicide in the United States? (2) What relationship, if any, exists between the level of gun ownership and the level of homicide violence? (Author)

  14. Traveling-wave synchronous coil gun

    International Nuclear Information System (INIS)

    Elliott, D.G.

    1991-01-01

    This paper reports on a traveling-wave synchronous coil gun which permits independent adjustment of the magnetic field and armature current for high velocity at low armature mass fraction. Magnetic field energy is transferred from the rear of the wave to the front without passing through the power supply. Elaborate switching is required

  15. A high current high frequency ions gun

    International Nuclear Information System (INIS)

    Coutant, J.; Prevot, F.; Vienet, R.

    1959-01-01

    A 10 mA protons gun has been developed for different purposes. The first part of the report studies the plasma production with a RF electromagnetic field. Then the ion extraction process is analysed with particular reference to space charge phenomena. The last part describes a three electrode electrostatic lens which focusses the beam. (author) [fr

  16. Performance of photocathode rf gun electron accelerators

    International Nuclear Information System (INIS)

    Ben-Zvi, I.

    1993-01-01

    In Photo-Injectors (PI) electron guns, electrons are emitted from a photocathode by a short laser pulse and then accelerated by intense rf fields in a resonant cavity. The best known advantage of this technique is the high peak current with a good emittance (high brightness). This is important for short wavelength Free-Electron Lasers and linear colliders. PIs are in operation in many electron accelerator facilities and a large number of new guns are under construction. Some applications have emerged, providing, for example, very high pulse charges. PIs have been operated over a wide range of frequencies, from 144 to 3000 MHz (a 17 GHz gun is being developed). An exciting new possibility is the development of superconducting PIs. A significant body of experimental and theoretical work exists by now, indicating the criticality of the accelerator elements that follow the gun for the preservation of the PI's performance as well as possible avenues of improvements in brightness. Considerable research is being done on the laser and photocathode material of the PI, and improvement is expected in this area

  17. How Sociology Texts Address Gun Control

    Science.gov (United States)

    Tonso, William R.

    2004-01-01

    William R. Tonso has chosen an issue that he knows something about to examine how sociology textbooks address controversy. Appealing for gun control is fashionable, but it is at odds with a fondness that ordinary Americans have for their firearms--one that is supported by a growing body of research on deterrence to crime. There are two sides to…

  18. Green plasticizers for multibase gun propellants (Lecture)

    NARCIS (Netherlands)

    Schoolderman, C.; Driel, C.A. van; Zebregs, M.

    2007-01-01

    TNO Defence, Security and Safety has a long history of research on gun propellants. Areas investigated are formulating (new ingredients, optimization), manufacturing, charge design and lifetime assessment [1,2,3,4,5]. In conventional propellants inert plasticizers are used to alter performance,

  19. The electron gun for the Daresbury SRS linac

    International Nuclear Information System (INIS)

    Dykes, D.M.

    1996-01-01

    The electron gun for the Daresbury SRS linac injector has been modified to use the cathode-grid assembly from the Eimac planar triode 8755. The gun now has improved beam characteristics, is more reliable and the cathode assembly is quicker and easier to change. This paper describes the assembly of the electron gun, and then the re-conditioning of the cathode highlighting the vacuum environment. The action of the grid modulation system on the electron beam, which pre-bunches the electron beam, is described, and typical gun characteristics are shown. Proposed developments to the gun system are discussed. (author)

  20. Performance of a carbon nanotube field emission electron gun

    Science.gov (United States)

    Getty, Stephanie A.; King, Todd T.; Bis, Rachael A.; Jones, Hollis H.; Herrero, Federico; Lynch, Bernard A.; Roman, Patrick; Mahaffy, Paul

    2007-04-01

    A cold cathode field emission electron gun (e-gun) based on a patterned carbon nanotube (CNT) film has been fabricated for use in a miniaturized reflectron time-of-flight mass spectrometer (RTOF MS), with future applications in other charged particle spectrometers, and performance of the CNT e-gun has been evaluated. A thermionic electron gun has also been fabricated and evaluated in parallel and its performance is used as a benchmark in the evaluation of our CNT e-gun. Implications for future improvements and integration into the RTOF MS are discussed.

  1. Acute Alcohol Consumption, Alcohol Outlets, and Gun Suicide

    Science.gov (United States)

    Branas, Charles C.; Richmond, Therese S.; Ten Have, Thomas R.; Wiebe, Douglas J.

    2014-01-01

    A case–control study of 149 intentionally self-inflicted gun injury cases (including completed gun suicides) and 302 population-based controls was conducted from 2003 to 2006 in a major US city. Two focal independent variables, acute alcohol consumption and alcohol outlet availability, were measured. Conditional logistic regression was adjusted for confounding variables. Gun suicide risk to individuals in areas of high alcohol outlet availability was less than the gun suicide risk they incurred from acute alcohol consumption, especially to excess. This corroborates prior work but also uncovers new information about the relationships between acute alcohol consumption, alcohol outlets, and gun suicide. Study limitations and implications are discussed. PMID:21929327

  2. Development of the electron gun control system of SSRF

    International Nuclear Information System (INIS)

    Zhou Dayong; Lin Guoqiang; Liu Dekang; Shen Liren

    2010-01-01

    An electron gun is the key part of a linac, the beam quality of which depends on beam quality of the electron gun, hence the need of a stable control system of the electron gun to ensure its safe operation.In this paper, we report our progresses in developing the linac's electron gun control system of Shanghai Synchrotron Radiation Facility (SSRF). It uses PLC as the device controllers, with the monitoring software developed on EPICS. The whole system is connected by Ethernet. The PLC and Ethernet technology ensures good reliability and easy maintenance of the electron gun control system. (authors)

  3. Phenolic excipients of insulin formulations induce cell death, pro-inflammatory signaling and MCP-1 release

    Directory of Open Access Journals (Sweden)

    Claudia Weber

    2015-01-01

    Insulin solutions displayed cytotoxic and pro-inflammatory potential caused by phenol or m-cresol. We speculate that during insulin pump therapy phenol and m-cresol might induce cell death and inflammatory reactions at the infusion site in vivo. Inflammation is perpetuated by release of MCP-1 by activated monocytic cells leading to enhanced recruitment of inflammatory cells. To minimize acute skin complications caused by phenol/m-cresol accumulation, a frequent change of infusion sets and rotation of the infusion site is recommended.

  4. Physical, chemical and sensory changes of refrigerated yellow pitahaya treated preharvest with 1-MCP

    OpenAIRE

    Liliana Serna Cock; Laura Sofía Torres Valenzuela; Alfredo Ayala Aponte

    2013-01-01

    El efecto de la aplicación de soluciones acuosas de 0, 200 y 400 mg L de 1-metilciclopropeno (1-MCP) en pitahaya amarilla en precosecha (Selenicereus megalanthus Haw) fue evaluado. Se midieron los cambios en pérdida de peso, cambio total de la coloración, azucares totales, acidez titulable, ácido ascórbico y análisis sensorial. La pitahaya fue almacenada bajo refrigeración (10°C y 85% de humedad relativa por 29 días). Dos tipos de empaque (Cajas para exportación y canastillas plá...

  5. 6D Phase Space Measurements at the SLAC Gun Test Facility

    CERN Document Server

    Schmerge, J

    2003-01-01

    Proposed fourth generation light sources using SASE FELs to generate short pulse, coherent X-rays require demonstration of high brightness electron sources. The Gun Test Facility (GTF) at SLAC was built to test high brightness sources for the proposed Linac Coherent Light Source at SLAC. The GTF is composed of an Sband photocathode rf gun with a Cu cathode, emittance compensating solenoid, single 3 m SLAC linac section and e-beam diagnostic section with a UV drive laser system. The longitudinal emittance exiting the gun has been determined by measuring the energy spectrum downstream of the linac as a function of the linac phase. The e-beam pulse width, correlated and uncorrelated energy spread at the linac entrance have been fit to the measured energy spectra using a least square error fitting routine. The fit yields a pulse width of 2.9 ps FWHM for a 4.3 ps FWHM laser pulse width and 2% rms correlated energy spread with 0.07% rms uncorrelated energy spread. The correlated energy spread is enhanced in the lin...

  6. Patterns of gun deaths across US counties 1999-2013.

    Science.gov (United States)

    Kalesan, Bindu; Galea, Sandro

    2017-05-01

    We examined the socio-demographic distribution of gun deaths across 3143 counties in 50 United States' states to understand the spatial patterns and correlates of high and low gun deaths. We used aggregate counts of gun deaths and population in all counties from 1999 to 2013 from the Centers for Disease Control and Prevention's Wide-ranging Online Data for Epidemiologic Research (WONDER). We characterized four levels of gun violence, as distinct levels of gun death rates of relatively safe, unsafe, violent, and extremely violent counties, based on quartiles of 15-year county-specific gun death rates per 100,000 and used negative binomial regression models allowing clustering by state to calculate incidence rate ratios and 95% confidence intervals (95% CIs). Most states had at least one violent or extremely violent county. Extremely violent gun counties were mostly rural, poor, predominantly minority, had high unemployment rate and homicide rate. Overall, homicide rate was significantly associated with gun deaths (incidence rate ratios = 1.08, 95% CI = 1.06-1.09). In relatively safe counties, this risk was 1.09 (95% CI = 1.05-1.13) and in extremely violent gun counties was 1.03 (95% CI = 1.03-1.04). There are broad differences in gun death rates across the United States representing different levels of gun death rates in each state with distinct socio-demographic profiles. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. Association Between Substance Use and Gun-Related Behaviors.

    Science.gov (United States)

    Chen, Danhong; Wu, Li-Tzy

    2016-01-01

    Gun-related violence is a public health concern. This study synthesizes findings on associations between substance use and gun-related behaviors. Searches through PubMed, Embase, and PsycINFO located 66 studies published in English between 1992 and 2014. Most studies found a significant bivariate association between substance use and increased odds of gun-related behaviors. However, their association after adjustment was mixed, which could be attributed to a number of factors such as variations in definitions of substance use and gun activity, study design, sample demographics, and the specific covariates considered. Fewer studies identified a significant association between substance use and gun access/possession than other gun activities. The significant association between nonsubstance covariates (e.g., demographic covariates and other behavioral risk factors) and gun-related behaviors might have moderated the association between substance use and gun activities. Particularly, the strength of association between substance use and gun activities tended to reduce appreciably or to become nonsignificant after adjustment for mental disorders. Some studies indicated a positive association between the frequency of substance use and the odds of engaging in gun-related behaviors. Overall, the results suggest a need to consider substance use in research and prevention programs for gun-related violence. © The Author 2016. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  8. Gun utopias? Firearm access and ownership in Israel and Switzerland.

    Science.gov (United States)

    Rosenbaum, Janet E

    2012-02-01

    The 2011 attempted assassination of a US representative renewed the national gun control debate. Gun advocates claim mass-casualty events are mitigated and deterred with three policies: (a) permissive gun laws, (b) widespread gun ownership, (c) and encouragement of armed civilians who can intercept shooters. They cite Switzerland and Israel as exemplars. We evaluate these claims with analysis of International Crime Victimization Survey (ICVS) data and translation of laws and original source material. Swiss and Israeli laws limit firearm ownership and require permit renewal one to four times annually. ICVS analysis finds the United States has more firearms per capita and per household than either country. Switzerland and Israel curtail off-duty soldiers' firearm access to prevent firearm deaths. Suicide among soldiers decreased by 40 per cent after the Israeli army's 2006 reforms. Compared with the United States, Switzerland and Israel have lower gun ownership and stricter gun laws, and their policies discourage personal gun ownership.

  9. Progress on a cryogenically cooled RF gun polarized electron source

    Energy Technology Data Exchange (ETDEWEB)

    Fliller, R.P., III; Edwards, H.; /Fermilab

    2006-08-01

    RF guns have proven useful in multiple accelerator applications. An RF gun capable of producing polarized electrons is an attractive electron source for the ILC or an electron-ion collider. Producing such a gun has proven elusive. The NEA GaAs photocathode needed for polarized electron production is damaged by the vacuum environment in an RF gun. Electron and ion back bombardment can also damage the cathode. These problems must be mitigated before producing an RF gun polarized electron source. In this paper we report continuing efforts to improve the vacuum environment in a normal conducting RF gun by cooling it with liquid nitrogen after a high temperature vacuum bake out. We also report on a design of a cathode preparation chamber to produce bulk GaAs photocathodes for testing in such a gun. Future directions are also discussed.

  10. Temporal cascade of inflammatory cytokines and cell-type populations in monocyte chemotactic protein-1 (MCP-1)-mediated aneurysm healing.

    Science.gov (United States)

    Hoh, Brian L; Fazal, Hanain Z; Hourani, Siham; Li, Mengchen; Lin, Li; Hosaka, Koji

    2018-03-01

    We have previously shown that monocyte chemotactic protein-1 (MCP-1) promotes aneurysm healing. To determine the temporal cascade and durability of aneurysm healing. Murine carotid aneurysms were treated with MCP-1-releasing or poly(lactic-co-glycolic) acid (PLGA)-only coils. Aneurysm healing was assessed by quantitative measurements of intraluminal tissue ingrowth on 5 μm sections by blinded observers. Aneurysm healing occurred in stages characteristic of normal wound healing. The 1st stage (day 3) was characterized by a spike in neutrophils and T cells. The 2nd stage (week 1) was characterized by an influx of macrophages and CD45+ cells significantly greater with MCP-1 than with PLGA (p<0.05). The third stage (week 2-3) was characterized by proliferation of smooth muscle cells and fibroblasts (greater with MCP-1 than with PLGA, p<0.05). The fourth stage (3-6 months) was characterized by leveling off of smooth muscle cells and fibroblasts. M1 macrophages were greater at week 1, whereas M2 macrophages were greater at weeks 2 and 3 with MCP-1 than with PLGA. Interleukin 6 was present early and increased through week 2 (p<0.05 compared with PLGA) then decreased and leveled off through 6 months. Tumour necrosis factor α was present early and remained constant through 6 months. MCP-1 and PLGA treatment had similar rates of tissue ingrowth at early time points, but MCP-1 had a significantly greater tissue ingrowth at week 3 (p<0.05), which persisted for 6 months. The sequential cascade is consistent with an inflammatory model of injury, repair, and remodeling. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  11. The roles of MCP-1 and protein kinase C delta activation in human eosinophilic leukemia EoL-1 cells.

    Science.gov (United States)

    Lee, Ji-Sook; Yang, Eun Ju; Kim, In Sik

    2009-12-01

    Idiopathic hypereosinophilc syndrome is a disorder associated with clonally eosinophilic proliferation. The importance of FIP1-like-1-platelet-derived growth factor receptor-alpha (FIP1L1-PDGFRA) in the pathogenesis and classification of HES has been recently reported. In this study, we investigated the contribution of monocyte chemoattractant protein-1 (MCP-1)/CCL2 to chemotactic activity and protein kinase C delta (PKC delta in the human eosinophilic leukemia cell line EoL-1. These cells express CCR2 protein among the CC chemokine receptors (CCR1-5). MCP-1 induces strong migration of EoL-1 cells and the chemotaxis signal in response to MCP-1 involves a G(i)/G(o) protein, phospholipase C (PLC), PKC delta, p38 MAPK and NF-kappaB. MCP-1 activates p38 MAPK via G(i)/G(o) protein, PLC and PKC delta cascade. MCP-1 also induces NF-kappaB translocation and the activation is inhibited by PKC delta activation. The increase in the basal expression and activity of PKC delta in EoL-1 cells, compared to normal eosinophils, inhibits apoptosis in EoL-1 cells. Anti-apoptotic mechanism of PKC delta is related to inhibition of caspase 3 and caspase 9, but not to FIP1L1-PDGFRA. PKC delta functions as an anti-apoptotic molecule, and is involved in EoL-1 cell movement stimulated by MCP-1. This study contributes to an understanding of MCP-1 in eosinophil biology and pathogenic mechanism of eosinophilic disorders.

  12. Myocardial production and release of MCP-1 and SDF-1 following myocardial infarction: differences between mice and man

    Directory of Open Access Journals (Sweden)

    Palasubramaniam Dharshan

    2011-09-01

    Full Text Available Abstract Background Stem cell homing to the heart is mediated by the release of chemo-attractant cytokines. Stromal derived factor -1 alpha (SDF-1a and monocyte chemotactic factor 1(MCP-1 are detectable in peripheral blood after myocardial infarction (MI. It remains unknown if they are produced by, and released from, the heart in order to attract stem cells to repair the damaged myocardium. Methods Murine hearts were studied for expression of MCP-1 and SDF-1a at day 3 and day 28 following myocardial infarction to determine whether production is increased following MI. In addition, we studied the coronary artery and coronary sinus (venous blood from patients with normal coronary arteries, stable coronary artery disease (CAD, unstable angina and MI to determine whether these cytokines are released from the heart into the systemic circulation following MI. Results Both MCP-1 and SDF-1a are constitutively produced and released by the heart. MCP-1 mRNA is upregulated following murine experimental MI, but SDF-1a is suppressed. There is less release of SDF-1a into the systemic circulation in patients with all stages of CAD including MI, mimicking the animal model. However MCP-1 release from the human heart following MI is also suppressed, which is the exact opposite of the animal model. Conclusions SDF-1a and MCP-1 release from the human heart are suppressed following MI. In the case of SDF-1a, the animal model appropriately reflects the human situation. However, for MCP-1 the animal model is the exact opposite of the human condition. Human observational studies like this one are paramount in guiding translation from experimental studies to clinical trials.

  13. Atraso do amadurecimento de banana 'Maçã' pelo 1-MCP, aplicado previamente à refrigeração Ripening delay of 'Apple' banana submitted to 1-MCP, prevoiously applied to refrigeration

    Directory of Open Access Journals (Sweden)

    Gustavo Costa Almeida

    2006-08-01

    Full Text Available O objetivo deste trabalho foi avaliar o efeito de diferentes períodos de exposição da banana 'Maçã' a 50 ppb de 1-MCP (0; 3; 6; 9; 12 e 24 horas sobre sua vida pós-colheita e qualidade. Após exposição ao 1-MCP, os frutos verde-maturos foram armazenados por 30 dias em câmaras com temperatura de 13ºC ± 0,5 e umidade relativa de 95%. Em seguida, as bananas foram armazenadas à temperatura de 20ºC ± 1, até amarelecimento completo da casca. A exposição de banana 'Maçã' a 50 ppb de 1-MCP, por 9 horas, retardou em 7 dias o seu amadurecimento, em comparação a frutos não expostos ao 1-MCP, após 30 dias de armazenamento refrigerado (13ºC, sem prejuízos à sua aparência e composição química. A exposição de banana 'Maçã' a 50 ppb de 1-MCP, por 3 e 6 horas, não estendeu sua vida pós-colheita, tampouco alterou sua composição química. Embora a exposição de banana 'Maçã' a 50 ppb de 1-MCP, por 12 e 24 horas, tenha retardado o seu amadurecimento, promoveu alterações indesejáveis na casca do fruto. Logo, a aplicação de 50 ppb de 1-MCP, por 9 horas, antes da refrigeração, constitui-se numa alternativa viável para prolongar o período de comercialização da banana.The aim of this work was to evaluate 'Apple' banana different periods exposure effect to 50 ppb of 1-MCP (0, 3, 6, 9 and 24 hours on its postharvest life and quality. Mature-green fruits were stored for 30 days in chambers at 13ºC + 0,5 and relative humidity 95%, after exposure to 1-MCP. Then, the bananas were stored at 20ºC + 1 until peel complete yellowing. 'Apple' banana to 50 ppb of 1-MCP exposure during 9 hours delayed in seven days the fruit ripening, comparing to fruit control, after 30 days of cool storage (13ºC, without changing its appearance and chemical composition. The exposure of 'Apple' banana to 50 ppb of 1-MCP for 3 and 6 hours did not extend its postharvest life; neither changed its chemical composition. Although the exposure of

  14. RETARDAMENTO DA MATURAÇÃO DE MAÇÃS 'FUJI' PELO TRATAMENTO COM 1-MCP E MANEJO DA TEMPERATURA DELAYING 'FUJI' APPLE RIPENING BY 1-MCP TREATMENT AND MANAGEMENT OF STORAGE TEMPERATURE

    Directory of Open Access Journals (Sweden)

    LUIZ CARLOS ARGENTA

    2001-08-01

    Full Text Available Maçãs cv. Fuji foram tratadas com 42 mimol·m-3 de 1-metilciclopropeno (1-MCP por 24 h a 20°C, um dia após a colheita, e então armazenadas a 0; 10 ou 20ºC por 70 dias. Tratamento com 1-MCP efetivamente retardou a maturação de maçãs 'Fuji'. 1-MCP reduziu a taxa respiratória dos frutos mantidos a 10 e 20ºC e inibiu a produção de etileno dos frutos mantidos nas três temperaturas de armazenagem. Frutos tratados com 1-MCP e armazenados a 20ºC exibiram taxas respiratórias similares ou inferiores àquelas de frutos-controle armazenados a 10ºC. Quando armazenados a 10 ou 20ºC, frutos tratados com 1-MCP preservaram mais a firmeza da polpa e a acidez titulável e exibiram menor amarelecimento da epiderme que frutos-controle. Entretanto, não houve benefícios significativos do tratamento 1-MCP sobre a conservação da qualidade dos frutos armazenados a 0ºC no período de 70 dias após a colheita. Os resultados indicam que o tratamento com 1-MCP pode ser uma estratégia para o aumento da conservação de maçãs cv. Fuji durante o transporte e a distribuição sob 10 ou 20ºC. O prolongamento da armazenagem a 20ºC por período superior a 40 dias pode ser limitado pelo murchamento dos frutos e desenvolvimento de podridões.'Fuji' apples were treated with 42 mumol·m-3 of 1-methylcyclopropene (1-MCP for 24 h at 20°C then stored at 0, 10 or 20 ºC for 70 days. MCP treatment reduced respiration on fruit held at 10 and 20 ºC and inhibited ethylene production regardless of storage temperature. Treated fruits held at 20ºC presented respiration rate similar to those of untreated fruits held at 10ºC. For fruit held at 10 or 20ºC, MCP treatment inhibited softening, loss of acidity and color changes on fruit surface. However, there was no considerable benefit of 1-MCP treatment on maintenance of fruit quality during short-term (70 days and storage at 0ºC. Results indicated that 1-MCP is an effective mean to delay ripening and to retain

  15. The human MCP-2 gene (SCYA8): Cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2

    Energy Technology Data Exchange (ETDEWEB)

    Van Coillie, E.; Fiten, P.; Van Damme, J.; Opdenakker, G. [Univ. of Leuven (Belgium)] [and others

    1997-03-01

    Monocyte chemotactic proteins (MCPs) form a subfamily of chemokines that recruit leukocytes to sites of inflammation and that may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. With the use of degenerate primers that were based on CC chemokine consensus sequences, the known MIP-1{alpha}/LD78{alpha}, MCP-1, and MCP-3 genes and the previously unidentified eotaxin and MCP-2 genes were isolated from a YAC contig from human chromosome 17q11.2. The amplified genomic MCP-2 fragment was used to isolate an MCP-2 cosmid from which the gene sequence was determined. The MCP-2 gene shares with the MCP-1 and MCP-3 genes a conserved intron-exon structure and a coding nucleotide sequence homology of 77%. By Northern blot analysis the 1.0-kb MCP-2 mRNA was predominantly detectable in the small intestine, peripheral blood, heart, placenta, lung, skeletal muscle, ovary, colon, spinal cord, pancreas, and thymus. Transcripts of 1.5 and 2.4 kb were found in the testis, the small intestine, and the colon. The isolation of the MCP-2 gene from the chemokine contig localized it on YAC clones of chromosome 17q11.2, which also contain the eotaxin, MCP-1, MCP-3, and NCC-1/MCP-4 genes. The combination of using degenerate primer PCR and YACs illustrates that novel genes can efficiently be isolated from gene cluster contigs with less redundancy and effort than the isolation of novel ESTs. 42 refs., 5 figs., 2 tabs.

  16. Reactive power compensator

    Science.gov (United States)

    El-Sharkawi, Mohamed A.; Venkata, Subrahmanyam S.; Chen, Mingliang; Andexler, George; Huang, Tony

    1992-01-01

    A system and method for determining and providing reactive power compensation for an inductive load. A reactive power compensator (50,50') monitors the voltage and current flowing through each of three distribution lines (52a, 52b, 52c), which are supplying three-phase power to one or more inductive loads. Using signals indicative of the current on each of these lines when the voltage waveform on the line crosses zero, the reactive power compensator determines a reactive power compensator capacitance that must be connected to the lines to maintain a desired VAR level, power factor, or line voltage. Alternatively, an operator can manually select a specific capacitance for connection to each line, or the capacitance can be selected based on a time schedule. The reactive power compensator produces control signals, which are coupled through optical fibers (102/106) to a switch driver (110, 110') to select specific compensation capacitors (112) for connections to each line. The switch driver develops triggering signals that are supplied to a plurality of series-connected solid state switches (350), which control charge current in one direction in respect to ground for each compensation capacitor. During each cycle, current flows from ground to charge the capacitors as the voltage on the line begins to go negative from its positive peak value. The triggering signals are applied to gate the solid state switches into a conducting state when the potential on the lines and on the capacitors reaches a negative peak value, thereby minimizing both the potential difference and across the charge current through the switches when they begin to conduct. Any harmonic distortion on the potential and current carried by the lines is filtered out from the current and potential signals used by the reactive power compensator so that it does not affect the determination of the required reactive compensation.

  17. Reactive power compensator

    Energy Technology Data Exchange (ETDEWEB)

    El-Sharkawi, Mohamed A. (Renton, WA); Venkata, Subrahmanyam S. (Woodinville, WA); Chen, Mingliang (Kirkland, WA); Andexler, George (Everett, WA); Huang, Tony (Seattle, WA)

    1992-01-01

    A system and method for determining and providing reactive power compensation for an inductive load. A reactive power compensator (50,50') monitors the voltage and current flowing through each of three distribution lines (52a, 52b, 52c), which are supplying three-phase power to one or more inductive loads. Using signals indicative of the current on each of these lines when the voltage waveform on the line crosses zero, the reactive power compensator determines a reactive power compensator capacitance that must be connected to the lines to maintain a desired VAR level, power factor, or line voltage. Alternatively, an operator can manually select a specific capacitance for connection to each line, or the capacitance can be selected based on a time schedule. The reactive power compensator produces control signals, which are coupled through optical fibers (102/106) to a switch driver (110, 110') to select specific compensation capacitors (112) for connections to each line. The switch driver develops triggering signals that are supplied to a plurality of series-connected solid state switches (350), which control charge current in one direction in respect to ground for each compensation capacitor. During each cycle, current flows from ground to charge the capacitors as the voltage on the line begins to go negative from its positive peak value. The triggering signals are applied to gate the solid state switches into a conducting state when the potential on the lines and on the capacitors reaches a negative peak value, thereby minimizing both the potential difference and across the charge current through the switches when they begin to conduct. Any harmonic distortion on the potential and current carried by the lines is filtered out from the current and potential signals used by the reactive power compensator so that it does not affect the determination of the required reactive compensation.

  18. MCP-1, ICAM-1 and VCAM-1 are present in early aneurysmal dilatation in experimental rats

    International Nuclear Information System (INIS)

    Jun Fan; Hao-Tong; Jing Di; Fang Liu; Hai-Hua Zhao; Shu-Ling Bai; Xiang Li; Linlin Zhong

    2010-01-01

    Recent studies have suggested that inflammation actively participates in ascending aortic aneurysm formation. The aim of the present study was to evaluate the expression changes of adhesion molecules and MMPs in an experimental model of ascending aortic aneurysm induced by ascending aorta banding in Wistar rats. Twelve rats developed aortic dilation after ascending aorta banding treatment, while nine normal animals underwent surgery without banding were used as controls. Light microscope and scanning electron microscope showed that the wall of the ascending aorta became disorganized as well as infiltration by inflammatory cells in aneurysmal rats. By using immunohistochemical techniques, a significant increase in the immunostaining of MCP-1 was observed in the aneurysmal wall as compared to the normal aortic wall. Under similar experimental conditions, we also found that the immunostaining of ICAM-1 and VCAM-1 was markedly increased in the aneurysmal wall. In addition, gelatin zymo graphic analysis showed that the expression and activities of MMP-2 and MMP-9 were remarkably enhanced in the ascending aorta of ascending aortic aneurysmal rats as compared to normal rats. These results demonstrate that MCP-1, ICAM-1 and VCAM-1 are involved in the pathogenesis of ascending aortic aneurysm and an increase in the immunostaining and activity of MMP-2 and MMP-9 may promote the progression of ascending aortic aneurysm. (authors)

  19. Fast front-end L0 trigger electronics for ALICE FMD-MCP tests and performance

    CERN Document Server

    Efimov, L G; Kasatkan, V; Klempt, W; Kuts, V; Lenti, V; Platanov, V; Rudge, A; Stolyarov, O I; Tsimbal, F A; Valiev, F F; Villalobos Baillie, O; Vinogradov, L I; Zhigunov, O

    1997-01-01

    We present design details and new measurements of the performance of fast electronics for the Forward Multiplicity Detector for ALICE. These detectors based on sector type Microchannel Plates (MCP) forming several disks gave the very first trigger decision in the experiment (L0). Fast passive summators integrated with the detectors are used for linear summation of up to eight isochronous signal channels from MCP pads belonging to one sector. Two types of microelectronics design thin film summators were produced. We present test results for these summators, working in the frequency range up to 1 Ghz. New low noise preamplifiers have been built to work with these summators. The new design shows a good performance with the usable frequency range extended up to 1 Ghz. An upgrade of the functional scheme for the L0 ALICE pre-trigger design is also presented.Abstract:List of figures Figure 1: ALICE L0 Trigger Front-End Electronics Functional Scheme. Figure 2: UHF design for a fast passive summator based on direct...

  20. TRPV1 and the MCP-1/CCR2 Axis Modulate Post-UTI Chronic Pain.

    Science.gov (United States)

    Rosen, John M; Yaggie, Ryan E; Woida, Patrick J; Miller, Richard J; Schaeffer, Anthony J; Klumpp, David J

    2018-05-08

    The etiology of chronic pelvic pain syndromes remains unknown. In a murine urinary tract infection (UTI) model, lipopolysaccharide of uropathogenic E. coli and its receptor TLR4 are required for post-UTI chronic pain development. However, downstream mechanisms of post-UTI chronic pelvic pain remain unclear. Because the TRPV1 and MCP-1/CCR2 pathways are implicated in chronic neuropathic pain, we explored their role in post-UTI chronic pain. Mice were infected with the E. coli strain SΦ874, known to produce chronic allodynia, and treated with the TRPV1 antagonist capsazepine. Mice treated with capsazepine at the time of SΦ874 infection failed to develop chronic allodynia, whereas capsazepine treatment of mice at two weeks following SΦ874 infection did not reduce chronic allodynia. TRPV1-deficient mice did not develop chronic allodynia either. Similar results were found using novelty-suppressed feeding (NSF) to assess depressive behavior associated with neuropathic pain. Imaging of reporter mice also revealed induction of MCP-1 and CCR2 expression in sacral dorsal root ganglia following SΦ874 infection. Treatment with a CCR2 receptor antagonist at two weeks post-infection reduced chronic allodynia. Taken together, these results suggest that TRPV1 has a role in the establishment of post-UTI chronic pain, and CCR2 has a role in maintenance of post-UTI chronic pain.

  1. Coaxial plasma gun in the high density regime and injection into a helical field

    Energy Technology Data Exchange (ETDEWEB)

    Schaer, S.F. [Ecole Polytechnique Federale, Lausanne (Switzerland). Centre de Recherche en Physique des Plasma (CRPP)

    1994-02-01

    A modified coaxial gun in the high density regime of 20-70 mT of He restgas, energized by a 1200 HV sinusoidally damped capacitor discharge with peak currents of 86 kA in a potential range of 10-15 kV, was investigated. The acceleration of the current sheet inside the gun was studied, and an MHD current element model derived, in good agreement with experiment, indicating that thermal diffusion can be neglected during the acceleration phase and furthermore explains the sheet velocity limitation. At the muzzle the plasma is magnetized by inducing a toroidal current through a permanent radial field, generating poloidal field. The injection of the generated current-carrying plasma torus into the driftspace was studied by means of a diamagnetic probe array, for 1) toroidal bias field, and 2) helical bias field. The inner electrode (negative polarity) is continued into the driftspace by a considerably thinner, pyrex insulated central conductor, generating the toroidal bias. Quasi-Tokamak geometry is reached in the helical case. The necessary axial bias field strength was then calculated. Second half-period breakdown was observed, thus a positive electrode was present most of the time. This is a unique way to achieve autopreionisation. Plasma gun operation is very much breakdown dependent, specially in the region of the muzzle. This made it necessary to construct a special compensation coil for the axial field coil. The mean torus speed in the driftspace was 2.2 cm/{mu}sec. The tori were azimuthally homogeneous and exhibited enhanced stability. Transverse expansion at ejection and in the driftspace is prevented by a unique rarefaction wave-pattern resulting from the Mach 50 flow. The toroidal current was observed to decay continuously, not abruptly. No n type or oscillatory instabilities were encountered. These findings are important for future designs of guns where a stable and homogenous torus is needed, such as magnetic confinement injectors. (author) 39 figs., 38 refs.

  2. Coaxial plasma gun in the high density regime and injection into a helical field

    International Nuclear Information System (INIS)

    Schaer, S.F.

    1994-02-01

    A modified coaxial gun in the high density regime of 20-70 mT of He restgas, energized by a 1200 HV sinusoidally damped capacitor discharge with peak currents of 86 kA in the potential range of 10-15 kV, was investigated. The acceleration of the current sheet inside the gun was studied, and an MHD current element model derived, in good agreement with experiment, indicating that thermal diffusion can be neglected during the acceleration phase and furthermore explains the sheet velocity limitation. At the muzzle the plasma is magnetized by inducing a toroidal current through a permanent radial field, generating poloidal field. The injection of the generated current-carrying plasma torus into the driftspace was studied by means of a diamagnetic probe array, for 1) toroidal bias field, and 2) helical bias field. The inner electrode (negative polarity) is continued into the driftspace by a considerably thinner, pyrex insulated central conductor, generating the toroidal bias. Quasi-Tokamak geometry is reached in the helical case. The necessary axial bias field strength was then calculated. Second half-period breakdown was observed, thus a positive electrode was present most of the time. This is a unique way to achieve autopreionisation. Plasma gun operation is very much breakdown dependent, specially in the region of the muzzle. This made it necessary to construct a special compensation coil for the axial field coil. The mean torus speed in the driftspace was 2.2 cm/μsec. The tori were azimuthally homogeneous and exhibited enhanced stability. Transverse expansion at ejection and in the driftspace is prevented by a unique rarefaction wave-pattern resulting from the Mach 50 flow. The toroidal current was observed to decay continuously, not abruptly. No n type or oscillatory instabilities were encountered. These findings are important for future designs of guns where a stable and homogenous torus is needed, such as magnetic confinement injectors. (author) 39 figs., 38 refs

  3. Climate change and compensation

    DEFF Research Database (Denmark)

    Jensen, Karsten Klint; Flanagan, Tine Bech

    2013-01-01

    This paper presents a case for compensation of actual harm from climate change in the poorest countries. First, it is shown that climate change threatens to reverse the fight to eradicate poverty. Secondly, it is shown how the problems raised in the literature for compensation to some extent...... are based on misconceptions and do not apply to compensation of present actual harm. Finally, two arguments are presented to the effect that, in so far as developed countries accept a major commitment to mitigate climate change, they should also accept a commitment to address or compensate actual harm from...... climate change. The first argument appeals to the principle that if it is an injustice to cause risk of incurring harm in the future, then it is also an injustice to cause a similar harm now. The second argument appeals to the principle that if there is moral reason to reduce the risk of specific harms...

  4. Workers Compensation Claim Data -

    Data.gov (United States)

    Department of Transportation — This data set contains DOT employee workers compensation claim data for current and past DOT employees. Types of data include claim data consisting of PII data (SSN,...

  5. Combined use of serum MCP-1/IL-10 ratio and uterine artery Doppler index significantly improves the prediction of preeclampsia.

    Science.gov (United States)

    Cui, Shihong; Gao, Yanan; Zhang, Linlin; Wang, Yuan; Zhang, Lindong; Liu, Pingping; Liu, Ling; Chen, Juan

    2017-10-01

    Monocyte chemotactic protein-1 (MCP-1, or CCL2) is a member of the chemokine subfamily involved in recruitment of monocytes in inflammatory tissues. IL-10 is a key regulator for maintaining the balance of anti-inflammatory and pro-inflammatory milieu at the feto-maternal interface. Doppler examination has been routinely performed for the monitoring and management of preeclampsia patients. This study evaluates the efficiency of these factors alone, or in combination, for the predication of preeclampsia. The serum levels of MCP-1 and IL-10 in 78 preeclampsia patients and 143 age-matched normal controls were measured. The Doppler ultrasonography was performed and Artery Pulsatility Index (PI) and Resistance Index (RI) were calculated for the same subjects. It was found that while the second-trimester serum MCP-1, IL-10, MCP-1/IL-10 ratio, PI, and RI showed some power in predicting preeclampsia, the combination of MCP-1/IL-10 and PI and RI accomplishes the highest efficiency, achieving an AUC of 0.973 (95% CI, 0.000-1.000, Ppreeclampsia. Future studies using a larger sample can be conducted to construct an algorithm capable of quantitative assessment on the risk of preeclampsia. Copyright © 2016 Elsevier B.V. All rights reserved.

  6. Aplicação de 1-MCP em caqui 'quioto' armazenado sob refrigeração e atmosfera controlada Effect of 1-MCP applied at different times during cold and Ca storage

    Directory of Open Access Journals (Sweden)

    Auri Brackmann

    2003-04-01

    Full Text Available O objetivo deste trabalho foi de avaliar o efeito do 1-MCP aplicado em diferentes épocas durante o armazenamento refrigerado (AR e em atmosfera controlada (AC sobre a qualidade do caqui cv. Quioto. O delineamento experimental utilizado foi o inteiramente casualizado, com quatro repetições de 30 frutos, e os tratamentos foram os seguintes: armazenamento refrigerado (AR; armazenamento refrigerado(AR + 1-MCP (1000ppb no início do armazenamento; armazenamento refrigerado(AR +1-MCP (1000ppb no final do armazenamento; armazenamento em atmosfera controlada (AC com 1kPa de O2 e AC 5kPa de CO2 e AC com 1kPa de O2 e 5kPa de CO2 + 1-MCP no fim do armazenamento, após 2 meses de armazenamento a -0,5ºC mais 5 dias de exposição dos frutos a 10ºC e 3 dias a 20ºC. No armazenamento refrigerado, o 1-MCP, aplicado tanto no início do armazenamento como no final, proporcionou maior firmeza de polpa. Para os parâmetros: sólidos solúveis totais, podridão e escurecimento da película, não houve diferença estatística entre os tratamentos. Conclui-se que a aplicação de 1-MCP, tanto no início como no final do armazenamento mantém elevada a firmeza de polpa.The objective of this work was to evaluate the effect of 1-MCP applied at different period during the cold storage (CS and in controlled atmosphere (CA on the quality of 'Quioto'. Persimmon. The experimental design was completely randomized with four replications of 30 fruits and the tested treatments were: cold storage (CS, cold storage + 1-MCP (1000ppb in the beginning of the storage, cold storage + 1-MCP (1000ppb in the end of the storage period; storage in controlled atmosphere (CA with 1kPa of O2 and 5kPa of CO2 and 1kPa of O2 and 5kPa of CO2 + 1-MCP in the end of the storage, after 2 months of storage at -0.5ºC, plus 5 days at 10ºC and 3 days at 20ºC. In the cooled storage, the 1-MCP, applied as in the beginning of the storage as in the end of the storage, provided greater pulp firmness

  7. Pós colheita de bananas-maçã submetidas ao 1-MCP e armazenadas á temperatura ambiente Postharvest of 'apple' banana submetted to 1-MCP and storage in room temperature

    Directory of Open Access Journals (Sweden)

    Ana Carla Marque Pinheiro

    2006-04-01

    Full Text Available Bananas da cultivar Maçã foram adquiridas no estádio dois de coloração da casca (verde maturos e submetidas à ação de 1-MCP. O 1-MCP foi aplicado por 12 horas nas seguintes concentrações: 0 (controle, 50, 100, 150, 200 hL.L-1. Após aplicação, os frutos foram armazenados à temperatura ambiente (temperatura média 20ºC ± 1 e umidade relativa 80% ± 5 e avaliados à medida que atingiam os graus 3, 5 e 7 de coloração da casca. O tratamento com 1-MCP atrasou o início do amadurecimento de bananas-maçã armazenadas sob temperatura ambiente, baseado nas primeiras mudanças de coloração da casca. A aplicação de 1-MCP em bananas-maçã, ditou maiores valores de perda de massa e relação polpa/casca (nos graus 5 e 7 de coloração da casca. O 1-MCP, nas doses 100, 150 e 200 hL.L-1 de 1-MCP promoveu desverdecimento desuniforme e tonalidade avermelhada na casca. O tratamento 50 hL.L-1 de 1-MCP é o mais adequado, por promover a extensão da vida pós-colheita de bananas-maçã da cultivar armazenadas sob temperatura ambiente sem afetar a coloração da casca dos frutos, apresentando qualidade, baseando-se na cor da casca, firmeza, acidez titulável, pH e sólidos solúveis, semelhante ao controle.Mature green 'Apple' bananas were submitted to five concentrations of 1-MCP (0, 50, 100, 150 and 200 hL.L-1 for 12 hours. After treatment, the fruits were stored at room temperature (20ºC ± 1 and 80% ± 5 RH and analyzed at 3,5 and 7 color degree of peel. The treatment with 1-MCP delayed the start of the ripening based in the first changes of peel color. The treatment of 'Apple' bananas with 1-MCP promoted higher values of mass loss and pulp/peel ratio (5 and 7 degrees of color peel. The fruits treated with 100, 150 and 200 nL.L-1 of 1-MCP showed heterogeneous degreening and development of red color on the peel. 1-MCP at 50 nL.L-1 was the most appropriated treatment for promoting the extension of postharvest life of 'Apple' bananas stored

  8. A Comparative Analysis of Crime Guns

    Directory of Open Access Journals (Sweden)

    Megan E. Collins

    2017-10-01

    Full Text Available Information is limited on how firearms move from legal possession to illegal possession and use in criminal activities, largely because of data collection capacity and a lack of recent, exhaustive recovery data across jurisdictions. This article includes both an analysis of firearms trace data and prisoner interviews across multiple jurisdictions: New Orleans, Louisiana, Prince George’s County, Maryland, and Chicago, Illinois. Findings indicate that recoveries and trace successes vary across jurisdictions and by type of crime. Jurisdiction regulations were associated with the proportion of guns purchased in state and time to recovery but not with purchaser characteristics. Interviews from imprisoned offenders in two jurisdictions revealed the most common method of obtaining a crime gun was to steal it or buy it off the street.

  9. Instantaneous current and field structure of a gun-driven spheromak for two gun polarities

    International Nuclear Information System (INIS)

    Woodruff, S; Nagata, M

    2002-01-01

    The instantaneous plasma structure of the SPHEX spheromak is determined here by numerically processing data from insertable Rogowski and magnetic field probes. Data is presented and compared for two modes of gun operation: with the central electrode biased positively and negatively. It is found that while the mean-, or even instantaneous-, field structure would give the impression of a roughly axisymmetric spheromak, the instantaneous current structure does not. Hundred per cent variations in J measured at the magnetic axis can be explained by the rotation of a current filament that has a width equal to half of the radius of the flux-conserving first wall. In positive gun operation, current leaves the filament in the confinement region leading to high wall current there. In negative gun operation, wall current remains low as all injected current returns to the gun through the plasma. The plasma, in either instance, is strongly asymmetric. We discuss evidence for the existence of the current filament in other gun-driven spheromaks and coaxial plasma thrusters

  10. Gun possession among American youth: a discovery-based approach to understand gun violence.

    Science.gov (United States)

    Ruggles, Kelly V; Rajan, Sonali

    2014-01-01

    To apply discovery-based computational methods to nationally representative data from the Centers for Disease Control and Preventions' Youth Risk Behavior Surveillance System to better understand and visualize the behavioral factors associated with gun possession among adolescent youth. Our study uncovered the multidimensional nature of gun possession across nearly five million unique data points over a ten year period (2001-2011). Specifically, we automated odds ratio calculations for 55 risk behaviors to assemble a comprehensive table of associations for every behavior combination. Downstream analyses included the hierarchical clustering of risk behaviors based on their association "fingerprint" to 1) visualize and assess which behaviors frequently co-occur and 2) evaluate which risk behaviors are consistently found to be associated with gun possession. From these analyses, we identified more than 40 behavioral factors, including heroin use, using snuff on school property, having been injured in a fight, and having been a victim of sexual violence, that have and continue to be strongly associated with gun possession. Additionally, we identified six behavioral clusters based on association similarities: 1) physical activity and nutrition; 2) disordered eating, suicide and sexual violence; 3) weapon carrying and physical safety; 4) alcohol, marijuana and cigarette use; 5) drug use on school property and 6) overall drug use. Use of computational methodologies identified multiple risk behaviors, beyond more commonly discussed indicators of poor mental health, that are associated with gun possession among youth. Implications for prevention efforts and future interdisciplinary work applying computational methods to behavioral science data are described.

  11. Development of a Gun Wear Data Bank.

    Science.gov (United States)

    1979-11-01

    GO TO 3 INC.(j)zI 3 CONTINUE *4OLS=MF( ICCIr RETURN ENTRY SEL4 Jug C0 4 IIRKIN,IRPAX IJ=79 .AND. ISERS (1,1) 00 5 19219" IF (ZJ *EO. KODE (19)) GO TO 6... SEL4 will find data for each requested gun that also meets the requirements for selected records. 2. SUBROUTINE RBU will unpack velocity data for a

  12. Co-axial electrodes gun characteristics

    International Nuclear Information System (INIS)

    Masoud, M.M.; Soliman, H.M.

    1981-01-01

    A coaxial electrodes gun is constructed with inner electrode diameter of 3.2 cm; outer electrode diameter of 6.6 cm and length of 25 cm it is connected to a condenser bank which delivers 4 K joule stored energy. The maximum power of the discharge is equal to 4.5x10 4 K watt; for 5 KV charging voltage. The inductance showed two main peak values of 0.257μH and 0.27μH. Theoretical calculations using one-dimension-single fluid model is μ sed, which shows that the maximum acceleration is at 0.5 sec, and the gas breakdown takes place at the gun breech; at the start of the discharge, will leave the gun after 1.625μ sec, also the drift velocity, the force and the magnetic field are given. The measured results show quite reasonable agreement with the calculations for most of the results, and the position of the plasma sheath inside the gun slightly deviated from the theoretical calculations due to viscosity and wall interaction, as well as other parameters which did not be take into consideration. The plasma current density of the sheath has its maximum value at Z=18 cm, the plasma will leave the coaxial source after 1.5μ sec, from the start of the discharge, which conferms with the theoretical model. Resistance of the gas between the electrodes, changes with time according to the particle injected from this source, and the maximum efficiency of the installation for charging voltage 5kV and pressure 80μ Hg is at approx.=10μ sec and 20.5μ sec

  13. Cost Estimate for Gun Liner Emplacement

    Science.gov (United States)

    2011-08-01

    excellent material to resist wear and erosion in gun tubes, it is applied by an electrolytic process that involves hexavalent chromium, a known carcinogen...A recent Department of Defense memorandum has strongly urged that, wherever possible, processes involving hexavalent chromium be eliminated from...might be affordable.) Other refractory metals, such as the Stellite series, BioDur CCM* (a cobalt, chrome , molybdenum alloy), or niobium are less

  14. Magnetic guns with cylindrical permanent magnets

    Czech Academy of Sciences Publication Activity Database

    Vokoun, David; Beleggia, M.; Heller, Luděk

    2012-01-01

    Roč. 324, č. 9 (2012), s. 1715-1719 ISSN 0304-8853 R&D Projects: GA ČR(CZ) GAP107/11/0391; GA AV ČR IAA100100920 Institutional research plan: CEZ:AV0Z10100520 Keywords : permanent magnet * cylindrical magnet * Earnshaw's theorem * magnetic gun * magnetostatic interaction Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.826, year: 2012 http://www.sciencedirect.com/science/article/pii/S0304885311008997

  15. Gun Laws and Crime: An Empirical Assessment

    OpenAIRE

    Matti Viren

    2012-01-01

    This paper deals with the effect of gun laws on crime. Several empirical analyses are carried to investigate the relationship between five different crime rates and alternative law variables. The tests are based on cross-section data from US sates. Three different law variables are used in the analysis, together with a set of control variables for income, poverty, unemployment and ethnic background of the population. Empirical analysis does not lend support to the notion that crime laws would...

  16. 46 CFR 160.031-4 - Equipment for shoulder gun type line-throwing appliance.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 6 2010-10-01 2010-10-01 false Equipment for shoulder gun type line-throwing appliance... Appliance, Shoulder Gun Type (and Equipment) § 160.031-4 Equipment for shoulder gun type line-throwing... the gun. The line canister shall be secured by clamps or brackets below the barrel of the gun. (c) One...

  17. Gas Gun Studies of Interface Wear Effects

    Science.gov (United States)

    Jackson, Tyler; Kennedy, Greg; Thadhani, Naresh

    2011-06-01

    The characteristics of interface wear were studied by performing gas gun experiments at velocities up to 1 km/s. The approach involved developing coefficients of constitutive strength models for Al 6061 and OFHC-Cu, then using those to design die geometry for interface wear gas gun experiments. Taylor rod-on-anvil impact experiments were performed to obtain coefficients of the Johnson-Cook constitutive strength model by correlating experimentally obtained deformed states of impacted samples with those predicted using ANSYS AUTODYN hydrocode. Simulations were used with validated strength models to design geometry involving acceleration of Al rods through a copper concentric cylindrical angular extrusion die. Experiments were conducted using 7.62 mm and 80 mm diameter gas guns. Differences in the microstructure of the interface layer and microhardness values illustrate that stress-strain conditions produced during acceleration of Al through the hollow concentric copper die, at velocities less than 800 m/s, result in formation of a layer via solid state alloying due to severe plastic deformation, while higher velocities produce an interface layer consisting of melted and re-solidified aluminum.

  18. HMX based enhanced energy LOVA gun propellant

    Energy Technology Data Exchange (ETDEWEB)

    Sanghavi, R.R. [High Energy Materials Research Laboratory, Pune 411021 (India)]. E-mail: sanghavirr@yahoo.co.uk; Kamale, P.J. [High Energy Materials Research Laboratory, Pune 411021 (India); Shaikh, M.A.R. [High Energy Materials Research Laboratory, Pune 411021 (India); Shelar, S.D. [High Energy Materials Research Laboratory, Pune 411021 (India); Kumar, K. Sunil [High Energy Materials Research Laboratory, Pune 411021 (India); Singh, Amarjit [High Energy Materials Research Laboratory, Pune 411021 (India)

    2007-05-08

    Efforts to develop gun propellants with low vulnerability have recently been focused on enhancing the energy with a further improvement in its sensitivity characteristics. These propellants not only prevent catastrophic disasters due to unplanned initiation of currently used gun propellants (based on nitrate esters) but also realize enhanced energy levels to increase the muzzle velocity of the projectiles. Now, in order to replace nitroglycerine, which is highly sensitive to friction and impact, nitramines meet the requirements as they offer superior energy due to positive heat of formation, typical stoichiometry with higher decomposition temperatures and also owing to negative oxygen balance are less sensitive than stoichiometrically balanced NG. RDX has been widely reported for use in LOVA propellant. In this paper we have made an effort to present the work on scantily reported nitramine HMX based LOVA gun propellant while incorporating energetic plasticizer glycidyl azide polymer to enhance the energy level. HMX is known to be thermally stable at higher temperature than RDX and also proved to be less vulnerable to small scale shaped charge jet attack as its decomposition temperature is 270 deg. C. HMX also offers improved impulse due to its superior heat of formation (+17 kcal/mol) as compared to RDX (+14 kcal/mol). It has also been reported that a break point will not appear until 35,000 psi for propellant comprising of 5 {mu}m HMX. Since no work has been reported in open literature regarding replacement of RDX by HMX, the present studies were carried out.

  19. The HART I augmented electric gun facility

    International Nuclear Information System (INIS)

    Fikse, D.A.; Ciesar, J.A.; Wehrli, H.A.; Rimersma, H.; Docherty, E.F.; Pipich, C.W.

    1991-01-01

    This paper reports on an augmented electric gun system that has been commissioned. This system, called HART I (Hypervelocity Augmented Railgun Test), is built around a double augmented rail arrangement with a 1.27-cm square bore. It is powered by the SUVAC II 5.6-MJ distributed capacitor power supply. This arrangement allows operation in a simple, series augmented, or transaugmented gun system configuration. The objective of this facility is to perform materials research augmentation studies, and armature development in the 10-km/s regime. Armature masses of 2 to 4 g will be accelerated in a 4-m long barrel. Baseline bore materials will begin with conventional G9/GlidCop systems and then move into pyrolytic boron nitride/refractory materials. Hybrids, plasma, and ablation stabilized armature systems are planned. The gun system is instrumented with plasma and rail B probes for inbore velocity measurements. In addition, breech and muzzle voltages, currents, and external velocities are measured. The HART I system is currently performing hypervelocity experiments to verify the augmentation models

  20. Electromagnetic compression gun for hypervelocity projectile acceleration

    International Nuclear Information System (INIS)

    Woo, J.T.

    1987-01-01

    The rapid acceleration of projectiles to very high velocities has applications in many areas. The general requirements for an effective system is simplicity, reliability, compactness and good efficiency. The authors developed a concept by using electromagnetic forces to compressionally heat a plasma to high temperature and pressure to serve as the propellant for the acceleration of projectiles. The concept shares the simplicity of the light gas gun, but because of the high temperature of the propellant, is capable of significantly higher performance. Unlike the electrothermal gun approach to raise the propellant temperature by resistive heating, the electromagnetic concept is more efficient at higher temperatures. Operationally, the concept resembles a railgun in requiring a large pulsed current to drive the system. However, the current flow in this case is entirely external to the gun barrel and is axisymmetric. Therefore, many of the problems associated with railgun operations are avoided. Furthermore, because the current channel is external, there is also greater flexibility in the choice of load impedance to match to the power supply. The concept can also be generalized to a multi-stage regenerative system driven by a pulse forming network to resemble a coaxial accelerator

  1. Experimental Studies of Electrothermal Plasma Gun

    International Nuclear Information System (INIS)

    Diab, F.B.A.

    2013-01-01

    The aim of the present work is to study the capillary plasma discharge dynamics and characteristics. The capillary plasma device is a new technology for producing high density plasma after ablating the capillary wall using a pulsed electric power. An Electrothermal Plasma Gun (ETG) is composed of a capillary discharge tube made of Teflon operated with simple RLC circuit. The device called Electrothermal Gun (ETG) which is composed of 4 capacitors (70 μF, 10 kV, 1.28 μH) connected in parallel to a plasma source by means of one high power supply. The gun was operated in open air at discharge energies between 35 J - 3.5 kJ according to charging voltage. The work presented in this thesis covers the following items, 1- Measurements of the basic parameters and characterizations of the pretest results of the electrical circuits and capillary plasma discharge using Rogowski coil, voltage probe and Photomultiplier. 2- Material processing including (physics of the surface modifications, the morphology of the surface by using Scanning Electron Microscope (SEM) at different conditions, compositions of the materials by using X-ray Fluorescence (XRF), Micro hardness test and material particle deposition.

  2. Preparation of targets using electron gun systems

    International Nuclear Information System (INIS)

    Maier-Komor, P.

    1975-01-01

    Most targets of isotopes with very low vapor pressure can only be fabricated by vacuum deposition using an electron gun system or a heavy ion sputtering system. Heavy ion sputtering is a very new technique with many unsolved problems. Therefore it seems to be easier to work with an electron gun. Different commercially available electron guns, which are all designed for the high evaporation rates used in industry, are examined for their qualification in processing small amounts of material as used in fabrication of isotope targets. Electron backscattering and the associated efficiency of the electron beam power is strongly dependent on the atomic number Z of the evaporant and the incident angle of the electron beam on the surface of the evaporant. This dependence leads also to the undesired effects to the target layers from electrons and ions. Some precautions are necessary against the effects of the electrons and ions, which are formed in the plasma directly over the beam impact point. Beam power and beam density have to be chosen to get a constant evaporation rate and a low enough condensation rate in order not to overheat the target substrates. To evaporate some metals it may be helpful to pulse the electron beam

  3. Beam-Based Procedures for RF Guns

    CERN Document Server

    Krasilnikov, Mikhail; Grabosch, H J; Hartrott, Michael; Hui Han, Jang; Miltchev, Velizar; Oppelt, Anne; Petrosyan, Bagrat; Staykov, Lazar; Stephan, Frank

    2005-01-01

    A wide range of rf photo injector parameters has to be optimized in order to achieve an electron source performance as required for linac based high gain FELs. Some of the machine parameters can not be precisely controlled by direct measurements, whereas the tolerance on them is extremely tight. Therefore, this should be met with beam-based techniques. Procedures for beam-based alignment (BBA) of the laser on the photo cathode as well as solenoid alignment have been developed. They were applied at the Photo Injector Test facility at DESY Zeuthen (PITZ) and at the photo injector of the VUV-FEL at DESY Hamburg. A field balance of the accelerating mode in the 1 ½ cell gun cavity is one of the key beam dynamics issues of the rf gun. Since no direct field measurement in the half and full cell of the cavity is available for the PITZ gun, a beam-based technique to determine the field balance has been proposed. A beam-based rf phase monitoring procedure has been developed as well.

  4. Diagnostics Beamline for the SRF Gun Project

    CERN Document Server

    Kamps, T; Goldammer, K; Krämer, Dietrich; Kuske, P; Kuszynski, J; Lipka, D; Marhauser, F; Quast, T; Richter, R

    2005-01-01

    A superconducting rf photo electron injector (SRF gun) is currently under construction by a collaboration between BESSY, DESY, FZR and MBI. The project aims at the design and setup of an CW SRF gun including a diagnostics beamline for the ELBE FEL and to address R&D issues on low emittance injectors for future light sources such as the BESSY FEL. Of critical importance for the injector performance is the control of the electron beam parameters. For this reason a compact diagnostics beamline is under development serving a multitude of operation settings ranging from low-charge (77pC), low-emittance (1 pi mm mrad) mode to high-charge (2.5nC) operation of the gun. For these operation modes beam dynamics simulations are resulting in boundary conditions for the beam instrumentation. Proven and mature technology is projected wherever possible, for example for current and beam position monitoring. The layout of the beam profile and emittance measurement systems is described. For the bunch length, which varies be...

  5. THE IMPROVEMENT AND APPLICATION OF EI-GUN (ELECTRICAL INSEMINATION GUN FOR ARTIFICIAL INSEMINATION (AI USING GOAT FRESH SEMEN

    Directory of Open Access Journals (Sweden)

    Mirsa Ita Dewi

    2017-03-01

    Full Text Available Electrical Insemination Gun (EI-GUN was a tool for Artificial Insemination (AI using fresh semen with an electric control system. The research objective was to produced EI-GUN for AI using fresh semen on small ruminants (goat. The research was conducted from March to June 2015. The process of EI-GUN creation implemented in Design and Prototype Laboratory and Aero Modeling Research Laboratory at Engineering Faculty, University of Brawijaya (UB. Testing tools EI-GUN on goat was conducted in the Sumber Sekar Laboratory, Animal Husbandry Faculty, UB.  The methods of research were literature study, tool specification determination, designing EI-GUN, running test, semen evaluation passed EI-GUN and application on Goat. EI-GUN has seven important parts, which supports each other in this operating system. Those parts consist of stylet, servo, system controlled, insemination pump, connecting rod, battery, and holder. EI-GUN work system sucked the semen into insemination pump as much as 5 ml, and release the semen 0.25 ml appropriate standard of AI. It was applicable for 20 times AI. The results showed that the cell motility of spermatozoa ≥ 70% were still in ranging of Indonesian National Standard (SNI.   Keywords: artificial insemination, EI-GUN, fresh semen.

  6. Goods for Guns--the use of a gun buyback as an injury prevention/community education tool.

    Science.gov (United States)

    McGuire, Margaret; Manno, Mariann; Rook, Allison; Maranda, Louise; Renaud, Elizabeth; DeRoss, Anthony; Hirsh, Michael

    2011-11-01

    US children aged between 5 years and 14 years have a rate of gun-related homicide 17 times higher and a rate of gun-related suicide and unintentional firearm injury 10 times higher than other developed countries. Gun buyback programs have been criticized as ineffective interventions in decreasing violence. The Injury Free Coalition for Kids-Worcester (IFCK-W) Goods for Guns buyback is a multipronged approach to address these concerns and to reduce the number of firearms in the community. The IFCK-W buyback program is funded by corporate sponsors, grants, and individual donations. Citizens are instructed to transport guns, ammunition, and weapons safely to police headquarters on two Saturdays in December. Participants are guaranteed anonymity by the District Attorney's office and receive gift certificates for operable guns. Trained volunteers administer an anonymous survey to willing participants. Individuals who disclose having unsafely stored guns remaining at home receive educational counseling and trigger locks. Guns and ammunition are destroyed at a later time in a gun crushing ceremony. Since 2002, 1,861 guns (444 rifle/shotgun, 738 pistol/revolver, and 679 automatic/semiautomatic) have been collected at a cost of $99,250 (average, $53/gun). Seven hundred ten people have surrendered firearms, 534 surveys have been administered, and ≈ 75 trigger locks have been distributed per year. IFCK-W Goods for Guns is a relatively inexpensive injury prevention model program that removes unwanted firearms from homes, raises community awareness about gun safety, and provides high-risk individuals with trigger locks and educational counseling.

  7. Monocytes infiltrate the pancreas via the MCP-1/CCR2 pathway and differentiate into stellate cells.

    Directory of Open Access Journals (Sweden)

    Kazuko Ino

    Full Text Available Recent studies have shown that monocytes possess pluripotent plasticity. We previously reported that monocytes could differentiate into hepatic stellate cells. Although stellate cells are also present in the pancreas, their origin remains unclear. An accumulation of enhanced green fluorescent protein (EGFP(+CD45(- cells was observed in the pancreases and livers of chimeric mice, which were transplanted with a single hematopoietic stem cell isolated from EGFP-transgenic mice and treated with carbon tetrachloride (CCl4. Because the vast majority of EGFP(+CD45(- cells in the pancreas expressed stellate cell-associated antigens such as vimentin, desmin, glial fibrillary acidic protein, procollagen-I, and α-smooth muscle actin, they were characterized as pancreatic stellate cells (PaSCs. EGFP(+ PaSCs were also observed in CCl4-treated mice adoptively transferred with monocytes but not with other cell lineages isolated from EGFP-transgenic mice. The expression of monocyte chemoattractant protein-1 (MCP-1 and angiotensin II (Ang II increased in the pancreas of CCl4-treated mice and their respective receptors, C-C chemokine receptor 2 (CCR2 and Ang II type 1 receptor (AT1R, were expressed on Ly6C(high monocytes isolated from EGFP-transgenic mice. We examined the effect of an AT1R antagonist, irbesartan, which is also a CCR2 antagonist, on the migration of monocytes into the pancreas. Monocytes migrated toward MCP-1 but not Ang II in vitro. Irbesartan inhibited not only their in vitro chemotaxis but also in vivo migration of adoptively transferred monocytes from peripheral blood into the pancreas. Irbesartan treatment significantly reduced the numbers of EGFP(+F4/80(+CCR2(+ monocytic cells and EGFP(+ PaSCs in the pancreas of CCl4-treated chimeric mice receiving EGFP(+ bone marrow cells. A specific CCR2 antagonist RS504393 inhibited the occurrence of EGFP(+ PaSCs in injured mice. We propose that CCR2(+ monocytes migrate into the pancreas possibly via the

  8. Insulin resistance is associated with MCP1-mediated macrophage accumulation in skeletal muscle in mice and humans.

    Directory of Open Access Journals (Sweden)

    David Patsouris

    Full Text Available Inflammation is now recognized as a major factor contributing to type 2 diabetes (T2D. However, while the mechanisms and consequences associated with white adipose tissue inflammation are well described, very little is known concerning the situation in skeletal muscle. The aim of this study was to investigate, in vitro and in vivo, how skeletal muscle inflammation develops and how in turn it modulates local and systemic insulin sensitivity in different mice models of T2D and in humans, focusing on the role of the chemokine MCP1. Here, we found that skeletal muscle inflammation and macrophage markers are increased and associated with insulin resistance in mice models and humans. In addition, we demonstrated that intra-muscular TNFα expression is exclusively restricted to the population of intramuscular leukocytes and that the chemokine MCP1 was associated with skeletal muscle inflammatory markers in these models. Furthermore, we demonstrated that exposure of C2C12 myotubes to palmitate elevated the production of the chemokine MCP1 and that the muscle-specific overexpression of MCP1 in transgenic mice induced the local recruitment of macrophages and altered local insulin sensitivity. Overall our study demonstrates that skeletal muscle inflammation is clearly increased in the context of T2D in each one of the models we investigated, which is likely consecutive to the lipotoxic environment generated by peripheral insulin resistance, further increasing MCP1 expression in muscle. Consequently, our results suggest that MCP1-mediated skeletal muscle macrophages recruitment plays a role in the etiology of T2D.

  9. Gunning for accuracy: Company targets human error with 'foolproof' perforating gun

    Energy Technology Data Exchange (ETDEWEB)

    Ross, E.

    2002-12-01

    An innovative new design for a scalloped expandable perforating gun is described. The gun is manufactured in Edmonton by LRI Perforating Systems, and it aimed at reducing the chances of human error that can result in sub-optimal performance. A perforating gun is used to pierce the well's casing to allow hydrocarbons to flow into the wellbore. It consists of a carrier, a pipe with an eighth-inch thick wall that protects the explosives downhole, and an inner tube containing the explosives. The LRI system has a unique interlocking mechanism for the end plates, which are attached to either end of the thin-walled charge holder tube, in addition to other advantageous features, including a price advantage of 10 to 15 per cent. Marketing strategy is designed to interest wi reline companies that focus on vertical well applications. 1 photo.

  10. Spheromak experiment using separate guns for formation and sustainment

    International Nuclear Information System (INIS)

    Brown, M.R.; Martin, A.

    1996-01-01

    An experiment is described that incorporates the use of separate magnetized plasma guns for formation and sustainment of a spheromak. It is shown that energy coupling efficiency approaches unity if the gun and spheromak are of comparable size. A large gun should be able to operate at lower current and therefore lower voltage. In addition, it is expected that a gun matched to the size of the spheromak will cause less perturbation to the equilibrium. It is proposed to use a smaller gun for spheromak formation and a large, efficient gun for sustainment. The theoretical basis for the experiment is developed, and the details of the experiment are described. A prediction of the equilibrium magnetic flux surfaces using the EFIT code is presented. 28 refs., 3 figs., 1 tab

  11. Recent advances in high-brightness electron guns at AES

    International Nuclear Information System (INIS)

    Bluem, H.; Todd, A.M.M.; Cole, M.D.; Rathke, J.; Schultheiss, T.

    2003-01-01

    We describe a number of active Advanced Energy Systems projects pertaining to the development of advanced, high-brightness electron guns for various applications. These projects include a fully superconducting, CW RF gun, nearing test, that utilizes the niobium surface as the photocathode material. An integrated 100 mA, low emittance DC/SRF gun, ideal as an injector for ERL-type light sources and intended as the injector for a 100 kW FEL, is in late design stage. A parallel high-power, CW, normal-conducting L-band RF gun project has just begun. The early performance analysis for this gun also shows good promise as an injector for ERL-type light sources. Lastly, a fully axisymmetric RF gun, operating in X-band, is being studied as a source of extremely bright electron bunches

  12. Status and future prospects of SRF gun developments

    International Nuclear Information System (INIS)

    Teichert, Jochen

    2006-01-01

    While the concepts of DC and normal-conducting photo-injectors are well proofed, the SRF gun development still possesses a high risk. Challenges are the thermal and contaminant isolation needed between the cathode and superconducting cavity, the choice of the right photocathode and its life time, the difficulty of coupling high-average power into the gun, and beam excitation of higher order cavity modes. But in combination with SRF linacs, the SRF guns are the best solution for high current and CW operation. Thus, several R and D projects of SRF gun have been launched. The talk will give an overview of the history and progress of the SRF gun development. In more detail the technical concept, performance, and status of the Rossendorf superconducting RF gun project, a collaboration of BESSY, DESY, MBI and FZR, will be presented. (author)

  13. Plasma cytokines eotaxin, MIP-1α, MCP-4, and vascular endothelial growth factor in acute lower respiratory tract infection

    DEFF Research Database (Denmark)

    Relster, Mette Marie; Holm, Anette; Pedersen, Court

    2017-01-01

    ), monocyte chemoattractant protein 4 (MCP-4), and vascular endothelial growth factor (VEGF) in 40 patients hospitalized with acute lower respiratory tract infections (LRTI). The cytokines contribute to the pathogenesis of several inflammatory respiratory diseases, indicating a potential as markers for LRTI....... Patients were stratified according to etiology and severity of LRTI, based on baseline C-reactive protein and CURB-65 scores. Using a multiplex immunoassay of plasma, levels of eotaxin and MCP-4 were shown to increase from baseline until day 6 after admission to hospital. The four cytokines were unable...

  14. Acceleration of solid pellets using a plasma gun

    International Nuclear Information System (INIS)

    Buller, T.L.; Turnbull, R.J.; Kim, K.

    1979-01-01

    The use of solid pellets of hydrogen isotopes to refuel thermonuclear fusion reactors based on the tokamak configuration will require that the pellets be accelerated to high velocities. One possible method of acceleration is to interact a fast plasma from a plasma gun with the pellets. In this paper preliminary results are given on the acceleration of solid pellets with a plasma gun. The plasma-gun requirements for successful acceleration to high velocities are discussed

  15. Revised theory of Pierce-type electron guns

    International Nuclear Information System (INIS)

    Sar-El, H.Z.

    1982-01-01

    Attempts to date to obtain the shape of the beam forming electrodes of various Pierce-type electron guns are briefly discussed with emphasis on the many discrepansis in the results of previous works. A revised theory of Pierce-type electron guns is proposed. The shapes of the beam-forming electrodes for all known configurations of Pierce guns were computed on the basis of the proposed theory. (orig.)

  16. Evaluation of BICRON NE MCP DXT-RAD passive extremity dosemeter

    CERN Document Server

    Yuen, P S; Frketich, G; Rotunda, J

    1999-01-01

    Passive extremity dosemeters currently used in dosimetry communities worldwide have shortcomings. In general, an extremity dosemeter has too thick a detector element, and the dosemeter response is highly energy dependent for beta rays with energies ranging from 200 keV to 2 MeV. It often does not have dosemeter identification, causing problems in the chain of custody. It is often read manually, rendering reading/packing operations very labour intensive. As a result of collaboration between AECL and BICRON NE, a new extremity dosemeter, incorporating a highly sensitive LiF:Mg,Cu,P TLD and tentatively code named MCP DXT-RAD, was developed. It has been evaluated for radiological performance against an ISO draft standard for extremity dosemeters in twelve categories: homogeneity, detection threshold, beta ray energy response, beta angular response, photon energy response, photon angular response, reproducibility, stability under various climatic conditions, linearity, residue, self irradiation, and effect of ligh...

  17. Intermittent pneumatic leg compressions acutely upregulate VEGF and MCP-1 expression in skeletal muscle.

    Science.gov (United States)

    Roseguini, Bruno T; Mehmet Soylu, S; Whyte, Jeffrey J; Yang, H T; Newcomer, Sean; Laughlin, M Harold

    2010-06-01

    Application of intermittent pneumatic compressions (IPC) is an extensively used therapeutic strategy in vascular medicine, but the mechanisms by which this method works are unclear. We tested the hypothesis that acute application (150 min) of cyclic leg compressions in a rat model signals upregulation of angiogenic factors in skeletal muscle. To explore the impact of different pressures and frequency of compressions, we divided rats into four groups as follows: 120 mmHg (2 s inflation/2 s deflation), 200 mmHg (2 s/2 s), 120 mmHg (4 s/16 s), and control (no intervention). Blood flow and leg oxygenation (study 1) and the mRNA expression of angiogenic mediators in the rat tibialis anterior muscle (study 2) were assessed after a single session of IPC. In all three groups exposed to the intervention, a modest hyperemia (approximately 37% above baseline) between compressions and a slight, nonsignificant increase in leg oxygen consumption (approximately 30%) were observed during IPC. Compared with values in the control group, vascular endothelial growth factor (VEGF) and monocyte chemotactic protein-1 (MCP-1) mRNA increased significantly (P < 0.05) only in rats exposed to the higher frequency of compressions (2 s on/2 s off). Endothelial nitric oxide synthase, matrix metalloproteinase-2, and hypoxia-inducible factor-1alpha mRNA did not change significantly following the intervention. These findings show that IPC application augments the mRNA content of key angiogenic factors in skeletal muscle. Importantly, the magnitude of changes in mRNA expression appeared to be modulated by the frequency of compressions such that a higher frequency (15 cycles/min) evoked more robust changes in VEGF and MCP-1 compared with a lower frequency (3 cycles/min).

  18. Development of beam diagnostic devices for characterizing electron guns

    International Nuclear Information System (INIS)

    Bhattacharjee, D.; Tiwari, R.; Jayaprakash, D.; Mishra, R.L.; Sarukte, H.; Waghmare, A.; Thakur, N.; Dixit, K.P.

    2015-01-01

    The electron guns for the DC accelerators and RF Linacs are designed and developed at EBC/APPD/BARC, Kharghar. These electron guns need to be characterized for its design and performance. Two test benches were developed for characterizing the electron guns. Various beam diagnostic devices for measuring beam currents and beam sizes were developed. Conical faraday cup, segmented faraday cup, slit scanning bellows movement arrangement, multi-plate beam size measurement setup, multi- wire beam size measurement setup, Aluminum foil puncture assembly etc. were developed and used. The paper presents the in-house development of various beam diagnostics for characterizing electron guns and their use. (author)

  19. Geometry Optimization of DC/RF Photoelectron Gun

    CERN Document Server

    Chen Ping; Yu, David

    2005-01-01

    Pre-acceleration of photoelectrons in a pulsed, high voltage, short, dc gap and its subsequent injection into an rf gun is a promising method to improve electron beam emittance in rf accelerators. Simulation work has been performed in order to optimize the geometric shapes of a dc/rf gun and improve electron beam properties. Variations were made on cathode and anode shapes, dc gap distance, and inlet shape of the rf cavity. Simulations showed that significant improvement on the normalized emittance (< 1 mm-mrad), compared to a dc gun with flat cathode, could be obtained after the geometric shapes of the gun were optimized.

  20. Aeromagnetic Compensation for UAVs

    Science.gov (United States)

    Naprstek, T.; Lee, M. D.

    2017-12-01

    Aeromagnetic data is one of the most widely collected types of data in exploration geophysics. With the continuing prevalence of unmanned air vehicles (UAVs) in everyday life there is a strong push for aeromagnetic data collection using UAVs. However, apart from the many political and legal barriers to overcome in the development of UAVs as aeromagnetic data collection platforms, there are also significant scientific hurdles, primary of which is magnetic compensation. This is a well-established process in manned aircraft achieved through a combination of platform magnetic de-noising and compensation routines. However, not all of this protocol can be directly applied to UAVs due to fundamental differences in the platforms, most notably the decrease in scale causing magnetometers to be significantly closer to the avionics. As such, the methodology must be suitably adjusted. The National Research Council of Canada has collaborated with Aeromagnetic Solutions Incorporated to develop a standardized approach to de-noising and compensating UAVs, which is accomplished through a series of static and dynamic experiments. On the ground, small static tests are conducted on individual components to determine their magnetization. If they are highly magnetic, they are removed, demagnetized, or characterized such that they can be accounted for in the compensation. Dynamic tests can include measuring specific components as they are powered on and off to assess their potential effect on airborne data. The UAV is then flown, and a modified compensation routine is applied. These modifications include utilizing onboard autopilot current sensors as additional terms in the compensation algorithm. This process has been applied with success to fixed-wing and rotary-wing platforms, with both a standard manned-aircraft magnetometer, as well as a new atomic magnetometer, much smaller in scale.

  1. Coaxial plasma guns as injectors of high beta linear theta pinches

    International Nuclear Information System (INIS)

    Marshall, J.

    1975-01-01

    A brief review of research on coaxial plasma guns and their use is given. Some problems and possibilities of using this gun for beam injection experiments are pointed out. Some scaling laws for gun energy are described

  2. Brief use of a specific gun in a violent game does not affect attitudes towards that gun

    OpenAIRE

    Hilgard, Joseph; Engelhardt, Christopher R.; Bartholow, Bruce D.

    2016-01-01

    Although much attention has been paid to the question of whether violent video games increase aggressive behaviour, little attention has been paid to how such games might encourage antecedents of gun violence. In this study, we examined how product placement, the attractive in-game presentation of certain real-world firearm brands, might encourage gun ownership, a necessary antecedent of gun violence. We sought to study how the virtual portrayal of a real-world firearm (the Bushmaster AR-15) ...

  3. Changes in quality and biochemical parameters in 'Idared' apples during prolonged shelf life and 1-MCP treatment.

    Science.gov (United States)

    Bizjak, Jan; Slatnar, Ana; Stampar, Franci; Veberic, Robert

    2012-12-01

    In this study, changes in quality and various biochemical parameters of 'Idared' apples during prolonged shelf life period after ultra-low oxygen (ULO) storage were investigated. Additionally, the impact of the postharvest application of 1-methylcyclopropene (1-MCP) on different parameters was evaluated. After the harvest, apples were stored in the ULO storage for 6 months and then exposed to room temperature. Fruit firmness, peel color, and changes in sugars, organic acids and phenolics were monitored during the 3 weeks of shelf life. Malic acid, sugars and firmness decreased at room temperature. However, the color of the apples remained unchanged. The level of citric and ascorbic acid remained constant. Levels of phenolics in the peel increased significantly, whereas remained constant in the pulp of apples. 1-MCP treatment resulted in higher amounts of fructose and glucose, malic acid and greater firmness of apples. However, 1-MCP did not influence the phenolic content, ascorbic acid or color. The results obtained indicate that the content of different health-promoting compounds of apples does not change dramatically at room temperature. At the same time these results suggest that 1-MCP could be useful for maintaining certain quality and biochemical parameters and might extend the shelf life of apples.

  4. Action Alters Object Identification: Wielding a Gun Increases the Bias to See Guns

    Science.gov (United States)

    Witt, Jessica K.; Brockmole, James R.

    2012-01-01

    Stereotypes, expectations, and emotions influence an observer's ability to detect and categorize objects as guns. In light of recent work in action-perception interactions, however, there is another unexplored factor that may be critical: The action choices available to the perceiver. In five experiments, participants determined whether another…

  5. Perancangan Sistem Kontrol PID Untuk Pengendali Sumbu Elevasi Gun Pada Turret-Gun Kaliber 20 Milimeter

    Directory of Open Access Journals (Sweden)

    Dimas Kunto Ariwibowo

    2017-01-01

    Full Text Available Pertahanan negara pada hakikatnya adalah segala upaya pertahanan yang bersifat semesta yang didasarkan pada kesadaran atas hak dan kewajiban warga negara serta keyakinan pada kekuatan sendiri dengan tujuan untuk menjaga dan melindungi kedaulatan negara, keutuhan wilayah NKRI dan keselamatan segenap bangsa. Salah satu alat pendukung pertahanan yaitu senjata laras panjang, Turret-Gun.  Adapun langkah-langkah yang dilakukan dalam merancang pengendali PID Turret-Gun kaliber 20mm ini diawali dengan studi literatur serta studi lapangan mengenai mekanisme dan parameter-parameter yang terdapat pada Turret-Gun pada sumbu elevasi. Setelah itu dilakukan perancangan transmisi dan sistem kontrol Turret-Gun untuk dievaluasi grafik responnya yang akan digunakan sebagai acuan untuk merancang pengendali PID yang sesuai. Selanjutnya pengendali PID yang telah dirancang lalu disimulasikan, sehingga menghasilkan grafik respon yang sesuai dengan kriteria yang dibutuhkan. Hasil yang telah didapatkan dari penelitian ini adalah konstanta PID yang direkomendasikan untuk , , dan secara berturut-turut adalah sebesar 23061.024, 37820.07 dan 3515.4 yang menghasilkan transient response dengan nilai overshoot sebesar 19.9 % , steady state error sebesar 0 % serta settling time sebesar 0.935 detik. Hasil analisa kestabilan untuk sistem kontrol dengan konstanta PID tersebut menunjukkan bahwa sistem kontrol telah stabil, baik menggunakan metode Root Locus maupun metode Routh-Hurwitz.

  6. Enthalpy–entropy compensation

    Indian Academy of Sciences (India)

    Enthalpy–entropy compensation is the name given to the correlation sometimes observed between the estimates of the enthalpy and entropy of a reaction obtained from temperature-dependence data. Although the mainly artefactual nature of this correlation has been known for many years, the subject enjoys periodical ...

  7. Motion compensated digital tomosynthesis

    NARCIS (Netherlands)

    van der Reijden, Anneke; van Herk, Marcel; Sonke, Jan-Jakob

    2013-01-01

    Digital tomosynthesis (DTS) is a limited angle image reconstruction method for cone beam projections that offers patient surveillance capabilities during VMAT based SBRT delivery. Motion compensation (MC) has the potential to mitigate motion artifacts caused by respiratory motion, such as blur. The

  8. Teacher Compensation and Organization.

    Science.gov (United States)

    Kelley, Carolyn

    1997-01-01

    Examines changes in the conceptualization of schooling over time from an organizational perspective. Explores how compensation systems might be better designed to match alternative organizational designs, considering scientific management, effective schools, content-driven schooling, and high standards/high involvement schools as organizational…

  9. (statcom) in synchronous compensator

    African Journals Online (AJOL)

    eobe

    with fast response and low cost for stabilizing electricity grid power and voltage. ... The conventional and modified Newton-Raphson-based power flow equations .... The control of the reactive power exchange between .... because of its faster rate of convergence and accuracy ..... compensator, North American Power System.

  10. Reactive Power Compensating System.

    Energy Technology Data Exchange (ETDEWEB)

    Williams, Timothy J.; El-Sharkawi, Mohamed A.; Venkata, Subrahmanyam S.

    1985-01-04

    The circuit was designed for the specific application of wind-driven induction generators. It has great potential for application in any situation where a varying reactive power load is present, such as with induction motors or generators, or for transmission network compensation.

  11. The association between MCP-1, VEGF polymorphisms and their serum levels in patients with diabetic foot ulcer.

    Science.gov (United States)

    Li, Xiaolei

    2018-06-01

    The purpose of the present study was to investigate distribution of monocyte chemoattractant protein-1 (MCP-1) -2518A/G and vascular endothelial growth factor (VEGF) -634G/C polymorphisms in type 2 diabetes melitus patients (T2DM) presenting diabetic foot ulcer (DFU). Additionally, we evaluated the effects of these 2 polymorphisms on serum levels of MCP-1 and VEGF in the study population.Patients diagnosed with T2DM without or with DFU were recruited in the study. The distribution of MCP-1 -2518A/G and VEGF -634G/C polymorphisms was investigated by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Enzyme-linked immunosorbent assay (ELISA) was applied to detect the protein levels of MCP-1 and VEGF. The comparisons of protein levels in DFU patients were performed by student t test according to their genotypes.The frequencies of GG genotype and G allele of MCP-1 -2518A/G was increased in DFU patients, compared with T2DM patients (odds ratio [OR] = 2.60, 95% confidence interval [CI] = 1.23-5.50, P = .011 and OR = 1.72, 95% CI = 1.18-2.50, P = .005, respectively). Moreover, the increased frequency of GG was significantly associated with up-regulated MCP-1 level in DFU patients (P < .001). Analysis for VEGF -634G/C polymorphisms indicated that the prevalence of CC genotype and C allele of the polymorphisms was decreased in DFU patients, compared with T2DM patients (OR = 0.36, 95% CI = 0.17-0.77, P = .008 and OR = 0.63, 95% CI = 0.43-0.91, P = .015, respectively). DFU patients carrying CC genotype had a higher level of VEGF than those with other genotypes (P = .007).MCP-1 -2518A/G and VEGF -634G/C polymorphisms may involve in occurrence and progress of DFU through regulating transcription activity of the genes.

  12. Controlled atmosphere pO2 alters ripening dynamics of 1-MCP treated ‘d’Anjou’ pear (Pyrus communis L.) fruit

    Science.gov (United States)

    Ripening and development of physiological disorders and decay were assessed in ‘d’Anjou’ pear fruit following 1-methylcyclopropene (1-MCP) treatment and cold storage in air or controlled atmosphere (CA). Fruit were exposed after harvest to 0 or 12.6 µmol•L-1 1-MCP and then stored at 0.5 oC in air o...

  13. Laser-pulsed relativistic electron gun

    International Nuclear Information System (INIS)

    Sherman, N.K.

    1986-01-01

    A relativistic (β ≅ 0.8) electron gun with good emittance and subnanosecond pulse duration which can be synchronized to picosecond laser pulses is being developed at NRC for use in studies of particle acceleration by lasers. Bursts of electron pulses exceeding 280 keV in energy have been extracted into air form a laser-driven vacuum photodiode. Trains of 5 ps pulses of ultraviolet UV light illuminate a magnesium cathode. Photoelectrons emitted from the cathode are accelerated in a graded electrostatic potential set up by a 360 kV Marx-generator. The UV pulses are obtained by doubling the frequency of a 606 nm dye laser modelocked at 160 MHz. Electron energies were measured by residual range in an echelon of Al foils. Total charge per burst was measured by picoammeter. Time structure of the bursts has been examined with plastic scintillator and a fast photomultiplier. Tests on a low voltage photodiode achieved a current density of 180 A/cm/sup 2/ from an Mg cathode, with quantum efficiency of 2.4 x 10/sup -6/ electron per UV photon. The brevity and intensity of the laser pulses cause the electric charge collected per pulse to increase linearly with bias voltage rather than according to the Langmuir-Child law. Gun emittance is about 150 mm-msr and beam brightness is about 1A/cm/sup 2/-sr. Estimated duration of individual electron pulses of a burst is about 400 ps with instantaneous current of about 0.1 mA. Energy spread within one pulse is expected to be about 15%. This gun has the potential to be a useful source of relativistic electrons for laser acceleration studies

  14. Gun buyback programs: a venue to eliminate unwanted guns in the community.

    Science.gov (United States)

    Violano, Pina; Driscoll, Cassandra; Chaudhary, Neil K; Schuster, Kevin M; Davis, Kimberly A; Borer, Esther; Winters, Jane K; Hirsh, Michael P

    2014-09-01

    The United States has a high rate of death due to firearms, and gun buyback programs may mitigate these high death rates. Understanding the demographics, motivation, and geographic region of participants may improve program efficacy. Three Injury Free Coalition for Kids gun buyback programs, in collaboration with the local police, were studied: Phoenix, Arizona; Worcester, Massachusetts; and New Haven, Connecticut. Participants were defined as those who relinquished a firearm. A self-administered, anonymous, paper survey elicited information from participants regarding demographic data, formal training on the use of the firearm, how the firearm was acquired, potential child access, knowledge of others injured by a firearm, whether the firearm was stored unlocked, factors motivating the surrender of the firearm, and other factors. Survey results were entered into a composite database and analyzed for differences in location, race, sex, and other factors. Participants (n = 301) were predominantly male (73.5%), white (80.9%), and older than 55 years (59.0%). They lived an average of 19.0 miles from the event by zip codes and had an average median household income of $65,731. More than half (54.5%) did not purchase the firearm, acquiring it through inheritance, gift, or random find. Most (74.8%) had previous firearms training and were relinquishing for safety reasons (68.3%). Those relinquishing firearms for safety reasons were less likely to have purchased the firearm (odds ratio [OR], 2.46, p gun lock (OR, 0.15; p gun-wielding criminal acts were burglarized from the home of legal gun owners that had failed to secure them properly. The gun buyback program is solely one prong of a multipronged approach in reducing firearm-based interpersonal violence. Additional research is necessary to determine effective methods to target individuals who would have the greatest impact on gun violence if they relinquished their weapons. Through the forging of relationships and

  15. Characterisation of plasma in a rail gun

    Science.gov (United States)

    Ray, P. K.

    1986-01-01

    The mechanism of plasma and projectile acceleration in a DC rail gun is described from a microscopic point of view through the establishment of the Hall field. The plasma conductivity is shown to be a tensor, indicating that there is a small component of current parallel to the direction of acceleration. The plasma characteristics are evaluated in the experiment of Bauer et. al., as a function of plasma mass through a simple fluid mechanical analysis of the plasma. By equating the energy dissipatated in the plasma with the radiation heat loss, the properties of the plasma are determined.

  16. Gas powered fluid gun with recoil mitigation

    Science.gov (United States)

    Grubelich, Mark C; Yonas, Gerold

    2013-11-12

    A gas powered fluid gun for propelling a stream or slug of a fluid at high velocity toward a target. Recoil mitigation is provided that reduces or eliminates the associated recoil forces, with minimal or no backwash. By launching a quantity of water in the opposite direction, net momentum forces are reduced or eliminated. Examples of recoil mitigation devices include a cone for making a conical fluid sheet, a device forming multiple impinging streams of fluid, a cavitating venturi, one or more spinning vanes, or an annular tangential entry/exit.

  17. Electron gun simulation for 95 GHz gyrotron

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Udaybir; Kumar, Nitin; Sinha, A.K., E-mail: uday.ceeri@gmail.com, E-mail: aksinha@ceeri.ernet.in [Gyrotron Laboratory, Microwave Tube Area, Central Electronics Engineering Research Institute, Pilani (India); Purohit, L.P. [Department of Physics, Gurukul Kangri Vishwavidyalaya, Haridwar (India)

    2011-07-01

    A triode type Magnetron Injection Gun (MIG) for a 2 MW, 95 GHz Gyrotron has been designed by using commercially available code EGUN and another in-house developed code MIGANS. The operating mode of the gyrotron is TE{sub 24.8} and it is operated in the fundamental harmonic. The operating voltages of the modulating anode and the accelerating anode are 61 kV and 85 kV respectively. The parametric dependences of modulating anode voltage and cathode magnetic field on the beam quality have also been studied. (author)

  18. Electron gun simulation for 95 GHz gyrotron

    International Nuclear Information System (INIS)

    Singh, Udaybir; Kumar, Nitin; Sinha, A.K.; Purohit, L.P.

    2011-01-01

    A triode type Magnetron Injection Gun (MIG) for a 2 MW, 95 GHz Gyrotron has been designed by using commercially available code EGUN and another in-house developed code MIGANS. The operating mode of the gyrotron is TE 24.8 and it is operated in the fundamental harmonic. The operating voltages of the modulating anode and the accelerating anode are 61 kV and 85 kV respectively. The parametric dependences of modulating anode voltage and cathode magnetic field on the beam quality have also been studied. (author)

  19. Multiphysics modeling of a rail gun launcher

    Directory of Open Access Journals (Sweden)

    Y W Kwon

    2016-03-01

    Full Text Available A finite element based multiphysics modeling was conducted for a rail gunlauncher to predict the exit velocity of the launch object, and temperaturedistribution. For this modeling, electromagnetic field analysis, heat transferanalysis, thermal stress analysis, and dynamic analysis were conducted fora system consisting of two parallel rails and a moving armature. In particular,an emphasis was given to model the contact interface between rails andthe armature. A contact theory was used to estimate the electric as well asthermal conductivities at the interface. Using the developed model, aparametric study was conducted to understand effects of variousparameters on the exit velocity as well as the temperature distribution in therail gun launcher.

  20. Smart gun technology requirements preliminary report

    Energy Technology Data Exchange (ETDEWEB)

    Weiss, D.R.; Brandt, D.J.; Tweet, K.D.

    1995-05-01

    Goal of the Smart Gun Technology project is to eliminate the capability of an unauthorized user from firing a law enforcement officer`s firearm by implementing user-recognizing-and-authorizing surety technologies. This project is funded by the National Institute of Justice. This document reports the projects first objective: to find and document the requirements for a user-recognizing-and-authorizing firearm technology that law enforcement officers will value. This report details the problem of firearm takeaways in law enforcement, the methodology used to develop the law enforcement officers` requirements, and the requirements themselves.

  1. Voltage-pulse generator for electron gun

    International Nuclear Information System (INIS)

    Korenev, S.A.; Enchevich, I.B.; Mikhov, M.K.

    1987-01-01

    A voltage-pulse generator with combined capacitive and inductive storage devices of an electron gun is described. The current interrupter is a hydrogen thyratron (TGI1-100/8, TGI1-500/16, or TGI1-1000/25) installed in a short magnetic lens. The current interruption time of the thyratrons is 100-300 nsec. When the capacitive storage device is charged to 1 kV, a voltage pulse with an amplitude of 25 kV is obtained at the load

  2. Magnetic guns with cylindrical permanent magnets

    DEFF Research Database (Denmark)

    Vokoun, David; Beleggia, Marco; Heller, Luděk

    2012-01-01

    The motion of a cylindrical permanent magnet (projectile) inside a tubular permanent magnet, with both magnets magnetized axially, illustrates nicely the physical principles behind the operation of magnetic guns. The force acting upon the projectile is expressed semi-analytically as derivative...... of the magnetostatic interaction energy. For comparison, the forces involved are also calculated numerically using finite elements methods. Based on the conservation of the magnetostatic and kinetic energies, the exit and asymptotic velocities are determined. The derived formulas can be used to optimize the generated...... forces and motion of the inner cylindrical magnet....

  3. Electron gun simulation with CST PARTICLE STUDIO

    International Nuclear Information System (INIS)

    Spachmann, Holger; Becker, Ulrich

    2006-01-01

    This paper introduces CST PARTICLE STUDIO TM , a specialist tool for the fast and accurate design and analysis of 3D electron guns. The new software is based on the multi-purpose electromagnetic solvers of the CST STUDIO family and incorporates their powerful modelling capabilities as well as successful algorithms of the MAFIA-TS simulators. The underlying theory of the PBA based field solvers and the used tracking technique is presented and some examples of application demonstrate the current status of the software

  4. Testing a GaAs cathode in SRF gun

    International Nuclear Information System (INIS)

    Wang, E.; Kewisch, J.; Ben-Zvi, I.; Burrill, A.; Rao, T.; Wu, Q.; Holmes, D.

    2011-01-01

    RF electron guns with a strained superlattice GaAs cathode are expected to generate polarized electron beams of higher brightness and lower emittance than do DC guns, due to their higher field gradient at the cathode's surface and lower cathode temperature. We plan to install a bulk GaAs:Cs in a SRF gun to evaluate the performance of both the gun and the cathode in this environment. The status of this project is: In our 1.3 GHz 1/2 cell SRF gun, the vacuum can be maintained at nearly 10 -12 Torr because of cryo-pumping at 2K. With conventional activation of bulk GaAs, we obtained a QE of 10% at 532 nm, with lifetime of more than 3 days in the preparation chamber and have shown that it can survive in transport from the preparation chamber to the gun. The beam line has been assembled and we are exploring the best conditions for baking the cathode under vacuum. We report here the progress of our test of the GaAs cathode in the SRF gun. Future particle accelerators, such as eRHIC and the ILC require high-brightness, high-current polarized electrons. Strained superlattice GaAs:Cs has been shown to be an efficient cathode for producing polarized electrons. Activation of GaAs with Cs,O(F) lowers the electron affinity and makes it energetically possible for all the electrons, excited into the conduction band that drift or diffuse to the emission surface, to escape into the vacuum. Presently, all operating polarized electron sources, such as the CEBAF, are DC guns. In these devices, the excellent ultra-high vacuum extends the lifetime of the cathode. However, the low field gradient on the photocathode's emission surface of the DC guns limits the beam quality. The higher accelerating gradients, possible in the RF guns, generate a far better beam. Until recently, most RF guns operated at room temperature, limiting the vacuum to ∼10 -9 Torr. This destroys the GaAs's NEA surface. The SRF guns combine the excellent vacuum conditions of DC guns and the high accelerating

  5. Gun possession among American youth: a discovery-based approach to understand gun violence.

    Directory of Open Access Journals (Sweden)

    Kelly V Ruggles

    Full Text Available OBJECTIVE: To apply discovery-based computational methods to nationally representative data from the Centers for Disease Control and Preventions' Youth Risk Behavior Surveillance System to better understand and visualize the behavioral factors associated with gun possession among adolescent youth. RESULTS: Our study uncovered the multidimensional nature of gun possession across nearly five million unique data points over a ten year period (2001-2011. Specifically, we automated odds ratio calculations for 55 risk behaviors to assemble a comprehensive table of associations for every behavior combination. Downstream analyses included the hierarchical clustering of risk behaviors based on their association "fingerprint" to 1 visualize and assess which behaviors frequently co-occur and 2 evaluate which risk behaviors are consistently found to be associated with gun possession. From these analyses, we identified more than 40 behavioral factors, including heroin use, using snuff on school property, having been injured in a fight, and having been a victim of sexual violence, that have and continue to be strongly associated with gun possession. Additionally, we identified six behavioral clusters based on association similarities: 1 physical activity and nutrition; 2 disordered eating, suicide and sexual violence; 3 weapon carrying and physical safety; 4 alcohol, marijuana and cigarette use; 5 drug use on school property and 6 overall drug use. CONCLUSIONS: Use of computational methodologies identified multiple risk behaviors, beyond more commonly discussed indicators of poor mental health, that are associated with gun possession among youth. Implications for prevention efforts and future interdisciplinary work applying computational methods to behavioral science data are described.

  6. Combination of IL-6, IL-10, and MCP-1 with traditional serum tumor markers in lung cancer diagnosis and prognosis.

    Science.gov (United States)

    Pan, Y W; Zhou, Z G; Wang, M; Dong, J Q; Du, K P; Li, S; Liu, Y L; Lv, P J; Gao, J B

    2016-11-03

    Early detection and treatment is critically important for lung cancer patients. Inflammatory mediators such as IL-6, IL-10, and MCP-1 participate in lung cancer regulation. CEA, CA125, and ProGRP are commonly used serum tumor markers for lung cancer. In this study, we assessed the sensitivity and specificity of CEA, CA125, and ProGRP when used in combination with IL-6, IL-10, and MCP in lung cancer diagnosis. Serum from three different groups (healthy controls, individuals with high risk for lung cancer, and lung cancer patients) was collected. Electrochemiluminescence was used to detect expressions of CEA, CA125, and ProGRP; ELISA was used to examine serum levels of IL-6, IL-10, and MCP-1. Specificity and sensitivity of single as well as combination markers in lung cancer diagnosis were determined. Results indicated that CEA, CA125, ProGRP, and MCP-1 were significantly up-regulated in lung cancer patients as compared to those in controls and high risk individuals. Higher IL-6 and IL-10 levels were observed in both lung cancer patients and high-risk individuals as compared to those in controls. Highest sensitivity (95.2%) in cancer diagnosis was achieved when all six markers were used. This was followed by a combination of IL-6, IL-10, CEA, CA125, and ProGRP (92.6%). The most sensitive (88.6%). Four-marker combination was composed of IL-6, CEA, CA125, and ProGRP. As the combined usage of CEA, CA125, ProGRP, IL-6, IL-10, and MCP-1 significantly improved sensitivity of lung cancer detection; this biomarker arrangement may be beneficial for early diagnosis, treatment, and prognosis of lung cancer.

  7. Effect of DPA and 1-MCP on chemical compounds related to superficial scald of Granny Smith apples

    Energy Technology Data Exchange (ETDEWEB)

    Moggia, C.; Moya-Leon, M. A.; Pereira, M.; Yuri, J. A.; Lobos, G. A.

    2010-07-01

    Research was carried out to study the mode of action of diphenylamine (DPA) and 1-methylcyclopropene (1-MCP), on control of superficial scald of Granny Smith apples (Malus domestica Borkh.), and its relation with chemical compounds. Fruit was harvested from a commercial orchard in Chile, 182 and 189 days after full bloom and received the following treatments: DPA (2,000 ppm); 1-MCP (1.2 ppm) and control (no treatment). All fruit was stored for 4 or 6 months at 0 degree centigrade. A completely randomized factorial design was used (2 harvest dates by 3 post harvest treatments). Monthly measurements were made on maturity indices, ethylene production rate (EPR), scald related compounds [a-farnesene (AF), conjugated trienes (CT), total anti-oxidants (AO)], and cell membrane stability. Following 4 and 6 months of storage, plus 7 days at 20 degree centigrade, scald was evaluated. After 6 months, DPA-treated fruit, from both harvests, showed similar firmness, EPR and AO, compared to the control. However, AF and CT were lower, and cell membrane stability higher. Conversely, 1-MCP-treated fruit showed a noticeable EPR suppression and AF inhibition, along with higher firmness, lower CT and AO, compared to the control and DPA. Furthermore, cell membrane stability was superior to that of the control and similar to that of the DPA. Treated fruit (DPA and 1-MCP) showed an important reduction in scald compared to the control. The effect of 1-MCP on the investigated compounds and the reduction in scald, confirms that ethylene plays a major role on its development. (Author) 50 refs.

  8. Research and design of electron gun of electrocurtain

    International Nuclear Information System (INIS)

    Chen Pengfei; Zhang Mingchao; Li Xinmin; Wang Yuhong

    1998-01-01

    The characteristics of the electron beam current transport in the electron gun of the electrocurtain accelerator were studied and the origin of the influence on longitudinal uniformity of beam current was analysed. The deflection of the cathode is considered under the boundary condition of perfect constraint. Then a newly designed electron gun is introduced with longitudinal uniformity of current within +-10%

  9. The breakdown phase in a coaxial plasma gun

    International Nuclear Information System (INIS)

    Donges, A.; Herziger, G.; Krompholz, H.; Ruehl, F.; Schoenbach, K.

    1980-01-01

    The electrical breakdown in a coaxial plasma gun was investigated by means of optical and electrical measurements. The optimum start and operation conditions of the gun turned out to be strongly dependent on material and length of the cylindrical insulator. (orig.)

  10. Preventing Clogging In A Vacuum Plasma Spray Gun

    Science.gov (United States)

    Krotz, Phillip D.; Daniel, Ronald L., Jr.; Davis, William M.

    1994-01-01

    Modification of powder-injection ports enables lengthy, high-temperature deposition operations. Graphite inserts prevent clogging of ports through which copper powder injected into vacuum plasma spray (VPS) gun. Graphite liners eliminate need to spend production time refurbishing VPS gun, reducing cost of production and increasing productivity. Concept also applied to other material systems used for net-shape fabrication via VPS.

  11. Study and realization of an electron gun at low energy

    International Nuclear Information System (INIS)

    Camus, P.

    1977-01-01

    This work presents the theoretical concepts and experimental design of an electron gun. This gun is working in the weak energy range and the focus position is independant of electron energy measurements and analysis methods of the electron beam are described [fr

  12. The gun control system of the IFUSP microtron

    International Nuclear Information System (INIS)

    Malafronte, A.A.; Takahashi, J.; Bonini, A.L.; Martins, M.N.

    1997-01-01

    A thermionic gun control system has been developed for the IFUSP microtron. The control system, which is composed of a dedicated microcomputer, A/D converter, grid pulser, filament and grid power supplies, is kept at a high voltage potential. The gun parameters are handled through a PC computer at ground potential via fiber-optic link. (orig.)

  13. A flow cryostat for cooling of eight independent pipe guns

    DEFF Research Database (Denmark)

    Sørensen, H.; Hansen, J.E.; Sass, B.

    1991-01-01

    A flow cryostat allowing independent cooling of eight pipe guns in a multishot deuterium pellet injector is described. The pipe guns are placed symmetrically around the flow cryostat and with a liquid helium consumption of 4-5 l/h the cooling is sufficient for simultaneous formation of eight...

  14. Changing of ballistic parameters from aged gun propellants

    NARCIS (Netherlands)

    Klerk, W.P.C. de; Driel, C.A. van

    2003-01-01

    The various properties of an SB and a DB gun propellant were investigated before and after artificial ageing. It was found that the decrease of nitrocellulose (NC) molecular weight, due to ageing of gun propellants, leads to a decrease of the mechanical integrity of the propellant grains. The effect

  15. Unusual blunt force wound produced by a gun muzzle.

    Science.gov (United States)

    Hanzlick, R; Zaki, S A

    1986-09-01

    Most blunt force injuries produced by guns are associated with gun butts, and patterned, muzzle/sight impressions are usually produced by discharging firearms. An unusual and distinct forehead laceration produced by a blow with the muzzle end of a .32 caliber revolver is presented.

  16. Normative Considerations in the Aftermath of Gun Violence in Schools

    Science.gov (United States)

    Gereluk, Dianne T.; Donlevy, J. Kent; Thompson, Merlin B.

    2015-01-01

    Gun violence in American and Canadian schools is an ongoing tragedy that goes substantially beyond its roots in the interlocking emotional and behavioral issues of mental health and bullying. In light of the need for effective policy development, Dianne T. Gereluk, J. Kent Donlevy, and Merlin B. Thompson examine gun violence in schools from…

  17. Grip-pattern recognition: Applied to a smart gun

    NARCIS (Netherlands)

    Shang, X.

    2008-01-01

    In our work the verification performance of a biometric recognition system based on grip patterns, as part of a smart gun for use by the police ocers, has been investigated. The biometric features are extracted from a two-dimensional pattern of the pressure, exerted on the grip of a gun by the hand

  18. Everyday Engineering: What Makes a Squirt Gun Squirt?

    Science.gov (United States)

    Moyer, Richard; Everett, Susan

    2009-01-01

    You may not think of engineering and squirt guns in the same sentence. However, like many examples of engineering design, the squirt gun pump mechanism is uncomplicated, yet elegant, and very inexpensive to manufacture. The design is widely used because of its simplicity and low cost. With only a few moving parts, it is able to deliver a stream of…

  19. Taking Aim at Gun Violence: Rebuilding Community Education & Employment Pathways

    Science.gov (United States)

    Bryant, Rhonda

    2013-01-01

    In January 2013, President Obama released a plan for protecting children and communities by reducing gun violence. This plan has generated serious debate from both sides of the issue. The ensuing conversations about how to solve the issue of gun violence have been volatile. The President's plan includes reforms to close loopholes on background…

  20. Guns and Fear: A One-Way Street?

    Science.gov (United States)

    Hauser, Will; Kleck, Gary

    2013-01-01

    Surveys show that more than one half of gun owners report owning their firearm for self-protection. Although research has examined the effect of fear of crime on gun ownership, the issue of reciprocity and temporal order has been largely ignored. Furthermore, the effect of firearm acquisition and relinquishment on fear has not been evaluated…

  1. Technological guns which form the profiled electron beans

    International Nuclear Information System (INIS)

    Mel'nik, V.I.

    1998-01-01

    Electron guns with high-voltage glow discharge are developed which form disc - and tubule-like,hollow conic and linear electron beams,as well as devices and systems for control of gun parameter and technological processes in low and intermediate vacuum

  2. Characteristics of typical Pierce guns for PPM focused TWTs

    International Nuclear Information System (INIS)

    Harper, R.; Puri, M.P.

    1989-01-01

    The performance of typical moderate perveance Pierce type electron guns which are used in periodic permanent magnet focused traveling wave tubes are described with regard to adaptation for use in electron beam ion sources. The results of detailed electron trajectory computations for one particular gun design are presented

  3. Emittance growth in laser-driven RF electron guns

    International Nuclear Information System (INIS)

    Kim, K.J.

    1989-01-01

    A simple analysis for the evolution of the electron-beam phase space distribution in laser-driven rf guns is presented. In particular, formulas are derived for the transverse and longitudinal emittances at the exit of the gun. The results are compared and found to agree well with those from simulation. (Author). 9 refs.; 4 figs

  4. Gun Access and Safety Practices among Older Adults

    Directory of Open Access Journals (Sweden)

    Hillary D. Lum

    2016-01-01

    Full Text Available Background. Given high rates of gun ownership among older adults, geriatric providers can assess firearm safety practices using a “5 Ls” approach: Locked; Loaded; Little children; feeling Low; and Learned owner. This study describes gun access and the “5 Ls” among US older adults. Methods. Data on the “5 Ls” from the Second Injury Control and Risk Survey (ICARIS-2, a national telephone survey conducted by the Centers for Disease Control and Prevention, were analyzed. Weighted variables were used to generate national estimates regarding prevalence of gun ownership and associated gun safety among older adults (≥55 years. Results. Of 2939 older adults, 39% (95% CI 37%–42% reported ≥1 gun stored at home. Among those with guns at home, 21% (95% CI 18–24% stored guns loaded and unlocked; 9.2% (95% CI 6.6–12% had ≥1 child in household; 5.1% (95% CI 3.5–6.8% reported past-year suicidal ideation and 3.6% (95% CI 2.1–5.2% reported history of a suicide attempt; and 55% (95% CI 51–59% stated that ≥1 adult had attended firearm safety workshop. Conclusion. Some older adults may be at elevated risk of firearm injury because of storage practices, suicidal thoughts, or limited safety training. Future work should assess effective approaches to reduce the risk of gun-related injuries among older adults.

  5. Gun Possession among Massachusetts Batterer Intervention Program Enrollees

    Science.gov (United States)

    Rothman, Emily F.; Johnson, Renee M.; Hemenway, David

    2006-01-01

    Batterers with access to firearms present a serious lethal threat to their partners. The purpose of this exploratory study is to estimate the prevalence of and risk markers for gun possession among Massachusetts men enrolled in batterer intervention programs. The authors found that 1.8% of the men reported having a gun in or around their home.…

  6. Processing of Niobium-Lined M240 Machine Gun Barrels

    Science.gov (United States)

    2014-11-01

    Fig. 5 Finished niobium-lined M240 machine gun barrel with flash suppressor attached ..........11 Fig. 6 End of barrel 1 showing small amount of...the finished barrel is shown in Fig. 5. 11 Fig. 5 Finished niobium-lined M240 machine gun barrel with flash suppressor attached Firing tests

  7. A 3 GHz photoelectron gun for high beam intensity

    CERN Document Server

    Bossart, Rudolf; Dehler, M; Godot, J C

    1996-01-01

    For the Compact Linear Collider Test Facility (CTF) at CERN a new rf gun with a laser driven photocathode is under construction. The new rf gun will replace the present 11/2 cell gun and will consist of 21/2 cells accelerating the beam to a momentum of 7.0 MeV/c with an electric field strength of 100 MV/m. The strong space-charge forces at low beam energy caused by the high charge density of the electron bunches are contained by radial and longitudinal rf focusing in the gun. The rf gun under construction has been optimized by MAFIA beam simulations for an injector assembly comprising a second accelerating rf structure and an intermediate solenoid magnet correcting the beam divergence of the 21/2 cell gun. The beam loading of the rf gun, by a train of 48 bunches with 21 nC charge each, causes a strong energy decay accompanied by an increase of the flight time for the bunches with lower energy. These effects can be corrected by slightly shifting the acceleration frequency of the gun. The experimental results...

  8. Utility of indices of gun availability in the community.

    Science.gov (United States)

    Shenassa, Edmond D; Daskalakis, Constantine; Buka, Stephen L

    2006-01-01

    To estimate the degree to which the proportion of homicides and suicides committed with a gun is associated with reported availability of firearms across Chicago neighbourhoods. Data were collected as part of the Project on Human Development in Chicago Neighborhoods (PHDCN), a combined neighbourhood and individual level study of the city of Chicago. The study used data from 837 PHDCN participants between the ages of 17 and 22, residing in 170 different neighbourhoods. Gun availability was measured via participant reports on whether they had carried a gun and whether they perceived gun access to be easy in their community. Data on suicides and homicides were obtained from the Chicago Department of Health. A 10% change in the proportion of homicides committed by a gun in a neighbourhood was associated with a 20% increase in both the odds of reported gun access and reported gun carrying (p=0.002 and 0.048, respectively). The proportion of firearm related suicides was not associated with either of those self reported measures. The proportion of firearm related homicides, but not the proportion of firearm related suicides, is a useful predictor of gun availability across small areas such as neighbourhoods.

  9. Unsteady flow analysis of combustion processes in a Davis gun

    Energy Technology Data Exchange (ETDEWEB)

    Cho, H.-C.; Shin, H.D. [Korea Advanced Inst. of Science and Technology, Mechanical Engineering Dept., Taejon (Korea, Republic of); Yoon, J.-K. [Hansung Univ., School of Industrial and System Engineering, Seoul (Korea, Republic of)

    1999-09-01

    The Davis gun, a type of recoilless gun, had the advantages of requiring less rear area and less powder than a conventional recoilless gun. The unsteady pressure and flow fields of a Davis gun were numerically simulated by using a two-phase fluid dynamic model. Numerical simulation results were compared with experimental values to evaluate the feasibility of the interior ballistic model. The interior ballistics in a Davis gun with a simple countermass were predicted with the computational model. It was shown that the pressure-time curves matched well between experimental data and numerical analysis except in the vicinity of the peak pressure and steep pressure gradient. The predicted muzzle velocity of projectile and countermass was closely similar to the experimental one. In this study, large pressure waves were not observed since the initial porosity was relatively high ({phi}{sub 0}0.867) and the charge was ignited at the centre of the granular bed. (Author)

  10. Therminoic gun control system for the CEBAF injector

    International Nuclear Information System (INIS)

    Pico, R.; Diamond, B.; Fugitt, J.; Bork, R.

    1989-01-01

    The injector for the CEBAF accelerator must produce a high-quality electron beam to meet the overall accelerator specifications. A Hermosa electron gun with a 2 mm-diameter cathode and a control aperture has been chosen as the electron source. This must be controlled over a wide range of operating conditions to meet the beam specifications and to provide flexibility for accelerator commissioning. The gun is controlled using Computer Automated Measurement and Control (CAMAC IEEE-583) technology. The system employs the CAMAC-based control architecture developed at CEBAF. The control system has been tested, and early operating data on the electron gun and the injector beam transport system has been obtained. This system also allows gun parameters to be stored at the operator location, without paralyzing operation. This paper describes the use of this computer system in the control of the CEBAF electron gun. 2 refs., 6 figs., 1 tab

  11. Particle transport and gas feed during gun injection

    International Nuclear Information System (INIS)

    Fowler, T K.

    1999-01-01

    It is shown that ion and neutral transport during gun injection tends to equalize the density in the spheromak to that in the open-line current channel. Since a gun operating at or near the ion saturation current requires a minimum density, because of transport these gun requirements also determine a minimum density in the spheromak that increases as the field increases. Hence attaining high fields by gun injection sets lower limits on the density, which in turn limits the temperature of the plasma and increases its ohmic resistance. Estimates of these effects are given using 0-D models calibrated to CTX, as guidance to 2-D UEDGE calculations in progress. For gun power levels in SSPX and the Pulsed Spheromak reactor, we find that buildup persists to the highest field levels of interest

  12. An rf modulated electron gun pulser for linacs

    International Nuclear Information System (INIS)

    Legg, R.; Hartline, R.

    1991-01-01

    Present linac injector designs often make use of sub-harmonic prebuncher cavities to properly bunch the electron beam before injection into a buncher and subsequent accelerating cavities. This paper proposes an rf modulated thermionic gun which would allow the sub-harmonic buncher to be eliminated from the injector. The performance parameters for the proposed gun are 120 kV operating voltage, macropulse duration-single pulse mode 2 nsec, multiple pulse mode 100 nsec, rf modularing frequency 500 MHz, charge per micropulse 0.4 nC, macropulse repetition frequency 10 Hz (max). The gun pulser uses a grid modulated planar triode to drive the gun cathode. The grid driver takes advantage of recently developed modular CATV rf drivers, high performance solid state pulser devices, and high-frequency fiber optic transmitters for telecommunications. Design details are presented with associated SPICE runs simulating operation of the gun

  13. MicroCameras and Photometers (MCP) on board the TARANIS satellite

    Science.gov (United States)

    Farges, T.; Hébert, P.; Le Mer-Dachard, F.; Ravel, K.; Gaillac, S.

    2017-12-01

    TARANIS (Tool for the Analysis of Radiations from lightNing and Sprites) is a CNES micro satellite. Its main objective is to study impulsive transfers of energy between the Earth atmosphere and the space environment. It will be sun-synchronous at an altitude of 700 km. It will be launched in 2019 for at least 2 years. Its payload is composed of several electromagnetic instruments in different wavelengths (from gamma-rays to radio waves including optical). TARANIS instruments are currently in calibration and qualification phase. The purpose is to present the MicroCameras and Photometers (MCP) design, to show its performances after its recent characterization and at last to discuss the scientific objectives and how we want to answer it with the MCP observations. The MicroCameras, developed by Sodern, are dedicated to the spatial description of TLEs and their parent lightning. They are able to differentiate sprite and lightning thanks to two narrow bands ([757-767 nm] and [772-782 nm]) that provide simultaneous pairs of images of an Event. Simulation results of the differentiation method will be shown. After calibration and tests, the MicroCameras are now delivered to the CNES for integration on the payload. The Photometers, developed by Bertin Technologies, will provide temporal measurements and spectral characteristics of TLEs and lightning. There are key instrument because of their capability to detect on-board TLEs and then switch all the instruments of the scientific payload in their high resolution acquisition mode. Photometers use four spectral bands in the [170-260 nm], [332-342 nm], [757-767 nm] and [600-900 nm] and have the same field of view as cameras. The on-board TLE detection algorithm remote-controlled parameters have been tuned before launch using the electronic board and simulated or real events waveforms. After calibration, the Photometers are now going through the environmental tests. They will be delivered to the CNES for integration on the

  14. Center for Worker's Compensation Studies

    Data.gov (United States)

    Federal Laboratory Consortium — The mission of the NIOSH Center for Workers’ Compensation Studies (CWCS) is to use workers’ compensation data and systems to improve workplace safety and health....

  15. Addressing inadequate compensation | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2016-08-12

    Aug 12, 2016 ... The issue LSLAs raise a number of concerns regarding compensation, including ... at a meeting with traders in Lamu, Kenya, where a new port is planned. ... compensation and a fair share of benefits and risks in land deals.

  16. Structuring competitive physician compensation models.

    Science.gov (United States)

    Mobley, Kim; Turcotte, Claire

    2010-12-01

    When developing and reviewing their physician compensation programs, healthcare organizations should: Understand the market data. Test outcomes of incentive plans for fair market value. Check total compensation for fair market value and reasonableness.

  17. RELIABILITY OF LENTICULAR EXPANSION COMPENSATORS

    Directory of Open Access Journals (Sweden)

    Gabriel BURLACU,

    2011-11-01

    Full Text Available Axial lenticular compensators are made to take over the longitudinal heat expansion, shock , vibration and noise, made elastic connections for piping systems. In order to have a long life for installations it is necessary that all elements, including lenticular compensators, have a good reliability. This desire can be did by technology of manufactoring and assembly of compensators, the material for lenses and by maintenance.of compensator

  18. Compensation Consultants and CEO Pay

    NARCIS (Netherlands)

    Kabir, Mohammed Rezaul; Minhat, Marizah

    2014-01-01

    The study examines the practice of employing multiple compensation consultants. Examining data of a sample of UK companies over the period 2003–2006 we find that CEOs receive higher equity-based pay when firms employ more than one compensation consultant. An increase in the number of compensation

  19. MCP detector read out with a bare quad Timepix at kilohertz frame rates

    International Nuclear Information System (INIS)

    Vallerga, J; Tremsin, A; McPhate, J; Siegmund, O; Raffanti, R

    2011-01-01

    The existing Berkeley neutron sensitive MCP/Timepix hybrid detector has been very successful at demonstrating energy resolved spatial imaging with a single Timepix ASIC read out at a ∼ 30 Hz frame rate where each neutron's position and time (energy) is determined (X,Y,E). By increasing the detector format using a quad arrangement of Timepix readouts and increasing the frame rate to 1 kHz, we can increase our total event throughput by a factor of 120, thereby taking full advantage of the high fluxes of modern pulsed neutron sources (10 6 n cm -2 s -1 ). The key to this conversion is a new design for the ASIC readout, called the Berkeley Quad Timepix detector, consisting of 3 major subsystems. The first is a quad (2 x 2) bare Timepix ASIC board mounted directly behind the neutron sensitive MCPs in a hermetic vacuum enclosure with a sapphire window. The data from the Timepix ASICs flow to the second subsystem called the Interface board whose field programmable gate array (FPGA) rearranges and converts the digital bit stream to LVDS logic levels before sending downstream to the third subsystem, the Roach board. The Roach board is also FPGA based, and takes the data from all the ASICs and analyses the frames to extract information on the input events to pass on to the host PC. This paper describes in detail the hardware and firmware designs to accomplish this task.

  20. The MCP Altona incident: the Canadian regulatory response and framework for the export of uranium

    International Nuclear Information System (INIS)

    Lavoie, Jacques

    2012-01-01

    On 23 December 2010, a cargo ship carrying 350 000 kilograms (kg) of uranium ore concentrates (U 3 O 8 ) belonging to the Canadian resource corporation Cameco left Vancouver, British Columbia, Canada and encountered severe weather conditions between Hawaii and the Midway Islands in international waters en route to Zhanjiang, People's Republic of China (PRC). The ship, the MCP Altona, suffered some damage to its hull but was able to continue to operate through the storm. Once the sea had calmed, the crew noticed that some of the containers on the ship had shifted and had been damaged. The captain, however, was unable to secure the necessary authorizations to obtain safe harbour in the area as there were no signs of immediate risk to the health and safety of the ship's crew. On Cameco's recommendation, the ship returned to British Columbia. This article describes the response of the Canadian Nuclear Safety Commission (CNSC) to this incident. The article also discusses the Canadian policy and regulatory framework for controls on the export of uranium

  1. Investigation of image distortion due to MCP electronic readout misalignment and correction via customized GUI application

    Science.gov (United States)

    Vitucci, G.; Minniti, T.; Tremsin, A. S.; Kockelmann, W.; Gorini, G.

    2018-04-01

    The MCP-based neutron counting detector is a novel device that allows high spatial resolution and time-resolved neutron radiography and tomography with epithermal, thermal and cold neutrons. Time resolution is possible by the high readout speeds of ~ 1200 frames/sec, allowing high resolution event counting with relatively high rates without spatial resolution degradation due to event overlaps. The electronic readout is based on a Timepix sensor, a CMOS pixel readout chip developed at CERN. Currently, a geometry of a quad Timepix detector is used with an active format of 28 × 28 mm2 limited by the size of the Timepix quad (2 × 2 chips) readout. Measurements of a set of high-precision micrometers test samples have been performed at the Imaging and Materials Science & Engineering (IMAT) beamline operating at the ISIS spallation neutron source (U.K.). The aim of these experiments was the full characterization of the chip misalignment and of the gaps between each pad in the quad Timepix sensor. Such misalignment causes distortions of the recorded shape of the sample analyzed. We present in this work a post-processing image procedure that considers and corrects these effects. Results of the correction will be discussed and the efficacy of this method evaluated.

  2. Compensability index for compensation radiotherapy after treatment interruptions

    International Nuclear Information System (INIS)

    Putora, Paul Martin; Schmuecking, Michael; Aebersold, Daniel; Plasswilm, Ludwig

    2012-01-01

    The goal of our work was to develop a simple method to evaluate a compensation treatment after unplanned treatment interruptions with respect to their tumour- and normal tissue effect. We developed a software tool in java programming language based on existing recommendations to compensate for treatment interruptions. In order to express and visualize the deviations from the originally planned tumour and normal tissue effects we defined the compensability index. The compensability index represents an evaluation of the suitability of compensatory radiotherapy in a single number based on the number of days used for compensation and the preference of preserving the originally planned tumour effect or not exceeding the originally planned normal tissue effect. An automated tool provides a method for quick evaluation of compensation treatments. The compensability index calculation may serve as a decision support system based on existing and established recommendations

  3. Compensability index for compensation radiotherapy after treatment interruptions

    Directory of Open Access Journals (Sweden)

    Putora Paul

    2012-12-01

    Full Text Available Abstract Background The goal of our work was to develop a simple method to evaluate a compensation treatment after unplanned treatment interruptions with respect to their tumour- and normal tissue effect. Methods We developed a software tool in java programming language based on existing recommendations to compensate for treatment interruptions. In order to express and visualize the deviations from the originally planned tumour and normal tissue effects we defined the compensability index. Results The compensability index represents an evaluation of the suitability of compensatory radiotherapy in a single number based on the number of days used for compensation and the preference of preserving the originally planned tumour effect or not exceeding the originally planned normal tissue effect. An automated tool provides a method for quick evaluation of compensation treatments. Conclusions The compensability index calculation may serve as a decision support system based on existing and established recommendations.

  4. Stability and performance studies of the PITZ photoelectron gun

    International Nuclear Information System (INIS)

    Isaev, Igor

    2018-02-01

    The invention of free electron lasers (FELs) opened new opportunities for the investigation of natural phenomena. However, the operation of a FEL requires high energy, high peak current electron beams with very small transverse emittance which causes extreme requirements for the corresponding electron sources. Besides the high beam quality, the electron sources must have very high operational stability and reliability. One of the electron source types which satisfy FEL requirements is a photoelectron gun. Photoelectron guns combine photoemissive electron generation and direct acceleration in a Radio Frequency (RF) cavity. The Photo Injector Test facility at DESY, Zeuthen site (PITZ), was established as a test stand of the electron source for FELs like FLASH and the European XFEL in Hamburg. The studies of the beam emittance at PITZ showed that the gun is able to produce electron beams with emittance even smaller than it is required by XFEL specifications. But the experiments on the emittance revealed discrepancies between expected gun behavior and observation, such as the difference in optimal parameters for the smallest emittance value, asymmetry of the transverse beam profile and the phase spaces. The work performed at PITZ includes preparation of several RF guns for their subsequent operation at FLASH and the European XFEL. RF conditioning of a gun cavity is one of the major steps of the preparation of a high brightness electron source required for modern FELs. A thorough procedure is applied to increase the peak and average RF power in the gun cavity, including an increase of the repetition rate and RF pulse length combined with a gun solenoid current sweep. The main goals of this thesis are: (1) an attempt of deep understanding of physical processes taking place during operation of a photoelectron gun (conditioning process, parameters adjustments); (2) definition of operational problems sources and explanation of the experimentally obtained results in the gun

  5. Stability and performance studies of the PITZ photoelectron gun

    Energy Technology Data Exchange (ETDEWEB)

    Isaev, Igor

    2018-02-15

    The invention of free electron lasers (FELs) opened new opportunities for the investigation of natural phenomena. However, the operation of a FEL requires high energy, high peak current electron beams with very small transverse emittance which causes extreme requirements for the corresponding electron sources. Besides the high beam quality, the electron sources must have very high operational stability and reliability. One of the electron source types which satisfy FEL requirements is a photoelectron gun. Photoelectron guns combine photoemissive electron generation and direct acceleration in a Radio Frequency (RF) cavity. The Photo Injector Test facility at DESY, Zeuthen site (PITZ), was established as a test stand of the electron source for FELs like FLASH and the European XFEL in Hamburg. The studies of the beam emittance at PITZ showed that the gun is able to produce electron beams with emittance even smaller than it is required by XFEL specifications. But the experiments on the emittance revealed discrepancies between expected gun behavior and observation, such as the difference in optimal parameters for the smallest emittance value, asymmetry of the transverse beam profile and the phase spaces. The work performed at PITZ includes preparation of several RF guns for their subsequent operation at FLASH and the European XFEL. RF conditioning of a gun cavity is one of the major steps of the preparation of a high brightness electron source required for modern FELs. A thorough procedure is applied to increase the peak and average RF power in the gun cavity, including an increase of the repetition rate and RF pulse length combined with a gun solenoid current sweep. The main goals of this thesis are: (1) an attempt of deep understanding of physical processes taking place during operation of a photoelectron gun (conditioning process, parameters adjustments); (2) definition of operational problems sources and explanation of the experimentally obtained results in the gun

  6. Ação do 1-metilciclopropeno (1-MCP na vida de prateleira da banana 'maçã' Action of 1-methylcyclopropene (1-MCP on shelf life of 'apple' banana

    Directory of Open Access Journals (Sweden)

    Ana Carla Marques Pinheiro

    2005-04-01

    Full Text Available Objetivou-se avaliar o efeito do 1-metilciclopropeno (1-MCP, em diferentes concentrações, sobre a vida pós-colheita e sob as variáveis associadas aos atributos de qualidade de banana 'Maçã'. Frutos verde-maturos foram submetidos a cinco concentrações de 1-MCP (0; 50; 100; 150 e 200 etaL.L-1, por 12 horas, e foram analisados durante o amadurecimento sob condição ambiente (20±1ºC e 80±5% UR. O tratamento com 50 etaL.L-1 de 1-MCP atrasou o início do amadurecimento das bananas em aproximadamente 8 dias, baseando-se nas primeiras mudanças de coloração da casca, enquanto os tratamentos 100; 150 e 200 etaL.L-1 atrasaram-no em aproximadamente 10 dias. Observou-se, durante o amadurecimento, o amaciamento dos frutos, associado à conversão de amido em açúcares e ao aumento na solubilização péctica e na atividade da pectinametilesterase (PME e poligalacturonase (PG. A aplicação de 50 etaL.L-1de 1-MCP é a mais adequada por promover a extensão da vida de prateleira de bananas 'Maçã', preservando sua qualidade com base nas análises de açúcares solúveis totais, pectinas total e solúvel, firmeza e aparência externa ao final do armazenamento.The objective of this work was to evaluate the influence of the 1-MCP, at different concentrations, on quality and shelf life of 'Apple' banana. Green mature fruits were submitted to five concentrations of 1-MCP (0, 50, 100, 150 and 200 etaL.L-1, for 12 hours and analyzed during the ripening at room temperature (20ºC ± 1 and 80% ± 5 RH . The 1-MCP at 50 etaL.L-1 delayed, in 8 days, the begining of the ripening, based in the first changes of peel color, whereas 100, 150 and 200 etaL.L-1 treatments delayed the begining of the ripening in 10 days, in comparison to the control. The softening of the fruits, associated to the conversion of starch in sugar and the increasing in the pectic solubilization and activity of pectinmethylsterase and polygalacturonase, was observed during the ripening

  7. Electron emission and plasma generation in a modulator electron gun using ferroelectric cathode

    International Nuclear Information System (INIS)

    Chen Shutao; Zheng Shuxin; Zhu Ziqiu; Dong Xianlin; Tang Chuanxiang

    2006-01-01

    Strong electron emission and dense plasma generation have been observed in a modulator electron gun with a Ba 0.67 Sr 0.33 TiO 3 ferroelectric cathode. Parameter of the modulator electron gun and lifetime of the ferroelectric cathode were investigated. It was shown that electron emission from Ba 0.67 Sr 0.33 TiO 3 cathode with a positive triggering pulse is a sort of plasma emission. Electrons were emitted by the co-effect of surface plasma and non-compensated negative polarization charges at the surface of the ferroelectric. The element analyses of the graphite collector after emission process was performed to show the ingredient of the plasma consist of Ba, Ti and Cu heavy cations of the ceramic compound and electrode. It was demonstrated the validity of the Child-Langmuir law by introducing the decrease of vacuum gap and increase of emission area caused by the expansion of the surface plasma

  8. Crystallization and crystallographic analysis of the ligand-binding domain of the Pseudomonas putida chemoreceptor McpS in complex with malate and succinate

    International Nuclear Information System (INIS)

    Gavira, J. A.; Lacal, J.; Ramos, J. L.; García-Ruiz, J. M.; Krell, T.; Pineda-Molina, E.

    2012-01-01

    The crystallization of the ligand-binding domain of the methyl-accepting chemotaxis protein chemoreceptor McpS (McpS-LBD) is reported. Methyl-accepting chemotaxis proteins (MCPs) are transmembrane proteins that sense changes in environmental signals, generating a chemotactic response and regulating other cellular processes. MCPs are composed of two main domains: a ligand-binding domain (LBD) and a cytosolic signalling domain (CSD). Here, the crystallization of the LBD of the chemoreceptor McpS (McpS-LBD) is reported. McpS-LBD is responsible for sensing most of the TCA-cycle intermediates in the soil bacterium Pseudomonas putida KT2440. McpS-LBD was expressed, purified and crystallized in complex with two of its natural ligands (malate and succinate). Crystals were obtained by both the counter-diffusion and the hanging-drop vapour-diffusion techniques after pre-incubation of McpS-LBD with the ligands. The crystals were isomorphous and belonged to space group C2, with two molecules per asymmetric unit. Diffraction data were collected at the ESRF synchrotron X-ray source to resolutions of 1.8 and 1.9 Å for the malate and succinate complexes, respectively

  9. Monte Carlo Simulations of High-speed, Time-gated MCP-based X-ray Detectors: Saturation Effects in DC and Pulsed Modes and Detector Dynamic Range

    International Nuclear Information System (INIS)

    Kruschwitz, Craig; Ming Wu; Moy, Ken; Rochau, Greg

    2008-01-01

    We present here results of continued efforts to understand the performance of microchannel plate (MCP)-based, high-speed, gated, x-ray detectors. This work involves the continued improvement of a Monte Carlo simulation code to describe MCP performance coupled with experimental efforts to better characterize such detectors. Our goal is a quantitative description of MCP saturation behavior in both static and pulsed modes. We have developed a new model of charge buildup on the walls of the MCP channels and measured its effect on MCP gain. The results are compared to experimental data obtained with a short-pulse, high-intensity ultraviolet laser; these results clearly demonstrate MCP saturation behavior in both DC and pulsed modes. The simulations compare favorably to the experimental results. The dynamic range of the detectors in pulsed operation is of particular interest when fielding an MCP-based camera. By adjusting the laser flux we study the linear range of the camera. These results, too, are compared to our simulations

  10. Gun violence in Americans' social network during their lifetime.

    Science.gov (United States)

    Kalesan, Bindu; Weinberg, Janice; Galea, Sandro

    2016-12-01

    The overall burden of gun violence death and injury in the US is now well understood. However, no study has shown the extent to which gun violence is associated with the individual lives of Americans. We used fatal and non-fatal gun injury rates in 2013 from Centers for Disease Control and Prevention's Web-based Injury Statistics Query and Reporting System (WISQARS) and generally accepted estimates about the size of an American's social network to determine the likelihood that any given person will know someone in their personal social network who is a victim of gun violence during their lifetime. We derived estimates in the overall population and among racial/ethnic groups and by gun-injury intent. The likelihood of knowing a gun violence victim within any given personal network over a lifetime is 99.85% (99.8% to 99.9%). The likelihood among non-Hispanic white, black, Hispanic and other race Americans were 97.1%, 99.9%, 99.5% and 88.9% respectively. Nearly all Americans of all racial/ethnic groups are likely to know a victim of gun violence in their social network during their lifetime. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. The PLX- α Plasma Guns: Progress and Plans

    Science.gov (United States)

    Witherspoon, F. D.; Brockington, S.; Case, A.; Cruz, E.; Luna, M.; Thio, Y. C. Francis; LANL PLX-α Team

    2017-10-01

    The ALPHA coaxial plasma guns are being developed to support a 60-gun scaling study of spherically imploding plasma liners as a standoff driver for plasma-jet-driven magneto-inertial fusion (PJMIF). Seven complete guns have been delivered to LANL with 6 guns currently undergoing simultaneous test firings on PLX. The guns are designed to operate over a range of parameters: 0.5-5.0 mg of Ar, Ne, N2, Kr, and Xe; 20-60 km/s; 2 × 1016 cm-3 muzzle density; and up to 7.5 kJ stored energy per gun. Each coaxial gun incorporates a fast dense gas injection and triggering system, a compact low-weight pfn with integral sparkgap switching, and a contoured coaxial gap to suppress the blow-by instability. Optimizing parameter scans performed at HyperV have achieved : 4 mg at >50 km/s and length of 10 cm. Peak axial density 30 cm from the muzzle is 2 ×1016 cm-3. We will provide an overview of the experimental results, along with plans for further improvements in reliability, maintainability, fabricability, and plasma jet performance, with the latter focused on further improvements in the fast gas valve and the ignitors. This work supported by the ARPA-E ALPHA Program under contract DE-AR0000566 and Strong Atomics, LLC.

  12. Correlation of MCP-4 and high-sensitivity C-reactive protein as a marker of inflammation in obesity and chronic periodontitis.

    Science.gov (United States)

    Pradeep, A R; Kumari, Minal; Kalra, Nitish; Priyanka, N

    2013-03-01

    Obesity is increasing in prevalence worldwide and has emerged as a strong risk factor for periodontal disease. Conversely, the remote effects of periodontal disease on various systemic diseases have been proposed. The aim of this study is to determine the presence of MCP-4 and high sensitivity C reactive protein (hsCRP) levels in gingival crevicular fluid (GCF) and serum in obese and non-obese subjects with chronic periodontitis and to find a correlation between MCP-4 and hsCRP in GCF and serum. Forty subjects (20 males and 20 females) were selected and divided into four groups (10 subjects in each group), based on clinical parameters: group NOH (non-obese healthy), group OH (obese healthy), Group NOCP (non-obese with chronic periodontitis) and group OCP (obese with chronic periodontitis). The levels of serum and GCF MCP-4 were determined by ELISA and hsCRP levels were determined by immunoturbidimetry method. The mean GCF and serum concentration of MCP-4 was highest for group OCP followed by group NOCP, group OH (in GCF); group OH, group NOCP(in serum) and least in group NOH. The mean hsCRP concentration was highest for group OCP followed by group OH, group NOCP and group NOH. A significant positive correlation was found between serum and GCF MCP-4 and hsCRP levels. GCF MCP-4 concentrations increased in periodontal disease compared to health and correlated positively with the severity of disease indicating it as a novel marker of periodontal disease. The serum concentration of MCP-4 was found to be more in obese group as compared to nonobese group indicating it as a marker of obesity. Furthermore, based on the positive correlation of MCP-4 and hsCRP found in this study, it can be proposed that MCP-4 and hsCRP may be the markers linking chronic inflammation in obesity and periodontal disease. Copyright © 2013 Elsevier Ltd. All rights reserved.

  13. Qualidade pós-colheita de quivi 'Hayward' tratado com 1-MCP e armazenado sob diferentes atmosferas

    Directory of Open Access Journals (Sweden)

    Marcelo José Vieira

    2012-06-01

    Full Text Available Este trabalho teve por objetivo avaliar o efeito do 1-MCP sobre o amadurecimento e a qualidade pós-colheita de quivi 'Hayward' armazenado sob diferentes atmosferas. Foram conduzidos dois experimentos, com frutos colhidos em pomar comercial localizado em Fraiburgo-SC. No experimento 1, os frutos foram tratados com três doses de 1-MCP (0,0; 0,5 ou 1,0 µL L-1 e armazenados sob atmosfera controlada (AC, contendo 2,0kPa de O2 + 4,5kPa de CO2, a 0ºC ± 0,5ºC, 92 ± 3% UR, e com <40 ηL L-1 de etileno no ambiente, durante 90 e 120 dias, mais sete dias de vida de prateleira a 23ºC. No experimento 2, os frutos foram tratados com 0,0 ou 0,7 µL L-1 de 1-MCP e armazenados sob atmosfera ambiente (AA, contendo 21 kPa de O2 + 0,03 kPa de CO2, a 0 ± 0,5ºC, 90 ± 3% UR, e com 200 a 250 ηL L-1 de etileno no ambiente, durante 30, 60, 90 e 120 dias, mais um e sete dias de vida de prateleira a 23ºC ou AC (contendo 2,0 kPa de O2 + 4,5 kPa de CO2, a 0ºC ± 0,5ºC, 92 ± 3% UR, e com <40 ηL L-1 de etileno no ambiente, durante 60, 90, 120 e 150 dias, mais um e sete dias de vida de prateleira a 23ºC. Os benefícios do tratamento com 1-MCP sobre a conservação da qualidade foram observados tanto para frutos armazenados sob AA quanto sob AC. No experimento 1, não houve diferença entre as doses de 1-MCP de 0,5 e 1,0 µL L-1 sobre o controle do amadurecimento e manutenção da qualidade dos frutos armazenados em AC. No experimento 2, o tratamento com 1-MCP retardou o aumento na taxa de produção de etileno após remoção de câmara fria. A redução da taxa de produção de etileno nos frutos tratados com 1-MCP foi associada ao aumento na conservação da firmeza da polpa sob AC e AA, e redução na incidência de pericarpo translúcido sob AA. O potencial de armazenamento foi aumentado pelo tratamento com 1-MCP em aproximadamente 60 e 30 dias, nos frutos armazenados sob AA e AC, respectivamente.

  14. TRAIL: a tokamak rail gun limiter

    International Nuclear Information System (INIS)

    Yu, W.S.; Powell, J.R.; Usher, J.L.

    1980-01-01

    An attractive new limiter concept is investigated. The TRAIL (Tokamak Rail Gun Limiter) system impacts a stream of moderate velocity pellets (100 to 200 m/sec through the plasma edge region to absorb energy and define the plasma boundary. The pellets are recycled after cooling, to the injector of an E-M mass accelerator. Heat fluxes of approx. 30,000 W/cm 2 can be readily accommodated by the pellets, with very low recirculating power requirements (approx. 0.1%) for the accelerator. The mass accelerator velocity requirements are well within the present state of the art (several Km/sec). Accelerators injecting pellets at approx. 1 Km/sec can be used to control local plasma temperature and current profiles and to act as energy absorbers to shut down the plasma without damage to the first wall if a plasma disruption occurs

  15. Electrical model of cold atmospheric plasma gun

    Science.gov (United States)

    Slutsker, Ya. Z.; Semenov, V. E.; Krasik, Ya. E.; Ryzhkov, M. A.; Felsteiner, J.; Binenbaum, Y.; Gil, Z.; Shtrichman, R.; Cohen, J. T.

    2017-10-01

    We present an analytical model of cold atmospheric plasma formed by a dielectric barrier discharge (DBD), which is based on the lumped and distributed elements of an equivalent electric circuit of this plasma. This model is applicable for a wide range of frequencies and amplitudes of the applied voltage pulses, no matter whether or not the generated plasma plume interacts with a target. The model allows quantitative estimation of the plasma plume length and the energy delivered to the plasma. Also, the results of this model can be used for the design of DBD guns which efficiently generate cold atmospheric plasma. A comparison of the results of the model with those obtained in experiments shows a fairly good agreement.

  16. Gridded X-ray tube gun

    International Nuclear Information System (INIS)

    1975-01-01

    An X-ray generator has a Pierce type electron gun comprising an electron emissive cathode with field shaping electrodes, a first accelerating anode spaced from the cathode, and an X-ray target anode spaced from the accelerating anode for being impinged upon by a focused electron beam. Control grid means are disposed between the cathode and the first anode. The grid means are constructed such that with use of proper grid potentials, the electron beam may be selectively biased to cutoff, or electrons can be withdrawn from selected areas of the cathode or from the entire cathode to produce focal spots of different sizes and various electron current magnitudes on the target anode

  17. Power conditioner for a coil-gun

    International Nuclear Information System (INIS)

    Zabar, Z.; Joshi, P.N.

    1987-01-01

    This paper describes a power conditioning scheme for introducing currents sequentially into a linear array of coils which form the barrel of a coil-gun. The projectile, a conducting cylindrical sleeve, is driven by the force exerted on it by a traveling magnetic wave-packet created by the barrel currents. Since the rate of energy transfer is proportional to the projectile velocity, it was convenient to divide the barrel into three separate sections. These correspond to the low, medium and high velocity parts of the projectile motion. Each section is excited by a different method, chosen to satisfy the need for most efficient usage of energy stored in the power supply capacitors. Experiments are described with a breadboard model that test the feasibility of the medium-velocity power conditioning scheme

  18. Projectile Balloting Attributable to Gun Tube Curvature

    Directory of Open Access Journals (Sweden)

    Michael M. Chen

    2010-01-01

    Full Text Available Transverse motion of a projectile during launch is detrimental to firing accuracy, structural integrity, and/or on-board electronics performance of the projectile. One manifest contributing factor to the undesired motion is imperfect bore centerline straightness. This paper starts with the presentation of a deterministic barrel model that possesses both vertical and lateral deviations from centerline in accordance with measurement data, followed by a novel approach to simulating comprehensive barrel centerline variations for the investigation of projectile balloting^1 motions. A modern projectile was adopted for this study. In-bore projectile responses at various locations of the projectile while traveling through the simulated gun tubes were obtained. The balloting was evaluated in both time and frequency domains. Some statistical quantities and the significance were outlined.

  19. Impact fusion with a segmented rail gun

    International Nuclear Information System (INIS)

    Muller, R.A.; Garwin, R.L.; Richter, B.

    1979-01-01

    The basic rail gun equations are reviewed. The delivery of E = 1 megajoule in dt = 10 nanoseconds, with a specific energy of 20 MJ/g (i.e., a bullet mass of 0.05 g) is considered. These values are taken from the requirements being considered for heavy-ion fusion. Using these numbers, we can solve immediately for the final particle velocity u/sub f/ from E = 1/2 mu/sub f/ 2 to get u/sub f/ = 200 km/sec. For a delivery time of 10 nanoseconds, this velocity implies that the projectile length is about 2 mm. Impact fusion is feasible because of the coincidence that a bullet with all dimensions roughly 2 mm has the required mass

  20. Fundamental relativistic solution for the rail gun

    International Nuclear Information System (INIS)

    Liboff, R.L.; Schenter, G.K.

    1986-01-01

    A fully relativistic analysis is made of the dynamics of a rail gun based on three assumptions: (1) Ohm's law is valid in the rest frame of the plasma, (2) total electron momentum is transferred to the projectile, and (3) motion of the projectile is constrained to one direction. With these assumptions, a relativistic equation for the velocity of the projectile is obtained, whose solution monotonically increases to one of two values depending on field strengths. For B>E, the maximum velocity is cE/B, whereas for E>B it is c, where c is the speed of light, and E and B are applied electric and magnetic fields, respectively (in cgs)

  1. Smart Gun Technology project. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Weiss, D.R.

    1996-05-01

    The goal of the Smart Gun Technology project is to eliminate the capability of an unauthorized user form firing a law officer`s firearm by implementing user-recognizing-and-authorizing (or {open_quotes}smart{close_quotes}) surety technologies. This project was funded by the National Institute of Justice. This report lists the findings and results of the project`s three primary objectives. First, to find and document the requirements for a smart firearm technology that law enforcement officers will value. Second, to investigate, evaluate, and prioritize technologies that meet the requirements for a law enforcement officer`s smart firearm. Third, to demonstrate and document the most promising technology`s usefulness in models of a smart firearm.

  2. Dynamics of a coaxial plasma gun

    International Nuclear Information System (INIS)

    Raadu, M.A.

    1977-01-01

    The dynamics of an ionizing wave in a coaxial plasma gun with an azimuthal bias magnetic field is analysed in a theoretical model. Only the radial dependence is treated and instead of including a treatment of the energy balance two separate physical assumptions are made. In the first case it is assumed that the total internal electric field is given by the critical ionization velocity condition and in the second that the ionization rate is constant. For consistency wall sheaths are assumed to match the internal plasma potential to that of the walls. On the basis of momentum and particle balance the radial dependence of the electron density, current density, electric field and drift velocity are found. An electron source is required at the cathode and the relative contribution from ionization within the plasma is deduced. The assumption that there are no ion sources at the electrodes leads to a restriction on the possible values of the axial electric field. (Auth.)

  3. EFECTO DEL 1-METILCICLOPROPENO (1-MCP SOBRE LA FISIOLOGÍA Y CALIDAD DE FRUTOS DE JACA (Artocarpus heterophyllus Lam.

    Directory of Open Access Journals (Sweden)

    M. Mata-Montes de Oca

    2007-01-01

    Full Text Available Debido a sus características de color y sabor de pulpa, la demanda de fruta de jaca se ha incrementado considerablemente. La mayoría de la producción de Nayarit es exportada a los Estados Unidos de Norteamérica. Sin embargo, debido a su corta vida de anaquel y susceptibilidad al daño por frío la fruta es exportada vía aérea con altos costos de flete. Se reporta que el 1-Metilciclopropeno (1-MCP retarda el proceso de madurez, alarga la vida de anaquel y mantiene la calidad de varios frutales, así que el objetivo de este estudio fue evaluar el efecto del 1-MCP sobre la fisiología y calidad del fruto de jaca almacenado a 20 ºC. Las frutas fueron cosechadas en madurez fisiológica, lavadas y tratadas con 1-MCP a 100 y 300 nl·litro-1 en cámaras selladas por 12 h a 20 ± 1 ºC; 85 ± 5 % de HR manteniendo un testigo sin tratar. Las variables evaluadas fueron: velocidad de respiración y de producción de etileno, sólidos solubles totales, acidez titulable, firmeza de la pulpa y de la fruta entera, color en la pulpa y pérdida de peso. El 1-MCP no afectó la mayoría de las variables de calidad pero retrasó significativamente la velocidad de respiración y la producción de etileno así como el ablandamiento de la pulpa, lo que permitió prolongar la vida de anaquel hasta por ocho y 12 días a 100 y 300 nl·litro-1, respectivamente.

  4. Aumento da expressão do MCP-1 coroidal e escleral em modelo experimental de hipercolesterolemia

    Directory of Open Access Journals (Sweden)

    Rogil José de Almeida Torres

    2012-02-01

    Full Text Available OBJETIVO: O objetivo deste trabalho é demonstrar experimentalmente que a dieta rica em colesterol provoca aumento da expressão da MCP-1 na coroide e esclera. MÉTODO: Coelhos New Zealand foram organizados em dois grupos: GN (grupo dieta normal, composto por 8 coelhos (8 olhos, recebeu ração padrão para coelhos, durante 4 semanas; GH (grupo hipercolesterolêmico, composto por 13 coelhos (13 olhos, recebeu dieta rica em colesterol a 1% por 8 semanas. Foi realizada a dosagem sérica de colesterol total, triglicerídeos, HDL colesterol, glicemia de jejum no início do experimento e no momento da eutanásia. Ao final da 8ª semana para o GH e 4ª semana para o GN foi realizada a eutanásia dos animais e os olhos foram submetidos à análise imuno-histoquímica com o anticorpo anti-MCP-1. RESULTADOS: A dieta provocou significativo aumento do colesterol total e triglicerídeos do GH em relação ao GN (p<0,001. Houve significativo aumento da expressão da MCP-1 na coroide e esclera dos animais do GH em relação ao GN (p<0,001. CONCLUSÃO: Este estudo demonstrou que a dieta hipercolesterolêmica em coelhos induz ao aumento da expressão do MCP-1 na coroide e esclera.

  5. Analytical solution for a coaxial plasma gun: Weak coupling limit

    International Nuclear Information System (INIS)

    Dietz, D.

    1987-01-01

    The analytical solution of the system of coupled ODE's which describes the time evolution of an ideal (i.e., zero resistance) coaxial plasma gun operating in the snowplow mode is obtained in the weak coupling limit, i.e, when the gun is fully influenced by the driving (RLC) circuit in which it resides but the circuit is negligibly influenced by the gun. Criteria for the validity of this limit are derived and numerical examples are presented. Although others have obtained approximate, asymptotic and numerical solutions of the equations, the present analytical results seem not to have appeared previously in the literature

  6. Commentary: evidence to guide gun violence prevention in America.

    Science.gov (United States)

    Webster, Daniel W

    2015-03-18

    Gun violence is a major threat to the public's health and safety in the United States. The articles in this volume's symposium on gun violence reveal the scope of the problem and new trends in mortality rates from gunfire. Leading scholars synthesize research evidence that demonstrates the ability of numerous policies and programs-each consistent with lessons learned from successful efforts to combat public health problems-to prevent gun violence. Each approach presents challenges to successful implementation. Future research should inform efforts to assess which approaches are most effective and how to implement evidence-based interventions most effectively.

  7. Note: Characteristic beam parameter for the line electron gun

    Science.gov (United States)

    Iqbal, M.; Islam, G. U.; Zhou, Z.; Chi, Y.

    2013-11-01

    We have optimized the beam parameters of line source electron gun using Stanford Linear Accelerator Centre electron beam trajectory program (EGUN), utilizing electrostatic focusing only. We measured minimum beam diameter as 0.5 mm that corresponds to power density of 68.9 kW/cm2 at 13.5 mm in the post-anode region which is more than two-fold (33 kW/cm2), of the previously reported results. The gun was operated for the validation of the theoretical results and found in good agreement. The gun is now without any magnetic and electrostatic focusing thus much simpler and more powerful.

  8. Note: Characteristic beam parameter for the line electron gun

    Energy Technology Data Exchange (ETDEWEB)

    Iqbal, M. [Centre for High Energy Physics, University of the Punjab, Lahore 45590 (Pakistan); Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); Islam, G. U. [Centre for High Energy Physics, University of the Punjab, Lahore 45590 (Pakistan); Zhou, Z.; Chi, Y. [Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China)

    2013-11-15

    We have optimized the beam parameters of line source electron gun using Stanford Linear Accelerator Centre electron beam trajectory program (EGUN), utilizing electrostatic focusing only. We measured minimum beam diameter as 0.5 mm that corresponds to power density of 68.9 kW/cm{sup 2} at 13.5 mm in the post-anode region which is more than two-fold (33 kW/cm{sup 2}), of the previously reported results. The gun was operated for the validation of the theoretical results and found in good agreement. The gun is now without any magnetic and electrostatic focusing thus much simpler and more powerful.

  9. Note: Characteristic beam parameter for the line electron gun

    International Nuclear Information System (INIS)

    Iqbal, M.; Islam, G. U.; Zhou, Z.; Chi, Y.

    2013-01-01

    We have optimized the beam parameters of line source electron gun using Stanford Linear Accelerator Centre electron beam trajectory program (EGUN), utilizing electrostatic focusing only. We measured minimum beam diameter as 0.5 mm that corresponds to power density of 68.9 kW/cm 2 at 13.5 mm in the post-anode region which is more than two-fold (33 kW/cm 2 ), of the previously reported results. The gun was operated for the validation of the theoretical results and found in good agreement. The gun is now without any magnetic and electrostatic focusing thus much simpler and more powerful

  10. Dynamic Response and Fracture of Composite Gun Tubes

    Directory of Open Access Journals (Sweden)

    Jerome T. Tzeng

    2001-01-01

    Full Text Available The fracture behavior due to dynamic response in a composite gun tube subjected to a moving pressure has been investigated. The resonance of stress waves result in very high amplitude and frequency strains in the tube at the instant and location of pressure front passage as the velocity of the projectile approaches a critical value. The cyclic stresses can accelerate crack propagation in the gun tube with an existing imperfection and significantly shorten the fatigue life of gun tubes. The fracture mechanism induced by dynamic amplification effects is particularly critical for composite overwrap barrels because of a multi-material construction, anisotropic material properties, and the potential of thermal degradation.

  11. Function of bunching segment in multi-cell RF gun

    International Nuclear Information System (INIS)

    Yang Xingfan; Xu Zhou Liu Xisan

    2001-01-01

    With a bunching segment and a shortened first cell, the 4 + 1/2 cell RF gun produced in CAEP has been proved experimentally to be effective in reducing electron back bombardment. The analysis of the electric field distribution and electron motion in bunching segment of multi-cell RF gun is presented. The electron capture efficiency and electron trajectory with different initial phase are calculated using Runge-Kutta method. The function of the bunching segment is discussed. The calculated parameters of the 4 + 1/2 cell RF gun agree well with the experimental results

  12. Note: Characteristic beam parameter for the line electron gun.

    Science.gov (United States)

    Iqbal, M; Islam, G U; Zhou, Z; Chi, Y

    2013-11-01

    We have optimized the beam parameters of line source electron gun using Stanford Linear Accelerator Centre electron beam trajectory program (EGUN), utilizing electrostatic focusing only. We measured minimum beam diameter as 0.5 mm that corresponds to power density of 68.9 kW/cm(2) at 13.5 mm in the post-anode region which is more than two-fold (33 kW/cm(2)), of the previously reported results. The gun was operated for the validation of the theoretical results and found in good agreement. The gun is now without any magnetic and electrostatic focusing thus much simpler and more powerful.

  13. Analysis on a electron gun for metal fusion

    International Nuclear Information System (INIS)

    Paes, A.C.J.; Galvao, R.M.O.; Boscolo, P.; Passaro, A.

    1987-09-01

    The characteristics of the electron beam of the HK-011600 Δ, electron gun for metal fusion at the 'Divisao de Materiais do Instituto de Pesquisa e Desenvolvimento do CTA (PMR/IPD/CTA)', is analyzed. In this analysis, the Pierce gun model and the SLAC computational code for electron optics are used. The electron beam R and Z profiles are obtained in the gun region and in the magnetic lenses region. The behaviour of the electron beam in the prism region is also discussed using a simple model. (author) [pt

  14. Method of electron emission control in RF guns

    International Nuclear Information System (INIS)

    Khodak, I.V.; Kushnir, V.A.

    2001-01-01

    The electron emission control method for a RF gun is considered.According to the main idea of the method,the additional resonance system is created in a cathode region where the RF field strength could be varied using the external pulse equipment. The additional resonance system is composed of a coaxial cavity coupled with a RF gun cylindrical cavity via an axial hole. Computed results of radiofrequency and electrodynamic performances of such a two-cavity system and results of the RF gun model pilot study are presented in. Results of particle dynamics simulation are described

  15. Method of electron emission control in RF guns

    CERN Document Server

    Khodak, I V

    2001-01-01

    The electron emission control method for a RF gun is considered.According to the main idea of the method,the additional resonance system is created in a cathode region where the RF field strength could be varied using the external pulse equipment. The additional resonance system is composed of a coaxial cavity coupled with a RF gun cylindrical cavity via an axial hole. Computed results of radiofrequency and electrodynamic performances of such a two-cavity system and results of the RF gun model pilot study are presented in. Results of particle dynamics simulation are described.

  16. Design studies on high current and grid control electron gun

    International Nuclear Information System (INIS)

    Wang Jinnan; Lu Kun; Chi Yunlong; Zhou Zusheng

    2011-01-01

    Electron gun, the source of electrons, is a kind of ultrahigh vacuum device and plays an important role in different kind of accelerators. With the irradiation accelerator demands, describes the design studies on beam optics optimization. The simulation result shows that the beam current is above 5 A with cathode voltage of 80 kV and beam emittance, gun electric field and beam waist radius meet the accelerator needs. The electron gun manufactured and installed in the test stand, the conditioning and test will be done in the near future. (authors)

  17. Summary, Working Group 1: Electron guns and injector designs

    International Nuclear Information System (INIS)

    Ben-Zvi, I.; Bazarov, I.V.

    2006-01-01

    We summarize the proceedings of Working Group 1 of the 2005 Energy Recovery Linac (ERL) Workshop. The subject of this working group, the electron gun and injector design, is arguably the most critical part of the ERL as it determines the ultimate performance of this type of accelerators. Working Group 1 dealt with a variety of subjects: The technology of DC, normal-conducting RF and superconducting RF guns; beam dynamics in the gun and injector; the cathode and laser package; modeling and computational issues; magnetized beams and polarization. A short overview of these issues covered in the Working Group is presented in this paper

  18. Fukushima: liability and compensation

    International Nuclear Information System (INIS)

    Vasquez-Maignan, Ximena

    2012-01-01

    On 11 March 2011, Japan endured one of the worst natural disasters in its history when a massive earthquake struck the Pacific coast of the country and was followed by a tsunami which led to considerable loss of lives. It also led to a major accident at the Fukushima Daiichi nuclear power plant. Soon afterwards, the operator of the plant, Tokyo Electric Power Company (TEPCO), assumed responsibility and liability for the nuclear accident. On 28 April 2011, TEPCO established a dedicated contact line to provide consulting services for financial compensation related to the damage caused

  19. Spatially and Temporally Regulated NRF2 Gene Therapy Using Mcp-1 Promoter in Retinal Ganglion Cell Injury

    Directory of Open Access Journals (Sweden)

    Kosuke Fujita

    2017-06-01

    Full Text Available Retinal ganglion cell degeneration triggered by axonal injury is believed to underlie many ocular diseases, including glaucoma and optic neuritis. In these diseases, retinal ganglion cells are affected unevenly, both spatially and temporally, such that healthy and unhealthy cells coexist in different patterns at different time points. Herein, we describe a temporally and spatially regulated adeno-associated virus gene therapy aiming to reduce undesired off-target effects on healthy retinal neurons. The Mcp-1 promoter previously shown to be activated in stressed retinal ganglion cells following murine optic nerve injury was combined with the neuroprotective intracellular transcription factor Nrf2. In this model, Mcp-1 promoter-driven NRF2 expression targeting only stressed retinal ganglion cells showed efficacy equivalent to non-selective cytomegalovirus promoter-driven therapy for preventing cell death. However, cytomegalovirus promoter-mediated NRF2 transcription induced cellular stress responses and death of Brn3A-positive uninjured retinal ganglion cells. Such undesired effects were reduced substantially by adopting the Mcp-1 promoter. Combining a stress-responsive promoter and intracellular therapeutic gene is a versatile approach for specifically targeting cells at risk of degeneration. This strategy may be applicable to numerous chronic ocular and non-ocular conditions.

  20. Brief use of a specific gun in a violent game does not affect attitudes towards that gun.

    Science.gov (United States)

    Hilgard, Joseph; Engelhardt, Christopher R; Bartholow, Bruce D

    2016-11-01

    Although much attention has been paid to the question of whether violent video games increase aggressive behaviour, little attention has been paid to how such games might encourage antecedents of gun violence. In this study, we examined how product placement, the attractive in-game presentation of certain real-world firearm brands, might encourage gun ownership, a necessary antecedent of gun violence. We sought to study how the virtual portrayal of a real-world firearm (the Bushmaster AR-15) could influence players' attitudes towards the AR-15 specifically and gun ownership in general. College undergraduates ( N  = 176) played one of four modified video games in a 2 (gun: AR-15 or science-fiction control) × 2 (gun power: strong or weak) between-subjects design. Despite collecting many outcomes and examining many potential covariates and moderators, experimental assignment did little to influence outcomes of product evaluations or purchasing intentions with regard to the AR-15. Attitudes towards public policy and estimation of gun safety were also not influenced by experimental condition, although these might have been better tested by comparison against a no-violence control condition. By contrast, gender and political party had dramatic associations with all outcomes. We conclude that, if product placement shapes attitudes towards firearms, such effects will need to be studied with stronger manipulations or more sensitive measures.

  1. Brief use of a specific gun in a violent game does not affect attitudes towards that gun

    Science.gov (United States)

    Engelhardt, Christopher R.; Bartholow, Bruce D.

    2016-01-01

    Although much attention has been paid to the question of whether violent video games increase aggressive behaviour, little attention has been paid to how such games might encourage antecedents of gun violence. In this study, we examined how product placement, the attractive in-game presentation of certain real-world firearm brands, might encourage gun ownership, a necessary antecedent of gun violence. We sought to study how the virtual portrayal of a real-world firearm (the Bushmaster AR-15) could influence players' attitudes towards the AR-15 specifically and gun ownership in general. College undergraduates (N = 176) played one of four modified video games in a 2 (gun: AR-15 or science-fiction control) × 2 (gun power: strong or weak) between-subjects design. Despite collecting many outcomes and examining many potential covariates and moderators, experimental assignment did little to influence outcomes of product evaluations or purchasing intentions with regard to the AR-15. Attitudes towards public policy and estimation of gun safety were also not influenced by experimental condition, although these might have been better tested by comparison against a no-violence control condition. By contrast, gender and political party had dramatic associations with all outcomes. We conclude that, if product placement shapes attitudes towards firearms, such effects will need to be studied with stronger manipulations or more sensitive measures. PMID:28018611

  2. Capacitively coupled pickup in MCP-based photodetectors using a conductive metallic anode

    Energy Technology Data Exchange (ETDEWEB)

    Angelico, E.; Seiss, T. [Enrico Fermi Institute, University of Chicago, 5640 S Ellis Ave, Chicago, IL 60637 (United States); Adams, B. [Incom, Inc., 294 SouthBridge Rd, Charlton, Massachusetts 01507 (United States); Elagin, A.; Frisch, H.; Spieglan, E. [Enrico Fermi Institute, University of Chicago, 5640 S Ellis Ave, Chicago, IL 60637 (United States)

    2017-02-21

    We have designed and tested a robust 20×20 cm{sup 2} thin metal film internal anode capacitively coupled to an external array of signal pads or micro-strips for use in fast microchannel plate photodetectors. The internal anode, in this case a 10 nm-thick NiCr film deposited on a 96% pure Al{sub 2}O{sub 3} 3 mm-thick ceramic plate and connected to HV ground, provides the return path for the electron cascade charge. The multi-channel pickup array consists of a printed-circuit card or glass plate with metal signal pickups on one side and the signal ground plane on the other. The pickup can be put in close proximity to the bottom outer surface of the sealed photodetector, with no electrical connections through the photodetector hermetic vacuum package other than a single ground connection to the internal anode. Two pickup patterns were tested using a small commercial MCP-PMT as the signal source: 1) parallel 50 Ω 25-cm-long micro-strips with an analog bandwidth of 1.5 GHz, and 2) a 20×20 cm{sup 2} array of 2-dimensional square ‘pads’ with sides of 1.27 cm or 2.54 cm. The rise-time of the fast input pulse is maintained for both pickup patterns. For the pad pattern, we observe 80% of the directly coupled amplitude. For the strip pattern we measure 34% of the directly coupled amplitude on the central strip of a broadened signal. The physical decoupling of the photodetector from the pickup pattern allows easy customization for different applications while maintaining high analog bandwidth.

  3. Resposta da aplicação do 1-MCP em frutos de mamoeiro 'Golden' em diferentes estádios de maturação Responses of 1-MCP applications in 'Golden' papaya fruits on differents maturation stages

    Directory of Open Access Journals (Sweden)

    Maximiliano Silva de Souza

    2009-09-01

    Full Text Available O estudo de fatores que influenciam no processo de amadurecimento é fundamental para o planejamento do processo de comercialização, principalmente em frutos com padrão de respiração climatérico e perecível, como é o caso do mamão. Nesse trabalho, avaliou-se o efeito da aplicação do 1-MCP (1-metilciclopropeno sobre o amadurecimento de frutos de mamoeiro nos estádios 0; 1 e 2 de maturação. O 1-MCP diminui a produção de etileno (≈79% e a taxa respiratória (≈45%, principalmente em frutos no estádio 0 de maturação. O uso deste inibidor da ação do etileno retardou a perda de coloração verde da casca dos frutos, principalmente em frutos nos estádios 0 e 1 de maturação. Houve redução na perda de firmeza do fruto e do mesocarpo nos estádios 1 e 2. Entretanto, em frutos no estádio 0 de maturação, a firmeza do mesocarpo manteve-se alta, o que pode comprometer a aceitação destes frutos pelo consumidor. O teor de sólidos solúveis não foi influenciado pela aplicação do 1-MCP. O efeito do 1-MCP na redução da atividade das enzimas PME e PG foi maior em frutos nos estádios 0 e 1 de maturação em comparação a frutos no estádio 2 de maturação. A atividade da PME demonstrou crescente aumento ao longo do período de armazenamento, porém a atividade da PG permaneceu baixa ao longo dos cinco primeiros dias, com aumento posterior. Os resultados mostraram que a PME exerce influência significativa na perda de firmeza da polpa nos primeiros dias, com atuação posterior da PG. O 1-MCP mostrou-se eficiente em retardar o processo de amadurecimento de frutos de mamoeiro, tornando-se mais eficiente quando associado a estádios de maturação iniciais.The study of factors that influence the process of ripening is critical for planning the marketing process, mainly in standard breathing climacteric and perishing fruits, as it is the case of papaya. In this work it was evaluated the effect of the application of 1-MCP (1

  4. The Effect of Child Access Prevention Laws on Non-Fatal Gun Injuries

    OpenAIRE

    Jeff DeSimone; Sara Markowitz

    2005-01-01

    Many states have passed child access prevention (CAP) laws, which hold the gun owner responsible if a child gains access to a gun that is not securely stored. Previous CAP law research has focused exclusively on gun-related deaths even though most gun injuries are not fatal. We use annual hospital discharge data from 1988-2001 to investigate whether CAP laws decrease non-fatal gun injuries. Results from Poisson regressions that control for various hospital, county and state characteristics, i...

  5. Whiplash and the compensation hypothesis.

    Science.gov (United States)

    Spearing, Natalie M; Connelly, Luke B

    2011-12-01

    Review article. To explain why the evidence that compensation-related factors lead to worse health outcomes is not compelling, either in general, or in the specific case of whiplash. There is a common view that compensation-related factors lead to worse health outcomes ("the compensation hypothesis"), despite the presence of important, and unresolved sources of bias. The empirical evidence on this question has ramifications for the design of compensation schemes. Using studies on whiplash, this article outlines the methodological problems that impede attempts to confirm or refute the compensation hypothesis. Compensation studies are prone to measurement bias, reverse causation bias, and selection bias. Errors in measurement are largely due to the latent nature of whiplash injuries and health itself, a lack of clarity over the unit of measurement (specific factors, or "compensation"), and a lack of appreciation for the heterogeneous qualities of compensation-related factors and schemes. There has been a failure to acknowledge and empirically address reverse causation bias, or the likelihood that poor health influences the decision to pursue compensation: it is unclear if compensation is a cause or a consequence of poor health, or both. Finally, unresolved selection bias (and hence, confounding) is evident in longitudinal studies and natural experiments. In both cases, between-group differences have not been addressed convincingly. The nature of the relationship between compensation-related factors and health is unclear. Current approaches to testing the compensation hypothesis are prone to several important sources of bias, which compromise the validity of their results. Methods that explicitly test the hypothesis and establish whether or not a causal relationship exists between compensation factors and prolonged whiplash symptoms are needed in future studies.

  6. A numerical study of emittance growths in RF guns

    CERN Document Server

    Masuda, K; Sobajima, M; Kitagaki, J; Ohnishi, M; Toku, H; Yoshikawa, K

    1999-01-01

    A beam with greatly reduced emittance is required for further improvements of FELs, in particular, for FELs of shorter wavelengths, and of narrower bandwidths. From this viewpoint, the BNL/SLAC/UCLA 1.6-cell S-band photocathode RF gun performance characteristics were calculated, first in order to evaluate what may contribute to the emittance growths in photocathode RF guns. We developed an RF gun to produce an electron beam with an extremely low emittance, by using a 2-D simulation code. It is found that, by optimizing the laser injection phase, the drive laser spot radius and the cavity shape around the laser spot, the beam emittance by the 1.6-cell RF gun can be greatly reduced to 2.1 pi mm mrad, from the previous 4.4 pi mm mrad of the original shape.

  7. A NEW THERMIONIC RF ELECTRON GUN FOR SYNCHROTRON LIGHT SOURCES

    Energy Technology Data Exchange (ETDEWEB)

    Kutsaev, Sergey; Agustsson, R.; Hartzell, J; Murokh, A.; Nassiri, A.; Savin, E.; Smirnov, A.V.; Smirnov, A. Yu; Sun, Y.; Verma, A; Waldschmidt, Geoff; Zholents, A.

    2017-06-02

    A thermionic RF gun is a compact and efficient source of electrons used in many practical applications. RadiaBeam Systems and the Advanced Photon Source at Argonne National Laboratory collaborate in developing of a reliable and robust thermionic RF gun for synchrotron light sources which would offer substantial improvements over existing thermionic RF guns and allow stable operation with up to 1A of beam peak current at a 100 Hz pulse repetition rate and a 1.5 μs RF pulse length. In this paper, we discuss the electromagnetic and engineering design of the cavity and report the progress towards high power tests of the cathode assembly of the new gun.

  8. Progress on Using NEA Cathodes in an RF Gun

    CERN Document Server

    Fliller, Raymond P; Blüm, Hans; Edwards, Helen; Hüning, Markus; Schultheiss, Tom; Sinclair, Charles K

    2005-01-01

    RF guns have proven useful in multiple accelerator applications, and are an attractive electron source for the ILC. Using a NEA GaAs photocathode in such a gun allows for the production of polarized electron beams. However the lifetime of a NEA cathode in this environment is reduced by ion and electron bombardment and residual gas oxidation. We report progress made with studies to produce a RF gun using a NEA GaAs photocathode to produce polarized electron beams. Attempts to reduce the residual gas pressure in the gun are discussed. Initial measurements of ion flux through the cathode port are compared with simulations of ion bombardment. Future directions are also discussed.

  9. Modeling of the 35-mm Rarefaction Wave Gun

    National Research Council Canada - National Science Library

    Coffee, Terence P

    2006-01-01

    .... The opening of the breech creates a rarefaction wave that travels down the bore of the gun. If the timing is done correctly, the rarefaction wave will not reach the projectile until at or after muzzle exit...

  10. Hartford's gun buy-back program: are we on target?

    Science.gov (United States)

    Marinelli, Laura W; Thaker, Shefali; Borrup, Kevin; Shapiro, David S; Bentley, George C; Saleheen, Hassan; Lapidus, Garry; Campbell, Brendan T

    2013-09-01

    Gunbuy-backprograms have been proposed as away to remove unwanted firearms from circulation, but remain controversial because their ability to prevent firearm injuries remains unproven. The purpose of this study is to describe the demographics of individuals participating in Connecticut's gun buy-backprogram in the context of annual gun sales and the epidemiology of firearm violence in the state. Over four years the buy-back program collected 464 firearms, including 232 handguns. In contrast, 91,602 firearms were sold in Connecticut during 2009 alone. The incidence of gun-related deaths was unchanged in the two years following the inception of the buy-back program. Suicide was associated with older age (mean = 51 +/- 18years) and Caucasian race (n = 539, 90%). Homicide was associated with younger age (mean = 30 +/- 12 years) and minority race (n = 425, 81%). A gun buy-back program alone is not likely to produce a measurable decrease in firearm injuries and deaths.

  11. Atmospheric pressure DBD gun and its application in ink printability

    International Nuclear Information System (INIS)

    Chen Qiang; Zhang Yuefei; Han Erli; Ge Yuanjing

    2005-01-01

    In this paper, a plasma source discharging at atmospheric pressure and its characterization diagnosed by a Langmuir probe and a digital camera are presented. As an application the dielectric barrier discharge (DBD) gun modifying an ultraviolet cured resin surface for ink printability is reported. The results from the digital camera indicate the uniformity and homogeneity of the plasma generated from the gun in the downstream but depending on the input power, diameter of electrodes, gas flow rates and the distance between the substrates and the nozzle. The contact angle measurement proves the efficiency of gun during the surface modification. The ink printability following DBD gun processing described here was significantly improved. The performed surface analysis using Fourier transform infrared indicates that the polarity of surface grafted in plasma is responsible for the film printability

  12. Finite element analyses for RF photoinjector gun cavities

    International Nuclear Information System (INIS)

    Marhauser, F.

    2006-01-01

    This paper details electromagnetical, thermal and structural 3D Finite Element Analyses (FEA) for normal conducting RF photoinjector gun cavities. The simulation methods are described extensively. Achieved results are presented. (orig.)

  13. Electrostatic focusing of directly heated linear filament gun using EGUN

    International Nuclear Information System (INIS)

    Iqbal, Munawar; Lodhi, M.A.K.; Majeed, Zahid; Batani, Dimitri

    2011-01-01

    This paper presents the optimization of a line source rectangular electron gun using electrostatic focusing. We optimized the gun by shaping the configuration of its electrodes in order to achieve the desired focusing characteristics, namely maximum focusing distance and minimum beam spread. The optimization has been carried out using the software EGUN. We have also simplified the gun design using only one focusing electrode at the same potential as that of the cathode and by avoiding magnetic focusing field, separate focusing electrodes and additional power supply, thus minimizing the cost without any loss in its accuracy and efficient performance. This gun with the optimum configuration was used in actual experiment and the results of the simulation were compared with the experimental measurements.

  14. Finite element analyses of a linear-accelerator electron gun

    Science.gov (United States)

    Iqbal, M.; Wasy, A.; Islam, G. U.; Zhou, Z.

    2014-02-01

    Thermo-structural analyses of the Beijing Electron-Positron Collider (BEPCII) linear-accelerator, electron gun, were performed for the gun operating with the cathode at 1000 °C. The gun was modeled in computer aided three-dimensional interactive application for finite element analyses through ANSYS workbench. This was followed by simulations using the SLAC electron beam trajectory program EGUN for beam optics analyses. The simulations were compared with experimental results of the assembly to verify its beam parameters under the same boundary conditions. Simulation and test results were found to be in good agreement and hence confirmed the design parameters under the defined operating temperature. The gun is operating continuously since commissioning without any thermal induced failures for the BEPCII linear accelerator.

  15. Electrostatic focusing of directly heated linear filament gun using EGUN

    Energy Technology Data Exchange (ETDEWEB)

    Iqbal, Munawar, E-mail: muniqbal@yahoo.com [Department of Physics, Texas Tech University, Lubbock, TX 79409 (United States); Lodhi, M.A.K. [Department of Physics, Texas Tech University, Lubbock, TX 79409 (United States); Majeed, Zahid [National Engineering and Science Commission, Islamabad (Pakistan); Batani, Dimitri [Dipartimento di Fisica, Universita degli Studi di Milano Bicocca (Italy)

    2011-06-11

    This paper presents the optimization of a line source rectangular electron gun using electrostatic focusing. We optimized the gun by shaping the configuration of its electrodes in order to achieve the desired focusing characteristics, namely maximum focusing distance and minimum beam spread. The optimization has been carried out using the software EGUN. We have also simplified the gun design using only one focusing electrode at the same potential as that of the cathode and by avoiding magnetic focusing field, separate focusing electrodes and additional power supply, thus minimizing the cost without any loss in its accuracy and efficient performance. This gun with the optimum configuration was used in actual experiment and the results of the simulation were compared with the experimental measurements.

  16. Electrostatic focusing of directly heated linear filament gun using EGUN

    Science.gov (United States)

    Iqbal, Munawar; Lodhi, M. A. K.; Majeed, Zahid; Batani, Dimitri

    2011-06-01

    This paper presents the optimization of a line source rectangular electron gun using electrostatic focusing. We optimized the gun by shaping the configuration of its electrodes in order to achieve the desired focusing characteristics, namely maximum focusing distance and minimum beam spread. The optimization has been carried out using the software EGUN. We have also simplified the gun design using only one focusing electrode at the same potential as that of the cathode and by avoiding magnetic focusing field, separate focusing electrodes and additional power supply, thus minimizing the cost without any loss in its accuracy and efficient performance. This gun with the optimum configuration was used in actual experiment and the results of the simulation were compared with the experimental measurements.

  17. High voltage processing of the SLC polarized electron gun

    International Nuclear Information System (INIS)

    Saez, P.; Clendenin, J.; Garden, C.; Hoyt, E.; Klaisner, L.; Prescott, C.; Schultz, D.; Tang, H.

    1993-04-01

    The SLC polarized electron gun operates at 120 kV with very low dark current to maintain the ultra high vacuum (UHV). This strict requirement protects the extremely sensitive photocathode from contaminants caused by high voltage (HV) activity. Thorough HV processing is thus required x-ray sensitive photographic film, a nanoammeter in series with gun power supply, a radiation meter, a sensitive residual gas analyzer and surface x-ray spectrometry were used to study areas in the gun where HV activity occurred. By reducing the electric field gradients, carefully preparing the HV surfaces and adhering to very strict clean assembly procedures, we found it possible to process the gun so as to reduce both the dark current at operating voltage and the probability of HV discharge. These HV preparation and processing techniques are described

  18. Finite element analyses of a linear-accelerator electron gun

    Energy Technology Data Exchange (ETDEWEB)

    Iqbal, M., E-mail: muniqbal.chep@pu.edu.pk, E-mail: muniqbal@ihep.ac.cn [Centre for High Energy Physics, University of the Punjab, Lahore 45590 (Pakistan); Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); Wasy, A. [Department of Mechanical Engineering, Changwon National University, Changwon 641773 (Korea, Republic of); Islam, G. U. [Centre for High Energy Physics, University of the Punjab, Lahore 45590 (Pakistan); Zhou, Z. [Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China)

    2014-02-15

    Thermo-structural analyses of the Beijing Electron-Positron Collider (BEPCII) linear-accelerator, electron gun, were performed for the gun operating with the cathode at 1000 °C. The gun was modeled in computer aided three-dimensional interactive application for finite element analyses through ANSYS workbench. This was followed by simulations using the SLAC electron beam trajectory program EGUN for beam optics analyses. The simulations were compared with experimental results of the assembly to verify its beam parameters under the same boundary conditions. Simulation and test results were found to be in good agreement and hence confirmed the design parameters under the defined operating temperature. The gun is operating continuously since commissioning without any thermal induced failures for the BEPCII linear accelerator.

  19. Finite element analyses of a linear-accelerator electron gun

    International Nuclear Information System (INIS)

    Iqbal, M.; Wasy, A.; Islam, G. U.; Zhou, Z.

    2014-01-01

    Thermo-structural analyses of the Beijing Electron-Positron Collider (BEPCII) linear-accelerator, electron gun, were performed for the gun operating with the cathode at 1000 °C. The gun was modeled in computer aided three-dimensional interactive application for finite element analyses through ANSYS workbench. This was followed by simulations using the SLAC electron beam trajectory program EGUN for beam optics analyses. The simulations were compared with experimental results of the assembly to verify its beam parameters under the same boundary conditions. Simulation and test results were found to be in good agreement and hence confirmed the design parameters under the defined operating temperature. The gun is operating continuously since commissioning without any thermal induced failures for the BEPCII linear accelerator

  20. Performance of the Antares large area cold cathode electron gun

    International Nuclear Information System (INIS)

    Rosocha, L.A.; Mansfield, C.R.

    1983-01-01

    The performance of the electron gun which supplies ionization for the Antares high-power electron-beam-sustained CO 2 -laser power amplifier is described. This electron gun is a coaxial cylindrical cold cathode vacuum triode having a total electron aperture area of approximately 9 m 2 . Electrons are extracted from the gun in pulses of 3 to 6 μs duration, average current densities of 40 to 60 mA/cm 2 , and electron energies of 450 to 500 keV. The main areas of discussion in this paper are the performance in terms of grid control, current-density balance, and current runaway due to breakdown limitations. Comparison of the experimental results with the predictions of a theoretical model for the electron gun are also presented